LOCUS 007_Delta6_2_Actual_Genomes_Bacillus_subtilis_trycycler_hybrid_assembly 3876926 bp DNA circular UNA 22-MAR-2021 DEFINITION Bacillus subtilis strain Delta6 (hybrid trycycler assembly). ACCESSION urn.local...1cx-cvskbt0 VERSION urn.local...1cx-cvskbt0 KEYWORDS . SOURCE ORGANISM . FEATURES Location/Qualifiers S_feature complement(3876816..658) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" CDS 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" /label="dnaA CDS" gene 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /label="dnaA gene" promotor_-10 complement(631..649) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(665..670) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1342..1529 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" /label="dnaN CDS" gene 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /label="dnaN gene" downshifts 2650 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" promotor_-35 2731..2735 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752..2771 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" /label="rlbA CDS" gene 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /label="rlbA gene" CDS 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" /label="recF CDS" gene 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /label="recF gene" misc_feature 3226..3245 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3244 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" /label="remB CDS" gene 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /label="remB gene" CDS 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" /label="gyrB CDS" gene 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /label="gyrB gene" promotor_-10 complement(6003..6021) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6005) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(6037..6042) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6375..6584 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" /label="gyrA CDS" gene 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /label="gyrA gene" promotor_-35 8964..8967 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 8965 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 8984..9001 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9031 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 9095..9101 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9115..9134 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9120..9205 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9120 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 9191..9198 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9207 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 9213..9232 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-16S rRNA" gene 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /label="rrnO-16S gene" tRNA 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ile tRNA" gene 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /label="trnO-Ile gene" tRNA 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ala tRNA" gene 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /label="trnO-Ala gene" rRNA 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-23S rRNA" gene 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /label="rrnO-23S gene" rRNA 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-5S rRNA" gene 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /label="rrnO-5S gene" S_feature 14402..15459 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" /label="yaaC CDS" gene complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /label="yaaC gene" promotor_-35 15438..15445 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15460..15479 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15461 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(15466) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(15475..15486) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15500..15506) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" /label="guaB CDS" gene 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /label="guaB gene" downshifts complement(15510) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(15536..15636) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15576) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(16829..17424) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 16960 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 17018..17022 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17038..17057 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17044..17124 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17044 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" /label="dacA CDS" gene 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /label="dacA gene" promotor_-10 complement(17413..17431) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17424) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(17446..17452) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18338 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" /label="downshifts" S_feature 18457..18565 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18535..18538 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18553..18572 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18567..18652 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18567 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" /label="pdxS CDS" gene 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /label="pdxS gene" S_feature complement(18785..19514) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19502..19520) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19514) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(19536..19541) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" /label="pdxT CDS" gene 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /label="pdxT gene" misc_RNA 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboS RNA" gene 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /label="tboS gene" downshifts 20379 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" /label="downshifts" CDS 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" /label="serS CDS" gene 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /label="serS gene" downshifts 21726 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 21837..21844 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 21859..21878 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 21859 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="upshifts" tRNA 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Ser1 tRNA" gene 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /label="trnSL-Ser1 gene" downshifts 21998 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" /label="downshifts" S_feature 22043..22120 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " /label="dck CDS" gene complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /label="dck gene" promotor_-35 22106..22112 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22111) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 22122..22758 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22122 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 22126..22137 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" /label="dgk CDS" gene complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /label="dgk gene" promotor_-10 complement(23401..23420) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23419) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(23436..23440) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" /label="sleL CDS" gene complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /label="sleL gene" downshifts complement(23496) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(24773..24791) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(24794) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(24807..24812) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" /label="yaaI CDS" gene complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /label="yaaI gene" promotor_-35 25223..25227 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25242..25261 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25246..25442 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25248 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" promotor_-10 complement(25382..25400) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25401) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(25415..25421) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" /label="tadA CDS" gene 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /label="tadA gene" promotor_-35 25932..25938 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25952..25971 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" /label="scr RNA" gene 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /label="scr gene" S_feature 25974..26123 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 25974 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" S_feature 26227..26322 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26279 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 26343..26346 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26370 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" /label="dnaX CDS" gene 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /label="dnaX gene" promotor_-35 27937..27944 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 27959..27978 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 27974 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" /label="ebfC CDS" gene 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /label="ebfC gene" CDS 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" /label="recR CDS" gene 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /label="recR gene" CDS 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" /label="yaaL CDS" gene 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /label="yaaL gene" promotor_-35 29299..29304 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29316 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="upshifts" promotor_-10 29320..29338 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" /label="bofA CDS" gene 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /label="bofA gene" promotor_-35 29639..29646 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 29660..29679 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 29667..29869 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 29667 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-16S" gene 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /label="rrnA-16S gene" tRNA 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ile" gene 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /label="trnA-Ile gene" tRNA 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ala" gene 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /label="trnA-Ala gene" rRNA 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-23S" gene 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /label="rrnA-23S gene" S_feature 34695..34827 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-5S" gene 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /label="rrnA-5S gene" S_feature 34947..35049 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35010..35018 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35032..35051 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35051 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="upshifts" CDS 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" /label="csfB CDS" gene 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /label="csfB gene" downshifts 35300 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" /label="downshifts" promotor_-35 35361..35370 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35382..35397 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35388 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" /label="xpaC CDS" gene 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /label="xpaC gene" CDS 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" /label="yaaN CDS" gene 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /label="yaaN gene" S_feature 37230..37310 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" /label="yaaO CDS" gene 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /label="yaaO gene" promotor_-35 38673..38679 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 38694..38712 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 38703 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="upshifts" CDS 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" /label="tmk CDS" gene 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /label="tmk gene" promotor_-35 39383..39390 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39403..39422 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39414 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" /label="darA CDS" gene 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /label="darA gene" CDS 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" /label="yaaR CDS" gene 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /label="yaaR gene" CDS 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" /label="holB CDS" gene 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /label="holB gene" CDS 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " /label="ricT CDS" gene 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /label="ricT gene" CDS 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" /label="dnaH CDS" gene 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /label="dnaH gene" CDS 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" /label="trmNF CDS" gene 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /label="trmNF gene" CDS 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" /label="yazA CDS" gene 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /label="yazA gene" CDS 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" /label="rsmI CDS" gene 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /label="rsmI gene" downshifts 44363 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" /label="abrB CDS" gene complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /label="abrB gene" downshifts complement(44441) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 44760 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(44796..44815) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(44813) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(44815..44990) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(44829..44836) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(44986..45005) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(44990) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="upshifts" promotor_-35 complement(45019..45026) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45090..45094 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45109..45128 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45115..45223 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45115 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="upshifts" CDS 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" /label="metS CDS" gene 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /label="metS gene" promotor_-10 complement(45972..45991) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45980) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(46007..46011) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47202 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" S_feature complement(47264..49610) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" /label="dayD CDS" gene 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /label="dayD gene" S_feature 48065..48145 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48122..48127 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48143..48161 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48147 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 48172..48175 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48190..48209 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48207 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="upshifts" CDS 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" /label="yabE CDS" gene 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /label="yabE gene" promotor_-35 48240..48247 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48258 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 48262..48281 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49494 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-35 49556..49560 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49576..49595 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49578..49677 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49578 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(49602..49617) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(49618) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(49629..49638) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 49674..49690 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" /label="rnmV CDS" gene 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /label="rnmV gene" upshifts 49688 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" CDS 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" /label="rsmA CDS" gene 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /label="rsmA gene" downshifts 51074 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 51124..51133 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51147..51166 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51149..51270 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51149 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="upshifts" CDS 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" /label="prtG CDS" gene 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /label="prtG gene" downshifts 52130 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 52240..52310 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52301..52308 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52312 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 52322..52341 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52331..52345) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52338) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(52354..52358) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" /label="veg CDS" gene 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /label="veg gene" downshifts 52526 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" /label="downshifts" downshifts 52613 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" /label="downshifts" promotor_-35 52679..52685 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 52699..52710 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 52702..52773 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 52702 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="upshifts" CDS 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" /label="sspF CDS" gene 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /label="sspF gene" downshifts 52944 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(52954..55308) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53037..53041 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53057..53076 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53060 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="upshifts" CDS 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" /label="ispE CDS" gene 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /label="ispE gene" CDS 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" /label="purR CDS" gene 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /label="purR gene" CDS 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" /label="ridA CDS" gene 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /label="ridA gene" downshifts 55253 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(55297..55315) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55298..55406 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55309) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(55331..55336) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55386..55394 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55405..55423 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55408 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="upshifts" CDS 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" /label="spoVG CDS" gene 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /label="spoVG gene" downshifts 55739 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" /label="downshifts" S_feature 55784..55895 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 55877..55881 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 55897..55916 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 55897 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" /label="glmU CDS" gene 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /label="glmU gene" downshifts complement(57288) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" CDS 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" /label="prs CDS" gene 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /label="prs gene" promotor_-35 58302..58308 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58321 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 58323..58341 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" /label="ctc CDS" gene 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /label="ctc gene" downshifts 58972 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" /label="pth CDS" gene 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /label="pth gene" misc_feature 59274..59277 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59280 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" /label="fin CDS" gene 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /label="fin gene" S_feature 59952..60020 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" /label="mfd CDS" gene 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /label="mfd gene" promotor_-35 63572..63578 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 63592..63689 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 63592..63603 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 63592 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" /label="spoVT CDS" gene 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /label="spoVT gene" downshifts 64230 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 64326..64345 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64337 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" /label="yabM CDS" gene 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /label="yabM gene" promotor_-35 65877..65884 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 65899..65918 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 65913 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="upshifts" CDS 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" /label="yabN CDS" gene 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /label="yabN gene" promotor_-35 66637..66644 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 66658..66676 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 66672 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="upshifts" promotor_no_box complement(67060..67160) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67100) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" /label="hslR CDS" gene 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /label="hslR gene" promotor_-35 67733..67738 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 67754..67772 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 67772 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(67804) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" /label="downshifts" CDS 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" /label="spcP CDS" gene 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /label="spcP gene" CDS 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" /label="spcQ CDS" gene 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /label="spcQ gene" promotor_-35 68611..68620 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68633..68648 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68635 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 68667..68675 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68686..68704 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68696 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" /label="divIC CDS" gene 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /label="divIC gene" CDS 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" /label="yabR CDS" gene 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /label="yabR gene" downshifts 69597 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 69711..69718 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69732..69751 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69747 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="upshifts" tRNA 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Met1 tRNA" gene 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /label="trnSL-Met1 gene" tRNA 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu1 tRNA" gene 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /label="trnSL-Glu1 gene" downshifts 69928 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 69973..70084 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70080..70099 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70086 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="upshifts" CDS 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" /label="spoIIE CDS" gene 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /label="spoIIE gene" downshifts 70170 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" /label="downshifts" S_feature complement(70781..71390) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(70807) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(71363..71381) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71389) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(71397..71402) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 71594..71600 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 71615..71633 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 71622 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 72632..72635 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72653..72670 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72656 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="upshifts" CDS 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" /label="yabS CDS" gene 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /label="yabS gene" CDS 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" /label="prkT CDS" gene 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /label="prkT gene" promotor_-35 73948..73954 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 73970..73988 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 73976 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="upshifts" promotor_-35 74446..74453 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74467..74486 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74477 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" /label="tilS CDS" gene 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /label="tilS gene" promotor_-35 75315..75322 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75337..75356 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75340 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" downshifts complement(75933) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" /label="hprT CDS" gene 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /label="hprT gene" upshifts complement(76340) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(76342..76346) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76364..76367) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76478..76574 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" /label="ftsH CDS" gene 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /label="ftsH gene" downshifts 78486 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(78525..78529) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78531..78616 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78533) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 78593..78600 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 78614..78633 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 78618..78682 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 78618 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" /label="coaX CDS" gene 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /label="coaX gene" CDS 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" /label="hslO CDS" gene 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /label="hslO gene" CDS 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" /label="yacD CDS" gene 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /label="yacD gene" promotor_-35 81016..81021 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81038..81056 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81039 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 81285..81292 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81307..81326 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81314 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" /label="cysK CDS" gene 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /label="cysK gene" downshifts 82281 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" /label="downshifts" promotor_-35 82335..82343 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82357..82365 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82359 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 82387..82390 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82405..82424 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82415 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" /label="pabB CDS" gene 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /label="pabB gene" promotor_-35 83257..83259 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83277..83295 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83283 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 83624..83631 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 83644..83663 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 83657 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" /label="pabA CDS" gene 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /label="pabA gene" CDS 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" /label="pabC CDS" gene 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /label="pabC gene" CDS 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" /label="folP CDS" gene 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /label="folP gene" CDS 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" /label="folB CDS" gene 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /label="folB gene" CDS 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" /label="folK CDS" gene 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /label="folK gene" CDS 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" /label="yazB CDS" gene 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /label="yazB gene" CDS 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " /label="dusB CDS" gene 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /label="dusB gene" S_feature complement(87641..89157) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88227..88317 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" /label="lysS CDS" gene 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /label="lysS gene" promotor_-10 complement(89141..89159) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89157) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(89175..89180) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 89798 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 89893..89900 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 89909..90126 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 89909 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 89914..89933 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(89959) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" rRNA 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-16S rRNA" gene 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /label="rrnJ-16S gene" rRNA 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-23S rRNA" gene 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /label="rrnJ-23S gene" rRNA 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-5S rRNA" gene 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /label="rrnJ-5S gene" tRNA 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Val tRNA" gene 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /label="trnJ-Val gene" tRNA 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Thr tRNA" gene 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /label="trnJ-Thr gene" tRNA 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Lys tRNA" gene 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /label="trnJ-Lys gene" tRNA 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu1 tRNA" gene 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /label="trnJ-Leu1 gene" tRNA 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Gly tRNA" gene 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /label="trnJ-Gly gene" tRNA 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu2 tRNA" gene 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /label="trnJ-Leu2 gene" tRNA 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Arg tRNA" gene 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /label="trnJ-Arg gene" tRNA 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Pro tRNA" gene 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /label="trnJ-Pro gene" tRNA 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Ala tRNA" gene 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /label="trnJ-Ala gene" rRNA 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-16S rRNA" gene 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /label="rrnW-16S gene" rRNA 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-23S rRNA" gene 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /label="rrnW-23S gene" rRNA 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-5S rRNA" gene 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /label="rrnW-5S gene" S_feature 100803..100880 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 100850..100853 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100869..100888 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100882 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-35 100916..100922 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 100936..100955 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 100947 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="upshifts" promotor_-35 100962..100969 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100983..101002 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100995 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" /label="ctsR CDS" gene 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /label="ctsR gene" misc_feature complement(101151..101155) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101157) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" /label="mcsA CDS" gene 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /label="mcsA gene" CDS 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" /label="mcsB CDS" gene 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /label="mcsB gene" CDS 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" /label="clpC CDS" gene 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /label="clpC gene" downshifts 105590 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" /label="radA CDS" gene 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /label="radA gene" promotor_-35 106142..106151 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106164..106179 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106167 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" /label="disA CDS" gene 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /label="disA gene" S_feature 108150..108264 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" /label="yacL CDS" gene 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /label="yacL gene" downshifts complement(109187) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" /label="downshifts" CDS 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" /label="ispD CDS" gene 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /label="ispD gene" CDS 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" /label="ispF CDS" gene 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /label="ispF gene" promotor_-35 110551..110558 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110572..110591 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110585 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" /label="gltX CDS" gene 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /label="gltX gene" promotor_-35 111567..111576 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111590..111609 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111590 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="upshifts" S_feature 112090..112390 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " /label="cysE CDS" gene 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /label="cysE gene" CDS 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" /label="cysS CDS" gene 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /label="cysS gene" CDS 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" /label="mrnC CDS" gene 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /label="mrnC gene" CDS 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" /label="rlmB CDS" gene 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /label="rlmB gene" CDS 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" /label="raeA CDS" gene 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /label="raeA gene" promotor_-35 116127..116134 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116149..116168 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116151 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" /label="sigH CDS" gene 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /label="sigH gene" downshifts complement(116645) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" /label="downshifts" S_feature 116848..116939 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" /label="rpmGB CDS" gene 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /label="rpmGB gene" CDS 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" /label="secE CDS" gene 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /label="secE gene" S_feature 117303..117480 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117474) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" /label="nusG CDS" gene 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /label="nusG gene" upshifts complement(117569) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(117572..117576) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(117591..117596) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118025..118032 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118043..118181 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118043 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 118046..118065 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" /label="rplK CDS" gene 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /label="rplK gene" S_feature 118608..118701 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" /label="rplA CDS" gene 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /label="rplA gene" downshifts complement(119374) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" /label="ldlJ RNA" gene 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /label="ldlJ gene" upshifts complement(119462) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(119465..119469) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119518 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" /label="downshifts" CDS 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" /label="rplJ CDS" gene 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /label="rplJ gene" CDS 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" /label="rplL CDS" gene 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /label="rplL gene" downshifts 120485 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" /label="downshifts" downshifts 120558 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" /label="downshifts" CDS 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" /label="rlmG CDS" gene 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /label="rlmG gene" promotor_-35 121259..121263 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121277..121509 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121277 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 121279..121298 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" /label="rpoB CDS" gene 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /label="rpoB gene" promotor_-10 complement(123095..123114) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123098) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123128..123137) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(123966..123970) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123971) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123985..123991) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" /label="rpoC CDS" gene 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /label="rpoC gene" downshifts complement(128217) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" upshifts complement(128371) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(128389..128390) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(128701) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 128753..128874 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 128856..128863 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 128876 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 128877..128896 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(128894..128898) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(128897) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" /label="rulS CDS" gene 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /label="rulS gene" S_feature 129180..129292 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" /label="rpsL CDS" gene 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /label="rpsL gene" CDS 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" /label="rpsG CDS" gene 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /label="rpsG gene" CDS 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" /label="fusA CDS" gene 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /label="fusA gene" S_feature 132354..132472 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" /label="tufA CDS" gene 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /label="tufA gene" downshifts 133658 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" /label="downshifts" misc_feature complement(133689..133692) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(133693) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 133719..133738 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 133727 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" /label="ybaC CDS" gene 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /label="ybaC gene" promotor_-35 134725..134732 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 134746..134765 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 134761..134954 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 134761 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" /label="rpsJ CDS" gene 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /label="rpsJ gene" CDS 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" /label="rplC CDS" gene 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /label="rplC gene" CDS 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" /label="rplD CDS" gene 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /label="rplD gene" CDS 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" /label="rplW CDS" gene 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /label="rplW gene" CDS 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" /label="rplB CDS" gene 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /label="rplB gene" downshifts complement(137038) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" CDS 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" /label="rpsS CDS" gene 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /label="rpsS gene" CDS 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" /label="rplV CDS" gene 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /label="rplV gene" CDS 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" /label="rpsC CDS" gene 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /label="rpsC gene" downshifts complement(138446) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(138527..138531) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138534) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(138548..138550) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" /label="rplP CDS" gene 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /label="rplP gene" CDS 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" /label="rpmC CDS" gene 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /label="rpmC gene" CDS 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" /label="rpsQ CDS" gene 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /label="rpsQ gene" CDS 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" /label="rplNA CDS" gene 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /label="rplNA gene" CDS 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" /label="rplX CDS" gene 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /label="rplX gene" CDS 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" /label="rplE CDS" gene 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /label="rplE gene" CDS 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" /label="rpsNA CDS" gene 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /label="rpsNA gene" CDS 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" /label="rpsH CDS" gene 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /label="rpsH gene" downshifts complement(141966) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" /label="downshifts" CDS 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" /label="rplF CDS" gene 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /label="rplF gene" CDS 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" /label="rplR CDS" gene 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /label="rplR gene" CDS 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" /label="rpsE CDS" gene 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /label="rpsE gene" CDS 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" /label="rpmD CDS" gene 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /label="rpmD gene" CDS 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" /label="rplO CDS" gene 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /label="rplO gene" CDS 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" /label="secY CDS" gene 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /label="secY gene" CDS 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " /label="adk CDS" gene 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /label="adk gene" CDS 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" /label="mapA CDS" gene 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /label="mapA gene" CDS 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" /label="ybzG CDS" gene 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /label="ybzG gene" CDS 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" /label="infA CDS" gene 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /label="infA gene" CDS 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" /label="rpmJ CDS" gene 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /label="rpmJ gene" CDS 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" /label="rpsM CDS" gene 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /label="rpsM gene" CDS 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" /label="rpsK CDS" gene 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /label="rpsK gene" S_feature 148346..148521 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" /label="rpoA CDS" gene 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /label="rpoA gene" CDS 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" /label="rplQ CDS" gene 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /label="rplQ gene" downshifts 149908 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" /label="downshifts" S_feature 149953..150033 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" /label="ecfA CDS" gene 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /label="ecfA gene" CDS 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" /label="ecfAB CDS" gene 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /label="ecfAB gene" CDS 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" /label="ecfT CDS" gene 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /label="ecfT gene" CDS 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" /label="truA CDS" gene 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /label="truA gene" S_feature complement(152630..153098) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 152763..152768 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 152783..152800 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 152802 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(153098..153117) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153120) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(153130..153139) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153291..153297 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153312..153331 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153316 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" /label="ldlM RNA" gene 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /label="ldlM gene" CDS 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" /label="rplM CDS" gene 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /label="rplM gene" CDS 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" /label="rpsI CDS" gene 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /label="rpsI gene" downshifts 154258 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" /label="downshifts" promotor_-35 154400..154407 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154421..154440 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154429..154710 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154429 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature 154709..154728 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 154712 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" /label="ybaJ CDS" gene 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /label="ybaJ gene" downshifts 155505 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 155644..155650 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 155665..155676 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 155672 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" /label="ybaK CDS" gene 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /label="ybaK gene" promotor_-35 156143..156148 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156164..156182 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156165 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" /label="cwlD CDS" gene 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /label="cwlD gene" upshifts 156961 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="upshifts" misc_feature 156964..156983 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" /label="salA CDS" gene 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /label="salA gene" S_feature complement(157641..158105) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158056 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" /label="downshifts" S_feature 158101..158772 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" /label="gerD CDS" gene complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /label="gerD gene" promotor_-10 complement(158695..158706) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(158707) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(158720..158726) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(158740..159369) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" /label="kbaA CDS" gene 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /label="kbaA gene" S_feature 159370..160264 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" /label="pdaB CDS" gene complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /label="pdaB gene" promotor_-10 complement(160165..160183) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160185) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(160199..160204) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160242..160249 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160264..160283 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160266..160483 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160266 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-16S rRNA" gene 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /modified_by="User" /label="rrnI-16S gene" Polymorphism join(160830,160832) /Source="geneious" /ID="SNP_BsDelta6_161240_161239" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=45 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value="4.2e-57" /Variant_Raw_Frequency=41 /comment="rrnI-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-23S rRNA" gene 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /label="rrnI-23S gene" rRNA 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-5S rRNA" gene 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /label="rrnI-5S gene" Polymorphism join(165341,165342) /Source="geneious" /ID="SNP_BsDelta6_165748_165749" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="-TC" /Codon_Change /Coverage="172 -> 174" /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TC" /Variant_Nucleotides /Variant_P_Value="1.5e-307" /Variant_Raw_Frequency=152 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(165342,165344) /Source="geneious" /ID="SNP_BsDelta6_165751_165751" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="C -> T" /Codon_Change /Coverage=172 /locus_tag /Protein_Effect /Reference_Frequency="1.2%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=168 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Asn tRNA" gene 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /label="trnI-Asn gene" Polymorphism join(165417,165419) /Source="geneious" /ID="SNP_BsDelta6_165826_165825" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=163 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=160 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Thr tRNA" gene 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /label="trnI-Thr gene" tRNA 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Gly tRNA" gene 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /label="trnI-Gly gene" Polymorphism join(165630,165632) /Source="geneious" /ID="SNP_BsDelta6_166038_166037" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="T" /Codon_Change /Coverage=154 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=148 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Arg tRNA" gene 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /label="trnI-Arg gene" tRNA 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Pro tRNA" gene 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /label="trnI-Pro gene" tRNA 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Ala tRNA" gene 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /label="trnI-Ala gene" Polymorphism join(165937,165938) /Source="geneious" /ID="SNP_BsDelta6_166344_166344" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-G" /Codon_Change /Coverage=132 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides /Variant_P_Value="4.9e-75" /Variant_Raw_Frequency=130 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-16S rRNA" gene 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /label="rrnH-16S gene" rRNA 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-23S rRNA" gene 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /label="rrnH-23S gene" rRNA 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-5S rRNA" gene 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /label="rrnH-5S gene" rRNA 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-16S rRNA" gene 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /label="rrnG-16S gene" rRNA 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-23S rRNA" gene 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /label="rrnG-23S gene" rRNA 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-5S rRNA" gene 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /label="rrnG-5S gene" S_feature 175915..176523 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176491..176495 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176511..176530 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176525..176681 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176525 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="upshifts" CDS 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" /label="ybaR CDS" gene 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /label="ybaR gene" downshifts 178107 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 178161..178166 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178179..178198 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178197 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="upshifts" CDS 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" /label="ybaS CDS" gene 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /label="ybaS gene" downshifts 179165 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" /label="eesA CDS" gene complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /label="eesA gene" downshifts complement(179218) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" /label="feuC CDS" gene complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /label="feuC gene" CDS complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" /label="feuB CDS" gene complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /label="feuB gene" CDS complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" /label="feuA CDS" gene complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /label="feuA gene" promotor_-35 182282..182288 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182303..182321 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182312 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(182953..182972) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(182960) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" /label="btr CDS" gene complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /label="btr gene" promotor_-10 complement(184643..184662) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(184655) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(184677..184684) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(184764) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" /label="ybbC CDS" gene complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /label="ybbC gene" downshifts complement(184814) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" /label="downshifts" CDS complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" /label="nagZ CDS" gene complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /label="nagZ gene" CDS complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" /label="amiE CDS" gene complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /label="amiE gene" CDS complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" /label="murP CDS" gene complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /label="murP gene" CDS complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" /label="murR CDS" gene complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /label="murR gene" CDS complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" /label="murQ CDS" gene complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /label="murQ gene" promotor_-10 complement(192595..192613) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(192608) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(192629..192636) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" /label="ybbJ CDS" gene complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /label="ybbJ gene" CDS complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" /label="ybbK CDS" gene complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /label="ybbK gene" promotor_-10 complement(193650..193669) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193671) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(193684..193685) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 193744..193751 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 193766..193785 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 193777 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" tRNA 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu2 tRNA" gene 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /label="trnSL-Glu2 gene" tRNA 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val1 tRNA" gene 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /label="trnSL-Val1 gene" tRNA 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Thr1 tRNA" gene 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /label="trnSL-Thr1 gene" tRNA 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Tyr1 tRNA" gene 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /label="trnSL-Tyr1 gene" tRNA 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gln2 tRNA" gene 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /label="trnSL-Gln2 gene" downshifts 194223 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 194268..194385 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194386..194395 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194387 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" promotor_-10 194407..194422 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" /label="sigW CDS" gene 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /label="sigW gene" CDS 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" /label="rsiW CDS" gene 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /label="rsiW gene" downshifts complement(195443) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(195601..195701) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 195631 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" upshifts complement(195641) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 195700..195707 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 195722..195741 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 195731..195811 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 195731 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="upshifts" CDS 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" /label="cdaA CDS" gene 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /label="cdaA gene" CDS 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" /label="cdaR CDS" gene 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /label="cdaR gene" CDS 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" /label="glmM CDS" gene 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /label="glmM gene" downshifts 199437 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 199461..199469 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199477 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 199483..199502 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199529..199534 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199550..199569 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199556 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_feature 199600..199616 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 199613 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" /label="glmSA RNA" gene 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /label="glmSA gene" S_feature 199787..199875 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" /label="glmS CDS" gene 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /label="glmS gene" S_feature complement(201401..>201681) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 201664 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" /label="downshifts" SCAR join(201681,201727) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 201682..201726 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <201727..201845 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" /label="ybdG CDS" gene 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /label="ybdG gene" CDS 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" /label="ybdJ CDS" gene 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /label="ybdJ gene" promotor_-35 203390..203396 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203410..203429 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203428 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" /label="ybdK CDS" gene 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /label="ybdK gene" promotor_-35 204491..204493 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204509..204528 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204512 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" /label="ybzI CDS" gene 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /label="ybzI gene" downshifts 204742 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" /label="ybdM CDS" gene complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /label="ybdM gene" CDS complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" /label="ybdN CDS" gene complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /label="ybdN gene" downshifts complement(205664) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(205713..205732) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(205746..205755) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(205748) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(206512..206531) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206537) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(206546..206553) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206567..206574 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206588..206606 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206590 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="upshifts" CDS 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" /label="ybdO CDS" gene 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /label="ybdO gene" downshifts 207801 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" promotor_-35 207969..207975 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 207989..208008 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208003..208132 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208003 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="upshifts" CDS 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" /label="ybxG CDS" gene 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /label="ybxG gene" downshifts 209529 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" promotor_-35 209567..209573 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209587..209598 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209588 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="upshifts" CDS 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" /label="csgA CDS" gene 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /label="csgA gene" CDS 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" /label="ybxH CDS" gene 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /label="ybxH gene" downshifts 210071 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" /label="ybxI CDS" gene complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /label="ybxI gene" promotor_-10 complement(210941..210959) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(210949) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(210970..210978) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211033..211039 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211054..211072 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211060 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="upshifts" CDS 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" /label="cypC CDS" gene 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /label="cypC gene" misc_feature 211404..211411 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211414 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 212338 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" /label="ybyB CDS" gene complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /label="ybyB gene" downshifts complement(212405) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(212676..212694) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(212685) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(212708..212714) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 212838..212845 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 212855 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 212861..212880 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" /label="ybeC CDS" gene 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /label="ybeC gene" downshifts 214517 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" /label="glpQA CDS" gene complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /label="glpQA gene" downshifts complement(214592) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(215505) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(215514..215530) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215539..215545) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" /label="glpT CDS" gene complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /label="glpT gene" promotor_-35 216543..216552 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216565..217191 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216565..216584 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216565 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216896..216968) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(216928..217028) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(216968) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216970..217056) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217046..217065) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217060) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(217078..217085) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" /label="ybeF CDS" gene 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /label="ybeF gene" promotor_-35 217464..217471 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217471 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 217487..217506 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" /label="ybfA CDS" gene 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /label="ybfA gene" CDS 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" /label="ybfB CDS" gene 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /label="ybfB gene" downshifts 219686 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" /label="ybfEc CDS" gene complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo /label="ybfEc gene" downshifts complement(219784) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" /label="ybfEn CDS" gene complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo /label="ybfEn gene" S_feature complement(220016..220136) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220121..220139) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220136) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(220138..220210) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220156..220161) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" /label="ybfF CDS" gene complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /label="ybfF gene" S_feature complement(221123..221210) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" /label="ybfG CDS" gene complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /label="ybfG gene" misc_feature complement(223444..223462) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223456) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" /label="ybfH CDS" gene complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /label="ybfH gene" CDS complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " /label="ybfI CDS" gene complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /label="ybfI gene" misc_feature complement(225255..225274) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225262) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 225402..225405 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225420..225439 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225425 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="upshifts" CDS 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" /label="purT CDS" gene 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /label="purT gene" downshifts 226594 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 226674..226679 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-35" upshifts 226688 /Source="Nicolas_upshifts" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="upshifts" promotor_-10 226694..226712 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-10" promotor_-35 226728..226735 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 226750..226769 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 226750 /Source="Nicolas_upshifts" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15205417, 15375126, 21819557, 25666135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular glutamyl-endopeptidase" /protein_id="NP_388106.1" /db_xref="EnsemblGenomes-Gn:BSU02240" /db_xref="EnsemblGenomes-Tr:CAB12018" /db_xref="GOA:P39790" /db_xref="InterPro:IPR000126" /db_xref="InterPro:IPR001254" /db_xref="InterPro:IPR008256" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR018114" /db_xref="InterPro:IPR028301" /db_xref="SubtiList:BG10690" /db_xref="UniProtKB/Swiss-Prot:P39790" /translation="MKLVPRFRKQWFAYLTVLCLALAAAVSFGVPAKAAENPQTSVSN TGKEADATKNQTSKADQVSAPYEGTGKTSKSLYGGQTELEKNIQTLQPSSIIGTDERT RISSTTSFPYRATVQLSIKYPNTSSTYGCTGFLVNPNTVVTAGHCVYSQDHGWASTIT AAPGRNGSSYPYGTYSGTMFYSVKGWTESKDTNYDYGAIKLNGSPGNTVGWYGYRTTN SSSPVGLSSSVTGFPCDKTFGTMWSDTKPIRSAETYKLTYTTDTYGCQSGSPVYRNYS DTGQTAIAIHTNGGSSYNLGTRVTNDVFNNIQYWANQ*" /label="mpr CDS" gene 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /label="mpr gene" CDS 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388107.1" /db_xref="EnsemblGenomes-Gn:BSU02250" /db_xref="EnsemblGenomes-Tr:CAB12019" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR019730" /db_xref="SubtiList:BG12739" /db_xref="UniProtKB/Swiss-Prot:O31451" /translation="MYSTIFNIGQINKYSKLAIFMSILFLCGCSSQTHSSQKETTIPV TLHVEDAKGLPVEGVQVTIVKAPSSDEEPSTEIGEILGKTDKNGDIKWDTGRKGDYSV ALTKGETSVTHHISLTEDKKDHAIPLVFKE*" /label="ybfJ CDS" gene 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /label="ybfJ gene" promotor_-10 complement(227753..227767) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(227763) /Source="Nicolas_upshifts" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(227783..227788) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 228046 /Source="Nicolas_upshifts" /id="D85" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.50775" /MaxDrop="5.06025" /score="29.4582027" /energy="-15.4" /TU="U156" /idTUdmin="U157" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 228115..228122 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 228137..228156 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 228150..228224 /Source="Nicolas_S_feature" /locus_tag="new_246583_246657" /HighExp="Cold, LoTm, S0, aero, ferm, T-4.40H, nit, T-5.40H, T-0.40H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S87" upshifts 228150 /Source="Nicolas_upshifts" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" CDS 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /translation="MIQDSMQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKT HIIASGPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAME TRADFAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFIS FHPDVYKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTEN GFPYVFTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLS LEQPEYVNQRVLSFLCGGIK*" /label="cesB CDS" gene 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /label="cesB gene" promotor_-35 228459..228466 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 228475 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 228480..228498 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 229116..229310 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" /label="pssA CDS" gene 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /label="pssA gene" CDS 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" /label="ybfM CDS" gene 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /label="ybfM gene" CDS 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" /label="psd CDS" gene 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /label="psd gene" downshifts 231082 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" /label="ybfN CDS" gene 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /label="ybfN gene" promotor_-35 231483..231492 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 231501 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 231505..231520 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" /label="ybfO CDS" gene 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /label="ybfO gene" downshifts 232886 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" upshifts 232952 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="upshifts" misc_feature 232955..232974 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" /label="ybfP CDS" gene 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /label="ybfP gene" S_feature 233882..234025 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 233997..234004 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 234018..234037 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 234027 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" /label="ybfQ CDS" gene 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /label="ybfQ gene" promotor_-10 complement(234903..234921) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234920) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234937..234942) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 235046 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" /label="downshifts" downshifts complement(235085) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" /label="gltP CDS" gene complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /label="gltP gene" promotor_-10 complement(236363..236381) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236372) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236392..236400) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(236400..236418) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236416) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236434..236439) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" /label="gamP CDS" gene complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /label="gamP gene" downshifts complement(236490) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" misc_feature 238235..238254 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 238252 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" /label="gamA CDS" gene complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /label="gamA gene" S_feature 239112..239293 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(239140..239210) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(239199..239218) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(239214) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(239234..239241) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 239280..239287 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 239295 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 239300..239319 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" /label="gamR CDS" gene 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /label="gamR gene" promotor_-35 240031..240032 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240048..240062 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240058 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="upshifts" CDS 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" /label="ybgB CDS" gene 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /label="ybgB gene" promotor_-10 complement(240157..240175) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(240163) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(240190..240196) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 240366 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 240417..240421 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240437..240456 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240443 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="upshifts" S_feature 240454..240582 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" /label="ilvE CDS" gene 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /label="ilvE gene" downshifts 241642 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" /label="ybgF CDS" gene complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /label="ybgF gene" downshifts complement(241707) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(243103..243214) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(243187..243206) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(243214) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(243221..243228) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" /label="ybgG CDS" gene complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /label="ybgG gene" promotor_-10 complement(244208..244227) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(244225) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="upshifts" promotor_-35 complement(244242..244249) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" /label="glnT CDS" gene complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /label="glnT gene" downshifts complement(244314) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" /label="downshifts" CDS complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" /label="glsA CDS" gene complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /label="glsA gene" promotor_-10 complement(246835..246852) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 246840..246859 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(246842) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 246846 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(246868..246875) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" /label="glnJ CDS" gene 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /label="glnJ gene" CDS 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" /label="glnL CDS" gene 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /label="glnL gene" downshifts 249207 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" promotor_-35 249327..249334 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 249339..249456 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 249339 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 249348..249367 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" /label="kdgD CDS" gene 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /label="kdgD gene" CDS 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" /label="gucD CDS" gene 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /label="gucD gene" CDS 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" /label="gudP CDS" gene 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /label="gudP gene" CDS 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" /label="gudD CDS" gene 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /label="gudD gene" promotor_-35 254748..254755 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 254770..254787 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 254773 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="upshifts" CDS 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" /label="garR CDS" gene 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /label="garR gene" downshifts 255455 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" downshifts 255499 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" /label="garD CDS" gene 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /label="garD gene" promotor_-35 257140..257143 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 257158..257177 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 257170..257404 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 257170 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" /label="ycbJ CDS" gene 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /label="ycbJ gene" promotor_-35 258327..258334 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 258349..258368 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 258359 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" /label="tboW RNA" gene 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /label="tboW gene" downshifts 258598 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" /label="rtpA CDS" gene 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /label="rtpA gene" promotor_no_box 258805..258905 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 258865 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" /label="ycbK CDS" gene 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /label="ycbK gene" downshifts 258953 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 259870..259889 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 259875..259943 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 259875 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="upshifts" CDS 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" /label="ycbL CDS" gene 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /label="ycbL gene" CDS 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" /label="ycbM CDS" gene 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /label="ycbM gene" CDS 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" /label="ycbN CDS" gene 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /label="ycbN gene" S_feature complement(262123..263307) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" /label="ycbO CDS" gene 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /label="ycbO gene" CDS complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" /label="hypothetical protein CDS" gene complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /label="gene" downshifts 263276 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" CDS complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" /label="ycbP CDS" gene complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /label="ycbP gene" downshifts complement(263352) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(263748..263766) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(263767) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(263780..263786) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(263800..264798) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(263843) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" /label="downshifts" promotor_-35 263979..263984 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 263998 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 264000..264018 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264012) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(264014..264028) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(264034) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 complement(264036..264040) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" /label="cwlJ CDS" gene 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /label="cwlJ gene" downshifts 264443 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 264509..264515 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 264528..264547 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 264530 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="upshifts" CDS 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" /label="ycbR CDS" gene 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /label="ycbR gene" promotor_-10 complement(264772..264791) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264798) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(264805..264812) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 265219 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" /label="yczK CDS" gene 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /label="yczK gene" promotor_-35 265511..265517 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 265524..265541 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 265535 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="upshifts" CDS 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" /label="phoD CDS" gene 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /label="phoD gene" promotor_-10 complement(265632..265647) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(265638) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(265660..265669) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" /label="tatAD CDS" gene 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /label="tatAD gene" S_feature 267555..267614 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" /label="tatCD CDS" gene 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /label="tatCD gene" downshifts complement(267623) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" /label="pcp CDS" gene complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /label="pcp gene" promotor_-10 complement(269002..269021) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 269015..269021 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(269016) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(269036..269040) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 269036..269055 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 269038 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="upshifts" CDS 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" /label="ycbU CDS" gene 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /label="ycbU gene" upshifts complement(269412) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(269415..269434) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(269450..269454) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 270172 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" /label="lmrB CDS" gene complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /label="lmrB gene" downshifts complement(270227) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" /label="lmrA CDS" gene complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /label="lmrA gene" promotor_-10 complement(272303..272322) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(272317) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(272337..272344) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 272419..272425 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272441..272458 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272447 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="upshifts" CDS 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" /label="ansZ CDS" gene 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /label="ansZ gene" downshifts 273582 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 273706..273712 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 273726..273745 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 273726 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" /label="estA CDS" gene 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /label="estA gene" downshifts 274396 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" /label="downshifts" S_feature 274441..275031 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" /label="yczC CDS" gene complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /label="yczC gene" downshifts complement(274472) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" Polymorphism join(274645,274647) /Source="geneious" /ID="SNP_BsDelta6_293079_293079" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=186 /Change="C -> T" /Codon_Change="CTG -> CTA" /Coverage=154 /locus_tag="BSU_02710" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" promotor_-10 complement(274861..274880) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(274868) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(274894..274901) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 275003..275006 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 275022..275041 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 275033 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" /label="yccF CDS" gene 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /label="yccF gene" downshifts 276136 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" /label="natK CDS" gene complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /label="natK gene" downshifts complement(276210) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" /label="natR CDS" gene complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /label="natR gene" promotor_-10 complement(277876..277895) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(277882) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(277911..277914) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 277932..277935 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 277951..277970 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 277961 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" /label="natA CDS" gene 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /label="natA gene" CDS 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" /label="natB CDS" gene 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /label="natB gene" promotor_-35 279948..279956 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 279968..279986 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 279968 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" /label="yccK CDS" gene 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /label="yccK gene" CDS complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" /label="ycdA CDS" gene complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /label="ycdA gene" downshifts complement(281006) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(282070..282260) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " /label="hypothetical protein CDS" gene complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /label="gene" promotor_-10 complement(282245..282264) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282265) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(282279..282286) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" /label="ycdB CDS" gene 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /label="ycdB gene" promotor_-10 complement(283858..283876) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(283866) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(283890..283897) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 283922..284001 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 283922 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="upshifts" promotor_-35 283924..283930 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 283945..283962 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" /label="ycdC CDS" gene 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /label="ycdC gene" S_feature 285364..285944 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" /label="cwlK CDS" gene complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /label="cwlK gene" S_feature complement(285875..285956) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 285946 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="upshifts" promotor_-10 complement(285948..285967) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 285949..285968 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(285957) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="upshifts" CDS 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" /label="rapJ CDS" gene 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /label="rapJ gene" downshifts 287112 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 287159..287165 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 287180..287198 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 287183 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" /label="ycdF CDS" gene 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /label="ycdF gene" downshifts complement(287232) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" /label="downshifts" CDS 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" /label="ycdG CDS" gene 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /label="ycdG gene" promotor_no_box 288966..289066 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 289026 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 289092 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" /label="downshifts" downshifts 289708 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" promotor_-35 289802..289809 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 289825..289844 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 289831 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" /label="znuA CDS" gene 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /label="znuA gene" promotor_-35 290454..290460 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290474..290493 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290478 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" downshifts 290830 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" /label="znuC CDS" gene 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /label="znuC gene" CDS 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" /label="znuB CDS" gene 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /label="znuB gene" downshifts 292396 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" /label="yceB CDS" gene complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /label="yceB gene" promotor_-35 293398..293405 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 293420..293439 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 293426..293628 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 293426 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="upshifts" promotor_-10 complement(293474..293493) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(293482) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(293508..293515) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 293612..293621 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 293630..293725 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 293630 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 293634..293649 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" /label="yceC CDS" gene 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /label="yceC gene" CDS 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" /label="yceD CDS" gene 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /label="yceD gene" CDS 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" /label="yceE CDS" gene 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /label="yceE gene" CDS 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" /label="yceF CDS" gene 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /label="yceF gene" downshifts 296352 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" /label="downshifts" CDS 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" /label="yceG CDS" gene 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /label="yceG gene" CDS 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" /label="yceH CDS" gene 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /label="yceH gene" downshifts 299144 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" /label="downshifts" promotor_-35 299224..299231 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 299246..299265 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 299254 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="upshifts" CDS 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" /label="niaP CDS" gene 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /label="niaP gene" downshifts 300474 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" /label="yceJ CDS" gene complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /label="yceJ gene" downshifts complement(300762) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" /label="yceK CDS" gene complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /label="yceK gene" downshifts complement(302016) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(302273..302292) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(302292) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(302306..302312) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 302539..302558 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 302539 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="upshifts" CDS 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" /label="opuAA CDS" gene 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /label="opuAA gene" downshifts complement(302588) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" /label="downshifts" CDS 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" /label="opuAB CDS" gene 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /label="opuAB gene" CDS 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" /label="opuAC CDS" gene 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /label="opuAC gene" downshifts 305548 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(305580) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" /label="amhX CDS" gene complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /label="amhX gene" downshifts complement(305624) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" S_feature complement(306757..306844) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 306812..306819 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(306831..306850) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 306834..306853 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(306844) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="upshifts" upshifts 306847 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="upshifts" promotor_-35 complement(306863..306869) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" /label="ycgA CDS" gene 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /label="ycgA gene" promotor_-35 307644..307652 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 307664..307682 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 307683 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 308321 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 308382..308389 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308404..308423 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308413 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" /label="ycgB CDS" gene 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /label="ycgB gene" upshifts 308849 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" misc_feature 308853..308857 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 309012..309019 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 309034..309053 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 309047..309184 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 309047 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" /label="amyE CDS" gene 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /label="amyE gene" downshifts 311178 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 311244..311251 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 311261 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 311265..311284 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" /label="lctE CDS" gene 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /label="lctE gene" CDS 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" /label="lctP CDS" gene 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /label="lctP gene" downshifts 312344 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" /label="downshifts" downshifts 313950 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" /label="mdr CDS" gene complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /label="mdr gene" downshifts complement(314026) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(314600..314700) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(314640) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 315560..315564 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315580..315599 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315594 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(315626..315645) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(315629) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="upshifts" CDS 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" /label="ycgE CDS" gene 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /label="ycgE gene" promotor_-35 complement(315660..315666) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 316133..316138 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316154..316172 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316164 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" /label="ycgF CDS" gene 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /label="ycgF gene" promotor_-35 316837..316846 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316860..316879 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316868 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" /label="ycgG CDS" gene 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /label="ycgG gene" S_feature complement(317296..317658) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 317654 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" /label="ycgH CDS" gene complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /label="ycgH gene" promotor_-10 complement(319026..319037) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319036) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(319052..319058) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 319078..319084 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319092 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 319099..319110 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" /label="ycgI CDS" gene 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /label="ycgI gene" promotor_-35 319733..319740 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 319754..319854 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 319754..319773 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 319754 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(319850) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" /label="nadE CDS" gene 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /label="nadE gene" downshifts 320655 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" /label="downshifts" CDS complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" /label="tmrB CDS" gene complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /label="tmrB gene" downshifts complement(320730) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(321331..321350) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(321346) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(321365..321368) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(321374..321522) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 321424..321431 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 321444..321463 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 321446..321554 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 321448 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(321516..321534) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321522..321529 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321532) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 321544..321563 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321550..321555) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321556 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="upshifts" CDS 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" /label="aroK CDS" gene 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /label="aroK gene" downshifts 322129 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" /label="ycgJ CDS" gene complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /label="ycgJ gene" downshifts complement(322204) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(322973..322992) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 322974..322981 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(322979) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 322996..323015 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(323007..323012) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 323008 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" CDS 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" /label="ycgK CDS" gene 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /label="ycgK gene" S_feature 324034..324104 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" /label="cah CDS" gene 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /label="cah gene" promotor_-35 324520..324526 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324541..324552 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324548 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" S_feature 325062..325140 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 325115..325120 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 325137..325155 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 325142 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" CDS 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" /label="ycgL CDS" gene 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /label="ycgL gene" downshifts 325892 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 325937..326064 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 326041..326045 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326060..326079 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326066 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" /label="putB CDS" gene 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /label="putB gene" CDS 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" /label="putC CDS" gene 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /label="putC gene" promotor_-35 328017..328023 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328037..328056 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328045 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 328128..328134 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328147..328166 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328156 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" misc_feature 328592..328596 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 328594..328716 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 328596 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" /label="putP CDS" gene 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /label="putP gene" S_feature complement(329237..331092) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 330118 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" /label="downshifts" S_feature 330163..330259 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 330230..330237 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 330252..330271 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 330261 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" /label="putR CDS" gene 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /label="putR gene" promotor_-10 complement(331085..331103) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(331102) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(331117..331124) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(331510) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" /label="ycgQ CDS" gene complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /label="ycgQ gene" downshifts complement(331576) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" /label="ycgR CDS" gene complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /label="ycgR gene" upshifts complement(333361) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(333366..333379) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(333394..333402) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" /label="ycgS CDS" gene complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /label="ycgS gene" promotor_-10 complement(334282..334301) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(334302) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="upshifts" promotor_-35 complement(334316..334319) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 334353..334372 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(334353..334371) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 334360..334424 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 334361 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(334370) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(334387..334392) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" /label="ffoR CDS" gene 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /label="ffoR gene" S_feature 335436..337883 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" /label="nasF CDS" gene complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /label="nasF gene" downshifts complement(335471) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" /label="nasE CDS" gene complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /label="nasE gene" promotor_-35 337150..337155 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 337169..337173 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 337176 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(337208) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(337210..337229) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(337243..337250) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" /label="nasD CDS" gene complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /label="nasD gene" promotor_-10 complement(339773..339792) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(339787) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(339804..339810) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" /label="nasC CDS" gene complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /label="nasC gene" CDS complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" /label="nasB CDS" gene complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /label="nasB gene" promotor_no_box complement(344343..344443) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(344383) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 344426..344433 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 344447..344466 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 344459 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="upshifts" CDS 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" /label="nasA CDS" gene 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /label="nasA gene" downshifts 345694 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 345753..345759 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 345774..345793 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 345782 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="upshifts" CDS 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" /label="folEB CDS" gene 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /label="folEB gene" CDS 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" /label="yciB CDS" gene 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /label="yciB gene" promotor_-35 347332..347339 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 347353..347372 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 347363 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="upshifts" CDS 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" /label="yczL CDS" gene 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /label="yczL gene" CDS 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" /label="zinU CDS" gene 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /label="zinU gene" downshifts 348815 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" S_feature 348860..350529 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" /label="yckA CDS" gene complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /label="yckA gene" downshifts complement(348878) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" /label="yckB CDS" gene complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /label="yckB gene" promotor_-10 complement(350447..350466) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(350459) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(350461..353295) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(350481..350488) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 350498..350504 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350519..350537 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 350531..350753 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 350531 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" /label="hypothetical protein CDS" gene 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /label="gene" promotor_-35 350722..350727 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350743..350761 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 350755 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" /label="yckC CDS" gene 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /label="yckC gene" downshifts 351233 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 351281..351287 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 351294 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 351301..351312 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" /label="yckD CDS" gene 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /label="yckD gene" downshifts 351653 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 351758..351765 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 351781..351800 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 351785 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="upshifts" CDS 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" /label="bglC CDS" gene 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /label="bglC gene" downshifts 353237 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" /label="nin CDS" gene complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /label="nin gene" promotor_no_box complement(353691..353791) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" /label="nucA CDS" gene complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /label="nucA gene" upshifts complement(353731) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(354185..354204) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(354193) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(354195..354337) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(354218..354225) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" /label="tlpC CDS" gene complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /label="tlpC gene" promotor_-35 354350..354357 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 354368..357511 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 354368 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 354372..354391 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(354373..354473) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(354413) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="upshifts" promotor_-10 complement(356083..356101) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(356098) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="upshifts" promotor_-35 complement(356115..356122) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" /label="hxlB CDS" gene complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /label="hxlB gene" downshifts complement(356173) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" /label="hxlA CDS" gene complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /label="hxlA gene" promotor_-10 complement(357391..357410) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(357406) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(357425..357428) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 357489..357492 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 357507..357526 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 357513 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="upshifts" CDS 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" /label="hxlR CDS" gene 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /label="hxlR gene" downshifts 357945 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 358208..358211 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 358226..358245 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 358234..358534 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 358234 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="upshifts" CDS 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" /label="srfAA CDS" gene 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /label="srfAA gene" CDS 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" /label="srfAB CDS" gene 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /label="srfAB gene" CDS 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" CDS 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" /label="srfAC CDS" gene 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /label="srfAC gene" CDS 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" /label="srfAD CDS" gene 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /label="srfAD gene" downshifts 384665 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" /label="downshifts" promotor_-35 384721..384728 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 384731 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 384740..384759 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" /label="srfT CDS" gene 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /label="srfT gene" downshifts 386004 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" /label="ycxB CDS" gene complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /label="ycxB gene" promotor_no_box complement(386040..386140) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(386062) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" /label="downshifts" upshifts complement(386080) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(386611..386630) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(386613) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" /label="ycxC CDS" gene complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /label="ycxC gene" promotor_-10 complement(387613..387631) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(387620) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(387647..387652) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" /label="ycxD CDS" gene 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /label="ycxD gene" CDS complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" /label="sfpAc CDS" gene complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo /label="sfpAc gene" CDS complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" /label="sfpAn CDS" gene complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo /label="sfpAn gene" misc_feature complement(389729..389748) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(389741) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" CDS complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" /label="yczE CDS" gene complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /label="yczE gene" promotor_-10 complement(390483..390502) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(390486) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(390518..390522) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(390623..390774) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" /label="tcyC CDS" gene complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /label="tcyC gene" downshifts complement(390831) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" /label="tcyB CDS" gene complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /label="tcyB gene" CDS complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" /label="tcyA CDS" gene complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /label="tcyA gene" promotor_-10 complement(393078..393097) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393090) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393111..393118) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" /label="bsdA CDS" gene complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /label="bsdA gene" promotor_-10 complement(393755..393773) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393762) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393788..393794) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 394071..394078 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(394086..394105) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 394092..394111 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(394092) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="upshifts" upshifts 394100 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="upshifts" CDS 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" /label="ubiX CDS" gene 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /label="ubiX gene" promotor_-35 complement(394119..394126) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" /label="bsdC CDS" gene 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /label="bsdC gene" CDS 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" /label="bsdD CDS" gene 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /label="bsdD gene" CDS 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" /label="yclD CDS" gene 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /label="yclD gene" downshifts 396831 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 396857..396858 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 396858 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" /label="yclE CDS" gene 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /label="yclE gene" CDS complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" /label="dtpT CDS" gene complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /label="dtpT gene" downshifts complement(397810) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 399307..399309 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399308..399327) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399318 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 399326..399344 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399328) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(399330..399834) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(399342..399349) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 399498..399507 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 399520..399539 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399521 /Source="Nicolas_upshifts" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="upshifts" CDS 399560..401314 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative uronase" /protein_id="NP_388250.1" /db_xref="EnsemblGenomes-Gn:BSU03680" /db_xref="EnsemblGenomes-Tr:CAB12176" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG12028" /db_xref="UniProtKB/Swiss-Prot:P94409" /translation="MAEFILNAADFGVPRDGKTDSTERINQCLSTAVSKGYHTVWFPK GTYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQEN ITISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVS PRGLKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPK FGIDIEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYG YGTQTVIKGNILRRPEDAAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRG KSVLVTNNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLN NCLIQVVDGVNVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNTLNPDAFEAVPESYS VSVTNNAGAIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIF DNTISVNRTAGNPIVIYLNGSAGSIISGNTINNLSAGTATAIQTNTSTNSKIIGNRIF KGTINKHSSDTIDGNMIV*" /label="yclG CDS" gene 399560..401314 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /label="yclG gene" promotor_-10 complement(399831..399849) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399844) /Source="Nicolas_upshifts" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(399865..399870) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 401305 /Source="Nicolas_upshifts" /id="D160" /incds=0 /nref=6 /ntot=21 /MaxReadThrough="0.325519999999999" /MaxDrop="4.9689" /score="4.29139266" /energy="-5.4" /TU="NA" /idTUdmin="U282" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(401330..401551) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388251.1" /db_xref="EnsemblGenomes-Gn:BSU03690" /db_xref="EnsemblGenomes-Tr:CAB12177" /db_xref="GOA:O31479" /db_xref="SubtiList:BG12780" /db_xref="UniProtKB/Swiss-Prot:O31479" /translation="MKILGVTGFILICLLAISVLMDMLQGFSLTKAVYNNMSSFKMTT FAEWVVLLFFVLVLVREMYVIYKSKKKNP*" /label="yczF CDS" gene complement(401330..401551) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /label="yczF gene" promotor_-10 complement(401570..401581) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(401572) /Source="Nicolas_upshifts" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(401596..401602) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 401617..401623 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 401637..401648 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 401650 /Source="Nicolas_upshifts" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="upshifts" CDS 401677..403311 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388252.1" /db_xref="EnsemblGenomes-Gn:BSU03700" /db_xref="EnsemblGenomes-Tr:CAB12178" /db_xref="GOA:P49939" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG11392" /db_xref="UniProtKB/Swiss-Prot:P49939" /translation="MPLFSKRKNNTDSKDKQNTDERNQEQQQEKERPVLISPSLAKNI AETKKEVGSSSDVIIREIKIGEQDHVHLAVIYISGLVDNNTIHESLIDPLVQDESIQN THAIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSI QEPSTQVSFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQG ICDEKVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLE GRFAIIVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAVY VAATTFHQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRLPRVVGSA VSIVGALVIGQAAVQAGIVSPAMVIIVALTAIASFATPAFAMAISARLIRFIFIIASA VMGFYGLILGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRVPWWADEKRPES VSKEDKVRQGKDQRPEPAASRGMVNKDLEEGDQNGT*" /label="gerKA CDS" gene 401677..403311 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /label="gerKA gene" CDS 403301..404524 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944, 19363077; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388253.1" /db_xref="EnsemblGenomes-Gn:BSU03710" /db_xref="EnsemblGenomes-Tr:CAB12179" /db_xref="GOA:P49941" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG11394" /db_xref="UniProtKB/Swiss-Prot:P49941" /translation="MVRKCLLAVLMLLSVIVLPGCWDKRELTDLAIISAIGIDRTNDS NYVLHLQIINPGNVAGGLQGGGAGDRPPVSVYSIEGNNITEALRKASMKVSRRLYFAH TNLVVINEKLAKEEGLDFVLDNLDRDTEFRTTATFVVAHKTKAENIVKILTPIDKIPS NKVNKTLDFTEAQYGRVVKINIQDVLKTLAANTMAPVIPGYMMIGDDKKGVSMENTQA TDPKAILQADGLAVFDKAGYLKYWLEDDESVGAVWLMNKIQHTFINADWGKTKDAVSL QVTHQDTKLVPKMRNGRPYIHVKVSVEGIIDAVKYPFQLSDPKVLAAIEKALNKELEK EISHTVKKIKKNKIDFIGFGDTIYRKYPEQWEKMKDTWDKEYLPELPIDVKAETYIRR TGLRNNPIKHQFKDD*" /label="gerKC CDS" gene 403301..404524 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /label="gerKC gene" CDS 404549..405670 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 15849754, 16707705, 16740944, 16850406, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 15849754, 16707705, 16740944, 16850406, 19363077; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388254.1" /db_xref="EnsemblGenomes-Gn:BSU03720" /db_xref="EnsemblGenomes-Tr:CAB12180" /db_xref="GOA:P49940" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG11393" /db_xref="UniProtKB/Swiss-Prot:P49940" /translation="MEKARISIRQLFVMIIIFELGSSLLITPGSMAGRDAWIAVLLGC AIGLFLFYLYQGIYQCYPNSSPKEYMDDMLGTKLSWLFSFLYILYFAYIAARVLRDFG EMLLTFAYHDTPIIIVNALLMVVSIYAVRKGIEVLARAAELLFGAMYLLGAIGLVLII VSGTIDPHNLKPVLANGISPVLHSVFTQTMYVPFGEVVLFVMIFPNLNDRKDVKKMGM IAMAISGLIVALTVAINISVLDVDLTLRSQFPLLSTIQTIKVEEFLDRLDVFFMLALI IGGFFKVSLYLYATVVGTSTLFKEKNPSQLAYPMGLGILILSITIATNFSEHLNEGLN VVPLYIHLPFQLLFPLFLFIVAVWKKKRREKSKGEEAKK*" /label="gerKB CDS" gene 404549..405670 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /label="gerKB gene" downshifts 405654 /Source="Nicolas_upshifts" /id="D161" /incds=0 /nref=6 /ntot=58 /MaxReadThrough="2.55658" /MaxDrop="3.73002" /score="3.39927899" /energy="-10.5" /TU="NA" /idTUdmin="U285" /TUdmin=2200 /isTUend="FALSE" /label="downshifts" CDS complement(405775..406455) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATPase component)" /protein_id="NP_388255.1" /db_xref="EnsemblGenomes-Gn:BSU03730" /db_xref="EnsemblGenomes-Tr:CAB12181" /db_xref="GOA:P94411" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12029" /db_xref="UniProtKB/Swiss-Prot:P94411" /translation="MSLLQFQQVGYWYKNKSQPLFQDINISFQKGKFYTIVGTSGTGK TTFLSLAGGLDAPKEGNILYDGKAVSKIGLTNFRNQYVSIVFQAYNLLPYMTALQNVT TAMEITGSKEKNKESYALDMLQKVGINEKQARQKVLTLSGGQQQRVSITRAFCCDTDL IVADEPTGNLDEDTSKEIVRLFQDLAHKEDKCVIMVTHDEQIAKVSDINIRLSRGSFT VKENVAVV*" /label="yclH CDS" gene complement(405775..406455) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /label="yclH gene" CDS complement(406471..407931) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388256.2" /db_xref="EnsemblGenomes-Gn:BSU03740" /db_xref="EnsemblGenomes-Tr:CAB12182" /db_xref="GOA:P94412" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG12030" /db_xref="UniProtKB/Swiss-Prot:P94412" /translation="MNFIKRAFWNMKAKKGKTLLQLFVFTVICVFVLSGLAIQSAAQK SSELARQELGGSVTLQVDRQKQMEKQQDSGEKRSFESTPIKVSDANKLAALDHVKSYN YTTSASANAGNFDAIESSSSSDSSSSSSSSNAKNSQGGGQGGPQMVQADLSIEGVIST ALVDDFSDGDSKITDGRAITKSDVGKKVTVINETLAEENDLSVGDSITIESATDEDTT VKLKIVGIYKTTSSGDDQAQNFSFLNPYNKLYTPYTATAALKGDDYKNTIDSAVYYMD DAKNMDTFVKAAKKTSIDFDTYTLNTNDQLYQQMVGPIENVASFSKNVVYLVSVAGAV ILGLIVMMSIRERKYEMGVLMAIGEKRWKLIGQFLTEILIVAVIAIGLASVTGNLVAN QLGNQLLSQQISSSTDSTQTASGQMPGGGGGMGGKMFGHSSSNVDVIDSLNVAVSMND MLILGGIGILIAIIATLLPSISVLRLHPKTILTKQE*" /label="yclI CDS" gene complement(406471..407931) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /label="yclI gene" misc_feature 408101..408120 /Source="Nicolas_upshift_promotors" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 408104 /Source="Nicolas_upshifts" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="upshifts" CDS 408144..408827 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /function="16.10: Respire" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YclK] (possibly involved in arabinogalactan metabolism)" /protein_id="NP_388257.1" /db_xref="EnsemblGenomes-Gn:BSU03750" /db_xref="EnsemblGenomes-Tr:CAB12183" /db_xref="GOA:P94413" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12031" /db_xref="UniProtKB/Swiss-Prot:P94413" /translation="MKILMIEDNVSVCTMTEMFFFKEGFEAEFVHDGLEGYQRFTEEN WDLIILDIMLPSMDGVTICRKIRETSTVPIIMLTAKDTESDQVIGFEMGADDYVTKPF SPLTLVARIKAVIRRYKATGKAVIDEDMIETECFTINKKTREVLLNGEPVENLTPKEF DLLYYLVQNPRQVFSREQLLEQVWGYQFYGDERTVDVHIKRLRKKLASEDKPFLYTVW GVGYKFDED*" /label="yclJ CDS" gene 408144..408827 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /label="yclJ gene" CDS 408814..410235 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /function="16.3: Control" /function="16.10: Respire" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YclJ]" /protein_id="NP_388258.1" /db_xref="EnsemblGenomes-Gn:BSU03760" /db_xref="EnsemblGenomes-Tr:CAB12184" /db_xref="GOA:P94414" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12032" /db_xref="UniProtKB/Swiss-Prot:P94414" /translation="MMKIKYLYQLLLSHISILILAFVIIISLFSHFVKEFAYQNKVEE LTSYAVQIANEFQSGQVDMRRLYPYQDILSTRKTQFIIFNEEQQPYFLPEGFHHPPRE QLKKSEWNKLKKGQTVTIRADGRFDDEVSLVAQPIFVQNEFKGAVLLISPISGVEQMV NQVNLYMFYAVISTLVITILVSWLLSKFHVKRIQKLREATDKVASGDYDIHLENSYGD EIGVLASDFNIMAKKLKQSRDEIERLEKRRRQFIADVSHELKTPLTTINGLVEGLNSH TIPEDKKDKCFSLISEETKRMLRLVKENLDYEKIRSQQITLNKLDVPLIEVFEIVKEH LQQQAEEKQNKLMIQVEDHVIVHADYDRFIQILVNITKNSIQFTQNGDIWLRGMEGYK ETIIEIEDTGIGIPKEDIEHIWERFYKADISRTNTAYGEYGLGLSIVRQLVEMHQGTV EIKSEEGKGTKFIIRLPLTAKQQ*" /label="yclK CDS" gene 408814..410235 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /label="yclK gene" downshifts 410211 /Source="Nicolas_upshifts" /id="D162" /incds=0 /nref=20 /ntot=169 /MaxReadThrough="3.43905" /MaxDrop="4.91565" /score="13.4599201" /energy="-15" /TU="U286" /idTUdmin="U286" /TUdmin="-1427" /isTUend="FALSE" /label="downshifts" S_feature 410256..410360 /Source="Nicolas_S_feature" /locus_tag="new_428689_428793" /HighExp="Lbstat, nit, ferm, BI, M0t45, M40t45, M0t90, S0, S2, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S129" misc_feature 410350..410369 /Source="Nicolas_upshift_promotors" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 410362 /Source="Nicolas_upshifts" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(410394) /Source="Nicolas_upshifts" /id="D163" /incds=0 /nref=2 /ntot=81 /MaxReadThrough="1.74985" /MaxDrop="4.10695" /score="1.47729412" /energy="-10.3" /TU="NA" /idTUdmin="U290" /TUdmin=1320 /isTUend="FALSE" /label="downshifts" CDS 410398..411546 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 15968044, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 15968044, 19202088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388259.1" /db_xref="EnsemblGenomes-Gn:BSU03770" /db_xref="EnsemblGenomes-Tr:CAB12185" /db_xref="GOA:P94415" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11966" /db_xref="UniProtKB/Swiss-Prot:P94415" /translation="MKSGVIPSSAVGQKINEWYRYIRTFSVPDAEVLKAEIQQELKHM QHDSNLLLYYSLMEFRHQLMLDYLEPLEKLNIEDQPSLSELSRNIDSNQADLKGLLDY YVNFFRGMYEFDKREFISAITYYKQAEKKLSFVADHIERAEFYFKIAEAYYYMKQTYF SLINIKNAYEIYVEQETYNVRIIQCHFVFGVNLMDERNFEQAARHFKLALNMAQAEQK AQLVGRAYYNLGLCYYNQDLLDPAIDYFEKAVSTFESSRIVNSLPQAYFLITLIYYKQ GKHDKASEYHKRGYEYAKETDDADYAVKFEFLQSLYLDQPNEEGIERCFQYLKNKNMY ADIEDLALEVAKYYYEQKWFKLSASYFLQVEEARKQIQRSEGLYEIEI*" /label="rapC CDS" gene 410398..411546 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /label="rapC gene" promotor_-35 411246..411251 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 411264 /Source="Nicolas_upshifts" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 411268..411286 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 411408..411416 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 411428..411446 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411440 /Source="Nicolas_upshifts" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="upshifts" CDS 411530..411652 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 16816200, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 16816200, 19202088; Product type r : regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapC and competence and sporulation stimulating factor (CSF)" /protein_id="NP_388260.1" /db_xref="EnsemblGenomes-Gn:BSU03780" /db_xref="EnsemblGenomes-Tr:CAB12186" /db_xref="GOA:P94416" /db_xref="InterPro:IPR020243" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11959" /db_xref="UniProtKB/Swiss-Prot:P94416" /translation="MKLKSKLFVICLAAAAIFTAAGVSANAEALDFHVTERGMT*" /label="phrC CDS" gene 411530..411652 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /label="phrC gene" downshifts 411639 /Source="Nicolas_upshifts" /id="D164" /incds=0 /nref=260 /ntot=275 /MaxReadThrough="3.24518" /MaxDrop="7.70367" /score="26.3182765" /energy="-14" /TU="NA" /idTUdmin="U286" /TUdmin=1 /isTUend="TRUE" /label="downshifts" downshifts complement(411707) /Source="Nicolas_upshifts" /id="D165" /incds=0 /nref=3 /ntot=64 /MaxReadThrough="0.60499" /MaxDrop="7.4475" /score="-1.25354129" /energy="-15.8" /TU="NA" /idTUdmin="U290" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(411752..411841) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097676.1" /db_xref="EnsemblGenomes-Gn:BSU03788" /db_xref="EnsemblGenomes-Tr:CAX52547" /db_xref="GOA:C0H3V0" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V0" /translation="MSGYGTSFALIVVLFILLIIVGTAFVGGY*" /label="yczM CDS" gene complement(411752..411841) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /label="yczM gene" downshifts complement(411912) /Source="Nicolas_upshifts" /id="D166" /incds=0 /nref=25 /ntot=113 /MaxReadThrough="7.05273" /MaxDrop="3.3619" /score="32.1465401" /energy="-16.5" /TU="U290" /idTUdmin="U290" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(411923..412036) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore and germination protein" /protein_id="YP_003097677.1" /db_xref="EnsemblGenomes-Gn:BSU03789" /db_xref="EnsemblGenomes-Tr:CAX52548" /db_xref="GOA:C0H3V1" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V1" /translation="MSGYSNGGGYGGISSFALIVVLFILLIIVGTAFVGGF*" /label="yczN CDS" gene complement(411923..412036) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /label="yczN gene" promotor_-10 complement(412057..412076) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(412068) /Source="Nicolas_upshifts" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(412089..412098) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(412190..413554) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2152900, 11471740, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2152900, 11471740, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate kinase III" /protein_id="NP_388261.1" /db_xref="EnsemblGenomes-Gn:BSU03790" /db_xref="EnsemblGenomes-Tr:CAB12187" /db_xref="GOA:P94417" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR035804" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12033" /db_xref="UniProtKB/Swiss-Prot:P94417" /translation="MKVVKFGGSSLASGAQLDKVFHIVTSDPARKAVVVSAPGKHYAE DTKVTDLLIACAEQYLATGSAPELAEAVVERYALIANELQLGQSIIEKIRDDLFTLLE GDKSNPEQYLDAVKASGEDNNAKLIAAYFRYKGVKAEYVNPKDAGLFVTNEPGNAQVL PESYQNLYRLRERDGLIIFPGFFGFSKDGDVITFSRSGSDITGSILANGLQADLYENF TDVDAVYSVNPSFVENPKEISELTYREMRELSYAGFSVFHDEALIPAFRAGIPVQIKN TNNPSAEGTRVVSKRDNTNGPVVGIASDTGFCSIYISKYLMNREIGFGRRALQILEEH GLTYEHVPSGIDDMTIILRQGQMDAATERSVIKRIEEDLHADEVIVEHHLALIMVVGE AMRHNVGTTARAAKALSEAQVNIEMINQGSSEVSMMFGVKEAEERKAVQALYQEFFAG VLIS*" /label="thrD CDS" gene complement(412190..413554) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /label="thrD gene" downshifts complement(412198) /Source="Nicolas_upshifts" /id="D167" /incds=0 /nref=23 /ntot=129 /MaxReadThrough="2.21842" /MaxDrop="4.81019" /score="44.9085917" /energy="-15" /TU="NA" /idTUdmin="U291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(412242) /Source="Nicolas_upshifts" /id="D168" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="5.53807" /MaxDrop="2.54279" /score="44.9085917" /energy="-15" /TU="U291" /idTUdmin="U291" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(413590..413609) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(413606) /Source="Nicolas_upshifts" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(413624..413631) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 413745..413749 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413765..413784 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413777 /Source="Nicolas_upshifts" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 413808..413815 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413829..413848 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 413838..413938 /Source="Nicolas_S_feature" /locus_tag="new_432271_432371" /HighExp="LBGexp, Lbexp, G150, dia0, G135, H2O2, Paraq, dia15, G180, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S130" upshifts 413838 /Source="Nicolas_upshifts" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="upshifts" CDS 413939..414889 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388262.1" /db_xref="EnsemblGenomes-Gn:BSU03800" /db_xref="EnsemblGenomes-Tr:CAB12188" /db_xref="GOA:P94418" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12034" /db_xref="UniProtKB/Swiss-Prot:P94418" /translation="MKLRYLFILLIILAVTSVFIGVEDLSPLDLFDLSKQEASTLFAS RLPRLISIVIAGLSMSICGLIMQQISRNKFVSPTTAGTMDWARLGILISLLLFTSASP LIKMLVAFVFALAGNFLFMKILERIKFNDTIFIPLVGLMLGNIVSSIATFIAYKYDLI QNVSSWLQGDFSLVVKGRYELLYLSIPLVIIAYVYADKFTLAGMGESFSVNLGLKYKR VVNIGLIIVSLITSLVILTVGMLPFLGLIIPNIVSIYRGDNLKSSLPHTVLLGAVFVL FCDILGRIIIFPYEISIGLMVGIIGSGIFLFMLLRRKAYA*" /label="pbtN CDS" gene 413939..414889 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /label="pbtN gene" CDS 414882..415829 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388263.1" /db_xref="EnsemblGenomes-Gn:BSU03810" /db_xref="EnsemblGenomes-Tr:CAB12189" /db_xref="GOA:P94419" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12035" /db_xref="UniProtKB/Swiss-Prot:P94419" /translation="MRNQMKIALLVGLAIVCIGLFLFYDLGNWDYTLPRRIKKVAAIV LTGGAIAFSTMIFQTITNNRILTPSILGLDSLYMLIQTGIIFLFGSANMVIMNKNINF IISVLLMILFSLVLYQIMFKGEGRNIFFLLLIGIVFGTLFSSLSSFMQMLIDPNEFQV VQDKMFASFNNINTDLLWLAFIIFLLTGVYVWRFTKFFDVLSLGREHAVNLGIDYDKV VKQMLIVVAILVSVSTALVGPIMFLGLLVVNLAREFLKTYKHSYLIAGSVFISIIALV GGQFVVEKVFTFSTTLSVIINFAGGIYFIYLLLKENKSW*" /label="pbtO CDS" gene 414882..415829 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /label="pbtO gene" CDS 415823..416581 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (ATP-binding protein)" /protein_id="NP_388264.1" /db_xref="EnsemblGenomes-Gn:BSU03820" /db_xref="EnsemblGenomes-Tr:CAB12190" /db_xref="GOA:P94420" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12036" /db_xref="UniProtKB/Swiss-Prot:P94420" /translation="MVEVRNVSKQYGGKVVLEETSVTIQKGKITSFIGPNGAGKSTLL SIMSRLIKKDSGEIYIDGQEIGACDSKELAKKMSILKQANQINIRLTIKDLVSFGRFP YSQGRLTEEDWVHINQALSYMKLEDIQDKYLDQLSGGQCQRAFIAMVIAQDTDYIFLD EPLNNLDMKHSVEIMKLLKRLVEELGKTIVIVIHDINFASVYSDYIVALKNGRIVKEG PPEEMIETSVLEEIYDMTIPIQTIDNQRIGVYFS*" /label="pbtP CDS" gene 415823..416581 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /label="pbtP gene" CDS 416603..417556 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416, 25355936; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (binding lipoprotein)" /protein_id="NP_388265.1" /db_xref="EnsemblGenomes-Gn:BSU03830" /db_xref="EnsemblGenomes-Tr:CAB12191" /db_xref="GOA:P94421" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR033870" /db_xref="PDB:3GFV" /db_xref="SubtiList:BG12037" /db_xref="UniProtKB/Swiss-Prot:P94421" /translation="MKKFALLFIALVTAVVISACGNQSTSSKGSDTKKEQITVKHQLD KNGTKVPKNPKKVVVFDFGSLDTLDKLGLDDIVAGLPKQVLPKYLSKFKDDKYADVGS LKEPDFDKVAELDPDLIIISARQSESYKEFSKIAPTIYLGVDTAKYMESFKSDAETIG KIFDKEDKVKDELANIDHSIADVKKTAEKLNKNGLVIMANDGKISAFGPKSRYGLIHD VFGVAPADQNIKASTHGQSVSYEYISKTNPDYLFVIDRGTAIGETSSTKQVVENDYVK NVNAVKNGHVIYLDSATWYLSGGGLESMTQMIKEVKDGLEK*" /label="pbtQ CDS" gene 416603..417556 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /label="pbtQ gene" downshifts 417539 /Source="Nicolas_upshifts" /id="D169" /incds=0 /nref=161 /ntot=280 /MaxReadThrough="3.87669" /MaxDrop="7.4722" /score="31.9942335" /energy="-13.8" /TU="U293" /idTUdmin="U292" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(417603..419021) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15855514, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388266.1" /db_xref="EnsemblGenomes-Gn:BSU03840" /db_xref="EnsemblGenomes-Tr:CAB12192" /db_xref="GOA:P94422" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12038" /db_xref="UniProtKB/Swiss-Prot:P94422" /translation="MNTSIEQKPFNRSVIVGILLAGAFVAILNQTLLITALPHIMRDF NVDANQAQWLTTSFMLTNGILIPITAFLIEKFTSRALLITAMSIFTAGTVVGAFAPNF PVLLTARIIQAAGAGIMMPLMQTVFLTIFPIEKRGQAMGMVGLVISFAPAIGPTLSGW AVEAFSWRSLFYIILPFAVIDLILASILMKNVTTLRKTQIDILSVILSTFGFGGLLYG FSSVGSYGWSSSTVLISLLVGVIALLLFITRQMKLKKPMLEFRVFTFGVFSLTTLLGT LVFALLIGTETILPLYTQNVRDVTAFDTGLMLLPGAVVMGFMSPIIGRIFDRVGGRGL AIAGFCIIFLTSLPFMQLTDHTSLAWIVVLYTVRLLGTAMIMMPVTTAGINALPRHLI PHGTAMNNTIRQVGGSIGTALLVSVMSNQAAHAGTTNVKHAALHGMNAAFIVAAVIAL VGFLLSFTLKKPQRPAEQQPAR*" /label="ycnB CDS" gene complement(417603..419021) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /label="ycnB gene" downshifts complement(417624) /Source="Nicolas_upshifts" /id="D170" /incds=0 /nref=8 /ntot=150 /MaxReadThrough="2.00954" /MaxDrop="5.13029" /score="17.5501827" /energy="-13.8" /TU="NA" /idTUdmin="U294" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(419041..419919) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388267.2" /db_xref="EnsemblGenomes-Gn:BSU03850" /db_xref="EnsemblGenomes-Tr:CAB12193" /db_xref="GOA:P94423" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12039" /db_xref="UniProtKB/Swiss-Prot:P94423" /translation="MLDKKTDILLAARKLFSEKDFTSVSMQAIAEECKMSKASIYKLF QSKEDLLLELLSFNQKQMVAAASRLQENTALTPEERLTQKVKMELEGFRRNQQFFNML TYGNPKLHNDRVKQHIHQTRSTIICWHRDSLIQAYGETILPFVWDLVIILHGMMREFL MLIKIEEKPLELDPIAEFIISTLNQIIKNRETRQSLLPPEAIELYIHSASSYKPKDKS VLLSESLKELHKGISSLSAADYDVDELTSAAAMLEEEAKKEEPRAFLLKSLIGYLEQT GVLTQPVSMLKTLLIT*" /label="ycnC CDS" gene complement(419041..419919) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /label="ycnC gene" S_feature complement(419920..419986) /Source="Nicolas_S_feature" /locus_tag="new_438353_438419_c" /HighExp="dia15, H2O2, Diami, Paraq, Oxctl, Cold, G180, Salt, BMM, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S131" promotor_-10 complement(419985..420004) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(419994) /Source="Nicolas_upshifts" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(420019..420025) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(420083..420832) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /EC_number="1.5.1.39" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16229462, 9836433, 20862523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16229462, 9836433, 20862523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-FMN oxidoreductase (nitroreductase)" /protein_id="NP_388268.1" /db_xref="EnsemblGenomes-Gn:BSU03860" /db_xref="EnsemblGenomes-Tr:CAB12194" /db_xref="GOA:P94424" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:1ZCH" /db_xref="SubtiList:BG12040" /db_xref="UniProtKB/Swiss-Prot:P94424" /translation="MNEVIKSLTDHRSIRSYTDEPVAQEQLDQIIEAVQSAPSSINGQ QVTVITVQDKERKKKISELAGGQPWIDQAPVFLLFCADFNRAKIALEDLHDFKMEITN GLESVLVGAVDAGIALGTATAAAESLGLGTVPIGAVRGNPQELIELLELPKYVFPLSG LVIGHPADRSAKKPRLPQEAVNHQETYLNQDELTSHIQAYDEQMSEYMNKRTNGKETR NWSQSIASYYERLYYPHIREMLEKQGFKVEK*" /label="nfrAB CDS" gene complement(420083..420832) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /label="nfrAB gene" downshifts complement(420096) /Source="Nicolas_upshifts" /id="D171" /incds=0 /nref=136 /ntot=243 /MaxReadThrough="2.08639" /MaxDrop="5.10745" /score="11.1864402" /energy="-18.6" /TU="NA" /idTUdmin="U296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(420849..421136) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17274596, 21454635; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AI-2 degrading enzyme" /protein_id="NP_388269.1" /db_xref="EnsemblGenomes-Gn:BSU03870" /db_xref="EnsemblGenomes-Tr:CAB12195" /db_xref="GOA:P94425" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12041" /db_xref="UniProtKB/Swiss-Prot:P94425" /translation="MIVLQAYIKVKPEKREEFLSEAQSLVQHSRAEEGNAQYDLFEKV GEENTFVMLEKWKDEAAMKFHNETAHFQGFVAKGKELLSAPLDVVRTELSE*" /label="ycnE CDS" gene complement(420849..421136) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /label="ycnE gene" promotor_-35 421102..421109 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421123..421142 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421142 /Source="Nicolas_upshifts" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(421180..421199) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421196) /Source="Nicolas_upshifts" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(421213..421220) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 421241..421248 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 421253 /Source="Nicolas_upshifts" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 421259..421278 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 421276..421590 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388270.1" /db_xref="EnsemblGenomes-Gn:BSU03880" /db_xref="EnsemblGenomes-Tr:CAB12196" /db_xref="GOA:O31480" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12781" /db_xref="UniProtKB/Swiss-Prot:O31480" /translation="MNIPNHPETETLQLTKVLHALSDPLRLELVKQLAEAKEKTCSTC ADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDLEKAFPGLLEAVLNVDQD RW*" /label="yczG CDS" gene 421276..421590 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /label="yczG gene" downshifts 421582 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(421592..423031) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" /label="gabR CDS" gene complement(421592..423031) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /label="gabR gene" promotor_-10 complement(421916..421927) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421922) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(421941..421947) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(423074..423093) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 423075..423082 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(423081) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 423096..423115 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 423100 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(423104..423111) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 423138..424448 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" /label="gabT CDS" gene 423138..424448 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /label="gabT gene" promotor_-35 424326..424332 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424346..424364 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424354 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 424450..424457 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424472..424491 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424481 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" CDS 424517..425905 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" /label="gabD CDS" gene 424517..425905 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /label="gabD gene" downshifts 425913 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 425963..425969 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 425983..425994 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 425984 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="upshifts" CDS 426028..426891 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" /label="glcU CDS" gene 426028..426891 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /label="glcU gene" CDS 426911..427696 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" /label="gdh CDS" gene 426911..427696 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /label="gdh gene" misc_feature 427016..427035 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 427016 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 427104 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" /label="downshifts" downshifts 427698 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" /label="downshifts" CDS complement(427741..428355) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" /label="cutI CDS" gene complement(427741..428355) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /label="cutI gene" downshifts complement(427752) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(428368..429993) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" /label="cutJ CDS" gene complement(428368..429993) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /label="cutJ gene" CDS complement(430028..430600) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" /label="cutR CDS" gene complement(430028..430600) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /label="cutR gene" promotor_-10 complement(430622..430641) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(430637) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(430655..430662) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 430722..430741 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 430734 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="upshifts" CDS 430765..431118 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" /label="ycnL CDS" gene 430765..431118 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /label="ycnL gene" downshifts 431089 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 431182..431189 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431203..431222 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431208 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" S_feature 431218..431290 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 431291..432727 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" /label="mtlA CDS" gene 431291..432727 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /label="mtlA gene" CDS 432752..433183 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" /label="mtlF CDS" gene 432752..433183 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /label="mtlF gene" CDS 433185..434306 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" /label="mtlD CDS" gene 433185..434306 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /label="mtlD gene" downshifts 434289 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-35 434335..434338 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 434354..434373 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 434356 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="upshifts" CDS 434397..435461 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" /label="ycsA CDS" gene 434397..435461 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /label="ycsA gene" promotor_-35 434631..434639 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 434653..434672 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 434663 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 435455 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 435528..435535 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 435548..435567 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 435561 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 435596..436159 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" /label="sipU CDS" gene 435596..436159 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /label="sipU gene" S_feature 436160..436884 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(436219..436827) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" /label="yczH CDS" gene complement(436219..436827) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /label="yczH gene" misc_feature complement(436845..436864) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 436861..436867 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(436868) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 436880..436899 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 436886 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 436913..437305 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" /label="ycsD CDS" gene 436913..437305 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /label="ycsD gene" downshifts 437282 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(437338..437502) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" /label="yczO CDS" gene complement(437338..437502) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /label="yczO gene" downshifts complement(437358) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(437512..437530) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(437534) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(437545..437551) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 437564..437571 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 437585..437604 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 437588 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="upshifts" CDS 437635..438384 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" /label="ribZ CDS" gene 437635..438384 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /label="ribZ gene" downshifts 438361 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(438437) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" promotor_-35 438467..438473 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 438487..438506 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 438493..438589 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 438493 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 438590..439363 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" /label="pxpA CDS" gene 438590..439363 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /label="pxpA gene" CDS 439378..440592 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" /label="pxpG CDS" gene 439378..440592 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /label="pxpG gene" CDS 440616..441389 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" /label="pxpI CDS" gene 440616..441389 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /label="pxpI gene" CDS 441434..442156 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" /label="pxpB CDS" gene 441434..442156 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /label="pxpB gene" CDS 442159..443166 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" /label="pxpC CDS" gene 442159..443166 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /label="pxpC gene" downshifts 442652 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" /label="downshifts" promotor_no_box 442746..442846 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 442806 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 443182..443934 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" /label="pxpR CDS" gene 443182..443934 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /label="pxpR gene" promotor_-35 443932..443941 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 443955..443974 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 443965 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 443998..444639 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" /label="lipC CDS" gene 443998..444639 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /label="lipC gene" downshifts 444625 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(444637..445062) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(444682) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 444715..444721 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 444735..444754 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 444736 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="upshifts" CDS 444812..445057 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" /label="yczI CDS" gene 444812..445057 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /label="yczI gene" S_feature 445058..445468 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(445063..445350) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" /label="yczJ CDS" gene complement(445063..445350) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /label="yczJ gene" misc_feature complement(445371..445390) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(445387) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 445444..445448 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 445465..445484 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 445470 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 445501..447507 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" /label="pbpC CDS" gene 445501..447507 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /label="pbpC gene" S_feature 447508..447608 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 447609..448511 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" /label="ycsN CDS" gene 447609..448511 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /label="ycsN gene" downshifts 448491 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 448584..448591 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 448605..448624 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 448609..448696 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 448609 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 448697..450781 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" /label="mtlR CDS" gene 448697..450781 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /label="mtlR gene" downshifts 450768 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 450810..450816 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450830..450848 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 450842 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="upshifts" S_feature 450853..450934 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 450896..450903 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450917..450936 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 450936 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="upshifts" CDS 450993..452504 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" /label="ydaB CDS" gene 450993..452504 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /label="ydaB gene" downshifts 452488 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" /label="downshifts" CDS complement(452524..453069) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" /label="ydaC CDS" gene complement(452524..453069) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /label="ydaC gene" downshifts complement(452557) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(453136..453154) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(453150) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(453169..453175) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 453211..453217 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 453229 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="upshifts" promotor_-10 453232..453250 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 453276..454136 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" /label="ydaD CDS" gene 453276..454136 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /label="ydaD gene" CDS 454152..454655 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" /label="lyxE CDS" gene 454152..454655 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /label="lyxE gene" downshifts 454636 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" /label="downshifts" promotor_-35 454684..454691 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 454705..454724 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 454707 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 454741..455292 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" /label="ydaF CDS" gene 454741..455292 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /label="ydaF gene" promotor_-35 455307..455313 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455328..455346 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 455341 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 455370..455792 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" /label="ydaG CDS" gene 455370..455792 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /label="ydaG gene" promotor_-35 455797..455805 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455816..455835 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 455835..456201 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 455835 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(455861..455961) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(455896..456164) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" /label="bsrC RNA" gene complement(455896..456164) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /label="bsrC gene" upshifts complement(455901) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 456158 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 456238..456247 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 456260..456275 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 456265 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 456298..457107 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" /label="amj CDS" gene 456298..457107 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /label="amj gene" downshifts 457088 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" /label="downshifts" CDS complement(457151..457441) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" /label="ydzA CDS" gene complement(457151..457441) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /label="ydzA gene" downshifts complement(457155) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(457469..457488) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 457469..457487 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 457475 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(457485) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 457563..457570 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 457584..457603 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 457588 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 457626..458060 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" /label="lrpC CDS" gene 457626..458060 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /label="lrpC gene" promotor_-35 458057..458060 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 458069 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 458077..458096 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 458125..460308 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" /label="topB CDS" gene 458125..460308 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /label="topB gene" downshifts 460291 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 460357..460363 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 460378..460396 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 460379..460510 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 460379 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="upshifts" CDS 460511..461599 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" /label="epsJ CDS" gene 460511..461599 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /label="epsJ gene" CDS 461580..462431 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" /label="epsK CDS" gene 461580..462431 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /label="epsK gene" CDS 462442..464151 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" /label="ydaL CDS" gene 462442..464151 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /label="ydaL gene" CDS 464144..465406 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" /label="ydaM CDS" gene 464144..465406 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /label="ydaM gene" CDS 465412..467523 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" /label="ydaN CDS" gene 465412..467523 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /label="ydaN gene" downshifts 467507 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" /label="downshifts" promotor_-35 467620..467627 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 467642..467661 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 467649 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 467659..467802 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" /label="swaO RNA" gene 467659..467802 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /label="swaO gene" downshifts 467800 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" /label="downshifts" S_feature 467845..467998 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 467999..469822 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" /label="kimA CDS" gene 467999..469822 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /label="kimA gene" downshifts 469814 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" /label="downshifts" CDS 469881..470330 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" /label="nudT CDS" gene 469881..470330 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /label="nudT gene" promotor_-35 470343..470349 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 470364..470382 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 470365 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="upshifts" CDS 470397..472121 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" /label="poxB CDS" gene 470397..472121 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /label="poxB gene" S_feature complement(471233..472092) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(472094..472205) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 472105 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(472113..472316) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" /label="hypothetical protein CDS" gene complement(472113..472316) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /label="gene" downshifts complement(472137) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(472165..472265) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 472174..472179 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 472196..472214 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472205) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature 472206..472421 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 472206 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(472272..472343) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(472315) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(472344..472610) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" /label="ydzK CDS" gene complement(472344..472610) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /label="ydzK gene" promotor_-10 complement(472626..472645) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472644) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(472657..472664) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(472714..473991) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" /label="mntH CDS" gene complement(472714..473991) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /label="mntH gene" downshifts complement(472733) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(474053..474072) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474065) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(474067..474144) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(474085..474092) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(474128..474147) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474144) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(474161..474170) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(474221..474478) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" /label="ydaS CDS" gene complement(474221..474478) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /label="ydaS gene" downshifts complement(474229) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" downshifts complement(474295) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS complement(474556..475008) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" /label="ydaT CDS" gene complement(474556..475008) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /label="ydaT gene" promotor_-10 complement(475027..475045) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(475044) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(475059..475065) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 475077 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 475085..475104 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 475126..475944 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" /label="ydbA CDS" gene 475126..475944 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /label="ydbA gene" downshifts 475935 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 476012..476018 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476032..476050 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476040 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="upshifts" CDS 476073..476444 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" /label="gsiB CDS" gene 476073..476444 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /label="gsiB gene" downshifts complement(476077) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 476461 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" upshifts complement(476495) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(476498..476501) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 476523..476530 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476542..476561 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476549 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="upshifts" CDS 476576..476917 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" /label="ydbB CDS" gene 476576..476917 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /label="ydbB gene" CDS 476911..477270 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" /label="ydbC CDS" gene 476911..477270 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /label="ydbC gene" S_feature complement(476973..477266) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 477211 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 477255 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(477307..478128) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" /label="ydbD CDS" gene complement(477307..478128) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /label="ydbD gene" downshifts complement(477311) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(478150..478168) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478171) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(478182..478188) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(478213..479265) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" /label="dctB CDS" gene complement(478213..479265) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /label="dctB gene" promotor_-35 478525..478532 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 478547..479334 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 478547..478566 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478548 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(479278..479297) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(479283) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(479311..479318) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 479335..480942 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" /label="dctS CDS" gene 479335..480942 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /label="dctS gene" CDS 480932..481612 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" /label="dctR CDS" gene 480932..481612 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /label="dctR gene" S_feature 481613..481687 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 481654..481661 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 481676..481693 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 481689 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="upshifts" CDS 481733..482998 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" /label="dctP CDS" gene 481733..482998 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /label="dctP gene" downshifts 482991 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(483045) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" /label="downshifts" misc_feature 483082..483099 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 483084 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 483146..484198 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" /label="ydbI CDS" gene 483146..484198 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /label="ydbI gene" S_feature 484199..484442 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 484399 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" CDS 484475..485401 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" /label="ydbJ CDS" gene 484475..485401 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /label="ydbJ gene" CDS 485421..486161 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" /label="ydbK CDS" gene 485421..486161 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /label="ydbK gene" misc_feature 486220..486239 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 486225 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 486256..486591 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" /label="ydbL CDS" gene 486256..486591 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /label="ydbL gene" downshifts 486566 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" /label="downshifts" S_feature 486611..486680 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 486646..486653 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 486667..486686 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 486681 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 486719..487864 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" /label="ydbM CDS" gene 486719..487864 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /label="ydbM gene" downshifts 487846 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(487889..488068) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" /label="fbpB CDS" gene complement(487889..488068) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /label="fbpB gene" downshifts complement(487907) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(488022..488186) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" /label="fbpA CDS" gene complement(488022..488186) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /label="fbpA gene" S_feature complement(488069..488237) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(488229..488248) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(488239) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(488263..488270) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 488378..488383 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488399..488417 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488403 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="upshifts" CDS 488433..489305 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" /label="ydbO CDS" gene 488433..489305 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /label="ydbO gene" promotor_-35 488669..488678 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488691..488706 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488694 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(489250..489319) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(489293) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 489306..489655 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(489320..489640) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" /label="ydbP CDS" gene complement(489320..489640) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /label="ydbP gene" promotor_-35 489636..489640 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 489649..489663 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 489657..489814 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 489657 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(489661..489680) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(489676) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(489694..489701) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 489815..490879 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" /label="ddlA CDS" gene 489815..490879 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /label="ddlA gene" downshifts 490867 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS 490951..492324 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" /label="murF CDS" gene 490951..492324 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /label="murF gene" promotor_-35 492355..492361 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492375..492386 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 492385 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 492428..492447 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 492429..492603 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 492429 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 492571..492578 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492593..492612 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 492605..492672 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 492605 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="upshifts" CDS 492724..494208 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" /label="cshA CDS" gene 492724..494208 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /label="cshA gene" downshifts 494201 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" S_feature 494321..494380 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 494321..494330 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 494323 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 494342..494357 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 494381..494860 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " /label="ydbS CDS" gene 494381..494860 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /label="ydbS gene" CDS 494850..496331 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" /label="ydbT CDS" gene 494850..496331 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /label="ydbT gene" downshifts 496301 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature 496346..496673 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(496355) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" /label="downshifts" CDS complement(496583..497182) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" /label="ydcA CDS" gene complement(496583..497182) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /label="ydcA gene" promotor_-35 496643..496648 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 496661..496680 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 496675..497276 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 496675 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(497206..497225) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(497217) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="upshifts" CDS 497277..497642 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" /label="acpS CDS" gene 497277..497642 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /label="acpS gene" promotor_-35 497645..497650 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 497666..497807 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 497666..497684 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 497666 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="upshifts" CDS 497808..498824 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" /label="ydcC CDS" gene 497808..498824 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /label="ydcC gene" downshifts 498809 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 498869..498876 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 498890..498909 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 498897 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 498939..500108 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" /label="alrA CDS" gene 498939..500108 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /label="alrA gene" promotor_-35 500037..500042 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500057..500075 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500063 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 500138..500141 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500157..500176 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500158 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 500224..500505 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" /label="ndoAI CDS" gene 500224..500505 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /label="ndoAI gene" CDS 500510..500860 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" /label="ndoA CDS" gene 500510..500860 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /label="ndoA gene" S_feature complement(500650..501126) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(500693) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts 500840 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" /label="downshifts" promotor_-35 500894..500901 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500915..500934 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500923 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 500975..501799 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" /label="rsbRA CDS" gene 500975..501799 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /label="rsbRA gene" promotor_-10 complement(501109..501127) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501126) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(501128..501727) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(501141..501148) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(501716..501734) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501727) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(501729..502317) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(501748..501754) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 501804..502169 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" /label="rsbS CDS" gene 501804..502169 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /label="rsbS gene" CDS 502173..502574 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" /label="rsbT CDS" gene 502173..502574 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /label="rsbT gene" promotor_-10 complement(502315..502334) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(502332) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(502348..502357) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 502586..503593 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" /label="rsbU CDS" gene 502586..503593 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /label="rsbU gene" promotor_-35 503587..503593 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 503608..503626 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 503614 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 503655..503984 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" /label="rsbV CDS" gene 503655..503984 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /label="rsbV gene" CDS 503981..504463 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" /label="rsbW CDS" gene 503981..504463 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /label="rsbW gene" CDS 504429..505217 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" /label="sigB CDS" gene 504429..505217 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /label="sigB gene" CDS 505217..505816 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" /label="rsbX CDS" gene 505217..505816 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /label="rsbX gene" downshifts 505802 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 505860..505866 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 505881..505900 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" Polymorphism join(505889,505891) /Source="geneious" /ID="SNP_BsDelta6_524323_524323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="A -> C" /Codon_Change /Coverage=183 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="BSU_04745_promoter_down_mutation" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 505893 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 505927..506043 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" /label="hypothetical protein CDS" gene 505927..506043 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /label="gene" CDS 506059..506352 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" /label="ydcF CDS" gene 506059..506352 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /label="ydcF gene" promotor_-35 506320..506328 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506340..506359 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 506349..506789 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" /label="ydcG CDS" gene 506349..506789 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /label="ydcG gene" upshifts 506355 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(506588..509643) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 506773..507216 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" /label="ydcH CDS" gene 506773..507216 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /label="ydcH gene" downshifts 507191 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 507247..507248 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 507264..507283 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 507264 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="upshifts" CDS 507310..509469 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" /label="tex CDS" gene 507310..509469 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /label="tex gene" misc_feature 509457..509476 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 509479..509695 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 509479 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="upshifts" CDS complement(509479..509592) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" /label="cmpA CDS" gene complement(509479..509592) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /label="cmpA gene" promotor_-10 complement(509632..509651) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(509649) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(509666..509674) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 509696..510148 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" /label="ydcK CDS" gene 509696..510148 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /label="ydcK gene" promotor_-35 510154..510160 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 510175..510194 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 510183..510270 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 510183 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(510215) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" /label="downshifts" tRNA 510271..510345 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Asn tRNA" gene 510271..510345 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /label="trnS-Asn gene" tRNA 510350..510440 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Ser tRNA" gene 510350..510440 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /label="trnS-Ser gene" tRNA 510470..510541 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Glu tRNA" gene 510470..510541 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /label="trnS-Glu gene" tRNA 510553..510627 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Gln tRNA" gene 510553..510627 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /label="trnS-Gln gene" tRNA 510654..510729 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Lys tRNA" gene 510654..510729 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /label="trnS-Lys gene" tRNA 510741..510822 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu1 tRNA" gene 510741..510822 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /label="trnS-Leu1 gene" downshifts 510887 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA 510903..>510988 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu2 tRNA" gene 510903..>510988 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /modified_by="User" /label="trnS-Leu2 gene" SCAR 510988..510989 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="Delta6_2" S_feature complement(<510989..511295) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S175" downshifts 511008 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" /label="downshifts" downshifts complement(511040) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(511296..512315) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" /label="yddN CDS" gene complement(511296..512315) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /label="yddN gene" promotor_-10 complement(511991..512010) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(512004) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(512025..512032) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 512104..512108 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 512125..512144 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 512129 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="upshifts" S_feature 512130..512574 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 512575..512985 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" /label="lrpA CDS" gene 512575..512985 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /label="lrpA gene" S_feature 512986..513055 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 513012 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" /label="downshifts" CDS complement(513108..513557) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" /label="lrpB CDS" gene complement(513108..513557) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /label="lrpB gene" CDS 513672..514214 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" /label="yddQ CDS" gene 513672..514214 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /label="yddQ gene" promotor_-35 514687..514691 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 514708..514727 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 514717 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="upshifts" CDS 514767..515531 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" /label="yddR CDS" gene 514767..515531 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /label="yddR gene" CDS 515725..517035 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" /label="yddS CDS" gene 515725..517035 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /label="yddS gene" S_feature 517058..517617 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 517618..517794 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" /label="ydzM CDS" gene 517618..517794 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /label="ydzM gene" CDS 517819..518505 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" /label="yddT CDS" gene 517819..518505 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /label="yddT gene" promotor_-35 518847..518851 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 518866..518885 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 518874 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="upshifts" Polymorphism join(518921,518923) /Source="geneious" /ID="SNP_BsDelta6_557866_557865" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)5 -> (T)6" /Codon_Change /Coverage=35 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value="3.2e-123" /Variant_Raw_Frequency=35 /comment="ydzN_translation_signal_variant" /modified_by="User" / /label="Polymorphism_Delta6" CDS 518930..519115 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" /label="ydzN CDS" gene 518930..519115 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /label="ydzN gene" downshifts 519114 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" /label="downshifts" CDS 519465..520058 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" /label="sufLC CDS" gene 519465..520058 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /label="sufLC gene" promotor_-35 520171..520178 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 520192..520211 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 520203..520320 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 520203 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(520238) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" /label="downshifts" CDS 520321..520521 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" /label="cspC CDS" gene 520321..520521 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /label="cspC gene" S_feature complement(520419..521207) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 520424 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 520525 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" /label="downshifts" misc_RNA complement(520589..520667) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sncZ RNA" gene complement(520589..520667) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /label="sncZ gene" CDS complement(521208..521669) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" /label="cdnL CDS" gene complement(521208..521669) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /label="cdnL gene" S_feature 521678..522223 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(521721) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(521728..521747) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(521763..521770) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 522190 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" /label="downshifts" CDS complement(522237..522473) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" /label="ydzE CDS" gene complement(522237..522473) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /label="ydzE gene" CDS complement(522571..523446) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" /label="ydeC CDS" gene complement(522571..523446) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /label="ydeC gene" CDS 523559..524518 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" /label="ydeD CDS" gene 523559..524518 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /label="ydeD gene" upshifts complement(523580) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(523584..523603) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(524671..525543) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" /label="ydeE CDS" gene complement(524671..525543) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /label="ydeE gene" promotor_-10 complement(525636..525641) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(525643..525644) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(525648) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 525717..525723 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 525731 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 525737..525756 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 525770..527158 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" /label="ydeF CDS" gene 525770..527158 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /label="ydeF gene" downshifts 527134 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS 527268..528560 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" /label="ydeG CDS" gene 527268..528560 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /label="ydeG gene" promotor_-35 528569..528575 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 528590..528609 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 528597 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="upshifts" S_feature 528608..528718 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 528719..529165 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" /label="ydeH CDS" gene 528719..529165 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /label="ydeH gene" downshifts 529194 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 529245..529252 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 529267..529286 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 529268 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="upshifts" CDS 529402..529995 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" /label="ydeI CDS" gene 529402..529995 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /label="ydeI gene" downshifts 530038 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(530114) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 530127..530134 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 530148 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 530149..530168 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(530347..531006) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" /label="ydeJ CDS" gene complement(530347..531006) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /label="ydeJ gene" promotor_-10 complement(531055..531074) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(531062) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(531086..531091) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(531428..532291) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" /label="ydeK CDS" gene complement(531428..532291) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /label="ydeK gene" promotor_-35 532334..532340 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 532355..532374 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(532356..532375) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 532370 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(532380) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(532390..532397) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 532446..533837 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" /label="ydeL CDS" gene 532446..533837 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /label="ydeL gene" promotor_-35 533965..533972 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 533983..534002 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 533997 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="upshifts" CDS 534031..534456 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" /label="ydeM CDS" gene 534031..534456 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /label="ydeM gene" S_feature 534457..535711 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(534509..535081) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" /label="ydeN CDS" gene complement(534509..535081) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /label="ydeN gene" downshifts complement(534514) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(535082..535162) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(535163..535492) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" /label="ydzF CDS" gene complement(535163..535492) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /label="ydzF gene" misc_feature complement(535509..535528) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(535526) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="upshifts" misc_feature 535700..535719 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 535713 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="upshifts" CDS 535747..536619 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" /label="ydeO CDS" gene 535747..536619 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /label="ydeO gene" downshifts 536506 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 536704 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(536769..537155) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" /label="ydeP CDS" gene complement(536769..537155) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /label="ydeP gene" downshifts complement(536781) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(537156..537220) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 537208..537215 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(537209..537228) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(537222) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 537229..537248 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 537232 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(537243..537250) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 537266..537859 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" /label="ydeQ CDS" gene 537266..537859 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /label="ydeQ gene" CDS complement(538003..539190) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" /label="ydeR CDS" gene complement(538003..539190) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /label="ydeR gene" promotor_-35 539326..539330 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 539344 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 539345..539364 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 539394..539990 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" /label="ydeS CDS" gene 539394..539990 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /label="ydeS gene" CDS 540104..540289 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" /label="ydzO CDS" gene 540104..540289 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /label="ydzO gene" downshifts 540268 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 540401..540404 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 540411..540597 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 540411 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 540419..540438 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 540598..540933 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" /label="aseR CDS" gene 540598..540933 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /label="aseR gene" CDS 540946..542253 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" /label="arsF CDS" gene 540946..542253 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /label="arsF gene" CDS 542285..542389 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" /label="ydzSn CDS" gene 542285..542389 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo /label="ydzSn gene" CDS 542398..542511 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" /label="ydzSc CDS" gene 542398..542511 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo /label="ydzSc gene" promotor_-35 542697..542705 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 542716..542734 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 542733 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 542751..543536 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" /label="ydfB CDS" gene 542751..543536 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /label="ydfB gene" downshifts 542798 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 543546 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS complement(543593..544513) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" /label="ydfC CDS" gene complement(543593..544513) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /label="ydfC gene" CDS 544646..546094 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" /label="ydfD CDS" gene 544646..546094 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /label="ydfD gene" CDS complement(546212..546835) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" /label="ydfE CDS" gene complement(546212..546835) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /label="ydfE gene" promotor_-10 complement(546859..546878) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 546867..546874 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(546878) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 546889..546908 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 546891 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(546893..546899) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 546925..547605 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" /label="ydfF CDS" gene 546925..547605 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /label="ydfF gene" downshifts 547638 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(547685..548128) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" /label="ydfG CDS" gene complement(547685..548128) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /label="ydfG gene" downshifts complement(547690) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(548151..548170) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(548175) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(548184..548191) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(548214..548393) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" /label="ydzP CDS" gene complement(548214..548393) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /label="ydzP gene" CDS complement(548390..548533) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" /label="ydzQ CDS" gene complement(548390..548533) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /label="ydzQ gene" promotor_-35 548484..548486 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 548502..548521 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 548518 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 548801..550024 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" /label="ydfH CDS" gene 548801..550024 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /label="ydfH gene" CDS 550017..550658 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" /label="ydfI CDS" gene 550017..550658 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /label="ydfI gene" downshifts 550652 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(550685..550704) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(550706) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(550718..550725) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 550766..550771 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 550774..552948 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" /label="ydfJ CDS" gene 550774..552948 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /label="ydfJ gene" upshifts 550784 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 550786..550804 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(551850..551868) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(551850) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(552952..553359) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 552969..552973 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 552983 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 552986..553005 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(552997) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(553360..554262) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" /label="cesA CDS" gene complement(553360..554262) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /label="cesA gene" S_feature complement(554263..554358) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(554338..554357) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(554358) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(554371..554378) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(554464..555153) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" /label="ydfK CDS" gene complement(554464..555153) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /label="ydfK gene" CDS complement(555243..556055) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" /label="ydfL CDS" gene complement(555243..556055) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /label="ydfL gene" promotor_-10 complement(556084..556103) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(556097) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(556119..556126) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(556166..557059) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" /label="mneP CDS" gene complement(556166..557059) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /label="mneP gene" downshifts complement(556186) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(557060..557152) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(557133..557152) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(557150) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(557168..557175) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 557341..557348 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 557363..557382 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 557369 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 557535..558155 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" /label="ydfN CDS" gene 557535..558155 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /label="ydfN gene" promotor_-35 557879..557885 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 557890 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 557899..557917 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 558171..559109 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" /label="ydfO CDS" gene 558171..559109 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /label="ydfO gene" promotor_-35 559097..559100 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 559115..559134 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 559122..559210 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 559122 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 559211..559600 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" /label="ydfP CDS" gene 559211..559600 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /label="ydfP gene" downshifts 559591 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" /label="downshifts" misc_feature 559714..559733 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 559716..559785 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 559716 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 559786..560124 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" /label="ydfQ CDS" gene 559786..560124 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /label="ydfQ gene" downshifts 560112 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560164..560400) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" /label="ydzH CDS" gene complement(560164..560400) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /label="ydzH gene" downshifts complement(560188) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 560212..560218 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 560233..560244 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 560244 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(560401..560562) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(560566..560931) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(560606) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560932..561162) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" /label="ydzR CDS" gene complement(560932..561162) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /label="ydzR gene" downshifts 561146 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(561183..561202) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(561200) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(561202..561285) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(561216..561225) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(561286..561963) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" /label="ydfR CDS" gene complement(561286..561963) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /label="ydfR gene" promotor_-10 complement(561934..561945) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(561948) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(561960..561966) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(561964..562797) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 561979..561984 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 561999..562010 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 562004 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="upshifts" CDS 562076..562783 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" /label="ydfS CDS" gene 562076..562783 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /label="ydfS gene" CDS complement(562798..563229) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" /label="cotP CDS" gene complement(562798..563229) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /label="cotP gene" CDS complement(563242..563484) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" /label="ydgA CDS" gene complement(563242..563484) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /label="ydgA gene" CDS complement(563498..563770) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" /label="ydgB CDS" gene complement(563498..563770) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /label="ydgB gene" promotor_-10 complement(563792..563811) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(563796) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(563825..563834) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 563989..563996 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 564012..564031 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 564020 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="upshifts" CDS 564069..564656 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" /label="ydgC CDS" gene 564069..564656 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /label="ydgC gene" CDS 564653..564997 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" /label="ydgD CDS" gene 564653..564997 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /label="ydgD gene" S_feature 564998..565159 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 565160..565633 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" /label="ydgE CDS" gene 565160..565633 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /label="ydgE gene" S_feature 565634..566326 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(565776) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(565793..567436) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" /label="vmlR CDS" gene complement(565793..567436) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /label="vmlR gene" S_feature complement(567471..567668) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 567485..567487 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 567504..567522 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 567508 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(567514) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 567634 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(567660..567679) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(567672) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(567692..567699) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(567755) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(567756..569132) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" /label="ydgF CDS" gene complement(567756..569132) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /label="ydgF gene" misc_feature complement(569182..569201) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(569197) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="upshifts" Polymorphism join(569271,569273) /Source="geneious" /ID="SNP_BsDelta6_608215_608214" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)5 -> (A)6" /Codon_Change /Coverage=41 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="8.2e-115" /Variant_Raw_Frequency=39 /comment="dinB_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" terminator 569272..569305 /created_by="User" /comment="dinB_terminator_improvement" /modified_by="User" /label="Delta6_dinB_Terminator" CDS complement(569304..569822) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" /label="dinB CDS" gene complement(569304..569822) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /label="dinB gene" downshifts complement(569318) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(569848..569867) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(569867) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(569883..569886) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 569904..569911 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 569926..569945 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 569944 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="upshifts" CDS 569991..570449 /gene="ydgG" /locus_tag="BSU_05640" /old_locus_tag="BSU05640" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388445.1" /db_xref="EnsemblGenomes-Gn:BSU05640" /db_xref="EnsemblGenomes-Tr:CAB12371" /db_xref="GOA:P96705" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12174" /db_xref="UniProtKB/Swiss-Prot:P96705" /translation="MNEQKLCQAINLFVEVLLEGTEFVHREINQDVFKHISREQADLL KILKVKGPTSPGSLAMYQNVHKSAISNRLKKLLEKGLVQWDDCPEKSDRRSKLINITP SGEHILEELDSAIFNALKPLIDDIDEEHLHSIIEIFTILKSKFKGGDSAE*" /label="ydgG CDS" gene 569991..570449 /gene="ydgG" /locus_tag="BSU_05640" /old_locus_tag="BSU05640" /label="ydgG gene" CDS 570446..573103 /gene="ydgH" /locus_tag="BSU_05650" /old_locus_tag="BSU05650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388446.1" /db_xref="EnsemblGenomes-Gn:BSU05650" /db_xref="EnsemblGenomes-Tr:CAB12372" /db_xref="GOA:P96706" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12175" /db_xref="UniProtKB/Swiss-Prot:P96706" /translation="MRAIIKFKWAIAAIVLALTVVLSLFSPNLTELANQKGQAQLPAD AVSERANAILKQAGEDNNSISVVFTLDNAIKKETENQLRIIIDKIKKIDGVEEVTSPL SAEKEVKDQLMSKDKKTVLMPVTITGSDKKAEKIADEIYQIVPDDLTAYITGASLINQ DFAHSSEEGLKKTEVITVCLIIGLLLIVFRSVVTPFIPIVVVGFSYLISQSILGILVY NVDFPISTFTQTFLVAILFGIGTDYCILLLTRFREELANGHDKKEAALIAYRTGGKTL FISGFAVLIGFSALGFAKFAIFQSAVGVAVGVGILMIILYTLLPLFMVTLGEKLFWPS KKVLSHSDNKLWAFLGRHSVARPFLFIVITVVITLPFILTYDDQISFDSTAEISSDYK SIKALEAIKDGFGEGKAFPINVVVKGDKDLTTADTIPYLGNISKAIEKVDHVDSVMTI TQPTGKKIKDLYIDNQLGSVSDGLDKTVKGIADVQSGLTDIENGLNQMAGQTGSASNG GSGGSLGDAADGLGKINQQLQLVSKQISQTGNTAQTVQQLTAISGQLGQIQTGLEQAN QQLSGQQAQAGTLTESLKKLSEGVKSANEGLTKVSDGITASSDILEDMSKSPTVRDTG IFIPDQVMKDKDFKKSIDQYSFADGKGVQLSVVLDSNPYSEQAITTINQIKKAVANEV DGTPLENAQIVYGGVTSMNADLKELSTTDFSRTMVIMIIGLFIVLTILFRSMIMPIYM IASLLLTYYTSISITELIFVNGLGNAGVSWAVPFFSFVILIALGVDYSIFLLDRFKEE VHLGIEQGVVRSMSKMGSVIITAAIILAGTFAAMMPSGVNTLMQVASVIIIGLLLYGL VILPLFIPAIIATFGEGNWWPFGRKKGKE*" /label="ydgH CDS" gene 570446..573103 /gene="ydgH" /locus_tag="BSU_05650" /old_locus_tag="BSU05650" /label="ydgH gene" downshifts 573224 /Source="Nicolas_upshifts" /id="D272" /incds=0 /nref=3 /ntot=27 /MaxReadThrough="0.245049999999999" /MaxDrop="4.45167" /score="13.780898" /energy="-13.9" /TU="NA" /idTUdmin="U439" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(573249..573878) /gene="ydgI" /locus_tag="BSU_05660" /old_locus_tag="BSU05660" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26415543; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase of unidentified specificity (reduces 5-(aziridin-1-yl)-2,4-dinitrobenzamide prodrug)" /protein_id="NP_388447.1" /db_xref="EnsemblGenomes-Gn:BSU05660" /db_xref="EnsemblGenomes-Tr:CAB12385" /db_xref="GOA:P96707" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12176" /db_xref="UniProtKB/Swiss-Prot:P96707" /translation="MIKTNDFMEIMKGRRSIRNYDPAVKISKEEMTEILEEATTAPSS VNAQPWRFLVIDSPEGKEKLAPLASFNQTQVTTSSAVIAVFADMNNADYLEEIYSKAV ELGYMPQEVKDRQIAALTAHFEKLPAQVNRETILIDGGLVSMQLMLTARAHGYDTNPI GGYDKENIAETFGLDKERYVPVMLLSIGKAADEGYASYRLPIDTIAEWK*" /label="ydgI CDS" gene complement(573249..573878) /gene="ydgI" /locus_tag="BSU_05660" /old_locus_tag="BSU05660" /label="ydgI gene" downshifts complement(573253) /Source="Nicolas_upshifts" /id="D273" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="2.66406" /MaxDrop="6.06581" /score="21.7451043" /energy="-16.6" /TU="NA" /idTUdmin="U440" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(573894..574388) /gene="ydgJ" /locus_tag="BSU_05670" /old_locus_tag="BSU05670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388448.1" /db_xref="EnsemblGenomes-Gn:BSU05670" /db_xref="EnsemblGenomes-Tr:CAB12386" /db_xref="GOA:P96708" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12177" /db_xref="UniProtKB/Swiss-Prot:P96708" /translation="MTCQSLIYQLIVLTGKKGWVLASFCSEEAEILYQLQGVNKVIGV KFEACTGISQSRLELLTLLYHADEISQSDLQKKVNIDSAAVTRHLKQLESKGMVSRRR KPEDNRITLVRLTDQGRERIESSKKEKERFMKEMLANVSAEERRLLIDVLARMRNNIN NIEA*" /label="ydgJ CDS" gene complement(573894..574388) /gene="ydgJ" /locus_tag="BSU_05670" /old_locus_tag="BSU05670" /label="ydgJ gene" promotor_-10 complement(574380..574399) /Source="Nicolas_upshift_promotors" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(574395) /Source="Nicolas_upshifts" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(574415..574420) /Source="Nicolas_upshift_promotors" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 574586..574588 /Source="Nicolas_upshift_promotors" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 574604..574623 /Source="Nicolas_upshift_promotors" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 574610..574698 /Source="Nicolas_S_feature" /locus_tag="new_613552_613640" /HighExp="H2O2, G180, G135, Diami, Paraq, Oxctl, G150, LBGexp, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S199" upshifts 574610 /Source="Nicolas_upshifts" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="upshifts" CDS 574699..575907 /gene="ydgK" /locus_tag="BSU_05680" /old_locus_tag="BSU05680" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388449.1" /db_xref="EnsemblGenomes-Gn:BSU05680" /db_xref="EnsemblGenomes-Tr:CAB12387" /db_xref="GOA:P96709" /db_xref="InterPro:IPR004812" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12178" /db_xref="UniProtKB/Swiss-Prot:P96709" /translation="MLHNPTGKERLALAFLLGMLAILGPLNIDMYLPSFPEIAKDLSA SASLVQLSLTACLVGLTIGQLIVGPVSDAQGRRKPLLICIFLFALSSLFCALSPNITT LVAARFLQGFTASAGLVLSRAIVRDVFTGRELSKFFSLLMVITAVAPMVAPMTGGAIL LLPFATWHTIFHVLMIIGFLLVLLIALRLKETLPLEKRIPSSIGTSVKTMGSLLKDRS FMGYALTVGFIHGGSFAYVSGTPFVYQDIYGVSPQVFSILFGINGLAIISGSFIIGRF GGIIHEKSLLRIAVITAMIATAVLLTMTMIHGPLATLVISIFIYMITIGMVLTSTFTL AMEKQGHRAGSASALLGMLPLLLGSIVSPLVGINETTAVPMGAIMFVTAVIGSLAFFG LTKERVGQNS*" /label="ydgK CDS" gene 574699..575907 /gene="ydgK" /locus_tag="BSU_05680" /old_locus_tag="BSU05680" /label="ydgK gene" downshifts 575886 /Source="Nicolas_upshifts" /id="D274" /incds=0 /nref=23 /ntot=112 /MaxReadThrough="0.507390000000001" /MaxDrop="3.27202" /score="25.806679" /energy="-7.5" /TU="NA" /idTUdmin="U441" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(575943..576680) /gene="ydhB" /locus_tag="BSU_05690" /old_locus_tag="BSU05690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388450.2" /db_xref="EnsemblGenomes-Gn:BSU05690" /db_xref="EnsemblGenomes-Tr:CAB12388" /db_xref="GOA:O05493" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG12179" /db_xref="UniProtKB/Swiss-Prot:O05493" /translation="MLIILVMFLLGIILGFIGAGGAGFVIALLTLLFHIPIHTALGTS LAGMAFTSLSGAYSHYREGNIQMKIGLIVGGFAAVGSFFGAKLTSFIPADLLHYLTAG MLFLSAILILIRLFILKEKAQVNQSTLSTYTRAVILGIAAGVLSGTFGIGSAPFIQIG LMIMLNLSIRHSVGTTMLVIIPLAVGGGIGYITEGFVDYVLLVKVLVGTMCGAYVGAK FTNLMPKVVLKSAIFLTPAIAGLLLLF*" /label="ydhB CDS" gene complement(575943..576680) /gene="ydhB" /locus_tag="BSU_05690" /old_locus_tag="BSU05690" /label="ydhB gene" S_feature complement(576681..576819) /Source="Nicolas_S_feature" /locus_tag="new_615623_615761_c" /HighExp="T0.30H, T1.30H, T1.0H, T-0.40H, T2.0H, T0.0H, LBGstat, T2.30H, T-1.10H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.108111" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S200" promotor_-10 complement(576807..576826) /Source="Nicolas_upshift_promotors" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(576819) /Source="Nicolas_upshifts" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(576840..576847) /Source="Nicolas_upshift_promotors" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 576851..576858 /Source="Nicolas_upshift_promotors" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 576872..576891 /Source="Nicolas_upshift_promotors" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 576876 /Source="Nicolas_upshifts" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="upshifts" CDS 576929..577603 /gene="ydhC" /locus_tag="BSU_05700" /old_locus_tag="BSU05700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388451.1" /db_xref="EnsemblGenomes-Gn:BSU05700" /db_xref="EnsemblGenomes-Tr:CAB12389" /db_xref="GOA:O05494" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12180" /db_xref="UniProtKB/Swiss-Prot:O05494" /translation="MDDFKLDKPTPYYLQFYNQLKKMIFNGTFKPGERINETQLAKSF GVSRSPIREAMRLLEKDGLLKADDRNGFSITSLTAKDVDEIYKIRIPLEQLAVELVID EADEEELTILEKQLEETEKAIHNGTEDTEIIRLNQKFHELLVDFSHNRHLKNLLEHVN DLIHFCRILNYTGDHRAETILREHRRIFEEVKKKNKEAAKQHVLAHFNHDCEHLKHVL EEGKEN*" /label="ydhC CDS" gene 576929..577603 /gene="ydhC" /locus_tag="BSU_05700" /old_locus_tag="BSU05700" /label="ydhC gene" promotor_-35 577662..577667 /Source="Nicolas_upshift_promotors" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 577683..577701 /Source="Nicolas_upshift_promotors" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 577689 /Source="Nicolas_upshifts" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="upshifts" CDS 577730..578992 /gene="spoL" /locus_tag="BSU_05710" /old_locus_tag="BSU05710" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11011148, 12177332; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore cortex lytic enzyme" /protein_id="NP_388452.2" /db_xref="EnsemblGenomes-Gn:BSU05710" /db_xref="EnsemblGenomes-Tr:CAB12390" /db_xref="GOA:O05495" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:3CZ8" /db_xref="SubtiList:BG12181" /db_xref="UniProtKB/Swiss-Prot:O05495" /translation="MFIHIVGPGDSLFSIGRRYGASVDQIRGVNGLDETNIVPGQALL IPLYVYTVQPRDTLTAIAAKAFVPLERLRAANPGISPNALQAGAKITIPSISNYIAGT LSFYVLRNPDLDRELINDYAPYSSSISIFEYHIAPNGDIANQLNDAAAIETTWQRRVT PLATITNLTSGGFSTEIVHQVLNNPTARTNLVNNIYDLVSTRGYGGVTIDFEQVSAAD RDLFTGFLRQLRDRLQAGGYVLTIAVPAKTSDNIPWLRGYDYGGIGAVVNYMFIMAYD WHHAGSEPGPVAPITEIRRTIEFTIAQVPSRKIIIGVPLYGYDWIIPYQPGTVASAIS NQNAIERAMRYQAPIQYSAEYQSPFFRYSDQQGRTHEVWFEDVRSMSRKMQIVREYRL QAIGAWQLTLGFTPGPWLLRKFFTIRKV*" /label="spoL CDS" gene 577730..578992 /gene="spoL" /locus_tag="BSU_05710" /old_locus_tag="BSU05710" /label="spoL gene" downshifts 578966 /Source="Nicolas_upshifts" /id="D275" /incds=0 /nref=33 /ntot=81 /MaxReadThrough="2.3134" /MaxDrop="5.20337" /score="15.7593331" /energy="-7.1" /TU="NA" /idTUdmin="U444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 579064..579071 /Source="Nicolas_upshift_promotors" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 579085..579104 /Source="Nicolas_upshift_promotors" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 579089 /Source="Nicolas_upshifts" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="upshifts" CDS 579153..580340 /gene="ydhE" /locus_tag="BSU_05720" /old_locus_tag="BSU05720" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388453.2" /db_xref="EnsemblGenomes-Gn:BSU05720" /db_xref="EnsemblGenomes-Tr:CAB12391" /db_xref="GOA:O05496" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG12182" /db_xref="UniProtKB/Swiss-Prot:O05496" /translation="MKTVLILNFPAEGHVNPTLGITKAFSDKGYDVHYISTEKYKKRL EAAGATVHLHRDLLRTTPIHVGSPNGILDFVKIHIKTSLDILQIVKDLSKSIQFDFVY YDKFGAGELVRDYLDIPGVSSSASFLFGEEHLKILPLHPESGAPLELDQECEDLLAKM KETYGVAPKNLVQFMNNKGELNVVYTSRYFQPESDRFGDECLFIGPSFPKRAEKTDFP IEQLKDEKVIYISMGTVLDHTEDFFNLCIDAFSGFNGKVVIAAGEKADLTKLKQAPEN FIIAPYVPQLEVLEQSDVFITHGGMNSVNEGIHFSVPLVVMPHDKDQPMVAQRLSELH AGYVISKDEVNAQILKQAVDEVLRNDQYTAGIKKINQSFKECMDMEEVMERIDELIRQ KNK*" /label="ydhE CDS" gene 579153..580340 /gene="ydhE" /locus_tag="BSU_05720" /old_locus_tag="BSU05720" /label="ydhE gene" downshifts 580352 /Source="Nicolas_upshifts" /id="D276" /incds=0 /nref=17 /ntot=224 /MaxReadThrough="1.77672" /MaxDrop="5.25325" /score="-6.36206618" /energy="-12.6" /TU="NA" /idTUdmin="U445" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(580379..581089) /gene="ydhF" /locus_tag="BSU_05730" /old_locus_tag="BSU05730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913081, 11557812; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative phosphate-starvation lipoprotein" /protein_id="NP_388454.1" /db_xref="EnsemblGenomes-Gn:BSU05730" /db_xref="EnsemblGenomes-Tr:CAB12392" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12183" /db_xref="UniProtKB/Swiss-Prot:O05497" /translation="MRRILSILVFAIMLAGCSSNASTEKQHAGGEKTVKAEPQSTSSQ KDSTDDYQPNSQVTDDRTLHKVGQTFSDDKGKAVLKDIKQVNKTYKIGDVELTVKEMK LIHLRPDYSMIDYFHELTHDEEFDFVKVFVDIKNTSTKKVNVAPIALMKTNTGETFDW NKDIYLEELNGELEGGAEKSGNLGFIVNASSGHAHDKAADAEKKTKEIKWIEITTSDV FDHNHKKISDAQKIKIKF*" /label="ydhF CDS" gene complement(580379..581089) /gene="ydhF" /locus_tag="BSU_05730" /old_locus_tag="BSU05730" /label="ydhF gene" downshifts complement(580405) /Source="Nicolas_upshifts" /id="D277" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="4.05808" /MaxDrop="4.7318" /score="13.7192471" /energy="-12.6" /TU="NA" /idTUdmin="U446" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(581155..582543) /gene="phoB" /locus_tag="BSU_05740" /old_locus_tag="BSU05740" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9335276, 10913081, 16030210, 16491025, 26382712, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9335276, 10913081, 16030210, 16491025, 26382712, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase III (promiscuous, heptaprenylglyceryl phosphate is a substrate)" /protein_id="NP_388455.2" /db_xref="EnsemblGenomes-Gn:BSU05740" /db_xref="EnsemblGenomes-Tr:CAB12393" /db_xref="GOA:P19405" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10697" /db_xref="UniProtKB/Swiss-Prot:P19405" /translation="MKKFPKKLLPIAVLSSIAFSSLASGSVPEASAQEKKKGNQDEIK NVIVLIGDGMGVSYTSAYRYLKDNKKTKVVEPTAFDQYLVGQQTTYPDDPEQNVTDSA AAATAMSAGIKTYNNAIAVDNDGSEAKTVLEAAKEKGKATGLVATSEITHATPASFGS HDHSRKNMNSIADDYFDEMVNGKHKIDVLLGGGKSNFDRKDRNLIKEFKKAGYSYVDD RKDMLKNKDSQVLGLFADGGLPKKIDRTKDIPSLKDMTNTAIKKLNKDKDGFFLMVEG SQIDWAGHDNDIVGAMSEMEDFEQAYKAAIDFAKKDKHTLVVATADHSTGGYSIGADG IYNWFSEPIKAAKRTPDFMAEKIADGADVEKTLKTYIDQKKLALTKAEIQSVEEAAKS KEVLDIDNAIENIFNKRSHTGWTTGGHTGEDVPVYAYGPSSETFAGQIDNTEIAKNVF KALQYNIKINDK*" /label="phoB CDS" gene complement(581155..582543) /gene="phoB" /locus_tag="BSU_05740" /old_locus_tag="BSU05740" /label="phoB gene" promotor_-10 complement(582600..582617) /Source="Nicolas_upshift_promotors" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582601) /Source="Nicolas_upshifts" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(582603..582671) /Source="Nicolas_S_feature" /locus_tag="new_621545_621613_c" /HighExp="S6, S4, S5, S3, S7, LoTm, S8, T5.0H, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S201" promotor_-35 complement(582624..582631) /Source="Nicolas_upshift_promotors" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(582661..582679) /Source="Nicolas_upshift_promotors" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582679) /Source="Nicolas_upshifts" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(582695..582700) /Source="Nicolas_upshift_promotors" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 582748..582755 /Source="Nicolas_upshift_promotors" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 582769..582788 /Source="Nicolas_upshift_promotors" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 582771..582904 /Source="Nicolas_S_feature" /locus_tag="new_621713_621846" /HighExp="Diami, dia15, H2O2, Paraq, Oxctl, HPh, G180, G135, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S202" upshifts 582771 /Source="Nicolas_upshifts" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="upshifts" CDS 582905..583276 /gene="fra" /locus_tag="BSU_05750" /old_locus_tag="BSU05750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:20087498, 21744456, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20087498, 21744456, 25826316; Product type f: factor" /codon_start=1 /transl_table=11 /product="frataxin; iron/sulfur chaperone" /protein_id="NP_388456.1" /db_xref="EnsemblGenomes-Gn:BSU05750" /db_xref="EnsemblGenomes-Tr:CAB12394" /db_xref="GOA:Q797E6" /db_xref="InterPro:IPR014922" /db_xref="PDB:2OC6" /db_xref="SubtiList:BG12184" /db_xref="UniProtKB/Swiss-Prot:Q797E6" /translation="MDVFSEYLAGIADPFHRERTEEVLTWIKNKYPNLHTEIKWNQPM FTDHGTFIIGFSVSKKHLAVAPEKVTIAHVEDDIVKAGYDYTEQLIRIPWNGPVDYTL LEKMIEFNILDKADCSTFWRK*" /label="fra CDS" gene 582905..583276 /gene="fra" /locus_tag="BSU_05750" /old_locus_tag="BSU05750" /label="fra gene" downshifts 583255 /Source="Nicolas_upshifts" /id="D278" /incds=0 /nref=9 /ntot=150 /MaxReadThrough="2.88587" /MaxDrop="3.59127" /score="28.8500849" /energy="-8.1" /TU="NA" /idTUdmin="U448" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(583350) /Source="Nicolas_upshifts" /id="D279" /incds=0 /nref=9 /ntot=187 /MaxReadThrough="1.63268" /MaxDrop="2.98181" /score="0.51805655" /energy="-13" /TU="NA" /idTUdmin="U450" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(583351..583848) /gene="ydhH" /locus_tag="BSU_05760" /old_locus_tag="BSU05760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388457.1" /db_xref="EnsemblGenomes-Gn:BSU05760" /db_xref="EnsemblGenomes-Tr:CAB12395" /db_xref="GOA:O05500" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG12185" /db_xref="UniProtKB/Swiss-Prot:O05500" /translation="MSSHYKYPLIFTAFLLIAFCLIFFSYHLIHHVRLEYPNWQGESK DQNWEAVFTKNEDAPNEYSGKLYWIGDTIEIDNTYLESLIVKKDDEVLLSSDTEIPMH DYAGGTFSDGSAKEKSVSFLERLDEHELEGHDITIEVKWKQGNHYSASQLTLNEKTLF DEKQQ*" /label="ydhH CDS" gene complement(583351..583848) /gene="ydhH" /locus_tag="BSU_05760" /old_locus_tag="BSU05760" /label="ydhH gene" CDS complement(583866..584348) /gene="ydhI" /locus_tag="BSU_05770" /old_locus_tag="BSU05770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388458.1" /db_xref="EnsemblGenomes-Gn:BSU05770" /db_xref="EnsemblGenomes-Tr:CAB12396" /db_xref="GOA:O05501" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12186" /db_xref="UniProtKB/Swiss-Prot:O05501" /translation="MMIIIPNNEIAKHMLTDFFAKHWGTPEMAISSGIFRCDELDGFA AVNESGEIIGCITYTIDGKDCEIISLDSMIENKGIGTALLQQVEEKAKHAHCQRIKLI TTNDNVNAIAFYQKRGYQFAAVFPNAVEKARRLKPEIPEVAENGILIRDEILFSKVID *" /label="ydhI CDS" gene complement(583866..584348) /gene="ydhI" /locus_tag="BSU_05770" /old_locus_tag="BSU05770" /label="ydhI gene" promotor_-35 584021..584028 /Source="Nicolas_upshift_promotors" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 584042..584061 /Source="Nicolas_upshift_promotors" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 584046 /Source="Nicolas_upshifts" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(584377..584396) /Source="Nicolas_upshift_promotors" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(584387) /Source="Nicolas_upshifts" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(584411..584414) /Source="Nicolas_upshift_promotors" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 584431..585408 /gene="ydhJ" /locus_tag="BSU_05780" /old_locus_tag="BSU05780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_388459.1" /db_xref="EnsemblGenomes-Gn:BSU05780" /db_xref="EnsemblGenomes-Tr:CAB12397" /db_xref="GOA:O05502" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG12187" /db_xref="UniProtKB/Swiss-Prot:O05502" /translation="MEISDIIYGQHHIDGVLEELIKSAPVQRLKGIYQGGASFLVNRK WNVTRYEHSIGVMLLIKKLGGTIEEQIAGLLHDVSHTAFSHVVDVVFENQAEDYHENI FQQVIVHSEIPDILQKHGYHTEELLSDDSRWTLLEQPAPELCADRTDYTLRDMYRYGH INLHEAQTFLDHLIVRNGRMFPDSIEAAEWFVSVYYKEVIDFFLNPVNVYGYEYLARA LKAALRHDVISAEDLLKTDQEVLNILRASKNEEVLSLLTSIHPGIQVIEDDIQYDFHQ KKKMRLIDPSIFLDDKWIKSSGVSEKVRKMGEAAYQKAKKGVYIKILKQ*" /label="ydhJ CDS" gene 584431..585408 /gene="ydhJ" /locus_tag="BSU_05780" /old_locus_tag="BSU05780" /label="ydhJ gene" downshifts 585388 /Source="Nicolas_upshifts" /id="D280" /incds=0 /nref=2 /ntot=92 /MaxReadThrough="2.31799" /MaxDrop="3.19063" /score="28.8500849" /energy="-8.1" /TU="NA" /idTUdmin="U451" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 585435..585441 /Source="Nicolas_upshift_promotors" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 585456..585474 /Source="Nicolas_upshift_promotors" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 585464 /Source="Nicolas_upshifts" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 585500..585507 /Source="Nicolas_upshift_promotors" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 585520 /Source="Nicolas_upshifts" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 585521..585540 /Source="Nicolas_upshift_promotors" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 585550..586167 /gene="ydhK" /locus_tag="BSU_05790" /old_locus_tag="BSU05790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388460.1" /db_xref="EnsemblGenomes-Gn:BSU05790" /db_xref="EnsemblGenomes-Tr:CAB12398" /db_xref="InterPro:IPR011438" /db_xref="PDB:2KY9" /db_xref="PDB:4FIB" /db_xref="PDB:4MDW" /db_xref="SubtiList:BG12188" /db_xref="UniProtKB/Swiss-Prot:O05503" /translation="MSAGKSYRKKMKQRRMNMKISKYALGILMLSLVFVLSACGNNNS TKESTHDNHSDSSTHEEMDHSGSADVPEGLQESKNPKYKVGSQVIINTSHMKGMKGAE ATVTGAYDTTAYVVSYTPTNGGQRVDHHKWVIQEEIKDAGDKTLQPGDQVILEASHMK GMKGATAEIDSAEKTTVYMVDYTSTTSGEKVKNHKWVTEDELSAK*" /label="ydhK CDS" gene 585550..586167 /gene="ydhK" /locus_tag="BSU_05790" /old_locus_tag="BSU05790" /label="ydhK gene" downshifts 586154 /Source="Nicolas_upshifts" /id="D281" /incds=0 /nref=62 /ntot=212 /MaxReadThrough="1.07295" /MaxDrop="7.27889" /score="30.3859931" /energy="-11.4" /TU="U452" /idTUdmin="U451" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(586183..587349) /gene="pbuE" /locus_tag="BSU_05800" /old_locus_tag="BSU05800" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12923093, 15849754, 16850406, 17935948, 25573585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15849754, 16850406, 17935948, 25573585; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine efflux transporter" /protein_id="NP_388461.2" /db_xref="EnsemblGenomes-Gn:BSU05800" /db_xref="EnsemblGenomes-Tr:CAB12399" /db_xref="GOA:Q797E3" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12189" /db_xref="UniProtKB/Swiss-Prot:Q797E3" /translation="MNFKVFLLAASTIAVGLVELIVGGILPQIANDLDISIVSAGQLI SVFALGYAVSGPLLLALTAKIERKRLYLIALFVFFLSNLVAYFSPNFATLMVSRVLAA MSTGLIVVLSLTIAPKIVAPEYRARAIGIIFMGFSSAIALGVPLGILISDSFGWRILF LGIGLLALISMLIISIFFERIPAEKMIPFREQLKTIGNLKIASSHLVTMFTLAGHYTL YAYFAPFLEETLHLSSFWVSICYFLFGISAVCGGPFGGALSDRLGSFKSILLVTGSFA IIMFLLPLSTSSMIFFLPVMVIWGLLSWSLAPAQQSYLIEIAPDSSDIQQSFNTSALQ VGIALGSAIGGVVLDQTGTVVSTAWCGGSIVIIAVLFAFISLTRPVQTAKKSSL*" /label="pbuE CDS" gene complement(586183..587349) /gene="pbuE" /locus_tag="BSU_05800" /old_locus_tag="BSU05800" /label="pbuE gene" downshifts complement(586212) /Source="Nicolas_upshifts" /id="D282" /incds=0 /nref=40 /ntot=58 /MaxReadThrough="2.22188" /MaxDrop="4.89202" /score="36.362851" /energy="-12.4" /TU="NA" /idTUdmin="U453" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(587404..587504) /gene="aswA" /locus_tag="BSU_misc_RNA_8" /product="adenine riboswitch" /experiment="publication(s) with functional evidences, PMID:14718920, 16201765, 19603494, 20022916, 21283784, 23087247, 25573585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14718920, 16201765, 19603494, 20022916, 21283784, 23087247, 25573585; Product type n: RNA" /label="aswA RNA" gene complement(587404..587504) /gene="aswA" /locus_tag="BSU_misc_RNA_8" /label="aswA gene" downshifts complement(587445) /Source="Nicolas_upshifts" /id="D283" /incds=0 /nref=38 /ntot=127 /MaxReadThrough="5.85661" /MaxDrop="6.06248" /score="33.0784595" /energy="-19.4" /TU="U453" /idTUdmin="U453" /TUdmin="-1233" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(587514..587533) /Source="Nicolas_upshift_promotors" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(587528) /Source="Nicolas_upshifts" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(587549..587553) /Source="Nicolas_upshift_promotors" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 587612..587619 /Source="Nicolas_upshift_promotors" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 587633..587652 /Source="Nicolas_upshift_promotors" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 587640 /Source="Nicolas_upshifts" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="upshifts" CDS 587680..587991 /gene="gmuB" /locus_tag="BSU_05810" /old_locus_tag="BSU05810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18177310; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIB" /protein_id="NP_388462.1" /db_xref="EnsemblGenomes-Gn:BSU05810" /db_xref="EnsemblGenomes-Tr:CAB12400" /db_xref="GOA:O05505" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG12190" /db_xref="UniProtKB/Swiss-Prot:O05505" /translation="MKKILLACSSGMSTSLLVTKMKEYAQSIGEEAEIWAVGQDKAKE DMRKADAVLIGPQMSFLKSELQKEADQYNIQVEVIDMMAYGMADGKKAYEQALSLMVN Q*" /label="gmuB CDS" gene 587680..587991 /gene="gmuB" /locus_tag="BSU_05810" /old_locus_tag="BSU05810" /label="gmuB gene" CDS 587991..588323 /gene="gmuA" /locus_tag="BSU_05820" /old_locus_tag="BSU05820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIA" /protein_id="NP_388463.2" /db_xref="EnsemblGenomes-Gn:BSU05820" /db_xref="EnsemblGenomes-Tr:CAB12401" /db_xref="GOA:O05506" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG12191" /db_xref="UniProtKB/Swiss-Prot:O05506" /translation="MEQMKITNLTDEQISFQLILHSGNARSCIIQSLRAYKEGKKDEA DALIAKAEQDLSAAHDIHFQMIQKESGGEATAFSLLLMHAEDHLMSTLSMKELVKEML DLFKTKNI*" /label="gmuA CDS" gene 587991..588323 /gene="gmuA" /locus_tag="BSU_05820" /old_locus_tag="BSU05820" /label="gmuA gene" CDS 588342..589670 /gene="gmuC" /locus_tag="BSU_05830" /old_locus_tag="BSU05830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18177310; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIC" /protein_id="NP_388464.1" /db_xref="EnsemblGenomes-Gn:BSU05830" /db_xref="EnsemblGenomes-Tr:CAB12402" /db_xref="GOA:O05507" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG12192" /db_xref="UniProtKB/Swiss-Prot:O05507" /translation="MFEKISQFLVPIAGRLNNNRYLQVLRDAFMLAFPLTIFGSIFVV LTNLPFLNKIMNASMLTSFQSHFGIASTATMGIMSVFVVFGIGYYLSKSYQVEAVFGG AIALVSFLLLTPFIIQPETGDAITGVIPVDRLGAKGMFLGMITAFLSGEIYRRIVQKN LTIKMPAGVPPAVAKSFAALIPAFITLTVFLLINVMVTLFFKTNMHDVIYHAIQAPLV GLGSGIIPTLIAVFFIQILWFFGLHGQIIINSVMDPIWNTLQVENLSAYTAGKEIPHI ISKPFMEIYTVGMGGTGMTLAIVFTILIFMKSRQMKQVSKLGLAPGIFNVNEPIIFGL PIVMNPIIIVPWVLAPMVVTLVTYLAMSAGLVPPPTGVTVPWTVPLFINGIMATNSIM GGVMQLINLLIVFVIWFPFLKAMDKLNLAKEKEQAVQETAAQQNDNSIKM*" /label="gmuC CDS" gene 588342..589670 /gene="gmuC" /locus_tag="BSU_05830" /old_locus_tag="BSU05830" /label="gmuC gene" CDS 589688..591085 /gene="gmuD" /locus_tag="BSU_05840" /old_locus_tag="BSU05840" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18177310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18177310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannoside-phospho-beta-d-glucosidase" /protein_id="NP_388465.1" /db_xref="EnsemblGenomes-Gn:BSU05840" /db_xref="EnsemblGenomes-Tr:CAB12403" /db_xref="GOA:O05508" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="SubtiList:BG12193" /db_xref="UniProtKB/Swiss-Prot:O05508" /translation="MAHTEQYRFPKDFWWGSSASATQMEGAADRDGKGQNIWDYWFEK EPHRFFDHVGPADTSQFYDNYKEDIRLMKELGHNSFRMSISWSRLIPNGTGEINDKAA DFYNNVIDELIANGIEPFVNLFHFDMPMALQKIGGWVNRETVDAYENYARTCFRLFGG RVKKWFTHNEPIVPVEGGYLYDFHYPNKVDFKEAVQVGFHTMLSSARAIQAYREMKQD GKIGIILNLTPSYPRSSHPADVKAGEIADAFFNRSFLDPSVKGEFPKELVDILKHEGF MPDYNAEDLDIIKKNTVDLLGVNYYQPRRVKAKEHLPNPDAPFLPDRYFDPYVMPGRK MNPHRGWEIYEKGVYDILINLKENYGNIECFISENGMGVEGEERFRDEQGIIQDDYRI EFIKEHLKWIHRAIQEGSNVKGYHLWTFMDNWSWTNAYKNRYGFVSVNLEKDGERTVK KSGKWFKEVAEHSGF*" /label="gmuD CDS" gene 589688..591085 /gene="gmuD" /locus_tag="BSU_05840" /old_locus_tag="BSU05840" /label="gmuD gene" S_feature 591086..591172 /Source="Nicolas_S_feature" /locus_tag="new_630028_630114" /HighExp="G150, T0.30H, T1.0H, M40t90, T1.30H, Mt0, M0t90, Lbexp, dia0, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S203" promotor_-35 591150..591157 /Source="Nicolas_upshift_promotors" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 591171..591190 /Source="Nicolas_upshift_promotors" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 591174 /Source="Nicolas_upshifts" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="upshifts" CDS 591228..591941 /gene="gmuR" /locus_tag="BSU_05850" /old_locus_tag="BSU05850" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18177310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18177310; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388466.1" /db_xref="EnsemblGenomes-Gn:BSU05850" /db_xref="EnsemblGenomes-Tr:CAB12404" /db_xref="GOA:O05509" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12194" /db_xref="UniProtKB/Swiss-Prot:O05509" /translation="MNKYEIIANEMRNRIKNNVYPIDQPIPDEVSLAKEFNSSRMTMK RALDNLVAEGLLFRKRGHGTFIIQSAIQDDHVHVVSNEILGLTNLLKDKKIKSKVIQF EVQFPTEEVAAHLSIDQKTPVYYVVRLRIVEGEPYVLEKTYMPTHLIPGINDDVLHDS IYNHITNVLQLKIAGTHRKIRACKSDHIDQQHLGCKQDDPILEVEHVGFLDTGIPFEY SFSRHRHDKFVVTSVNIRR*" /label="gmuR CDS" gene 591228..591941 /gene="gmuR" /locus_tag="BSU_05850" /old_locus_tag="BSU05850" /label="gmuR gene" CDS 591970..592869 /gene="gmuE" /locus_tag="BSU_05860" /old_locus_tag="BSU05860" /EC_number="2.7.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15018644, 18177310, 21185308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15018644, 18177310, 21185308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ROK fructokinase; glucomannan utilization protein E" /protein_id="NP_388467.1" /db_xref="EnsemblGenomes-Gn:BSU05860" /db_xref="EnsemblGenomes-Tr:CAB12405" /db_xref="GOA:O05510" /db_xref="InterPro:IPR000600" /db_xref="PDB:1XC3" /db_xref="PDB:3LM9" /db_xref="PDB:3OHR" /db_xref="SubtiList:BG12195" /db_xref="UniProtKB/Swiss-Prot:O05510" /translation="MLGGIEAGGTKFVCAVGREDGTIIDRIEFPTKMPDETIEKVIQY FSQFSLQAIGIGSFGPVDNDKTSQTYGTITATPKAGWRHYPFLQTVKNEMKIPVGFST DVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLSHPEMGHIYIRRHP DDVYQGKCPYHGDCFEGLASGPAIEARWGKKAADLSDIAQVWELEGYYIAQALAQYIL ILAPKKIILGGGVMQQKQVFSYIYQYVPKIMNSYLDFSELSDDISDYIVPPRLGSNAG IIGTLVLAHQALQAEAASGEVRS*" /label="gmuE CDS" gene 591970..592869 /gene="gmuE" /locus_tag="BSU_05860" /old_locus_tag="BSU05860" /label="gmuE gene" CDS 592866..593813 /gene="gmuF" /locus_tag="BSU_05870" /old_locus_tag="BSU05870" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10704478, 18177310, 3017192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphohexomutase; cupin family" /protein_id="NP_388468.1" /db_xref="EnsemblGenomes-Gn:BSU05870" /db_xref="EnsemblGenomes-Tr:CAB12406" /db_xref="GOA:O05511" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG12196" /db_xref="UniProtKB/Swiss-Prot:O05511" /translation="MTHPLFLEPVFKERLWGGTKLRDAFGYAIPSQKTGECWAVSAHA HGSSSVKNGPLAGKTLDQVWKDHPEIFGFPDGKVFPLLVKLLDANMDLSVQVHPDDDY AKLHENGDLGKTECWYIIDCKDDAELILGHHASTKEEFKQRIESGDWNGLLRRIKIKP GDFFYVPSGTLHALCKGTLVLEIQQNSDTTYRVYDYDRCNDQGQKRTLHIEKAMEVIT IPHIDKVHTPEVKEVGNAEIIVYVQSDYFSVYKWKISGRAAFPSYQTYLLGSVLSGSG RIINNGIQYECNAGSHFILPAHFGEFTIEGTCEFMISHP*" /label="gmuF CDS" gene 592866..593813 /gene="gmuF" /locus_tag="BSU_05870" /old_locus_tag="BSU05870" /label="gmuF gene" CDS 593832..594920 /gene="gmuG" /locus_tag="BSU_05880" /old_locus_tag="BSU05880" /EC_number="3.2.1.78" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2694961, 7727534, 18177310, 28101462, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2694961, 7727534, 18177310, 28101462, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported mannan endo-1,4-beta-mannosidase" /protein_id="NP_388469.2" /db_xref="EnsemblGenomes-Gn:BSU05880" /db_xref="EnsemblGenomes-Tr:CAB12407" /db_xref="GOA:O05512" /db_xref="InterPro:IPR000805" /db_xref="InterPro:IPR016714" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR022790" /db_xref="PDB:2WHK" /db_xref="PDB:3CBW" /db_xref="SubtiList:BG12197" /db_xref="UniProtKB/Swiss-Prot:O05512" /translation="MFKKHTISLLIIFLLASAVLAKPIEAHTVSPVNPNAQQTTKTVM NWLAHLPNRTENRVLSGAFGGYSHDTFSMAEADRIRSATGQSPAIYGCDYARGWLETA NIEDSIDVSCNGDLMSYWKNGGIPQISLHLANPAFQSGHFKTPITNDQYKKILDSSTV EGKRLNAMLSKIADGLQELENQGVPVLFRPLHEMNGEWFWWGLTSYNQKDNERISLYK QLYKKIYHYMTDTRGLDHLIWVYSPDANRDFKTDFYPGASYVDIVGLDAYFQDAYSIN GYDQLTALNKPFAFTEVGPQTANGSFDYSLFINAIKQKYPKTIYFLAWNDEWSAAVNK GASALYHDSWTLNKGEIWNGDSLTPIVE*" /label="gmuG CDS" gene 593832..594920 /gene="gmuG" /locus_tag="BSU_05880" /old_locus_tag="BSU05880" /label="gmuG gene" downshifts 594914 /Source="Nicolas_upshifts" /id="D284" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="1.56881" /MaxDrop="2.87204" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U454" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(594981..595709) /gene="ydhUc" /locus_tag="BSU_05890" /old_locus_tag="BSU05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTFRETLAFLIVRDNAHQNAFAKALETLGVEWAKL LPVPNYDINKYPECRKYVELGYHNTHFNFRLDETRISEIYQGKSPSRNGGELQVIDPP AGFPVPVLPEIPNEHSPGLGDMNA*" /label="ydhUc CDS" gene complement(594981..595709) /gene="ydhUc" /locus_tag="BSU_05890" /old_locus_tag="BSU05890" /pseudo /label="ydhUc gene" downshifts complement(595031) /Source="Nicolas_upshifts" /id="D285" /incds=0 /nref=13 /ntot=37 /MaxReadThrough="1.1517" /MaxDrop="5.0503" /score="0.317473754" /energy="-17.6" /TU="NA" /idTUdmin="U456" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(595640..595834) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" /label="ydhUn CDS" gene complement(595640..595834) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo /label="ydhUn gene" promotor_-10 complement(595867..595878) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(595875) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(595892..595898) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 595953..595960 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 595974..595993 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 595976..596076 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 595978 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(596024) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" upshifts 596036 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 596044..596051 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 596065..596084 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 596080..596167 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 596080 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" tRNA 596168..596244 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Arg tRNA" gene 596168..596244 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /label="trnE-Arg gene" tRNA 596258..596331 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Gly tRNA" gene 596258..596331 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /label="trnE-Gly gene" rRNA 596491..598045 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-16S rRNA" gene 596491..598045 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /label="rrnE-16S gene" rRNA 598213..601140 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-23S rRNA" gene 598213..601140 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /label="rrnE-23S gene" rRNA 601196..601312 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-5S rRNA" gene 601196..601312 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /label="rrnE-5S gene" tRNA 601326..601402 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Met tRNA" gene 601326..601402 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /label="trnE-Met gene" tRNA 601463..601539 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Asp tRNA" gene 601463..601539 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /label="trnE-Asp gene" downshifts 601536 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" /label="downshifts" promotor_-35 601640..601644 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 601660..601679 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 601664 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="upshifts" CDS 601720..602697 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" /label="thiL CDS" gene 601720..602697 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /label="thiL gene" CDS 602712..603188 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" /label="tsaE CDS" gene 602712..603188 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /label="tsaE gene" CDS 603169..603858 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" /label="tsaB CDS" gene 603169..603858 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /label="tsaB gene" CDS 603868..604323 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" /label="rimI CDS" gene 603868..604323 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /label="rimI gene" CDS 604316..605356 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" /label="tsaD CDS" gene 604316..605356 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /label="tsaD gene" downshifts 605320 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(605586..607514) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" /label="ydiF CDS" gene complement(605586..607514) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /label="ydiF gene" downshifts complement(605603) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" misc_feature 607266..607285 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 607276 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" S_feature 607278..607467 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 607432..607439 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 607453..607472 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 607469..607639 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 607469 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(607534..607553) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(607546) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(607567..607574) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 607640..608152 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" /label="moaC CDS" gene 607640..608152 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /label="moaC gene" CDS 608149..608796 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" /label="rex CDS" gene 608149..608796 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /label="rex gene" promotor_no_box 608626..608726 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 608686 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" CDS 608818..608991 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" /label="tatAY CDS" gene 608818..608991 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /label="tatAY gene" CDS 608998..609762 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" /label="tatCY CDS" gene 608998..609762 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /label="tatCY gene" downshifts 609742 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(609800..609991) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" /label="ydiK CDS" gene complement(609800..609991) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /label="ydiK gene" downshifts complement(609817) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(609988..610722) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" /label="ydiL CDS" gene complement(609988..610722) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /label="ydiL gene" promotor_-35 610380..610385 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 610400..610418 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 610402 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 610721..610722 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 610732..610746 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 610754 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="upshifts" promotor_-10 complement(610759..610778) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 610776..610884 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(610779) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(610792..610797) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 610858..610864 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 610878..610897 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 610886..610960 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 610886 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="upshifts" CDS 610961..611245 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" /label="groES CDS" gene 610961..611245 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /label="groES gene" CDS 611292..612926 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" /label="groEL CDS" gene 611292..612926 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /label="groEL gene" S_feature 612927..613019 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 612976 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" /label="downshifts" CDS complement(613014..613142) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" /label="ydzTc CDS" gene complement(613014..613142) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo /label="ydzTc gene" S_feature 613021..>614247 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(613145..613303) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" /label="ydzT CDS" gene complement(613145..613303) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo /label="ydzT gene" CDS complement(613348..613476) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" /label="ydzT CDS" gene complement(613348..613476) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo /label="ydzT gene" CDS complement(613569..613778) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" /label="ydzT CDS" gene complement(613569..613778) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo /label="ydzT gene" CDS complement(613771..614076) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " /label="ydzTn CDS" gene complement(613771..614076) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo /label="ydzTn gene" SCAR join(614247,614254) /created_by="AR/SM" /note="deletion occured in betwen marked nucleotides" /label="Delta6_1" N_region 614248..614253 /note="KpnI site (GGTACC)" /created_by="User" /label="Delta6_1" CDS complement(614352..616841) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" /label="gutR CDS" gene complement(614352..616841) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /label="gutR gene" downshifts complement(614374) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(616855..616874) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(616881) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(616888..616895) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 616944..616945 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 616960..617042 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 616960 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 616961..616980 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 617043..618104 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" /label="gutB CDS" gene 617043..618104 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /label="gutB gene" CDS 618178..619569 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" /label="gutP CDS" gene 618178..619569 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /label="gutP gene" promotor_-35 619596..619603 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 619617..619636 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 619622 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="upshifts" CDS 619664..620626 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" /label="ydjE CDS" gene 619664..620626 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /label="ydjE gene" downshifts 620611 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 620751..620760 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 620767 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 620773..620788 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 620822..621505 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" /label="pspA CDS" gene 620822..621505 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /label="pspA gene" S_feature 621506..621570 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 621571..622596 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" /label="ydjG CDS" gene 621571..622596 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /label="ydjG gene" CDS 622596..623360 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" /label="ydjH CDS" gene 622596..623360 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /label="ydjH gene" CDS 623391..624362 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" /label="ydjI CDS" gene 623391..624362 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /label="ydjI gene" downshifts 624352 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 624396 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(624409..625434) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" /label="ydjJ CDS" gene complement(624409..625434) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /label="ydjJ gene" promotor_-10 complement(625466..625485) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(625484) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(625499..625505) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 625694..625701 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 625714 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="upshifts" S_feature 625716..626018 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 625716..625735 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 626019..627440 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" /label="iolT CDS" gene 626019..627440 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /label="iolT gene" downshifts 627432 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(627488) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(627488..628528) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" /label="bdhA CDS" gene complement(627488..628528) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /label="bdhA gene" promotor_-35 628068..628077 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 628091..628110 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 628092..628627 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 628092 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(628529..628823) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 628628..628647 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 628629..628926 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 628629 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="upshifts" misc_feature complement(628818..628832) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(628823) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 628925..628944 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 628928 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="upshifts" CDS 628967..629338 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" /label="walM CDS" gene 628967..629338 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /label="walM gene" downshifts 629324 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS 629404..630450 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" /label="ydjN CDS" gene 629404..630450 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /label="ydjN gene" downshifts 630424 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(630484..630642) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" /label="ydzJ CDS" gene complement(630484..630642) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /label="ydzJ gene" downshifts complement(630500) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(630699..630831) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(630742) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(630832..631041) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" /label="ydjO CDS" gene complement(630832..631041) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /label="ydjO gene" promotor_-10 complement(631074..631093) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(631085) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" CDS complement(631124..631939) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" /label="ydjP CDS" gene complement(631124..631939) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /label="ydjP gene" promotor_-35 631766..631775 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 631788..631807 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 631788 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(631952..632941) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" /label="yeaA CDS" gene complement(631952..632941) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /label="yeaA gene" promotor_-10 complement(632806..632824) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(632814) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(632840..632845) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(632963..632978) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(632984) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(632990..632999) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(633039..634580) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" /label="cotA CDS" gene complement(633039..634580) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /label="cotA gene" downshifts complement(633052) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(634611..634630) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(634625) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="upshifts" promotor_-35 complement(634644..634653) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(634732..636141) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" /label="gabP CDS" gene complement(634732..636141) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /label="gabP gene" downshifts complement(634746) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(636179..636466) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" /label="ydzX CDS" gene complement(636179..636466) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /label="ydzX gene" misc_feature complement(636182..636201) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(636196) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="upshifts" promotor_-35 636472..636479 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 636495..636514 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 636496 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="upshifts" CDS 636539..637411 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" /label="mneS CDS" gene 636539..637411 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /label="mneS gene" downshifts 637376 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(637651) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" /label="downshifts" misc_feature 637705..637724 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 637715 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="upshifts" CDS 637761..638723 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" /label="yeaC CDS" gene 637761..638723 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /label="yeaC gene" CDS 638723..639919 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" /label="yeaD CDS" gene 638723..639919 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /label="yeaD gene" CDS 639941..642154 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" /label="yebA CDS" gene 639941..642154 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /label="yebA gene" promotor_-35 642149..642156 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 642171..642190 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 642187..642316 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 642187 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="upshifts" CDS 642317..643858 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" /label="guaA CDS" gene 642317..643858 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /label="guaA gene" downshifts 643844 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 643965..643969 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 643985..644004 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 643995 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="upshifts" misc_RNA 644002..644104 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswC RNA" gene 644002..644104 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /label="gswC gene" downshifts 644130 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 644239..645561 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" /label="pbuG CDS" gene 644239..645561 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /label="pbuG gene" downshifts 645539 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 645582 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" /label="downshifts" promotor_-35 645611..645620 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 645631..645771 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 645631 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 645633..645648 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 645772..646575 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" /label="yebC CDS" gene 645772..646575 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /label="yebC gene" downshifts 646560 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 646643..646650 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 646664..646683 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 646670..646733 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 646670 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="upshifts" CDS 646734..646901 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" /label="yebD CDS" gene 646734..646901 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /label="yebD gene" downshifts 646908 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 646952..646958 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 646973..646991 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 646976..647062 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 646976 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 647041..647048 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 647062..647081 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 647064 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="upshifts" CDS 647115..647669 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" /label="yebE CDS" gene 647115..647669 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /label="yebE gene" CDS 647669..647866 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" /label="yebG CDS" gene 647669..647866 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /label="yebG gene" downshifts 647856 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 647912..647919 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 647934..647953 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 647936 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 647946..648048 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswD RNA" gene 647946..648048 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /label="gswD gene" S_feature 648049..648188 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 648189..648677 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" /label="purE CDS" gene 648189..648677 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /label="purE gene" CDS 648670..649812 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" /label="purK CDS" gene 648670..649812 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /label="purK gene" CDS 649809..651104 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" /label="purB CDS" gene 649809..651104 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /label="purB gene" promotor_-10 complement(650114..650133) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(650135) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(650148..650155) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 651178..651903 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" /label="purC CDS" gene 651178..651903 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /label="purC gene" CDS 651896..652150 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" /label="purS CDS" gene 651896..652150 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /label="purS gene" CDS 652147..652830 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" /label="purQ CDS" gene 652147..652830 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /label="purQ gene" CDS 652814..655042 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" /label="purL CDS" gene 652814..655042 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /label="purL gene" downshifts complement(653062) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" /label="downshifts" CDS 655018..656448 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" /label="purF CDS" gene 655018..656448 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /label="purF gene" S_feature 656449..656549 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 656550..657590 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" /label="purM CDS" gene 656550..657590 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /label="purM gene" CDS 657587..658174 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" /label="purN CDS" gene 657587..658174 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /label="purN gene" misc_feature 657597..657611 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 657606 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(657873..657891) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657880) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(657907..657912) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 658171..659709 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" /label="purH CDS" gene 658171..659709 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /label="purH gene" CDS 659725..660993 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" /label="purD CDS" gene 659725..660993 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /label="purD gene" downshifts 660978 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(661033..661452) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" /label="yezC CDS" gene complement(661033..661452) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /label="yezC gene" misc_feature complement(661522..661541) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(661531) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="upshifts" CDS 661596..662870 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" /label="yecA CDS" gene 661596..662870 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /label="yecA gene" downshifts 662819 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" /label="downshifts" CDS complement(662885..663112) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" /label="yezF CDS" gene complement(662885..663112) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /label="yezF gene" downshifts complement(662896) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(663113..663533) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 663180..663185 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 663196 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 663199..663218 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 663241..664983 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" /label="yerA CDS" gene 663241..664983 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /label="yerA gene" promotor_-10 complement(663518..663529) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(663533) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(663543..663549) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 663564 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" /label="downshifts" promotor_-35 664957..664963 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 664975 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 664976..664995 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 665010..666005 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" /label="yerB CDS" gene 665010..666005 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /label="yerB gene" CDS 666008..666322 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" /label="yerC CDS" gene 666008..666322 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /label="yerC gene" downshifts 666185 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" downshifts 666327 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" /label="downshifts" CDS complement(666357..667934) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" /label="yerD CDS" gene complement(666357..667934) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /label="yerD gene" downshifts complement(666371) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(667948..667967) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(667967) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(667982..667988) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 668131..668134 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 668148 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 668151..668170 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 668199..668885 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" /label="pcrB CDS" gene 668199..668885 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /label="pcrB gene" CDS 668947..671166 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " /label="pcrA CDS" gene 668947..671166 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /label="pcrA gene" CDS 671190..673196 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" /label="ligA CDS" gene 671190..673196 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /label="ligA gene" CDS 673212..674402 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" /label="yerH CDS" gene 673212..674402 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /label="yerH gene" misc_feature complement(673407..673411) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(673411) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 674439..674458 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 674447..674563 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 674447 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(674511) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" CDS 674564..675574 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" /label="yerI CDS" gene 674564..675574 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /label="yerI gene" promotor_no_box complement(674581..674681) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(674621) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 675557 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 675601..676405 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(675612..676310) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" /label="sapB CDS" gene complement(675612..676310) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /label="sapB gene" downshifts complement(675633) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(676330..676348) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(676351) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(676364..676369) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(676417..677895) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" /label="opuE CDS" gene complement(676417..677895) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /label="opuE gene" downshifts complement(676431) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" /label="downshifts" upshifts complement(677283) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(677286..677299) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(677896..678026) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(678017..678035) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(678026) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(678050..678056) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 678157..678160 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 678175..678308 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 678175 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 678177..678196 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 678309..678599 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" /label="gatC CDS" gene 678309..678599 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /label="gatC gene" CDS 678615..680072 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" /label="gatA CDS" gene 678615..680072 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /label="gatA gene" CDS 680086..681516 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" /label="gatB CDS" gene 680086..681516 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /label="gatB gene" downshifts 681497 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(681531..682400) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" /label="yerO CDS" gene complement(681531..682400) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /label="yerO gene" downshifts complement(681573) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 682190..682195 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 682211..682229 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 682223 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="upshifts" S_feature complement(682401..682475) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 682453..682460 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(682469..682488) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 682475 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 682476..682495 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(682482) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(682503..682510) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 682532..685690 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" /label="srfP CDS" gene 682532..685690 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /label="srfP gene" downshifts 685677 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 685929..685932 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 685947..685966 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 685955 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="upshifts" CDS 686013..686924 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" /label="dagK CDS" gene 686013..686924 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /label="dagK gene" S_feature 686925..687179 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 687180..688559 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" /label="rlmCD CDS" gene 687180..688559 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /label="rlmCD gene" S_feature 688560..689152 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(688572..689474) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" /label="yefB CDS" gene complement(688572..689474) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /label="yefB gene" downshifts 689109 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 689154..689454 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 689455..689790 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" /label="yefC CDS" gene 689455..689790 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /label="yefC gene" S_feature 689791..689864 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 689865..692504 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" /label="yeeA CDS" gene 689865..692504 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /label="yeeA gene" CDS 692516..694315 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" /label="yeeB CDS" gene 692516..694315 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /label="yeeB gene" promotor_-10 complement(692756..692771) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(692771) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(692783..692792) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 694316..694427 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 694428..695576 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" /label="yeeC CDS" gene 694428..695576 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /label="yeeC gene" S_feature 695577..696766 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(695838..696143) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " /label="yeeD CDS" gene complement(695838..696143) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /label="yeeD gene" CDS complement(696210..696416) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" /label="yezA CDS" gene complement(696210..696416) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /label="yezA gene" CDS complement(696656..697111) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" /label="yezG CDS" gene complement(696656..697111) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /label="yezG gene" downshifts complement(696669) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" /label="downshifts" CDS complement(697131..699140) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" /label="yeeF CDS" gene complement(697131..699140) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /label="yeeF gene" promotor_-10 complement(697498..697517) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(697505) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(697530..697535) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(699167..699186) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(699177) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="upshifts" CDS 699352..700374 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" /label="yeeG CDS" gene 699352..700374 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /label="yeeG gene" promotor_-35 700474..700481 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 700495..700514 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 700496 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="upshifts" CDS 700536..701666 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" /label="rapH CDS" gene 700536..701666 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /label="rapH gene" CDS 701656..701829 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" /label="phrH CDS" gene 701656..701829 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /label="phrH gene" downshifts 701784 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" /label="downshifts" S_feature 701830..701934 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 701901..701908 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 701923..701942 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 701936 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="upshifts" CDS 701989..702708 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" /label="yeeI CDS" gene 701989..702708 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /label="yeeI gene" downshifts complement(701991) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" /label="downshifts" promotor_-35 702566..702573 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 702587..702606 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 702597 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" downshifts 702690 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 702777..702786 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 702800..702819 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 702803 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(702807..702825) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(702827) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(702841..702846) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 702842..703279 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" /label="cotK CDS" gene 702842..703279 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /label="cotK gene" downshifts complement(702849) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" /label="downshifts" downshifts 703279 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 703339..703346 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 703362..703381 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 703367 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="upshifts" CDS 703394..703978 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" /label="yezE CDS" gene 703394..703978 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /label="yezE gene" downshifts 703959 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 704057..704500 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" /label="yesE CDS" gene 704057..704500 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /label="yesE gene" CDS 704497..705357 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" /label="yesF CDS" gene 704497..705357 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /label="yesF gene" promotor_-35 705419..705424 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 705440..705458 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 705440 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(705462..705476) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(705467) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(705484..705488) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 705484..705732 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" /label="cotJA CDS" gene 705484..705732 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /label="cotJA gene" CDS 705716..705979 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" /label="cotJB CDS" gene 705716..705979 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /label="cotJB gene" CDS 705994..706563 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" /label="cotJC CDS" gene 705994..706563 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /label="cotJC gene" S_feature 706564..706642 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 706615..706620 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 706635..706654 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 706644 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="upshifts" CDS 706688..707230 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" /label="yesJ CDS" gene 706688..707230 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /label="yesJ gene" downshifts 707197 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS 707253..707555 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" /label="yesK CDS" gene 707253..707555 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /label="yesK gene" promotor_-35 707598..707606 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 707617..707635 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 707623 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="upshifts" CDS 707670..708299 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" /label="yesL CDS" gene 707670..708299 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /label="yesL gene" CDS 708296..710029 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" /label="yesM CDS" gene 708296..710029 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /label="yesM gene" CDS 710029..711135 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" /label="yesN CDS" gene 710029..711135 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /label="yesN gene" downshifts 711089 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" promotor_-35 711174..711177 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 711192..711211 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 711199 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 711239..712522 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" /label="yesO CDS" gene 711239..712522 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /label="yesO gene" CDS 712519..713448 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" /label="rhgP CDS" gene 712519..713448 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /label="rhgP gene" CDS 713452..714342 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" /label="rhgQ CDS" gene 713452..714342 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /label="rhgQ gene" CDS 714358..715392 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" /label="rhgH CDS" gene 714358..715392 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /label="rhgH gene" CDS 715415..717700 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" /label="rhgR CDS" gene 715415..717700 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /label="rhgR gene" CDS 717714..718412 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" /label="rhgT CDS" gene 717714..718412 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /label="rhgT gene" CDS 718405..719067 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" /label="yesU CDS" gene 718405..719067 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /label="yesU gene" CDS 719064..719690 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" /label="yesV CDS" gene 719064..719690 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /label="yesV gene" CDS 719811..721673 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" /label="rhgW CDS" gene 719811..721673 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /label="rhgW gene" promotor_no_box 719851..719951 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 719911 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(720449) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(720450..720469) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(720482..720491) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 721719..723557 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" /label="rhgX CDS" gene 721719..723557 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /label="rhgX gene" CDS 723715..724368 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " /label="yesY CDS" gene 723715..724368 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /label="yesY gene" CDS 724376..726367 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" /label="rhgZ CDS" gene 724376..726367 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /label="rhgZ gene" CDS 726411..728984 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" /label="yetA CDS" gene 726411..728984 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /label="yetA gene" promotor_-10 complement(727733..727751) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(727746) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(727767..727772) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 729106..730614 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" /label="lplA CDS" gene 729106..730614 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /label="lplA gene" CDS 730669..731625 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" /label="lplB CDS" gene 730669..731625 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /label="lplB gene" downshifts complement(730943) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(730969..731069) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(731009) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 731639..732526 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" /label="lplC CDS" gene 731639..732526 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /label="lplC gene" promotor_-35 732273..732278 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 732294..732312 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 732297 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="upshifts" CDS 732535..733875 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" /label="lplD CDS" gene 732535..733875 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /label="lplD gene" S_feature complement(732969..734660) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 733876..733957 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 733958..734653 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" /label="yetF CDS" gene 733958..734653 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /label="yetF gene" downshifts 734651 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(734690..735016) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" /label="hmoA CDS" gene complement(734690..735016) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /label="hmoA gene" downshifts complement(734705) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 735003 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(735039..735058) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(735057) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(735073..735080) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(735120..735482) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" /label="yetH CDS" gene complement(735120..735482) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /label="yetH gene" promotor_-10 complement(735505..735524) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(735519) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="upshifts" promotor_-35 complement(735537..735543) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(735553..736113) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(735585) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(736096..736115) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(736113) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(736129..736138) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 736201..736208 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 736217 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 736221..736240 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 736266..736847 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" /label="yetI CDS" gene 736266..736847 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo /label="yetI gene" CDS 736841..737137 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" /label="yetI CDS" gene 736841..737137 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo /label="yetI gene" downshifts 737129 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 737208..737215 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 737229..737248 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 737237 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 737292..737459 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" /label="yezD CDS" gene 737292..737459 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /label="yezD gene" promotor_-35 737501..737508 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 737524..737543 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 737525 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 737569..738213 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" /label="calJ CDS" gene 737569..738213 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /label="calJ gene" downshifts 738149 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" /label="downshifts" downshifts 738193 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" CDS 738213..739205 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" /label="yetK CDS" gene 738213..739205 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /label="yetK gene" downshifts 739139 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 739183 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(739229..739732) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" /label="flvL CDS" gene complement(739229..739732) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /label="flvL gene" promotor_-10 complement(739757..739776) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(739765) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(739790..739797) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 739895..741004 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" /label="flvM CDS" gene 739895..741004 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /label="flvM gene" downshifts 740987 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS complement(741039..742109) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" /label="yetN CDS" gene complement(741039..742109) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /label="yetN gene" downshifts complement(741063) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(742140..742159) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(742166) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(742174..742181) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 742189..742195 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 742210..742228 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 742219 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="upshifts" CDS 742259..745444 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" /label="cypD CDS" gene 742259..745444 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /label="cypD gene" downshifts 745431 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 745494..745499 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 745515..745533 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 745536 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 745564..745567 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 745584..745603 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 745585..745890 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 745585 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" CDS 745891..747810 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" /label="ltaSA CDS" gene 745891..747810 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /label="ltaSA gene" downshifts 747809 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 747898..747907 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 747917..748045 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 747917 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 747921..747940 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(747971) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" /label="downshifts" CDS 748046..748810 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" /label="spmH CDS" gene 748046..748810 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /label="spmH gene" CDS 748817..749785 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" /label="spmG CDS" gene 748817..749785 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /label="spmG gene" CDS 749809..750720 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" /label="yfnF CDS" gene 749809..750720 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /label="yfnF gene" promotor_-35 750598..750607 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 750620..750639 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 750623 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" CDS 750749..751927 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" /label="yfnE CDS" gene 750749..751927 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /label="yfnE gene" promotor_-35 751468..751474 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 751489..751508 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 751503 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 751928..752863 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" /label="yfnD CDS" gene 751928..752863 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /label="yfnD gene" downshifts 752735 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 752845 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(752886) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" /label="downshifts" CDS complement(752894..754123) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" /label="yfnC CDS" gene complement(752894..754123) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /label="yfnC gene" promotor_-10 complement(754152..754171) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(754170) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(754187..754194) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(754234..754941) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" /label="pynN CDS" gene complement(754234..754941) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /label="pynN gene" downshifts complement(754263) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(754964..754983) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(754987) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(755033..756418) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" /label="mtrA CDS" gene complement(755033..756418) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /label="mtrA gene" downshifts complement(755055) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(756467..756486) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(756484) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(756501..756508) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 756586..756593 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 756601 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 756607..756625 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 756668..758125 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" /label="vdhT CDS" gene 756668..758125 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /label="vdhT gene" promotor_-10 complement(757461..757480) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(757475) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(757493..757502) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 758139..758999 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" /label="yfmS CDS" gene 758139..758999 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /label="yfmS gene" downshifts 758983 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 759067..759074 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 759088..759107 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 759093 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="upshifts" CDS 759134..761023 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" /label="ettA CDS" gene 759134..761023 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /label="ettA gene" downshifts 761007 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" misc_feature 761087..761106 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 761095 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="upshifts" CDS 761146..761592 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" /label="yfmQ CDS" gene 761146..761592 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /label="yfmQ gene" downshifts complement(761148) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(761232..761235) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(761237) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(761253..761254) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 761579 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 761655..761662 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 761676..761695 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 761688 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="upshifts" CDS 761717..762139 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" /label="copP CDS" gene 761717..762139 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /label="copP gene" downshifts 761975 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS 762205..763395 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" /label="copO CDS" gene 762205..763395 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /label="copO gene" downshifts complement(763459) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS 763686..763841 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" /label="yfmN CDS" gene 763686..763841 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /label="yfmN gene" CDS complement(763961..765517) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" /label="ettM CDS" gene complement(763961..765517) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /label="ettM gene" downshifts complement(763985) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 765347..765353 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 765368..765379 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 765385 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(765567..765586) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(765571) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(765602..765606) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 765627..765630 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 765646..765665 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 765649 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" CDS 765690..766820 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" /label="yfmL CDS" gene 765690..766820 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /label="yfmL gene" downshifts 766803 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS 766888..767334 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" /label="yfmK CDS" gene 766888..767334 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /label="yfmK gene" CDS complement(767387..768406) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" /label="yfmJ CDS" gene complement(767387..768406) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /label="yfmJ gene" downshifts complement(767397) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(768427..768446) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(768431) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(768433..768887) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(768459..768466) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 768525..768532 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 768546..768565 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 768553..769650 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 768553 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="upshifts" CDS complement(768888..770108) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" /label="yfmI CDS" gene complement(768888..770108) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /label="yfmI gene" promotor_-10 complement(770145..770164) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(770152) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(770180..770187) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 770206..770213 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 770225..770400 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 770225 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 770228..770247 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 770357 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 770444..771907 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" /label="yfmG CDS" gene 770444..771907 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /label="yfmG gene" S_feature complement(770809..772479) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 771908..772401 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 772389..772394 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 772403..775668 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 772403 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 772410..772428 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(772480..773280) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" /label="fecF CDS" gene complement(772480..773280) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /label="fecF gene" CDS complement(773293..774294) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " /label="fecE CDS" gene complement(773293..774294) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /label="fecE gene" promotor_-10 complement(773880..773899) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(773892) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(773914..773921) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(774291..775292) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " /label="fecD CDS" gene complement(774291..775292) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /label="fecD gene" misc_feature complement(775362..775381) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(775364..776311) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" /label="fecC CDS" gene complement(775364..776311) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /label="fecC gene" downshifts complement(775383) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" upshifts complement(775383) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 775638..775643 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 775659..775677 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 775670..776295 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 775670 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="upshifts" misc_feature 776291..776310 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 776297..776828 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 776297 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(776353..776372) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(776360) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(776386..776393) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(776420..776788) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" /label="yfmB CDS" gene complement(776420..776788) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /label="yfmB gene" S_feature complement(776789..776901) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(776890..776909) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(776901) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="upshifts" promotor_-35 complement(776921..776928) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 776969..776975 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 776989..777007 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 776989 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 777032..777379 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" /label="yflT CDS" gene 777032..777379 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /label="yflT gene" downshifts complement(777033) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" downshifts 777375 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 777420..777500 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 777501..777520 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 777502 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="upshifts" CDS 777570..778832 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" /label="pelA CDS" gene 777570..778832 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /label="pelA gene" downshifts 778827 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-35 778885..778888 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 778903..778922 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 778911 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 778959..780395 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" /label="maeS CDS" gene 778959..780395 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /label="maeS gene" downshifts 780387 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature 780486..780505 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 780497 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="upshifts" CDS 780522..782150 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" /label="citS CDS" gene 780522..782150 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /label="citS gene" CDS 782122..782802 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" /label="citT CDS" gene 782122..782802 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /label="citT gene" CDS 782805..783764 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" /label="yflP CDS" gene 782805..783764 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /label="yflP gene" downshifts 783733 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 783856..783863 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 783876..783895 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 783887..783959 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 783887 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="upshifts" CDS 783960..785261 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" /label="citM CDS" gene 783960..785261 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /label="citM gene" promotor_-35 785258..785264 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 785278..785289 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 785279 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="upshifts" CDS 785317..786111 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" /label="yflN CDS" gene 785317..786111 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /label="yflN gene" downshifts 786087 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-35 786166..786169 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 786184..786203 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 786197 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="upshifts" CDS 786230..787321 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" /label="nosA CDS" gene 786230..787321 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /label="nosA gene" CDS complement(787312..787587) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" /label="acyP CDS" gene complement(787312..787587) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /label="acyP gene" S_feature 787322..787653 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(787601..787620) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(787615) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(787635..787642) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 787654..788319 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" /label="yflK CDS" gene 787654..788319 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /label="yflK gene" CDS complement(788360..788497) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" /label="yflJ CDS" gene complement(788360..788497) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /label="yflJ gene" downshifts complement(788374) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(788498..788628) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(788614..788632) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 788624..788629 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(788628) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 788639..789703 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 788640 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 788645..788663 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(788648..788653) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(788654..788809) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" /label="yflI CDS" gene complement(788654..788809) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /label="yflI gene" S_feature complement(788810..788915) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(788916..789230) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" /label="yflH CDS" gene complement(788916..789230) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /label="yflH gene" S_feature complement(789231..789311) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(789312..790061) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" /label="mapB CDS" gene complement(789312..790061) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /label="mapB gene" promotor_-10 complement(790090..790109) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(790103) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(790105..791241) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(790121..790129) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 790172..790173 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 790193..790212 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 790196 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="upshifts" CDS 790233..791591 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" /label="nagP CDS" gene 790233..791591 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /label="nagP gene" promotor_-10 complement(791227..791246) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(791241) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(791260..791269) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 791477 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 791587 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(791624..793573) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" /label="ltaSB CDS" gene complement(791624..793573) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /label="ltaSB gene" downshifts complement(791641) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 792683..792689 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 792705..792723 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 792709..793673 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 792709 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(793574..793648) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(793625..793644) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(793648) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(793650..794172) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(793660..793664) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 793674..793811 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" /label="yflD CDS" gene 793674..793811 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /label="yflD gene" upshifts 793789 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="upshifts" misc_feature 793790..793809 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 793830..794222 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" /label="yflB CDS" gene 793830..794222 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /label="yflB gene" promotor_-10 complement(794170..794188) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(794185) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(794204..794209) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 794291..794297 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 794312..794330 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 794312 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="upshifts" CDS 794347..795762 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" /label="yflA CDS" gene 794347..795762 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /label="yflA gene" downshifts complement(794348) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(794374..794474) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(794414) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(795759..796835) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" /label="yfkT CDS" gene complement(795759..796835) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /label="yfkT gene" S_feature 795763..799129 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(796859..797059) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" /label="yfkS CDS" gene complement(796859..797059) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /label="yfkS gene" CDS complement(797075..798229) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" /label="yfkR CDS" gene complement(797075..798229) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /label="yfkR gene" CDS complement(798210..799751) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" /label="yfkQ CDS" gene complement(798210..799751) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /label="yfkQ gene" promotor_-10 complement(799801..799812) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(799804) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(799826..799832) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 799861..799868 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 799883..799902 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 799890 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(799936) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 799944..801356 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" /label="treP CDS" gene 799944..801356 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /label="treP gene" promotor_no_box complement(799962..800062) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(800002) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 801427..803112 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" /label="treA CDS" gene 801427..803112 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /label="treA gene" promotor_-10 complement(801733..801748) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(801740) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(801761..801770) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 803085..803089 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 803105..803124 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 803108 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 803133..803849 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" /label="treR CDS" gene 803133..803849 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /label="treR gene" downshifts 803842 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" promotor_-35 803924..803927 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 803943..803962 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 803952 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 803989..804654 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" /label="hypO CDS" gene 803989..804654 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /label="hypO gene" downshifts 804635 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(804691..809079) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" /label="yfkN CDS" gene complement(804691..809079) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /label="yfkN gene" downshifts complement(804710) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(809112..809131) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(809129) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(809146..809149) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 809256..809262 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 809276..809294 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 809279 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 809322..809840 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" /label="sufLB CDS" gene 809322..809840 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /label="sufLB gene" downshifts 809826 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" /label="downshifts" downshifts complement(809870) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" /label="downshifts" S_feature 809871..811521 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(809880..811070) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" /label="yfkL CDS" gene complement(809880..811070) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /label="yfkL gene" S_feature complement(811071..811162) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(811163..811378) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" /label="yfkK CDS" gene complement(811163..811378) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /label="yfkK gene" downshifts complement(811222) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(811410..811429) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(811424) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(811444..811445) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 811491..811498 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 811513..811532 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 811523 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 811581..812051 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" /label="yfkJ CDS" gene 811581..812051 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /label="yfkJ gene" CDS 812069..812389 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" /label="yfkI CDS" gene 812069..812389 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /label="yfkI gene" CDS 812413..813240 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " /label="rbn CDS" gene 812413..813240 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /label="rbn gene" promotor_-35 813219..813225 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 813240..813251 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 813258..813414 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 813258 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(813290) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" /label="downshifts" downshifts 813389 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(813439..814614) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " /label="yfkF CDS" gene complement(813439..814614) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /label="yfkF gene" downshifts complement(813444) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" /label="downshifts" promotor_-35 814051..814057 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 814073..814091 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 814077..814730 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 814077 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(814639..814658) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(814654) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(814672..814679) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 814720..814725 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 814732 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 814740..814758 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 814782..815837 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" /label="chaA CDS" gene 814782..815837 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /label="chaA gene" promotor_-35 815851..815857 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 815872..815883 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 815876 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="upshifts" CDS 815908..816702 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" /label="yfkD CDS" gene 815908..816702 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /label="yfkD gene" downshifts 816690 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(816741..817583) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" /label="mscC CDS" gene complement(816741..817583) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /label="mscC gene" downshifts complement(816743) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(817584..818705) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" /label="yfkA CDS" gene complement(817584..818705) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /label="yfkA gene" promotor_-10 complement(818746..818765) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(818764) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(818781..818785) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 818793..818800 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 818814..818833 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 818824 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="upshifts" CDS 818850..819035 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" /label="yfjT CDS" gene 818850..819035 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /label="yfjT gene" downshifts 819014 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" /label="downshifts" promotor_-35 819078..819084 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 819090 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 819099..819110 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 819136..819927 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" /label="pdaA CDS" gene 819136..819927 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /label="pdaA gene" downshifts 819925 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(819965..820825) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" /label="yfjR CDS" gene complement(819965..820825) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /label="yfjR gene" downshifts complement(819979) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(820845..820864) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(820859) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(820880..820883) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(820924..821883) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" /label="yfjQ CDS" gene complement(820924..821883) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /label="yfjQ gene" downshifts complement(820947) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(821894..821913) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(821897) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(821929..821932) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 821944..821948 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 821962..821981 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 821971 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="upshifts" CDS 822002..822865 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" /label="yfjP CDS" gene 822002..822865 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /label="yfjP gene" S_feature 822866..822978 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 822979..824379 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" /label="yfjO CDS" gene 822979..824379 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /label="yfjO gene" downshifts 824391 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 824685..824692 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 824708..824727 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 824714 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="upshifts" S_feature 824721..825004 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 825005..825271 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" /label="yfzA CDS" gene 825005..825271 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /label="yfzA gene" promotor_-10 complement(825219..825238) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(825237) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(825253..825256) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 825272..825753 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 825724..825727 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 825744..825763 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 825755..826002 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 825755 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 826003..826980 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" /label="dusC CDS" gene 826003..826980 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /label="dusC gene" S_feature 826981..827073 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 827030 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" /label="downshifts" promotor_-35 827114..827120 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 827132..827151 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 827141 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 827176..827628 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" /label="yfjM CDS" gene 827176..827628 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /label="yfjM gene" CDS 827658..828347 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" /label="yfjL CDS" gene 827658..828347 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /label="yfjL gene" downshifts 828352 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" /label="downshifts" misc_feature 828524..828542 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 828531 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 828579..829580 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " /label="acoA CDS" gene 828579..829580 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /label="acoA gene" CDS 829584..830612 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" /label="acoB CDS" gene 829584..830612 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /label="acoB gene" CDS 830626..831822 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" /label="acoC CDS" gene 830626..831822 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /label="acoC gene" downshifts complement(830627) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" /label="downshifts" CDS 831843..833219 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" /label="acoL CDS" gene 831843..833219 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /label="acoL gene" downshifts 833213 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" /label="downshifts" promotor_-35 833266..833273 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 833286..833305 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 833294 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 833335..835152 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" /label="acoR CDS" gene 833335..835152 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /label="acoR gene" promotor_-35 835153..835159 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 835171 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 835174..835185 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 835206..835385 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" /label="sspH CDS" gene 835206..835385 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /label="sspH gene" downshifts 835369 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(835421..835750) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" /label="yfjF CDS" gene complement(835421..835750) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /label="yfjF gene" downshifts complement(835435) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(835800..836258) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" /label="yfjE CDS" gene complement(835800..836258) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /label="yfjE gene" S_feature complement(836259..836351) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(836352..836909) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" /label="yfjD CDS" gene complement(836352..836909) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /label="yfjD gene" promotor_-35 836775..836780 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 836788 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 836795..836813 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 836799..837386 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(836941..837708) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" /label="yfjC CDS" gene complement(836941..837708) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /label="yfjC gene" CDS complement(837720..838943) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" /label="yfjB CDS" gene complement(837720..838943) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /label="yfjB gene" CDS complement(838949..839263) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" /label="yfjA CDS" gene complement(838949..839263) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /label="yfjA gene" promotor_-10 complement(839311..839330) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(839324) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(839345..839348) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 839555..839574 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 839558 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="upshifts" CDS 839599..840948 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " /label="malA CDS" gene 839599..840948 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /label="malA gene" misc_feature 840977..840996 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 840979 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="upshifts" CDS 841013..841777 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" /label="malR CDS" gene 841013..841777 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /label="malR gene" promotor_-10 complement(841157..841171) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(841187..841193) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(841187) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 841792..843375 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" /label="malP CDS" gene 841792..843375 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /label="malP gene" downshifts 843355 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" /label="downshifts" promotor_-35 843404..843411 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 843426..843445 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 843434 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="upshifts" CDS 843481..845202 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" /label="yfiB CDS" gene 843481..845202 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /label="yfiB gene" CDS 845196..847010 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" /label="yfiC CDS" gene 845196..847010 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /label="yfiC gene" downshifts 846985 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 847092..847099 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 847113..847132 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 847117 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="upshifts" CDS 847165..847569 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" /label="catD CDS" gene 847165..847569 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /label="catD gene" CDS 847587..848444 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" /label="catE CDS" gene 847587..848444 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /label="catE gene" downshifts 848431 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS 848538..849482 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" /label="yfiF CDS" gene 848538..849482 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /label="yfiF gene" downshifts complement(849349) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(849397..849497) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(849437) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 849657..851105 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" /label="yfiG CDS" gene 849657..851105 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /label="yfiG gene" CDS 851132..852073 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" /label="yfiH CDS" gene 851132..852073 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /label="yfiH gene" CDS 852083..853264 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" /label="yfiI CDS" gene 852083..853264 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /label="yfiI gene" downshifts 853254 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" /label="downshifts" promotor_-35 853324..853330 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 853345..853364 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 853363 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="upshifts" CDS 853388..854590 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" /label="linJ CDS" gene 853388..854590 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /label="linJ gene" CDS 854587..855249 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" /label="linK CDS" gene 854587..855249 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /label="linK gene" downshifts 855257 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 855393..856328 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" /label="bifL CDS" gene 855393..856328 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /label="bifL gene" CDS 856341..857531 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" /label="bifM CDS" gene 856341..857531 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /label="bifM gene" CDS 857545..858702 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" /label="bifN CDS" gene 857545..858702 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /label="bifN gene" promotor_-35 857656..857661 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 857676..857694 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 857677 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(858700..858774) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(858743) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(858775..859323) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" /label="padR CDS" gene complement(858775..859323) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /label="padR gene" S_feature complement(859324..859403) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(859392..859411) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(859403) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(859425..859430) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 859526..859529 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859545..859564 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859552 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="upshifts" CDS 859596..860228 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" /label="estB CDS" gene 859596..860228 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /label="estB gene" downshifts 860207 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" /label="downshifts" promotor_-35 860343..860348 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 860362..860381 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 860372 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="upshifts" CDS 860417..861505 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" /label="icaC CDS" gene 860417..861505 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /label="icaC gene" S_feature complement(860907..861295) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(861295) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(861297..861316) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(861329..861337) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(861541..862158) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" /label="yfiR CDS" gene complement(861541..862158) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /label="yfiR gene" downshifts complement(861559) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(862124..863377) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" /label="yfiS CDS" gene complement(862124..863377) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /label="yfiS gene" promotor_-10 complement(862185..862204) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(862197) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(862218..862225) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(863411..863430) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(863429) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(863445..863452) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 863456..863475 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 863461 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="upshifts" CDS 863501..864037 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" /label="bstA CDS" gene 863501..864037 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /label="bstA gene" CDS complement(864034..865590) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" /label="yfiU CDS" gene complement(864034..865590) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /label="yfiU gene" promotor_-10 complement(865612..865630) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(865629) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(865646..865649) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(865701..866183) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" /label="yfiV CDS" gene complement(865701..866183) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /label="yfiV gene" downshifts complement(865717) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(866208..866227) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(866224) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(866242..866248) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 866269..866276 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 866290..866309 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 866298 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="upshifts" CDS 866355..868925 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" /label="mprF CDS" gene 866355..868925 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /label="mprF gene" downshifts 868896 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(868943..869920) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" /label="sxzY CDS" gene complement(868943..869920) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /label="sxzY gene" downshifts complement(868954) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 869935..869942 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(869947..869966) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 869957..869976 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 869959..870050 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 869959 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(869964) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(869981..869988) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 870051..871052 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " /label="sxzZ CDS" gene 870051..871052 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /label="sxzZ gene" CDS 871049..872080 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" /label="sxzA CDS" gene 871049..872080 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /label="sxzA gene" downshifts 872061 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 872131..872133 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 872149..872168 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 872152 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 872195..873076 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" /label="yfhB CDS" gene 872195..873076 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /label="yfhB gene" promotor_-35 873087..873094 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 873110..873129 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 873119 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 873164..873748 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" /label="yfhC CDS" gene 873164..873748 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /label="yfhC gene" downshifts 873735 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(873787..873978) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" /label="yfhD CDS" gene complement(873787..873978) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /label="yfhD gene" downshifts complement(873805) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" /label="downshifts" upshifts complement(874010) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(874013..874024) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(874039..874045) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(874045..874155) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" /label="yfhE CDS" gene complement(874045..874155) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /label="yfhE gene" promotor_-10 complement(874184..874195) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(874186) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(874210..874216) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(874210..875121) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" /label="yfhF CDS" gene complement(874210..875121) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /label="yfhF gene" promotor_-35 875007..875010 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875027..875046 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 875037..875209 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 875037 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(875143..875161) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(875157) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(875175..875181) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 875210..876004 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" /label="recX CDS" gene 875210..876004 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /label="recX gene" CDS 876006..876320 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" /label="yfhH CDS" gene 876006..876320 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /label="yfhH gene" S_feature complement(876228..876496) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 876310 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 876394..876399 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 876415..876434 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 876420 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" CDS 876463..877656 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" /label="yfhI CDS" gene 876463..877656 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /label="yfhI gene" S_feature 877657..877891 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(877689..877841) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" /label="sspK CDS" gene complement(877689..877841) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /label="sspK gene" downshifts complement(877706) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 877870..877877 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877891..877910 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 877893..877965 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 877893 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(877900..877911) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(877910) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(877926..877932) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 877966..878235 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" /label="yfhJ CDS" gene 877966..878235 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /label="yfhJ gene" downshifts 878224 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 878313..878319 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 878334 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 878335..878353 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 878380..878898 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" /label="yfhK CDS" gene 878380..878898 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /label="yfhK gene" S_feature 878899..878966 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 878934..878943 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 878955..878970 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 878968 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="upshifts" CDS 878983..879315 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" /label="spdL CDS" gene 878983..879315 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /label="spdL gene" CDS 879302..880162 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" /label="ephM CDS" gene 879302..880162 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /label="ephM gene" downshifts 880160 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 880220..880226 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 880240..880251 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 880248..880312 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 880248 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(880270..880289) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(880279) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 880295..880301 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(880303..880304) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 880314..880394 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 880314 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 880316..880334 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 880395..881384 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" /label="csbB CDS" gene 880395..881384 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /label="csbB gene" upshifts complement(880544) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(880549..880553) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(880570..880574) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 881385..881455 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 881456..884041 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" /label="yfhO CDS" gene 881456..884041 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /label="yfhO gene" downshifts 884010 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(884034..885017) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" /label="yfhP CDS" gene complement(884034..885017) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /label="yfhP gene" downshifts complement(884068) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 884491..884500 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 884513..884532 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 884517 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(885018..885165) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 885122..885126 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 885142..885161 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 885149 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 885155..885232 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(885163..885182) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(885165) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(885197..885204) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 885233..886342 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" /label="mutY CDS" gene 885233..886342 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /label="mutY gene" promotor_-35 886179..886183 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 886199..886218 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 886211 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 886343..886655 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(886350..886574) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" /label="yfhS CDS" gene complement(886350..886574) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /label="yfhS gene" promotor_-10 complement(886604..886615) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(886606) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(886629..886635) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 886656..887408 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" /label="fabL CDS" gene 886656..887408 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /label="fabL gene" promotor_-35 887425..887431 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 887446..887457 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 887447 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(887454..887468) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(887475) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(887477..887481) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 887477..887731 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" /label="sspE CDS" gene 887477..887731 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /label="sspE gene" downshifts 887729 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(887754) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" /label="downshifts" CDS 887820..888164 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" /label="ygaB CDS" gene 887820..888164 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /label="ygaB gene" promotor_-35 887827..887835 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 887846..887864 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 887848 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="upshifts" downshifts 888147 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 888203..888210 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 888224..888243 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 888233..888307 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 888233 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="upshifts" CDS 888308..888838 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" /label="ygaC CDS" gene 888308..888838 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /label="ygaC gene" downshifts 888829 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 888926..890668 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" /label="ygaD CDS" gene 888926..890668 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /label="ygaD gene" downshifts 890655 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(890745..891806) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" /label="ygaE CDS" gene complement(890745..891806) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /label="ygaE gene" downshifts complement(890756) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature complement(891807..891897) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(891895..891914) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(891904) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(891929..891936) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(892026..893315) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" /label="gsaB CDS" gene complement(892026..893315) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /label="gsaB gene" downshifts complement(892029) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(893343..893362) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(893362) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(893364..894075) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(893374..893379) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 893408..893415 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 893429..893448 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 893429 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="upshifts" CDS 893468..893941 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" /label="bcp CDS" gene 893468..893941 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /label="bcp gene" promotor_-35 893978..893985 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 894000..894019 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 894006 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="upshifts" CDS 894064..894501 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" /label="perR CDS" gene 894064..894501 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /label="perR gene" downshifts 894483 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(894536..894889) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" /label="ygzB CDS" gene complement(894536..894889) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /label="ygzB gene" downshifts 894549 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(894559) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 894885..894889 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 894897..894911 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(894901..894920) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 894901..894992 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 894901 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="upshifts" upshifts complement(894911) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 894969..894972 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 894987..895006 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 894994..895096 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 894994 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="upshifts" CDS 895097..895981 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" /label="ygxA CDS" gene 895097..895981 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /label="ygxA gene" promotor_-35 895964..895971 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 895985..896004 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 896000..896272 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 896000 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(896033) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" rRNA 896273..897827 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-16S rRNA" gene 896273..897827 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /label="rrnD-16S gene" rRNA 897995..900922 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-23S rRNA" gene 897995..900922 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /label="rrnD-23S gene" S_feature 900923..901008 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 900984..900991 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 901005..901024 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 901010 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="upshifts" rRNA 901034..901149 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-5S rRNA" gene 901034..901149 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /label="rrnD-5S gene" tRNA 901159..901233 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="asnTA tRNA" gene 901159..901233 /gene="asnTA" /locus_tag="BSU_tRNA_29" /label="asnTA gene" tRNA 901239..901330 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Ser tRNA" gene 901239..901330 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /label="trnD-Ser gene" downshifts 901326 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" tRNA 901365..901436 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Glu tRNA" gene 901365..901436 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /label="trnD-Glu gene" tRNA 901446..901521 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Val tRNA" gene 901446..901521 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /label="trnD-Val gene" tRNA 901531..901607 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Met tRNA" gene 901531..901607 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /label="trnD-Met gene" tRNA 901619..901695 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Asp tRNA" gene 901619..901695 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /label="trnD-Asp gene" tRNA 901708..901783 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Phe tRNA" gene 901708..901783 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /label="trnD-Phe gene" tRNA 901789..901861 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Thr tRNA" gene 901789..901861 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /label="trnD-Thr gene" tRNA 901884..901968 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Tyr tRNA" gene 901884..901968 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /label="trnD-Tyr gene" tRNA 901974..902047 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Trp tRNA" gene 901974..902047 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /label="trnD-Trp gene" tRNA 902072..902147 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-His tRNA" gene 902072..902147 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /label="trnD-His gene" tRNA 902157..902228 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Gln tRNA" gene 902157..902228 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /label="trnD-Gln gene" tRNA 902278..902352 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="glyTB tRNA" gene 902278..902352 /gene="glyTB" /locus_tag="BSU_tRNA_41" /label="glyTB gene" tRNA 902358..902428 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="cysTA tRNA" gene 902358..902428 /gene="cysTA" /locus_tag="BSU_tRNA_42" /label="cysTA gene" tRNA 902436..902524 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTA tRNA" gene 902436..902524 /gene="leuTA" /locus_tag="BSU_tRNA_43" /label="leuTA gene" S_feature 902525..902601 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 902558 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature 902603..902771 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 902728..902735 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 902734 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 902749..902768 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 902773 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="upshifts" tRNA 902790..902871 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTB tRNA" gene 902790..902871 /gene="leuTB" /locus_tag="BSU_tRNA_44" /label="leuTB gene" promotor_-10 complement(902807..902824) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(902810) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(902845..902850) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(902880) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" /label="downshifts" CDS complement(902950..903726) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" /label="spo0M CDS" gene complement(902950..903726) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /label="spo0M gene" downshifts complement(902964) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(903753..903768) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(903775) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(903781..903790) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 903810..903816 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 903831..903842 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 903834 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="upshifts" CDS 903868..904071 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" /label="ygzA CDS" gene 903868..904071 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /label="ygzA gene" downshifts 904054 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(904130) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(904156..904428) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" /label="ygzC CDS" gene complement(904156..904428) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /label="ygzC gene" promotor_-10 complement(904387..904405) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(904394) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 904409..904416 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(904422..904427) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 904429..904448 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 904437 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="upshifts" CDS 904470..905162 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" /label="ygaJ CDS" gene 904470..905162 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /label="ygaJ gene" promotor_-35 905191..905195 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(905194..905213) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(905206) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 905209..905228 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(905228..905235) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 905232..905339 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswD RNA" gene 905232..905339 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /label="tswD gene" upshifts 905239 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="upshifts" downshifts 905370 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" /label="downshifts" CDS 905472..907244 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" /label="thiC CDS" gene 905472..907244 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /label="thiC gene" downshifts 907220 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature 907265..908190 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(907282..908637) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" /label="ygaK CDS" gene complement(907282..908637) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /label="ygaK gene" promotor_-10 complement(908665..908684) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(908682) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(908698..908707) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 908755..908761 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 908776..908795 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 908804 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="upshifts" CDS 908888..909085 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" /label="senS CDS" gene 908888..909085 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /label="senS gene" CDS complement(909112..910563) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" /label="katA CDS" gene complement(909112..910563) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /label="katA gene" downshifts complement(909122) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 910540..910546 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 910561..910580 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 910564 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(910581..910600) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 910586..910915 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(910600) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(910614..910621) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(910659..910677) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(910684) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" downshifts 910872 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" CDS 910971..911738 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" /label="ssuB CDS" gene 910971..911738 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /label="ssuB gene" CDS 911756..912754 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" /label="ssuA CDS" gene 911756..912754 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /label="ssuA gene" CDS 912751..913581 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" /label="ssuC CDS" gene 912751..913581 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /label="ssuC gene" CDS 913604..914734 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" /label="ssuD CDS" gene 913604..914734 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /label="ssuD gene" misc_feature 914761..914780 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 914767 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="upshifts" CDS 914838..915374 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" /label="ygaN CDS" gene 914838..915374 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /label="ygaN gene" S_feature 915375..915445 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 915415..915422 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 915436..915455 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 915447 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="upshifts" CDS 915486..915755 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" /label="rpsNB CDS" gene 915486..915755 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /label="rpsNB gene" promotor_-35 915558..915562 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 915585..915601 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 915601 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 915742 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(915773..916246) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" /label="ygaO CDS" gene complement(915773..916246) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /label="ygaO gene" downshifts complement(915809) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(916248..916448) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" /label="ygzD CDS" gene complement(916248..916448) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /label="ygzD gene" promotor_-10 complement(916477..916496) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(916491) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(916509..916516) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 916572..916577 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 916591..916610 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 916591 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="upshifts" tRNA 916642..916715 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gly1 tRNA" gene 916642..916715 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /label="trnSL-Gly1 gene" S_feature 916716..916898 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(916806..917429) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" /label="yhzB CDS" gene complement(916806..917429) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /label="yhzB gene" downshifts complement(916821) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 916855 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature 916900..917511 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(917453..917472) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(917474) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(917486..917493) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 917512..918672 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" /label="queG CDS" gene 917512..918672 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /label="queG gene" downshifts 918681 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 918698..918710 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 918703 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="upshifts" CDS 918739..919674 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" /label="yhbB CDS" gene 918739..919674 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /label="yhbB gene" downshifts complement(918757) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" /label="downshifts" promotor_-35 919658..919661 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 919676 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 919677..919696 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 919712..920194 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" /label="trmL CDS" gene 919712..920194 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /label="trmL gene" downshifts 920177 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 920244..920960 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" /label="yhbD CDS" gene 920244..920960 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /label="yhbD gene" promotor_-35 920264..920271 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 920286..920305 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 920287 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="upshifts" CDS 920951..921664 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" /label="yhbE CDS" gene 920951..921664 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /label="yhbE gene" CDS 921676..922383 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" /label="yhbF CDS" gene 921676..922383 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /label="yhbF gene" downshifts 922267 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 922311 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 922377 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(922410..922585) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(922453) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(922577..922596) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(922585) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(922611..922618) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 922650..922655 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 922671..922689 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 922671 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 922733..924628 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" /label="prkA CDS" gene 922733..924628 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /label="prkA gene" promotor_no_box 923175..923275 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 923235 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 923301 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 924621 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 924685..924690 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 924706..924724 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 924709..924807 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 924709 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 924808..925986 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" /label="yhbH CDS" gene 924808..925986 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /label="yhbH gene" promotor_-35 925006..925009 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 925024..925043 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 925028 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(925269) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" /label="downshifts" downshifts 925965 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 926073..926080 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926095..926114 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926095 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 926146..926610 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" /label="yhbI CDS" gene 926146..926610 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /label="yhbI gene" promotor_-35 926435..926441 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926456..926474 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926469 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 926619..926625 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926639..926650 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926645 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 926646..927311 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" /label="yhbJ CDS" gene 926646..927311 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /label="yhbJ gene" CDS 927352..928950 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" /label="yhcA CDS" gene 927352..928950 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /label="yhcA gene" CDS 928973..929503 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" /label="yhcB CDS" gene 928973..929503 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /label="yhcB gene" CDS 929516..929890 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" /label="yhcC CDS" gene 929516..929890 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /label="yhcC gene" downshifts 929879 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 929890..930045 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" /label="yhcD CDS" gene 929890..930045 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /label="yhcD gene" promotor_-35 929980..929986 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 930001..930020 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 930011 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="upshifts" CDS 930050..930811 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" /label="yhcE CDS" gene 930050..930811 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /label="yhcE gene" promotor_-10 complement(930363..930381) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(930377) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(930397..930402) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 930814..931179 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" /label="yhcF CDS" gene 930814..931179 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /label="yhcF gene" CDS 931181..931879 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" /label="yhcG CDS" gene 931181..931879 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /label="yhcG gene" CDS 931896..932813 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" /label="yhcH CDS" gene 931896..932813 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /label="yhcH gene" CDS 932806..933747 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" /label="yhcI CDS" gene 932806..933747 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /label="yhcI gene" downshifts 933729 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(933839..934042) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" /label="cspB CDS" gene complement(933839..934042) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /label="cspB gene" downshifts complement(933853) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" /label="downshifts" S_feature complement(934043..934170) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 934130..934141 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 934147 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(934159..934178) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(934170) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(934172..935310) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(934192..934197) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 934337..934344 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 934359..934377 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 934366 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 934367..934477 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 934478..935308 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" /label="yhcJ CDS" gene 934478..935308 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /label="yhcJ gene" downshifts 935267 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(935311..936390) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" /label="dgcK CDS" gene complement(935311..936390) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /label="dgcK gene" promotor_-10 complement(936400..936419) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(936421) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="upshifts" promotor_-35 complement(936435..936439) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 936497..936504 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 936518..936537 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 936524 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="upshifts" CDS 936563..937954 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" /label="tcyP CDS" gene 936563..937954 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /label="tcyP gene" S_feature complement(937590..937993) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 937933 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(937994..938449) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" /label="yhcM CDS" gene complement(937994..938449) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /label="yhcM gene" promotor_-10 complement(938464..938482) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(938492) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(938497..938503) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 938541..938547 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 938561..938572 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 938565 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="upshifts" CDS 938599..939168 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" /label="yhcN CDS" gene 938599..939168 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /label="yhcN gene" promotor_-35 938795..938801 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 938812 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 938815..938826 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 939143 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-35 939211..939220 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 939234..939253 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 939244 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="upshifts" CDS 939289..940257 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" /label="yhcO CDS" gene 939289..940257 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /label="yhcO gene" downshifts 940133 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(940189..940842) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " /label="yhcQ CDS" gene complement(940189..940842) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /label="yhcQ gene" downshifts complement(940206) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(940873..940884) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(940875) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(940899..940905) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 940914..940922 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 940925..944578 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" /label="mncR CDS" gene 940925..944578 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /label="mncR gene" promotor_-10 940933..940951 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 940948 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="upshifts" CDS 944575..945171 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" /label="srtA CDS" gene 944575..945171 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /label="srtA gene" downshifts 945150 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(945201..946109) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" /label="yhcT CDS" gene complement(945201..946109) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /label="yhcT gene" promotor_-35 946165..946173 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(946166..946177) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(946172) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(946174..946660) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 946184 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 946187..946206 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(946191..946197) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 946220..946615 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" /label="yhcU CDS" gene 946220..946615 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /label="yhcU gene" misc_feature complement(946646..946665) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(946660) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 946700..946706 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 946715 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 946720..946731 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(946730..946744) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(946744) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(946752..946756) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 946752..947174 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" /label="yhcV CDS" gene 946752..947174 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /label="yhcV gene" promotor_no_box complement(947078..947178) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(947118) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 947152 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(947184) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" promotor_-35 947224..947231 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 947245..947264 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 947253 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="upshifts" CDS 947301..947963 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" /label="glpW CDS" gene 947301..947963 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /label="glpW gene" CDS 947979..949520 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" /label="yhcX CDS" gene 947979..949520 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /label="yhcX gene" downshifts 949503 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" /label="downshifts" CDS 949604..949795 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" /label="yhzG CDS" gene 949604..949795 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo /label="yhzG gene" promotor_-35 949826..949833 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 949848..949867 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 949859..949940 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 949859 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="upshifts" CDS 949941..951293 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" /label="yhxA CDS" gene 949941..951293 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /label="yhxA gene" CDS 951321..951899 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" /label="glpP CDS" gene 951321..951899 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /label="glpP gene" promotor_-35 951894..951901 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 951916..951935 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 951927 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" downshifts 951942 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" /label="downshifts" S_feature 951987..952077 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 952078..952902 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" /label="glpF CDS" gene 952078..952902 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /label="glpF gene" CDS 952921..954411 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" /label="glpK CDS" gene 952921..954411 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /label="glpK gene" promotor_-35 953722..953728 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 953743..953762 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 953753 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="upshifts" S_feature 954412..954500 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 954457 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 954463..954563 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 954523 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" CDS 954552..956219 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" /label="glpD CDS" gene 954552..956219 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /label="glpD gene" promotor_-35 955981..955986 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 956001..956019 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 956010 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="upshifts" promotor_-35 956064..956070 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 956085 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 956086..956104 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 956187 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" /label="downshifts" S_feature 956232..956305 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 956287..956294 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 956307 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 956308..956327 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 956351..958096 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" /label="pgcA CDS" gene 956351..958096 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /label="pgcA gene" downshifts 958085 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" S_feature 958130..958199 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 958201..958220 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 958201 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" CDS 958245..959384 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" /label="yhcY CDS" gene 958245..959384 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /label="yhcY gene" CDS 959381..960025 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" /label="yhcZ CDS" gene 959381..960025 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /label="yhcZ gene" CDS 960022..960546 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" /label="azr CDS" gene 960022..960546 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /label="azr gene" downshifts 960511 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(960561..960803) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" /label="yhdB CDS" gene complement(960561..960803) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /label="yhdB gene" downshifts complement(960582) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(960839..960850) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(960850) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(960864..960871) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 960938..960944 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 960958..960969 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 960968 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="upshifts" CDS 961004..961327 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" /label="yhdC CDS" gene 961004..961327 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /label="yhdC gene" S_feature 961328..963194 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(961369..962835) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" /label="lytF CDS" gene complement(961369..962835) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /label="lytF gene" downshifts complement(961381) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(961468) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(962875..962893) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(962887) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(962907..962914) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(962988..963428) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" /label="nsrR CDS" gene complement(962988..963428) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /label="nsrR gene" downshifts complement(963018) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" promotor_-35 963416..963422 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 963436..963447 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 963438..963548 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 963438 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(963450..963469) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(963466) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(963481..963487) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 963507 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(963535..965193) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" /label="ygxB CDS" gene complement(963535..965193) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /label="ygxB gene" downshifts complement(963540) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(965084..965102) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(965104) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(965116..965122) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 965165..965170 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 965186..965204 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 965199 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="upshifts" CDS 965224..966630 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" /label="spoVR CDS" gene 965224..966630 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /label="spoVR gene" downshifts 966610 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(966660..968045) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" /label="phoA CDS" gene complement(966660..968045) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /label="phoA gene" downshifts complement(966686) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(968072) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(968074..969605) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(968082..968093) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 968201..968208 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 968221..968240 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 968227..968514 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 968227 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 968477..968480 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 968495..968514 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 968516 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="upshifts" CDS 968575..969579 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" /label="lytE CDS" gene 968575..969579 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /label="lytE gene" downshifts 969441 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 969571 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" upshifts complement(969605) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(969612..969627) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 969617 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(969639..969648) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(969650..970525) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" /label="citR CDS" gene complement(969650..970525) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /label="citR gene" promotor_-35 970578..970579 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(970591..970610) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 970596..970615 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(970597) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="upshifts" upshifts 970606 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(970625..970630) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 970634..971734 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" /label="citA CDS" gene 970634..971734 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /label="citA gene" promotor_-35 971745..971751 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 971766..971784 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 971771 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 971808..972677 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" /label="yhdF CDS" gene 971808..972677 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /label="yhdF gene" downshifts 972685 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 972762..972765 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 972777 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 972780..972799 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 972825..972844 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 972830..972926 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 972830 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" CDS 972927..974324 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" /label="bcaP CDS" gene 972927..974324 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /label="bcaP gene" downshifts 974304 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 974385..974389 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 974405..974424 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 974412 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 974442..975797 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" /label="yhdH CDS" gene 974442..975797 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /label="yhdH gene" downshifts 975778 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(975832..977241) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" /label="yhdI CDS" gene complement(975832..977241) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /label="yhdI gene" promotor_-35 977290..977293 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 977308..977327 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 977310 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(977312..977331) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(977324) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(977347..977351) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 977351..977779 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" /label="yhdJ CDS" gene 977351..977779 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /label="yhdJ gene" downshifts 977758 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(977810..978100) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" /label="asiMB CDS" gene complement(977810..978100) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /label="asiMB gene" downshifts complement(977834) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(978088..979164) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" /label="asiMA CDS" gene complement(978088..979164) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /label="asiMA gene" CDS complement(979154..979645) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" /label="sigM CDS" gene complement(979154..979645) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /label="sigM gene" S_feature complement(979646..979748) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(979737..979756) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(979748) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(979770..979773) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 979786..979792 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 979803 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 979807..979825 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(979836) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS 979842..980837 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" /label="akrN CDS" gene 979842..980837 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /label="akrN gene" downshifts 980816 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 980899..980902 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 980917..980936 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 980922 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="upshifts" CDS 980972..981571 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" /label="plsC CDS" gene 980972..981571 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /label="plsC gene" downshifts 981586 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 981631..983585 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(981640..982974) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" /label="yhdP CDS" gene complement(981640..982974) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /label="yhdP gene" downshifts complement(981659) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" CDS complement(983035..983466) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" /label="cueR CDS" gene complement(983035..983466) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /label="cueR gene" promotor_-10 complement(983478..983497) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(983488) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(983512..983518) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(983514..983614) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 983549..983556 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(983554) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 983570..983589 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 983587 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="upshifts" CDS 983623..984804 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" /label="yhdR CDS" gene 983623..984804 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /label="yhdR gene" downshifts 984789 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" /label="downshifts" S_feature 984834..984972 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 984968..984987 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 984974..985130 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 984974 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="upshifts" CDS 985131..986516 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" /label="yhdT CDS" gene 985131..986516 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /label="yhdT gene" downshifts 986406 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 986492 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(986530..986886) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" /label="crcBA CDS" gene complement(986530..986886) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /label="crcBA gene" CDS complement(986883..987278) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" /label="crcBB CDS" gene complement(986883..987278) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /label="crcBB gene" CDS complement(987265..987996) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" /label="yhdW CDS" gene complement(987265..987996) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /label="yhdW gene" misc_feature complement(988021..988040) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(988042) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 988089..988097 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 988106 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 988111..988126 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 988120..988193 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 988180..988181 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 988195 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 988197..988216 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 988230..988337 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" /label="yhdX CDS" gene 988230..988337 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /label="yhdX gene" S_feature 988338..988391 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 988362 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 988442..988461 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 988448 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 988486..989601 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" /label="mscY CDS" gene 988486..989601 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /label="mscY gene" downshifts 989581 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" /label="downshifts" misc_feature 989638..989657 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 989638 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 989671..990414 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" /label="srtN CDS" gene 989671..990414 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /label="srtN gene" downshifts 990386 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(990438..991286) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" /label="yheN CDS" gene complement(990438..991286) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /label="yheN gene" downshifts complement(990462) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 991282..991287 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(991287..991386) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 991303..991321 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 991305 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="upshifts" S_feature 991310..991505 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(991375..991394) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(991389) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(991409..991412) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 991504..991523 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 991507..991570 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 991507 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="upshifts" CDS 991571..992419 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" /label="dat CDS" gene 991571..992419 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /label="dat gene" downshifts 992410 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(992462..993823) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" /label="nhaC CDS" gene complement(992462..993823) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /label="nhaC gene" downshifts complement(992486) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(993824..993894) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(993867..993886) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(993894) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(993950..994450) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" /label="nhaX CDS" gene complement(993950..994450) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /label="nhaX gene" downshifts complement(993982) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(994472..994490) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(994492) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(994505..994511) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 994529..994536 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 994544..994613 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 994545 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 994551..994570 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 994614..994775 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" /label="bmrB CDS" gene 994614..994775 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /label="bmrB gene" downshifts 994705 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" /label="downshifts" S_feature 994776..994894 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 994895..996652 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" /label="bmrC CDS" gene 994895..996652 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /label="bmrC gene" CDS 996649..998670 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" /label="bmrD CDS" gene 996649..998670 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /label="bmrD gene" downshifts 998658 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(998719..999339) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" /label="yheG CDS" gene complement(998719..999339) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /label="yheG gene" downshifts complement(998734) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 999324..999424 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(999353..999372) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(999368) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="upshifts" CDS complement(999378..999503) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" /label="yheF CDS" gene complement(999378..999503) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /label="yheF gene" upshifts 999384 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(999387..999390) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(999517..999536) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(999526) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(999550..999559) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 999582 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(999608..999811) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" /label="sspB CDS" gene complement(999608..999811) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /label="sspB gene" downshifts complement(999613) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(999812..999922) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 999852..999952 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 999912 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(999928) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(999932..999943) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(999958..999964) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1000020..1000238) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" /label="yheE CDS" gene complement(1000020..1000238) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /label="yheE gene" downshifts complement(1000054) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1000279..1000298) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1000296) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1000312..1000319) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1000388..1001749) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" /label="spaD CDS" gene complement(1000388..1001749) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /label="spaD gene" downshifts complement(1000406) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1000450) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1001739..1002830) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" /label="spaC CDS" gene complement(1001739..1002830) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /label="spaC gene" promotor_-10 complement(1002154..1002168) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1002166) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1002182..1002190) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1002831..1002936) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(1002920..1002938) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1002940) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1002954..1002959) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1003002..1003009 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1003024..1003043 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1003035 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="upshifts" CDS 1003097..1004230 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" /label="yheB CDS" gene 1003097..1004230 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /label="yheB gene" S_feature 1004231..1004322 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 1004323..1004676 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" /label="yheA CDS" gene 1004323..1004676 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /label="yheA gene" downshifts 1004664 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1004720..1005793) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" /label="yhaZ CDS" gene complement(1004720..1005793) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /label="yhaZ gene" downshifts complement(1004827) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1005815..1005834) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1005827) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1005848..1005855) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1005930..1005937 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1005950 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1005952..1005971 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1005961..1006114 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 1006071 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 1006116..1006199 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 1006156 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" /label="downshifts" promotor_-35 1006212..1006217 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1006233..1006251 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1006242 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1006279..1007145 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" /label="yhaX CDS" gene 1006279..1007145 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /label="yhaX gene" downshifts 1007127 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1007190..1007193 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1007208..1007227 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1007216 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1007257..1008762 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" /label="hemZ CDS" gene 1007257..1008762 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /label="hemZ gene" downshifts 1008732 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1008780..1009997) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" /label="khtU CDS" gene complement(1008780..1009997) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /label="khtU gene" downshifts complement(1008786) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1010004..1010501) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" /label="khtT CDS" gene complement(1010004..1010501) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /label="khtT gene" CDS complement(1010565..1010903) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" /label="khtS CDS" gene complement(1010565..1010903) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /label="khtS gene" promotor_-10 complement(1010915..1010934) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1010939) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1010948..1010955) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1010975..1010982 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1010997..1011016 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1011007 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="upshifts" CDS 1011068..1011835 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" /label="yhaR CDS" gene 1011068..1011835 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /label="yhaR gene" downshifts 1011836 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1011856..1012041) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" /label="yhzD CDS" gene complement(1011856..1012041) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /label="yhzD gene" promotor_-10 complement(1012077..1012095) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1012088) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1012106..1012114) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1012115..1012118 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1012133..1012152 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1012143 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="upshifts" CDS 1012168..1013064 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" /label="yhaQ CDS" gene 1012168..1013064 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /label="yhaQ gene" CDS 1013057..1014316 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" /label="yhaP CDS" gene 1013057..1014316 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /label="yhaP gene" downshifts 1014300 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1014364..1014371 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1014383..1014402 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1014388 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1014423..1015649 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" /label="yhaO CDS" gene 1014423..1015649 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /label="yhaO gene" downshifts complement(1015124) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" /label="downshifts" CDS 1015654..1018545 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" /label="sbcE CDS" gene 1015654..1018545 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /label="sbcE gene" promotor_-35 1016935..1016940 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1016956..1016974 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1016962 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1018553..1018558 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1018573..1018592 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1018588 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1018619..1019563 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" /label="yhaM CDS" gene 1018619..1019563 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /label="yhaM gene" downshifts 1019541 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 1019622..1019627 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1019643..1019661 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1019646 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="upshifts" CDS 1019688..1019900 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" /label="yhaL CDS" gene 1019688..1019900 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /label="yhaL gene" downshifts 1019893 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" /label="downshifts" downshifts complement(1019931) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(1019941..1020819) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" /label="prsA CDS" gene complement(1019941..1020819) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /label="prsA gene" downshifts complement(1020129) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1020857..1020876) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1020881) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1020890..1020897) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1020917..1020926 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1020938 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1020939..1020958 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1020975..1020989) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1020976) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1020979..1021065 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" /label="sscA CDS" gene 1020979..1021065 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /label="sscA gene" promotor_-35 complement(1020998..1021002) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1021066..1021317 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 1021190..1021276 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" /label="sscB CDS" gene 1021190..1021276 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /label="sscB gene" downshifts 1021274 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" S_feature complement(1021286..1021548) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 1021319..1021802 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(1021329) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1021541..1021560) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1021548) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1021550..1021618) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(1021574..1021579) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1021619..1022137) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" /label="yhaJ CDS" gene complement(1021619..1022137) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /label="yhaJ gene" promotor_-35 1021924..1021932 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1021944..1021962 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1021957 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1022168..1022187) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1022186) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1022203..1022209) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1022286..1022289 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1022304..1022323 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1022309 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="upshifts" CDS 1022345..1022686 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" /label="yhaI CDS" gene 1022345..1022686 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /label="yhaI gene" S_feature complement(1022540..1022682) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(1022583) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1022683..1023294) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" /label="scoC CDS" gene complement(1022683..1023294) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /label="scoC gene" S_feature 1022687..1023452 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(1022759) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" promotor_-35 1023290..1023294 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1023302..1023315 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1023314 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1023319..1023338) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(1023342) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="upshifts" promotor_-35 complement(1023353..1023356) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 1023409 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1023472..1023828) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" /label="yhaH CDS" gene complement(1023472..1023828) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /label="yhaH gene" downshifts complement(1023476) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1023905..1023910 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1023911..1023930) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1023925) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1023926..1023944 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1023926 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1023927..1024190) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 1023958..1024149 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" /label="yhzF CDS" gene 1023958..1024149 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /label="yhzF gene" S_feature 1024150..1025585 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(1024223..1024741) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" /label="trpP CDS" gene complement(1024223..1024741) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /label="trpP gene" downshifts complement(1024235) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" /label="downshifts" S_feature complement(1024742..1024829) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(1024821..1024840) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1024829) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1024854..1024861) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1024866..1025945) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" /label="serC CDS" gene complement(1024866..1025945) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /label="serC gene" misc_feature complement(1025984..1026003) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1025995) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1025997..1026078) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(1026092..1026529) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" /label="hinT CDS" gene complement(1026092..1026529) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /label="hinT gene" downshifts complement(1026123) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1026562..1026581) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1026576) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" downshifts 1026579 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(1026595..1026602) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1026601..1026897) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(1026644) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1026895..1026906) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1026901) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1026921..1026927) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1026957..1026964 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1026978..1026997 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1026987 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="upshifts" CDS 1027017..1027760 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" /label="ecsA CDS" gene 1027017..1027760 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /label="ecsA gene" CDS 1027753..1028979 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" /label="ecsB CDS" gene 1027753..1028979 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /label="ecsB gene" promotor_-10 complement(1028312..1028330) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1028327) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1028346..1028351) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1028999..1029709 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" /label="ecsC CDS" gene 1028999..1029709 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /label="ecsC gene" downshifts 1029673 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1029727..1030917) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" /label="sndC CDS" gene complement(1029727..1030917) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /label="sndC gene" downshifts complement(1029737) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1029802) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1030941..1030960) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1030962) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1030974..1030979) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1030990..1032381) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" /label="yhfA CDS" gene complement(1030990..1032381) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /label="yhfA gene" promotor_-10 complement(1032392..1032411) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1032397) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1032424..1032433) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1032447..1032761) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" /label="yhgB CDS" gene complement(1032447..1032761) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /label="yhgB gene" CDS complement(1032806..1033306) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" /label="hmoB CDS" gene complement(1032806..1033306) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /label="hmoB gene" downshifts complement(1032833) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1033319..1033338) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1033321..1033325 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1033340) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1033341..1033360 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1033342 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1033355..1033356) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1033373..1033379 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1033394..1033405 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1033399 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="upshifts" CDS 1033428..1035572 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" /label="pbpF CDS" gene 1033428..1035572 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /label="pbpF gene" promotor_-10 complement(1033472..1033483) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1033475) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1033497..1033503) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1035609..1035615 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1035629..1035648 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1035639 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" CDS 1035694..1036755 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" /label="hemE CDS" gene 1035694..1036755 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /label="hemE gene" CDS 1036827..1037759 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" /label="hemH CDS" gene 1036827..1037759 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /label="hemH gene" CDS 1037774..1039186 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" /label="hemY CDS" gene 1037774..1039186 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /label="hemY gene" downshifts 1037777 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1039163 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1039247..1039254 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1039268..1039287 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1039273 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" CDS 1039332..1039907 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" /label="yhgD CDS" gene 1039332..1039907 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /label="yhgD gene" promotor_-35 1039651..1039654 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1039669 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1039671..1039690 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1039908..1039977 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 1039978..1042305 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" /label="yhgE CDS" gene 1039978..1042305 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /label="yhgE gene" downshifts 1042287 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1042347..1043324) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" /label="fabHB CDS" gene complement(1042347..1043324) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /label="fabHB gene" downshifts complement(1042360) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1043338..1043357) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1043356) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1043371..1043377) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1043383..1043391 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1043402..1043420 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1043409 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 1043451..1044227 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" /label="yhfC CDS" gene 1043451..1044227 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /label="yhfC gene" S_feature complement(1043943..1044564) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 1044228..1044599 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(1044542..1044561) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1044563) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1044575..1044584) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1044577..1044584 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1044599..1044618 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1044601 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 1044640..1045680 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" /label="yhfE CDS" gene 1044640..1045680 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /label="yhfE gene" CDS 1045693..1046100 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" /label="yhfF CDS" gene 1045693..1046100 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /label="yhfF gene" downshifts 1046071 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(1046137..1047426) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" /label="gltT CDS" gene complement(1046137..1047426) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /label="gltT gene" downshifts complement(1046167) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(1047427..1047527) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(1047526..1047545) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1047527) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1047529..1047665) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(1047560..1047566) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1047697..1047837) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" /label="yhfH CDS" gene complement(1047697..1047837) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /label="yhfH gene" downshifts complement(1047710) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1047856..1047875) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1047875) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1047888..1047895) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1047919..1047925 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1047939..1047958 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1047942 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="upshifts" CDS 1047989..1048723 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" /label="yhfI CDS" gene 1047989..1048723 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /label="yhfI gene" CDS 1048736..1049731 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" /label="lplJ CDS" gene 1048736..1049731 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /label="lplJ gene" CDS 1049796..1050440 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" /label="yhfK CDS" gene 1049796..1050440 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /label="yhfK gene" downshifts 1050428 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1050468..1050471 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1050486..1050505 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1050493 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="upshifts" CDS 1050557..1052098 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" /label="lcfB CDS" gene 1050557..1052098 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /label="lcfB gene" downshifts 1052078 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1052137..1052532) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" /label="yhfM CDS" gene complement(1052137..1052532) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /label="yhfM gene" downshifts complement(1052154) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1052552..1052563) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1052556) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1052578..1052584) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1052617..1052620 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1052628 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1052635..1052654 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1052681..1053961 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" /label="yhfN CDS" gene 1052681..1053961 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /label="yhfN gene" promotor_-10 complement(1053108..1053127) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1053122) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1053143..1053148) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1053948 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(1053998) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1054000..1055145) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" /label="aprE CDS" gene complement(1054000..1055145) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /label="aprE gene" S_feature complement(1055146..1055212) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1055201..1055220) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1055218) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1055236..1055240) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1055525..1055532 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1055547..1055566 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1055549 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="upshifts" CDS 1055580..1056029 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" /label="yhfO CDS" gene 1055580..1056029 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /label="yhfO gene" promotor_-35 1056045..1056052 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1056067..1056086 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1056074 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1056101..1057093 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" /label="yhfP CDS" gene 1056101..1057093 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /label="yhfP gene" downshifts 1057094 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" S_feature 1057139..1057249 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1057227..1057234 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1057250..1057269 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1057251 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1057310..1058281 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" /label="yhfQ CDS" gene 1057310..1058281 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /label="yhfQ gene" downshifts 1058260 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1058313..1058894) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" /label="phoE CDS" gene complement(1058313..1058894) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /label="phoE gene" downshifts complement(1058336) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1058918..1058937) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1058930) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1058953..1058956) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1058965..1060059) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" /label="yhfS CDS" gene complement(1058965..1060059) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /label="yhfS gene" CDS complement(1060056..1061495) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" /label="yhfT CDS" gene complement(1060056..1061495) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /label="yhfT gene" CDS complement(1061502..1062062) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" /label="bioY CDS" gene complement(1061502..1062062) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /label="bioY gene" misc_feature complement(1061512..1061531) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1061526) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1062087..1062106) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1062101) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1062121..1062128) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1062197..1063495) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" /label="hemAT CDS" gene complement(1062197..1063495) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /label="hemAT gene" downshifts complement(1062208) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1063549..1063567) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1063552) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1063581..1063587) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1063634..1065163) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" /label="yhfW CDS" gene complement(1063634..1065163) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /label="yhfW gene" promotor_-10 complement(1065190..1065208) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1065200) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1065219..1065224 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1065223..1065228) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1065236 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1065240..1065258 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1065275..1066132 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" /label="yhxC CDS" gene 1065275..1066132 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /label="yhxC gene" downshifts 1066114 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1066160..1066393) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" /label="yhzC CDS" gene complement(1066160..1066393) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /label="yhzC gene" downshifts complement(1066193) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1066410..1066429) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1066413..1066414 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1066413 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1066417..1066432 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1066432) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1066434..1067289) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1066444..1066451) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1066616..1066623 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1066635..1066654 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1066641 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="upshifts" CDS 1066686..1067264 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 1066686..1067264 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" S_feature 1067265..1067410 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1067311..1068210) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" /label="yhxD CDS" gene complement(1067311..1068210) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /label="yhxD gene" downshifts complement(1067334) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1067397..1067400 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1067412 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1067418..1067422 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1067456 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1067501..1068367 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1068237..1068255) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1068254) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1068270..1068276) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1068344..1068351 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1068366..1068385 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1068369 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1068427..1068696 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" /label="yhjA CDS" gene 1068427..1068696 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /label="yhjA gene" downshifts 1068688 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1068736) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1068739..1070208) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" /label="yhjB CDS" gene complement(1068739..1070208) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /label="yhjB gene" CDS complement(1070205..1070405) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" /label="yhjC CDS" gene complement(1070205..1070405) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /label="yhjC gene" S_feature complement(1070406..1070524) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1070507..1070526) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1070524) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1070539..1070546) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1070612) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1070613..1070975) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" /label="yhjD CDS" gene complement(1070613..1070975) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /label="yhjD gene" promotor_-35 1070813..1070818 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1070834..1070852 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1070835 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1070844..1071083 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1071005..1071024) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1071023) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1071039..1071046) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1071065..1071072 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1071085 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1071086..1071105 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1071127..1071750 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" /label="yhjE CDS" gene 1071127..1071750 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /label="yhjE gene" CDS 1071752..1072258 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" /label="sipV CDS" gene 1071752..1072258 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /label="sipV gene" downshifts 1072251 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1072309..1072316 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1072330..1072349 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1072339..1072438 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1072339 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="upshifts" CDS 1072439..1073938 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" /label="yhjG CDS" gene 1072439..1073938 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /label="yhjG gene" promotor_-35 1073946..1073953 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1073965 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1073967..1073986 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1074015..1074542 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" /label="yhjH CDS" gene 1074015..1074542 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /label="yhjH gene" downshifts 1074504 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" /label="downshifts" S_feature complement(1074556..1074699) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" downshifts complement(1074594) /Source="Nicolas_upshifts" /id="D575" /incds=0 /nref=4 /ntot=72 /MaxReadThrough="1.20458" /MaxDrop="5.06167" /score="27.254423" /energy="-9.9" /TU="NA" /idTUdmin="U855" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1074700..1075905) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9457850, 15849754, 16850406, 17056753, 19087206" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457850, 15849754, 16850406, 17056753, 19087206; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose/mannose:H+ symporter (recent HGT island)" /protein_id="NP_388933.1" /db_xref="EnsemblGenomes-Gn:BSU10520" /db_xref="EnsemblGenomes-Tr:CAB12892" /db_xref="GOA:O07563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13075" /db_xref="UniProtKB/Swiss-Prot:O07563" /translation="MLRGTYLFGYAFFFTVGIIHISTGSLTPFLLEAFNKTTDDISVI IFFQFTGFLSGVLIAPLMIKKYSHFRTLTLALTIMLVALSIFFLTKDWYYIIVMAFLL GYGAGTLETTVGSFVIANFESNAEKMSKLEVLFGLGALSFPLLINSFIDINNWFLPYY CIFTFLFVLFVGWLIFLSKNREYAKNANQQVTFPDGGAFQYFIGDRKKSKQLGFFVFF AFLYAGIETNFANFLPSIMINQDNEQISLISVSFFWVGIIIGRILIGFVSRRLDFSKY LLFSCSCLIVLLIAFSYISNPILQLSGTFLIGLSIAGIFPIALTLASIIIQKYVDEVT SLFIASASFGGAIISFLIGWSLNQDTILLTMGIFTTMAVILVGISVKIRRTKTEDPIS LENKASKTQ*" /label="glcP CDS" gene complement(1074700..1075905) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" /label="glcP gene" promotor_-35 1075395..1075400 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1075417..1075435 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1075420..1075946 /Source="Nicolas_S_feature" /locus_tag="new_1125843_1126369" /HighExp="S4, S5, S6, S8, S7, S3, T5.0H, M9-stat, LBGstat, T4.0H" /AntisenseName="glcP" /AntisenseCor="-0.155079396671681" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S372" upshifts 1075421 /Source="Nicolas_upshifts" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="upshifts" downshifts 1075904 /Source="Nicolas_upshifts" /id="D576" /incds=0 /nref=6 /ntot=59 /MaxReadThrough="2.40974" /MaxDrop="3.26024" /score="9.68585629" /energy="-9.4" /TU="NA" /idTUdmin="U852" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1075977..1077029) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" /EC_number="1.1.1.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose), glucose-6-P 3-dehydrogenase; kanosamine biosynthesis (recent HGT island)" /protein_id="NP_388934.2" /db_xref="EnsemblGenomes-Gn:BSU10530" /db_xref="EnsemblGenomes-Tr:CAB12893" /db_xref="GOA:O07564" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13076" /db_xref="UniProtKB/Swiss-Prot:O07564" /translation="MKKIGIIGAGGIARAHATALSTIKNAELVGVYDINQQNAESFVK TFGGKSFENVDELIDASEGLIVASPNFCHKEHALQALGKHKHVLCEKPMAISLEEASI MKDTAERLSVRASMGFNYRYLSYVNILKSLIINNELGNILSIKVHFKKNSALRRKKFT WRDDANSKKTSGSLGDLGIHLIDMVWYLFESDFITESVRAKMNTNVKTKEDKQVLVDD YAEIYGQLKNKVFVNIITSKCSVPEDCGFSIEVVGHKKEFKYHTGNPHVYKLIDGLNV VDCPVPQSLLNDPPNEFYGWADSFRSELINWIASTQNDWVEIPSFSDGFRSQEVLEMF FEKDSNSQPMSVSAVN*" /label="ntdC CDS" gene complement(1075977..1077029) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" /label="ntdC gene" CDS complement(1077043..1077891) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);kanosamine-6-phosphate phosphatase (recent HGT island)" /protein_id="NP_388935.2" /db_xref="EnsemblGenomes-Gn:BSU10540" /db_xref="EnsemblGenomes-Tr:CAB12894" /db_xref="GOA:O07565" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR006380" /db_xref="InterPro:IPR036412" /db_xref="PDB:3GYG" /db_xref="SubtiList:BG13077" /db_xref="UniProtKB/Swiss-Prot:O07565" /translation="MLLSKKSEYKTLSTVEHPQYIVFCDFDETYFPHTIDEQKQQDIY ELEDYLEQKSKDGELIIGWVTGSSIESILDKMGRGKFRYFPHFIASDLGTEITYFSEH NFGQQDNKWNSRINEGFSKEKVEKLVKQLHENHNILLNPQTQLGKSRYKHNFYYQEQD EINDKKNLLAIEKICEEYGVSVNINRCNPLAGDPEDSYDVDFIPIGTGKNEIVTFMLE KYNLNTERAIAFGDSGNDVRMLQTVGNGYLLKNATQEAKNLHNLITDSEYSKGITNTL KKLIGS*" /label="ntdB CDS" gene complement(1077043..1077891) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" /label="ntdB gene" CDS complement(1077863..1079188) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" /EC_number="2.6.1.-" /function="16.5: Explore" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);3-oxo-glucose-6-phosphate:glutamate aminotransferase; kanosamine aminotransferase (recent HGT island)" /protein_id="NP_388936.1" /db_xref="EnsemblGenomes-Gn:BSU10550" /db_xref="EnsemblGenomes-Tr:CAB12895" /db_xref="GOA:O07566" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:4K2B" /db_xref="PDB:4K2I" /db_xref="PDB:4K2M" /db_xref="SubtiList:BG13078" /db_xref="UniProtKB/Swiss-Prot:O07566" /translation="MQKQVKISGKSKENMSLLKHLKGDVQGKELVIEDSIVNERWKQV LKEKIDIEHDLFNYQKNREISKVPFLPVDRLITNDEVEDILNTLTEVLPTGKFTSGPY LEQFEKVLSTYLHKRYVIATSSGTDAIMIGLLALGLNPGDEVIMPANSFSATENAVLA SGGVPIYVDINPQTFCIDPDKIEEAITPYTKFILPVHLYGKHSDMQHIRQIANRYKLK VIEDACQGIGLTDLGKYADITTLSFNPYKNFGVCGKAGAIATDNEELAKKCIQFSYHG FEVNVKNKKVINFGFNSKMDNLQAAIGLERMKYLSLNNFKRLFLADRYITQLAELQNK GYIELPELSEDHVWHLFPIKVRTEDRADIMTKLNEDFGVQTDVYYPILSHMQKTPLVQ DKYAGLQLVHTEKAHSQVLHLPLYPSFTLEEQDRVMEGLFHVIKQEIGV*" /label="ntdA CDS" gene complement(1077863..1079188) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" /label="ntdA gene" promotor_-35 1078032..1078037 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-35" promotor_-10 1078053..1078071 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-10" S_feature 1078059..1078847 /Source="Nicolas_S_feature" /locus_tag="new_1128482_1129270" /HighExp="S4, S3, S5, S6, S7, T5.0H, M9-stat, S8, Pyr, G/S" /AntisenseName="ntdA" /AntisenseCor="-0.29559566742128002" /AntisenseRegPval="-6.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S373" upshifts 1078059 /Source="Nicolas_upshifts" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="upshifts" promotor_-35 1078823..1078830 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1078845..1078864 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1078849..1079291 /Source="Nicolas_S_feature" /locus_tag="new_1129272_1129714" /HighExp="T4.0H, T3.0H, T2.30H, HiOs, T3.30H, T2.0H, T5.0H, T1.30H, LoTm, T-1.10H" /AntisenseName="ntdA" /AntisenseCor="-0.101471720232752" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.998, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S374" upshifts 1078849 /Source="Nicolas_upshifts" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1079223..1079242) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1079235) /Source="Nicolas_upshifts" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1079256..1079263) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1079292..1080281 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the ntd operon (NtdR-NTD) (recent HGT island)" /protein_id="NP_388937.1" /db_xref="EnsemblGenomes-Gn:BSU10560" /db_xref="EnsemblGenomes-Tr:CAB12896" /db_xref="GOA:O07567" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13079" /db_xref="UniProtKB/Swiss-Prot:O07567" /translation="MPTIDEIAKLCNVSKTTVSRVLNNHPYVSKEKRDMILKAINELD YTPNYLARNFRRNKTQTIALSVPSIDHPFFAQLIKGVSHEVLFKNYKVIVFQTFYDKQ TELELLELLKHKEVDGIILGTLENEWDQISPFLKYGPILLCNEYHHSADITIIGYDEF EAAYMGVVHLIERGHKKIGFCFDTPYSEAQCQRKEGYLKALQDYNLHHRSEWIFGEMF NIEDGFRVFHKIKDLKDRPSAIFTGNDQVAAGIIKQAMKNGFKVPEDLAVIGFDNQLI CQVVTPTITTIDIPVIELGQQAVLKIIESISGNASLNRRIIKLPTKLIIREST*" /label="ntdR CDS" gene 1079292..1080281 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" /label="ntdR gene" S_feature 1080282..1080659 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(1080336..1080494) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1080379) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1080495..1081649) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" /label="yhjN CDS" gene complement(1080495..1081649) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /label="yhjN gene" S_feature complement(1081650..1081721) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1081704..1081723) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1081720) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1081737..1081742) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1081756..1082961) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" /label="yhjO CDS" gene complement(1081756..1082961) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /label="yhjO gene" misc_feature 1082982..1083001 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1082987 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1083075..1084802 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" /label="yhjP CDS" gene 1083075..1084802 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /label="yhjP gene" promotor_-35 1084388..1084395 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1084410..1084429 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1084417 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1084832..1085158) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" /label="yhjQ CDS" gene complement(1084832..1085158) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /label="yhjQ gene" CDS complement(1085276..1085713) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" /label="yhjR CDS" gene complement(1085276..1085713) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /label="yhjR gene" downshifts complement(1085285) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1085744..1085763) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1085764) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1085776..1085785) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1085833..1085840 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1085854..1085873 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1085866 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="upshifts" CDS 1085897..1089397 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" /label="addB CDS" gene 1085897..1089397 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /label="addB gene" CDS 1089384..1093082 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" /label="addA CDS" gene 1089384..1093082 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /label="addA gene" S_feature 1093083..1093153 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1093154..1094329 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " /label="sbcD CDS" gene 1093154..1094329 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /label="sbcD gene" CDS 1094326..1097718 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" /label="sbcC CDS" gene 1094326..1097718 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /label="sbcC gene" promotor_-35 1096973..1096979 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1096994..1097005 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1097001 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1097070..1098043) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1097732..1098034 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" /label="hlpB CDS" gene 1097732..1098034 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /label="hlpB gene" downshifts 1098014 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1098071..1098289) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007, 20161744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007, 20161744; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388948.2" /db_xref="EnsemblGenomes-Gn:BSU10670" /db_xref="EnsemblGenomes-Tr:CAB12907" /db_xref="GOA:O06716" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13090" /db_xref="UniProtKB/Swiss-Prot:O06716" /translation="MPAIVGPIAINSISGGVVNFGDSFYLSPKSSSKSALGSGAGNTG DFLLLNNAVNATNYIDPDVNDQDMVGNG*" /label="gerPF CDS" gene complement(1098071..1098289) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /label="gerPF gene" downshifts complement(1098088) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" /label="downshifts" CDS complement(1098321..1098722) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388949.1" /db_xref="EnsemblGenomes-Gn:BSU10680" /db_xref="EnsemblGenomes-Tr:CAB12908" /db_xref="GOA:O06717" /db_xref="InterPro:IPR024496" /db_xref="SubtiList:BG13091" /db_xref="UniProtKB/Swiss-Prot:O06717" /translation="MLKRISRIRLVKFNSLGIASVFQVGDTNEIDMSVKVFAVQRSLS TFYHNEGSFNKKEYQIFQQQAVKPLPETGVQSAFCHEVPAIYVRSIKIQGVSASSVLH AGSASLIRGDARLKHIRQIQSPRSQSPAKNI*" /label="gerPE CDS" gene complement(1098321..1098722) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /label="gerPE gene" CDS complement(1098722..1098898) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388950.1" /db_xref="EnsemblGenomes-Gn:BSU10690" /db_xref="EnsemblGenomes-Tr:CAB12909" /db_xref="GOA:O06718" /db_xref="InterPro:IPR017257" /db_xref="SubtiList:BG13092" /db_xref="UniProtKB/Swiss-Prot:O06718" /translation="MIFTVINRSLEVGDIRMNGVSSSSVFHIGDTESIYLSSIFDTPP ESLIIGPFAPLAPE*" /label="gerPD CDS" gene complement(1098722..1098898) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /label="gerPD gene" CDS complement(1098895..1099512) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388951.1" /db_xref="EnsemblGenomes-Gn:BSU10700" /db_xref="EnsemblGenomes-Tr:CAB12910" /db_xref="GOA:O06719" /db_xref="InterPro:IPR019673" /db_xref="SubtiList:BG13093" /db_xref="UniProtKB/Swiss-Prot:O06719" /translation="MYDQSVSSYLQNLNSFVQQQAIHIQQLERQLKEIQTEMNTMKQR PATTIERVEYKFDQLKIERLDGTLNIGLNPTDPNSVQNFDVSQSTPQIGMMQQEESAQ LMQQIRQNVDMYLTEEIPDILEQLENQYDSRLDDTNRHHVIEDIRKQMDSRIHYYMSH IKKEENTPPAQYAEHIAEHVKRDVIRAVEHFLEHIPSEMKGDEQA*" /label="gerPC CDS" gene complement(1098895..1099512) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /label="gerPC gene" CDS complement(1099535..1099768) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388952.2" /db_xref="EnsemblGenomes-Gn:BSU10710" /db_xref="EnsemblGenomes-Tr:CAB12911" /db_xref="GOA:O06720" /db_xref="InterPro:IPR024255" /db_xref="SubtiList:BG13094" /db_xref="UniProtKB/Swiss-Prot:O06720" /translation="MNFYINQTIQINYLRLESISNSSILQIGSAGSIKSLSNLYNTGS YVEPAPEVSGSGQPLQLQEPDTGSLVPLQPPGR*" /label="gerPB CDS" gene complement(1099535..1099768) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /label="gerPB gene" CDS complement(1099783..1100004) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388953.1" /db_xref="EnsemblGenomes-Gn:BSU10720" /db_xref="EnsemblGenomes-Tr:CAB12912" /db_xref="GOA:O06721" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13095" /db_xref="UniProtKB/Swiss-Prot:O06721" /translation="MPAIVGAFKINAIGTSGVVHIGDCITISPQAQVRTFAGAGSFNT GDSLKVMNYQNATNVYDNDAVDQPIVANA*" /label="gerPA CDS" gene complement(1099783..1100004) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /label="gerPA gene" S_feature complement(1100005..1100091) /Source="Nicolas_S_feature" /locus_tag="new_1150428_1150514_c" /HighExp="S6, S8, S7, S5, BT, B36, B60, G/S, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S380" promotor_-35 1100019..1100025 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1100039..1100058 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1100041..1100696 /Source="Nicolas_S_feature" /locus_tag="new_1150464_1151119" /HighExp="Salt, BC, Sw, S8, Heat, M9-stat, S7, Etha, BMM, Lbtran" /AntisenseName="yisI" /AntisenseCor="3.97396613023396E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="0.17396" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S381" upshifts 1100041 /Source="Nicolas_upshifts" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1100078..1100097) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1100091) /Source="Nicolas_upshifts" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1100093..1100222) /Source="Nicolas_S_feature" /locus_tag="new_1150516_1150645_c" /HighExp="S6, S8, S7, T5.0H, T3.30H, T4.0H, S5, T3.0H, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S382" promotor_-35 complement(1100110..1100119) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1100224..1100426) /Source="Nicolas_S_feature" /locus_tag="new_1150647_1150849_c" /HighExp="T5.0H, T4.0H, T3.30H, S6, M9-stat, T3.0H, S8, S7, T2.30H, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.976, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S383" downshifts complement(1100267) /Source="Nicolas_upshifts" /id="D581" /incds=0 /nref=13 /ntot=116 /MaxReadThrough="3.97434" /MaxDrop="3.59184" /score="13.5435041" /energy="-15.3" /TU="U865" /idTUdmin="U864" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1100427..1100597) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase (iron-metabolism related)" /protein_id="NP_388954.1" /db_xref="EnsemblGenomes-Gn:BSU10730" /db_xref="EnsemblGenomes-Tr:CAB12913" /db_xref="GOA:O06722" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13096" /db_xref="UniProtKB/Swiss-Prot:O06722" /translation="MNSKIEEMRITLIETAQKYGMNSKETIQCSQELDILLNTRIKEE MIFGRYLENSRM*" /label="pchI CDS" gene complement(1100427..1100597) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /label="pchI gene" misc_feature complement(1100641..1100660) /Source="Nicolas_upshift_promotors" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1100644) /Source="Nicolas_upshifts" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1100646..1100742) /Source="Nicolas_S_feature" /locus_tag="new_1151069_1151165_c" /HighExp="S6, S8, S7, S5, BT, Pyr, G/S, Glucon, SMMPr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S384" downshifts 1100653 /Source="Nicolas_upshifts" /id="D582" /incds=0 /nref=3 /ntot=54 /MaxReadThrough="4.52913" /MaxDrop="3.35342" /score="12.6645711" /energy="-10.3" /TU="U862" /idTUdmin="U862" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 1100698..1100862 /Source="Nicolas_S_feature" /locus_tag="new_1151121_1151285" /HighExp="Salt, S8, S7, BC, Heat, H2O2, Sw, Oxctl, MG-0.2, MG-0.1" /AntisenseName="yisJ" /AntisenseCor="0.24461808844813801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S385" CDS complement(1100743..1101666) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein, CotH paralog" /protein_id="NP_388955.1" /db_xref="EnsemblGenomes-Gn:BSU10740" /db_xref="EnsemblGenomes-Tr:CAB12914" /db_xref="GOA:O06723" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG13097" /db_xref="UniProtKB/Swiss-Prot:O06723" /translation="MERVHLFFHREQLKRKGTAKGLFVTDRSVSPILLTQRDRAEKAS YEISWEKSLLGERTLFLNAEQDDPSLMRRRLAYCFFDQIGVPAPVASYSFLTINGQPE GIYLNIKNHQPAGKRSYGVKTADPRVPLSLFNNDSSAFLHEFFILIRTAGDDELAERI KLYLDVKLFFLWLIGNTCTNQGFYYTFCLNESGRLYVSPMETRSLAVQEWYEEDPLLT KGKTLSSRLLSIPAFRSQYHTLMKNVLKRSFTIERLSPLINEWHLDICQSAADDPFIK KSPFQIEKEQTNILREIEERQDFLQAHLARL*" /label="yisJ CDS" gene complement(1100743..1101666) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /label="yisJ gene" promotor_-10 complement(1101688..1101707) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-10" upshifts complement(1101699) /Source="Nicolas_upshifts" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="upshifts" promotor_-35 complement(1101721..1101730) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-35" promotor_-35 1101750..1101758 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-35" promotor_-10 1101770..1101788 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-10" upshifts 1101775 /Source="Nicolas_upshifts" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="upshifts" CDS 1101821..1102726 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16847875, 27215790, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16847875, 27215790, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydrolase/isomerase involved in remodelling the bacterial envelope" /protein_id="NP_388956.1" /db_xref="EnsemblGenomes-Gn:BSU10750" /db_xref="EnsemblGenomes-Tr:CAB12915" /db_xref="GOA:O06724" /db_xref="InterPro:IPR011234" /db_xref="InterPro:IPR036663" /db_xref="SubtiList:BG13098" /db_xref="UniProtKB/Swiss-Prot:O06724" /translation="MKFATGELYNRMFVGLIIDDEKIMDLQKAEKKLFELETIPGSLI ECIAEGDKFVAHARQLAEWAKKPNDELGSFMYSLSEVKLHAPIPKPSKNIICIGKNYR DHAIEMGSEADIPEHPMVFTKSPVTVTGHGDIVKSHEEVTSQLDYEGELAVVIGKSGT RISKEDAYDHVFGYTIVNDITARDLQKRHKQFFIGKSLDTTCPMGPVLVHKSSIQEPE RLKVETRVNGELRQSGSASDMIFSIPELIETLSKGMTLEAGDIIATGTPSGVGKGFTP PKFLRSGDKIDITIDPIGTLSNQIG*" /label="mblK CDS" gene 1101821..1102726 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /label="mblK gene" S_feature 1102727..1102807 /Source="Nicolas_S_feature" /locus_tag="new_1153150_1153230" /HighExp="S2, Lbstat, S1, Etha, SMMPr, M0t90, M40t90, LoTm, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S386" promotor_-35 1102777..1102780 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1102797..1102816 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1102809 /Source="Nicolas_upshifts" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="upshifts" CDS 1102842..1103198 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27215790; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388957.1" /db_xref="EnsemblGenomes-Gn:BSU10760" /db_xref="EnsemblGenomes-Tr:CAB12916" /db_xref="GOA:O06725" /db_xref="InterPro:IPR010899" /db_xref="SubtiList:BG13099" /db_xref="UniProtKB/Swiss-Prot:O06725" /translation="MTHLHITTWVVALILLFVSYSLYSSGSAKGAKITHMILRLFYIL IILTGAELFVRFANWNGEYAGKMILGIITIGLMEMLLIRKKKEKSTGGLWVGFVIVLL LTVLLGLHLPIGFQLF*" /label="yisL CDS" gene 1102842..1103198 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /label="yisL gene" downshifts 1103095 /Source="Nicolas_upshifts" /id="D583" /incds=1 /nref=1 /ntot=44 /MaxReadThrough="4.28837" /MaxDrop="2.46999" /score="41.4247437" /energy="-11.7" /TU="U866,U867" /idTUdmin="U867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 1103186 /Source="Nicolas_upshifts" /id="D584" /incds=0 /nref=17 /ntot=162 /MaxReadThrough="3.06092" /MaxDrop="3.41506" /score="41.4247437" /energy="-11.7" /TU="U866" /idTUdmin="U867" /TUdmin=3 /isTUend="TRUE" /label="downshifts" upshifts 1103319 /Source="Nicolas_upshifts" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1103322..1103341 /Source="Nicolas_upshift_promotors" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1103366..1106050 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated protease" /protein_id="NP_388958.1" /db_xref="EnsemblGenomes-Gn:BSU10770" /db_xref="EnsemblGenomes-Tr:CAB12917" /db_xref="GOA:P54423" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034084" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG11846" /db_xref="UniProtKB/Swiss-Prot:P54423" /translation="MKRRKFSSVVAAVLIFALIFSLFSPGTKAAAAGAIDQAAALENG KEQTGAMKEPEQVKWYKVTPGATDIQKNSHMALTVKSDSVLNVSVYPSKEKALKDETF EMYRSFTAEDGKSEVIFPYAWSGPYYVKVEYLGEEEPEDGGTAEAAAEAKYTIGYKGT KKQPSDLEEEEACPVEMSVDQKKSGKGILDKLRSIRDEQLSQTAEGKELTSLYYKAAP FIVAKLALNKTARNEIYQDLVTLKPLFDDVSENGASSSYKVTEKDQKAINRLYDKALQ SVPSFLKEEIKKQADRLNMKQLQGKTAGAILTENNIAAKSEVQTTKVIFKVKDNKSLS SVHNEMKGFSASAQSKKDISNVKKAKKLFDNLYSFELPKDEKQNGAYTASAKRVKSAA ATLSKMSNVEFAEPVQEYKSLANDIQYPYQWPLKNNGENGGVKNADVKYEPANTLLSK RKLNDTLIAVVDTGVDSTLADLKGKVRTDLGHNFVGRNNNAMDDQGHGTHVAGIIAAQ SDNGYSMTGLNAKAKIIPVKVLDSAGSGDTEQIALGIKYAADKGAKVINLSLGGGYSR VLEFALKYAADKNVLIAAASGNDGENALSYPASSKYVMSVGATNRMDMTADFSNYGKG LDISAPGSDIPSLVPNGNVTYMSGTSMATPYAAAAAGLLFAQNPKLKRTEVEDMLKKT ADDISFESVDGGEEELYDDYGDPIEIPKTPGVDWHSGYGRLNVMKAVSAADLQLKVNK LESTQTAVRGSAKEGTLIEVMNGKKKLGSAKAGKDNAFKVNIATQKQDQVLYLKATKG DAKTSYKVVVVKGKPSGTPKVNAVKTKDTAVKGKANSKAMIRVKNKSKKVIASAKADA KGTFSVKIKKQKAGTVLYVTAVDTDKKESKEAKVVVEK*" /label="wprA CDS" gene 1103366..1106050 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /label="wprA gene" downshifts complement(1103534) /Source="Nicolas_upshifts" /id="D585" /incds=1 /nref=2 /ntot=155 /MaxReadThrough="0.14981" /MaxDrop="3.98572" /score="9.01750245" /energy="-8" /TU="NA" /idTUdmin="U869" /TUdmin=2563 /isTUend="FALSE" /label="downshifts" downshifts 1106042 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1106081..1106668) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" /label="yisN CDS" gene complement(1106081..1106668) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /label="yisN gene" promotor_-10 complement(1106683..1106702) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1106702) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1106718..1106720) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1106723..1106729 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1106741 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1106744..1106762 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1106747..1106813 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1106814..1108658 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" /label="asnO CDS" gene 1106814..1108658 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /label="asnO gene" S_feature 1108659..1108726 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1108683 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1108788..1109267) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " /label="yizA CDS" gene complement(1108788..1109267) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /label="yizA gene" upshifts complement(1109287) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1109291..1109309) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1109320..1109328) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1109459..1109463 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1109476 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1109478..1109497 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1109499..1110323 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" /label="farP CDS" gene 1109499..1110323 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /label="farP gene" promotor_-35 1109711..1109717 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1109732..1109750 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1109739 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1110333..1111783 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1110353..1111720) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" /label="yisQ CDS" gene complement(1110353..1111720) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /label="yisQ gene" promotor_-35 1111752..1111759 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1111773..1111792 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1111785 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="upshifts" CDS 1111844..1112707 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" /label="yisR CDS" gene 1111844..1112707 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /label="yisR gene" CDS 1112725..1113738 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" /label="iolQ CDS" gene 1112725..1113738 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /label="iolQ gene" downshifts 1113721 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-35 1113790..1113797 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1113812..1113831 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1113831..1113946 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1113831 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="upshifts" CDS 1113947..1114975 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" /label="iolX CDS" gene 1113947..1114975 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /label="iolX gene" downshifts 1114997 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1115026..1115535) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" /label="yisT CDS" gene complement(1115026..1115535) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /label="yisT gene" downshifts complement(1115045) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1115548..1115566) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1115564) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1115578..1115586) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1115585..1116247) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" /label="yisU CDS" gene complement(1115585..1116247) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /label="yisU gene" promotor_-35 1116266..1116272 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1116286..1116305 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1116295 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="upshifts" CDS 1116314..1117768 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" /label="yisV CDS" gene 1116314..1117768 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /label="yisV gene" S_feature complement(1117623..1117775) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1117658) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1117776..1118414) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" /label="yisX CDS" gene complement(1117776..1118414) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /label="yisX gene" S_feature complement(1118415..1118549) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1118463..1118468 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1118484..1118502 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1118485 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="upshifts" S_feature 1118495..1118619 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1118535..1118554) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1118549) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1118569..1118576) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1118620..1119426 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" /label="yisY CDS" gene 1118620..1119426 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /label="yisY gene" downshifts 1119419 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1119454..1120053) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" /label="yisZ CDS" gene complement(1119454..1120053) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /label="yisZ gene" downshifts complement(1119473) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1120050..1121219) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" /label="yitA CDS" gene complement(1120050..1121219) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /label="yitA gene" S_feature complement(1121220..1121331) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1121332..1122042) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" /label="yitB CDS" gene complement(1121332..1122042) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /label="yitB gene" promotor_-10 complement(1122086..1122105) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1122108) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1122118..1122127) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1122157..1122166 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1122180..1122199 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1122191 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="upshifts" CDS 1122227..1122913 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" /label="slpH CDS" gene 1122227..1122913 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /label="slpH gene" CDS 1122910..1123668 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" /label="slpS CDS" gene 1122910..1123668 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /label="slpS gene" downshifts 1123665 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1123713..1124342) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" /label="yitE CDS" gene complement(1123713..1124342) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /label="yitE gene" promotor_-10 complement(1124376..1124394) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1124393) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1124409..1124414) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1124438..1125553) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" /label="yitF CDS" gene complement(1124438..1125553) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /label="yitF gene" downshifts complement(1124467) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1125562..1126830) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" /label="yitG CDS" gene complement(1125562..1126830) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /label="yitG gene" promotor_-10 complement(1126856..1126867) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1126865) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1126881..1126887) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1126942..1127790) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" /label="yitH CDS" gene complement(1126942..1127790) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /label="yitH gene" downshifts complement(1126953) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1127795..1128244) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" /label="yitI CDS" gene complement(1127795..1128244) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /label="yitI gene" promotor_-10 complement(1128265..1128284) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1128279) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1128300..1128301) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1128334..1130172) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" /label="samT CDS" gene complement(1128334..1130172) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /label="samT gene" downshifts complement(1128361) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts complement(1130254) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1130262..1130379) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswK RNA" gene complement(1130262..1130379) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /label="mswK gene" promotor_-10 complement(1130431..1130450) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1130445) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1130465..1130472) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1130486..1130977) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" /label="yitK CDS" gene complement(1130486..1130977) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /label="yitK gene" promotor_-35 1130995..1130998 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1131001..1131020) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1131013..1131032 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1131014 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1131019) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1131035..1131042) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1131076..1131972 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" /label="yitL CDS" gene 1131076..1131972 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /label="yitL gene" downshifts 1131959 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1132025..1132609) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388985.1" /db_xref="EnsemblGenomes-Gn:BSU11040" /db_xref="EnsemblGenomes-Tr:CAB12944" /db_xref="GOA:O06748" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG13118" /db_xref="UniProtKB/Swiss-Prot:O06748" /translation="MKKAFLVFLSVVLVTTVFLVKQQESVAQAKQLEYSGEEIFKGFV FAQGEVGKQLPEVFNKAMTDKLNTKQAKAFANQVVADIKKEDADFFDNLKKAVYSKDA LKVDELLKKAGQIVEEKVEAAKEIAASKDDTSRVQAELVNTVDTANYFYYVSYVAAAG ALILIILAIDITPIAISDNVDREMAIRTLVDELN*" /label="yitM CDS" gene complement(1132025..1132609) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /label="yitM gene" downshifts complement(1132035) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1132606..1133535) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11557812, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with HTTM domain" /protein_id="NP_388987.2" /db_xref="EnsemblGenomes-Gn:BSU11055" /db_xref="EnsemblGenomes-Tr:CAB12946" /db_xref="GOA:O06750" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG13120" /db_xref="UniProtKB/Swiss-Prot:O06750" /translation="MLENIKQTITRWDERNPWTNVYGLARSIIALSSLLTLLINHPSL IMKPASGISSYPACKMNLSLFCLGENNYMMLNLFRWVCIAILVLVVIGWRPRITGVLH WYVSYSLQSSLIVIDGGEQAAAVMTFLLLPITLTDPRKWHWSTRPIEGKRTLGKITAF ISYFVIRIQVAVLYFHSTVAKLSQQEWVDGTAVYYFAQEKTIGFNGFFQALTKPIVTS PFVVIPTWGTLLVQIVIFAALFAPKKHWRLILIIAVFMHEIFAVMLGLISFSIIMAGI LILYLTPIDSTIQFTYIRRLLWNKKHKKGEVSV*" /label="yitO CDS" gene complement(1132606..1133535) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /label="yitO gene" upshifts complement(1132693) /Source="Nicolas_upshifts" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1133520..1134056) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 6289325, 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388988.1" /db_xref="EnsemblGenomes-Gn:BSU11070" /db_xref="EnsemblGenomes-Tr:CAB12947" /db_xref="GOA:O06751" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG13121" /db_xref="UniProtKB/Swiss-Prot:O06751" /translation="MQKSISFFVIFSILWGSLFLFSIIGSLGTTPIPLTKDSKFLMSS ILPQGWGFFSKNPRDTAIGLYEAENASAKVRWPNMRADNLFGLYRYGRSQGVEMGVIY SQVGKEQWTACKEKDLGACKSKAKTVQLKTPAPRPLLCGSYYLTKEDIVPWSYSKYTP SSYQVKSIVKVVISCSKT*" /label="yitP CDS" gene complement(1133520..1134056) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /label="yitP gene" promotor_-10 complement(1134092..1134111) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1134106) /Source="Nicolas_upshifts" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1134126..1134129) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1134197..1134204 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1134219..1134238 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1134222 /Source="Nicolas_upshifts" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="upshifts" CDS 1134234..1134581 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097701.1" /db_xref="EnsemblGenomes-Gn:BSU11079" /db_xref="EnsemblGenomes-Tr:CAX52589" /db_xref="GOA:C0H3Y4" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Y4" /translation="MKTNQVNDRWIVQFRKGIFELAILSLLRSKPMYGYELTSSLKTT SALAISEGAIYPILKRMTEKGWIEFFWEDSLDGPKRKYYKMTQKGEEMLKERLEKYLE THQALLSLSGDLL*" /label="yizB CDS" gene 1134234..1134581 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /label="yizB gene" CDS 1134578..1135165 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23504016" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388989.2" /db_xref="EnsemblGenomes-Gn:BSU11080" /db_xref="EnsemblGenomes-Tr:CAB12948" /db_xref="GOA:O06752" /db_xref="SubtiList:BG13122" /db_xref="UniProtKB/Swiss-Prot:O06752" /translation="MNGQLIIDRYMEELNAELANMPDVERENAIDELKGHITAFVQDR IKAGLSEEELQEAVESEFSHPKELAELMMGDGGETKRRRSLLGKSWISVLLIVTIIAL PLLPSDFRHLPLAVYLMVLAGYVWKRKKLVMFAGVRKNKMRSQKEIVKISRVGAVYLL FLAVVLLLSPFLNALVVLLLIAVSCAAFFLFLNIK*" /label="yitQ CDS" gene 1134578..1135165 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /label="yitQ gene" CDS 1135185..1135478 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388990.1" /db_xref="EnsemblGenomes-Gn:BSU11090" /db_xref="EnsemblGenomes-Tr:CAB12949" /db_xref="GOA:O06753" /db_xref="InterPro:IPR017259" /db_xref="SubtiList:BG13123" /db_xref="UniProtKB/Swiss-Prot:O06753" /translation="MEISINYLLIVIALLFFVVAYFVGIKKQTWMLAGFNEARIRDKD RLARIAGYFFLNSGLFILLNSFISFQGQEQLIPPLILAYGAGVIIYVNKKLVE*" /label="yitR CDS" gene 1135185..1135478 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /label="yitR gene" downshifts 1135458 /Source="Nicolas_upshifts" /id="D601" /incds=0 /nref=119 /ntot=240 /MaxReadThrough="1.96008" /MaxDrop="5.72545" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1135502 /Source="Nicolas_upshifts" /id="D602" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="0.34732" /MaxDrop="3.0285" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS 1135614..1137230 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1917867, 16672610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1917867, 16672610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral protease B" /protein_id="NP_388991.1" /db_xref="EnsemblGenomes-Gn:BSU11100" /db_xref="EnsemblGenomes-Tr:CAB12950" /db_xref="GOA:P39899" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10691" /db_xref="UniProtKB/Swiss-Prot:P39899" /translation="MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYI IEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNANSHFRVSKTIKDPKTKQTFFKLT EVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEA SIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESF NAIHEAAGTGIGVSGDEKSFDVTEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQ LIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSFDQNGARITSTVHVG KQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALN ESISDIMGAMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYG GVHINSSIHNKAAYLLAEGGVHHGVQVEGIGREASEQIYYRALTYYVTASTDFSMMKQ AAIEAANDLYGEGSKQSASVEKAYEAVGIL*" /label="nprB CDS" gene 1135614..1137230 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /label="nprB gene" downshifts 1137218 /Source="Nicolas_upshifts" /id="D603" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="0.278770000000001" /MaxDrop="3.08544" /score="2.81939887" /energy="-8.6" /TU="NA" /idTUdmin="U890" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" CDS complement(1137277..1138128) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit B" /protein_id="NP_388992.1" /db_xref="EnsemblGenomes-Gn:BSU11110" /db_xref="EnsemblGenomes-Tr:CAB12951" /db_xref="GOA:P70945" /db_xref="InterPro:IPR003797" /db_xref="SubtiList:BG12244" /db_xref="UniProtKB/Swiss-Prot:P70945" /translation="MTVHLIADSATDLPRSYFEEKGIGFIPLRVSLGDKEFEDAVTIH ADQIFEAMQNGETPKTSQASPQTIKNVFLQYAETGDPALYIAFSSGLSGTYQTAVMIA NEVKEEFPDFDLRVIDSKCASLGYGLAVRHAADLCINGNTIQEIETSVKNFCSQLEHI FTVDDLTYLARGGRISKTSAFVGGLLNIKPLLQMEDGKLVPLEKIRGQKKLFKRIIEL MKERGDDWSNQTVGISYAANKEKATDMKHLIEEAFKPKEIIMHPISSAIGSHAGPGTL AIFFLRK*" /label="fakBB CDS" gene complement(1137277..1138128) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /label="fakBB gene" downshifts complement(1137294) /Source="Nicolas_upshifts" /id="D604" /incds=0 /nref=209 /ntot=263 /MaxReadThrough="0.727580000000001" /MaxDrop="6.86927" /score="-1.24586831" /energy="-7.7" /TU="NA" /idTUdmin="U892" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1137675..1137682 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1137697..1137716 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1137702..1138227 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" upshifts 1137704 /Source="Nicolas_upshifts" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1138169..1138188) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1138192) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1138206..1138211 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1138226..1138244 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1138229 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" CDS 1138266..1139108 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" /label="yitT CDS" gene 1138266..1139108 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /label="yitT gene" promotor_-35 1138761..1138769 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1138780..1138798 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1138780 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="upshifts" S_feature 1139109..1139222 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1139223..1139582 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" /label="ipi CDS" gene 1139223..1139582 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /label="ipi gene" downshifts 1139571 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1139613..1139810) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" /label="yizC CDS" gene complement(1139613..1139810) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /label="yizC gene" downshifts complement(1139626) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1139811..1140007) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1140007) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1140009..1140020) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1140035..1140041) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1140067..1140879) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" /label="ribZC CDS" gene complement(1140067..1140879) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /label="ribZC gene" promotor_-10 complement(1140917..1140936) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1140937..1140944 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1140937) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1140950..1140957) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1140956..1140975 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1140958 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1141000..1141767 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" /label="yitV CDS" gene 1141000..1141767 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /label="yitV gene" promotor_-35 1141776..1141782 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1141796 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1141797..1141816 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1141831..1142139 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" /label="yitW CDS" gene 1141831..1142139 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /label="yitW gene" downshifts 1142124 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" /label="downshifts" S_feature 1142169..1142434 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1142435..1143865 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" /label="yitY CDS" gene 1142435..1143865 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /label="yitY gene" CDS 1143910..1144404 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" /label="yitZ CDS" gene 1143910..1144404 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /label="yitZ gene" downshifts 1144368 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1144542..1144549 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1144548 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1144563..1144582 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1144611..1145648 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" /label="argC CDS" gene 1144611..1145648 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /label="argC gene" CDS 1145668..1146888 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" /label="argJ CDS" gene 1145668..1146888 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /label="argJ gene" CDS 1146903..1147679 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" /label="argB CDS" gene 1146903..1147679 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /label="argB gene" CDS 1147676..1148833 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" /label="argD CDS" gene 1147676..1148833 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /label="argD gene" CDS 1148904..1149959 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /modified_by="User" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGLSNGPGDPKAIQPY LGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMTSQ NHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEWIF DDYLKNVIPARREIAHA*" /label="Delta6_BSU_11230_SNPvariant" gene 1148904..1149959 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /modified_by="User" /label="Delta6_BSU_11230_SNPvariant" Polymorphism join(1149514,1149515) /Source="geneious" /ID="SNP_BsDelta6_1199938_1199943" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=6 /Amino_Acid_Change="GIV -> G" /CDS_Position=612 /Change="-AATTGT" /Codon_Change="GGA,ATT,GTG -> GGG" /Coverage="183 -> 185" /locus_tag="BSU_11230" /Protein_Effect="Deletion" /Reference_Frequency /Reference_Nucleotides="AATTGT" /Variant_Nucleotides /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="Delta6_BSU_11230_SNPvariant" / /modified_by="User" /label="Polymorphism_Delta6" misc_feature complement(1149793..1149812) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1149803) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1149952..1153044 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" /label="carB CDS" gene 1149952..1153044 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /label="carB gene" CDS 1153032..1153991 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" /label="argF CDS" gene 1153032..1153991 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /label="argF gene" downshifts 1153954 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" /label="downshifts" S_feature complement(1153994..1154268) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1154019..1154025 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1154027) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 1154040..1154051 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1154061 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="upshifts" CDS 1154077..1154256 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" /label="yjzC CDS" gene 1154077..1154256 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /label="yjzC gene" downshifts 1154266 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1154302..1154487) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" /label="yjzD CDS" gene complement(1154302..1154487) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /label="yjzD gene" downshifts complement(1154313) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1154516..1154535) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1154533) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1154546..1154553) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1154588..1154594 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1154606..1154625 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1154611 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1154668..1154677 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1154677 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1154690..1154709 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1154736..1155470 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" /label="yjaU CDS" gene 1154736..1155470 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /label="yjaU gene" S_feature complement(1155229..1155831) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1155451..1155456 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1155469 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" /label="downshifts" upshifts 1155469 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1155472..1155490 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1155552..1156109 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" /label="yjaV CDS" gene 1155552..1156109 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /label="yjaV gene" promotor_-10 complement(1155811..1155830) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1155831) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1155845..1155849) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1156116..1156123 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1156138..1156157 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1156150 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1156200..1157153 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" /label="med CDS" gene 1156200..1157153 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /label="med gene" promotor_-35 1156817..1156821 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1156837..1156856 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1156850 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1157168..1157359 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" /label="comZ CDS" gene 1157168..1157359 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /label="comZ gene" downshifts 1157338 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1157383..1157723 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1157389..1157628) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" /label="yjzB CDS" gene complement(1157389..1157628) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /label="yjzB gene" downshifts complement(1157405) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1157641..1157660) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1157662) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1157674..1157683) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1157689..1157696 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1157711..1157730 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1157725 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="upshifts" CDS 1157793..1158731 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" /label="fabHA CDS" gene 1157793..1158731 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /label="fabHA gene" promotor_-35 1157870..1157879 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1157888 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1157891..1157906 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1158754..1159995 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" /label="fabF CDS" gene 1158754..1159995 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /label="fabF gene" promotor_-10 complement(1158968..1158986) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1158976) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1159002..1159007) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1159846 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 1159979 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 1160020..1160029 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1160042..1160061 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1160044 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="upshifts" promotor_-35 1160056..1160064 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1160071..1160856 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" /label="yjaZ CDS" gene 1160071..1160856 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /label="yjaZ gene" promotor_-10 1160076..1160094 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1160088 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1160857..1160941 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1160873..1160891) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1160890) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1160906..1160911) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1160909..1160916 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1160931..1160950 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1160943..1161047 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1160943 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1161048..1162034 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" /label="appD CDS" gene 1161048..1162034 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /label="appD gene" CDS 1162031..1163020 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" /label="appF CDS" gene 1162031..1163020 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /label="appF gene" misc_feature 1163026..1163032 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1163031..1163107 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1163031 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1163108..1163599 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" /label="appAn CDS" gene 1163108..1163599 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo /label="appAn gene" CDS 1163572..1164738 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" /label="appAc CDS" gene 1163572..1164738 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo /label="appAc gene" downshifts 1164729 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" /label="downshifts" CDS 1164814..1165764 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" /label="appB CDS" gene 1164814..1165764 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /label="appB gene" CDS 1165781..1166692 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" /label="appC CDS" gene 1165781..1166692 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /label="appC gene" downshifts 1166706 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" S_feature 1166751..1166858 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1166831..1166836 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1166852..1166870 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1166860 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1166897..1167649 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" /label="yjbA CDS" gene 1166897..1167649 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /label="yjbA gene" downshifts 1167629 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1167684..1168676) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" /label="trpS CDS" gene complement(1167684..1168676) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /label="trpS gene" downshifts complement(1167705) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" misc_RNA complement(1168735..1168949) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboWA RNA" gene complement(1168735..1168949) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /label="tboWA gene" downshifts complement(1168783) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" misc_feature complement(1168968..1168987) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1168981) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1169236..1169243 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1169257..1169419 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1169258..1169277 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1169258 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1169420..1171057 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" /label="oppA CDS" gene 1169420..1171057 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /label="oppA gene" downshifts 1170951 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 1171058..1171164 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1171165..1172100 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" /label="oppB CDS" gene 1171165..1172100 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /label="oppB gene" promotor_-10 complement(1171208..1171227) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1171225) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1171243..1171249) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1172104..1173021 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" /label="oppC CDS" gene 1172104..1173021 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /label="oppC gene" CDS 1173026..1174102 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" /label="oppD CDS" gene 1173026..1174102 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /label="oppD gene" CDS 1174104..1175021 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" /label="oppF CDS" gene 1174104..1175021 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /label="oppF gene" downshifts 1174991 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 1175071..1175074 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1175087 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1175089..1175108 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1175128..1176345 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" /label="yjbB CDS" gene 1175128..1176345 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /label="yjbB gene" promotor_-35 1176398..1176407 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1176420..1176435 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1176429..1176508 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1176429 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="upshifts" CDS 1176509..1177087 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" /label="yjbC CDS" gene 1176509..1177087 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /label="yjbC gene" S_feature 1177088..1177202 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1177139..1177158) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1177143) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1177172..1177179) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1177205..1177218 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1177205 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="upshifts" CDS 1177268..1177663 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" /label="spxA CDS" gene 1177268..1177663 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /label="spxA gene" promotor_no_box complement(1177499..1177599) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1177539) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1177661 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1177706..1178495 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1177706..1178362) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" /label="yjbE CDS" gene complement(1177706..1178362) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /label="yjbE gene" promotor_-10 complement(1178392..1178410) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1178407) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1178425..1178430) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1178468..1178475 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1178489..1178508 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1178497..1178638 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1178497 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="upshifts" CDS 1178532..1178672 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" /label="conserved hypothetical protein CDS" gene 1178532..1178672 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /label="gene" CDS 1178639..1179295 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" /label="mecA CDS" gene 1178639..1179295 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /label="mecA gene" downshifts 1179285 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" /label="downshifts" CDS complement(1179290..1179412) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" /label="conserved hypothetical protein CDS" gene complement(1179290..1179412) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /label="gene" S_feature 1179330..1179419 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1179398..1179406 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1179417..1179435 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1179421..1179485 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1179421 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1179486..1180607 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" /label="coiA CDS" gene 1179486..1180607 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /label="coiA gene" promotor_-35 1180261..1180267 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1180279 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-10 1180282..1180300 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1180493..1180501 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1180513..1180531 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1180520 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-35 1180601..1180607 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1180622..1180633 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1180631 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1180654..1182666 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" /label="pepF CDS" gene 1180654..1182666 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /label="pepF gene" promotor_-35 1180729..1180736 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1180751..1180770 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1180763 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="upshifts" downshifts 1182613 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 1182667..1182968 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1182704..1182871) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" /label="yizD CDS" gene complement(1182704..1182871) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /label="yizD gene" downshifts complement(1182717) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1182891..1182909) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1182907) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1182925..1182930) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1182961..1182968 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1182970..1183095 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1182970 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1182976..1183114 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" /label="roxS RNA" gene 1182976..1183114 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /label="roxS gene" promotor_-10 1182983..1183002 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1183052 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" /label="downshifts" CDS complement(1183185..1184084) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" /label="spxH CDS" gene complement(1183185..1184084) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /label="spxH gene" downshifts complement(1183216) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1183420..1183425 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1183432 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1183441..1183459 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1183448..1185349 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1184081..1184479) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" /label="yjbI CDS" gene complement(1184081..1184479) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /label="yjbI gene" S_feature complement(1184480..1184659) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1184651..1184670) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1184659) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1184682..1184689) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1184734..1185279) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" /label="cwlQ CDS" gene complement(1184734..1185279) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /label="cwlQ gene" downshifts complement(1184758) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" S_feature complement(1185280..1185482) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1185483..1186055) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" /label="yjbK CDS" gene complement(1185483..1186055) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /label="yjbK gene" promotor_-10 complement(1185628..1185646) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1185637) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 complement(1185659..1185666) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1186084..1186103) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1186101) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 1186117..1186120 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1186118..1186125) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1186133 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1186136..1186155 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1186180..1186548 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" /label="yjbL CDS" gene 1186180..1186548 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /label="yjbL gene" CDS 1186577..1187212 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" /label="relP CDS" gene 1186577..1187212 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /label="relP gene" CDS 1187231..1188031 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" /label="ppnKA CDS" gene 1187231..1188031 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /label="ppnKA gene" CDS 1188094..1188945 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" /label="yjbO CDS" gene 1188094..1188945 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /label="yjbO gene" downshifts 1188904 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1188958..1189692) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" /label="prpE CDS" gene complement(1188958..1189692) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /label="prpE gene" downshifts complement(1188980) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" promotor_-35 1189814..1189818 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1189835..1189854 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1189849 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="upshifts" S_feature 1189850..1189926 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1189927..1191771 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" /label="kefQ CDS" gene 1189927..1191771 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /label="kefQ gene" misc_feature complement(1190254..1190273) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1190278) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1191773..1191780 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1191794..1191813 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1191800 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="upshifts" misc_RNA 1191833..1191941 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswA RNA" gene 1191833..1191941 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /label="tswA gene" downshifts 1191936 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS 1192020..1192730 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" /label="tenA CDS" gene 1192020..1192730 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /label="tenA gene" CDS 1192705..1193322 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" /label="tenI CDS" gene 1192705..1193322 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /label="tenI gene" CDS 1193306..1194415 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" /label="thiO CDS" gene 1193306..1194415 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /label="thiO gene" CDS 1194415..1194615 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" /label="thiS CDS" gene 1194415..1194615 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /label="thiS gene" CDS 1194612..1195382 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" /label="thiG CDS" gene 1194612..1195382 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /label="thiG gene" CDS 1195379..1196389 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" /label="thiF CDS" gene 1195379..1196389 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /label="thiF gene" CDS 1196408..1197223 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" /label="thiD CDS" gene 1196408..1197223 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /label="thiD gene" downshifts 1197197 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1197270..1197276 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1197289..1197308 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1197299 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="upshifts" CDS 1197359..1198135 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" /label="fabI CDS" gene 1197359..1198135 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /label="fabI gene" downshifts 1198124 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" /label="downshifts" promotor_-35 1198183..1198188 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1198204..1198222 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1198208 /Source="Nicolas_upshifts" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1198220..1198234) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1198220) /Source="Nicolas_upshifts" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1198236..1198919 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outer coat protein" /protein_id="NP_389055.1" /db_xref="EnsemblGenomes-Gn:BSU11730" /db_xref="EnsemblGenomes-Tr:CAB13030" /db_xref="GOA:O31622" /db_xref="InterPro:IPR025439" /db_xref="SubtiList:BG13153" /db_xref="UniProtKB/Swiss-Prot:O31622" /translation="MKMSNKKRNADKKPLMYIVQPDYAETTRSSMQEIVIKRKADKPA PPKAEEKPAYHEKQQEEAVAQDVLQEDQKPAAEPVSQQTQEAREPENIKSQEEQKAEP QAVEETVEHEPPKAEKKEEPALEARKPEKEPEAVHSADKAEEKAPPARKVKKPMSKMT IHEKIDFLTKLPHNMPRALCLIEANGRTYRGVIVGRRNDSVLLRTTGNGAPTELAIDD ITSLHPLGF*" /label="cotO CDS" gene 1198236..1198919 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /label="cotO gene" promotor_-35 complement(1198242..1198246) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1198914 /Source="Nicolas_upshifts" /id="D637" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="3.37645" /MaxDrop="4.6587" /score="18.0229289" /energy="-13.4" /TU="U945" /idTUdmin="U945" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 1199002 /Source="Nicolas_upshifts" /id="D638" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.44926" /MaxDrop="4.55934" /score="18.0229289" /energy="-13.4" /TU="NA" /idTUdmin="U945" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1199013..1199459) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 19933362, 26341943, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 19933362, 26341943, 27320701; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction, crust layer)" /protein_id="NP_389056.1" /db_xref="EnsemblGenomes-Gn:BSU11740" /db_xref="EnsemblGenomes-Tr:CAB13031" /db_xref="GOA:Q08312" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10499" /db_xref="UniProtKB/Swiss-Prot:Q08312" /translation="MSQKTSSCVREAVENIEDLQNAVEEDCPTGCHSKLLSVSHSLGD TVPFAIFTSKSTPLVAFGNVGELDNGPCFNTVFFRVERVHGSCATLSLLIAFDEHKHI LDFTDKDTVCEVFRLEKTNYCIEVDLDCFCAINCLNPRLINRTHHH*" /label="cotZ CDS" gene complement(1199013..1199459) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /label="cotZ gene" downshifts complement(1199034) /Source="Nicolas_upshifts" /id="D639" /incds=0 /nref=7 /ntot=50 /MaxReadThrough="8.44444" /MaxDrop="7.17581" /score="2.03943557" /energy="-9.3" /TU="U949" /idTUdmin="U950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1199460..1199586) /Source="Nicolas_S_feature" /locus_tag="new_1249889_1250015_c" /HighExp="S8, S7, S6, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigEF" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S420" CDS complement(1199587..1200075) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 14766913, 26341943, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 14766913, 26341943, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="outer spore coat protein (crust layer, insolublefraction)" /protein_id="NP_389057.1" /db_xref="EnsemblGenomes-Gn:BSU11750" /db_xref="EnsemblGenomes-Tr:CAB13032" /db_xref="GOA:Q08311" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10498" /db_xref="UniProtKB/Swiss-Prot:Q08311" /translation="MSCGKTHGRHENCVCDAVEKILAEQEAVEEQCPTGCYTNLLNPT IAGKDTIPFLVFDKKGGLFSTFGNVGGFVDDMQCFESIFFRVEKLCDCCATLSILRPV DVKGDTLSVCHPCDPDFFGLEKTDFCIEVDLGCFCAIQCLSPELVDRTSPHKDKKHHH NG*" /label="cotY CDS" gene complement(1199587..1200075) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /label="cotY gene" promotor_-35 1199755..1199761 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1199776..1199795 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1199794 /Source="Nicolas_upshifts" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1200071..1200075 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1200084..1200098 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1200102 /Source="Nicolas_upshifts" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1200112..1200131) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1200129) /Source="Nicolas_upshifts" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1200145..1200154) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1200161..1200179) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1200178) /Source="Nicolas_upshifts" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1200195..1200200) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1200212 /Source="Nicolas_upshifts" /id="D640" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.28604" /MaxDrop="4.18677" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1200227..1200745) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389058.1" /db_xref="EnsemblGenomes-Gn:BSU11760" /db_xref="EnsemblGenomes-Tr:CAB13033" /db_xref="GOA:Q08313" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10500" /db_xref="UniProtKB/Swiss-Prot:Q08313" /translation="MESRPYSWVALDPDCDHPLDDKEKDKEKHERKCHCDVCCNGNGF FGNDNAFIDQDLAQANLNKQVSDETIIIRDSCDINVTSTDVQAVTSVVTALNAAVVTA TLTSIADGVIAELVAQDLLQLTANKQVNRQKLLIECSRGVNVTTVDADIATLISTATN TLVAILVITLVL*" /label="cotX CDS" gene complement(1200227..1200745) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /label="cotX gene" downshifts complement(1200251) /Source="Nicolas_upshifts" /id="D641" /incds=0 /nref=76 /ntot=102 /MaxReadThrough="1.79219" /MaxDrop="8.69761" /score="18.5755652" /energy="-10.4" /TU="U952" /idTUdmin="U952" /TUdmin="-29" /isTUend="FALSE" /label="downshifts" downshifts 1200256 /Source="Nicolas_upshifts" /id="D642" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.2156" /MaxDrop="3.69222" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature complement(1200746..1200843) /Source="Nicolas_S_feature" /locus_tag="new_1251175_1251272_c" /HighExp="S8, S7, S6, BT, B36, G/S, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.748" /TUlongSig="SigK" /TUlongPSig="0.98" /label="S421" CDS complement(1200844..1201161) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8509331, 19304857, 21665972, 25872412" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509331, 19304857, 21665972, 25872412; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (outemost layer)" /protein_id="NP_389059.1" /db_xref="EnsemblGenomes-Gn:BSU11770" /db_xref="EnsemblGenomes-Tr:CAB13034" /db_xref="GOA:Q08310" /db_xref="SubtiList:BG10497" /db_xref="UniProtKB/Swiss-Prot:Q08310" /translation="MSDNDKFKEELAKLPEVDPMTKMLVQNIFSKHGVTKDKMKKVSD EEKEMLLNLVKDLQAKSQALIENQKKKKEEAAAQEQKNTKPLSRREQLIEQIRQRRKN DNN*" /label="cotW CDS" gene complement(1200844..1201161) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /label="cotW gene" CDS complement(1201202..1201588) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389060.1" /db_xref="EnsemblGenomes-Gn:BSU11780" /db_xref="EnsemblGenomes-Tr:CAB13035" /db_xref="GOA:Q08309" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10496" /db_xref="UniProtKB/Swiss-Prot:Q08309" /translation="MSFEEKVESLHPAIFEQLSSEFEQQIEVIDCENITIDTSHITAA LSIQAFVTTMIIVATQLVIADEDLADAVASEILILDSSQIKKRTIIKIINSRNIKITL SADEIITFVQILLQVLNSILSELDVL*" /label="cotV CDS" gene complement(1201202..1201588) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /label="cotV gene" promotor_-35 1201584..1201588 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1201596..1201610 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1201598 /Source="Nicolas_upshifts" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1201608..1201627) /Source="Nicolas_upshift_promotors" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1201630) /Source="Nicolas_upshifts" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1201632..1202136) /Source="Nicolas_S_feature" /locus_tag="new_1252061_1252565_c" /HighExp="S8, S6, S7, BT, S5, B36, Pyr, C30, G/S, nit" /AntisenseName="yjcA" /AntisenseCor="0.69838474492609404" /AntisenseRegPval="-39.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S422" promotor_-35 1201685..1201690 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 1201706..1201724 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1201708 /Source="Nicolas_upshifts" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="upshifts" CDS 1201748..1202104 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="NP_389061.1" /db_xref="EnsemblGenomes-Gn:BSU11790" /db_xref="EnsemblGenomes-Tr:CAB13036" /db_xref="GOA:O31623" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13154" /db_xref="UniProtKB/Swiss-Prot:O31623" /translation="MVINGLTIVLLSLAVFRLARLLVFDTIMAPLRSLFHEEKEEKDA DGNIETYIVIKGTGVRAFIGELLSCYWCTGVWCAGFLILCQAVIPQAAQWLILLLAIA GLAGIIETLVSKWLQE*" /label="yjcA CDS" gene 1201748..1202104 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /label="yjcA gene" promotor_-35 1202114..1202123 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 complement(1202121..1202140) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-10" CDS complement(1202129..1202362) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="protein remnant" /db_xref="PSEUDO:SOX90549.1" /translation="MLSETASLKKQKTGVLRFLCQAIEAFSFYFRTRSLSFLSFLIDT MNLYMEIFGKVYDADSFLSPSFPYVIYATLCVF*" /label="protein remnant CDS" gene complement(1202129..1202362) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /pseudo /label="gene" upshifts complement(1202136) /Source="Nicolas_upshifts" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="upshifts" S_feature 1202137..1202323 /Source="Nicolas_S_feature" /locus_tag="new_1252566_1252752" /HighExp="S8, S6, S7, BT, S5, B36, S4, S3, G/S, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.26970100000000002" /TUshortSig="SigK, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S423" promotor_-10 1202137..1202154 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1202137 /Source="Nicolas_upshifts" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="upshifts" promotor_-35 complement(1202154..1202163) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-35" downshifts complement(1202180) /Source="Nicolas_upshifts" /id="D643" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.12564" /MaxDrop="4.58782" /score="-6.14331629" /energy="-6.8" /TU="NA" /idTUdmin="U954" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" downshifts 1202280 /Source="Nicolas_upshifts" /id="D644" /incds=0 /nref=3 /ntot=32 /MaxReadThrough="5.73879" /MaxDrop="3.6919" /score="33.8150878" /energy="-6.8" /TU="U953,U955" /idTUdmin="U953" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" upshifts complement(1202334) /Source="Nicolas_upshifts" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1202335..1202344 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1202342..1202349) /Source="Nicolas_upshift_promotors" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1202358..1202377 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1202368 /Source="Nicolas_upshifts" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="upshifts" CDS 1202386..1202592 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097704.1" /db_xref="EnsemblGenomes-Gn:BSU11799" /db_xref="EnsemblGenomes-Tr:CAX52594" /db_xref="UniProtKB/Swiss-Prot:C0H3Y7" /translation="MNEFEKWIEGRYEPHEQKQKEHEDTMGSIRKDLDAFDKAGLEFE DEIEELAEKTEALLKKHQAQYDQS*" /label="yjzK CDS" gene 1202386..1202592 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /label="yjzK gene" CDS 1202429..1202644 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="YP_009513951.1" /translation="MNKSKKSMKTRWAVSEKTWMHLIKPVWNLKMRLKSWLKKRRPYL KNIKLNMINRKSANALCEYPSRSQQLT*" /label="yjcB CDS" gene 1202429..1202644 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /label="yjcB gene" promotor_-35 1202616..1202625 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1202638..1202657 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1202643 /Source="Nicolas_upshifts" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1202650..1202664) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1202664) /Source="Nicolas_upshifts" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1202674..1202678) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1202674..1202823 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523132, 20156992, 21670523; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097705.1" /db_xref="EnsemblGenomes-Gn:BSU11809" /db_xref="EnsemblGenomes-Tr:CAX52595" /db_xref="GOA:C0H3Y8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y8" /translation="MGFGYGFGGGYGGGCYGGYAGGYGGGYGSTFVLLVVLFILLIIV GASFF*" /label="yjcZ CDS" gene 1202674..1202823 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /label="yjcZ gene" downshifts 1202764 /Source="Nicolas_upshifts" /id="D645" /incds=0 /nref=4 /ntot=29 /MaxReadThrough="8.16203" /MaxDrop="4.48861" /score="1.53429015" /energy="-22.4" /TU="U957,U958" /idTUdmin="U955" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature 1202824..1202955 /Source="Nicolas_S_feature" /locus_tag="new_1253253_1253384" /HighExp="S7, BT, S8, B36, S6, G/S, Pyr, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S424" CDS 1202956..1203210 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 14702409, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 14702409, 20435725; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein needed for heat resistance" /protein_id="NP_389063.2" /db_xref="EnsemblGenomes-Gn:BSU11810" /db_xref="EnsemblGenomes-Tr:CAB13038" /db_xref="GOA:O31625" /db_xref="InterPro:IPR025942" /db_xref="SubtiList:BG13156" /db_xref="UniProtKB/Swiss-Prot:O31625" /translation="MDNQFFKNIEKKTGVKMQDVMNLAGSLQNANFKDENTVRSVINR VAQMANRRVPKELEDKIVESITSGKEKLDFGTISKMMDNK*" /label="spoVIF CDS" gene 1202956..1203210 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /label="spoVIF gene" downshifts 1203195 /Source="Nicolas_upshifts" /id="D646" /incds=0 /nref=40 /ntot=79 /MaxReadThrough="5.66609" /MaxDrop="5.8411" /score="7.68851688" /energy="-10.7" /TU="U957,U958" /idTUdmin="U955" /TUdmin=541 /isTUend="FALSE" /label="downshifts" downshifts complement(1203214) /Source="Nicolas_upshifts" /id="D647" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="3.12148" /MaxDrop="4.34051" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=88 /isTUend="FALSE" /label="downshifts" S_feature 1203240..1204340 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1203284..1205563) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" /label="yjcD CDS" gene complement(1203284..1205563) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /label="yjcD gene" downshifts complement(1203302) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1205438..1205612) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1205491..1205499 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1205510..1205528 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1205514..1205649 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1205514 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1205600..1205619) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1205611) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1205627..1205633 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1205635..1205639) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1205648..1205666 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1205651 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1205680..1205934 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" /label="yjzE CDS" gene 1205680..1205934 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /label="yjzE gene" downshifts 1205910 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1206000) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" /label="downshifts" CDS complement(1206007..1206429) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" /label="yjcF CDS" gene complement(1206007..1206429) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /label="yjcF gene" CDS complement(1206433..1206948) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" /label="yjcG CDS" gene complement(1206433..1206948) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /label="yjcG gene" CDS complement(1206985..1207707) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" /label="yjcH CDS" gene complement(1206985..1207707) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /label="yjcH gene" misc_feature complement(1207746..1207765) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1207767) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1207816..1207823 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1207838..1207857 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1207842 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1207875..1207995 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswA RNA" gene 1207875..1207995 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /label="mswA gene" downshifts 1208000 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" CDS 1208063..1209184 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" /label="metI CDS" gene 1208063..1209184 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /label="metI gene" CDS 1209177..1210349 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" /label="metC CDS" gene 1209177..1210349 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /label="metC gene" downshifts 1210332 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" misc_feature 1210366..1210384 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1210376 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="upshifts" S_feature 1210377..1211906 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1210382..1210927) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" /label="yjcK CDS" gene complement(1210382..1210927) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /label="yjcK gene" downshifts complement(1210403) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1210997..1212187) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" /label="yjcL CDS" gene complement(1210997..1212187) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /label="yjcL gene" promotor_-10 complement(1212213..1212232) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1212217) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1212247..1212254) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1212281..1212288 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1212292 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1212302..1212321 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1212360..1212432 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val2 tRNA" gene 1212360..1212432 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /label="trnSL-Val2 gene" promotor_-10 complement(1212374..1212391) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1212388) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1212412..1212418) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1212422 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" /label="downshifts" S_feature complement(1212447..1213182) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1212467..1214115 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1212476) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1213184..1213272) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1213227) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" /label="downshifts" CDS complement(1213273..1214502) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" /label="yjcM CDS" gene complement(1213273..1214502) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /label="yjcM gene" downshifts complement(1213395) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" /label="downshifts" downshifts 1214072 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1214503..1214588) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1214543..1214550 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1214565..1214584 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1214574..1214593) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1214578 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1214592) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1214606..1214612) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1214628..1214948 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" /label="yjcN CDS" gene 1214628..1214948 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /label="yjcN gene" downshifts 1214958 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" /label="downshifts" S_feature 1215003..1215100 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1215101..1215232 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " /label="yjzF CDS" gene 1215101..1215232 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /label="yjzF gene" CDS 1215248..1215421 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" /label="yjzG CDS" gene 1215248..1215421 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /label="yjzG gene" CDS 1215458..1215919 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" /label="yjcO CDS" gene 1215458..1215919 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /label="yjcO gene" promotor_-35 1215890..1215897 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1215912..1215931 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1215920..1216160 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1215920 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="upshifts" promotor_-35 1216133..1216140 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1216154..1216172 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1216162 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1216185..1216688 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" /label="yjcP CDS" gene 1216185..1216688 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /label="yjcP gene" CDS 1216700..1216984 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" /label="yjcQ CDS" gene 1216700..1216984 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /label="yjcQ gene" downshifts 1216954 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1216986) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1216997..1217000) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1217145..1217672 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" /label="yjcR CDS" gene 1217145..1217672 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /label="yjcR gene" promotor_-35 1217819..1217824 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1217837..1217856 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1217840 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="upshifts" CDS 1217846..1218163 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" /label="yjcS CDS" gene 1217846..1218163 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /label="yjcS gene" S_feature 1218164..1218399 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1218400..1219155 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" /label="yjdA CDS" gene 1218400..1219155 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /label="yjdA gene" S_feature 1219156..1219243 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1219200 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(1219243..1219303) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1219274) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1219304..1219651) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" /label="yjdB CDS" gene complement(1219304..1219651) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /label="yjdB gene" promotor_-10 complement(1219683..1219701) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1219696) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1219698..1220154) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1219712..1219720) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1220114..1220132 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1220126 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="upshifts" promotor_-10 complement(1220132..1220151) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1220154) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1220165..1220172) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1220202..1222148 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" /label="manR CDS" gene 1220202..1222148 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /label="manR gene" downshifts 1222124 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 1222224..1222227 /Source="Nicolas_upshift_promotors" /id="U978" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.936063936063936" /xcortree=1565 /SigmaFactorBS="tttattaccggaacctatggtaaaaaaagcGATTttaatgag ctgatttCGGTATACAGTTGAGACAAGatcttattattcacactttaaaggaggtttc c" /listShort="manP, manA, S439, S440, yjdF, yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1222243..1222262 /Source="Nicolas_upshift_promotors" /id="U978" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.936063936063936" /xcortree=1565 /SigmaFactorBS="tttattaccggaacctatggtaaaaaaagcGATTttaatgag ctgatttCGGTATACAGTTGAGACAAGatcttattattcacactttaaaggaggtttc c" /listShort="manP, manA, S439, S440, yjdF, yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1222254 /Source="Nicolas_upshifts" /id="U978" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.936063936063936" /xcortree=1565 /SigmaFactorBS="tttattaccggaacctatggtaaaaaaagcGATTttaatgag ctgatttCGGTATACAGTTGAGACAAGatcttattattcacactttaaaggaggtttc c" /listShort="manP, manA, S439, S440, yjdF, yjdI" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1222266) /Source="Nicolas_upshifts" /id="U979" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.748251748251748" /psig="0.14985014985015" /xcortree=304 /SigmaFactorBS="tcggacaagatgtaatcgctaacagtttcataggaaaCCTCC TTTAAAGTGTgaataataagatcttgtctcaactgtataccgaaatcagctcattaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1222275..1222289) /Source="Nicolas_upshift_promotors" /id="U979" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.748251748251748" /psig="0.14985014985015" /xcortree=304 /SigmaFactorBS="tcggacaagatgtaatcgctaacagtttcataggaaaCCTCC TTTAAAGTGTgaataataagatcttgtctcaactgtataccgaaatcagctcattaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1222296..1224248 /gene="manP" /locus_tag="BSU_12010" /old_locus_tag="BSU12010" /EC_number="2.7.1.191" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10627040, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627040, 10960106, 23551403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannose-specificenzyme IIBCA component" /protein_id="NP_389083.2" /db_xref="EnsemblGenomes-Gn:BSU12010" /db_xref="EnsemblGenomes-Tr:CAB13058" /db_xref="GOA:O31645" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R48" /db_xref="SubtiList:BG13176" /db_xref="UniProtKB/Swiss-Prot:O31645" /translation="MKLLAITSCPNGIAHTYMAAENLQKAADRLGVSIKVETQGGIGV ENKLTEEEIREADAIIIAADRSVNKDRFIGKKLLSVGVQDGIRKPEELIQKALNGDIP VYRSATKSESGNHQEKKQNPIYRHLMNGVSFMVPFIVVGGLLIAVALTLGGEKTPKGL VIPDDSFWKTIEQIGSASFSFMIPILAGYIAYSIADKPGLVPGMIGGYIAATGSFYDS ASGAGFLGGIIAGFLAGYAALWIKKLKVPKAIQPIMPIIIIPVFASLIVGLAFVFLIG APVAQIFASLTVWLAGMKGSSSILLALILGAMISFDMGGPVNKVAFLFGSAMIGEGNY EIMGPIAVAICIPPIGLGIATFLGKRKFEASQREMGKAAFTMGLFGITEGAIPFAAQD PLRVIPSIMAGSMTGSVIAMIGNVGDRVAHGGPIVAVLGAVDHVLMFFIAVIAGSLVT ALFVNVLKKDITASPVLSETAPTSAPSEAAAANEIKQPIQSQKAEMSEFKKLTDIISP ELIEPNLSGETSDDIIDELIQKLSRRGALLSESGFKQAILNREQQGTTAIGMNIAIPH GKSEAVREPSVAFGIKRSGVDWNSLDGSEAKLIFMIAVPKESGGNQHLKILQMLSRKL MDDNYRERLLSVQTTEEAYKLLEEIE*" /label="manP CDS" gene 1222296..1224248 /gene="manP" /locus_tag="BSU_12010" /old_locus_tag="BSU12010" /label="manP gene" CDS 1224263..1225210 /gene="manA" /locus_tag="BSU_12020" /old_locus_tag="BSU12020" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 7934877, 20862359, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 7934877, 20862359, 23551403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannose-6 phosphate isomerase; cupin family" /protein_id="NP_389084.1" /db_xref="EnsemblGenomes-Gn:BSU12020" /db_xref="EnsemblGenomes-Tr:CAB13059" /db_xref="GOA:O31646" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13177" /db_xref="UniProtKB/Swiss-Prot:O31646" /translation="MTTEPLFFKPVFKERIWGGTALADFGYTIPSQRTGECWAFAAHQ NGQSVVQNGMYKGFTLSELWEHHRHLFGQLEGDRFPLLTKILDADQDLSVQVHPNDEY ANIHENGELGKTECWYIIDCQKDAEIIYGHNATTKEELTTMIERGEWDELLRRVKVKP GDFFYVPSGTVHAIGKGILALETQQNSDTTYRLYDYDRKDAEGKLRELHLKKSIEVIE VPSIPERHTVHHEQIEDLLTTTLIECAYFSVGKWNLSGSASLKQQKPFLLISVIEGEG RMISGEYVYPFKKGDHMLLPYGLGEFKLEGYAECIVSHL*" /label="manA CDS" gene 1224263..1225210 /gene="manA" /locus_tag="BSU_12020" /old_locus_tag="BSU12020" /label="manA gene" S_feature 1225211..1225309 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1225284..1225290 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1225305..1225324 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1225311..1225379 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1225311 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="upshifts" CDS 1225380..1225862 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" /label="yjdF CDS" gene 1225380..1225862 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /label="yjdF gene" downshifts 1225842 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1225908..1226414) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" /label="yjdG CDS" gene complement(1225908..1226414) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /label="yjdG gene" downshifts complement(1225932) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" /label="downshifts" misc_feature complement(1226439..1226458) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1226445) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1226447..1226632) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1226633..1227028) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" /label="yjdH CDS" gene complement(1226633..1227028) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /label="yjdH gene" promotor_-10 complement(1227051..1227069) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1227064) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1227066..1227766) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1227084..1227089) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1227172..1227179 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1227193..1227212 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1227204 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="upshifts" CDS 1227257..1227736 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " /label="trnE CDS" gene 1227257..1227736 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /label="trnE gene" downshifts 1227735 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1227776..1227970) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" /label="yjzH CDS" gene complement(1227776..1227970) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /label="yjzH gene" downshifts complement(1227811) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1227984..1227999) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1228000) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1228011..1228020) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1228136..1228465) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" /label="yjdJ CDS" gene complement(1228136..1228465) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /label="yjdJ gene" promotor_-10 complement(1228502..1228521) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1228515) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1228517..1229084) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1228536..1228541) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1228569..1228573 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1228589..1228608 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1228593..1229094 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1228593 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1229085..1230074) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" /label="ctaO CDS" gene complement(1229085..1230074) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /label="ctaO gene" promotor_-10 complement(1230075..1230094) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1230078) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="upshifts" promotor_-35 complement(1230108..1230113) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1230197..1230445) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" /label="cotT CDS" gene complement(1230197..1230445) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /label="cotT gene" downshifts complement(1230207) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1230441..1230445 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1230454..1230468 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1230463 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1230470..1230489) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1230479) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1230503..1230512) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1230560..1230567 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1230574..1230593) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1230581..1230600 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1230583) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="upshifts" upshifts 1230594 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1230595..1230698 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1230607..1230614) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1230699..1232102 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" /label="pdaC CDS" gene 1230699..1232102 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /label="pdaC gene" downshifts 1232091 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1232142..1232615) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" /label="yjfA CDS" gene complement(1232142..1232615) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /label="yjfA gene" downshifts complement(1232146) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1232637..1232655) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1232655) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1232670..1232675) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1232740..1232907) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" /label="yjfB CDS" gene complement(1232740..1232907) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /label="yjfB gene" downshifts complement(1232743) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1232919..1232937) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1232928) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1232950..1232957) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1233034..1233933 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" /label="yjfC CDS" gene 1233034..1233933 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /label="yjfC gene" CDS complement(1233942..1234340) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" /label="yjgA CDS" gene complement(1233942..1234340) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /label="yjgA gene" downshifts complement(1233972) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1234369..1234388) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1234388) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1234403..1234410) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1234441..1235016) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" /label="yjgB CDS" gene complement(1234441..1235016) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /label="yjgB gene" downshifts complement(1234456) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1235035..1235053) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1235050) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1235067..1235073) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1235091..1235097 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1235112..1235130 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1235113 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="upshifts" CDS 1235162..1238119 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" /label="yjgC CDS" gene 1235162..1238119 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /label="yjgC gene" CDS 1238112..1238672 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" /label="yjgD CDS" gene 1238112..1238672 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /label="yjgD gene" downshifts 1238665 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" /label="downshifts" S_feature 1238710..1238828 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1238806..1238809 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1238825..1238844 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1238830 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1238869..1239510 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" /label="yjhA CDS" gene 1238869..1239510 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /label="yjhA gene" downshifts complement(1238878) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" /label="downshifts" downshifts 1239483 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 1239589..1240215 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" /label="yjhB CDS" gene 1239589..1240215 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /label="yjhB gene" downshifts 1240217 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" /label="downshifts" downshifts complement(1240220) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(1240246..1240524) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" /label="yjiA CDS" gene complement(1240246..1240524) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /label="yjiA gene" downshifts complement(1240264) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1240553..1240564) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1240566..1240572) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1240572) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1240574..1240990) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1240742 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1240743..1240762 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1240760..1240914 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1240915..1242105 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" /label="cypE CDS" gene 1240915..1242105 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /label="cypE gene" promotor_-10 complement(1240988..1241007) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1240990) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1241021..1241030) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1242128..1243306 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" /label="ppuG CDS" gene 1242128..1243306 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /label="ppuG gene" CDS complement(1243347..1243535) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" /label="yjzI CDS" gene complement(1243347..1243535) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /label="yjzI gene" downshifts complement(1243363) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1243561..1243580) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1243564) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1243594..1243600) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1243622..1243629 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1243644..1243663 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1243655 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1243670..1243689) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1243674) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1243704..1243711) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1243709..1244521 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" /label="yjjA CDS" gene 1243709..1244521 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /label="yjjA gene" downshifts 1244500 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1244567..1245319) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" /label="yjkA CDS" gene complement(1244567..1245319) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /label="yjkA gene" downshifts complement(1244576) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" /label="downshifts" CDS complement(1245319..1246071) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" /label="yjkB CDS" gene complement(1245319..1246071) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /label="yjkB gene" CDS complement(1246191..1247165) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" /label="yjlA CDS" gene complement(1246191..1247165) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /label="yjlA gene" downshifts complement(1246226) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1247186..1247205) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1247212) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1247214..1249720) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1247220..1247227) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1247248..1247254 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1247269..1247287 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1247272 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1247297..1247794 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" /label="yjlB CDS" gene 1247297..1247794 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /label="yjlB gene" S_feature 1247795..1247908 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1247888..1247892 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1247908..1247927 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1247910..1248182 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1247910 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1248183..1248605 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" /label="yjlC CDS" gene 1248183..1248605 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /label="yjlC gene" CDS 1248645..1249823 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" /label="ndh CDS" gene 1248645..1249823 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /label="ndh gene" promotor_no_box 1249654..1249754 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1249712..1249730) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1249714 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1249720) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1249742..1249750) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1249822 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 1249931..1249938 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1249953..1249972 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1249978 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="upshifts" CDS 1250021..1251442 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" /label="uxaC CDS" gene 1250021..1251442 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /label="uxaC gene" CDS 1251510..1252889 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" /label="exuM CDS" gene 1251510..1252889 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /label="exuM gene" promotor_-10 complement(1252029..1252048) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1252034) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1252062..1252069) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1252914 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1252924..1252931 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1252926..1252993 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1252994..1254007 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" /label="yjmC CDS" gene 1252994..1254007 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /label="yjmC gene" CDS 1254013..1255032 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" /label="yjmD CDS" gene 1254013..1255032 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /label="yjmD gene" CDS 1255057..1256136 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" /label="uxuA CDS" gene 1255057..1256136 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /label="uxuA gene" CDS 1256133..1256969 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" /label="uxuB CDS" gene 1256133..1256969 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /label="uxuB gene" CDS 1257017..1258285 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" /label="exuT CDS" gene 1257017..1258285 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /label="exuT gene" promotor_-35 1258229..1258232 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1258248..1258252 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1258250 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1258318..1258337 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1258318 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" CDS 1258373..1259374 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " /label="exuR CDS" gene 1258373..1259374 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /label="exuR gene" promotor_no_box complement(1259056..1259156) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1259096) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1259350 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1259451..1260893 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" /label="uxaB CDS" gene 1259451..1260893 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /label="uxaB gene" CDS 1260890..1262383 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" /label="uxaA CDS" gene 1260890..1262383 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /label="uxaA gene" CDS complement(1262422..1263186) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /modified_by="User" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGGIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" /label="Delta6_BSU_12400_SNPvariant" gene complement(1262422..1263186) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /modified_by="User" /label="Delta6_BSU_12400_SNPvariant" downshifts complement(1262441) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" Polymorphism join(1262954,1262956) /Source="geneious" /ID="SNP_BsDelta6_1313384_1313384" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="S -> G" /CDS_Position=232 /Change="T -> C" /Codon_Change="AGT -> GGT" /Coverage=150 /locus_tag="BSU_12400" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=149 /comment="Delta6_BSU_12400_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" SCAR join(1263213,1263220) /created_by="User" /modified_by="User" /label="TF8A" N_region 1263214..1263219 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1263222..1263542 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1263222..1263542 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1263551 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" S_feature complement(1263560..1263763) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1263579..1263716) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" /label="spoIISC CDS" gene complement(1263579..1263716) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /label="spoIISC gene" downshifts complement(1263603) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1263802..1263972) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" /label="spoIISB CDS" gene complement(1263802..1263972) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /label="spoIISB gene" downshifts complement(1263808) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" /label="downshifts" CDS complement(1263972..1264718) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" /label="spoIISA CDS" gene complement(1263972..1264718) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /label="spoIISA gene" promotor_-10 complement(1264553..1264572) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1264570) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1264588..1264595) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1264744..1264762) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1264757) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1264778..1264783) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1264828..1265829) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " /label="pitB CDS" gene complement(1264828..1265829) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /label="pitB gene" downshifts complement(1264857) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1265842..1266459) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" /label="ykaA CDS" gene complement(1265842..1266459) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /label="ykaA gene" promotor_-10 complement(1266495..1266514) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1266497) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1266499..1266596) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1266530..1266534) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1266576..1266595) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1266596) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1266610..1266617) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1266641..1266660) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1266653) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1266735..1268051) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" /label="steT CDS" gene complement(1266735..1268051) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /label="steT gene" downshifts complement(1266750) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1268098..1268117) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1268114) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="upshifts" promotor_-35 complement(1268132..1268135) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1268334..1268341 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1268356..1268375 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1268368..1268439 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1268368 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="upshifts" CDS 1268440..1269390 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" /label="mhqA CDS" gene 1268440..1269390 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /label="mhqA gene" downshifts 1269378 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 1269491..1269637 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" /label="hypothetical protein CDS" gene 1269491..1269637 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /label="gene" CDS 1269645..1271795 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" /label="ykcB CDS" gene 1269645..1271795 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /label="ykcB gene" promotor_no_box 1270534..1270634 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1270594 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1270682 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1271807..1272778 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" /label="ykcC CDS" gene 1271807..1272778 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /label="ykcC gene" S_feature complement(1272135..1272776) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1272821) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" /label="downshifts" S_feature complement(1272846..1273212) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1272889) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1273192..1273207) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1273212) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1273219..1273228) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1273296..1274645) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " /label="htrA CDS" gene complement(1273296..1274645) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /label="htrA gene" downshifts complement(1273310) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1274685..1274692 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1274697..1274716) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1274705 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="upshifts" promotor_-10 1274707..1274726 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1274715) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1274717..1274799) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1274727..1274734) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1274756..1274762 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1274777..1274796 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1274780 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1274782..1274801) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1274799) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1274814..1275632 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" /label="proCC CDS" gene 1274814..1275632 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /label="proCC gene" promotor_-35 complement(1274817..1274820) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1275610 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1275689..1275696 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1275711..1275730 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1275715 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1275761..1276585 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" /label="dppA CDS" gene 1275761..1276585 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /label="dppA gene" CDS 1276602..1277528 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" /label="dppB CDS" gene 1276602..1277528 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /label="dppB gene" CDS 1277534..1278496 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" /label="dppC CDS" gene 1277534..1278496 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /label="dppC gene" promotor_-35 1278228..1278233 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1278249..1278267 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1278250 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1278501..1279508 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" /label="dppD CDS" gene 1278501..1279508 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /label="dppD gene" CDS 1279511..1281160 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" /label="dppE CDS" gene 1279511..1281160 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /label="dppE gene" downshifts 1281154 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" /label="downshifts" CDS 1281248..1282207 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" /label="ldcA CDS" gene 1281248..1282207 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /label="ldcA gene" CDS 1282204..1283304 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" /label="aeeB CDS" gene 1282204..1283304 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /label="aeeB gene" CDS 1283301..1284191 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" /label="eepC CDS" gene 1283301..1284191 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /label="eepC gene" CDS 1284204..1285193 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" /label="ykfD CDS" gene 1284204..1285193 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /label="ykfD gene" S_feature complement(1284487..1285214) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1285183 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" S_feature 1285228..1286396 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1285236..1286285) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" /label="pgl CDS" gene complement(1285236..1286285) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /label="pgl gene" downshifts complement(1285259) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1286312..1286331) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1286323) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1286346..1286353) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1286375..1287235) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" /label="ddaH CDS" gene complement(1286375..1287235) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /label="ddaH gene" promotor_-10 complement(1287260..1287278) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1287277) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1287294..1287300) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1287309..1287316 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1287330..1287349 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1287337 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="upshifts" CDS 1287395..1287913 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" /label="ykhA CDS" gene 1287395..1287913 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /label="ykhA gene" downshifts 1287904 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" /label="downshifts" promotor_-35 1287978..1287984 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1287996..1288102 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1287996 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="upshifts" promotor_-10 1287998..1288009 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1288077..1288080 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1288096..1288115 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1288104 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1288152..1289351 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" /label="hmpA CDS" gene 1288152..1289351 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /label="hmpA gene" downshifts 1289340 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1289385..1289756 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1289428..1289652) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" /label="ykzH CDS" gene complement(1289428..1289652) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /label="ykzH gene" promotor_-35 1289732..1289738 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1289752..1289763 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1289758 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1289797..1290528 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" /label="ykjA CDS" gene 1289797..1290528 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /label="ykjA gene" downshifts 1290506 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1290567..1290575 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1290586..1290604 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1290594 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1290620..1291147 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" /label="ykkA CDS" gene 1290620..1291147 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /label="ykkA gene" CDS 1291137..1291655 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" /label="ykkB CDS" gene 1291137..1291655 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /label="ykkB gene" promotor_-35 1291649..1291656 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1291670..1291689 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1291673 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="upshifts" misc_RNA 1291688..1291799 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" /label="gdwA RNA" gene 1291688..1291799 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /label="gdwA gene" downshifts 1291762 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" /label="downshifts" CDS 1291877..1292215 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" /label="gdnC CDS" gene 1291877..1292215 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /label="gdnC gene" CDS 1292215..1292532 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" /label="gdnD CDS" gene 1292215..1292532 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /label="gdnD gene" promotor_-35 1292532..1292535 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1292551..1292570 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1292563 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1292603..1293505 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" /label="purU CDS" gene 1292603..1293505 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /label="purU gene" downshifts 1293496 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" /label="downshifts" promotor_-35 1293552..1293558 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1293564 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1293572..1293591 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1293593..1293803 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" /label="pswB RNA" gene 1293593..1293803 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /label="pswB gene" downshifts 1293761 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1293856..1294953 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" /label="proB CDS" gene 1293856..1294953 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /label="proB gene" promotor_-35 1294043..1294045 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1294047..1294051 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1294047 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1294965..1296212 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" /label="proA CDS" gene 1294965..1296212 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /label="proA gene" downshifts 1296203 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1296274..1296281 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1296296..1296315 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1296305 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1296338..1296763 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" /label="ohrA CDS" gene 1296338..1296763 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /label="ohrA gene" downshifts 1296752 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1296794..1297237) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" /label="ohrR CDS" gene complement(1296794..1297237) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /label="ohrR gene" downshifts complement(1296828) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1297264..1297283) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1297270) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1297298..1297301) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1297319..1297325 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1297339..1297357 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1297345 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="upshifts" CDS 1297380..1297790 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" /label="ohrB CDS" gene 1297380..1297790 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /label="ohrB gene" downshifts 1297768 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" /label="downshifts" CDS 1297817..1297987 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" /label="ykzN CDS" gene 1297817..1297987 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /label="ykzN gene" S_feature 1297988..1298665 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1298037..1298507) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" /label="guaN CDS" gene complement(1298037..1298507) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /label="guaN gene" downshifts complement(1298061) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1298529..1298548) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1298545) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1298547..1298654) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1298564..1298567) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1298623 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1298680..1300968) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" /label="metE CDS" gene complement(1298680..1300968) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /label="metE gene" downshifts complement(1298699) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature complement(1300969..1301031) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1300991..1301091) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1301031) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1301096..1301251) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" /label="mswB RNA" gene complement(1301096..1301251) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /label="mswB gene" downshifts complement(1301097) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1301284..1301303) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1301296) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1301298..1301383) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1301319..1301326) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1301384..1302343) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" /label="ispA CDS" gene complement(1301384..1302343) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /label="ispA gene" S_feature complement(1302344..1302395) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1302388..1302407) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1302400) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1302421..1302427) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1302512..1302515 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1302528 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1302531..1302550 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1302566..1303399 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" /label="rsbRB CDS" gene 1302566..1303399 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /label="rsbRB gene" downshifts 1303375 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1303430..1304194) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" /label="thiX CDS" gene complement(1303430..1304194) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /label="thiX gene" downshifts complement(1303451) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1304169..1305812) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" /label="thiW CDS" gene complement(1304169..1305812) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /label="thiW gene" CDS complement(1305799..1306398) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" /label="thiV CDS" gene complement(1305799..1306398) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /label="thiV gene" CDS complement(1306400..1307002) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" /label="thiU CDS" gene complement(1306400..1307002) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /label="thiU gene" downshifts complement(1307080) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1307099..1307211) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswB RNA" gene complement(1307099..1307211) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /label="tswB gene" promotor_-35 1307212..1307215 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1307226..1307245) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1307231..1307250 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1307242 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1307247) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1307260..1307267) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1307313..1307999 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" /label="ykoG CDS" gene 1307313..1307999 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /label="ykoG gene" CDS 1308003..1309367 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" /label="ykoH CDS" gene 1308003..1309367 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /label="ykoH gene" CDS 1309364..1310044 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" /label="ykoI CDS" gene 1309364..1310044 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /label="ykoI gene" promotor_-35 1310073..1310078 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1310094..1310112 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1310097 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1310136..1310648 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" /label="ykoJ CDS" gene 1310136..1310648 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /label="ykoJ gene" downshifts 1310634 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 1310679..1310685 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1310699..1310710 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1310700 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1310731..1310868 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" /label="ykzD CDS" gene 1310731..1310868 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /label="ykzD gene" downshifts 1310841 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1310927..1310934 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1310948..1310967 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1310950..1311269 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1310950 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1310982..1311135 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="swmG RNA" gene 1310982..1311135 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /label="swmG gene" promotor_-35 1311247..1311256 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1311269..1311288 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1311271..1311372 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1311271 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" CDS 1311373..1312728 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" /label="mgtE CDS" gene 1311373..1312728 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /label="mgtE gene" downshifts 1312719 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1312771..1313103) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" /label="tnrA CDS" gene complement(1312771..1313103) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /label="tnrA gene" promotor_-10 complement(1313119..1313138) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1313129) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1313131..1313519) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1313154..1313159) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1313191..1313291 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1313251 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="upshifts" CDS 1313298..1313453 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" /label="ykzB CDS" gene 1313298..1313453 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /label="ykzB gene" promotor_-35 1313462..1313469 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1313476..1313493 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1313493 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1313504..1313523) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1313519) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1313537..1313543) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1313541..1313723 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" /label="ykoL CDS" gene 1313541..1313723 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /label="ykoL gene" downshifts 1313691 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1313748..1313756 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1313767..1313785 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1313773..1313855 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1313773 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" CDS 1313856..1314320 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" /label="ykoM CDS" gene 1313856..1314320 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /label="ykoM gene" downshifts 1314305 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" /label="downshifts" CDS complement(1314335..1315456) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" /label="ykoN CDS" gene complement(1314335..1315456) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /label="ykoN gene" promotor_-35 1314744..1314752 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1314766..1314785 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1314769..1315547 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1314769 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1315485..1315496) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1315505) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1315511..1315517) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1315548..1316099 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" /label="ykoP CDS" gene 1315548..1316099 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /label="ykoP gene" downshifts 1316067 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(1316127..1316939) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" /label="ykoQ CDS" gene complement(1316127..1316939) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /label="ykoQ gene" promotor_-10 complement(1316899..1316918) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1316913) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1316932..1316937) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1317040..1317046 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1317057..1317131 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1317057 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1317060..1317071 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1317132..1318826 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" /label="ykoS CDS" gene 1317132..1318826 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /label="ykoS gene" CDS 1318839..1319852 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" /label="ykoT CDS" gene 1318839..1319852 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /label="ykoT gene" downshifts 1319837 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(1319878..1321713) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" /label="ligD CDS" gene complement(1319878..1321713) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /label="ligD gene" downshifts complement(1319927) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1321717..1322652) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" /label="ligV CDS" gene complement(1321717..1322652) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /label="ligV gene" promotor_-10 complement(1322623..1322634) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1322633) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1322649..1322655) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1322689..1325091) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" /label="dgcW CDS" gene complement(1322689..1325091) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /label="dgcW gene" downshifts complement(1322721) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1324939..1325141) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1325130..1325148) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1325141) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1325162..1325169) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1325208..1325215 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1325229..1325248 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1325241 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="upshifts" CDS 1325272..1325937 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" /label="ykoX CDS" gene 1325272..1325937 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /label="ykoX gene" promotor_-10 complement(1325806..1325825) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1325823) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1325839..1325848) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1325932..1325939 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1325954..1325973 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1325967 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1325993..1326126 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="mnrW RNA" gene 1325993..1326126 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /label="mnrW gene" CDS 1326014..1326988 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" /label="ykoY CDS" gene 1326014..1326988 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /label="ykoY gene" downshifts 1326077 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" /label="downshifts" downshifts 1326976 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1327098..1327106 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1327120..1327128 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1327130 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="upshifts" S_feature 1327133..1327219 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1327192..1327199 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1327213..1327232 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1327221 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="upshifts" CDS 1327252..1328007 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" /label="sigI CDS" gene 1327252..1328007 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /label="sigI gene" CDS 1328004..1329149 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" /label="rsgI CDS" gene 1328004..1329149 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /label="rsgI gene" S_feature 1329150..1330309 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1329160..1329354) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" /label="sspD CDS" gene complement(1329160..1329354) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /label="sspD gene" downshifts complement(1329167) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1329397..1329408) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1329407) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1329423..1329429) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1329485..1330186) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" /label="htpK CDS" gene complement(1329485..1330186) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /label="htpK gene" downshifts complement(1329519) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1330187..1330267) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1330259..1330278) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1330267) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1330283..1330290 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1330292..1330299) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1330304..1330323 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1330311 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="upshifts" CDS 1330357..1331253 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" /label="htpX CDS" gene 1330357..1331253 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /label="htpX gene" downshifts 1331247 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1331358..1331362 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1331378..1331397 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1331382 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="upshifts" CDS 1331427..1332776 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " /label="ktrD CDS" gene 1331427..1332776 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /label="ktrD gene" downshifts 1332764 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1332825..1332831 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1332845..1332856 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1332853..1332920 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1332853 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1332921..1333076 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" /label="ykzP CDS" gene 1332921..1333076 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /label="ykzP gene" CDS 1333079..1333255 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" /label="ykzE CDS" gene 1333079..1333255 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /label="ykzE gene" promotor_no_box 1333145..1333245 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1333205 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1333251 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1333298..1334320) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" /label="ykrP CDS" gene complement(1333298..1334320) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /label="ykrP gene" downshifts complement(1333321) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1334365..1334384) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1334381) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1334396..1334402) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1334509..1334517 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1334525 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1334528..1334546 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1334573..1336789 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" /label="kinE CDS" gene 1334573..1336789 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /label="kinE gene" S_feature complement(1336564..1337504) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1336642..1336649 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1336664..1336683 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1336666 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="upshifts" CDS 1336786..1337283 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" /label="ogt CDS" gene 1336786..1337283 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /label="ogt gene" S_feature 1337284..1337523 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1337373..1337498 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" /label="hypothetical protein CDS" gene 1337373..1337498 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /label="gene" downshifts 1337491 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1337532..1338593) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" /label="mtnA CDS" gene complement(1337532..1338593) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /label="mtnA gene" downshifts complement(1337549) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(1338601..1339794) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" /label="mtnK CDS" gene complement(1338601..1339794) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /label="mtnK gene" downshifts 1338661 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts complement(1339881) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1339887..1340043) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" /label="mswC RNA" gene complement(1339887..1340043) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /label="mswC gene" promotor_-10 complement(1340078..1340097) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1340079) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1340113..1340120) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1340123..1340126 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1340127..1340906) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" /label="mtnU CDS" gene complement(1340127..1340906) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /label="mtnU gene" promotor_-10 1340142..1340161 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1340151 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1340599..1340606 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1340619..1340638 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1340634 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="upshifts" S_feature 1340641..1340958 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1340928..1340935 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1340936..1340955) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1340950..1340969 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1340950) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" upshifts 1340960 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1340971..1340978) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1341001..1342197 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" /label="mtnE CDS" gene 1341001..1342197 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /label="mtnE gene" promotor_-35 1342179..1342186 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1342201..1342220 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1342220 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1342236..1342336 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" /label="mswD RNA" gene 1342236..1342336 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /label="mswD gene" downshifts 1342335 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS 1342421..1343638 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" /label="mtnW CDS" gene 1342421..1343638 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /label="mtnW gene" CDS 1343635..1344342 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" /label="mtnX CDS" gene 1343635..1344342 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /label="mtnX gene" CDS 1344300..1344929 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" /label="mtnB CDS" gene 1344300..1344929 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /label="mtnB gene" CDS 1344944..1345480 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" /label="mtnD CDS" gene 1344944..1345480 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /label="mtnD gene" S_feature complement(1345327..1345520) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1345480 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1345521..1345841) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" /label="ykvA CDS" gene complement(1345521..1345841) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /label="ykvA gene" downshifts complement(1345579) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(1345842..1345931) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1345867..1345873 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1345888..1345906 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1345898 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" S_feature 1345899..1345983 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1345913..1345932) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1345930) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1345947..1345950) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1345957..1345964 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1345979..1345998 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1345985..1346043 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1345985 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1346041) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1346044..1346301 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" /label="spo0E CDS" gene 1346044..1346301 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /label="spo0E gene" downshifts 1346295 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS 1346387..1346818 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" /label="eag CDS" gene 1346387..1346818 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /label="eag gene" CDS complement(1346846..1348366) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /EC_number="2.7.13.3" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine kinase phosphorylating Spo0A" /protein_id="NP_389249.1" /db_xref="EnsemblGenomes-Gn:BSU13660" /db_xref="EnsemblGenomes-Tr:CAB13239" /db_xref="GOA:O31671" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4JGO" /db_xref="PDB:4JGP" /db_xref="PDB:4JGQ" /db_xref="PDB:4JGR" /db_xref="SubtiList:BG13309" /db_xref="UniProtKB/Swiss-Prot:O31671" /translation="MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIA AEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPR FSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFT ICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAE DQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQ TQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIE QEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTE QPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQE MLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS*" /label="kinD CDS" gene complement(1346846..1348366) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /label="kinD gene" downshifts complement(1346858) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1347567..1347573 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1347587..1347598 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1347593 /Source="Nicolas_upshifts" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1348374..1348393) /Source="Nicolas_upshift_promotors" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1348395) /Source="Nicolas_upshifts" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1348493..1348500 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1348515..1348534 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1348517 /Source="Nicolas_upshifts" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="upshifts" CDS 1348559..1348996 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17725564, 17962296, 18282125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17725564, 17962296, 18282125; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family)" /protein_id="NP_389250.1" /db_xref="EnsemblGenomes-Gn:BSU13670" /db_xref="EnsemblGenomes-Tr:CAB13240" /db_xref="GOA:O31672" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13310" /db_xref="UniProtKB/Swiss-Prot:O31672" /translation="MTEKSLKLFIVLSRAYRSINDHMNKHIHKHGLNPTEFAVLELLY HKGDQPLQQIGDKILLASGSITYVVDKLEQKELLIRKASPTDRRVTFAQITEKGIGLL NDIFPDHAAEIDEMISVLSEEEVEMCTEMLKRVGLNAKQFHNK*" /label="mhqR CDS" gene 1348559..1348996 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /label="mhqR gene" downshifts 1348979 /Source="Nicolas_upshifts" /id="D754" /incds=0 /nref=210 /ntot=257 /MaxReadThrough="1.20686" /MaxDrop="5.47215" /score="1.59181784" /energy="-8.9" /TU="U1110" /idTUdmin="U1110" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1349036..1349821) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein B; MotB component of the H+-coupled stator flagellum complex" /protein_id="NP_389251.1" /db_xref="EnsemblGenomes-Gn:BSU13680" /db_xref="EnsemblGenomes-Tr:CAB13241" /db_xref="GOA:P28612" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10689" /db_xref="UniProtKB/Swiss-Prot:P28612" /translation="MARKKKKKHEDEHVDESWLVPYADILTLLLALFIVLYASSSIDA AKFQMLSKSFNEVFTGGTGVLDYSSVTPPENESDGIDEVKKEKEEKEKNKKEKEKAAD QEELENVKSQVEKFIKDKKLEHQLETKMTSEGLLITIKDSIFFDSGKATIRKEDVPLA KEISNLLVINPPRNIIISGHTDNMPIKNSEFQSNWHLSVMRAVNFMGLLIENPKLDAK VFSAKGYGEYKPVASNKTAEGRSKNRRVEVLILPRGAAETNEK*" /label="motB CDS" gene complement(1349036..1349821) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /label="motB gene" downshifts complement(1349055) /Source="Nicolas_upshifts" /id="D755" /incds=0 /nref=224 /ntot=246 /MaxReadThrough="3.05351" /MaxDrop="6.69306" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(1349517) /Source="Nicolas_upshifts" /id="D756" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="8.03566" /MaxDrop="4.69358" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1349793..1350605) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein A; MotA component of the H+-coupled stator flagellum complex" /protein_id="NP_389252.1" /db_xref="EnsemblGenomes-Gn:BSU13690" /db_xref="EnsemblGenomes-Tr:CAB13242" /db_xref="GOA:P28611" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10688" /db_xref="UniProtKB/Swiss-Prot:P28611" /translation="MDKTSLIGIILAFVALSVGMVLKGVSFSALANPAAILIIIAGTI SAVVIAFPTKEIKKVPTLFRVLFKENKQLTIEELIPMFSEWAQLARREGLLALEASIE DVDDAFLKNGLSMAVDGQSAEFIRDIMTEEVEAMEDRHQAGAAIFTQAGTYAPTLGVL GAVIGLIAALSHMDNTDELGHAISAAFVATLLGIFTGYVLWHPFANKLKRKSKQEVKL REVMIEGVLSVLEGQAPKVIEQKLLMYLPAKDRLKFAEQGEAQNGEKKEEEA*" /label="motA CDS" gene complement(1349793..1350605) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /label="motA gene" promotor_-10 complement(1350636..1350654) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1350652) /Source="Nicolas_upshifts" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1350668..1350675) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1350743..1350965) /Source="Nicolas_S_feature" /locus_tag="new_1435383_1435605_c" /HighExp="Diami, dia15, dia5, Heat, Etha, LPhT, H2O2, C30, G135, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.93062599999999995" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S491" downshifts complement(1350775) /Source="Nicolas_upshifts" /id="D757" /incds=0 /nref=5 /ntot=12 /MaxReadThrough="0.48394" /MaxDrop="4.60081" /score="30.9355071" /energy="-15.4" /TU="NA" /idTUdmin="U1112" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1350988..1353087) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" /label="clpE CDS" gene complement(1350988..1353087) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /label="clpE gene" downshifts complement(1351010) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" /label="downshifts" S_feature complement(1353088..1353338) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1353298..1353398) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1353338) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1353374..1353379 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1353389 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1353395..1353413 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1353452..1354495 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" /label="ykvI CDS" gene 1353452..1354495 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /label="ykvI gene" S_feature 1354496..1354587 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1354564..1354568 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1354585..1354604 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1354589 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1354634..1354678 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" /label="qswA RNA" gene 1354634..1354678 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /label="qswA gene" downshifts 1354655 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1354700..1354807 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1354808..1355467 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" /label="queC CDS" gene 1354808..1355467 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /label="queC gene" CDS 1355460..1355909 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" /label="queD CDS" gene 1355460..1355909 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /label="queD gene" CDS 1355902..1356633 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" /label="queE CDS" gene 1355902..1356633 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /label="queE gene" CDS 1356651..1357148 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" /label="queF CDS" gene 1356651..1357148 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /label="queF gene" S_feature 1357149..1357425 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1357383 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1357393) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature complement(1357462..1357706) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1357503) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1357707..1358063) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" /label="ykvN CDS" gene complement(1357707..1358063) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /label="ykvN gene" misc_feature complement(1358094..1358113) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1358111) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1358148..1358166 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1358153 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="upshifts" CDS 1358232..1358978 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" /label="ykvO CDS" gene 1358232..1358978 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /label="ykvO gene" downshifts 1359033 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1359381..1359389 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1359403..1359422 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1359407 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="upshifts" CDS 1359459..1360658 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" /label="ykvP CDS" gene 1359459..1360658 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /label="ykvP gene" promotor_-35 1359541..1359547 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1359562..1359580 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1359568 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1360627..1360629 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1360649..1360667 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1360661 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1360674..1360901 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" /label="ykzQ CDS" gene 1360674..1360901 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /label="ykzQ gene" misc_feature complement(1360751..1360770) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1360759) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1360902..1360997 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1360998..1361696 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" /label="ykvQ CDS" gene 1360998..1361696 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo /label="ykvQ gene" S_feature complement(1361649..1362475) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1361677..1361928 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" /label="ykzR CDS" gene 1361677..1361928 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo /label="ykzR gene" misc_feature 1362178..1362193 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1362201..1362412 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1362201 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="upshifts" downshifts 1362377 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1362464..1362483) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1362486) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1362499..1362506) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1362551..1362558 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1362573..1362592 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1362575 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="upshifts" CDS 1362611..1362901 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" /label="ykvR CDS" gene 1362611..1362901 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /label="ykvR gene" S_feature complement(1362938..1363021) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1362981) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1363022..1363207) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" /label="ykvS CDS" gene complement(1363022..1363207) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /label="ykvS gene" promotor_-10 complement(1363240..1363259) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1363251) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1363253..1363597) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1363273..1363280) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1363306..1363311 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1363327..1363346 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1363334 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="upshifts" CDS 1363373..1363567 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" /label="ykzS CDS" gene 1363373..1363567 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /label="ykzS gene" downshifts 1363543 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1363588..1363606) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1363604) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1363623..1363628) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1363866..1364492 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" /label="ykvT CDS" gene 1363866..1364492 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /label="ykvT gene" downshifts 1364423 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1364549..1364554 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1364561 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1364570..1364588 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1364610..1365947 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" /label="ykvU CDS" gene 1364610..1365947 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /label="ykvU gene" CDS 1365998..1366495 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" /label="stoA CDS" gene 1365998..1366495 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /label="stoA gene" promotor_-35 1366344..1366350 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1366359 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1366365..1366383 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1366469 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1366590..1366596 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1366607..1366626 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1366619 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1366623..1366730 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1366731..1368644 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" /label="pfeT CDS" gene 1366731..1368644 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /label="pfeT gene" promotor_-10 complement(1366880..1366899) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1366897) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1366912..1366921) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1367048..1367067) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1367073) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1367081..1367087) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1368625 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1368701) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1368912..1368931) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1368921) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1368945..1368952) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1368996..1369015 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1369006 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="upshifts" CDS 1369051..1370142 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" /label="papB CDS" gene 1369051..1370142 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /label="papB gene" downshifts 1369791 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts 1370121 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" S_feature complement(1370155..1370373) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1370166..1370423 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1370360..1370379) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1370373) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1370395..1370402) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1370424..1371389 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" /label="ykvZ CDS" gene 1370424..1371389 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /label="ykvZ gene" promotor_-35 1371407..1371414 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1371429..1371448 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1371441 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="upshifts" CDS 1371452..1372318 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" /label="glcT CDS" gene 1371452..1372318 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /label="glcT gene" promotor_-35 1372173..1372177 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1372194..1372213 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1372202 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" downshifts 1372320 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_RNA 1372365..1372516 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" /label="gswA RNA" S_feature 1372365..1372516 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1372365..1372516 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /label="gswA gene" promotor_-35 1372494..1372500 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1372514..1372525 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1372518 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="upshifts" CDS 1372547..1374646 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" /label="ptsG CDS" gene 1372547..1374646 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /label="ptsG gene" promotor_-35 1374664..1374668 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1374684..1374703 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1374695 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1374744..1375010 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" /label="ptsH CDS" gene 1374744..1375010 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /label="ptsH gene" CDS 1375010..1376722 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" /label="ptsI CDS" gene 1375010..1376722 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /label="ptsI gene" downshifts 1376709 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-35 1376762..1376768 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1376783..1376794 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1376786 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1376813..1377052 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" /label="splA CDS" gene 1376813..1377052 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /label="splA gene" S_feature complement(1376833..1378172) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1377130..1378158 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" /label="splB CDS" gene 1377130..1378158 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /label="splB gene" downshifts 1378128 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1378173..1378853) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" /label="ykwB CDS" gene complement(1378173..1378853) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /label="ykwB gene" promotor_-10 complement(1378863..1378882) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1378886) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1378897..1378904) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1378938..1378945 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1378959..1378977 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1378965 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="upshifts" CDS 1378988..1380955 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" /label="mcpC CDS" gene 1378988..1380955 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /label="mcpC gene" misc_feature complement(1379428..1379443) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1379440) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1380926 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1380999..1381001 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1381017..1381036 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1381027 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1381069) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" /label="downshifts" CDS 1381093..1381959 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" /label="ohaC CDS" gene 1381093..1381959 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /label="ohaC gene" downshifts 1381939 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1381998..1382771) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" /label="ykwD CDS" gene complement(1381998..1382771) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /label="ykwD gene" downshifts complement(1382015) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1382803..1382822) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1382813) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1383046..1383065 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1383059 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1383061..1383164 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1383108..1385222 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" /label="pbpH CDS" gene 1383108..1385222 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /label="pbpH gene" promotor_-10 complement(1384401..1384419) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1384413) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1384435..1384440) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1385203 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" /label="downshifts" promotor_-35 1385295..1385303 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1385315..1385333 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1385327 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="upshifts" CDS 1385386..1387206 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" /label="kinA CDS" gene 1385386..1387206 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /label="kinA gene" CDS complement(1387217..1388398) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" /label="dapX CDS" gene complement(1387217..1388398) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /label="dapX gene" downshifts complement(1387251) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1388426..1388445) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1388442) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1388474..1388492) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1388486) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1388488..1388556) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1388507..1388512) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1388550..1388569) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1388556) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1388600..1388761) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" /label="ykzT CDS" gene complement(1388600..1388761) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /label="ykzT gene" promotor_-10 complement(1388784..1388803) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1388797) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1388817..1388824) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1388898..1388905 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1388917 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1388918..1388936 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1388965..1389876 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" /label="cheV CDS" gene 1388965..1389876 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /label="cheV gene" downshifts complement(1388970) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" /label="downshifts" promotor_-35 1389419..1389427 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1389441..1389458 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1389444 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1389861 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1389920..1390384) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" /label="kre CDS" gene complement(1389920..1390384) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /label="kre gene" downshifts complement(1389938) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1390414..1390433) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1390424) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1390448..1390455) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1390510..1391802) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" /label="ykuC CDS" gene complement(1390510..1391802) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /label="ykuC gene" downshifts complement(1390532) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1391826..1391845) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1391830) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="upshifts" promotor_-35 complement(1391861..1391865) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1391878..1392372) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" /label="ltdD CDS" gene complement(1391878..1392372) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /label="ltdD gene" promotor_-10 complement(1392388..1392407) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1392404) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1392421..1392430) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1392429..1393289) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" /label="ppeE CDS" gene complement(1392429..1393289) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /label="ppeE gene" misc_feature complement(1393310..1393329) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1393323) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="upshifts" promotor_-35 1393360..1393367 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1393383..1393402 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1393396 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="upshifts" CDS 1393432..1394196 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" /label="fadH CDS" gene 1393432..1394196 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /label="fadH gene" S_feature 1394197..1394345 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1394326..1394344 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1394347..1394496 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1394347 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1394394) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" /label="downshifts" CDS 1394497..1396227 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" /label="ykuG CDS" gene 1394497..1396227 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /label="ykuG gene" CDS 1396293..1396811 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" /label="ykzU CDS" gene 1396293..1396811 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /label="ykzU gene" downshifts 1396809 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 1396854..1396859 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1396872..1396891 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1396875 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="upshifts" CDS 1396907..1397455 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" /label="ykuH CDS" gene 1396907..1397455 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /label="ykuH gene" S_feature 1397456..1397607 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1397608..1398831 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" /label="ykuI CDS" gene 1397608..1398831 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /label="ykuI gene" promotor_-10 complement(1398794..1398812) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1398804) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1398810 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(1398827..1398832) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1398880..1398887 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1398899..1399000 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1398899 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1398902..1398921 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1398917..1399000 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" /label="fsrA RNA" gene 1398917..1399000 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /label="fsrA gene" downshifts 1398957 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 1399011..1399016 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1399031..1399315 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1399031 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1399033..1399051 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1399292..1399298 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1399312..1399323 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1399317..1399404 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1399317 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" misc_feature 1399393..1399412 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1399406 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1399477..1399716 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" /label="ykuJ CDS" gene 1399477..1399716 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /label="ykuJ gene" S_feature 1399717..1399825 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1399826..1400344 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" /label="ykuK CDS" gene 1399826..1400344 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /label="ykuK gene" promotor_-35 1400381..1400388 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1400402..1400421 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1400416 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1400478..1400675 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" /label="abbA CDS" gene 1400478..1400675 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /label="abbA gene" downshifts 1400671 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" /label="downshifts" S_feature 1400716..1400812 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1400813..1401256 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" /label="ykuL CDS" gene 1400813..1401256 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /label="ykuL gene" S_feature 1401257..1401364 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1401332..1401337 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1401352..1401371 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1401366 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1401405..1402286 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" /label="ccpC CDS" gene 1401405..1402286 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /label="ccpC gene" downshifts 1402265 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1402321..1402328 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1402343..1402362 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1402348 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1402398..1402874 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" /label="fldN CDS" gene 1402398..1402874 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /label="fldN gene" CDS 1402864..1403757 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" /label="ykuO CDS" gene 1402864..1403757 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /label="ykuO gene" CDS 1403773..1404228 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" /label="fldP CDS" gene 1403773..1404228 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /label="fldP gene" promotor_-10 complement(1404044..1404063) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1404057) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1404077..1404085) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1404222 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" /label="downshifts" promotor_-35 1404267..1404274 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1404288..1404307 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1404289 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1404333..1405043 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" /label="dapH CDS" gene 1404333..1405043 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /label="dapH gene" downshifts complement(1404342) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1404452..1404456) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1404452) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1405113..1406237 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" /label="dapI CDS" gene 1405113..1406237 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /label="dapI gene" promotor_-35 1406249..1406255 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1406269..1406280 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1406271 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1406275..1406289) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1406299..1406303) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1406299..1406544 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" /label="ykuS CDS" gene 1406299..1406544 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /label="ykuS gene" upshifts complement(1406300) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1406532 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1406577..1407527 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1406581..1407384) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" /label="mscT CDS" gene complement(1406581..1407384) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /label="mscT gene" downshifts complement(1406593) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1407435..1407454) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1407444) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1407468..1407475) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1407500..1407507 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1407522..1407541 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1407529..1407620 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1407529 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="upshifts" CDS 1407621..1408163 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" /label="ahpA CDS" gene 1407621..1408163 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /label="ahpA gene" CDS 1408235..1408681 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" /label="ykuV CDS" gene 1408235..1408681 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /label="ykuV gene" downshifts 1408689 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1409074..1409081 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1409094 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1409096..1409115 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1409147..1409722 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" /label="rok CDS" gene 1409147..1409722 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /label="rok gene" downshifts 1409700 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1409763..1410728) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" /label="sppO CDS" gene complement(1409763..1410728) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /label="sppO gene" downshifts complement(1409776) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1410072..1410073 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1410091..1410110 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1410097..1410821 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1410097 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1410749..1410767) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1410770) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1410782..1410787) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1410808..1410814 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1410824 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1410828..1410847 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1410865..1411464 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" /label="mobA CDS" gene 1410865..1411464 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /label="mobA gene" CDS 1411515..1412534 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" /label="moeB CDS" gene 1411515..1412534 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /label="moeB gene" CDS 1412552..1413844 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" /label="moeA CDS" gene 1412552..1413844 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /label="moeA gene" CDS 1413805..1414326 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" /label="mobB CDS" gene 1413805..1414326 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /label="mobB gene" CDS 1414326..1414799 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" /label="moaE CDS" gene 1414326..1414799 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /label="moaE gene" CDS 1414792..1415025 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" /label="moaD CDS" gene 1414792..1415025 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /label="moaD gene" downshifts 1415004 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1415070..1415075 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1415092..1415110 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1415100 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="upshifts" S_feature 1415112..1415198 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1415188..1415191 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1415200 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1415206..1415225 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1415249..1417006 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" /label="yknU CDS" gene 1415249..1417006 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /label="yknU gene" CDS 1417018..1418832 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" /label="yknV CDS" gene 1417018..1418832 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /label="yknV gene" promotor_-10 complement(1417455..1417474) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1417465) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1417489..1417496) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1418883..1418892 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1418904..1418919 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1418908 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="upshifts" CDS 1418942..1419637 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" /label="skiW CDS" gene 1418942..1419637 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /label="skiW gene" CDS 1419642..1420775 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" /label="skiX CDS" gene 1419642..1420775 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /label="skiX gene" CDS 1420776..1421468 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" /label="skiY CDS" gene 1420776..1421468 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /label="skiY gene" CDS 1421465..1422658 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" /label="skiZ CDS" gene 1421465..1422658 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /label="skiZ gene" downshifts 1422636 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" /label="downshifts" promotor_-35 1422707..1422713 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1422727..1422738 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1422735 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1422780..1422787 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1422802..1422821 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1422807..1422898 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1422807 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="upshifts" promotor_-35 1422862..1422869 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1422883..1422902 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1422900 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="upshifts" CDS 1422938..1423693 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" /label="fruR CDS" gene 1422938..1423693 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /label="fruR gene" upshifts complement(1423086) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1423088..1423090) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1423690..1424601 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" /label="fruK CDS" gene 1423690..1424601 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /label="fruK gene" CDS 1424616..1426523 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" /label="fruA CDS" gene 1424616..1426523 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /label="fruA gene" downshifts 1426508 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1426592..1426599 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1426610..1426629 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1426613 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="upshifts" CDS 1426668..1427249 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" /label="sipT CDS" gene 1426668..1427249 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /label="sipT gene" downshifts 1427234 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1427278 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1427283..1427552) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" /label="ykoA CDS" gene complement(1427283..1427552) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /label="ykoA gene" downshifts complement(1427288) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(1427553..1427618) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1427599..1427618) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1427618) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1427671..1427678 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1427689..1427708 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1427693 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="upshifts" CDS 1427733..1429355 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" /label="ykpA CDS" gene 1427733..1429355 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /label="ykpA gene" downshifts 1429343 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" /label="downshifts" CDS 1429412..1430323 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" /label="panE CDS" gene 1429412..1430323 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /label="panE gene" downshifts 1430328 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1430357..1431589) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" /label="ampS CDS" gene complement(1430357..1431589) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /label="ampS gene" downshifts complement(1430368) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1431607..1431626) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1431631) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1431641..1431646) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1431699..1431833) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" /label="ykpC CDS" gene complement(1431699..1431833) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /label="ykpC gene" downshifts complement(1431710) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1431855..1431873) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1431866) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1431868..1431933) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1431889..1431894) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1431934..1432941) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" /label="mreBH CDS" gene complement(1431934..1432941) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /label="mreBH gene" upshifts complement(1432987) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1432988..1432996) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1433010..1433018) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1433128..1433137 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1433149 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="upshifts" promotor_-10 1433150..1433165 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1433152..1433224 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1433225..1433503 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" /label="abhA CDS" gene 1433225..1433503 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /label="abhA gene" downshifts 1433501 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" /label="downshifts" S_feature complement(1433535..1435164) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1433546..1433650 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1433558) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1433632..1433639 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1433651..1433670 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1433652 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="upshifts" CDS 1433693..1434979 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" /label="kinC CDS" gene 1433693..1434979 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /label="kinC gene" CDS 1434995..1435828 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" /label="ykqA CDS" gene 1434995..1435828 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /label="ykqA gene" promotor_-10 complement(1435161..1435179) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1435176) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1435195..1435200) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1435891..1436556 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" /label="ktrC CDS" gene 1435891..1436556 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /label="ktrC gene" downshifts 1436540 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1436647..1436653 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1436668..1436687) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1436668..1436687 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1436680 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1436682) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1436711..1438444 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" /label="adeC CDS" gene 1436711..1438444 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /label="adeC gene" S_feature complement(1437839..1438443) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1438433 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1438478..1440145) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" /label="rnjA CDS" gene complement(1438478..1440145) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /label="rnjA gene" downshifts complement(1438488) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1440151..1440360) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" /label="rnpZA CDS" gene complement(1440151..1440360) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /label="rnpZA gene" promotor_-10 complement(1440397..1440416) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1440419) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1440421..1440598) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1440431..1440434) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1440599) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1440601..1440612) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1440626..1440632) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1440671..1440678 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1440692..1440711 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1440708 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1440746..1441519 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" /label="ykrA CDS" gene 1440746..1441519 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /label="ykrA gene" downshifts 1441490 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1441555..1442109) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" /label="defB CDS" gene complement(1441555..1442109) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /label="defB gene" downshifts complement(1441566) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1442131..1442150) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1442141) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1442165..1442172) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1442194 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1442218) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(1442219..1442377) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" /label="ykzV CDS" gene complement(1442219..1442377) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /label="ykzV gene" CDS complement(1442284..1442427) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" /label="putative antitoxin CDS" gene complement(1442284..1442427) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /label="gene" promotor_-35 1442373..1442377 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1442378..1442446) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1442387..1442401 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1442414 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1442430..1442449) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1442459) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1442462..1442471) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1442533..1442540 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1442554..1442573 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1442558 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1442591..1443262 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" /label="ykyA CDS" gene 1442591..1443262 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /label="ykyA gene" promotor_-35 1442930..1442939 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1442952..1442970 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1442964 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1443209 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 1443437..1443442 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1443459..1443478 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1443460..1443685 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1443460 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1443464..1443483) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1443480) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1443584..1443592) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1443590) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1443606..1443614) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1443686..1444801 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" /label="pdhA CDS" gene 1443686..1444801 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /label="pdhA gene" CDS 1444805..1445782 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" /label="pdhB CDS" gene 1444805..1445782 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /label="pdhB gene" S_feature 1445783..1445896 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1445817..1445836) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1445834) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1445851..1445854) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1445897..1447225 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" /label="pdhC CDS" gene 1445897..1447225 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /label="pdhC gene" promotor_-35 1446041..1446048 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1446063..1446082 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1446066 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="upshifts" CDS 1447230..1448642 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" /label="pdhD CDS" gene 1447230..1448642 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /label="pdhD gene" downshifts 1448639 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1448687..1449061) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" /label="slp CDS" gene complement(1448687..1449061) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /label="slp gene" downshifts complement(1448735) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(1449092..1449111) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1449102) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1449265..1449270 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1449286..1449304 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1449296 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="upshifts" S_feature 1449300..1449409 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1449332) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1449393..1449400 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1449411 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1449415..1449434 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1449430..1449640 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" /label="srrA RNA" gene 1449430..1449640 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /label="srrA gene" CDS 1449480..1449599 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" /label="rgpA CDS" gene 1449480..1449599 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /label="rgpA gene" downshifts complement(1449486) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts 1449586 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1449631..1451234 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1449639..1451111) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" /label="speA CDS" gene complement(1449639..1451111) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /label="speA gene" downshifts complement(1449657) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(1451112..1451207) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1451190..1451209) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1451207) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1451214..1451217 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1451224..1451231) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1451232..1451251 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1451236 /Source="Nicolas_upshifts" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="upshifts" CDS 1451296..1451562 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389347.1" /db_xref="EnsemblGenomes-Gn:BSU14640" /db_xref="EnsemblGenomes-Tr:CAB13337" /db_xref="InterPro:IPR007920" /db_xref="InterPro:IPR023324" /db_xref="SubtiList:BG11816" /db_xref="UniProtKB/Swiss-Prot:Q45497" /translation="MEYQYPMNEDWTTEEAVDVIAFFQQVELAYEKGADREELLKAYR RFKEIVPGKAEEKKLCGEFEEQSTYSPYRTVKQARESDHAKIKM*" /label="yktA CDS" gene 1451296..1451562 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /label="yktA gene" downshifts 1451544 /Source="Nicolas_upshifts" /id="D825" /incds=0 /nref=105 /ntot=250 /MaxReadThrough="2.62284" /MaxDrop="5.09814" /score="40.0811023" /energy="-16.1" /TU="NA" /idTUdmin="U1214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1451595..1452233) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25643072" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389348.1" /db_xref="EnsemblGenomes-Gn:BSU14650" /db_xref="EnsemblGenomes-Tr:CAB13338" /db_xref="InterPro:IPR009403" /db_xref="PDB:2A8E" /db_xref="SubtiList:BG11817" /db_xref="UniProtKB/Swiss-Prot:Q45498" /translation="MTQMRFTEEDFNTFTIEGLDARMEVLKETVRPKLTALGEHFAPT LSALTGDEMFPHVAKHARRSVNPPADSWVAFANSKRGYKKLPHFQIGLWESHVFVWFA IIYESPIKEEYGKLLEVNQETITKNIPDSFVWSADHTKPGVHKQSEMDKEQLKTLFER LQTVKKAELLCGIQLQKEEVLNMNNQEFLQRIDDAFKQLAFLYRLTQKVTQA*" /label="yktB CDS" gene complement(1451595..1452233) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /label="yktB gene" downshifts complement(1451620) /Source="Nicolas_upshifts" /id="D826" /incds=0 /nref=184 /ntot=257 /MaxReadThrough="2.62959" /MaxDrop="6.54203" /score="26.7765804" /energy="-14.5" /TU="U1217" /idTUdmin="U1217" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1452254..1452273) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1452278) /Source="Nicolas_upshifts" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1452288..1452292) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1452303..1452309 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1452324..1452342 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1452325 /Source="Nicolas_upshifts" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1452363..1452372 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1452385..1452404 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1452389..1452472 /Source="Nicolas_S_feature" /locus_tag="new_1537029_1537112" /HighExp="Etha, S7, M9-stat, S6, S8, BT, Gly, Salt, B60, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S536" upshifts 1452389 /Source="Nicolas_upshifts" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1452473..1452661 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved general stress protein" /protein_id="NP_389349.1" /db_xref="EnsemblGenomes-Gn:BSU14660" /db_xref="EnsemblGenomes-Tr:CAB13339" /db_xref="SubtiList:BG13337" /db_xref="UniProtKB/Swiss-Prot:O31719" /translation="MRQVVKEGFKEEKNNRVAVWRLEVDYELATLYEAMQKENEEQIE QSKNKLERLRKEWIRLNG*" /label="ykzI CDS" gene 1452473..1452661 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /label="ykzI gene" downshifts complement(1452478) /Source="Nicolas_upshifts" /id="D827" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="1.50398" /MaxDrop="3.97385" /score="26.7765804" /energy="-14.5" /TU="NA" /idTUdmin="U1220" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1452654 /Source="Nicolas_upshifts" /id="D828" /incds=0 /nref=13 /ntot=45 /MaxReadThrough="7.33866" /MaxDrop="6.12123" /score="-8.73613673" /energy="-8.1" /TU="U1218,U1219" /idTUdmin="U1219" /TUdmin="-628" /isTUend="FALSE" /label="downshifts" upshifts complement(1452676) /Source="Nicolas_upshifts" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1452684..1452687) /Source="Nicolas_upshift_promotors" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1452731..1452734 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1452751..1452770 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1452754 /Source="Nicolas_upshifts" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" CDS 1452801..1453598 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /EC_number="3.1.3.-" /EC_number="3.1.3.25" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914086, 16682444, 22333191, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914086, 16682444, 22333191, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inositol monophosphatase / 5' nucleotidase (purine nucleoside monophosphate)" /protein_id="NP_389350.1" /db_xref="EnsemblGenomes-Gn:BSU14670" /db_xref="EnsemblGenomes-Tr:CAB13340" /db_xref="GOA:Q45499" /db_xref="InterPro:IPR000760" /db_xref="InterPro:IPR020550" /db_xref="InterPro:IPR020583" /db_xref="InterPro:IPR033942" /db_xref="SubtiList:BG11818" /db_xref="UniProtKB/Swiss-Prot:Q45499" /translation="MTNWTEIDEIAKKWIREAGARITQSMHESLTIETKSNPNDLVTN IDKETEKFFIDRIQETFPGHRILGEEGQGDKIHSLEGVVWIIDPIDGTMNFVHQQRNF AISIGIFENGEGKIGLIYDVVHDELYHAFSGRGAYMNETKLAPLKETVIEEAILAINA TWVTENRRIDQSVLAPLVKRVRGTRSYGSAALELANVAAGRIDAYITMRLAPWDYAAG CVLLNEVGGTYTTIEGEPFTFLENHSVLAGNPSIHKTIFEEYLHARK*" /label="suhB CDS" gene 1452801..1453598 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /label="suhB gene" CDS 1453624..1454052 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389351.1" /db_xref="EnsemblGenomes-Gn:BSU14680" /db_xref="EnsemblGenomes-Tr:CAB13341" /db_xref="GOA:O31720" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13331" /db_xref="UniProtKB/Swiss-Prot:O31720" /translation="MLEKLAEAHPVWKEEEFGDKDAEDYIISYSMYNGSWLVWEKDGM PVAVSYHLEWSPSNGKPWLGTVLIDPAEEKKGHAKMIIEQISKLLRAKHKAMFAGVPI ERREWILFLSQCGFEQLKTEKDEKGKSFMILVKPLAEAAV*" /label="ykzC CDS" gene 1453624..1454052 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /label="ykzC gene" downshifts 1454009 /Source="Nicolas_upshifts" /id="D829" /incds=0 /nref=80 /ntot=232 /MaxReadThrough="4.50069" /MaxDrop="4.3098" /score="-9.99315734" /energy="-11.8" /TU="U1218,U1221" /idTUdmin="U1218" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" S_feature 1454053..1455006 /Source="Nicolas_S_feature" /locus_tag="new_1538693_1539646" /HighExp="H2O2, dia15, Diami, Paraq, G180, G135, G150, dia5, Heat, LBGexp" /AntisenseName="yktD" /AntisenseCor="-1.5120906229522399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="0.117724" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S537" downshifts complement(1454128) /Source="Nicolas_upshifts" /id="D830" /incds=0 /nref=4 /ntot=85 /MaxReadThrough="0.88821" /MaxDrop="3.44773" /score="19.9363134" /energy="-12.8" /TU="NA" /idTUdmin="U1222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1454130..1455044) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_389352.1" /db_xref="EnsemblGenomes-Gn:BSU14690" /db_xref="EnsemblGenomes-Tr:CAB13342" /db_xref="GOA:Q45500" /db_xref="InterPro:IPR007213" /db_xref="InterPro:IPR011610" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11819" /db_xref="UniProtKB/Swiss-Prot:Q45500" /translation="MRKNESSLTSLISAFARAYHSRYDTPLIFDDFIAKDLINEKEFI DISKNMIQEISFFNKEIAERLQNDPEKILKWVAQIQLSPTPLARASYCEKVLHNELIL GAKQYVILGAGLDTFCFRHPELENSLQVFEVDHPATQQLKKNKLKDANLTIPGHLHFV PMDFTKTFSYDPLLDEGFKNTKTFFSLLGVSYYVTREENASLISNLFSHVPPGSSIVF DYADETLFTAKGTSNRVEHMVKMAAASGEPMKSCFTYQEIEHLLESSGLLIYEHLSPD DINDLFFSNRKDNLSAFETIHYIHAVKK*" /label="yktD CDS" gene complement(1454130..1455044) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /label="yktD gene" promotor_-10 complement(1455110..1455129) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1455118) /Source="Nicolas_upshifts" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1455144..1455151) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1455396..1456961) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /EC_number="3.4.24.28" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2128597, 6090407, 8436952, 15205417, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2128597, 6090407, 8436952, 15205417, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral metalloprotease" /protein_id="NP_389353.1" /db_xref="EnsemblGenomes-Gn:BSU14700" /db_xref="EnsemblGenomes-Tr:CAB13343" /db_xref="GOA:P68736" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10448" /db_xref="UniProtKB/Swiss-Prot:P68736" /translation="MGLGKKLSVAVAASFMSLSISLPGVQAAEGHQLKENQTNFLSKN AIAQSELSAPNDKAVKQFLKKNSNIFKGDPSKRLKLVESTTDALGYKHFRYAPVVNGV PIKDSQVIVHVDKSDNVYAVNGELHNQSAAKTDNSQKVSSEKALALAFKAIGKSPDAV SNGAAKNSNKAELKAIETKDGSYRLAYDVTIRYVEPEPANWEVLVDAETGSILKQQNK VEHAAATGSGTTLKGATVPLNISYEGGKYVLRDLSKPTGTQIITYDLQNRQSRLPGTL VSSTTKTFTSSSQRAAVDAHYNLGKVYDYFYSNFKRNSYDNKGSKIVSSVHYGTQYNN AAWTGDQMIYGDGDGSFFSPLSGSLDVTAHEMTHGVTQETANLIYENQPGALNESFSD VFGYFNDTEDWDIGEDITVSQPALRSLSNPTKYNQPDNYANYRNLPNTDEGDYGGVHT NSGIPNKAAYNTITKLGVSKSQQIYYRALTTYLTPSSTFKDAKAALIQSARDLYGSTD AAKVEAAWNAVGL*" /label="nprE CDS" gene complement(1455396..1456961) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /label="nprE gene" promotor_-10 complement(1456996..1457015) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1457007) /Source="Nicolas_upshifts" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1457029..1457036) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1457196..1457201 /created_by="User" /label="SigA_-35" promotor_-10 1457219..1457224 /created_by="User" /label="SigA_-10" CDS 1457246..1459186 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /comment="most likely wrong START codon; starts at -10 with GTG" /modified_by="User" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" /label="ylaA CDS" gene 1457246..1459186 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /comment="most likely wrong START codon; starts at -10 with GTG" /modified_by="User" /label="ylaA gene" CDS 1459176..1459445 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" /label="ylaB CDS" gene 1459176..1459445 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /label="ylaB gene" promotor_-35 1459411..1459415 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1459429..1459448 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1459442 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1459445..1459966 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" /label="sigP CDS" gene 1459445..1459966 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /label="sigP gene" CDS 1459963..1460256 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" /label="sigQ CDS" gene 1459963..1460256 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /label="sigQ gene" CDS complement(1460296..1460907) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" /label="ylaE CDS" gene complement(1460296..1460907) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /label="ylaE gene" downshifts complement(1460310) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1460939..1460958) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1460948) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1460973..1460976) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1461163) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1461180..1461368) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" /label="ylaF CDS" gene complement(1461180..1461368) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /label="ylaF gene" downshifts complement(1461234) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1461390..1461409) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1461407) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1461422..1461429) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1461435..1461454 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1461442 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="upshifts" CDS 1461481..1463319 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" /label="bipA CDS" gene 1461481..1463319 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /label="bipA gene" CDS 1463376..1463693 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" /label="ylaH CDS" gene 1463376..1463693 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /label="ylaH gene" downshifts 1463667 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(1463742) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1463749..1463958) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" /label="ylaI CDS" gene complement(1463749..1463958) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /label="ylaI gene" misc_feature complement(1463972..1463991) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1463987) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1464041..1464670) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" /label="ylaJ CDS" gene complement(1464041..1464670) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /label="ylaJ gene" downshifts complement(1464072) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1464572..1464590) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1464578) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1464602..1464610) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1464705..1464716) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1464710) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1464722..1464727 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1464731..1464737) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1464743..1464761 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1464743 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="upshifts" S_feature 1464744..1464824 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1464825..1466153 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" /label="ylaK CDS" gene 1464825..1466153 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /label="ylaK gene" S_feature complement(1466009..1466156) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1466052) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 1466154..1466744 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1466157..1466642) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" /label="ylaL CDS" gene complement(1466157..1466642) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /label="ylaL gene" promotor_-10 complement(1466654..1466673) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1466682) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1466688..1466695) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1466745..1467674 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" /label="glsB CDS" gene 1466745..1467674 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /label="glsB gene" misc_feature 1467259..1467278 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1467268 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="upshifts" promotor_-35 1467698..1467701 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1467716..1467735 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1467724 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1467772..1468053 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" /label="ylaN CDS" gene 1467772..1468053 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /label="ylaN gene" downshifts 1468042 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" /label="downshifts" promotor_-35 1468116..1468119 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1468132..1468258 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1468132 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1468137..1468143 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1468259..1469470 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" /label="ftsW CDS" gene 1468259..1469470 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /label="ftsW gene" promotor_-35 1469480..1469484 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1469499..1469518 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1469518 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1469545..1472991 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" /label="pycA CDS" gene 1469545..1472991 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /label="pycA gene" promotor_-10 complement(1472557..1472575) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1472577) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1472591..1472596) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1472971 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts 1473016 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" /label="downshifts" downshifts complement(1473048) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 1473060 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(1473394..1474314) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" /label="ctaA CDS" gene complement(1473394..1474314) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /label="ctaA gene" downshifts complement(1473400) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1474354..1474373) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1474369) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1474387..1474394) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1474449..1474456 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1474470..1474489 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1474471..1474576 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1474471 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" S_feature 1474578..1474668 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1474578 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1474584..1474587 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1474602..1474618 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1474669..1475586 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" /label="ctaB CDS" gene 1474669..1475586 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /label="ctaB gene" downshifts 1475615 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" /label="downshifts" upshifts 1475634 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1475635..1475640 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1475694..1475699 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1475714..1475732 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1475722..1475825 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1475722 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" CDS 1475826..1476896 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" /label="ctaC CDS" gene 1475826..1476896 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /label="ctaC gene" CDS 1476929..1478797 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" /label="ctaD CDS" gene 1476929..1478797 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /label="ctaD gene" CDS 1478797..1479420 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" /label="ctaE CDS" gene 1478797..1479420 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /label="ctaE gene" CDS 1479423..1479755 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" /label="ctaF CDS" gene 1479423..1479755 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /label="ctaF gene" CDS 1479782..1480675 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" /label="ctaG CDS" gene 1479782..1480675 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /label="ctaG gene" downshifts 1480650 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1480707..1481069) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" /label="ylbA CDS" gene complement(1480707..1481069) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /label="ylbA gene" downshifts complement(1480726) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1481062..1481066 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1481075..1481088 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1481093..1481112) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1481097..1481208 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1481097 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1481105) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1481127..1481134) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1481209..1481655 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" /label="ylbB CDS" gene 1481209..1481655 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /label="ylbB gene" promotor_-35 1481241..1481248 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1481260..1481279 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1481265 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1481664..1481671 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1481685..1481704 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1481696 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" CDS 1481739..1482779 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" /label="ylbC CDS" gene 1481739..1482779 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /label="ylbC gene" promotor_-10 complement(1482702..1482720) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1482707) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1482736..1482741) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1482759 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 1482943..1482952 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1482966..1482985 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1482980 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="upshifts" CDS 1483011..1483409 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" /label="ylbD CDS" gene 1483011..1483409 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /label="ylbD gene" downshifts complement(1483015) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS 1483425..1483664 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" /label="ylbE CDS" gene 1483425..1483664 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /label="ylbE gene" downshifts 1483643 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1483731..1483738 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1483749..1483768 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1483754 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1483780..1484229 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" /label="ricF CDS" gene 1483780..1484229 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /label="ricF gene" downshifts 1484215 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" /label="downshifts" CDS 1484284..1484556 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" /label="ylbG CDS" gene 1484284..1484556 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /label="ylbG gene" S_feature complement(1484361..1484584) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1484559..1484679 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" /label="csfG RNA" gene 1484559..1484679 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /label="csfG gene" S_feature complement(1484586..1484709) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1484629) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" /label="downshifts" S_feature 1484680..1484785 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1484710..1484722) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1484717) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1484737..1484743) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1484766..1484770 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1484786..1484805 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1484787..1484878 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1484787 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="upshifts" CDS 1484879..1485433 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" /label="rsmD CDS" gene 1484879..1485433 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /label="rsmD gene" CDS 1485438..1485923 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" /label="coaD CDS" gene 1485438..1485923 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /label="coaD gene" downshifts 1485890 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" /label="downshifts" CDS complement(1485934..1487160) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" /label="spoVV CDS" gene complement(1485934..1487160) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /label="spoVV gene" S_feature 1485935..1487209 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1487161..1487262) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1487184..1487191 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1487203..1487222 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1487211..1487340 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1487211 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1487257..1487275) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1487272) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1487292..1487297) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1487341..1488123 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" /label="ylbK CDS" gene 1487341..1488123 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /label="ylbK gene" promotor_-35 1487903..1487909 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1487923..1487934 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1487934 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1488125..1489150 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" /label="ylbL CDS" gene 1488125..1489150 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /label="ylbL gene" downshifts 1489034 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1489167..1490414) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" /label="ylbM CDS" gene complement(1489167..1490414) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /label="ylbM gene" downshifts complement(1489194) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" /label="downshifts" promotor_-35 1490331..1490337 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1490351..1490362 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1490355 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="upshifts" CDS complement(1490411..1490596) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" /label="ylzH CDS" gene complement(1490411..1490596) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /label="ylzH gene" promotor_-35 1490429..1490433 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1490449..1490468 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1490458..1490593 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1490458 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="upshifts" promotor_-10 complement(1490487..1490506) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1490497) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1490520..1490527) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1490564..1490571 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1490585..1490604 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1490595 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1490624..1491142 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" /label="ylbN CDS" gene 1490624..1491142 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /label="ylbN gene" CDS 1491164..1491343 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" /label="rpmF CDS" gene 1491164..1491343 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /label="rpmF gene" downshifts 1491323 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1491366) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1491370..1491373) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1491424..1491429 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1491445..1491463 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1491446 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1491489..1492070 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" /label="gerR CDS" gene 1491489..1492070 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /label="gerR gene" downshifts 1492071 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1492127..1492609) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" /label="ylbP CDS" gene complement(1492127..1492609) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /label="ylbP gene" downshifts complement(1492146) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" /label="downshifts" downshifts 1492599 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1492632..1492651) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1492651) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1492665..1492672) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1492709..1492715 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1492727..1492746 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1492729 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="upshifts" CDS 1492769..1493665 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" /label="panE CDS" gene 1492769..1493665 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /label="panE gene" CDS 1493736..1495355 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" /label="bshC CDS" gene 1493736..1495355 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /label="bshC gene" downshifts 1495327 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 1495389..1495392 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1495407..1495480 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1495407..1495426 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1495407 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1495464) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" /label="downshifts" CDS 1495481..1495912 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" /label="mraZ CDS" gene 1495481..1495912 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /label="mraZ gene" CDS 1495982..1496917 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" /label="rsmH CDS" gene 1495982..1496917 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /label="rsmH gene" S_feature complement(1496584..1498036) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1496957..1497310 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" /label="ftsL CDS" gene 1496957..1497310 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /label="ftsL gene" CDS 1497307..1499457 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" /label="pbpB CDS" gene 1497307..1499457 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /label="pbpB gene" promotor_-10 complement(1498017..1498035) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1498036) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1498050..1498056) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1499440 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1499512..1499517 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1499533..1499551 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1499533 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="upshifts" CDS 1499574..1501514 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" /label="spoVD CDS" gene 1499574..1501514 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /label="spoVD gene" promotor_-35 1501310..1501316 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1501331..1501339 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1501337 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="upshifts" downshifts 1501487 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" /label="downshifts" S_feature 1501532..1501599 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1501569..1501573 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1501589..1501608 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1501601..1501689 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1501601 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" CDS 1501690..1503174 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" /label="murE CDS" gene 1501690..1503174 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /label="murE gene" S_feature 1503175..1503285 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1503286..1504260 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" /label="mraY CDS" gene 1503286..1504260 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /label="mraY gene" CDS 1504261..1505616 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" /label="murD CDS" gene 1504261..1505616 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /label="murD gene" promotor_-35 1505440..1505445 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1505461..1505479 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1505471 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="upshifts" CDS 1505677..1506777 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" /label="spoVE CDS" gene 1505677..1506777 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /label="spoVE gene" S_feature 1506778..1506899 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1506900..1507991 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" /label="murG CDS" gene 1506900..1507991 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /label="murG gene" promotor_-35 1507380..1507389 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1507402..1507417 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1507407 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" promotor_no_box 1507413..1507513 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1507473 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1508023..1508934 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" /label="murB CDS" gene 1508023..1508934 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /label="murB gene" downshifts 1508952 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" /label="downshifts" CDS 1509064..1509855 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" /label="divIB CDS" gene 1509064..1509855 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /label="divIB gene" CDS 1509852..1510547 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" /label="ylxW CDS" gene 1509852..1510547 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /label="ylxW gene" CDS 1510570..1511277 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" /label="ylxX CDS" gene 1510570..1511277 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /label="ylxX gene" CDS 1511295..1511660 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" /label="sbp CDS" gene 1511295..1511660 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /label="sbp gene" promotor_-35 1511512..1511515 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1511531..1511550 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1511547 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" S_feature 1511661..1511833 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1511834..1513156 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" /label="ftsA CDS" gene 1511834..1513156 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /label="ftsA gene" upshifts complement(1512041) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1512045..1512049) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1512064..1512068) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1513192..1514340 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" /label="ftsZ CDS" gene 1513192..1514340 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /label="ftsZ gene" downshifts 1514314 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 1514539..1514642 /Source="Nicolas_S_feature" /locus_tag="new_1599179_1599282" /HighExp="T5.0H, BC, T4.0H, T3.30H, T3.0H, S2, BT, M9-stat, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.953" /TUlongSig="SigA, SigWXY, SigA, Sig-" /TUlongPSig="0.989, 1, 1, 0.436" /label="S561" upshifts 1514539 /Source="Nicolas_upshifts" /id="U1273" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.953046953046953" /xcortree=486 /SigmaFactorBS="tttttatcattttcatatatatggaaattgaatgacatgaaa cgacaatatctgtaattcagATTGTCTACAGTTAATATACagcgatgttctgacaaac c" /listShort="S561, bpr" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1514541..1514560 /Source="Nicolas_upshift_promotors" /id="U1273" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.953046953046953" /xcortree=486 /SigmaFactorBS="tttttatcattttcatatatatggaaattgaatgacatgaaa cgacaatatctgtaattcagATTGTCTACAGTTAATATACagcgatgttctgacaaac c" /listShort="S561, bpr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1514643..1518944 /gene="bpr" /locus_tag="BSU_15300" /old_locus_tag="BSU15300" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1368833, 1938892, 2106512, 2108961, 15205417, 15375126, 18194340, 18414485, 26497454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1368833, 1938892, 2106512, 2108961, 15205417, 15375126, 18194340, 18414485, 26497454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillopeptidase F" /protein_id="NP_389413.1" /db_xref="EnsemblGenomes-Gn:BSU15300" /db_xref="EnsemblGenomes-Tr:CAB13403" /db_xref="GOA:P16397" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR008757" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR012103" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR033857" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10233" /db_xref="UniProtKB/Swiss-Prot:P16397" /translation="MRKKTKNRLISSVLSTVVISSLLFPGAAGASSKVTSPSVKKELQ SAESIQNKISSSLKKSFKKKEKTTFLIKFKDLANPEKAAKAAVKKAKSKKLSAAKTEY QKRSAVVSSLKVTADESQQDVLKYLNTQKDKGNADQIHSYYVVNGIAVHASKEVMEKV VQFPEVEKVLPNEKRQLFKSSSPFNMKKAQKAIKATDGVEWNVDQIDAPKAWALGYDG TGTVVASIDTGVEWNHPALKEKYRGYNPENPNEPENEMNWYDAVAGEASPYDDLAHGT HVTGTMVGSEPDGTNQIGVAPGAKWIAVKAFSEDGGTDADILEAGEWVLAPKDAEGNP HPEMAPDVVNNSWGGGSGLDEWYRDMVNAWRAADIFPEFSAGNTDLFIPGGPGSIANP ANYPESFATGATDINKKLADFSLQGPSPYDEIKPEISAPGVNIRSSVPGQTYEDGWDG TSMAGPHVSAVAALLKQANASLSVDEMEDILTSTAEPLTDSTFPDSPNNGYGHGLVNA FDAVSAVTDGLGKAEGQVSVEGDDQEPPVYQHEKVTEAYEGGSLPLTLTAEDNVSVTS VKLSYKLDQGEWTEITAKRISGDHLKGTYQAEIPDIKGTKLSYKWMIHDFGGHVVSSD VYDVTVKPSITAGYKQDFETAPGGWVASGTNNNWEWGVPSTGPNTAASGEKVYGTNLT GNYANSANMNLVMPPIKAPDSGSLFLQFKSWHNLEDDFDYGYVFVLPEGEKNWEQAGV YNGKTSSWTDEEIDLSAYKGQNIQVMFNLQSDESIAKEGWYIDDVVLSDKSAGKTVKK NKLGVEKPSGKQKKKPVNPKKAKPSANTAVKHQNKAIQPQVLPLKAQVSVVETGKSTY SDQSTGQYTLKHKAGDYTLMAEAYGYQSKTQKVSLKTDQTTQANFTLEEMKKGTLKGT VINKTTGEPVTGASVYVVEDAAVEPAMTNDKGEYMLEAYEGAYTIKVAAPGYYSDEFS VELKGDVTKETALKPFVGYPGEIAYDDGTAENANSYFAAGNGWAVKMTLADGKDKGML TGGLFRFWDTEFPDPGGTEFKVEVYDATGKDGAPGKKIAGPFNAEALRNGEWTKVDLS SKGIMVDKDFYLVYIQSKPDPYSPGLAMDETGQNSGRNWQYIDGKWQPGDKADGNYMI RALVDYEAAVPEITSPTDKSYTNKDSVTVKGNASPGTTVHIYNGEKEAGETKAAADGT FHAGIILNKGENELTATASTDNGTTDASSPITVTLDQEKPELTLDNPKDGGKTNKETL TVKGAVSDDNLKDVKVNGKKATVADGSYSARILLENGRNEIKVIATDLAGNKTTKKTV IDVNFDKPVISGLIPGEDKNLKAGESVKIAFSSAEDLDATFTIRMPLTNARASVQNAT ELPLREISPGRYEGYWTATSSIKAKGAKVEVIVRDDYGNETRKTANGKLNMNTEN*" /label="bpr CDS" gene 1514643..1518944 /gene="bpr" /locus_tag="BSU_15300" /old_locus_tag="BSU15300" /label="bpr gene" downshifts 1518941 /Source="Nicolas_upshifts" /id="D865" /incds=0 /nref=73 /ntot=169 /MaxReadThrough="0.90839" /MaxDrop="8.78054" /score="38.0577497" /energy="-11.4" /TU="NA" /idTUdmin="U1273" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(1518952..1520094) /Source="Nicolas_S_feature" /locus_tag="new_1603592_1604734_c" /HighExp="S8, S6, S7, S5, LoTm, S4, B36, T5.0H, BT, B60" /AntisenseName="spoIIGA" /AntisenseCor="0.71080549463714104" /AntisenseRegPval="-42" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.579" /TUlongSig="NA" /TUlongPSig="NA" /label="S562" downshifts complement(1518994) /Source="Nicolas_upshifts" /id="D866" /incds=0 /nref=5 /ntot=22 /MaxReadThrough="2.36451" /MaxDrop="3.61596" /score="22.1321546" /energy="-9.6" /TU="NA" /idTUdmin="U1275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1519072..1519138 /Source="Nicolas_S_feature" /locus_tag="new_1603712_1603778" /HighExp="M9-stat, T5.0H, S4, LoTm, T3.30H, T3.0H, B60, S3, S5, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S563" upshifts 1519074 /Source="Nicolas_upshifts" /id="U1274" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.282717282717283" /psig="0.534465534465534" /xcortree=966 /SigmaFactorBS="gcagatttccctgaaaaattgtattttcctctcaacattaat tgacagactttcccacagaGCTTGCTTTATACTTATGAAgcaagaaggggaacagcgt g" /listShort="S563, spoIIGA, sigE, S564, sigG, S565" /listLong="ylmA, NA, thiQ" /label="upshifts" misc_feature 1519075..1519094 /Source="Nicolas_upshift_promotors" /id="U1274" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.282717282717283" /psig="0.534465534465534" /xcortree=966 /SigmaFactorBS="gcagatttccctgaaaaattgtattttcctctcaacattaat tgacagactttcccacagaGCTTGCTTTATACTTATGAAgcaagaaggggaacagcgt g" /listShort="S563, spoIIGA, sigE, S564, sigG, S565" /listLong="ylmA, NA, thiQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature complement(1519092..1519104) /Source="Nicolas_upshift_promotors" /id="U1275" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.185814185814186" /xcortree=1053 /SigmaFactorBS="caaatgacatctaaatagattttcacatctgactcctttctt tcttgcctcacgctgttcCCCTTCTTGCTTCataagtataaagcaagctctgtgggaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1519104) /Source="Nicolas_upshifts" /id="U1275" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.185814185814186" /xcortree=1053 /SigmaFactorBS="caaatgacatctaaatagattttcacatctgactcctttctt tcttgcctcacgctgttcCCCTTCTTGCTTCataagtataaagcaagctctgtgggaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1519139..1520068 /gene="spoIIGA" /locus_tag="BSU_15310" /old_locus_tag="BSU15310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7585939, 7729420, 9573195, 9663680, 10498732, 15849754, 16850406, 18378688, 21362630, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7585939, 7729420, 9573195, 9663680, 10498732, 15849754, 16850406, 18378688, 21362630, 22111992; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease processing pro-sigma-E" /protein_id="NP_389414.1" /db_xref="EnsemblGenomes-Gn:BSU15310" /db_xref="EnsemblGenomes-Tr:CAB13405" /db_xref="GOA:P13801" /db_xref="InterPro:IPR005081" /db_xref="SubtiList:BG10234" /db_xref="UniProtKB/Swiss-Prot:P13801" /translation="MKIYLDVIWLLNFCFDALLLLLTAFILKRHVKKRRLVGGAFIGS SIVLLMFTPFSPIVEHPAGKLAFSVVIVVVTFGFKRFRFFFQNLFSFYFATFLMGGGI IGAHSLLQSNSIVQNGVMITNQTGFGDPISWLFIVGGFPALWFFSKRRIEDIETKNIQ YEERVSVQADLGSQTLHVRGLIDSGNQLYDPLTKTPVMIIYIDKLEPIFGTAETMIIR NTDPLEAIEQLDDSFRFLDKMRLIPYRGVGQQNQFLLCVKPDHVTIMTKEEMISADKC LIGISTTKLSADGEFDAIIHPKMLSGKAVKHVS*" /label="spoIIGA CDS" gene 1519139..1520068 /gene="spoIIGA" /locus_tag="BSU_15310" /old_locus_tag="BSU15310" /label="spoIIGA gene" promotor_-10 complement(1520083..1520102) /Source="Nicolas_upshift_promotors" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1520096) /Source="Nicolas_upshifts" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1520117..1520120) /Source="Nicolas_upshift_promotors" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1520131..1520850 /gene="sigE" /locus_tag="BSU_15320" /old_locus_tag="BSU15320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1581961, 7708009, 8464402, 15187183, 20802044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1581961, 7708009, 8464402, 15187183, 20802044; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-29 factor (sigma-E)" /protein_id="NP_389415.2" /db_xref="EnsemblGenomes-Gn:BSU15320" /db_xref="EnsemblGenomes-Tr:CAB13406" /db_xref="GOA:P06222" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014200" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG10235" /db_xref="UniProtKB/Swiss-Prot:P06222" /translation="MKKLKLRLTHLWYKLLMKLGLKSDEVYYIGGSEALPPPLSKDEE QVLLMKLPNGDQAARAILIERNLRLVVYIARKFENTGINIEDLISIGTIGLIKAVNTF NPEKKIKLATYASRCIENEILMYLRRNNKIRSEVSFDEPLNIDWDGNELLLSDVLGTD DDIITKDIEANVDKKLLKKALEQLNEREKQIMELRFGLVGEEEKTQKDVADMMGISQS YISRLEKRIIKRLRKEFNKMV*" /label="sigE CDS" gene 1520131..1520850 /gene="sigE" /locus_tag="BSU_15320" /old_locus_tag="BSU15320" /label="sigE gene" S_feature 1520851..1520940 /Source="Nicolas_S_feature" /locus_tag="new_1605491_1605580" /HighExp="T5.0H, S3, M9-stat, T4.0H, S4, LoTm, S2, B60, B36, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S564" promotor_-35 1520924..1520930 /Source="Nicolas_upshift_promotors" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1520942 /Source="Nicolas_upshifts" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1520944..1520955 /Source="Nicolas_upshift_promotors" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1520990..1521772 /gene="sigG" /locus_tag="BSU_15330" /old_locus_tag="BSU15330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15187183, 15256570, 16166546, 16497325, 17015665, 21935351" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187183, 15256570, 16166546, 16497325, 17015665, 21935351; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-G)" /protein_id="NP_389416.1" /db_xref="EnsemblGenomes-Gn:BSU15330" /db_xref="EnsemblGenomes-Tr:CAB13407" /db_xref="GOA:P19940" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014212" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10236" /db_xref="UniProtKB/Swiss-Prot:P19940" /translation="MSRNKVEICGVDTSKLPVLKNEEMRKLFRQLQDEGDDSAREKLV NGNLRLVLSVIQRFNNRGEYVDDLFQVGCIGLMKSIDNFDLSHNVKFSTYAVPMIIGE IRRYLRDNNPIRVSRSLRDIAYKALQVRERLISETSKEPTAEDIAKVLEVPHEEIVFA LDAIQDPVSLFEPIYNDGGDPIYVMDQISDERNTDSQWIEELALKEGMRRLNDREKMI LRKRFFQGKTQMEVAEEIGISQAQVSRLEKAAIKQMNKNIHQ*" /label="sigG CDS" gene 1520990..1521772 /gene="sigG" /locus_tag="BSU_15330" /old_locus_tag="BSU15330" /label="sigG gene" S_feature 1521773..1521861 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1521826..1521833 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1521846..1521865 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1521863 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1521920..1522714 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" /label="ylmA CDS" gene 1521920..1522714 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /label="ylmA gene" promotor_-35 1522632..1522635 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1522650..1522669 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1522658 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="upshifts" misc_RNA 1522727..1522828 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswE RNA" gene 1522727..1522828 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /label="tswE gene" downshifts 1522815 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" /label="downshifts" CDS 1522916..1524196 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" /label="thiQ CDS" gene 1522916..1524196 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /label="thiQ gene" misc_feature complement(1524137..1524153) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1524142) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1524217..1524222 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1524238..1524256 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1524242 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="upshifts" CDS 1524279..1524524 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" /label="ylmC CDS" gene 1524279..1524524 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /label="ylmC gene" promotor_-35 1524440..1524448 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1524459..1524477 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1524467 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1524525..1524635 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1524627..1524646 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1524637 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1524687..1525523 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" /label="ylmD CDS" gene 1524687..1525523 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /label="ylmD gene" CDS 1525530..1526222 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" /label="ylmE CDS" gene 1525530..1526222 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /label="ylmE gene" CDS 1526219..1526674 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" /label="sepF CDS" gene 1526219..1526674 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /label="sepF gene" CDS 1526681..1526953 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" /label="ylmG CDS" gene 1526681..1526953 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /label="ylmG gene" downshifts 1526942 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" CDS 1527014..1527787 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" /label="ylmH CDS" gene 1527014..1527787 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /label="ylmH gene" promotor_-35 1527503..1527510 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1527524..1527542 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1527547 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1527788..1527880 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1527881..1528375 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" /label="divIVA CDS" gene 1527881..1528375 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /label="divIVA gene" promotor_-35 1528388..1528395 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1528409..1528428 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1528416 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1528438..1528664 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /label="iswA RNA" gene 1528438..1528664 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /label="iswA gene" downshifts 1528631 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" /label="downshifts" CDS 1528717..1531482 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" /label="ileS CDS" gene 1528717..1531482 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /label="ileS gene" downshifts 1531473 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(1531528) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" /label="downshifts" promotor_-35 1531563..1531569 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1531584..1531595 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1531584 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="upshifts" CDS 1531627..1532001 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" /label="ylyA CDS" gene 1531627..1532001 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /label="ylyA gene" promotor_-35 1532033..1532037 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1532052 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" promotor_-10 1532053..1532072 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1532104..1532568 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" /label="lspA CDS" gene 1532104..1532568 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /label="lspA gene" CDS 1532570..1533481 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" /label="rluD CDS" gene 1532570..1533481 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /label="rluD gene" promotor_-35 1533476..1533483 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1533498..1533517 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1533512 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" misc_RNA 1533521..1533637 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaA RNA" gene 1533521..1533637 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /label="pyaA gene" CDS 1533664..1534209 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" /label="pyrR CDS" gene 1533664..1534209 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /label="pyrR gene" downshifts complement(1533858) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" /label="downshifts" downshifts 1534200 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" /label="downshifts" misc_RNA 1534213..1534330 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaB RNA" gene 1534213..1534330 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /label="pyaB gene" CDS 1534383..1535690 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" /label="pyrP CDS" gene 1534383..1535690 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /label="pyrP gene" misc_RNA 1535691..1535805 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaC RNA" gene 1535691..1535805 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /label="pyaC gene" CDS 1535836..1536750 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" /label="pyrB CDS" gene 1535836..1536750 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /label="pyrB gene" CDS 1536734..1538020 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" /label="pyrC CDS" gene 1536734..1538020 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /label="pyrC gene" CDS 1538017..1539111 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" /label="pyrAA CDS" gene 1538017..1539111 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /label="pyrAA gene" CDS 1539096..1542311 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" /label="pyrAB CDS" gene 1539096..1542311 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /label="pyrAB gene" CDS 1542308..1543078 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" /label="pyrK CDS" gene 1542308..1543078 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /label="pyrK gene" CDS 1543078..1544013 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" /label="pyrD CDS" gene 1543078..1544013 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /label="pyrD gene" CDS 1543982..1544701 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" /label="pyrF CDS" gene 1543982..1544701 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /label="pyrF gene" CDS 1544680..1545330 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" /label="pyrE CDS" gene 1544680..1545330 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /label="pyrE gene" downshifts 1545332 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" S_feature 1545377..1545449 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1545429..1545436 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1545450..1545469 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1545451 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1545475..1545580 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /label="mswE RNA" gene 1545475..1545580 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /label="mswE gene" S_feature 1545581..1545741 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1545742..1546443 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" /label="cysH CDS" gene 1545742..1546443 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /label="cysH gene" CDS 1546455..1547519 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" /label="cysP CDS" gene 1546455..1547519 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /label="cysP gene" CDS 1547568..1548716 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" /label="sat CDS" gene 1547568..1548716 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /label="sat gene" upshifts complement(1547657) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1547669..1547673) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1547691..1547692) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1548729..1549322 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" /label="cysC CDS" gene 1548729..1549322 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /label="cysC gene" S_feature 1549323..1549420 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1549421..1550194 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" /label="sumT CDS" gene 1549421..1550194 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /label="sumT gene" promotor_-35 1550099..1550106 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1550121..1550140 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1550122 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" CDS 1550197..1550982 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" /label="sirB CDS" gene 1550197..1550982 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /label="sirB gene" CDS 1550963..1551451 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" /label="sirC CDS" gene 1550963..1551451 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /label="sirC gene" downshifts 1551431 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1551478) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1551491..1553209) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" /label="fbnA CDS" gene complement(1551491..1553209) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /label="fbnA gene" promotor_-10 complement(1553231..1553250) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1553245..1553250 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1553245) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1553263..1553268) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1553266..1553284 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1553270 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="upshifts" CDS 1553325..1555997 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" /label="tcaB CDS" gene 1553325..1555997 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /label="tcaB gene" promotor_-10 complement(1554730..1554749) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1554741) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1554764..1554771) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1556003..1556022 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1556006..1556079 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1556006 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1556080..1556955 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" /label="yloC CDS" gene 1556080..1556955 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /label="yloC gene" CDS 1557032..1557301 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" /label="remA CDS" gene 1557032..1557301 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /label="remA gene" misc_feature complement(1557112..1557116) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1557117) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1557309..1557923 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" /label="gmk CDS" gene 1557309..1557923 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /label="gmk gene" CDS 1557927..1558130 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" /label="rpoZ CDS" gene 1557927..1558130 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /label="rpoZ gene" downshifts 1558119 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS 1558211..1559431 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" /label="coaBC CDS" gene 1558211..1559431 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /label="coaBC gene" S_feature complement(1559270..1559845) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1559428..1561845 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" /label="priA CDS" gene 1559428..1561845 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /label="priA gene" promotor_-10 complement(1559841..1559859) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1559845) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1559873..1559879) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1561696..1561700 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1561716..1561735 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1561727 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1561872..1562354 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" /label="defA CDS" gene 1561872..1562354 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /label="defA gene" CDS 1562359..1563312 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" /label="fmt CDS" gene 1562359..1563312 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /label="fmt gene" CDS 1563299..1564642 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" /label="rsmB CDS" gene 1563299..1564642 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /label="rsmB gene" CDS 1564646..1565737 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" /label="rlmN CDS" gene 1564646..1565737 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /label="rlmN gene" CDS 1565744..1566508 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" /label="prpC CDS" gene 1565744..1566508 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /label="prpC gene" downshifts 1565797 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" /label="downshifts" CDS 1566502..1568448 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" /label="prkC CDS" gene 1566502..1568448 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /label="prkC gene" promotor_-35 1568357..1568363 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1568377..1568395 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1568393 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1568463..1569359 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" /label="rsgA CDS" gene 1568463..1569359 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /label="rsgA gene" CDS 1569364..1570017 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " /label="rpe CDS" gene 1569364..1570017 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /label="rpe gene" promotor_-35 1570015..1570024 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1570038..1570057 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1570043 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="upshifts" CDS 1570090..1570734 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" /label="thiN CDS" gene 1570090..1570734 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /label="thiN gene" promotor_-35 1570495..1570501 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1570512 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="upshifts" promotor_-10 1570516..1570534 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1570625..1570630 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1570646..1570664 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1570659 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1570735..1570805 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1570806..1570886 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" /label="spoVM CDS" gene 1570806..1570886 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /label="spoVM gene" downshifts 1570901 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1570946..1571318 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1570959..1571147) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" /label="rpmB CDS" gene complement(1570959..1571147) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /label="rpmB gene" downshifts complement(1570975) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" downshifts complement(1571021) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1571148..1571240) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1571222..1571241) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1571240) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1571257..1571260) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1571291..1571298 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1571313..1571331 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1571320 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" promotor_-35 1571359..1571362 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1571377..1571396 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1571385 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" CDS 1571424..1571786 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" /label="yloU CDS" gene 1571424..1571786 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /label="yloU gene" downshifts complement(1571637) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1571802..1573463 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" /label="yloV CDS" gene 1571802..1573463 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /label="yloV gene" S_feature 1573464..1573553 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1573526..1573533 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1573547..1573566 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1573555 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="upshifts" CDS 1573602..1574264 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" /label="sdaAB CDS" gene 1573602..1574264 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /label="sdaAB gene" CDS 1574290..1575192 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" /label="sdaAA CDS" gene 1574290..1575192 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /label="sdaAA gene" CDS 1575170..1577218 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" /label="recG CDS" gene 1575170..1577218 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /label="recG gene" promotor_-35 1577254..1577261 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1577276..1577295 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1577282 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1577327..1577893 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" /label="fapR CDS" gene 1577327..1577893 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /label="fapR gene" CDS 1577907..1578908 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " /label="plsX CDS" gene 1577907..1578908 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /label="plsX gene" CDS 1578927..1579880 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" /label="fabD CDS" gene 1578927..1579880 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /label="fabD gene" CDS 1579873..1580613 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" /label="fabG CDS" gene 1579873..1580613 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /label="fabG gene" promotor_-35 1580644..1580648 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1580664..1580683 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1580669 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1580697..1580930 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" /label="acpA CDS" gene 1580697..1580930 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /label="acpA gene" downshifts 1580911 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" promotor_no_box 1580939..1581039 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1580999..1581069 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1580999 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1581070..1581819 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" /label="rnc CDS" gene 1581070..1581819 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /label="rnc gene" downshifts 1581791 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1581861..1581867 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1581879..1581898 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1581901 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1581920..1585480 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" /label="smc CDS" gene 1581920..1585480 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /label="smc gene" S_feature complement(1585414..1586484) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1585500..1586489 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" /label="ftsY CDS" gene 1585500..1586489 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /label="ftsY gene" downshifts 1586476 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1586526..1587011) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" /label="ylqB CDS" gene complement(1586526..1587011) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /label="ylqB gene" downshifts complement(1586529) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1587033..1587051) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1587049) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1587065..1587072) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1587114..1587120 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1587135..1587154 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1587137 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1587188..1587520 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" /label="ylxM CDS" gene 1587188..1587520 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /label="ylxM gene" downshifts complement(1587191) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" /label="downshifts" CDS 1587534..1588874 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" /label="ffh CDS" gene 1587534..1588874 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /label="ffh gene" S_feature 1588875..1588979 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1588980..1589252 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" /label="rpsP CDS" gene 1588980..1589252 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /label="rpsP gene" CDS 1589252..1589497 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" /label="ylqC CDS" gene 1589252..1589497 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /label="ylqC gene" downshifts 1589469 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" S_feature 1589514..1589618 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1589619..1590005 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" /label="ylqD CDS" gene 1589619..1590005 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /label="ylqD gene" CDS 1590010..1590534 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" /label="rimM CDS" gene 1590010..1590534 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /label="rimM gene" CDS 1590531..1591262 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" /label="trmD CDS" gene 1590531..1591262 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /label="trmD gene" promotor_-35 1591268..1591275 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1591289..1591308 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1591293 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" misc_RNA 1591341..1591382 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" /label="L19 leader RNA" gene 1591341..1591382 /locus_tag="BSU_misc_RNA_30" /label="gene" CDS 1591402..1591749 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" /label="rplS CDS" gene 1591402..1591749 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /label="rplS gene" downshifts 1591751 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" /label="downshifts" promotor_-35 1591804..1591810 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1591823..1591891 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1591823 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1591824..1591843 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1591892..1592740 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" /label="rbgA CDS" gene 1591892..1592740 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /label="rbgA gene" promotor_-35 1592761..1592768 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1592781..1592799 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1592791 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1592811..1593578 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" /label="rnhB CDS" gene 1592811..1593578 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /label="rnhB gene" CDS 1593610..1595340 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" /label="ylqG CDS" gene 1593610..1595340 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /label="ylqG gene" upshifts complement(1594847) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1594848..1594867) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1594882..1594889) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1595337..1595618 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" /label="ylqH CDS" gene 1595337..1595618 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /label="ylqH gene" downshifts 1595450 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" /label="downshifts" S_feature 1595619..1595738 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1595710..1595717 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1595731..1595750 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1595740 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1595791..1596948 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" /label="sucC CDS" gene 1595791..1596948 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /label="sucC gene" promotor_no_box complement(1595863..1595963) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1595903) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1596977..1597879 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" /label="sucD CDS" gene 1596977..1597879 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /label="sucD gene" downshifts 1597869 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" /label="downshifts" CDS 1597940..1598833 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" /label="dprA CDS" gene 1597940..1598833 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /label="dprA gene" promotor_-35 1598839..1598846 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1598861..1598880 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1598868..1599020 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1598868 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1599021..1601096 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" /label="topA CDS" gene 1599021..1601096 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /label="topA gene" downshifts 1601066 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 1601128..1601133 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1601140 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1601149..1601167 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1601172..1602479 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" /label="trmFO CDS" gene 1601172..1602479 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /label="trmFO gene" promotor_-35 1602485..1602489 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1602506..1602525 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1602516 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1602547..1603461 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" /label="codV CDS" gene 1602547..1603461 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /label="codV gene" promotor_-35 1602586..1602590 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1602603 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="upshifts" promotor_-10 1602606..1602625 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1603474..1604019 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" /label="clpQ CDS" gene 1603474..1604019 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /label="clpQ gene" CDS 1604036..1605439 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" /label="clpY CDS" gene 1604036..1605439 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /label="clpY gene" CDS 1605479..1606258 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" /label="codY CDS" gene 1605479..1606258 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /label="codY gene" downshifts 1606233 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1606277 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1606378..1606385 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1606398..1606416 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1606409..1606562 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1606409 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1606537..1606544 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1606559..1606578 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1606564 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1606638..1607027 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" /label="flgB CDS" gene 1606638..1607027 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /label="flgB gene" CDS 1607027..1607479 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" /label="flgC CDS" gene 1607027..1607479 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /label="flgC gene" CDS 1607490..1607810 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133968, 1551848, 1905667, 2544561, 9161424, 11133968, 15136044; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal body protein" /protein_id="NP_389502.1" /db_xref="EnsemblGenomes-Gn:BSU16200" /db_xref="EnsemblGenomes-Tr:CAB13493" /db_xref="GOA:P24502" /db_xref="InterPro:IPR001624" /db_xref="SubtiList:BG10239" /db_xref="UniProtKB/Swiss-Prot:P24502" /translation="MINAISPFQVQNTQNTQNATNQVNNSQKTDSSNQTSFSELLKNS ISSLNESQVASDNMTNALAAGKDVNLDEVMIAAQKASISLTAATEFRNKAVEAYQEIM RMQM*" /label="fliE CDS" gene 1607490..1607810 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /label="fliE gene" downshifts complement(1607805) /Source="Nicolas_upshifts" /id="D895" /incds=0 /nref=1 /ntot=83 /MaxReadThrough="1.38909" /MaxDrop="2.66249" /score="0.0645368779" /energy="-7.4" /TU="NA" /idTUdmin="U1325" /TUdmin=2684 /isTUend="FALSE" /label="downshifts" CDS 1607856..1609466 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 11133968, 22670715, 24970213, 28089452; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body M-ring protein" /protein_id="NP_389503.1" /db_xref="EnsemblGenomes-Gn:BSU16210" /db_xref="EnsemblGenomes-Tr:CAB13494" /db_xref="GOA:P23447" /db_xref="InterPro:IPR000067" /db_xref="InterPro:IPR006182" /db_xref="InterPro:IPR013556" /db_xref="InterPro:IPR021157" /db_xref="SubtiList:BG10240" /db_xref="UniProtKB/Swiss-Prot:P23447" /translation="MNRTLMQMKNKTSEFWKNRSKLQKILMVSALAAIIIIGIIISVF ASNSKMAPLYKDLSAEEAGQIKEELDAKKVPNELSNGGTVISVPEDQVDSLKVQMAAE GLPKTGSIDYSFFGQNAGFGLTDNEFDMVKVKATQTELSNLINEMDGIKNSKVMINLP KDAVFVGEEQSAASASIVLQIQPGYTLDQSQINGLYHLVSKSVPNLKEDNIVIMDQNS TYYDKSDSDAGSYADSYSSQQGIKSQVEKDIQKHVQSLLGTMMGQDKVVVSVTADIDF TKENRTEDIVEPVDKENMEGIAVSAEKVSETYQGDGAANGGTAGTGEEDVTNYKADGE NTESGNYEKNSNKINYEVNRIHKEIAESPYKVRDLGIQVMVEPPDAKNTASLSTERQD DIQKILSTVVRTSLDKDETQNQNLSDADINNKIVVSVQPFDGKVNLDTNTEESSGIPL WAYIVGGVLIAAIIVLIIMLIRKKRAQEDEFEEYEYEVPQEPINLPDINEEENETAES VRRKQLEKMAKDKPEDFAKLLRSWLAED*" /label="fliF CDS" gene 1607856..1609466 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /label="fliF gene" CDS 1609479..1610495 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /function="16.5: Explore" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 10440379, 11133968, 28089452; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389504.1" /db_xref="EnsemblGenomes-Gn:BSU16220" /db_xref="EnsemblGenomes-Tr:CAB13495" /db_xref="GOA:P23448" /db_xref="InterPro:IPR000090" /db_xref="InterPro:IPR011002" /db_xref="InterPro:IPR023087" /db_xref="InterPro:IPR028263" /db_xref="InterPro:IPR032779" /db_xref="SubtiList:BG10241" /db_xref="UniProtKB/Swiss-Prot:P23448" /translation="MARRDQDKLTGKQKAAILMISLGLDVSASVYKHLTDEEIERLTL EISGVRSVDHQKKDEIIEEFHNIAIAQDYISQGGLSYARQVLEKALGEDKAENILNRL TSSLQVKPFDFARKAEPEQILNFIQQEHPQTMALILSYLDPVQAGQILSELNPEVQAE VARRIAVMDRTSPEIINEVERILEQKLSSAFTQDYTQTGGIEAVVEVLNGVDRGTEKT ILDSLEIQDPDLAEEIKKRMFVFEDIVTLDNRAIQRVIRDVENDDLLLSLKVASEEVK EIVFNNMSQRMVETFKEEMEFMGPVRLKDVEEAQSRIVSIVRKLEEAGEIVIARGGGD DIIV*" /label="fliG CDS" gene 1609479..1610495 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /label="fliG gene" S_feature 1610496..1610613 /Source="Nicolas_S_feature" /locus_tag="new_1695136_1695253" /HighExp="Lbstat, C90, M0t90, M40t90, Lbtran, C30, LPhT, GM 90, M40t45, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.998, 1, 0.998" /TUlongSig="SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.994, 1, 0.999, 1, 1, 1" /label="S585" promotor_no_box complement(1610559..1610659) /Source="Nicolas_upshift_promotors" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1610599) /Source="Nicolas_upshifts" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1610614..1611240 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /function="16.6: Maintain" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1828465, 12217691, 16522800, 17002279, 26916245; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar export apparatus subunit of cytoplasmic ATPase" /protein_id="NP_389505.2" /db_xref="EnsemblGenomes-Gn:BSU16230" /db_xref="EnsemblGenomes-Tr:CAB13496" /db_xref="GOA:P23449" /db_xref="InterPro:IPR018035" /db_xref="InterPro:IPR022524" /db_xref="SubtiList:BG10242" /db_xref="UniProtKB/Swiss-Prot:P23449" /translation="MARVKEEADRISEQANSHIENIRRQIEQEKNDWAAEKQKLIEEA KAEGFEQGVALGKAEAMKQYAELIGQANSITEMSRKAVEDKLEDANEEIVELAVALAK KVWQQKSDDKEAFLLLVQQVINEVKEYDDISIYVDPYYYETIFQQKDEIQQLLYKECR LGIYADEKAQKGTCYIETPFGRVDASVDTQLMQLKDKLLTALEAGAAE*" /label="fliH CDS" gene 1610614..1611240 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /label="fliH gene" CDS 1611237..1612553 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /EC_number="3.6.3.14" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787361, 16113269, 16780875, 17002279, 26916245; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="flagellar-specific ATPase subunit of export apparatus" /protein_id="NP_389506.2" /db_xref="EnsemblGenomes-Gn:BSU16240" /db_xref="EnsemblGenomes-Tr:CAB13497" /db_xref="GOA:P23445" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000225" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005714" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR022425" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032463" /db_xref="SubtiList:BG10243" /db_xref="UniProtKB/Swiss-Prot:P23445" /translation="MKTQSLIDCIEMTDSYKRYGKVKRVIGLMIESKGPASSIGDLCL IYAKGQSGKVIKAEVVGFQEENILLMPYLEAASIAPGSIVEATGESLRVKVGTGLIGQ VIDAFGEPLDGKLLPKGLSPVSTEQSPPNPMKRPPIREKMGVGVRSIDSLLTVGKGQR IGIFAGSGVGKSTLMGMIAKQTEADLNVIALVGERGREVREFIEKDLGKEGLKRSIVV VATSDQPALMRLKAAYTATAIAEYFRDKGQNVMFMMDSVTRVAMAQREIGLAAGEPPT TKGYTPSVFAILPRLLERTGANEHGTITAFYTVLVDGDDMNEPIADTVRGILDGHIVL DRALANKGQFPAVNVLKSISRVMSNISTKQHLDAANKFRELLSTYQNSEDLINIGAYK RGSSREIDEAIQFYPQLIQFLKQGTDEPALLEESIAALTSLTGNEE*" /label="fliI CDS" gene 1611237..1612553 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /label="fliI gene" CDS 1612556..1612999 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17088562, 26916245, 26984495, 27647891; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar synthesis rod subunit of export ATPase" /protein_id="NP_389507.1" /db_xref="EnsemblGenomes-Gn:BSU16250" /db_xref="EnsemblGenomes-Tr:CAB13498" /db_xref="GOA:P20487" /db_xref="InterPro:IPR012823" /db_xref="SubtiList:BG10245" /db_xref="UniProtKB/Swiss-Prot:P20487" /translation="MAYQFRFQKLLELKENEKDQSLSEYQQSVSEFENVAEKLYENMS KKELLEQNKEKKLKSGMSVQEMRHYQQFVSNLDNTIYHYQKLVIMKRNQMNQKQEILT EKNIEVKKFEKMREKQFKMFALEDKAAEMKEMDDISIKQFMIQGH*" /label="fliJ CDS" gene 1612556..1612999 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /label="fliJ gene" CDS 1613011..1613625 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17586671, 22307758; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative kinesin-like protein" /protein_id="NP_389508.2" /db_xref="EnsemblGenomes-Gn:BSU16260" /db_xref="EnsemblGenomes-Tr:CAB13499" /db_xref="GOA:P23454" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR011002" /db_xref="SubtiList:BG10246" /db_xref="UniProtKB/Swiss-Prot:P23454" /translation="MSGKKKESGKFRSVLLIIILPLMFLLIAGGIVLWAAGINVLKPI QDAAAKTPVLKELVPETENKKGAASSKDSSNTAALEKTIKDQKSEISILNKDLETSKS EIDRLNQKIRSLEKTAEDQKKSSEDHTEGSADSKASSENDKVISVYKSMDSGKAAKII AQLKEQEALKILNGLSKKQLADILAKMTPEQAATYTEKIAASQE*" /label="ylxF CDS" gene 1613011..1613625 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /label="ylxF gene" CDS 1613638..1615101 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16630628, 16949608, 28557186; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook-length control protein (ruler)" /protein_id="NP_389509.2" /db_xref="EnsemblGenomes-Gn:BSU16270" /db_xref="EnsemblGenomes-Tr:CAB13500" /db_xref="GOA:P23451" /db_xref="InterPro:IPR001635" /db_xref="InterPro:IPR021136" /db_xref="SubtiList:BG10247" /db_xref="UniProtKB/Swiss-Prot:P23451" /translation="MKLLELAGPLLQTTTGSAAKNMKSSQGVFQNWLMSEAGLKELSE QGKGTPNSEDQLLADALKKIGEWLNASPEDQDKQNADLLQTLSKLTGKQLDANALQML QNLLQAVESKMSGGTDQLLTETEKIFSEAKTALSANDSASDINGALKSDKEQSNQENE VSEPAKELIYIQMFISQLVEGNKLTDLGNGNEAHAIYQNGDQFLSALEKKGVSQQLIQ DLKQQIFTKAESSSKLYSMTASELKSFQSLMDQMSMLPQKGTKEWSLAESQLKAFLLS KSSESSQDFGKSVLTPLSQSSSSKNASDVSGSIQPVDSKSGLQMLFSGYRGIGGVQTL DLQQMSSDIPNAETKTVADQVINAWKQMKYTPFGRSTGSFTIRLNPEHLGFVTIKLTN ENGMFQSKIIASSQSAKELLEQHLPQLKQSLPNMAVQIDRFTLPVQSGDQPIYGQLAD EQKQQQEGQRQQRQKKQSNDFGDLLDEVSMVEMEEEE*" /label="fliK CDS" gene 1613638..1615101 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /label="fliK gene" CDS 1615098..1615520 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8157595, 14563871, 24748615; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook capping protein" /protein_id="NP_389510.1" /db_xref="EnsemblGenomes-Gn:BSU16280" /db_xref="EnsemblGenomes-Tr:CAB13501" /db_xref="GOA:P23455" /db_xref="InterPro:IPR005648" /db_xref="SubtiList:BG10248" /db_xref="UniProtKB/Swiss-Prot:P23455" /translation="MTSISSEYKLPEKTNTVSTNNSSLGKDEFLKILMTQVQNQDPLN PIDDKEFISQMATFSSLEQMMNLNTTMTQFVENQDPFTTYVDWMGKEVSWTDGKSATD KTGTVSSVKHFKGNYYLVLDDGTEISPANVMSVGQSSK*" /label="flgD CDS" gene 1615098..1615520 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /label="flgD gene" CDS 1615542..1616336 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15502333, 15510139, 27759043, 28120828, 28429800; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook protein" /protein_id="NP_389511.2" /db_xref="EnsemblGenomes-Gn:BSU16290" /db_xref="EnsemblGenomes-Tr:CAB13502" /db_xref="GOA:P23446" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR012836" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10249" /db_xref="UniProtKB/Swiss-Prot:P23446" /translation="MLRSLYSGISGMKNFQTKLDVIGNNIANVNTVGFKKSRVTFKDM VSQTIAGGSAAGATIGGTNSKQIGLGSSSGTIDTIHSTSATQSTGRTLDLAIDGDGYF RIDTGDGTAYTRAGNFYLDNTGTLVTGDGYHVLNMNGGTIKIPTDAQSFSIGSDGKVS IVDAEGKTQDGGQIGIVTFANSDGLDKIGSNLYRESLNSGTASAANQPGDGGTGALKS GFLEMSNVDLTDEFTEMIVAQRGFQSNSKIITTSDEILQELVNLKR*" /label="flgE CDS" gene 1615542..1616336 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /label="flgE gene" CDS 1616376..1616591 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9168127, 29061663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9168127, 29061663; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar power transducer required for swarming" /protein_id="YP_003097728.1" /db_xref="EnsemblGenomes-Gn:BSU16299" /db_xref="EnsemblGenomes-Tr:CAX52619" /db_xref="InterPro:IPR009384" /db_xref="UniProtKB/Swiss-Prot:C0H412" /translation="MIKVTRLNGQPFTLNALFIEQIECFPDTTITLSNGKKFVVKEDE EAVLEKIAAFYRKIQIFAMDQGIEEPE*" /label="swrD CDS" gene 1616376..1616591 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /label="swrD gene" CDS 1616588..1617010 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /function="16.5: Explore" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10439416, 12787361, 16166542, 23264580, 25714720, 28717192; Product type f : factor" /codon_start=1 /transl_table=11 /product="flagellar basal-body (stator) associated protein" /protein_id="NP_389512.1" /db_xref="EnsemblGenomes-Gn:BSU16300" /db_xref="EnsemblGenomes-Tr:CAB13503" /db_xref="GOA:P23452" /db_xref="InterPro:IPR005503" /db_xref="SubtiList:BG10250" /db_xref="UniProtKB/Swiss-Prot:P23452" /translation="MKKKLMIILLIILIVIGALGAAAYFVLGGKSEKSEAKKSIDEIV ASSVDVEEITTNLKSDNIIRLAIKLETDSDKSKEELEKRDFQVKDAVISLLADTNADQ IEGDKGKETFKKELKDKINSYLQEGKVEKVYITSFNLQ*" /label="fliL CDS" gene 1616588..1617010 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /label="fliL gene" CDS 1617044..1618042 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7787061, 16547037, 16796690, 16882724, 17015643, 17050923, 22720735, 28625846; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389513.1" /db_xref="EnsemblGenomes-Gn:BSU16310" /db_xref="EnsemblGenomes-Tr:CAB13504" /db_xref="GOA:P23453" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR001689" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10251" /db_xref="UniProtKB/Swiss-Prot:P23453" /translation="MSGEVLSQNEIDALLSAISTGEMDAEELKKEEKEKKVKVYDFKR ALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIHISVSSVDQVPYEEFIRSIPNMT ILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHNKVDSLTEIETKIISNLFEN ALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCI PHIVLEPLIPKLSVHYWMQSDRNEPKPEETKSLEKRIMTAQIPVVAELGTSELTIEEF LSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQILDHDIRGEQDGE*" /label="fliM CDS" gene 1617044..1618042 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /label="fliM gene" CDS 1618032..1619168 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing phosphatase" /protein_id="NP_389514.1" /db_xref="EnsemblGenomes-Gn:BSU16320" /db_xref="EnsemblGenomes-Tr:CAB13505" /db_xref="GOA:P24073" /db_xref="InterPro:IPR001172" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR012826" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10252" /db_xref="UniProtKB/Swiss-Prot:P24073" /translation="MENNRLSQDEIDALLNGTGSTLDEPEIPEVDDLSEMERDAIGEI GNISFGSSATALSTLLNQKVDITTPSVTVIPRSKISDAFPEPYVAIEVNYTEGFSGSN LLVVEQSDAAIIADLMIGGDGKGADPSLGEIHLSAVQEAMNQMMGSAATSMSTVFSKK IDISPPRVELLDVTEEKGTDRIPDDEMLVKVSFNLKVGELIDSSIMQLYPLTFAKDLI SSLMNSESAEEEETVQPEVTYEQPKEPVTPEPRIEPKQQQQPPKRQGTAKKAAPVQVS PVEFSAFDPNEAVQAPIHNLDMLLDIPLSITVELGRTKRSVKEILELSAGSIIELDKL AGEPVDILVNQRIVAKGEVVVIEENFGVRVTDILSQAERINNLK*" /label="fliY CDS" gene 1618032..1619168 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /label="fliY gene" CDS 1619194..1619556 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10196193, 12864845, 12920116, 14749334, 23226535, 28542702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10196193, 12864845, 12920116, 14749334, 23226535, 28542702; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of chemotaxis and motility" /protein_id="NP_389515.1" /db_xref="EnsemblGenomes-Gn:BSU16330" /db_xref="EnsemblGenomes-Tr:CAB13506" /db_xref="GOA:P24072" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG10258" /db_xref="UniProtKB/Swiss-Prot:P24072" /translation="MAHRILIVDDAAFMRMMIKDILVKNGFEVVAEAENGAQAVEKYK EHSPDLVTMDITMPEMDGITALKEIKQIDAQARIIMCSAMGQQSMVIDAIQAGAKDFI VKPFQADRVLEAINKTLN*" /label="cheY CDS" gene 1619194..1619556 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /label="cheY gene" CDS 1619571..1620230 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10791024, 1597417, 16513753, 24204316; Product type r: regulator" /codon_start=1 /transl_table=11 /product="flagellar regulatory protein" /protein_id="NP_389516.1" /db_xref="EnsemblGenomes-Gn:BSU16340" /db_xref="EnsemblGenomes-Tr:CAB13507" /db_xref="GOA:P35536" /db_xref="InterPro:IPR022781" /db_xref="SubtiList:BG10259" /db_xref="UniProtKB/Swiss-Prot:P35536" /translation="MKKSQYFIVFICFFVLFSVHPIAAAAADSDNSTVNEWFQKKDEK TADQSEQKKEKTTKTADETEGAAAPSVSAFDFVKMIFALLFVIVLIYGLVKLMNKRNR LLKPFQYVENIGGTSVGQNRSIQLIKVGKSVLVVGVGETIQLLKEIEDEKEIEVILSQ HEEAMSSKIEWQKFVKPLKSSEHQPQQKLPSFSKALKEQLEELKQNRSEGKKKGPRHH E*" /label="fliZ CDS" gene 1619571..1620230 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /label="fliZ gene" CDS 1620223..1620888 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /function="16.3: Control" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15516571, 15849754, 16850406, 22720735, 26244495, 27855178, 28559296; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389517.1" /db_xref="EnsemblGenomes-Gn:BSU16350" /db_xref="EnsemblGenomes-Tr:CAB13508" /db_xref="GOA:P35528" /db_xref="InterPro:IPR005837" /db_xref="InterPro:IPR005838" /db_xref="SubtiList:BG10260" /db_xref="UniProtKB/Swiss-Prot:P35528" /translation="MNEFINIFSSSDPENVSSTVKLLLLLTVFSVAPGILILMTCFTR IVIVLSFVRTSLATQSMPPNQVLIGLALFLTFFIMAPTFSEINKEALTPLMDNKISLD EAYTKAEEPIKEFMSKHTRQKDLALFMNYAKMDKPESLKDIPLTTMVPAFAISELKTA FQIGFMIFIPFLIIDMVVASVLMSMGMMMLPPVMISLPFKILLFVLVDGWYLIVKSLL QSF*" /label="fliP CDS" gene 1620223..1620888 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /label="fliP gene" CDS 1620903..1621172 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 15516571, 27855178; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389518.1" /db_xref="EnsemblGenomes-Gn:BSU16360" /db_xref="EnsemblGenomes-Tr:CAB13509" /db_xref="GOA:P35535" /db_xref="InterPro:IPR002191" /db_xref="InterPro:IPR006305" /db_xref="SubtiList:BG10261" /db_xref="UniProtKB/Swiss-Prot:P35535" /translation="MSSEFVISMAEKAVYVTLMISGPLLAIALLVGLIVSIFQATTQI QEQTLAFIPKIVAVLLALIFFGPWMLSTILSFTTELFSNLNRFAG*" /label="fliQ CDS" gene 1620903..1621172 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /label="fliQ gene" CDS 1621180..1621959 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060055, 15516571, 15849754, 16850406, 28771474; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389519.2" /db_xref="EnsemblGenomes-Gn:BSU16370" /db_xref="EnsemblGenomes-Tr:CAB13510" /db_xref="GOA:P35537" /db_xref="InterPro:IPR002010" /db_xref="InterPro:IPR006303" /db_xref="SubtiList:BG10262" /db_xref="UniProtKB/Swiss-Prot:P35537" /translation="MNSIIDLFPAFLLVFIRISAFFVTIPLFGHRNVPAVHRIGFAFF LAVICFSTIDKPPSLEIDEHYMLLAFKEALVGLCLGLIAYMMIAAVQIAGSFIDFQMG FSIANVIDPQTGAQSPLIGQFIYTMALLFMLSVNAHHLLLDGIYYSFQYISVDQAFPN FGDEKFAYFIAKSFNAMFIIAFQMSAPVVASLFLVDLALGIVARTVPQLNVFVVGLPL KIAVSFIMLIVCMSVIFVVVRNVFSLTIETMRNLLALVGVS*" /label="fliR CDS" gene 1621180..1621959 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /label="fliR gene" CDS 1621959..1623041 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /function="16.1: Circulate" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 16949608, 17050924, 17067800, 28557186, 28771466; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389520.1" /db_xref="EnsemblGenomes-Gn:BSU16380" /db_xref="EnsemblGenomes-Tr:CAB13511" /db_xref="GOA:P35538" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR006136" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG10543" /db_xref="UniProtKB/Swiss-Prot:P35538" /translation="MKLRVDLQFFAGEKTEKATPKKRKDTRKKGQVAKSSDVNTAVSL LVIFLSLIAIGPYMRDRLLSFIETFYTESLTMKLSESNVHTLFVSLLKDMGMILAPIL LVALVAGVVSNYMQVGFLFSAEVIQPKLEKLDPIKGFKRIYSMRAIVELIKSILKIVV VGFAAFAVLWLHYGEILRLPLLTPEEALSFVSKLTLWMGLSGAGALLILAGLDYLYQR FDYEKNIKMSKQDIKDEYKKSEGDPIIKSKIKQRQREMAMRRMMQEVPKADVIITNPT HYAIALKYDEEKMDAPYIVAKGVDHLALKIRKIAKEHDVMMVENRPLARALYDQVEID QAVPEEFFKVLAEILAYVYKTKQKVY*" /label="flhB CDS" gene 1621959..1623041 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /label="flhB gene" CDS 1623074..1625107 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10234819, 15516571, 20534509, 28771466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10234819, 15516571, 20534509, 28771466; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389521.2" /db_xref="EnsemblGenomes-Gn:BSU16390" /db_xref="EnsemblGenomes-Tr:CAB13512" /db_xref="GOA:P35620" /db_xref="InterPro:IPR001712" /db_xref="InterPro:IPR006301" /db_xref="InterPro:IPR025505" /db_xref="PDB:3MIX" /db_xref="SubtiList:BG10542" /db_xref="UniProtKB/Swiss-Prot:P35620" /translation="MSTRDLSVLISVVLIVAMLVIPFPPWLLSILIIINISLALIVLL TTMNMQEALQFSIFPSLLLLLTLFRLGLNVSTTRSILSHGEGGKVVETFGNFVVGGNV LVGLVVFIILIIIQFIVITKGAERVSEVAARFTLDAMPGKQMSIDADLNAGMITEQEA KHRREKVAREADFYGAMDGASKFVKGDAIAGIIIVMINIIFGIVIGMLQQGMSIQEAA SHFTMLTVGDGIVSQIPALLISTATGIVVTRAASEGNLGHDITGQLFAYPKLLYVAAA TIMLLGIFTPIGILLTGPLAGLLAFGAYTLSKSGKEKEEVDEILEEEAEVDELKSPES VVQLLHIDPIEFEFGYGLIPLADANQGGDLLDRIVMIRRQLALELGLVIPVVRIRDNI ALQPNEYRLKIKGNEVAKGELLLDHYLAMSPTPEDDLIEGIETVEPSFGLPAKWISEA VKDEADMLGYTVVDPASVVSTHITEKIKQHAHELIGRQETKQLIDHLKESYPVLVEEV TPNPLSVGDIQKVLAKLLKEKVSIRNLVTIFETLADYGKLTTDSDLLTEYTRQALAKQ ITAQFAKENEVLKVVTCSGRVEKAIADGVQQTEHGNYLSLEPDISESIVRSVAKEAEQ LSLRQETAILLCSPPVRMYVKQLLERYFPDLPVLSYNELEANVEVQSIGVVDI*" /label="flhA CDS" gene 1623074..1625107 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /label="flhA gene" CDS 1625107..1626207 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1447978, 15317803, 16980502, 17565194, 17699634, 26195616, 27807433; Product type t: transporter" /codon_start=1 /transl_table=11 /product="GTPase involved in the export of flagella and number regulation" /protein_id="NP_389522.1" /db_xref="EnsemblGenomes-Gn:BSU16400" /db_xref="EnsemblGenomes-Tr:CAB13513" /db_xref="GOA:Q01960" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR020006" /db_xref="InterPro:IPR027417" /db_xref="PDB:2PX0" /db_xref="PDB:2PX3" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10544" /db_xref="UniProtKB/Swiss-Prot:Q01960" /translation="MKIKKFTAASMQEAALLIRKELGNEAVILNSKKIKKRKWFGLVN KPAVEVIAVLDQDFLEKKTPQKAAEPKQTLKTPVSSPKIEERTYPPQIPAQQELGDFS AYQSVLPEPLRKAEKLLQETGIKESTKTNTLKKLLRFSVEAGGLTEENVVGKLQEILC DMLPSADKWQEPIHSKYIVLFGSTGAGKTTTLAKLAAISMLEKHKKIAFITTDTYRIA AVEQLKTYAELLQAPLEVCYTKEEFQQAKELFSEYDHVFVDTAGRNFKDPQYIDELKE TIPFESSIQSFLVLSATAKYEDMKHIVKRFSSVPVNQYIFTKIDETTSLGSVFNILAE SKIGVGFMTNGQNVPEDIQTVSPLGFVRMLCR*" /label="flhF CDS" gene 1625107..1626207 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /label="flhF gene" promotor_-10 complement(1626084..1626103) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1626091) /Source="Nicolas_upshifts" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1626117..1626126) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1626198..1627094 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /function="16.5: Explore" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15361076, 25733861, 26411371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15361076, 25733861, 26411371; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase affecting flagellar basal body localisation and number" /protein_id="NP_389523.1" /db_xref="EnsemblGenomes-Gn:BSU16410" /db_xref="EnsemblGenomes-Tr:CAB13514" /db_xref="GOA:P40742" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR033875" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10254" /db_xref="UniProtKB/Swiss-Prot:P40742" /translation="MQMNRYDQAATLRAKMEKRERVLPMVYSQKAKTLAVISGKGGVG KSNITLNMALALQDKGKKVLLIDLDIGMGNIDILIGNSSSATIIDVLTDRKPLLQSLS VGPKGLRYISGGTGLDVMFQLDQRKWTFFANELSHALSQFDYVLFDMGAGLSKDQLPF ILSAEDILIITTPEPTAIMDAYSAVKHLVLTENKLSMKVAVNRCRDQKEGLDAFARLS RTIHMFLDVQVQFAGSVSDDVIVSKAVVEQVPFFIKSPQAKASRSVRILADALFEREE TRHKEDKQTFIEKLSSFLMRRA*" /label="flhG CDS" gene 1626198..1627094 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /label="flhG gene" CDS 1627096..1628169 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /EC_number="3.1.1.61" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1738311, 10632876, 12123464, 21515776" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1738311, 10632876, 12123464, 21515776; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCP)-glutamate methylesterase" /protein_id="NP_389524.2" /db_xref="EnsemblGenomes-Gn:BSU16420" /db_xref="EnsemblGenomes-Tr:CAB13515" /db_xref="GOA:Q05522" /db_xref="InterPro:IPR000673" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR008248" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR035909" /db_xref="SubtiList:BG10255" /db_xref="UniProtKB/Swiss-Prot:Q05522" /translation="MIRVLVVDDSAFMRKMISDFLTEEKQIEVIGTARNGEEALKKIE LLKPDVITLDVEMPVMNGTDTLRKIIEIYNLPVIMVSSQTEKGKECTINCLEIGAFDF ITKPSGSISLDLYKIKEQLVERVVAAGLSGKRKRPVSQTVRPEPIVRAVVKPELSKPK PGTGRQIVCIGTSTGGPRALQKVIPKLPKDLNAPVVVVQHMPEGFTASLADRLNHLSD IQVKEAKDGEAALNGCVYIAPGGKNISVIKNSEGLQVVLDNHDTPSRHKPSADYLFRS VGKLTDYEKVAVIMTGMGSDGTAGLKDMLTAGNVKAIAESEESCVVYGMPKAAVKAGL IHEIKHVEDIAASITSCVKKERV*" /label="cheB CDS" gene 1627096..1628169 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /label="cheB gene" CDS 1628175..1630193 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotactic two-component sensor histidine kinase" /protein_id="NP_389525.2" /db_xref="EnsemblGenomes-Gn:BSU16430" /db_xref="EnsemblGenomes-Tr:CAB13516" /db_xref="GOA:P29072" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004105" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008207" /db_xref="InterPro:IPR010808" /db_xref="InterPro:IPR035891" /db_xref="InterPro:IPR036061" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036641" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037006" /db_xref="InterPro:IPR037052" /db_xref="SubtiList:BG10256" /db_xref="UniProtKB/Swiss-Prot:P29072" /translation="MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRA AHTLKGMSATMGYTDLAHLTHLLENVLDAIRNGDMEVTSDWLDILFEALDHLETMVQS IIDGGDGKRDISEVSAKLDVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEE QGFKRYEIKISLNENCMLKAVRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVC FLTHQSAEDIEQLINGVSEIEHVEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQK QPAKNDEQAKHSAGGSKTIRVNIDRLDSLMNLFEELVIDRGRLEQIAKELEHNELTET VERMTRISGDLQSIILNMRMVPVETVFNRFPRMIRQLQKELNKKIELSIIGAETELDR TVIDEIGDPLVHLIRNSIDHGIEAPETRLQKGKPESGKVVLKAYHSGNHVFIEVEDDG AGLNRKKILEKALERGVITEKEAETLEDNQIYELIFAPGFSTADQISDISGRGVGLDV VKNKLESLGGSVSVKSAEGQGSLFSIQLPLTLSIISVLLIKLEEETFAIPISSIIETA VIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKIEDTRKDAEQLHIIVVKKGDKPTAF VVDSFIGQQEVVLKSLGDYLTNVFAISGATILGDGEVALIIDCNALII*" /label="cheA CDS" gene 1628175..1630193 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /label="cheA gene" CDS 1630215..1630685 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12864845, 15451661, 1624415, 8169223, 8169224" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12864845, 15451661, 1624415, 8169223, 8169224; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulation of CheA activity in response to attractants (chemotaxis)" /protein_id="NP_389526.1" /db_xref="EnsemblGenomes-Gn:BSU16440" /db_xref="EnsemblGenomes-Tr:CAB13517" /db_xref="GOA:P39802" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10692" /db_xref="UniProtKB/Swiss-Prot:P39802" /translation="MTAEIKTGEKMIVFMVNGKEYAISVTQVKSIEKWQKPTRVPGVE PYICGVINLRGVVTPVIDLRKRLNLPEYEITDETRIIIIAYRDIEVGWIVDEANDVIT VHESEIESAPEGVQKDTDVSIEQIVKQENRLLNIIDANAVLDKESSQSAVPDQA*" /label="cheW CDS" gene 1630215..1630685 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /label="cheW gene" CDS 1630704..1631333 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal terminating phosphatase of CheR-mediated methylation of methyl-accepting chemotaxis proteins (MCPs)" /protein_id="NP_389527.1" /db_xref="EnsemblGenomes-Gn:BSU16450" /db_xref="EnsemblGenomes-Tr:CAB13518" /db_xref="GOA:P40403" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR028976" /db_xref="SubtiList:BG10749" /db_xref="UniProtKB/Swiss-Prot:P40403" /translation="MSIFNGIKEEQMDILREVGNIGAGHSASAMAQLLNRKIDMEVPF AKLLSFDELVDFFGGADVPVASIFLRMEGDLTGSMFFIMPFFQAEQFIRELIGNPDFD IEDLGEDHMSSSALHELGNILAGSYLTALADLTKLQLYPSVPEVSLDMFGAVISEGLM ELSQVGEHAIVVDTSIFDQSHQQELKAHMFMLPDYDSFEKLFVALGASL*" /label="cheC CDS" gene 1630704..1631333 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /label="cheC gene" CDS 1631330..1631830 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15546616, 16469702, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15546616, 16469702, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sequence specific deamidase required for methylation of methyl-accepting chemotaxis proteins (MCPs) by CheR" /protein_id="NP_389528.1" /db_xref="EnsemblGenomes-Gn:BSU16460" /db_xref="EnsemblGenomes-Tr:CAB13519" /db_xref="GOA:P40404" /db_xref="InterPro:IPR005659" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG10750" /db_xref="UniProtKB/Swiss-Prot:P40404" /translation="MSTTEAVVIKVGIADVKIARFPDTIRTSGLGSCVGLVLYDKEKQ TAGLVHVMLPDSTLSKTAELNRAKYADTAVQTTIDMLIEAGCRKFALKAKLAGGSEMF KFKSTNDLMKIGPRNVLAIKEQLSLFNIPIISEDTGGSSGRTIEFEPKSCMLHIRTVK QGEKTI*" /label="cheD CDS" gene 1631330..1631830 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /label="cheD gene" CDS 1631853..1632617 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" /label="sigD CDS" gene 1631853..1632617 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /label="sigD gene" promotor_-35 1632627..1632633 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1632646..1633149 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" /label="swrB CDS" gene 1632646..1633149 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /label="swrB gene" promotor_-10 1632648..1632659 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1632662 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1633145..1633151 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1633166..1633185 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1633168..1633292 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1633168 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1633293..1634033 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" /label="rpsB CDS" gene 1633293..1634033 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /label="rpsB gene" downshifts 1634015 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" /label="downshifts" S_feature 1634060..1634134 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1634135..1635016 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" /label="tsf CDS" gene 1634135..1635016 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /label="tsf gene" S_feature 1635017..1635161 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1635162..1635884 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" /label="pyrH CDS" gene 1635162..1635884 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /label="pyrH gene" CDS 1635886..1636443 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" /label="frr CDS" gene 1635886..1636443 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /label="frr gene" downshifts complement(1636390) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" /label="downshifts" promotor_-35 1636432..1636435 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1636450..1636469 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1636468..1636573 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1636468 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1636574..1637356 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" /label="uppS CDS" gene 1636574..1637356 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /label="uppS gene" CDS 1637360..1638169 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" /label="cdsA" gene 1637360..1638169 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /label="cdsA gene" promotor_-35 1638150..1638157 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1638172..1638191 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1638173 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1638231..1639382 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" /label="dxr CDS" gene 1638231..1639382 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /label="dxr gene" CDS 1639389..1640657 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" /label="rasP CDS" gene 1639389..1640657 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /label="rasP gene" CDS 1640690..1642384 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" /label="proS CDS" gene 1640690..1642384 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /label="proS gene" S_feature 1642385..1642492 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1642493..1646806 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" /label="polC CDS" gene 1642493..1646806 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /label="polC gene" S_feature 1646807..1646871 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1646817..1647034 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surG RNA" gene 1646817..1647034 /gene="surG" /locus_tag="BSU_misc_RNA_71" /label="surG gene" promotor_-35 1646843..1646849 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1646864..1646875 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1646873..1646940 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1646873 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="upshifts" promotor_-35 1646923..1646929 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1646942..1647135 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1646942 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="upshifts" promotor_-10 1646943..1646962 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1647136..1647606 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" /label="rimP CDS" gene 1647136..1647606 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /label="rimP gene" downshifts complement(1647457) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1647641..1648756 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" /label="nusA CDS" gene 1647641..1648756 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /label="nusA gene" promotor_no_box complement(1647703..1647803) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1647743) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1648770..1649045 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" /label="rulR CDS" gene 1648770..1649045 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /label="rulR gene" CDS 1649047..1649349 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" /label="rulQ CDS" gene 1649047..1649349 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /label="rulQ gene" CDS 1649369..1651519 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" /label="infB CDS" gene 1649369..1651519 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /label="infB gene" promotor_-35 1651414..1651420 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1651429 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1651435..1651453 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1651516..1651794 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" /label="ylxP CDS" gene 1651516..1651794 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo /label="ylxP gene" CDS 1651811..1652164 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" /label="rbfA CDS" gene 1651811..1652164 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /label="rbfA gene" downshifts 1652155 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" CDS 1652246..1653175 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" /label="truB CDS" gene 1652246..1653175 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /label="truB gene" promotor_-35 1652960..1652967 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1652981..1653000 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1652990 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1653194..1654144 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" /label="ribC CDS" gene 1653194..1654144 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /label="ribC gene" promotor_-35 1654177..1654183 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1654184..1654300 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1654184 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1654198..1654217 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1654301..1654570 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" /label="rpsO CDS" gene 1654301..1654570 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /label="rpsO gene" downshifts 1654553 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" S_feature 1654598..1654683 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1654664..1654667 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1654683..1654702 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1654685 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1654743..1656860 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" /label="pnpA CDS" gene 1654743..1656860 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /label="pnpA gene" downshifts 1656643 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 1656844 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature 1656889..1656977 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1656978..1657937 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" /label="ylxY CDS" gene 1656978..1657937 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /label="ylxY gene" promotor_-10 complement(1657046..1657054) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1657049) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1657068..1657075) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1657541..1657546 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1657562..1657580 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1657567 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1657977..1659206 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" /label="mlpA CDS" gene 1657977..1659206 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /label="mlpA gene" downshifts 1659195 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1659235..1659240 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1659250 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1659256..1659274 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1659284..1659541 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" /label="ymxH CDS" gene 1659284..1659541 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /label="ymxH gene" S_feature 1659542..1659596 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1659569 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1659638..1659647 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1659657..1659726 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1659657 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="upshifts" promotor_-10 1659661..1659680 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1659727..1660620 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" /label="spoVFA CDS" gene 1659727..1660620 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /label="spoVFA gene" CDS 1660623..1661225 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" /label="spoVFB CDS" gene 1660623..1661225 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /label="spoVFB gene" misc_feature 1661279..1661298 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1661279..1661350 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1661279 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1661351..1662391 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" /label="asd CDS" gene 1661351..1662391 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /label="asd gene" S_feature 1662392..1662482 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1662483..1663697 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" /label="dapG CDS" gene 1662483..1663697 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /label="dapG gene" CDS 1663728..1664600 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" /label="dapA CDS" gene 1663728..1664600 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /label="dapA gene" S_feature complement(1664071..1665255) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1664607 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1664700..1664703 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1664717 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1664719..1664738 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1664778..1666445 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" /label="rnjB CDS" gene 1664778..1666445 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /label="rnjB gene" promotor_-10 complement(1665242..1665260) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1665259) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1665276..1665281) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1666433 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1666500..1666506 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1666520..1666531 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1666521 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="upshifts" CDS 1666561..1667298 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" /label="tepA CDS" gene 1666561..1667298 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /label="tepA gene" CDS 1667295..1667507 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" /label="tepJ CDS" gene 1667295..1667507 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /label="tepJ gene" misc_feature 1667535..1667554 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1667549 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="upshifts" CDS 1667638..1670001 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" /label="spoIIIE CDS" gene 1667638..1670001 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /label="spoIIIE gene" S_feature 1670002..1670102 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1670063..1670070 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1670085..1670104 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1670103 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="upshifts" CDS 1670145..1670870 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" /label="ymfC CDS" gene 1670145..1670870 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /label="ymfC gene" downshifts 1670857 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 1670926..1670932 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1670945 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1670947..1670958 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1671009..1672217 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" /label="bcbE CDS" gene 1671009..1672217 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /label="bcbE gene" downshifts 1672175 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1672286..1672293 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1672306..1672325 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1672328 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" promotor_-35 1672340..1672343 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1672359..1672371 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1672373 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1672397..1673677 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" /label="ymfF CDS" gene 1672397..1673677 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /label="ymfF gene" CDS 1673674..1674960 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" /label="ymfH CDS" gene 1673674..1674960 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /label="ymfH gene" downshifts 1674810 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" /label="downshifts" S_feature 1674961..1675014 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1675015..1675743 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" /label="efpI CDS" gene 1675015..1675743 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /label="efpI gene" promotor_-35 1675759..1675765 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1675777 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1675779..1675790 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1675790) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1675801..1675815) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1675824..1675828) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1675824..1676081 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" /label="ymfJ CDS" gene 1675824..1676081 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /label="ymfJ gene" downshifts 1676066 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1676098) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" /label="downshifts" promotor_-35 1676139..1676142 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1676157..1676176 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1676157 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1676211..1676726 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" /label="ymfKn CDS" gene 1676211..1676726 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo /label="ymfKn gene" CDS 1676662..1677000 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" /label="ymfKc CDS" gene 1676662..1677000 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo /label="ymfKc gene" CDS 1677067..1677933 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" /label="rodZ CDS" gene 1677067..1677933 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /label="rodZ gene" promotor_no_box 1677130..1677230 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1677190 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" downshifts 1677893 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1677983..1678564 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" /label="pgsA CDS" gene 1677983..1678564 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /label="pgsA gene" CDS 1678582..1679832 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" /label="cinA CDS" gene 1678582..1679832 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /label="cinA gene" S_feature 1679833..1679959 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1679939..1679946 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1679961..1679980 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1679961 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1680005..1681051 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" /label="recA CDS" gene 1680005..1681051 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /label="recA gene" downshifts 1681063 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 1681108..1681173 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1681145..1681154 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1681167..1681182 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1681175 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1681219..1682394 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " /label="pbpX CDS" gene 1681219..1682394 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /label="pbpX gene" S_feature 1682395..1682494 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1682468..1682475 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1682489..1682508 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1682496..1682669 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1682496 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1682670..1684232 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" /label="rny CDS" gene 1682670..1684232 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /label="rny gene" downshifts 1684209 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" CDS 1684301..1685095 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" /label="pdeB CDS" gene 1684301..1685095 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /label="pdeB gene" promotor_-35 1684850..1684855 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1684871..1684889 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1684891 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="upshifts" promotor_-35 1685139..1685144 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1685155..1685294 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1685155 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="upshifts" promotor_-10 1685160..1685178 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1685187) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1685198..1685211) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1685220..1685224) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1685231) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" /label="downshifts" CDS 1685295..1685555 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" /label="spoVS CDS" gene 1685295..1685555 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /label="spoVS gene" downshifts 1685507 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts complement(1685539) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" /label="downshifts" downshifts 1685551 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1685596..1685770 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1685754..1685761 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1685772 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1685776..1685795 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1685821..1686864 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" /label="tdh CDS" gene 1685821..1686864 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /label="tdh gene" CDS 1686877..1688055 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" /label="kbl CDS" gene 1686877..1688055 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /label="kbl gene" downshifts 1688037 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" promotor_-35 1688135..1688138 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1688147 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1688153..1688172 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1688203..1689732 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" /label="miaB CDS" gene 1688203..1689732 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /label="miaB gene" CDS 1689734..1690165 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" /label="ricA CDS" gene 1689734..1690165 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /label="ricA gene" downshifts 1690148 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1690296..1690301 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1690317..1690335 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1690325..1690426 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1690325 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="upshifts" CDS 1690427..1690972 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" /label="cotE CDS" gene 1690427..1690972 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /label="cotE gene" downshifts 1690966 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" /label="downshifts" downshifts complement(1690973) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" /label="downshifts" promotor_-35 1691030..1691033 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1691048..1691067 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1691052 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="upshifts" CDS 1691105..1693681 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" /label="mutS CDS" gene 1691105..1693681 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /label="mutS gene" CDS 1693697..1695580 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" /label="mutL CDS" gene 1693697..1695580 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /label="mutL gene" S_feature complement(1695483..1695977) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S611" downshifts 1695495 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1695505) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1695727..1695734 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1695749..1695768 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1695759..1695892 /Source="Nicolas_S_feature" /locus_tag="new_1780399_1780532" /HighExp="LoTm, T0.30H, T1.30H, M9-stat, T3.0H, BC, T1.0H, B60, B36, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99494800000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S612" upshifts 1695759 /Source="Nicolas_upshifts" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1695764..1695914) /gene="surX" /locus_tag="BSU_misc_RNA_89" /product="small untranslated RNA of unknown function" /note="Evidence 5: Unknown function; PubMedId : 20525796, 23155385" /label="surX RNA" gene complement(1695764..1695914) /gene="surX" /locus_tag="BSU_misc_RNA_89" /label="surX gene" downshifts 1695849 /Source="Nicolas_upshifts" /id="D925" /incds=0 /nref=19 /ntot=136 /MaxReadThrough="3.45962" /MaxDrop="4.12444" /score="29.4045648" /energy="-15.3" /TU="U1365" /idTUdmin="U1364" /TUdmin=354 /isTUend="FALSE" /label="downshifts" CDS complement(1695978..1696433) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="YP_054578.1" /db_xref="EnsemblGenomes-Gn:BSU17060" /db_xref="EnsemblGenomes-Tr:CAE01453" /db_xref="GOA:Q7WY71" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14188" /db_xref="UniProtKB/Swiss-Prot:Q7WY71" /translation="MNQKEQNEHSKDFNLRSKLIGIVSITFIAAIALAVIFGGFFFGM KGLFSILGITYASNQTLALFILACFAVGLIIDPLTKIISIILAKSLSLKKTALFAFIL YFISNLITICFADYFMQSIYIPDVLLVVISAFMAIIELAFDNQPNREAA*" /label="ymzD CDS" gene complement(1695978..1696433) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /label="ymzD gene" S_feature complement(1696434..1696525) /Source="Nicolas_S_feature" /locus_tag="new_1781074_1781165_c" /HighExp="LBGstat, M9-stat, T1.0H, T1.30H, T2.0H, M0t90, MG 150, LPhT, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S613" promotor_-10 complement(1696513..1696532) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1696525) /Source="Nicolas_upshifts" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1696549..1696552) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1696588..1697145) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389588.1" /db_xref="EnsemblGenomes-Gn:BSU17070" /db_xref="EnsemblGenomes-Tr:CAB13579" /db_xref="GOA:O31780" /db_xref="SubtiList:BG13419" /db_xref="UniProtKB/Swiss-Prot:O31780" /translation="MNGIAWMIVFCEIAFWVVIVLGLAVRYVFKRHTLGLLFLALTPV IDLILLAATGVDLYRGASATAAHGIAAVYIGISIAYGKQMIQWADEKFQYYVTKKGTK PLKRFGMDHAKHGAKGWLRHVLAYLIGAGLLAGMIYFINDSSRTEALSGILKLWTVII GIDFLITASYFIWPKKEKASANLRS*" /label="ymcC CDS" gene complement(1696588..1697145) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /label="ymcC gene" promotor_-35 1697229..1697236 /Source="Nicolas_upshift_promotors" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1697249..1697268 /Source="Nicolas_upshift_promotors" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1697251..1697269) /Source="Nicolas_upshift_promotors" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1697254 /Source="Nicolas_upshifts" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1697265) /Source="Nicolas_upshifts" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1697266..1697403 /created_by="AR/SM" /note="N-terminus of previously known orfA is fused to a chromosomal 3`sequence resulting in an artificial C-terminal extension of the truncated protein A, transcription and translation is driven from known promoters and SD of orfA " /locus_tag="Delta6_BSU_17080-art" /modified_by="stephanmichalik" /transl_table=11 /pseudo /translation="MPKQIDHEKRRKQIAEATWRVILERGMEGASARNIAKEAGLSLE A*" /label="Delta6_BSU_17080-art" gene 1697266..1697403 /created_by="AR/SM" /note="N-terminus of previously known orfA is fused to a chromosomal 3`sequence resulting in an artificial C-terminal extension of the truncated protein A, transcription and translation is driven from known promoters and SD of orfA " /locus_tag="Delta6_BSU_17080-art" /label="Delta6_BSU_17080-art" promotor_-35 complement(1697284..1697289) /Source="Nicolas_upshift_promotors" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1697381,1698444) /created_by="User" /modified_by="User" /label="Delta5" N_region 1697382..1698443 /note="insertion of sequence with unknown origin - insert contains an independent promoter SD and chloramphenicol resistance gene" /created_by="User" /label="Delta5" promotor_-35 1697397..1697404 /Source="Nicolas_upshift_promotors" /id="U1370" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.993006993006993" /xcortree=556 /SigmaFactorBS="gcagaaaaacaatggagcaaactgtaggaaaaattAACTTGA CggataatatttacaGAGGTTACCATCAACATGAAcatgctactatttatccggtcat c" /listShort="S616, pksC, S617, pksD, pksE, acpK, pksF, pksG, pksH, pksI, pksJ, pksL, pksM, pksN, pksR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1697600..1697605 /created_by="User" /label="Delta5_SigA_-35" promotor_-10 1697623..1697628 /created_by="User" /label="Delta5_SigA_-10" CDS 1697692..1698411 /gene="catA" /locus_tag="A8O17_RS08865" /old_locus_tag="A8O17_08865" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_032488880.1" /note="frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology." /pseudo /codon_start=1 /transl_table=11 /product="type A chloramphenicol O-acetyltransferase" /modified_by="User" /translation="MNFNKIDLDNWKRKEIFNHYLNQQTTFSITTEIDISVLYRNIKQ EGYKFYPAFIFLVTRVINSNTAFRTGYNSDGELGYWDKLEPLYTIFDGVSKTFSGIWT PVKNDFKEFYDLYLSDVEKYNGSGKLFPKTPIPENAFSLSIIPWTSFTGFNLNINNNS NYLLPIITAGKFINKGNSIYLPLSLQVHHSVCDGYHAGLFMNSIQELSDRPNDWLL*Y EIMPTVLFTVGFLMSLTCPVS*" /label="Delta6_NEW_001" gene 1697692..1698411 /gene="catA" /locus_tag="A8O17_RS08865" /old_locus_tag="A8O17_08865" /pseudo /modified_by="User" /label="Delta6_NEW_001" CDS 1698444..1698926 /note="pseudogene - residual C-terminal sequence due to internal deletion scar" /created_by="AR/SM" /locus_tag="Delta6_pseudo_BSU_17220" /modified_by="stephanmichalik" /transl_table=11 /pseudo /translation="EFLSELIDLAKERGLNKPDKQIRAQAQQMMKTQRAYDLESYTVK PLPDPETVKCYYFRNKSRSFFGDLDTYFTLSNEKEPFDQAAYWEEWERQIPHFHLVDV DSSNHFMILTEPKASTALLEFCEKLYSNRGVVNANFLKAFRKKHEAREEKETDELVKR *" /label="Delta6_pseudo_BSU_17220" gene 1698444..1698926 /note="pseudogene - residual C-terminal sequence due to internal deletion scar " /created_by="AR/SM" /modified_by="User" /locus_tag="Delta6_pseudo_BSU_17220" /label="Delta6_pseudo_BSU_17220" downshifts 1698915 /Source="Nicolas_upshifts" /id="D927" /incds=0 /nref=65 /ntot=216 /MaxReadThrough="0.92789" /MaxDrop="5.77685" /score="4.87908333" /energy="-14.6" /TU="NA" /idTUdmin="U1370" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1698971..1700188) /gene="pksS" /locus_tag="BSU_17230" /old_locus_tag="BSU17230" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 17482575, 16707694, 17234808, 17886826, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 of bacillaene metabolism" /protein_id="NP_389605.2" /db_xref="EnsemblGenomes-Gn:BSU17230" /db_xref="EnsemblGenomes-Tr:CAB13607" /db_xref="GOA:O31785" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4YZR" /db_xref="SubtiList:BG12655" /db_xref="UniProtKB/Swiss-Prot:O31785" /translation="MEKLMFHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATYPA WLITRYDDCMAFLKDNRITRDVKNVMNQEQIKMLNVSEDIDFVSDHMLAKDTPDHTRL RSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKENKADIMKSFASPLPFIVISELMGI PKEDRSQFQIWTNAMVDTSEGNRELTNQALREFKDYIAKLIHDRRIKPKDDLISKLVH AEENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIAT AVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEILN INRSPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAPDDIQWRKNVF LRGLESLPVSLSK*" /label="pksS CDS" gene complement(1698971..1700188) /gene="pksS" /locus_tag="BSU_17230" /old_locus_tag="BSU17230" /label="pksS gene" downshifts complement(1698990) /Source="Nicolas_upshifts" /id="D928" /incds=0 /nref=123 /ntot=225 /MaxReadThrough="0.911470000000001" /MaxDrop="4.23567" /score="16.9796453" /energy="-16.8" /TU="NA" /idTUdmin="U1373" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(1700203..1700303) /Source="Nicolas_upshift_promotors" /id="U1372" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.53046953046953" /psig="0.297702297702298" /xcortree=1727 /SigmaFactorBS="ctaagatagatatatagttttagagacaggattacatttcaa atcattctgttttttgtaaactaattcagcaatttgattcatctatttaccctattag g" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1700243) /Source="Nicolas_upshifts" /id="U1372" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.53046953046953" /psig="0.297702297702298" /xcortree=1727 /SigmaFactorBS="ctaagatagatatatagttttagagacaggattacatttcaa atcattctgttttttgtaaactaattcagcaatttgattcatctatttaccctattag g" /listShort="pksS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1700275..1700294) /Source="Nicolas_upshift_promotors" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1700287) /Source="Nicolas_upshifts" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1700289..1700369) /Source="Nicolas_S_feature" /locus_tag="new_1859884_1859964_c" /HighExp="Salt, Etha, T-3.40H, T-0.40H, T-1.40H, LoTm, T-2.40H, S1, SMM, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.122" /TUlongSig="NA" /TUlongPSig="NA" /label="S618" promotor_-35 complement(1700309..1700316) /Source="Nicolas_upshift_promotors" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1700413) /Source="Nicolas_upshifts" /id="D929" /incds=0 /nref=24 /ntot=184 /MaxReadThrough="3.69744" /MaxDrop="5.18486" /score="-0.71313204" /energy="-20.1" /TU="U1374" /idTUdmin="U1375" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(1700419..1700775) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11544224, 15805528, 20817675" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function involved in ethanol resistance" /protein_id="NP_389606.3" /db_xref="EnsemblGenomes-Gn:BSU17240" /db_xref="EnsemblGenomes-Tr:CAB13608" /db_xref="SubtiList:BG13435" /db_xref="UniProtKB/Swiss-Prot:O31786" /translation="MAHTNTQLSQWLESKVGQTLDIRKGELTHDEEISDLDQIVLHLQ KVAIRSTNHPDDYVAKEELVLEGEGTTFTEDGNVPLPQNAYEIPLLGELHIHQENEGL KVVTDRAVYTIDIQHS*" /label="ymzB CDS" gene complement(1700419..1700775) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /label="ymzB gene" misc_feature complement(1700835..1700848) /Source="Nicolas_upshift_promotors" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1700840) /Source="Nicolas_upshifts" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1700854..1701678) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20817675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389607.2" /db_xref="EnsemblGenomes-Gn:BSU17250" /db_xref="EnsemblGenomes-Tr:CAB13609" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13413" /db_xref="UniProtKB/Swiss-Prot:O31787" /translation="MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLE DMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTID QINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETL NMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLI PLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT*" /label="ymaE CDS" gene complement(1700854..1701678) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /label="ymaE gene" promotor_-10 complement(1701700..1701719) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1701716) /Source="Nicolas_upshifts" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1701731..1701737) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1701789..1703117) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10589719, 16267290, 17884659, 28693413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10589719, 16267290, 17884659, 28693413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline serine protease" /protein_id="NP_389608.1" /db_xref="EnsemblGenomes-Gn:BSU17260" /db_xref="EnsemblGenomes-Tr:CAB13610" /db_xref="GOA:O31788" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG12567" /db_xref="UniProtKB/Swiss-Prot:O31788" /translation="MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFE TKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSAL HSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYP HPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGV KVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRA VEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSS RGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAG IAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ*" /label="aprX CDS" gene complement(1701789..1703117) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /label="aprX gene" downshifts complement(1701796) /Source="Nicolas_upshifts" /id="D930" /incds=0 /nref=13 /ntot=21 /MaxReadThrough="2.43809" /MaxDrop="5.8915" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1376" /TUdmin=8 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1703140..1703159) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1703159) /Source="Nicolas_upshifts" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1703173..1703181) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1703274..1703281 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1703289..1703308) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1703297..1703316 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1703300) /Source="Nicolas_upshifts" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" upshifts 1703303 /Source="Nicolas_upshifts" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1703321..1703328) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1703342..1703419 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of YmzE" /translation="MNFYLHRSLESQMPISIIYEERRND*" /label="ymzEn CDS" gene 1703342..1703419 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /pseudo /label="ymzEn gene" downshifts complement(1703344) /Source="Nicolas_upshifts" /id="D931" /incds=0 /nref=4 /ntot=7 /MaxReadThrough="1.51659" /MaxDrop="5.37668" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1377" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS 1703397..1703573 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of YmzE" /db_xref="PSEUDO:CAX52622.1" /translation="MKKDGTISKRTIIVRQKSKTKIKAFCFSKQQIRTFLLDSILSCD FVRTNKQNLYSAGR*" /label="ymzEc CDS" gene 1703397..1703573 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /pseudo /label="ymzEc gene" downshifts 1703554 /Source="Nicolas_upshifts" /id="D932" /incds=0 /nref=42 /ntot=207 /MaxReadThrough="4.03151" /MaxDrop="6.55778" /score="-0.929304655" /energy="-5.5" /TU="U1378" /idTUdmin="U1378" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature 1703599..1703787 /Source="Nicolas_S_feature" /locus_tag="new_1863194_1863382" /HighExp="H2O2, M40t90, C90, M40t45, C30, S8, HiOs, G135, T-4.40H, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S619" misc_feature 1703782..1703801 /Source="Nicolas_upshift_promotors" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1703789 /Source="Nicolas_upshifts" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1703853..1704560 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16267290, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="gamma-polyglutamate hydrolase (phage origin)" /protein_id="NP_389609.1" /db_xref="EnsemblGenomes-Gn:BSU17270" /db_xref="EnsemblGenomes-Tr:CAB13611" /db_xref="GOA:O31789" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13411" /db_xref="UniProtKB/Swiss-Prot:O31789" /translation="MRRFLLNVILVLAIVLFLRYVHYSLEPEPSNQPDTYSNFSSLAE NESPADYDISYNEKKGSKVLIMSPHGGRIEGGVSELVRYFNNEYSTYLFEGLKSHDNQ TLHITSTNFDEPLAKKKIKEHQYVVAFHGYKGENKNTLVGGTDRKRAKMIVRALERRG FSAELASSKSGLAGLNAENINNQGETGLSIQLEISREQREAFFDDFYYKNRKYTKNSE FYAYVSAIKGVLEKEYS*" /label="pghC CDS" gene 1703853..1704560 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /label="pghC gene" promotor_-35 1704571..1704577 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1704591..1704610 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1704595 /Source="Nicolas_upshifts" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1704630..1705082 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290, 22904090, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peroxiredoxin-related protein" /protein_id="NP_389610.1" /db_xref="EnsemblGenomes-Gn:BSU17280" /db_xref="EnsemblGenomes-Tr:CAB13612" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019905" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13412" /db_xref="UniProtKB/Swiss-Prot:O31790" /translation="MADHHFYLKANWPGNRNDVGTIESGNLITSISIPKEMDGPGEGT NPDEMLLGAAATCYIITLAAMMERSGLEKEDLQMESEGIVNVTKGVFTYKKIIHRPSV VLKHDASQDDVALAHKLCKKAESSCMISRAIQGNVELQLEASVKLGGE*" /label="ymaD CDS" gene 1704630..1705082 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /label="ymaD gene" downshifts 1705070 /Source="Nicolas_upshifts" /id="D933" /incds=0 /nref=44 /ntot=182 /MaxReadThrough="1.35366" /MaxDrop="6.07534" /score="17.0193804" /energy="-12.1" /TU="NA" /idTUdmin="U1379" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1705096..1705449) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 15849754, 16750162, 16850406, 18024586, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 15849754, 16750162, 16850406, 18024586, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389611.1" /db_xref="EnsemblGenomes-Gn:BSU17290" /db_xref="EnsemblGenomes-Tr:CAB13613" /db_xref="GOA:P0CW82" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12586" /db_xref="UniProtKB/Swiss-Prot:P0CW82" /translation="MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAF TFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLN QSKAHAEDKKQTACE*" /label="ebrB CDS" gene complement(1705096..1705449) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /label="ebrB gene" downshifts complement(1705137) /Source="Nicolas_upshifts" /id="D934" /incds=0 /nref=2 /ntot=45 /MaxReadThrough="0.84905" /MaxDrop="2.87924" /score="-2.89884673" /energy="-8.7" /TU="NA" /idTUdmin="U1381" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1705463..1705780) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 11104814, 17516673, 18024586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 11104814, 17516673, 18024586; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389612.1" /db_xref="EnsemblGenomes-Gn:BSU17300" /db_xref="EnsemblGenomes-Tr:CAB13614" /db_xref="GOA:P0CW80" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12585" /db_xref="UniProtKB/Swiss-Prot:P0CW80" /translation="MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLA FYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLL NWP*" /label="ebrA CDS" gene complement(1705463..1705780) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /label="ebrA gene" promotor_-10 complement(1705824..1705843) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1705832) /Source="Nicolas_upshifts" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1705858..1705865) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1705917..1706192) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAPFPFYY*" /label="ymaG CDS" gene complement(1705917..1706192) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /label="ymaG gene" downshifts complement(1705918) /Source="Nicolas_upshifts" /id="D935" /incds=0 /nref=38 /ntot=44 /MaxReadThrough="0.28059" /MaxDrop="8.33353" /score="12.3408391" /energy="-11.5" /TU="NA" /idTUdmin="U1383" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1706188..1706193 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1706209..1706227 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1706219..1706238) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1706229 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="upshifts" upshifts complement(1706232) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1706251..1706260) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1706281..1706694 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" /label="ymaF CDS" gene 1706281..1706694 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /label="ymaF gene" upshifts 1706745 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="upshifts" misc_feature 1706751..1706770 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1706794..1707738 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" /label="miaA CDS" gene 1706794..1707738 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /label="miaA gene" promotor_-35 1707718..1707726 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1707737..1707755 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1707739 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="upshifts" CDS 1707778..1707999 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" /label="hfq CDS" gene 1707778..1707999 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /label="hfq gene" downshifts complement(1707789) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1707851..1707855) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1707855) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1707870..1707875) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1707999 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1708195..1708467 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" /label="ymzC CDS" gene 1708195..1708467 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /label="ymzC gene" promotor_-35 1708483..1708490 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1708504..1708523 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1708506 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="upshifts" CDS 1708549..1708779 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" /label="ymzA CDS" gene 1708549..1708779 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /label="ymzA gene" S_feature 1708780..1708856 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1708813 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 1708858..1708965 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1708938..1708945 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1708959..1708978 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1708967 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="upshifts" CDS 1709022..1709414 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" /label="nrdI CDS" gene 1709022..1709414 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /label="nrdI gene" CDS 1709374..1711476 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" /label="nrdE CDS" gene 1709374..1711476 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /label="nrdE gene" CDS 1711494..1712483 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" /label="nrdF CDS" gene 1711494..1712483 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /label="nrdF gene" downshifts 1712443 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(1712497..1713156) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1712512) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 1712533..1713153 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" /label="ymaB CDS" gene 1712533..1713153 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /label="ymaB gene" downshifts 1713134 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" /label="downshifts" promotor_-35 1713169..1713173 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1713191..1713558 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1713191 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1713195..1713212 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1713201) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS complement(1713217..1713984) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" /label="cwlC CDS" gene complement(1713217..1713984) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /label="cwlC gene" promotor_-10 complement(1713993..1714012) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1714016) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1714025..1714034) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1714138..1714143 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1714159..1714177 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1714159 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1714441..1714446 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1714463..1714481 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1714467..1714607 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1714467 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="upshifts" CDS 1714608..1715576 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" /label="spoVK CDS" gene 1714608..1715576 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /label="spoVK gene" downshifts 1715545 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-35 1715640..1715648 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1715655 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="upshifts" promotor_-10 1715659..1715678 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1715709..1716971 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" /label="hflX CDS" gene 1715709..1716971 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /label="hflX gene" CDS 1716989..1718254 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" /label="ynbB CDS" gene 1716989..1718254 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /label="ynbB gene" promotor_-35 1718302..1718309 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1718324..1718343 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1718336 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="upshifts" CDS 1718364..1718771 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" /label="glnR CDS" gene 1718364..1718771 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /label="glnR gene" downshifts complement(1718370) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" /label="downshifts" misc_feature 1718752..1718770 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1718777 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1718830) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" /label="downshifts" CDS 1718830..1720164 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" /label="glnA CDS" gene 1718830..1720164 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /label="glnA gene" downshifts 1720141 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature 1720186..1720446 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" promotor_-35 1720421..1720428 /Source="Nicolas_upshift_promotors" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1720443..1720462 /Source="Nicolas_upshift_promotors" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1720448 /Source="Nicolas_upshifts" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="upshifts" CDS 1720492..1720782 /gene="ynxB" /locus_tag="BSU_17470" /old_locus_tag="BSU17470" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective, phage region" /protein_id="NP_389629.1" /db_xref="EnsemblGenomes-Gn:BSU17470" /db_xref="EnsemblGenomes-Tr:CAB13631" /db_xref="GOA:P31844" /db_xref="SubtiList:BG11074" /db_xref="UniProtKB/Swiss-Prot:P31844" /translation="MKKLTIFSGGLGAVFSVLAQLFAVIDDSYTLGNLWFLGALAGII TMLASIQTNNKPVFSILLIASSVIGLLGTGLVYIIPTLFNIIIIYKFSKVSQ*" /label="ynxB CDS" gene 1720492..1720782 /gene="ynxB" /locus_tag="BSU_17470" /old_locus_tag="BSU17470" /label="ynxB gene" S_feature 1720783..1721027 /Source="Nicolas_S_feature" /locus_tag="new_1880378_1880622" /HighExp="Cold, M9-stat, BC, B60, LPhT, T0.30H, LBGstat, LoTm, S4, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.49198399999999998" /TUshortSig="SigA, SigL, SigA" /TUshortPSig="0.997, 0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S626" CDS 1721028..1721372 /gene="ynzF" /locus_tag="BSU_17480" /old_locus_tag="BSU17480" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389630.1" /db_xref="EnsemblGenomes-Gn:BSU17480" /db_xref="EnsemblGenomes-Tr:CAB13632" /db_xref="SubtiList:BG13469" /db_xref="UniProtKB/Swiss-Prot:O31799" /translation="MWKALSQLLKKQKNQSPSDEDYIQIPELEVKVLGMLHSINIDLV NVIAQAEKSKEFIGQIEGIWHSIANQFYSLAQGFENEDINKLSADLDHAAATWEAVAN KAKEFVTNSYQG*" /label="ynzF CDS" gene 1721028..1721372 /gene="ynzF" /locus_tag="BSU_17480" /old_locus_tag="BSU17480" /label="ynzF gene" downshifts 1721350 /Source="Nicolas_upshifts" /id="D947" /incds=0 /nref=31 /ntot=125 /MaxReadThrough="3.06401" /MaxDrop="4.27622" /score="-0.54122646" /energy="-8.3" /TU="U1394,U1396" /idTUdmin="U1394" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS 1721503..1721754 /gene="ynzG" /locus_tag="BSU_17490" /old_locus_tag="BSU17490" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389631.1" /db_xref="EnsemblGenomes-Gn:BSU17490" /db_xref="EnsemblGenomes-Tr:CAB13633" /db_xref="SubtiList:BG13470" /db_xref="UniProtKB/Swiss-Prot:O31800" /translation="MLGINVEKSNENLIINWQLSKIEIPIKEINDVFLDPNYGGEEKS AVRIGFPYGSTDRVVIKTARNTYILFTTNPALIMSKIVS*" /label="ynzG CDS" gene 1721503..1721754 /gene="ynzG" /locus_tag="BSU_17490" /old_locus_tag="BSU17490" /label="ynzG gene" promotor_-35 1721780..1721787 /Source="Nicolas_upshift_promotors" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1721798..1721817 /Source="Nicolas_upshift_promotors" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1721811..1721940 /Source="Nicolas_S_feature" /locus_tag="new_1881406_1881535" /HighExp="LoTm, Etha, LPhT, B60, M9-stat, T3.0H, T3.30H, Salt, T4.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.968584" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.997, 1, 1" /label="S627" upshifts 1721811 /Source="Nicolas_upshifts" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1721941..1722375 /gene="ynaB" /locus_tag="BSU_17500" /old_locus_tag="BSU17500" /function="17.2: Prophage functions" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389632.2" /db_xref="EnsemblGenomes-Gn:BSU17500" /db_xref="EnsemblGenomes-Tr:CAB13634" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG12254" /db_xref="UniProtKB/Swiss-Prot:P94480" /translation="MEDATFHFKDPASPQEISDIEQKLGVTFPNDYKEFLLQHNGMEM FDGIEILSLEGIIEYNEVQDFPEGYVLIGYHFDGRYVIDTNKSKNGLGYMLYLDSIDD IEDAINLDSNFEIWFDMLVSLNGTKYWEVNPNLQEYYKLVSE*" /label="ynaB CDS" gene 1721941..1722375 /gene="ynaB" /locus_tag="BSU_17500" /old_locus_tag="BSU17500" /label="ynaB gene" CDS 1722445..1723236 /gene="ynaC" /locus_tag="BSU_17510" /old_locus_tag="BSU17510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389633.1" /db_xref="EnsemblGenomes-Gn:BSU17510" /db_xref="EnsemblGenomes-Tr:CAB13635" /db_xref="SubtiList:BG12255" /db_xref="UniProtKB/Swiss-Prot:P94481" /translation="MTIYEQIKDALKNKINELVSPQEVKKTLQEKYGTNPDSIILSDY CYNRYNKGISFNKHLFEYMNRSSYKYLGENSLYTGLIFRKSKGEDKEVIVGEWVNGVK SLREASVTNNQINDQAEIISKEQLVNLYNEYNQILRYEMNVLNCKPTELRHLIGRIGE FICAIQTNGTLARQTNQHGFDVVSDGRRISVKTTAQSSGFISINKNTFYDFDDFFVVQ YVNDDFKVIFFGSKEEVQKISRIYGSQYEVEISLLKKLNKEYQLN*" /label="ynaC CDS" gene 1722445..1723236 /gene="ynaC" /locus_tag="BSU_17510" /old_locus_tag="BSU17510" /label="ynaC gene" promotor_-10 complement(1722553..1722572) /Source="Nicolas_upshift_promotors" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1722561) /Source="Nicolas_upshifts" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1722588..1722590) /Source="Nicolas_upshift_promotors" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1723232 /Source="Nicolas_upshifts" /id="D948" /incds=0 /nref=10 /ntot=182 /MaxReadThrough="4.47202" /MaxDrop="6.29359" /score="3.60743536" /energy="-14.4" /TU="U1397" /idTUdmin="U1397" /TUdmin="-836" /isTUend="FALSE" /label="downshifts" downshifts 1723298 /Source="Nicolas_upshifts" /id="D949" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="3.36892" /MaxDrop="4.40772" /score="3.60743536" /energy="-14.4" /TU="U1397" /idTUdmin="U1397" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 1723509..1723517 /Source="Nicolas_upshift_promotors" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1723529..1723547 /Source="Nicolas_upshift_promotors" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1723540 /Source="Nicolas_upshifts" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1723571..1724083 /gene="ynaD" /locus_tag="BSU_17520" /old_locus_tag="BSU17520" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase; putative phage region" /protein_id="NP_389634.1" /db_xref="EnsemblGenomes-Gn:BSU17520" /db_xref="EnsemblGenomes-Tr:CAB13636" /db_xref="GOA:P94482" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12256" /db_xref="UniProtKB/Swiss-Prot:P94482" /translation="MHITTKRLLIREFEFKDWQAVYEYTSDSNVMKYIPEGVFTEEDA KAFVNKNKGDNAEKFPVILRDEDCLIGHIVFYKYFGEHTYEIGWVFNPNYQNKGYASE AAQAILEYGFKEMNLHRIIATCQPENIPSYRVMKKIGMRREGFFKKCIPKGNEWWDEY YYAILEEEWN*" /label="ynaD CDS" gene 1723571..1724083 /gene="ynaD" /locus_tag="BSU_17520" /old_locus_tag="BSU17520" /label="ynaD gene" promotor_-35 1724530..1724536 /Source="Nicolas_upshift_promotors" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1724530 /Source="Nicolas_upshifts" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1724532..1724536 /Source="Nicolas_upshift_promotors" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1724550..1724569 /Source="Nicolas_upshift_promotors" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1724550..1724569 /Source="Nicolas_upshift_promotors" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1724574..1724642 /Source="Nicolas_S_feature" /locus_tag="new_1884169_1884237" /HighExp="T1.30H, M9-stat, Lbtran, M0t90, T0.30H, T1.0H, T2.30H, Lbstat, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S628" upshifts 1724574 /Source="Nicolas_upshifts" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" /label="upshifts" CDS 1724643..1725284 /gene="ynaE" /locus_tag="BSU_17530" /old_locus_tag="BSU17530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389635.1" /db_xref="EnsemblGenomes-Gn:BSU17530" /db_xref="EnsemblGenomes-Tr:CAB13637" /db_xref="InterPro:IPR024976" /db_xref="SubtiList:BG12257" /db_xref="UniProtKB/Swiss-Prot:P94483" /translation="MNLIGYIEERFQNLELIPSIYNQWGTGIHFCLGENIYQLKANEE LNLKMFRIVYEQTSIIFNELFEQNDDIFLVTNMYKHKKKEKCIRKLKVYQPFLKCKNH LNQIMVKTYPYPFEINKAEEYEMQQFSLLCKPRDLRVTELLKAASNEDFPQKPKFGGY SIDYPDVFFVNITKDIIFFIYDDRGCEVIAHDFKRIRPLYEKYHDWVEEYKCM*" /label="ynaE CDS" gene 1724643..1725284 /gene="ynaE" /locus_tag="BSU_17530" /old_locus_tag="BSU17530" /label="ynaE gene" S_feature 1725285..1725372 /Source="Nicolas_S_feature" /locus_tag="new_1884880_1884967" /HighExp="M0t90, Lbtran, Lbstat, T1.30H, S2, T1.0H, T0.30H, MG 150, M9-stat, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S629" CDS 1725373..1725726 /gene="ynaF" /locus_tag="BSU_17540" /old_locus_tag="BSU17540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389636.1" /db_xref="EnsemblGenomes-Gn:BSU17540" /db_xref="EnsemblGenomes-Tr:CAB13638" /db_xref="SubtiList:BG12258" /db_xref="UniProtKB/Swiss-Prot:P94484" /translation="MVLCDDERSAFLLVLDERLVDFDSQGGNHISVYLVTHFELSDQS YKDVLSFNDDLLGMEHNCSYAMDILSVKEELDFDFPFNMLAIKSYVQELIKMLGIDIT LPEMKERDFDKLSQN*" /label="ynaF CDS" gene 1725373..1725726 /gene="ynaF" /locus_tag="BSU_17540" /old_locus_tag="BSU17540" /label="ynaF gene" CDS 1725770..1726045 /gene="ynaG" /locus_tag="BSU_17550" /old_locus_tag="BSU17550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389637.1" /db_xref="EnsemblGenomes-Gn:BSU17550" /db_xref="EnsemblGenomes-Tr:CAB13639" /db_xref="GOA:P94485" /db_xref="SubtiList:BG12259" /db_xref="UniProtKB/Swiss-Prot:P94485" /translation="MNVKKAAAVFSITIPIISAILIINFFTGFMSIPWQGMPVFFPLL LSPIGIILAFVSIKTNKRCAVYGIVLNAIMFPFPFFWFIGGALLFGV*" /label="ynaG CDS" gene 1725770..1726045 /gene="ynaG" /locus_tag="BSU_17550" /old_locus_tag="BSU17550" /label="ynaG gene" downshifts complement(1726146) /Source="Nicolas_upshifts" /id="D950" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="1.74772" /MaxDrop="3.30031" /score="-7.48025946" /energy="-14.4" /TU="NA" /idTUdmin="U1402" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS 1726158..1726322 /gene="ynzI" /locus_tag="BSU_17559" /old_locus_tag="BSU17559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="YP_003097730.1" /db_xref="EnsemblGenomes-Gn:BSU17559" /db_xref="EnsemblGenomes-Tr:CAX52623" /db_xref="GOA:C0H415" /db_xref="UniProtKB/Swiss-Prot:C0H415" /translation="MDRKKDEIQRKYREQMREKKEREKEDGSSHTFEIVVVLAIIILM FFFNSVFKAF*" /label="ynzI CDS" gene 1726158..1726322 /gene="ynzI" /locus_tag="BSU_17559" /old_locus_tag="BSU17559" /label="ynzI gene" S_feature 1726323..1726461 /Source="Nicolas_S_feature" /locus_tag="new_1885918_1886056" /HighExp="M0t90, Lbstat, S1, Lbtran, S2, M40t90, T1.30H, Glu, T1.0H, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S630" CDS 1726462..1726932 /gene="ynaI" /locus_tag="BSU_17560" /old_locus_tag="BSU17560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389638.3" /db_xref="EnsemblGenomes-Gn:BSU17560" /db_xref="EnsemblGenomes-Tr:CAB13640" /db_xref="SubtiList:BG12261" /db_xref="UniProtKB/Swiss-Prot:P94487" /translation="MKLYNEFINIAKTFNKELDIIPLLYGSLGLEKVTGLDFSPEDID LLIPLIFLEEKWEKLKKVMELHGYKMVDLHEHEFKKTNTKIGISYIEDLKPFADVDYN NLEIFEDGGAKYHLLTIDDYLKIYKKSLLDGYRRRKKNHKDQSKINILNKLIRN*" /label="ynaI CDS" gene 1726462..1726932 /gene="ynaI" /locus_tag="BSU_17560" /old_locus_tag="BSU17560" /label="ynaI gene" S_feature 1726933..1727756 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1727096..1727114) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1727114) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1727130..1727135) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1727757..1729148 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" /label="xynP CDS" gene 1727757..1729148 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /label="xynP gene" CDS 1729179..1730780 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" /label="xynB CDS" gene 1729179..1730780 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /label="xynB gene" S_feature complement(1729295..1729600) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1729595..1729614) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1729600) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1729628..1729636) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1730778 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" /label="downshifts" CDS complement(1730917..1732071) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" /label="xylR CDS" gene complement(1730917..1732071) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /label="xylR gene" downshifts complement(1730920) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1731970..1732148) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1732116..1732122 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1732131..1732150) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1732132..1732148 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1732142 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1732148) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1732165..1732168) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1732175..1732182 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1732197..1732216 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1732208..1732312 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1732209 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="upshifts" CDS 1732313..1733650 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" /label="xylA CDS" gene 1732313..1733650 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /label="xylA gene" S_feature 1733651..1733725 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1733682 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" CDS 1733801..1735300 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" /label="xylB CDS" gene 1733801..1735300 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /label="xylB gene" S_feature 1735301..1735616 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1735574 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1735783..1736418) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" /label="yncB CDS" gene complement(1735783..1736418) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /label="yncB gene" promotor_-10 complement(1736455..1736474) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1736464) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1736489..1736496) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1736606..1736613 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1736628..1736647 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1736630..1736828 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1736630 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="upshifts" CDS 1736829..1738244 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" /label="yncC CDS" gene 1736829..1738244 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /label="yncC gene" downshifts 1738234 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1738337) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1738346..1739530) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" /label="alrB CDS" gene complement(1738346..1739530) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /label="alrB gene" S_feature complement(1739531..1739610) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1739603..1739621) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1739614) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1739637..1739642) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1739922..1739929 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1739944..1739963 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1739952 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1739994..1740455 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" /label="yncE CDS" gene 1739994..1740455 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /label="yncE gene" CDS 1740485..1740919 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" /label="dutA CDS" gene 1740485..1740919 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /label="dutA gene" S_feature complement(1740668..1740973) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1740766 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" S_feature 1740920..1742016 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1740975..1741260) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1741018) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1741255..1741274) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1741260) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1741286..1741291) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1741522) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1741522..1741782) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" /label="cotU CDS" gene complement(1741522..1741782) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /label="cotU gene" promotor_-10 complement(1741803..1741822) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1741813) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1741835..1741844) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1742017..1742142 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" /label="ynzJ CDS" gene 1742017..1742142 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo /label="ynzJ gene" S_feature 1742143..1742259 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1742186..1742350 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" /label="conserved hypothetical protein from phage origin CDS" gene 1742186..1742350 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /label="gene" promotor_-35 1742234..1742243 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1742257..1742276 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1742261..1742571 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1742261 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1742552..1742559 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1742573..1742592 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1742573 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1742624..1743463 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" /label="thyA CDS" gene 1742624..1743463 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /label="thyA gene" promotor_-10 complement(1742646..1742665) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1742667) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1742680..1742683) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1743423 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts complement(1743569) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature complement(1743570..1743876) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1743586..1743873) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" /label="conserved protein of unknown function CDS" gene complement(1743586..1743873) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /label="gene" downshifts complement(1743613) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1743700..1743708 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1743722..1743741 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1743724 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="upshifts" S_feature 1743735..1743895 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1743867 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1743916..1744638) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" /label="yncM CDS" gene complement(1743916..1744638) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /label="yncM gene" downshifts complement(1743921) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1744663..1744682) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1744671) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1744673..1744797) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1744798..1745154) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" /label="ynzK CDS" gene complement(1744798..1745154) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /label="ynzK gene" promotor_-10 complement(1745178..1745197) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1745195) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1745213..1745217) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1745394) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1745400..1745600) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" /label="cotC CDS" gene complement(1745400..1745600) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /label="cotC gene" downshifts 1745583 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1745622..1745641) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1745634) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1745654..1745663) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1745775..1745963) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" /label="tatAC CDS" gene complement(1745775..1745963) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /label="tatAC gene" downshifts complement(1745791) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" misc_feature complement(1745932..1745939) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1745945) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1745992..1746011) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1746010) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1746026..1746033) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1746042..1746179 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" /label="hypothetical protein CDS" gene 1746042..1746179 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /label="gene" promotor_-35 1746073..1746078 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1746093..1746111 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1746111..1746213 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1746111 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="upshifts" CDS 1746214..1746612 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" /label="yndA CDS" gene 1746214..1746612 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /label="yndA gene" S_feature 1746613..1747417 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1746677..1747111) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" /label="flvS CDS" gene complement(1746677..1747111) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /label="flvS gene" downshifts complement(1746693) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1747141..1747160) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1747157) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1747174..1747181) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1747418..1747606 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" /label="ynzB CDS" gene 1747418..1747606 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /label="ynzB gene" S_feature 1747607..1747692 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1747651 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1747721..1747727 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1747739..1747898 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1747739 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1747741..1747752 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1747899..1749461 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" /label="yndD CDS" gene 1747899..1749461 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /label="yndD gene" promotor_-10 complement(1748202..1748221) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1748211) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1748236..1748243) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1749491..1750582 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" /label="yndE CDS" gene 1749491..1750582 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /label="yndE gene" CDS 1750572..1751786 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" /label="yndF CDS" gene 1750572..1751786 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /label="yndF gene" promotor_-35 1751864..1751871 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1751886..1751905 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1751897 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="upshifts" CDS 1751933..1752739 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" /label="yndG CDS" gene 1751933..1752739 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /label="yndG gene" S_feature complement(1752547..1753645) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1752744..1753361 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" /label="yndH CDS" gene 1752744..1753361 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /label="yndH gene" CDS 1753358..1754998 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" /label="yndJ CDS" gene 1753358..1754998 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /label="yndJ gene" promotor_-10 complement(1753632..1753651) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1753645) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1753665..1753673) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1754638..1755404) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1755035..1755400 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" /label="yndK CDS" gene 1755035..1755400 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /label="yndK gene" downshifts 1755377 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1755397..1755677) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surA RNA" gene complement(1755397..1755677) /gene="surA" /locus_tag="BSU_misc_RNA_72" /label="surA gene" S_feature complement(1755406..1755537) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1755449) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1755497..1755506 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1755519..1755528) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1755520..1755539 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1755525 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" S_feature 1755527..1755625 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1755537) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1755539..1755669) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1755626..1756384 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" /label="pghL CDS" gene 1755626..1756384 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /label="pghL gene" upshifts 1755659 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1755675..1755694) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1755676) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1755709..1755716) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1756199..1756410) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1756363 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" S_feature 1756408..1757027 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1756411..1756950) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" /label="yndM CDS" gene complement(1756411..1756950) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /label="yndM gene" promotor_-10 complement(1756951..1756965) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1756957) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1756979..1756985) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1757005..1757014 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1757027..1757042 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1757029 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" CDS 1757068..1757502 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" /label="fosB CDS" gene 1757068..1757502 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /label="fosB gene" CDS 1757360..1757707 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" /label="yzzP CDS" gene 1757360..1757707 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /label="yzzP gene" S_feature 1757503..1757835 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1757794..1757803 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1757815..1757830 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1757837..1758015 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1757837 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1757906..1757985 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="ncrF RNA" gene 1757906..1757985 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /label="ncrF gene" downshifts 1757972 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1758044..1758661) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" /label="lexA CDS" gene complement(1758044..1758661) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /label="lexA gene" downshifts complement(1758045) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1758685..1758704) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1758706) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1758718..1758725) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1758741..1758748 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1758760 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1758762..1758781 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1758811..1759128 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" /label="dinK CDS" gene 1758811..1759128 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /label="dinK gene" promotor_-10 complement(1758828..1758846) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1758831) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1758860..1758867) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1759147..1759800 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " /label="dinL CDS" gene 1759147..1759800 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /label="dinL gene" promotor_-35 1759803..1759810 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1759824..1759843 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1759837 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="upshifts" CDS 1759864..1760097 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" /label="ynzC CDS" gene 1759864..1760097 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /label="ynzC gene" S_feature 1760098..1760233 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1760201..1760208 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1760222..1760241 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1760235 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="upshifts" CDS 1760266..1762269 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" /label="tktA CDS" gene 1760266..1762269 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /label="tktA gene" misc_feature complement(1760470..1760489) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1760487) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1762259 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1762271..1762929) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1762369 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="upshifts" misc_feature 1762370..1762389 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1762422..1762868 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" /label="pcfA CDS" gene 1762422..1762868 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /label="pcfA gene" misc_feature 1762892..1762911 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1762900 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1762911..1762928) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1762929) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1762947..1762951) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1762954..1763172 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" /label="yneF CDS" gene 1762954..1763172 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /label="yneF gene" downshifts 1763184 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" /label="downshifts" S_feature 1763229..1763528 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1763246..1763419) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" /label="spo0D CDS" gene complement(1763246..1763419) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /label="spo0D gene" downshifts complement(1763259) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1763457..1763476) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1763464) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1763490..1763497) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1763499..1763507 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1763519..1763538) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1763519..1763537 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1763530..1763638 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1763530 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1763531) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1763553..1763560) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1763639..1764346 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" /label="ccdA CDS" gene 1763639..1764346 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /label="ccdA gene" promotor_-35 1764366..1764373 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1764385..1764404 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1764393 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1764435..1764797 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" /label="yneI CDS" gene 1764435..1764797 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /label="yneI gene" promotor_-35 1764815..1764818 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1764833..1764852 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1764844 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1764876..1765367 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" /label="yneJ CDS" gene 1764876..1765367 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /label="yneJ gene" downshifts 1765363 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1765398..1765826) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" /label="yneK CDS" gene complement(1765398..1765826) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /label="yneK gene" downshifts complement(1765415) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1765844..1765863) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1765856) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1765858..1765943) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1765877..1765884) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1765914..1765923 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1765933..1766042 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1765933 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1765936..1765955 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1765938..1765957) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1765943) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1765945..1766028) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1765972..1765975) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1765999 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1766060..1766452) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" /label="cotM CDS" gene complement(1766060..1766452) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /label="cotM gene" downshifts complement(1766073) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" /label="downshifts" promotor_-35 1766295..1766300 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1766316..1766334 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1766320 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="upshifts" promotor_-35 1766430..1766434 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1766444..1766458 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1766459..1766478) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1766461 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1766474) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1766492..1766501) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1766533..1766679) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" /label="sspP CDS" gene complement(1766533..1766679) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /label="sspP gene" downshifts complement(1766554) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1766711..1766857) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" /label="sspO CDS" gene complement(1766711..1766857) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /label="sspO gene" S_feature 1766857..1766990 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1766857 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1766868..1766870 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1766873..1766884) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1766887) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1766899..1766905) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1766980..1766987 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1766992..1767084 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1766992 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1767002..1767021 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1767043) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1767085..1769814 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" /label="citB CDS" gene 1767085..1769814 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /label="citB gene" misc_feature complement(1767105..1767109) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1767109) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1769815..1769885 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1769886..1770398 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" /label="yneN CDS" gene 1769886..1770398 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /label="yneN gene" downshifts 1770355 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-35 1770424..1770430 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1770443 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1770445..1770456 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1770479..1770604 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" /label="ynzL CDS" gene 1770479..1770604 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /label="ynzL gene" downshifts complement(1770497) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" /label="downshifts" promotor_-35 1770618..1770624 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1770639..1770650 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1770641 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" CDS 1770669..1770815 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" /label="sspN CDS" gene 1770669..1770815 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /label="sspN gene" CDS 1770852..1771103 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" /label="sspT CDS" gene 1770852..1771103 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /label="sspT gene" downshifts 1771081 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1771124..1771129 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1771143..1771162 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1771147..1771238 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1771147 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1771239..1771604 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" /label="yneP CDS" gene 1771239..1771604 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /label="yneP gene" CDS 1771620..1771919 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" /label="yneQ CDS" gene 1771620..1771919 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /label="yneQ gene" downshifts 1771895 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1771950..1772237) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" /label="yneR CDS" gene complement(1771950..1772237) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /label="yneR gene" downshifts complement(1771971) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(1772037) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1772267..1772286) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1772279) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1772302..1772309) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1772325..1772906) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" /label="plsY CDS" gene complement(1772325..1772906) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /label="plsY gene" S_feature 1772907..1773037 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1772932..1772951) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1772949) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1773022..1773025 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1773039 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1773041..1773060 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1773076..1773483 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" /label="yneT CDS" gene 1773076..1773483 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /label="yneT gene" downshifts 1773479 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" /label="downshifts" promotor_-35 1773545..1773548 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1773563..1773582 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1773567..1773881 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1773567 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" CDS 1773882..1775849 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" /label="parE CDS" gene 1773882..1775849 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /label="parE gene" CDS 1775853..1778273 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" /label="parC CDS" gene 1775853..1778273 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /label="parC gene" downshifts 1778253 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1778281..1778470) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1778320..1778496) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" /label="ynfCc CDS" gene complement(1778320..1778496) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo /label="ynfCc gene" downshifts complement(1778324) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1778471..1778881) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" /label="ynfCn CDS" gene complement(1778471..1778881) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo /label="ynfCn gene" promotor_-10 complement(1778854..1778873) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1778857) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1778888..1778895) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1778922..1778941) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1778923) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1778956..1778963) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1778970..1778989) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1778981) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1779003..1779012) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1779229..1779234 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1779247..1779266 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1779252 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="upshifts" S_feature 1779265..1779329 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1779330..1780727 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" /label="alsT CDS" gene 1779330..1780727 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /label="alsT gene" downshifts 1780716 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 1780761 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(1780817..1781563) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1780940..1780947 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1780959 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1780960..1780979 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1781030..1782529 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" /label="eglS CDS" gene 1781030..1782529 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /label="eglS gene" promotor_-10 complement(1781562..1781581) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1781585) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1781595..1781604) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1782477 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1782597..1782860 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" /label="ynfE CDS" gene 1782597..1782860 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /label="ynfE gene" downshifts complement(1783119) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1783119..1784387) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" /label="xynC CDS" gene complement(1783119..1784387) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /label="xynC gene" S_feature complement(1784388..1784517) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1784518..1786059) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" /label="xynD CDS" gene complement(1784518..1786059) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /label="xynD gene" S_feature complement(1786060..1786381) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1786371..1786390) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1786382) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1786405..1786408) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1786608..1786615 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1786628..1786647 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1786635 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1786654..1787100 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" /label="yngA CDS" gene 1786654..1787100 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /label="yngA gene" CDS 1787107..1788000 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" /label="yngB CDS" gene 1787107..1788000 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /label="yngB gene" misc_feature 1787617..1787636 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1787625 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="upshifts" CDS 1788073..1788669 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" /label="yngC CDS" gene 1788073..1788669 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /label="yngC gene" downshifts 1788659 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1788718..1789917) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" /label="nrnB CDS" gene complement(1788718..1789917) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /label="nrnB gene" S_feature complement(1789918..1789989) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1789977..1789988) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1789989) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1790003..1790009) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1790087..1791622) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" /label="ldeE CDS" gene complement(1790087..1791622) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /label="ldeE gene" downshifts complement(1790099) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1791633..1792415) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" /label="ldeF CDS" gene complement(1791633..1792415) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /label="ldeF gene" CDS complement(1792436..1793335) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" /label="ldeG CDS" gene complement(1792436..1793335) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /label="ldeG gene" CDS complement(1793350..1793571) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" /label="lgeHB CDS" gene complement(1793350..1793571) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /label="lgeHB gene" CDS complement(1793586..1794920) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" /label="ldeHA CDS" gene complement(1793586..1794920) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /label="ldeHA gene" CDS complement(1794930..1796579) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" /label="ldeI CDS" gene complement(1794930..1796579) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /label="ldeI gene" promotor_no_box 1794979..1795079 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1795039 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1796623..1797765) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" /label="ldeJ CDS" gene complement(1796623..1797765) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /label="ldeJ gene" promotor_-10 complement(1797784..1797802) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1797801) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1797818..1797823) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1797856..1798161) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " /label="ynzE CDS" gene complement(1797856..1798161) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /label="ynzE gene" CDS complement(1798151..1798324) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" /label="conserved protein of unknown function CDS" gene complement(1798151..1798324) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /label="gene" CDS complement(1798432..1799964) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" /label="yngK CDS" gene complement(1798432..1799964) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /label="yngK gene" downshifts complement(1798443) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1799999..1800018) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1799999) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1800031..1800040) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1800100..1800492) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" /label="yngL CDS" gene complement(1800100..1800492) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /label="yngL gene" downshifts complement(1800131) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1800520..1800531) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1800527) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1800545..1800551) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1800603..1804442) /gene="ppsE" /locus_tag="BSU_18300" /old_locus_tag="BSU18300" /EC_number="2.3.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 12486459, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 12486459, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase E" /protein_id="NP_389712.1" /db_xref="EnsemblGenomes-Gn:BSU18300" /db_xref="EnsemblGenomes-Tr:CAB13713" /db_xref="GOA:O31827" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11962" /db_xref="UniProtKB/Swiss-Prot:O31827" /translation="MKKGADTMNTIKKIKNIYPLSHMQEGMLFHSFLRKEEGAYVEQS LFTIKGSLSYDWFQRSIQAIIDRHDIFRTVFLPHVPHLSGPRQVVMTEREFHLNSEDI SHLPTNDQNEYIERFKEKDKQKGFDLQKDMLMRISLFKTAKDEHVCIWSHHHILMDGW CLGIVMQEFMQIYQSIHAGKPLSLDPVRPYSTYISWLTNRDKEKAAAYWDTYLKNYSA PSPLPRVSDKETKESYHREDLIFSLNKPLTDKLKETAKQHGVTLATLIQAVWGVMLQQ YNRTDDVVFGAVVSGRPSEIPGVEQMIGLFINTIPIRIKTHQDETFHELLIRCQKEML EAEPFTCQPLFDIQANTALKQELIDHIIVFENYPLQQKIADSADQTDSPLQIDQVQVS EQSGYNFNLVVAPGEELVIKFSYNAFVYDAAWISCIKRQFTQALSTAAQHPHMPIADF SFLDATEKEQIVTQFNNTKTEYPKNHTIIDLFREQAEKTPDHTALVYGNMSISYKELD KRSNALARELIQKGFRKNETAGILAAHSPEFMISVLAVLKAGGAYLPLDAELPPERVS FMLEETQAKMLIVQKGLEQNAAFSGTCIISDAQGLMEENDIPINISSSPDDLAYIMYT SGSTGRPKGVMITNRNVVSLVRNSNYTSASGDDRFIMTGSISFDAVTFEMFGALLNGA SLHIIDKSTMLTPDRFGAYLLENDITVLFLTTALFNQLAQVRADMFRGLHTLYVGGEA LSPALMNAVRHACPDLALHNIYGPTENTTFSTFFEMKRDYAGPIPIGKPISNSTAYIL DTKGRLLPIGVPGELCVGGDGVAKGYLNRVDLTNAVFSPHPFLPGERIYRTGDLARWL PDGNLEYISRIDRQMKIRGKRIEPAEIEARLLEMEGVQEAAVTLREKDGEAQLYTHYV GDHKKTDTDFRADLARVLPDYMIPQHWVRVERMPLTGNGKIDRSALPIPENKPAKRQN IILPRNLVEEELANIWKQVLGVNTISIDDDFFAIGGHSLRALQVIHTLKHQQNIDIPI DFLFEHPTIAQLAEKLYSKQLTAANEQHVIKLNQHGAQNLFCFPPISGFGIYFKDLAL LLNEKAAVYGFHFIEQDTRIEQYVNCMTDIQPEGPYVLLGYSAGGNLAFEVAQAMERK GLEVSDFIIVDAYLKEQPLPIDTGNDESAAYLPEAVREKVMKKKRNYQEYWAQLLNEG HIKASIHFIEAGIHPETSGHTGLTKWEGACGNYSEYTGFGAHKDMLEGTYAEKNADII LDILEKITSNQVILHKR*" /label="ppsE CDS" gene complement(1800603..1804442) /gene="ppsE" /locus_tag="BSU_18300" /old_locus_tag="BSU18300" /label="ppsE gene" downshifts complement(1800615) /Source="Nicolas_upshifts" /id="D1001" /incds=0 /nref=51 /ntot=190 /MaxReadThrough="0.85603" /MaxDrop="4.50208" /score="20.3407616" /energy="-16.7" /TU="NA" /idTUdmin="U1479" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS complement(1804450..1815261) /gene="ppsD" /locus_tag="BSU_18310" /old_locus_tag="BSU18310" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase D involved in synthesis of plipastatin" /protein_id="NP_389713.2" /db_xref="EnsemblGenomes-Gn:BSU18310" /db_xref="EnsemblGenomes-Tr:CAB13714" /db_xref="GOA:P94459" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11961" /db_xref="UniProtKB/Swiss-Prot:P94459" /translation="MTKANSIQDIYPLSYMQEGMLFHSLLQKDSQAYVEQASFTIEGK VNPQFFQNSINALVERHDIFRTIFISQNVSSPQQVVLRERNVIVLEEDITHLNEAEQS QFIEQWKEKDRDRGFHLQKDVLMRIALIQTGESQYSCIWTFHHIMMDGWCLSIVLKEF LHIYASYVNASPITLEPVQPYGKYIKWLMEQDKEQAVSYWDHYLSGHEQQTVLPKQKK TKGKSRQEHVTFSFSKEESSRLSELAAREEVTLSTIFHTIWGILLQKYNNNDDAVFGS VISGRPAEIEGIEHMVGLFINTMPVRVQGAKTPFLQLIKDMQKDRLAAEAYSYHPLYE IQSRSAVKQGLIDHILVFENYPVQQEIQMLNKQEHASDLFQIHNFTVADETNYSFYLM VAPGEEIHIKMNYDAEQHDRSFVLSVKEHLLNAVSQILNNPNLPPEEIDITTDTEKRQ LIGEITDQTPVYETIHAMFEKQAEKTPDAHAVIDQACSLTYRELNKAANRLARHLRMK GVVRQEPVAIMMERSAAFITGVLGILKAGGAIVPVDPHYPADRIRYILHDCGCSHVVS QAHLPSSLEDNYIITHPEDIESKVDGSNIKSVNNADDLLYMIYTSGTTGKPKGVQFEH RNMANLLKFEYTHSGIDFEADVLQFATPSFDVCYQEIFSALLKGGTLHIVPEAIKRDV PQLFAFINKHQTNIVFLPTAFIKMIFSERELANSFPDGVKHLIAAGEQLMISDLFQDV LRKRGIHLHNHYGPSETHVVSTYTIHPGDPIPELPPIGKPIGCTDLYILNHQKQLQPC GVPGELYISGASVARGYVNHDKLTSDKFSSDPFKPDVIMYRTGDLARRLEDGNIEYIG RADNQVKIRGYRIEPQEIEVTLMNHPDISEAAILIWQDQNGEHELCAYYCSVQKLNTI DLRSYMASELPEYMIPAKWIWVDSIPLTPNGKVDRAALPEPDASISGNPYTAPRNLLE AKLSQLFEDVLKNGHIGIQDNFFDNGGHSLKATVLMSRIAKEFHVQVSLKDIFAHPTV EGLALIIREAEQNLYAAIEPAEKRDTYPVSSAQKRIYVLQQLDEGVAYNMPAVLELEG ALDVAKLSAVCKELISRHEPLRTSFVSGADDEPVQRIHTEVPFTLSKETTIEGFVRPF DLSQAPLFRAGLIEVSNEKHVLLVDMHHIISDGVSVQLLIREFTDLYANRQLKPLRIQ YKDYAVWQQKFKKGDSYQKQETYWQQQFSGDLPILELPTDKRRPAERQFIGGKVTFQL DKEITARIKRLAHKNRSTLYMTLLALYSAFLSRLSGQDDIVIGSPIAGRPHADLEAVL GMFVNTLALRTRPAGNKTFEEFLKEVRQTALEAYEHQDYPFEELVDKLGVQREMSRNP LFDTTLVLQNMEQQKLKMNDVQLQWNDLEHPISKFDISLYVTEHDSELFCQFEYSTAL FEKETIQRWASLFTTLVEHTAASPETELDNIPILTKEEERDFIESCHLFEETGYSMNQ TLHYALEQQAEKTPDQAAVIFEDGVMTYKELNEQANRIAWELIGRGVKPETTVAIIGK RSPEMLLGIYGILKAGGAYLPIDPDYPEERISFLLEDSGTNILLLQSAGLHVPEFTGE IVYLNQTNSGLAHRLSNPNVDVLPQSLAYVIYTSGSTGMPKGVEIEHRSAVNFLNSLQ SRYQLKHSDMIMHKTSYSFDASIWELFWWPYAGASVYLLPQGGEKEPEVIAKAIEEQK ITAMHFVPSMLHAFLEHIKYRSVPIKTNRLKRVFSGGEQLGTHLVSRFYELLPNVSIT NSYGPTEATVEAAFFDCPPHEKLERIPIGKPVHHVRLYLLNQNQRMLPVGCIGELYIA GAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGRTDDQVKIR GYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQLERLLPGY MVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQLWEDVLKN GPVGIHDNFFDRGGHSLKATALVSRITKEFDVQVPLKDVFAHPTVEGLATVIREGTDS PYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNPERMDRAFQ ELIKRHESLRTSFEQDEGGDPVQRIHDEVPFTLQTTVLGARTEQEAAAAFIKPFDLSQ APLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIQEFGELYNNRKLPALRIQYKDY AVWQEGFKTGDAYKMQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKVSFTLEPEV ASGLHKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDLEPILGMFV NTLALRTRPEGGKPFVQYLQEVRETALEAFEHQNYPFEELVDKLELTRDMSRNPVFDA MLVVQNNDYEPLHLHDLQMKPAQVSHLVSKFDLTLQASEGDGNIHFLFEYSTALFEKT TIERWASHLTNVLSIIGKNPKVTLNHIDILTQEERHQLLNEFNTGQANQYGVQTISQL FEQQAARTPKASALVSGDKTLTYQELDEWSNGIARALRSRGVKPDTPVGIMMHRSFSM IASILGVWKAGGCYVPIDPEYPKERKRYILSDSGTKLLMTINEADLGVLADFEGEILT IESVEEDDKSPLPQMSSAHHLAYIIYTSGTTGRPKGVMVEHKGIANTLQWRRNAYAFN ETDTILQLFSFSFDGFITSMFTPLLSGAKAVLLHEEEAKDILAIKHQLSRQRITHMII VPVLYRALLDVVQPEDVKTLRVVTLAGEAADRELIARSLAICPHTELANEYGPTENSV ATTVMRHMEKQAYVSIGQPIDGTQVLILNSNHQLQPIGVAGELCIAGTGLARGYVNLP ELTERAFTQNPFKPEARMYRTGDAARWMADGTLEYLGRIDDQVKIRGYRVETKEIESV IRCIKGVKDAAVVAHVTASGQTELSAYVVTKPGLSTNAVRSELQNKLPVFMHPAFIEK LDSLPLSPNGKLDRGALPKPVYNHEGERPFLPPSSKMEQILADIWKEVLGAEKIGTAD SFFELGGDSIKALQVSARLHRIGKQMAVKDLFSHPTIQELAAYIRDSDTSSSQAAVEG DVQWSPVQKWFLSQDIKEKHHFNQSVMLHRSTSVQEDALRKTLKAITCHHDALRMVFT QNEQGKWDQYNRPLSHSDDALYGLQMIDLSAPDGTDGNRPYEPLIKRHVLDIQQKMDL KNGPLLQAGLFHTIDGDFLFLSAHHLVVDGISWRVLLEDLALGYRQAAGGEDIKLPPK TSSFKAYAKKLSDYAESQQLMKQLKYWREAEEYQTEALPFDQIDGTRAHEGQRSTISF TLNDKETAALLKDANSAYNTDTQDMLLASVILALRHWTNQSAFKLSLEGHGREDVLKG IDVSRTIGWFTAIYPLLIKLNADLPDSEESMVHVLKTTKDTLRRVPDKGFGYGVIKYL TPPGKKDINFTGAPEISFNYLGQFESGRTAEVPEEDAFSFSPLGAGGDISTTWNREQS LDISAIAAEGKLTVNMTYDNARFQRKTIEQLSETCRQFLLQLIEHCQNKSETEKTISD FDDQELTEDALQEIADMLSFH*" /label="ppsD CDS" gene complement(1804450..1815261) /gene="ppsD" /locus_tag="BSU_18310" /old_locus_tag="BSU18310" /label="ppsD gene" promotor_-35 1807470..1807473 /Source="Nicolas_upshift_promotors" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1807490..1807509 /Source="Nicolas_upshift_promotors" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1807491 /Source="Nicolas_upshifts" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1815286..1822953) /gene="ppsC" /locus_tag="BSU_18320" /old_locus_tag="BSU18320" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non-ribosomal plipastatin synthetase C involved in synthesis of plipastatin" /protein_id="NP_389714.1" /db_xref="EnsemblGenomes-Gn:BSU18320" /db_xref="EnsemblGenomes-Tr:CAB13715" /db_xref="GOA:P39847" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10972" /db_xref="UniProtKB/Swiss-Prot:P39847" /translation="MPQQPEIQDIYPLSFMQEGMLFHSLYDEQSRAYFEQASFTIHGQ LDLERFQKSMDAVFDRYDIFRTAFIYKNVAKPRQVVLKQRHCPIHIEDISHLNERDKE HCTEAFKEQDKSKGFDLQTDVLMRISILKWAPDHYVCIWSHHHILMDGWCLGIVIKDF LHIYQALGKGQLPDLPPVQPYGTYIKWLMQQDREEAAEYWKKRLQHFEKSTPLPKRTD QIPNGTLQQITFAIPEKETAELQKIAAASGATLNTVFQALWGIMLQKVNRSSDAVFGS VISGRPSELKDVENMVGLFINTIPIRAQSDSLSFSDLVRRMQKDMNEAEAYSYFPLYD IQAQSALKQELIDHIIVFENTPTQQEIEELNQAGSFDFSVKDFEMEEVTNYSCSVKVI PGRTLYVRIHFQTSAYQPSMMSEIKDYLLHMVSDVISDPSLPVSKMTLLDEDKTRKIV SQNNRTVSVSPEAPTLHGLFERQAAVTPERLAIRFSGGSLTYAELDMYASRLAAHLAA RGVTNESIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLL TQPGCSAPNFSGETLEVDMTSLECEEVKRHVSASVSDGSLAYVIYTSGSTGQPKGVAV EHRQAVSFLTGMQHQFRLSEDDIVMVKTSFSFDASVWQLFWWALSGASAYLLPPGWEK DSALIVQAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAA RFASVLPQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHL AVQPSGVAGELYIAGAGVARGYLNRPALTEERFLEDPFYLGERMYKTGDVARWLPDGN VEFLGRTDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQR NEVRAQLQRLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVT EMKLSQLWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPT VEGLATVIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLEL EGKLNLERMDRAFKELIKRHESLRTAFEQDAGGDPVQRIHDEVPFTLQTTVLGARTEE EAAAAFIKPFDLSQAPLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIREFGELYN NRKLPALRIQYKDYAVWQEGFKTGDAYKTQGAYWLKQLEGELPVLDLPADHARPPMRS FAGDKVSFTLDQEVTSGLYKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAG RPHKDLEPILGMFVNTLALRTRPEGGKPFVQYLQEVRETAMEAFEHQDYPFEELVDKL ELTRDMSRNPLFDVMFVLQNMDQESLELDELCLKPAANNGHQTSKFDLTLYAQEQPRG LLTFQMEFSTDLYKKKTIEKWLQYFNNMLLSIIKDNKAALGTINILNEDEAHYLIHEL NRTKIDYPRNETISRLFEMQAEQTPNAVAIVSDTQVFTYEDLNSWANQIASVLQIKGV GPDSVVALLTGRTPELIAGMLGILKAGGAYLPIDSNLPVERIAYMLSDSRAALLLQSE KTEKRLLGIECEQIIIEDIQKQGEAKNVESSAGPHSLAYIIYTSGSTGKPKGVMIEQR SVIRLVKNSNYITFTPEDRLLMTSSIGFDVGSFEIFGPLLNGAALHLSDQQTFLDSHQ LKRYIEHQGITTIWLTSSLFNHLTEQNEQTFSQLKHLIIGGEALSPSHVNRIRNVCPE VSIWNGYGPTENTTFSTCLHIQKTYELSIPIGRPVGNSTAFILNQWGVLQPVGAVGEL CVGGDGVARGYLGRPDLTKEKFVPHPFAPGDRLYRTGDLARWLSDGTIEYVGRIDDQV KVRGYRVELGEIETALRQIDGVKEAAVLARTAQTGSKELFGYISVKAGTNAEQVRSLL ARSLPNYMIPAYIIEMETLPLTSNGKLNRKALPEPDVASKQTYIPPRNELEEQLALIW QEVLGIQRIGIEDSFFELGGDSIKALQVSARLGRYGLSLQVSDLFRHPKIKDLSPFIR KSERIIEQGPIQGDVPWTPVQQWFFSQDIEERHHFNQSVMLFHSGRLSENALRPALKK LAEHHDALRMVYRNDDRRWIQINQGIHESQLYSLRISDLSQSESGWETKIKQEVADLQ QSINLQEGPLLHAALFKTLTGDYLFLAIHHLVVDGVSWRILLEDLSAGYQQAAAGQTI QLPPKTDSYQEYARRIQEYAQSSKLIREEAYWRSVEEQQAAELPYEIPHHVNIDFSKR DSLSFSLTEADTAVLLQNVNHAYGTDTQDILLTAASLAICEWTGGSKLRIAMEGHGRE HILPELDISRTVGWFTSMYPALISFENHRDELGTSVKTVKDTLGRIPNKGVGYGMLKY LTHPENKSITFSKTPEISFNYLGQFNDIERQDTFRPSSLGSGKDITHTWKREQIIEMS AMAADKKLHFNLSYPPARFHRNTMEQLINRIEHFLLDIMKHCAGQQKAEKTLSDFSSQ SLTAEDLDSISSLVEEL*" /label="ppsC CDS" gene complement(1815286..1822953) /gene="ppsC" /locus_tag="BSU_18320" /old_locus_tag="BSU18320" /label="ppsC gene" CDS complement(1822970..1830652) /gene="ppsB" /locus_tag="BSU_18330" /old_locus_tag="BSU18330" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase B involved in synthesis of plipastatin" /protein_id="NP_389715.1" /db_xref="EnsemblGenomes-Gn:BSU18330" /db_xref="EnsemblGenomes-Tr:CAB13716" /db_xref="GOA:P39846" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10971" /db_xref="UniProtKB/Swiss-Prot:P39846" /translation="MAQSAQIQDIYPLSHMQEGMLFHSLMDFSSKAYIEQTSFTITGN LCVDSFQKSLNLLVSRYDIFRTIFIKEVPDLTGPQQVVLSNRELTVYREDISRLADQE QQTLIDAFMTKDREKGFDLQKDPLMRLALFDRGDSQYTCVWTHHHIIMDGWCLGIILK EFFSMYDSLKNNSPVQLGSTVPYSRYIEWLGEQDQEETAAYWSEYLKEYGNTASIPRI KRRTADGNYKADQVSFSLAPDMVEKLTEAAQNWGVTLNTLFMSIWGVLLHRYNAADDA VFGSVISGRPSAIDGIESMVGLFINTVPVRIRSAEGITFSSLVKAVQEDILSSEQHGY YPLYEIQNHSPLKQGLIDHIFVFENYPVQLHQALSVESENDEGALKLSDISMSEQTNY DFNIVIVPGESFYIKFSYNADVYEREEMLRIQGHLKQALDCILTNPDVAVSDINIVPP EEQQVIQLFNETERPYVNKTIPQLFEEQAHKTPEAAALKMGNECWTYRQLQVRANQIA HALIEKGVGSGDIVAVMMGRSMEMPAALLGIWKAGGAYMPLDPHFPAERLSFLLKDSQ AAQLLIEEDLISLIPPSYEGNTITIEHTESYQTEAPNMPPGDLAYLIYTSGTTGRPKG VLVDHHGIANTLQWRREEYSMTEQDISLHLFSYVFDGCVTSLFTPLLSGACVLLTTDD EAKDVLALKRKIARYKVSHMIIVPSLYRVLLEVMTADDAKSLRIVTFAGEAVTPDLLE LNQIICPSAELANEYGPTENSVATTILRHLNKKERITIGHPIRNTKVFVLHGNQMQPI GAAGELCISGAGLARGYYKQQELTQKAFSDHPFLEGERLYRTGDAGRFLPDGTIEYIG RFDDQVKIRGYRIELREIETVLRQAPGVKEAAVLARDVSAEEKELVAYIVPEKGNSLP DLYQHLAGTLPSYMIPASIINISQMPLTSSGKLDRFALPEPENNTSVTYMAPRTLIEA DLAHIWEDVLNKQHIGIRDDFFQLGGQSLKAAALVSRIHKKLNVELPLSEVFSYPTVE SMAVKLMSLKEHAFTQIEPADQRDVYPLSFSQKRLYALHQLADDSTGYNMPAVLELRG NLNRQRLRSVLTELVNRHEALRTVFVLDRDEPVQIIYPEMAFDLKELEMESEQMLESA IETFIKPFYLSSGPLFRACVITMGNNRGFLLLDMHHIIADGVSMSTLVQEFTDLYCGK ELPALNLHYKDFAVWQQEKHPKELYKKQEAYWLGQLGGSLPTLELPLDKTRPRLPDFR GGTIEVNIDKDMADELHRLMAETGTTLYMILLAVYSILLSKLSGQEDIVVGSPAAGRP HADLERVIGMFVNTLAMRSKPEGHKTFSSYLHDIRHLALTAYEHQDYPFEELADKLDT NREVNRNPLFDAMLVLQSSEDFRFEVPGLSISSVTPKHDISKFDLTLHAEEHLSGIRC RFEYSTALFEEETITQWASYFIELVKGVTADTEMRISNMQLLPAAERRLLLEKMGQYA AYPRNENIVSLFEKQVAQYPEHIAVVCGHSQLTYRDLNEKAERAAAMLIKQGVRTGDI VGLMLDRSPDMIIGVLSILKAGGAYLPIDPEYPKERISFMLNDSGAKLLLTERGLNKP ADYTGHILYIDECENNSIPADVNIEEIVTDQPAYVIYTSGTTGQPKGVIVEHRNVISL LKHQNLPFEFNHEDVWTLFHSYCFDFSVWEMFGALLNGSTLVVVSKETARDPQAFRLL LKKERVTVLNQTPTAFYGLMLEDQNHTDHLNIRYVIFGGEALQPGLLQSWNEKYPHTD LINMYGITETTVHVTFKKLSAADIAKNKSNIGRPLSTLQAHVMDAHMNLQPTGVPGEL YIGGEGVARGYLNRDELTADRFVSNPYLPGDRLYRTGDLAKRLSNGELEYLGRIDEQV KVRGHRIELGEIQAALLQYPMIKEAAVITRADEQGQTAIYAYMVIKDQQAANISDIRT YLKNALPDFMLPARMIQIDSIPVTVNGKLDQKALPEPEKQAYTADDISPRNEIETVMA EIWEELLNVDELGVSANFFKLGGDSIKALQVCARLKQRGFETTVREMFEHQTLGELSA RVRKDVRAIDQGPVEGEITWTPIQQWFFSQSLESHHFNQSVMIYRAERFDEAALRKVL KSLVTHHDALRIVCRHEDGRQVQINRGIDLSDEELYALELFDVKDSLTEARNTIEEAA SRMQEHIRLETGPLLHAGLFRTENGDHLFLTIHHLVVDAVSWRILFEDFSTAYKQAVS GESIKLPQKTDSYLTYSQRIADYSISRQVQREAAYWDECENRHIQPIPKDNDAASNTF KDTEVIDFELSRHHTELLLTAAHKAYSTEMNDILLTALGLALQKWTGNNQFKISMEGH GRESYLEDIDISRTVGWFTSIYPVWLDMRDSDHKDKEERLGHLIKQTKDMLHRIPHKG AGYGVLKYISKRWGSQKNSPEISFNYLGQFDQDIQSNAFEVSDIKPGNEISPNWERPY ALDISGAVSSGCLNMHIIYNRFQFEEKTIQTFSRHFKQTLENIIEHCTGKENQEWSAS DFTDEDLTLDELSEIMGAVNKL*" /label="ppsB CDS" gene complement(1822970..1830652) /gene="ppsB" /locus_tag="BSU_18330" /old_locus_tag="BSU18330" /label="ppsB gene" downshifts complement(1826641) /Source="Nicolas_upshifts" /id="D1002" /incds=1 /nref=2 /ntot=18 /MaxReadThrough="4.83331" /MaxDrop="4.93461" /score="20.5621533" /energy="-10.2" /TU="U1481,U1483" /idTUdmin="U1481" /TUdmin="-5742" /isTUend="FALSE" /label="downshifts" upshifts complement(1826685) /Source="Nicolas_upshifts" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1826687..1826691) /Source="Nicolas_upshift_promotors" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1826709..1826712) /Source="Nicolas_upshift_promotors" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1826988..1826992 /Source="Nicolas_upshift_promotors" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1827005 /Source="Nicolas_upshifts" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1827008..1827027 /Source="Nicolas_upshift_promotors" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1830677..1838362) /gene="ppsA" /locus_tag="BSU_18340" /old_locus_tag="BSU18340" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 14762003, 16707694, 26284661, 26268540" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 14762003, 16707694, 26284661, 26268540; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="non-ribosomal plipastatin synthetase A involved in synthesis of plipastatin" /protein_id="NP_389716.2" /db_xref="EnsemblGenomes-Gn:BSU18340" /db_xref="EnsemblGenomes-Tr:CAB13717" /db_xref="GOA:P39845" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10970" /db_xref="UniProtKB/Swiss-Prot:P39845" /translation="MSEHTYSLTHAQRRVWFTELLEPDTSICNLTACVKFKGNIELDT LEGALNHSISRNDAIRFQLLEGEELEPRLHLTEYKYYPLRIIDFSNVEMIEIEQWIQD QASIPFKLFNSPLFQFYLLRIDSHEVWLFAKFHHIIMDGISLNVMGNQIIDLYQKMKK KDPLPDQPEPSYLSYIEKESQYLQSPRFAKDRLFWTQTFEHPLEYHSLADQTSLQKQS TSASRDTIILSPDLEQTIRIFCEEHKINIISLFMASFYICISRITSKKDLAIGTYYGN RGSKAEKEMLGMFVSSLPIRITVDPDTDFLSFVRTIGREQLSVMRHQRFPYNLLVNEL RNEQKDLHNLIGISMQYQPLQWHNADDFDYETALYFSGYTANELSVQIQERIDNGTIQ LNFDYQNTLFSLEDIKRIQSHLLTILENALKHPHSFIRELDMTNTREKQKLLYEFNKT EAVSPKAFTLHGLFERQAAFTPERLAIRFSGGSLTYAELDMYASRLAAHLAARGVTNE SIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQPGCS APNFSGETLEVDMTSLASEKAENHEFTPADGGSLAYVIYTSGSTGQPKGVAVEHRQAV SFLTGMQHQFPLSEDDIVMVKTSFSFDASVWQLFWWSLSGASAYLLPPGWEKDSALIV QAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAARFASVL PQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHLAVQPSG VAGELYIAGAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGR TDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQ LERLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQ LWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPTVEGLAT VIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNP ERMERAFKELIKRHESLRTSFEQDAGGDPVQRIHDEVPFTLQTTVLGERTEQEAAAAF IKPFDLSQAPLFRAQIVKISDERHLLLVDMHHIISDGVSVNILIREFGELYNNRNLPA LRIQYKDYAVWREGFKTGDAYKTQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKV SFTLDQEVASGLHKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDL EPILGMFVNTLALRTRPEGGKPFVQYLQEVRETALEAFEHQDYPFEELVDKLELTRDM SRNPVFDAMFILQNVEKQDIDLREIKVRPANFAHHISLFDITLIATEISGSICCEMEF STEVFLKATIERWADHFIEFLHEALSTPETSLAQINILSDKEKQKIVFEFNKTQVEFA QKDIPFHRIFEAKAEENPEHIAVIDNETEISYRLLNERANRLARTLQNRKGPKPTVAV LAKRSIDAIVGVLAVMKAGGVYIPIDAHYPKARIEYILRDSGADILLLQRELKHLISN SPESEMSHIFLDDEGSFEESNCNLNLSPAPEEPVYIIYTSGTTGAPKGVIVTYQNFTH AALAWRQIYELDRKPVRLLQIASFSFDVFSGDLARTLTNGGTLIVCPDETRLEPAEIY KIIKSQRITVMESTPALIIPVMEYVYRNQFKLPDLDILILGSDMVKAQDFKTLTDRFG QSMRIINSYGVTEATIDSSFYETSMGGECTGDNVPIGSPLPNVHMYVLSQTDQIQPIG VAGELCIGGAGVAKGYHHKPDLTQMKFTENPFVSGERLYRTGDRACWLPNGTIRLLGR MDYQVKINGYRIETEEIESVLLQTGLVREAAVAVQHDKNGQAGLAAYIVPSDVNTNAL RAALTKELPAYMIPAYLIPLVNMPLTLNGKLDRNALPAPNNVLSRPYTAPVNDLQKTM AYIWEDVLSMSRVGIHDSFFELGGDSIKALQVAARLAAEGWSMTIRDLFRYSTIQELC GHITPLASQADQGPAEGEAELTPIQRRFFGQVHAFHYHYNQSVMLFSEKGFNANALHL ALRKITEHHDAIRMIFQRDQNGHVIQFNRGINHKDHELFGLYISDWTKASLERAHLDE KLAAEETVIQSKMNVEKGPLLQAGLFKTAEGDHLLIALHHLVIDGVSWRILLEDLAAA YQQALEKKEIQLPPKTDSYLSYADGLTQIAESKQLLSEKTYWQTILDAHTAFLPKDIE NVPDKLQMNSDAAAFVLSGDWTEKLLFETQQAYGTDANELLLTALGMALSEWTGHDQI VISTEGHGREGHVPNIDISRTVGWFTSIYPILLDMGIPEPFEDQLAYRIKTTKDMLRR VPNKGTGYGLLTHIGELRHKEPEVSFNYLGQFSEEKEVETFQLSYYQPRYEIAGERER EYELDINALITDGRLHVKAVYTQVFSKHSIECFMDRFHRHLIETIEHCSQKKAREKTL SDFSNKELTLSALSSIEDLVKDL*" /label="ppsA CDS" gene complement(1830677..1838362) /gene="ppsA" /locus_tag="BSU_18340" /old_locus_tag="BSU18340" /label="ppsA gene" S_feature complement(1838363..1838471) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1838456..1838475) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1838471) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1838489..1838496) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1838745..1840220) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" /label="dacC CDS" gene complement(1838745..1840220) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /label="dacC gene" downshifts complement(1838757) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(1840254..1841231) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" /label="galM CDS" gene complement(1840254..1841231) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /label="galM gene" promotor_-10 complement(1841260..1841278) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1841272) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1841290..1841298) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1841365..1842756) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" /label="yoeA CDS" gene complement(1841365..1842756) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /label="yoeA gene" downshifts complement(1841379) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" /label="downshifts" downshifts 1841525 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" promotor_-35 1842546..1842552 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1842566..1842584 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1842577..1842910 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1842577 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="upshifts" S_feature complement(1842757..1842861) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1842821..1842921) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1842861) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1842883..1842888 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1842904..1842922 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1842912 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1842970..1842977 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1842990..1843009 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1842993 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" CDS 1843042..1843587 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" /label="iseA CDS" gene 1843042..1843587 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /label="iseA gene" downshifts 1843571 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA complement(1843681..1843753) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg1 tRNA" gene complement(1843681..1843753) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /label="trnSL-Arg1 gene" downshifts complement(1843779) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1843806..1844351) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" /label="yoeC CDS" gene complement(1843806..1844351) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /label="yoeC gene" promotor_-10 complement(1844391..1844410) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1844405) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1844424..1844431) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1844667..1844897) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" /label="yoeD CDS" gene complement(1844667..1844897) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /label="yoeD gene" downshifts complement(1844681) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1844923..1844942) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1844935) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1844954..1844960) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1844989..1845008) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1844999) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1845012..1845019 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1845033..1845052 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1845037 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="upshifts" CDS 1845082..1846845 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" /label="ggt CDS" gene 1845082..1846845 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /label="ggt gene" downshifts 1846826 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1846946..1847803) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" /label="ftsR CDS" gene complement(1846946..1847803) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /label="ftsR gene" promotor_-10 complement(1847849..1847868) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1847869) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1847882..1847889) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1847931..1848920 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" /label="yogA CDS" gene 1847931..1848920 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /label="yogA gene" S_feature complement(1847987..1848945) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1848977..1850458) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" /label="gltB CDS" gene complement(1848977..1850458) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /label="gltB gene" downshifts complement(1848990) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" /label="downshifts" CDS complement(1850475..1855037) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" /label="gltA CDS" gene complement(1850475..1855037) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /label="gltA gene" promotor_no_box 1853498..1853598 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1853558 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1855038..1855109) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1855089..1855108) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1855106..1855113 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1855109) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1855123..1855130) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1855125 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1855128..1855147 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1855184..1856086 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" /label="gltC CDS" gene 1855184..1856086 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /label="gltC gene" downshifts 1856066 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1856138..1857253) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" /label="proJ CDS" gene complement(1856138..1857253) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /label="proJ gene" CDS complement(1857250..1858143) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" /label="proH CDS" gene complement(1857250..1858143) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /label="proH gene" promotor_-10 complement(1858148..1858167) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1858156 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" upshifts complement(1858166) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1858181..1858187) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1858196..1858214) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1858214) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1858230..1858235) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1858291..1858659) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" /label="rtp CDS" gene complement(1858291..1858659) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /label="rtp gene" promotor_-10 complement(1858694..1858712) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1858717) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="upshifts" S_feature complement(1858719..1858838) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1858724..1858732) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1858830..1858849) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1858838) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1858840..1858936) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1858864..1858871) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1858959..1859675) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" /label="yoxD CDS" gene complement(1858959..1859675) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /label="yoxD gene" downshifts complement(1858981) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1859713..1859732) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1859722) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1859748..1859751) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1859776..1859782 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1859796..1859814 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1859801 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="upshifts" CDS 1859826..1860131 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " /label="yoxC CDS" gene 1859826..1860131 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /label="yoxC gene" downshifts 1860115 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" /label="downshifts" CDS 1860202..1860972 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" /label="yoxB CDS" gene 1860202..1860972 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /label="yoxB gene" promotor_-35 1860954..1860961 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1860973 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1860976..1860995 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1861016..1861549 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" /label="yoaA CDS" gene 1861016..1861549 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /label="yoaA gene" S_feature 1861550..1861635 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1861592 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1861628..1862872) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" /label="yoaB CDS" gene complement(1861628..1862872) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /label="yoaB gene" S_feature 1861637..1862376 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1861642) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1862873..1862965) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1862966..1864429) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" /label="yoaC CDS" gene complement(1862966..1864429) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /label="yoaC gene" CDS complement(1864447..1865481) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" /label="yoaD CDS" gene complement(1864447..1865481) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /label="yoaD gene" S_feature complement(1865493..1865564) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1865536) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1865565..1865656) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswF RNA" gene complement(1865565..1865656) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /label="mswF gene" promotor_-10 complement(1865684..1865703) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1865696) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1865718..1865725) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1865738..1865745 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1865759..1865778 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1865763 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="upshifts" CDS 1865805..1867847 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" /label="yoaE CDS" gene 1865805..1867847 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /label="yoaE gene" promotor_-35 1867855..1867864 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1867877..1867892 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1867880 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1867914..1868207 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" /label="yoaF CDS" gene 1867914..1868207 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /label="yoaF gene" downshifts 1868187 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1868232..1868579) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1868263) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1868580..1868984) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" /label="yoaG CDS" gene complement(1868580..1868984) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /label="yoaG gene" S_feature complement(1868985..1869080) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1869070..1869085) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1869070..1869189) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" /label="hypothetical protein CDS" gene complement(1869070..1869189) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /label="gene" upshifts complement(1869080) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1869098..1869107) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1869185..1869191 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1869205..1869216 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1869216..1869424 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1869216 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1869259..1869381 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" /label="conserved hypothetical protein CDS" gene 1869259..1869381 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /label="gene" CDS 1869425..1869718 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" /label="yozQ CDS" gene 1869425..1869718 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /label="yozQ gene" S_feature 1869719..1869812 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1869769 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1869834..1871519) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" /label="yoaH CDS" gene complement(1869834..1871519) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /label="yoaH gene" downshifts complement(1869846) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(1871520..1871607) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1871599..1871617) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1871607) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1871631..1871638) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1871776..1871785 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1871795 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1871798..1871817 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1871844..1873295 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" /label="yoaI CDS" gene 1871844..1873295 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /label="yoaI gene" downshifts 1873271 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1873332..1874030) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" /label="exlX CDS" gene complement(1873332..1874030) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /label="exlX gene" downshifts complement(1873347) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1874065..1874084) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1874084) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1874086..1874299) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1874098..1874105) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1874300..1874977) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" /label="yoaK CDS" gene complement(1874300..1874977) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /label="yoaK gene" S_feature complement(1874978..1877467) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1875150..1876187 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" /label="pelB CDS" gene 1875150..1876187 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /label="pelB gene" promotor_-35 1876384..1876390 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1876405..1876416 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1876417 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1876444..1877127 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" /label="yoaM CDS" gene 1876444..1877127 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /label="yoaM gene" CDS complement(1877468..1877773) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " /label="yozS CDS" gene complement(1877468..1877773) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /label="yozS gene" S_feature complement(1877774..1877875) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1877854..1877873) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1877875) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1877888..1877895) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1877903..1878005) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1877945) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1878006..1879184) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" /label="oxdD CDS" gene complement(1878006..1879184) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /label="oxdD gene" promotor_-10 complement(1879210..1879229) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1879229) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1879243..1879252) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1879307..1879795) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" /label="yoaO CDS" gene complement(1879307..1879795) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /label="yoaO gene" downshifts complement(1879332) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" /label="downshifts" CDS complement(1879820..1879975) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" /label="hypothetical protein CDS" gene complement(1879820..1879975) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /label="gene" CDS complement(1880015..1880770) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" /label="yoaP CDS" gene complement(1880015..1880770) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /label="yoaP gene" promotor_-35 1881023..1881028 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1881044..1881062 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1881059 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="upshifts" CDS 1881078..1881434 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" /label="yoaQ CDS" gene 1881078..1881434 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /label="yoaQ gene" CDS complement(1881393..1881632) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" /label="yozT CDS" gene complement(1881393..1881632) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /label="yozT gene" S_feature 1881435..1881871 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1881633..1881734) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1881735..1882232) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" /label="yozF CDS" gene complement(1881735..1882232) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /label="yozF gene" S_feature complement(1882233..1882332) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1882333..1883244) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" /label="yoaR CDS" gene complement(1882333..1883244) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /label="yoaR gene" promotor_-10 complement(1883266..1883277) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1883268) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1883292..1883298) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1883528..1883535 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1883544 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1883550..1883569 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1883591..1884073 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" /label="yoaS CDS" gene 1883591..1884073 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /label="yoaS gene" CDS 1884083..1884337 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" /label="yozG CDS" gene 1884083..1884337 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /label="yozG gene" S_feature 1884338..1884442 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1884443..1885237 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" /label="yoaT CDS" gene 1884443..1885237 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /label="yoaT gene" S_feature 1885238..1886248 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1885361..1886233) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" /label="yoaU CDS" gene complement(1885361..1886233) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /label="yoaU gene" CDS 1886334..1887212 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" /label="yoaV CDS" gene 1886334..1887212 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /label="yoaV gene" S_feature complement(1887325..1887384) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1887360) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1887385..1887816) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" /label="yoaW CDS" gene complement(1887385..1887816) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /label="yoaW gene" promotor_-10 complement(1887836..1887855) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1887844) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1887846..1888079) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1887869..1887875) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1888080..1888098) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1888080..1888712) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" /label="yoaZ CDS" gene complement(1888080..1888712) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /label="yoaZ gene" upshifts complement(1888086) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1888114..1888119) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1888850..1888857 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1888872..1888891 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1888876 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="upshifts" CDS 1888938..1889858 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" /label="penP CDS" gene 1888938..1889858 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /label="penP gene" promotor_-10 complement(1889369..1889388) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1889384) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1889403..1889410) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1889859..1890516 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1890355..1890717) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" /label="yobA CDS" gene complement(1890355..1890717) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /label="yobA gene" CDS complement(1890778..1890990) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" /label="yozU CDS" gene complement(1890778..1890990) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo /label="yozU gene" promotor_-35 1891029..1891036 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1891051..1891070 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1891054 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="upshifts" CDS 1891094..1891357 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" /label="yobB CDS" gene 1891094..1891357 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /label="yobB gene" downshifts 1891335 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1891734..1894334) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" /label="yppS CDS" gene complement(1891734..1894334) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /label="yppS gene" S_feature complement(1894335..1894444) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 1894360..1894367 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1894382..1894401 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1894390..1895017 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 1894390 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1894434..1894453) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1894444) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1894468..1894474) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1894490..1894949) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(1894532) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1894994) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(1895004..1895645) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" /label="xynA CDS" gene complement(1895004..1895645) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /label="xynA gene" S_feature complement(1895646..1895763) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(1895740..1895759) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1895763) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1895773..1895775) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1896273..1896512) /gene="yozV" /locus_tag="BSU_18849" /old_locus_tag="BSU18849" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="YP_003097736.1" /db_xref="EnsemblGenomes-Gn:BSU18849" /db_xref="EnsemblGenomes-Tr:CAX52631" /db_xref="GOA:C0H423" /db_xref="InterPro:IPR007829" /db_xref="UniProtKB/Swiss-Prot:C0H423" /translation="MVSKKNKIVAALLAFFFGGLGIHKFYLGRVGQGILYILFCWTGI PSIIAFIEFIIFLCGSEEGFDQKYNFYYFQQQSKA*" /label="yozV CDS" gene complement(1896273..1896512) /gene="yozV" /locus_tag="BSU_18849" /old_locus_tag="BSU18849" /label="yozV gene" downshifts complement(1896293) /Source="Nicolas_upshifts" /id="D1030" /incds=0 /nref=31 /ntot=127 /MaxReadThrough="3.22282" /MaxDrop="3.97488" /score="-1.08247697" /energy="-4.5" /TU="U1526" /idTUdmin="U1526" /TUdmin="-529" /isTUend="FALSE" /label="downshifts" misc_feature complement(1896552..1896571) /Source="Nicolas_upshift_promotors" /id="U1526" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig="0.985014985014985" /xcortree=2315 /SigmaFactorBS="taaaaaatctcaaaagaatttcaaaattttcacgatttctgg cggaaaATGCATTATAATGTGAAAGCattactttaaaaatggtagcaatgaactagga g" /listShort="yozV" /listLong="S710, xynA, S709" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1896559) /Source="Nicolas_upshifts" /id="U1526" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig="0.985014985014985" /xcortree=2315 /SigmaFactorBS="taaaaaatctcaaaagaatttcaaaattttcacgatttctgg cggaaaATGCATTATAATGTGAAAGCattactttaaaaatggtagcaatgaactagga g" /listShort="yozV" /listLong="S710, xynA, S709" /label="upshifts" promotor_-35 1896618..1896625 /Source="Nicolas_upshift_promotors" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1896640..1896659 /Source="Nicolas_upshift_promotors" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1896647 /Source="Nicolas_upshifts" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" /label="upshifts" CDS 1896683..1897021 /gene="yobD" /locus_tag="BSU_18850" /old_locus_tag="BSU18850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10376821" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="transcriptional regulator (phage-related, Xre family); putative defective prophage 6" /protein_id="NP_389766.1" /db_xref="EnsemblGenomes-Gn:BSU18850" /db_xref="EnsemblGenomes-Tr:CAB13777" /db_xref="GOA:O34647" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG13497" /db_xref="UniProtKB/Swiss-Prot:O34647" /translation="MYCQRLRQLRKAHKLTMEQLAEKIGIAKSSYGGYEAESKKPPLD KLVILARLYDVSVDYILGLTDDPDPKVERKNLKEFLEKPDIHWDGYKLTPEILDPIRK ILKLVTANNN*" /label="yobD CDS" gene 1896683..1897021 /gene="yobD" /locus_tag="BSU_18850" /old_locus_tag="BSU18850" /label="yobD gene" S_feature 1897022..1897618 /Source="Nicolas_S_feature" /locus_tag="new_2056617_2057213" /HighExp="M0t90, Lbstat, Lbtran, MG 150, M40t90, MG 15, SMM, GM 25, Fru, GM-0.1" /AntisenseName="yozH" /AntisenseCor="0.41013265801279702" /AntisenseRegPval="-11.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S711" CDS complement(1897055..1897411) /gene="yozH" /locus_tag="BSU_18860" /old_locus_tag="BSU18860" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; putative defective prophage 6" /protein_id="NP_389767.2" /db_xref="EnsemblGenomes-Gn:BSU18860" /db_xref="EnsemblGenomes-Tr:CAB13778" /db_xref="SubtiList:BG13755" /db_xref="UniProtKB/Swiss-Prot:O31837" /translation="MNDLLFAAGNLHIGLGHDYLKCIALLINVKRFFSLTESYGNISD KLAVVAMKGVQFDQFEEAYKAYKETVAINQNSLVDFLSALITLIKAGEKLQKAGESLA IIMNKLLEMSPENSMK*" /label="yozH CDS" gene complement(1897055..1897411) /gene="yozH" /locus_tag="BSU_18860" /old_locus_tag="BSU18860" /label="yozH gene" CDS 1897619..1897984 /gene="yozI" /locus_tag="BSU_18870" /old_locus_tag="BSU18870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative defective prophage 6" /protein_id="NP_389768.1" /db_xref="EnsemblGenomes-Gn:BSU18870" /db_xref="EnsemblGenomes-Tr:CAB13779" /db_xref="SubtiList:BG13756" /db_xref="UniProtKB/Swiss-Prot:O31838" /translation="MPKLYTCLICGYKGLIQNPLNNDGEYQKTFDICPCCDFEYGYSE DHDVSLGFIVTPDYLIDAAIQLYRKQWIENGMKTANPEDIPEELRNGDCLKFEVLLKQ LNSLNLDTENFEIKGFNGY*" /label="yozI CDS" gene 1897619..1897984 /gene="yozI" /locus_tag="BSU_18870" /old_locus_tag="BSU18870" /label="yozI gene" S_feature complement(1897993..1899119) /Source="Nicolas_S_feature" /locus_tag="new_2057588_2058714_c" /HighExp="BC, Sw, HiOs, C90, Lbstat, M0t90, UNK1, M9-stat, HiTm, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="SigA" /TUlongPSig="0.994" /label="S712" downshifts complement(1898036) /Source="Nicolas_upshifts" /id="D1031" /incds=0 /nref=3 /ntot=99 /MaxReadThrough="3.80479" /MaxDrop="4.2268" /score="22.3776508" /energy="-7.6" /TU="U1528" /idTUdmin="U1528" /TUdmin="-513" /isTUend="FALSE" /label="downshifts" CDS 1898206..1898865 /gene="yobE" /locus_tag="BSU_18880" /old_locus_tag="BSU18880" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative SOS response associated phage protein; putative defective prophage 6" /protein_id="NP_389769.1" /db_xref="EnsemblGenomes-Gn:BSU18880" /db_xref="EnsemblGenomes-Tr:CAB13780" /db_xref="GOA:O34915" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13498" /db_xref="UniProtKB/Swiss-Prot:O34915" /translation="MCGKFTLFSEFDDIIEQFNIDQFLPEGEYHPSYNVAPSQNILTI INDGSNNRLGKLRWGLIPPCAKDEKIGYKMINARAETLAEKPSFRKPLGSKRCIIPAD SFYEWKRLDPKTKIPMRIKLKSSNLFAFAGLYEKWNTLEGNLLYTCTIITIKPSELME DIHDRMPVILTDENKKEWLNPKNTDPDYLQSLLLPYDADDMEAYQVSSLVNSPELIES H*" /label="yobE CDS" gene 1898206..1898865 /gene="yobE" /locus_tag="BSU_18880" /old_locus_tag="BSU18880" /label="yobE gene" downshifts 1898943 /Source="Nicolas_upshifts" /id="D1032" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="1.22982" /MaxDrop="2.96245" /score="5.95470205" /energy="-19.6" /TU="NA" /idTUdmin="U1527" /TUdmin=990 /isTUend="FALSE" /label="downshifts" CDS complement(1899120..1900043) /gene="yobF" /locus_tag="BSU_18890" /old_locus_tag="BSU18890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389770.1" /db_xref="EnsemblGenomes-Gn:BSU18890" /db_xref="EnsemblGenomes-Tr:CAB13781" /db_xref="SubtiList:BG13499" /db_xref="UniProtKB/Swiss-Prot:O34780" /translation="MLVYIGNGHYCYSNSTAMFLSSIGENVSPQLVEILTGVGLGAMI EYEKNLYFSMRDPDDGINYALNILGFTAEEHQQASDLDDPFPLLKQQIKQNPVILGPL DMGELTYHPNHKNLNGSDHYVLGYQMDNENIYVQDPAGFPFVPLSLDQFKKAWMAERI PYRKGINKYWSTAKKVVTLDNNEIYERAIDYFKRTYRKFEKVDIGLIGREAICFYADQ LLNAPITADTIRHTTFFLFQLSARRANDYAMYFKDRHSHLSVLKTEQAKVFGICHSMS VNKDWKGISEKLMKLADLEDNFRLELLKVGY*" /label="yobF CDS" gene complement(1899120..1900043) /gene="yobF" /locus_tag="BSU_18890" /old_locus_tag="BSU18890" /label="yobF gene" promotor_-10 complement(1899899..1899918) /Source="Nicolas_upshift_promotors" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1899902) /Source="Nicolas_upshifts" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1899930..1899937) /Source="Nicolas_upshift_promotors" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1900054..1900073) /Source="Nicolas_upshift_promotors" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" /label="promotor_-10" upshifts complement(1900075) /Source="Nicolas_upshifts" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" /label="upshifts" promotor_-35 complement(1900088..1900095) /Source="Nicolas_upshift_promotors" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" /label="promotor_-35" CDS complement(1900096..1900269) /gene="yozW" /locus_tag="BSU_18898" /old_locus_tag="BSU18898" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; putative defective prophage 6" /protein_id="YP_003097737.1" /db_xref="EnsemblGenomes-Gn:BSU18898" /db_xref="EnsemblGenomes-Tr:CAX52632" /db_xref="UniProtKB/Swiss-Prot:C0H424" /translation="MTEIKANSTVMIHVLADETLSSIKREYVEVDRKTEIGEKIIIVD KNDPDDEYENGAI*" /label="yozW CDS" gene complement(1900096..1900269) /gene="yozW" /locus_tag="BSU_18898" /old_locus_tag="BSU18898" /label="yozW gene" CDS 1900414..1900638 /gene="yozX" /locus_tag="BSU_18899" /old_locus_tag="BSU18899" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="YP_003097738.1" /db_xref="EnsemblGenomes-Gn:BSU18899" /db_xref="EnsemblGenomes-Tr:CAX52633" /db_xref="UniProtKB/Swiss-Prot:C0H425" /translation="MNFLLDLFTNWTFDKVLDYTLAAVIWSVFKSRSKQNKYPGYFEK IRRYRNLHPLLRSLSMRVLLSITIHPYMFS*" /label="yozX CDS" gene 1900414..1900638 /gene="yozX" /locus_tag="BSU_18899" /old_locus_tag="BSU18899" /label="yozX gene" CDS complement(1900642..1901097) /gene="yozJ" /locus_tag="BSU_18900" /old_locus_tag="BSU18900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389771.1" /db_xref="EnsemblGenomes-Gn:BSU18900" /db_xref="EnsemblGenomes-Tr:CAB13782" /db_xref="SubtiList:BG13757" /db_xref="UniProtKB/Swiss-Prot:O31839" /translation="MADRYVLIEVNEDGEGRLKDEAVTWIDFRLSIVDFNASEGLNQL MEQISKDVKDELVLVLFNYRVKSSYDSWSGATEYEDFFDVEFFKVIKKNYKKFYQGLV TVELDVGINGFDNIESMPTDSNQNYYRNLIAEWEEFYNEDFIPLSLNKR*" /label="yozJ CDS" gene complement(1900642..1901097) /gene="yozJ" /locus_tag="BSU_18900" /old_locus_tag="BSU18900" /label="yozJ gene" promotor_-35 1901157..1901164 /Source="Nicolas_upshift_promotors" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1901179..1901198 /Source="Nicolas_upshift_promotors" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1901183 /Source="Nicolas_upshifts" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" /label="upshifts" CDS 1901222..1901482 /gene="yozY" /locus_tag="BSU_18908" /old_locus_tag="BSU18908" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="YP_003097739.1" /db_xref="EnsemblGenomes-Gn:BSU18908" /db_xref="EnsemblGenomes-Tr:CAX52634" /db_xref="UniProtKB/Swiss-Prot:C0H426" /translation="MNLRKILLSSALSLGMLVSAAPVLATSSSSEVIVKSDEYDYDTI YQLSPLPNFKPSIEYNGYTYTLTRYYFDYSIQFYTAIYTKVV*" /label="yozY CDS" gene 1901222..1901482 /gene="yozY" /locus_tag="BSU_18908" /old_locus_tag="BSU18908" /label="yozY gene" downshifts 1901429 /Source="Nicolas_upshifts" /id="D1033" /incds=0 /nref=1 /ntot=221 /MaxReadThrough="4.57606" /MaxDrop="3.58254" /score="4.613667" /energy="-8.7" /TU="U1530" /idTUdmin="U1530" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" promotor_-35 1901897..1901900 /Source="Nicolas_upshift_promotors" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1901914..1901933 /Source="Nicolas_upshift_promotors" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1901931 /Source="Nicolas_upshifts" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1902043 /Source="Nicolas_upshifts" /id="D1034" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="3.18248" /MaxDrop="3.66335" /score="32.4789235" /energy="-13.7" /TU="U1530,U1531" /idTUdmin="U1530" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS 1902260..1902400 /gene="yozZ" /locus_tag="BSU_18909" /old_locus_tag="BSU18909" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage holin (fragment)" /db_xref="PSEUDO:CAX52635.1" /translation="MTVFGDDLTEKFNALLTFLTALGIIVDPTTQGISDSEQAMDYDS PR*" /label="yozZ CDS" gene 1902260..1902400 /gene="yozZ" /locus_tag="BSU_18909" /old_locus_tag="BSU18909" /pseudo /label="yozZ gene" downshifts 1902397 /Source="Nicolas_upshifts" /id="D1035" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.30104" /MaxDrop="4.04304" /score="32.4789235" /energy="-13.7" /TU="NA" /idTUdmin="U1531" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 1902482..1902489 /Source="Nicolas_upshift_promotors" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1902501..1902520 /Source="Nicolas_upshift_promotors" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1902502 /Source="Nicolas_upshifts" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" /label="upshifts" CDS 1902555..1903670 /gene="rapK" /locus_tag="BSU_18910" /old_locus_tag="BSU18910" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:16816200, 25225273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200, 25225273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_389772.1" /db_xref="EnsemblGenomes-Gn:BSU18910" /db_xref="EnsemblGenomes-Tr:CAB13783" /db_xref="GOA:O34930" /db_xref="InterPro:IPR011990" /db_xref="SubtiList:BG12664" /db_xref="UniProtKB/Swiss-Prot:O34930" /translation="MSKIASEVVATTLNDWYIAIKKQKVDESIKYYSEIKKLFDEMEE DQEVLAYYSLLEERHKMLLHSSRGEPLQKHTYFTEDNQNFITKTNDKLEYNFYLFEAM YEAYNKNYDRAINLYGLAEKKLAEIPDEIEAAEFYSKVSYLYTLVKQSIVAQHYIKNA ISIYKRHPDYKCKLATSTMIAAANYADMKRFEEAEQYYLEAIDIAKETKDEFLKAQLF HNLSIVYSDWNKPDKCIESLEKAIGNESWLHSIYYINSLFMMIKELFKIDEKMKAINF YNKAQERLILMENKVYEAKISILYNLYCGELKNNFNNCISNIEFLKQQNELESVDELS YIAAKRFESIGAFEEATSFFNAKIWAEQKMNQVEGIL*" /label="rapK CDS" gene 1902555..1903670 /gene="rapK" /locus_tag="BSU_18910" /old_locus_tag="BSU18910" /label="rapK gene" promotor_-35 1903394..1903402 /Source="Nicolas_upshift_promotors" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1903411 /Source="Nicolas_upshifts" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1903414..1903432 /Source="Nicolas_upshift_promotors" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1903667..1903789 /gene="phrK" /locus_tag="BSU_18920" /old_locus_tag="BSU18920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11587781, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11587781, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapK" /protein_id="NP_389773.1" /db_xref="EnsemblGenomes-Gn:BSU18920" /db_xref="EnsemblGenomes-Tr:CAB13784" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG12646" /db_xref="UniProtKB/Swiss-Prot:O31840" /translation="MKKLVLCVSILAVILSGVALTQLSTDSPSNIQVAERPVGG*" /label="phrK CDS" gene 1903667..1903789 /gene="phrK" /locus_tag="BSU_18920" /old_locus_tag="BSU18920" /label="phrK gene" downshifts 1903783 /Source="Nicolas_upshifts" /id="D1036" /incds=0 /nref=232 /ntot=252 /MaxReadThrough="2.33184" /MaxDrop="6.45227" /score="9.89565332" /energy="-10.4" /TU="NA" /idTUdmin="U1532" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1903915..1904568) /gene="yobHc" /locus_tag="BSU_18930" /old_locus_tag="BSU18930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative DNA phage repair protein; putative defective prophage 6" /db_xref="EnsemblGenomes-Gn:BSU18930" /db_xref="EnsemblGenomes-Tr:CAB13785" /db_xref="GOA:C0SPA8" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="PSEUDO:CAB13785.2" /db_xref="SubtiList:BG13500" /db_xref="UniProtKB/Swiss-Prot:C0SPA8" /translation="MAKAIQSSMWREFGLMCTVGIGDNMLLSKLALDLESKKTKSGIA RWRYEDVPNRLWKVRPLSKMWGIGGRMERNLNRMGISTVGQLAKFPLELLEKKFGIMG NQLYYHAHGIDLSEIGAPLMQGQISFGKSQILFRDYTKREEIKAVLLEICEEVARRAR TYNKVGRTISLGIGYSKDELGGGFHRSKTIDFPTNITMDIYKCCLMFFNKFYSGKKQ* " /label="yobHc CDS" gene complement(1903915..1904568) /gene="yobHc" /locus_tag="BSU_18930" /old_locus_tag="BSU18930" /pseudo /label="yobHc gene" downshifts complement(1904189) /Source="Nicolas_upshifts" /id="D1037" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="1.36944" /MaxDrop="2.50062" /score="17.2005818" /energy="-10" /TU="NA" /idTUdmin="U1535" /TUdmin=1628 /isTUend="FALSE" /label="downshifts" CDS complement(1904605..1904952) /gene="yobHm" /locus_tag="BSU_18940" /old_locus_tag="BSU18940" /function="16.9: Replicate" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12137951; Product type h: extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage DNA repair protein fragment; putative defective prophage 6" /db_xref="EnsemblGenomes-Gn:BSU18940" /db_xref="EnsemblGenomes-Tr:CAB13786" /db_xref="GOA:O31841" /db_xref="InterPro:IPR001126" /db_xref="PSEUDO:CAB13786.1" /db_xref="SubtiList:BG13758" /db_xref="UniProtKB/Swiss-Prot:O31841" /translation="MTDYSQFPRENILCVDMKSFYASVSAVAMGLNPLTCYLAVVGNT DRQGSVVLAASPALKKDFGIKTGSRLFEIPEDPRIYIVNPQMKLFIRVSTEITKLFYR FVPEKCVHTYSID*" /label="yobHm CDS" gene complement(1904605..1904952) /gene="yobHm" /locus_tag="BSU_18940" /old_locus_tag="BSU18940" /pseudo /label="yobHm gene" CDS complement(1904945..1905238) /gene="yozL" /locus_tag="BSU_18950" /old_locus_tag="BSU18950" /function="16.6: Maintain" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein of phage origin; putative defective prophage 6" /protein_id="NP_389776.1" /db_xref="EnsemblGenomes-Gn:BSU18950" /db_xref="EnsemblGenomes-Tr:CAB13787" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG13759" /db_xref="UniProtKB/Swiss-Prot:O31842" /translation="MMLEQLIQLKQDLIDGSKVEKPSLDDKQIDEMDILVSEALEFNK ELKFKLFNKGFVENVTGRVHYINFEQQKLHVKDQNDNTVYINMNNIIRVIYND*" /label="yozL CDS" gene complement(1904945..1905238) /gene="yozL" /locus_tag="BSU_18950" /old_locus_tag="BSU18950" /label="yozL gene" upshifts 1905389 /Source="Nicolas_upshifts" /id="U1534" /multdbtbs="-" /comp="M1" /sig="SigA" /pcomp="0.340659340659341" /psig="0.65034965034965" /xcortree=472 /SigmaFactorBS="tatagatcagaacaaaagttcgatgtaaatgttggtaataaa atataaaggtcaataatgaTATCCGTAGTATTAATAAAGgagagattcttttcgacga g" /listShort="yozM" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1905390..1905409 /Source="Nicolas_upshift_promotors" /id="U1534" /multdbtbs="-" /comp="M1" /sig="SigA" /pcomp="0.340659340659341" /psig="0.65034965034965" /xcortree=472 /SigmaFactorBS="tatagatcagaacaaaagttcgatgtaaatgttggtaataaa atataaaggtcaataatgaTATCCGTAGTATTAATAAAGgagagattcttttcgacga g" /listShort="yozM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1905447..1905782 /gene="yozM" /locus_tag="BSU_18960" /old_locus_tag="BSU18960" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative bacteriophage protein; putative defective prophage 6" /protein_id="NP_389777.1" /db_xref="EnsemblGenomes-Gn:BSU18960" /db_xref="EnsemblGenomes-Tr:CAB13788" /db_xref="SubtiList:BG13760" /db_xref="UniProtKB/Swiss-Prot:O31843" /translation="MKKRLIGFLVLVPALIMWGITLIESNKKTPVEVLESAWDEFGLF SFEIGITDPAITIGMDQTKSEAKLREYLKDNLSREAKEKYKIYIFKDDTDKLEKEHQE YLKENNLNK*" /label="yozM CDS" gene 1905447..1905782 /gene="yozM" /locus_tag="BSU_18960" /old_locus_tag="BSU18960" /label="yozM gene" promotor_no_box complement(1905821..1905921) /Source="Nicolas_upshift_promotors" /id="U1535" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.68031968031968" /psig="0.040959040959041" /xcortree=286 /SigmaFactorBS="aaagcgttggtgactgcattagagtctaaaaactacatatcc tcttttaaagaagatagagagagattacgtgtgaatactaaaaaaaaataaagaataa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(1905828) /Source="Nicolas_upshifts" /id="D1038" /incds=0 /nref=148 /ntot=238 /MaxReadThrough="2.4012" /MaxDrop="4.9328" /score="17.2005818" /energy="-10" /TU="NA" /idTUdmin="U1535" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1905829..1909434) /gene="yobI" /locus_tag="BSU_18970" /old_locus_tag="BSU18970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15128444; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage repair NTPase with transmembrane helices; putative defective prophage 6" /protein_id="NP_389778.1" /db_xref="EnsemblGenomes-Gn:BSU18970" /db_xref="EnsemblGenomes-Tr:CAB13789" /db_xref="GOA:O34784" /db_xref="InterPro:IPR011646" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13501" /db_xref="UniProtKB/Swiss-Prot:O34784" /translation="MGEIKKKFVQWLEKLLIRLKEPNVKEESLFEDLSPSNDVDTDGK YSKALSWGLENKKVKNIALTGPYGSGKSSILNTFQKQYSREYSFLNISLATFNTDTDD MENKLEKSILQQMIYRVHDRTIPFSRFKRIKHIRTKSIIINLIFFFAFIIVGIYLFKP DALKGIYAETLVSRSLGTEDQQQIRLTILLALFFIVYPLLAYKRIYHFVRANLKLNKV TIANTTLEKNTGEENSSIFDKYLDEILYFFEASKYNVVIFEDLDRFNNIGIFERLREL NELINNSEQIDRRVVFIYAIKDDIFGDADTEKLTRDRTKFFDFIIPVIPIINASNSGD ILKKKIKHSPYSDLINTHFLEDVTIYIDDMRVLKNIFNEFVIYQQKLSAIDLDPNKML AMIIYKNIYPVDFSKLQYNKGLVYEIFQKKQLIIEEQIKLINAKIQQLERKLANIEVE SLKSIAELNFIYLSELEISNLNSNYDINIDGEVFRGNTSNKDRFFEKLKNADTIYCYL RNRNGPATIKEIATVFGRKPNYFEREDAIKAIEKNEIQKFKKELLELEREKQEIRAQS LQVLITKMNSKDVFSDKLYEKKLLVYLLRHGYIDEMYNHYITYFYPESLSLSDIKFVF SIKNHESLPYSFELDNIGKIMSKLVGAEFKQIEVLNFHLLNYIMDHSEYRNYYDSIIE RLANGSKESVTFIDGFKERAINKAAFIQSISSKWDDFWSFIELRSNYTQQKKEEYLSD ILTYADIADIIRMNKESVMSFTLSKYLNLLSLVSDEEKIKELLLKLQVKFKSLDHLLN SETIYDFVVQRNLYEINIKTLSVILNDAPNITYAAVKNSDQQAVINYVNDNIDIFVEK VLLTEEIEEPEESFLELLNREDLDKRVKHAMIMKKTFAISDIGELIKELWPIVIRENK MVACWSNVITSYVEYNKKMPDFLIAFLNNPVNRKELSKNNIEAFDDKFDEAILEDISE EIINSRDITDETFEVLIASIQSWIYFPLGNVSEKRAKLLIDNDLLSLTPENFKELKLN FDTLHIQLALRNPDEFIDKQGDFSLDANDIKQLIDSNELSQFNKEIFVQHLNSNCLTD GNNDILKDTIYFINEHNLKITNELLTFLLESPTTLDTRLSLLAGQIKHIDNESITEFL TKIGEPYSEIAEKGRRIKISNNRTNKALVTALESKNYISSFKEDRERLRVNTKKK*" /label="yobI CDS" gene complement(1905829..1909434) /gene="yobI" /locus_tag="BSU_18970" /old_locus_tag="BSU18970" /label="yobI gene" upshifts complement(1905861) /Source="Nicolas_upshifts" /id="U1535" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.68031968031968" /psig="0.040959040959041" /xcortree=286 /SigmaFactorBS="aaagcgttggtgactgcattagagtctaaaaactacatatcc tcttttaaagaagatagagagagattacgtgtgaatactaaaaaaaaataaagaataa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1909435..1909579) /Source="Nicolas_S_feature" /locus_tag="new_2069030_2069174_c" /HighExp="LBGstat, Lbstat, M0t90, T3.0H, T1.30H, T3.30H, MG 150, T2.30H, T4.0H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.936" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S713" misc_feature complement(1909572..1909591) /Source="Nicolas_upshift_promotors" /id="U1536" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=3220 /SigmaFactorBS="tgtgttgtttattgatcatctttttttcagaaacttttaatg ccctttCATGTTACAATTAATAGTGAatttcaactggcgataaaggactatattagat g" /listShort="S713, yobI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1909579) /Source="Nicolas_upshifts" /id="U1536" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=3220 /SigmaFactorBS="tgtgttgtttattgatcatctttttttcagaaacttttaatg ccctttCATGTTACAATTAATAGTGAatttcaactggcgataaaggactatattagat g" /listShort="S713, yobI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1909581..1909666) /Source="Nicolas_S_feature" /locus_tag="new_2069176_2069261_c" /HighExp="LBGstat, C30, Lbstat, M0t90, GM 120, GM 25, GM 150, nit, GM 90, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigWXY" /TUshortPSig="0.936, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S714" CDS complement(1909667..1909966) /gene="yoyA" /locus_tag="BSU_18979" /old_locus_tag="BSU18979" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative fragment of phage protein; putative defective prophage 6" /db_xref="PSEUDO:CAX52636.1" /translation="MATEGYGGNNSAPSRSIGFSEFCETLEKNEVVKPENKKSSLDLN NSLDYWKSRFNPGGNLSALDSQVLDIIKKAYNLGMVNKDNMLLRNEAINAYKNSI*" /label="yoyA CDS" gene complement(1909667..1909966) /gene="yoyA" /locus_tag="BSU_18979" /old_locus_tag="BSU18979" /pseudo /label="yoyA gene" S_feature complement(1909967..1910104) /Source="Nicolas_S_feature" /locus_tag="new_2069562_2069699_c" /HighExp="LBGstat, C30, MG 150, GM 150, M0t90, Lbstat, GM 25, GM 90, GM 120, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigWXY" /TUshortPSig="0.936, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S715" promotor_-10 complement(1910082..1910100) /Source="Nicolas_upshift_promotors" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1910104) /Source="Nicolas_upshifts" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1910114..1910120) /Source="Nicolas_upshift_promotors" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(1910137..1910520) /gene="asrE" /locus_tag="BSU_misc_RNA_74" /product="small regulatory antitoxin RNA, toxin-antitoxin type I system (BsrE/AsrE)" /experiment="publication(s) with functional evidences, PMID:18948176, 23059907, 24576839, 26565032, 26940229" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23059907, 24576839, 26565032, 26940229; Product type n: RNA" /label="asrE RNA" gene complement(1910137..1910520) /gene="asrE" /locus_tag="BSU_misc_RNA_74" /label="asrE gene" S_feature complement(1910151..1910387) /Source="Nicolas_S_feature" /locus_tag="new_2069746_2069982_c" /HighExp="Salt, Etha, S4, LoTm, dia5, Diami, S5, MG 120, S3, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.518, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S716" promotor_-35 1910184..1910186 /Source="Nicolas_upshift_promotors" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1910194) /Source="Nicolas_upshifts" /id="D1039" /incds=0 /nref=39 /ntot=216 /MaxReadThrough="3.37292" /MaxDrop="5.0558" /score="17.2005818" /energy="-10" /TU="U1541" /idTUdmin="U1539" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 1910202..1910221 /Source="Nicolas_upshift_promotors" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1910207 /Source="Nicolas_upshifts" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" /label="upshifts" S_feature 1910229..1910382 /Source="Nicolas_S_feature" /locus_tag="new_2069824_2069977" /HighExp="T1.30H, B60, T2.0H, M9-stat, BT, T0.30H, B36, T1.0H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87861900000000004" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S717" CDS 1910288..1910380 /gene="bsrE" /locus_tag="BSU_18978" /old_locus_tag="BSU18978" /experiment="publication(s) with functional evidences, PMID:26565032, 26940229" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26565032, 26940229; Product type f: factor" /codon_start=1 /transl_table=11 /product="type I toxin (BsrE/AsrE)" /protein_id="YP_009513965.1" /translation="MSTFQALMLMLAIGSFIIALLTYIEKIDLP*" /label="bsrE CDS" gene 1910288..1910380 /gene="bsrE" /locus_tag="BSU_18978" /old_locus_tag="BSU18978" /label="bsrE gene" downshifts 1910339 /Source="Nicolas_upshifts" /id="D1040" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="6.71009" /MaxDrop="3.13767" /score="33.1812693" /energy="-14.4" /TU="U1538" /idTUdmin="U1538" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1910389..1910523) /Source="Nicolas_S_feature" /locus_tag="new_2069984_2070118_c" /HighExp="T-0.40H, T0.0H, T0.30H, Salt, S4, M9-stat, T-1.10H, S7, B60, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.518, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S718" downshifts 1910405 /Source="Nicolas_upshifts" /id="D1041" /incds=0 /nref=135 /ntot=196 /MaxReadThrough="2.41468" /MaxDrop="5.72925" /score="33.1812693" /energy="-14.4" /TU="NA" /idTUdmin="U1538" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1910432) /Source="Nicolas_upshifts" /id="D1042" /incds=0 /nref=13 /ntot=114 /MaxReadThrough="6.34283" /MaxDrop="4.1536" /score="3.24083135" /energy="-14.3" /TU="U1539,U1541" /idTUdmin="U1539" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" upshifts complement(1910523) /Source="Nicolas_upshifts" /id="U1539" /multdbtbs="-" /comp="M3" /sig="SigA" /pcomp="0.44955044955045" /psig="0.518481518481518" /xcortree=755 /SigmaFactorBS="cttgaggtttattgtaatgcatttcacggaaaatgtgttata atcagtttTAcaatacattacagtgcatttctttaatgagaaatgcataaaataaaaa a" /listShort="S718, S716" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1910525..1910648) /Source="Nicolas_S_feature" /locus_tag="new_2070120_2070243_c" /HighExp="T-0.40H, T0.0H, T0.30H, Salt, T-1.10H, T1.0H, T-1.40H, Etha, SMMPr, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S719" misc_feature complement(1910532..1910533) /Source="Nicolas_upshift_promotors" /id="U1539" /multdbtbs="-" /comp="M3" /sig="SigA" /pcomp="0.44955044955045" /psig="0.518481518481518" /xcortree=755 /SigmaFactorBS="cttgaggtttattgtaatgcatttcacggaaaatgtgttata atcagtttTAcaatacattacagtgcatttctttaatgagaaatgcataaaataaaaa a" /listShort="S718, S716" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(1910649..1911491) /gene="yobJ" /locus_tag="BSU_18980" /old_locus_tag="BSU18980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11866510" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function; putative defective prophage 6" /protein_id="NP_389779.1" /db_xref="EnsemblGenomes-Gn:BSU18980" /db_xref="EnsemblGenomes-Tr:CAB13790" /db_xref="GOA:O34774" /db_xref="SubtiList:BG13502" /db_xref="UniProtKB/Swiss-Prot:O34774" /translation="MELLDIWNWIQQNGILTAVITGIVALLFNQRQKSIERFYSQSGE TLEKILEPMYYSLKEIKNEEDENHKMVLIEKFFEEYSGKKGKLSKLRNILLIDQILNT EDCFREYILNKNSENRKKLFYKMRMLDQAVNKEYRSIFVTLNKNYNWYKVLFRTNYIL SAVFVFVRWFKETLAFFVGASAFAFIPLLYDKYLGEQVLGNWLEVNKLIFGLSCSALY IFWIIHYFLLKDTMQRKDEISLFQEWFDKTKLGKWTNKNVWGKIGNWNVERRARRVRN DEDV*" /label="yobJ CDS" gene complement(1910649..1911491) /gene="yobJ" /locus_tag="BSU_18980" /old_locus_tag="BSU18980" /label="yobJ gene" promotor_-35 1910986..1910989 /Source="Nicolas_upshift_promotors" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1910999 /Source="Nicolas_upshifts" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1911005..1911009 /Source="Nicolas_upshift_promotors" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1911517..1911532) /Source="Nicolas_upshift_promotors" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" /label="promotor_-10" upshifts complement(1911518) /Source="Nicolas_upshifts" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" /label="upshifts" S_feature complement(1911520..1911602) /Source="Nicolas_S_feature" /locus_tag="new_2071115_2071197_c" /HighExp="MG 150, T-3.40H, Cold, SMM, Lbstat, SMMPr, ferm, T-2.40H, Fru, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S720" promotor_-35 complement(1911544..1911553) /Source="Nicolas_upshift_promotors" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" /label="promotor_-35" S_feature complement(1911604..1911690) /Source="Nicolas_S_feature" /locus_tag="new_2071199_2071285_c" /HighExp="Lbstat, M0t90, HiOs, HiTm, M40t90, dia15, S2, S1, T-0.40H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S721" downshifts complement(1911647) /Source="Nicolas_upshifts" /id="D1043" /incds=0 /nref=5 /ntot=191 /MaxReadThrough="4.07519" /MaxDrop="4.09712" /score="-3.79237769" /energy="-8.4" /TU="U1542" /idTUdmin="U1542" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(1911691..1912149) /gene="rttM" /locus_tag="BSU_18990" /old_locus_tag="BSU18990" /function="17.2: Prophage functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin inhibiting Rnase RttL" /protein_id="NP_389780.1" /db_xref="EnsemblGenomes-Gn:BSU18990" /db_xref="EnsemblGenomes-Tr:CAB13791" /db_xref="InterPro:IPR018958" /db_xref="PDB:2PRV" /db_xref="SubtiList:BG13503" /db_xref="UniProtKB/Swiss-Prot:O34596" /translation="MIYSKVENFINENKQNAIFTEGASHENIGRIEENLQCDLPNSYK WFLEKYGAGGLFGVLVLGYNFDHASVVNRTNEYKEHYGLTDGLVVIEDVDYFAYCLDT NKMKDGECPVVEWDRVIGYQDTVADSFIEFFYNKIQEAKDDWDEDEDWDD*" /label="rttM CDS" gene complement(1911691..1912149) /gene="rttM" /locus_tag="BSU_18990" /old_locus_tag="BSU18990" /label="rttM gene" CDS complement(1912159..1913961) /gene="rttL" /locus_tag="BSU_19000" /old_locus_tag="BSU19000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phage toxin ribonuclease; putative defective prophage 6" /protein_id="NP_389781.1" /db_xref="EnsemblGenomes-Gn:BSU19000" /db_xref="EnsemblGenomes-Tr:CAB13792" /db_xref="GOA:O34330" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR026834" /db_xref="SubtiList:BG13504" /db_xref="UniProtKB/Swiss-Prot:O34330" /translation="MKVFEADSLLFEADKRTKEYKELRSQMVKLKKAFKEVANLDDSE FSGKGADNIKAFYHGHVGVTDQWIDLIDMKIAFLSSMSATLEDAKMSDAYIEESFLEH ELANAYAKSKSIMSEQKKAMKDILNNINDILPLEIFSTEDFKDKLSSADDKREKTIDK LNKLDEDLKTEYAETEPNEQFIQQDFKKLQESTGKGKNATPIHYNAKAYRESDIHKKK GDIEKHSEAYLSVKKEEAKEREIKELKKKLNDGVSDPDEYLEIAKKVGYENLEPTQVQ LAVQIEQAKQLEGAGEITWDIVKGVGVGLYDVGKDTVTGIWDFITDPGETLSALGNAA MHPVKTYDAISAAIEESYQKDMVNGDAYSRSRWVTYAIGSVAVAVVGTKGAGAINKAD AAGKVINKASQAGKKIKDVKIPDLLPYNPKYKLALADNVPYNVVDSQNLKNELLTNAK KIPDGTRKPFTGQKKSPPWLNKEKYDAYEIEGKVKAKGKVKDVSRRVYTMKDIDINQK TEFGVTNLQLMKNGNAPYAKDGTQINLHHLIQEEPGPMLEIPNSLHTKYSDVIHQLKS DGESFRNDKVLKAQYESFRKRYWKWRAKQFENEN*" /label="rttL CDS" gene complement(1912159..1913961) /gene="rttL" /locus_tag="BSU_19000" /old_locus_tag="BSU19000" /label="rttL gene" promotor_-10 complement(1913985..1914004) /Source="Nicolas_upshift_promotors" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" /label="promotor_-10" upshifts complement(1914001) /Source="Nicolas_upshifts" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" /label="upshifts" promotor_-35 complement(1914016..1914023) /Source="Nicolas_upshift_promotors" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" /label="promotor_-35" CDS complement(1914063..1914620) /gene="yobM" /locus_tag="Delta6_BSU_19010_SNPvariant" /old_locus_tag="BSU_19010" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="NP_389782.3" /db_xref="EnsemblGenomes-Gn:BSU19010" /db_xref="EnsemblGenomes-Tr:CAB13793" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG13505" /db_xref="UniProtKB/Swiss-Prot:O34377" /modified_by="User" /translation="MTNFVHKTVNGLKSLLDEKGAIQLFCSEGDIMEFLVTFSQDKAT LNDIQSFEAKHQLTLPQDYQKFMTLHNGAKIFEILSDGENIGGGLQLFSLEEIEEELK YEDLFEDINGIPIGYLLEECHLMIDKDKVNQGDPNYLYIFESGLEYNPLNLNFEKFLD RYILANGEPFWDWRYYTAENYYRTR*" /label="Delta6_BSU_19010_SNPvariant" gene complement(1914063..1914620) /gene="yobM" /locus_tag="Delta6_BSU_19010_SNPvariant" /old_locus_tag="BSU_19010" /modified_by="User" /label="Delta6_BSU_19010_SNPvariant" Polymorphism join(1914553,1914555) /Source="geneious" /ID="SNP_BsDelta6_2074149_2074149" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="K -> Q" /CDS_Position=67 /Change="T -> G" /Codon_Change="AAA -> CAA" /Coverage=154 /locus_tag="BSU_19010" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="Delta6_BSU_19010_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(1914627..1915022) /Source="Nicolas_S_feature" /locus_tag="new_2074222_2074617_c" /HighExp="M0t90, LoTm, M40t90, Lbstat, LBGstat, M9-stat, T0.30H, T2.30H, T1.0H, T2.0H" /AntisenseName="yobN" /AntisenseCor="-6.3634699133798794E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S722" promotor_-35 1914685..1914690 /Source="Nicolas_upshift_promotors" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" /label="promotor_-35" promotor_-10 1914706..1914724 /Source="Nicolas_upshift_promotors" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" /label="promotor_-10" upshifts 1914715 /Source="Nicolas_upshifts" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" /label="upshifts" S_feature 1914717..1914843 /Source="Nicolas_S_feature" /locus_tag="new_2074312_2074438" /HighExp="S3, S4, S5, S6, M9-stat, S8, S7, T5.0H, T4.0H, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S723" CDS 1914748..1916184 /gene="yobN" /locus_tag="BSU_19020" /old_locus_tag="BSU19020" /EC_number="1.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amine oxidase (flavoprotein)" /protein_id="NP_389783.2" /db_xref="EnsemblGenomes-Gn:BSU19020" /db_xref="EnsemblGenomes-Tr:CAB13794" /db_xref="GOA:O34363" /db_xref="InterPro:IPR001613" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13506" /db_xref="UniProtKB/Swiss-Prot:O34363" /translation="MNSLMNDDMVKIIRNGLSASQHPKHILVIGAGLSGLVSASLLKN AGHRVTILEASGRAGGRVCTLRSPFSDDLYFNAGPMRIPNNHSLTLEYIKKFKLPTNV FINRTPMDIIYANGIKTRLQVFERAPGILRYPVAPNEQGKTSEELMLSLLQPILNFIN QNPARNWRIVEEQYKNHSLSSFLNTYFSYGAIDMIGVLLDMEAYMGMSLVEVLRESIF FSSPAHFYEITGGMDLLPHAFLPQLKTNILYHQKMMKMSQGENRVTIHCQHQQTAEFT SFTADLAIVTIPFSTLRFVKVEPYHSFSYYKRRAIRELNYISATKIGIEFKSRFWEKA GQHGGKSITDLPIRFSYYPSRNIGANGHAVILASYTWADEALIWDSLSEGERIQYTLL NLSEIYGDIVWSEFVSGTSFSWSQYPYSAGGFTAFEPGQELELYPYIPVPEGRVHFAG EHASLTHAWMQGAIESGIRVAYEVNRLP*" /label="yobN CDS" gene 1914748..1916184 /gene="yobN" /locus_tag="BSU_19020" /old_locus_tag="BSU19020" /label="yobN gene" promotor_-10 complement(1915008..1915027) /Source="Nicolas_upshift_promotors" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1915022) /Source="Nicolas_upshifts" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1915041..1915047) /Source="Nicolas_upshift_promotors" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1916185..1916516 /Source="Nicolas_S_feature" /locus_tag="new_2075780_2076111" /HighExp="S3, S8, S4, S5, S7, M9-stat, S6, T5.0H, C30, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S724" promotor_-35 1916498..1916506 /Source="Nicolas_upshift_promotors" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1916517..1916535 /Source="Nicolas_upshift_promotors" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1916518..1916610 /Source="Nicolas_S_feature" /locus_tag="new_2076113_2076205" /HighExp="M9-stat, T1.30H, T2.0H, S2, T2.30H, Lbstat, BC, T0.30H, T3.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S725" upshifts 1916518 /Source="Nicolas_upshifts" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" /label="upshifts" CDS 1916611..1919031 /gene="yobO" /locus_tag="BSU_19030" /old_locus_tag="BSU19030" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11562162, 19450535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage-related pre-neck appendage protein; defective prophage 6" /protein_id="NP_389784.1" /db_xref="EnsemblGenomes-Gn:BSU19030" /db_xref="EnsemblGenomes-Tr:CAB13795" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR021865" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG13507" /db_xref="UniProtKB/Swiss-Prot:O34433" /translation="MVHFKNCPDPSLNANSQSHPEFSSELEHIKTRMQNFIKHSVTDQ NIEVTDARVTAEGEVTSLLKERLDKEYYRLLSKITREVNVADFGAVPDGRDNTEAFRK AIGNGRVKVHVPAGEYLVQGIKLPSWTTIVGQGKGITVIKLHEDTPAHEWVITNDDYQ NGNRNIFVQGMSLDWNPSRQCGVRNPGGQFSSCLTFAKVEYGWIKDVEAINAGLHGID ITSPTYDHLPDTDWTKDGSRYIWIDNCVTYGSGDDGITTHYSEYIFISNCHSGNPRGT EFAEGVSNSNGIEIDDGSRHVWLLNNFTSGNIRGVEVKAHELWPASQNVHIIGHISYR DVRAFDLRHIGHHQITDPESTTAYDVTLIDCSAVEPVFNSLYDAVTPRALVISAYKNV NVSGFTAIGDPDYDYKENPVVALQYRSQNITINGIKIRGFKKAGVDINLSGGSNKTDY IKISNFDIYKSAPKGISIGGGLYNVNILNGTMITDNGTVAIQSPNNQATILGVQSEGY SVAASIKGQTYQQVPINLKGGIQLATTSGFAVNQTSAVIAGTGDITARGERNAVISSS GGSSTEGSRALIASSNNAHIRGNQASRTILSSENIILEEPYTVAGGHQSIKWLLDSVR GNGTFAGAISSSLGGYGEYFESSTGQLIHTGTIVTLRGEKIVPANVGDYMLGVISETS AFISGASSFVWQGRYLTNEFGGFIYETVTDEESGELIRVPKQNPDYDTALEANYHSRA ARDEWHVVGLVGQHYVRIDETVNQGDYLTAHNGIGTKATEGSWKVMKITSAYTSEKGY GIALTVIK*" /label="yobO CDS" gene 1916611..1919031 /gene="yobO" /locus_tag="BSU_19030" /old_locus_tag="BSU19030" /label="yobO gene" S_feature complement(1918953..1919588) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" S_feature 1919032..1919489 /Source="Nicolas_S_feature" /locus_tag="new_2078627_2079084" /HighExp="M9-stat, Lbstat, BC, T1.30H, S2, T0.30H, T2.0H, T3.0H, T2.30H, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S727" promotor_-35 1919464..1919471 /Source="Nicolas_upshift_promotors" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1919483..1919502 /Source="Nicolas_upshift_promotors" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1919491..1919601 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" upshifts 1919491 /Source="Nicolas_upshifts" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1919501..1919608 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" /label="bsrF RNA" gene 1919501..1919608 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /label="bsrF gene" downshifts 1919586 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1919619..1919951) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" /label="csaA CDS" gene complement(1919619..1919951) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /label="csaA gene" downshifts complement(1919633) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1920016..1920741) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" /label="yobQ CDS" gene complement(1920016..1920741) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /label="yobQ gene" CDS complement(1920756..1921499) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" /label="yobR CDS" gene complement(1920756..1921499) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /label="yobR gene" promotor_-10 complement(1921527..1921546) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1921546) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1921560..1921566) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1921577..1922152) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" /label="yobS CDS" gene complement(1921577..1922152) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /label="yobS gene" CDS complement(1922158..1922859) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" /label="yobT CDS" gene complement(1922158..1922859) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /label="yobT gene" promotor_-10 complement(1922889..1922908) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1922889) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1922893..1922908) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1922923..1922930) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1922923..1922930) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1922933) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1922936..1923418) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" /label="yobU CDS" gene complement(1922936..1923418) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /label="yobU gene" misc_feature complement(1923457..1923474) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1923461) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1923472..1924413) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" /label="yobV CDS" gene complement(1923472..1924413) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /label="yobV gene" downshifts complement(1923505) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1924443..1924462) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1924451) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1924476..1924480) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1924484..1924493 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1924506..1924525 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1924514 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="upshifts" S_feature 1924529..1924593 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 1924565..1924570 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1924586..1924604 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1924595 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="upshifts" CDS 1924619..1925164 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" /label="yobW CDS" gene 1924619..1925164 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /label="yobW gene" downshifts 1925123 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS complement(1925191..1925514) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" /label="czrA CDS" gene complement(1925191..1925514) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /label="czrA gene" downshifts complement(1925198) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1925535..1925554) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1925546) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1925567..1925574) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1925635..1925641 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1925652 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1925656..1925675 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1925708..1926385 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" /label="yocA CDS" gene 1925708..1926385 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /label="yocA gene" downshifts 1926377 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1926475..1927011) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" /label="yozB CDS" gene complement(1926475..1927011) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /label="yozB gene" downshifts complement(1926498) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1927038..1927057) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1927058) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1927071..1927078) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1927148..1927930) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" /label="yocB CDS" gene complement(1927148..1927930) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /label="yocB gene" downshifts complement(1927157) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1927952..1927970) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1927971) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1927984..1927990) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1928027..1928034 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1928049..1928068 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1928053 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1928101..1928598 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" /label="yocC CDS" gene 1928101..1928598 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /label="yocC gene" promotor_-35 1928605..1928608 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1928624..1928643 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1928626 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1928662..1929639 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" /label="yocD CDS" gene 1928662..1929639 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /label="yocD gene" downshifts 1929611 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 1929736..1929743 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1929758..1929777 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1929765 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1929801..1930859 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" /label="desE CDS" gene 1929801..1930859 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /label="desE gene" S_feature 1930860..1930929 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 1930913..1930919 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1930931..1930950 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1930931 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1930979..1932091 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" /label="desK CDS" gene 1930979..1932091 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /label="desK gene" CDS 1932110..1932709 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" /label="desR CDS" gene 1932110..1932709 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /label="desR gene" downshifts 1932647 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1932691 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1932731..1933229) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(1932767) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1933201..1933210 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1933213..1933231) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1933222..1933416 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 1933222 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1933223..1933242 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1933229) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1933248..1933253) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1933304..1934167) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" /label="walL CDS" gene complement(1933304..1934167) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /label="walL gene" downshifts complement(1933317) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 1933373 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1933405) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" S_feature 1933418..1934185 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 1934163..1934167 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1934176..1934190 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1934187 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1934206..1934225) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1934219) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1934221..1934414) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(1934237..1934243) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1934415..1936190) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" /label="recQ CDS" gene complement(1934415..1936190) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /label="recQ gene" S_feature complement(1936191..1936321) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(1936314..1936516) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" /label="ssrSA RNA" gene complement(1936314..1936516) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /label="ssrSA gene" downshifts complement(1936366) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1936514..1936533) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(1936532) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="upshifts" S_feature complement(1936534..1936726) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(1936546..1936553) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(1936755..1937381) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" /label="azoJ CDS" gene complement(1936755..1937381) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /label="azoJ gene" downshifts complement(1936771) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1937415..1937434) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(1937428) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="upshifts" promotor_-35 complement(1937448..1937455) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(1937532..1938023) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" /label="yocK CDS" gene complement(1937532..1938023) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /label="yocK gene" downshifts complement(1937541) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1938035..1938053) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(1938047) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="upshifts" promotor_-35 complement(1938067..1938073) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(1938098..1938430) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" /label="yocL CDS" gene complement(1938098..1938430) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /label="yocL gene" S_feature complement(1938431..1938721) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 1938446..1938451 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 1938466..1938484 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 1938468 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="upshifts" CDS 1938508..1938735 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" /label="yoyB CDS" gene 1938508..1938735 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /label="yoyB gene" CDS complement(1938722..1939198) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" /label="yocM CDS" gene complement(1938722..1939198) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /label="yocM gene" S_feature 1938736..1939243 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(1939199..1939301) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 1939216..1939221 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1939236..1939254 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1939245 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="upshifts" CDS 1939265..1939528 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" /label="yozN CDS" gene 1939265..1939528 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /label="yozN gene" promotor_-10 complement(1939281..1939300) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1939301) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1939303..1939828) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(1939314..1939318) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1939533..1939766 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" /label="yocN CDS" gene 1939533..1939766 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /label="yocN gene" downshifts 1939753 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1939852..1940196) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" /label="yozO CDS" gene complement(1939852..1940196) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /label="yozO gene" downshifts complement(1939873) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" /label="downshifts" S_feature complement(1940197..1940269) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(1940265..1940284) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1940269) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1940271..1940374) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(1940298..1940303) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1940361..1940376) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1940374) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1940389..1940398) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1940517) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1940553..1940756) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" /label="yozC CDS" gene complement(1940553..1940756) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /label="yozC gene" promotor_-10 complement(1940777..1940796) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1940795) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1940797..1940863) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(1940812..1940819) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1940829..1940836 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 1940848 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="upshifts" misc_feature complement(1940850..1940862) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1940850..1940869 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 1940853..1940985 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(1940874) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="upshifts" CDS 1940986..1942473 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" /label="dhaS CDS" gene 1940986..1942473 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /label="dhaS gene" promotor_-10 complement(1941429..1941446) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1941435) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1941459..1941467) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1942459 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1942521..1942526 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1942542..1942560 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1942547 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="upshifts" CDS 1942574..1944472 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" /label="sqhC CDS" gene 1942574..1944472 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /label="sqhC gene" promotor_-10 complement(1943517..1943536) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1943525) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1943550..1943559) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1944462..1945307 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" /label="sodF CDS" gene 1944462..1945307 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /label="sodF gene" S_feature 1945308..1946814 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(1945340..1946677) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" /label="yocR CDS" gene complement(1945340..1946677) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /label="yocR gene" downshifts complement(1945351) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1946705..1946724) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1946720) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1946722..1947880) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(1946739..1946746) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1946798..1946801 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1946816..1946835 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1946816 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="upshifts" CDS 1946896..1947861 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" /label="yocS CDS" gene 1946896..1947861 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /label="yocS gene" downshifts 1947849 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1947911..1949164) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" /label="odhB CDS" gene complement(1947911..1949164) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /label="odhB gene" downshifts complement(1947925) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" CDS complement(1949180..1952014) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" /label="odhA CDS" gene complement(1949180..1952014) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /label="odhA gene" promotor_-10 complement(1952109..1952128) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1952124) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1952126..1952242) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(1952143..1952150) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1952243..1954159) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" /label="yojO CDS" gene complement(1952243..1954159) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /label="yojO gene" CDS complement(1954170..1955084) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" /label="yojN CDS" gene complement(1954170..1955084) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /label="yojN gene" promotor_-10 complement(1955088..1955107) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(1955103) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="upshifts" promotor_-35 complement(1955124..1955128) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(1955148..1955738) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" /label="sodC CDS" gene complement(1955148..1955738) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /label="sodC gene" CDS complement(1955831..1957075) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" /label="cwlS CDS" gene complement(1955831..1957075) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /label="cwlS gene" downshifts complement(1955833) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1957138..1957156) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1957151) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1957153..1957373) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(1957169..1957176) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1957359..1957377) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1957373) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1957389..1957397) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1957457..1958674) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" /label="yojK CDS" gene complement(1957457..1958674) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /label="yojK gene" downshifts complement(1957483) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1958707..1958726) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1958715) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1958740..1958747) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1958910..1959533) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" /label="cdaS CDS" gene complement(1958910..1959533) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /label="cdaS gene" S_feature complement(1959534..1959684) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 1959560..1959566 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1959572 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1959580..1959591 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1959598..1959606 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1959614..1959714 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 1959618..1959636 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1959629 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1959667..1959685) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1959674..1959759 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 1959674 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1959684) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1959701..1959707) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1959735..1959742 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1959755..1959774 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1959761 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="upshifts" CDS 1959799..1961157 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" /label="mdtK CDS" gene 1959799..1961157 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /label="mdtK gene" promotor_-10 complement(1960141..1960152) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1960146) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1960166..1960172) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1961173..1962021 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" /label="rsbRC CDS" gene 1961173..1962021 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /label="rsbRC gene" promotor_-10 complement(1961437..1961456) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1961444) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1961470..1961478) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1961984 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1962016) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1962047..1962712) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" /label="bshBB CDS" gene complement(1962047..1962712) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /label="bshBB gene" downshifts complement(1962061) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1962731..1963081) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" /label="yojF CDS" gene complement(1962731..1963081) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /label="yojF gene" CDS complement(1963078..1963356) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" /label="yoyC CDS" gene complement(1963078..1963356) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /label="yoyC gene" promotor_-10 complement(1963383..1963402) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1963399) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1963417..1963423) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1963432..1964328) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" /label="yojE CDS" gene complement(1963432..1964328) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /label="yojE gene" promotor_-35 1964170..1964179 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1964190 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1964193..1964212 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1964208..1964426 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(1964352..1964371) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1964372) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1964383..1964390) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1964427..1964900 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" /label="gerT CDS" gene 1964427..1964900 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /label="gerT gene" downshifts 1964897 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1964935..1965171) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" /label="yojB CDS" gene complement(1964935..1965171) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /label="yojB gene" downshifts complement(1964943) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1965194..1965213) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1965209) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1965227..1965236) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1965256..1966590) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" /label="yojA CDS" gene complement(1965256..1966590) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /label="yojA gene" S_feature complement(1966591..1966726) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(1966723..1966742) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1966733) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1966757..1966764) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1966822..1966829 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1966844..1966863 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1966847 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1966848..1966954 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 1966955..1967344 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" /label="yodA CDS" gene 1966955..1967344 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /label="yodA gene" downshifts 1967354 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1967751..1968089) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" /label="arxR CDS" gene complement(1967751..1968089) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /label="arxR gene" promotor_-35 1968112..1968119 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1968133..1968152 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1968142 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="upshifts" S_feature 1968146..1968218 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(1968177..1968196) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1968180) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1968208..1968214) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1968219..1968827 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" /label="noxC CDS" gene 1968219..1968827 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /label="noxC gene" downshifts 1968817 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1968870..1969472) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" /label="yodD CDS" gene complement(1968870..1969472) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /label="yodD gene" CDS complement(1969488..1970399) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" /label="yodE CDS" gene complement(1969488..1970399) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /label="yodE gene" promotor_-10 complement(1970428..1970447) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1970444) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1970463..1970468) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1970520..1970523 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1970538..1970557 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1970540 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="upshifts" CDS 1970583..1970783 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" /label="yoyD CDS" gene 1970583..1970783 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /label="yoyD gene" CDS 1970783..1972273 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" /label="yodF CDS" gene 1970783..1972273 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /label="yodF gene" promotor_-10 complement(1971518..1971529) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1971522) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1971543..1971549) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1972261 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1972308..1973708) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" /label="ctpA CDS" gene complement(1972308..1973708) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /label="ctpA gene" downshifts complement(1972332) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-35 1973479..1973488 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1973500..1973515 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1973514 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1973728..1973747) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1973748) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1973761..1973768) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1973807..1973816 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1973822 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1973829..1973848 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1973861..1974562 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" /label="yodH CDS" gene 1973861..1974562 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /label="yodH gene" promotor_-35 1974587..1974595 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1974609..1974628 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1974614 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="upshifts" CDS 1974650..1974901 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" /label="yodI CDS" gene 1974650..1974901 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /label="yodI gene" downshifts 1974922 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1974972..1975793) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" /label="ldcB CDS" gene complement(1974972..1975793) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /label="ldcB gene" downshifts complement(1974998) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1975794..1975875) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(1975876..1976577) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" /label="deoD CDS" gene complement(1975876..1976577) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /label="deoD gene" S_feature complement(1976578..1976667) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(1976652..1976671) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1976667) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1976687..1976691) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1976725..1976731 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1976746..1976757 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1976763 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="upshifts" CDS 1976779..1976904 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" /label="yoyE CDS" gene 1976779..1976904 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /label="yoyE gene" downshifts 1976902 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1976944..1977258) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" /label="yodL CDS" gene complement(1976944..1977258) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /label="yodL gene" downshifts complement(1976956) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1977279..1977297) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1977286) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1977308..1977316) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1977319..1977930) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" /label="pgpB CDS" gene complement(1977319..1977930) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /label="pgpB gene" CDS complement(1978008..1978184) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" /label="yozD CDS" gene complement(1978008..1978184) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /label="yozD gene" downshifts complement(1978012) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1978023) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1978027..1978046) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1978062..1978065) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1978198..1978216) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(1978219) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="upshifts" S_feature complement(1978221..1978442) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(1978232..1978237) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 1978242..1978247 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1978262..1978280 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1978264 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="upshifts" CDS 1978303..1978446 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" /label="yoyF CDS" gene 1978303..1978446 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /label="yoyF gene" CDS complement(1978443..1979123) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" /label="yodN CDS" gene complement(1978443..1979123) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /label="yodN gene" S_feature 1978447..1979458 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(1979150..1979169) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1979156) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1979183..1979192) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1979274..1979498) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" /label="yozE CDS" gene complement(1979274..1979498) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /label="yozE gene" downshifts complement(1979288) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1979539..1979558) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1979551) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1979585..1979863) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" /label="yokU CDS" gene complement(1979585..1979863) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /label="yokU gene" CDS complement(1979860..1981275) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" /label="kamA CDS" gene complement(1979860..1981275) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /label="kamA gene" promotor_-35 1980531..1980534 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1980550..1980569 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1980555 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1981304..1982131) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " /label="kamB CDS" gene complement(1981304..1982131) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /label="kamB gene" CDS complement(1982109..1983419) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" /label="yodQ CDS" gene complement(1982109..1983419) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /label="yodQ gene" CDS complement(1983428..1984081) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " /label="yodR CDS" gene complement(1983428..1984081) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /label="yodR gene" CDS complement(1984066..1984755) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" /label="yodS CDS" gene complement(1984066..1984755) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /label="yodS gene" CDS complement(1984762..1986096) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" /label="yodT CDS" gene complement(1984762..1986096) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /label="yodT gene" CDS complement(1986077..1986232) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" /label="conserved hypothetical protein CDS" gene complement(1986077..1986232) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /label="gene" promotor_-10 complement(1986115..1986133) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1986131) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1986149..1986154) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1986226..1986459) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" /label="yoyG CDS" gene complement(1986226..1986459) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /label="yoyG gene" downshifts complement(1986233) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 1986335..1986339 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1986348..1986362 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1986363 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1986364..1986383) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1986373) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1986398..1986407) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1986419..1987198) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" /label="cgeE CDS" gene complement(1986419..1987198) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /label="cgeE gene" CDS complement(1987227..1988507) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" /label="cgeD CDS" gene complement(1987227..1988507) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /label="cgeD gene" promotor_-10 complement(1987875..1987893) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1987891) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1987907..1987914) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1988475..1988493) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1988485) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1988509..1988514) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1988572..1988877) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " /label="cgeC CDS" gene complement(1988572..1988877) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /label="cgeC gene" downshifts complement(1988705) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1988901..1988920) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(1988916) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="upshifts" promotor_-35 complement(1988934..1988943) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 1989013..1989022 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1989036..1989055 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1989036 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1989057) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1989059..1989073) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1989082..1989086) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1989082..1989483 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" /label="cgeA CDS" gene 1989082..1989483 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /label="cgeA gene" CDS 1989490..1990443 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" /label="cgeB CDS" gene 1989490..1990443 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /label="cgeB gene" downshifts 1990433 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1990514..1991662) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" /label="phyC CDS" gene complement(1990514..1991662) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /label="phyC gene" downshifts complement(1990531) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" promotor_-35 1991675..1991679 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1991688..1991707) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1991695..1991714 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1991697) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 1991705 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1991966..1991974 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1991988..1992007 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1991991 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="upshifts" CDS 1992032..1993057 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 1992032..1993057 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 1992435 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 <1992437..1992441 /Source="Nicolas_upshift_promotors" /id="U1702" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1418 /SigmaFactorBS="tttcatttttgacctcacagccactaATAGTTTCCActaaga aaagtagTAAGTATCTTAAAAAACAGAtaaagctgtatctcctgtgaacacaatgggt g" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" SCAR 1992451..1992452 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 1993049 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1993101..1993532) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" /label="msrB CDS" gene complement(1993101..1993532) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /label="msrB gene" downshifts complement(1993106) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1993533..1994066) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" /label="msrA CDS" gene complement(1993533..1994066) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /label="msrA gene" promotor_-35 1994070..1994076 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1994087..1994197 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 1994087 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1994089..1994108 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1994094..1994113) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1994114) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1994129..1994130) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1994198..1994623 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" /label="ypoP CDS" gene 1994198..1994623 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /label="ypoP gene" downshifts 1994611 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 1994656..1995887 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(1994673..1996010) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" /label="dinF CDS" gene complement(1994673..1996010) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /label="dinF gene" CDS complement(1996082..1996276) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" /label="ypmT CDS" gene complement(1996082..1996276) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /label="ypmT gene" downshifts complement(1996095) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1996289..1996852) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" /label="ypmS CDS" gene complement(1996289..1996852) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /label="ypmS gene" CDS complement(1996862..1997629) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" /label="ypmR CDS" gene complement(1996862..1997629) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /label="ypmR gene" promotor_-10 complement(1997653..1997672) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1997670) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1997683..1997690) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1997707..1998288) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" /label="scuA CDS" gene complement(1997707..1998288) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /label="scuA gene" S_feature complement(1998289..1998404) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(1998436..1998687) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" /label="ypmP CDS" gene complement(1998436..1998687) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /label="ypmP gene" downshifts complement(1998449) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1998710..1998729) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1998724) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1998773..2000041) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" /label="ilvA CDS" gene complement(1998773..2000041) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /label="ilvA gene" promotor_-10 complement(2000075..2000094) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2000094) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2000106..2000113) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2000248..2000267 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2000251 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="upshifts" CDS 2000290..2001285 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" /label="silP CDS" gene 2000290..2001285 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /label="silP gene" CDS 2001306..2001947 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" /label="yplQ CDS" gene 2001306..2001947 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /label="yplQ gene" S_feature 2001948..2003049 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(2001986..2002606) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" /label="ypkP CDS" gene complement(2001986..2002606) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /label="ypkP gene" downshifts complement(2002012) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(2002607..2003113) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" /label="dfrA CDS" gene complement(2002607..2003113) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /label="dfrA gene" CDS complement(2003110..2003904) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" /label="thyB CDS" gene complement(2003110..2003904) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /label="thyB gene" CDS complement(2003988..2004521) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" /label="ypjQ CDS" gene complement(2003988..2004521) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /label="ypjQ gene" downshifts complement(2003993) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" /label="downshifts" promotor_-35 2004451..2004456 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2004467..2005413 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 2004469 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2004473..2004491 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2004539..2005150) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" /label="ypjP CDS" gene complement(2004539..2005150) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /label="ypjP gene" promotor_-10 complement(2005182..2005201) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2005201) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2005214..2005219) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2005370 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" /label="downshifts" CDS complement(2005410..2006183) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" /label="rsmJ CDS" gene complement(2005410..2006183) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /label="rsmJ gene" downshifts complement(2005445) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2006225..2006659) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" /label="brxA CDS" gene complement(2006225..2006659) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /label="brxA gene" downshifts complement(2006237) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2006688..2006707) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(2006699) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="upshifts" S_feature complement(2006701..2006765) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(2006721..2006728) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(2006744) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2006766..2008442) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" /label="ilvD CDS" gene complement(2006766..2008442) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /label="ilvD gene" S_feature complement(2008443..2008633) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(2008622..2008641) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2008633) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2008656..2008659) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2008731..2009864) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" /label="ypgR CDS" gene complement(2008731..2009864) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /label="ypgR gene" downshifts complement(2008747) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature complement(2009886..2009905) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2009889) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2009924..2010541) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" /label="hdhQ CDS" gene complement(2009924..2010541) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /label="hdhQ gene" CDS complement(2010557..2011039) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" /label="bsaA CDS" gene complement(2010557..2011039) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /label="bsaA gene" S_feature complement(2011040..2011187) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(2011178..2011196) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(2011188) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="upshifts" promotor_-35 complement(2011207..2011215) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 2011241..2011250 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 2011263..2011278 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 2011265..2011351 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 2011265 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" promotor_-35 2011314..2011321 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 2011336..2011355 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 2011353 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" CDS 2011382..2012287 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" /label="metAA CDS" gene 2011382..2012287 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /label="metAA gene" misc_feature 2012322..2012341 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2012336 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" S_feature 2012337..2012517 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 2012518..2013666 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" /label="ugtP CDS" gene 2012518..2013666 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /label="ugtP gene" S_feature complement(2012687..2013716) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 2013662 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2013698..2013717) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2013716) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2013732..2013740) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2013747..2013893 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" /label="hypothetical protein CDS" gene 2013747..2013893 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /label="gene" promotor_-35 2013786..2013793 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2013807..2013826 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2013818..2013908 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 2013818 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 2013909..2014109 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" /label="cspD CDS" gene 2013909..2014109 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /label="cspD gene" downshifts 2014124 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS complement(2014161..2014343) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" /label="degR CDS" gene complement(2014161..2014343) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /label="degR gene" S_feature 2014169..2014474 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(2014178) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2014404..2014422) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2014436..2014442) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2014440) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2014450..2014456 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2014471..2014482 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2014476 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 2014499..2014768 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" /label="ypzA CDS" gene 2014499..2014768 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /label="ypzA gene" downshifts 2014623 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" /label="downshifts" downshifts 2014751 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(2014796..2014978) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" /label="ypeQ CDS" gene complement(2014796..2014978) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /label="ypeQ gene" downshifts complement(2014816) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2014971..2015651) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" /label="ypeP CDS" gene complement(2014971..2015651) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /label="ypeP gene" S_feature complement(2015652..2015789) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 2015668..2015673 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2015686..2015705 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2015691 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 2015734..2016423 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" /label="queP CDS" gene 2015734..2016423 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /label="queP gene" promotor_-35 complement(2015787..2015803) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2015790) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2015791..2016180) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(2016161..2016180) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2016178) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2016192..2016200) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2016423..2016821 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" /label="ypdQ CDS" gene 2016423..2016821 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /label="ypdQ gene" promotor_-35 2016814..2016820 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2016835..2016846 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2016846 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 2016863..2016991 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" /label="sspL CDS" gene 2016863..2016991 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /label="sspL gene" S_feature 2016992..2017972 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(2016999..2017889) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" /label="exnP CDS" gene complement(2016999..2017889) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /label="exnP gene" downshifts complement(2017036) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2017911..2017930) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2017918) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2017942..2017948) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2017946 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2017990..2018136) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" /label="ypzF CDS" gene complement(2017990..2018136) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /label="ypzF gene" downshifts complement(2018006) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2018160) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2018161..2018172) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2018187..2018193) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2018211..2018468) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" /label="ypbS CDS" gene complement(2018211..2018468) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /label="ypbS gene" promotor_-10 complement(2018488..2018507) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2018503) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2018519..2018526) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2018533..2022114) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" /label="dynA CDS" gene complement(2018533..2022114) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /label="dynA gene" S_feature complement(2022115..2022186) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(2022176..2022195) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2022186) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="upshifts" S_feature complement(2022231..2022428) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(2022274) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2022290..2022379) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" /label="fbpC CDS" gene complement(2022290..2022379) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /label="fbpC gene" promotor_-10 complement(2022407..2022426) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2022428) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2022441..2022448) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2022450..2022956) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" /label="bpsB CDS" gene complement(2022450..2022956) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /label="bpsB gene" CDS complement(2022960..2024057) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" /label="bpsA CDS" gene complement(2022960..2024057) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /label="bpsA gene" promotor_-10 complement(2024075..2024086) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2024078) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2024101..2024107) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2024131..2025447) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" /label="pbuX CDS" gene complement(2024131..2025447) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /label="pbuX gene" downshifts complement(2024144) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2025444..2026028) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" /label="xpt CDS" gene complement(2025444..2026028) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /label="xpt gene" misc_RNA complement(2026117..2026217) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswA RNA" gene complement(2026117..2026217) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /label="gswA gene" downshifts complement(2026124) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" S_feature complement(2026218..2026358) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(2026359..2027864) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" /label="ypwA CDS" gene complement(2026359..2027864) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /label="ypwA gene" promotor_no_box complement(2027800..2027900) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2027840) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" downshifts 2027852 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2027890..2027909) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2027906) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2027923..2027930) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2027976..2028968) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" /label="kdgT CDS" gene complement(2027976..2028968) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /label="kdgT gene" downshifts complement(2027994) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2029013..2029603) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" /label="kdgA CDS" gene complement(2029013..2029603) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /label="kdgA gene" CDS complement(2029605..2030579) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" /label="kdgK CDS" gene complement(2029605..2030579) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /label="kdgK gene" CDS complement(2030617..2031636) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" /label="kdgR CDS" gene complement(2030617..2031636) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /label="kdgR gene" promotor_-10 complement(2031684..2031703) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2031694) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2031715..2031722) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2031757..2031764 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2031778..2031857 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 2031778 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2031779..2031798 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2031858..2032685 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " /label="kduI CDS" gene 2031858..2032685 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /label="kduI gene" CDS 2032687..2033451 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" /label="kduD CDS" gene 2032687..2033451 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /label="kduD gene" downshifts 2033440 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2033482) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2033492..2035417) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" /label="ypvA CDS" gene complement(2033492..2035417) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /label="ypvA gene" promotor_-10 complement(2035448..2035467) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2035452) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2035454..2035518) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(2035482..2035486) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2035519..2035710) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" /label="yptA CDS" gene complement(2035519..2035710) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /label="yptA gene" promotor_-10 complement(2035729..2035747) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2035738) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2035740..2036045) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(2035763..2035768) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2035777..2035783 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2035798..2035809 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2035807 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="upshifts" CDS 2035874..2036026 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" /label="ypzG CDS" gene 2035874..2036026 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /label="ypzG gene" downshifts 2036036 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2036079..2037236) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" /label="rlmKB CDS" gene complement(2036079..2037236) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /label="rlmKB gene" downshifts complement(2036090) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2037324..2037724) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rnpB RNA" gene complement(2037324..2037724) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /label="rnpB gene" downshifts complement(2037334) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2037721..2037740) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2037739) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2037755..2037761) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2037783..2038079) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" /label="gpsB CDS" gene complement(2037783..2038079) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /label="gpsB gene" promotor_-10 complement(2038104..2038123) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2038114) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(2038137..2038144) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2038157..2038786) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" /label="ypsA CDS" gene complement(2038157..2038786) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /label="ypsA gene" downshifts complement(2038752) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2038788..2039015) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" /label="cotD CDS" gene complement(2038788..2039015) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /label="cotD gene" promotor_-10 complement(2039043..2039062) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(2039058) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="upshifts" S_feature complement(2039060..2039214) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(2039076..2039084) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(2039099..2039227) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" /label="conserved protein of unknown function CDS" gene complement(2039099..2039227) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /label="gene" upshifts complement(2039214) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" S_feature complement(2039216..2039327) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(2039217..2039236) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(2039252..2039256) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2039328..2040569) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" /label="yprB CDS" gene complement(2039328..2040569) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /label="yprB gene" promotor_-10 complement(2040283..2040301) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(2040292) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="upshifts" promotor_-35 complement(2040316..2040323) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(2040585..2042834) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" /label="yprA CDS" gene complement(2040585..2042834) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /label="yprA gene" promotor_-10 complement(2042850..2042869) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2042866) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(2042883..2042889) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2042937..2043443) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" /label="ypqE CDS" gene complement(2042937..2043443) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /label="ypqE gene" downshifts complement(2042960) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2043487..2043506) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2043504) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(2043520..2043527) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 2043525..2043534 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2043548..2043567 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2043560 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="upshifts" CDS 2043581..2044000 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" /label="ypqA CDS" gene 2043581..2044000 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /label="ypqA gene" S_feature 2044001..2044151 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(2044021..2044398) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" /label="yppG CDS" gene complement(2044021..2044398) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /label="yppG gene" downshifts complement(2044054) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature 2044396..2044541 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(2044428..2044446) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2044447) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2044460..2044469) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2044542..2044561 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2044543 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="upshifts" CDS 2044586..2044774 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" /label="yppF CDS" gene 2044586..2044774 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /label="yppF gene" downshifts 2044790 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" CDS complement(2044813..2045184) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" /label="yppE CDS" gene complement(2044813..2045184) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /label="yppE gene" downshifts complement(2044846) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2045196..2045215) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2045209) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2045228..2045233) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2045230..2045475) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" /label="yppD CDS" gene complement(2045230..2045475) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /label="yppD gene" promotor_-10 complement(2045501..2045519) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2045506) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2045531..2045539) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2045625..2045631 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2045646..2045657 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2045653 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="upshifts" CDS 2045674..2045778 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" /label="sspM CDS" gene 2045674..2045778 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /label="sspM gene" downshifts 2045760 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2045803..2046765) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" /label="yppC CDS" gene complement(2045803..2046765) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /label="yppC gene" promotor_-35 2045933..2045942 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2045954..2045969 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2045954 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2045958..2046293 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 2046264..2046268 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2046284..2046303 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2046295..2046805 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 2046295 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2046766..2047222) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 2046806..2047426 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" /label="recU CDS" gene 2046806..2047426 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /label="recU gene" promotor_-10 complement(2047211..2047222) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2047222) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2047237..2047243) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2047448..2050192 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" /label="ponA CDS" gene 2047448..2050192 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /label="ponA gene" downshifts complement(2049862) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" /label="downshifts" downshifts 2050178 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2050268..2050762) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" /label="ypoC CDS" gene complement(2050268..2050762) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /label="ypoC gene" downshifts complement(2050281) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2050759..2051418) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" /label="nth CDS" gene complement(2050759..2051418) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /label="nth gene" CDS complement(2051437..2052135) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" /label="dnaD CDS" gene complement(2051437..2052135) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /label="dnaD gene" S_feature complement(2052136..2052227) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(2052228..2053520) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" /label="asnS CDS" gene complement(2052228..2053520) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /label="asnS gene" S_feature complement(2053521..2053582) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(2053582..2053601) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2053582) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2053616..2053623) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2053664..2054845) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" /label="aspB CDS" gene complement(2053664..2054845) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /label="aspB gene" downshifts complement(2053668) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2054868..2055353) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" /label="tseB CDS" gene complement(2054868..2055353) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /label="tseB gene" promotor_-10 complement(2055301..2055320) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2055318) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2055333..2055340) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2055362..2055532) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" /label="ypmA CDS" gene complement(2055362..2055532) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /label="ypmA gene" S_feature complement(2055533..2055604) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 2055566..2055572 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2055587..2055606) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2055587..2055598 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2055594..2055668 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 2055594 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2055604) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2055606..2055674) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(2055622..2055628) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2055638 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2055675..2058470) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" /label="dinG CDS" gene complement(2055675..2058470) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /label="dinG gene" promotor_-35 2056143..2056147 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2056144 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2056149..2056153 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2056800..2056815) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(2056814) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(2056828..2056837) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(2058471..2058595) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(2058596..2058979) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" /label="panD CDS" gene complement(2058596..2058979) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /label="panD gene" CDS complement(2058981..2059841) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" /label="panC CDS" gene complement(2058981..2059841) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /label="panC gene" CDS complement(2059843..2060676) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" /label="panB CDS" gene complement(2059843..2060676) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /label="panB gene" S_feature complement(2060677..2060884) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(2060879..2060898) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2060884) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2060915..2060919) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2060922..2061899) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" /label="birA CDS" gene complement(2060922..2061899) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /label="birA gene" CDS complement(2061884..2063077) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" /label="cca CDS" gene complement(2061884..2063077) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /label="cca gene" CDS complement(2063082..2064215) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" /label="bshA CDS" gene complement(2063082..2064215) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /label="bshA gene" CDS complement(2064212..2064922) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" /label="bshBA CDS" gene complement(2064212..2064922) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /label="bshBA gene" CDS complement(2064915..2065328) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" /label="mgsA CDS" gene complement(2064915..2065328) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /label="mgsA gene" CDS complement(2065344..2066147) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" /label="dapB CDS" gene complement(2065344..2066147) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /label="dapB gene" CDS complement(2066159..2066494) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" /label="ypjD CDS" gene complement(2066159..2066494) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /label="ypjD gene" promotor_-10 complement(2066514..2066533) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(2066524) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(2066547..2066554) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 2066563..2066570 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2066579..2066598) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 2066584..2066603 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2066590 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2066598) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" CDS 2066634..2067506 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" /label="ypjC CDS" gene 2066634..2067506 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /label="ypjC gene" CDS complement(2067548..2068342) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" /label="ypjB CDS" gene complement(2067548..2068342) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /label="ypjB gene" downshifts complement(2067573) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" /label="downshifts" S_feature complement(2068343..2068410) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(2068411..2068968) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" /label="ypjA CDS" gene complement(2068411..2068968) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /label="ypjA gene" S_feature complement(2068969..2069048) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(2069093) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2069115..2069882) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" /label="qcrC CDS" gene complement(2069115..2069882) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /label="qcrC gene" CDS complement(2069917..2070591) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" /label="qcrB CDS" gene complement(2069917..2070591) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /label="qcrB gene" CDS complement(2070593..2071096) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" /label="qcrA CDS" gene complement(2070593..2071096) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /label="qcrA gene" downshifts 2071105 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2071160..2071179) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2071160) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2071194..2071201) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2071239..2071685) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" /label="ypiF CDS" gene complement(2071239..2071685) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /label="ypiF gene" downshifts 2071688 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" /label="downshifts" CDS complement(2071740..2072279) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" /label="ypiB CDS" gene complement(2071740..2072279) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /label="ypiB gene" downshifts complement(2071753) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2072312..2072330) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(2072323) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="upshifts" promotor_-35 complement(2072342..2072350) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(2072351..2073622) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" /label="ypiA CDS" gene complement(2072351..2073622) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /label="ypiA gene" S_feature complement(2073623..2073690) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(2073687..2073706) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2073690) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2073720..2073727) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2073757..2073776) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(2073763) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="upshifts" S_feature complement(2073765..2073909) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(2073787..2073794) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(2073891..2073909) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(2073909) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(2073925..2073930) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(2073958..2075244) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" /label="aroA CDS" gene complement(2073958..2075244) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /label="aroA gene" downshifts complement(2073981) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2075255..2076370) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" /label="tyrA CDS" gene complement(2075255..2076370) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /label="tyrA gene" CDS complement(2076419..2077501) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" /label="hisC CDS" gene complement(2076419..2077501) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /label="hisC gene" CDS complement(2077512..2078315) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" /label="trpA CDS" gene complement(2077512..2078315) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /label="trpA gene" promotor_-10 complement(2078000..2078019) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(2078017) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(2078031..2078038) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(2078308..2079510) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" /label="trpB CDS" gene complement(2078308..2079510) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /label="trpB gene" CDS complement(2079491..2080138) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" /label="trpF CDS" gene complement(2079491..2080138) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /label="trpF gene" downshifts complement(2079585) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" /label="downshifts" misc_feature complement(2079761..2079764) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2079761) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" downshifts complement(2079981) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" /label="downshifts" gene complement(2080143..2080892) /gene="trpC" /locus_tag="BSU_22660" /old_locus_tag="BSU22660" /pseudo /label="trpC gene" CDS complement(2080143..2080892) /gene="trpC" /locus_tag="BSU_22660" /old_locus_tag="BSU22660" /EC_number="4.1.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10627030, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10627030, 10714985, 12963367, 17114058; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /db_xref="GOA:P03964" /db_xref="InterPro:IPR001468" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013798" /db_xref="PSEUDO:CAB14182.3" /db_xref="SubtiList:BG11038" /db_xref="UniProtKB/Swiss-Prot:P03964" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASPNRFIGLIA EVKKASPSKGLIKEDFVPVQIAKDYEAAKADAISVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKGMDVLVEVHDAS TLEQILKVFTPDILGVNNRNLKTFETSVKQTEQIASLVPKESLLVSESGIGSLEHLTF VNEHGARAVLIGESLMRQTSQRKAIHALFRE*" /label="trpC CDS" misc_feature complement(2080176..2080178) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2080179) /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" CDS complement(2080885..2081901) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /modified_by="User" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" /label="trpD CDS" gene complement(2080885..2081901) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /modified_by="User" /label="trpD gene" CDS complement(2081873..2083420) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" /label="trpE CDS" gene complement(2081873..2083420) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /label="trpE gene" S_feature complement(2083499..2083630) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(2083542) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2083621..2083640) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(2083630) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" CDS complement(2083636..2084019) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" /label="aroH CDS" gene complement(2083636..2084019) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /label="aroH gene" promotor_-35 complement(2083655..2083662) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(2084016..2085104) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" /label="aroB CDS" gene complement(2084016..2085104) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /label="aroB gene" promotor_-10 complement(2084145..2084160) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(2084158) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(2084173..2084181) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(2085104..2086276) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" /label="aroF CDS" gene complement(2085104..2086276) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /label="aroF gene" promotor_-10 complement(2086311..2086330) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2086328) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(2086343..2086350) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2086351..2087121) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" /label="cheR CDS" gene complement(2086351..2087121) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /label="cheR gene" promotor_-10 complement(2087147..2087166) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2087164) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(2087178..2087184) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(2087196..2087357) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(2087239) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" CDS complement(2087358..2087807) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" /label="ndk CDS" gene complement(2087358..2087807) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /label="ndk gene" promotor_-10 complement(2087850..2087869) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(2087857) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(2087882..2087889) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(2087923..2088969) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" /label="hepT CDS" gene complement(2087923..2088969) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /label="hepT gene" CDS complement(2088911..2089612) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" /label="menG CDS" gene complement(2088911..2089612) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /label="menG gene" CDS complement(2089619..2090374) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" /label="hepS CDS" gene complement(2089619..2090374) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /label="hepS gene" S_feature complement(2090375..2090460) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(2090449..2090468) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2090460) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(2090479..2090486) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2090538..2090765) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" /label="mtrB CDS" gene complement(2090538..2090765) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /label="mtrB gene" downshifts complement(2090559) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" /label="downshifts" CDS complement(2090787..2091359) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" /label="folEA CDS" gene complement(2090787..2091359) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /label="folEA gene" promotor_-10 complement(2091388..2091407) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2091398) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" S_feature complement(2091400..2091483) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(2091420..2091426) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(2091528) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" /label="downshifts" CDS complement(2091547..2091825) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" /label="hbs CDS" gene complement(2091547..2091825) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /label="hbs gene" S_feature complement(2091826..2092051) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(2092033..2092052) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2092051) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(2092069..2092074) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2092199..2093677) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" /label="spoIVA CDS" gene complement(2092199..2093677) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /label="spoIVA gene" downshifts complement(2092212) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2093678..2093839) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(2093826..2093844) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(2093851) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="upshifts" CDS complement(2093858..2094592) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" /label="yphF CDS" gene complement(2093858..2094592) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /label="yphF gene" promotor_-35 complement(2093859..2093864) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(2093884) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" /label="downshifts" CDS complement(2094614..2094817) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" /label="yphE CDS" gene complement(2094614..2094817) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /label="yphE gene" promotor_-10 complement(2094853..2094872) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2094874) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2094886..2094893) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2094939..2095138) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(2094982) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2095113..2095132) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2095138) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2095146..2095155) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2095155..2096192) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" /label="gpsA CDS" gene complement(2095155..2096192) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /label="gpsA gene" CDS complement(2096210..2097520) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" /label="der CDS" gene complement(2096210..2097520) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /label="der gene" S_feature complement(2097521..2097645) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(2097631..2097650) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2097645) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2097665..2097668) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2097674..2097868) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" /label="ypzH CDS" gene complement(2097674..2097868) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /label="ypzH gene" CDS complement(2097865..2098758) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" /label="yphB CDS" gene complement(2097865..2098758) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /label="yphB gene" CDS complement(2098755..2099354) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" /label="yphA CDS" gene complement(2098755..2099354) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /label="yphA gene" promotor_-35 2099227..2099233 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2099242..2099425 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 2099244 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2099247..2099258 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2099365..2099383) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2099384) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2099399..2099404) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2099432..2099563 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " /label="ypzI CDS" gene 2099432..2099563 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /label="ypzI gene" downshifts 2099551 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2099606..2100655) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" /label="fni CDS" gene complement(2099606..2100655) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /label="fni gene" downshifts complement(2099626) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2100530) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" /label="downshifts" CDS complement(2100668..2101816) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" /label="rpfA CDS" gene complement(2100668..2101816) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /label="rpfA gene" misc_feature 2100997..2101000 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2101024 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2101090 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2101794 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" /label="downshifts" S_feature complement(2101817..2101956) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(2101955..2101974) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2101956) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2101958..2102048) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(2101989..2101996) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2102049..2102723) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" /label="cmk CDS" gene complement(2102049..2102723) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /label="cmk gene" S_feature complement(2102724..2102801) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(2102802..2102978) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" /label="ypfB CDS" gene complement(2102802..2102978) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /label="ypfB gene" promotor_-10 complement(2102990..2103008) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2103007) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2103023..2103029) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2103023..2103676) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " /label="dgrA CDS" gene complement(2103023..2103676) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /label="dgrA gene" promotor_-10 complement(2103706..2103725) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2103719) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2103741..2103745) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2103769..2105121) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" /label="sleC CDS" gene complement(2103769..2105121) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /label="sleC gene" downshifts complement(2103784) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2105156..2106073) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" /label="sleB CDS" gene complement(2105156..2106073) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /label="sleB gene" downshifts complement(2105544) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" /label="downshifts" misc_feature complement(2105695..2105702) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2105698) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2106111..2106122) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2106120) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2106136..2106142) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2106212..2106868) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" /label="prsW CDS" gene complement(2106212..2106868) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /label="prsW gene" downshifts complement(2106226) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2106893..2106912) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2106908) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2106988..2107962) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" /label="ypdA CDS" gene complement(2106988..2107962) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /label="ypdA gene" downshifts complement(2106996) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-35 2107816..2107821 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2107837..2107855 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2107847..2108040 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 2107847 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="upshifts" downshifts 2107998 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2108071..2109354) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" /label="gudB CDS" gene complement(2108071..2109354) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /label="gudB gene" downshifts complement(2108074) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" /label="downshifts" promotor_-35 2108112..2108118 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2108130..2108134 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2108130 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2109397..2109416) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2109418) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2109431..2109438) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2109510..2110094) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" /label="mecB CDS" gene complement(2109510..2110094) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /label="mecB gene" downshifts complement(2109512) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" /label="downshifts" S_feature complement(2110095..2110176) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(2110169..2110188) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(2110176) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="upshifts" promotor_-35 complement(2110202..2110209) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(2110253..2111032) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" /label="ypbG CDS" gene complement(2110253..2111032) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /label="ypbG gene" promotor_-10 complement(2111058..2111073) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(2111069) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="upshifts" promotor_-35 complement(2111085..2111094) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(2111118..2111561) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" /label="ypbF CDS" gene complement(2111118..2111561) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /label="ypbF gene" downshifts complement(2111135) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2111624..2112346) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" /label="ypbE CDS" gene complement(2111624..2112346) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /label="ypbE gene" downshifts complement(2111905) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" CDS complement(2112297..2112866) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" /label="ypbD CDS" gene complement(2112297..2112866) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /label="ypbD gene" promotor_-10 complement(2112615..2112633) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2112631) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2112648..2112654) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2112885..2113631 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(2112926..2114416) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" /label="recS CDS" gene complement(2112926..2114416) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /label="recS gene" CDS complement(2114409..2115467) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" /label="gmmB CDS" gene complement(2114409..2115467) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /label="gmmB gene" promotor_-35 2114757..2114766 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2114777..2115567 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 2114777 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2114779..2114798 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2115508..2115527) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2115531) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2115539..2115546) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2115545..2115551 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 2115565..2115584 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 2115569..2115638 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 2115569 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="upshifts" promotor_-35 2115618..2115625 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2115640..2115732 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 2115640..2115659 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2115640 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="upshifts" CDS 2115733..2115981 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" /label="fer CDS" gene 2115733..2115981 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /label="fer gene" downshifts 2115965 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2116021..2116593) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" /label="fmnP CDS" gene complement(2116021..2116593) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /label="fmnP gene" downshifts complement(2116041) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2116585..2116892) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" /label="fswB RNA" gene complement(2116585..2116892) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /label="fswB gene" S_feature complement(2116594..2116698) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(2116891..2116910) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2116907) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2116924..2116930) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2117019..2117026 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2117037 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2117041..2117060 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2117090..2118667 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" /label="serA CDS" gene 2117090..2118667 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /label="serA gene" downshifts 2118649 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(2118710..2119477) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" /label="aroC CDS" gene complement(2118710..2119477) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /label="aroC gene" downshifts complement(2118725) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 2118979..2119591 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(2119504..2119523) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2119517) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2119538..2119541) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2119551 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS complement(2119589..2120695) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" /label="rsiX CDS" gene complement(2119589..2120695) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /label="rsiX gene" downshifts complement(2119606) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" /label="downshifts" CDS complement(2120631..2121215) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" /label="sigX CDS" gene complement(2120631..2121215) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /label="sigX gene" promotor_-35 2121009..2121014 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2121025 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2121029..2121033 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2121166..2121171 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2121183 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2121187..2121205 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2121223 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2121264..2121283) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2121268..2121375 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(2121272) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2121296..2121303) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2121331 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(2121360..2121418) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(2121391) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2121419..2123188) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" /label="resE CDS" gene complement(2121419..2123188) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /label="resE gene" downshifts complement(2121475) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2123185..2123907) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" /label="resD CDS" gene complement(2123185..2123907) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /label="resD gene" S_feature complement(2123908..2123987) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(2123988..2125163) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " /label="resC CDS" gene complement(2123988..2125163) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /label="resC gene" CDS complement(2125183..2126811) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" /label="resB CDS" gene complement(2125183..2126811) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /label="resB gene" CDS complement(2126808..2127347) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" /label="resA CDS" gene complement(2126808..2127347) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /label="resA gene" S_feature complement(2127348..2127441) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(2127442..2128176) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" /label="rluB CDS" gene complement(2127442..2128176) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /label="rluB gene" promotor_-10 complement(2128185..2128204) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2128208) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2128219..2128223) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2128268..2128804) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" /label="spmB CDS" gene complement(2128268..2128804) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /label="spmB gene" promotor_-10 complement(2128273..2128292) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2128277) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2128307..2128314) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2128809..2129399) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" /label="spmA CDS" gene complement(2128809..2129399) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /label="spmA gene" CDS complement(2129387..2130535) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" /label="dacB CDS" gene complement(2129387..2130535) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /label="dacB gene" promotor_-10 complement(2130557..2130575) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2130564) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2130590..2130595) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2130658..2131197) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" /label="ypuI CDS" gene complement(2130658..2131197) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /label="ypuI gene" downshifts complement(2130671) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2131206..2131223) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2131221) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2131238..2131243) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2131252..2131845) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" /label="spcB CDS" gene complement(2131252..2131845) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /label="spcB gene" CDS complement(2131835..2132590) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" /label="scpA CDS" gene complement(2131835..2132590) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /label="scpA gene" promotor_-35 2132434..2132443 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2132456..2132475 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2132465 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2132636..2132655) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2132651) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2132669..2132676) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2132816..2132823 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2132834..2132853 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2132839 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="upshifts" CDS 2132871..2133395 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" /label="ypuF CDS" gene 2132871..2133395 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /label="ypuF gene" CDS complement(2133409..2133783) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" /label="ypzK CDS" gene complement(2133409..2133783) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /label="ypzK gene" downshifts complement(2133425) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2133845..2133864) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2133857) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2133876..2133883) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2133896..2134360) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" /label="ribH CDS" gene complement(2133896..2134360) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /label="ribH gene" promotor_-35 2134231..2134235 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2134249..2134253 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2134252 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2134393..2135589) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" /label="ribBA CDS" gene complement(2134393..2135589) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /label="ribBA gene" CDS complement(2135604..2136251) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" /label="ribE CDS" gene complement(2135604..2136251) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /label="ribE gene" CDS complement(2136262..2137347) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" /label="ribD CDS" gene complement(2136262..2137347) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /label="ribD gene" S_feature complement(2137348..2137476) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(2137477..2137621) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" /label="fswA RNA" gene complement(2137477..2137621) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /label="fswA gene" promotor_-10 complement(2137638..2137657) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2137648) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2137672..2137679) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2137741..2138085) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" /label="ypuD CDS" gene complement(2137741..2138085) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /label="ypuD gene" downshifts complement(2137756) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2138117..2138135) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2138130) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2138144..2138149 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2138150..2138156) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2138164..2139086 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 2138164 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2138165..2138183 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2138171..2138186) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2138174) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2138176..2138242) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(2138199..2138208) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2138237..2138245) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2138242) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2138259..2138267) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2138320..2138874) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" /label="sipS CDS" gene complement(2138320..2138874) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /label="sipS gene" downshifts complement(2138330) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2138900..2138919) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2138918) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2138920..2139319) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(2138931..2138937) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2139141..2139377 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" /label="ypzC CDS" gene 2139141..2139377 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /label="ypzC gene" CDS complement(2139320..2139526) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" /label="ypzJ CDS" gene complement(2139320..2139526) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /label="ypzJ gene" misc_feature complement(2139559..2139578) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2139581) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="upshifts" CDS complement(2139635..2139889) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" /label="ypuC CDS" gene complement(2139635..2139889) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo /label="ypuC gene" promotor_-35 2139769..2139778 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2139780..2140169) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" /label="ypuC CDS" gene complement(2139780..2140169) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo /label="ypuC gene" S_feature 2139792..2140863 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 2139792..2139811 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2139792 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2140147..2140350) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" /label="ypuB CDS" gene complement(2140147..2140350) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /label="ypuB gene" CDS 2140759..2140875 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" /label="hypothetical protein CDS" gene 2140759..2140875 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo /label="gene" downshifts 2140826 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" /label="downshifts" promotor_-35 2140952..2140961 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2140974..2140993 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2140974 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="upshifts" CDS 2141016..2141228 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" /label="ypzD CDS" gene 2141016..2141228 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /label="ypzD gene" downshifts 2141222 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" downshifts complement(2141364) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2141364..2141795) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" /label="ppiB CDS" gene complement(2141364..2141795) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /label="ppiB gene" S_feature complement(2141796..2141882) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(2141865..2141884) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2141882) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2141898..2141903) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2141932..2141941 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2141951..2142048 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 2141951 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2141954..2141969 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2142049..2142921 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" /label="ypuA CDS" gene 2142049..2142921 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /label="ypuA gene" downshifts 2142828 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2142894 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2142951..2144270) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" /label="lysA CDS" gene complement(2142951..2144270) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /label="lysA gene" downshifts complement(2142971) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2144271..2144335) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(2144331..2144350) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2144335) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2144365..2144372) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2144376..2145857) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /translation="MPDHKEEKIRVYRNPAKNEEYFKNRVGMGTSYDVGVRKLTILDK EIQLYYLNGLCDTAYIIHLMRELVAINNRKEDPDELVDIVENRLLNAQVEKVKTLDET TDQVLSGLVAVIVEGAGFAFIIDVRSYPGRNPEEPDTEKVVRGARDGFVENIVVNTAL LRRRIRDERLRVKMTKVGERSKTDLSICYIEDIADPDLVEIVEKEIASIDVDGLTMAD KTVEEFIVNQSYNPFPLVRYTERPDVAANHVLEGHVIIIVDTSPSVIITPTTLFHHVQ HAEEYRQAPSVGTFLRWVRFFGILASTLFLPIWFLFVLQPDLLPDNMKFIGLNKDTHI PIILQIFLADLGIEFLRMAAIHTPTALSTAMGLIAAVLIGQIAIEVGLFSPEVILYVS LAAIGTFTTPSYELSLANKMSRLVLMILVALFHIKGLVIGFTVLIIAMASIKSLQTPY LWPLIPFNGKALWQVLVRTAKPGAKVRPSIVHPKNRLRQPTNS*" /label="spoVAF CDS" gene complement(2144376..2145857) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" /label="spoVAF gene" misc_feature complement(2145082..2145101) /Source="Nicolas_upshift_promotors" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2145086) /Source="Nicolas_upshifts" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2145808..2146419) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation germinant protein" /protein_id="YP_003097758.1" /db_xref="EnsemblGenomes-Gn:BSU23401" /db_xref="EnsemblGenomes-Tr:CAX52658" /db_xref="GOA:P40870" /db_xref="InterPro:IPR025914" /db_xref="UniProtKB/Swiss-Prot:P40870" /translation="MTTKRKVILVTDGDVYAAKTIEYAASKVGGRCISQSKGNPSTRS GAELVKLIASAPYDPVFVMFDDSGLQGEGPGEAALTYVATHPSIEVLGVIAVASKTHQ AEWTRVDVSIDRNGEITEYGVDKVGEREFDDHRMSGDTVYCLDKLDLPLIVGIGDIGK MGRKDDISKGSPITMKAVEFILERSGYHAGPQGRENSGLSESS*" /label="spoVAEA CDS" gene complement(2145808..2146419) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" /label="spoVAEA gene" CDS complement(2146427..2146777) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" /experiment="publication(s) with functional evidences, PMID:17573930, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17573930, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germinant protein" /protein_id="YP_003097759.1" /db_xref="EnsemblGenomes-Gn:BSU23402" /db_xref="EnsemblGenomes-Tr:CAX52659" /db_xref="GOA:C0H450" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014204" /db_xref="UniProtKB/Swiss-Prot:C0H450" /translation="MDYLLAFVCGGAICIVGQLLLDIFKLTPAHVMTSFVVIGAILDG FGIYDKFIEFAGGGATVPIVSFGHSLLHGAMHQAHIHGFIGIGMGIFELTSAGISAAI LFAFIVAVIFKPKG*" /label="spoVAEB CDS" gene complement(2146427..2146777) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" /label="spoVAEB gene" CDS complement(2146779..2147795) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 22328679, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 22328679, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AD (uptake of pyridine-2,6-dicarboxylic acid)" /protein_id="NP_390222.1" /db_xref="EnsemblGenomes-Gn:BSU23410" /db_xref="EnsemblGenomes-Tr:CAB14273" /db_xref="GOA:P40869" /db_xref="InterPro:IPR010894" /db_xref="InterPro:IPR016039" /db_xref="PDB:3LM6" /db_xref="SubtiList:BG10895" /db_xref="UniProtKB/Swiss-Prot:P40869" /translation="MKLTGKQTWVFEHPIFVNSAGTAAGPKEKDGPLGSLFDKTYDEM HCNQKSWEMAERQLMEDAVNVALQKNNLTKDDIDLLLAGDLLNQNVTANYVARHLKIP FLCMFGACSTSMETVAVASALVDGGFAKRALAATSSHNATAERQFRYPTEYGGQKPDT ATSTVTGSGAVVISQTPGDIQITSATVGKVSDLGITDPFDMGSAMAPAAADTIKQHFK DLNRTADDYDLILTGDLSGVGSPIVKDILKEDGYPVGTKHDDCGLLIYTPDQQVFAGG SGCACSAVVTYSHIFKQLREGKLNRVFVVATGALLSPTMIQQKETIPTIAHGVVFERA GGAS*" /label="spoVAD CDS" gene complement(2146779..2147795) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" /label="spoVAD gene" promotor_-35 2147275..2147282 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2147296..2147315 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2147318 /Source="Nicolas_upshifts" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2147808..2148260) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 24666282, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 24666282, 26604257, 27105070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="mechanosensitive channel; stage V sporulation protein AC" /protein_id="NP_390223.1" /db_xref="EnsemblGenomes-Gn:BSU23420" /db_xref="EnsemblGenomes-Tr:CAB14274" /db_xref="GOA:P40868" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014203" /db_xref="SubtiList:BG10894" /db_xref="UniProtKB/Swiss-Prot:P40868" /translation="MTNIKENYKSKVKTYQPKPPYVWNCVKAFLVGGLICAIGQGLQN FYIHFFDFNEKTAGNPTAATLILISALLTGFGIYDRIGQFAGAGSAVPVTGFANSMAS AALEYKSEGLVLGVATNMFKLAGNVIVFGVVAAYIVGMIRFAFEKLMS*" /label="spoVAC CDS" gene complement(2147808..2148260) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" /label="spoVAC gene" CDS complement(2148273..2148698) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AB" /protein_id="NP_390224.1" /db_xref="EnsemblGenomes-Gn:BSU23430" /db_xref="EnsemblGenomes-Tr:CAB14275" /db_xref="GOA:P40867" /db_xref="InterPro:IPR020144" /db_xref="SubtiList:BG10893" /db_xref="UniProtKB/Swiss-Prot:P40867" /translation="MIVSVLFIIFVGLGGGITVGAGFVAFLTVMGIIPRLMQLTKTMR FVQAYEAAVILGAVCGGWETLHMNHLYLTKWIAVPVGLLAGLFVGMLAAALTEVLNVL PILAKRIGLRSKIIILLMAIVIGKIAGSLFHWLYFIDHS*" /label="spoVAB CDS" gene complement(2148273..2148698) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" /label="spoVAB gene" CDS complement(2148688..2149308) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:3114420, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3114420, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AA" /protein_id="NP_390225.2" /db_xref="EnsemblGenomes-Gn:BSU23440" /db_xref="EnsemblGenomes-Tr:CAB14276" /db_xref="GOA:P40866" /db_xref="InterPro:IPR021997" /db_xref="SubtiList:BG10892" /db_xref="UniProtKB/Swiss-Prot:P40866" /translation="MERRIFIRLRHRVLAHPGDIITVGDAAQIEGQLQLKKKLSAMPL YQVSEKDKNIVILDIIQVLRAIHLQDPTIDVQTVGGAETIVEIQYRKRNLSTVLFIGV WLLLFIGSCLAIMNFHEDVSMRDVHIALYEIITGERNDYPYLLQIPYSIGLGLGMIVF FNHIFKKRLNEEPSPLEVEMFNYQLDLDQYVAMHENQETIKDLHDR*" /label="spoVAA CDS" gene complement(2148688..2149308) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" /label="spoVAA gene" promotor_-10 complement(2149339..2149350) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2149349) /Source="Nicolas_upshifts" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2149364..2149370) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2149433..2150200) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-F)" /protein_id="NP_390226.1" /db_xref="EnsemblGenomes-Gn:BSU23450" /db_xref="EnsemblGenomes-Tr:CAB14277" /db_xref="GOA:P07860" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014236" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10298" /db_xref="UniProtKB/Swiss-Prot:P07860" /translation="MDVEVKKNGKNAQLKDHEVKELIKQSQNGDQQARDLLIEKNMRL VWSVVQRFLNRGYEPDDLFQIGCIGLLKSVDKFDLTYDVRFSTYAVPMIIGEIQRFIR DDGTVKVSRSLKELGNKIRRAKDELSKTLGRVPTVQEIADHLEIEAEDVVLAQEAVRA PSSIHETVYENDGDPITLLDQIADNSEEKWFDKIALKEAISDLEEREKLIVYLRYYKD QTQSEVAERLGISQVQVSRLEKKILKQIKVQMDHTDG*" /label="sigF CDS" gene complement(2149433..2150200) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" /label="sigF gene" downshifts complement(2149463) /Source="Nicolas_upshifts" /id="D1225" /incds=0 /nref=89 /ntot=197 /MaxReadThrough="1.81932" /MaxDrop="7.16571" /score="21.6169221" /energy="-13.5" /TU="NA" /idTUdmin="U1834" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2150212..2150652) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" /EC_number="2.7.11.-" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15023063, 15187183, 15819616, 16166546, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023063, 15187183, 15819616, 16166546, 16824103, 22115775; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="anti-sigma factor (antagonist of sigma(F)) and serine kinase" /protein_id="NP_390227.1" /db_xref="EnsemblGenomes-Gn:BSU23460" /db_xref="EnsemblGenomes-Tr:CAB14278" /db_xref="GOA:P10728" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010194" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10297" /db_xref="UniProtKB/Swiss-Prot:P10728" /translation="MKNEMHLEFSALSQNESFARVTVASFIAQLDPTMDELTEIKTVV SEAVTNAIIHGYEENCEGKVYISVTLEDHVVYMTIRDEGLGITDLEEARQPLFTTKPE LERSGMGFTIMENFMDDVSIDSSPEMGTTIRLTKHLSKSKALCN*" /label="spoIIAB CDS" gene complement(2150212..2150652) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" /label="spoIIAB gene" CDS complement(2150649..2151002) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11173484, 15819616, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11173484, 15819616, 16824103, 22115775; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of SpoIIAB)" /protein_id="NP_390228.1" /db_xref="EnsemblGenomes-Gn:BSU23470" /db_xref="EnsemblGenomes-Tr:CAB14279" /db_xref="GOA:P10727" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR014237" /db_xref="InterPro:IPR036513" /db_xref="PDB:1AUZ" /db_xref="PDB:1BUZ" /db_xref="SubtiList:BG10296" /db_xref="UniProtKB/Swiss-Prot:P10727" /translation="MSLGIDMNVKESVLCIRLTGELDHHTAETLKQKVTQSLEKDDIR HIVLNLEDLSFMDSSGLGVILGRYKQIKQIGGEMVVCAISPAVKRLFDMSGLFKIIRF EQSEQQALLTLGVAS*" /label="spoIIAA CDS" gene complement(2150649..2151002) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" /label="spoIIAA gene" promotor_-10 complement(2151027..2151045) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2151038) /Source="Nicolas_upshifts" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2151040..2151097) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" promotor_-35 complement(2151057..2151065) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2151098..2152267) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" /label="dacF CDS" gene complement(2151098..2152267) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /label="dacF gene" promotor_-10 complement(2152296..2152307) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2152311) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2152321..2152327) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2152413) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2152422..2153237) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" /label="pupG CDS" gene complement(2152422..2153237) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /label="pupG gene" CDS complement(2153250..2154434) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" /label="deoB CDS" gene complement(2153250..2154434) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /label="deoB gene" promotor_-10 complement(2154483..2154502) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2154501) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2154503..2154594) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(2154518..2154525) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2154595..2155485) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" /label="ripX CDS" gene complement(2154595..2155485) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /label="ripX gene" CDS complement(2155493..2155720) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" /label="yqzK CDS" gene complement(2155493..2155720) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /label="yqzK gene" promotor_-10 complement(2155623..2155642) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2155634) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2155656..2155663) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2155713) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2155722..2155740) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2155750..2155768) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2155756..2155762) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2155763) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2155785..2155790) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2155845) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" /label="downshifts" CDS complement(2155845..2156294) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" /label="fur CDS" gene complement(2155845..2156294) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /label="fur gene" promotor_-10 complement(2156318..2156337) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(2156328) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="upshifts" S_feature complement(2156330..2156406) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(2156353..2156357) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(2156407..2157051) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" /label="spoIIM CDS" gene complement(2156407..2157051) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /label="spoIIM gene" promotor_-10 complement(2157082..2157100) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(2157099) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="upshifts" promotor_-35 complement(2157115..2157120) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(2157152..2157367) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" /label="yqkK CDS" gene complement(2157152..2157367) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /label="yqkK gene" downshifts complement(2157232) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2157467..2158786) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" /label="mleA CDS" gene complement(2157467..2158786) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /label="mleA gene" downshifts complement(2157474) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" CDS complement(2158804..2160210) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" /label="mleN CDS" gene complement(2158804..2160210) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /label="mleN gene" promotor_-10 complement(2160258..2160277) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2160267) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2160269..2160350) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(2160292..2160299) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2160351..2161778) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" /label="ansB CDS" gene complement(2160351..2161778) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /label="ansB gene" CDS complement(2161823..2162812) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" /label="ansA CDS" gene complement(2161823..2162812) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /label="ansA gene" S_feature complement(2162813..2162892) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(2162874..2162893) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2162892) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2162894..2163214) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(2162908..2162915) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2162933..2162940 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2162953..2162972 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2162955 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="upshifts" CDS 2162994..2163344 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" /label="ansR CDS" gene 2162994..2163344 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /label="ansR gene" S_feature complement(2163216..2163352) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(2163259) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" /label="downshifts" CDS complement(2163353..2164516) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" /label="yqxK CDS" gene complement(2163353..2164516) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /label="yqxK gene" CDS complement(2164513..2165070) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" /label="nudF CDS" gene complement(2164513..2165070) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /label="nudF gene" promotor_no_box complement(2165000..2165100) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2165040) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2165084..2165089 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2165105..2165123 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2165107..2165121) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 2165111 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="upshifts" S_feature 2165118..2165292 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(2165123..2165126) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(2165126) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="upshifts" CDS 2165145..2165267 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" /label="mciZ CDS" gene 2165145..2165267 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /label="mciZ gene" promotor_-35 2165268..2165275 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2165289..2165308 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2165294 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="upshifts" CDS 2165330..2166250 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" /label="yqkF CDS" gene 2165330..2166250 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /label="yqkF gene" downshifts 2166239 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2166282..2166506) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" /label="yqkE CDS" gene complement(2166282..2166506) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /label="yqkE gene" downshifts complement(2166339) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2166529..2166548) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2166536) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2166563..2166570) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2166585..2166592 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2166607..2166626 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2166614 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="upshifts" CDS 2166668..2167585 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" /label="yqkD CDS" gene 2166668..2167585 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /label="yqkD gene" downshifts 2167560 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" /label="downshifts" CDS complement(2167625..2167864) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" /label="yqkC CDS" gene complement(2167625..2167864) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /label="yqkC gene" downshifts complement(2167636) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2167877..2168200) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" /label="yqkB CDS" gene complement(2167877..2168200) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /label="yqkB gene" promotor_-10 complement(2167943..2167962) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2167944) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2167976..2167983) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2168197..2169228) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" /label="yqkA CDS" gene complement(2168197..2169228) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /label="yqkA gene" promotor_-10 complement(2168224..2168243) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2168231) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2168254..2168261) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2169221..2169565) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" /label="yqjZ CDS" gene complement(2169221..2169565) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /label="yqjZ gene" CDS complement(2169575..2170045) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" /label="yqjY CDS" gene complement(2169575..2170045) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /label="yqjY gene" S_feature complement(2170046..2170122) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 2170046 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2170097..2170116) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2170122) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2170124..2170230) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(2170131..2170138) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2170231..2170569) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" /label="yqjX CDS" gene complement(2170231..2170569) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /label="yqjX gene" CDS complement(2170566..2171804) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" /label="polYB CDS" gene complement(2170566..2171804) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /label="polYB gene" misc_feature 2170728..2170729 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2170739 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2170794 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2171829..2171847) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(2171838) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="upshifts" promotor_-35 complement(2171864..2171869) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 2171909..2171912 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2171927..2171946 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2171936 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="upshifts" CDS 2171970..2172176 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" /label="yqzH CDS" gene 2171970..2172176 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /label="yqzH gene" promotor_-35 2172659..2172662 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2172677..2172696 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2172693 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="upshifts" CDS 2172725..2173957 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" /label="yqjV CDS" gene 2172725..2173957 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /label="yqjV gene" CDS 2173804..2174166 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" /label="yqjU CDS" gene 2173804..2174166 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /label="yqjU gene" S_feature complement(2173983..2174162) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(2174016) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2174163..2174549) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" /label="yqjT CDS" gene complement(2174163..2174549) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /label="yqjT gene" CDS complement(2174553..2175512) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" /label="coaA CDS" gene complement(2174553..2175512) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /label="coaA gene" S_feature complement(2175513..2175583) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(2175584..2176930) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" /label="dsdA CDS" gene complement(2175584..2176930) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /label="dsdA gene" S_feature complement(2176931..2177005) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(2177006..2177785) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" /label="yqjQ CDS" gene complement(2177006..2177785) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /label="yqjQ gene" CDS complement(2177791..2178750) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" /label="yqjP CDS" gene complement(2177791..2178750) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /label="yqjP gene" promotor_-10 complement(2178772..2178791) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2178791) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2178806..2178813) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2178847..2178854 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2178868..2179154 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 2178868 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2178870..2178889 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2178884..2179129 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" /label="pswI RNA" gene 2178884..2179129 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /label="pswI gene" CDS 2179155..2179991 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" /label="proI CDS" gene 2179155..2179991 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /label="proI gene" downshifts 2179989 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2180032..2181675) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" /label="yqjN CDS" gene complement(2180032..2181675) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /label="yqjN gene" downshifts complement(2180044) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2181693..2181699 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2181706 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2181713..2181724 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2181731..2181750) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2181736) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2181782..2181789 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2181803..2181822 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2181805 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2181847..2182863 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" /label="yqjM CDS" gene 2181847..2182863 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /label="yqjM gene" downshifts 2182850 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 2182912..2182921 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2182934..2182949 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2182938 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2182973..2183734 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" /label="yqjL CDS" gene 2182973..2183734 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /label="yqjL gene" downshifts 2183642 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2183730 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2183762..2183962) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(2183778..2183903) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" /label="rpmGCc CDS" gene complement(2183778..2183903) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo /label="rpmGCc gene" downshifts complement(2183805) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2183896..2183928) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" /label="rpmGCn CDS" gene complement(2183896..2183928) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo /label="rpmGCn gene" promotor_-10 complement(2183956..2183975) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2183962) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2183988..2183995) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2184010..2184933) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" /label="rnz CDS" gene complement(2184010..2184933) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /label="rnz gene" promotor_-10 complement(2184959..2184978) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2184972) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2184992..2184997) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2185071..2185078 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2185092..2185111 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2185094..2185159 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 2185094 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="upshifts" CDS 2185160..2186629 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" /label="zwf CDS" gene 2185160..2186629 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /label="zwf gene" downshifts 2186612 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" terminator 2186637..2186676 /created_by="User" /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" /label="Delta6_zwf-T-gndA_Terminator" Polymorphism join(2186649,2186652) /Source="geneious" /ID="SNP_BsDelta6_2480646_2480647" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="TA -> AT" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TA" /Variant_Nucleotides="AT" /Variant_P_Value=0 /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2186657,2186658) /Source="geneious" /ID="SNP_BsDelta6_2480654_2480654" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.1e-279" /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2186669,2186670) /Source="geneious" /ID="SNP_BsDelta6_2480667_2480667" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=116 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.9e-244" /Variant_Raw_Frequency=110 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2186678 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2186752..2188161) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" /label="gndA CDS" gene complement(2186752..2188161) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /label="gndA gene" downshifts complement(2186769) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" downshifts complement(2186842) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" misc_feature complement(2188225..2188243) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2188227) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2188271..2189515) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" /label="polYA CDS" gene complement(2188271..2189515) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /label="polYA gene" S_feature complement(2189516..2189790) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 2189536..2189543 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2189557..2189576 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2189557 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="upshifts" CDS 2189588..2189875 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" /label="mifM CDS" gene 2189588..2189875 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /label="mifM gene" promotor_-10 complement(2189772..2189791) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(2189792) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="upshifts" promotor_-35 complement(2189807..2189810) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 2189906..2190733 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " /label="oxaAB CDS" gene 2189906..2190733 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /label="oxaAB gene" downshifts 2190550 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2190726 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2190738..2191658) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(2190781) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2190851..2190857 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2190871..2190889 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2190880 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="upshifts" CDS 2190913..2191641 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" /label="yqjF CDS" gene 2190913..2191641 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /label="yqjF gene" CDS complement(2191682..2192797) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" /label="yqjE CDS" gene complement(2191682..2192797) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /label="yqjE gene" downshifts complement(2191703) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" CDS complement(2192815..2194338) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " /label="yqjD CDS" gene complement(2192815..2194338) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /label="yqjD gene" promotor_-10 complement(2193921..2193940) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2193943) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2193955..2193959) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2194331..2194753) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" /label="yqjC CDS" gene complement(2194331..2194753) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /label="yqjC gene" promotor_-35 2194782..2194789 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2194803..2194822 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2194817..2194970 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 2194817 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="upshifts" downshifts 2194927 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" CDS complement(2194955..2195485) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" /label="yqjB CDS" gene complement(2194955..2195485) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /label="yqjB gene" S_feature 2194972..2195607 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(2195502..2195513) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2195509) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2195528..2195534) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2195537..2196505) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" /label="yqjA CDS" gene complement(2195537..2196505) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /label="yqjA gene" downshifts complement(2195553) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2196576..2197298) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" /label="artR CDS" gene complement(2196576..2197298) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /label="artR gene" downshifts complement(2196587) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS complement(2197291..2197950) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" /label="artQ CDS" gene complement(2197291..2197950) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /label="artQ gene" S_feature complement(2197951..2198030) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(2198031..2198798) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" /label="artP CDS" gene complement(2198031..2198798) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /label="artP gene" promotor_-10 complement(2198848..2198867) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2198863) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2198882..2198889) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2199066..2199503) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" /label="brxB CDS" gene complement(2199066..2199503) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /label="brxB gene" downshifts complement(2199075) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2199527..2199546) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(2199548) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="upshifts" promotor_-35 complement(2199561..2199568) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 2199601..2199607 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2199620 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2199622..2199640 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2199664..2200557 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" /label="bmrU CDS" gene 2199664..2200557 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /label="bmrU gene" promotor_-35 2200590..2200597 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2200613..2200632 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2200621 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" CDS 2200658..2201827 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" /label="bmr CDS" gene 2200658..2201827 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /label="bmr gene" downshifts 2201810 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" CDS 2201900..2202736 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" /label="bmrR CDS" gene 2201900..2202736 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /label="bmrR gene" downshifts 2202734 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2202798) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2202798..2204072) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" /label="bkdB CDS" gene complement(2202798..2204072) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /label="bkdB gene" CDS complement(2204095..2205078) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" /label="bkdAB CDS" gene complement(2204095..2205078) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /label="bkdAB gene" CDS complement(2205092..2206084) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" /label="bkdAA CDS" gene complement(2205092..2206084) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /label="bkdAA gene" CDS complement(2206106..2207530) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" /label="lpdV CDS" gene complement(2206106..2207530) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /label="lpdV gene" CDS complement(2207551..2208642) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" /label="buk CDS" gene complement(2207551..2208642) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /label="buk gene" CDS complement(2208661..2209755) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" /label="bcd CDS" gene complement(2208661..2209755) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /label="bcd gene" CDS complement(2209767..2210666) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" /label="ptb CDS" gene complement(2209767..2210666) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /label="ptb gene" misc_feature complement(2210702..2210721) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2210707) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2210709..2210790) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2210791..2212869) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" /label="bkdR CDS" gene complement(2210791..2212869) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /label="bkdR gene" promotor_-10 complement(2212929..2212948) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2212946) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2212956..2212963 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2212965..2212968) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2212977..2212996 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2212984 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="upshifts" CDS 2213022..2213258 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" /label="yqzF CDS" gene 2213022..2213258 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /label="yqzF gene" downshifts 2213249 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2213300..2214205) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" /label="mmgF CDS" gene complement(2213300..2214205) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /label="mmgF gene" downshifts complement(2213303) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2214223..2215641) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" /label="mmgE CDS" gene complement(2214223..2215641) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /label="mmgE gene" misc_feature complement(2214518..2214537) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2214535) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2215656..2216774) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" /label="mmgD CDS" gene complement(2215656..2216774) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /label="mmgD gene" CDS complement(2216808..2217947) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" /label="mmgC CDS" gene complement(2216808..2217947) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /label="mmgC gene" CDS complement(2217975..2218838) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" /label="mmgB CDS" gene complement(2217975..2218838) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /label="mmgB gene" CDS complement(2218863..2220044) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" /label="mmgA CDS" gene complement(2218863..2220044) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /label="mmgA gene" downshifts complement(2219624) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" /label="downshifts" misc_feature complement(2219731..2219737) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2219734) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2219958..2220058) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2219998) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2220091..2220109) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2220109) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2220125..2220130) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2220171..2220902) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" /label="glpQ CDS" gene complement(2220171..2220902) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /label="glpQ gene" downshifts complement(2220178) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2220925..2220944) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2220936) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2220959..2220962) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2220981..2221601) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" /label="yqiI CDS" gene complement(2220981..2221601) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /label="yqiI gene" CDS complement(2221616..2221909) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" /label="yqiH CDS" gene complement(2221616..2221909) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /label="yqiH gene" promotor_-10 complement(2221929..2221948) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2221935) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2221963..2221970) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2222165..2222172 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2222186..2222205 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2222203..2222408 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2222203 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2222217..2222369 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" /label="hypothetical protein CDS" gene 2222217..2222369 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /label="gene" promotor_-35 2222377..2222384 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2222399..2222418 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2222410 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2222442..2223560 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" /label="yqiG CDS" gene 2222442..2223560 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /label="yqiG gene" downshifts 2223545 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2223587..2223757) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2223630) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2223741..2223756) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2223757) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2223759..2223887) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2223768..2223777) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2223886..2223905) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2223909) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2223919..2223927) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2224019) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2224025..2224828) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" /label="spo0A CDS" gene complement(2224025..2224828) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /label="spo0A gene" promotor_-10 complement(2224871..2224889) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2224877) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2224879..2225031) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2224900..2224908) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2225027..2225046) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2225039) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2225058..2225065) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2225104..2226384) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="regulatory membrane-associated serine protease" /protein_id="NP_390303.2" /db_xref="EnsemblGenomes-Gn:BSU24230" /db_xref="EnsemblGenomes-Tr:CAB14354" /db_xref="GOA:P17896" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008763" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR014219" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG10311" /db_xref="UniProtKB/Swiss-Prot:P17896" /translation="MPDNIRKAVGLILLVSLLSVGLCKPLKEYLLIPTQMRVFETQTQ AIETSLSVNAQTSESSEAFTVKKDPHEIKVTGKKSGESELVYDLAGFPIKKTKVHVLP DLKVIPGGQSIGVKLHSVGVLVVGFHQINTSEGKKSPGETAGIEAGDIIIEMNGQKIE KMNDVAPFIQKAGKTGESLDLLIKRDKQKIKTKLIPEKDEGEGKYRIGLYIRDSAAGI GTMTFYEPKTKKYGALGHVISDMDTKKPIVVENGEIVKSTVTSIEKGTGGNPGEKLAR FSSERKTIGDINRNSPFGIFGTLHQPIQNNISDQALPVAFSTEVKKGPAEILTVIDDD KVEKFDIEIVSTTPQKFPATKGMVLKITDPRLLKETGGIVQGMSGSPIIQNGKVIGAV THVFVNDPTSGYGVHIEWMLSEAGIDIYGKEKAS*" /label="spoIVB CDS" gene complement(2225104..2226384) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /label="spoIVB gene" downshifts complement(2225119) /Source="Nicolas_upshifts" /id="D1266" /incds=0 /nref=34 /ntot=51 /MaxReadThrough="1.04939" /MaxDrop="7.80695" /score="49.1812184" /energy="-12.5" /TU="NA" /idTUdmin="U1893" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2226445..2226456) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2226459) /Source="Nicolas_upshifts" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2226471..2226477) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2226559..2228289) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" /label="recN CDS" gene complement(2226559..2228289) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /label="recN gene" downshifts complement(2226574) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2228326..2228775) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" /label="argR CDS" gene complement(2228326..2228775) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /label="argR gene" S_feature complement(2228776..2228861) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2228873..2229718) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" /label="yqxC CDS" gene complement(2228873..2229718) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /label="yqxC gene" downshifts complement(2228906) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" /label="downshifts" CDS complement(2229715..2231616) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" /label="dxs CDS" gene complement(2229715..2231616) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /label="dxs gene" promotor_-35 2230824..2230830 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2230845..2230856 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2230853 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2231617..2231745) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2231740..2231759) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2231745) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2231774..2231780) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2231791..2232681) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" /label="ispA CDS" gene complement(2231791..2232681) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /label="ispA gene" CDS complement(2232671..2232925) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" /label="xseB CDS" gene complement(2232671..2232925) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /label="xseB gene" CDS complement(2232922..2234268) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" /label="xseA CDS" gene complement(2232922..2234268) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /label="xseA gene" S_feature complement(2234269..2234405) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2234406..2235257) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" /label="folD CDS" gene complement(2234406..2235257) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /label="folD gene" CDS complement(2235269..2235664) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" /label="nusB CDS" gene complement(2235269..2235664) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /label="nusB gene" misc_feature complement(2235707..2235726) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2235726) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2235728..2235890) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2235928..2236335) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" /label="yqhY CDS" gene complement(2235928..2236335) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /label="yqhY gene" downshifts complement(2235935) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" /label="downshifts" CDS complement(2236356..2237708) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" /label="accC CDS" gene complement(2236356..2237708) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /label="accC gene" promotor_-10 complement(2237237..2237256) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2237244) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="upshifts" promotor_-35 complement(2237271..2237277) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2237720..2238199) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " /label="accB CDS" gene complement(2237720..2238199) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /label="accB gene" promotor_-10 complement(2238258..2238277) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2238269) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2238291..2238298) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2238355..2239011) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" /label="spoIIIAH CDS" gene complement(2238355..2239011) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /label="spoIIIAH gene" downshifts complement(2238362) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" CDS complement(2239012..2239701) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" /label="spoIIIAG CDS" gene complement(2239012..2239701) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /label="spoIIIAG gene" CDS complement(2239694..2240314) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" /label="spoIIIAF CDS" gene complement(2239694..2240314) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /label="spoIIIAF gene" promotor_-10 complement(2240020..2240038) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2240038) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2240054..2240059) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2240328..2241527) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" /label="spoIIIAE CDS" gene complement(2240328..2241527) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /label="spoIIIAE gene" CDS complement(2241546..2241947) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" /label="spoIIIAD CDS" gene complement(2241546..2241947) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /label="spoIIIAD gene" CDS complement(2241954..2242160) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" /label="spoIIIAC CDS" gene complement(2241954..2242160) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /label="spoIIIAC gene" CDS complement(2242183..2242698) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" /label="spoIIIAB CDS" gene complement(2242183..2242698) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /label="spoIIIAB gene" CDS complement(2242692..2243615) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" /label="spoIIIAA CDS" gene complement(2242692..2243615) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /label="spoIIIAA gene" S_feature complement(2243616..2243690) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2243691..2243972) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" /label="yqhV CDS" gene complement(2243691..2243972) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /label="yqhV gene" promotor_-10 complement(2243992..2244010) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2244015) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="upshifts" promotor_-35 complement(2244026..2244031) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2244117..2244674) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" /label="efp CDS" gene complement(2244117..2244674) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /label="efp gene" downshifts complement(2244129) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2244699..2245760) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" /label="papA CDS" gene complement(2244699..2245760) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /label="papA gene" CDS complement(2245757..2246203) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" /label="yqhS CDS" gene complement(2245757..2246203) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /label="yqhS gene" promotor_-10 complement(2246252..2246271) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2246268) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2246284..2246291) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2246290..2246826) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" /label="yqhR CDS" gene complement(2246290..2246826) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /label="yqhR gene" promotor_-10 complement(2246839..2246850) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2246848) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="upshifts" promotor_-35 complement(2246864..2246870) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2246896..2246902 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2246915 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2246917..2246935 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2246972..2246975 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2246990..2247009 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2247001 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" CDS 2247053..2248009 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" /label="yqhQ CDS" gene 2247053..2248009 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /label="yqhQ gene" CDS 2248049..2248444 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" /label="yqhP CDS" gene 2248049..2248444 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /label="yqhP gene" promotor_no_box 2248327..2248427 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2248387 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2248430 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2248441..2249316) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" /label="yqhO CDS" gene complement(2248441..2249316) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /label="yqhO gene" promotor_-10 complement(2249343..2249361) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2249360) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2249377..2249382) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2249442..2249870) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" /label="mntR CDS" gene complement(2249442..2249870) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /label="mntR gene" downshifts complement(2249469) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2249905..2249924) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2249913) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2249940..2249944) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2249970..2250806) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" /label="lipM CDS" gene complement(2249970..2250806) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /label="lipM gene" promotor_-10 complement(2250830..2250849) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2250841) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2250843..2251387) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2250863..2250870) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2250887..2250892 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2250906..2250925 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2250906 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="upshifts" S_feature 2250917..2250996 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2250997..2251377 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" /label="yqhL CDS" gene 2250997..2251377 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /label="yqhL gene" downshifts 2251313 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2251357 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2251412..2252878) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" /label="gcvPB CDS" gene complement(2251412..2252878) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /label="gcvPB gene" downshifts complement(2251432) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" /label="downshifts" CDS complement(2252871..2254217) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" /label="gcvPA CDS" gene complement(2252871..2254217) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /label="gcvPA gene" CDS complement(2254247..2255335) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" /label="gcvT CDS" gene complement(2254247..2255335) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /label="gcvT gene" misc_RNA complement(2255409..2255608) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" /label="swgA RNA" gene complement(2255409..2255608) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /label="swgA gene" downshifts complement(2255459) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" /label="downshifts" S_feature complement(2255609..2255679) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2255612..2255617 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2255633..2255651 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2255637 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2255647..2255776 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2255665..2255684) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2255679) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="upshifts" promotor_-35 complement(2255698..2255705) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2255777..2257450 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" /label="yqhH CDS" gene 2255777..2257450 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /label="yqhH gene" CDS 2257471..2258265 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" /label="yqhG CDS" gene 2257471..2258265 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /label="yqhG gene" misc_feature 2257801..2257802 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2257807 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="upshifts" promotor_-35 2258289..2258292 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2258308..2258327 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2258309..2258447 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2258309 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2258448..2258621 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" /label="sinI CDS" gene 2258448..2258621 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /label="sinI gene" promotor_-35 2258606..2258610 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2258623..2258642 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2258623 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2258655..2258990 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" /label="sinR CDS" gene 2258655..2258990 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /label="sinR gene" downshifts 2258967 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts 2259057 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2259083..2259868) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="major biofilm matrix component" /protein_id="NP_390342.1" /db_xref="EnsemblGenomes-Gn:BSU24620" /db_xref="EnsemblGenomes-Tr:CAB14393" /db_xref="GOA:P54507" /db_xref="InterPro:IPR022121" /db_xref="InterPro:IPR023833" /db_xref="SubtiList:BG11697" /db_xref="UniProtKB/Swiss-Prot:P54507" /translation="MGMKKKLSLGVASAALGLALVGGGTWAAFNDIKSKDATFASGTL DLSAKENSASVNLSNLKPGDKLTKDFQFENNGSLAIKEVLMALNYGDFKANGGSNTSP EDFLSQFEVTLLTVGKEGGNGYPKNIILDDANLKDLYLMSAKNDAAAAEKIKKQIDPK FLNASGKVNVATIDGKTAPEYDGVPKTPTDFDQVQMEIQFKDDKTKDEKGLMVQNKYQ GNSIKLQFSFEATQWNGLTIKKDHTDKDGYVKENEKAHSEDKN*" /label="tasA CDS" gene complement(2259083..2259868) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" /label="tasA gene" downshifts complement(2259089) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2259921..2259938) /Source="Nicolas_upshift_promotors" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2259925) /Source="Nicolas_upshifts" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2259932..2260504) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390343.1" /db_xref="EnsemblGenomes-Gn:BSU24630" /db_xref="EnsemblGenomes-Tr:CAB14394" /db_xref="GOA:P54506" /db_xref="InterPro:IPR001733" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11696" /db_xref="UniProtKB/Swiss-Prot:P54506" /translation="MKLISNILYVIIFTLIIVLTLVVISTRSSGGEPAVFGYTLKSVL SGSMEPEFNTGSLILVKEITDVKELQKGDVITFMQDANTAVTHRIVDITKQGDHLLFK TKGDNNAAADSAPVSDENVRAQYTGFQLPYAGYMLHFASQPIGTAVLLIVPGVMLLVY AFVTISSAIREIERKTKALETDTKDSTMST*" /label="sipW CDS" gene complement(2259932..2260504) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" /label="sipW gene" CDS complement(2260488..2261249) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein for biofilm formation" /protein_id="NP_390344.1" /db_xref="EnsemblGenomes-Gn:BSU24640" /db_xref="EnsemblGenomes-Tr:CAB14395" /db_xref="GOA:P40949" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023833" /db_xref="InterPro:IPR023848" /db_xref="SubtiList:BG11076" /db_xref="UniProtKB/Swiss-Prot:P40949" /translation="MFRLFHNQQKAKTKLKVLLIFQLSVIFSLTAAICLQFSDDTSAA FHDIETFDVSLQTCKDFQHTDKNCHYDKRWDQSDLHISDQTDTKGTVCSPFALFAVLE NTGEKLKKSKWKWELHKLENARKPLKDGNVIEKGFVSNQIGDSLYKIETKKKMKPGIY AFKVYKPAGYPANGSTFEWSEPMRLAKCDEKPTVPKKETKSDVKKENETTQKDIPEKT MKEETSQEAVTKEKETQSDQKESGEEDEKSNEADQ*" /label="tapA CDS" gene complement(2260488..2261249) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" /label="tapA gene" promotor_-10 complement(2261309..2261328) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-10" upshifts complement(2261327) /Source="Nicolas_upshifts" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="upshifts" promotor_-35 complement(2261342..2261349) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-35" promotor_-35 2261471..2261477 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2261478 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2261491..2261502 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2261521..2261847 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" /label="yqzG CDS" gene 2261521..2261847 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /label="yqzG gene" S_feature complement(2261664..2261888) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2261707) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2261829 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2261889..2262068) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" /label="spoIIT CDS" gene complement(2261889..2262068) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /label="spoIIT gene" promotor_-10 complement(2262087..2262105) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2262102) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2262120..2262126) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2262139..2262513) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" /label="comGG CDS" gene complement(2262139..2262513) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /label="comGG gene" CDS complement(2262514..2262897) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" /label="comGF CDS" gene complement(2262514..2262897) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /label="comGF gene" CDS complement(2262923..2263270) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" /label="comGE CDS" gene complement(2262923..2263270) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /label="comGE gene" CDS complement(2263254..2263685) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" /label="comGD CDS" gene complement(2263254..2263685) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /label="comGD gene" CDS complement(2263675..2263971) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" /label="comGC CDS" gene complement(2263675..2263971) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /label="comGC gene" CDS complement(2263985..2264956) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" /label="comGB CDS" gene complement(2263985..2264956) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /label="comGB gene" CDS complement(2265009..2266079) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" /label="comGA CDS" gene complement(2265009..2266079) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /label="comGA gene" promotor_-10 complement(2266097..2266116) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2266113) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2266130..2266137) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2266262..2266490) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2266303) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2266491..2267444) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" /label="yqxL CDS" gene complement(2266491..2267444) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /label="yqxL gene" promotor_-10 complement(2267468..2267487) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2267489) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2267501..2267507) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2267527..2267533 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2267548..2267566 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2267566 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="upshifts" CDS 2267587..2268915 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" /label="yqhB CDS" gene 2267587..2268915 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /label="yqhB gene" S_feature 2268916..2269890 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2268968..2269804) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" /label="rsbRD CDS" gene complement(2268968..2269804) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /label="rsbRD gene" S_feature complement(2269805..2269989) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2269891..2269961 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Gln1 tRNA" gene 2269891..2269961 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /label="trnSL-Gln1 gene" CDS complement(2270028..2270408) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" /label="mgsR CDS" gene complement(2270028..2270408) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /label="mgsR gene" downshifts complement(2270034) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2270437..2270455) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2270456) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2270470..2270476) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2270495..2270500 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2270516..2270534 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2270525 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="upshifts" promotor_-35 2270575..2270582 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2270597 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="upshifts" promotor_-10 2270598..2270617 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2270640..2270885 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" /label="yqgY CDS" gene 2270640..2270885 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /label="yqgY gene" downshifts 2270782 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" /label="downshifts" downshifts 2270871 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" /label="downshifts" S_feature 2270916..2271671 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2270925..2271560) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" /label="yqgX CDS" gene complement(2270925..2271560) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /label="yqgX gene" downshifts complement(2270950) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2271582..2271601) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2271599) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2271615..2271622) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2271639..2271646 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2271661..2271680 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2271673 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2271693) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2271695..2271709) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2271717..2271721) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2271717..2271890 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" /label="yqgW CDS" gene 2271717..2271890 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /label="yqgW gene" downshifts 2271878 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" /label="downshifts" CDS complement(2271922..2272236) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" /label="yqgV CDS" gene complement(2271922..2272236) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /label="yqgV gene" S_feature 2271923..2272990 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2271936) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2272239..2273300) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" /label="yqgU CDS" gene complement(2272239..2273300) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /label="yqgU gene" CDS complement(2273362..2274492) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" /label="yqgT CDS" gene complement(2273362..2274492) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /label="yqgT gene" promotor_-10 complement(2274500..2274518) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2274532) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2274534..2274539) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2274575..2276491) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" /label="ltaSC CDS" gene complement(2274575..2276491) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /label="ltaSC gene" downshifts complement(2274602) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" /label="downshifts" promotor_-35 2275607..2275613 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2275626..2276655 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2275626 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2275629..2275647 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2276492..2276558) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2276552..2276571) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2276558) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2276586..2276593) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2276608..2277573) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" /label="glcK CDS" gene complement(2276608..2277573) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /label="glcK gene" CDS complement(2277584..2277799) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" /label="yqgQ CDS" gene complement(2277584..2277799) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /label="yqgQ gene" S_feature complement(2277800..2277908) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2277909..2279432) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " /label="glpG CDS" gene complement(2277909..2279432) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /label="glpG gene" promotor_-10 complement(2279450..2279469) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2279463) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2279484..2279491) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2279522..2279695) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" /label="yqgO CDS" gene complement(2279522..2279695) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /label="yqgO gene" downshifts complement(2279549) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2279711..2279722) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2279723) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2279736..2279742) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2279762..2280325) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" /label="folN CDS" gene complement(2279762..2280325) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /label="folN gene" S_feature complement(2280326..2280409) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2280410..2280559) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" /label="rpmGA CDS" gene complement(2280410..2280559) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /label="rpmGA gene" downshifts complement(2280456) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2280596..2280615) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2280606) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2280631..2280634) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2280643..2281722) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" /label="yqgM CDS" gene complement(2280643..2281722) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /label="yqgM gene" CDS complement(2281719..2282189) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" /label="yqgL CDS" gene complement(2281719..2282189) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /label="yqgL gene" promotor_-35 2282134..2282142 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2282156..2282164 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2282157..2282330 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2282158 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2282225..2282244) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2282237) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2282256..2282263) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2282302..2282306 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2282322..2282341 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2282332 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" CDS 2282369..2282722 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" /label="yqzD CDS" gene 2282369..2282722 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /label="yqzD gene" CDS 2282719..2283183 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" /label="yqzC CDS" gene 2282719..2283183 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /label="yqzC gene" downshifts 2283169 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2283212..2283994) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" /label="pstBB CDS" gene complement(2283212..2283994) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /label="pstBB gene" downshifts complement(2283223) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2284005..2284814) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" /label="pstBA CDS" gene complement(2284005..2284814) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /label="pstBA gene" CDS complement(2284835..2285719) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" /label="pstA CDS" gene complement(2284835..2285719) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /label="pstA gene" CDS complement(2285719..2286648) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" /label="pstC CDS" gene complement(2285719..2286648) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /label="pstC gene" CDS complement(2286717..2287619) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" /label="pstS CDS" gene complement(2286717..2287619) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /label="pstS gene" upshifts complement(2287674) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2287682..2287698) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2287709..2287711) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" Polymorphism join(2287728,2287730) /Source="geneious" /ID="SNP_BsDelta6_2581727_2581726" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)6 -> (T)7" /Codon_Change /Coverage=117 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=114 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2287774..2289924) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" /label="pbpA CDS" gene complement(2287774..2289924) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /label="pbpA gene" downshifts complement(2287784) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2288518..2288536) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2288526) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2288552..2288558) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2289213..2289232) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2289230) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2289246..2289255) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2289974..2289993) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2289979) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2290009..2290013) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2290038..2291330) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" /label="yqgE CDS" gene complement(2290038..2291330) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /label="yqgE gene" promotor_-10 complement(2291353..2291364) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2291364) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2291378..2291384) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2291437..2292045) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" /label="sodA CDS" gene complement(2291437..2292045) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /label="sodA gene" downshifts complement(2291452) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2292097..2292116) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2292108) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2292110..2292178) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2292131..2292138) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2292169..2292187) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2292178) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2292202..2292208) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2292224..2292706) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" /label="yqgC CDS" gene complement(2292224..2292706) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /label="yqgC gene" S_feature complement(2292707..2292999) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2292749..2292755 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2292770..2292789 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2292783 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="upshifts" CDS 2292816..2293583 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" /label="yqgB CDS" gene 2292816..2293583 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /label="yqgB gene" promotor_-10 complement(2292997..2293015) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2292999) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="upshifts" S_feature complement(2293001..2293937) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2293029..2293035) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2293584..2294014 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2293971 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(2293982) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" CDS complement(2293999..2294427) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" /label="yqgA CDS" gene complement(2293999..2294427) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /label="yqgA gene" promotor_-35 2294423..2294427 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2294437..2294451 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2294446 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="upshifts" promotor_-10 complement(2294450..2294469) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2294473) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="upshifts" promotor_-35 complement(2294484..2294491) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2294642..2294647 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2294663..2294681 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2294675 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2294704..2295003 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" /label="yqfZ CDS" gene 2294704..2295003 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /label="yqfZ gene" promotor_-35 2295016..2295023 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2295038..2295057 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2295049..2295125 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2295049 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2295126..2296259 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" /label="ispG CDS" gene 2295126..2296259 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /label="ispG gene" downshifts 2296240 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(2296285..2296674) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" /label="yqfX CDS" gene complement(2296285..2296674) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /label="yqfX gene" downshifts complement(2296311) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2296705..2296716) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2296709) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2296730..2296736) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2296749..2296756 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2296767..2296786 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2296768 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="upshifts" CDS 2296807..2297388 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" /label="yqfW CDS" gene 2296807..2297388 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /label="yqfW gene" downshifts 2297386 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" /label="downshifts" S_feature 2297431..2298039 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2297431..2297868) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" /label="zur CDS" gene complement(2297431..2297868) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /label="zur gene" downshifts complement(2297435) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2297869..2297963) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2297959..2297978) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2297963) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2297993..2298000) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2298006..2298887) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" /label="yqfU CDS" gene complement(2298006..2298887) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /label="yqfU gene" promotor_-35 2298883..2298888 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2298904..2298922 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2298920 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2298925..2298944) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2298931) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2298933..2299260) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2298949..2298958 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2298965 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2298971..2298990 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2299003..2299257 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" /label="yqfT CDS" gene 2299003..2299257 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /label="yqfT gene" downshifts 2299244 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2299284..2300177) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" /label="nfo CDS" gene complement(2299284..2300177) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /label="nfo gene" S_feature 2299289..2300090 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2299305) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" /label="downshifts" CDS complement(2300187..2301503) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" /label="cshB CDS" gene complement(2300187..2301503) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /label="cshB gene" promotor_-10 complement(2301539..2301558) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2301550) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2301574..2301578) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2301607..2301616 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2301628 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2301630..2301649 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2301672..2302415 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" /label="yqfQ CDS" gene 2301672..2302415 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /label="yqfQ gene" downshifts 2302397 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" promotor_-35 2302419..2302426 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2302440..2302459 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2302442..2302537 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2302442 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="upshifts" CDS 2302538..2303482 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" /label="ispH CDS" gene 2302538..2303482 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /label="ispH gene" downshifts 2303453 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2303505..2304626) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" /label="yqfO CDS" gene complement(2303505..2304626) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /label="yqfO gene" downshifts complement(2303530) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2304619..2305269) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" /label="trmK CDS" gene complement(2304619..2305269) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /label="trmK gene" S_feature complement(2305270..2305378) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2305366..2305385) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2305378) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2305380..2305493) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2305401..2305405) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2305526..2305888) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" /label="cccA CDS" gene complement(2305526..2305888) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /label="cccA gene" downshifts complement(2305538) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-35 2305884..2305888 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2305896..2305910 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2305917 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2305925..2305944) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2305927) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2305929..2306050) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2305956..2305963) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2306039..2306058) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2306047..2306066 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2306050) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2306052..2306191) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2306053..2306157 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2306053 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2306072..2306078) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2306121..2306128 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2306142..2306161 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2306159..2308308 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2306159 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2306217..2307332) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" /label="sigA CDS" gene complement(2306217..2307332) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /label="sigA gene" downshifts complement(2306236) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" /label="downshifts" S_feature complement(2307333..2307530) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2307531..2309342) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" /label="dnaG CDS" gene complement(2307531..2309342) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /label="dnaG gene" promotor_-35 2308937..2308943 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2308953 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2308955..2308974 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2308982..2309278 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" /label="antE CDS" gene 2308982..2309278 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /label="antE gene" CDS complement(2309376..2309870) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" /label="yqxD CDS" gene complement(2309376..2309870) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /label="yqxD gene" promotor_-10 complement(2309843..2309861) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2309854) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2309871..2309984) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2309873..2309881) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2309879..2309884 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2309900..2309918 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2309915 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2309969..2309987) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2309984) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2309986..2310063) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2310003..2310008) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2310029..2310048) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2310063) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2310064..2310067) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2310124..2310936) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" /label="ppsR CDS" gene complement(2310124..2310936) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /label="ppsR gene" CDS complement(2310962..2311600) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" /label="ccpN CDS" gene complement(2310962..2311600) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /label="ccpN gene" S_feature complement(2311601..2311732) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2311726..2311745) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2311733..2313772) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" /label="glyS CDS" gene complement(2311733..2313772) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /label="glyS gene" upshifts complement(2311735) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2311760..2311767) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2311779) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" downshifts complement(2311845) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" /label="downshifts" CDS complement(2313765..2314652) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" /label="glyQ CDS" gene complement(2313765..2314652) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /label="glyQ gene" misc_RNA complement(2314735..2314909) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" /label="tboG RNA" gene complement(2314735..2314909) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /label="tboG gene" downshifts complement(2314769) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" /label="downshifts" promotor_-35 2314884..2314889 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2314905..2314923 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2314913..2314932) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2314915..2316327 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2314915 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2314925) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2314947..2314954) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2314949..2315716) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" /label="recO CDS" gene complement(2314949..2315716) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /label="recO gene" CDS complement(2315753..2315896) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" /label="yqzL CDS" gene complement(2315753..2315896) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /label="yqzL gene" S_feature complement(2315897..2316043) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2316044..2316949) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" /label="era CDS" gene complement(2316044..2316949) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /label="era gene" CDS complement(2316930..2317340) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" /label="cdd CDS" gene complement(2316930..2317340) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /label="cdd gene" promotor_-10 complement(2317378..2317397) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2317389) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2317391..2317458) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2317412..2317415) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2317459..2317830) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" /label="unpK CDS" gene complement(2317459..2317830) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /label="unpK gene" CDS complement(2317811..2318284) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" /label="rnrY CDS" gene complement(2317811..2318284) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /label="rnrY gene" CDS complement(2318285..2320420) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" /label="pgpH CDS" gene complement(2318285..2320420) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /label="pgpH gene" promotor_-35 2320264..2320269 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2320284 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2320285..2320303 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2320499..2321458) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" /label="phoH CDS" gene complement(2320499..2321458) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /label="phoH gene" downshifts complement(2320514) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" CDS complement(2321455..2322651) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" /label="yqfD CDS" gene complement(2321455..2322651) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /label="yqfD gene" promotor_-10 complement(2321522..2321541) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2321527) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2321555..2321562) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2321602..2321620) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2321614) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="upshifts" promotor_-35 complement(2321635..2321641) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2321829) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="upshifts" promotor_-10 complement(2321843..2321854) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2321869..2321875) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2322670..2322951) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" /label="yqfC CDS" gene complement(2322670..2322951) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /label="yqfC gene" CDS complement(2323008..2323427) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" /label="yqfB CDS" gene complement(2323008..2323427) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /label="yqfB gene" downshifts complement(2323022) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2323452..2324447) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" /label="floA CDS" gene complement(2323452..2324447) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /label="floA gene" CDS complement(2324469..2325782) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" /label="nfeDA CDS" gene complement(2324469..2325782) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /label="nfeDA gene" promotor_-10 complement(2325818..2325833) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2325835) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="upshifts" promotor_-35 complement(2325846..2325855) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2325913..2326359) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" /label="yqeY CDS" gene complement(2325913..2326359) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /label="yqeY gene" downshifts complement(2325926) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" downshifts complement(2326124) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(2326374..2326547) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" /label="rpsU CDS" gene complement(2326374..2326547) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /label="rpsU gene" misc_feature 2326483..2326487 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2326488 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2326608..2326627) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2326623) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2326641..2326648) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2326666..2326671 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2326686 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2326687..2326705 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2326720..2327643 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" /label="yqeW CDS" gene 2326720..2327643 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /label="yqeW gene" CDS complement(2327680..2329035) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" /label="mtaB CDS" gene complement(2327680..2329035) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /label="mtaB gene" downshifts complement(2327686) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2329035..2329805) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" /label="rsmE CDS" gene complement(2329035..2329805) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /label="rsmE gene" CDS complement(2329828..2330763) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" /label="prmA CDS" gene complement(2329828..2330763) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /label="prmA gene" CDS complement(2330788..2331915) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" /label="dnaJ CDS" gene complement(2330788..2331915) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /label="dnaJ gene" misc_feature 2331832..2331835 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2331843 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2331916..2332093) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2331955..2332045 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surC RNA" gene 2331955..2332045 /gene="surC" /locus_tag="BSU_misc_RNA_79" /label="surC gene" CDS complement(2332115..2333950) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" /label="dnaK CDS" gene complement(2332115..2333950) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /label="dnaK gene" downshifts complement(2332138) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" /label="downshifts" CDS complement(2333974..2334537) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" /label="grpE CDS" gene complement(2333974..2334537) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /label="grpE gene" S_feature complement(2334538..2334608) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2334609..2335640) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" /label="hrcA CDS" gene complement(2334609..2335640) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /label="hrcA gene" promotor_-10 complement(2335681..2335700) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2335694) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2335715..2335722) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2335721..2336860) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" /label="hemN CDS" gene complement(2335721..2336860) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /label="hemN gene" promotor_-10 complement(2336733..2336744) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2336737) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="upshifts" promotor_-35 complement(2336758..2336764) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2336913..2338751) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" /label="lepA CDS" gene complement(2336913..2338751) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /label="lepA gene" downshifts complement(2336935) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2338786..2338805) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2338803) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2338821..2338825) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2338885..2339223) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" /label="yqxA CDS" gene complement(2338885..2339223) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /label="yqxA gene" downshifts complement(2338891) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2339240..2340445) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" /label="spoIIP CDS" gene complement(2339240..2340445) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /label="spoIIP gene" promotor_-10 complement(2340465..2340483) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2340477) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2340499..2340504) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2340508..2341614) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" /label="gpr CDS" gene complement(2340508..2341614) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /label="gpr gene" promotor_-10 complement(2341642..2341653) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2341649) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2341668..2341674) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2341713..2341716 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2341729 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2341732..2341751 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2341743..2341817 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2341818..2342084 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" /label="rpsT CDS" gene 2341818..2342084 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /label="rpsT gene" downshifts 2342073 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2342099..2343142) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" /label="holA CDS" gene complement(2342099..2343142) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /label="holA gene" downshifts complement(2342144) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2343171..2343190) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2343182..2343331) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" /label="hypothetical protein CDS" gene complement(2343182..2343331) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /label="gene" upshifts complement(2343183) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2343204..2343208) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2343206..2343545) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2343249) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" /label="downshifts" promotor_-35 2343318..2343324 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2343338..2343357 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2343339 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="upshifts" CDS 2343372..2343506 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" /label="yqzM CDS" gene 2343372..2343506 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /label="yqzM gene" downshifts 2343500 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" /label="downshifts" CDS complement(2343546..2345876) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" /label="comEC CDS" gene complement(2343546..2345876) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /label="comEC gene" promotor_-10 complement(2343563..2343582) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2343579) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2343596..2343605) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2345880..2346449) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" /label="comEB CDS" gene complement(2345880..2346449) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /label="comEB gene" promotor_-10 complement(2346476..2346495) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2346486) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2346510..2346517) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2346516..2347133) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" /label="comEA CDS" gene complement(2346516..2347133) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /label="comEA gene" promotor_-35 2347154..2347159 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2347171 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2347175..2347193 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2347194..2347208) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2347196) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2347198..2348045) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2347217..2347221) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2347217..2348038 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" /label="comER CDS" gene 2347217..2348038 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /label="comER gene" promotor_-10 complement(2348033..2348052) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2348039..2348119 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2348046) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2348066..2348073) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2348079 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2348104..2348847) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" /label="yqeM CDS" gene complement(2348104..2348847) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /label="yqeM gene" downshifts complement(2348134) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2348844..2349200) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" /label="rsfS CDS" gene complement(2348844..2349200) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /label="rsfS gene" CDS complement(2349218..2349778) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" /label="yqeK CDS" gene complement(2349218..2349778) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /label="yqeK gene" CDS complement(2349768..2350337) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" /label="nadD CDS" gene complement(2349768..2350337) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /label="nadD gene" CDS complement(2350349..2350639) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" /label="yqeI CDS" gene complement(2350349..2350639) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /label="yqeI gene" CDS complement(2350633..2351475) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" /label="aroE CDS" gene complement(2350633..2351475) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /label="aroE gene" downshifts 2351467 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" /label="downshifts" CDS complement(2351493..2352593) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" /label="rgpH CDS" gene complement(2351493..2352593) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /label="rgpH gene" CDS complement(2352597..2353115) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" /label="yqeG CDS" gene complement(2352597..2353115) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /label="yqeG gene" promotor_-10 complement(2353025..2353042) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2353039) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2353058..2353061) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2353116..2353677) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2353149) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" /label="downshifts" promotor_-35 2353340..2353347 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2353358..2353458 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2353358..2353377 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2353358 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(2353408..2353666) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sdaM RNA" gene complement(2353408..2353666) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /label="sdaM gene" CDS 2353459..2353617 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" /label="sda CDS" gene 2353459..2353617 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /label="sda gene" S_feature 2353618..2353864 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2353665..2353684) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2353676) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2353700..2353704) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2353728..2353875) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2353765) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2353821 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 2353866..2354919 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2353870..2353889) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2353875) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2353902..2353911) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2353923..2354654) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipoprotein; putative esterase" /protein_id="NP_390447.1" /db_xref="EnsemblGenomes-Gn:BSU25700" /db_xref="EnsemblGenomes-Tr:CAB14511" /db_xref="GOA:P54451" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11634" /db_xref="UniProtKB/Swiss-Prot:P54451" /translation="MKHFIILFLLLFVTAGCEGRGYEDVVAFGDSNTRGSNWDYRDYP KAQQWVNILKTAERGNLDILNAGIGGQTTEDARLRFQTDVLDQKPKYLFIMFGTNDAA ILTEGKPRVSKQRFRENLVYFIEESRKHGIKPILMTCIPIIEGNGKHHLFYYSRYQAA AFEPKGGARKWHNSYNDITRDVSKRLDVPLVDNWKHFIEADGGKATDEALIQSGLIDP SGNHMTPKGARIVYEGIQDGQILQR*" /label="yqeF CDS" gene complement(2353923..2354654) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" /label="yqeF gene" promotor_-10 complement(2354673..2354692) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2354689) /Source="Nicolas_upshifts" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2354691..2354799) /Source="Nicolas_S_feature" /locus_tag="new_2648688_2648796_c" /HighExp="Etha, Salt, Gly, S8, C30, S7, LPhT, Sw, Heat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S970" promotor_-35 complement(2354706..2354712) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2354800..2354818) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2354821) /Source="Nicolas_upshifts" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2354833..2354838) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2354906..2355658) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" /EC_number="3.5.1.28" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10515909, 10974124, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10974124, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390448.1" /db_xref="EnsemblGenomes-Gn:BSU25710" /db_xref="EnsemblGenomes-Tr:CAB14512" /db_xref="GOA:P54450" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="SubtiList:BG11633" /db_xref="UniProtKB/Swiss-Prot:P54450" /translation="MVTIKKDFIPVSNDNRPGYAMAPAYITVHNTANTAKGADAKMHA KFVKNPNTSESWHFTVDDSVIYQHLPIDENGWHAGDGTNGTGNRKSIGIEICENADGD FEKATSNAQWLIRKLMKENNIPLNRVVPHKKWSGKECPRKLLDHWNSFLNGISSSDTP PKETSPSYPLPSGVIKLTSPYRKGTNILQLQKALAVLHFYPDKGAKNNGIDGVYGPKT ANAVKRFQLMNGLTADGIYGPKTKAKLKSKLK*" /label="cwlH CDS" gene complement(2354906..2355658) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" /label="cwlH gene" downshifts complement(2354909) /Source="Nicolas_upshifts" /id="D1331" /incds=0 /nref=4 /ntot=10 /MaxReadThrough="1.29819" /MaxDrop="4.65121" /score="4.6304411" /energy="-10.7" /TU="NA" /idTUdmin="U2003" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2355037..2355043 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2355057..2355075 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2355064 /Source="Nicolas_upshifts" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2355668..2355687) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2355687) /Source="Nicolas_upshifts" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2355701..2355709) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2355753..2355760 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2355775..2355794 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2355779..2355844 /Source="Nicolas_S_feature" /locus_tag="new_2649776_2649841" /HighExp="dia15, H2O2, C30, G180, Heat, S8, Paraq, Oxctl, LBGexp, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S971" upshifts 2355779 /Source="Nicolas_upshifts" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="upshifts" CDS 2355845..2356471 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 15855514, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390449.1" /db_xref="EnsemblGenomes-Gn:BSU25720" /db_xref="EnsemblGenomes-Tr:CAB14513" /db_xref="GOA:P54449" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG11632" /db_xref="UniProtKB/Swiss-Prot:P54449" /translation="MLKKVIGILVIIAIISVGFFQKEAWLDAIKAGGMFSVLFSMLLI AADVFFPIVPFALIAALNGAVFGTANGIWITLTGSMLGTILLFFLARYSFRDWARKKV QAYPAIQSYEASFNKNAFTAVLLGRLIPVIPSLVMNVICGLSQVRWHVFFFASLIGKI PNIVVVTIAGANFTSNKLLSISIYGTYILIIMLVIYKKFPHLLKVPKK*" /label="yqeD CDS" gene 2355845..2356471 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" /label="yqeD gene" downshifts 2356439 /Source="Nicolas_upshifts" /id="D1332" /incds=0 /nref=2 /ntot=63 /MaxReadThrough="2.9326" /MaxDrop="2.91074" /score="15.7108141" /energy="-10.3" /TU="U2004" /idTUdmin="U2004" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2356490..2357383) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10658669, 15231785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic 6-phospho-gluconate dehydrogenase (NAD[+]-dependent)" /protein_id="NP_390450.1" /db_xref="EnsemblGenomes-Gn:BSU25730" /db_xref="EnsemblGenomes-Tr:CAB14514" /db_xref="GOA:P54448" /db_xref="InterPro:IPR004849" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11631" /db_xref="UniProtKB/Swiss-Prot:P54448" /translation="MKIGLIGLGKMGINIGKQFIDRNHQVVGYDVNQAAVDELKAYGA EGTTNLKEFISLLHPPRILWVMVPHGIVDAVLRDVSPLLSKGDMIIEAGNSHYKESIR RYNQMKEAGIHYLDAGTSGGMEGARHGACFMVGGDHEAWEIVEPLFRDTAVENGYLYA GEAGSGHFLKMIHNGIEYGMMAAIGEGFEVLENSQFDFDYEKVARVWNHGSVIRSWLM GLTERAFAKDAKLDQIKGIMHSSGEGKWTVETALDLQTATPVIAMSLMMRYRSLTDDT FTGKVVAALRNEFGGHATEKK*" /label="yqeC CDS" gene complement(2356490..2357383) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" /label="yqeC gene" downshifts complement(2356515) /Source="Nicolas_upshifts" /id="D1333" /incds=0 /nref=4 /ntot=12 /MaxReadThrough="1.46947" /MaxDrop="3.03963" /score="0.698755756" /energy="-8.4" /TU="NA" /idTUdmin="U2003" /TUdmin="-1606" /isTUend="FALSE" /label="downshifts" promotor_-35 2357566..2357572 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2357584..2357603 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2357584 /Source="Nicolas_upshifts" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="upshifts" CDS 2357635..2358357 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390451.2" /db_xref="EnsemblGenomes-Gn:BSU25740" /db_xref="EnsemblGenomes-Tr:CAB14515" /db_xref="GOA:P54447" /db_xref="SubtiList:BG11630" /db_xref="UniProtKB/Swiss-Prot:P54447" /translation="MLQNQSHTLIGVTKTAVFFLYAALAIIGFAIGYFIPQIAKWALS LPWIPLEGPLRLITSFQGSTASFITALLGMCAGIWFAHSVIAMLLSVKITDHTVEFIK GKKVQTIHSDDIALVFMDHKRLVLLGTAGYELVREEIDEKPVNVEKAFRQHHYEWATD GDPFKDQFRRWIPDAPDLSQGAHALLKARHKALQDEEKDDIEEFRLELAQLGIVVRDE GTRQYWRKAETYPPKIQLGEGL*" /label="yqeB CDS" gene 2357635..2358357 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" /label="yqeB gene" CDS complement(2358390..2358800) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7746143, 17209033, 21179489" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746143, 17209033, 21179489; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific matrix degrading exported DNase" /protein_id="NP_390452.1" /db_xref="EnsemblGenomes-Gn:BSU25750" /db_xref="EnsemblGenomes-Tr:CAB14516" /db_xref="GOA:P42983" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG11237" /db_xref="UniProtKB/Swiss-Prot:P42983" /translation="MKKWMAGLFLAAAVLLCLMVPQQIQGASSYDKVLYFPLSRYPET GSHIRDAIAEGHPDICTIDRDGADKRREESLKGIPTKPGYDRDEWPMAVCEEGGAGAD VRYVTPSDNRGAGSWVGNQMSSYPDGTRVLFIVQ*" /label="nucB CDS" gene complement(2358390..2358800) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" /label="nucB gene" downshifts complement(2358415) /Source="Nicolas_upshifts" /id="D1334" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="0.80212" /MaxDrop="3.40706" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2006" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2358820..2358838) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2358822) /Source="Nicolas_upshifts" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2358854..2358859) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2358923..2358931 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2358944 /Source="Nicolas_upshifts" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2358945..2358964 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2358996..2359466 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (N-terminal half)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14517.2" /db_xref="SubtiList:BG10459" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MVTGVFAALGFVVKELVFLVSYVKNNAFPQPLSSSEEKKYLELM AKGDEHARNMLIEHNLRLVAHIVKKFENTGEDAEDLISIGTIGLIKGIESYSAGKGTK LATYAARCIENEIVITKGGCIHPSLIRFNIYGVRIHNGNFFHDKVNNCFFIFKS*" /label="sigKn CDS" gene 2358996..2359466 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /pseudo /label="sigKn gene" downshifts 2359186 /Source="Nicolas_upshifts" /id="D1335" /incds=1 /nref=2 /ntot=5 /MaxReadThrough="7.53734" /MaxDrop="3.01863" /score="-7.46047649" /energy="-12.1" /TU="U2007" /idTUdmin="U2007" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 2359318 /Source="Nicolas_upshifts" /id="D1336" /incds=1 /nref=44 /ntot=61 /MaxReadThrough="0.8049" /MaxDrop="7.21386" /score="-7.46047649" /energy="-12.1" /TU="NA" /idTUdmin="U2007" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2359374..2360876) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific DNA recombinase; skin element" /protein_id="NP_390454.2" /db_xref="EnsemblGenomes-Gn:BSU25770" /db_xref="EnsemblGenomes-Tr:CAB14518" /db_xref="GOA:P17867" /db_xref="InterPro:IPR006118" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG10458" /db_xref="UniProtKB/Swiss-Prot:P17867" /translation="MIAIYVRVSTEEQAIKGSSIDSQIEACIKKAGTKDVLKYADEGF SGELLERPALNRLREDASKGLISQVICYDPDRLSRKLMNQLIIDDELRKRNIPLIFVN GEYANSPEGQLFFAMRGAISEFEKAKIKERTSSGRLQKMKKGMIIKDSKLYGYKFVKE KRTLEILEEEAKIIRMIFNYFTDHKSPFFGRVNGIALHLTQMGVKTKKGAKVWHRQVV RQILMNSSYKGEHRQYKYDTEGSYVSKQAGNKSIIKIRPEEEQITVTIPAIVPAEQWD YAQELLGQSKRKHLSISPHNYLLSGLVRCGKCGNTMTGKKRKSHGKDYYVYTCRKNYS GAKDRGCGKEMSENKLNRHVWGEIFKFITNPQKYVSFKEAEQSNHLSDELELIEKEIE KTKKGRKRLLTLISLSDDDDLDIDEIKAQIIELQKKQNQLTEKCNEIQSKMKVLDDTS SSENALKRAIDYFQSIGADNLTLEDKKTIVNFIVKEVTIVDSDTIYIETY*" /label="spoIVCA CDS" gene complement(2359374..2360876) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" /label="spoIVCA gene" downshifts complement(2359390) /Source="Nicolas_upshifts" /id="D1337" /incds=1 /nref=21 /ntot=131 /MaxReadThrough="2.50085" /MaxDrop="6.35891" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2008" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2360983..2361001) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2361001) /Source="Nicolas_upshifts" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2361003..2361304) /Source="Nicolas_S_feature" /locus_tag="new_2655000_2655301_c" /HighExp="dia5, Diami, S8, S7, dia15, C30, G135, S6, G180, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.974" /TUlongSig="NA" /TUlongPSig="NA" /label="S972" promotor_-35 complement(2361018..2361023) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2361325..2361744) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" /EC_number="1.20.4.4" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin-coupled arsenate reductase; skin element" /protein_id="NP_390455.1" /db_xref="EnsemblGenomes-Gn:BSU25780" /db_xref="EnsemblGenomes-Tr:CAB14519" /db_xref="GOA:P45947" /db_xref="InterPro:IPR014064" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1JL3" /db_xref="PDB:1Z2D" /db_xref="PDB:1Z2E" /db_xref="PDB:2IPA" /db_xref="SubtiList:BG11304" /db_xref="UniProtKB/Swiss-Prot:P45947" /translation="MENKIIYFLCTGNSCRSQMAEGWAKQYLGDEWKVYSAGIEAHGL NPNAVKAMKEVGIDISNQTSDIIDSDILNNADLVVTLCGDAADKCPMTPPHVKREHWG FDDPARAQGTEEEKWAFFQRVRDEIGNRLKEFAETGK*" /label="arsC CDS" gene complement(2361325..2361744) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" /label="arsC gene" downshifts complement(2361349) /Source="Nicolas_upshifts" /id="D1338" /incds=0 /nref=106 /ntot=239 /MaxReadThrough="3.85143" /MaxDrop="6.98965" /score="17.1730317" /energy="-8.6" /TU="U2009" /idTUdmin="U2009" /TUdmin="-1823" /isTUend="FALSE" /label="downshifts" CDS complement(2361756..>2361884) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9537360, 15849754, 16850406, 16905151; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite efflux transporter; skin element" /protein_id="NP_390456.2" /db_xref="EnsemblGenomes-Gn:BSU25790" /db_xref="EnsemblGenomes-Tr:CAB14520" /db_xref="GOA:P45946" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004706" /db_xref="SubtiList:BG11303" /db_xref="UniProtKB/Swiss-Prot:P45946" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /translation="YRIHSGAAFAAVIGPLVEVPVMIALVKVALWFQRKYFGSHSM*" /label="Delta6_pseudo_BSU_25790" gene complement(2361756..>2361884) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /label="Delta6_pseudo_BSU_25790" SCAR join(2361880,2361887) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="TFC7A" N_region 2361881..2361886 /note="EcoRV side (GATATC)" /created_by="User" /modified_by="User" /label="TFC7A" CDS <2361882..2362268 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /inference="COORDINATES: similar to AA sequence:RefSeq:NP_390515.1" /note="incomplete; partial in the middle of a contig; missing N-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology." /pseudo /codon_start=1 /transl_table=11 /product="ImmA/IrrE family metallo-endopeptidase" /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /translation="ISSFALKHSGIYNICLDSRKSRTEQWYDFAHEFCHIYRHEGDKK TMPATWTDYLDWQSNYFTYHFCIPTCMLRNINLPYIQSHAIENVAWLFKVSPSFAKKR LSIYYRKLTQHLFSQTVTGNLCPPFL*" /label="Delta6_pseudo_BSU_26380" gene <2361882..2362268 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /pseudo /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /label="Delta6_pseudo_BSU_26380" misc_feature complement(2362235..2362253) /Source="Nicolas_upshift_promotors" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2362250..2362666 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2163341, 7704261, 8969508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2163341, 7704261, 8969508; Product type f: factor" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (C-terminal fragment)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14580.1" /db_xref="SubtiList:BG10919" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MPPLFVMNNEILMHLRALKKTKKDVSLHDPIGQDKEGNEISLID VLKSENEDVIDTIQLNMELEKVKQYIDILDDREKEVIVGRFGLDLKKEKTQREIAKEL GISRSYVSRIEKRALMKMFHEFYRAEKEKRKKAKGK*" /label="sigKc CDS" gene 2362250..2362666 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /pseudo /label="sigKc gene" misc_feature 2362255..2362269 /Source="Nicolas_upshift_promotors" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2362263) /Source="Nicolas_upshifts" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 2362274 /Source="Nicolas_upshifts" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" /label="upshifts" downshifts 2362650 /Source="Nicolas_upshifts" /id="D1357" /incds=0 /nref=50 /ntot=108 /MaxReadThrough="3.60274" /MaxDrop="5.60264" /score="-0.848064104" /energy="-4.5" /TU="U2035" /idTUdmin="U2033" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS 2362666..2362782 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513982.1" /translation="MQKKPDLILRLSLFERVMKIIFFIADKLSEKDRQDRNK*" /label="hypothetical protein CDS" gene 2362666..2362782 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" /label="gene" S_feature 2362695..2364029 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" downshifts complement(2362813) /Source="Nicolas_upshifts" /id="D1358" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="3.25265" /MaxDrop="3.18978" /score="3.17084908" /energy="-14.7" /TU="NA" /idTUdmin="U2036" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(2362891..2363055) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390517.1" /db_xref="EnsemblGenomes-Gn:BSU26400" /db_xref="EnsemblGenomes-Tr:CAB14581" /db_xref="SubtiList:BG11785" /db_xref="UniProtKB/Swiss-Prot:P54446" /translation="MKVIIIEGLQTDKCMNDCYHYLIKLYRQEIQGDSNISWNKRSRD RASTARSRPV*" /label="yrkS CDS" gene complement(2362891..2363055) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" /label="yrkS gene" promotor_-10 complement(2362985..2363004) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2363011) /Source="Nicolas_upshifts" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2363019..2363026) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2363189) /Source="Nicolas_upshifts" /id="D1359" /incds=0 /nref=79 /ntot=219 /MaxReadThrough="1.20909" /MaxDrop="4.40328" /score="39.3560776" /energy="-10.6" /TU="NA" /idTUdmin="U2036" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" CDS complement(2363600..2364016) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" /label="psiE CDS" gene complement(2363600..2364016) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /label="psiE gene" CDS complement(2364062..2365360) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" /label="yrkQ CDS" gene complement(2364062..2365360) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /label="yrkQ gene" CDS complement(2365347..2366042) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" /label="yrkP CDS" gene complement(2365347..2366042) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /label="yrkP gene" misc_feature complement(2366108..2366125) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2366117) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2366203..2366209 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2366216..2366234 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2366231 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2366310..2367527 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" /label="yrkO CDS" gene 2366310..2367527 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /label="yrkO gene" promotor_-35 2366769..2366776 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2366791..2366810 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2366807 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2367446..2367694 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" /label="hypothetical protein CDS" gene 2367446..2367694 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /label="gene" S_feature complement(2367623..2368670) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2368039..2368596 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" /label="yrkN CDS" gene 2368039..2368596 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /label="yrkN gene" S_feature 2368597..2368719 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2368672..2369086) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2368715) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" CDS complement(2369087..2369611) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" /label="yrkL CDS" gene complement(2369087..2369611) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /label="yrkL gene" promotor_-35 2369459..2369466 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2369477..2369496 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2369491 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2369612..2369699) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2369694..2369713) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2369699) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2369701..2369854) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2369728..2369735) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2369855..2370331) /gene="yrkK" /locus_tag="BSU_26480" /old_locus_tag="BSU26480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390525.2" /db_xref="EnsemblGenomes-Gn:BSU26480" /db_xref="EnsemblGenomes-Tr:CAB14589" /db_xref="GOA:P54438" /db_xref="InterPro:IPR025671" /db_xref="SubtiList:BG11777" /db_xref="UniProtKB/Swiss-Prot:P54438" /translation="MVYFVAFFCFAITLHNIEEAIWLPEWSQQSSKFQKPVTSNEFHF AVIVITMLAYLSAFGFLYMPESDIAKWIFIGFLGSMVINAIFPHLIATVVMKKYAPGL LTGLLLNIPVNSLVIYQMFLKNLIVWKELIISTLVVGIILLALIPLLFKVGDKVSP*" /label="yrkK CDS" gene complement(2369855..2370331) /gene="yrkK" /locus_tag="BSU_26480" /old_locus_tag="BSU26480" /label="yrkK gene" promotor_-10 complement(2370367..2370386) /Source="Nicolas_upshift_promotors" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2370381) /Source="Nicolas_upshifts" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2370383..2370913) /Source="Nicolas_S_feature" /locus_tag="new_2709471_2710001_c" /HighExp="Diami, dia15, S8, G180, Etha, G135, S6, S0, G150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S990" promotor_-35 complement(2370400..2370407) /Source="Nicolas_upshift_promotors" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2370914..2371699) /gene="yrkJ" /locus_tag="BSU_26490" /old_locus_tag="BSU26490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_390526.1" /db_xref="EnsemblGenomes-Gn:BSU26490" /db_xref="EnsemblGenomes-Tr:CAB14590" /db_xref="GOA:P54437" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG11776" /db_xref="UniProtKB/Swiss-Prot:P54437" /translation="MDIAFITTLFIIGFIGAFISGMIGIGGAVINYPMLLYIPSLVGV MSLTAHEVSGIGAIQVFFATLGGVWAYRKSGLINKTLIIYMGSSILLGSVLGSYFSHY ISEKGINFIYGILAIIAVILMFIPKKGQKGQEHSEDKEVIFNKWLASSLAFIIGGVSG ILGAGGAFILVPIMLSILNIPVRVTVASSLAITFLSSIGATVGKVITGQVLFVPALVL MITSLIASPIGASVGQKVNTKFLQWVLAQLIGATAIKIWLELL*" /label="yrkJ CDS" gene complement(2370914..2371699) /gene="yrkJ" /locus_tag="BSU_26490" /old_locus_tag="BSU26490" /label="yrkJ gene" CDS complement(2371760..2371987) /gene="yrkI" /locus_tag="BSU_26500" /old_locus_tag="BSU26500" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9555915; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur-carrier protein" /protein_id="NP_390527.1" /db_xref="EnsemblGenomes-Gn:BSU26500" /db_xref="EnsemblGenomes-Tr:CAB14591" /db_xref="GOA:P54436" /db_xref="InterPro:IPR001455" /db_xref="InterPro:IPR036868" /db_xref="SubtiList:BG11775" /db_xref="UniProtKB/Swiss-Prot:P54436" /translation="MKSDKVLDAKGLACPMPIVRTKKAMNELESGQILEVHATDKGAK NDLTAWSKSGGHDLLEQTDEGDILKFWIQKG*" /label="yrkI CDS" gene complement(2371760..2371987) /gene="yrkI" /locus_tag="BSU_26500" /old_locus_tag="BSU26500" /label="yrkI gene" downshifts complement(2371784) /Source="Nicolas_upshifts" /id="D1361" /incds=0 /nref=4 /ntot=22 /MaxReadThrough="5.31659" /MaxDrop="3.95633" /score="-3.35079978" /energy="-23.7" /TU="U2044,U2045" /idTUdmin="U2046" /TUdmin=3085 /isTUend="FALSE" /label="downshifts" CDS complement(2372021..2373154) /gene="yrkH" /locus_tag="BSU_26510" /old_locus_tag="BSU26510" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase / hydrolase" /protein_id="NP_390528.2" /db_xref="EnsemblGenomes-Gn:BSU26510" /db_xref="EnsemblGenomes-Tr:CAB14592" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036866" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11774" /db_xref="UniProtKB/Swiss-Prot:P54435" /translation="MKHDRKGNDPKRSDKKIFNKEPLFILDVRNENDFSDWKIEGHDF DHLNVPYFDLLDGVEDILEKIPSDKEVLVVCAKEGSSVMVSEMLSEAGHSVSYLKGGM KAWSEHLEPVKVGDLKDGGEMYQFVRIGKGCLSYMVISNGEAAIIDATRMVNFFIDFA KGKGATITHVFDTHLHADHISGGRVIAEKTKATYWLPPKDAEEVEFDYQPLEEGNDII IGNTTIKIQPIYSPGHTIGSTSFIVDDQYLLSGDILFIDSIGRPDLAGMAEDWVGDLR KTLYSRYKALSKDLIVLPAHFMIIDELNENGSVGKQLSTLFSENHGLNIADETEFRHL VTDHLPPQPNAYQEIRETNMGKISPDEEKQREMEIGPNRCAIR*" /label="yrkH CDS" gene complement(2372021..2373154) /gene="yrkH" /locus_tag="BSU_26510" /old_locus_tag="BSU26510" /label="yrkH gene" misc_feature complement(2372856..2372871) /Source="Nicolas_upshift_promotors" /id="U2043" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.410589410589411" /psig="0.477522477522478" /xcortree=1482 /SigmaFactorBS="aaaagaaggttcatccgtcatggtatccgaaatgctttctga agcaggtcattctgTATCCTACCTTAAGGGtggaatgaaagcatggagcgaacattta g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2372867) /Source="Nicolas_upshifts" /id="U2043" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.410589410589411" /psig="0.477522477522478" /xcortree=1482 /SigmaFactorBS="aaaagaaggttcatccgtcatggtatccgaaatgctttctga agcaggtcattctgTATCCTACCTTAAGGGtggaatgaaagcatggagcgaacattta g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2373155..2373488) /Source="Nicolas_S_feature" /locus_tag="new_2712243_2712576_c" /HighExp="Diami, dia15, Sw, BC, S0, G180, dia5, G135, M9-stat, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99950300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S991" CDS complement(2373489..2374046) /gene="yrkF" /locus_tag="BSU_26530" /old_locus_tag="BSU26530" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhodanese-related sulfur transferase" /protein_id="NP_390530.1" /db_xref="EnsemblGenomes-Gn:BSU26530" /db_xref="EnsemblGenomes-Tr:CAB14594" /db_xref="InterPro:IPR001455" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036868" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11772" /db_xref="UniProtKB/Swiss-Prot:P54433" /translation="MMKATIVLDAKGLACPMPIVKTKKRMKDLKAGEVLEIHATDKGS TADLEAWAKSTGHEYLGTEAEGEILRHFLRKGGEHSSENASSIPEISLEAFKQKVDSD ESLNILDVREIEEYEKAHIPGVVHIPLGEVEKRANELNENDEIYIICHSGRRSEMAAR TMKKQGFKKVINVVPGMRDWTGKTE*" /label="yrkF CDS" gene complement(2373489..2374046) /gene="yrkF" /locus_tag="BSU_26530" /old_locus_tag="BSU26530" /label="yrkF gene" S_feature complement(2374047..2374231) /Source="Nicolas_S_feature" /locus_tag="new_2713135_2713319_c" /HighExp="Diami, dia15, Sw, BC, S8, dia5, G180, S7, S0, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12629799999999999" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S992" CDS complement(2374232..2374714) /gene="yrkE" /locus_tag="BSU_26540" /old_locus_tag="BSU26540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein involved in sulfur metabolism (DsrE-like)" /protein_id="NP_390531.1" /db_xref="EnsemblGenomes-Gn:BSU26540" /db_xref="EnsemblGenomes-Tr:CAB14595" /db_xref="InterPro:IPR027396" /db_xref="InterPro:IPR032836" /db_xref="SubtiList:BG11771" /db_xref="UniProtKB/Swiss-Prot:P54432" /translation="MTEQTKRTTIVLFSGDYDKAMAAYIIANGAAAYDHEVTIFHTFW GFNALRKEELIPVKKGFLEKMFGKMMPRGADKMGLSKMNFAGMGPKMIKNVMKKHNVL TLPQLIEMAQEQGVKLVACTMTMDLLGLQEKELLDDIDYAGVAAYLADAEEGSVNLFI *" /label="yrkE CDS" gene complement(2374232..2374714) /gene="yrkE" /locus_tag="BSU_26540" /old_locus_tag="BSU26540" /label="yrkE gene" S_feature complement(2374715..2374823) /Source="Nicolas_S_feature" /locus_tag="new_2713803_2713911_c" /HighExp="Diami, dia15, Sw, BC, dia5, S8, G180, S6, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S993" CDS complement(2374861..2375052) /gene="yrkD" /locus_tag="BSU_26550" /old_locus_tag="BSU26550" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21339296; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative metal-sensitive transcriptional regulator involved in sulfur metabolism" /protein_id="NP_390532.1" /db_xref="EnsemblGenomes-Gn:BSU26550" /db_xref="EnsemblGenomes-Tr:CAB14596" /db_xref="GOA:P54431" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG11770" /db_xref="UniProtKB/Swiss-Prot:P54431" /translation="MMEQGKDCREVVTQLAASRNAIDRAMGLIVSTNLEHCVRESLEK GEDTQNLVKEAVDLLVKSR*" /label="yrkD CDS" gene complement(2374861..2375052) /gene="yrkD" /locus_tag="BSU_26550" /old_locus_tag="BSU26550" /label="yrkD gene" downshifts complement(2374868) /Source="Nicolas_upshifts" /id="D1362" /incds=0 /nref=153 /ntot=252 /MaxReadThrough="8.17686" /MaxDrop="5.42995" /score="-6.39526496" /energy="-7.9" /TU="U2044,U2045" /idTUdmin="U2046" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2375053..2375142) /Source="Nicolas_S_feature" /locus_tag="new_2714141_2714230_c" /HighExp="Diami, dia15, S6, S7, S8, Etha, dia5, S5, BC, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="1, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S994" CDS complement(2375143..2375460) /gene="yrzM" /locus_tag="BSU_26558" /old_locus_tag="BSU26558" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="PSEUDO:CAX52666.1" /translation="MIIIATYRRYYPITGISCIHKDKLEAMDITILDIRHYNDVANFS DNIILNIPYAYLKRFYLEIPRDKIHIIARDRVELNLGVRFLKRKGIHVNSYELATCKC KNK*" /label="yrzM CDS" gene complement(2375143..2375460) /gene="yrzM" /locus_tag="BSU_26558" /old_locus_tag="BSU26558" /pseudo /label="yrzM gene" promotor_-10 complement(2375249..2375268) /Source="Nicolas_upshift_promotors" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2375265) /Source="Nicolas_upshifts" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2375281..2375287) /Source="Nicolas_upshift_promotors" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2375502..2375717) /gene="yrzN" /locus_tag="BSU_26559" /old_locus_tag="BSU26559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52667.1" /translation="MINKADLKLNRLIALFEFLLAELALSNVSIFSIRGYRNESISSK KVTFTLDYIPMGVYYCFVNKQRVNKVV*" /label="yrzN CDS" gene complement(2375502..2375717) /gene="yrzN" /locus_tag="BSU_26559" /old_locus_tag="BSU26559" /pseudo /label="yrzN gene" promotor_-10 complement(2375530..2375549) /Source="Nicolas_upshift_promotors" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2375544) /Source="Nicolas_upshifts" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2375564..2375571) /Source="Nicolas_upshift_promotors" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2375718..2375844) /Source="Nicolas_S_feature" /locus_tag="new_2714806_2714932_c" /HighExp="S6, S7, S8, S5, BT, B36, G/S, BC, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.114547" /TUshortSig="SigK, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S995" CDS complement(2375845..2376405) /gene="yrkC" /locus_tag="BSU_26560" /old_locus_tag="BSU26560" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_390533.1" /db_xref="EnsemblGenomes-Gn:BSU26560" /db_xref="EnsemblGenomes-Tr:CAB14597" /db_xref="GOA:P54430" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG11769" /db_xref="UniProtKB/Swiss-Prot:P54430" /translation="MYYNPFSPQCYYYVTVPMYNDGRSVYWTIPNEMEKVHRGADLRS SYEDRNLLLKDYGPKPFVVNINRATKQNNTFRTALWTGKHFQVTLMSLGIGEDIGLEI HPNVDQFLRIEQGRGIVKMGKSKDHLNFQRNVYDDSAIVVPAGTWHNVINTGNTPLKL YSIYAPPNHPFGTVHETKADAVAAED*" /label="yrkC CDS" gene complement(2375845..2376405) /gene="yrkC" /locus_tag="BSU_26560" /old_locus_tag="BSU26560" /label="yrkC gene" CDS complement(2376422..2376598) /locus_tag="BSU_26569" /old_locus_tag="BSU26569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513984.1" /translation="MLTKASEIQHLENDYKVGDKLFIHESNGDRTFIFVFNMSFLDLA HSLNKCIGYYHKNL*" /label="hypothetical protein CDS" gene complement(2376422..2376598) /locus_tag="BSU_26569" /old_locus_tag="BSU26569" /label="gene" promotor_-10 complement(2376432..2376451) /Source="Nicolas_upshift_promotors" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2376443) /Source="Nicolas_upshifts" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2376445..2376630) /Source="Nicolas_S_feature" /locus_tag="new_2715533_2715718_c" /HighExp="BC, Sw, S3, dia15, Etha, S4, S5, H2O2, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.49093999999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S996" promotor_-35 complement(2376464..2376473) /Source="Nicolas_upshift_promotors" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2376631..2376777) /gene="yrkB" /locus_tag="BSU_26570" /old_locus_tag="BSU26570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390534.1" /db_xref="EnsemblGenomes-Gn:BSU26570" /db_xref="EnsemblGenomes-Tr:CAB14598" /db_xref="SubtiList:BG11768" /db_xref="UniProtKB/Swiss-Prot:P54429" /translation="MLLKNWPSRRIQRDKSKRAGIGGTNNRIPYTLLLCYVNVQKPFR IVDL*" /label="yrkB CDS" gene complement(2376631..2376777) /gene="yrkB" /locus_tag="BSU_26570" /old_locus_tag="BSU26570" /label="yrkB gene" CDS complement(2376947..2377768) /gene="bltR" /locus_tag="BSU_26580" /old_locus_tag="BSU26580" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7608059, 9083003, 10200972, 21954605" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7608059, 9083003, 10200972, 21954605; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (polyamine metabolism)" /protein_id="NP_390535.1" /db_xref="EnsemblGenomes-Gn:BSU26580" /db_xref="EnsemblGenomes-Tr:CAB14599" /db_xref="GOA:P39842" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="SubtiList:BG10904" /db_xref="UniProtKB/Swiss-Prot:P39842" /translation="MSEDVKKYFTTGEFSKLCRVKKQTLFHYDEIGLFSPEIKKENGY RYYSYHQFETFQVISLFKELGVPLKEIKCLIKGKTPDKILHVLKEKSIEIDKKINELK QLQTILQTKVTLTEQALETDFSSISFEYLNEETFMLSRKTLNLPERKYVAAISELIHE VQQYELDEGYPIGGIFAREQILEKDFYNYSYFYIKVKDGAENINYHVRPKGLYAVGYE IGGNTEEAYRRIIEFIERNGMQIGENAYEEYMLDEMVVDGYENTYAKILLQVKEV*" /label="bltR CDS" gene complement(2376947..2377768) /gene="bltR" /locus_tag="BSU_26580" /old_locus_tag="BSU26580" /label="bltR gene" promotor_-35 2377776..2377783 /Source="Nicolas_upshift_promotors" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2377778..2377797) /Source="Nicolas_upshift_promotors" /id="U2047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.966033966033966" /xcortree=1901 /SigmaFactorBS="tttttacctatccttttcgcttgaagcttttttcaagtacaa tcaaatcataaggtatATGGTTACCGTATAGTCAAGgaggtttttatgagcgaagatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2377795) /Source="Nicolas_upshifts" /id="U2047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.966033966033966" /xcortree=1901 /SigmaFactorBS="tttttacctatccttttcgcttgaagcttttttcaagtacaa tcaaatcataaggtatATGGTTACCGTATAGTCAAGgaggtttttatgagcgaagatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2377797..2379801) /Source="Nicolas_S_feature" /locus_tag="new_2716885_2718889_c" /HighExp="BC, Sw, Salt, Mal, T4.0H, M9-stat, T3.30H, G180, G135, MG 5" /AntisenseName="blt" /AntisenseCor="0.56943492854420497" /AntisenseRegPval="-23.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S997" promotor_-10 2377799..2377818 /Source="Nicolas_upshift_promotors" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2377807 /Source="Nicolas_upshifts" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="upshifts" CDS 2377885..2379087 /gene="blt" /locus_tag="BSU_26590" /old_locus_tag="BSU26590" /function="16.1: Circulate" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9083003, 10200972, 10359661, 12793527, 15849754, 16850406, 19114526, 21954605" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9083003, 10200972, 10359661, 12793527, 15849754, 16850406, 19114526, 21954605; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (promiscuous, acetylated polyamines efflux)" /protein_id="NP_390536.1" /db_xref="EnsemblGenomes-Gn:BSU26590" /db_xref="EnsemblGenomes-Tr:CAB14600" /db_xref="GOA:P39843" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR004734" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10905" /db_xref="UniProtKB/Swiss-Prot:P39843" /translation="MKKSINEQKTIFIILLSNIFVAFLGIGLIIPVMPSFMKIMHLSG STMGYLVAAFAISQLITSPFAGRWVDRFGRKKMIILGLLIFSLSELIFGLGTHVSIFY FSRILGGVSAAFIMPAVTAYVADITTLKERSKAMGYVSAAISTGFIIGPGAGGFIAGF GIRMPFFFASAIALIAAVTSVFILKESLSIEERHQLSSHTKESNFIKDLKRSIHPVYF IAFIIVFVMAFGLSAYETVFSLFSDHKFGFTPKDIAAIITISSIVAVVIQVLLFGKLV NKLGEKRMIQLCLITGAILAFVSTVMSGFLTVLLVTCFIFLAFDLLRPALTAHLSNMA GNQQGFVAGMNSTYTSLGNIFGPALGGILFDLNIHYPFLFAGFVMIVGLGLTMVWKEK KNDAAALN*" /label="blt CDS" gene 2377885..2379087 /gene="blt" /locus_tag="BSU_26590" /old_locus_tag="BSU26590" /label="blt gene" CDS 2379256..2379714 /gene="bltD" /locus_tag="BSU_26600" /old_locus_tag="BSU26600" /EC_number="2.3.1.57" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10200972, 10359661, 12793527, 9083003, 16210326, 21954605, 28197687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10359661, 12793527, 9083003, 16210326, 21954605, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermine/spermidine acetyltransferase" /protein_id="NP_390537.1" /db_xref="EnsemblGenomes-Gn:BSU26600" /db_xref="EnsemblGenomes-Tr:CAB14601" /db_xref="GOA:P39909" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027455" /db_xref="SubtiList:BG10906" /db_xref="UniProtKB/Swiss-Prot:P39909" /translation="MSINIKAVTDDNRAAILDLHVSQNQLSYIESTKVCLEDAKECHY YKPVGLYYEGDLVGFAMYGLFPEYDEDNKNGRVWLDRFFIDERYQGKGLGKKMLKALI QHLAELYKCKRIYLSIFENNIHAIRLYQRFGFQFNGELDFNGEKVMVKEL*" /label="bltD CDS" gene 2379256..2379714 /gene="bltD" /locus_tag="BSU_26600" /old_locus_tag="BSU26600" /label="bltD gene" downshifts complement(2379846) /Source="Nicolas_upshifts" /id="D1363" /incds=0 /nref=77 /ntot=211 /MaxReadThrough="5.09534" /MaxDrop="4.8114" /score="-0.00168005652" /energy="-10.7" /TU="U2049" /idTUdmin="U2051" /TUdmin=3845 /isTUend="FALSE" /label="downshifts" CDS complement(2379871..2381175) /gene="yrkA" /locus_tag="BSU_26610" /old_locus_tag="BSU26610" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative membrane associated protein" /protein_id="NP_390538.1" /db_xref="EnsemblGenomes-Gn:BSU26610" /db_xref="EnsemblGenomes-Tr:CAB14602" /db_xref="GOA:P54428" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11767" /db_xref="UniProtKB/Swiss-Prot:P54428" /translation="MTTINLIIFTLLIVLTAFFVATEFAIVKIRSSKIDQLILEGKKG AISAKKVITHLDEYLSACQLGITVTALGIGWVGESTFEVILHPLFAHFHVSETVSHVL ILVIAFVMATFLHVVVGELAPKTLAIQKAETITLLTAKPIIWFYRILFPFIWFLNGSA RFIVGLFGLKPASEHELAHSEEELRILLSESYKSGEINQNELKYVNNIFEFDERIAKE IMIPRREIVAISSEDSYETIVKIIKTESYTRYPVLNGDKDSIIGFINAKEFLSAYIDT DQKIKEDFKLENHINPVIHVIESVPIHDVLVKMQKERTHIAILVDEYGGTSGLVTAED ILEEIVGEIRDEFDKDEVPNIRKVNDNHYILDSKVLIEDVNDLLGTTLASDEVDTIGG WFMTQQIDAAVGSVIEADGYIFKVHETVGRHINYLEIVRKKE*" /label="yrkA CDS" gene complement(2379871..2381175) /gene="yrkA" /locus_tag="BSU_26610" /old_locus_tag="BSU26610" /label="yrkA gene" S_feature complement(2381176..2381255) /Source="Nicolas_S_feature" /locus_tag="new_2720264_2720343_c" /HighExp="BC, Sw, MG 15, Mal, Salt, MG 25, MG-0.2, MG 45, MG 5, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S998" promotor_-10 complement(2381241..2381260) /Source="Nicolas_upshift_promotors" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2381255) /Source="Nicolas_upshifts" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2381275..2381282) /Source="Nicolas_upshift_promotors" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2381438..2381581) /gene="yrzO" /locus_tag="BSU_26619" /old_locus_tag="BSU26619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097765.1" /db_xref="EnsemblGenomes-Gn:BSU26619" /db_xref="EnsemblGenomes-Tr:CAX52668" /db_xref="InterPro:IPR025417" /db_xref="UniProtKB/Swiss-Prot:C0H458" /translation="MFEGLLFFISAGIVCELAAINRNGRKNIKQQAELIQILKENLYK DIK*" /label="yrzO CDS" gene complement(2381438..2381581) /gene="yrzO" /locus_tag="BSU_26619" /old_locus_tag="BSU26619" /label="yrzO gene" CDS complement(2381599..2382564) /gene="yrdR" /locus_tag="BSU_26620" /old_locus_tag="BSU26620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390539.1" /db_xref="EnsemblGenomes-Gn:BSU26620" /db_xref="EnsemblGenomes-Tr:CAB14603" /db_xref="GOA:O07086" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12289" /db_xref="UniProtKB/Swiss-Prot:O07086" /translation="MKKGQLFIGALTCLVASMSWGAMFPVADHALEFVDPFYFSFIRY GVVTIMLVILLLVREGKKSFHLEGKAKWIILFGVMAFTIYNVLIFLGQRLMGKSGIMT ASIAEALMPMLSIVILWGYKHVKPKKYTMISILIAFLGASMVITKGNISFFFSLGDHL FSILFIFIGVLGWVVYTMGGQIFREWSTLRYSTLTCLFGTAITGIMTAILTAQGYVSV PSIKVIAAIKYDFLFMITLPGIIALLSWNYGIKILSSINGILFINFVPITTLLIMVIK GYNITAFDIVGTLFVIIGLILNNIYQRKEDYKQVLQKEKTNLTIT*" /label="yrdR CDS" gene complement(2381599..2382564) /gene="yrdR" /locus_tag="BSU_26620" /old_locus_tag="BSU26620" /label="yrdR gene" promotor_-35 2382602..2382605 /Source="Nicolas_upshift_promotors" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2382620..2382639 /Source="Nicolas_upshift_promotors" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2382647 /Source="Nicolas_upshifts" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="upshifts" CDS 2382690..2383556 /gene="czcR" /locus_tag="BSU_26630" /old_locus_tag="BSU26630" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 22666466, 25437189; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_390540.1" /db_xref="EnsemblGenomes-Gn:BSU26630" /db_xref="EnsemblGenomes-Tr:CAB14604" /db_xref="GOA:P71025" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12288" /db_xref="UniProtKB/Swiss-Prot:P71025" /translation="MELRDLQIFKCVAHHKSITGAAKELNYVQSNVTARIKQLENELK TPLFNRHKKGVSLSPEGRKMIEYVNKILKDVEELEQVFLDTEIPSGILKIGTVETVRI LPTIIASYYKKYPNVDLSLQAGLTEELIKKVMNHELDGAFISGPLKHSILEQYDVYTE KLTLVTSNKTFNIEDFSTTPILVFNQGCGYRSRLEQWLKDEGVLPNRMMEFNILETIL NSVALGLGITVVPESAVMHLAVQGKVYCHPLPEKDSCISTIFIRHKDAYLTNSMRSLL KTIVEHKNMSMA*" /label="czcR CDS" gene 2382690..2383556 /gene="czcR" /locus_tag="BSU_26630" /old_locus_tag="BSU26630" /label="czcR gene" S_feature 2383557..2383657 /Source="Nicolas_S_feature" /locus_tag="new_2722645_2722745" /HighExp="HiTm, dia15, LBGstat, LPhT, T0.30H, Diami, Paraq, dia5, H2O2, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.905" /TUlongSig="NA" /TUlongPSig="NA" /label="S999" downshifts 2383615 /Source="Nicolas_upshifts" /id="D1364" /incds=0 /nref=6 /ntot=135 /MaxReadThrough="2.57006" /MaxDrop="3.43983" /score="-6.36950065" /energy="-7" /TU="NA" /idTUdmin="U2050" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2383679..2384716) /gene="yrdP" /locus_tag="BSU_26640" /old_locus_tag="BSU26640" /EC_number="1.14.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099864, 12100555, 12527699; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_390541.1" /db_xref="EnsemblGenomes-Gn:BSU26640" /db_xref="EnsemblGenomes-Tr:CAB14605" /db_xref="GOA:O07085" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR000960" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11980" /db_xref="UniProtKB/Swiss-Prot:O07085" /translation="MYDTIVIGAGQAGISIGYYLKQSDQKFIILDKSHEVGESWKDRY DSLVLFTSRMYSSLPGMHLEGEKHGFPSKNEIVAYLKKYVKKFEIPIQLRTEVISVLK IKNYFLIKTNREEYQTKNLVIATGPFHTPNIPSISKDLSDNINQLHSSQYKNSKQLAY GNVLVVGGGNSGAQIAVELSKERVTYLACSNKLVYFPLMIGKRSIFWWFDKLGVLHAS HTSIVGKFIQKKGDPVFGHELKHAIKQKEIILKKRVIAAKQNEIIFKDSSTLEVNNII WATGFRNPLCWINIKGVLDQEGRIIHHRGVSPVEGLYFIGLPWQHKRGSALLQGVGND AEYIVKQMNGE*" /label="yrdP CDS" gene complement(2383679..2384716) /gene="yrdP" /locus_tag="BSU_26640" /old_locus_tag="BSU26640" /label="yrdP gene" downshifts complement(2383691) /Source="Nicolas_upshifts" /id="D1365" /incds=0 /nref=30 /ntot=134 /MaxReadThrough="2.50972" /MaxDrop="5.83595" /score="2.19797168" /energy="-12.5" /TU="NA" /idTUdmin="U2051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2384717..2384803) /Source="Nicolas_S_feature" /locus_tag="new_2723805_2723891_c" /HighExp="LBGtran, dia5, Gly, Diami, LBGstat, M0t45, LBGexp, Lbtran, dia0, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.907, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1000" CDS complement(2384804..2385739) /gene="czcD" /locus_tag="BSU_26650" /old_locus_tag="BSU26650" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10735849, 12100555, 15849754, 15948947, 16850406, 22447126, 26787764, 27210016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 12100555, 15849754, 15948947, 16850406, 22447126, 26787764, 27210016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium/proton-divalent cation antiporter" /protein_id="NP_390542.1" /db_xref="EnsemblGenomes-Gn:BSU26650" /db_xref="EnsemblGenomes-Tr:CAB14606" /db_xref="GOA:O07084" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11931" /db_xref="UniProtKB/Swiss-Prot:O07084" /translation="MGHNHNEGANKKVLLISFIMITGYMIIEAIGGFLTNSLALLSDA GHMLSDSISLMVALIAFTLAEKKANHNKTFGYKRFEILAAVINGAALILISLYIIYEA IERFSNPPKVATTGMLTISIIGLVVNLLVAWIMMSGGDTKNNLNIRGAYLHVISDMLG SVGAILAAILIIFFGWGWADPLASIIVAILVLRSGYNVTKDSIHILMEGTPENIDVSD IIRTIEGTEGIQNIHDLHIWSITSGLNALSCHAVVDDQLTISESENILRKIEHELEHK GITHVTIQMETEAHNHDNAILCQPKMEKQRDHHHH*" /label="czcD CDS" gene complement(2384804..2385739) /gene="czcD" /locus_tag="BSU_26650" /old_locus_tag="BSU26650" /label="czcD gene" promotor_-10 complement(2385774..2385793) /Source="Nicolas_upshift_promotors" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2385781) /Source="Nicolas_upshifts" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2385783..2385866) /Source="Nicolas_S_feature" /locus_tag="new_2724871_2724954_c" /HighExp="dia5, Gly, LBGtran, Diami, LBGstat, LBGexp, LoTm, dia0, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1001" promotor_-35 complement(2385808..2385815) /Source="Nicolas_upshift_promotors" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2385847..2385866) /Source="Nicolas_upshift_promotors" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2385866) /Source="Nicolas_upshifts" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2385880..2385887) /Source="Nicolas_upshift_promotors" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2386001) /Source="Nicolas_upshifts" /id="D1366" /incds=0 /nref=1 /ntot=41 /MaxReadThrough="3.75163" /MaxDrop="3.57795" /score="38.5313506" /energy="-18.1" /TU="NA" /idTUdmin="U2051" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS complement(2386026..2386415) /gene="yrdN" /locus_tag="BSU_26660" /old_locus_tag="BSU26660" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_390543.1" /db_xref="EnsemblGenomes-Gn:BSU26660" /db_xref="EnsemblGenomes-Tr:CAB14607" /db_xref="GOA:P94502" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG12287" /db_xref="UniProtKB/Swiss-Prot:P94502" /translation="MPLLRFDLIEGRDQSSLKKLLDVAHNVVVEAFDVPQQDRYQIVH EHPENHMIIEDTGLGFNRTKNLVVLSVTSKSRPEEKKQKFYRLLAERLESECGIASTD LIVSIVENDNADWSFGLGEAQFLTGKL*" /label="yrdN CDS" gene complement(2386026..2386415) /gene="yrdN" /locus_tag="BSU_26660" /old_locus_tag="BSU26660" /label="yrdN gene" promotor_-35 2386663..2386670 /Source="Nicolas_upshift_promotors" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2386686..2386705 /Source="Nicolas_upshift_promotors" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2386695 /Source="Nicolas_upshifts" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="upshifts" CDS 2386749..2387639 /gene="gltR" /locus_tag="BSU_26670" /old_locus_tag="BSU26670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023181, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023181, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_390544.2" /db_xref="EnsemblGenomes-Gn:BSU26670" /db_xref="EnsemblGenomes-Tr:CAB14608" /db_xref="GOA:P94501" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11942" /db_xref="UniProtKB/Swiss-Prot:P94501" /translation="MNIQLLQVFLTTAREGSISKAALTLNYAQSNVTNKIQQLENDLQ TKLFYRHSRGITLTPPGQILVSYSEKILHTIEEARAAMGESSAPSGPLRIGSMETTAA VWLPQLLAHYNNLYPNVDLNLVTGPTEQQIQAVLHYELNGAFISGPIEHPDLVQEKVL DEEMVLVTSASHPVISSIQDVQTQTMLVFRKGCSYRAKLNHILQEEGLLPIKLMEFGI LEAIIGCVSAGLGISLLPRSIIASHEKEGRIRSHTISDKYSFVSTMFIRRKDTLITPA LSAFLTHMRDHFQIKRPDQS*" /label="gltR CDS" gene 2386749..2387639 /gene="gltR" /locus_tag="BSU_26670" /old_locus_tag="BSU26670" /label="gltR gene" promotor_-35 2387327..2387332 /Source="Nicolas_upshift_promotors" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2387348..2387366 /Source="Nicolas_upshift_promotors" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2387355 /Source="Nicolas_upshifts" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2387797..2388114) /gene="yrdK" /locus_tag="BSU_26680" /old_locus_tag="BSU26680" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390545.3" /db_xref="EnsemblGenomes-Gn:BSU26680" /db_xref="EnsemblGenomes-Tr:CAB14609" /db_xref="SubtiList:BG12286" /db_xref="UniProtKB/Swiss-Prot:P94500" /translation="MRLYTEYIPNKNKLINQQQYHSDLQDLLHQWILQLLQLDVLPLS NRKYQSSRCHPKSVGEYLIVVRAIDALGNSQPLTSRRNQVSRAMTFVQNSLNEENLHP NID*" /label="yrdK CDS" gene complement(2387797..2388114) /gene="yrdK" /locus_tag="BSU_26680" /old_locus_tag="BSU26680" /label="yrdK gene" CDS complement(2388072..2389394) /gene="brnQ" /locus_tag="BSU_26690" /old_locus_tag="BSU26690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8544834, 9287000, 9531631, 15849754, 16850406, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8544834, 9287000, 9531631, 15849754, 16850406, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="low-affinity branched-chain amino acid transporter" /protein_id="NP_390546.1" /db_xref="EnsemblGenomes-Gn:BSU26690" /db_xref="EnsemblGenomes-Tr:CAB14610" /db_xref="GOA:P94499" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG11918" /db_xref="UniProtKB/Swiss-Prot:P94499" /translation="MSKKVSASYIIIIGLMLFALFFGAGNLIFPPMLGQLAGKNVWVA NAGFLVTGVGLPLLAITAFVFSGKQNLQSLASRVHPVFGIVFTTILYLAIGPFFAIPR SGNVSFEIGVKPFLSNDASPVSLIIFTILFFALACLLSLNPSKIIDIVGKFLTPIKLT FIGLLVAVALIRPIGTIQAPSKGYTSQAFFKGFQEGYLTLDALVAFVFGIIIVNALKE QGASTKKQLIVVCAKAAAIAAVLLAVMYTALSYMGASSVEELGILENGAEVLAKVSSY YFGSYGSILLGLMITVACLTTSVGLITACSSFFHELFPNISYKKIAVVLSVFSTLVAN IGLTQLIKVSMPVLLTMYPIAISLIFLTFLHSVFKGKTEVYQGSLLFAFIISLFDGLK AAGIKIEVVNRIFTQILPMYNIGLGWLIPAIAGGICGYILSIFRTKTS*" /label="brnQ CDS" gene complement(2388072..2389394) /gene="brnQ" /locus_tag="BSU_26690" /old_locus_tag="BSU26690" /label="brnQ gene" CDS complement(2389559..2389891) /gene="azlD" /locus_tag="BSU_26700" /old_locus_tag="BSU26700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9287000, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287000, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid / methionine exporter" /protein_id="NP_390547.1" /db_xref="EnsemblGenomes-Gn:BSU26700" /db_xref="EnsemblGenomes-Tr:CAB14611" /db_xref="GOA:O07923" /db_xref="InterPro:IPR008407" /db_xref="SubtiList:BG11916" /db_xref="UniProtKB/Swiss-Prot:O07923" /translation="MTMTMTQQMITIAMVVLGTMLTRFLPFMIFPSGKPTPKYVQYLG KVLPSAVIGLLVIYCLKDVSLLSGSHGIPELVGAAAVVLLHLWKKNMLLSIAGGTVVY MVLVQLVF*" /label="azlD CDS" gene complement(2389559..2389891) /gene="azlD" /locus_tag="BSU_26700" /old_locus_tag="BSU26700" /label="azlD gene" CDS complement(2389888..2390652) /gene="azlC" /locus_tag="BSU_26710" /old_locus_tag="BSU26710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9287000, 15849754, 16850406, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287000, 15849754, 16850406, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid / methionine exporter" /protein_id="NP_390548.1" /db_xref="EnsemblGenomes-Gn:BSU26710" /db_xref="EnsemblGenomes-Tr:CAB14612" /db_xref="GOA:O07942" /db_xref="InterPro:IPR004471" /db_xref="InterPro:IPR011606" /db_xref="SubtiList:BG11915" /db_xref="UniProtKB/Swiss-Prot:O07942" /translation="MNKNKESLHLSSPAINTHMNKRSQIWAAFRSAFPYTIPIFAGFL FLGIAYGIFMHSLGFSAIYPIIMSFMIFAGSMEFVAANFLLGAFNPMNALFLTLMVNA RHLFYGISMLDKYRGTGKKKLYLIFGMCDESFSINYTANVPANVDKGWFMFFVTLLNH LYWVAGAAIGGIFGSYVKFNTEGLDFVMTALFIVIFIEQWMKEKKHYSALTGLGLSVA SLILFGGNQFIIPAMLAILGVLTVLRKPLEKAEVSV*" /label="azlC CDS" gene complement(2389888..2390652) /gene="azlC" /locus_tag="BSU_26710" /old_locus_tag="BSU26710" /label="azlC gene" CDS complement(2390665..2391138) /gene="azlB" /locus_tag="BSU_26720" /old_locus_tag="BSU26720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023181, 9287000, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023181, 9287000, 26473603; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the azlBCD operon" /protein_id="NP_390549.1" /db_xref="EnsemblGenomes-Gn:BSU26720" /db_xref="EnsemblGenomes-Tr:CAB14613" /db_xref="GOA:O07920" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11914" /db_xref="UniProtKB/Swiss-Prot:O07920" /translation="MGIMLDETDKAILRDLQEDASISNLNLSKKIGLSPSACLARTKN LVEAGIIKKFTTIVDEKKLGIEVTALALINLSPLNRETIHSFLEDINKFPQVQECYTL TGSHDYMLKIVAKDMESYRNFIIDSLMQNPAISGVDTSIVMSTEKRTVSVPIDEM*" /label="azlB CDS" gene complement(2390665..2391138) /gene="azlB" /locus_tag="BSU_26720" /old_locus_tag="BSU26720" /label="azlB gene" CDS complement(2391472..2391747) /gene="yrdF" /locus_tag="BSU_26730" /old_locus_tag="BSU26730" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative ribonuclease inhibitor" /protein_id="NP_390550.1" /db_xref="EnsemblGenomes-Gn:BSU26730" /db_xref="EnsemblGenomes-Tr:CAB14614" /db_xref="GOA:O07938" /db_xref="InterPro:IPR000468" /db_xref="InterPro:IPR035905" /db_xref="SubtiList:BG12285" /db_xref="UniProtKB/Swiss-Prot:O07938" /translation="MRKIIIDGRDFENIEVLHDDLKDKLDFPDYYGRNLDALWDCLTG WVDLPLTLVLKNFEFSNTFLGSYADDVLEVIQEAQEELKDEFKIIIE*" /label="yrdF CDS" gene complement(2391472..2391747) /gene="yrdF" /locus_tag="BSU_26730" /old_locus_tag="BSU26730" /label="yrdF gene" misc_feature complement(2391759..2391778) /Source="Nicolas_upshift_promotors" /id="U2055" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.972027972027972" /xcortree=3056 /SigmaFactorBS="ttttcagcctcatttggacaaacagctgttacatagtaaacg tttgtTAAGATAAAATAATGGAGGGcatagtttctaatgagaaaaataataatagatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2391765) /Source="Nicolas_upshifts" /id="U2055" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.972027972027972" /xcortree=3056 /SigmaFactorBS="ttttcagcctcatttggacaaacagctgttacatagtaaacg tttgtTAAGATAAAATAATGGAGGGcatagtttctaatgagaaaaataataatagatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2391833..2392018) /Source="Nicolas_S_feature" /locus_tag="new_2730921_2731106_c" /HighExp="BT, S4, S8, S3, S5, S7, S6, LoTm, B36, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S1002" CDS complement(2392019..2393251) /gene="cypA" /locus_tag="BSU_26740" /old_locus_tag="BSU26740" /EC_number="1.14.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9778370, 12354229, 28898812" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9778370, 12354229, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450" /protein_id="NP_390551.1" /db_xref="EnsemblGenomes-Gn:BSU26740" /db_xref="EnsemblGenomes-Tr:CAB14615" /db_xref="GOA:O08469" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG11929" /db_xref="UniProtKB/Swiss-Prot:O08469" /translation="MSSKEKKSVTILTESQLSSRAFKDEAYEFYKELRKSQALYPLSL GALGKGWLISRYDDAIHLLKNEKLKKNYENVFTAKEKRPALLKNEETLTKHMLNSDPP DHNRLRTLVQKAFTHRMILQLEDKIQHIADSLLDKVQPNKFMNLVDDYAFPLPIIVIS EMLGIPLEDRQKFRVWSQAIIDFSDAPERLQENDHLLGEFVEYLESLVRKKRREPAGD LISALIQAESEGTQLSTEELYSMIMLLIVAGHETTVNLITNMTYALMCHHDQLEKLRQ QPDLMNSAIEEALRFHSPVELTTIRWTAEPFILHGQEIKRKDVIIISLASANRDEKIF PNADIFDIERKNNRHIAFGHGNHFCLGAQLARLEAKIAISTLLRRCPNIQLKGEKKQM KWKGNFLMRALEELPISF*" /label="cypA CDS" gene complement(2392019..2393251) /gene="cypA" /locus_tag="BSU_26740" /old_locus_tag="BSU26740" /label="cypA gene" CDS complement(2393301..2393459) /gene="yrdDc" /locus_tag="BSU_26748" /old_locus_tag="BSU26748" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; C-terminal part of YrdD" /db_xref="PSEUDO:CAX52669.1" /translation="MEVLGVSPFYQGKSLGSKMINDCLISFISKCGDGILALIMNTDL NGSFYKSS*" /label="yrdDc CDS" gene complement(2393301..2393459) /gene="yrdDc" /locus_tag="BSU_26748" /old_locus_tag="BSU26748" /pseudo /label="yrdDc gene" CDS complement(2393456..2393659) /gene="yrdDm" /locus_tag="BSU_26749" /old_locus_tag="BSU26749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; internal part of YrdD" /db_xref="SubtiList:BG12284" /translation="MHKVLTRAYFKKHFFFVGIQNGEMVVAALLKHRDKPDIKLDRLY SSRGDNINQNGAKKFSKSLKEPA*" /label="yrdDm CDS" gene complement(2393456..2393659) /gene="yrdDm" /locus_tag="BSU_26749" /old_locus_tag="BSU26749" /pseudo /label="yrdDm gene" promotor_-10 complement(2393620..2393638) /Source="Nicolas_upshift_promotors" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2393637) /Source="Nicolas_upshifts" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2393644..2393793) /gene="yrdDn" /locus_tag="BSU_26750" /old_locus_tag="BSU26750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; N-terminal part of YrdD" /db_xref="SubtiList:BG14036" /translation="MFLYRQARADEVSKVAKLFHQSFNQYPFMDLLVKREKKIIHLFL KCIKY*" /label="yrdDn CDS" gene complement(2393644..2393793) /gene="yrdDn" /locus_tag="BSU_26750" /old_locus_tag="BSU26750" /pseudo /label="yrdDn gene" promotor_-35 complement(2393653..2393658) /Source="Nicolas_upshift_promotors" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2393877) /Source="Nicolas_upshifts" /id="D1367" /incds=0 /nref=140 /ntot=216 /MaxReadThrough="2.2276" /MaxDrop="4.5127" /score="5.01317133" /energy="-16.7" /TU="NA" /idTUdmin="U2057" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2393892..2394455) /gene="yrdC" /locus_tag="BSU_26760" /old_locus_tag="BSU26760" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390553.1" /db_xref="EnsemblGenomes-Gn:BSU26760" /db_xref="EnsemblGenomes-Tr:CAB14617" /db_xref="GOA:O07081" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12283" /db_xref="UniProtKB/Swiss-Prot:O07081" /translation="MEEKKALIIVDVQKAFDDKKWGERNNVKAEENISKILELWREKG WTVIYIQHTSDKPHSLFHPKNEGFAIKEIVKPMDEEVIITKTVNSSFIGTNLEEFLKL NEITTVVITGLTTPHCVSTTTRMSGNLGFDTYLISDATAAFGMRDQNDTYYDAATIHN ISLATLHDEFATILTTDQLINDFIKTH*" /label="yrdC CDS" gene complement(2393892..2394455) /gene="yrdC" /locus_tag="BSU_26760" /old_locus_tag="BSU26760" /label="yrdC gene" downshifts 2394373 /Source="Nicolas_upshifts" /id="D1368" /incds=1 /nref=44 /ntot=194 /MaxReadThrough="1.72227" /MaxDrop="3.37915" /score="14.6499034" /energy="-6.6" /TU="NA" /idTUdmin="U2060" /TUdmin="-4488" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2394485..2394504) /Source="Nicolas_upshift_promotors" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2394493) /Source="Nicolas_upshifts" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2394519..2394526) /Source="Nicolas_upshift_promotors" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2394684..2395055) /gene="yrdB" /locus_tag="BSU_26770" /old_locus_tag="BSU26770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390554.1" /db_xref="EnsemblGenomes-Gn:BSU26770" /db_xref="EnsemblGenomes-Tr:CAB14618" /db_xref="GOA:O07080" /db_xref="InterPro:IPR021214" /db_xref="SubtiList:BG12282" /db_xref="UniProtKB/Swiss-Prot:O07080" /translation="MEKLNQTNLLLRFTLEIAALISLGVYAWISFNGYFKYVLTLVLP IAVMIVWSVFAVPHDPSRSGQTVIAVNGVTRLVIELLIFAMAVAALYFSYLKPVSIVF LCLIILHYIISAERIKWLLNQ*" /label="yrdB CDS" gene complement(2394684..2395055) /gene="yrdB" /locus_tag="BSU_26770" /old_locus_tag="BSU26770" /label="yrdB gene" S_feature complement(2395056..2395285) /Source="Nicolas_S_feature" /locus_tag="new_2734144_2734373_c" /HighExp="BMM, GM 120, GM 90, SMM, MG 150, GM 60, MG 120, M9-tran, Glu, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48162700000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1003" promotor_-10 complement(2395267..2395286) /Source="Nicolas_upshift_promotors" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="promotor_-10" upshifts complement(2395283) /Source="Nicolas_upshifts" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="upshifts" promotor_-35 complement(2395300..2395307) /Source="Nicolas_upshift_promotors" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="promotor_-35" downshifts complement(2395851) /Source="Nicolas_upshifts" /id="D1369" /incds=0 /nref=174 /ntot=248 /MaxReadThrough="2.42722" /MaxDrop="5.81863" /score="7.90390368" /energy="-10.3" /TU="NA" /idTUdmin="U2059" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2395865..2396368) /gene="yrdA" /locus_tag="BSU_26780" /old_locus_tag="BSU26780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390555.1" /db_xref="EnsemblGenomes-Gn:BSU26780" /db_xref="EnsemblGenomes-Tr:CAB14619" /db_xref="GOA:O07079" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12281" /db_xref="UniProtKB/Swiss-Prot:O07079" /translation="MFQTLDHFLKSWEFEADATQKLLNSLTDESLKQEITSQNWTLGR IAWHTVAAIGIITSNTDLTFQAPAEDYPVPTSAQFIADSYHQASNAFVQALKTQWTDH TLQERINFIGQQMPNGSLLMFLIQHQNHHRGQMTVLMRQAGLTVPGIYGPAKEEWAKF GLEAPKM*" /label="yrdA CDS" gene complement(2395865..2396368) /gene="yrdA" /locus_tag="BSU_26780" /old_locus_tag="BSU26780" /label="yrdA gene" S_feature complement(2396369..2396593) /Source="Nicolas_S_feature" /locus_tag="new_2735457_2735681_c" /HighExp="Etha, Lbstat, M0t90, M40t90, LoTm, M9-stat, Gly, S2, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1004" CDS complement(2396594..2397448) /gene="aadK" /locus_tag="BSU_26790" /old_locus_tag="BSU26790" /EC_number="2.7.7.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8293959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8293959; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aminoglycoside 6-adenylyltransferase" /protein_id="NP_390556.1" /db_xref="EnsemblGenomes-Gn:BSU26790" /db_xref="EnsemblGenomes-Tr:CAB14620" /db_xref="GOA:P17585" /db_xref="InterPro:IPR007530" /db_xref="PDB:2PBE" /db_xref="SubtiList:BG11037" /db_xref="UniProtKB/Swiss-Prot:P17585" /translation="MRSEQEMMDIFLDFALNDERIRLVTLEGSRTNRNIPPDNFQDYD ISYFVTDVESFKENDQWLEIFGKRIMMQKPEDMELFPPELGNWFSYIILFEDGNKLDL TLIPIREAEDYFANNDGLVKVLLDKDSFINYKVTPNDRQYWIKRPTAREFDDCCNEFW MVSTYVVKGLARNEILFAIDHLNEIVRPNLLRMMAWHIASQKGYSFSMGKNYKFMKRY LSNKEWEELMSTYSVNGYQEMWKSLFTCYALFRKYSKAVSEGLAYKYPDYDEGITKYT EGIYCSVK*" /label="aadK CDS" gene complement(2396594..2397448) /gene="aadK" /locus_tag="BSU_26790" /old_locus_tag="BSU26790" /label="aadK gene" S_feature complement(2397449..2397551) /Source="Nicolas_S_feature" /locus_tag="new_2736537_2736639_c" /HighExp="M9-stat, T3.0H, T0.30H, T1.30H, T2.30H, Lbtran, T3.30H, T1.0H, M0t90, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1005" promotor_-10 complement(2397532..2397551) /Source="Nicolas_upshift_promotors" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2397549) /Source="Nicolas_upshifts" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2397566..2397569) /Source="Nicolas_upshift_promotors" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2397720..2397727 /Source="Nicolas_upshift_promotors" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2397741..2397760 /Source="Nicolas_upshift_promotors" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2397756 /Source="Nicolas_upshifts" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="upshifts" S_feature 2397761..2397826 /Source="Nicolas_S_feature" /locus_tag="new_2736849_2736914" /HighExp="LoTm, BC, S1, S2, C90, T4.0H, HiOs, T5.0H, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.894" /TUlongSig="NA" /TUlongPSig="NA" /label="S1006" CDS 2397827..2398870 /gene="yrpB" /locus_tag="BSU_26800" /old_locus_tag="BSU26800" /EC_number="1.13.12.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9501443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative anionic nitroalkane monoxygenase" /protein_id="NP_390557.1" /db_xref="EnsemblGenomes-Gn:BSU26800" /db_xref="EnsemblGenomes-Tr:CAB14621" /db_xref="GOA:O05413" /db_xref="InterPro:IPR004136" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12305" /db_xref="UniProtKB/Swiss-Prot:O05413" /translation="MNEFMKKFSLTKPIIQAPMAGGITKPRLASAVSNQGALGSLASG YLTPDLLEQQIKEIFELTDAPFQINVFVPLGLEMPPKDQIKKWKENIPLANQVNQFTS VQEEWDDFYQKIDLILKYKVKACSFTFDLPPEDAVKELKTAGCCLIGTASTVEEALLM EERGMDIVVLQGSEAGGHRGAFLPSKGESAVGLMALIPQAADALSVPVIAAGGMIDHR GVKAALTLGAQGVQIGSAFLICHESNAHPVHKQKILEANEADTKLTTLFSGKEARGIV NKWMEENEQFETQTLPYPYQNTLTKAMRQKASLQNNHDQMSLWAGQGIRSLTEEISVK QLLNQLCQEDIKI*" /label="yrpB CDS" gene 2397827..2398870 /gene="yrpB" /locus_tag="BSU_26800" /old_locus_tag="BSU26800" /label="yrpB gene" downshifts 2398868 /Source="Nicolas_upshifts" /id="D1370" /incds=0 /nref=22 /ntot=198 /MaxReadThrough="1.3622" /MaxDrop="5.04821" /score="14.6499034" /energy="-6.6" /TU="NA" /idTUdmin="U2060" /TUdmin=7 /isTUend="TRUE" /label="downshifts" promotor_-35 2399155..2399162 /Source="Nicolas_upshift_promotors" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="promotor_-35" upshifts 2399169 /Source="Nicolas_upshifts" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="upshifts" promotor_-10 2399176..2399195 /Source="Nicolas_upshift_promotors" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="promotor_-10" CDS 2399220..2400017 /gene="murI" /locus_tag="BSU_26810" /old_locus_tag="BSU26810" /EC_number="5.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12829290, 15212785, 15347750, 17720142, 25777674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12829290, 15212785, 15347750, 17720142, 25777674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390558.1" /db_xref="EnsemblGenomes-Gn:BSU26810" /db_xref="EnsemblGenomes-Tr:CAB14622" /db_xref="GOA:O05412" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="SubtiList:BG12306" /db_xref="UniProtKB/Swiss-Prot:O05412" /translation="MKIGFFDSGIGGMTVLYEAIKVLPYEDYIFYADTLNVPYGEKSK GKVKEYIFNAAEFLASQNIKALVIACNTATSIAIEDLRRNFDFPIIGIEPAVKPAINK CTEERKRVLVVATNLTLKEEKFHNLVKEIDHHDLVDCLALPGLVEFAENFDFSEDKII KYLKNELSSFDLKQYGTIVLGCTHFPFFKNSFEKLFGIKVDMISGSVGTAKQLKKVLA DRNQLGKGSGSITFFNSGHKIVDQEVISKYKRLFEILDETQRSHVGH*" /label="murI CDS" gene 2399220..2400017 /gene="murI" /locus_tag="BSU_26810" /old_locus_tag="BSU26810" /label="murI gene" promotor_-35 2400323..2400327 /Source="Nicolas_upshift_promotors" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2400341..2400360 /Source="Nicolas_upshift_promotors" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2400351 /Source="Nicolas_upshifts" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2400375..2400389) /Source="Nicolas_upshift_promotors" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2400389) /Source="Nicolas_upshifts" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2400398..2400402) /Source="Nicolas_upshift_promotors" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2400398..2401105 /gene="yrpD" /locus_tag="BSU_26820" /old_locus_tag="BSU26820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390559.1" /db_xref="EnsemblGenomes-Gn:BSU26820" /db_xref="EnsemblGenomes-Tr:CAB14623" /db_xref="InterPro:IPR029143" /db_xref="SubtiList:BG12307" /db_xref="UniProtKB/Swiss-Prot:O05411" /translation="MMKKGLLAGALTATVLFGTCAVDVPGIISPKTAEAASQLTDGIG GRAYLNSNGAILVTKIQLPSSTQVSNGTAYIYSGFSGGTESDIGFQYSDKYNVWKPYM KVGSKGQDQVQYLEGGSQFTNTKGFRPGSTVQLTIYKNLNGNTRATYWGTNNAGYNGR LISEISKTNVGSISKWKALATVATTGSRQSIKSNFSTSFTNITIDNKAITPVIDTQDF AKVTVSGNSVSLSVVKN*" /label="yrpD CDS" gene 2400398..2401105 /gene="yrpD" /locus_tag="BSU_26820" /old_locus_tag="BSU26820" /label="yrpD gene" downshifts 2401105 /Source="Nicolas_upshifts" /id="D1371" /incds=0 /nref=4 /ntot=168 /MaxReadThrough="5.98921" /MaxDrop="2.677" /score="15.7112026" /energy="-8.2" /TU="U2062" /idTUdmin="U2064" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" S_feature 2401150..2401323 /Source="Nicolas_S_feature" /locus_tag="new_2740238_2740411" /HighExp="Lbstat, M0t90, M40t90, BT, S0, ferm, S2, M9-stat, Lbtran, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="SigA" /TUlongPSig=1 /label="S1007" promotor_-35 2401305..2401306 /Source="Nicolas_upshift_promotors" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2401322..2401341 /Source="Nicolas_upshift_promotors" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2401325..2401653 /Source="Nicolas_S_feature" /locus_tag="new_2740413_2740741" /HighExp="Lbstat, M0t90, BT, M40t90, S2, S0, ferm, T2.0H, M9-stat, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99711000000000005" /TUshortSig="SigA, SigA" /TUshortPSig="0.861, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1008" upshifts 2401325 /Source="Nicolas_upshifts" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="upshifts" CDS 2401429..2401590 /locus_tag="BSU_26829" /old_locus_tag="BSU26829" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90581.1" /translation="MYFHKRGMASYSSIASGRLANDWPRTTHHFETDSFQNHKYDPIT NKDQLAVQP*" /label="hypothetical protein CDS" gene 2401429..2401590 /locus_tag="BSU_26829" /old_locus_tag="BSU26829" /pseudo /label="gene" promotor_-35 2401619..2401628 /Source="Nicolas_upshift_promotors" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2401641..2401660 /Source="Nicolas_upshift_promotors" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2401655..2401806 /Source="Nicolas_S_feature" /locus_tag="new_2740743_2740894" /HighExp="BT, S8, B36, S7, Lbstat, G/S, Pyr, M0t90, B60, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94474599999999997" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.861, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1009" upshifts 2401655 /Source="Nicolas_upshifts" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="upshifts" CDS 2401681..2401758 /gene="yrpDX" /locus_tag="BSU_26826" /old_locus_tag="BSU26826" /experiment="publication(s) with functional evidences, PMID:20709900" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="expressed polypeptide of unknown function" /protein_id="YP_009513985.1" /db_xref="EnsemblGenomes-Gn:BSU26826" /db_xref="EnsemblGenomes-Tr:CCQ48602" /db_xref="GOA:L8E9J8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8E9J8" /translation="MRSFPLIVVLFILLIIVGTSFFGGY*" /label="yrpDX CDS" gene 2401681..2401758 /gene="yrpDX" /locus_tag="BSU_26826" /old_locus_tag="BSU26826" /label="yrpDX gene" downshifts 2401763 /Source="Nicolas_upshifts" /id="D1372" /incds=0 /nref=23 /ntot=198 /MaxReadThrough="3.86249" /MaxDrop="4.0885" /score="28.4802594" /energy="-18.1" /TU="U2062,U2065" /idTUdmin="U2064" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature 2401808..2402005 /Source="Nicolas_S_feature" /locus_tag="new_2740896_2741093" /HighExp="BT, B36, S8, Lbstat, G/S, Pyr, Diami, S7, dia15, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1010" S_feature complement(2401997..2402268) /Source="Nicolas_S_feature" /locus_tag="new_2741085_2741356_c" /HighExp="Heat, BMM, Etha, S2, S3, S4, B36, S5, B60, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40965600000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1011" downshifts complement(2402039) /Source="Nicolas_upshifts" /id="D1373" /incds=0 /nref=37 /ntot=78 /MaxReadThrough="2.30607" /MaxDrop="6.9537" /score="19.9821634" /energy="-15.5" /TU="NA" /idTUdmin="U2066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2402045..2402206) /locus_tag="BSU_26827" /old_locus_tag="BSU26827" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513986.1" /translation="MGKKLIETIQYPPYYCDVAYLESSHMKSRRNLFQNKKSLDVWQW ITLEIYWLI*" /label="hypothetical protein CDS" gene complement(2402045..2402206) /locus_tag="BSU_26827" /old_locus_tag="BSU26827" /label="gene" CDS complement(2402269..2403024) /gene="zinT" /locus_tag="BSU_26830" /old_locus_tag="BSU26830" /function="16.14: Store" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 24128931; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein buffering protein for Zn2+ transport" /protein_id="NP_390560.1" /db_xref="EnsemblGenomes-Gn:BSU26830" /db_xref="EnsemblGenomes-Tr:CAB14624" /db_xref="GOA:O05410" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015304" /db_xref="SubtiList:BG12308" /db_xref="UniProtKB/Swiss-Prot:O05410" /translation="MNILFSKRLGILTIGSLLVLAGCQTSGSSAGESNQTTSSSAVEE DSSKTQEQTSDSHTHEHSHDHSHAHDEETEKIYEGYFKNSQVKDRLLSDWEGDWQSVY PYLQDGTLDEVFSYKSEHEGGKTAEEYKEYYKKGYQTDVDRIVIQKDTVTFFKNGKEY SGKYTYDGYEILTYDAGNRGVRYIFKLAKKAEGLPQYIQFSDHSIYPTKASHYHLYWG DDREALLDEVKNWPTYYPSKMDGHDIAHEMMAH*" /label="zinT CDS" gene complement(2402269..2403024) /gene="zinT" /locus_tag="BSU_26830" /old_locus_tag="BSU26830" /label="zinT gene" promotor_-10 complement(2403055..2403074) /Source="Nicolas_upshift_promotors" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2403071) /Source="Nicolas_upshifts" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2403090..2403095) /Source="Nicolas_upshift_promotors" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2403156..2403686) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" /label="sigZ CDS" gene complement(2403156..2403686) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /label="sigZ gene" promotor_-10 complement(2403732..2403751) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2403755) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2403765..2403772) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2403821..2404801 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" /label="yrpG CDS" gene 2403821..2404801 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /label="yrpG gene" CDS complement(2405075..2406391) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" /label="yraO CDS" gene complement(2405075..2406391) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /label="yraO gene" S_feature complement(2406392..2406505) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2406506..2407375) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" /label="yraN CDS" gene complement(2406506..2407375) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /label="yraN gene" promotor_-10 complement(2407398..2407417) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2407415) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2407432..2407437) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2407482..2407483) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2407490) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2407520..2407521) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2407520..2408623 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" /label="prpF CDS" gene 2407520..2408623 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /label="prpF gene" misc_feature 2408513..2408532 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2408519 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2408870) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" /label="downshifts" CDS complement(2408896..2409729) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" /label="csn CDS" gene complement(2408896..2409729) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /label="csn gene" misc_feature complement(2409759..2409778) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2409768) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2409934..2409938 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2409949..2410171 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2409949 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2409953..2409972 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2410172..2410435 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" /label="yraL CDS" gene 2410172..2410435 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /label="yraL gene" downshifts 2410423 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS 2410572..2411387 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" /label="yraK CDS" gene 2410572..2411387 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /label="yraK gene" S_feature complement(2411722..2411794) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2411765) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2411795..2412151) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" /label="yraJ CDS" gene complement(2411795..2412151) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /label="yraJ gene" CDS complement(2412204..2412563) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" /label="yraI CDS" gene complement(2412204..2412563) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /label="yraI gene" misc_feature complement(2412656..2412675) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2412666) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2412835..2412936) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" /label="hypothetical protein CDS" gene complement(2412835..2412936) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /label="gene" S_feature complement(2412976..2413078) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2413018) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2413079..2413465) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" /label="yraH CDS" gene complement(2413079..2413465) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /label="yraH gene" misc_feature complement(2413507..2413523) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2413523) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2413656..2413662 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2413677..2413688 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2413677 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="upshifts" CDS 2413714..2413959 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" /label="yraG CDS" gene 2413714..2413959 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /label="yraG gene" CDS 2413977..2414345 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" /label="yraF CDS" gene 2413977..2414345 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /label="yraF gene" CDS 2414364..2415500 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" /label="adhB CDS" gene 2414364..2415500 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /label="adhB gene" CDS 2415519..2415716 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" /label="yraE CDS" gene 2415519..2415716 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /label="yraE gene" CDS 2415732..2416031 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" /label="yraD CDS" gene 2415732..2416031 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /label="yraD gene" downshifts 2416022 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2416294..2416716) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" /label="adhR CDS" gene complement(2416294..2416716) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /label="adhR gene" promotor_-35 2416714..2416717 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2416733..2416752 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2416748..2416898 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2416748 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="upshifts" promotor_-10 complement(2416751..2416770) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2416758) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2416784..2416791) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2416867..2416886) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2416875) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="upshifts" CDS 2416899..2417093 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" /label="yrzP CDS" gene 2416899..2417093 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /label="yrzP gene" promotor_-35 complement(2416901..2416908) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2417111..2417118 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2417134..2417153 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2417138 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="upshifts" S_feature 2417139..2417223 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2417224..2418273 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" /label="adhA CDS" gene 2417224..2418273 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /label="adhA gene" promotor_-35 2418341..2418348 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2418363..2418382 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2418376 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="upshifts" CDS 2418404..2418913 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" /label="sufL CDS" gene 2418404..2418913 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /label="sufL gene" downshifts 2418882 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" /label="downshifts" S_feature 2418927..2420032 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2418955..2420988) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" /label="sacC CDS" gene complement(2418955..2420988) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /label="sacC gene" downshifts complement(2418980) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2420897..2421064) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" /label="hypothetical protein CDS" gene complement(2420897..2421064) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /label="gene" S_feature complement(2420989..2421144) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2421145..2421972) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " /label="levG CDS" gene complement(2421145..2421972) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /label="levG gene" CDS complement(2421993..2422802) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" /label="levF CDS" gene complement(2421993..2422802) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /label="levF gene" CDS complement(2422819..2423307) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" /label="levE CDS" gene complement(2422819..2423307) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /label="levE gene" CDS complement(2423307..2423747) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" /label="levD CDS" gene complement(2423307..2423747) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /label="levD gene" downshifts 2423744 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" /label="downshifts" misc_feature complement(2423784..2423802) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2423788) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2423937..2426744) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" /label="levR CDS" gene complement(2423937..2426744) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /label="levR gene" misc_feature complement(2426960..2426979) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2426966) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="upshifts" CDS 2427291..2427431 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" /label="hypothetical protein CDS" gene 2427291..2427431 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /label="gene" misc_feature 2427412..2427431 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2427422 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="upshifts" CDS 2427470..2428858 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" /label="aapA CDS" gene 2427470..2428858 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /label="aapA gene" downshifts 2428847 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(2428880..2428953) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2428922) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2428954..2429586) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" /label="yrhP CDS" gene complement(2428954..2429586) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /label="yrhP gene" downshifts complement(2429010) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2429640..2429659) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2429651) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2429665..2429671 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2429674..2429681) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2429685..2429704 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2429690 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="upshifts" CDS 2429739..2430566 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " /label="yrhO CDS" gene 2429739..2430566 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /label="yrhO gene" downshifts 2430562 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2430679..2430688 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2430701..2430716 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2430706 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="upshifts" CDS 2430762..2431262 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" /label="sigV CDS" gene 2430762..2431262 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /label="sigV gene" CDS 2431262..2432119 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" /label="rsiV CDS" gene 2431262..2432119 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /label="rsiV gene" promotor_-10 complement(2432137..2432148) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2432156) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2432163..2432169) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2432230..2434134 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" /label="oatA CDS" gene 2432230..2434134 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /label="oatA gene" promotor_-35 2434215..2434221 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2434237..2434255 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2434243 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="upshifts" CDS 2434268..2434558 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" /label="yrhK CDS" gene 2434268..2434558 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /label="yrhK gene" S_feature 2434559..2434674 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2434656..2434663 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2434676..2434801 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2434676 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2434677..2434695 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2434695..2434795 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" /label="surF RNA" gene 2434695..2434795 /gene="surF" /locus_tag="BSU_misc_RNA_82" /label="surF gene" downshifts 2434758 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2434802..2437966) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" /label="cypB CDS" gene complement(2434802..2437966) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /label="cypB gene" downshifts complement(2434818) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2435952..2435961 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2435975..2435994 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2435996 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2437982..2438566) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" /label="bscR CDS" gene complement(2437982..2438566) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /label="bscR gene" CDS complement(2438789..2439331) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" /label="yrhH CDS" gene complement(2438789..2439331) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /label="yrhH gene" S_feature complement(2439332..2439417) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2439415..2439430) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2439417) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2439443..2439452) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2439486..2439702) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2439520..2439678) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" /label="hypothetical protein CDS" gene complement(2439520..2439678) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /label="gene" downshifts complement(2439529) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2439700..2439719) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2439702) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2439704..2439834) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2439733..2439742) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2439835..2439984) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" /label="yrzI CDS" gene complement(2439835..2439984) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /label="yrzI gene" downshifts 2439978 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" /label="downshifts" S_feature complement(2439985..2440075) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2440077..2440296) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2440120) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" downshifts 2440242 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2440275..2440294) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2440296) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2440298..2440373) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2440309..2440316) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2440374..2441174) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" /label="yrhG CDS" gene complement(2440374..2441174) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /label="yrhG gene" S_feature complement(2441243..2441396) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2441286) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2441387..2441406) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2441396) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="upshifts" promotor_-35 complement(2441421..2441427) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2441437..2441805) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" /label="yrhF CDS" gene complement(2441437..2441805) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /label="yrhF gene" S_feature complement(2441806..2441902) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2441888..2441907) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2441892..2441895 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2441908) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="upshifts" promotor_-10 2441911..2441930 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2441913 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="upshifts" S_feature 2441914..2442120 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2441923..2441927) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2442121..2445063 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" /label="yrhE CDS" gene 2442121..2445063 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /label="yrhE gene" CDS 2445082..2445564 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" /label="yrhD CDS" gene 2445082..2445564 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /label="yrhD gene" downshifts 2445544 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2445600..2445830) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" /label="yrhC CDS" gene complement(2445600..2445830) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /label="yrhC gene" downshifts complement(2445620) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2445831..2445912) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2445913..2447052) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" /label="mccB CDS" gene complement(2445913..2447052) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /label="mccB gene" CDS complement(2447054..2447977) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" /label="mccA CDS" gene complement(2447054..2447977) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /label="mccA gene" downshifts complement(2447970) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" /label="downshifts" S_feature complement(2447978..2448041) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2448042..2448737) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" /label="mtnN CDS" gene complement(2448042..2448737) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /label="mtnN gene" promotor_-10 complement(2448477..2448496) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2448495) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2448509..2448518) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2448758..2449399) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" /label="yrrT CDS" gene complement(2448758..2449399) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /label="yrrT gene" promotor_-10 complement(2448966..2448985) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2448985) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2449002..2449005) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2449451..2449460 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2449457..2449476) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2449463) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2449473..2449492 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2449482..2449546 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2449482 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2449492..2449495) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2449527..2449534 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2449548 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2449550..2449567 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2449592..2449795 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" /label="yrzA CDS" gene 2449592..2449795 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /label="yrzA gene" downshifts 2449802 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2449832..2450533) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" /label="yrrS CDS" gene complement(2449832..2450533) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /label="yrrS gene" downshifts complement(2449844) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2450598..2452352) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" /label="pbpI CDS" gene complement(2450598..2452352) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /label="pbpI gene" misc_feature complement(2450626..2450645) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2450636) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2451667..2451682) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2451670) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2451695..2451704) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2451898..2451916) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2451912) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2451931..2451938 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2451931..2451936) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2451953..2451972 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2451958 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2452406..2452879) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" /label="greA CDS" gene complement(2452406..2452879) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /label="greA gene" downshifts complement(2452413) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(2452880..2453012) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2452994..2453013) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2453012) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2453014..2453122) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2453027..2453034) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2453115..2453134) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2453122) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2453130..2453765) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" /label="udk CDS" gene complement(2453130..2453765) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /label="udk gene" promotor_-35 complement(2453150..2453154) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2453260..2453265 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2453281..2453299 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2453288 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2453772..2455040) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" /label="yrrO CDS" gene complement(2453772..2455040) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /label="yrrO gene" CDS complement(2455059..2455988) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" /label="yrrN CDS" gene complement(2455059..2455988) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /label="yrrN gene" CDS complement(2455994..2456647) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " /label="yrrM CDS" gene complement(2455994..2456647) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /label="yrrM gene" S_feature complement(2456648..2456752) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2456734..2456753) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2456752) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2456769..2456773) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2456799..2457881) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" /label="yrrL CDS" gene complement(2456799..2457881) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /label="yrrL gene" downshifts complement(2456833) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2457897..2457916) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2457917) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2457931..2457934) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2458007) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2458012..2458293) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" /label="yrzB CDS" gene complement(2458012..2458293) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /label="yrzB gene" downshifts complement(2458072) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2458311..2458727) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" /label="rimF CDS" gene complement(2458311..2458727) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /label="rimF gene" promotor_-10 complement(2458559..2458577) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2458578) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2458593..2458598) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2458735..2459001) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" /label="yrzL CDS" gene complement(2458735..2459001) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /label="yrzL gene" promotor_-35 2458889..2458897 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2458912..2458931 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2458920..2460109 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2458920 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2459002..2459062) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2459056..2459075) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2459062) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2459086..2461722) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" /label="alaS CDS" gene complement(2459086..2461722) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /label="alaS gene" promotor_-35 complement(2459089..2459096) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2461488..2461506) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2461504) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2461520..2461527) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2461723..2461801) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2461802..2462009) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboA RNA" gene complement(2461802..2462009) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /label="tboA gene" promotor_-10 complement(2462017..2462036) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2462032) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2462051..2462058) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2462053..2463114) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" /label="yrrI CDS" gene complement(2462053..2463114) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /label="yrrI gene" promotor_-35 2463023..2463028 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2463034..2463269 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2463035 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2463044..2463062 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2463131..2463142) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2463132) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2463156..2463162) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2463270..2463998 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" /label="glnQ CDS" gene 2463270..2463998 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /label="glnQ gene" downshifts complement(2463726) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" CDS 2464020..2464841 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" /label="glnH CDS" gene 2464020..2464841 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /label="glnH gene" CDS 2464902..2465552 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" /label="glnM CDS" gene 2464902..2465552 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /label="glnM gene" CDS 2465569..2466225 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" /label="glnP CDS" gene 2465569..2466225 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /label="glnP gene" downshifts 2466224 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2466260..2466391) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " /label="yrzQ CDS" gene complement(2466260..2466391) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /label="yrzQ gene" downshifts complement(2466278) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2466413..2466604) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" /label="yrzR CDS" gene complement(2466413..2466604) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /label="yrzR gene" CDS complement(2466616..2467140) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" /label="yrrD CDS" gene complement(2466616..2467140) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /label="yrrD gene" upshifts complement(2466727) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2466731..2466742) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2466757..2466763) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2467111..2467122) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2467117) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2467137..2467143) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2467198..2469594) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" /label="recDB CDS" gene complement(2467198..2469594) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /label="recDB gene" downshifts complement(2467224) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2467444..2467450 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2467458 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2467465..2467476 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2467478..2467827 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2467579) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" /label="downshifts" CDS complement(2469619..2470239) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" /label="yrrB CDS" gene complement(2469619..2470239) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /label="yrrB gene" CDS complement(2470325..2471440) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" /label="mnmA CDS" gene complement(2470325..2471440) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /label="mnmA gene" downshifts complement(2470326) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" CDS complement(2471471..2472610) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" /label="iscSA CDS" gene complement(2471471..2472610) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /label="iscSA gene" promotor_-10 complement(2472177..2472196) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2472189) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2472210..2472217) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2472629..2473045) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" /label="cymR CDS" gene complement(2472629..2473045) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /label="cymR gene" S_feature complement(2473046..2473143) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2473128..2473147) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2473143) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2473163..2473166) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2473191..2473198 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2473212..2473231 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2473220 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="upshifts" CDS 2473248..2474513 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" /label="rarA CDS" gene 2473248..2474513 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /label="rarA gene" downshifts 2474512 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2474555..2475319) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" /label="tcdA CDS" gene complement(2474555..2475319) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /label="tcdA gene" downshifts complement(2474573) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2475403..2475603) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" /label="ssrSB RNA" gene complement(2475403..2475603) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /label="ssrSB gene" downshifts complement(2475421) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" /label="downshifts" upshifts 2475590 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2475591..2475600 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2475601..2475620) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2475612) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2475633..2475640) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2475655..2477433) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" /label="aspS CDS" gene complement(2475655..2477433) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /label="aspS gene" CDS complement(2477447..2478721) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" /label="hisS CDS" gene complement(2477447..2478721) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /label="hisS gene" misc_RNA complement(2478811..2479043) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" /label="tboH RNA" gene complement(2478811..2479043) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /label="tboH gene" downshifts complement(2478841) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2479053..2479056 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2479067..2479086) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2479071..2479090 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2479073..2479357 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2479073 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2479086) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2479101..2479108) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2479103..2479273) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" /label="yrzK CDS" gene complement(2479103..2479273) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /label="yrzK gene" promotor_-10 complement(2479304..2479315) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2479321) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="upshifts" promotor_-35 complement(2479330..2479336) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2479333..2479340 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2479354..2479372 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2479359 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2479406..2480962 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" /label="yrvJ CDS" gene 2479406..2480962 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /label="yrvJ gene" downshifts 2480941 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2480989..2481387) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" /label="dtd CDS" gene complement(2480989..2481387) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /label="dtd gene" downshifts complement(2480997) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2481441..2483645) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" /label="rsh CDS" gene complement(2481441..2483645) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /label="rsh gene" promotor_-10 complement(2483674..2483693) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2483681) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2483683..2483773) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2483708..2483715) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2483737 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" /label="downshifts" CDS complement(2483813..2484325) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" /label="apt CDS" gene complement(2483813..2484325) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /label="apt gene" downshifts complement(2483818) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" CDS complement(2484331..2486691) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" /label="recJ CDS" gene complement(2484331..2486691) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /label="recJ gene" promotor_-10 complement(2484795..2484814) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2484803) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2484828..2484837) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2486705..2486724) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2486716) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2486739..2486745) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2486758..2487081) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" /label="yrvD CDS" gene complement(2486758..2487081) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /label="yrvD gene" promotor_-10 complement(2487102..2487120) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2487113) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2487135..2487141) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2487157..2487654) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" /label="yrvC CDS" gene complement(2487157..2487654) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /label="yrvC gene" S_feature complement(2487655..2487730) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2487724..2487743) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2487730) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="upshifts" promotor_-35 complement(2487757..2487764) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2487812..2490025) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" /label="secDF CDS" gene complement(2487812..2490025) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /label="secDF gene" downshifts complement(2487817) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" promotor_-35 2489584..2489589 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2489603..2489622 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2489611 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2490064..2490360) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" /label="comN CDS" gene complement(2490064..2490360) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /label="comN gene" downshifts 2490271 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" /label="downshifts" S_feature complement(2490361..2490439) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2490401..2490406 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2490423..2490441 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2490425..2490444) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2490425 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="upshifts" upshifts complement(2490439) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="upshifts" S_feature complement(2490441..2491359) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2490459..2490462) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2490476..2492032 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" /label="spoVB CDS" gene 2490476..2492032 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /label="spoVB gene" promotor_-10 complement(2491345..2491363) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2491359) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="upshifts" promotor_-35 complement(2491375..2491383) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2492033..2492797 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2492036..2492692) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" /label="yrbG CDS" gene complement(2492036..2492692) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /label="yrbG gene" promotor_-10 complement(2492711..2492722) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2492723) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2492736..2492742) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2492775..2492780 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2492796..2492814 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2492799 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2492827..2493279 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" /label="yrzE CDS" gene 2492827..2493279 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /label="yrzE gene" downshifts 2493263 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2493318) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2493336..2493602) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" /label="yrbF CDS" gene complement(2493336..2493602) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /label="yrbF gene" CDS complement(2493639..2494784) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" /label="tgt CDS" gene complement(2493639..2494784) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /label="tgt gene" upshifts complement(2493691) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2493735) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2493737..2493756) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2493771..2493776) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2494811..2495839) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" /label="queA CDS" gene complement(2494811..2495839) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /label="queA gene" CDS complement(2495869..2496069) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" /label="yrzS CDS" gene complement(2495869..2496069) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /label="yrzS gene" CDS complement(2496062..2497066) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" /label="ruvB CDS" gene complement(2496062..2497066) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /label="ruvB gene" CDS complement(2497077..2497682) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" /label="ruvA CDS" gene complement(2497077..2497682) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /label="ruvA gene" promotor_-10 complement(2497701..2497720) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2497717) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2497719..2497820) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2497731..2497737) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2497821..2498333) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" /label="bofC CDS" gene complement(2497821..2498333) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /label="bofC gene" promotor_-10 complement(2498362..2498373) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2498377) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="upshifts" CDS complement(2498381..2499688) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" /label="csbX CDS" gene complement(2498381..2499688) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /label="csbX gene" promotor_-35 complement(2498388..2498394) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2499642) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2499712..2499730) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2499727) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="upshifts" promotor_-35 complement(2499745..2499751) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2499759..2500784) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" /label="yrbE CDS" gene complement(2499759..2500784) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /label="yrbE gene" promotor_-10 complement(2500821..2500840) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2500841) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="upshifts" promotor_-35 complement(2500855..2500862) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2500910..2500917 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2500931..2500950 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2500939 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2500971..2500976 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2500985 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2500992..2501010 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2501022..2501669 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" /label="yrzF CDS" gene 2501022..2501669 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /label="yrzF gene" S_feature complement(2501344..2501677) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2501648 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(2501679..2501876) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2501715..2501837) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" /label="hypothetical protein CDS" gene complement(2501715..2501837) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /label="gene" downshifts complement(2501722) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2501885) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2501886..2501903) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2501910..2501917) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2501922..2502212 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" /label="yrzH CDS" gene 2501922..2502212 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /label="yrzH gene" misc_feature 2501933..2501952 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2501933..2502080 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2501933 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="upshifts" CDS 2502219..2502359 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" /label="yrzT CDS" gene 2502219..2502359 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /label="yrzT gene" downshifts 2502348 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2502408..2502414 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2502422..2502522 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2502429..2502447 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2502430 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="upshifts" upshifts 2502482 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="upshifts" CDS 2502523..2503977 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" /label="alaP CDS" gene 2502523..2503977 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /label="alaP gene" downshifts 2503978 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2504018..2504740) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" /label="yrbC CDS" gene complement(2504018..2504740) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /label="yrbC gene" S_feature 2504023..2504444 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2504034) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2504763..2504782) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2504780) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2504796..2504803) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2504843..2505439) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" /label="sgpA CDS" gene complement(2504843..2505439) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /label="sgpA gene" downshifts complement(2504858) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2505482..2505493) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2505484) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2505486..2505550) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2505508..2505514) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2505587..2506750) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" /label="safA CDS" gene complement(2505587..2506750) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /label="safA gene" downshifts complement(2505595) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" /label="downshifts" S_feature complement(2506751..2506826) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2506802..2506820) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2506826) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2506836..2506841) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2506867..2507973) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" /label="nadA CDS" gene complement(2506867..2507973) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /label="nadA gene" promotor_-10 complement(2507549..2507567) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2507574) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2507583..2507588) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2507885 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2507886..2507889 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2507960..2508829) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" /label="nadC CDS" gene complement(2507960..2508829) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /label="nadC gene" downshifts 2508054 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2508783..2510378) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" /label="nadB CDS" gene complement(2508783..2510378) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /label="nadB gene" promotor_-35 2510406..2510413 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2510406..2510425) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2510427 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2510429..2510448 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2510430) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2510440..2510447) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2510481..2511668 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" /label="nifS CDS" gene 2510481..2511668 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /label="nifS gene" promotor_-10 complement(2510482..2510501) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2510500) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2510516..2510525) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2511383..2511388 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2511397 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2511399..2511418 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2511628..2512170 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" /label="niaR CDS" gene 2511628..2512170 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /label="niaR gene" downshifts 2512153 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2512195..2513052) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" /label="pheA CDS" gene complement(2512195..2513052) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /label="pheA gene" S_feature 2512198..2512907 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2512215) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2513069..2513512) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" /label="thrR CDS" gene complement(2513069..2513512) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /label="thrR gene" CDS complement(2513573..2514859) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" /label="obgE CDS" gene complement(2513573..2514859) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /label="obgE gene" CDS complement(2514893..2515471) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" /label="spo0B CDS" gene complement(2514893..2515471) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /label="spo0B gene" S_feature complement(2515472..2515537) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2515522..2515541) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2515537) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2515539..2515756) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2515549..2515671 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" /label="hypothetical protein CDS" gene 2515549..2515671 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /label="gene" promotor_-35 complement(2515555..2515562) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2515792..2516076) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" /label="rpmA CDS" gene complement(2515792..2516076) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /label="rpmA gene" downshifts complement(2515801) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" CDS complement(2516089..2516427) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" /label="rppA CDS" gene complement(2516089..2516427) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /label="rppA gene" CDS complement(2516430..2516738) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" /label="rplU CDS" gene complement(2516430..2516738) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /label="rplU gene" misc_RNA complement(2516752..2516827) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" /label="ldlU RNA" gene complement(2516752..2516827) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /label="ldlU gene" promotor_-10 complement(2516839..2516858) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2516859) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2516872..2516879) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2516885..2517751) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" /label="spoIVFB CDS" gene complement(2516885..2517751) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /label="spoIVFB gene" CDS complement(2517744..2518538) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" /label="spoIVFA CDS" gene complement(2517744..2518538) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /label="spoIVFA gene" downshifts 2518541 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" /label="downshifts" promotor_no_box 2518547..2518647 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2518562..2518580) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2518573) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="upshifts" promotor_-35 complement(2518596..2518601) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2518607 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2518650 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(2518685) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2518688..2519494) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" /label="minD CDS" gene complement(2518688..2519494) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /label="minD gene" CDS complement(2519496..2520176) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" /label="minC CDS" gene complement(2519496..2520176) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /label="minC gene" CDS complement(2520229..2520747) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" /label="mreD CDS" gene complement(2520229..2520747) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /label="mreD gene" CDS complement(2520744..2521616) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" /label="mreC CDS" gene complement(2520744..2521616) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /label="mreC gene" CDS complement(2521647..2522660) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" /label="mreB CDS" gene complement(2521647..2522660) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /label="mreB gene" upshifts complement(2522701) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2522713..2522731) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2522752..2523447) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" /label="ysxA CDS" gene complement(2522752..2523447) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /label="ysxA gene" CDS complement(2523484..2524053) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" /label="maf CDS" gene complement(2523484..2524053) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /label="maf gene" promotor_-10 complement(2523905..2523920) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2523914) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2523933..2523942) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2524092..2524111) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2524108) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2524125..2524131) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2524204) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2524206..2525204) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" /label="spoIIB CDS" gene complement(2524206..2525204) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /label="spoIIB gene" promotor_-10 complement(2525251..2525270) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2525259) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2525282..2525289) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2525327) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS complement(2525338..2526084) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" /label="comC CDS" gene complement(2525338..2526084) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /label="comC gene" promotor_-10 complement(2526112..2526131) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2526119) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2526146..2526153) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2526224..2527516) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" /label="folC CDS" gene complement(2526224..2527516) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /label="folC gene" downshifts complement(2526229) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2527517..2527575) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2527576..2530218) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" /label="valS CDS" gene complement(2527576..2530218) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /label="valS gene" S_feature complement(2530219..2530277) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2530278..2530500) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboV RNA" gene complement(2530278..2530500) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /label="tboV gene" downshifts complement(2530321) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2530529..2530548) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2530541) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2530543..2530651) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2530563..2530568) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2530605..2530614 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2530627..2530646 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2530628 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2530644..2530658) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2530651) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2530666..2530670) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2530666..2530857 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" /label="yszA CDS" gene 2530666..2530857 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /label="yszA gene" CDS complement(2530876..2531901) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" /label="cotN CDS" gene complement(2530876..2531901) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /label="cotN gene" downshifts complement(2530906) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" /label="downshifts" CDS complement(2531934..2533661) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" /label="spoVID CDS" gene complement(2531934..2533661) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /label="spoVID gene" promotor_-35 2533263..2533266 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2533282..2533301 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2533288 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2533657..2533661 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2533670..2533684 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2533684 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2533699..2533717) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2533715) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="upshifts" promotor_-35 complement(2533733..2533738) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2533792..2535084) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" /label="hemL CDS" gene complement(2533792..2535084) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /label="hemL gene" downshifts complement(2533809) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2535114..2536088) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" /label="hemB CDS" gene complement(2535114..2536088) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /label="hemB gene" CDS complement(2536085..2536873) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" /label="hemD CDS" gene complement(2536085..2536873) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /label="hemD gene" CDS complement(2536863..2537807) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" /label="hemC CDS" gene complement(2536863..2537807) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /label="hemC gene" CDS complement(2537840..2538670) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" /label="hemX CDS" gene complement(2537840..2538670) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /label="hemX gene" CDS complement(2538678..2540045) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" /label="hemA CDS" gene complement(2538678..2540045) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /label="hemA gene" misc_feature complement(2540109..2540128) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2540115) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2540117..2540206) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2540166..2540185 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2540174 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2540203..2540222) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2540206) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2540208..2540624) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2540233..2540241) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2540275..2540772 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" /label="ysxD CDS" gene 2540275..2540772 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /label="ysxD gene" promotor_-10 complement(2540608..2540626) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2540624) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2540626..2540756) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2540642..2540648) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2540736..2540747) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2540756) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="upshifts" promotor_-35 complement(2540762..2540768) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2540794..2541381) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" /label="engB CDS" gene complement(2540794..2541381) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /label="engB gene" downshifts complement(2540822) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2541378..2543702) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" /label="lonA CDS" gene complement(2541378..2543702) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /label="lonA gene" S_feature complement(2543703..2543814) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2543799..2543818) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2543814) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2543832..2543839) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2543883..2545541) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" /label="lonB CDS" gene complement(2543883..2545541) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /label="lonB gene" downshifts complement(2543902) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2545585..2545603) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2545596) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2545619..2545624) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2545693..2546955) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" /label="clpX CDS" gene complement(2545693..2546955) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /label="clpX gene" downshifts complement(2545703) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2546956..2547045) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2547033..2547052) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2547045) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2547047..2547178) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2547064..2547071) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2547223) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" CDS complement(2547227..2548501) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" /label="tig CDS" gene complement(2547227..2548501) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /label="tig gene" S_feature complement(2548502..2548691) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2548678..2548697) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2548691) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2548712..2548716) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2548729..2549733) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" /label="ysoA CDS" gene complement(2548729..2549733) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /label="ysoA gene" promotor_-10 complement(2549758..2549777) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2549776) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2549789..2549796) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2549852..2550451) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" /label="leuD CDS" gene complement(2549852..2550451) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /label="leuD gene" downshifts complement(2549873) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" /label="downshifts" CDS complement(2550464..2551882) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" /label="leuC CDS" gene complement(2550464..2551882) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /label="leuC gene" promotor_-35 2551771..2551775 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2551790..2551794 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2551790 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2551932..2553029) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" /label="leuB CDS" gene complement(2551932..2553029) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /label="leuB gene" CDS complement(2553050..2554606) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" /label="leuA CDS" gene complement(2553050..2554606) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /label="leuA gene" promotor_-35 2553446..2553449 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2553462..2555903 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2553462 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2553464..2553483 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2554593..2555621) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" /label="ilvC CDS" gene complement(2554593..2555621) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /label="ilvC gene" CDS complement(2555645..2556163) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" /label="ilvH CDS" gene complement(2555645..2556163) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /label="ilvH gene" promotor_-35 2555884..2555887 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2555903..2555907 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2555905 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2556160..2557884) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" /label="ilvB CDS" gene complement(2556160..2557884) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /label="ilvB gene" S_feature complement(2557885..2558005) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2558006..2558252) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboILV RNA" gene complement(2558006..2558252) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /label="tboILV gene" downshifts complement(2558049) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" /label="downshifts" S_feature complement(2558253..2558379) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2558361..2558380) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2558379) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="upshifts" S_feature complement(2558381..2558511) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2558395..2558402) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2558506..2558525) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2558515) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2558539..2558542) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2558637..2558646 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2558660..2558679 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2558662 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="upshifts" CDS 2558700..2559035 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" /label="cotQ CDS" gene 2558700..2559035 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /label="cotQ gene" downshifts 2559029 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-35 2559116..2559123 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2559137..2559156 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2559139..2559203 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2559139 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="upshifts" CDS 2559204..2559659 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" /label="ysnE CDS" gene 2559204..2559659 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /label="ysnE gene" promotor_-35 2559767..2559773 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2559787..2559805 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2559794 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="upshifts" CDS 2559843..2560664 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" /label="ysnF CDS" gene 2559843..2560664 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /label="ysnF gene" downshifts 2560657 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts 2560721 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" /label="downshifts" tRNA complement(2560728..2560801) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg2 tRNA" gene complement(2560728..2560801) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /label="trnSL-Arg2 gene" downshifts complement(2560762) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2560838..2560857) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2560841) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2560871..2560878) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2560932..2561441) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" /label="ysnB CDS" gene complement(2560932..2561441) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /label="ysnB gene" downshifts complement(2560949) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" /label="downshifts" CDS complement(2561457..2562053) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" /label="rdgB CDS" gene complement(2561457..2562053) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /label="rdgB gene" CDS complement(2562066..2562803) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" /label="rph CDS" gene complement(2562066..2562803) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /label="rph gene" promotor_-10 complement(2562885..2562904) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2562901) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2562914..2564014) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" /label="gerM CDS" gene complement(2562914..2564014) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /label="gerM gene" promotor_-35 complement(2562919..2562924) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2562931) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2564037..2564055) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2564053) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2564070..2564075) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2564129..2564947) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" /label="rcmE CDS" gene complement(2564129..2564947) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /label="rcmE gene" downshifts complement(2564141) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2564955..2565395) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" /label="ysmB CDS" gene complement(2564955..2565395) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /label="ysmB gene" promotor_-10 complement(2565438..2565457) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2565447) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2565449..2565591) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2565473..2565477) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2565636) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" CDS complement(2565639..2565863) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" /label="gerE CDS" gene complement(2565639..2565863) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /label="gerE gene" upshifts 2565912 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2565914..2565932 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2565921..2565940) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2565941) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2565954..2565963) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2565979..2566422) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" /label="ysmA CDS" gene complement(2565979..2566422) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /label="ysmA gene" CDS complement(2566483..2567244) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" /label="sdhB CDS" gene complement(2566483..2567244) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /label="sdhB gene" downshifts complement(2566491) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2567247..2569007) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" /label="sdhA CDS" gene complement(2567247..2569007) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /label="sdhA gene" CDS complement(2569041..2569649) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" /label="sdhC CDS" gene complement(2569041..2569649) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /label="sdhC gene" promotor_-35 2569419..2569426 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2569439..2569458 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2569441 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2569650..2569745) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2569735..2569754) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2569745) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="upshifts" S_feature complement(2569747..2570368) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2569769..2569776) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2569884..2569888 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2569898..2569998 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2569905..2569924 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2569914 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" CDS 2569942..2570388 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" /label="yslB CDS" gene 2569942..2570388 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /label="yslB gene" upshifts 2569958 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" downshifts 2570376 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2570414) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" /label="downshifts" CDS complement(2570432..2571658) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" /label="lysCA CDS" CDS complement(2570432..2570923) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" /label="lysCB CDS" gene complement(2570432..2571658) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /label="lysCA gene" gene complement(2570432..2570923) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /label="lysCB gene" downshifts complement(2571772) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" /label="downshifts" misc_RNA complement(2571784..2571963) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" /label="kswC RNA" gene complement(2571784..2571963) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /label="kswC gene" downshifts complement(2571816) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2571988..2572007) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2571995) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="upshifts" promotor_-35 complement(2572020..2572027) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2572028..2573800) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" /label="uvrC CDS" gene complement(2572028..2573800) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /label="uvrC gene" promotor_-10 complement(2573827..2573846) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2573841) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="upshifts" promotor_-35 complement(2573860..2573867) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2573930) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" /label="downshifts" CDS complement(2573936..2574250) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" /label="trxA CDS" gene complement(2573936..2574250) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /label="trxA gene" promotor_-10 complement(2574276..2574295) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2574290) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2574292..2574501) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2574311..2574313) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2574395..2574505) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" /label="CDS C-terminal fragment" gene complement(2574395..2574505) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo /label="gene" promotor_-10 complement(2574491..2574509) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2574501) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="upshifts" promotor_-35 complement(2574524..2574530) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2574573..2576060) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" /label="abfB CDS" gene complement(2574573..2576060) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /label="abfB gene" S_feature complement(2576061..2576173) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2576154..2576173) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2576173) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="upshifts" promotor_-35 complement(2576188..2576195) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2576277..2577254) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" /label="etfA CDS" gene complement(2576277..2577254) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /label="etfA gene" downshifts complement(2576285) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2577290..2578063) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" /label="etfB CDS" gene complement(2577290..2578063) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /label="etfB gene" CDS complement(2578078..2578854) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" /label="fadB CDS" gene complement(2578078..2578854) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /label="fadB gene" downshifts 2578143 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" /label="downshifts" CDS complement(2578869..2579453) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" /label="fadR CDS" gene complement(2578869..2579453) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /label="fadR gene" promotor_-10 complement(2579495..2579514) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2579495) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2579527..2579534) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2579558..2581240) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" /label="lcfA CDS" gene complement(2579558..2581240) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /label="lcfA gene" misc_feature complement(2581269..2581288) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2581277) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2581365) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2581429..2581833) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" /label="yshE CDS" gene complement(2581429..2581833) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /label="yshE gene" downshifts complement(2581431) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2581848..2584205) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" /label="mutSB CDS" gene complement(2581848..2584205) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /label="mutSB gene" CDS complement(2584226..2585938) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" /label="polX CDS" gene complement(2584226..2585938) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /label="polX gene" S_feature complement(2585939..2586011) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2586012..2586545) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" /label="yshB CDS" gene complement(2586012..2586545) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /label="yshB gene" CDS complement(2586552..2586809) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" /label="zapA CDS" gene complement(2586552..2586809) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /label="zapA gene" promotor_-10 complement(2586836..2586855) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2586852) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2586867..2586874) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2586892..2586911 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2586899 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="upshifts" CDS 2586943..2587884 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" /label="rnhC CDS" gene 2586943..2587884 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /label="rnhC gene" promotor_-10 complement(2587616..2587635) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2587631) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2587649..2587656) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2587867 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2587899) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2587920..2590334) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" /label="pheT CDS" gene complement(2587920..2590334) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /label="pheT gene" downshifts complement(2587943) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2590350..2591384) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" /label="pheS CDS" gene complement(2590350..2591384) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /label="pheS gene" S_feature complement(2591385..2591705) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2591466..2591672 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" /label="hypothetical protein CDS" gene 2591466..2591672 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /label="gene" S_feature 2591695..2591959 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2591695 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2591700..2591719) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2591702..2591716 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2591705) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2591734..2591737) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2591739..2592485) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" /label="rlmBB CDS" gene complement(2591739..2592485) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /label="rlmBB gene" promotor_-10 complement(2592512..2592531) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2592518..2592524 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2592525) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="upshifts" promotor_-10 2592538..2592549 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2592545..2592551) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2592552 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2592604..2592819 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" /label="sspI CDS" gene 2592604..2592819 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /label="sspI gene" S_feature complement(2592801..2594213) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2592830..2592837 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2592853..2592872 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2592861 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2592888..2593994 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" /label="ysfB CDS" gene 2592888..2593994 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /label="ysfB gene" promotor_-35 2594030..2594033 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2594049..2594068 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2594053 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="upshifts" CDS 2594097..2595509 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" /label="glcD CDS" gene 2594097..2595509 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /label="glcD gene" promotor_-10 complement(2594199..2594218) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2594213) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2594231..2594240) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2595506..2596840 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" /label="glcF CDS" gene 2595506..2596840 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /label="glcF gene" Polymorphism join(2596539,2596541) /Source="geneious" /ID="SNP_BsDelta6_2935628_2935628" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=1035 /Change="C -> T" /Codon_Change="CTC -> CTT" /Coverage=142 /locus_tag="BSU_28690" /Protein_Effect="None" /Reference_Frequency="1.4%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=140 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2596838 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" downshifts complement(2596877) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2596879..2597121) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" /label="ysfE CDS" gene complement(2596879..2597121) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /label="ysfE gene" S_feature complement(2597122..2597293) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2597181..2597351) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" /label="hypothetical protein CDS" gene complement(2597181..2597351) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /label="gene" CDS complement(2597294..2599090) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" /label="cstA CDS" gene complement(2597294..2599090) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /label="cstA gene" promotor_-10 complement(2597396..2597414) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2597414) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2597426..2597434) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2599087 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2599115..2599134) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2599125) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2599149..2599155) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2599185..2599241) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2599209) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2599242..2600744) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" /label="abfA CDS" gene complement(2599242..2600744) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /label="abfA gene" downshifts complement(2600615) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2600719..2600819) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2600759) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2600763..2601608) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" /label="araQ CDS" gene complement(2600763..2601608) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /label="araQ gene" CDS complement(2601609..2602550) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" /label="araP CDS" gene complement(2601609..2602550) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /label="araP gene" CDS complement(2602586..2603887) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" /label="araN CDS" gene complement(2602586..2603887) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /label="araN gene" CDS complement(2603918..2605102) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" /label="egsA CDS" gene complement(2603918..2605102) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /label="egsA gene" CDS complement(2605099..2605917) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" /label="araL CDS" gene complement(2605099..2605917) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /label="araL gene" CDS complement(2605895..2606584) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" /label="araD CDS" gene complement(2605895..2606584) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /label="araD gene" CDS complement(2606601..2608283) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" /label="araB CDS" gene complement(2606601..2608283) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /label="araB gene" CDS complement(2608297..2609787) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" /label="araA CDS" gene complement(2608297..2609787) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /label="araA gene" promotor_-10 complement(2609880..2609899) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2609887) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2609889..2609964) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2609914..2609921) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2609965..2610936) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" /label="abnA CDS" gene complement(2609965..2610936) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /label="abnA gene" S_feature complement(2610937..2611065) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2611050..2611069) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2611065) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2611084..2611087) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2611133..2612218) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" /label="frvX CDS" gene complement(2611133..2612218) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /label="frvX gene" downshifts complement(2611147) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2612244..2612263) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2612267) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2612278..2612285) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2612336..2612345 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2612351 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2612357..2612372 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2612402..2612794 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" /label="ysdB CDS" gene 2612402..2612794 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /label="ysdB gene" downshifts 2612765 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" /label="downshifts" S_feature 2612810..2613116 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2612810..2613079) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" /label="ysdA CDS" gene complement(2612810..2613079) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /label="ysdA gene" downshifts complement(2612826) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" downshifts complement(2612995) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2613073 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" CDS complement(2613136..2613495) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" /label="rplT CDS" gene complement(2613136..2613495) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /label="rplT gene" downshifts complement(2613149) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(2613527..2613727) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" /label="rpmI CDS" gene complement(2613527..2613727) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /label="rpmI gene" CDS complement(2613740..2614261) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" /label="infC CDS" gene complement(2613740..2614261) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /label="infC gene" misc_RNA complement(2614323..2614462) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" /label="mRNA L20 leader attenuator sequence" gene complement(2614323..2614462) /locus_tag="BSU_misc_RNA_47" /label="gene" promotor_-10 complement(2614459..2614478) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2614469) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2614471..2614535) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2614492..2614499) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2614517..2614536) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2614535) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2614552..2614556) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2614654..2614661 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2614675..2614693 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2614675 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="upshifts" CDS 2614707..2615372 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" /label="yscB CDS" gene 2614707..2615372 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /label="yscB gene" downshifts 2615350 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2615404..2616099) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" /label="pftB CDS" gene complement(2615404..2616099) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /label="pftB gene" downshifts complement(2615426) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2615470) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2616121..2616561) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" /label="pftA CDS" gene complement(2616121..2616561) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /label="pftA gene" promotor_-10 complement(2616583..2616602) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2616602) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2616618..2616621) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2616695..2617420) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" /label="lytT CDS" gene complement(2616695..2617420) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /label="lytT gene" downshifts complement(2616724) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" /label="downshifts" CDS complement(2617398..2619179) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" /label="lytS CDS" gene complement(2617398..2619179) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /label="lytS gene" promotor_-35 2619263..2619266 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2619275..2619294) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2619280) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2619281..2619300 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2619288 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2619346..2620128 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" /label="ysaA CDS" gene 2619346..2620128 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /label="ysaA gene" downshifts 2620112 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" downshifts complement(2620162) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2620169..2622100) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" /label="thrS CDS" gene complement(2620169..2622100) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /label="thrS gene" misc_RNA complement(2622144..2622391) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboT RNA" gene complement(2622144..2622391) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /label="tboT gene" promotor_-10 complement(2622147..2622156) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2622147) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2622202) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2622402..2622421) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2622415) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2622417..2622497) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2622437..2622441) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2622498..2623343) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" /label="ytxC CDS" gene complement(2622498..2623343) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /label="ytxC gene" promotor_-10 complement(2623363..2623381) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2623369) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2623397..2623402) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2623422..2624063) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" /label="ytxB CDS" gene complement(2623422..2624063) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /label="ytxB gene" CDS complement(2624097..2625032) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" /label="dnaI CDS" gene complement(2624097..2625032) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /label="dnaI gene" CDS complement(2625060..2626478) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" /label="dnaB CDS" gene complement(2625060..2626478) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /label="dnaB gene" promotor_-10 complement(2626507..2626526) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2626515) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2626541..2626544) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2626593..2627051) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" /label="nrdR CDS" gene complement(2626593..2627051) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /label="nrdR gene" downshifts complement(2626612) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2627052..2627199) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2627190..2627209) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2627199) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="upshifts" S_feature complement(2627201..2627279) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2627224..2627227) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2627324) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" CDS complement(2627325..2627705) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" /label="speD CDS" gene complement(2627325..2627705) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /label="speD gene" S_feature complement(2627706..2627860) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2627840..2627859) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2627847 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2627848..2627867 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2627860) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2627874..2627880) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2627938..2627949) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2627944..2628966) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" /label="gapB CDS" gene complement(2627944..2628966) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /label="gapB gene" upshifts complement(2627945) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2627964..2627970) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2629010..2629029) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2629041) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2629042..2629049) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2629172..2629552) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" /label="ytcD CDS" gene complement(2629172..2629552) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /label="ytcD gene" downshifts complement(2629196) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(2629553..2629683) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2629608..2629612 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2629628..2629647 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2629629..2629735 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2629629 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2629673..2629692) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2629683) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2629707..2629714) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2629736..2630926 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" /label="ytbD CDS" gene 2629736..2630926 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /label="ytbD gene" promotor_-10 complement(2630558..2630576) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2630574) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2630592..2630597) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2630950..2631792 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" /label="ytbE CDS" gene 2630950..2631792 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /label="ytbE gene" promotor_-35 2631565..2631570 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2631586..2631604 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2631587 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2631785 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2631825) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2631834..2632427) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" /label="coaE CDS" gene complement(2631834..2632427) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /label="coaE gene" CDS complement(2632443..2633075) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" /label="spcF CDS" gene complement(2632443..2633075) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /label="spcF gene" S_feature complement(2633076..2633240) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2633241..2634071) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" /label="mutM CDS" gene complement(2633241..2634071) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /label="mutM gene" CDS complement(2634094..2636736) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" /label="polA CDS" gene complement(2634094..2636736) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /label="polA gene" promotor_-10 complement(2636791..2636810) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2636800) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2636824..2636831) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2636860..2636979) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2636903) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2636980..2638719) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" /label="phoR CDS" gene complement(2636980..2638719) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /label="phoR gene" CDS complement(2638712..2639434) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" /label="phoP CDS" gene complement(2638712..2639434) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /label="phoP gene" promotor_-10 complement(2639502..2639521) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2639512) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2639514..2639614) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2639535..2639541) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2639646..2640584) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" /label="mdh CDS" gene complement(2639646..2640584) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /label="mdh gene" downshifts complement(2639659) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2640628..2641899) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" /label="icd CDS" gene complement(2640628..2641899) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /label="icd gene" misc_feature complement(2641684..2641703) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2641696) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2641900..2641982) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2641982) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="upshifts" S_feature complement(2641984..2642062) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2641984..2642003) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2642019..2642023) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2642063..2643181) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" /label="citZ CDS" gene complement(2642063..2643181) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /label="citZ gene" downshifts 2642676 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" misc_feature 2643023..2643026 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2643031 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2643160 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2643182..2643388) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2643356..2643368 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2643367 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2643374..2643393) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2643388) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2643408..2643412) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2643508) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" /label="downshifts" CDS complement(2643515..2643979) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" /label="ytwI CDS" gene complement(2643515..2643979) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /label="ytwI gene" promotor_-10 complement(2643992..2644011) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2644006) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2644008..2645193) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2644008..2644013 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2644024..2644032) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2644028..2644046 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2644034 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="upshifts" CDS 2644076..2645191 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" /label="ytvI CDS" gene 2644076..2645191 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /label="ytvI gene" downshifts 2645162 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2645224..2645607) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" /label="ytzA CDS" gene complement(2645224..2645607) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /label="ytzA gene" downshifts complement(2645238) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2645608..2645699) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2645700..2647457) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" /label="pyk CDS" gene complement(2645700..2647457) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /label="pyk gene" CDS complement(2647500..2648459) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" /label="pfkA CDS" gene complement(2647500..2648459) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /label="pfkA gene" S_feature complement(2648460..2648561) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2648550..2648569) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2648561) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2648585..2648589) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2648643..2649620) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" /label="accA CDS" gene complement(2648643..2649620) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /label="accA gene" downshifts complement(2648670) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2649605..2650477) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" /label="accD CDS" gene complement(2649605..2650477) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /label="accD gene" promotor_-35 2650439..2650444 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2650460..2650478 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2650464..2651638 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2650464 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2650478..2650561) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2650550..2650569) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2650561) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2650563..2650715) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2650585..2650589) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2650717..2650811) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2650760) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" /label="downshifts" CDS complement(2650812..2652044) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" /label="maeB CDS" gene complement(2650812..2652044) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /label="maeB gene" S_feature complement(2652045..2652161) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2652149..2652168) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2652161) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" CDS complement(2652181..2655528) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" /label="dnaEC CDS" gene complement(2652181..2655528) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /label="dnaEC gene" promotor_-35 complement(2652182..2652189) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2653193..2653202 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2653214..2653229 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2653214 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2653402..2653421) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2653421) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2653435..2653442) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2655559..2655578) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2655577) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" promotor_-35 complement(2655592..2655599) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2655617..2655622 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2655634 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="upshifts" promotor_-10 2655638..2655656 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2655668..2656009 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" /label="ytrH CDS" gene 2655668..2656009 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /label="ytrH gene" CDS 2656006..2656509 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" /label="ytrI CDS" gene 2656006..2656509 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /label="ytrI gene" promotor_-35 2656542..2656545 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2656560..2656579 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2656560 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" CDS 2656611..2656802 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" /label="ytzJ CDS" gene 2656611..2656802 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /label="ytzJ gene" downshifts complement(2656612) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" /label="downshifts" downshifts 2656778 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2656820..2657761) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" /label="nrnA CDS" gene complement(2656820..2657761) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /label="nrnA gene" S_feature 2656823..2657194 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2656855) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2657163..2657172 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2657186..2657205 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2657196..2657590 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2657196 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2657552..2657558 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2657574..2657593 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2657592..2657891 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2657592 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2657780..2657799) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2657796) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2657798..2658212) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2657814..2657817) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2657892..2658194 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" /label="ytpI CDS" gene 2657892..2658194 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /label="ytpI gene" S_feature 2658195..2659990 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2658213..2659532) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" /label="ytoI CDS" gene complement(2658213..2659532) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /label="ytoI gene" promotor_-10 complement(2659558..2659577) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2659579) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2659592..2659597) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2659708..2660610) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" /label="ytnM CDS" gene complement(2659708..2660610) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /label="ytnM gene" CDS complement(2660629..2661879) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" /label="sndA CDS" gene complement(2660629..2661879) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /label="sndA gene" CDS complement(2661897..2662589) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" /label="ribR CDS" gene complement(2661897..2662589) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /label="ribR gene" CDS complement(2662636..2663964) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" /label="cmoJ CDS" gene complement(2662636..2663964) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /label="cmoJ gene" CDS complement(2663961..2664242) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" /label="cmoI CDS" gene complement(2663961..2664242) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /label="cmoI gene" CDS complement(2664257..2665261) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" /label="cmoO CDS" gene complement(2664257..2665261) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /label="cmoO gene" CDS complement(2665258..2666037) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" /label="tcyN CDS" gene complement(2665258..2666037) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /label="tcyN gene" CDS complement(2666034..2666741) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" /label="tcyM CDS" gene complement(2666034..2666741) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /label="tcyM gene" CDS complement(2666771..2667490) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" /label="tcyL CDS" gene complement(2666771..2667490) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /label="tcyL gene" promotor_-35 2667316..2667323 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2667338..2667357 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2667338 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2667512..2668324) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" /label="tcyK CDS" gene complement(2667512..2668324) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /label="tcyK gene" CDS complement(2668338..2669147) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" /label="tcyJ CDS" gene complement(2668338..2669147) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /label="tcyJ gene" CDS complement(2669161..2669697) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" /label="snaA CDS" gene complement(2669161..2669697) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /label="snaA gene" promotor_-35 2669734..2669741 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2669752..2669771) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2669755..2669774 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2669758..2669849 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2669758 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2669768) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2669785..2669792) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2669850..2670776 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" /label="ascR CDS" gene 2669850..2670776 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /label="ascR gene" S_feature complement(2670252..2670781) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2670826) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" /label="downshifts" CDS complement(2670827..2671510) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" /label="ytkL CDS" gene complement(2670827..2671510) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /label="ytkL gene" S_feature complement(2671511..2671572) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2671573..2672340) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" /label="ytkK CDS" gene complement(2671573..2672340) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /label="ytkK gene" promotor_-10 complement(2672385..2672404) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2672407) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2672420..2672422) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2672467..2672703) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" /label="ytzD CDS" gene complement(2672467..2672703) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /label="ytzD gene" downshifts 2672552 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" /label="downshifts" downshifts complement(2672572) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" /label="downshifts" CDS complement(2672663..2674048) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" /label="argH CDS" gene complement(2672663..2674048) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /label="argH gene" CDS complement(2674045..2675256) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" /label="argG CDS" gene complement(2674045..2675256) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /label="argG gene" S_feature complement(2675257..2675334) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2675327..2675346) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2675333) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2675361..2675368) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2675426..2675938) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" /label="moaB CDS" gene complement(2675426..2675938) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /label="moaB gene" downshifts complement(2675444) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2675964..2675983) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2675972) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2675997..2676004) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2676023..2677210) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" /label="ackA CDS" gene complement(2676023..2677210) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /label="ackA gene" downshifts complement(2676038) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" /label="downshifts" S_feature complement(2677211..2677315) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2677300..2677319) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2677315) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2677317..2677446) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2677335..2677339) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2677383..2677586) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" /label="hypothetical protein CDS" gene complement(2677383..2677586) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /label="gene" promotor_-10 complement(2677444..2677455) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2677446) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2677470..2677476) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2677558..2678547) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" /label="ytxK CDS" gene complement(2677558..2678547) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /label="ytxK gene" downshifts complement(2677576) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2678608..2679111) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" /label="tpx CDS" gene complement(2678608..2679111) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /label="tpx gene" downshifts complement(2678614) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" /label="downshifts" promotor_no_box 2678828..2678928 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2678888 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2679107 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2679134..2679153) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2679150) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2679167..2679174) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2679221..2679676) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" /label="gerW CDS" gene complement(2679221..2679676) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /label="gerW gene" downshifts complement(2679249) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" CDS complement(2679690..2680370) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" /label="ytfI CDS" gene complement(2679690..2680370) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /label="ytfI gene" upshifts complement(2679782) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="upshifts" promotor_-10 complement(2679789..2679800) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2679815..2679821) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2680108) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2680383..2680401) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2680397) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="upshifts" promotor_-35 complement(2680416..2680421) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2680445..2680939) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" /label="yteJ CDS" gene complement(2680445..2680939) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /label="yteJ gene" downshifts complement(2680460) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2680952..2681959) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" /label="sppA CDS" gene complement(2680952..2681959) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /label="sppA gene" promotor_-10 complement(2681983..2681998) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2682000) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2682002..2682081) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2682010..2682019) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2682059..2682078 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2682069 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2682074..2682093) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2682078..2682144 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2682081) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2682109..2682113) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2682145..2682948 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" /label="ppnKB CDS" gene 2682145..2682948 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /label="ppnKB gene" downshifts 2682878 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" /label="downshifts" downshifts 2682936 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2682980..2684569) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" /label="ytcJ CDS" gene complement(2682980..2684569) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /label="ytcJ gene" downshifts complement(2682989) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2684589..2686178) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" /label="ytcI CDS" gene complement(2684589..2686178) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /label="ytcI gene" promotor_-10 complement(2686224..2686241) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2686229) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2686257..2686263) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2686356) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2686357..2686566) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" /label="sspA CDS" gene complement(2686357..2686566) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /label="sspA gene" promotor_-35 2686562..2686566 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2686566 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2686575..2686589 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2686587..2686598) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2686598) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2686613..2686619) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2686660..2687865) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" /label="trmG CDS" gene complement(2686660..2687865) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /label="trmG gene" CDS complement(2687869..2689014) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" /label="iscSB CDS" gene complement(2687869..2689014) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /label="iscSB gene" S_feature complement(2689015..2690158) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2689101..2689108 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2689119..2689208 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2689119 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2689121..2689140 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2689209..2690546 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" /label="braB CDS" gene 2689209..2690546 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /label="braB gene" promotor_-10 complement(2690144..2690163) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2690158) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2690178..2690185) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2690522 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2690641..2692329) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" /label="ezrA CDS" gene complement(2690641..2692329) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /label="ezrA gene" downshifts complement(2690642) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2692330..2692435) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2692412..2692420 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2692423..2692442) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2692431..2692450 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2692435) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" upshifts 2692435 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2692436..2692525 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2692437..2692996) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2692458..2692460) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2692526..2693332 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" /label="hisK CDS" gene 2692526..2693332 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /label="hisK gene" promotor_-10 complement(2693000..2693019) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2693013) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2693031..2693038) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2693282..2693328) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2693304) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2693329..2693952) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" /label="refZ CDS" gene complement(2693329..2693952) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /label="refZ gene" S_feature 2693333..2693675 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2693653..2693660 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2693675..2693694 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2693677..2693820 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2693677 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2693792..2693796 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2693812..2693831 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2693822..2693952 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2693822 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2693954..2694078 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2693954 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2693968..2693986) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2693970..2693989 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2693986) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2693997..2694005) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2694079..2694570 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" /label="msrC CDS" gene 2694079..2694570 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /label="msrC gene" downshifts 2694549 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2694608..2696347) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" /label="dgcP CDS" gene complement(2694608..2696347) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /label="dgcP gene" downshifts complement(2694626) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" promotor_-35 2695821..2695828 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2695842..2695860 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2695845 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="upshifts" S_feature 2695847..2696442 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2696377..2696396) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2696385) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2696387..2697220) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2696423..2696430 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2696444..2696641 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2696444..2696463 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2696444 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2696501..2696633 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" /label="ldsD RNA" gene 2696501..2696633 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /label="ldsD gene" CDS 2696642..2697244 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" /label="rpsD CDS" gene 2696642..2697244 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /label="rpsD gene" downshifts 2697167 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(2697222..2697441) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2697230 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" /label="downshifts" downshifts complement(2697265) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2697277 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2697322..2697495 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2697437..2697455) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2697449) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="upshifts" downshifts 2697453 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2697470..2697476) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2697515..2698783) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" /label="tyrS CDS" gene complement(2697515..2698783) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /label="tyrS gene" downshifts complement(2697541) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" misc_RNA complement(2698807..2699080) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" /label="tboY RNA" gene complement(2698807..2699080) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /label="tboY gene" S_feature complement(2698828..2698971) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2698871) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2699078..2699097) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2699090) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2699110..2699117) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2699125..2700843) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" /label="acsA CDS" gene complement(2699125..2700843) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /label="acsA gene" promotor_-35 2700857..2700864 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2700871..2700890) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2700879..2700898 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2700885 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2700894) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2700904..2700910) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2700927..2700934 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2700948..2700967 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2700951 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2701004..2701636 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" /label="acuA CDS" gene 2701004..2701636 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /label="acuA gene" promotor_-35 2701209..2701217 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2701231..2701250 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2701237 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2701663..2702307 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" /label="acuB CDS" gene 2701663..2702307 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /label="acuB gene" CDS 2702304..2703467 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" /label="acuC CDS" gene 2702304..2703467 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /label="acuC gene" downshifts 2703458 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2703478..2704206) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" /label="motS CDS" gene complement(2703478..2704206) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /label="motS gene" downshifts complement(2703514) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2704196..2705014) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" /label="motP CDS" gene complement(2704196..2705014) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /label="motP gene" CDS complement(2705077..2706081) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" /label="ccpA CDS" gene complement(2705077..2706081) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /label="ccpA gene" downshifts complement(2705094) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(2706116..2706135) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2706131) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2706133..2706241) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2706241..2706260) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2706241) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2706243..2706308) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2706274..2706280) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2706354) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2706357..2707433) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" /label="aroX CDS" gene complement(2706357..2707433) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /label="aroX gene" promotor_-10 complement(2707474..2707493) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2707494) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="upshifts" S_feature complement(2707496..2707596) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2707508..2707515) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2707530 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2707584..2707603) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2707596) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2707617..2707623) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2707669..2707995) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" /label="brxJ CDS" gene complement(2707669..2707995) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /label="brxJ gene" downshifts complement(2707678) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2708019..2708474) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" /label="ytxH CDS" gene complement(2708019..2708474) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /label="ytxH gene" CDS complement(2708505..2708927) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" /label="ytxG CDS" gene complement(2708505..2708927) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /label="ytxG gene" promotor_-10 complement(2708948..2708966) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2708961) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2708980..2708986) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2709000..2709018) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2709009) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="upshifts" promotor_-35 complement(2709029..2709037) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2709089..2710387) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" /label="murC CDS" gene complement(2709089..2710387) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /label="murC gene" downshifts complement(2709098) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2710412..2710431) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2710413) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2710415..2710611) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2710444..2710453) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2710594..2710613) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2710611) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2710625..2710631) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2710637..2713495) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" /label="sftA CDS" gene complement(2710637..2713495) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /label="sftA gene" promotor_-10 complement(2713529..2713548) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2713539) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="upshifts" promotor_-35 complement(2713564..2713568) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2713638) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" /label="downshifts" CDS complement(2713655..2714260) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" /label="ytpR CDS" gene complement(2713655..2714260) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /label="ytpR gene" CDS complement(2714276..2715085) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" /label="ytpQ CDS" gene complement(2714276..2715085) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /label="ytpQ gene" CDS complement(2715100..2715423) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" /label="ytpP CDS" gene complement(2715100..2715423) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /label="ytpP gene" S_feature complement(2715424..2715562) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2715462..2715578) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" /label="hypothetical protein CDS" gene complement(2715462..2715578) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /label="gene" promotor_-10 complement(2715549..2715568) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2715562) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="upshifts" promotor_-35 2715570..2715577 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2715592..2715611 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2715597 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="upshifts" CDS 2715658..2716104 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" /label="ytoQ CDS" gene 2715658..2716104 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /label="ytoQ gene" S_feature 2716105..2716833 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2716159..2717232) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" /label="ytoP CDS" gene complement(2716159..2717232) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /label="ytoP gene" downshifts complement(2716178) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2717254..2717273) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2717258) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2717287..2717294) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2717329..2717332 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2717347..2717366 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2717352 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="upshifts" CDS 2717391..2717708 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" /label="ytzB CDS" gene 2717391..2717708 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /label="ytzB gene" downshifts 2717708 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2717761..2719461) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" /label="maeC CDS" gene complement(2717761..2719461) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /label="maeC gene" downshifts complement(2717780) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2719493..2719511) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2719500) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2719526..2719532) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2719543..2720313) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" /label="ytnP CDS" gene complement(2719543..2720313) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /label="ytnP gene" S_feature complement(2720314..2720402) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2720400..2720419) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2720402) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2720435..2720439) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2720459..2721100) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" /label="trmB CDS" gene complement(2720459..2721100) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /label="trmB gene" downshifts complement(2720469) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(2720534) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2721126..2721145) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2721135) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2721137..2721585) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2721161..2721165) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2721244..2721250 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2721265..2721276 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2721272 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="upshifts" CDS 2721307..2721585 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" /label="ytzH CDS" gene 2721307..2721585 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /label="ytzH gene" S_feature 2721586..2721756 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2721586..2722200) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" /label="ytmP CDS" gene complement(2721586..2722200) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /label="ytmP gene" downshifts 2721734 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2722201..2722536) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2722528..2722547) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2722536) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2722562..2722569) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2722563..2724719) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" /label="amyX CDS" gene complement(2722563..2724719) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /label="amyX gene" Polymorphism join(2724260,2724262) /Source="geneious" /ID="SNP_BsDelta6_3063349_3063349" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=459 /Change="A -> G" /Codon_Change="GTT -> GTC" /Coverage=168 /locus_tag="BSU_29930" /Protein_Effect="None" /Reference_Frequency="1.2%" /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=165 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2724745..2725674) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" /label="ytlR CDS" gene complement(2724745..2725674) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /label="ytlR gene" CDS complement(2725723..2726637) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" /label="ytlQ CDS" gene complement(2725723..2726637) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /label="ytlQ gene" promotor_-10 complement(2726400..2726418) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2726408) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2726432..2726438) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2726663..2727214) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" /label="ytlP CDS" gene complement(2726663..2727214) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /label="ytlP gene" misc_feature 2727077..2727096 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2727080 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2727237..2727256) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2727249) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2727272..2727275) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2727297..2727304 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2727315..2727334 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2727318..2727329) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2727322 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2727332) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2727343..2727349) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2727363..2728298 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" /label="ytkP CDS" gene 2727363..2728298 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /label="ytkP gene" downshifts 2728274 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(2728332..2729723) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" /label="ytjP CDS" gene complement(2728332..2729723) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /label="ytjP gene" downshifts complement(2728344) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature complement(2729724..2730164) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2729750..2729755 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2729769..2729788 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2729782 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="upshifts" CDS 2729820..2731118 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" /label="pbuO CDS" gene 2729820..2731118 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /label="pbuO gene" promotor_-10 complement(2730141..2730160) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2730164) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2730175..2730181) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2731105 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2731158..2732315) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" /label="ythQ CDS" gene complement(2731158..2732315) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /label="ythQ gene" downshifts complement(2731183) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2731431..2731436 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2731451..2731469 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2731459 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2732312..2733022) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" /label="ythP CDS" gene complement(2732312..2733022) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /label="ythP gene" promotor_-10 complement(2733036..2733051) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2733053) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2733063..2733072) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2733079..2733080 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2733092..2733197 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2733092 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2733100..2733110 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2733163..2733169 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2733184..2733203 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2733199..2733312 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2733199 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2733313..2733534 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" /label="ytzE CDS" gene 2733313..2733534 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /label="ytzE gene" downshifts 2733517 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" /label="downshifts" downshifts 2733586 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2733655..2734374) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" /label="rsuA CDS" gene complement(2733655..2734374) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /label="rsuA gene" downshifts complement(2733669) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2734440) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" /label="downshifts" CDS complement(2734443..2736077) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" /label="murJ CDS" gene complement(2734443..2736077) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /label="murJ gene" misc_feature complement(2736109..2736128) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2736125) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2736195..2736199 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2736215..2736234 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2736233 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2736279..2737541 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" /label="ytfP CDS" gene 2736279..2737541 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /label="ytfP gene" S_feature 2737542..2737640 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2737614..2737620 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2737636..2737654 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2737642..2737729 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2737642 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2737730..2739268 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" /label="opuD CDS" gene 2737730..2739268 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /label="opuD gene" downshifts 2739248 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2739305..2739487) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" /label="yteV CDS" gene complement(2739305..2739487) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /label="yteV gene" downshifts complement(2739324) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2739502..2739520) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2739522) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2739536..2739541) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2739555..2740223) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" /label="rmgU CDS" gene complement(2739555..2740223) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /label="rmgU gene" CDS complement(2740245..2741531) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" /label="rmgT CDS" gene complement(2740245..2741531) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /label="rmgT gene" CDS complement(2741543..2742046) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" /label="rmgS CDS" gene complement(2741543..2742046) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /label="rmgS gene" CDS complement(2742043..2743164) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" /label="rmgQ CDS" gene complement(2742043..2743164) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /label="rmgQ gene" CDS complement(2743172..2744137) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" /label="rmgP CDS" gene complement(2743172..2744137) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /label="rmgP gene" upshifts complement(2744163) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2744164..2744183) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2744198..2744205) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2744293..2744300 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2744313 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2744316..2744335 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2744353..2746671 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" /label="rmgR CDS" gene 2744353..2746671 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /label="rmgR gene" downshifts 2746661 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" CDS complement(2746712..2748208) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" /label="ytcQ CDS" gene complement(2746712..2748208) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /label="ytcQ gene" downshifts complement(2746714) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2748233..2749093) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" /label="ytcP CDS" gene complement(2748233..2749093) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /label="ytcP gene" promotor_-10 complement(2749169..2749188) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2749178) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2749204..2749211) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2749300..2750061) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" /label="ytbQ CDS" gene complement(2749300..2750061) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /label="ytbQ gene" downshifts complement(2749329) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2750062..2750137) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2750138..2751325) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" /label="bioI CDS" gene complement(2750138..2751325) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /label="bioI gene" CDS complement(2751394..2752401) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" /label="bioB CDS" gene complement(2751394..2752401) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /label="bioB gene" CDS complement(2752404..2753099) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" /label="bioD CDS" gene complement(2752404..2753099) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /label="bioD gene" CDS complement(2753096..2754265) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" /label="bioFC CDS" gene complement(2753096..2754265) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /label="bioFC gene" promotor_-35 2753132..2753139 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2753154..2753173 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2753172 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2754255..2755601) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" /label="bioK CDS" gene complement(2754255..2755601) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /label="bioK gene" promotor_-35 2754671..2754675 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2754690 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2754691..2754709 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2755591..2756367) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" /label="bioW CDS" gene complement(2755591..2756367) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /label="bioW gene" S_feature complement(2756368..2756460) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2756446..2756465) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2756460) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2756480..2756487) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2756577..2757476) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" /label="ytaP CDS" gene complement(2756577..2757476) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /label="ytaP gene" promotor_-10 complement(2757499..2757517) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2757516) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2757528..2757536) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2757606..2757613 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2757629..2757648 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2757635 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2757694..2758728 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" /label="msmR CDS" gene 2757694..2758728 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /label="msmR gene" promotor_-35 2758677..2758684 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2758699..2758707 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2758716 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2758762..2760042 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" /label="msmE CDS" gene 2758762..2760042 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /label="msmE gene" CDS 2760035..2760946 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" /label="msmF CDS" gene 2760035..2760946 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /label="msmF gene" CDS 2760943..2761773 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" /label="msmG CDS" gene 2760943..2761773 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /label="msmG gene" promotor_-35 2761746..2761750 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2761766..2761785 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2761774 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2761793..2763091 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" /label="melA CDS" gene 2761793..2763091 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /label="melA gene" downshifts 2763072 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2763113..2763424) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" /label="ytwF CDS" gene complement(2763113..2763424) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /label="ytwF gene" downshifts complement(2763124) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2763448..2763467) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2763456) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2763482..2763489) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2763490 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS complement(2763541..2765955) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" /label="leuS CDS" gene complement(2763541..2765955) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /label="leuS gene" downshifts complement(2763545) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" S_feature complement(2765956..2766051) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2766065..2766279) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" /label="tboL RNA" gene complement(2766065..2766279) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /label="tboL gene" downshifts complement(2766096) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2766291..2766310) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2766312) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2766316..2766321 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2766325..2766330) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2766337..2766355 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2766350..2766790 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2766350 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2766382..2766717) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" /label="ytvB CDS" gene complement(2766382..2766717) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /label="ytvB gene" S_feature complement(2766712..2766976) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2766961..2766980) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2766976) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="upshifts" promotor_-35 complement(2766995..2767002) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2767015..2767022 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2767036..2767055 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2767052 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2767054..2767121 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2767122..2767907 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" /label="blrA CDS" gene 2767122..2767907 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /label="blrA gene" S_feature 2767908..2767964 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2768144..2769337) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" /label="yttB CDS" gene complement(2768144..2769337) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /label="yttB gene" downshifts complement(2768164) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2769338..2769436) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2769417..2769436) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2769436) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2769450..2769457) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2769474..2769477 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2769492..2769511 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2769496 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="upshifts" CDS 2769526..2770272 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" /label="yttA CDS" gene 2769526..2770272 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /label="yttA gene" downshifts 2770167 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" /label="downshifts" downshifts 2770266 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2770309..2772249) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" /label="bceB CDS" gene complement(2770309..2772249) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /label="bceB gene" downshifts complement(2770320) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2772239..2773000) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" /label="bceA CDS" gene complement(2772239..2773000) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /label="bceA gene" misc_feature complement(2773024..2773042) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2773043) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2773102..2774106) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" /label="bceS CDS" gene complement(2773102..2774106) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /label="bceS gene" downshifts complement(2773141) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2774099..2774794) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" /label="bceR CDS" gene complement(2774099..2774794) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /label="bceR gene" promotor_-10 complement(2774818..2774836) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2774830) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2774852..2774855) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2774891..2776201) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" /label="ytrF CDS" gene complement(2774891..2776201) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /label="ytrF gene" downshifts complement(2774913) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" /label="downshifts" CDS complement(2776191..2776886) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" /label="ytrE CDS" gene complement(2776191..2776886) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /label="ytrE gene" CDS complement(2776901..2777878) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" /label="ytrD CDS" gene complement(2776901..2777878) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /label="ytrD gene" CDS complement(2777908..2778894) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" /label="ytrC CDS" gene complement(2777908..2778894) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /label="ytrC gene" promotor_-35 2778764..2778773 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2778780 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2778786..2778801 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2778888..2779766) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" /label="ytrB CDS" gene complement(2778888..2779766) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /label="ytrB gene" CDS complement(2779759..2780151) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" /label="ytrA CDS" gene complement(2779759..2780151) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /label="ytrA gene" S_feature complement(2780152..2780396) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2780185..2780322) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" /label="conserved protein of unknown function CDS" gene complement(2780185..2780322) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /label="gene" downshifts 2780320 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2780391..2780410) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2780396) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2780424..2780431) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2780477..2780749) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" /label="ytzC CDS" gene complement(2780477..2780749) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /label="ytzC gene" downshifts complement(2780484) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2780789..2780800) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2780793..2780801 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2780793) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="upshifts" upshifts 2780804 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2780815..2780821) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2780815..2780833 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2780844..2780849 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2780863..2780882 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2780870 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="upshifts" CDS 2780911..2781879 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" /label="ytqA CDS" gene 2780911..2781879 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /label="ytqA gene" CDS 2781876..2782460 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" /label="ytqB CDS" gene 2781876..2782460 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /label="ytqB gene" downshifts 2782424 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2782450..2783553) /gene="tbcS" /locus_tag="BSU_30500" /old_locus_tag="BSU30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /translation="MTVPEHPFGLMAKVYRDIFPLVHQELDIWKQKSESIHNSELKAQ ATASIRDKTFHCEGGGILALLSGSQKQKCVEFIIAYQTISDYLDNLCDRSTSLDPQDF RMLHASMQDALTVGAELQNYYQFREEQDDSGYLHELVKTCQRVLGSIEHYDMIKPYLL ELCGYYCDLQVHKHVIEHERVPRLEKWFTQYESELPEMEWYEFSACAGSTLGIFCLVA YSFQPDFTESTAKKIRDSYFPYIQGLHILLDYLIDQEEDLLEGDLNFCSYYQSHEEMM DRLEHFIHKADEHLQGIPHENFHRLINRGLLGVYLSDDKVAGQKEMGRLAKKLIKASG KTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC*" /label="tbcS CDS" gene complement(2782450..2783553) /gene="tbcS" /locus_tag="BSU_30500" /old_locus_tag="BSU30500" /label="tbcS gene" downshifts complement(2782491) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2783574..2784353) /gene="ytpA" /locus_tag="BSU_30510" /old_locus_tag="BSU30510" /EC_number="3.1.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11796336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11796336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospholipase component of bacilysocin synthesisor export" /protein_id="NP_390929.1" /db_xref="EnsemblGenomes-Gn:BSU30510" /db_xref="EnsemblGenomes-Tr:CAB15029" /db_xref="GOA:O34705" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13900" /db_xref="UniProtKB/Swiss-Prot:O34705" /translation="MWTWKADRPVAVIVIIHGASEYHGRYKWLIEMWRSSGYHVVMGD LPGQGTTTRARGHIRSFQEYIDEVDAWIDKARTFDLPVFLLGHSMGGLVAIEWVKQQR NPRITGIILSSPCLGLQIKVNKALDLASKGLNVIAPSLKVDSGLSIDMATRNEDVIEA DQNDSLYVRKVSVRWYRELLKTIESAMVPTEAFLKVPLLVMQAGDDKLVDKTMVIKWF NGVASHNKAYREWEGLYHEIFNEPEREDVFKAARAFTDQYI*" /label="ytpA CDS" gene complement(2783574..2784353) /gene="ytpA" /locus_tag="BSU_30510" /old_locus_tag="BSU30510" /label="ytpA gene" promotor_-35 2783996..2784003 /Source="Nicolas_upshift_promotors" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2784018..2784037 /Source="Nicolas_upshift_promotors" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2784035 /Source="Nicolas_upshifts" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2784354..2784933) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" CDS 2784402..2784917 /gene="ytoA" /locus_tag="BSU_30520" /old_locus_tag="BSU30520" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22868757; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of the carbonic anhydrase family" /protein_id="NP_390930.1" /db_xref="EnsemblGenomes-Gn:BSU30520" /db_xref="EnsemblGenomes-Tr:CAB15030" /db_xref="GOA:O34696" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG13896" /db_xref="UniProtKB/Swiss-Prot:O34696" /translation="MIYPYKEHKPDIHPTAFIADNATITGDVVIGEQSSIWFSVVIRG DVAPTRIGNRVNIQDLSCLHQSPNKTLLIEDDATIGHQVTLHSAVIRKNALIGMGSII LDGAEIGEGAFIGAGSLVPPGKIIPPGHLAFGRPAKVIRPLTEEDRKDMQRIRSEYVE KGQYYKFLQQT*" /label="ytoA CDS" gene 2784402..2784917 /gene="ytoA" /locus_tag="BSU_30520" /old_locus_tag="BSU30520" /label="ytoA gene" promotor_-10 complement(2784924..2784943) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2784933) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2784935..2785069) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2784955..2784962) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2785044..2785063) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2785069) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2785162..2786553) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" /label="ytnA CDS" gene complement(2785162..2786553) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /label="ytnA gene" downshifts complement(2785170) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(2786554..2786688) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2786689..2788587) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" /label="asnB CDS" gene complement(2786689..2788587) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /label="asnB gene" promotor_-35 2787745..2787751 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2787766..2787777 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2787778 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2788588..2788711) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2788737..2789939) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" /label="metK CDS" gene complement(2788737..2789939) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /label="metK gene" downshifts complement(2788756) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2789982..2789993) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2789988) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2789990..2790106) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2790007..2790013) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2790107..2790245) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswG RNA" gene complement(2790107..2790245) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /label="mswG gene" downshifts 2790205 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2790254..2790273) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2790269) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="upshifts" promotor_-35 complement(2790290..2790294) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2790366..2790373 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2790385 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2790387..2790406 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2790442..2792025 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" /label="pckA CDS" gene 2790442..2792025 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /label="pckA gene" downshifts 2792014 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" /label="downshifts" CDS complement(2792064..2792306) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" /label="ytmB CDS" gene complement(2792064..2792306) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /label="ytmB gene" downshifts complement(2792078) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2792358..2793131) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" /label="ytmA CDS" gene complement(2792358..2793131) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /label="ytmA gene" S_feature complement(2793132..2793222) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2793198..2793207 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2793211..2793230) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2793219 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2793220..2793239 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2793224) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2793245..2793252) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2793282..2794286 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" /label="ytlA CDS" gene 2793282..2794286 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /label="ytlA gene" CDS 2794299..2795081 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" /label="ytlC CDS" gene 2794299..2795081 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /label="ytlC gene" S_feature complement(2794303..2795851) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2795056..2795868 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" /label="ytlD CDS" gene 2795056..2795868 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /label="ytlD gene" downshifts 2795853 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(2795895..2796371) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" /label="rppG CDS" gene complement(2795895..2796371) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /label="rppG gene" downshifts complement(2795896) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" /label="downshifts" misc_feature complement(2796401..2796420) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2796414) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2796416..2796550) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2796550) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2796552..2796563) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2796578..2796584) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2796580..2796984) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" /label="ytkC CDS" gene complement(2796580..2796984) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /label="ytkC gene" promotor_-10 complement(2797012..2797031) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2797029) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2797031..2797117) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2797044..2797053) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2797150..2797587) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" /label="dps CDS" gene complement(2797150..2797587) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /label="dps gene" downshifts complement(2797162) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2797604..2797622) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2797622) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2797624..2797849) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2797637..2797643) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2797679..2797698 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2797680..2797856 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" /label="ytzI CDS" gene 2797680..2797856 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /label="ytzI gene" upshifts 2797681 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2797850..2798287) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" /label="ytkA CDS" gene complement(2797850..2798287) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /label="ytkA gene" downshifts 2797876 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2798306..2798325) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2798327) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 complement(2798336..2798344) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2798407..2798880) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" /label="luxS CDS" gene complement(2798407..2798880) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /label="luxS gene" downshifts complement(2798416) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" /label="downshifts" downshifts complement(2798503) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" S_feature complement(2798881..2799232) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2798952..2798959 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2798972..2798991 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2798977 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2799009..2799236 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" /label="ytjA CDS" gene 2799009..2799236 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /label="ytjA gene" CDS complement(2799233..2799796) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" /label="ytiB CDS" gene complement(2799233..2799796) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /label="ytiB gene" misc_feature complement(2799821..2799840) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2799836) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2799890..2800138) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" /label="rpmEB CDS" gene complement(2799890..2800138) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /label="rpmEB gene" downshifts complement(2799911) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2800166..2800185) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2800199..2800206) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2800203) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 2800265..2800271 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2800285..2800296 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2800297 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="upshifts" CDS 2800343..2801674 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" /label="ythA CDS" gene 2800343..2801674 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /label="ythA gene" CDS 2801718..2802758 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" /label="ythB CDS" gene 2801718..2802758 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /label="ythB gene" promotor_-35 2802752..2802758 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2802773..2802784 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2802783 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="upshifts" CDS 2802812..2802970 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" /label="ytzL CDS" gene 2802812..2802970 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /label="ytzL gene" downshifts 2802959 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2802989..2803876) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" /label="mntD CDS" gene complement(2802989..2803876) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /label="mntD gene" downshifts complement(2803012) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" CDS complement(2803866..2805173) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" /label="mntC CDS" gene complement(2803866..2805173) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /label="mntC gene" CDS complement(2805179..2805931) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" /label="mntB CDS" gene complement(2805179..2805931) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /label="mntB gene" CDS complement(2805950..2806870) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" /label="mntA CDS" gene complement(2805950..2806870) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /label="mntA gene" promotor_-10 complement(2806906..2806917) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2806907) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2806909..2807000) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2806931..2806937) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2806985 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2806986..2807005) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2806988..2807000 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2807000) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2807002..2807083) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2807020..2807027) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2807083) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="upshifts" promotor_-10 complement(2807092..2807111) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2807125..2807132) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2807150..2808265) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" /label="menC CDS" gene complement(2807150..2808265) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /label="menC gene" downshifts complement(2807193) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2808262..2809722) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" /label="menE CDS" gene complement(2808262..2809722) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /label="menE gene" promotor_-10 complement(2809165..2809183) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2809169) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2809198..2809204) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2809811) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS complement(2809813..2810628) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" /label="menB CDS" gene complement(2809813..2810628) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /label="menB gene" CDS complement(2810663..2811487) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" /label="menH CDS" gene complement(2810663..2811487) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /label="menH gene" promotor_-10 complement(2810745..2810764) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2810745) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2810780..2810783) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2810911) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2810921..2810932) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2810947..2810953) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2811475..2813217) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" /label="menD CDS" gene complement(2811475..2813217) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /label="menD gene" CDS complement(2813214..2814629) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" /label="menF CDS" gene complement(2813214..2814629) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /label="menF gene" S_feature complement(2814630..2814742) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2814722..2814741) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2814742) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="upshifts" S_feature complement(2814744..2814894) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2814757..2814760) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2814855..2814861 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2814875..2814894) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2814875..2814886 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2814883 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2814894) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2814908..2814917) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2814919..2815638 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" /label="yteA CDS" gene 2814919..2815638 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /label="yteA gene" S_feature complement(2814989..2815646) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2815627 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2815647..2816465) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" /label="ytdA CDS" gene complement(2815647..2816465) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /label="ytdA gene" promotor_-10 complement(2816486..2816505) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2816500) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2816520..2816528) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2816566..2816574 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2816587..2816606 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2816588 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="upshifts" CDS 2816637..2817923 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" /label="ytcA CDS" gene 2816637..2817923 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /label="ytcA gene" CDS 2817920..2818870 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" /label="ytcB CDS" gene 2817920..2818870 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /label="ytcB gene" CDS 2818873..2820096 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" /label="ytcC CDS" gene 2818873..2820096 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /label="ytcC gene" downshifts complement(2820020) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2820097..2820664 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2820170..2820601) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" /label="cotOO CDS" gene complement(2820170..2820601) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /label="cotOO gene" downshifts complement(2820196) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(2820603..2821658) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" /label="cotS CDS" gene complement(2820603..2821658) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /label="cotS gene" CDS complement(2821673..2822806) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" /label="cotSA CDS" gene complement(2821673..2822806) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /label="cotSA gene" promotor_-10 complement(2822839..2822858) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2822858) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2822871..2822880) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2822944..2822953 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2822967..2822986 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2822969 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="upshifts" CDS 2822996..2824069 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" /label="cotI CDS" gene 2822996..2824069 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /label="cotI gene" promotor_-35 2823293..2823299 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2823310 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2823313..2823324 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2824058 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2824096..2824102 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2824117 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2824118..2824136 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2824149..2824616 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" /label="ytaB CDS" gene 2824149..2824616 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /label="ytaB gene" downshifts 2824588 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2824647..2827043) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" /label="glgP CDS" gene complement(2824647..2827043) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /label="glgP gene" downshifts complement(2824662) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2827030..2828484) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" /label="glgA CDS" gene complement(2827030..2828484) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /label="glgA gene" CDS complement(2828481..2829512) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" /label="glgD CDS" gene complement(2828481..2829512) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /label="glgD gene" CDS complement(2829536..2830678) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" /label="glgC CDS" gene complement(2829536..2830678) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /label="glgC gene" CDS complement(2830675..2832558) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" /label="glgB CDS" gene complement(2830675..2832558) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /label="glgB gene" S_feature 2831384..2832803 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2832590..2832605) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2832603) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2832620..2832625) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2832670) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" /label="downshifts" tRNA complement(2832791..2832862) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Glu tRNA" gene complement(2832791..2832862) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /label="trnB-Glu gene" tRNA complement(2832888..2832978) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser2 tRNA" gene complement(2832888..2832978) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /label="trnB-Ser2 gene" tRNA complement(2832982..2833056) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asn tRNA" gene complement(2832982..2833056) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /label="trnB-Asn gene" tRNA complement(2833067..2833143) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ile2 tRNA" gene complement(2833067..2833143) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /label="trnB-Ile2 gene" tRNA complement(2833159..2833232) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly2 tRNA" gene complement(2833159..2833232) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /label="trnB-Gly2 gene" tRNA complement(2833243..2833318) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-His tRNA" gene complement(2833243..2833318) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /label="trnB-His gene" tRNA complement(2833336..2833411) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Phe tRNA" gene complement(2833336..2833411) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /label="trnB-Phe gene" tRNA complement(2833424..2833500) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asp tRNA" gene complement(2833424..2833500) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /label="trnB-Asp gene" tRNA complement(2833512..2833588) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met2 tRNA" gene complement(2833512..2833588) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /label="trnB-Met2 gene" tRNA complement(2833606..2833698) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser1 tRNA" gene complement(2833606..2833698) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /label="trnB-Ser1 gene" tRNA complement(2833705..2833781) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met3 tRNA" gene complement(2833705..2833781) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /label="trnB-Met3 gene" tRNA complement(2833784..2833860) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met1 tRNA" gene complement(2833784..2833860) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /label="trnB-Met1 gene" tRNA complement(2833880..2833952) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ala tRNA" gene complement(2833880..2833952) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /label="trnB-Ala gene" tRNA complement(2833958..2834034) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Pro tRNA" gene complement(2833958..2834034) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /label="trnB-Pro gene" tRNA complement(2834050..2834126) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Arg tRNA" gene complement(2834050..2834126) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /label="trnB-Arg gene" tRNA complement(2834136..2834221) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu2 tRNA" gene complement(2834136..2834221) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /label="trnB-Leu2 gene" tRNA complement(2834236..2834310) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly1 tRNA" gene complement(2834236..2834310) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /label="trnB-Gly1 gene" tRNA complement(2834316..2834402) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu1 tRNA" gene complement(2834316..2834402) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /label="trnB-Leu1 gene" tRNA complement(2834413..2834488) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Lys tRNA" gene complement(2834413..2834488) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /label="trnB-Lys gene" tRNA complement(2834526..2834601) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Thr tRNA" gene complement(2834526..2834601) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /label="trnB-Thr gene" tRNA complement(2834634..2834709) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Val tRNA" gene complement(2834634..2834709) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /label="trnB-Val gene" rRNA complement(2834730..2834847) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-5S rRNA" gene complement(2834730..2834847) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /label="rrnB-5S gene" rRNA complement(2834903..2837830) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-23S rRNA" gene complement(2834903..2837830) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /label="rrnB-23S gene" rRNA complement(2837998..2839552) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-16S rRNA" gene complement(2837998..2839552) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /label="rrnB-16S gene" Polymorphism join(2839354,2839356) /Source="geneious" /ID="SNP_BsDelta6_3178443_3178443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="T -> C" /Codon_Change /Coverage=95 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="3.5e-102" /Variant_Raw_Frequency=94 /comment="rrnB-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(2839553..2839844) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2839680..2839688 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2839686 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2839796 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2839817..2839836) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2839844) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2839846..2840812) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2839850..2839857) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2839969..2839972 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2839984 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2839987..2840006 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2840017..2840118 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswC RNA" gene 2840017..2840118 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /label="tswC gene" downshifts 2840117 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" /label="downshifts" CDS 2840218..2840796 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" /label="thiT CDS" gene 2840218..2840796 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /label="thiT gene" downshifts 2840786 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2840838..2841359) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" /label="yuaI CDS" gene complement(2840838..2841359) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /label="yuaI gene" downshifts complement(2840856) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" /label="downshifts" downshifts complement(2840928) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2841377..2842906) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" /label="floT CDS" gene complement(2841377..2842906) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /label="floT gene" CDS complement(2842927..2843451) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" /label="nfeDB CDS" gene complement(2842927..2843451) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /label="nfeDB gene" promotor_-10 complement(2843495..2843510) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2843501) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="upshifts" S_feature complement(2843503..2843590) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2843522..2843531) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2843575..2843593) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2843585 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2843589..2843608 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2843590) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2843608..2843613) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2843619..2844107 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" /label="yuaE CDS" gene 2843619..2844107 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /label="yuaE gene" downshifts 2844084 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" /label="downshifts" CDS complement(2844113..2844691) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" /label="yuaD CDS" gene complement(2844113..2844691) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /label="yuaD gene" S_feature 2844129..2844520 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2844140) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2844725..2844744) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2844734) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2844758..2844765) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2844779..2845987) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" /label="gbsB CDS" gene complement(2844779..2845987) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /label="gbsB gene" downshifts complement(2844800) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2845756..2845775) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2845768) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2845790..2845797) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2846004..2847476) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" /label="gbsA CDS" gene complement(2846004..2847476) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /label="gbsA gene" promotor_-10 complement(2847527..2847546) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2847528) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2847561..2847568) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2847588..2847594 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2847608..2847627 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2847623 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2847675..2848217 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" /label="gbsR CDS" gene 2847675..2848217 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /label="gbsR gene" downshifts 2848200 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2848294..2848301 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2848314..2848414 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2848314 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2848316..2848335 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2848415..2848960 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" /label="bslA CDS" gene 2848415..2848960 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /label="bslA gene" downshifts 2848947 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2849052..2849059 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2849073..2849092 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2849080 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2849085..2849253 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" /label="swdA RNA" gene 2849085..2849253 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /label="swdA gene" downshifts 2849234 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 2849326..2849994 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" /label="ktrA CDS" gene 2849326..2849994 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /label="ktrA gene" CDS 2850001..2851338 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" /label="ktrB CDS" gene 2850001..2851338 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /label="ktrB gene" downshifts 2851324 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2851374..2851637) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" /label="yubF CDS" gene complement(2851374..2851637) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /label="yubF gene" downshifts complement(2851392) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2851677..2851696) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2851679) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2851709..2851716) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2851746..2852594) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" /label="lytG CDS" gene complement(2851746..2852594) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /label="lytG gene" promotor_-10 complement(2852639..2852658) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2852649) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2852673..2852680) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2852755..2854290) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" /label="yubD CDS" gene complement(2852755..2854290) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /label="yubD gene" downshifts complement(2852764) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 2853948..2854048 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2854008 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2854074 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature complement(2854291..2854458) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2854447..2854466) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2854458) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2854460..2855337) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2854481..2854488) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2854700..2854709 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2854723..2854742 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2854723 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="upshifts" CDS 2854775..2855260 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" /label="cdoA CDS" gene 2854775..2855260 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /label="cdoA gene" S_feature 2855261..2855547 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2855367..2855439) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Ala1 tRNA" gene complement(2855367..2855439) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /label="trnSL-Ala1 gene" downshifts complement(2855382) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2855426) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2855450..2855469) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2855470) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2855484..2855487) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2855504 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2855547..2856377) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" /label="uppP CDS" gene complement(2855547..2856377) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /label="uppP gene" downshifts complement(2855558) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2856378..2856469) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2856470..2857636) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" /label="yubA CDS" gene complement(2856470..2857636) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /label="yubA gene" promotor_-35 2857632..2857636 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2857644..2857658 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2857660..2857679) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2857660 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2857679) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2857693..2857700) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2857758..2857765 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2857771 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2857776..2857795 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2857818..2858804 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA*" /label="iolU CDS" gene 2857818..2858804 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /label="iolU gene" downshifts 2858775 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2858845..2860119) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /EC_number="5.3.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose isomerase" /protein_id="NP_390996.1" /db_xref="EnsemblGenomes-Gn:BSU31180" /db_xref="EnsemblGenomes-Tr:CAB15096" /db_xref="GOA:O05264" /db_xref="InterPro:IPR009308" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG12387" /db_xref="UniProtKB/Swiss-Prot:O05264" /translation="MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIE GFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNRE AVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRH CIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQ HNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSML LYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRV AAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCE QMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV*" /label="rhaA CDS" gene complement(2858845..2860119) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /label="rhaA gene" downshifts complement(2858858) /Source="Nicolas_upshifts" /id="D1615" /incds=0 /nref=3 /ntot=29 /MaxReadThrough="0.802" /MaxDrop="4.45322" /score="14.0829844" /energy="-12.6" /TU="NA" /idTUdmin="U2421" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2860145..2860459) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /EC_number="5.1.3.32" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15576793, 15876375, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576793, 15876375, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose mutarotase" /protein_id="NP_390997.1" /db_xref="EnsemblGenomes-Gn:BSU31190" /db_xref="EnsemblGenomes-Tr:CAB15097" /db_xref="GOA:O05263" /db_xref="InterPro:IPR008000" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR013448" /db_xref="SubtiList:BG12386" /db_xref="UniProtKB/Swiss-Prot:O05263" /translation="MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIF LDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFY LD*" /label="rhaM CDS" gene complement(2860145..2860459) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /label="rhaM gene" CDS complement(2860477..2861934) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /EC_number="2.7.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16674975, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16674975, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnulokinase" /protein_id="NP_390998.1" /db_xref="EnsemblGenomes-Gn:BSU31200" /db_xref="EnsemblGenomes-Tr:CAB15098" /db_xref="GOA:O05262" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR013449" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG12385" /db_xref="UniProtKB/Swiss-Prot:O05262" /translation="MIYTAIDVGASSGRIMVGELNEGKLDIQEIHRFANGFSQRDGHC LWDIDHLLKQILQGLQKVKTLGYEHCTVGIDTWAVDYVLLDEKGDRLREAISYRDRRT DHTIDKLEHTLSKAAIYQKTGIQFQPFNTIYQLFEEDRELLKKTDKIMMIPDYLGYCL TGKAVTEITNVSTTQLLNVSTGNLDPELLEAVSVLEQQFAPLTEPGCELGKLRNEWFP DYDLPACKVMTVATHDTASAVIAAPGVNDGWAYISSGTWSLIGVENKTPIITDLALEN NYTNERGANNTIRFLKNIIGMWVIQEVKQQLQADYSFQQLAEEAKKTEPFQQFINLND KRFLNPENMIKEIQHYCRQTRQKIPRTAGELACCIYSNLAIIYAIAIKELETITEKPI EQFHIIGGGARNDFLNQLTADMSGKAVYAGPIEATATGNLLMQMIAAKEVKDIKEARQ VVRNSFPIKVFTPKDIDRSTIIQSFQQTVLKALSK*" /label="rhaB CDS" gene complement(2860477..2861934) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /label="rhaB gene" CDS complement(2861939..2862715) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11496004, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11496004, 26712933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the rhamnose operon(RhaR / l-rhamnulose-1-phosphate)" /protein_id="NP_390999.1" /db_xref="EnsemblGenomes-Gn:BSU31210" /db_xref="EnsemblGenomes-Tr:CAB15099" /db_xref="GOA:O05261" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12384" /db_xref="UniProtKB/Swiss-Prot:O05261" /translation="MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLE KEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDAST TAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSL ETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSH IASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG*" /label="rhaR CDS" gene complement(2861939..2862715) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /label="rhaR gene" misc_feature complement(2862749..2862768) /Source="Nicolas_upshift_promotors" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2862765) /Source="Nicolas_upshifts" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2862772..2864841) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /EC_number="1.1.1.-" /EC_number="4.1.2.19" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24391637, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24391637, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase" /protein_id="NP_391000.1" /db_xref="EnsemblGenomes-Gn:BSU31220" /db_xref="EnsemblGenomes-Tr:CAB15100" /db_xref="GOA:P40747" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR013454" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG10947" /db_xref="UniProtKB/Swiss-Prot:P40747" /translation="MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSM KTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYL SHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVW VPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQY INDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEF VNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQ AYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATAL GQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAE GGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGID IVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGS KNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWR EERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGG VPAAFTR*" /label="rhaE CDS" gene complement(2862772..2864841) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /label="rhaE gene" promotor_-10 complement(2864874..2864893) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2864886) /Source="Nicolas_upshifts" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2864907..2864913) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2864979..2866967) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391001.1" /db_xref="EnsemblGenomes-Gn:BSU31230" /db_xref="EnsemblGenomes-Tr:CAB15101" /db_xref="GOA:P39217" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10862" /db_xref="UniProtKB/Swiss-Prot:P39217" /translation="MGKFIQWIKQPSISKPLIAAFLAVLILPVGVLAYFSYQSAWNAL DRELISSAKGNVEELNSTLQNKLEDKVKAIDYYSETVDKDILLGKNKTLLKEKFKQYT TLNDDVGAIYAASEDKKLYKYPDSGVPKGFDPTGRDWYKQAVAEKGQAVFSEPYTDEA TGDIVVTISKQLKDGSGVIALDLNLDEVLTASKRIKIGKEGFAFITTGNKKYIAHPTI KPGTTGSGDWTNQVYSKKEGSFEYTFEGKEKKMAFTTNKLTGWKIAGTYFVSELQDAS SPVLNTAVIILCVSIVIGGILILYIIRAITKPLRKLVSTSAKISSGDLTEVIDIHSKN EFGQLGESFNEMSASLRSVIGVIQTSVENVASSSEELTASAAQTSKATEHITLAIEQF SDGNEAQSEKLETSSNHLSQMNEGISKVAQASSTITKSSIQSSEAAGSGEKLVEHTVG QMKTIDQSVQKAEAVVKGLETKSQDITSILNVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIQEIVREISTSLSMFQSVNHEVKEGLQITDQ TAESFKQIYEMTTQISGELQNLNATVEQLSAGSQEVSSAVEDISAVAKESSAGIQDIA ASAEEQLASMEEISSSAETLANMAEELQDITKKFKIES*" /label="tlpB CDS" gene complement(2864979..2866967) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /label="tlpB gene" downshifts complement(2864998) /Source="Nicolas_upshifts" /id="D1616" /incds=0 /nref=108 /ntot=174 /MaxReadThrough="3.32915" /MaxDrop="6.75141" /score="18.7221191" /energy="-8.3" /TU="NA" /idTUdmin="U2423" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2866971..2866978 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2866988..2867006) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2866994..2867013 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2867001) /Source="Nicolas_upshifts" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="upshifts" upshifts 2867010 /Source="Nicolas_upshifts" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2867020..2867027) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2867076 /Source="Nicolas_upshifts" /id="D1617" /incds=0 /nref=4 /ntot=11 /MaxReadThrough="1.04089" /MaxDrop="4.2056" /score="13.4355481" /energy="-10.7" /TU="NA" /idTUdmin="U2424" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2867081..2869066) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 9721285, 12011078" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 9721285, 12011078; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391002.2" /db_xref="EnsemblGenomes-Gn:BSU31240" /db_xref="EnsemblGenomes-Tr:CAB15102" /db_xref="GOA:P39214" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10861" /db_xref="UniProtKB/Swiss-Prot:P39214" /translation="MKKILQLIKQRSITRKLLVSFLSILIIPVVILAIFAYQSASSSL DRQMMGSALENVQQLNEIINTSIGEKENSADYFSEWLTKEKYNAKSNASIAEKFSQYI SINKDVESIYTSDTKGHFTRYPDLPMPSGYNPVERDWYKKAVANKGKVVITDPYKTAS TNTMVVTIAQQTKDGSGVIAINMTIENLLKTTKKVNIGTQGYAFIMTKDKKVVAHPNE QSGTELKGDWLDKMLSADKGDFQYTMDGDKKKMAFDTNKLTGWKIGGTMYLDEIHEAA QPVLHLALIVLAAAIIIGIIVMTLIIRSITTPLKQLVGSSKRISEGDLTETIDIRSKD ELGELGKSFNNMASSLRSLIHAIQDSVDNVAASSEELTASAAQTSKATEHITLAIEQF SNGNEKQNENIETAAEHIYQMNDGLTNMAQASEVITDSSVQSTEIASEGGKLVHQTVG QMNVIDKSVKEAEQVVRGLETKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIIEIVKEINTSLGMFQSVNQEVQTGLDITDK TEMSFKRISEMTNQIAGELQNMSATVQQLSASSEEVSGASEHIASISKESSAHIQDIA ASAEEQLASMEEISSSAETLSSMAEELRDMTKRFKIE*" /label="mcpA CDS" gene complement(2867081..2869066) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /label="mcpA gene" downshifts complement(2867086) /Source="Nicolas_upshifts" /id="D1618" /incds=0 /nref=196 /ntot=232 /MaxReadThrough="3.11319" /MaxDrop="7.54297" /score="40.6270404" /energy="-13.6" /TU="U2425" /idTUdmin="U2425" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2869087..2869105) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2869102) /Source="Nicolas_upshifts" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2869104..2869191) /Source="Nicolas_S_feature" /locus_tag="new_3208192_3208279_c" /HighExp="GM 150, T0.0H, T-1.40H, T-0.40H, MG 150, T-5.40H, T-3.40H, T-1.10H, T-2.40H, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1190" promotor_-35 complement(2869119..2869126) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2869192..2871180) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871, 26522943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871, 26522943; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (membrane curvature dependent localisation)" /protein_id="NP_391003.1" /db_xref="EnsemblGenomes-Gn:BSU31250" /db_xref="EnsemblGenomes-Tr:CAB15103" /db_xref="GOA:P39216" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10860" /db_xref="UniProtKB/Swiss-Prot:P39216" /translation="MKKTLTTIRRSSIARRLIISFLLILIVPITALSVSAYQSAVASL DVQMTQSAKENVQILDHIIDDKISTTEKSLAYFSDWATAEKFQDKKKTELKQEFKQFI QMNDNVAAVFSSGKDGDFTRYPYADMPSDFNALERDWYKEAMANKGKTIVTEPYESIS SGKMVVTIARQTVDGSGVVAIDMKIDDLVTTAKGINIGKEGYAFILSQNKKVIAYSGE KAGTELKGDWVDKLYKDKSGDFEYTYKGKKKKMAFATSQTTGWKISGTMYANEIHDAA SRVLIMASIVLAIAIGAGMTAIYFVIRSITKPLRRIVASAEKISEGDLTETIEINSKD ELGVLSESFNHMAHSLRSLIHGIKDSVEHVASSSEELTASADQTSRATEHITMAIEQF SNGSESQSEKIETTTEQINEMNDGLAELARAAAVITETSADSTEVSSKGETLVQKTAG QMNTIDHSVKAAEQVVKGLEIKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIESLISEIVKEIHTSLNVLQSVNKEVETGLVMTDE TKQSFKHISQMTNQIASELQNMNATVEELSAGAQEISAASNDITAISKESSDGIQDIA ASAEEQLASMEEISSSALTLERMSEELRDLTKQFKVDK*" /label="tlpA CDS" gene complement(2869192..2871180) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /label="tlpA gene" promotor_-10 complement(2871205..2871223) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-10" upshifts complement(2871220) /Source="Nicolas_upshifts" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="upshifts" promotor_-35 complement(2871237..2871244) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-35" CDS complement(2871357..2873345) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391004.2" /db_xref="EnsemblGenomes-Gn:BSU31260" /db_xref="EnsemblGenomes-Tr:CAB15104" /db_xref="GOA:P39215" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10859" /db_xref="UniProtKB/Swiss-Prot:P39215" /translation="MKTFINWLKKPSISKKLIVSFIAILIIPILILEFSSYRSASGKL DQEIMGNAKNSVDTFNTTVTNDLGEKAKAVTFFSESLKRSAFKGKSNQEEIKAKFSQY VSINQGVARIYGGADNGTYVQAPKEKLPEGYDPRQRPWYQDAMKAGGEIVVTDPYVAA SDGSMVITIAQELKDGSGVVAMDITIDKLLEQMKQIKVGKEGYAFIATKNKTYVAHKN HKAGEKLSGDWVAKMYANDSGELQYTLNNEDKKMTYTTNELTGWKIAGTMYMDEIKDA SKSVLTTGMIVLIASIVAGGILILFIVRSITKPLKRLVQSSKTISRGDLTETIEIHSK DELGELGESFNEMGQSLRSLISAIQDSVNNVAASSEQLTASAGQTSKATEHITMAIEQ FSNGNEEQSEKVESSSHQLNLMNEGLQQVSQTSSDITKASIQSTEIAGTGEKFVQQTV GQMNSINQSVQQAEAVVKGLEGKSKDITSILRVINGIADQTNLLALNAAIEAARAGES GRGFSVVAEEVRKLAVQSADSAKEIEKLIQEIVAEIDTSLHMFKEVNQEVQSGLVVTD NTKESFQSIFSMTNEIAGKLQTMNSTVEQLSDRSQHVSAAVSGIADVSKESSASIQDI AASAEEQLASMEEISSSATTLAQMAEELRDLTKQFKIE*" /label="mcpB CDS" gene complement(2871357..2873345) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /label="mcpB gene" downshifts complement(2871376) /Source="Nicolas_upshifts" /id="D1619" /incds=0 /nref=136 /ntot=224 /MaxReadThrough="3.76161" /MaxDrop="7.09773" /score="30.8363643" /energy="-10.7" /TU="U2427" /idTUdmin="U2427" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2873366..2873384) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2873387) /Source="Nicolas_upshifts" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2873397..2873404) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2873447..2873456 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2873470..2873489 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2873473 /Source="Nicolas_upshifts" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="upshifts" CDS 2873503..2874240 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /EC_number="2.3.2.13" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9692191, 16267299, 16751597, 16936016, 18249137, 26322858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9692191, 16267299, 16751597, 16936016, 18249137, 26322858; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein-glutamine gamma-glutamyltransferase (transglutaminase)" /protein_id="NP_391005.1" /db_xref="EnsemblGenomes-Gn:BSU31270" /db_xref="EnsemblGenomes-Tr:CAB15105" /db_xref="GOA:P40746" /db_xref="InterPro:IPR020916" /db_xref="PDB:4P8I" /db_xref="PDB:4PA5" /db_xref="SubtiList:BG10946" /db_xref="UniProtKB/Swiss-Prot:P40746" /translation="MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAE LMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAI RDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTET GHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFR KKGALQSAYLLSQATRLDVPSLFRIVR*" /label="tgl CDS" gene 2873503..2874240 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /label="tgl gene" promotor_-10 complement(2873528..2873547) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-10" upshifts complement(2873536) /Source="Nicolas_upshifts" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="upshifts" promotor_-35 complement(2873563..2873567) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-35" S_feature 2874241..2877061 /Source="Nicolas_S_feature" /locus_tag="new_3213329_3216149" /HighExp="S6, S8, S7, BT, S5, C30, B36, Pyr, BC, C90" /AntisenseName="yugT" /AntisenseCor="0.63350809138227804" /AntisenseRegPval="-30.9" /CDS_PredictionProba="0.61985900000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1191" CDS complement(2874254..2874508) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097776.1" /db_xref="EnsemblGenomes-Gn:BSU31279" /db_xref="EnsemblGenomes-Tr:CAX52682" /db_xref="UniProtKB/Swiss-Prot:C0H3Q3" /translation="MNILQYSYKKRGKIEFVFEGWPHSKVTMVPIKGYYFVRFIKWSS QDPIVTRNDLEKMEWAANQYFGTAPFYRKRKAFETPSSGK*" /label="yuzH CDS" gene complement(2874254..2874508) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /label="yuzH gene" downshifts complement(2874280) /Source="Nicolas_upshifts" /id="D1620" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="2.39206" /MaxDrop="2.92958" /score="-2.51333596" /energy="-14.7" /TU="NA" /idTUdmin="U2430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2874509..2874765) /Source="Nicolas_S_feature" /locus_tag="new_3213597_3213853_c" /HighExp="Etha, Sw, Salt, Gly, BC, M9-stat, Lbstat, Heat, LPhT, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37980700000000001" /TUshortSig="SigB" /TUshortPSig="0.969" /TUlongSig="NA" /TUlongPSig="NA" /label="S1192" CDS complement(2874766..2875164) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391006.2" /db_xref="EnsemblGenomes-Gn:BSU31280" /db_xref="EnsemblGenomes-Tr:CAB15106" /db_xref="InterPro:IPR001602" /db_xref="InterPro:IPR035917" /db_xref="SubtiList:BG12373" /db_xref="UniProtKB/Swiss-Prot:O05243" /translation="MLKTLQIKTTKRDEMIDITREVEAFLQETGITSGAALIYCPHTT AGITINENADPDVKKDMLRRFDEVYPWEHELDRHMEGNTAAHMKSSTVGASQHVIVEN GRLILGTWQGIYFCEFDGPRTRTCYIKMMG*" /label="yugU CDS" gene complement(2874766..2875164) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /label="yugU gene" CDS complement(2875124..2875258) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514000.1" /translation="MFYRVYESGLTGKKRTQNELSDESGQTKGETNAENTANQNNQTR *" /label="hypothetical protein CDS" gene complement(2875124..2875258) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /label="gene" promotor_-10 complement(2875207..2875226) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2875214) /Source="Nicolas_upshifts" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2875241..2875247) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2875284..2876948) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1761534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-1,6-glucosidase" /protein_id="NP_391007.2" /db_xref="EnsemblGenomes-Gn:BSU31290" /db_xref="EnsemblGenomes-Tr:CAB15118" /db_xref="GOA:O05242" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG12372" /db_xref="UniProtKB/Swiss-Prot:O05242" /translation="MKKAWWKEAVVYQIYPRSFKDSNGDGIGDIQGIRTKLSYIKELG ADVIWICPLYDSPNADNGYDIRDYQNILSEFGTMEDFDELLGDIHDLDMKLIMDLVVN HTSDEHPWFIESRSSIHSEKRDWYIWKDGKNGKTPNNWESIFGGPAWEYDQKTSQYYL HLFDKKQPDLNWENEKVRNAVYDMINWWLDKGIDGFRVDAITHIKKKEGFPDMPNPKG LDYVPSFPYHMNADGIMDLLTELKENTFSRYPIMTVGEANGVAAKEAADWAGEKNGIF SMIFQFEHLGLWDVEINESIDIVAFKRILTDWQDSLEGIGWNALFMENHDQPRSVSVW GDDGVYLKESAKALSAVYFLMKGTPFIYQGQELGMTNVAFPSIEDYDDVALKRLYETK TAKGTSHEDVMKIVWKKGRDNSRTPMQWNAGPYAGFSEAKPWIGINENYKWLNAEAQK NDKTSVYHFYKSLIKLRQTYDVFINGTYELILPEDQQIFAYLRKNESHTALIAANLTG TPALFRHSGLPLSSDALVLSNIETEPHKHMTSVLLKPYEARIYLWC*" /label="yugT CDS" gene complement(2875284..2876948) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /label="yugT gene" downshifts complement(2875300) /Source="Nicolas_upshifts" /id="D1621" /incds=0 /nref=13 /ntot=38 /MaxReadThrough="1.79723" /MaxDrop="4.64379" /score="19.4176812" /energy="-6.5" /TU="NA" /idTUdmin="U2432" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2876256..2876275) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2876261) /Source="Nicolas_upshifts" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2876289..2876296) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2876973..2876991) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2876990) /Source="Nicolas_upshifts" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2877007..2877012) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2877075..2878364) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_391008.2" /db_xref="EnsemblGenomes-Gn:BSU31300" /db_xref="EnsemblGenomes-Tr:CAB15119" /db_xref="GOA:O05241" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12371" /db_xref="UniProtKB/Swiss-Prot:O05241" /translation="MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSR ALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIV TFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSA SFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVARE IMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLG QPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEI VGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQ KMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF*" /label="yugS CDS" gene complement(2877075..2878364) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /label="yugS gene" downshifts complement(2877084) /Source="Nicolas_upshifts" /id="D1622" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.89237" /MaxDrop="3.67001" /score="3.60520478" /energy="-7.6" /TU="NA" /idTUdmin="U2434" /TUdmin=13 /isTUend="TRUE" /label="downshifts" promotor_-35 2877893..2877899 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2877913..2877931 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2877919 /Source="Nicolas_upshifts" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="upshifts" S_feature 2877923..2878575 /Source="Nicolas_S_feature" /locus_tag="new_3217011_3217663" /HighExp="Etha, Sw, Gly, Salt, BC, B60, Heat, S8, B36, HiTm" /AntisenseName="yugS" /AntisenseCor="0.12310225183111501" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1193" CDS complement(2878408..2879085) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16704729, 16850406, 24383880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent protease/peptidase" /protein_id="NP_391009.1" /db_xref="EnsemblGenomes-Gn:BSU31310" /db_xref="EnsemblGenomes-Tr:CAB15120" /db_xref="GOA:O05248" /db_xref="InterPro:IPR007395" /db_xref="SubtiList:BG12370" /db_xref="UniProtKB/Swiss-Prot:O05248" /translation="MLFIFLTIAALGLSFWAQFKVKSNFEKYSKVEASSGRTGAETAR RILDINGLYDVPVEPVRGTLTDHYDPTRRVVRLSEPVYYGRSISAISVASHEVGHALQ HQESYGALVLRHKIFPVVNFASGVAPLLFLGGMLLGSLNLIGLGIILFSAAVFFQLIT LPVEFNASSRAKQIIVSEGFIRNNEENGVNKVLSAAALTYVAAALVSLFELLRFVMIF LNGRDEN*" /label="yugP CDS" gene complement(2878408..2879085) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /label="yugP gene" downshifts complement(2878418) /Source="Nicolas_upshifts" /id="D1623" /incds=0 /nref=153 /ntot=249 /MaxReadThrough="3.51629" /MaxDrop="4.854" /score="33.0420688" /energy="-13" /TU="U2434,U2435" /idTUdmin="U2435" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" S_feature 2878760..2879436 /Source="Nicolas_S_feature" /locus_tag="new_3217848_3218524" /HighExp="Sw, S8, Salt, BC, S7, Etha, Gly, B36, B60, LPhT" /AntisenseName="yuzI" /AntisenseCor="0.20035821815170399" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1194" promotor_-10 complement(2879120..2879139) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2879127..2879390) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16704729; Product type f : factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097777.1" /db_xref="EnsemblGenomes-Gn:BSU31319" /db_xref="EnsemblGenomes-Tr:CAX52683" /db_xref="GOA:C0H3Q4" /db_xref="UniProtKB/Swiss-Prot:C0H3Q4" /translation="MTIFQRTIVVLIGTQLAASAVILFIFDLNSYNHFSGSFSWLHFL KELAGSFAFYLFSAGLFFLLIGLCAPSRKKKRISVHEKENSLK*" /label="yuzI CDS" gene complement(2879127..2879390) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /label="yuzI gene" upshifts complement(2879141) /Source="Nicolas_upshifts" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2879153..2879160) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2879402..2879420) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2879416) /Source="Nicolas_upshifts" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2879436..2879441) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2879437..2879769 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15731457, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15731457, 23737939, 25297828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="atypical membrane-integrating regulator of biofilm formation (Mistic protein)" /protein_id="YP_003097778.1" /db_xref="EnsemblGenomes-Gn:BSU31321" /db_xref="EnsemblGenomes-Tr:CAX52684" /db_xref="GOA:Q5BU39" /db_xref="InterPro:IPR021078" /db_xref="PDB:1YGM" /db_xref="UniProtKB/Swiss-Prot:Q5BU39" /translation="MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRM NEGLDAFIQLYNESEIDEPLIQLDDDTAELMKQARDMYGQEKLNEKLNTIIKQILSIS VSEEGEKE*" /label="mstX CDS" gene 2879437..2879769 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /label="mstX gene" promotor_-35 2879454..2879460 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2879475..2879492 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2879486 /Source="Nicolas_upshifts" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="upshifts" CDS 2879766..2880752 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16704729, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16704729, 23737939, 25297828; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium channel protein involved in biofilm formation" /protein_id="NP_391010.3" /db_xref="EnsemblGenomes-Gn:BSU31322" /db_xref="EnsemblGenomes-Tr:CAB15121" /db_xref="GOA:Q795M8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR013099" /db_xref="InterPro:IPR028325" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12369" /db_xref="UniProtKB/Swiss-Prot:Q795M8" /translation="MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTS VFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQH RYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHF IRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVE ILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLA VPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI*" /label="kbfO CDS" gene 2879766..2880752 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /label="kbfO gene" downshifts complement(2880727) /Source="Nicolas_upshifts" /id="D1624" /incds=0 /nref=44 /ntot=128 /MaxReadThrough="0.617940000000001" /MaxDrop="4.76695" /score="21.5904825" /energy="-11.3" /TU="NA" /idTUdmin="U2437" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2880749..2881153) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391011.1" /db_xref="EnsemblGenomes-Gn:BSU31330" /db_xref="EnsemblGenomes-Tr:CAB15122" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG12368" /db_xref="UniProtKB/Swiss-Prot:O05246" /translation="MIPIPSAIDGQSFLLQELEQVMKPLGYVINGGWEYDHGYFDYKI DDRDGYLFLRIPVNAVQGSLDERGAAVRIGTPFMLRQVFQADVDDHAEGGPFQSLFNQ FSEPERRDAEIDPAFLDIGASLVKELEDVLLH*" /label="yugN CDS" gene complement(2880749..2881153) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /label="yugN gene" S_feature complement(2881154..2881212) /Source="Nicolas_S_feature" /locus_tag="new_3220242_3220300_c" /HighExp="M0t90, M40t90, S6, S8, S7, T0.30H, Lbstat, M9-stat, T1.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-, SigA" /TUshortPSig="0.686, 0.141, 0.984" /TUlongSig="SigA" /TUlongPSig="0.988" /label="S1195" CDS complement(2881213..2881584) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391012.1" /db_xref="EnsemblGenomes-Gn:BSU31340" /db_xref="EnsemblGenomes-Tr:CAB15123" /db_xref="GOA:O05245" /db_xref="SubtiList:BG12367" /db_xref="UniProtKB/Swiss-Prot:O05245" /translation="MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHF FIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAV YFLIECAFFPVGRAKETTISM*" /label="yugM CDS" gene complement(2881213..2881584) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /label="yugM gene" CDS complement(2881643..2882995) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" /label="pgi CDS" gene complement(2881643..2882995) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /label="pgi gene" downshifts complement(2881654) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2881810..2881828) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2881827) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2881844..2881849) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2882968) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2882971..2882982) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2883027..2883046) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2883033) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2883035..2883106) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2883061..2883064) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2883107..2884279) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" /label="bdhK CDS" gene complement(2883107..2884279) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /label="bdhK gene" S_feature 2883442..2884363 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2884312..2884331) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2884325) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="upshifts" promotor_-35 complement(2884348..2884351) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2884383..2885546) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" /label="bdhJ CDS" gene complement(2884383..2885546) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /label="bdhJ gene" downshifts complement(2884398) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2885561..2885580) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2885579) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="upshifts" S_feature complement(2885581..2885736) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2885595..2885602) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2885632..2885638 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2885653..2885671 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2885663 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2885664..2885722 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2885709..2885715 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2885711..2885722) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2885724 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2885729..2885740 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2885736..2885742) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2885736) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2885738..2886049) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2885776..2886012 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" /label="yuzA CDS" gene 2885776..2886012 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /label="yuzA gene" downshifts 2885972 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2886038 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2886090..2886482) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" /label="yugI CDS" gene complement(2886090..2886482) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /label="yugI gene" downshifts complement(2886094) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2886524..2886543) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2886531) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="upshifts" S_feature complement(2886533..2886683) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2886559..2886563) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2886586..2886592 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2886599..2887583 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2886599 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2886607..2886625 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2886684..2887844) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" /label="yugH CDS" gene complement(2886684..2887844) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /label="yugH gene" promotor_-35 2887736..2887742 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2887754 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2887756..2887760 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2887845..2888345) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" /label="yugG CDS" gene complement(2887845..2888345) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /label="yugG gene" promotor_-10 complement(2888375..2888394) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2888381..2888387 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2888396) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="upshifts" promotor_-10 2888402..2888413 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2888402 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2888405..2888412) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2888414..2888492 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2888493..2889314 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" /label="yugF CDS" gene 2888493..2889314 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /label="yugF gene" downshifts 2889294 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2889341) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(2889343..2889603) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" /label="yugE CDS" gene complement(2889343..2889603) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /label="yugE gene" promotor_-35 2889593..2889596 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2889611..2889630 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2889623 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="upshifts" S_feature 2889624..2889689 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2889629..2889648) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2889634) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2889660..2889666) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2889690..2890853 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" /label="patB CDS" gene 2889690..2890853 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /label="patB gene" promotor_-35 2890916..2890922 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2890934..2890953 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2890944 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2890979..2892265 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" /label="kinB CDS" gene 2890979..2892265 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /label="kinB gene" S_feature complement(2891981..2892723) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2892260..2892267 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2892281..2892300 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2892282 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2892311..2892697 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" /label="kapB CDS" gene 2892311..2892697 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /label="kapB gene" downshifts 2892679 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2892724..2893341) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" /label="kapD CDS" gene complement(2892724..2893341) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /label="kapD gene" promotor_-10 complement(2893376..2893394) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2893393) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2893395..2895483) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(2893409..2893414) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2893457..2893460 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 2893475..2893494 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 2893486 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="upshifts" CDS 2893552..2894730 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" /label="yuxJ CDS" gene 2893552..2894730 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /label="yuxJ gene" promotor_-35 2894768..2894774 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2894786..2894805 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2894791 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="upshifts" CDS 2894823..2896697 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" /label="pbpD CDS" gene 2894823..2896697 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /label="pbpD gene" promotor_-10 complement(2895463..2895482) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2895483) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2895496..2895505) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2896718..2897131 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" /label="yuxK CDS" gene 2896718..2897131 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /label="yuxK gene" downshifts 2897123 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2897334..2897891) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" /label="yufK CDS" gene complement(2897334..2897891) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /label="yufK gene" misc_feature 2897355..2897374 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2897365 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2897375) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 2897387..2898068 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(2897917..2897936) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2897925) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2897952..2897956) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2898069..2899670 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" /label="maeL CDS" gene 2898069..2899670 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /label="maeL gene" CDS 2899663..2900370 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" /label="maeM CDS" gene 2899663..2900370 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /label="maeM gene" downshifts 2900355 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" /label="downshifts" promotor_-35 2900534..2900541 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2900552..2900841 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 2900552 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2900556..2900575 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2900842..2901921 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" /label="nupN CDS" gene 2900842..2901921 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /label="nupN gene" CDS 2901997..2903529 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" /label="nupO CDS" gene 2901997..2903529 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /label="nupO gene" CDS 2903522..2904568 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" /label="nupP CDS" gene 2903522..2904568 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /label="nupP gene" CDS 2904569..2905528 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" /label="nupQ CDS" gene 2904569..2905528 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /label="nupQ gene" S_feature 2905529..2905650 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 2905623..2905626 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2905641..2905660 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2905652 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="upshifts" CDS 2905682..2907028 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" /label="maeN CDS" gene 2905682..2907028 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /label="maeN gene" downshifts 2907011 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(2907064..2907279) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" /label="yufS CDS" gene complement(2907064..2907279) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /label="yufS gene" promotor_-35 2907219..2907225 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2907239..2907250 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2907243 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2907290..2907308) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2907297) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2907322..2907329 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2907324..2907329) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2907344..2907439 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 2907344..2907363 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2907344 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2907402..2907406 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2907422..2907441 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2907441..2907590 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 2907441 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2907510..2909915 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" /label="mrpA CDS" gene 2907510..2909915 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /label="mrpA gene" CDS 2909908..2910339 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" /label="mrpB CDS" gene 2909908..2910339 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /label="mrpB gene" CDS 2910339..2910680 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" /label="mrpC CDS" gene 2910339..2910680 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /label="mrpC gene" promotor_no_box 2910571..2910671 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2910631 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2910673..2912154 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" /label="mrpD CDS" gene 2910673..2912154 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /label="mrpD gene" S_feature complement(2911406..2913274) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 2912160..2912636 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" /label="mrpE CDS" gene 2912160..2912636 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /label="mrpE gene" CDS 2912636..2912920 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" /label="mrpF CDS" gene 2912636..2912920 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /label="mrpF gene" CDS 2912904..2913278 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" /label="mrpG CDS" gene 2912904..2913278 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /label="mrpG gene" downshifts 2913249 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2913317..2913697) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" /label="yuxO CDS" gene complement(2913317..2913697) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /label="yuxO gene" downshifts complement(2913319) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" /label="downshifts" CDS complement(2913716..2914360) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" /label="comA CDS" gene complement(2913716..2914360) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /label="comA gene" S_feature complement(2914361..2914440) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(2914441..2916750) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" /label="comP CDS" gene complement(2914441..2916750) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /label="comP gene" promotor_-35 2915435..2915442 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2915456..2915475 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2915471 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 2916344..2917315 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 2916344 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2916356..2916372 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2916765..2916932) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" /label="comX CDS" gene complement(2916765..2916932) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /label="comX gene" CDS complement(2916920..2917818) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKS**RNAY*VIQRGIQDARP" /label="comQ CDS" gene complement(2916920..2917818) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /label="comQ gene" S_feature complement(2917819..2917932) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(2917926..2917945) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2917932) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2917959..2917965) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2918003..2918143) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" /label="degQ CDS" gene complement(2918003..2918143) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /label="degQ gene" downshifts complement(2918032) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2918144..2918230) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(2918214..2918233) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2918230) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2918247..2918253) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2918330..2918348) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2918340) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2918363..2918369) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2918365..2918490 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" /label="hypothetical protein CDS" gene 2918365..2918490 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /label="gene" S_feature complement(2918518..2918947) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 2918543..2918548 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2918560) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 2918563..2918581 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2918565 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="upshifts" CDS 2918604..2918972 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" /label="cotIC CDS" gene 2918604..2918972 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /label="cotIC gene" CDS complement(2918948..2920177) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" /label="pdeH CDS" gene complement(2918948..2920177) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /label="pdeH gene" S_feature 2918973..2920286 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(2920212..2920231) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2920231) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="upshifts" downshifts 2920244 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2920246..2920253) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2920314..2921786) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" /label="pncB CDS" gene complement(2920314..2921786) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /label="pncB gene" downshifts complement(2920324) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" misc_feature 2921667..2921671 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2921674 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2921784 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS complement(2921802..2922353) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" /label="pncA CDS" gene complement(2921802..2922353) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /label="pncA gene" promotor_-10 complement(2922375..2922394) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2922388) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2922407..2922414) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2922450..2922848) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" /label="yueI CDS" gene complement(2922450..2922848) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /label="yueI gene" S_feature complement(2922849..2922919) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(2922920..2923168) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" /label="yueH CDS" gene complement(2922920..2923168) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /label="yueH gene" promotor_-10 complement(2923191..2923210) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2923202) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2923226..2923229) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2923241..2923462) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" /label="yueG CDS" gene complement(2923241..2923462) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /label="yueG gene" downshifts complement(2923268) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2923456 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2923480..2923499) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2923486) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2923512..2923521) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2923522..2924631) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" /label="yueF CDS" gene complement(2923522..2924631) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /label="yueF gene" promotor_-35 2924283..2924290 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2924305..2924324 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2924314..2924708 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 2924314 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2924679..2924698) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(2924695) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="upshifts" S_feature complement(2924697..2925137) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 2924700..2924702 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2924710 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2924712..2924717) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 2924718..2924737 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2924746..2925135 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" /label="yuzE CDS" gene 2924746..2925135 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /label="yuzE gene" CDS complement(2925176..2925412) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" /label="yuzF CDS" gene complement(2925176..2925412) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /label="yuzF gene" downshifts complement(2925182) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2925432..2925451) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2925446) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2925448..2925588) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(2925465..2925474) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2925589..2926119) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" /label="yueE CDS" gene complement(2925589..2926119) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /label="yueE gene" promotor_-10 complement(2926139..2926158) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(2926150) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="upshifts" S_feature complement(2926152..2926238) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(2926170..2926178) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(2926233..2926252) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2926240) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2926266..2926275) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2926317..2927048) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" /label="bznD CDS" gene complement(2926317..2927048) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /label="bznD gene" downshifts complement(2926347) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2927063..2927082) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2927074) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2927097..2927104) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2927111..2927566) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" /label="yueC CDS" gene complement(2927111..2927566) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /label="yueC gene" promotor_-35 2927519..2927525 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2927540..2927558 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2927548..2929915 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 2927548 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2927598..2930828) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" /label="yueB CDS" gene complement(2927598..2930828) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /label="yueB gene" CDS complement(2930825..2935312) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" /label="yukAB CDS" gene complement(2930825..2935312) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /label="yukAB gene" promotor_-35 2934587..2934593 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2934608..2934626 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2934614..2935576 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 2934614 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2935373..2936728) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" /label="yukC CDS" gene complement(2935373..2936728) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /label="yukC gene" downshifts complement(2935394) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" /label="downshifts" CDS complement(2936743..2936982) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" /label="yukD CDS" gene complement(2936743..2936982) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /label="yukD gene" CDS complement(2937052..2937345) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" /label="yukE CDS" gene complement(2937052..2937345) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /label="yukE gene" downshifts complement(2937062) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" /label="downshifts" downshifts 2937339 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" S_feature complement(2937346..2937424) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 2937387..2937394 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2937404..2937423) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2937405 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2937409..2937426 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2937424) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2937438..2937445) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2937483..2937488 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2937503..2937522 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2937515..2937621 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 2937515 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2937690..2937696 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2937710..2937729 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2937713 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2937818..2937821 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 2937830 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="upshifts" promotor_-10 complement(2937833..2937852) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2937837..2937856 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(2937855) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2937866..2939134 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" /label="adeR CDS" gene 2937866..2939134 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /label="adeR gene" promotor_-35 complement(2937867..2937874) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2939194..2939213 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2939199 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2939236..2940372 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" /label="ald CDS" gene 2939236..2940372 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /label="ald gene" downshifts 2940372 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" /label="downshifts" promotor_-35 2940421..2940429 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2940439 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2940441..2940459 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2940484..2941161 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" /label="yukJ CDS" gene 2940484..2941161 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /label="yukJ gene" downshifts 2941145 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2941205..2941414) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" /label="mbtH CDS" gene complement(2941205..2941414) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /label="mbtH gene" downshifts complement(2941217) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2941430..2948566) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" /label="dhbF CDS" gene complement(2941430..2948566) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /label="dhbF gene" CDS complement(2948586..2949524) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" /label="dhbB CDS" gene complement(2948586..2949524) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /label="dhbB gene" CDS complement(2949552..2951171) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" /label="dhbE CDS" gene complement(2949552..2951171) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /label="dhbE gene" CDS complement(2951200..2952396) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" /label="dhbC CDS" gene complement(2951200..2952396) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /label="dhbC gene" promotor_-35 2952244..2952251 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2952266..2952285 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2952273 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2952422..2953207) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" /label="dhbA CDS" gene complement(2952422..2953207) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /label="dhbA gene" S_feature complement(2953208..2953317) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(2953312..2953331) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2953317) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2953319..2953400) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(2953345..2953352) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2953401..2954270) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" /label="besA CDS" gene complement(2953401..2954270) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /label="besA gene" S_feature complement(2954271..2954351) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(2954335..2954354) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2954351) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2954368..2954375) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2954484..2955080) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" /label="yuiH CDS" gene complement(2954484..2955080) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /label="yuiH gene" S_feature complement(2955081..2955165) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 2955116..2955123 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2955133 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2955138..2955157 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2955159..2955173) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2955165) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2955181..2955185) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2955181..2955783 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" /label="bioYB CDS" gene 2955181..2955783 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /label="bioYB gene" downshifts 2955769 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS complement(2955853..2957181) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" /label="hisP CDS" gene complement(2955853..2957181) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /label="hisP gene" downshifts complement(2955869) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2957235..2957254) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2957238) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2957269..2957276) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2957328..2958830) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" /label="pepA CDS" gene complement(2957328..2958830) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /label="pepA gene" downshifts complement(2957343) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2958395..2958409 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2958411 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2958831..2958905) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 2958853..2958860 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2958871..2958890 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2958873..2958987 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 2958873 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2958900..2958919) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2958910) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="upshifts" CDS 2958988..2959464 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" /label="yuiD CDS" gene 2958988..2959464 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /label="yuiD gene" downshifts 2959413 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" /label="downshifts" CDS complement(2959495..2960151) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" /label="spsC CDS" gene complement(2959495..2960151) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /label="spsC gene" downshifts complement(2959523) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2959799..2959808 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2959822..2959841 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2959839 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="upshifts" S_feature 2959841..2960287 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(2960165) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2960167..2960178) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2960193..2960199) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2960244 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" /label="downshifts" CDS complement(2960255..2960575) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" /label="yuiB CDS" gene complement(2960255..2960575) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /label="yuiB gene" downshifts complement(2960269) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" /label="downshifts" S_feature 2960289..2960499 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 2960441..2960541 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2960501..2960610 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 2960501 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="upshifts" downshifts 2960567 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2960594..2960613) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2960599) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" S_feature 2960612..2961163 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(2960628..2960635) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2960629..2960772) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" /label="yuiA CDS" gene complement(2960629..2960772) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /label="yuiA gene" promotor_-10 complement(2960796..2960815) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2960817) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2960831..2960834) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2960945..2962165) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" /label="yumB CDS" gene complement(2960945..2962165) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /label="yumB gene" downshifts complement(2960973) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2962166..2962293) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(2962293) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2962295..2962359) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(2962295..2962313) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2962329..2962334) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2962350..2962369) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2962358) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2962384..2962391) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2962433..2962440 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2962452..2962471 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2962452 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="upshifts" CDS 2962497..2963495 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" /label="trxBB CDS" gene 2962497..2963495 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /label="trxBB gene" promotor_-10 complement(2962520..2962538) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2962535) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2962555..2962560) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2963471 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2963534..2963674) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" /label="yuzG CDS" gene complement(2963534..2963674) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /label="yuzG gene" downshifts complement(2963546) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2963675..2963804) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(2963785..2963804) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2963804) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2963806..2964053) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(2963818..2963824) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2963861..2963868 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2963882..2963901 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2963890 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2963953..2964933 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" /label="guaC CDS" gene 2963953..2964933 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /label="guaC gene" upshifts complement(2964054) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2964058..2964069) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2964083..2964089) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2964901 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2965006) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2965007..2965630) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" /label="paiB CDS" gene complement(2965007..2965630) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /label="paiB gene" CDS complement(2965654..2966172) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" /label="paiA CDS" gene complement(2965654..2966172) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /label="paiA gene" misc_feature complement(2966219..2966238) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2966231) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2966233..2966341) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(2966328..2966345) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2966339) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2966360..2966367) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2966495) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2966510..2966872) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" /label="sufA CDS" gene complement(2966510..2966872) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /label="sufA gene" promotor_-10 complement(2966903..2966922) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2966913) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2966936..2966943) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2966951..2967805) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" /label="dapF CDS" gene complement(2966951..2967805) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /label="dapF gene" promotor_-10 complement(2967521..2967540) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2967529) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2967553..2967562) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2967827..2967846) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2967841) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2967861..2967864) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2967928..2969142) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" /label="yutK CDS" gene complement(2967928..2969142) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /label="yutK gene" promotor_-35 2968477..2968483 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2968498..2968516 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2968505 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="upshifts" S_feature 2968509..2969278 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(2969179..2969198) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(2969184) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="upshifts" promotor_-35 complement(2969213..2969220) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 2969235 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" /label="downshifts" CDS complement(2969279..2969515) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" /label="yuzB CDS" gene complement(2969279..2969515) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /label="yuzB gene" S_feature 2969280..2969696 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(2969297) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2969480..2969481) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2969485..2969489) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2969487) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2969530..2969549) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2969531) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2969563..2969570) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2969673..2969678 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2969692..2969711 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2969698 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="upshifts" CDS 2969778..2970845 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" /label="yutJ CDS" gene 2969778..2970845 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /label="yutJ gene" downshifts 2970829 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" /label="downshifts" CDS complement(2970871..2971197) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" /label="yuzD CDS" gene complement(2970871..2971197) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /label="yuzD gene" downshifts complement(2970894) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2971229..2971248) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2971246) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2971261..2971268) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2971281..2971285 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2971297..2971632 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" /label="yutI CDS" gene 2971297..2971632 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /label="yutI gene" promotor_-10 2971298..2971317 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2971303 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2971422) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2971610 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2971674..2973647) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" /label="yuxL CDS" gene complement(2971674..2973647) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /label="yuxL gene" downshifts complement(2971686) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2973662..2973680) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2973685) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2973692..2973700) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2973755..2974684) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" /label="thrB CDS" gene complement(2973755..2974684) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /label="thrB gene" downshifts complement(2973768) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2974681..2975739) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" /label="thrC CDS" gene complement(2974681..2975739) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /label="thrC gene" CDS complement(2975739..2977040) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" /label="hom CDS" gene complement(2975739..2977040) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /label="hom gene" promotor_-35 2976925..2976934 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2976949..2976968 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2976956 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2977041..2977122) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(2977107..2977126) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2977122) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2977124..2977240) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(2977141..2977148) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2977241..2978260) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" /label="cotNH CDS" gene complement(2977241..2978260) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /label="cotNH gene" promotor_-35 2978068..2978073 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2978089..2978107 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2978093 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2978283..2978301) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2978290) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2978299..2978304 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2978317..2978322) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2978320..2978384 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 2978320..2978338 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2978320 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2978357..2978366 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2978379..2978398 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2978386 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="upshifts" CDS 2978413..2978913 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" /label="yutG CDS" gene 2978413..2978913 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /label="yutG gene" CDS complement(2978940..2979710) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" /label="nucF CDS" gene complement(2978940..2979710) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /label="nucF gene" downshifts complement(2978968) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2979739..2980173) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" /label="yutE CDS" gene complement(2979739..2980173) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /label="yutE gene" CDS complement(2980197..2980472) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" /label="yutD CDS" gene complement(2980197..2980472) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /label="yutD gene" promotor_-10 complement(2980492..2980511) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2980517) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2980519..2981211) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(2980525..2980532) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2980535..2980541 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2980556..2980567 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2980564 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="upshifts" CDS 2980587..2981219 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" /label="yutC CDS" gene 2980587..2981219 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /label="yutC gene" downshifts 2981180 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2981235..2982131) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" /label="lipA CDS" gene complement(2981235..2982131) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /label="lipA gene" downshifts complement(2981256) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(2982132..2982266) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(2982253..2982272) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(2982266) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="upshifts" promotor_-35 complement(2982288..2982292) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 2982306..2982312 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2982326..2982337 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2982338 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="upshifts" CDS 2982366..2983346 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" /label="lytH CDS" gene 2982366..2983346 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /label="lytH gene" upshifts complement(2982444) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2982458..2982477) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2982494..2982497) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2983338 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2983374..2984138) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" /label="fisB CDS" gene complement(2983374..2984138) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /label="fisB gene" downshifts complement(2983390) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2984152..2984170) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2984160) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2984186..2984191) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2984211..2984516) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " /label="yunC CDS" gene complement(2984211..2984516) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /label="yunC gene" downshifts complement(2984219) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2984530..2984549) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2984553) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2984563..2984571) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2984581..2985969) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" /label="yunD CDS" gene complement(2984581..2985969) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /label="yunD gene" CDS complement(2985989..2986810) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" /label="yunE CDS" gene complement(2985989..2986810) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /label="yunE gene" CDS complement(2986828..2987676) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" /label="yunF CDS" gene complement(2986828..2987676) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /label="yunF gene" promotor_-35 2987195..2987200 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2987216..2987234 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2987230 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2987687..2987706) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2987702) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2987714..2988061) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" /label="yunG CDS" gene complement(2987714..2988061) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /label="yunG gene" promotor_-10 complement(2988074..2988093) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2988093) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2988107..2988113) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2988158..2989498) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" /label="pucH CDS" gene complement(2988158..2989498) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /label="pucH gene" downshifts complement(2988186) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" /label="downshifts" downshifts complement(2989242) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" /label="downshifts" promotor_-35 2989555..2989561 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2989575..2989594 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2989577..2989595) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2989583 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2989584..2989672 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(2989594) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2989611..2989616) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2989673..2991268 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" /label="pucR CDS" gene 2989673..2991268 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /label="pucR gene" CDS 2991413..2992762 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " /label="pucJ CDS" gene 2991413..2992762 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /label="pucJ gene" CDS 2992768..2994060 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" /label="pucK CDS" gene 2992768..2994060 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /label="pucK gene" CDS 2994073..2995557 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" /label="pucL CDS" gene 2994073..2995557 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /label="pucL gene" CDS 2995557..2995901 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" /label="pucM CDS" gene 2995557..2995901 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /label="pucM gene" promotor_-35 2995623..2995626 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2995644..2995663 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2995656 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2995876 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2995917..2996304) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 2996264..2996273 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2996286..2996305 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2996289 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="upshifts" ncRNA complement(2996325..2996456) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" /label="auzJ ncRNA" CDS 2996325..2996456 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " /label="yuzJ CDS" gene 2996325..2996456 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /label="yuzJ gene" gene complement(2996325..2996456) /gene="auzJ" /locus_tag="BSU_ncRNA_2" /label="auzJ gene" S_feature 2996457..2996525 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 2996492 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2996662..2997183) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" /label="pucE CDS" gene complement(2996662..2997183) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /label="pucE gene" CDS complement(2997174..2999411) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" /label="pucD CDS" gene complement(2997174..2999411) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /label="pucD gene" CDS complement(2999412..3000245) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" /label="pucC CDS" gene complement(2999412..3000245) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /label="pucC gene" CDS complement(3000242..3000859) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" /label="pucB CDS" gene complement(3000242..3000859) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /label="pucB gene" downshifts complement(3000351) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" /label="downshifts" CDS complement(3000856..3001848) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" /label="pucA CDS" gene complement(3000856..3001848) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /label="pucA gene" S_feature complement(3001849..3001935) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(3001913..3001932) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3001935) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3001946..3001951) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3002077..3003327) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" /label="pucG CDS" gene complement(3002077..3003327) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /label="pucG gene" CDS complement(3003344..3004582) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" /label="pucF CDS" gene complement(3003344..3004582) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /label="pucF gene" CDS 3004805..3004942 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" /label="hypothetical protein CDS" gene 3004805..3004942 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /label="gene" promotor_-35 3004964..3004967 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3004982..3005001 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3004983 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="upshifts" CDS 3005024..3005890 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" /label="bsnA CDS" gene 3005024..3005890 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /label="bsnA gene" downshifts 3005893 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(3005924..3007027) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" /label="frlP CDS" gene complement(3005924..3007027) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /label="frlP gene" downshifts complement(3005939) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3007028..3007961) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 3007065..3007072 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3007086..3007105 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3007096 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3007147..3007153 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3007164 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3007168..3007187 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3007209..3007937 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" /label="frlR CDS" gene 3007209..3007937 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /label="frlR gene" CDS complement(3007962..3008816) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" /label="frlD CDS" gene complement(3007962..3008816) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /label="frlD gene" misc_feature complement(3008149..3008168) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3008161) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(3008319..3008419) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3008359) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3008830..3009732) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" /label="frlM CDS" gene complement(3008830..3009732) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /label="frlM gene" CDS complement(3009736..3010614) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" /label="frlN CDS" gene complement(3009736..3010614) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /label="frlN gene" CDS complement(3010672..3011940) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" /label="frlO CDS" gene complement(3010672..3011940) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /label="frlO gene" promotor_no_box 3011831..3011931 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3011891 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3012011) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS complement(3012021..3013007) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" /label="frlB CDS" gene complement(3012021..3013007) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /label="frlB gene" upshifts 3012954 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3012957..3012961 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3013050..3013069) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3013063) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3013084..3013091) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3013221) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3013223..3013597) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" /label="yurQ CDS" gene complement(3013223..3013597) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /label="yurQ gene" upshifts complement(3013661) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3013668..3013679) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3013693..3013699) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3013700..3014818) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" /label="dadA CDS" gene complement(3013700..3014818) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /label="dadA gene" promotor_-10 complement(3014843..3014862) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3014849) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3014851..3015461) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(3014876..3014882) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3014915..3014924 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3014938..3014957 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3014942 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3014955..3014970) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3014959) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3014977..3014981) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3014977..3015123 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" /label="sspG CDS" gene 3014977..3015123 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /label="sspG gene" CDS 3015123..3015398 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" /label="yurS CDS" gene 3015123..3015398 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /label="yurS gene" upshifts complement(3015267) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3015283..3015297) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3015306..3015310) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3015378 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3015462..3015845) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" /label="glxB CDS" gene complement(3015462..3015845) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /label="glxB gene" S_feature complement(3015846..3015955) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(3015956..3016234) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" /label="yuzN CDS" gene complement(3015956..3016234) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /label="yuzN gene" promotor_-10 complement(3016232..3016251) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3016256) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3016266..3016273) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3016397..3016503) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(3016440) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3016504..3017901) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" /label="sufB CDS" gene complement(3016504..3017901) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /label="sufB gene" downshifts 3017699 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS complement(3017922..3018365) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" /label="sufU CDS" gene complement(3017922..3018365) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /label="sufU gene" CDS complement(3018355..3019575) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" /label="sufS CDS" gene complement(3018355..3019575) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /label="sufS gene" CDS complement(3019575..3020888) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" /label="sufD CDS" gene complement(3019575..3020888) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /label="sufD gene" CDS complement(3020906..3021691) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" /label="sufC CDS" gene complement(3020906..3021691) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /label="sufC gene" promotor_-10 complement(3021735..3021754) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(3021736) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" promotor_-35 complement(3021768..3021775) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(3021792..3021811) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(3021801) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" S_feature complement(3021803..3021884) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(3021827..3021831) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(3021848..3022095) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" /label="bsrI RNA" gene complement(3021848..3022095) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /label="bsrI gene" CDS complement(3021885..3022022) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" /label="yuzK CDS" gene complement(3021885..3022022) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /label="yuzK gene" S_feature complement(3022023..3022107) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(3022091..3022110) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3022107) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3022109..3022215) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(3022126..3022129) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3022216..3022593) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" /label="yurZ CDS" gene complement(3022216..3022593) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /label="yurZ gene" promotor_-10 complement(3022610..3022621) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(3022616) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="upshifts" promotor_-35 complement(3022635..3022641) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(3022678..3023502) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" /label="metQ CDS" gene complement(3022678..3023502) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /label="metQ gene" downshifts complement(3022686) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(3022835) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-35 3022862..3022867 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3022883..3022901 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3022885 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3023516..3024184) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" /label="metP CDS" gene complement(3023516..3024184) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /label="metP gene" CDS complement(3024177..3025202) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" /label="metN CDS" gene complement(3024177..3025202) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /label="metN gene" S_feature complement(3025203..3025307) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(3025308..3025414) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswH RNA" gene complement(3025308..3025414) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /label="mswH gene" downshifts 3025377 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3025441..3025460) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3025453) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3025455..3025528) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(3025476..3025483) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3025529..3025873) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" /label="yusD CDS" gene complement(3025529..3025873) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /label="yusD gene" S_feature complement(3025874..3025979) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(3025980..3026300) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" /label="yusE CDS" gene complement(3025980..3026300) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /label="yusE gene" CDS complement(3026302..3026742) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" /label="yusF CDS" gene complement(3026302..3026742) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /label="yusF gene" CDS complement(3026742..3026978) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" /label="yusG CDS" gene complement(3026742..3026978) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /label="yusG gene" downshifts complement(3026754) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" /label="downshifts" upshifts complement(3026993) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3026998..3027009) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3027024..3027030) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3027034..3027417) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" /label="gcvH CDS" gene complement(3027034..3027417) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /label="gcvH gene" promotor_-10 complement(3027444..3027463) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(3027455) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="upshifts" promotor_-35 complement(3027476..3027483) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(3027484..3027840) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" /label="yusI CDS" gene complement(3027484..3027840) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /label="yusI gene" promotor_-10 complement(3027863..3027882) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(3027873) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="upshifts" promotor_-35 complement(3027896..3027901) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(3027951..3029735) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" /label="fadE CDS" gene complement(3027951..3029735) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /label="fadE gene" downshifts complement(3027961) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3029750..3030925) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " /label="fadA CDS" gene complement(3029750..3030925) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /label="fadA gene" CDS complement(3030936..3033305) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" /label="fadN CDS" gene complement(3030936..3033305) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /label="fadN gene" promotor_-35 3032724..3032729 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3032744..3032762 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3032747 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3033373..3033392) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(3033376) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="upshifts" S_feature complement(3033384..3033650) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(3033406..3033413) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 3033431..3033437 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3033452..3033463 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3033474 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="upshifts" CDS 3033480..3033626 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" /label="yuzL CDS" gene 3033480..3033626 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /label="yuzL gene" S_feature 3033627..3034653 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(3033651..3034559) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" /label="putM CDS" gene complement(3033651..3034559) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /label="putM gene" S_feature complement(3034560..3035082) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 3034654..3034899 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" /label="yuzM CDS" gene 3034654..3034899 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /label="yuzM gene" CDS 3034912..3035244 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" /label="yusN CDS" gene 3034912..3035244 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /label="yusN gene" promotor_-10 complement(3035065..3035084) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3035082) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3035098..3035107) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3035233 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3035305..3035312 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3035326..3035345 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3035337 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="upshifts" CDS 3035403..3035870 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" /label="mdtR CDS" gene 3035403..3035870 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /label="mdtR gene" CDS 3035867..3037492 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" /label="mdtP CDS" gene 3035867..3037492 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /label="mdtP gene" downshifts 3037477 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3037528..3037911) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" /label="yusQ CDS" gene complement(3037528..3037911) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /label="yusQ gene" CDS complement(3037930..3038319) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" /label="yusR CDS" gene complement(3037930..3038319) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /label="yusR gene" CDS complement(3038341..3038670) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" /label="yusS CDS" gene complement(3038341..3038670) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /label="yusS gene" promotor_-10 complement(3038705..3038724) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3038712..3038719 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3038719) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3038734..3038753 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3038738..3038745) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3038744 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="upshifts" CDS 3038804..3039691 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" /label="yusT CDS" gene 3038804..3039691 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /label="yusT gene" CDS complement(3039711..3039998) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" /label="yusU CDS" gene complement(3039711..3039998) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /label="yusU gene" downshifts complement(3039723) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(3040023..3040850) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " /label="feuV CDS" gene complement(3040023..3040850) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /label="feuV gene" downshifts complement(3040039) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" /label="downshifts" S_feature complement(3040851..3040988) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(3040973..3040992) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3040988) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3041008..3041011) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3041068..3041505) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" /label="cotNW CDS" gene complement(3041068..3041505) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /label="cotNW gene" promotor_-10 complement(3041529..3041547) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(3041535) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="upshifts" promotor_-35 complement(3041563..3041568) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(3041615..3043123) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" /label="yusYc CDS" gene complement(3041615..3043123) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo /label="yusYc gene" downshifts complement(3041636) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(3043114..3043410) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" /label="yusYn CDS" gene complement(3043114..3043410) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo /label="yusYn gene" promotor_-10 complement(3043433..3043452) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3043449) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3043467..3043470) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3043487..3043492 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3043504..3043523 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3043504 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="upshifts" CDS 3043544..3044386 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" /label="yusZ CDS" gene 3043544..3044386 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /label="yusZ gene" promotor_-35 3043916..3043922 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 3043937..3043948 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 3043945 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="upshifts" promotor_-35 3044413..3044420 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3044429 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3044432..3044451 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3044476..3044937 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" /label="mrgA CDS" gene 3044476..3044937 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /label="mrgA gene" downshifts 3044913 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3044981..3046357) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" /label="htrB CDS" gene complement(3044981..3046357) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /label="htrB gene" downshifts complement(3044989) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(3046358..3046529) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(3046510..3046529) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3046529) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3046540..3046547) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3046590..3046609) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 3046600..3046619 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3046602 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3046608) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="upshifts" S_feature complement(3046610..3047673) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(3046624..3046631) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 3046635..3047312 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" /label="cssR CDS" gene 3046635..3047312 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /label="cssR gene" CDS 3047309..3048664 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" /label="cssS CDS" gene 3047309..3048664 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /label="cssS gene" S_feature complement(3047763..3048691) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 3048632 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3048692..3048856) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" /label="spxO CDS" gene complement(3048692..3048856) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /label="spxO gene" promotor_-35 3048880..3048887 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3048901..3048920 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3048905..3048924) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3048911..3049023 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 3048911 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3048918) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3048920..3049198) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(3048938..3048945) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3049024..3049899 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" /label="yuxN CDS" gene 3049024..3049899 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /label="yuxN gene" promotor_-10 complement(3049188..3049207) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3049198) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3049200..3049741) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(3049221..3049228) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3049733..3049751) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3049741) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3049743..3049872) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(3049764..3049771) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3049874 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" downshifts complement(3049917) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(3049935..3051323) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" /label="fumC CDS" gene complement(3049935..3051323) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /label="fumC gene" upshifts complement(3051347) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3051352..3051370) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3051381..3051389) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3051390..3051575) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" /label="yvzF CDS" gene complement(3051390..3051575) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /label="yvzF gene" downshifts 3051579 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3051619..3051638) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3051628..3051634 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3051633) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3051648..3051659 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3051651 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3051654..3051657) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3051693..3053141 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" /label="gerAA CDS" gene 3051693..3053141 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /label="gerAA gene" S_feature complement(3052689..3055332) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 3053110..3054207 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" /label="gerAB CDS" gene 3053110..3054207 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /label="gerAB gene" CDS 3054204..3055325 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" /label="gerAC CDS" gene 3054204..3055325 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /label="gerAC gene" CDS complement(3055333..3055968) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" /label="liaR CDS" gene complement(3055333..3055968) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /label="liaR gene" CDS complement(3055946..3057028) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" /label="liaS CDS" gene complement(3055946..3057028) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /label="liaS gene" CDS complement(3057025..3057750) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" /label="liaF CDS" gene complement(3057025..3057750) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /label="liaF gene" CDS complement(3057784..3058656) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" /label="liaG CDS" gene complement(3057784..3058656) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /label="liaG gene" promotor_-10 complement(3058675..3058694) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3058695) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3058709..3058712) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3058757..3059434) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" /label="liaH CDS" gene complement(3058757..3059434) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /label="liaH gene" downshifts complement(3058773) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" /label="downshifts" CDS complement(3059461..3059841) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" /label="liaI CDS" gene complement(3059461..3059841) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /label="liaI gene" promotor_-10 complement(3059864..3059883) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3059884) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3059898..3059901) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3060003..3061271) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" /label="yvqJ CDS" gene complement(3060003..3061271) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /label="yvqJ gene" downshifts complement(3060016) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3061305..3061324) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3061316) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3061339..3061346) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3061442) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(3061448..3062029) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" /label="yvqK CDS" gene complement(3061448..3062029) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /label="yvqK gene" CDS complement(3062052..3063380) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" /label="yvrA CDS" gene complement(3062052..3063380) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /label="yvrA gene" CDS complement(3063380..3064441) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" /label="yvrB CDS" gene complement(3063380..3064441) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /label="yvrB gene" CDS complement(3064404..3065348) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" /label="yvrC CDS" gene complement(3064404..3065348) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /label="yvrC gene" S_feature complement(3065349..3065618) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(3065457..3065587) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" /label="srbL RNA" gene complement(3065457..3065587) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /label="srbL gene" promotor_-10 complement(3065595..3065614) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3065618) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3065620..3066547) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(3065630..3065637) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3065680..3065687 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3065702..3065721 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3065706 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="upshifts" CDS 3065746..3066537 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" /label="yvrD CDS" gene 3065746..3066537 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /label="yvrD gene" downshifts 3066408 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3066518 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3066575..3067453) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" /label="yvrE CDS" gene complement(3066575..3067453) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /label="yvrE gene" downshifts complement(3066592) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3067477..3067495) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3067496) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3067509..3067515) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3067525..3069267) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" /label="yvrG CDS" gene complement(3067525..3069267) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /label="yvrG gene" CDS complement(3069264..3069977) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" /label="yvrH CDS" gene complement(3069264..3069977) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /label="yvrH gene" misc_feature complement(3070008..3070027) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3070026) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="upshifts" CDS complement(3070130..3070369) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" /label="rsoA CDS" gene complement(3070130..3070369) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /label="rsoA gene" downshifts complement(3070137) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3070365..3070383) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3070373..3070903) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" /label="sigO CDS" gene complement(3070373..3070903) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /label="sigO gene" upshifts complement(3070374) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3070398..3070404) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3070906..3070925) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3070913) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" CDS 3070918..3071256 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" /label="yvrJ CDS" gene 3070918..3071256 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /label="yvrJ gene" promotor_-35 complement(3070940..3070947) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3070956..3070975) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3070968) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3070990..3070996) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 3071002..3071102 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 3071062 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="upshifts" promotor_no_box 3071230..3071330 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 3071290..3071376 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 3071290 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="upshifts" CDS 3071377..3072534 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" /label="oxdC CDS" gene 3071377..3072534 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /label="oxdC gene" downshifts 3072520 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3072595..3073005 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" /label="rsiO CDS" gene 3072595..3073005 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /label="rsiO gene" downshifts 3073004 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3073039..3074268) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" /label="yvrN CDS" gene complement(3073039..3074268) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /label="yvrN gene" downshifts complement(3073056) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(3074261..3074950) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" /label="yvrO CDS" gene complement(3074261..3074950) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /label="yvrO gene" CDS complement(3074934..3076127) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" /label="yvrP CDS" gene complement(3074934..3076127) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /label="yvrP gene" promotor_-10 complement(3076171..3076190) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3076184) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3076205..3076212) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3076298..3077107) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" /label="fhuC CDS" gene complement(3076298..3077107) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /label="fhuC gene" downshifts complement(3076315) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3076454..3076463 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3076476..3076495 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3076480 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3077123..3078133) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" /label="fhuG CDS" gene complement(3077123..3078133) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /label="fhuG gene" CDS complement(3078133..3079287) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" /label="fhuB CDS" gene complement(3078133..3079287) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /label="fhuB gene" promotor_-10 complement(3079220..3079239) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3079237) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3079251..3079258) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3079299..3079306 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3079321..3079340 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3079330 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="upshifts" CDS 3079385..3080332 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" /label="fhuD CDS" gene 3079385..3080332 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /label="fhuD gene" downshifts 3080308 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 3080352 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 3080506 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(3080567..3081976) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" /label="lysP CDS" gene complement(3080567..3081976) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /label="lysP gene" downshifts complement(3080582) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3081394..3081398 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3081416..3081432 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3081423 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="upshifts" S_feature 3081430..3082397 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(3082078) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3082080..3082259) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" /label="kswB RNA" gene complement(3082080..3082259) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /label="kswB gene" promotor_-10 complement(3082289..3082306) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3082300) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3082321..3082328) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3082354 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3082376..3082516) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" /label="sspJ CDS" gene complement(3082376..3082516) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /label="sspJ gene" downshifts complement(3082386) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" upshifts complement(3082544) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="upshifts" S_feature complement(3082546..3083134) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(3082549..3082560) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(3082574..3082580) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 3082606..3082613 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3082627 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3082629..3082648 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3082683..3083165 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" /label="yvsG CDS" gene 3082683..3083165 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /label="yvsG gene" promotor_-35 3083179..3083186 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3083200..3083219 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3083212 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3083265..3085118 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" /label="ltaSP CDS" gene 3083265..3085118 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /label="ltaSP gene" downshifts 3085104 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3085146..3086072) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" /label="yvgK CDS" gene complement(3085146..3086072) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /label="yvgK gene" downshifts complement(3085158) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3086084..3086103) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3086105) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3086119..3086122) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3086141..3086160 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3086150 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="upshifts" CDS 3086183..3086965 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" /label="modA CDS" gene 3086183..3086965 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /label="modA gene" CDS 3086937..3087629 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" /label="modB CDS" gene 3086937..3087629 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /label="modB gene" downshifts 3087621 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" /label="downshifts" CDS complement(3087660..3088490) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" /label="pgoN CDS" gene complement(3087660..3088490) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /label="pgoN gene" downshifts complement(3087666) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 3088353..3088357 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3088373..3088377 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3088382 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3088492 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3088520..3088539) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3088538) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3088554..3088561) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3088646..3088652 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3088666 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3088667..3088685 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3088713..3089198 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" /label="yvgO CDS" gene 3088713..3089198 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /label="yvgO gene" downshifts 3089197 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" /label="downshifts" CDS complement(3089242..3091254) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" /label="nhaK CDS" gene complement(3089242..3091254) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /label="nhaK gene" downshifts complement(3089250) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3090920..3090924) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3090922) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3091255..3091406) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(3091383..3091401) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3091406) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3091509..3093224) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" /label="cysI CDS" gene complement(3091509..3093224) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /label="cysI gene" downshifts complement(3091516) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" CDS complement(3093250..3095067) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" /label="cysJ CDS" gene complement(3093250..3095067) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /label="cysJ gene" promotor_-10 complement(3095109..3095128) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3095118..3095125 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3095128) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" upshifts 3095131 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3095138..3095157 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3095141..3095148) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3095238..3097562) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" /label="helD CDS" gene complement(3095238..3097562) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /label="helD gene" downshifts complement(3095256) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3097582..3097589 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3097604..3097623 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(3097605..3097620) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3097608 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3097610) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3097655..3097674) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3097664) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3097690..3097696) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3097700..3097719) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3097720) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3097733..3097741) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3097747) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" /label="downshifts" CDS complement(3097760..3098368) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" /label="yvgT CDS" gene complement(3097760..3098368) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /label="yvgT gene" promotor_-10 complement(3098407..3098426) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3098424) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3098442..3098446) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3098555..3098971) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" /label="bdbC CDS" gene complement(3098555..3098971) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /label="bdbC gene" downshifts complement(3098565) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(3098976..3099644) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" /label="bdbD CDS" gene complement(3098976..3099644) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /label="bdbD gene" promotor_-10 complement(3099696..3099715) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3099711) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3099722) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3099729..3099734) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3099764..3101872) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" /label="cadA CDS" gene complement(3099764..3101872) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /label="cadA gene" S_feature complement(3101864..3101965) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(3101959..3101978) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3101965) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3101994..3102001) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3102032..3104440) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" /label="copA CDS" gene complement(3102032..3104440) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /label="copA gene" downshifts complement(3102054) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3102120) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3104441..3104523) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(3104524..3104733) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" /label="copZ CDS" gene complement(3104524..3104733) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /label="copZ gene" promotor_-10 complement(3104757..3104776) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(3104778) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="upshifts" promotor_-35 complement(3104789..3104795) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(3104807..3105112) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " /label="csoR CDS" gene complement(3104807..3105112) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /label="csoR gene" misc_feature 3105076..3105095 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3105087 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3105126..3105145) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(3105152) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="upshifts" promotor_-35 complement(3105159..3105165) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 3105204..3105210 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3105225..3105243 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3105233 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="upshifts" CDS 3105240..3106316 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" /label="iolW CDS" gene 3105240..3106316 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /label="iolW gene" downshifts 3106303 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(3106353..3106988) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" /label="azoRB CDS" gene complement(3106353..3106988) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /label="azoRB gene" downshifts complement(3106366) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3106989..3107086) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(3107066..3107085) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3107086) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3107099..3107105) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3107148..3109043) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" /label="yvaC CDS" gene complement(3107148..3109043) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /label="yvaC gene" promotor_-10 complement(3109094..3109105) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3109094) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3109120..3109126) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3109193) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3109206..3109607) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" /label="yvaD CDS" gene complement(3109206..3109607) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /label="yvaD gene" CDS complement(3109604..3109963) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" /label="yvaE CDS" gene complement(3109604..3109963) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /label="yvaE gene" CDS complement(3109960..3110532) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" /label="yvaF CDS" gene complement(3109960..3110532) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /label="yvaF gene" promotor_-10 complement(3110570..3110589) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3110575) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3110603..3110610) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3110643..3111437) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" /label="yvaG CDS" gene complement(3110643..3111437) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /label="yvaG gene" promotor_-10 complement(3111458..3111476) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3111470) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3111491..3111497) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3111503..3111522) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3111514) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3111516..3111581) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(3111536..3111543) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(3111623..3111982) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" /label="ssrA RNA" gene complement(3111623..3111982) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /label="ssrA gene" downshifts complement(3111626) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3111966..3111974) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3111976) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3111989..3111994) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3112034..3112053) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3112042) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3112044..3112108) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(3112066..3112070) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3112108) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="upshifts" promotor_-10 complement(3112109..3112128) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(3112143..3112150) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(3112159..3112629) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" /label="smpB CDS" gene complement(3112159..3112629) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /label="smpB gene" promotor_no_box 3112456..3112556 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3112516 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3112626 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3112674..3112693) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(3112680) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" S_feature complement(3112682..3112773) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(3112709..3112712) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(3112774..3115113) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" /label="rnr CDS" gene complement(3112774..3115113) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /label="rnr gene" promotor_-35 3113874..3113877 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3113893..3113896 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3113902 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3115132..3115872) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" /label="estA CDS" gene complement(3115132..3115872) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /label="estA gene" promotor_-10 complement(3115528..3115546) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(3115540) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="upshifts" promotor_-35 complement(3115561..3115567) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(3115900..3115918) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3115914) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="upshifts" downshifts complement(3116002) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" /label="downshifts" CDS complement(3116004..3116234) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" /label="secG CDS" gene complement(3116004..3116234) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /label="secG gene" promotor_-10 complement(3116264..3116283) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(3116285) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" promotor_-35 complement(3116298..3116301) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 3116323..3116329 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3116343..3116354 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3116344 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="upshifts" CDS 3116383..3117153 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" /label="yvaM CDS" gene 3116383..3117153 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /label="yvaM gene" promotor_-35 3116405..3116413 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3116424..3116442 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3116454 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3117193..3117426) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" /label="yvzC CDS" gene complement(3117193..3117426) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /label="yvzC gene" promotor_-35 3117517..3117524 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 3117532 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="upshifts" promotor_-10 3117536..3117555 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 3117578..3117985 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" /label="rghRA CDS" gene 3117578..3117985 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /label="rghRA gene" CDS 3118015..3118434 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" /label="rghRB CDS" gene 3118015..3118434 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /label="rghRB gene" promotor_-35 3118472..3118479 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3118493..3118512 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3118500 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 3118526..3118852 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" /label="catR CDS" gene 3118526..3118852 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /label="catR gene" S_feature 3118853..3118937 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 3118908..3118915 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3118928..3118946 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3118939 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 3118977..3120677 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" /label="yvaQ CDS" gene 3118977..3120677 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /label="yvaQ gene" S_feature complement(3119693..3120686) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 3120655 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3120717..3121397) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" /label="opuBD CDS" gene complement(3120717..3121397) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /label="opuBD gene" downshifts complement(3120731) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3121091..3121097 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3121112..3121130 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3121117..3123868 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 3121117 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3121414..3122334) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" /label="opuBC CDS" gene complement(3121414..3122334) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /label="opuBC gene" CDS complement(3122346..3122999) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " /label="opuBB CDS" gene complement(3122346..3122999) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /label="opuBB gene" CDS complement(3123016..3124161) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" /label="opuBA CDS" gene complement(3123016..3124161) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /label="opuBA gene" S_feature complement(3124162..3124229) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(3124229) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3124230..3124249) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3124260..3124264 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3124264..3124267) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3124280..3124298 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3124285 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3124380..3124384 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3124400..3124419 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3124403 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" CDS 3124445..3124978 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" /label="yvaV CDS" gene 3124445..3124978 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /label="yvaV gene" S_feature complement(3124645..3125164) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 3124967 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3125101..3125108 /Source="Nicolas_upshift_promotors" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3125121..3125199 /Source="Nicolas_S_feature" /locus_tag="new_3464210_3464288" /HighExp="T-1.10H, T2.30H, T4.0H, T5.0H, T-2.40H, T2.0H, T-0.40H, M9-stat, T-5.40H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1293" upshifts 3125121 /Source="Nicolas_upshifts" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3125123..3125142 /Source="Nicolas_upshift_promotors" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3125149..3125163) /Source="Nicolas_upshift_promotors" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3125164) /Source="Nicolas_upshifts" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" /label="upshifts" CDS 3125200..3125676 /gene="sdpA" /locus_tag="BSU_33750" /old_locus_tag="BSU33750" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16469701, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16469701, 17069462, 23687264; Product type f: factor" /codon_start=1 /transl_table=11 /product="export step of killing factor SdpC" /protein_id="NP_391255.1" /db_xref="EnsemblGenomes-Gn:BSU33750" /db_xref="EnsemblGenomes-Tr:CAB15380" /db_xref="GOA:O34889" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG14074" /db_xref="UniProtKB/Swiss-Prot:O34889" /translation="MTICFLLFSSYYFSNISPQNPLFKKNFLQQLSPQGFGFYSKSPT EENISFHTKENLKLPNALPNNFFGIKREGRVQAIELGKIVENIDPKNWKTCENNNSCT NLEKQIKPIKVIKNEDYIHLSKGEYLIYRQKPLSWYWIDFKQTTSFERKVLKIKIV*" /label="sdpA CDS" gene 3125200..3125676 /gene="sdpA" /locus_tag="BSU_33750" /old_locus_tag="BSU33750" /label="sdpA gene" promotor_-10 complement(3125225..3125244) /Source="Nicolas_upshift_promotors" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3125235) /Source="Nicolas_upshifts" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3125256..3125263) /Source="Nicolas_upshift_promotors" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3125673..3126644 /gene="sdpB" /locus_tag="BSU_33760" /old_locus_tag="BSU33760" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16469701, 16850406, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16469701, 16850406, 17069462, 23687264; Product type t : transporter" /codon_start=1 /transl_table=11 /product="export step of killing factor SdpC" /protein_id="NP_391256.1" /db_xref="EnsemblGenomes-Gn:BSU33760" /db_xref="EnsemblGenomes-Tr:CAB15381" /db_xref="GOA:O34616" /db_xref="InterPro:IPR007782" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG14075" /db_xref="UniProtKB/Swiss-Prot:O34616" /translation="MKILNSLEGYIDTYNPWKNTYALFRSLLGFSTLLVLLFNSTDIL FSYSANNVTCENVYIPTAFCFAKEYSINFEIIRYLMIFILTLVVIGWRPRFTGLFHWY ICYSIQTSALTIDGGEQIATVLSFLILPVTLLDSRRNHWNIKKNNNESFTKKTVLFYI MTIIKIQVFIIYLNAALERLKNKEWAEGTAIYYFFSDPVFGLPEYQLNLMNPLLESNF IVVITWLVTIFELFLAASIISNIRIKRIALVLGILFHIGIIFSIGIVSFGLIMISALI IYLHPVQQNITMNWCSPLFKYIYVKGKRNFKRIGGESVKFLTKLFHS*" /label="sdpB CDS" gene 3125673..3126644 /gene="sdpB" /locus_tag="BSU_33760" /old_locus_tag="BSU33760" /label="sdpB gene" promotor_no_box 3126481..3126581 /Source="Nicolas_upshift_promotors" /id="U2663" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.457542457542458" /psig="0.636363636363636" /xcortree=2869 /SigmaFactorBS="tcatgatatcagcattaattatatatctgcatcctgtacaac aaaatatcactatgaattggtgttctcctttatttaaatatatatatgtaaaaggaaa g" /listShort="spbC, S1297" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3126541 /Source="Nicolas_upshifts" /id="U2663" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.457542457542458" /psig="0.636363636363636" /xcortree=2869 /SigmaFactorBS="tcatgatatcagcattaattatatatctgcatcctgtacaac aaaatatcactatgaattggtgttctcctttatttaaatatatatatgtaaaaggaaa g" /listShort="spbC, S1297" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3126553..3126570) /Source="Nicolas_upshift_promotors" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3126574) /Source="Nicolas_upshifts" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3126576..3126978) /Source="Nicolas_S_feature" /locus_tag="new_3465665_3466067_c" /HighExp="Gly, Lbstat, BT, S8, T1.30H, C30, M9-stat, C90, Sw, HiTm" /AntisenseName="spbC" /AntisenseCor="-0.16053929530879699" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1294" promotor_-35 complement(3126587..3126589) /Source="Nicolas_upshift_promotors" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3126605) /Source="Nicolas_upshifts" /id="D1751" /incds=0 /nref=1 /ntot=33 /MaxReadThrough="3.26001" /MaxDrop="4.09728" /score="-7.06061287" /energy="-10.3" /TU="NA" /idTUdmin="U2665" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 3126687..3127298 /gene="spbC" /locus_tag="BSU_33770" /old_locus_tag="BSU33770" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 16469701, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 16469701, 17069462, 23687264; Product type f: factor" /codon_start=1 /transl_table=11 /product="precursor of killing factor SdpC" /protein_id="NP_391257.1" /db_xref="EnsemblGenomes-Gn:BSU33770" /db_xref="EnsemblGenomes-Tr:CAB15382" /db_xref="GOA:O34344" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG14076" /db_xref="UniProtKB/Swiss-Prot:O34344" /translation="MKSKLLRLLIVSMVTILVFSLVGLSKESSTSAKENHTFSGEDYF RGLLFGQGEVGKLISNDLDPKLVKEANSTEGKKLVNDVVKFIKKDQPQYMDELKQSID SKDPKKLIENMTKADQLIQKYAKKNENVKYSSNKVTPSCGLYAVCVAAGYLYVVGVNA VALQTAAAVTTAVWKYVAKYSSSASNNSDLEAAAAKTLKLIHQ*" /label="spbC CDS" gene 3126687..3127298 /gene="spbC" /locus_tag="BSU_33770" /old_locus_tag="BSU33770" /label="spbC gene" S_feature complement(3126980..3127066) /Source="Nicolas_S_feature" /locus_tag="new_3466069_3466155_c" /HighExp="T1.30H, Gly, T2.0H, BT, S8, C30, Lbstat, C90, T1.0H, M9-stat" /AntisenseName="spbC" /AntisenseCor="-5.4790207146846799E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1295" downshifts complement(3127023) /Source="Nicolas_upshifts" /id="D1752" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="4.62458" /MaxDrop="2.00358" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2665" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature complement(3127068..3127253) /Source="Nicolas_S_feature" /locus_tag="new_3466157_3466342_c" /HighExp="T1.30H, T2.0H, M9-stat, T1.0H, B60, T2.30H, T5.0H, B36, T3.30H, T0.30H" /AntisenseName="spbC" /AntisenseCor="-4.2394313806342503E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1296" downshifts complement(3127111) /Source="Nicolas_upshifts" /id="D1753" /incds=1 /nref=1 /ntot=14 /MaxReadThrough="4.27088" /MaxDrop="2.27366" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2665" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3127278 /Source="Nicolas_upshifts" /id="D1754" /incds=0 /nref=207 /ntot=252 /MaxReadThrough="4.65014" /MaxDrop="7.52715" /score="19.8036228" /energy="-20" /TU="U2660,U2663" /idTUdmin="U2660" /TUdmin="-1099" /isTUend="FALSE" /label="downshifts" downshifts complement(3127298) /Source="Nicolas_upshifts" /id="D1755" /incds=0 /nref=14 /ntot=94 /MaxReadThrough="6.14809" /MaxDrop="5.58575" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2667" /TUdmin=33 /isTUend="FALSE" /label="downshifts" S_feature 3127323..3128461 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" CDS complement(3127345..3127968) /gene="sdpI" /locus_tag="BSU_33780" /old_locus_tag="BSU33780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12817086, 15849754, 16850406, 20563570, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12817086, 15849754, 16850406, 20563570, 23687264; Product type r: regulator" /codon_start=1 /transl_table=11 /product="integral membrane immunity regulator of autophagy" /protein_id="NP_391258.1" /db_xref="EnsemblGenomes-Gn:BSU33780" /db_xref="EnsemblGenomes-Tr:CAB15383" /db_xref="GOA:O32241" /db_xref="InterPro:IPR012867" /db_xref="InterPro:IPR025962" /db_xref="InterPro:IPR026272" /db_xref="SubtiList:BG14077" /db_xref="UniProtKB/Swiss-Prot:O32241" /translation="MKKNIISIIIVCLSFLTSIILYQYLPEEIPIQWSGNKPAAIVSK PLTIFIIPVVMLIYYLTFYMLTIKSTQKNKALLFLASNNMLILLYILQLSTLLISLGY EVNIDLIIGLGVGIFLIIGGNSMQLAEQNHLIGLRTPWTLKDETVWKLGNRFASKVLV VCGFIIAVLSFFTGEYIILIMIVLVLLALVISTLASYHYYKKLNGSR*" /label="sdpI CDS" gene complement(3127345..3127968) /gene="sdpI" /locus_tag="BSU_33780" /old_locus_tag="BSU33780" /label="sdpI gene" downshifts complement(3127353) /Source="Nicolas_upshifts" /id="D1756" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="6.43517" /MaxDrop="3.3455" /score="8.72167152" /energy="-11.6" /TU="U2665,U2667" /idTUdmin="U2667" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3127965..3128237) /gene="sdpR" /locus_tag="BSU_33790" /old_locus_tag="BSU33790" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12817086, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12817086, 17069462, 23687264; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of SdpC synthesis operon (ArsR family)" /protein_id="NP_391259.1" /db_xref="EnsemblGenomes-Gn:BSU33790" /db_xref="EnsemblGenomes-Tr:CAB15384" /db_xref="GOA:O32242" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14078" /db_xref="UniProtKB/Swiss-Prot:O32242" /translation="MNNVFKAISDPTRRKILDLLKGGDMTAGDIAEHFNISKPSISHH LNILKQAEVISDHRKGQFIYYSLNTTVLQDSINWMLNFINKGDNDL*" /label="sdpR CDS" gene complement(3127965..3128237) /gene="sdpR" /locus_tag="BSU_33790" /old_locus_tag="BSU33790" /label="sdpR gene" promotor_-10 complement(3128293..3128312) /Source="Nicolas_upshift_promotors" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3128302) /Source="Nicolas_upshifts" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3128304..3128452) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" promotor_-35 complement(3128324..3128330) /Source="Nicolas_upshift_promotors" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3128457..3129146) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" /label="opuCD CDS" gene complement(3128457..3129146) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /label="opuCD gene" downshifts complement(3128497) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" promotor_-35 3129089..3129097 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3129111..3129130 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3129125 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3129164..3130075) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" /label="opuCC CDS" gene complement(3129164..3130075) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /label="opuCC gene" CDS complement(3130095..3130748) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " /label="opuCB CDS" gene complement(3130095..3130748) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /label="opuCB gene" CDS complement(3130771..3131913) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" /label="opuCA CDS" gene complement(3130771..3131913) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /label="opuCA gene" promotor_-10 complement(3131957..3131976) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(3131972) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="upshifts" promotor_-35 complement(3131991..3131994) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 3132110..3132117 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3132130..3132149 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3132141 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="upshifts" CDS 3132177..3132734 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" /label="opcR CDS" gene 3132177..3132734 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /label="opcR gene" S_feature 3132735..3133499 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(3132752..3133387) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" /label="yvbG CDS" gene complement(3132752..3133387) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /label="yvbG gene" downshifts complement(3132765) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3133428..3133446) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3133434) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3133462..3133468) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3133473..3133480 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3133492..3133511 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3133501 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 3133537..3134151 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" /label="yvbH CDS" gene 3133537..3134151 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /label="yvbH gene" downshifts 3134137 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 3134205..3134208 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3134223..3134242 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3134231 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 3134283..3134981 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" /label="yvbI CDS" gene 3134283..3134981 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /label="yvbI gene" downshifts 3134954 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(3135017..3136834) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" /label="yvbJ CDS" gene complement(3135017..3136834) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /label="yvbJ gene" downshifts complement(3135036) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(3135207) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" misc_feature complement(3136876..3136895) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 3136880..3136899 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3136885 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3136889) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3136954..3137421 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" /label="yvbK CDS" gene 3136954..3137421 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /label="yvbK gene" downshifts 3137418 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(3137466..3138758) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" /label="eno CDS" gene complement(3137466..3138758) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /label="eno gene" downshifts complement(3137476) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3138788..3140323) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" /label="pgm CDS" gene complement(3138788..3140323) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /label="pgm gene" CDS complement(3140316..3141077) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" /label="tpiA CDS" gene complement(3140316..3141077) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /label="tpiA gene" CDS complement(3141108..3142292) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" /label="pgk CDS" gene complement(3141108..3142292) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /label="pgk gene" S_feature complement(3142293..3142533) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(3142533) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3142535..3142608) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(3142547..3142566) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3142582..3142586) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3142609..3143616) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" /label="gapA CDS" gene complement(3142609..3143616) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /label="gapA gene" promotor_-35 3143535..3143538 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3143555..3143557 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3143557 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3143663..3144685) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" /label="cggR CDS" gene complement(3143663..3144685) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /label="cggR gene" upshifts complement(3143679) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3143707..3143708) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3144686..3144797) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 3144723 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3144778..3144797) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3144797) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3144799..3144909) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(3144811..3144818) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3144892..3144911) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(3144907) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="upshifts" promotor_-35 complement(3144924..3144933) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(3144983..3146377) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" /label="araE CDS" gene complement(3144983..3146377) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /label="araE gene" downshifts complement(3144997) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3146476..3146495) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3146490) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3146510..3146517) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3146517..3146524 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3146538..3146557 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3146544 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="upshifts" CDS 3146581..3147669 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" /label="araR CDS" gene 3146581..3147669 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /label="araR gene" downshifts 3147649 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3147718..3148728) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" /label="yvbT CDS" gene complement(3147718..3148728) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /label="yvbT gene" downshifts complement(3147725) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3148729..3148806) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(3148796..3148815) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3148806) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3148829..3148836) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3148885..3149763) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" /label="yvbU CDS" gene complement(3148885..3149763) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /label="yvbU gene" promotor_-35 3149421..3149427 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3149442..3149453 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3149453 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3149797..3149804 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3149810..3149829) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(3149815) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="upshifts" promotor_-10 3149818..3149837 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3149820 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3149843..3149847) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 3149863..3150780 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" /label="cyeB CDS" gene 3149863..3150780 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /label="cyeB gene" downshifts 3150769 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3150821..3152164) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" /label="yvbW CDS" gene complement(3150821..3152164) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /label="yvbW gene" misc_RNA complement(3152233..3152468) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" /label="tboX RNA" gene complement(3152233..3152468) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /label="tboX gene" downshifts complement(3152367) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3152469..3152565) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(3152566..3153600) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" /label="yvbX CDS" gene complement(3152566..3153600) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /label="yvbX gene" promotor_-10 complement(3153622..3153640) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3153628) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3153653..3153660) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3153708..3154430) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" /label="lutC CDS" gene complement(3153708..3154430) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /label="lutC gene" downshifts complement(3153724) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" /label="downshifts" CDS complement(3154430..3155869) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" /label="lutB CDS" gene complement(3154430..3155869) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /label="lutB gene" promotor_-35 3155417..3155420 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3155437 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3155438..3155442 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 3155591 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3155745 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3155746..3155747 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3155896..3156612) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" /label="lutA CDS" gene complement(3155896..3156612) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /label="lutA gene" promotor_-35 3156516..3156523 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3156537..3156539 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3156537 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3156610 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" S_feature complement(3156613..3156679) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(3156676..3156695) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(3156679) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="upshifts" promotor_-35 complement(3156710..3156717) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(3156787..3157389) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" /label="yvfU CDS" gene complement(3156787..3157389) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /label="yvfU gene" CDS complement(3157406..3158521) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" /label="yvfT CDS" gene complement(3157406..3158521) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /label="yvfT gene" CDS complement(3158525..3159262) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" /label="yvfS CDS" gene complement(3158525..3159262) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /label="yvfS gene" promotor_-10 complement(3158551..3158570) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(3158565) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="upshifts" promotor_-35 complement(3158582..3158589) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(3159263..3160168) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" /label="yvfR CDS" gene complement(3159263..3160168) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /label="yvfR gene" promotor_-10 complement(3160188..3160206) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3160199) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3160222..3160225) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3160377..3160384 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3160395..3160414 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3160402 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="upshifts" CDS 3160452..3161261 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" /label="rsbQ CDS" gene 3160452..3161261 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /label="rsbQ gene" CDS 3161297..3162508 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" /label="rsbP CDS" gene 3161297..3162508 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /label="rsbP gene" downshifts 3162495 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3162562..3163851) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" /label="ganB CDS" gene complement(3162562..3163851) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /label="ganB gene" CDS complement(3163931..3165994) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" /label="ganA CDS" gene complement(3163931..3165994) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /label="ganA gene" CDS complement(3166013..3166864) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" /label="ganQ CDS" gene complement(3166013..3166864) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /label="ganQ gene" CDS complement(3166868..3168124) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" /label="ganP CDS" gene complement(3166868..3168124) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /label="ganP gene" CDS complement(3168164..3169429) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" /label="ganS CDS" gene complement(3168164..3169429) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /label="ganS gene" promotor_-10 complement(3169461..3169480) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3169483) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3169495..3169502) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3169570..3170562) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" /label="ganR CDS" gene complement(3169570..3170562) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /label="ganR gene" downshifts complement(3169604) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" /label="downshifts" S_feature complement(3170692..3170741) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(3170715) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3170742..3171401) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" /label="lutR CDS" gene complement(3170742..3171401) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /label="lutR gene" S_feature complement(3171402..3171507) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(3171499..3171518) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3171508) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3171533..3171536) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3171560..3171567 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3171582..3171601 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3171582 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="upshifts" S_feature 3171585..3171690 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(3171591..3171608) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3171595) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3171616..3171622) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3171691..3173382 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" /label="lutP CDS" gene 3171691..3173382 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /label="lutP gene" downshifts 3173367 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3173409..3174719) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" /label="sigL CDS" gene complement(3173409..3174719) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /label="sigL gene" S_feature 3173412..3174482 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(3173421) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3174539..3174558 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3174539..3174797 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 3174539 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3174733..3174752) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3174748) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3174767..3174770) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3174798..3175016 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" /label="yvfG CDS" gene 3174798..3175016 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /label="yvfG gene" downshifts 3174995 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3175026..3175994) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1097084, 115661000, 20720312, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvyl transferase for matrix biofilm formation" /protein_id="NP_391302.1" /db_xref="EnsemblGenomes-Gn:BSU34220" /db_xref="EnsemblGenomes-Tr:CAB15427" /db_xref="GOA:P71065" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11874" /db_xref="UniProtKB/Swiss-Prot:P71065" /translation="MDSKHSMISLKQKLSGLLDVIPKQSEIIYADYPLYGNVGDLFIM KGTEAFFKEHGIRVRKRWNPDNFPIGRKLDPNLIIVCQGGGNFGDLYPYYQGFREKIV QTYPNHKIVILPQSIYFQNKDNLKRTAEIFSKHANLHIMTREKASYATAQAYFTTNHI QLLPDMAHQLFPVIPTQQPSNQKLRFIRTDHEANQALQEHAEAESYDWRTVLSASDRR TIAFLQTLNVLNKKAGNPLPIAYIWEKYSDYIVQKAIRFFSRYESVETSRLHGHILSS LLQKENTVIDNSYGKNANYFHTWMEGVPSTRLIQHASKKENLPAHM*" /label="epsO CDS" gene complement(3175026..3175994) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" /label="epsO gene" CDS complement(3175973..3177139) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" /EC_number="2.6.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 23378512, 27084765, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase involved in biofilm matrix formation" /protein_id="NP_391303.2" /db_xref="EnsemblGenomes-Gn:BSU34230" /db_xref="EnsemblGenomes-Tr:CAB15428" /db_xref="GOA:Q795J3" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11873" /db_xref="UniProtKB/Swiss-Prot:Q795J3" /translation="MHKKIYLSPPHMSGREQHYISEAFRSNWIAPLGPLVNSFEEQLA ERVGVKAAAAVGSGTAAIHLALRLLEVKEGDSVFCQSFTFVATANPILYEKAVPVFID SEPDTWNMSPTALERALEEAKRNGTLPKAVIAVNLYGQSAKMDEIVSLCDAYGVPVIE DAAESLGTVYKGKQSGTFGRFGIFSFNGNKIITTSGGGMLVSNDEAAIEKARFLASQA REPAVHYQHSEIGHNYRLSNILAGVGIAQLEVLDERVEKRRTIFTRYKNALGHLDGVR FMPEYAAGVSNRWLTTLTLDNGLSPYDIVQRLAEENIEARPLWKPLHTQPLFDPALFY SHEDTGSVCEDLFKRGICLPSGSNMTEDEQGRVIEVLLHLFHTVEVKKWTASIR*" /label="epsN CDS" gene complement(3175973..3177139) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" /label="epsN gene" CDS complement(3177144..3177794) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative O-acetyltransferase involved in biofilmmatrix formation" /protein_id="NP_391304.1" /db_xref="EnsemblGenomes-Gn:BSU34240" /db_xref="EnsemblGenomes-Tr:CAB15429" /db_xref="GOA:P71063" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR020019" /db_xref="SubtiList:BG11872" /db_xref="UniProtKB/Swiss-Prot:P71063" /translation="MKNVAIVGDGGHGKVIRELINARSDTRLAAVLDDKFKTFEGGKE WYTGPPKAVTELRRLIPDVLFLIAVGNNSVRKQLAERLGLGKDDFITLIHPSAIVSKS AVIGEGTVIMAGAIIQADARIGAHCIINTGAVAEHDNQISDYVHLSPRATLSGAVSVQ EGAHVGTGASVIPQIIIGAWSIVGAGSAVIRSIPDRVTAAGAPARIISSIQTSNKG*" /label="epsM CDS" gene complement(3177144..3177794) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" /label="epsM gene" CDS complement(3177791..3178399) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" /EC_number="2.7.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase involved in extracellular matrix synthesis" /protein_id="NP_391305.1" /db_xref="EnsemblGenomes-Gn:BSU34250" /db_xref="EnsemblGenomes-Tr:CAB15430" /db_xref="GOA:P71062" /db_xref="InterPro:IPR003362" /db_xref="SubtiList:BG11871" /db_xref="UniProtKB/Swiss-Prot:P71062" /translation="MILKRLFDLTAAIFLLCCTSVIILFTIAVVRLKIGSPVFFKQVR PGLHGKPFTLYKFRTMTDERDSKGNLLPDEVRLTKTGRLIRKLSIDELPQLLNVLKGD LSLVGPRPLLMDYLPLYTEKQARRHEVKPGITGWAQINGRNAISWEKKFELDVWYVDN WSFFLDLKILCLTVRKVLVSEGIQQTNHVTAERFTGSGDVSS*" /label="epsL CDS" gene complement(3177791..3178399) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" /label="epsL gene" CDS complement(3178396..3179913) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 15849754, 16850406, 26078454, 27897378; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative extracellular matrix component exporter; putative cyclic di-GMP receptor" /protein_id="YP_003097789.1" /db_xref="EnsemblGenomes-Gn:BSU34265" /db_xref="EnsemblGenomes-Tr:CAX52695" /db_xref="GOA:P71060" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="UniProtKB/Swiss-Prot:P71060" /translation="MKFTINFSANLTAFLLSVFLSVWMTPFIVKTLGVEAFGFVHLTQ NVINYFSVITVALSSVVVRFFSVAAHRGEREKANAYISNYLAASVLISLLLLLPLAGS AFFIDRVMNVPQALLADVRLSILIGSVLFILTFLMAGFGAAPFYANRLYITSSIQAVQ MLIRVLSVLLLFACFAPKIWQIQLAALAGAVIASVLSFYFFKKLIPWFSFRMKDLSFR TSKELFQAGAWSSVNQIGVLLFLQIDLLTANLMLGASASGKYAAIIQFPLLLRSLAGT VASLFAPIMTSYYSKGDMEGLMNYANKAVRLNGLLLALPAALLGGLAGPFLTIWLGPS FSTIAPLLFIHAGYLVVSLAFMPLFYIWTAFNQQKTPAIVTLLLGAVNVVLAVTLSGP AHLGLYGITLAGAISLILKNAIFTPLYVSRITGYKKHVFLKGIIGPLSAAVFAWTVCK AIQFIVKIDSWPSLIATGVTVSFCYAVFAFMLVCTKEERQLVLKRFRKTKGAVNL*" /label="epsK CDS" gene complement(3178396..3179913) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" /label="epsK gene" CDS complement(3179910..3180944) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 26078454, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase involved in biofilm matrix formation" /protein_id="NP_391308.1" /db_xref="EnsemblGenomes-Gn:BSU34280" /db_xref="EnsemblGenomes-Tr:CAB15433" /db_xref="GOA:P71059" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11868" /db_xref="UniProtKB/Swiss-Prot:P71059" /translation="MIPLVSIIVPMYNVEPFIEECIDSLLRQTLSDIEIILVNDGTPD RSGEIAEDYAKRDARIRVIHQANGGLSSARNTGIKAARGTYIGFVDGDDYVSSAMFQR LTEEAEQNQLDIVGCGFYKQSSDRRTYVPPQLEANRVLTKPEMTEQLKHAHETRFIWY VWRYLYRRELFERANLLFDEDIRFAEDSPFNLSAFREAERVKMLDEGLYIYRENPNSL TEIPYKPAMDEHLQKQYQAKIAFYNHYGLAGACKEDLNVYICRHQLPMLLANACASPN SPKDIKKKIRQILSYDMVRQAVRHTPFQHEKLLRGERLVLALCKWRLTFLIKLFFEQR GTMKGSAKQA*" /label="epsJ CDS" gene complement(3179910..3180944) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" /label="epsJ gene" CDS complement(3180941..3182017) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15173185, 15661000, 20720312, 26078454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide pyruvyl transferase involved in biofilm matrix formation" /protein_id="NP_391309.1" /db_xref="EnsemblGenomes-Gn:BSU34290" /db_xref="EnsemblGenomes-Tr:CAB15434" /db_xref="GOA:P71058" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11867" /db_xref="UniProtKB/Swiss-Prot:P71058" /translation="MSLQSLKINFAEWLLLKVKYPSQYWLGAADQPVKAAAHQKKIIL TLLPSHDNLGDHAIAYASKAFLEQEYPDFDIVEVDMKDIYKSAKSLIRSRHPEDMVFI IGGGNMGDLYRYEEWTRRFIIKTFHDYRVVQLPATAHFSDTKKGRKELKRAQKIYNAH PGLLLMARDETTYQFMKQHFQEKTILKQPDMVLYLDRSKAPAEREGVYMCLREDQESV LQEEQRNRVKAALCEEFGEIKSFTTTIGRRVSRDTREHELEALWSKLQSAEAVVTDRL HGMIFCALTGTPCVVIRSFDHKVMEGYQWLKDIPFMKLIEHPEPERVTAAVNELLTKE TSRAGFPRDVYFKGLRDKISGEAQ*" /label="epsI CDS" gene complement(3180941..3182017) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" /label="epsI gene" CDS complement(3182022..3183056) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15083514, 15661000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in biofilmformation" /protein_id="NP_391310.1" /db_xref="EnsemblGenomes-Gn:BSU34300" /db_xref="EnsemblGenomes-Tr:CAB15435" /db_xref="GOA:P71057" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11866" /db_xref="UniProtKB/Swiss-Prot:P71057" /translation="METPAVSLLVAVYNTETYIRTCLESLRNQTMDNIEIIIVNDGSA DASPDIAEEYAKMDNRFKVIHQENQGLGAVRNKGIEAARGEFIAFIDSDDWIEPDYCE QMLRTAGDETDLVICNYAAEFEDTGKTMDSDIAQTYQDQPKEHYIKALFEGKVRGFSW NKLYRRSMIEAHRLSFPLRGELEHVEDQFFSFRAHFFARSVSYVKTPLYHYRIHLSSI VQRYQKKLFESGLALYETNAAFLQENNKLEEYRKELDTFIVLHSSICMLNEWKTSGSR RLFEKLRNVGVICADPVFQESLSKTGTAPFDAKRSCLLLMAKYRMIPFVAMASAVYQR VIEYKMRNRG*" /label="epsH CDS" gene complement(3182022..3183056) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" /label="epsH gene" CDS complement(3183081..3184184) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 15849754, 16850406, 22451411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 15849754, 16850406, 22451411; Product type f: factor" /codon_start=1 /transl_table=11 /product="biofilm extracellular matrix formation chain-length determining factor" /protein_id="NP_391311.1" /db_xref="EnsemblGenomes-Gn:BSU34310" /db_xref="EnsemblGenomes-Tr:CAB15436" /db_xref="GOA:P71056" /db_xref="SubtiList:BG11865" /db_xref="UniProtKB/Swiss-Prot:P71056" /translation="MIVYAVNMGIVFIWSWFAKMCGGRDDSLATGYRPNKLLIWIPLA SLVLVSGLRYRVGTDFQTYTLLYELAGDYQNVWQIFGFGTAKTATDPGFTALLWLMNF ITEDPQIMYFTVAVVTYSFIMKTLADYGRPFELSVFLFLGTFHYYASFNGIRQYMVAA VLFWAIRYIISGNWKRYFLIVLVSSLFHSSALIMIPVYFIVRRKAWSPAIFGLSALFL GMTFLYQKFISVFVVVLENSSYSHYEKWLMTNTNGMNVIKIAVLVLPLFLAFCYKERL RSLWPQIDIVVNLCLLGFLFGLLATKDVIFARFNIYFGLYQMILVPYFVRIFDEKSNA LIYIAIVVCYFLYSYLLMPVDSSVLPYRTIFSR*" /label="epsG CDS" gene complement(3183081..3184184) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" /label="epsG gene" CDS complement(3184181..3185335) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" /EC_number="2.-.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 22451411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in matrix formation (chain-length determination)" /protein_id="NP_391312.1" /db_xref="EnsemblGenomes-Gn:BSU34320" /db_xref="EnsemblGenomes-Tr:CAB15437" /db_xref="GOA:P71055" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11864" /db_xref="UniProtKB/Swiss-Prot:P71055" /translation="MNSSQKRVLHVLSGMNRGGAETMVMNLYRKMDKSKVQFDFLTYR NDPCAYDEEILSLGGRLFYVPSIGQSNPLTFVRNVRNAIKENGPFSAVHAHTDFQTGF IALAARLAGVPVRVCHSHNTSWKTGFNWKDRLQLLVFRRLILANATALCACGEDAGRF LFGQSNMERERVHLLPNGIDLELFAPNGQAADEEKAARGIAADRLIIGHVARFHEVKN HAFLLKLAAHLKERGIRFQLVLAGDGPLCGEIEEEARQQNLLSDVLFLGTEERIHELM RTFDVFVMPSLYEGLPVVLVEAQASGLPCIISDSITEKVDAGLGLVTRLSLSEPISVW AETIARAAAAGRPKREFIKETLAQLGYDAQQNVGALLNVYNISTEKDHNR*" /label="epsF CDS" gene complement(3184181..3185335) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" /label="epsF gene" CDS complement(3185328..3186164) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 21170308, 22720735, 23480406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 21170308, 22720735, 23480406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional flagellar clutch and glycosyltransferase acting during biofilm formation" /protein_id="NP_391313.2" /db_xref="EnsemblGenomes-Gn:BSU34330" /db_xref="EnsemblGenomes-Tr:CAB15438" /db_xref="GOA:P71054" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11863" /db_xref="UniProtKB/Swiss-Prot:P71054" /translation="MNSGPKVSVIMGIYNCERTLAESIESILSQSYKNWELILCDDAS TDGTLRIAKQYAAHYSDRIKLIQNKTNKRLAASLNHCLSHATGDYIARQDGDDLSFPR RLEKQVAFLEKHRHYQVVGTGMLVFDEFGVRGARILPSVPEPGIMAKGTPFCHGTIMM RASAYRTLKGYRSVRRTRRMEDIDLWLRFFEEGFRGYNLQEALYKVREDSDAFKRRSF TYSIDNAILVYQACRRLKLPLSDYIYIAKPLIRAFMPAAVMNRYHKKRVMNQKEGLVK HE*" /label="epsE CDS" gene complement(3185328..3186164) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" /label="epsE gene" CDS complement(3186161..3187306) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512, 26299781; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative extracellular matrix glycosyltransferase" /protein_id="NP_391314.1" /db_xref="EnsemblGenomes-Gn:BSU34340" /db_xref="EnsemblGenomes-Tr:CAB15439" /db_xref="GOA:P71053" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11862" /db_xref="UniProtKB/Swiss-Prot:P71053" /translation="MTKKILFCATVDYHFKAFHLPYFKWFKQMGWEVHVAANGQTKLP YVDEKFSIPIRRSPFDPQNLAVYRQLKKVIDTYEYDIVHCHTPVGGVLARLAARQARR HGTKVLYTAHGFHFCKGAPMKNWLLYYPVEKWLSAYTDCLITINEEDYIRAKGLQRPG GRTQKIHGIGVNTERFRPVSPIEQQRLREKHGFREDDFILVYPAELNLNKNQKQLIEA AALLKEKIPSLRLVFAGEGAMEHTYQTLAEKLGASAHVCFYGFCSDIHELIQLADVSV ASSIREGLGMNVLEGMAAEQPAIATDNRGHREIIRDGENGFLIKIGDSAAFARRIEQL YHKPELCRKLGQEGRKTALRFSEARTVEEMADIYSAYMDMDTKEKSV*" /label="epsD CDS" gene complement(3186161..3187306) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" /label="epsD gene" CDS complement(3187318..3189114) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" /EC_number="5.1.3.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 23378512, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-sugar epimerase involved in biofilmmatrix formation" /protein_id="NP_391315.1" /db_xref="EnsemblGenomes-Gn:BSU34350" /db_xref="EnsemblGenomes-Tr:CAB15440" /db_xref="GOA:P71052" /db_xref="InterPro:IPR003869" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11861" /db_xref="UniProtKB/Swiss-Prot:P71052" /translation="MIIALDTYLVLNSVIAGYQFLKDSYQFYDSGALLLTAVSLLLSY HVCAFLFNQYKQVWTYTGLGELIVLLKGITLSAAVTGVIQYAVYHTMFFRLLTACWVL QLLSIGGTRILSRVLNESIRKKRCASSRALIIGAGSGGTLMVRQLLSKDEPDIIPVAF IDDDQTKHKLEIMGLPVIGGKESIMPAVQKLKINYIIIAIPSLRTHELQVLYKECVRT GVSIKIMPHFDEMLLGTRTAGQIRDVKAEDLLGRKPVTLDTSEISNRIKGKTVLVTGA GGSIGSEICRQISAFQPKEIILLGHGENSIHSIYTELNGRFGKHIVFHTEIADVQDRD KMFTLMKKYEPHVVYHAAAHKHVPLMEHNPEEAVKNNIIGTKNVAEAADMSGTETFVL ISSDKAVNPANVMGATKRFAEMIIMNLGKVSRTKFVAVRFGNVLGSRGSVIPIFKKQI EKGGPVTVTHPAMTRYFMTIPEASRLVIQAGALAKGRQIFVLDMGEPVKIVDLAKNLI HLSGYTTEQVPIEFTGIRPGEKMYEELLNKNEVHAEQIFPKIHIGKAVDGDWPVLMRF IEDFHELPEADLRARLFAAINTSEEMTAASVH*" /label="epsC CDS" gene complement(3187318..3189114) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" /label="epsC gene" S_feature complement(3189115..3189174) /Source="Nicolas_S_feature" /locus_tag="new_3528204_3528263_c" /HighExp="LoTm, G/S, M9-tran, BMM, MG 150, S3, S2, S4, aero, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.79" /TUlongSig="NA" /TUlongPSig="NA" /label="S1312" promotor_-10 complement(3189148..3189166) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3189174) /Source="Nicolas_upshifts" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3189180..3189186) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3189373..3190056) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" /EC_number="2.7.10.2" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 15741737, 24493247, 26283769, 28950882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 15741737, 24493247, 26283769, 28950882; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine kinase involved in biofilm matrix formation" /protein_id="NP_391316.1" /db_xref="EnsemblGenomes-Gn:BSU34360" /db_xref="EnsemblGenomes-Tr:CAB15441" /db_xref="GOA:P71051" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11860" /db_xref="UniProtKB/Swiss-Prot:P71051" /translation="MIFRKKKARRGLAQISVLHNKSVVAEQYRTIRTNIEFSSVQTNL RSILVTSSVPGEGKSFSAANLAAVFAQQQEKKVLLVDADLRKPTINQTFQVDNVTGLT NVLVGNASLSETVQKTPIDNLYVLTSGPTPPNPAELLSSKAMGDLISEIYEQFSLVIF DSPPLLAVADAQILANQTDGSVLVVLSGKTKTDTVLKAKDALEQSNAKLLGALLNKKK MKKSEHYSY*" /label="epsB CDS" gene complement(3189373..3190056) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" /label="epsB gene" CDS complement(3190062..3190766) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12970183, 15661000, 23378512, 26283769, 28950882; Product type r : regulator" /codon_start=1 /transl_table=11 /product="modulator of protein tyrosine kinase EpsB involved in biofilm matrix formation" /protein_id="NP_391317.1" /db_xref="EnsemblGenomes-Gn:BSU34370" /db_xref="EnsemblGenomes-Tr:CAB15442" /db_xref="GOA:P71050" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG11859" /db_xref="UniProtKB/Swiss-Prot:P71050" /translation="MNENMSFKELYAIVRHRFVLILLITIGVTLIMGFVQFKVISPTY QASTQVLVHESDGEENSNLSDIQRNLQYSSTFQSIMKSTALMEEVKAELHLSESASSL KGKVVTSSENESEIINVAVQDHDPAKAAEIANTLVNKFEKEVDERMNVQGVHILSEAK ASESPMIKPARLRNMVMAFGAAVMGGITLAFFLHFLDDTCKSARQLSERTGLPCLGSV PDVHKGRNRGIKHFGE*" /label="epsA CDS" gene complement(3190062..3190766) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" /label="epsA gene" upshifts 3190748 /Source="Nicolas_upshifts" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3190751..3190769 /Source="Nicolas_upshift_promotors" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3190767..3190824) /Source="Nicolas_S_feature" /locus_tag="new_3529856_3529913_c" /HighExp="LoTm, BT, S3, G/S, BMM, M9-tran, S4, aero, T1.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.952" /TUlongSig="NA" /TUlongPSig="NA" /label="S1313" promotor_-10 complement(3190820..3190839) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3190825) /Source="Nicolas_upshifts" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3190853..3190860) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3190942..3190947 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-35" promotor_-10 3190962..3190981 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-10" upshifts 3190968 /Source="Nicolas_upshifts" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="upshifts" CDS 3191012..3191470 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" /function="16.5: Explore" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18430133, 18647168, 20923420, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18430133, 18647168, 20923420, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of autolysin genes (biofilm formation)" /protein_id="NP_391318.1" /db_xref="EnsemblGenomes-Gn:BSU34380" /db_xref="EnsemblGenomes-Tr:CAB15443" /db_xref="GOA:P71049" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="SubtiList:BG11858" /db_xref="UniProtKB/Swiss-Prot:P71049" /translation="MIGRIIRLYRKRKGYSINQLAVESGVSKSYLSKIERGVHTNPSV QFLKKVSATLEVELTELFDAETMMYEKISGGEEEWRVHLVQAVQAGMEKEELFTFTNR LKKEQPETASYRNRKLTESNIEEWKALMAEAREIGLSVHEVKSFLKTKGR*" /label="slrR CDS" gene 3191012..3191470 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" /label="slrR gene" promotor_-35 3191492..3191495 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3191501 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3191512..3191530 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3191546..3193015 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" /label="pnbA CDS" gene 3191546..3193015 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /label="pnbA gene" downshifts 3192992 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS 3193018..3193209 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" /label="hypothetical protein CDS" gene 3193018..3193209 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /label="gene" downshifts 3193188 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(3193236..3193721) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" /label="padC CDS" gene complement(3193236..3193721) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /label="padC gene" CDS complement(3193744..3194055) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" /label="yveG CDS" gene complement(3193744..3194055) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo /label="yveG gene" CDS complement(3194107..3194199) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" /label="yveF CDS" gene complement(3194107..3194199) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo /label="yveF gene" promotor_-10 complement(3194239..3194258) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3194256) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3194272..3194279) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3194330..3195013) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" /label="racX CDS" gene complement(3194330..3195013) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /label="racX gene" downshifts complement(3194348) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" /label="downshifts" CDS complement(3195029..3196384) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" /label="pbpE CDS" gene complement(3195029..3196384) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /label="pbpE gene" promotor_-10 complement(3196396..3196411) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3196412) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3196423..3196432) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3196686..3196693 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3196707..3196726 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3196710 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="upshifts" S_feature 3196732..3196922 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 3196923..3198344 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" /label="sacB CDS" gene 3196923..3198344 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /label="sacB gene" downshifts 3198338 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3198418..3199968 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" /label="levB CDS" gene 3198418..3199968 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /label="levB gene" promotor_-35 3200012..3200018 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3200032..3200043 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3200032 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="upshifts" CDS 3200076..3201638 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" /label="aspP CDS" gene 3200076..3201638 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /label="aspP gene" downshifts 3201616 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3201628..3202317 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" /label="yvdT CDS" gene 3201628..3202317 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /label="yvdT gene" promotor_-35 3201667..3201674 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3201688..3201707 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3201697 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="upshifts" downshifts 3202298 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(3202396) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS 3202399..3202734 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" /label="psmA CDS" gene 3202399..3202734 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /label="psmA gene" CDS 3202734..3203054 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" /label="psmB CDS" gene 3202734..3203054 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /label="psmB gene" S_feature 3203055..3203245 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(3203090..3203602) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" /label="yvdQ CDS" gene complement(3203090..3203602) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /label="yvdQ gene" downshifts 3203222 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3203638..3203649) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3203644) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3203664..3203670) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3203717..3203853) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(3203760) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" CDS complement(3203854..3205197) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" /label="cotNP CDS" gene complement(3203854..3205197) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /label="cotNP gene" promotor_-10 complement(3205226..3205245) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3205234) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3205258..3205267) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3205259..3205264 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3205280..3205298 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3205283 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3205492..3205501 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3205510 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3205515..3205534 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3205553..3206515 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" /label="cotR CDS" gene 3205553..3206515 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /label="cotR gene" S_feature 3206516..3206769 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(3206796) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" tRNA complement(3206800..3206875) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnQ-Arg tRNA" gene complement(3206800..3206875) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /label="trnQ-Arg gene" promotor_-10 complement(3206902..3206921) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3206923) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3206937..3206940) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3207006..3207012 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3207022..3207097 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 3207022 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3207027..3207046 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3207074..3207081 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3207095..3207114 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3207099 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="upshifts" CDS 3207145..3207738 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" /label="clpP CDS" gene 3207145..3207738 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /label="clpP gene" downshifts 3207727 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 3207772..3208170 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(3207784..3208464) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" /label="mdxM CDS" gene complement(3207784..3208464) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /label="mdxM gene" downshifts complement(3207808) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" CDS complement(3208461..3210146) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" /label="mdxL CDS" gene complement(3208461..3210146) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /label="mdxL gene" CDS complement(3210139..3212412) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" /label="mdxK CDS" gene complement(3210139..3212412) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /label="mdxK gene" CDS complement(3212390..3213274) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" /label="mdxJ CDS" gene complement(3212390..3213274) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /label="mdxJ gene" CDS complement(3213280..3214116) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" /label="mdxG CDS" gene complement(3213280..3214116) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /label="mdxG gene" CDS complement(3214117..3215424) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" /label="mdxF CDS" gene complement(3214117..3215424) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /label="mdxF gene" promotor_-35 3214482..3214491 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3214504..3214523 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3214508 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3215464..3216717) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" /label="mdxE CDS" gene complement(3215464..3216717) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /label="mdxE gene" S_feature complement(3216718..3216812) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(3216813..3218582) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" /label="mdxD CDS" gene complement(3216813..3218582) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /label="mdxD gene" promotor_-35 3218503..3218508 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3218524..3218542 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3218534 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3218620..3218639) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3218633) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3218652..3218659) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3218695..3219645) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" /label="mdxR CDS" gene complement(3218695..3219645) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /label="mdxR gene" promotor_-10 complement(3219660..3219678) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3219673) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3219690..3219698) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3219779) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3219851..3220426) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" /label="yvdD CDS" gene complement(3219851..3220426) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /label="yvdD gene" downshifts complement(3219863) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3220469..3220488) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3220475..3220482 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3220485) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="upshifts" upshifts 3220492 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3220495..3220514 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3220503..3220510) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3220543..3220863 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" /label="yvdC CDS" gene 3220543..3220863 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /label="yvdC gene" downshifts 3220844 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3220890) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(3220890..3222482) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" /label="yvdB CDS" gene complement(3220890..3222482) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /label="yvdB gene" CDS complement(3222501..3223094) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" /label="yvdA CDS" gene complement(3222501..3223094) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /label="yvdA gene" promotor_-10 complement(3223136..3223155) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3223149) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3223170..3223174) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3223220..3223225 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3223241..3223259 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3223242 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3223415..3223422 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3223436..3223455 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3223440 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" CDS 3223477..3224454 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" /label="yvcT CDS" gene 3223477..3224454 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /label="yvcT gene" downshifts 3224426 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3224492..3226432) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" /label="psdB CDS" gene complement(3224492..3226432) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /label="psdB gene" downshifts complement(3224516) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" /label="downshifts" CDS complement(3226407..3227186) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" /label="psdA CDS" gene complement(3226407..3227186) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /label="psdA gene" S_feature complement(3227187..3227268) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(3227269..3228339) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" /label="psdS CDS" gene complement(3227269..3228339) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /label="psdS gene" CDS complement(3228333..3229046) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" /label="psdR CDS" gene complement(3228333..3229046) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /label="psdR gene" promotor_-10 complement(3229092..3229111) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3229104) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3229106..3229367) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(3229124..3229127) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3229127..3229134 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3229145..3229164 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3229150 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3229193..3229402 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" /label="yvzJ CDS" gene 3229193..3229402 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /label="yvzJ gene" downshifts 3229380 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3229412) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3229438..3230202) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" /label="yvcN CDS" gene complement(3229438..3230202) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /label="yvcN gene" downshifts complement(3229460) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3230203..3230460) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" /label="crh CDS" gene complement(3230203..3230460) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /label="crh gene" CDS complement(3230484..3231434) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" /label="whiA CDS" gene complement(3230484..3231434) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /label="whiA gene" CDS complement(3231457..3232410) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" /label="mgfK CDS" gene complement(3231457..3232410) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /label="mgfK gene" CDS complement(3232412..3233299) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" /label="yvcJ CDS" gene complement(3232412..3233299) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /label="yvcJ gene" CDS complement(3233324..3233800) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" /label="yvcI CDS" gene complement(3233324..3233800) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /label="yvcI gene" promotor_-10 complement(3233820..3233839) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3233834) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3233855..3233859) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3233878..3233897) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3233891) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3233912..3233915) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3233967..3234117) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(3234010) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" /label="downshifts" CDS complement(3234118..3235068) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" /label="trxB CDS" gene complement(3234118..3235068) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /label="trxB gene" S_feature complement(3235069..3235156) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(3235145..3235164) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3235156) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3235158..3235249) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(3235179..3235182) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3235197..3235203 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3235217..3235235 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3235231 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="upshifts" S_feature 3235232..3238618 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(3235274..3236695) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" /label="cwlO CDS" gene complement(3235274..3236695) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /label="cwlO gene" downshifts complement(3235294) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" /label="downshifts" downshifts complement(3235418) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" misc_feature 3236322..3236326 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3236332 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3236611..3236615 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3236618 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3236696..3236893) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 3236816 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3236881..3236900) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(3236893) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" promotor_-35 complement(3236912..3236919) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(3237076..3238530) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" /label="yvcD CDS" gene complement(3237076..3238530) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /label="yvcD gene" downshifts complement(3237096) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" S_feature complement(3238531..3238655) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 3238576 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3238656..3240425) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" /label="bmrA CDS" gene complement(3238656..3240425) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /label="bmrA gene" S_feature complement(3240426..3240500) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(3240489..3240508) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3240500) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" CDS complement(3240590..3240949) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" /label="yvzA CDS" gene complement(3240590..3240949) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /label="yvzA gene" downshifts complement(3240610) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3240964..3242874) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" /label="yvcB CDS" gene complement(3240964..3242874) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /label="yvcB gene" CDS complement(3242876..3243601) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /translation="MKKIIFICFSLLLALTGGCSMNDNDKNSTNDNKTEAVKPKDMDP KDLPQVPAFQDEKTREYMVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGK NKESIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKK TDIYTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDE EKAKNKVEKLINSITFLIDKKEK*" /label="yvcA CDS" gene complement(3242876..3243601) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /label="yvcA gene" S_feature complement(3243602..3243690) /Source="Nicolas_S_feature" /locus_tag="new_3582691_3582779_c" /HighExp="T1.30H, T0.30H, T1.0H, T2.0H, T2.30H, T3.0H, T-1.40H, T-1.10H, MG 150, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1330" promotor_-10 complement(3243690..3243709) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3243690) /Source="Nicolas_upshifts" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3243692..3243821) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" promotor_-35 complement(3243725..3243728) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3243847..3244476) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" /label="hisIE CDS" gene complement(3243847..3244476) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /label="hisIE gene" downshifts complement(3243866) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" /label="downshifts" CDS complement(3244473..3245231) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" /label="hisF CDS" gene complement(3244473..3245231) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /label="hisF gene" CDS complement(3245228..3245965) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" /label="hisA CDS" gene complement(3245228..3245965) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /label="hisA gene" CDS complement(3245962..3246600) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" /label="hisH CDS" gene complement(3245962..3246600) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /label="hisH gene" promotor_no_box 3246458..3246558 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3246518 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3246601..3247185) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" /label="hisB CDS" gene complement(3246601..3247185) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /label="hisB gene" CDS complement(3247182..3248465) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" /label="hisD CDS" gene complement(3247182..3248465) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /label="hisD gene" CDS complement(3248462..3249103) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" /label="hisG CDS" gene complement(3248462..3249103) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /label="hisG gene" CDS complement(3249096..3250271) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " /label="hisZ CDS" gene complement(3249096..3250271) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /label="hisZ gene" S_feature complement(3250272..3250349) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 3250315..3250321 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3250333..3250352 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3250333..3250352) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3250346 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3250349) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3250365..3250372) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3250481..3250500 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3250488 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="upshifts" CDS 3250522..3251274 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" /label="yvpB CDS" gene 3250522..3251274 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /label="yvpB gene" S_feature 3251275..3251513 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(3251296..3251307) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3251302) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3251322..3251328) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3251514..3252179 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" /label="pelC CDS" gene 3251514..3252179 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /label="pelC gene" downshifts 3252150 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(3252199..3252717) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" /label="hprF CDS" gene complement(3252199..3252717) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /label="hprF gene" downshifts complement(3252233) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3252721..3253371) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" /label="ppaX CDS" gene complement(3252721..3253371) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /label="ppaX gene" CDS complement(3253368..3254306) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" /label="yvoD CDS" gene complement(3253368..3254306) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /label="yvoD gene" CDS complement(3254330..3255139) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" /label="lgt CDS" gene complement(3254330..3255139) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /label="lgt gene" CDS complement(3255153..3256085) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" /label="hprK CDS" gene complement(3255153..3256085) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /label="hprK gene" promotor_-10 complement(3256127..3256146) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3256133) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3256162..3256167) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3256202..3256209 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3256221 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3256224..3256241 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3256267..3257457 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" /label="nagA CDS" gene 3256267..3257457 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /label="nagA gene" promotor_-35 3257255..3257261 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3257276 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3257277..3257295 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3257454..3258182 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" /label="nagBA CDS" gene 3257454..3258182 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /label="nagBA gene" CDS 3258200..3258931 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" /label="nagR CDS" gene 3258200..3258931 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /label="nagR gene" CDS complement(3258951..3262820) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" /label="yvnB CDS" gene complement(3258951..3262820) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /label="yvnB gene" downshifts complement(3259073) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3262840..3262851) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3262847) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3262866..3262872) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3262910..3262916 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3262930..3262949 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3262935 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="upshifts" CDS 3262985..3263458 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" /label="yvnA CDS" gene 3262985..3263458 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /label="yvnA gene" S_feature 3263459..3263566 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(3263499..3264716) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" /label="cypX CDS" gene complement(3263499..3264716) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /label="cypX gene" downshifts complement(3263512) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3263538..3263543 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3263558..3263569 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3263568..3263853 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 3263568 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="upshifts" downshifts 3263810 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3264732..3265478) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" /label="pchC CDS" gene complement(3264732..3265478) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /label="pchC gene" S_feature complement(3265479..3265665) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(3265651..3265670) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3265665) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3265684..3265691) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3265799..3265806 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3265821..3265840 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3265833 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="upshifts" S_feature 3265834..3265903 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 3265904..3266413 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" /label="pchR CDS" gene 3265904..3266413 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /label="pchR gene" S_feature complement(3266309..3267647) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(3266350) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3266434..3267645 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" /label="pchE CDS" gene 3266434..3267645 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /label="pchE gene" downshifts 3267643 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" /label="downshifts" CDS complement(3267673..3268032) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" /label="yvlD CDS" gene complement(3267673..3268032) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /label="yvlD gene" S_feature 3267688..3268404 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(3267692) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3268034..3268231) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" /label="yvlC CDS" gene complement(3268034..3268231) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /label="yvlC gene" CDS complement(3268236..3269333) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" /label="yvlB CDS" gene complement(3268236..3269333) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /label="yvlB gene" CDS complement(3269358..3269684) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" /label="yvlA CDS" gene complement(3269358..3269684) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /label="yvlA gene" promotor_-10 complement(3269737..3269752) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3269752) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3269754..3270244) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(3269764..3269773) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3269832..3269835 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3269850..3269869 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3269860 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="upshifts" CDS 3269902..3270132 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" /label="yvkN CDS" gene 3269902..3270132 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /label="yvkN gene" promotor_-10 complement(3270235..3270254) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(3270245) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="upshifts" promotor_-35 complement(3270270..3270274) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(3270331..3270813) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" /label="yvzB CDS" gene complement(3270331..3270813) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo /label="yvzB gene" downshifts 3270339 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" /label="downshifts" downshifts complement(3270354) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3270486) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3270494..3270497) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3270574..3270578) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3270574) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3270594..3270597) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3270814..3270947) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(3270975..3273848) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" /label="uvrA CDS" gene complement(3270975..3273848) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /label="uvrA gene" downshifts complement(3270992) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3273856..3275841) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" /label="uvrB CDS" gene complement(3273856..3275841) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /label="uvrB gene" promotor_-10 complement(3275875..3275894) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3275887) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3275889..3275974) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(3275906..3275913) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3276019) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" /label="downshifts" CDS complement(3276027..3276257) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" /label="csbA CDS" gene complement(3276027..3276257) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /label="csbA gene" promotor_-10 complement(3276284..3276303) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(3276294) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="upshifts" S_feature complement(3276296..3276360) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(3276317..3276324) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(3276337..3276355) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3276358) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3276370..3276376) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3276426) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(3276452..3276552) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3276492) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3276574..3276581 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3276595..3276614 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3276612 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3276704..3279199 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" /label="yvkC CDS" gene 3276704..3279199 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /label="yvkC gene" misc_feature 3279214..3279218 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3279232 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="upshifts" CDS 3279275..3279844 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" /label="yvkB CDS" gene 3279275..3279844 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /label="yvkB gene" CDS 3279875..3281209 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" /label="yvkA CDS" gene 3279875..3281209 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /label="yvkA gene" downshifts 3281190 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" /label="downshifts" CDS complement(3281257..3282450) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" /label="minJ CDS" gene complement(3281257..3282450) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /label="minJ gene" downshifts complement(3281266) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" /label="downshifts" downshifts complement(3281331) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(3282451..3282528) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(3282454) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(3282529..3282867) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" /label="swrAAc CDS" gene complement(3282529..3282867) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo /label="swrAAc gene" CDS complement(3282842..3282958) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" /label="swrAAn CDS" gene complement(3282842..3282958) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo /label="swrAAn gene" S_feature complement(3282959..3283048) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(3283030..3283048) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3283048) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3283050..3283130) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(3283062..3283067) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3283116..3283134) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3283130) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3283148..3283155) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3283267..3284709) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" /label="ctpB CDS" gene complement(3283267..3284709) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /label="ctpB gene" downshifts complement(3283356) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3284755..3284766) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3284766) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3284781..3284787) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3284849..3285739) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" /label="ftsX CDS" gene complement(3284849..3285739) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /label="ftsX gene" downshifts complement(3284866) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" /label="downshifts" CDS complement(3285732..3286418) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" /label="ftsE CDS" gene complement(3285732..3286418) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /label="ftsE gene" S_feature complement(3286419..3286551) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(3286541..3286560) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3286551) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3286575..3286578) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3286652..3286990) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" /label="cccB CDS" gene complement(3286652..3286990) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /label="cccB gene" downshifts complement(3286653) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3287017..3287036) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3287030) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" CDS complement(3287039..3287923) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" /label="yvjA CDS" gene complement(3287039..3287923) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /label="yvjA gene" promotor_-35 complement(3287050..3287057) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(3287911..3287930) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3287932) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" promotor_-35 complement(3287945..3287952) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(3289080..3289151), complement(3288050..3289078)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" /label="prfB CDS" gene complement(3288050..3289151) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /label="prfB gene" downshifts complement(3288066) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(3289152..3289220) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(3289221..3291746) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" /label="secA CDS" gene complement(3289221..3291746) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /label="secA gene" S_feature complement(3291747..3291827) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(3291817..3291836) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3291827) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3291914..3292483) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" /label="hpf CDS" gene complement(3291914..3292483) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /label="hpf gene" downshifts complement(3291922) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 3292450..3292456 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3292469..3292488 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3292476 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3292510..3292528) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3292518) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3292520..3292640) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(3292540..3292548) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3292624..3292642) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3292640) /Source="Nicolas_upshifts" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3292658..3292663) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3292674..3293051) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097791.1" /db_xref="EnsemblGenomes-Gn:BSU35319" /db_xref="EnsemblGenomes-Tr:CAX52698" /db_xref="UniProtKB/Swiss-Prot:C0H3R9" /translation="MKSIEDYTLLSAYYHLLFTIEEGLCYLIEAEENLSKTEGDRIYQ DLIQAFFYLDSTHSTLLFIMDSRCAEICVKAFDQIFAEFDQLVSFSFPSHEFCEYLKE HFLIHYRKWMLSIHQCMEPFLIN*" /label="yvzG CDS" gene complement(3292674..3293051) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /label="yvzG gene" CDS complement(3293061..3293402) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16952964; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliT involved in control of flagella expression" /protein_id="NP_391412.1" /db_xref="EnsemblGenomes-Gn:BSU35320" /db_xref="EnsemblGenomes-Tr:CAB15549" /db_xref="GOA:P39740" /db_xref="SubtiList:BG10923" /db_xref="UniProtKB/Swiss-Prot:P39740" /translation="MNNIDQLYTETKSMLSHIQNTPESDELLKQIEDFVATRSELIQE ISLPLSEEERKQMKLILTWDQLIVKEMERLKQSIATELQQMKRKRVMHTTYLNPYNNI TIDGTYYDKRK*" /label="fliT CDS" gene complement(3293061..3293402) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /label="fliT gene" CDS complement(3293399..3293800) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16806204, 16936039, 20534509, 23144244, 23874669; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliS" /protein_id="NP_391413.1" /db_xref="EnsemblGenomes-Gn:BSU35330" /db_xref="EnsemblGenomes-Tr:CAB15550" /db_xref="GOA:P39739" /db_xref="InterPro:IPR003713" /db_xref="InterPro:IPR036584" /db_xref="PDB:1VH6" /db_xref="SubtiList:BG10922" /db_xref="UniProtKB/Swiss-Prot:P39739" /translation="MAIQNPYTAYQQNSVNTATPGELTLMLYNGCLKFIRLAAQAIEN DDMERKNENLIKAQNIIQELNFTLNRNIELSASMGAMYDYMYRRLVQANIKNDTGMLA EVEGYVTDFRDAWKQAIQSERKDRHGSGGIA*" /label="fliS CDS" gene complement(3293399..3293800) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /label="fliS gene" CDS complement(3293822..3295318) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9648743, 12354229, 24296669, 25355936; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-associated capping protein 2 (HAP2)" /protein_id="NP_391414.1" /db_xref="EnsemblGenomes-Gn:BSU35340" /db_xref="EnsemblGenomes-Tr:CAB15551" /db_xref="GOA:P39738" /db_xref="InterPro:IPR003481" /db_xref="InterPro:IPR010809" /db_xref="InterPro:IPR010810" /db_xref="SubtiList:BG10921" /db_xref="UniProtKB/Swiss-Prot:P39738" /translation="MVTRITGLASGMDIDDIVSKLMQTERAPLDKLTQKKQTLEWQRD SYREVNSKIKELQDYMSKNTLTYPSTYQSKTVTSSNESVLTATGSVSAPNSSSTVEVA SLATAATYKANNYTGYTQGDYNLAFNVVAPGETTAKTVNISVTSADTIDNVISKLNSS DLGVSAFKDKIWNGTEYVETIAFSSKATGAGGSIQAADSATADFMSGQLGFSLDADNK LTAYKEGTNAKVTINGFEMEKLTNNFTVNGVTYSIKNTTAATGPVTTSVSTDVDGIYN QIKEFVDKYNELVDSLNEKLKEEKYRDYTPLTSEQKEAMSDKEVELWEEKAKSGLLRN DSSISTGTNQMRTDFYTQVNADGKTYQLTEFGITTSSAYQLRGHLEINEEKLKAKIAE DPQGVANLFTSGTNDSNYSDKGIMKRITNTLRSTVKSIEAKAGNSTMGASSYSIGKNL NSISTEITDMQDRLNTIENRYYSKFSAMDSAIQKMNEQASYLSQLLVQ*" /label="fliD CDS" gene complement(3293822..3295318) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /label="fliD gene" CDS complement(3295336..3295665) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 19455708; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative flagellar protein of unknown function" /protein_id="NP_391415.1" /db_xref="EnsemblGenomes-Gn:BSU35350" /db_xref="EnsemblGenomes-Tr:CAB15552" /db_xref="InterPro:IPR005186" /db_xref="InterPro:IPR035924" /db_xref="PDB:2HC5" /db_xref="SubtiList:BG10920" /db_xref="UniProtKB/Swiss-Prot:P39737" /translation="MNIERLTTLQPVWDRYDTQIHNQKDNDNEVPVHQVSYTNLAEMV GEMNKLLEPSQVHLKFELHDKLNEYYVKVIEDSTNEVIREIPPKRWLDFYAAMTEFLG LFVDEKK*" /label="yvyC CDS" gene complement(3295336..3295665) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /label="yvyC gene" downshifts 3295662 /Source="Nicolas_upshifts" /id="D1831" /incds=0 /nref=33 /ntot=140 /MaxReadThrough="2.74277" /MaxDrop="4.24086" /score="8.30527041" /energy="-10.1" /TU="NA" /idTUdmin="U2774" /TUdmin="-3062" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3295687..3295705) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3295702) /Source="Nicolas_upshifts" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3295704..3295808) /Source="Nicolas_S_feature" /locus_tag="new_3634793_3634897_c" /HighExp="Lbstat, Cold, Gly, S0, Glu, Pyr, M/G, M0t90, C30, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1351" promotor_-35 complement(3295719..3295726) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3295797..3295816) /Source="Nicolas_upshift_promotors" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3295808) /Source="Nicolas_upshifts" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="upshifts" CDS complement(3295898..3296812) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellin protein" /protein_id="NP_391416.1" /db_xref="EnsemblGenomes-Gn:BSU35360" /db_xref="EnsemblGenomes-Tr:CAB15553" /db_xref="GOA:P02968" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR001492" /db_xref="SubtiList:BG10655" /db_xref="UniProtKB/Swiss-Prot:P02968" /translation="MRINHNIAALNTLNRLSSNNSASQKNMEKLSSGLRINRAGDDAA GLAISEKMRGQIRGLEMASKNSQDGISLIQTAEGALTETHAILQRVRELVVQAGNTGT QDKATDLQSIQDEISALTDEIDGISNRTEFNGKKLLDGTYKVDTATPANQKNLVFQIG ANATQQISVNIEDMGADALGIKEADGSIAALHSVNDLDVTKFADNAADTADIGFDAQL KVVDEAINQVSSQRAKLGAVQNRLEHTINNLSASGENLTAAESRIRDVDMAKEMSEFT KNNILSQASQAMLAQANQQPQNVLQLLR*" /label="hag CDS" gene complement(3295898..3296812) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /label="hag gene" downshifts complement(3295918) /Source="Nicolas_upshifts" /id="D1832" /incds=0 /nref=165 /ntot=233 /MaxReadThrough="5.58531" /MaxDrop="7.10921" /score="11.6997504" /energy="-13.1" /TU="U2773" /idTUdmin="U2775" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature complement(3296813..3296921) /Source="Nicolas_S_feature" /locus_tag="new_3635902_3636010_c" /HighExp="T2.0H, Glucon, M0t90, T2.30H, GM 15, T-0.40H, GM 10, T1.0H, T-1.10H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1352" promotor_-35 3296879..3296880 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3296889..3296903 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3296898 /Source="Nicolas_upshifts" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3296900..3296918) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-10" upshifts complement(3296921) /Source="Nicolas_upshifts" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="upshifts" promotor_-35 complement(3296931..3296938) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-35" CDS complement(3296957..3297181) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8982093, 17555441, 21895793, 23144244, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8982093, 17555441, 21895793, 23144244, 27516547; Product type r: regulator" /codon_start=1 /transl_table=11 /product="carbon storage regulator" /protein_id="NP_391417.1" /db_xref="EnsemblGenomes-Gn:BSU35370" /db_xref="EnsemblGenomes-Tr:CAB15554" /db_xref="GOA:P33911" /db_xref="InterPro:IPR003751" /db_xref="InterPro:IPR036107" /db_xref="PDB:1T3O" /db_xref="SubtiList:BG10654" /db_xref="UniProtKB/Swiss-Prot:P33911" /translation="MLVLSRKINEAIQIGADIEVKVIAVEGDQVKLGIDAPKHIDIHR KEIYLTIQEENNRAAALSSDVISALSSQKK*" /label="csrA CDS" gene complement(3296957..3297181) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /label="csrA gene" downshifts complement(3296996) /Source="Nicolas_upshifts" /id="D1833" /incds=0 /nref=22 /ntot=171 /MaxReadThrough="2.28652" /MaxDrop="3.46262" /score="31.5820557" /energy="-9.2" /TU="NA" /idTUdmin="U2775" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3297175..3297606) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15033535, 16936039, 21895793, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15033535, 16936039, 21895793, 27516547; Product type f: factor" /codon_start=1 /transl_table=11 /product="assembly factor of the flagellum" /protein_id="NP_391418.1" /db_xref="EnsemblGenomes-Gn:BSU35380" /db_xref="EnsemblGenomes-Tr:CAB15555" /db_xref="GOA:P96503" /db_xref="InterPro:IPR003775" /db_xref="InterPro:IPR024046" /db_xref="SubtiList:BG12451" /db_xref="UniProtKB/Swiss-Prot:P96503" /translation="MIIHTKYHGQMNIKEEQIILFESGIPGFLEEKQFVILPLSEDSP FVALQSVTSENLAFIVVSPFIFFKNYEFDLDESTAELLDIDNIQDVEVMTILTMAEPF EKSTANLLAPIIVNRKNMMAKQVVLHDSSYTTKHPIGGESC*" /label="fliW CDS" gene complement(3297175..3297606) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /label="fliW gene" CDS complement(3297627..3298202) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391419.1" /db_xref="EnsemblGenomes-Gn:BSU35390" /db_xref="EnsemblGenomes-Tr:CAB15556" /db_xref="SubtiList:BG12450" /db_xref="UniProtKB/Swiss-Prot:P96502" /translation="MQIPRLIMHSVQGKIGLTTTPASLKMEQPQADLEIEQPSAEMEI SVTPGKLTIDQTQAWEELDRKHVFKRIEEAAQQGHEDVMEGIARTAEEGDELMKIENK GNPIASQARRNSEMHQIQLGENYAPSLSRVKIQYTPSQLDVQITPRKPVIQAEPHKPI VEYTPGNVKVDMLQYPDLNIDVEYPKESPEK*" /label="yviE CDS" gene complement(3297627..3298202) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /label="yviE gene" CDS complement(3298249..3299145) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction protein" /protein_id="NP_391420.1" /db_xref="EnsemblGenomes-Gn:BSU35400" /db_xref="EnsemblGenomes-Tr:CAB15557" /db_xref="GOA:P96501" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR013384" /db_xref="SubtiList:BG11936" /db_xref="UniProtKB/Swiss-Prot:P96501" /translation="MRVTQGMIQQNSLRYIGSSYSKLDKLQSQISSGKKISKASDDPV VAMKSLKYNTQLSQVQQYKSNASQAFTWLENTETNITEGIDILSKVRELAVEAQNDTN GEPERQAIGVEVKQLKEQLLNIANTQVNGRYIFNGTNSDKPPVTDNGDGTYTISDTAD VVVNISNNMSLKVNSDPKSAFGGTSESGQNVFEMLDSFEKALNSGSLDGMDSVLNDID HFSDGMSAERSDLGARYNRLELVNTRLSAQEETATKVLSDNEDVELEEVITEFIAQQS VHRATLAVNAQIVQPTLIDFLK*" /label="flgL CDS" gene complement(3298249..3299145) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /label="flgL gene" downshifts complement(3298272) /Source="Nicolas_upshifts" /id="D1834" /incds=0 /nref=112 /ntot=251 /MaxReadThrough="5.50861" /MaxDrop="3.8234" /score="0.376587888" /energy="-4.8" /TU="U2775,U2776,U2777" /idTUdmin="U2777" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" misc_feature 3298561..3298564 /Source="Nicolas_upshift_promotors" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3298570 /Source="Nicolas_upshifts" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3299156..3300679) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction" /protein_id="NP_391421.1" /db_xref="EnsemblGenomes-Gn:BSU35410" /db_xref="EnsemblGenomes-Tr:CAB15558" /db_xref="GOA:P39810" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR002371" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10401" /db_xref="UniProtKB/Swiss-Prot:P39810" /translation="MTSTFMGLETARRALSAQQAALSTTANNVANANTDGYTRQRVSL EATDYFPAVSKNAEKTAGQMGTGVQGKSVERIRDIFLDYQYRLQNNSAGYYDTKAKAL SQMEGVLNETDDSGLNSVLNSFWNSLQELSNNTNEESARSVVARKGQAVAETFNYISE SLTNVQSNLKAELNTTVLDVNSLLSQLNSLNKQIAQVEPVGLLPNGLYDQRDLLIDKL SSMVDIKVSYNKSGGNALASAEGTVSIEILDKNKQSLGTVLDGKNYEVSELAANYDNE TGLVSSISIGDTAVQAESFSSKGSLLGFIESYGYITADGQEKGVYPEMLSDLDNMALE FAKAFNEVHRNGVTKSGEQGGDFFDFTGGETEPAKGAAGKIKVADSIIDSKGANIAFS LTGAANDNANATKLANVLTGKITINGKETSVLDYYAGLIGELGIEAQEANRLASNTET QLNDADINRQQMSAVSLDEEMTNMIQFQHAYNAAARMVTLQDELLDKVINGMGVGGR* " /label="flgK CDS" gene complement(3299156..3300679) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /label="flgK gene" CDS complement(3300698..3301180) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" /label="flgN CDS" gene complement(3300698..3301180) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /label="flgN gene" CDS complement(3301196..3301462) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" /label="flgM CDS" gene complement(3301196..3301462) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /label="flgM gene" S_feature complement(3301463..3301542) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(3301543..3301962) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" /label="yvyF CDS" gene complement(3301543..3301962) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /label="yvyF gene" promotor_-10 complement(3302001..3302019) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3302012) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3302033..3302040) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3302036..3302758) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" /label="comFC CDS" gene complement(3302036..3302758) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /label="comFC gene" CDS complement(3302722..3303018) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" /label="comFB CDS" gene complement(3302722..3303018) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /label="comFB gene" promotor_-10 complement(3303044..3303063) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3303057) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3303074..3303081) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3303078..3304469) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" /label="comFA CDS" gene complement(3303078..3304469) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /label="comFA gene" promotor_-10 complement(3304483..3304502) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3304498) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3304516..3304523) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3304575..3305420) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" /label="fakBA CDS" gene complement(3304575..3305420) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /label="fakBA gene" downshifts complement(3304586) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3304837..3304844 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3304858..3304877 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3304868..3306600 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3304868 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3305447..3305466) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3305466) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3305481..3305484) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3305518..3306207) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" /label="degU CDS" gene complement(3305518..3306207) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /label="degU gene" downshifts complement(3305532) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature complement(3306208..3306289) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3306290..3307447) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" /label="degS CDS" gene complement(3306290..3307447) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /label="degS gene" S_feature complement(3307448..3307575) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3307495..3307498 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3307513..3307532 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3307524..3307610 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3307524 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3307569..3307588) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3307575) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3307592..3307600 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3307599..3307606) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3307612 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3307614..3307622 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3307664..3308317 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " /label="yvyE CDS" gene 3307664..3308317 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /label="yvyE gene" S_feature complement(3308020..3308612) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3308317..3309492 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " /label="tagV CDS" gene 3308317..3309492 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /label="tagV gene" promotor_-10 complement(3308608..3308626) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3308617) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3308640..3308646) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3309464 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(3309565..3310641) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" /label="tagO CDS" gene complement(3309565..3310641) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /label="tagO gene" downshifts complement(3309581) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3309627..3309636 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3309650..3309669 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3309658..3310891 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3309658 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3310642..3310724) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3310712..3310731) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3310724) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3310743..3310749) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3310786..3311979) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" /label="tuaH CDS" gene complement(3310786..3311979) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /label="tuaH gene" downshifts complement(3310816) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" /label="downshifts" CDS complement(3312008..3312766) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" /label="tuaG CDS" gene complement(3312008..3312766) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /label="tuaG gene" CDS complement(3312790..3313470) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" /label="tuaF CDS" gene complement(3312790..3313470) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /label="tuaF gene" CDS complement(3313499..3314965) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" /label="tuaE CDS" gene complement(3313499..3314965) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /label="tuaE gene" S_feature complement(3314966..3315049) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3315050..3316435) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" /label="tuaD CDS" gene complement(3315050..3316435) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /label="tuaD gene" CDS complement(3316497..3317666) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" /label="tuaC CDS" gene complement(3316497..3317666) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /label="tuaC gene" CDS complement(3317663..3319114) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" /label="tuaB CDS" gene complement(3317663..3319114) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /label="tuaB gene" CDS complement(3319170..3319319) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" /label="tuaAc CDS" gene complement(3319170..3319319) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo /label="tuaAc gene" CDS complement(3319264..3319803) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" /label="tuaAn CDS" gene complement(3319264..3319803) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo /label="tuaAn gene" misc_feature complement(3319859..3319876) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3319863) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3320030..3321520) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" /label="lytC CDS" gene complement(3320030..3321520) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /label="lytC gene" downshifts complement(3320052) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3321559..3323676) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" /label="lytB CDS" gene complement(3321559..3323676) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /label="lytB gene" CDS complement(3323700..3324008) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" /label="lytA CDS" gene complement(3323700..3324008) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /label="lytA gene" downshifts 3323914 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 3324004..3324008 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3324017..3324031 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3324018..3324036) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3324024 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3324050..3324057) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3324053) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3324074..3324082 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3324096..3324109 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3324114 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="upshifts" CDS 3324192..3325112 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" /label="tagU CDS" gene 3324192..3325112 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /label="tagU gene" downshifts 3325102 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3325152..3326294) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" /label="mnaA CDS" gene complement(3325152..3326294) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /label="mnaA gene" downshifts complement(3325176) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3326333..3326352) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3326347) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3326367..3326370) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3326423..3326427 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3326443..3326462 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3326444..3326539 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3326445 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="upshifts" CDS 3326540..3327418 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" /label="gtaB CDS" gene 3326540..3327418 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /label="gtaB gene" S_feature 3327419..3328510 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3327488..3327843) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3327752..3327970 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" /label="hypothetical protein CDS" gene 3327752..3327970 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /label="gene" CDS complement(3327844..3327927) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" /label="yvzH CDS" gene complement(3327844..3327927) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo /label="yvzH gene" S_feature complement(3327928..3328119) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3328120..3330822) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" /label="ggaB CDS" gene complement(3328120..3330822) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /label="ggaB gene" S_feature complement(3330823..3330945) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3330844..3330850 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3330865..3330883 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3330870..3333702 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3330870 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3330946..3332286) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" /label="ggaA CDS" gene complement(3330946..3332286) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo /label="ggaA gene" CDS complement(3332327..3332533) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" /label="yvzI CDS" gene complement(3332327..3332533) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo /label="yvzI gene" S_feature complement(3332534..3333407) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3333401..3333420) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3333407) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3333409..3333648) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3333433..3333439) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3333630..3333648) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3333648) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="upshifts" promotor_-35 complement(3333662..3333669) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3333671..3333678 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3333690..3333709 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3333704..3333834 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3333704 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3333776..3333876 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3333836 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS 3333840..3334436 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" /label="yvzE CDS" gene 3333840..3334436 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo /label="yvzE gene" downshifts 3334034 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3334475..3336058) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" /label="tagH CDS" gene complement(3334475..3336058) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /label="tagH gene" downshifts 3334518 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" /label="downshifts" CDS complement(3336078..3336905) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " /label="tagG CDS" gene complement(3336078..3336905) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /label="tagG gene" S_feature complement(3336906..3336970) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3336966..3336985) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3336970) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3336972..3337069) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3337001..3337004) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3337070..3339310) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" /label="tagF CDS" gene complement(3337070..3339310) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /label="tagF gene" CDS complement(3339310..3341331) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" /label="tagE CDS" gene complement(3339310..3341331) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /label="tagE gene" promotor_-35 3340073..3340082 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3340095..3340110 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3340106 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3341332..3341491) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3341492..3341881) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" /label="tagD CDS" gene complement(3341492..3341881) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /label="tagD gene" S_feature complement(3341882..3342016) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3342000..3342019) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3342016) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3342030..3342037) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3342171..3342177 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3342188..3342280 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3342188 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3342189..3342208 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3342281..3343051 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" /label="tagA CDS" gene 3342281..3343051 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /label="tagA gene" S_feature complement(3342408..3342756) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3342760..3342771) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3342764) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3342786..3342792) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3343076 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS 3343084..3344229 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" /label="tagB CDS" gene 3343084..3344229 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /label="tagB gene" downshifts 3344217 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" /label="downshifts" promotor_-35 3344271..3344278 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3344293..3344312 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3344303 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="upshifts" CDS 3344349..3345677 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" /label="tagC CDS" gene 3344349..3345677 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /label="tagC gene" downshifts 3345672 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3345733) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3345737..3348379) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" /EC_number="3.2.1.96" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9537764, 10206711, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537764, 10206711, 17298895, 19542270, 22469514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported N-acetylglucosaminidase (major autolysin) (CWBP90)" /protein_id="NP_391459.1" /db_xref="EnsemblGenomes-Gn:BSU35780" /db_xref="EnsemblGenomes-Tr:CAB15595" /db_xref="GOA:P39848" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10455" /db_xref="UniProtKB/Swiss-Prot:P39848" /translation="MKKRLIAPMLLSAASLAFFAMSGSAQAAAYTDYSLYKVEPSNTF STESQASQAVAKLEKDTGWDASYQASGTTTTYQISASGIHSESEAKAILSGLAKQTSI TGTSSPVGSKQPYVTISSGAISGEKQANTILAKLKQETGVAGAVKAYGAAQPYMNVMT SDIADETKVKALIQSLAKQTGIKSSYQPITHTVSVTTIQSGTIVGDSRAAQIKNAFQK ESGLQASLKETVKGQAYYTFTTAAISGEANAKTLLQQLKQSTGITGSYKSINQKTTVE SYNVQSAYFKGLSTVKDAISQIKKNTGVSGSYQQVGKSTSYTVNMKGITKQQLQKIDT FFKKKKWHYTSSSVKKTTTSAAYQITTAKILGEQQANKAAAFFAQKKVKAAKTAAGST AENQYQLISEETSDQAKVTKGLNILKKNQLSASAKSVKKQIADTFKITTESLLDQTKV NQALTFFKSNHISVASQKTGQTAASSYQITTEAIISQEEIDRVLTFFKQNHIAVTTSK TGQTAYTQYKIVTTQLSSKTALNNGLTYLKSKSVTPSYTTKSNTLYKISVNEQFTGND TAAAASTKLKQLYGWTSSIVKIKNGPQIMKTNYNLSLRDMVQKQMTVSPQTDGAAYVS LTYINTATSTVTADVLNIRSTPEVSPTNVIGQFKKGDKVKVIGQINGWAKINLGWRNA SSDEVVQYVDPNNFSRDSKYYFQFLKLSQTAGLSVTEVNQKVLAGKGILTGRAKAFID AANQYSINELYLISHALLETGNGTSALANGLTYNGKTVYNMYGIGAYDSNPNYYGAKY AYEQGWFTPEAAIIGGAKFIGSSYIHNTAYNQDTLYKMRWSATATHQYATDIGWAYKQ VNRMYSLYSLLDGYTLYFDVPEYR*" /label="lytD CDS" gene complement(3345737..3348379) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" /label="lytD gene" promotor_-10 complement(3346982..3347001) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3346984) /Source="Nicolas_upshifts" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3347014..3347023) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3348414..3348432) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3348419) /Source="Nicolas_upshifts" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3348446..3348453) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3348508..3349458) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7581999, 10704478, 19447949, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7581999, 10704478, 19447949, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannose-6-phosphate isomerase (active on aldose substrates with hydroxyl groups oriented in the same direction at the C-2 and C-3 positions as in mannose)" /protein_id="NP_391460.1" /db_xref="EnsemblGenomes-Gn:BSU35790" /db_xref="EnsemblGenomes-Tr:CAB15596" /db_xref="GOA:P39841" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="PDB:1QWR" /db_xref="SubtiList:BG10454" /db_xref="UniProtKB/Swiss-Prot:P39841" /translation="MTQSPIFLTPVFKEKIWGGTALRDRFGYSIPSESTGECWAISAH PKGPSTVANGPYKGKTLIELWEEHREVFGGVEGDRFPLLTKLLDVKEDTSIKVHPDDY YAGENEEGELGKTECWYIIDCKENAEIIYGHTARSKTELVTMINSGDWEGLLRRIKIK PGDFYYVPSGTLHALCKGALVLETQQNSDATYRVYDYDRLDSNGSPRELHFAKAVNAA TVPHVDGYIDESTESRKGITIKTFVQGEYFSVYKWDINGEAEMAQDESFLICSVIEGS GLLKYEDKTCPLKKGDHFILPAQMPDFTIKGTCTLIVSHI*" /label="pmiA CDS" gene complement(3348508..3349458) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" /label="pmiA gene" downshifts complement(3348520) /Source="Nicolas_upshifts" /id="D1850" /incds=0 /nref=29 /ntot=177 /MaxReadThrough="4.74566" /MaxDrop="3.72936" /score="9.64549533" /energy="-7.7" /TU="U2805" /idTUdmin="U2806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3349483..3349501) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3349488) /Source="Nicolas_upshifts" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3349490..3349626) /Source="Nicolas_S_feature" /locus_tag="new_3688579_3688715_c" /HighExp="Lbtran, S0, M40t90, T1.0H, dia0, Mt0, Lbstat, M0t90, Lbexp, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17043900000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1377" promotor_-35 complement(3349516..3349522) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3349600..3349619) /Source="Nicolas_upshift_promotors" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3349628) /Source="Nicolas_upshifts" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3349656..3349662 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3349676..3349687 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3349676 /Source="Nicolas_upshifts" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="upshifts" CDS 3349723..3351174 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391461.2" /db_xref="EnsemblGenomes-Gn:BSU35800" /db_xref="EnsemblGenomes-Tr:CAB15597" /db_xref="GOA:P39569" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10640" /db_xref="UniProtKB/Swiss-Prot:P39569" /translation="MQIDSDLQNNLDTLKKTLGQNDDMMFYTFAFGDSRQKACLLYID GLTENKMLAQYVISPLQKEALAHKECSIEDLSAFFFGFHHSVVSTMKEIEQLVFSGQA ILLADGYRGGLAFDTKSVATRSLDEPSSEVVERGPKIGFIEKLRTNTALLRERTSDPN LVIKEMTLGKRTKKKIAVAYIQDIAPDYVVKEVFKRLKSVNIDNLPESGTLEQLIEDE PFSIFPTILSTERPDRVESSLLEGRVSILVDGTPFALIVPATVDEFIHSPDDYSQRWI PMSLVRLLRYSSILITIYLPGLYISLVSFHTGLLPTRMAISIAGSRLNVPFPPFVEAF IMIFTIELIREAGLRLPKPIGQTIGLIGGVVIGQAAVQAQIVSALMVIVVSVTALASF TVPSYAYNFPLRIIRIGVMISATALGMYGVIMVYLFVIGHLMRLKSFGQDYIIPIMAQ PGQDLKDTVIRIPTMFLKRRPTRNDPEDNIRQR*" /label="gerBA CDS" gene 3349723..3351174 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" /label="gerBA gene" CDS 3351180..3352286 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 22493018; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391462.2" /db_xref="EnsemblGenomes-Gn:BSU35810" /db_xref="EnsemblGenomes-Tr:CAB15598" /db_xref="GOA:P39570" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10641" /db_xref="UniProtKB/Swiss-Prot:P39570" /translation="MRKSEHKLTFMQTLIMISSTLIGAGVLTLPRSAAETGSPSGWLM ILLQGVIFIIIVLLFLPFLQKNSGKTLFKLNSIVAGKFIGFLLNLYICLYFIGIVCFQ ARILGEVVGFFLLKNTPMAVVVFIFLAVAIYHVGGGVYSIAKVYAYIFPITLIIFMML LMFSFRLFQLDFIRPVFEGGYQSFFSLFPKTLLYFSGFEIIFYLVPFMRDPKQVKKAV ALGIATSTLFYSITLLIVIGCMTVAEAKTVTWPTISLIHALEVPGIFIERFDLFLQLT WTAQQFACMLGSFKGAHIGLTEIFHLKNKNNAWLLTAMLAATFFITMYPKDLNDVFYY GTLLGYAFLIVITIPFFVWFLSWIQKKIGRGQLQ*" /label="gerBB CDS" gene 3351180..3352286 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" /label="gerBB gene" CDS 3352283..3353407 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein component of the germination receptor B" /protein_id="NP_391463.1" /db_xref="EnsemblGenomes-Gn:BSU35820" /db_xref="EnsemblGenomes-Tr:CAB15599" /db_xref="GOA:P39571" /db_xref="InterPro:IPR008844" /db_xref="PDB:3N54" /db_xref="SubtiList:BG10642" /db_xref="UniProtKB/Swiss-Prot:P39571" /translation="MKTASKFSVMFFMLLALCGCWDVKDIEQLSFARGLAIDETNDHQ YKLTYQNLLPQSEDSQASGKPEFVNVTSHGKTILEAVSDVSIKDPPVYSDHLKVILLG EKLMRNQNVDQVLNHFIRDDELRRSSYLMAARGNAADVFTKGNPNQQQPMPSEKLIDL TTHSGYNGKIMIPLRIGRASVYSQNGYSYLIQAVKNEKGKAKYDGAGIIKRGSNKLVG FLSADETQTLSWVMGTIQGGVMPTTDKGHPITFEIKKSKTKIKPVIENGKPVFHISVK TKGILTEDQNPNENSFSKSYLHRLENIFEKKLERDVKQVMDKLQHEYKTDPVFLSDHI RIQHPDYWNKVKGHWDEIFSETDFKYDISFKIINFGTVGK*" /label="gerBC CDS" gene 3352283..3353407 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" /label="gerBC gene" S_feature complement(3352510..3353404) /Source="Nicolas_S_feature" /locus_tag="new_3691599_3692493_c" /HighExp="Etha, Sw, Salt, Heat, S8, B36, Gly, S7, LPhT, S6" /AntisenseName="gerBC" /AntisenseCor="0.12062795031199899" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1378" downshifts 3353397 /Source="Nicolas_upshifts" /id="D1851" /incds=0 /nref=18 /ntot=72 /MaxReadThrough="0.37711" /MaxDrop="4.85405" /score="35.6875936" /energy="-14.9" /TU="NA" /idTUdmin="U2807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3353444..3354817) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate/proton transporter" /protein_id="NP_391464.2" /db_xref="EnsemblGenomes-Gn:BSU35830" /db_xref="EnsemblGenomes-Tr:CAB15600" /db_xref="GOA:C0SPB2" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12538" /db_xref="UniProtKB/Swiss-Prot:C0SPB2" /translation="MKKQSNIWLYFFGALGGALYGYDTGVISGAILFMKKELGLNAFT EGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLF RIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEA WRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGTKDIDQEIHDI KEAEKQDEGGLKELFDPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSA SILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFFDNTPA ASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLT YPILMEAIGISYLFLIYAAIGIMAFLFVRFKVTETKGRSLEEIEQDLRDKNGQGGAAG KQQTVGT*" /label="ywtG CDS" gene complement(3353444..3354817) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" /label="ywtG gene" downshifts complement(3353449) /Source="Nicolas_upshifts" /id="D1852" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="6.08746" /MaxDrop="3.99424" /score="22.7548183" /energy="-16.7" /TU="U2808" /idTUdmin="U2808" /TUdmin="-900" /isTUend="FALSE" /label="downshifts" S_feature complement(3354818..3354881) /Source="Nicolas_S_feature" /locus_tag="new_3693907_3693970_c" /HighExp="Etha, Salt, Gly, Heat, Sw, LPhT, HiTm, Diami, B60, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1379" promotor_-10 complement(3354869..3354887) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3354882) /Source="Nicolas_upshifts" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3354902..3354908) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3354968..3354977 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3354989..3355004 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3354991..3355111 /Source="Nicolas_S_feature" /locus_tag="new_3694080_3694200" /HighExp="T-0.40H, LBGstat, T-1.10H, T0.30H, Heat, T-1.40H, T1.30H, T1.0H, T0.0H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1380" upshifts 3354991 /Source="Nicolas_upshifts" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3355086..3355093 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3355107..3355126 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3355113 /Source="Nicolas_upshifts" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" CDS 3355150..3356118 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" /function="12: Regulatory functions" /experiment="publication(s) with functional evidences, PMID:19099556, 22432711, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 22432711, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of capsule synthesis" /protein_id="NP_391465.2" /db_xref="EnsemblGenomes-Gn:BSU35840" /db_xref="EnsemblGenomes-Tr:CAB15601" /db_xref="GOA:Q7WY78" /db_xref="InterPro:IPR004474" /db_xref="PDB:3MEJ" /db_xref="PDB:4DE9" /db_xref="SubtiList:BG12537" /db_xref="UniProtKB/Swiss-Prot:Q7WY78" /translation="MEERSQRRKKKRKLKKWVKVVAGLMAFLVIAAGSVGAYAFVKLN NASKEAHVSLARGEQSVKRIKEFDPGKDSFSVLLLGIDAREKNGETVDQARSDANVLV TFNRKEKTAKMLSIPRDAYVNIPGHGYDKFTHAHAYGGVDLTVKTVEEMLDIPVDYVV ESNFTAFEDVVNELNGVKVTVKSDKVIQQIKKDTKGKVVLQKGTHTLDGEEALAYVRT RKADSDLLRGQRQMEVLSAIIDKSKSLSSIPAYDDIVDTMGQNLKMNLSLKDAIGLFP FITSLKSVESIQLTGYDYEPAGVYYFKLNQQKLQEVKKELQNDLGV*" /label="tagT CDS" gene 3355150..3356118 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" /label="tagT gene" downshifts 3356103 /Source="Nicolas_upshifts" /id="D1853" /incds=0 /nref=27 /ntot=139 /MaxReadThrough="6.07699" /MaxDrop="4.78541" /score="17.3040761" /energy="-17.8" /TU="U2809,U2810" /idTUdmin="U2809" /TUdmin="-1012" /isTUend="FALSE" /label="downshifts" promotor_-35 3356162..3356169 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3356184..3356203 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3356191..3356273 /Source="Nicolas_S_feature" /locus_tag="new_3695280_3695362" /HighExp="Etha, dia5, Lbtran, dia15, LBGexp, LBGtran, G150, Mt0, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.982, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1381" upshifts 3356191 /Source="Nicolas_upshifts" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" CDS 3356274..3357134 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous activity)" /protein_id="NP_391466.1" /db_xref="EnsemblGenomes-Gn:BSU35850" /db_xref="EnsemblGenomes-Tr:CAB15602" /db_xref="GOA:P96741" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12536" /db_xref="UniProtKB/Swiss-Prot:P96741" /translation="MKCIAIDLDGTLLNKESVISAENREAIKRAVDAGILVTICTGRA TFDVKALLDDLDIPIIAANGGTIHDTGYRLISRTLMDQEAGKAIADYLLSKNIYFEVY TDDHLLSPFDGEAKLHAELDILKSANPNEQTDDLWQGAMTQFKQFGIKPIPHIESVFD GGENIYKLLCFSFDMDKLKQAKEELKHHKKLAQTSSGKHIIEILPASSGKGRALTKLA DIYGIETQDIYAIGDSPNDLSMFEVAGHRIAMENAIDELKEKSTFVTKSNDENGVAYF IDQLLSGQYA*" /label="ribZB CDS" gene 3356274..3357134 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" /label="ribZB gene" downshifts 3357115 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3357168..3358409) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" /label="pgdS CDS" gene complement(3357168..3358409) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /label="pgdS gene" downshifts complement(3357187) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3358431..3358449) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3358453) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3358462..3358469) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3358550..3358717) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" /label="edmS CDS" gene complement(3358550..3358717) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /label="edmS gene" downshifts complement(3358577) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" CDS complement(3358732..3359874) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" /label="capA CDS" gene complement(3358732..3359874) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /label="capA gene" CDS complement(3359893..3360342) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" /label="capC CDS" gene complement(3359893..3360342) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /label="capC gene" promotor_-35 3360036..3360042 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3360050 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="upshifts" promotor_-10 3360056..3360074 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3360063..3362272 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3360357..3361538) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" /label="capB CDS" gene complement(3360357..3361538) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /label="capB gene" promotor_-35 3362252..3362259 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3362274 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3362275..3362294 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3362295) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3362300..3362314) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3362322..3362326) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3362322..3363302 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" /label="rbsR CDS" gene 3362322..3363302 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /label="rbsR gene" promotor_-35 3363151..3363158 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3363172..3363191 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3363187 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" CDS 3363304..3364185 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" /label="rbsK CDS" gene 3363304..3364185 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /label="rbsK gene" CDS 3364182..3364577 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" /label="rbsD CDS" gene 3364182..3364577 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /label="rbsD gene" CDS 3364593..3366074 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" /label="rbsA CDS" gene 3364593..3366074 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /label="rbsA gene" CDS 3366076..3367044 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" /label="rbsC CDS" gene 3366076..3367044 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /label="rbsC gene" CDS 3367056..3367973 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" /label="rbsB CDS" gene 3367056..3367973 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /label="rbsB gene" promotor_-35 3367982..3367988 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3368003..3368021 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3368005 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="upshifts" CDS 3368055..3368591 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" /label="ywsB CDS" gene 3368055..3368591 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /label="ywsB gene" downshifts 3368574 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature 3368619..3368729 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3368698..3368704 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3368719..3368730 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3368731 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3368747..3369043 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" /label="ywsA CDS" gene 3368747..3369043 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /label="ywsA gene" S_feature 3369044..3369696 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3369083..3369610) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" /label="ywrO CDS" gene complement(3369083..3369610) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /label="ywrO gene" downshifts complement(3369093) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3369630..3369649) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3369643) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="upshifts" downshifts 3369654 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3369663..3369670) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3369709) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3369710..3370477) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" /label="alsD CDS" gene complement(3369710..3370477) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /label="alsD gene" CDS complement(3370539..3372251) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" /label="alsS CDS" gene complement(3370539..3372251) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /label="alsS gene" promotor_-35 3371150..3371159 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3371173..3371192 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3371173 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3372305..3372324) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3372310) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3372330..3372337 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3372339..3372343) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3372351..3372370 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3372361 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="upshifts" CDS 3372409..3373317 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" /label="alsR CDS" gene 3372409..3373317 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /label="alsR gene" promotor_-35 3373385..3373393 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3373395..3373527 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3373395 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3373407..3373426 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3373528..3374856 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" /label="ywrK CDS" gene 3373528..3374856 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /label="ywrK gene" downshifts 3374847 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3374913..3375590) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" /label="ywrJ CDS" gene complement(3374913..3375590) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /label="ywrJ gene" downshifts complement(3374923) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3375650..3376792) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" /label="cotB CDS" gene complement(3375650..3376792) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /label="cotB gene" promotor_-10 complement(3376829..3376848) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3376837) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3376839..3376919) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3376862..3376870) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3376920..3378008) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" /label="cotH CDS" gene complement(3376920..3378008) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /label="cotH gene" S_feature complement(3378009..3378122) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3378064..3378073 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3378086..3378105 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3378099 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3378122) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3378126..3378140) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3378149..3378153) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3378149..3378736 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" /label="cotG CDS" gene 3378149..3378736 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /label="cotG gene" CDS 3378237..3378716 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " /label="doubtful CDS (putative in frame frameshift)" gene 3378237..3378716 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /label="gene" S_feature complement(3378620..3378817) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3378653 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(3378663) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" /label="downshifts" downshifts 3378722 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts 3378801 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3378816..3378835) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3378822) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3378844..3378851 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3378848..3378857) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3378866..3378885 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3378872 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="upshifts" CDS 3378910..3379527 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" /label="ywrF CDS" gene 3378910..3379527 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /label="ywrF gene" S_feature 3379528..3379628 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3379585 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" /label="downshifts" promotor_-35 3379654..3379663 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3379675..3379690 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3379676 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3379705..3380040 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" /label="ywrE CDS" gene 3379705..3380040 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /label="ywrE gene" promotor_-10 complement(3379996..3380014) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3380005) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3380029..3380034) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3380039 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3380045..3381622) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" /label="hpxW CDS" gene complement(3380045..3381622) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /label="hpxW gene" S_feature 3380084..3381795 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3381773..3381780 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3381791..3381810 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3381797 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3381836..3382312 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" /label="chrS CDS" gene 3381836..3382312 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /label="chrS gene" CDS 3382326..3382919 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" /label="chrB CDS" gene 3382326..3382919 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /label="chrB gene" CDS 3382916..3383452 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" /label="chrA CDS" gene 3382916..3383452 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /label="chrA gene" downshifts 3383433 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(3383479..3383700) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" /label="ywqO CDS" gene complement(3383479..3383700) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /label="ywqO gene" upshifts 3383647 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3383654..3383655 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3383697..3384242) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" /label="ywqN CDS" gene complement(3383697..3384242) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /label="ywqN gene" promotor_-35 3384259..3384266 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3384281..3384300 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3384285 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="upshifts" CDS 3384365..3385246 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" /label="ywqM CDS" gene 3384365..3385246 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /label="ywqM gene" CDS complement(3385331..3386047) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" /label="nfi CDS" gene complement(3385331..3386047) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /label="nfi gene" downshifts complement(3385351) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3386057..3386521) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" /label="rttO CDS" gene complement(3386057..3386521) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /label="rttO gene" CDS complement(3386511..3388319) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" /label="rttN CDS" gene complement(3386511..3388319) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /label="rttN gene" CDS complement(3388338..3388598) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" /label="ywqI CDS" gene complement(3388338..3388598) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /label="ywqI gene" CDS complement(3388608..3389030) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" /label="ywqH CDS" gene complement(3388608..3389030) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /label="ywqH gene" S_feature complement(3389031..3389113) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3389105..3389124) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3389113) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3389137..3389144) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3389247..3389372) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" /label="hypothetical protein CDS" gene complement(3389247..3389372) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /label="gene" S_feature complement(3389290..3389421) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3389333) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3389422..3390207) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" /label="ywqG CDS" gene complement(3389422..3390207) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /label="ywqG gene" S_feature complement(3390208..3390323) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3390316..3390335) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3390323) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3390349..3390356) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3390399..3391721) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" /label="uglF CDS" gene complement(3390399..3391721) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /label="uglF gene" downshifts complement(3390411) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3391755) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3391757..3391882) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3391757..3391775) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3391791..3391796) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3391862..3391881) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3391882) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3391916..3392680) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" /label="ptpZ CDS" gene complement(3391916..3392680) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /label="ptpZ gene" downshifts complement(3392699) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(3392733..3393446) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" /label="ptkA CDS" gene complement(3392733..3393446) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /label="ptkA gene" downshifts complement(3392750) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" /label="downshifts" CDS complement(3393436..3394182) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" /label="tkmA CDS" gene complement(3393436..3394182) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /label="tkmA gene" promotor_-10 complement(3394214..3394233) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3394226) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3394250..3394253) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3394416..3394559) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" /label="ywzD CDS" gene complement(3394416..3394559) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /label="ywzD gene" downshifts complement(3394437) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3394560..3394645) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3394635..3394646) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3394645) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3394647..3394877) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3394684..3394688 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3394704..3394723 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3394713 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="upshifts" CDS 3394763..3396373 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" /label="ywqB CDS" gene 3394763..3396373 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /label="ywqB gene" promotor_-10 complement(3394865..3394883) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3394877) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3394879..3395053) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3394897..3394904) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3395040..3395059) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3395053) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3395073..3395081) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3396360..3399128 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" /label="hepA CDS" gene 3396360..3399128 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /label="hepA gene" downshifts complement(3399177) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3399254..3400111) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" /label="ywpJ CDS" gene complement(3399254..3400111) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /label="ywpJ gene" CDS complement(3400117..3400893) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" /label="glcR CDS" gene complement(3400117..3400893) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /label="glcR gene" promotor_-10 complement(3400919..3400938) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3400941) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3400943..3401015) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3400953..3400960) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3401017..3401116) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3401060) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(3401117..3401458) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" /label="ssbB CDS" gene complement(3401117..3401458) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /label="ssbB gene" promotor_-10 complement(3401480..3401499) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3401499) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3401513..3401520) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3401535..3401918) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" /label="ywpG CDS" gene complement(3401535..3401918) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /label="ywpG gene" promotor_-10 complement(3401940..3401959) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3401947..3401966 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3401951 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3401960) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="upshifts" promotor_-35 complement(3401974..3401981) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3402041..3402060 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3402044 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3402093) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS 3402093..3402503 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" /label="ywpF CDS" gene 3402093..3402503 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /label="ywpF gene" S_feature 3402504..3402587 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3402545 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3402643..3402951) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" /label="ywpE CDS" gene complement(3402643..3402951) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /label="ywpE gene" downshifts complement(3402644) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS 3403295..3404131 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" /label="ywpD CDS" gene 3403295..3404131 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /label="ywpD gene" promotor_-35 3403511..3403518 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3403533..3403552 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3403536 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3404130 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" /label="downshifts" CDS complement(3404178..3404570) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" /label="mscL CDS" gene complement(3404178..3404570) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /label="mscL gene" downshifts complement(3404184) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3404643..3405068) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" /label="fabZ CDS" gene complement(3404643..3405068) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /label="fabZ gene" promotor_-10 complement(3405129..3405148) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3405145) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3405147..3405231) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3405163..3405170) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3405210 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3405213..3405232 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3405223..3405242) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3405231) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="upshifts" S_feature complement(3405233..3406317) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3405256..3405261) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3405260..3406324 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" /label="rapD CDS" gene 3405260..3406324 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /label="rapD gene" S_feature 3406325..3407209 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3406347..3407156) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" /label="flhP CDS" gene complement(3406347..3407156) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /label="flhP gene" downshifts complement(3406362) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3407190..3408002) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" /label="flhO CDS" gene complement(3407190..3408002) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /label="flhO gene" S_feature complement(3408003..3408082) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3408033..3408040 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3408054..3408073 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3408063 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3408076..3408094) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3408082) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="upshifts" promotor_-35 complement(3408108..3408115) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3408165..3409166) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " /label="mbl CDS" gene complement(3408165..3409166) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /label="mbl gene" downshifts complement(3408171) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" misc_feature complement(3409221..3409240) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3409245) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="upshifts" S_feature complement(3409247..3409331) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3409332..3409613) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" /label="spoIIID CDS" gene complement(3409332..3409613) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /label="spoIIID gene" CDS complement(3409628..3409738) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" /label="usd CDS" gene complement(3409628..3409738) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /label="usd gene" promotor_-10 complement(3409769..3409787) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3409791) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3409803..3409808) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3409884..3409890 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3409904..3409923 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3409920 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="upshifts" CDS 3409963..3410376 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" /label="ywoH CDS" gene 3409963..3410376 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /label="ywoH gene" CDS 3410398..3411588 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" /label="ywoG CDS" gene 3410398..3411588 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /label="ywoG gene" CDS complement(3411679..3413085) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" /label="ywoF CDS" gene complement(3411679..3413085) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /label="ywoF gene" downshifts complement(3411976) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3413118..3413137) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3413136) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3413152..3413155) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3413191..3414663) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" /label="pucI CDS" gene complement(3413191..3414663) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /label="pucI gene" CDS complement(3414844..3416202) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" /label="ywoD CDS" gene complement(3414844..3416202) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /label="ywoD gene" downshifts complement(3414858) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3416202..3416771) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" /label="ywoC CDS" gene complement(3416202..3416771) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /label="ywoC gene" promotor_-10 complement(3416790..3416801) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3416808) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3416815..3416821) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3416878..3417045) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" /label="hypothetical protein CDS" gene complement(3416878..3417045) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo /label="gene" CDS complement(3416955..3417419) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" /label="ywoB CDS" gene complement(3416955..3417419) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /label="ywoB gene" promotor_-10 complement(3417449..3417468) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3417454) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3417482..3417489) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3417620..3417623 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3417638..3417657 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3417642 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3417701..3418915 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" /label="amtB CDS" gene 3417701..3418915 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /label="amtB gene" promotor_-10 complement(3418531..3418549) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3418532) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3418563..3418570) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3418781..3418787 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3418801..3418820 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3418803 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3418927..3419277 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" /label="glnK CDS" gene 3418927..3419277 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /label="glnK gene" downshifts 3419270 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3419329..3419337 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3419351..3419359 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3419358 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3419400..3419409 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3419422..3419437 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3419426 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" CDS 3419458..3420039 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" /label="bcrC CDS" gene 3419458..3420039 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /label="bcrC gene" promotor_-10 complement(3419556..3419575) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3419566) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3419589..3419597) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3420020 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(3420080..3420502) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" /label="ywnJ CDS" gene complement(3420080..3420502) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /label="ywnJ gene" downshifts complement(3420099) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3420537..3420552) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3420556) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3420565..3420574) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3420613..3421464) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" /label="spoIIQ CDS" gene complement(3420613..3421464) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /label="spoIIQ gene" downshifts complement(3420622) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts complement(3420864) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" promotor_-35 3421101..3421103 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3421120..3421139 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3421121..3421467 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3421121 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3421459..3421462 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3421469..3421604 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3421469 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3421498) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3421504..3421513) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3421605..3422096 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" /label="ywnH CDS" gene 3421605..3422096 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /label="ywnH gene" promotor_-35 3421834..3421839 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3421855..3421873 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3421866 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3421957..3422865) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3422093..3422611 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" /label="ywnG CDS" gene 3422093..3422611 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /label="ywnG gene" downshifts 3422416 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 3422614 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3422770..3422901 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " /label="hypothetical protein CDS" gene 3422770..3422901 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /label="gene" CDS complement(3422898..3423332) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" /label="ywnF CDS" gene complement(3422898..3423332) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /label="ywnF gene" downshifts complement(3422910) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3423381..3423400) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3423388) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3423390..3423687) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3423415..3423422) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3423461..3423465 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3423482..3423501 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3423494..3423574 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3423495 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3423575..3425023 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" /label="clsA CDS" gene 3423575..3425023 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /label="clsA gene" upshifts complement(3423687) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3423688..3423706) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3423689..3424032) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3423722..3423728) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3424010..3424028) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3424032) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3424044..3424049) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3425012 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3425044..3425817) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" /label="mta CDS" gene complement(3425044..3425817) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /label="mta gene" downshifts complement(3425066) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" promotor_-35 3425892..3425895 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3425911..3425930 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3425915 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="upshifts" CDS 3425962..3426345 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" /label="ywnC CDS" gene 3425962..3426345 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /label="ywnC gene" downshifts 3426332 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3426380..3427021) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" /label="ywnB CDS" gene complement(3426380..3427021) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /label="ywnB gene" downshifts complement(3426430) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3427089..3427490) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" /label="ywnA CDS" gene complement(3427089..3427490) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /label="ywnA gene" promotor_-10 complement(3427539..3427558) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3427549) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3427551..3427624) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3427573..3427578) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3427625..3429334) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" /label="ureC CDS" gene complement(3427625..3429334) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /label="ureC gene" CDS complement(3429331..3429705) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" /label="ureB CDS" gene complement(3429331..3429705) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /label="ureB gene" CDS complement(3429702..3430019) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" /label="ureA CDS" gene complement(3429702..3430019) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /label="ureA gene" S_feature complement(3430020..3430104) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3430104) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3430106..3430119) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3430106..3430199) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3430200..3430364) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" /label="ywzE CDS" gene complement(3430200..3430364) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /label="ywzE gene" promotor_-10 complement(3430287..3430305) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3430299) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="upshifts" promotor_-35 complement(3430317..3430325) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3430365..3430536) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3430537..3430719) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" /label="ywzF CDS" gene complement(3430537..3430719) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo /label="ywzF gene" S_feature complement(3430720..3430866) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3430854..3430873) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3430866) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" S_feature complement(3430868..3430982) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3430888..3430895) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" Polymorphism join(3430969,3430971) /Source="geneious" /ID="SNP_BsDelta6_3770059_3770058" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)8 -> (A)9" /Codon_Change /Coverage=64 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="2.1e-197" /Variant_Raw_Frequency=61 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 3430996 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3430999..3431003 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3431016..3431204) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" /label="csbD CDS" gene complement(3431016..3431204) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /label="csbD gene" downshifts complement(3431027) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" /label="downshifts" downshifts 3431194 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3431230..3431248) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3431241) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3431262..3431268) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3431277..3431777) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" /label="ywmF CDS" gene complement(3431277..3431777) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /label="ywmF gene" promotor_-10 complement(3431813..3431832) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3431820) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3431846..3431852) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3431912..3433045) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" /label="rapB CDS" gene complement(3431912..3433045) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /label="rapB gene" downshifts complement(3431930) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3433072..3433091) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3433079) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3433142..3433160) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3433158) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3433174..3433181) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3433237..3434262) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" /label="moaA CDS" gene complement(3433237..3434262) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /label="moaA gene" downshifts complement(3433250) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3434278..3435066) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" /label="fdhD CDS" gene complement(3434278..3435066) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /label="fdhD gene" promotor_-10 complement(3435092..3435111) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3435098) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3435100..3435311) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3435125..3435132) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3435312..3435473) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" /label="ywmE CDS" gene complement(3435312..3435473) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /label="ywmE gene" promotor_-10 complement(3435486..3435504) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3435506) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="upshifts" promotor_-35 complement(3435518..3435524) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3435567..3436241) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" /label="ywmD CDS" gene complement(3435567..3436241) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /label="ywmD gene" downshifts complement(3435582) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3436294..3436434) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" /label="hypothetical protein CDS" gene complement(3436294..3436434) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /label="gene" CDS complement(3436565..3437248) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" /label="ywmC CDS" gene complement(3436565..3437248) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /label="ywmC gene" promotor_-35 3437625..3437629 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3437634..3438665) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" /label="spoIID CDS" gene complement(3437634..3438665) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /label="spoIID gene" promotor_-10 3437644..3437663 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3437650) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3437662 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3438693..3438711) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3438706) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3438708..3438825) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3438727..3438732) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3438767..3438772 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3438784..3441444 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3438784 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3438788..3438806 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3438861..3440171) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" /label="murAA CDS" gene complement(3438861..3440171) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /label="murAA gene" downshifts complement(3438870) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3440195..3440214) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3440202) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3440205..3440945) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" /label="ywmB CDS" gene complement(3440205..3440945) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /label="ywmB gene" promotor_-35 complement(3440228..3440237) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3440576) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3440578..3440586) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3440600..3440608) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3440700..3440715) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3440708) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3440728..3440737) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3440946..3441073) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3441074..3441304) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" /label="ywzB CDS" gene complement(3441074..3441304) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /label="ywzB gene" S_feature complement(3441305..3441567) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3441440..3441459 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3441446 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="upshifts" CDS 3441474..3441947 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" /label="ywmA CDS" gene 3441474..3441947 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /label="ywmA gene" promotor_-10 complement(3441551..3441570) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3441567) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="upshifts" S_feature complement(3441569..3441952) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3441585..3441588) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3441981..3442379) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" /label="atpC CDS" gene complement(3441981..3442379) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /label="atpC gene" downshifts complement(3441997) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3442371..3442389) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3442380) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3442403..3442409) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3442403..3443824) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" /label="atpD CDS" gene complement(3442403..3443824) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /label="atpD gene" CDS complement(3443850..3444713) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" /label="atpG CDS" gene complement(3443850..3444713) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /label="atpG gene" S_feature complement(3444714..3444789) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3444790..3446298) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" /label="atpA CDS" gene complement(3444790..3446298) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /label="atpA gene" CDS complement(3446315..3446860) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" /label="atpH CDS" gene complement(3446315..3446860) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /label="atpH gene" CDS complement(3446857..3447369) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" /label="atpF CDS" gene complement(3446857..3447369) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /label="atpF gene" S_feature complement(3447370..3447531) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3447532..3447744) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" /label="atpE CDS" gene complement(3447532..3447744) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /label="atpE gene" CDS complement(3447790..3448524) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" /label="atpB CDS" gene complement(3447790..3448524) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /label="atpB gene" promotor_no_box 3448338..3448438 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3448398 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3448532..3448915) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" /label="atpI CDS" gene complement(3448532..3448915) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /label="atpI gene" misc_feature complement(3448604..3448622) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3448606) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3448916..3449186) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3449148..3449157 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3449157 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3449162..3449181) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3449171..3449190 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3449186) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3449188..3449309) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3449194..3449201) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3449338..3449967) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" /label="upp CDS" gene complement(3449338..3449967) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /label="upp gene" downshifts complement(3449354) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3450011..3450030) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3450034) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" promotor_-35 complement(3450045..3450052) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3450102..3451349) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" /label="glyA CDS" gene complement(3450102..3451349) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /label="glyA gene" downshifts complement(3450125) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3451391..3451410) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3451408) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3451410..3451494) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3451425..3451430) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3451539) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" /label="downshifts" CDS complement(3451556..3452098) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" /label="ywlG CDS" gene complement(3451556..3452098) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /label="ywlG gene" CDS complement(3452111..3452560) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" /label="rpiB CDS" gene complement(3452111..3452560) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /label="rpiB gene" S_feature complement(3452561..3452660) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3452652..3452671) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3452660) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="upshifts" promotor_-35 complement(3452685..3452692) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3452717..3453169) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" /label="prpB CDS" gene complement(3452717..3453169) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /label="prpB gene" promotor_-10 complement(3453186..3453205) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3453204) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="upshifts" promotor_-35 complement(3453220..3453223) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3453245..3453802) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" /label="mntP CDS" gene complement(3453245..3453802) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /label="mntP gene" promotor_-10 complement(3453829..3453847) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3453842) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="upshifts" promotor_-35 complement(3453863..3453868) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3453881..3454921) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" /label="tsaC CDS" gene complement(3453881..3454921) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /label="tsaC gene" downshifts complement(3453886) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3454922..3454986) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3454976..3454995) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3454986) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3454988..3455077) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3455011..3455015) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3455078..3455521) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" /label="ywlB CDS" gene complement(3455078..3455521) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /label="ywlB gene" CDS complement(3455588..3456262) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" /label="spoIIR CDS" gene complement(3455588..3456262) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /label="spoIIR gene" promotor_-10 complement(3456024..3456042) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3456031) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3456057..3456063) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3456294..3456311) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3456295) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3456327..3456332) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3456368 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3456372..3456391 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3456403..3456765 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" /label="ywlA CDS" gene 3456403..3456765 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /label="ywlA gene" downshifts complement(3456778) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3456782..3457069) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" /label="ywkF CDS" gene complement(3456782..3457069) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /label="ywkF gene" S_feature complement(3457070..3457128) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3457126..3457145) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3457129..3457995) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" /label="prmC CDS" gene complement(3457129..3457995) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /label="prmC gene" upshifts complement(3457142) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3457158..3457167) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3457997..3459067) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" /label="prfA CDS" gene complement(3457997..3459067) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /label="prfA gene" downshifts complement(3458000) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" downshifts 3459068 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3459095..3459114) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3459119) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3459121..3459232) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3459128..3459134) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3459164..3459183 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3459178 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3459193..3459579 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" /label="ywkD CDS" gene 3459193..3459579 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /label="ywkD gene" promotor_-10 complement(3459214..3459232) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3459232) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="upshifts" promotor_-35 complement(3459246..3459253) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3459647..3459655 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3459666..3459684 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3459667 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3459701..3460255 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" /label="racA CDS" gene 3459701..3460255 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /label="racA gene" misc_feature 3460185..3460189 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3460190 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3460234 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3460289..3461248) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" /label="ywkB CDS" gene complement(3460289..3461248) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /label="ywkB gene" downshifts complement(3460311) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3461286..3461304) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3461300) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3461319..3461325) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3461330..3463078) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" /label="maeA CDS" gene complement(3461330..3463078) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /label="maeA gene" promotor_-10 complement(3461804..3461822) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3461812) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3461837..3461843) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3463079..3463169) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3463153..3463172) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3463169) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3463186..3463193) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3463312) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(3463317..3463904) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" /label="tdk CDS" gene complement(3463317..3463904) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /label="tdk gene" CDS complement(3463993..3464193) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" /label="rpmEA CDS" gene complement(3463993..3464193) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /label="rpmEA gene" downshifts complement(3464006) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3464194..3464271) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3464267..3464286) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3464271) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3464300..3464307) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3464312..3465595) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" /label="rho CDS" gene complement(3464312..3465595) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /label="rho gene" S_feature complement(3465596..3465898) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3465626..3465787) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" /label="hypothetical protein CDS" gene complement(3465626..3465787) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /label="gene" promotor_-10 complement(3465878..3465897) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3465898) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3465913..3465917) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3466002..3466967) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" /label="glpX CDS" gene complement(3466002..3466967) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /label="glpX gene" downshifts complement(3466008) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 3466584..3466593 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3466606..3466625 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3466614 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3466998..3468287) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" /label="murAB CDS" gene complement(3466998..3468287) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /label="murAB gene" S_feature complement(3468288..3468647) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3468666..3469304) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" /label="tal CDS" gene complement(3468666..3469304) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /label="tal gene" downshifts complement(3468692) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" S_feature complement(3469305..3469423) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3469424..3470281) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" /label="fbaA CDS" gene complement(3469424..3470281) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /label="fbaA gene" S_feature complement(3470282..3470408) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3470390..3470409) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3470408) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="upshifts" promotor_-35 complement(3470423..3470430) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3470462..3470836) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" /label="spo0F CDS" gene complement(3470462..3470836) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /label="spo0F gene" promotor_-10 complement(3470876..3470894) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3470890) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="upshifts" S_feature complement(3470892..3471531) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3470893..3470896 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3470905..3470913) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3470912..3470931 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3470925 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3470939..3470944 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3470960..3470979 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3470970 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" CDS 3471002..3471523 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" /label="ywjG CDS" gene 3471002..3471523 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /label="ywjG gene" promotor_-35 3471466..3471469 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3471484..3471503 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3471498 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3471521..3471540) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3471531) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="upshifts" downshifts 3471542 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3471555..3471562) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3471605..3473212) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" /label="pyrG CDS" gene complement(3471605..3473212) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /label="pyrG gene" downshifts complement(3471618) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3473213..3473400) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3473388..3473407) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3473400) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3473422..3473429) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3473454..3473975) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" /label="rpoE CDS" gene complement(3473454..3473975) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /label="rpoE gene" downshifts complement(3473510) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" S_feature complement(3473976..3474078) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3474059..3474078) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3474078) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3474080..3474157) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3474094..3474097) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3474158..3475297) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" /label="acdA CDS" gene complement(3474158..3475297) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /label="acdA gene" CDS complement(3475294..3477411) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" /label="fadF CDS" gene complement(3475294..3477411) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /label="fadF gene" S_feature complement(3477412..3477470) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3477471..3477490) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3477484) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3477504..3477511) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3477510..3477516 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3477530..3477541 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3477535 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="upshifts" CDS 3477566..3478762 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" /label="clsB CDS" gene 3477566..3478762 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /label="clsB gene" S_feature complement(3477758..3478636) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3478626..3478644) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3478637) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3478660..3478665) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3478775..3479737 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" /label="uvsE CDS" gene 3478775..3479737 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /label="uvsE gene" promotor_-35 3479751..3479757 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3479772..3479790 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3479772 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="upshifts" CDS 3479818..3480090 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" /label="ywjC CDS" gene 3479818..3480090 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /label="ywjC gene" downshifts complement(3479824) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 3480080 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" /label="downshifts" S_feature 3480125..3480531 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3480132..3480656) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" /label="ywjB CDS" gene complement(3480132..3480656) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /label="ywjB gene" downshifts complement(3480154) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3480666..3482393) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" /label="ywjA CDS" gene complement(3480666..3482393) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /label="ywjA gene" promotor_-10 complement(3482427..3482446) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3482441) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3482460..3482466) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3482482..3483984) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" /label="clsC CDS" gene complement(3482482..3483984) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /label="clsC gene" promotor_-10 complement(3484008..3484026) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3484026) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3484041..3484047) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3484071..3484443) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3484114) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3484470..3485141) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" /label="narI CDS" gene complement(3484470..3485141) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /label="narI gene" downshifts complement(3484488) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(3485138..3485692) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" /label="narJ CDS" gene complement(3485138..3485692) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /label="narJ gene" CDS complement(3485718..3487181) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" /label="narH CDS" gene complement(3485718..3487181) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /label="narH gene" CDS complement(3487171..3490857) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" /label="narG CDS" gene complement(3487171..3490857) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /label="narG gene" misc_feature complement(3490888..3490907) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3490912) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3490914..3491043) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3491053..3491529) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" /label="arfM CDS" gene complement(3491053..3491529) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /label="arfM gene" downshifts complement(3491088) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3491552..3491571) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3491564) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="upshifts" promotor_-35 complement(3491586..3491589) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3491636 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3491639..3491658 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3491673..3492392 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" /label="ywiC CDS" gene 3491673..3492392 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /label="ywiC gene" downshifts 3492376 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3492424..3493140) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" /label="fnr CDS" gene complement(3492424..3493140) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /label="fnr gene" downshifts complement(3492426) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" /label="downshifts" downshifts complement(3492496) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" misc_feature complement(3493166..3493185) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3493178) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3493239..3494426) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" /label="narK CDS" gene complement(3493239..3494426) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /label="narK gene" misc_feature complement(3494456..3494475) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3494474) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3494562..3496232) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" /label="argS CDS" gene complement(3494562..3496232) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /label="argS gene" downshifts complement(3494564) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3496229..3496657) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" /label="ywiB CDS" gene complement(3496229..3496657) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /label="ywiB gene" misc_feature 3496725..3496739 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3496725..3496744) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3496732 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3496741) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3496761..3496764) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3496796..3496815) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3496808) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="upshifts" promotor_-35 3496888..3496895 /Source="Nicolas_upshift_promotors" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3496903 /Source="Nicolas_upshifts" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3496908..3496927 /Source="Nicolas_upshift_promotors" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 3496952 /Source="Nicolas_upshifts" /id="D1933" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="8.77621" /MaxDrop="1.77243" /score="6.03938699" /energy="-13.2" /TU="U2943" /idTUdmin="U2937" /TUdmin=4576 /isTUend="FALSE" /label="downshifts" CDS 3496970..3497101 /gene="sboA" /locus_tag="BSU_37350" /old_locus_tag="BSU37350" /function="16.8: Protect" /function="16.4: Excrete" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12696888, 15743949, 16095584, 17213266, 27914001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12696888, 15743949, 16095584, 17213266, 27914001; Product type f: factor" /codon_start=1 /transl_table=11 /product="subtilosin A" /protein_id="NP_391616.1" /db_xref="EnsemblGenomes-Gn:BSU37350" /db_xref="EnsemblGenomes-Tr:CAB15763" /db_xref="GOA:O07623" /db_xref="InterPro:IPR021539" /db_xref="PDB:1PXQ" /db_xref="SubtiList:BG12671" /db_xref="UniProtKB/Swiss-Prot:O07623" /translation="MKKAVIVENKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG* " /label="sboA CDS" gene 3496970..3497101 /gene="sboA" /locus_tag="BSU_37350" /old_locus_tag="BSU37350" /label="sboA gene" CDS 3497058..3497210 /gene="sboX" /locus_tag="BSU_37360" /old_locus_tag="BSU37360" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin-like product" /protein_id="YP_054594.1" /db_xref="EnsemblGenomes-Gn:BSU37360" /db_xref="EnsemblGenomes-Tr:CAE01468" /db_xref="SubtiList:BG14182" /db_xref="UniProtKB/Swiss-Prot:Q7WY57" /translation="MKLPVQQVYSVYGGKDLPKGHSHSTMPFLSKLQFLTKIYLLDIH TQPFFI*" /label="sboX CDS" gene 3497058..3497210 /gene="sboX" /locus_tag="BSU_37360" /old_locus_tag="BSU37360" /label="sboX gene" downshifts 3497090 /Source="Nicolas_upshifts" /id="D1934" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="8.85351" /MaxDrop="5.1396" /score="6.03938699" /energy="-13.2" /TU="U2943" /idTUdmin="U2937" /TUdmin=4714 /isTUend="FALSE" /label="downshifts" promotor_-35 3497205..3497211 /Source="Nicolas_upshift_promotors" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3497226..3497245 /Source="Nicolas_upshift_promotors" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3497229 /Source="Nicolas_upshifts" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="upshifts" CDS 3497235..3498581 /gene="albA" /locus_tag="BSU_37370" /old_locus_tag="BSU37370" /EC_number="1.21.98.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066831, 15743949, 22366720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066831, 15743949, 22366720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subtilosin A thioether formation enzyme" /protein_id="NP_391617.1" /db_xref="EnsemblGenomes-Gn:BSU37370" /db_xref="EnsemblGenomes-Tr:CAB15764" /db_xref="GOA:P71011" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR008792" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017200" /db_xref="InterPro:IPR023885" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG12471" /db_xref="UniProtKB/Swiss-Prot:P71011" /translation="MFIEQMFPFINESVRVHQLPEGGVLEIDYLRDNVSISDFEYLDL NKTAYELCMRMDGQKTAEQILAEQCAVYDESPEDHKDWYYDMLNMLQNKQVIQLGNRA SRHTITTSGSNEFPMPLHATFELTHRCNLKCAHCYLESSPEALGTVSIEQFKKTADML FDNGVLTCEITGGEIFVHPNANEILDYVCKKFKKVAVLTNGTLMRKESLELLKTYKQK IIVGISLDSVNSEVHDSFRGRKGSFAQTCKTIKLLSDHGIFVRVAMSVFEKNMWEIHD MAQKVRDLGAKAFSYNWVDDFGRGRDIVHPTKDAEQHRKFMEYEQHVIDEFKDLIPII PYERKRAANCGAGWKSIVISPFGEVRPCALFPKEFSLGNIFHDSYESIFNSPLVHKLW QAQAPRFSEHCMKDKCPFSGYCGGCYLKGLNSNKYHRKNICSWAKNEQLEDVVQLI*" /label="albA CDS" gene 3497235..3498581 /gene="albA" /locus_tag="BSU_37370" /old_locus_tag="BSU37370" /label="albA gene" CDS 3498594..3498755 /gene="albB" /locus_tag="BSU_37380" /old_locus_tag="BSU37380" /function="16.4: Excrete" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809709, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809709, 15743949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane component involved in subtilosin production" /protein_id="NP_391618.1" /db_xref="EnsemblGenomes-Gn:BSU37380" /db_xref="EnsemblGenomes-Tr:CAB15765" /db_xref="GOA:P71010" /db_xref="SubtiList:BG12470" /db_xref="UniProtKB/Swiss-Prot:P71010" /translation="MSPAQRRILLYILSFIFVIGAVVYFVKSDYLFTLIFIAIAILFG MRARKADSR*" /label="albB CDS" gene 3498594..3498755 /gene="albB" /locus_tag="BSU_37380" /old_locus_tag="BSU37380" /label="albB gene" CDS 3498752..3499471 /gene="albC" /locus_tag="BSU_37390" /old_locus_tag="BSU37390" /function="16.5: Explore" /function="16.6: Maintain" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15743949; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter involved in subtilosin production" /protein_id="NP_391619.1" /db_xref="EnsemblGenomes-Gn:BSU37390" /db_xref="EnsemblGenomes-Tr:CAB15766" /db_xref="GOA:P71009" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12469" /db_xref="UniProtKB/Swiss-Prot:P71009" /translation="MSILDIHDVSVWYERDNVILEQVDLHLEKGAVYGLLGVNGAGKT TLINTLTGVNRNFSGRFTLCGIEAEAGMPQKTSDQLKTHRYFAADYPLLFTEITAKDY VSFVHSLYQKDFSEQQFASLAEAFHFSKYINRRISELSLGNRQKVVLMTGLLLRAPLF ILDEPLVGLDVESIEVFYQKMREYCEAGGTILFSSHLLDVVQRFCDYAAILHNKQIQK VIPIGEETDLRREFFEVIGHE*" /label="albC CDS" gene 3498752..3499471 /gene="albC" /locus_tag="BSU_37390" /old_locus_tag="BSU37390" /label="albC gene" CDS 3499464..3500774 /gene="albD" /locus_tag="BSU_37400" /old_locus_tag="BSU37400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10809709, 15066831, 15743949, 15849754, 16850406, 18034824; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral membrane protein involved in subtilosinproduction and immunity" /protein_id="NP_391620.1" /db_xref="EnsemblGenomes-Gn:BSU37400" /db_xref="EnsemblGenomes-Tr:CAB15767" /db_xref="GOA:P71008" /db_xref="SubtiList:BG12468" /db_xref="UniProtKB/Swiss-Prot:P71008" /translation="MNNIIPIMSLLFKQLYSRQGKKDAIRIAAGLVILAVFEIGLIRQ AGIDESVLRKTYIILALLLMNTYMVFLSVTSQWKESYMKLSCLLPISSRSFWLAQSVV LFVDTCLRRTLFFFILPLFLFGNGTLSGAQTLFWLGRFSFFTVYSIIFGVVLSNHFVK KKNLMFLLHAAIFACVCISAALMPAATIPLCAVHILWAVVIDFPVFLQAPPQQGKMHS FMRRSEFSFYKREWNRFISSKAMLLNYAVMAVFSGFFSFQMMNTGIFNQQVIYIVISA LLLICSPIALLYSIEKNDRMLLITLPIKRKTMFWAKYRFYSGLLAGGFLLVVMIVGFI SGRSISVLTFLQCIELLLAGAYIRLTADEKRPSFSWQTEQQLWSGFSKYRSYLFCLPL FLAILAGTAVSLAVIPIAGLVIVYYLQKQDGGFFDTSKRERLGS*" /label="albD CDS" gene 3499464..3500774 /gene="albD" /locus_tag="BSU_37400" /old_locus_tag="BSU37400" /label="albD gene" CDS 3500764..3501924 /gene="albE" /locus_tag="BSU_37410" /old_locus_tag="BSU37410" /function="16.8: Protect" /function="16.5: Explore" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10809709, 15066831, 15743949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase involved in subtilosin A production" /protein_id="NP_391621.1" /db_xref="EnsemblGenomes-Gn:BSU37410" /db_xref="EnsemblGenomes-Tr:CAB15768" /db_xref="GOA:P71007" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG12467" /db_xref="UniProtKB/Swiss-Prot:P71007" /translation="MEVNLLKTHQFSTISIAASFLKPIESAAEPEEETIYFYGAAAYL KEQIIDAFGYAAGSRFMYSANLFFDQQLKTCGTRLIHPLYNGNLHVDALMKTFADLSF PSSLSFEAFEKARNELLLKIEKKFTDPFSYSAARLAEEVFGNPMYGTGMFGRRDRIKA IHPKRFLDATDFIVDLVSQQKQLNILGQVQACDVRGHAPQTSAVTSGRIPVNRHVFET ETRSAAGPSVLTLGFDCGEMKDASDYIKIQLIDGLLGKYGHSALFKHFREKDLAVYHV ITRYDVMNNLLLVSICTDQLHEKDIPPRVLEAVSAFHTDERELEQAKQFLRNELLLQF DSPEGLLAYMGVLRRFSCTKEALLDGISAVTCRDVLQFIATINYIGAHVVRG*" /label="albE CDS" gene 3500764..3501924 /gene="albE" /locus_tag="BSU_37410" /old_locus_tag="BSU37410" /label="albE gene" CDS 3501929..3503209 /gene="albF" /locus_tag="BSU_37420" /old_locus_tag="BSU37420" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.4: Excrete" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15743949, 25817994; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase involved in subtilosin production" /protein_id="NP_391622.1" /db_xref="EnsemblGenomes-Gn:BSU37420" /db_xref="EnsemblGenomes-Tr:CAB15769" /db_xref="GOA:P71006" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG12466" /db_xref="UniProtKB/Swiss-Prot:P71006" /translation="MEKKAFFQQLDERTDIRYTDSGLKIFRLKFPRAHLRLCNVKIDF GSRDVCIRAESGDTLLPYGTAHFLEHLLFWHNGRNLYSDFFAHGALLNAFTTYTDTNF MFTSLPDRLRQTIPILLDALWNHSFDKKIVAQEKAVITSEIQTAHLNHQLSYHYQLIS MLSPSSPAAVFPAGRIEDIEALDISDLQKAYKAAYQAHRMTLFLIGGSENTETLLPPH LQLEKRPDYHAERKIIPACPPVLSQKMMLGDEERMEDTWTGLQIGALPGQNDLLSIKL YWDIAARILFQLDSPFFQEIQQTYRLEIDRLSAETYIYEDGGFLILHSQGTHSSAYID VASYYVTQKKEQVAAWLQYGKDSLTDAIIYDSDYVRKCFEWAAECDRCDCSFLDMYHI IQDMDAQVFLSLIDAMASSNKAIIHVSQKEAIRQ*" /label="albF CDS" gene 3501929..3503209 /gene="albF" /locus_tag="BSU_37420" /old_locus_tag="BSU37420" /label="albF gene" CDS 3503206..3503907 /gene="albG" /locus_tag="BSU_37430" /old_locus_tag="BSU37430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein involved in subtilosin production and immunity" /protein_id="NP_391623.1" /db_xref="EnsemblGenomes-Gn:BSU37430" /db_xref="EnsemblGenomes-Tr:CAB15770" /db_xref="GOA:P71005" /db_xref="SubtiList:BG12465" /db_xref="UniProtKB/Swiss-Prot:P71005" /translation="MKQSTVFTLLLLLIGMAAYSFGWVQAVAEAAAQYVQMINNDAVR LGLLACTAALLMLPAFLYLHYVTQSVKNMTAAFQKLTQSHQSCCDFQQHNLCSRYAED VKSLRDSYKNVRQTYVMAAVLCQVIIFGCMFEIVKAVPFRLHTPPAFSMGLAMLLILY LLFCMRTYLRQLFRHGSLFRKVFAGALAAAGIWWMLSFSISELLFLIILAAIQQIGSF IYKRFSYHSTASLDL*" /label="albG CDS" gene 3503206..3503907 /gene="albG" /locus_tag="BSU_37430" /old_locus_tag="BSU37430" /label="albG gene" downshifts complement(3503474) /Source="Nicolas_upshifts" /id="D1935" /incds=1 /nref=2 /ntot=5 /MaxReadThrough="0.362109999999999" /MaxDrop="3.55474" /score="6.50386958" /energy="-12" /TU="NA" /idTUdmin="U2945" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3503563..3503912) /Source="Nicolas_S_feature" /locus_tag="new_3842651_3843000_c" /HighExp="BT, B36, B60, Pyr, G/S, Mal, S3, G135, M/G, Sw" /AntisenseName="albG" /AntisenseCor="2.0087959212361201E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1449" downshifts complement(3503606) /Source="Nicolas_upshifts" /id="D1936" /incds=1 /nref=6 /ntot=18 /MaxReadThrough="3.01883" /MaxDrop="4.2137" /score="6.50386958" /energy="-12" /TU="U2945" /idTUdmin="U2945" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 3503908..3506390 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3503913..3505289) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" /label="ywhL CDS" gene complement(3503913..3505289) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /label="ywhL gene" CDS complement(3505328..3506683) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" /label="ywhK CDS" gene complement(3505328..3506683) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /label="ywhK gene" promotor_-10 complement(3506719..3506738) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3506737) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3506751..3506760) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3506863..3506882 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3506864 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3506909) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" /label="downshifts" CDS 3506913..3508058 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" /label="rapF CDS" gene 3506913..3508058 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /label="rapF gene" promotor_-35 3507917..3507921 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3507938..3507957 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3507945 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3508028) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 3508042..3508161 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" /label="phrF CDS" gene 3508042..3508161 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /label="phrF gene" downshifts 3508146 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" S_feature 3508191..3508259 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3508260..3508733 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" /label="ywhH CDS" gene 3508260..3508733 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /label="ywhH gene" downshifts 3508722 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3508765..3509637) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" /label="speB CDS" gene complement(3508765..3509637) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /label="speB gene" downshifts complement(3508776) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3508842) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(3509698..3510528) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" /label="speE CDS" gene complement(3509698..3510528) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /label="speE gene" S_feature complement(3510529..3510624) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3510612..3510631) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3510623) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3510644..3510651) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3510669..3510674 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3510690..3510708 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3510692 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="upshifts" CDS 3510730..3512805 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" /label="pbpG CDS" gene 3510730..3512805 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /label="pbpG gene" downshifts complement(3512858) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(3512982..3513097) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3513025) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" /label="downshifts" CDS complement(3513098..3513616) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" /label="ywhD CDS" gene complement(3513098..3513616) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /label="ywhD gene" CDS complement(3513630..3514289) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" /label="ywhC CDS" gene complement(3513630..3514289) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /label="ywhC gene" promotor_-35 3514312..3514315 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3514325..3514344) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3514330..3514349 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3514333 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3514343) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3514345..3514628) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3514359..3514366) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3514398..3514586 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" /label="hmtB CDS" gene 3514398..3514586 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /label="hmtB gene" downshifts 3514575 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3514629..3515048) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" /label="ywhA CDS" gene complement(3514629..3515048) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /label="ywhA gene" promotor_-10 complement(3515098..3515117) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3515109) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3515132..3515139) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3515168..3517084) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" /label="thrZ CDS" gene complement(3515168..3517084) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /label="thrZ gene" promotor_-10 complement(3516362..3516380) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3516367) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3516397..3516401) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3517115) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3517138..3517359) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTB RNA" gene complement(3517138..3517359) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /label="tboTB gene" misc_RNA complement(3517391..3517612) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTA RNA" gene complement(3517391..3517612) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /label="tboTA gene" S_feature complement(3517644..3517906) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3517655 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" /label="downshifts" downshifts complement(3517687) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3517694..3517849) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" /label="hypothetical protein CDS" gene complement(3517694..3517849) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /label="gene" promotor_-35 3517856..3517859 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3517868..3517881 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3517875 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3517883..3517902) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3517906) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3517916..3517922) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3517929..3519329) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" /label="mmr CDS" gene complement(3517929..3519329) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /label="mmr gene" CDS complement(3519329..3519799) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" /label="ywgB CDS" gene complement(3519329..3519799) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /label="ywgB gene" downshifts complement(3519755) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3519911..3520411) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" /label="ywgA CDS" gene complement(3519911..3520411) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /label="ywgA gene" downshifts complement(3519914) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" /label="downshifts" CDS complement(3520447..3521748) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" /label="ywfO CDS" gene complement(3520447..3521748) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /label="ywfO gene" promotor_-10 complement(3521772..3521791) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3521786) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3521788..3521909) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3521807..3521809) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3521910..3522134) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" /label="ywzC CDS" gene complement(3521910..3522134) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /label="ywzC gene" S_feature complement(3522135..3522219) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3522208..3522227) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3522218) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3522242..3522245) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3522285..3522291 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3522306..3522317 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3522307 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="upshifts" CDS 3522349..3523125 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" /label="psrF CDS" gene 3522349..3523125 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /label="psrF gene" downshifts 3523111 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" /label="downshifts" promotor_-35 3523213..3523220 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3523235..3523254 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3523239..3527465 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3523239 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3523269..3524159) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" /label="ywfM CDS" gene complement(3523269..3524159) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /label="ywfM gene" promotor_no_box complement(3524159..3524259) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3524199) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3524327..3525172) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" /label="lipL CDS" gene complement(3524327..3525172) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /label="lipL gene" downshifts complement(3524490) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" /label="downshifts" CDS complement(3525221..3526120) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" /label="cysL CDS" gene complement(3525221..3526120) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /label="cysL gene" promotor_-10 complement(3526163..3526182) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3526166) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3526196..3526203) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3526267) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3526267..3527238) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" /label="pta CDS" gene complement(3526267..3527238) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /label="pta gene" promotor_-10 complement(3527273..3527292) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3527298) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3527308..3527312) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3527386..3527397) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3527389) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3527411..3527417) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3527460..3527479 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3527467 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3527508..3528272 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" /label="hemQ CDS" gene 3527508..3528272 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /label="hemQ gene" downshifts 3528259 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3528335..3528341 /Source="Nicolas_upshift_promotors" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3528355..3528374 /Source="Nicolas_upshift_promotors" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3528364 /Source="Nicolas_upshifts" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3528405..3529184 /gene="bacG" /locus_tag="BSU_37680" /old_locus_tag="BSU37680" /EC_number="1.3.1.-" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:12372825, 20052993, 23519407, 25644640" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 20052993, 23519407, 25644640; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclohexenol-containing tetrahydro-4-hydroxyphenylpyruvate H(4)HPP in bacilysin synthesis" /protein_id="NP_391648.1" /db_xref="EnsemblGenomes-Gn:BSU37680" /db_xref="EnsemblGenomes-Tr:CAB15795" /db_xref="GOA:P39644" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3U49" /db_xref="PDB:3U4C" /db_xref="PDB:3U4D" /db_xref="SubtiList:BG10632" /db_xref="UniProtKB/Swiss-Prot:P39644" /translation="MSKRTAFVMGASQGIGKAIALKLADQHFSLVINSRNLDNIESVK EDILAKHPEASVIVLAGDMSDQHTRAGIFQKIESQCGRLDVLINNIPGGAPDTFDNCN IEDMTATFTQKTVAYIDAIKRASSLMKQNEFGRIINIVGNLWKEPGANMFTNSMMNAA LINASKNISIQLAPHNITVNCLNPGFIATDRYHQFVENVMKKNSISKQKAEEQIASGI PMKRVGSAEETAALAAFLASEEASYITGQQISADGGSMKSI*" /label="bacG CDS" gene 3528405..3529184 /gene="bacG" /locus_tag="BSU_37680" /old_locus_tag="BSU37680" /label="bacG gene" downshifts 3529161 /Source="Nicolas_upshifts" /id="D1955" /incds=0 /nref=84 /ntot=226 /MaxReadThrough="3.12719" /MaxDrop="4.87473" /score="3.07615905" /energy="-11.9" /TU="U2965" /idTUdmin="U2964" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3529199..3530398) /gene="bacF" /locus_tag="BSU_37690" /old_locus_tag="BSU37690" /function="16.4: Excrete" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 12670965, 15609023, 20052993, 18957859, 19061923, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 12670965, 15609023, 20052993, 18957859, 19061923, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanine aminotransferase forming tetrahydrotyrosine in bacilysin synthesis" /protein_id="NP_391649.1" /db_xref="EnsemblGenomes-Gn:BSU37690" /db_xref="EnsemblGenomes-Tr:CAB15796" /db_xref="GOA:P39643" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10631" /db_xref="UniProtKB/Swiss-Prot:P39643" /translation="MEITPSDVIKTLPRQEFSLVFQKVKEMEKTGAHIINLGQGNPDL PTPPHIVEALREASLNPSFHGYGPFRGYPFLKEAIAAFYKREYGVTINPETEVALFGG GKAGLYVLTQCLLNPGDIALVPNPGYPEYLSGITMARAELYEMPLYEENGYLPDFEKI DPAVLEKAKLMFLNYPNNPTGAVADAAFYAKAAAFAKEHNIHLIHDFAYGAFEFDQKP ASFLEAEDAKTVGAELYSFSKTFNMAGWRMAFAVGNEKIIQAVNEFQDHVFVGMFGGL QQAASAALSGDPEHTESLKRIYKERIDFFTALCEKELGWKMEKPKGTFYVWAEIPNTF ETSHQFSDYLLEHAHVVVTPGEIFGSNGKRHVRISMVSKQEDLREFVTRIQKLNLPFG SLQETSR*" /label="bacF CDS" gene complement(3529199..3530398) /gene="bacF" /locus_tag="BSU_37690" /old_locus_tag="BSU37690" /label="bacF gene" CDS complement(3530399..3531583) /gene="bacE" /locus_tag="BSU_37700" /old_locus_tag="BSU37700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 15849754, 16850406, 18957859, 19061923, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 15849754, 16850406, 18957859, 19061923, 25261512, 25472439, 26284661; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux protein for bacilysin excretion, self-protection against bacilysin" /protein_id="NP_391650.1" /db_xref="EnsemblGenomes-Gn:BSU37700" /db_xref="EnsemblGenomes-Tr:CAB15797" /db_xref="GOA:P39642" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR022324" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10630" /db_xref="UniProtKB/Swiss-Prot:P39642" /translation="MKQLKPNSKYLLYGQALSFMGDYCVLPALLILSTYYHDYWVTSG VIVVRSIPMVFQPFLGVLVDRLDRIKIMLWTDIIRGIIFLGLTFLPKGEYPLIFLALL FITYGSGVFFNPARLAVMSSLESDIKSINTLFAKATTISIIVGAAAGGLFLLGGSVEL AVAFNGVTYLVSAFFISRIKLQFVPIQSENIKEAFQSFKEGLKEIKTNSFVLNAMFTM ITMALLWGVVYSYFPIVSRFLGDGEIGNFILTFCIGFGGFIGAALVSKWGFNNNRGLT YFTVLSIVSLALFLFTPIFAVSVIAAILFFIAMEYGEVLAKVKVQENAANQIQGRIFS VAEASIGLCISIGSMFINILSAPVIMGLIVVIVCGLFLHTKLVNKSFLERDNKTEQKG VF*" /label="bacE CDS" gene complement(3530399..3531583) /gene="bacE" /locus_tag="BSU_37700" /old_locus_tag="BSU37700" /label="bacE gene" CDS complement(3531580..3532998) /gene="bacD" /locus_tag="BSU_37710" /old_locus_tag="BSU37710" /EC_number="6.3.2.49" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15609023, 16030213, 18957859, 19061923, 22298000, 22407814, 24702628, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15609023, 16030213, 18957859, 19061923, 22298000, 22407814, 24702628, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine-anticapsin ligase" /protein_id="NP_391651.1" /db_xref="EnsemblGenomes-Gn:BSU37710" /db_xref="EnsemblGenomes-Tr:CAB15798" /db_xref="GOA:P39641" /db_xref="InterPro:IPR011761" /db_xref="PDB:3VMM" /db_xref="PDB:3WNZ" /db_xref="PDB:3WO0" /db_xref="PDB:3WO1" /db_xref="SubtiList:BG10629" /db_xref="UniProtKB/Swiss-Prot:P39641" /translation="MERKTVLVIADLGGCPPHMFYKSAAEKYNLVSFIPRPFAITASH AALIEKYSVAVIKDKDYFKSLADFEHPDSIYWAHEDHNKPEEEVVEQIVKVAEMFGAD AITTNNELFIAPMAKACERLGLRGAGVQAAENARDKNKMRDAFNKAGVKSIKNKRVTT LEDFRAALEEIGTPLILKPTYLASSIGVTLITDTETAEDEFNRVNDYLKSINVPKAVT FEAPFIAEEFLQGEYGDWYQTEGYSDYISIEGIMADGEYFPIAIHDKTPQIGFTETSH ITPSILDEEAKKKIVEAAKKANEGLGLQNCATHTEIKLMKNREPGLIESAARFAGWNM IPNIKKVFGLDMAQLLLDVLCFGKDADLPDGLLDQEPYYVADCHLYPQHFKQNGQIPE TAEDLVIEAIDIPDGLLKGDTEIVSFSAAAPGTSVDLTLFEAFNSIAAFELKGSNSQD VAESIRQIQQHAKLTAKYVLPV*" /label="bacD CDS" gene complement(3531580..3532998) /gene="bacD" /locus_tag="BSU_37710" /old_locus_tag="BSU37710" /label="bacD gene" CDS complement(3533017..3533778) /gene="bacC" /locus_tag="BSU_37720" /old_locus_tag="BSU37720" /EC_number="1.1.1.385" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 18957859, 19061923, 23317005, 25261512, 25472439, 26284661, 28158843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 18957859, 19061923, 23317005, 25261512, 25472439, 26284661, 28158843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroanticapsin 7-dehydrogenase" /protein_id="NP_391652.2" /db_xref="EnsemblGenomes-Gn:BSU37720" /db_xref="EnsemblGenomes-Tr:CAB15799" /db_xref="GOA:P39640" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="PDB:5ITV" /db_xref="PDB:5ITW" /db_xref="SubtiList:BG10628" /db_xref="UniProtKB/Swiss-Prot:P39640" /translation="MNLTDKTVLITGGASGIGYAAVQAFLGQQANVVVADIDEAQGEA MVRKENNDRLHFVQTDITDEAACQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELS DWNKVLQVNLTGMFLMSKHALKHMLAAGKGNIINTCSVGGLVAWPDIPAYNASKGGVL QLTKSMAVDYAKHQIRVNCVCPGIIDTPLNEKSFLENNEGTLEEIKKEKAKVNPLLRL GKPEEIANVMLFLASDLSSYMTGSAITADGGYTAQ*" /label="bacC CDS" gene complement(3533017..3533778) /gene="bacC" /locus_tag="BSU_37720" /old_locus_tag="BSU37720" /label="bacC gene" CDS complement(3533781..3534488) /gene="bacB" /locus_tag="BSU_37730" /old_locus_tag="BSU37730" /EC_number="5.3.3.19" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 14697267, 15609023, 15628860, 18957859, 19061923, 19776011, 20445239, 22483065, 22765234, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 14697267, 15609023, 15628860, 18957859, 19061923, 19776011, 20445239, 22483065, 22765234, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-((4R)-4-hydroxycyclohexa-1, 5-dien-1-yl)-2-oxopropanoate isomerase" /protein_id="NP_391653.1" /db_xref="EnsemblGenomes-Gn:BSU37730" /db_xref="EnsemblGenomes-Tr:CAB15800" /db_xref="GOA:P39639" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:3H7J" /db_xref="PDB:3H7Y" /db_xref="PDB:3H9A" /db_xref="SubtiList:BG10627" /db_xref="UniProtKB/Swiss-Prot:P39639" /translation="MKTKEDMQELYFPTPKLIEWENGVRQYSTVRGDTEVLMSYVPPH TNVEPHQHKEVQIGMVVSGELMMTVGDVTRKMTALESAYIAPPHVPHGARNDTDQEVI AIDIKRLKADETYTSPEDYFLDIFKTRDLLPGMEVTFFVEDWVEIMLAKIPGNGGEMP FHKHRNEQIGICIGGGYDMTVEGCTVEMKFGTAYFCEPREDHGAINRSEKESKSINIF FPPRYNRAKAKKMKADE*" /label="bacB CDS" gene complement(3533781..3534488) /gene="bacB" /locus_tag="BSU_37730" /old_locus_tag="BSU37730" /label="bacB gene" misc_feature complement(3534384..3534385) /Source="Nicolas_upshift_promotors" /id="U2966" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.346653346653347" /xcortree=314 /SigmaFactorBS="cgaaattaattgaatgggaaaacggagtgaggcagtattcaa ccgtacgaggggatactgAAgtattaatgtcttacgtcccgccgcataccaatgttga a" /listShort="bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3534385) /Source="Nicolas_upshifts" /id="U2966" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.346653346653347" /xcortree=314 /SigmaFactorBS="cgaaattaattgaatgggaaaacggagtgaggcagtattcaa ccgtacgaggggatactgAAgtattaatgtcttacgtcccgccgcataccaatgttga a" /listShort="bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3534478..3535092) /gene="bacA" /locus_tag="BSU_37740" /old_locus_tag="BSU37740" /EC_number="4.1.1.100" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 19776011, 18957859, 19061923, 20052993, 20863139, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 19776011, 18957859, 19061923, 20052993, 20863139, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate decarboxylase" /protein_id="NP_391654.1" /db_xref="EnsemblGenomes-Gn:BSU37740" /db_xref="EnsemblGenomes-Tr:CAB15801" /db_xref="GOA:P39638" /db_xref="SubtiList:BG10626" /db_xref="UniProtKB/Swiss-Prot:P39638" /translation="MIILDNSIQTKKRTDSLSKLITVNTLGPEGTSSEYAAKHFISNF TLLQGLNSKLSLHDTFESCIERTLQSPLEYTIVPHAYDGIKHFYMRPDLQLLQIFRCD TPMYGLAVRPDFEFRDDMLDTSVIVSHPSPINLIKYFTRKDVRFKLVNSTSQAARKVK EGLYDIALTNELARQKYGLTFVKTFKSIPMSWSLFGKGDVDDEN*" /label="bacA CDS" gene complement(3534478..3535092) /gene="bacA" /locus_tag="BSU_37740" /old_locus_tag="BSU37740" /label="bacA gene" promotor_-35 3534650..3534656 /Source="Nicolas_upshift_promotors" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3534672..3534690 /Source="Nicolas_upshift_promotors" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3534683..3535294 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" upshifts 3534683 /Source="Nicolas_upshifts" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3535115..3535134) /Source="Nicolas_upshift_promotors" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3535131) /Source="Nicolas_upshifts" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3535149..3535156) /Source="Nicolas_upshift_promotors" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3535243) /Source="Nicolas_upshifts" /id="D1956" /incds=0 /nref=1 /ntot=33 /MaxReadThrough="2.28302" /MaxDrop="5.44594" /score="19.4538123" /energy="-5.1" /TU="NA" /idTUdmin="U2969" /TUdmin=902 /isTUend="FALSE" /label="downshifts" CDS complement(3535244..3536482) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" /label="ywfA CDS" gene complement(3535244..3536482) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /label="ywfA gene" promotor_-10 complement(3536524..3536543) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3536536) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3536555..3536562) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3536692..3538104) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" /label="rocC CDS" gene complement(3536692..3538104) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /label="rocC gene" downshifts complement(3536699) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3538104..3539804) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" /label="rocB CDS" gene complement(3538104..3539804) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /label="rocB gene" misc_feature complement(3538773..3538789) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3538785) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3539878..3541425) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" /label="rocA CDS" gene complement(3539878..3541425) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /label="rocA gene" downshifts complement(3539885) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3541469) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3541471..3541651) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3541472..3541490) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3541652..3542926) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" /label="rocG CDS" gene complement(3541652..3542926) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /label="rocG gene" S_feature complement(3542927..3543009) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3543009) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3543022..3543040) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3543102) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" /label="downshifts" CDS complement(3543103..3543567) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" /label="bslB CDS" gene complement(3543103..3543567) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /label="bslB gene" S_feature complement(3543568..3543678) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3543660..3543679) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3543678) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="upshifts" promotor_-35 complement(3543694..3543701) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3543889) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3543891..3544346) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" /label="spsL CDS" gene complement(3543891..3544346) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /label="spsL gene" misc_feature 3543981..3544000 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3543989 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3544339..3545190) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" /label="spsK CDS" gene complement(3544339..3545190) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /label="spsK gene" CDS complement(3545204..3546151) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" /label="spsJ CDS" gene complement(3545204..3546151) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /label="spsJ gene" CDS complement(3546151..3546891) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" /label="spsI CDS" gene complement(3546151..3546891) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /label="spsI gene" promotor_-35 3546909..3546914 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3546915 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3546916..3547935) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" /label="spsG CDS" gene complement(3546916..3547935) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /label="spsG gene" promotor_-10 3546929..3546947 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3547799..3547808 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3547821..3547836 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3547832 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3547938..3548660) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" /label="spsF CDS" gene complement(3547938..3548660) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /label="spsF gene" CDS complement(3548653..3549774) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" /label="spsE CDS" gene complement(3548653..3549774) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /label="spsE gene" CDS complement(3549774..3550643) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" /label="spsD CDS" gene complement(3549774..3550643) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /label="spsD gene" CDS complement(3550644..3551813) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" /label="spsC CDS" gene complement(3550644..3551813) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /label="spsC gene" CDS complement(3551834..3553258) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" /label="spsB CDS" gene complement(3551834..3553258) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /label="spsB gene" CDS complement(3553263..3554033) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" /label="spsA CDS" gene complement(3553263..3554033) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /label="spsA gene" promotor_-10 complement(3554068..3554087) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3554082) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3554101..3554110) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3554201..3554206 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3554222..3554240 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3554224..3554352 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3554224 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="upshifts" CDS 3554353..3554898 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" /label="gerQ CDS" gene 3554353..3554898 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /label="gerQ gene" downshifts 3554884 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3554942..3555313) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" /label="ywdK CDS" gene complement(3554942..3555313) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /label="ywdK gene" downshifts complement(3554960) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3555375..3556697) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" /label="ywdJ CDS" gene complement(3555375..3556697) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /label="ywdJ gene" CDS complement(3556717..3557034) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" /label="ywdI CDS" gene complement(3556717..3557034) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /label="ywdI gene" promotor_-10 complement(3557063..3557082) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3557074) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3557096..3557102) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3557137..3557144 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3557160..3557179 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3557163 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="upshifts" CDS 3557202..3558572 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" /label="ywdH CDS" gene 3557202..3558572 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /label="ywdH gene" CDS complement(3558597..3559274) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" /label="ung CDS" gene complement(3558597..3559274) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /label="ung gene" downshifts complement(3558611) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3559101..3559120) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3559117) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3559136..3559141) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3559288..3560094) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" /label="ywdF CDS" gene complement(3559288..3560094) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /label="ywdF gene" promotor_-10 complement(3559587..3559605) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3559601) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3559620..3559626) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3560123..3560142) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3560129) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3560158..3560165) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3560184..3560717) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" /label="ywdE CDS" gene complement(3560184..3560717) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /label="ywdE gene" CDS complement(3560765..3561400) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" /label="ywdD CDS" gene complement(3560765..3561400) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /label="ywdD gene" CDS complement(3561393..3561731) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" /label="ywzG CDS" gene complement(3561393..3561731) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /label="ywzG gene" promotor_-10 complement(3561753..3561772) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3561764) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3561787..3561794) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3561815..3561818 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3561833..3561852 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3561833 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="upshifts" CDS 3561875..3562690 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" /label="pdxK CDS" gene 3561875..3562690 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /label="pdxK gene" downshifts 3562669 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3562745) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3562780..3563028) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" /label="ywdA CDS" gene complement(3562780..3563028) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /label="ywdA gene" downshifts complement(3562800) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" /label="downshifts" upshifts complement(3563046) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3563048..3563121) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3563056..3563062) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3563122..3564561) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" /label="sacA CDS" gene complement(3563122..3564561) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /label="sacA gene" CDS complement(3564558..3565943) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" /label="sacP CDS" gene complement(3564558..3565943) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /label="sacP gene" misc_feature complement(3565962..3565971) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3565976) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3565978..3566042) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3566021..3566038) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3566042) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3566054..3566061) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3566084..3566103) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3566102) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3566117..3566124) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3566183..3566186 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3566193 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3566201..3566220 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3566245..3567015 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" /label="nirC CDS" gene 3566245..3567015 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /label="nirC gene" S_feature 3567016..3568083 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3567054..3567884) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" /label="sacT CDS" gene complement(3567054..3567884) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /label="sacT gene" downshifts complement(3567055) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3567910..3567929) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3567916) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3567924..3568226) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" /label="ywcI CDS" gene complement(3567924..3568226) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /label="ywcI gene" promotor_-35 complement(3567944..3567951) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3568227..3568365) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3568350..3568369) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3568365) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3568680..3568688 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3568699..3568717 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3568700 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="upshifts" CDS 3568756..3571176 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15205417, 15596354, 16946274, 17666034, 18689487, 25666135" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15205417, 15596354, 16946274, 17666034, 18689487, 25666135; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391688.1" /db_xref="EnsemblGenomes-Gn:BSU38090" /db_xref="EnsemblGenomes-Tr:CAB15835" /db_xref="GOA:P29141" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR025965" /db_xref="InterPro:IPR034213" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10591" /db_xref="UniProtKB/Swiss-Prot:P29141" /translation="MKKGIIRFLLVSFVLFFALSTGITGVQAAPASSKTSADLEKAEV FGDIDMTTSKKTTVIVELKEKSLAEAKEAGESQSKSKLKTARTKAKNKAIKAVKNGKV NREYEQVFSGFSMKLPANEIPKLLAVKDVKAVYPNVTYKTDNMKDKDVTISEDAVSPQ MDDSAPYIGANDAWDLGYTGKGIKVAIIDTGVEYNHPDLKKNFGQYKGYDFVDNDYDP KETPTGDPRGEATDHGTHVAGTVAANGTIKGVAPDATLLAYRVLGPGGSGTTENVIAG VERAVQDGADVMNLSLGNSLNNPDWATSTALDWAMSEGVVAVTSNGNSGPNGWTVGSP GTSREAISVGATQLPLNEYAVTFGSYSSAKVMGYNKEDDVKALNNKEVELVEAGIGEA KDFEGKDLTGKVAVVKRGSIAFVDKADNAKKAGAIGMVVYNNLSGEIEANVPGMSVPT IKLSLEDGEKLVSALKAGETKTTFKLTVSKALGEQVADFSSRGPVMDTWMIKPDISAP GVNIVSTIPTHDPDHPYGYGSKQGTSMASPHIAGAVAVIKQAKPKWSVEQIKAAIMNT AVTLKDSDGEVYPHNAQGAGSARIMNAIKADSLVSPGSYSYGTFLKENGNETKNETFT IENQSSIRKSYTLEYSFNGSGISTSGTSRVVIPAHQTGKATAKVKVNTKKTKAGTYEG TVIVREGGKTVAKVPTLLIVKEPDYPRVTSVSVSEGSVQGTYQIETYLPAGAEELAFL VYDSNLDFAGQAGIYKNQDKGYQYFDWDGTINGGTKLPAGEYYLLAYAANKGKSSQVL TEEPFTVE*" /label="vpr CDS" gene 3568756..3571176 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /label="vpr gene" upshifts 3568914 /Source="Nicolas_upshifts" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3568923..3568942 /Source="Nicolas_upshift_promotors" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3571164 /Source="Nicolas_upshifts" /id="D1968" /incds=0 /nref=7 /ntot=104 /MaxReadThrough="0.60305" /MaxDrop="5.33856" /score="26.8487936" /energy="-16.5" /TU="NA" /idTUdmin="U2993" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3571214..3572215) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " /label="ywcH CDS" gene complement(3571214..3572215) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /label="ywcH gene" S_feature complement(3572216..3572377) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3572389..3573138) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" /label="nfrAA CDS" gene complement(3572389..3573138) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /label="nfrAA gene" downshifts complement(3572422) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3573156..3573175) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3573173) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3573190..3573193) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3573244..3574425) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" /label="rodA CDS" gene complement(3573244..3574425) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /label="rodA gene" downshifts complement(3573258) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3574426..3574557) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3574551..3574566) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3574557) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="upshifts" promotor_-35 complement(3574578..3574587) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3574792..3574799 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3574810..3574920 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3574810..3574829 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3574810 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="upshifts" CDS 3574921..3575184 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" /label="ywcE CDS" gene 3574921..3575184 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /label="ywcE gene" downshifts 3575074 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3575190 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3575227..3575601) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" /label="qoxD CDS" gene complement(3575227..3575601) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /label="qoxD gene" downshifts complement(3575238) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3575603..3576217) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" /label="qoxC CDS" gene complement(3575603..3576217) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /label="qoxC gene" CDS complement(3576231..3578180) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" /label="qoxB CDS" gene complement(3576231..3578180) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /label="qoxB gene" misc_feature 3577444..3577463 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3577450 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3577874..3577974 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3577934 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3578044 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" CDS complement(3578208..3579173) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" /label="qoxA CDS" gene complement(3578208..3579173) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /label="qoxA gene" S_feature complement(3579174..3579242) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3579229..3579248) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3579242) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3579244..3579429) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3579261..3579265) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3579360..3579365 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3579381..3579399 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3579386 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3579420..3579439) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3579429) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3579431..3579540) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3579454..3579458) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3579496 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3579525..3579544) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3579540) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3579560..3579564) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3579618..3579636) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3579623..3579629 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3579635) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3579644..3579662 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3579647 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3579652..3579657) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3579689..3579934 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" /label="ywzA CDS" gene 3579689..3579934 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /label="ywzA gene" downshifts 3579916 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3580005..3581546) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" /label="galT CDS" gene complement(3580005..3581546) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /label="galT gene" downshifts complement(3580034) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3581550..3582722) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" /label="galK CDS" gene complement(3581550..3582722) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /label="galK gene" promotor_-10 complement(3582740..3582758) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3582762) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3582773..3582779) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3582803..3583186) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" /label="ywcD CDS" gene complement(3582803..3583186) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /label="ywcD gene" CDS complement(3583204..3583875) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" /label="slrC CDS" gene complement(3583204..3583875) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /label="slrC gene" promotor_-10 complement(3583897..3583916) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3583906) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3583932..3583935) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3584016..3584019 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3584034..3584053 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3584043..3584230 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3584043 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="upshifts" CDS 3584231..3584389 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" /label="slrA CDS" gene 3584231..3584389 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /label="slrA gene" S_feature 3584390..3584774 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3584755..3584760 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3584776..3584794 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3584776 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="upshifts" CDS 3584832..3585140 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" /label="vbfB CDS" gene 3584832..3585140 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /label="vbfB gene" downshifts complement(3584918) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3584922..3585022) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3584962) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3585137..3586678 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" /label="vbfA CDS" gene 3585137..3586678 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /label="vbfA gene" downshifts 3586669 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3586709..3587311) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" /label="ywbO CDS" gene complement(3586709..3587311) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /label="ywbO gene" downshifts complement(3586723) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3587312..3587593) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3587594..3588844) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" /label="efeB CDS" gene complement(3587594..3588844) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /label="efeB gene" downshifts complement(3587690) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" /label="downshifts" CDS complement(3588863..3590020) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" /label="efeM CDS" gene complement(3588863..3590020) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /label="efeM gene" misc_feature complement(3588936..3588955) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3588963) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3590017..3591462) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" /label="efeU CDS" gene complement(3590017..3591462) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /label="efeU gene" promotor_-10 complement(3591496..3591515) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3591506) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3591529..3591536) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3591619..3592287) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" /label="thiE CDS" gene complement(3591619..3592287) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /label="thiE gene" downshifts complement(3591628) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3592284..3593102) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" /label="thiM CDS" gene complement(3592284..3593102) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /label="thiM gene" CDS complement(3593110..3594015) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" /label="cidR CDS" gene complement(3593110..3594015) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /label="cidR gene" misc_feature complement(3593750..3593769) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3593761) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3594056..3594075) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3594066..3594073 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3594077) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" upshifts 3594085 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3594087..3594106 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3594091..3594098) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3594121..3594507 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" /label="cidA CDS" gene 3594121..3594507 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /label="cidA gene" CDS 3594489..3595166 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" /label="cidB CDS" gene 3594489..3595166 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /label="cidB gene" downshifts 3595138 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3595210..3595217 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3595228 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3595231..3595250 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3595270..3596469 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" /label="ywbF CDS" gene 3595270..3596469 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /label="ywbF gene" CDS 3596503..3596700 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" /label="ywbE CDS" gene 3596503..3596700 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /label="ywbE gene" downshifts 3596679 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(3596735..3597925) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" /label="rlmI CDS" gene complement(3596735..3597925) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /label="rlmI gene" downshifts complement(3596750) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" /label="downshifts" downshifts complement(3596834) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" misc_feature complement(3597949..3597968) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3597965) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3597985..3597992 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3598001 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3598006..3598025 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3598046..3598426 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" /label="glxA CDS" gene 3598046..3598426 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /label="glxA gene" downshifts 3598324 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" /label="downshifts" downshifts 3598395 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" CDS complement(3598464..3599141) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391717.1" /db_xref="EnsemblGenomes-Gn:BSU38380" /db_xref="EnsemblGenomes-Tr:CAB15864" /db_xref="InterPro:IPR024250" /db_xref="SubtiList:BG10563" /db_xref="UniProtKB/Swiss-Prot:P39585" /translation="MLDYIWLDDESPILQQVPVEYSSAALIFSPFIQMPEGWENAKRK NDYEHIYPNDNEIRGIGKAVSWKKVMSSCGFQTHAELALALMTSIGALRDEFAREDLA EVLHENINGDLYYPSEDHISNFHIPSLVKVLGANGSNRFYYAEPIVENRGVLDITEAN LRTVLDEAATELVLTDEKMDFVFMSVYDSFINVFLAKDKNIHELVERMGWEAMICDES TYISWYR*" /label="ywbB CDS" gene complement(3598464..3599141) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /label="ywbB gene" downshifts complement(3598471) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3599150..3599169) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3599175) /Source="Nicolas_upshifts" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3599181..3599187) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3599218..3600552) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8990303, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cellobiose phosphotransferase system enzyme IIC permease component" /protein_id="NP_391718.1" /db_xref="EnsemblGenomes-Gn:BSU38390" /db_xref="EnsemblGenomes-Tr:CAB15865" /db_xref="GOA:P39584" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG10562" /db_xref="UniProtKB/Swiss-Prot:P39584" /translation="MSTFTRVMEEKIMPVAGKIAGQRHLSALRDGIILTMPLIIIGSV FLILTSLPIPGYADFMASVFGNEWADKLGYPVNASFDIMAMIAAFGIAYRLAESYGVD ALSAGAISIAAFLLATPFEVPFTPHGSTESIMVGGGIPITLLGSKGLFVAMLIALFST EIYRYIIQKNIVFKMPDGVPPAVSKSFVALIPGFIIVLLVWLARLLIEMTPFQSLHNV VGDLLGTPLSILGGSLGGSLIAEFVQMLLWSCGIHGASIIGGIMAPIWYGAMDANRLA FQAGEALPSIFTTQFFQIWINVGGSGATLALVLTMLVRSRSKQMKQLGRLGIGPALFN INEPIIFGMPIVMNPLLIVPFIIAPLLTITATYIGMSTGLVARPAGIAVPWTMPPLIS GYLATGGKVSGAVMQLVNLLITCAIYYPFFRIWDHQKWREESAVESGDKNVM*" /label="ywbA CDS" gene complement(3599218..3600552) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /label="ywbA gene" misc_feature complement(3600600..3600618) /Source="Nicolas_upshift_promotors" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3600623) /Source="Nicolas_upshifts" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3600717..3600724 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3600729 /Source="Nicolas_upshifts" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3600738..3600756 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3600780..3602717 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391719.1" /db_xref="EnsemblGenomes-Gn:BSU38400" /db_xref="EnsemblGenomes-Tr:CAB15866" /db_xref="GOA:P16396" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10561" /db_xref="UniProtKB/Swiss-Prot:P16396" /translation="MKNMSCKLVVSVTLFFSFLTIGPLAHAQNSSEKEVIVVYKNKAG KETILDSDADVEQQYKHLPAVAVTADQETVKELKQDPDILYVENNVSFTAADSTDFKV LSDGTDTSDNFEQWNLEPIQVKQAWKAGLTGKNIKIAVIDSGISPHDDLSIAGGYSAV SYTSSYKDDNGHGTHVAGIIGAKHNGYGIDGIAPEAQIYAVKALDQNGSGDLQSLLQG IDWSIANRMDIVNMSLGTTSDSKILHDAVNKAYEQGVLLVAASGNDGNGKPVNYPAAY SSVVAVSATNEKNQLASFSTTGDEVEFSAPGTNITSTYLNQYYATGSGTSQATPHAAA MFALLKQRDPAETNVQLREEMRKNIVDLGTAGRDQQFGYGLIQYKAQATDSAYAAAEQ AVKKAEQTKAQIDINKARELISQLPNSDAKTALHKRLDKVQSYRNVKDAKDKVAKAEK YKTQQTVDTAQTAINKLPNGTDKKNLQKRLDQVKRYIASKQAKDKVAKAEKSKKKTDV DSAQSAIGKLPASSEKTSLQKRLNKVKSTNLKTAQQSVSAAEKKSTDANAAKAQSAVN QLQAGKDKTALQKRLDKVKKKVAAAEAKKVETAKAKVKKAEKDKTKKSKTSAQSAVNQ LKASNEKTKLQKRLNAVKPKK*" /label="epr CDS" gene 3600780..3602717 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /label="epr gene" promotor_-10 complement(3601924..3601943) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3601925) /Source="Nicolas_upshifts" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3601957..3601965) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3602707 /Source="Nicolas_upshifts" /id="D1990" /incds=0 /nref=175 /ntot=224 /MaxReadThrough="1.26567" /MaxDrop="6.00181" /score="15.6173594" /energy="-13" /TU="NA" /idTUdmin="U3021" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3602820..3602827 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3602842..3602861 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3602861 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3603073..3603080 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3603093..3603112 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3603093 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="upshifts" CDS 3603145..3604524 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" /label="sacX CDS" gene 3603145..3604524 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /label="sacX gene" S_feature complement(3604233..3605436) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3604578..3605420 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" /label="sacY CDS" gene 3604578..3605420 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /label="sacY gene" CDS complement(3605471..3606331) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" /label="gspA CDS" gene complement(3605471..3606331) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /label="gspA gene" downshifts complement(3605481) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" /label="downshifts" downshifts 3606315 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3606353..3606371) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3606371) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3606386..3606392) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3606441..3607154) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" /label="ywaF CDS" gene complement(3606441..3607154) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /label="ywaF gene" promotor_-35 3606556..3606557 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3606577..3606594 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3606579 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3607182..3607193) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3607183) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3607208..3607214) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3607229..3607235 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3607250..3607269 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3607260 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 3607305..3607820 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" /label="tyrZR CDS" gene 3607305..3607820 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /label="tyrZR gene" misc_RNA 3607821..3608027 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboYB RNA" gene 3607821..3608027 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /label="tboYB gene" downshifts 3607987 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3608069..3609310 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" /label="tyrZ CDS" gene 3608069..3609310 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /label="tyrZ gene" promotor_-35 3609401..3609409 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3609420..3609438 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3609431 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="upshifts" CDS 3609466..3610833 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" /label="eapD CDS" gene 3609466..3610833 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /label="eapD gene" downshifts 3610810 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(3610863..3611495) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" /label="relQ CDS" gene complement(3610863..3611495) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /label="relQ gene" downshifts complement(3610881) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3611531..3611546) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3611539) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3611559..3611567) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3611637..3612572) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" /label="menA CDS" gene complement(3611637..3612572) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /label="menA gene" downshifts complement(3611649) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3612316..3612325 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3612339..3612358 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3612343 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3612573..3612660) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3612643..3612662) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3612660) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3612678..3612682) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3612705..3612717) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3612705) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3612732..3612738) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3612735..3612869) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" /label="hypothetical protein CDS" gene complement(3612735..3612869) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /label="gene" promotor_-35 3612816..3612823 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3612837..3612856 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3612846 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="upshifts" S_feature 3612849..3612953 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3612948..3612957 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3612955 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3612969..3612984 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3612991) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3612993..3613007) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3613019..3613168 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" /label="ywzH CDS" gene 3613019..3613168 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /label="ywzH gene" CDS 3613186..3614697 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" /label="dltA CDS" gene 3613186..3614697 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /label="dltA gene" CDS 3614694..3615881 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" /label="dltB CDS" gene 3614694..3615881 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /label="dltB gene" CDS 3615898..3616134 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" /label="dltC CDS" gene 3615898..3616134 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /label="dltC gene" CDS 3616134..3617312 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" /label="dltD CDS" gene 3616134..3617312 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /label="dltD gene" S_feature 3617313..3617402 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3617403..3618161 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" /label="dltE CDS" gene 3617403..3618161 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /label="dltE gene" downshifts 3618129 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature complement(3618163..3619390) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3618209..3618216 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3618230..3618249 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3618243 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="upshifts" CDS 3618302..3619393 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" /label="ilvK CDS" gene 3618302..3619393 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /label="ilvK gene" downshifts 3619295 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 3619383 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3619427..3620755) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" /label="licH CDS" gene complement(3619427..3620755) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /label="licH gene" downshifts complement(3619435) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" CDS complement(3620752..3621084) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" /label="licA CDS" gene complement(3620752..3621084) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /label="licA gene" CDS complement(3621103..3622461) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" /label="licC CDS" gene complement(3621103..3622461) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /label="licC gene" CDS complement(3622477..3622785) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" /label="licB CDS" gene complement(3622477..3622785) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /label="licB gene" promotor_-10 complement(3622830..3622849) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3622846) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3622863..3622869) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3622914) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3622914..3624839) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" /label="licR CDS" gene complement(3622914..3624839) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /label="licR gene" promotor_-35 3623577..3623586 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3623600..3623619 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3623608 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3624912..3624929) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3624936) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="upshifts" promotor_-35 complement(3624944..3624951) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3625002..3625160) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" /label="yxzF CDS" gene complement(3625002..3625160) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /label="yxzF gene" downshifts complement(3625029) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3625189..3625779) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" /label="aag CDS" gene complement(3625189..3625779) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /label="aag gene" promotor_-10 complement(3625807..3625825) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3625818) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3625839..3625845) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3625848..3625854 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3625870..3625888 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3625873 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="upshifts" CDS 3625908..3627551 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" /label="katX CDS" gene 3625908..3627551 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /label="katX gene" S_feature complement(3626045..3627594) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3627546 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3627596..3627687) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3627598..3627604 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3627612 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3627619..3627638 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3627639) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" /label="downshifts" CDS 3627656..3628858 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" /label="yxlH CDS" gene 3627656..3628858 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /label="yxlH gene" S_feature complement(3627689..3628854) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3627732) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS complement(3628855..3629631) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" /label="yxlG CDS" gene complement(3628855..3629631) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /label="yxlG gene" CDS complement(3629628..3630515) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" /label="yxlF CDS" gene complement(3629628..3630515) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /label="yxlF gene" CDS complement(3630522..3630710) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" /label="yxlE CDS" gene complement(3630522..3630710) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /label="yxlE gene" CDS complement(3630707..3630913) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" /label="yxlD CDS" gene complement(3630707..3630913) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /label="yxlD gene" CDS complement(3630910..3631230) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" /label="yxlC CDS" gene complement(3630910..3631230) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /label="yxlC gene" promotor_-35 3631043..3631052 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3631065..3631084 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3631067 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3631223..3631759) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" /label="sigY CDS" gene complement(3631223..3631759) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /label="sigY gene" upshifts complement(3631787) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3631788..3631803) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3631815..3631824) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3631890..3631897 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3631911..3631930 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3631920 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="upshifts" CDS 3631971..3633344 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" /label="yxlA CDS" gene 3631971..3633344 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /label="yxlA gene" S_feature complement(3632251..3632793) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3632781..3632800) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3632793) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3632815..3632822) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3633179 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3633359..3634189) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" /label="nnrA CDS" gene complement(3633359..3634189) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /label="nnrA gene" downshifts complement(3633365) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3634208..3634226) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3634223) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3634241..3634247) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3634267) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3634269..3634288) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3634275..3636002) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" /label="cydD CDS" gene complement(3634275..3636002) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /label="cydD gene" downshifts complement(3634374) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" /label="downshifts" CDS complement(3635999..3637702) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" /label="cydC CDS" gene complement(3635999..3637702) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /label="cydC gene" CDS complement(3637702..3638718) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" /label="cydB CDS" gene complement(3637702..3638718) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /label="cydB gene" promotor_-10 complement(3638592..3638610) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3638601) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3638626..3638631) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3638702..3640108) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" /label="cydA CDS" gene complement(3638702..3640108) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /label="cydA gene" S_feature complement(3640109..3640317) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3640300..3640319) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3640317) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3640319..3640427) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3640333..3640338) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3640424..3640443) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3640439) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="upshifts" promotor_-35 complement(3640457..3640464) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3640585..3640592 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3640602 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3640607..3640625 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3640664..3642016 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" /label="cimH CDS" gene 3640664..3642016 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /label="cimH gene" S_feature complement(3641615..3644097) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3642001 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3642092..3642111 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3642098 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="upshifts" CDS 3642138..3643826 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" /label="yxkI CDS" gene 3642138..3643826 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /label="yxkI gene" promotor_-35 3643824..3643833 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3643845..3643860 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3643849 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="upshifts" CDS 3643884..3644084 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" /label="yxzE CDS" gene 3643884..3644084 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /label="yxzE gene" S_feature 3644085..3645029 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3644098..3644937) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" /label="yxkH CDS" gene complement(3644098..3644937) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /label="yxkH gene" promotor_-10 complement(3644963..3644981) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3644981) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3644994..3645001) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3644996 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(3645044..3646141) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" /label="msmX CDS" gene complement(3645044..3646141) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /label="msmX gene" downshifts complement(3645045) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3646174..3646193) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3646191) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3646193..3646261) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3646206..3646213) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3646262..3647155) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" /label="yxkF CDS" gene complement(3646262..3647155) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /label="yxkF gene" promotor_-10 complement(3647182..3647201) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3647201) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3647215..3647222) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3647229..3647234 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3647250..3647268 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3647259 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3647276..3647282 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3647297..3647315 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3647303 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="upshifts" CDS 3647339..3648796 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" /label="aldY CDS" gene 3647339..3648796 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /label="aldY gene" promotor_-10 complement(3648222..3648240) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3648237) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3648255..3648260) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3648777 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 3648821 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3648838..3649674) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" /label="gdnE CDS" gene complement(3648838..3649674) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /label="gdnE gene" downshifts complement(3648856) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" misc_RNA complement(3649751..3649853) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" /label="gdwB RNA" gene complement(3649751..3649853) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /label="gdwB gene" downshifts complement(3649777) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3649879..3649898) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3649890) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3649892..3650633) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3649912..3649918) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3649970..3649977 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3649990..3650008 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3649999 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" S_feature 3650009..3650094 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3650070..3650077 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3650091..3650110 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3650096 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" CDS 3650242..3650784 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" /label="yxkC CDS" gene 3650242..3650784 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /label="yxkC gene" promotor_-10 complement(3650609..3650628) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3650633) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3650642..3650651) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3650774 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" S_feature 3650819..3651141 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3650859..3651878) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" /label="galE CDS" gene complement(3650859..3651878) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /label="galE gene" downshifts complement(3650877) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3651904..3651923) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3651918) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3651938..3651941) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3651993..3652499) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" /label="yxkA CDS" gene complement(3651993..3652499) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /label="yxkA gene" promotor_-10 complement(3652505..3652524) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3652527) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3652529..3652532 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3652538..3652544) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3652547..3652566 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3652550 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="upshifts" CDS 3652629..3653504 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" /label="yxjO CDS" gene 3652629..3653504 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /label="yxjO gene" S_feature complement(3652879..3652967) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3652901) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3652927..3653027) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3652967) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="upshifts" CDS 3653582..3654055 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" /label="yxjN CDS" gene 3653582..3654055 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /label="yxjN gene" CDS 3654073..3655293 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" /label="yxjM CDS" gene 3654073..3655293 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /label="yxjM gene" CDS 3655280..3655936 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" /label="yxjL CDS" gene 3655280..3655936 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /label="yxjL gene" promotor_-35 3655934..3655939 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3655953..3655972 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3655956 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="upshifts" CDS 3655986..3657218 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" /label="pepT CDS" gene 3655986..3657218 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /label="pepT gene" downshifts complement(3656003) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" downshifts 3657203 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 3657264..3657273 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3657286..3657301 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3657288..3657510 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3657288 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3657467 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 3657521..3657527 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3657540..3657640 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3657540 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="upshifts" promotor_-10 3657542..3657560 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3657619..3657626 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3657640..3657658 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3657642..3657739 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3657642 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" CDS 3657740..3658003 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" /label="yxjJ CDS" gene 3657740..3658003 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /label="yxjJ gene" promotor_-35 3657767..3657770 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3657785..3657804 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3657797 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3657951 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3657995 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 3658070..3658079 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3658085 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3658091..3658106 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3658132..3658620 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" /label="yxjI CDS" gene 3658132..3658620 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /label="yxjI gene" promotor_-35 3658625..3658632 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3658646..3658665 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3658656 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3658686..3658792 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswI RNA" gene 3658686..3658792 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /label="mswI gene" downshifts 3658787 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3658875..3660008 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" /label="yxjH CDS" gene 3658875..3660008 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /label="yxjH gene" S_feature complement(3659148..3659391) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3659386..3659405) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3659395) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3659420..3659427) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3660014..3660021 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3660036..3660055 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3660042 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3660077..3660183 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswJ RNA" gene 3660077..3660183 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /label="mswJ gene" downshifts 3660130 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 3660184..3660260 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3660261..3661397 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" /label="yxjG CDS" gene 3660261..3661397 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /label="yxjG gene" downshifts 3661384 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3661450..3662223) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" /label="yxjF CDS" gene complement(3661450..3662223) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /label="yxjF gene" downshifts complement(3661460) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3662240..3662890) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" /label="scoB CDS" gene complement(3662240..3662890) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /label="scoB gene" CDS complement(3662887..3663603) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" /label="scoA CDS" gene complement(3662887..3663603) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /label="scoA gene" CDS complement(3663627..3665045) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" /label="yxjC CDS" gene complement(3663627..3665045) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /label="yxjC gene" promotor_-10 complement(3664213..3664231) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3664232) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3664247..3664252) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3665046..3665130) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3665114..3665132) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3665130) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3665148..3665153) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3665199..3666047) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" /label="rlmA CDS" gene complement(3665199..3666047) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /label="rlmA gene" downshifts complement(3665209) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(3666048..3666233) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3666222..3666241) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3666233) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3666235..3666960) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3666257..3666261) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3666395..3666402 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3666415..3666434 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3666424 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3666434..3666536 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswB RNA" gene 3666434..3666536 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /label="gswB gene" S_feature 3666537..3666640 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3666612..3666618 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3666632..3666643 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3666642 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="upshifts" CDS 3666663..3667856 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" /label="nupG CDS" gene 3666663..3667856 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /label="nupG gene" promotor_-10 complement(3666947..3666965) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3666963) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3666978..3666985) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3667632 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3667852 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3667898..3668326) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" /label="yxiTc CDS" gene complement(3667898..3668326) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo /label="yxiTc gene" CDS complement(3668327..3668569) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" /label="yxiTn CDS" gene complement(3668327..3668569) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo /label="yxiTn gene" S_feature complement(3668570..3668633) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3668622..3668637) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3668633) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3668649..3668658) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3668666 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(3668714..3669004) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" /label="yxiS CDS" gene complement(3668714..3669004) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /label="yxiS gene" downshifts complement(3668720) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3669029..3669048) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3669046) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3669054..3671114) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" /label="katE CDS" gene complement(3669054..3671114) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /label="katE gene" promotor_-35 complement(3669062..3669069) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3671143..3671161) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3671147) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3671176..3671182) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3671207..3671212 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3671226 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3671228..3671246 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3671240..3671314 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3671315..3672595 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" /label="citH CDS" gene 3671315..3672595 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /label="citH gene" S_feature 3672596..3672735 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3672692 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3672753..3673481) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" /label="bglS CDS" gene complement(3672753..3673481) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /label="bglS gene" downshifts complement(3672770) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3673512..3673531) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3673523) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3673545..3673552) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3673669..3673776) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3673712) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" /label="downshifts" CDS complement(3673777..3674610) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" /label="licT CDS" gene complement(3673777..3674610) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /label="licT gene" promotor_-10 complement(3674641..3674660) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3674660) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3674674..3674681) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3674706..3675386) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" /label="yxiP CDS" gene complement(3674706..3675386) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /label="yxiP gene" promotor_-10 complement(3675433..3675452) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3675442) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="upshifts" promotor_-35 complement(3675466..3675473) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3675534..3675537 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3675552..3675571 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3675552 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="upshifts" CDS 3675593..3676879 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" /label="yxiO CDS" gene 3675593..3676879 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /label="yxiO gene" promotor_-10 complement(3676324..3676342) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3676332) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3676356..3676363) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3676850 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3676898..3678337) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" /label="deaD CDS" gene complement(3676898..3678337) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /label="deaD gene" downshifts complement(3676921) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" /label="downshifts" misc_feature complement(3678361..3678380) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3678378) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3678419..3679567) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" /label="yxiM CDS" gene complement(3678419..3679567) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /label="yxiM gene" promotor_-10 complement(3679594..3679610) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3679610) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3679612..3679696) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3679625..3679630) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3679697..3679885) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" /label="yxzI CDS" gene complement(3679697..3679885) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo /label="yxzI gene" CDS complement(3679916..3680047) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " /label="yxzJ CDS" gene complement(3679916..3680047) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /label="yxzJ gene" CDS complement(3680059..3680520) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" /label="yxiK CDS" gene complement(3680059..3680520) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /label="yxiK gene" CDS complement(3680536..3680832) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" /label="yxiJ CDS" gene complement(3680536..3680832) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /label="yxiJ gene" CDS complement(3680860..3681348) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" /label="yxiI CDS" gene complement(3680860..3681348) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /label="yxiI gene" CDS complement(3681366..3681818) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" /label="yxzG CDS" gene complement(3681366..3681818) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /label="yxzG gene" S_feature complement(3681819..3681887) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3681888..3682217) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" /label="yxiH CDS" gene complement(3681888..3682217) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /label="yxiH gene" S_feature complement(3682218..3682339) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3682340..3682756) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" /label="yxiG CDS" gene complement(3682340..3682756) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /label="yxiG gene" CDS complement(3682807..3683175) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" /label="yxzC CDS" gene complement(3682807..3683175) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /label="yxzC gene" CDS complement(3683169..3683639) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" /label="yxiF CDS" gene complement(3683169..3683639) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /label="yxiF gene" S_feature complement(3683640..3683964) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3683965..3684393) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" /label="wapI CDS" gene complement(3683965..3684393) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /label="wapI gene" CDS complement(3684455..3691459) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" /label="wapA CDS" gene complement(3684455..3691459) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /label="wapA gene" misc_feature 3691466..3691480 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3691480 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3691490..3691509) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3691505) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3691524..3691531) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3691621..3692556) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" /label="yxxF CDS" gene complement(3691621..3692556) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /label="yxxF gene" downshifts complement(3691842) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(3692557..3692677) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3692708..3693154) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" /label="yxiE CDS" gene complement(3692708..3693154) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /label="yxiE gene" downshifts complement(3692722) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3693191..3693210) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3693198) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3693224..3693231) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3693257..3694666) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" /label="bglH CDS" gene complement(3693257..3694666) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /label="bglH gene" CDS complement(3694689..3696518) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" /label="bglP CDS" gene complement(3694689..3696518) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /label="bglP gene" promotor_no_box complement(3696510..3696610) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3696550) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="upshifts" S_feature complement(3696552..3696744) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3696725..3696744) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3696744) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3696746..3696879) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3696757..3696764) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3696901..3697209) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" /label="yxxE CDS" gene complement(3696901..3697209) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /label="yxxE gene" downshifts complement(3696924) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" /label="downshifts" CDS complement(3697255..3697698) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" /label="rtbE CDS" gene complement(3697255..3697698) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /label="rtbE gene" CDS complement(3697695..3699404) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" /label="rtbD CDS" gene complement(3697695..3699404) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /label="rtbD gene" misc_feature complement(3698566..3698585) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3698574) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="upshifts" CDS complement(3699424..3699693) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" /label="yxiC CDS" gene complement(3699424..3699693) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /label="yxiC gene" CDS complement(3699705..3700070) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" /label="yxiB CDS" gene complement(3699705..3700070) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /label="yxiB gene" S_feature complement(3700071..3700136) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3700123..3700142) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3700136) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3700157..3700160) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3700377..3701786) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" /label="abnB CDS" gene complement(3700377..3701786) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /label="abnB gene" downshifts complement(3700400) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" /label="downshifts" S_feature complement(3701787..3701896) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3701920..3702084) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" /label="yxzL CDS" gene complement(3701920..3702084) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /label="yxzL gene" promotor_-10 complement(3701969..3701987) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3701984) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3701998..3702006) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3702276..3702295) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3702292) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3702308..3702315) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3702324..3702331 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3702346..3702365 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3702349 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="upshifts" CDS 3702403..3702849 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" /label="hutP CDS" gene 3702403..3702849 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /label="hutP gene" downshifts 3702854 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" /label="downshifts" CDS 3702962..3704488 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" /label="hutH CDS" gene 3702962..3704488 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /label="hutH gene" CDS 3704485..3706143 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" /label="hutU CDS" gene 3704485..3706143 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /label="hutU gene" CDS 3706156..3707421 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" /label="hutI CDS" gene 3706156..3707421 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /label="hutI gene" CDS 3707414..3708373 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" /label="hutG CDS" gene 3707414..3708373 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /label="hutG gene" S_feature 3708374..3708448 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3708449..3709876 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" /label="hutM CDS" gene 3708449..3709876 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /label="hutM gene" downshifts 3709872 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3709920..3711221) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" /label="pdp CDS" gene complement(3709920..3711221) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /label="pdp gene" downshifts complement(3709937) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3711251..3712432) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" /label="nupC CDS" gene complement(3711251..3712432) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /label="nupC gene" S_feature complement(3712433..3712512) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3712513..3713184) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" /label="deoC CDS" gene complement(3712513..3713184) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /label="deoC gene" promotor_-35 3713133..3713136 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3713151 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3713152..3713171 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3713212..3713231) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3713227) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3713245..3713252) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3713290..3714231) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" /label="deoR CDS" gene complement(3713290..3714231) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /label="deoR gene" promotor_-10 complement(3714276..3714295) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3714282) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3714284..3714364) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3714311..3714314) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3714365..3715192) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391823.2" /db_xref="EnsemblGenomes-Gn:BSU39440" /db_xref="EnsemblGenomes-Tr:CAB15980" /db_xref="GOA:P39139" /db_xref="InterPro:IPR009597" /db_xref="SubtiList:BG10981" /db_xref="UniProtKB/Swiss-Prot:P39139" /translation="MAVKDRYMSKIKQETKPWIKRFGRLGYFAFGGVFILLGVLAFMT AAGAGRAKDSSGALQTLSRMPYGSLLLFFIGIGLIGYVIWMVLSAIKDTEGHGNSRRG LSRRIGNFFSAAVYTSIAWNALRFVFGQGDGGTSEQTWSAYVLAQPFGQWLTGLTGAG FIVFAIVQFMKGVRAAFMKEFDTSKMNKQMICITKNTGRAGNIARAIIFSAIGYFLIK TAMTADPDDTRGFDGALAELAQQPHGKLILSILALGLILYGMYAIMKGIYQHMTWEK* " /label="yxxB CDS" gene complement(3714365..3715192) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /label="yxxB gene" downshifts complement(3715164) /Source="Nicolas_upshifts" /id="D2045" /incds=0 /nref=6 /ntot=96 /MaxReadThrough="4.46865" /MaxDrop="3.48502" /score="14.6805498" /energy="-16" /TU="U3109,U3111" /idTUdmin="U3111" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3715217..3715235) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3715230) /Source="Nicolas_upshifts" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3715249..3715255) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3715265..3716377) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1860825, 10746760, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ethanolamine permease" /protein_id="NP_391824.1" /db_xref="EnsemblGenomes-Gn:BSU39450" /db_xref="EnsemblGenomes-Tr:CAB15981" /db_xref="GOA:P54957" /db_xref="InterPro:IPR007441" /db_xref="SubtiList:BG11894" /db_xref="UniProtKB/Swiss-Prot:P54957" /translation="MTVNDAVVFILAAFLLWGAADYCLGNRWGLGERFADGFKAMGPL ALSMIGIVSLAPVLAAILIPIVAPFYTAIGADPSSFANTILAIDMGGYALAGEMAKDP QAGLFSWVFLGTMMGPAIVFTIPVALGIIEKEDHPYFAKGILIGLCTVPIGCLIGGLC AGFDIGMIGKNLLIPSLLSAVIAFGLWRYTDRMIQLFHLFGKAVSMVAIIGLAAVSVE TMTGIVLIPGMENVETGIQTTGTIAIALAGAFPMTAFITKTFKKPLQALGKCLHLDET ATAGLVTSLAHHIPMLASLKDMTPRGKVINVAFAVSGAFVLGSHLGFVAGMKKEMAAA MIIGKLAGGVTAAAAAAWMTPAQSAKQQKRISASHS*" /label="yxeR CDS" gene complement(3715265..3716377) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /label="yxeR gene" CDS complement(3716447..3717784) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic enzyme" /protein_id="NP_391825.2" /db_xref="EnsemblGenomes-Gn:BSU39460" /db_xref="EnsemblGenomes-Tr:CAB15982" /db_xref="GOA:P54956" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11893" /db_xref="UniProtKB/Swiss-Prot:P54956" /translation="MSKQGLTAGLAEAVRTSQPEHSVDAIHEAKKGLLDFTAASFAGR EDKGIQKLLRLIEDEGGRPLVPVIGQGKKAAPLQSAMLNGFIAHALDFDDVHSDVRGH PSAVIVPALIASAARGHDERLLGAYVVGVEVMARLGESIGSRHYEKGWHNTGTLGAIA AACAVGYAEELTQEELEKAIGFAATQSAGMRVQFGTEMKPLHAGLAAQAGLLAVKLAQ SEFGGSRTALDGETGFFSLYGDVEKAQHTLLNDWGAPWRIVQPGLWFKIYPFCSAAHH AADAVRQLISEETISAANTERIEVIFPPGGDAALTERSPKAGEEGRFSVEYVIALALH GHGLTVEHFSSQPIPNGVQTTMGRIQRVYDNAIQPAPHAVPKGRFTIVRAYLSDGRIC EARVDCPKGAPGNELSEEDIIEKLTLTVPQEKARRIITAVEKADIKEFLAHIE*" /label="yxeQ CDS" gene complement(3716447..3717784) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /label="yxeQ gene" CDS complement(3717781..3718923) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-sulfur-metabolite deacetylase" /protein_id="NP_391826.2" /db_xref="EnsemblGenomes-Gn:BSU39470" /db_xref="EnsemblGenomes-Tr:CAB15983" /db_xref="GOA:P54955" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="PDB:1YSJ" /db_xref="SubtiList:BG11892" /db_xref="UniProtKB/Swiss-Prot:P54955" /translation="MADKAFHTRLINMRRDLHEHPELSFQEVETTKKIRRWLEEEQIE ILDVPQLKTGVIAEIKGREDGPVIAIRADIDALPIQEQTNLPFASKVDGTMHACGHDF HTASIIGTAMLLNQRRAELKGTVRFIFQPAEEIAAGARKVLEAGVLNGVSAIFGMHNK PDLPVGTIGVKEGPLMASVDRFEIVIKGKGGHAGIPNNSIDPIAAAGQIISGLQSVVS RNISSLQNAVVSITRVQAGTSWNVIPDQAEMEGTVRTFQKEARQAVPEHMRRVAEGIA AGYGAQAEFKWFPYLPSVQNDGTFLNAASEAAARLGYQTVHAEQSPGGEDFALYQEKI PGFFVWMGTNGTEEWHHPAFTLDEEALTVASQYFAELAVIVLETIK*" /label="sndB CDS" gene complement(3717781..3718923) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /label="sndB gene" CDS complement(3718940..3719689) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391827.1" /db_xref="EnsemblGenomes-Gn:BSU39480" /db_xref="EnsemblGenomes-Tr:CAB15984" /db_xref="GOA:P54954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11891" /db_xref="UniProtKB/Swiss-Prot:P54954" /translation="MITVKNIRKAFKDLVVLDGIDLEVKRGEVVAIIGPSGSGKSTLL RCLNLLERPDQGLIEIGEAKLNAEKFTRKEAHRLRQQTAMVFQNYNLFKNKTALQNIT EALIVAQHKPRDEAKRIGMEILKQVGLEHKADSYPITMSGGQQQRIGIARALAVNPHA ILLDEPTSALDPELVTGVLQVIKSIAEKQTTMIIVTHEMAFAKEVADQVIFMADGHII EQGTPEELFDHPKNERTKRFIKQVGEPAELI*" /label="yxeO CDS" gene complement(3718940..3719689) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /label="yxeO gene" CDS complement(3719702..3720376) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 15849754, 16513748, 16850406, 16885442; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391828.1" /db_xref="EnsemblGenomes-Gn:BSU39490" /db_xref="EnsemblGenomes-Tr:CAB15985" /db_xref="GOA:P54953" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11890" /db_xref="UniProtKB/Swiss-Prot:P54953" /translation="MNTIDWEFMISAFPTLIQALPITLFMAIAAMIFAIIGGLILALI TKNKIPVLHQLSKLYISFFRGVPTLVQLFLIYYGLPQLFPEMSKMTALTAAIIGLSLK NAAYLAEIFRAALNSVDDGQLEACLSVGMTKFQAYRRIILPQAIRNAIPATGNTFIGL LKETSLAFTLGVMEMFAQGKMYASGNLKYFETYLAVAIVYWVLTIIYSILQDLFERAM SKPYRT*" /label="yxeN CDS" gene complement(3719702..3720376) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /label="yxeN gene" CDS complement(3720399..3721193) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_391829.1" /db_xref="EnsemblGenomes-Gn:BSU39500" /db_xref="EnsemblGenomes-Tr:CAB15986" /db_xref="GOA:P54952" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11889" /db_xref="UniProtKB/Swiss-Prot:P54952" /translation="MKMKKWTVLVVAALLAVLSACGNGNSSSKEDDNVLHVGATGQSY PFAYKENGKLTGFDVEVMEAVAKKIDMKLDWKLLEFSGLMGELQTGKLDTISNQVAVT DERKETYNFTKPYAYAGTQIVVKKDNTDIKSVDDLKGKTVAAVLGSNHAKNLESKDPD KKINIKTYETQEGTLKDVAYGRVDAYVNSRTVLIAQIKKTGLPLKLAGDPIVYEQVAF PFAKDDAHDKLRKKVNKALDELRKDGTLKKLSEKYFNEDITVEQKH*" /label="yxeM CDS" gene complement(3720399..3721193) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /label="yxeM gene" promotor_-35 3720765..3720774 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3720786 /Source="Nicolas_upshifts" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3720787..3720802 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3721218..3721715) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur-containing aminoacid acetyltransferase" /protein_id="NP_391830.2" /db_xref="EnsemblGenomes-Gn:BSU39510" /db_xref="EnsemblGenomes-Tr:CAB15987" /db_xref="GOA:P54951" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11888" /db_xref="UniProtKB/Swiss-Prot:P54951" /translation="MKPRYRLAVERDAEQLLELTLRAYEPIRKLGIRFAAAHADLDLV LKNIRENACYVMEEDGRIIATITLRMPWGKQPGPYGVPHIWWFAVDPDTGKKGIGTKL LQWLEETILRDTLKVPFVSLGTADKHPWLIEMYERKGYVRSGEQDLGKGHITVYMKKQ LRHDL*" /label="snaB CDS" gene complement(3721218..3721715) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /label="snaB gene" CDS complement(3721729..3723054) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8892809, 12193636, 15294834, 16513748, 16885442, 23944997; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391831.1" /db_xref="EnsemblGenomes-Gn:BSU39520" /db_xref="EnsemblGenomes-Tr:CAB15988" /db_xref="GOA:P54950" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG11887" /db_xref="UniProtKB/Swiss-Prot:P54950" /translation="MTSKKKQIKLGVFLAGTGHHVASWRHPDAPSDASMNLDYFKELA KTAERGKLDMLFLADSLSIDSKSHPNVLTRFEPFTLLSALAQVTSKIGLTATASTTYS EPFHIARQFASLDHLSNGRAGWNVVTSSIESTALNFSGEKHLEHHLRYQRAEEFVEIV KGLWDSWEEDAFIRNKETGEFFDKEKMHELNHKGEYFSVRGPLNVSRTPQGQPVIIQA GSSGDGKALAAKTAEVIFTAQNHLESAQEFYQSIKEQAAEFGRDPEKIAIMPGIFPII ADTEEAAQAKYKELQDLIIPSVGLQILQNYLGGIDLSAYPLDGPLPKLDAEASNAVKS RFKLVQEMAERDNMTIRELYKYVAGSRGHHIFVGTPEQLADKMQEWVDTKACDGFNIM PPLLPEGIEVFVDQVVPILQERGVFRKEYEGTTLREHFGLEKPVNRYAK*" /label="yxeK CDS" gene complement(3721729..3723054) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /label="yxeK gene" promotor_-10 complement(3723131..3723150) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3723135) /Source="Nicolas_upshifts" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3723164..3723171) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3723240..3723467) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_391832.2" /db_xref="EnsemblGenomes-Gn:BSU39530" /db_xref="EnsemblGenomes-Tr:CAB15989" /db_xref="SubtiList:BG11886" /db_xref="UniProtKB/Swiss-Prot:P54949" /translation="MSLINSHQSADSGLNIWSQLFFYTIVTASEWIGGLQKRRKGKGN GEILYEIIGRKLSLCFIRLSFLADIEVALVE*" /label="yxeJ CDS" gene complement(3723240..3723467) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /label="yxeJ gene" CDS complement(3723454..3724440) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /EC_number="3.5.1.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15937167, 16511127, 18667582, 21978958" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937167, 16511127, 18667582, 21978958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin V amidase" /protein_id="NP_391833.2" /db_xref="EnsemblGenomes-Gn:BSU39540" /db_xref="EnsemblGenomes-Tr:CAB15990" /db_xref="GOA:P54948" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029132" /db_xref="PDB:2OQC" /db_xref="SubtiList:BG11885" /db_xref="UniProtKB/Swiss-Prot:P54948" /translation="MCTSLTLETADRKHVLARTMDFAFQLGTEVILYPRRYSWNSEAD GRAHQTQYAFIGMGRKLGNILFADGINESGLSCAALYFPGYAEYEKTIREDTVHIVPH EFVTWVLSVCQSLEDVKEKIRSLTIVEKKLDLLDTVLPLHWILSDRTGRNLTIEPRAD GLKVYDNQPGVMTNSPDFIWHVTNLQQYTGIRPKQLESKEMGGLALSAFGQGLGTVGL PGDYTPPSRFVRAVYLKEHLEPAADETKGVTAAFQILANMTIPKGAVITEEDEIHYTQ YTSVMCNETGNYYFHHYDNRQIQKVNLFHEDLDCLEPKVFSAKAEESIHELN*" /label="yxeI CDS" gene complement(3723454..3724440) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /label="yxeI gene" downshifts complement(3723458) /Source="Nicolas_upshifts" /id="D2046" /incds=0 /nref=7 /ntot=52 /MaxReadThrough="2.95669" /MaxDrop="3.32309" /score="23.0334771" /energy="-17.9" /TU="NA" /idTUdmin="U3113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3723591..3723600 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3723614..3723633 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3723624..3724257 /Source="Nicolas_S_feature" /locus_tag="new_4062713_4063346" /HighExp="S6, S7, S8, S5, Paraq, G150, H2O2, G180, LBGexp, Oxctl" /AntisenseName="yxeI" /AntisenseCor="0.24221971906572701" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S1520" upshifts 3723624 /Source="Nicolas_upshifts" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3724495..3724514) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3724506) /Source="Nicolas_upshifts" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3724529..3724536) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3724595..3725407) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 21575135, 23582330, 25527541, 25848029, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sugar-phosphate hydrolase (promiscuous)" /protein_id="NP_391834.1" /db_xref="EnsemblGenomes-Gn:BSU39550" /db_xref="EnsemblGenomes-Tr:CAB15991" /db_xref="GOA:P54947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11884" /db_xref="UniProtKB/Swiss-Prot:P54947" /translation="MYKLIAIDMDGTLLNDHHEVTEEVRDALHAAKAEGVKIVLCTGR PIGGVQRYLDELNLIEEGDYVIAYNGALVQNTHTNEVVSELSLGYDDLTSLYDLSLEL KTPMHFFDSSNLYTPNRDISEFTVYESYVTQVPLHFRKIDEVPKDILIPKVMFIDKPE NLSRVITSIPKDVREKYTMVRSAPFFYEILHSEASKGNAVRQLAQLLGIEQAEVMCIG DNGNDLTMIEWAGCGVAMANAIPEVLEAANFQTRSNNEHGVAHAIHELVLAK*" /label="hadM CDS" gene complement(3724595..3725407) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /label="hadM gene" promotor_-10 complement(3725437..3725456) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3725447..3726004) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391835.1" /db_xref="EnsemblGenomes-Gn:BSU39560" /db_xref="EnsemblGenomes-Tr:CAB15992" /db_xref="GOA:P54946" /db_xref="SubtiList:BG11883" /db_xref="UniProtKB/Swiss-Prot:P54946" /translation="MRNQKAERLVAAGLVLHIIQWIFILWAFLKVKHLFSDYTIYNPN VISGSMQSLSFIQMMRAMMYSGAIVNYVLFFALVLLIYGIVLHAILIVLEMAAYVMIR RNPSSSWGFFFIAAGVKLAILNITGIPFLAAGFLLMKQKKAENGVKAERKRKPRLRIR RQGRRLNRIRRKPSLPVEYQKEKTI*" /label="yxeG CDS" gene complement(3725447..3726004) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /label="yxeG gene" upshifts complement(3725460) /Source="Nicolas_upshifts" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3725471..3725478) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3725985..3726419) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:11160890, 22693626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 22693626; Product type s: structure" /codon_start=1 /transl_table=11 /product="lipocalin-like lipoprotein" /protein_id="NP_391836.1" /db_xref="EnsemblGenomes-Gn:BSU39570" /db_xref="EnsemblGenomes-Tr:CAB15993" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR021664" /db_xref="PDB:2JOZ" /db_xref="SubtiList:BG11882" /db_xref="UniProtKB/Swiss-Prot:P54945" /translation="MVIPLRNKYGILFLIAVCIMVSGCQQQKEETPFYYGTWDEGRAP GPTDGVKSATVTFTEDEVVETEVMEGRGEVQLPFMAYKVISQSTDGSIEIQYLGPYYP LKSTLKRGENGTLIWEQNGQRKTMTRIESKTGREEKDEKSKS*" /label="yxeF CDS" gene complement(3725985..3726419) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /label="yxeF gene" promotor_-35 3726444..3726453 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3726463 /Source="Nicolas_upshifts" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3726466..3726485 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3726479) /Source="Nicolas_upshifts" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3726480..3726891) /Source="Nicolas_S_feature" /locus_tag="new_4065569_4065980_c" /HighExp="Salt, H2O2, Paraq, dia15, Oxctl, Diami, Cold, G150, Lbtran, LBGexp" /AntisenseName="yxeE" /AntisenseCor="-0.602938477548701" /AntisenseRegPval="-27.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.391, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1521" promotor_-10 complement(3726485..3726499) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3726508..3726512) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3726508..3726873 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 17905812, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 17905812, 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391837.1" /db_xref="EnsemblGenomes-Gn:BSU39580" /db_xref="EnsemblGenomes-Tr:CAB15994" /db_xref="SubtiList:BG11881" /db_xref="UniProtKB/Swiss-Prot:P54944" /translation="MNPYQYYSPQLPQQEPYYSHYEYNPYPQQDVYDPYQMDRQPALE RRIAALERQNEQQSRELTRLTNEDRRQNREIARIAEQVNQLSQAVERHTRRLNRLNQR LRTVENRLNIPFTAGEGGF*" /label="cotNE CDS" gene 3726508..3726873 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /label="cotNE gene" downshifts 3726887 /Source="Nicolas_upshifts" /id="D2047" /incds=0 /nref=31 /ntot=47 /MaxReadThrough="1.46494" /MaxDrop="8.36553" /score="27.2157513" /energy="-12.2" /TU="U3115" /idTUdmin="U3115" /TUdmin="-38" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3726891..3726895) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3726891) /Source="Nicolas_upshifts" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3726893..3726979) /Source="Nicolas_S_feature" /locus_tag="new_4065982_4066068_c" /HighExp="Salt, S8, H2O2, dia15, S7, Paraq, Diami, aero, Oxctl, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1522" promotor_-10 complement(3726972..3726991) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3726979) /Source="Nicolas_upshifts" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3727005..3727012) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3727052..3727058 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3727072..3727083 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3727079 /Source="Nicolas_upshifts" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="upshifts" CDS 3727121..3727474 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26506528" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391838.2" /db_xref="EnsemblGenomes-Gn:BSU39590" /db_xref="EnsemblGenomes-Tr:CAB15995" /db_xref="SubtiList:BG11880" /db_xref="UniProtKB/Swiss-Prot:P54943" /translation="MHNTQHGLQQLNQCRQTAQQLIQQTQQSSQQYRQMLHQEQQNIQ MLQQILNHEQQAAHTIQQALHGHDMAIQKCQQVVNMCNQMQQELTGQSSVMNTNVSTL PFGQNTTFQQQSYQQ*" /label="yxeD CDS" gene 3727121..3727474 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /label="yxeD gene" downshifts 3727469 /Source="Nicolas_upshifts" /id="D2048" /incds=0 /nref=24 /ntot=55 /MaxReadThrough="0.20641" /MaxDrop="6.88486" /score="27.2157513" /energy="-12.2" /TU="NA" /idTUdmin="U3119" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(3727518..3727916) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391839.2" /db_xref="EnsemblGenomes-Gn:BSU39600" /db_xref="EnsemblGenomes-Tr:CAB15996" /db_xref="GOA:P54942" /db_xref="SubtiList:BG11879" /db_xref="UniProtKB/Swiss-Prot:P54942" /translation="MGITKRGAAWEWLHSWWMLFIFMPFAITSFFAFLFIGIKVRNRK WIMYGIIYFFIFAFGFVLPDLPGVFIVVPLWAVTIIHGFKVRPLYLIQLDVYKDHVEA RAFAEARSEAESRFHAPKQSIQDIHIRKEQ*" /label="yxeC CDS" gene complement(3727518..3727916) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /label="yxeC gene" downshifts complement(3727526) /Source="Nicolas_upshifts" /id="D2049" /incds=0 /nref=145 /ntot=243 /MaxReadThrough="1.70512" /MaxDrop="5.26494" /score="9.81431167" /energy="-12.2" /TU="NA" /idTUdmin="U3120" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3727931..3727950) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3727947) /Source="Nicolas_upshifts" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3727965..3727968) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3728004..3728011 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3728020..3728038) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3728026..3728045 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3728035 /Source="Nicolas_upshifts" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3728035) /Source="Nicolas_upshifts" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3728054..3728059) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3728094..3729059 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 16672620, 8388528, 19254027, 23924612, 25007174; Product type t : transporter" /codon_start=1 /transl_table=11 /product="desferrioxamine-and ferrichrome-binding transporter lipoprotein (shuttle system)" /protein_id="NP_391840.2" /db_xref="EnsemblGenomes-Gn:BSU39610" /db_xref="EnsemblGenomes-Tr:CAB15997" /db_xref="GOA:P54941" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG11878" /db_xref="UniProtKB/Swiss-Prot:P54941" /translation="MKKNILLVGMLVLLLMFVSACSGTASKGSSSDSASEKTEMRTYK SPKGNVNIPAHPKRIVTDFYAGELLSVGANVVGSGSWSFDNPFLKSKLKNVKDVGDPI SVEKVMELQPDLIVVMNEENVDKLKKIAPTVVIPYNTAKNVEDTVSMFGDIAGAKDQA KSFMADFNKKAEAAKKKIAGVIDKDATFGIYENTDKGEFWVFNDNGGRGGQAVYNALG LKAPEKIEQDVIKKGEMKQLSQEVIPEYAADYMFITDYNPKGESKTLDKLENSSIWKN LDAVKHNRVFINDFDSFYPYDPISVSKQVDIITDMLIKRAEENKK*" /label="frxB CDS" gene 3728094..3729059 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /label="frxB gene" upshifts 3728487 /Source="Nicolas_upshifts" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3728494..3728512 /Source="Nicolas_upshift_promotors" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3728966 /Source="Nicolas_upshifts" /id="D2050" /incds=1 /nref=55 /ntot=191 /MaxReadThrough="6.103" /MaxDrop="4.3334" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=193 /isTUend="FALSE" /label="downshifts" downshifts 3729037 /Source="Nicolas_upshifts" /id="D2051" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="4.41732" /MaxDrop="3.7101" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=264 /isTUend="FALSE" /label="downshifts" S_feature 3729082..3729878 /Source="Nicolas_S_feature" /locus_tag="new_4068171_4068967" /HighExp="H2O2, Paraq, Lbexp, dia0, LBGexp, G150, B36, dia15, B60, GM 25" /AntisenseName="yxeA" /AntisenseCor="0.20524492145617201" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1523" CDS complement(3729100..3729447) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391841.1" /db_xref="EnsemblGenomes-Gn:BSU39620" /db_xref="EnsemblGenomes-Tr:CAB15998" /db_xref="InterPro:IPR006542" /db_xref="InterPro:IPR036166" /db_xref="PDB:3NPP" /db_xref="SubtiList:BG11877" /db_xref="UniProtKB/Swiss-Prot:P54940" /translation="MKKAMAILAVLAAAAVICGLLFFHNDVTDRFNPFIHQQDVYVQI DRDGRHLSPGGTEYTLDGYNASGKKEEVTFFAGKELRKNAYLKVKAKGKYVETWEEVK FEDMPDSVQSKLK*" /label="yxeA CDS" gene complement(3729100..3729447) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /label="yxeA gene" downshifts complement(3729113) /Source="Nicolas_upshifts" /id="D2052" /incds=0 /nref=2 /ntot=78 /MaxReadThrough="1.28842" /MaxDrop="2.99568" /score="38.5550476" /energy="-11.6" /TU="NA" /idTUdmin="U3120" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(3729461..3731329) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15849754, 15870467, 16850406, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15849754, 15870467, 16850406, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease); efflux of cationic peptides" /protein_id="NP_391842.2" /db_xref="EnsemblGenomes-Gn:BSU39630" /db_xref="EnsemblGenomes-Tr:CAB15999" /db_xref="GOA:P42424" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG11129" /db_xref="UniProtKB/Swiss-Prot:P42424" /translation="MTFLQFAYKNVTRNKRAYLAFFLSSAFSVLIFFTFAMFLFHPAL KEGYLNNIAKKGLTAAEWMIFVFSFLFVLYSVNAFLKSRNKEFGILLMQGITPGQLRK LITAENMIIGVMSIAAGIIGGFIFSKTFFTVGAYILEMDALPLYMPWKALGITACGFL LLFFFLSQFTILFVRSNTVIKLIKGTGKVKPEPKPSVLLSLFGIACLCGGYGMVLKGN VHGAEPFIILLLTVIGTYFFFSQSSIWILRALKKWKTFYLRGKNIIWVSDLVYRLKDN ARLFFIVSIISAVAFTATGVLAMYKSTVGAEESAYEMEYLSYSNNPKEQTHLKDIDHE LKTHGFTYTKDKIDVSYVRYQEGETVPPVYMISESDAAKYFHVKVNGLKEDEAVYFPG TYDRNFKNEAPDQLKLLNQKGELSDQKLSVKEVKKPLISLNAIIAVNDQTFDQLKSLG DKASLYGYSYDHWKDSLEISQSLQNEIYGNYIDVHSDFASKAGTYYDTVQLPSLSLFI GLFIAIVFFVAAASFLYFRLFTDLDEDRERYRSLAKIGLSEREMAQSVTIQLAILFFF PFVIAVMHTLFALRTLAVEGYSDVAGPLSLTIGGFFIFQLLFFLAVRSSYLKKMNK*" /label="tpeM CDS" gene complement(3729461..3731329) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /label="tpeM gene" CDS complement(3731304..3732077) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15870467, 17600057, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15870467, 17600057, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein); efflux ofcationic peptides" /protein_id="NP_391843.2" /db_xref="EnsemblGenomes-Gn:BSU39640" /db_xref="EnsemblGenomes-Tr:CAB16000" /db_xref="GOA:P42423" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11128" /db_xref="UniProtKB/Swiss-Prot:P42423" /translation="MANMLEVKHINKTYKGQVSYQALKQISFSIEEGEFTAVMGPSGS GKTTLLNIISTIDRPDSGDILINGENPHRLKRTKLAHFRRKQLGFVFQDFNLLDTLTI GENIMLPLTLEKEAPSVMEEKLHGIAAKLGIENLLNKRTFEVSGGQRQRAAIARAVIH KPSLILADEPTGNLDSKATKDVMETLQSLNRDDHVTALMVTHDPVSASYCRRVIFIKD GELFNEIYRGENRQVFYEQILDVLSMLGGNANDLSSVRL*" /label="tpeL CDS" gene complement(3731304..3732077) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /label="tpeL gene" CDS complement(3732221..3733198) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxdJ]" /protein_id="NP_391844.1" /db_xref="EnsemblGenomes-Gn:BSU39650" /db_xref="EnsemblGenomes-Tr:CAB16001" /db_xref="GOA:P42422" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11127" /db_xref="UniProtKB/Swiss-Prot:P42422" /translation="MKLFLRSHAVLILLFLLQGLFVFFYYWFAGLHSFSHLFYILGVQ LLILAGYLAYRWYKDRGVYHWLSSGQEGTDIPYLGSSVFCSELYEKQMELIRLQHQKL HETEAKLDARVTYMNQWVHQVKTPLSVINLIIQEEDEPVFEQIKKEVRQIEFGLETLL YSSRLDLFERDFKIEAVSLSELLQSVIQSYKRFFIQYRVYPKMNVCDDHQIYTDAKWL KFAIGQVVTNAVKYSAGKSDRLELNVFCDEDRTVLEVKDYGVGIPSQDIKRVFDPYYT GENGRRFQESTGIGLHLVKEITDKLNHTVDISSSPGEGTSVRFSFLTKM*" /label="tpeK CDS" gene complement(3732221..3733198) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /label="tpeK gene" CDS complement(3733195..3733884) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [TpeK(YxdK)]" /protein_id="NP_391845.1" /db_xref="EnsemblGenomes-Gn:BSU39660" /db_xref="EnsemblGenomes-Tr:CAB16002" /db_xref="GOA:P42421" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11126" /db_xref="UniProtKB/Swiss-Prot:P42421" /translation="MNKIMIVEDSEDIRGLLQNYLEKYGYQTVVAADFTAVLDVFLRE KPDVVLLDINLPAYDGYYWCRQIRQHSTSPIIFISARSGEMDQVMAIENGGDDYIEKP FSYDIVLAKIKSQIRRAYGEYAAKQGEKVVEYAGVQLFVERFELRFQDEKSELSKKES KLLEVLLERGEKVTSRDRLMEKTWDTDIFIDDNTLNVYITRLRKKLRELNAPVSIEAV RGEGYQLRAQS*" /label="tpeJ CDS" gene complement(3733195..3733884) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /label="tpeJ gene" promotor_-10 complement(3733911..3733930) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3733929) /Source="Nicolas_upshifts" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3733945..3733951) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3733992..3734864) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /EC_number="4.1.2.29" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 10658656, 11325924, 18310071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 10658656, 11325924, 18310071; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid 6-phosphate aldolase" /protein_id="NP_391846.1" /db_xref="EnsemblGenomes-Gn:BSU39670" /db_xref="EnsemblGenomes-Tr:CAB16003" /db_xref="GOA:P42420" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11125" /db_xref="UniProtKB/Swiss-Prot:P42420" /translation="MAFVSMKELLEDAKREQYAIGQFNINGLQWTKAILQAAQKEQSP VIAAASDRLVDYLGGFKTIAAMVGALIEDMAITVPVVLHLDHGSSAERCRQAIDAGFS SVMIDGSHQPIDENIAMTKEVTDYAAKHGVSVEAEVGTVGGMEDGLVGGVRYADITEC ERIVKETNIDALAAALGSVHGKYQGEPNLGFKEMEAISRMTDIPLVLHGASGIPQDQI KKAITLGHAKININTECMVAWTDETRRMFQENSDLYEPRGYLTPGIEAVEETVRSKMR EFGSAGKAAKQQVG*" /label="iolJ CDS" gene complement(3733992..3734864) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /label="iolJ gene" downshifts complement(3733996) /Source="Nicolas_upshifts" /id="D2053" /incds=0 /nref=89 /ntot=172 /MaxReadThrough="3.05314" /MaxDrop="6.87265" /score="26.7325466" /energy="-8.2" /TU="NA" /idTUdmin="U3126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3734885..3735721) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /EC_number="5.3.99.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inosose isomerase" /protein_id="NP_391847.1" /db_xref="EnsemblGenomes-Gn:BSU39680" /db_xref="EnsemblGenomes-Tr:CAB16004" /db_xref="GOA:P42419" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="PDB:1I60" /db_xref="PDB:1I6N" /db_xref="SubtiList:BG11124" /db_xref="UniProtKB/Swiss-Prot:P42419" /translation="MKLCFNEATTLENSNLKLDLELCEKHGYDYIEIRTMDKLPEYLK DHSLDDLAEYFQTHHIKPLALNALVFFNNRDEKGHNEIITEFKGMMETCKTLGVKYVV AVPLVTEQKIVKEEIKKSSVDVLTELSDIAEPYGVKIALEFVGHPQCTVNTFEQAYEI VNTVNRDNVGLVLDSFHFHAMGSNIESLKQADGKKIFIYHIDDTEDFPIGFLTDEDRV WPGQGAIDLDAHLSALKEIGFSDVVSVELFRPEYYKLTAEEAIQTAKKTTVDVVSKYF SM*" /label="iolI CDS" gene complement(3734885..3735721) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /label="iolI gene" S_feature complement(3735722..3735806) /Source="Nicolas_S_feature" /locus_tag="new_4074811_4074895_c" /HighExp="M40t90, M0t90, BI, Sw, BC, T5.0H, T0.30H, T4.0H, T3.30H, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.101524" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1524" CDS complement(3735807..3736676) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9887260, 11566986, 12112707, 23874669; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_391848.1" /db_xref="EnsemblGenomes-Gn:BSU39690" /db_xref="EnsemblGenomes-Tr:CAB16005" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11123" /db_xref="UniProtKB/Swiss-Prot:P42418" /translation="MKLALDPSMYRDDLTLEEMVYKTAELGYEYIELSPREDFCPFYK YPKVDSAKIKQLKRLLRDTGVKLSSLLPLYHWAGPDEDRRQAAVRNWKRAIEIAVELE VDLMNSEFSGSKYDPLTSEEKFIKSMDELLPVFEKEGIKLNLQAHPYDFIETHKGAMD MIRALDKDWINLVYSTAHTFFYDDGKGDIETMFDEAGDRLTHVLFADTYNHKAAHGLR YIVNPPDAKVTVHQHLDIGQGEVDFDTIFRKLREMKFDGIATNAVFAWVDERADESSR FMLKKMKEELGLA*" /label="iolH CDS" gene complement(3735807..3736676) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /label="iolH gene" CDS complement(3736696..3737730) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /EC_number="1.1.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase" /protein_id="NP_391849.2" /db_xref="EnsemblGenomes-Gn:BSU39700" /db_xref="EnsemblGenomes-Tr:CAB16006" /db_xref="GOA:P26935" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR023794" /db_xref="InterPro:IPR036291" /db_xref="PDB:3MZ0" /db_xref="PDB:3NT2" /db_xref="PDB:3NT4" /db_xref="PDB:3NT5" /db_xref="PDB:3NTO" /db_xref="PDB:3NTQ" /db_xref="PDB:3NTR" /db_xref="PDB:4L8V" /db_xref="PDB:4L9R" /db_xref="SubtiList:BG10669" /db_xref="UniProtKB/Swiss-Prot:P26935" /translation="MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKV VEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEKPLATT AEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTV GDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETK GGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRF VAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPE FYQSFTTVQN*" /label="iolG CDS" gene complement(3736696..3737730) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /label="iolG gene" CDS complement(3737753..3739069) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="inositol transport protein" /protein_id="NP_391850.2" /db_xref="EnsemblGenomes-Gn:BSU39710" /db_xref="EnsemblGenomes-Tr:CAB16007" /db_xref="GOA:P42417" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11122" /db_xref="UniProtKB/Swiss-Prot:P42417" /translation="MGNTNGDSAFNKRTIAAALANYIDAGSIVAGSAGLSLWVSYLKL SDTQIGLLGALSANAISAAVGALLGGFLADKVGRKAVYTNSMLVYALGICLVLFGVNF PMLLSGYIIIGLSVGADITASWTIIAENAPKKNRARHCGVAQVAWAAGAVVVLLLSVL AGDLGLLGNKIVFAHLLVIALITYILRIRLPESDAWQTKNQPEEAQAEKPAVLNKTSY FDLLKPMYLKSILFLMGVYLVWNLAAGVMGFFMPYIYQQVGGVSANMANLLQMGLFIF TGLGVALIFMPFADKYRKTVFGIAAFMAVIGWTLFLLPVEGLPILLLFIVVIGINNGA GQQANYQLWASEIFPTQYRASAQGLMFFLVRISIGIWSLFVPMIITNFGIGTMAAILL GCVTASMIIGLLFAPNTSGKSLEQIQEELYGSPQSQVKKGTESKIM*" /label="iolF CDS" gene complement(3737753..3739069) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /label="iolF gene" CDS complement(3739084..3739977) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /EC_number="4.2.1.44" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 14993306, 22720735, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 14993306, 22720735, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inosose dehydratase" /protein_id="NP_391851.1" /db_xref="EnsemblGenomes-Gn:BSU39720" /db_xref="EnsemblGenomes-Tr:CAB16008" /db_xref="GOA:P42416" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR023952" /db_xref="InterPro:IPR030823" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11121" /db_xref="UniProtKB/Swiss-Prot:P42416" /translation="MGKNEILWGIAPIGWRNDDMPEIGAGNTLQHLLSDIVVARFQGT EVGGFFPEPAILNKELKLRNLRIAGKWFSSFILRDGLGEAAKTFTLHCEYLQQVNADV AVVSEQTYSVQSLEKNVFTEKPHFTDDEWERLCEGLNHLGEIAAQHGLKLVYHHHLGT GVQTAEEVDRLMAGTDPAHVHLLYDTGHAYISDGDYMGMLEKHIGRIKHVHFKDARLN VMEQCRLEGQSFRQSFLKGMFTVPGDGCIDFREVYQLLLKHSYSGWIVIEAEQDPDVA NPLEYALIARNYIDQQLLDLA*" /label="iolE CDS" gene complement(3739084..3739977) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /label="iolE gene" CDS complement(3739994..3741907) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /EC_number="3.7.1.22" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase" /protein_id="NP_391852.2" /db_xref="EnsemblGenomes-Gn:BSU39730" /db_xref="EnsemblGenomes-Tr:CAB16009" /db_xref="GOA:P42415" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR023757" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR030817" /db_xref="SubtiList:BG11120" /db_xref="UniProtKB/Swiss-Prot:P42415" /translation="MGKKIRLTTAQALIKFLNQQYIHVDGKEEPFVEGIFTIFGHGNV LGIGQALEQDAGHLKVYQGKNEQGMAHAAMAYSKQMLRRKIYAVSTSVGPGAANLVAA AGTALANNIPVLLIPADTFATRQPDPVLQQMEQEYSAAITTNDALKPVSRYWDRITRP EQLMSSLLRAFEVMTDPAKAGPATICISQDVEGEAYDFDESFFVKRVHYIDRMQPSER ELQGAAELIKSSKKPVILVGGGAKYSGARDELVAISEAYNIPLVETQAGKSTVEADFA NNLGGMGITGTLAANKAARQADLIIGIGTRYTDFATSSKTAFDFDKAKFLNINVSRMQ AYKLDAFQVVADAKVTLGKLHGLLEGYESEFGTTIRELKDEWLAERERLSKVTFKREA FDPEIKNHFSQEVLNEYADALNTELPQTTALLTINETIPEDSVIICSAGSLPGDLQRL WHSNVPNTYHLEYGYSCMGYEVSGTLGLKLAHPDREVYSIVGDGSFLMLHSELITAIQ YNKKINVLLFDNSGFGCINNLQMDHGSGSYYCEFRTDDNQILNVDYAKVAEGYGAKTY RANTVEELKAALEDAKKQDVSTLIEMKVLPKTMTDGYDSWWHVGVAEVSEQESVQKAY EAKEKKLESAKQY*" /label="iolD CDS" gene complement(3739994..3741907) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /label="iolD gene" CDS complement(3741940..3742917) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /EC_number="2.7.1.92" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid kinase" /protein_id="NP_391853.1" /db_xref="EnsemblGenomes-Gn:BSU39740" /db_xref="EnsemblGenomes-Tr:CAB16010" /db_xref="GOA:P42414" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR022841" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="InterPro:IPR030830" /db_xref="SubtiList:BG11119" /db_xref="UniProtKB/Swiss-Prot:P42414" /translation="MKYTFNEEKAFDIVAIGRACIDLNAVEYNRPMEETMTFSKYVGG SPANIAIGSAKLGLKAGFIGKIPDDQHGRFIESYMRKTGVDTTQMIVDQDGHKAGLAF TEILSPEECSILMYRDDVADLYLEPSEVSEDYIANAKMLLVSGTALAKSPSREAVLKA VQYAKKHQVKVVFELDYRPYTWQSSDETAVYYSLVAEQSDIVIGTRDEFDVMENRTGG SNEESVNHLFGHSADLVVIKHGVEGSYAYSKSGEVFRAQAYKTKVLKTFGAGDSYASA FIYGLVSGKDIETALKYGSASASIVVSKHSSSEAMPTAEEIEQLIEAQS*" /label="iolC CDS" gene complement(3741940..3742917) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /label="iolC gene" CDS complement(3742941..3743756) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /EC_number="5.3.1.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-deoxy-D-glucuronic acid isomerase" /protein_id="NP_391854.2" /db_xref="EnsemblGenomes-Gn:BSU39750" /db_xref="EnsemblGenomes-Tr:CAB16011" /db_xref="GOA:P42413" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR023770" /db_xref="InterPro:IPR024203" /db_xref="SubtiList:BG11118" /db_xref="UniProtKB/Swiss-Prot:P42413" /translation="MSYLLRKPQSHEVSNGVKLVHEVTTSNSDLTYVEFKVLDLASGS SYTEELKKQEICIVAVTGKITVTDHESTFENIGTRESVFERKPTDSVYISNDRAFEIT AVSDARVALCYSPSEKQLPTKLIKAEDNGIEHRGQFSNKRTVHNILPDSDPSANSLLV VEVYTDSGNWSSYPPHKHDQDNLPEESFLEETYYHELDPGQGFVFQRVYTDDRSIDET MTVGNENVVIVPAGYHPVGVPDGYTSYYLNVMAGPTRKWKFYNDPAHEWILER*" /label="iolB CDS" gene complement(3742941..3743756) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /label="iolB gene" S_feature complement(3743757..3743830) /Source="Nicolas_S_feature" /locus_tag="new_4082846_4082919_c" /HighExp="M40t90, M0t90, Lbtran, BI, Mt0, T0.30H, Sw, BC, S1, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1525" CDS complement(3743831..3745294) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /EC_number="1.2.1.27" /EC_number="1.2.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylmalonate-semialdehyde dehydrogenase" /protein_id="NP_391855.1" /db_xref="EnsemblGenomes-Gn:BSU39760" /db_xref="EnsemblGenomes-Tr:CAB16012" /db_xref="GOA:P42412" /db_xref="InterPro:IPR010061" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR023510" /db_xref="PDB:1T90" /db_xref="SubtiList:BG11117" /db_xref="UniProtKB/Swiss-Prot:P42412" /translation="MAEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKE DIDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEAL GEVGRGIENVEFAAGAPSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPC WMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEH PEIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAA FGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKR TLSYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIR VKNLKEAIEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFS GWKSSFFGTLHANGKDSVDFYTRKKVVTARYPAPDFN*" /label="iolA CDS" gene complement(3743831..3745294) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /label="iolA gene" S_feature complement(3745295..3745499) /Source="Nicolas_S_feature" /locus_tag="new_4084384_4084588_c" /HighExp="M0t90, M40t90, Lbtran, BI, Mt0, T0.30H, BC, S1, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1526" promotor_-35 3745298..3745305 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-35" promotor_-10 3745321..3745340 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-10" upshifts 3745328 /Source="Nicolas_upshifts" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="upshifts" S_feature 3745335..3745641 /Source="Nicolas_S_feature" /locus_tag="new_4084424_4084730" /HighExp="G180, Paraq, G150, Oxctl, H2O2, G135, Diami, LBGexp, dia5, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.788" /TUlongSig="NA" /TUlongPSig="NA" /label="S1527" promotor_-10 complement(3745481..3745500) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3745499) /Source="Nicolas_upshifts" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3745501..3745653) /Source="Nicolas_S_feature" /locus_tag="new_4084590_4084742_c" /HighExp="M40t90, M0t90, Lbtran, Diami, Heat, dia5, C30, BI, S1, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1528" promotor_-35 complement(3745515..3745522) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3745601..3745608 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-35" promotor_-10 3745623..3745642 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-10" upshifts 3745643 /Source="Nicolas_upshifts" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="upshifts" promotor_-10 complement(3745654..3745673) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-10" upshifts complement(3745670) /Source="Nicolas_upshifts" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="upshifts" promotor_-35 complement(3745689..3745696) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-35" CDS 3745710..3746465 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 11807058, 18310071, 24878601, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 11807058, 18310071, 24878601, 26735940; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the iol operon (DeoR family)" /protein_id="NP_391856.1" /db_xref="EnsemblGenomes-Gn:BSU39770" /db_xref="EnsemblGenomes-Tr:CAB16013" /db_xref="GOA:P46337" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11364" /db_xref="UniProtKB/Swiss-Prot:P46337" /translation="MKLMRIQEMEEYILSHGTVSLDELCQVFNVSKNTVRRDINKLTE KGAIEKVYGGVTSIEKTALVPFENRTIQHQDEKTKIAHYASRFIEDHDLVFIDSGTTT KSILDTLDPAKNVTILTNSLDIINAASALKNINLIIIGNNYKRKTRSFVGMDDPAMLD KYNINKAFMSATGTTLTHGLTNSDLLEYEIKKRISEKAKEVYLLADHSKFGKSTLLTY APFDRLHCIVTSQPLDDEYTQYCNEHQIGIHLA*" /label="iolR CDS" gene 3745710..3746465 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /label="iolR gene" promotor_-35 3746444..3746450 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3746465..3746484 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3746479 /Source="Nicolas_upshifts" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3746519..3747451 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9226270, 15019785, 22720735, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_391857.1" /db_xref="EnsemblGenomes-Gn:BSU39780" /db_xref="EnsemblGenomes-Tr:CAB16014" /db_xref="GOA:P46336" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PYF" /db_xref="PDB:1PZ0" /db_xref="SubtiList:BG11363" /db_xref="UniProtKB/Swiss-Prot:P46336" /translation="MKKAKLGKSDLQVFPIGLGTNAVGGHNLYPNLNEETGKELVREA IRNGVTMLDTAYIYGIGRSEELIGEVLREFNREDVVIATKAAHRKQGNDFVFDNSPDF LKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEMKKAGKIRSIGVSNFSLE QLKEANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTED TTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDIL IPGAKRADQLIDNIKTADVTLSQEDISFIDKLFA*" /label="iolS CDS" gene 3746519..3747451 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /label="iolS gene" downshifts 3747453 /Source="Nicolas_upshifts" /id="D2054" /incds=0 /nref=154 /ntot=259 /MaxReadThrough="4.521" /MaxDrop="7.17874" /score="39.70215" /energy="-17.1" /TU="U3129" /idTUdmin="U3127" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-35 3747530..3747537 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3747551..3747570 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3747557..3747712 /Source="Nicolas_S_feature" /locus_tag="new_4086646_4086801" /HighExp="dia5, LPhT, Diami, Etha, dia15, LBGstat, M9-stat, Lbtran, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.835, 0.994" /TUlongSig="SigA" /TUlongPSig="0.99" /label="S1529" upshifts 3747557 /Source="Nicolas_upshifts" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3747713..3748363 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391858.1" /db_xref="EnsemblGenomes-Gn:BSU39790" /db_xref="EnsemblGenomes-Tr:CAB16015" /db_xref="GOA:P46335" /db_xref="SubtiList:BG11362" /db_xref="UniProtKB/Swiss-Prot:P46335" /translation="MKLKYVKALVAVTVALGVLLPSTISHAKSFSGRSSSSYSSRSSS SSYSGSYKSSPKSSYSSGSSSSSKKSKTSDDSSSSISLKKKPSEKASSSSSKKSSGTF SGATSKVTGKTYSGKTSKAYVGGRYVSVNHYYHAGFAPSGWFGYYSGFTMGMFMISMM HPWGYTYHPVGGPGYVSYGASPIAWIVDIIALIIILIIVIALIRAFKAPKTYRRRF*" /label="yxcE CDS" gene 3747713..3748363 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /label="yxcE gene" CDS 3748367..3748675 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391859.1" /db_xref="EnsemblGenomes-Gn:BSU39800" /db_xref="EnsemblGenomes-Tr:CAB16016" /db_xref="InterPro:IPR020516" /db_xref="SubtiList:BG11361" /db_xref="UniProtKB/Swiss-Prot:P46334" /translation="MRLILNEQEIVDGICVYISNEEDIYPEDVEVKELSYNKRTGFFA EATFGLHHKQLMSDDISEGIIQFLEEYHNFNPDVTVVELQFDKKKGFSALVFVNEAEE *" /label="yxcD CDS" gene 3748367..3748675 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /label="yxcD gene" downshifts 3748677 /Source="Nicolas_upshifts" /id="D2055" /incds=0 /nref=185 /ntot=262 /MaxReadThrough="1.91541" /MaxDrop="6.4314" /score="14.1581732" /energy="-8.8" /TU="NA" /idTUdmin="U3130" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 3748819..3748825 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3748841..3748859 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3748851 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="upshifts" CDS 3748913..3750298 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" /label="csbC CDS" gene 3748913..3750298 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /label="csbC gene" downshifts 3750284 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 3750329..3750879 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3750340..3752220) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" /label="htpG CDS" gene complement(3750340..3752220) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /label="htpG gene" downshifts complement(3750346) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" S_feature complement(3752221..3752318) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3752309..3752328) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3752318) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3752343..3752350) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3752388..3752639) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" /label="yxcA CDS" gene complement(3752388..3752639) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /label="yxcA gene" downshifts complement(3752406) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" misc_feature complement(3752661..3752680) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3752670) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="upshifts" promotor_-35 3752703..3752709 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3752723..3752741 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3752724 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="upshifts" CDS 3752756..3753577 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" /label="yxbG CDS" gene 3752756..3753577 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /label="yxbG gene" downshifts 3753561 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" /label="downshifts" CDS complement(3753606..3754748) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" /label="yxbF CDS" gene complement(3753606..3754748) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /label="yxbF gene" downshifts complement(3753616) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3754749..3754848) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3754836..3754855) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3754847) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3754869..3754876) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3754891..3756228 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" /label="aldX CDS" gene 3754891..3756228 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /label="aldX gene" S_feature complement(3755633..3756233) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3756267..3756746) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " /label="yxbD CDS" gene complement(3756267..3756746) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /label="yxbD gene" downshifts complement(3756278) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3756826..3757818) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" /label="yxbC CDS" gene complement(3756826..3757818) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /label="yxbC gene" downshifts complement(3756850) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" /label="downshifts" downshifts 3757808 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3757841..3757860) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3757859) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3757875..3757882) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3757881..3757888 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3757902..3758326 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3757902 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3757903..3757922 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3757908..3758320 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="srlX RNA" gene 3757908..3758320 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /label="srlX gene" upshifts complement(3757928) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3757938..3757952) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3757960..3757964) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3758292 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" /label="downshifts" CDS 3758327..3759061 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" /label="yxbB CDS" gene 3758327..3759061 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /label="yxbB gene" CDS 3759061..3759330 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" /label="yxbA CDS" gene 3759061..3759330 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /label="yxbA gene" CDS 3759334..3759816 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" /label="yxnB CDS" gene 3759334..3759816 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /label="yxnB gene" CDS 3759837..3762080 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" /label="asnH CDS" gene 3759837..3762080 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /label="asnH gene" CDS 3762077..3763276 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" /label="yxaM CDS" gene 3762077..3763276 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /label="yxaM gene" promotor_-10 complement(3763032..3763050) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3763054) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3763065..3763071) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3763267 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts complement(3763340) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3763340..3764572) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" /label="yxaL CDS" gene complement(3763340..3764572) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /label="yxaL gene" promotor_-10 complement(3764604..3764623) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3764616) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3764637..3764642) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3764673..3765098) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" /label="yxaJ CDS" gene complement(3764673..3765098) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /label="yxaJ gene" promotor_-10 complement(3765126..3765145) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3765140) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3765158..3765164) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3765290..3765297 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3765307 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3765312..3765331 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3765355..3765810 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" /label="yxaI CDS" gene 3765355..3765810 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /label="yxaI gene" downshifts 3765748 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" S_feature 3765811..3766424 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3765840..3767048) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" /label="yxaH CDS" gene complement(3765840..3767048) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /label="yxaH gene" downshifts complement(3765867) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" /label="downshifts" S_feature complement(3767049..3767155) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3767156..3768169) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" /label="qdoI CDS" gene complement(3767156..3768169) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /label="qdoI gene" S_feature complement(3768170..3768243) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3768228..3768247) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3768243) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3768260..3768267) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3768263..3768838) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" /label="qdoR CDS" gene complement(3768263..3768838) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /label="qdoR gene" downshifts complement(3768287) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3768867..3768886) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3768881) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3768901..3768908) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3768909..3768915 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3768930..3768948 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3768937 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="upshifts" CDS 3768969..3770039 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" /label="yxnA CDS" gene 3768969..3770039 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /label="yxnA gene" downshifts 3770037 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3770096..3770527) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" /label="yxaD CDS" gene complement(3770096..3770527) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /label="yxaD gene" promotor_-35 3770557..3770564 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3770578..3770597 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3770587..3770753 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3770587 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3770639..3770658) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3770659) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3770673..3770680) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3770754..3771158 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" /label="yxzK CDS" gene 3770754..3771158 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /label="yxzK gene" S_feature complement(3770775..3771827) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3771128..3771820 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" /label="yxaC CDS" gene 3771128..3771820 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /label="yxaC gene" CDS complement(3771860..3772891) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" /label="yxaB CDS" gene complement(3771860..3772891) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /label="yxaB gene" downshifts complement(3771872) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-35 3772858..3772861 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3772874 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3772878..3772897 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3772928..3772946) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3772946) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3772961..3772967) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3772984..3774132) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" /label="glxK CDS" gene complement(3772984..3774132) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /label="glxK gene" promotor_-10 complement(3774171..3774190) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3774182) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3774201..3774208) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3774254..3774261 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3774275..3774294 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3774282 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3774328..3775059 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" /label="gntR CDS" gene 3774328..3775059 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /label="gntR gene" CDS 3775052..3776593 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" /label="gntK CDS" gene 3775052..3776593 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /label="gntK gene" CDS 3776622..3777968 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" /label="gntP CDS" gene 3776622..3777968 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /label="gntP gene" promotor_-35 3777421..3777425 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3777441..3777460 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3777450 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3777991..3779397 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" /label="gntZ CDS" gene 3777991..3779397 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /label="gntZ gene" downshifts 3779386 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3779494..3779513 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3779496..3779787 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3779496 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="upshifts" promotor_-35 3779760..3779767 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3779782..3779801 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3779789 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3779811..3779818 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3779833..3779852 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3779836) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3779839..3779853) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3779848 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3779861..3779865) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3779861..3780424 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" /label="ahpC CDS" gene 3779861..3780424 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /label="ahpC gene" CDS 3780438..3781967 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" /label="ahpF CDS" gene 3780438..3781967 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /label="ahpF gene" downshifts complement(3781794) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" /label="downshifts" downshifts 3781960 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3781993..3782076) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3782036) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3782077..3783516) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" /label="bglA CDS" gene complement(3782077..3783516) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /label="bglA gene" CDS complement(3783530..3783760) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" /label="ptsJ CDS" gene complement(3783530..3783760) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /label="ptsJ gene" S_feature complement(3783761..3783972) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3783969..3783988) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3783974) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3784003..3784010) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3784036..3784043 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3784054..3784073 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3784069 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="upshifts" CDS 3784104..3784814 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" /label="yydK CDS" gene 3784104..3784814 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /label="yydK gene" CDS 3784842..3785000 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" /label="yyzN CDS" gene 3784842..3785000 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /label="yyzN gene" downshifts 3785077 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3785131..3785853) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" /label="liaM CDS" gene complement(3785131..3785853) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /label="liaM gene" downshifts complement(3785143) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-35 3785754..3785757 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3785773..3785777 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3785788 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3785874..3786503) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" /label="liaL CDS" gene complement(3785874..3786503) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /label="liaL gene" S_feature complement(3786504..3786652) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3786653..3787411) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" /label="liaK CDS" gene complement(3786653..3787411) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /label="liaK gene" promotor_-10 complement(3787101..3787120) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3787117) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3787133..3787140) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3787392..3788351) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" /label="liaE CDS" gene complement(3787392..3788351) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /label="liaE gene" downshifts 3788340 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3788387..3788390 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3788395 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3788409..3788558) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" /label="liaD CDS" gene complement(3788409..3788558) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /label="liaD gene" downshifts complement(3788416) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" /label="downshifts" misc_feature 3788467..3788484 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3788472 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3788553 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3788579..3788598) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3788600) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3788613..3788620) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3788893..3788900 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3788915..3788934 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3788919 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="upshifts" CDS 3789030..3790955 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" /label="fbp CDS" gene 3789030..3790955 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /label="fbp gene" S_feature 3790956..3792320 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" S_feature complement(3791168..3791488) /Source="Nicolas_S_feature" /locus_tag="new_4130257_4130577_c" /HighExp="Cold, C30, M/G, S8, Fru, nit, Glu, BMM, Heat, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1545" CDS complement(3791489..3793249) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative DNA wielding protein" /protein_id="NP_391900.1" /db_xref="EnsemblGenomes-Gn:BSU40200" /db_xref="EnsemblGenomes-Tr:CAB16057" /db_xref="InterPro:IPR018760" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11477" /db_xref="UniProtKB/Swiss-Prot:Q45598" /translation="MIVMIIKNLFVCNSQEILKEYKFNAVGVNIILGEKREDHEETNG VGKSTMIECISFLLGKTISNFYTTNEILLNKNVFIVLNVEIDGNQVFLARSFNSPKHG YTLHDTSLTFNLEEWKKVSISVYKKFIEKEILKGEKEDITFAALREYIIRDEKTGFND IVLPNRGGLKQYKLLNYLFTLPTHTEKNIKVFRDKIEKLNSEIKLIESMNINIGDLKV KEDELINEIEDYNRVIYQTKTANKYNNDTNRYSEIKSELNKIQNEIFENEHICKQYQR NIDDLNKKVTKIKELENIEKFYEDIVGFFPEEVKQNYNKVQEFYNFMVESRGSYFKDK IVKIQADLKKLNIKKQGLTEQLESSARILKSNNFIEDISIVMEEQRRKEIELAEVRLR ISDYDKKNHIFDKINELQHEILRVNSMYYDEFQSYSAIVSELKKLFNNLMDVTYNQHG FLDFEYDNRISNAKQSTTGRIKISCSIPDERSHGRLHMKINIFDLTWFLYRCINKCSL NILIHDGSYSNPDPHVKGTLLKHINSSLLENRIGQYFVTINKNELLLDDLQELESKGM IVAKLDRNNEDKNRFFGFRF*" /label="yydD CDS" gene complement(3791489..3793249) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /label="yydD gene" downshifts complement(3791532) /Source="Nicolas_upshifts" /id="D2081" /incds=0 /nref=11 /ntot=199 /MaxReadThrough="4.99391" /MaxDrop="4.47843" /score="7.49162587" /energy="-10.5" /TU="U3167" /idTUdmin="U3167" /TUdmin="-322" /isTUend="FALSE" /label="downshifts" misc_feature 3792317..3792318 /Source="Nicolas_upshift_promotors" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3792322 /Source="Nicolas_upshifts" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3793249..3793647) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391901.1" /db_xref="EnsemblGenomes-Gn:BSU40210" /db_xref="EnsemblGenomes-Tr:CAB16058" /db_xref="SubtiList:BG11476" /db_xref="UniProtKB/Swiss-Prot:Q45599" /translation="MIDLKIETAENILKYSYVLLENEFKNIQIGNDLIPLVNNSPLKK EKAERPEMNHFLLTKYNAVEENILYSSKILYELLEKEKHIDQLFLDYAKSQGIIINLN IERILYLSLTFLYSLGKVSFNQNMISRTES*" /label="yydC CDS" gene complement(3793249..3793647) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /label="yydC gene" CDS complement(3793640..3795085) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphohydrolase" /protein_id="NP_391902.1" /db_xref="EnsemblGenomes-Gn:BSU40220" /db_xref="EnsemblGenomes-Tr:CAB16059" /db_xref="GOA:Q45600" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11475" /db_xref="UniProtKB/Swiss-Prot:Q45600" /translation="MKVRFLQISDLHFQFQNYDTIVMRDKLLDFIEVLRRESDFDFLL LTGDIAHKGDVYNEDVKEYLNGIIKSMGLSKNNVHLVPGNHDISRDMTRTLLIDSIMK SPNPSEMLDKLDQKATNILVEGQRKFFDFYEDFMGVKYPEEDLHFLYQSEKYNVLSIN TCLLSDKKGEEGTLLTAQMKLYKAIRKMNKEKNKGKVLNIAIGHHTLGCIESSERESI KAHFDDYFIDLYLAGHVHDSSFNITANTNENPFLELVSGAIIKDEYATPEFISVDVNL DNGETEVTYYIWNTEYKYWSKNNQGGRRLQEGKLNYKINRLESLIEKEIEDNDDKIDE DEFKSFIIDFHEYRESYKTFTSNFDNQIGLDKKFYDMKSGETFKRKFDSYSEYFGVIN HIMDSTSYVSADKKELIAETIVDKYLEFHNQYNNGDEIFVKIVNEIYLECHSVLPYSK ALTKKYIKILTCWCIYECEIFNDNKRSVKND*" /label="yydB CDS" gene complement(3793640..3795085) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /label="yydB gene" promotor_-35 3794335..3794342 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3794354..3794373 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3794364..3795413 /Source="Nicolas_S_feature" /locus_tag="new_4133453_4134502" /HighExp="C30, Salt, Gly, S8, Etha, LPhT, T0.30H, Heat, C90, M9-stat" /AntisenseName="yydB" /AntisenseCor="0.36202116146901597" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.431" /TUlongSig="NA" /TUlongPSig="NA" /label="S1546" upshifts 3794364 /Source="Nicolas_upshifts" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3795086..3795346) /Source="Nicolas_S_feature" /locus_tag="new_4134175_4134435_c" /HighExp="Cold, M0t90, Lbtran, M40t90, Lbstat, T0.30H, MG 150, M40t45, Gly, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1547" CDS complement(3795347..3795826) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /EC_number="2.1.1.177" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18755835, 20817755, 22411911, 22720735, 28428565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (pseudouridine1915-N3)-methyltransferase" /protein_id="NP_391903.1" /db_xref="EnsemblGenomes-Gn:BSU40230" /db_xref="EnsemblGenomes-Tr:CAB16060" /db_xref="GOA:Q45601" /db_xref="InterPro:IPR003742" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1TO0" /db_xref="SubtiList:BG11474" /db_xref="UniProtKB/Swiss-Prot:Q45601" /translation="MNINIVTIGKLKEKYLKQGIEEYTKRLSAYAKIDIIELPDEKAP ENLSDQDMKIIKDKEGDRILSKISPDAHVIALAIEGKMKTSEELADTIDKLATYGKSK VTFVIGGSLGLSDTVMKRADEKLSFSKMTFPHQLMRLILVEQIYRAFRINRGEPYHK* " /label="rlmH CDS" gene complement(3795347..3795826) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /label="rlmH gene" S_feature complement(3795827..3795906) /Source="Nicolas_S_feature" /locus_tag="new_4134916_4134995_c" /HighExp="dia5, LBGtran, T0.30H, Diami, Cold, M0t90, dia0, M0t45, M40t45, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1548" CDS complement(3795907..3796077) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097800.1" /db_xref="EnsemblGenomes-Gn:BSU40239" /db_xref="EnsemblGenomes-Tr:CAX52715" /db_xref="InterPro:IPR025626" /db_xref="UniProtKB/Swiss-Prot:C0H3T9" /translation="MKQAYYSCEEHIETVLDMYIDDHELPPEIRKIEHTNSLSTACEL CGDPAVYIVGNE*" /label="yyzF CDS" gene complement(3795907..3796077) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /label="yyzF gene" promotor_-10 complement(3796118..3796137) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3796134) /Source="Nicolas_upshifts" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3796151..3796156) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3796200..3796207 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3796220..3796239 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3796237 /Source="Nicolas_upshifts" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="upshifts" CDS 3796262..3796675 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21911367; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391904.1" /db_xref="EnsemblGenomes-Gn:BSU40240" /db_xref="EnsemblGenomes-Tr:CAB16061" /db_xref="SubtiList:BG11472" /db_xref="UniProtKB/Swiss-Prot:Q45603" /translation="MRFRWVWLFVIMLLLAECQPSYWVLEKDRIGEGSPDLEIYANYL QMHDDVKGYQVFTISEGKKMVVVSLGSSEKDKKLEVSDVKFSSKETIVTVERKPAPTA NEKNPFILIGLDKIEGDLIVQDETGDRFEETDYQQ*" /label="yycS CDS" gene 3796262..3796675 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /label="yycS gene" downshifts 3796655 /Source="Nicolas_upshifts" /id="D2082" /incds=0 /nref=17 /ntot=131 /MaxReadThrough="1.50241" /MaxDrop="5.73792" /score="16.0382598" /energy="-10.8" /TU="NA" /idTUdmin="U3168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3796709..3797935) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18820069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_391905.1" /db_xref="EnsemblGenomes-Gn:BSU40250" /db_xref="EnsemblGenomes-Tr:CAB16062" /db_xref="GOA:Q45604" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014184" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11471" /db_xref="UniProtKB/Swiss-Prot:Q45604" /translation="MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVN RKCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGD IVSVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYAD FQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAH SAQLLGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDC VGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIR FGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFD KGAAKKFVIDPHGTLK*" /label="yycR CDS" gene complement(3796709..3797935) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /label="yycR gene" downshifts complement(3796724) /Source="Nicolas_upshifts" /id="D2083" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="0.14321" /MaxDrop="4.77892" /score="8.82768619" /energy="-6.2" /TU="NA" /idTUdmin="U3169" /TUdmin=7 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3797958..3797976) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3797963) /Source="Nicolas_upshifts" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3797988..3797996) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3797998..3798168) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097801.1" /db_xref="EnsemblGenomes-Gn:BSU40259" /db_xref="EnsemblGenomes-Tr:CAX52716" /db_xref="GOA:C0H3U0" /db_xref="UniProtKB/Swiss-Prot:C0H3U0" /translation="MQTNRVILLAVMICLVSAITVFLLNGCKVDFLDIGGTIIGCFLG IFVVVRIQKKQS*" /label="yyzG CDS" gene complement(3797998..3798168) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /label="yyzG gene" promotor_-10 complement(3798187..3798205) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3798205) /Source="Nicolas_upshifts" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3798219..3798225) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3798273..3798521) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391906.1" /db_xref="EnsemblGenomes-Gn:BSU40260" /db_xref="EnsemblGenomes-Tr:CAB16063" /db_xref="GOA:Q45605" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG11470" /db_xref="UniProtKB/Swiss-Prot:Q45605" /translation="MGAIAVLFIVFGFPIVAGVFGIAGHFLFKRFWVAPLIVLITSLI LLVTLASGNSSFIFWVVMYTAIALVTSVATLFLRKFFE*" /label="yycQ CDS" gene complement(3798273..3798521) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /label="yycQ gene" CDS complement(3798537..3799700) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812, 16291680" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391907.2" /db_xref="EnsemblGenomes-Gn:BSU40270" /db_xref="EnsemblGenomes-Tr:CAB16064" /db_xref="InterPro:IPR011047" /db_xref="SubtiList:BG11469" /db_xref="UniProtKB/Swiss-Prot:Q45606" /translation="MKKWMITIAMLILAGIALFVFISPLKSHKTVSQQDLRNPDFLDD KEVLLYFSSSADQDAFGGGKSYALFISHDGTLSSFQMKGLELGSAKVHGDSVMLEDKN TIYTIKNGLRSHKRTYQHTGDSAGFLQNTDGFYTLYNSGYDKKGDGYRSELYRQMDGE WKKDVIPYYIRASGFHDGAIYALVPTDDGKGYQLLQIQADQKKLTYLSITEWQYREGA SVESQLAVDDQAVYVMVRGQKAHDLYQMVKINKKSGEVELHDIAEYKNDEQTIYSSMP FSFKNSFFPYDGNLYFIDGFGKVHKIDAKTGKTSIVFTLSPDKMKAEFKEITQKGSSL YFFTYTYHKPAYIEQYSLKTGKKMKEKEIGKVKDVVTPKSHLKLYDVEVMKRF*" /label="yycP CDS" gene complement(3798537..3799700) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /label="yycP gene" promotor_-10 complement(3798571..3798589) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3798579) /Source="Nicolas_upshifts" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3798601..3798609) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3799711..3800448) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_391908.1" /db_xref="EnsemblGenomes-Gn:BSU40280" /db_xref="EnsemblGenomes-Tr:CAB16065" /db_xref="SubtiList:BG11468" /db_xref="UniProtKB/Swiss-Prot:Q45607" /translation="MKLKKRVSMFLVALTMCGGLFVTPAKAVKTTNYAEEIAALQPGT TPEEIMKSASQIAKQQHVKQDVILKQFYKEITADKAEGDRLAKESGMSIMGGSSGTKK LPTSAKGNIYYTNSYTAYYNHGHVGMYSAADKIVESVPSDGVRQIAYNARDVEDNSIV QTVSVSSSQKTAAADWAVSKVGDPYSFNFVNNRNTGHDGAKNCSKLLWSAFLLKAGID IDSNGGLGVYPRDITSSSYTTTIMTIY*" /label="yycO CDS" gene complement(3799711..3800448) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /label="yycO gene" promotor_-10 complement(3800490..3800508) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3800496) /Source="Nicolas_upshifts" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3800522..3800530) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3800590..3801060) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14635137, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391909.1" /db_xref="EnsemblGenomes-Gn:BSU40290" /db_xref="EnsemblGenomes-Tr:CAB16066" /db_xref="GOA:O32293" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1ON0" /db_xref="PDB:1UFH" /db_xref="SubtiList:BG11467" /db_xref="UniProtKB/Swiss-Prot:O32293" /translation="MTIMLTPMQTEEFRSYLTYTTKHYAEEKVKAGTWLPEDAQLLSK QVFTDLLPRGLETPHHHLWSLKLNEKDIVGWLWIHAEPEHPQQEAFIYDFGLYEPYRG KGYAKQALAALDQAARSMGIRKLSLHVFAHNQTARKLYEQTGFQETDVVMSKKL*" /label="yycN CDS" gene complement(3800590..3801060) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /label="yycN gene" downshifts complement(3800603) /Source="Nicolas_upshifts" /id="D2084" /incds=0 /nref=1 /ntot=78 /MaxReadThrough="3.78599" /MaxDrop="2.94893" /score="8.04802973" /energy="-7.6" /TU="U3175" /idTUdmin="U3174" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3801061..3801131) /Source="Nicolas_S_feature" /locus_tag="new_4140150_4140220_c" /HighExp="S4, S5, S6, LoTm, S3, S7, S8, B36, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1549" promotor_-35 3801092..3801098 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3801112..3801131 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3801113..3801132) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3801113 /Source="Nicolas_upshifts" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3801131) /Source="Nicolas_upshifts" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3801133..3801408) /Source="Nicolas_S_feature" /locus_tag="new_4140222_4140497_c" /HighExp="S4, S5, S6, S7, S8, S3, B36, BT, LoTm, T5.0H" /AntisenseName="rapG" /AntisenseCor="-0.20647217228472101" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1550" promotor_-35 complement(3801147..3801154) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3801171..3802268 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391910.1" /db_xref="EnsemblGenomes-Gn:BSU40300" /db_xref="EnsemblGenomes-Tr:CAB16067" /db_xref="GOA:O32294" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11466" /db_xref="UniProtKB/Swiss-Prot:O32294" /translation="MNKIAPAEIASMLNDWYLAIKKHEVEESSRLFEEVKPLLDDMEE DQEVLAYFSLLELRHKVLLHEARGQGFQHEEPSHMNATSDMLKYYFFLFEGMYEAYKN NYDIAIGLYKDAEQYLDNIPDPIEKAEFHLKVGKLYYKLGQNIVSLNHTRQAVKTFRE ETDYKKKLASALITMSGNFTEMSQFEEAEAYLDEAIRITSELEDHFFEAQLLHNFGLL HAQSGKSEEAVSKLEEALQNDEYARSAYYYHSAYLLIRELFKIKKKEQALSYYQDVKE KLTAEPNRICEAKIDILYAIYAEGGHAETFHLCKQHMDDLLSEKEYDSVRELSILAGE RYRELELYKEAAHFFYEALQIEELIKRTEVI*" /label="rapG CDS" gene 3801171..3802268 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /label="rapG gene" promotor_-10 complement(3801399..3801417) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-10" upshifts complement(3801408) /Source="Nicolas_upshifts" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="upshifts" promotor_-35 complement(3801432..3801437) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-35" promotor_-35 3801992..3802000 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3802012..3802030 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3802025 /Source="Nicolas_upshifts" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="upshifts" CDS 3802269..3802385 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapG" /protein_id="NP_391911.1" /db_xref="EnsemblGenomes-Gn:BSU40310" /db_xref="EnsemblGenomes-Tr:CAB16068" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG11465" /db_xref="UniProtKB/Swiss-Prot:O32295" /translation="MKRFLIGAGVAAVILSGWFIADHQTHSQEMKVAEKMIG*" /label="phrG CDS" gene 3802269..3802385 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /label="phrG gene" downshifts 3802374 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3802622..3803512) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" /label="argI CDS" gene complement(3802622..3803512) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /label="argI gene" downshifts complement(3802628) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" downshifts complement(3802690) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" /label="downshifts" CDS complement(3803586..3804989) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" /label="rocE CDS" gene complement(3803586..3804989) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /label="rocE gene" S_feature complement(3804990..3805211) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3805212..3806417) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" /label="rocD CDS" gene complement(3805212..3806417) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /label="rocD gene" misc_feature complement(3806474..3806492) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3806477) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3806587..3806592 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3806607..3806626 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3806622 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="upshifts" CDS 3806658..3808043 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" /label="rocR CDS" gene 3806658..3808043 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /label="rocR gene" CDS complement(3808025..3808213) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" /label="yyzO CDS" gene complement(3808025..3808213) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo /label="yyzO gene" CDS complement(3808330..3808458) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" /label="hypothetical protein CDS" gene complement(3808330..3808458) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /label="gene" downshifts 3808382 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS complement(3808478..3809680) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" /label="htrC CDS" gene complement(3808478..3809680) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /label="htrC gene" downshifts complement(3808502) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3809712..3809723) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3809712) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3809738..3809744) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3809762..3810556) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" /label="walJ CDS" gene complement(3809762..3810556) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /label="walJ gene" CDS complement(3810578..3811420) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" /label="walI CDS" gene complement(3810578..3811420) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /label="walI gene" CDS complement(3811407..3812774) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /modified_by="User" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYTNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" /label="Delta6_BSU_40390_SNPvariant" gene complement(3811407..3812774) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /modified_by="User" /label="Delta6_BSU_40390_SNPvariant" Polymorphism join(3812001,3812003) /Source="geneious" /ID="SNP_BsDelta6_4151091_4151091" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="N -> T" /CDS_Position=773 /Change="T -> G" /Codon_Change="AAC -> ACC" /Coverage=184 /locus_tag="BSU_40390" /Protein_Effect="Substitution" /Reference_Frequency="0.5%" /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="Delta6_BSU_40390_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(3812764..3814599) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" /label="walK CDS" gene complement(3812764..3814599) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /label="walK gene" CDS complement(3814607..3815314) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" /label="walR CDS" gene complement(3814607..3815314) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /label="walR gene" S_feature complement(3815315..3815411) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3815399..3815418) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3815411) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3815413..3815605) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3815434..3815437) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3815605) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="upshifts" misc_feature complement(3815615..3815634) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3815697) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" tRNA complement(3815698..3815770) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Phe tRNA" gene complement(3815698..3815770) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /label="trnY-Phe gene" tRNA complement(3815806..3815882) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Asp tRNA" gene complement(3815806..3815882) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /label="trnY-Asp gene" S_feature complement(3815883..3815963) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3815964..3816035) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Glu tRNA" gene complement(3815964..3816035) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /label="trnY-Glu gene" tRNA complement(3816045..3816120) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Lys tRNA" gene complement(3816045..3816120) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /label="trnY-Lys gene" misc_feature 3816092..3816108 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3816105 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3816121..3816217) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3816201..3816220) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3816217) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3816234..3816241) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3816251..3816352) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3816291) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3816345..3817637) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" /label="purA CDS" gene complement(3816345..3817637) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /label="purA gene" downshifts complement(3816356) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3817677..3817696) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3817697) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3817711..3817718) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3817843..3818262) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" /label="yycE CDS" gene complement(3817843..3818262) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /label="yycE gene" promotor_-10 complement(3818260..3818271) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3818271) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3818286..3818292) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3818383..3819747) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" /label="dnaC CDS" gene complement(3818383..3819747) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /label="dnaC gene" downshifts complement(3818403) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3818447) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3819778..3819797) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3819792) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3819812..3819814) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3819859..3819865 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3819880..3819898 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3819882 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="upshifts" CDS 3819917..3820117 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" /label="yycD CDS" gene 3819917..3820117 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /label="yycD gene" downshifts 3820087 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" /label="downshifts" S_feature 3820132..3820453 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3820165..3820368) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" /label="yyzB CDS" gene complement(3820165..3820368) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /label="yyzB gene" S_feature complement(3820369..3820669) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3820434..3820437 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3820452..3820471 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3820455 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="upshifts" CDS 3820489..3820629 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" /label="yycC CDS" gene 3820489..3820629 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /label="yycC gene" S_feature 3820630..3820701 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3820677) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3820680..3820694) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3820702..3820706) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3820702..3821910 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" /label="yycB CDS" gene 3820702..3821910 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /label="yycB gene" downshifts 3821891 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3822015..3824072 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" /label="yycA CDS" gene 3822015..3824072 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /label="yycA gene" downshifts 3823937 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(3824109..3824558) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" /label="rplI CDS" gene complement(3824109..3824558) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /label="rplI gene" downshifts complement(3824123) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3824555..3826534) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" /label="gdpP CDS" gene complement(3824555..3826534) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /label="gdpP gene" misc_feature complement(3825036..3825055) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3825039) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3825452..3825459 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3825473..3825491 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3825477..3826143 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3825477 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3826571..3827500) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" /label="yybS CDS" gene complement(3826571..3827500) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /label="yybS gene" S_feature complement(3827501..3827637) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3827619..3827638) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3827637) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3827653..3827658) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3827727..3827876) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" /label="yyzH CDS" gene complement(3827727..3827876) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /label="yyzH gene" downshifts complement(3827753) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3827915..3827934) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3827932) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="upshifts" promotor_-35 complement(3827948..3827954) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3827955..3827964 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3827977..3827996 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3827983 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3827995) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3827997..3828510) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3827999..3828013) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3828022..3828026) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3828022..3828504 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" /label="cotF CDS" gene 3828022..3828504 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /label="cotF gene" downshifts 3828491 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3828534..3828911) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" /label="hypR CDS" gene complement(3828534..3828911) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /label="hypR gene" S_feature 3828536..3829065 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3828555) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3828966..3828985) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3828978) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3828999..3829006) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3829047..3829051 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3829065..3829084 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3829067 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3829092..3829106) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3829095) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3829116..3830045 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" /label="ppaC CDS" gene 3829116..3830045 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /label="ppaC gene" downshifts 3830031 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3830074) /Source="Nicolas_upshifts" /id="D2102" /incds=0 /nref=14 /ntot=136 /MaxReadThrough="1.08899" /MaxDrop="4.94065" /score="19.3488922" /energy="-11.7" /TU="NA" /idTUdmin="U3200" /TUdmin=33 /isTUend="FALSE" /label="downshifts" CDS complement(3830078..3830524) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 25794618, 25794619; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative manganese-binding lipoprotein" /protein_id="NP_391936.1" /db_xref="EnsemblGenomes-Gn:BSU40560" /db_xref="EnsemblGenomes-Tr:CAB16093" /db_xref="GOA:P37488" /db_xref="SubtiList:BG10015" /db_xref="UniProtKB/Swiss-Prot:P37488" /translation="MKIILTVLAGVGLLSAGGCGMLDQVNDGLNYTSEAAGYVEKVKT FAEEAPELAEKAVNDTEAKEKLEAQLESIQKAAADFNELTPPDAAAEIHRTIQEHNET LQKSAEDVLKQAEEGKVSLKELEQSDLVQNAKQITDVMGQIEKLGE*" /label="yybP CDS" gene complement(3830078..3830524) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /label="yybP gene" S_feature complement(3830525..3830855) /Source="Nicolas_S_feature" /locus_tag="new_4169613_4169943_c" /HighExp="S8, Cold, S7, S6, H2O2, S5, S4, Etha, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998614" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1563" misc_RNA complement(3830714..3830831) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /product="manganese ion binding riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /label="mswM RNA" gene complement(3830714..3830831) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /label="mswM gene" promotor_-10 complement(3830846..3830865) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3830854) /Source="Nicolas_upshifts" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3830879..3830886) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3830892..3830898 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3830911 /Source="Nicolas_upshifts" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3830913..3830931 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3830927..3830933 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3830948..3830959 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3830955 /Source="Nicolas_upshifts" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="upshifts" CDS 3830957..3832264 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391937.1" /db_xref="EnsemblGenomes-Gn:BSU40570" /db_xref="EnsemblGenomes-Tr:CAB16094" /db_xref="GOA:P37489" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10016" /db_xref="UniProtKB/Swiss-Prot:P37489" /translation="MTEEVFIMSQERVKRPGHTRWYISSLLSGIIILNYFDRVAISVA APAIQDSFHLTATELGIVFSIYTYSYTLMQLPVGSLLDRFGVAWVTRVGMTIWSFLTI LLAFLQGKLLLYLFRFLIGLTSASAFPAASKATALWFPPSERGLANSLFDSAAKFSNV IGAPLVAFLVTTFDWRVAFLTIGCINVLFTIFFWQYYEQPERHKRISKSELNYIQKHN AITTEQIPYKTGPLLKKLFTNRKVWGLMIGFTGYGYTFNLLLTWLPTFFKHTYGMDLM SSGLFTAVPWLISTISGIAVGGWLVDYFIKKGYPNTKVYRTVIIVGMSFGFFFLGSIL TNNITVAIICISIGLAGISATAPVGWSISAELAPIGSVSMLSSMVNLANNLFGGIIAA SLTGYLFDVTGSFTLSFLVAGFVLLLGLVFYVFVLGDVKRIKL*" /label="yybO CDS" gene 3830957..3832264 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /label="yybO gene" downshifts complement(3832065) /Source="Nicolas_upshifts" /id="D2103" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="0.73662" /MaxDrop="2.97868" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 3832253 /Source="Nicolas_upshifts" /id="D2104" /incds=0 /nref=7 /ntot=55 /MaxReadThrough="2.76545" /MaxDrop="3.99898" /score="-3.44083304" /energy="-17.9" /TU="NA" /idTUdmin="U3201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3832308..3832547) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52719.1" /translation="MNYKKQNQGFGSISGDHNDIHDILATIEENGTQDAFHYEGGLQG KNEQVLEQIEQEMLASGLDIEEQDEEKVNGDGPIL*" /label="yyzI CDS" gene complement(3832308..3832547) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /pseudo /label="yyzI gene" downshifts complement(3832329) /Source="Nicolas_upshifts" /id="D2105" /incds=0 /nref=4 /ntot=114 /MaxReadThrough="3.05613" /MaxDrop="4.69729" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3832333..3832433) /Source="Nicolas_upshift_promotors" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3832373) /Source="Nicolas_upshifts" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3832537..3832701) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52720.1" /translation="MMIRGIHLEQQLKDIISACDVAIQNEDFDTLMNYYSERIMCKPR KQPPQRFCEL*" /label="yyzJ CDS" gene complement(3832537..3832701) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /pseudo /label="yyzJ gene" CDS complement(3832713..3832898) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514014.1" /translation="MSHQTKYPVNEAAIMPSNRLFARFTMELSMDTEPIGASSAEMDQ RNRKNKNEKDPYVSNIV*" /label="hypothetical protein CDS" gene complement(3832713..3832898) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /label="gene" downshifts 3832979 /Source="Nicolas_upshifts" /id="D2106" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="0.18425" /MaxDrop="3.85413" /score="3.91893698" /energy="-13.7" /TU="NA" /idTUdmin="U3201" /TUdmin=726 /isTUend="FALSE" /label="downshifts" CDS complement(3833171..3833317) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52721.1" /translation="MYGKTIKKRLEKIAFLFQEISKKRKEKIERSFVGSKQLHGLSYR RFRG*" /label="yyzK CDS" gene complement(3833171..3833317) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /pseudo /label="yyzK gene" CDS complement(3833299..3833448) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52722.1" /translation="MLNQHTLTYSTIDRKDYRSYKSNPEICLRILHKINETPESRYSV CMAKP*" /label="yyzL CDS" gene complement(3833299..3833448) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /pseudo /label="yyzL gene" misc_feature complement(3833764..3833780) /Source="Nicolas_upshift_promotors" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3833781) /Source="Nicolas_upshifts" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3833800..3833807 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3833822..3834025 /Source="Nicolas_S_feature" /locus_tag="new_4172910_4173113" /HighExp="nit, T-3.40H, T-1.40H, T-0.40H, T0.0H, SMMPr, SMM, LoTm, ferm, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1564" promotor_-10 3833822..3833841 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3833822 /Source="Nicolas_upshifts" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3833843..3833857) /Source="Nicolas_upshift_promotors" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3833847) /Source="Nicolas_upshifts" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="upshifts" CDS 3834026..3834463 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27902860" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391938.1" /db_xref="EnsemblGenomes-Gn:BSU40580" /db_xref="EnsemblGenomes-Tr:CAB16095" /db_xref="InterPro:IPR020208" /db_xref="SubtiList:BG10017" /db_xref="UniProtKB/Swiss-Prot:P37490" /translation="MNKFLKSNFRFLLAAALGISLLASSNFIKASNDNYKFHLLVPYG YGNAYSNDAFRQTTHTDNPWKVNLQKSAEGKGTIMTFWLINTGNSKIPKASKIHNVKQ GSGAHYYHANSQGSHTYVALAVENNNYSASSYGIDGVWDEETW*" /label="yybN CDS" gene 3834026..3834463 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /label="yybN gene" S_feature 3834464..3834540 /Source="Nicolas_S_feature" /locus_tag="new_4173552_4173628" /HighExp="M9-tran, SMMPr, MG 120, aero, GM 120, SMM, T-2.40H, T-4.40H, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1565" downshifts 3834497 /Source="Nicolas_upshifts" /id="D2107" /incds=0 /nref=10 /ntot=98 /MaxReadThrough="6.91942" /MaxDrop="3.8662" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3201" /TUdmin=2244 /isTUend="FALSE" /label="downshifts" CDS 3834577..3835332 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391939.1" /db_xref="EnsemblGenomes-Gn:BSU40590" /db_xref="EnsemblGenomes-Tr:CAB16096" /db_xref="SubtiList:BG10018" /db_xref="UniProtKB/Swiss-Prot:P37491" /translation="MESHIYRIIKNKLTIIIFTIIILIPCVDISLLLMTNTEYHPAYA FFLSGTSVGHASQMILLWFLPLYFLLLCADDSIQDYKTGYHYILISKVGRKKYCLEKI FTSFIISFLTMFLSLILNFLLVQVFFFKGTFKNDLDQIKFPDNSLYTFSMAHPYIAIV LFSIICCIMSGFVGALGSSLSLLFRDKKYAYPASFFIWFVLILKNKSLMFLFQPFTEY GYNVLLPILCLSIFIFLIIISSIVLYEAKYNEN*" /label="yybM CDS" gene 3834577..3835332 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /label="yybM gene" S_feature complement(3835172..3837761) /Source="Nicolas_S_feature" /locus_tag="new_4174260_4176850_c" /HighExp="S8, S6, S4, S5, S7, S3, C30, BT, G135, T5.0H" /AntisenseName="yybK" /AntisenseCor="-0.46686696237140402" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1566" CDS 3835322..3836032 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391940.1" /db_xref="EnsemblGenomes-Gn:BSU40600" /db_xref="EnsemblGenomes-Tr:CAB16097" /db_xref="SubtiList:BG10019" /db_xref="UniProtKB/Swiss-Prot:P37492" /translation="MKIKRLLLILCLLLFLVTLWFNQNHTYLGKNSIASLLYMNNSTF GYSSIFAYTLFYIVPFLMLLSNFFHSENPYKVMRMVKRKNYYKSKIMEIGFVSLLFSS IHTVINITCTHIFFSKNLLVEANFLSICLLNMISLVFFYLSVGIMFRLTYDLFNSVAL AIFIVYIILDSLYFGVKLLLPNGYWEPFRDLAIFTNMLNRYWSTSNLIIVYIRQIIIV FIFYLVGSSIFLNKDYKK*" /label="yybL CDS" gene 3835322..3836032 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /label="yybL gene" downshifts 3835531 /Source="Nicolas_upshifts" /id="D2108" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="7.39982" /MaxDrop="2.95139" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3205" /TUdmin="-2354" /isTUend="FALSE" /label="downshifts" CDS 3836029..3836784 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391941.1" /db_xref="EnsemblGenomes-Gn:BSU40610" /db_xref="EnsemblGenomes-Tr:CAB16098" /db_xref="InterPro:IPR024295" /db_xref="SubtiList:BG10020" /db_xref="UniProtKB/Swiss-Prot:P37493" /translation="MRIKGFFITLVAIIFQASLSSYNNNKNVFPFLDGIPISTSGHYE YQNILLWFVPIVSLSFCFSGSIRDTYISYEQLKLVREHSRVKWVTSQFLIITVVLLIF TLSQIAIFYIYSLVSLHNLDINSVINKRFVMMTLMYYLTLLNLFSFQLFMELYYKSQI AQLNISVYIIFSLILAKKLVQLNSPKVIHYFLIPNYSNGLRTGLSYYSQSGTAIIEPL LGLFIIIILQISIVILSVLKFKKIDMLKSEGLQ*" /label="yybK CDS" gene 3836029..3836784 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /label="yybK gene" CDS 3836781..3837436 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1938973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-binding cassette subunit of transporter" /protein_id="NP_391942.1" /db_xref="EnsemblGenomes-Gn:BSU40620" /db_xref="EnsemblGenomes-Tr:CAB16099" /db_xref="GOA:P37494" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10021" /db_xref="UniProtKB/Swiss-Prot:P37494" /translation="MIEVLNLTKKLKRLQF*IISLIHLKKEQFMDYLGVMVLERPCYF VHYPG**SLLKGV*LLKVNNYIKISLFLKV*D*L*KICSYFLSMMLLLTLKFCQKLKR SHQIMIY*ILLVELVWKILIV*RLVNSR*E*NND*ILHRLFLKNLIYCYLMNQQMRLM KKELHLFMTFFYKRKKGELPLLLLVITRKILYLYVTLH*K*IMDV*KLQKK*YIRKIV " /label="yybJ CDS" gene 3836781..3837436 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /label="yybJ gene" S_feature 3837437..3837751 /Source="Nicolas_S_feature" /locus_tag="new_4176526_4176840" /HighExp="aero, Cold, HPh, nit, M/G, M9-tran, S1, SMM, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1567" downshifts 3837708 /Source="Nicolas_upshifts" /id="D2109" /incds=0 /nref=93 /ntot=227 /MaxReadThrough="3.45614" /MaxDrop="4.54398" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 3837752 /Source="Nicolas_upshifts" /id="D2110" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.98662" /MaxDrop="3.29879" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(3837806) /Source="Nicolas_upshifts" /id="D2111" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.53364" /MaxDrop="2.25148" /score="10.1219981" /energy="-6.3" /TU="U3207" /idTUdmin="U3209" /TUdmin=2266 /isTUend="FALSE" /label="downshifts" CDS complement(3837811..3838599) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16321932, 22882546, 25835496" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932, 22882546, 25835496; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391943.1" /db_xref="EnsemblGenomes-Gn:BSU40630" /db_xref="EnsemblGenomes-Tr:CAB16100" /db_xref="SubtiList:BG10022" /db_xref="UniProtKB/Swiss-Prot:P37495" /translation="MNVYDIRMAPYWFYEGRGLVQHPYVFRQPVSSRAIIVSTRGDVT GDGVIDEVFLTGNQMPGSPLWRNITLVIRDGRTHQEQRIQLQNNMGYNPSLFLGDMTG DKIEDVAVVMDTGGSGGAIYAYVFAYLNRQFRRIFNSDVLNDELKYSVRYQNQYKASV ISHQQNETYILDLTYKGREYLNEIYNSQGVLKMPIEGWVNPLSGLYPVDFDRDGVYEL LAYQRIAGRYNADSLGYVQTVLKWNGQRFMFNRQTVTIFGSDLS*" /label="ictI CDS" gene complement(3837811..3838599) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /label="ictI gene" promotor_-10 complement(3838623..3838641) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3838642) /Source="Nicolas_upshifts" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3838657..3838662) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3838667..3839056) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391944.1" /db_xref="EnsemblGenomes-Gn:BSU40640" /db_xref="EnsemblGenomes-Tr:CAB16101" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:2GXF" /db_xref="SubtiList:BG10023" /db_xref="UniProtKB/Swiss-Prot:P37496" /translation="MEQQLKDIISACDLAIQNEDFDTLMNYYSEDAVLVVKPGMIARG KEEIKKAFITIANYFNHHIVPTQGKMILLEAGDTVLVLSQTLLDSDKKDSEYAMERRA TYVFKKNAQGEWLCVIDNSYGTDLIGV*" /label="yybH CDS" gene complement(3838667..3839056) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /label="yybH gene" promotor_-35 3839125..3839128 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3839143..3839162 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3839156 /Source="Nicolas_upshifts" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="upshifts" CDS 3839202..3840041 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11709313, 12486061" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391945.1" /db_xref="EnsemblGenomes-Gn:BSU40650" /db_xref="EnsemblGenomes-Tr:CAB16102" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG10024" /db_xref="UniProtKB/Swiss-Prot:P37497" /translation="MSAEVTLHDNIHYDLSADCQHCFGLCCVALPYAKSADFAFDKDG GTPCRNLQSNYQCSIHKDLREKGFRGCSAYECFGAGQKVSQITYEGKDWRNSPETANQ MFDVFPIMQQLHEMLWYLHEALSIDIAKPIHSELRTTFEKIERLTRLSKERLLTLQVD EHRAEVNEWLLKTSELVRAQARHPKLPKKVSRGSVLIGAKLKGLDLRGANLRGALLIA ADLRNADLRMTDFIGADMRDADLSGADLTGSIFLTQAQVNAANGDSNTKLPLSVRTPA HWK*" /label="yybG CDS" gene 3839202..3840041 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /label="yybG gene" downshifts 3840018 /Source="Nicolas_upshifts" /id="D2112" /incds=0 /nref=35 /ntot=188 /MaxReadThrough="1.19247" /MaxDrop="3.72166" /score="-0.156630814" /energy="-6.3" /TU="NA" /idTUdmin="U3208" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3840074..3841288) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811656, 11557812, 12486061, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391946.1" /db_xref="EnsemblGenomes-Gn:BSU40660" /db_xref="EnsemblGenomes-Tr:CAB16103" /db_xref="GOA:P37498" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10025" /db_xref="UniProtKB/Swiss-Prot:P37498" /translation="MTYIRKGTPVFRKITFAFFAAGFNTFAILYCVQPLMEEFTREFH VTPTAASLSLSVTTMLLAVSMLVFGSLSEVWGRKPIMGISMLAASVLCLASAFSPSFH TLLVLRTIQGVALAGLPSIAMAYLGEEIEPGSLGSAMGLYISGNAIGAVFGRIVSGLL SEYLNWHMAMGTIGVISLIASVIFFINLPPSRHFTPRKLKLGKLGMSLIGHLRDRKLF SLFLIGFLLLGSNVALFNYIVYVLLGPPYSLNKAFSSWIFIVMIVGIFSSSFIGRMVD RYGYPKILVMNIFIVIAGALFTINNMLAVKILGIALFTFGFFGGHSVASSWVGRRALH NKAQASSLYLFFYYAGSSVFGTIGGLFWSGFHWLGVVGMITFMLLVALWLSGYLARSV KMPDKRNEKGLN*" /label="yybF CDS" gene complement(3840074..3841288) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /label="yybF gene" downshifts complement(3840092) /Source="Nicolas_upshifts" /id="D2113" /incds=0 /nref=45 /ntot=169 /MaxReadThrough="1.92237" /MaxDrop="5.70619" /score="10.1219981" /energy="-6.3" /TU="NA" /idTUdmin="U3209" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(3841289..3841392) /Source="Nicolas_S_feature" /locus_tag="new_4180378_4180481_c" /HighExp="BI, B60, ferm, T0.30H, T-1.10H, T-0.40H, T-1.40H, T1.0H, nit, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94819299999999995" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1568" promotor_-10 complement(3841385..3841404) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3841393..3841400 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3841395) /Source="Nicolas_upshifts" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3841414..3841433 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3841418..3841425) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3841426 /Source="Nicolas_upshifts" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="upshifts" CDS 3841475..3842353 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591, 17526699, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391947.2" /db_xref="EnsemblGenomes-Gn:BSU40670" /db_xref="EnsemblGenomes-Tr:CAB16104" /db_xref="GOA:P37499" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10026" /db_xref="UniProtKB/Swiss-Prot:P37499" /translation="MEWEQLEYFQTLARMQHVTKAAKSLSITQPALSRSIARLENHLG VPLFDRQGRSISLNQYGHIFLRRVQAMMKEYTEGKEEIQALLKPDQGVVSLGFLHTLG TTLVPDLIGSFQQEYPNISFQLKQNHSYWLLERLKSGDLDLCLLASIKPENPIQWIKL WSEELFVFVPNDHPLASRESITLNEIAGERFILLKKGYALRMTVDELFEKANIQPNIM FEGEEATTAAGFVAAGLGISILPDLKGLDQSKITKIRVSWPECQRVIGIAWIKGRFLS PVAETFKQYVISHFSE*" /label="yybE CDS" gene 3841475..3842353 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /label="yybE gene" CDS 3842367..3842810 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_391948.1" /db_xref="EnsemblGenomes-Gn:BSU40680" /db_xref="EnsemblGenomes-Tr:CAB16105" /db_xref="GOA:P37500" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10027" /db_xref="UniProtKB/Swiss-Prot:P37500" /translation="MNVKKITSEQDLHTAFEIRKAVFVEEQGCPISDEFDEFDTLHGD CQHILAYHQNVPVGTARVRIVGHTGKLERICILKSYRKFGLGKVIVDALERIVKEQGI SAFKLHGQTQAAGFYEKLGYRTASEEFMLDGIPHVLMTKQDDSAL*" /label="yybD CDS" gene 3842367..3842810 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /label="yybD gene" CDS 3842893..3843372 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28032445; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391949.1" /db_xref="EnsemblGenomes-Gn:BSU40690" /db_xref="EnsemblGenomes-Tr:CAB16106" /db_xref="SubtiList:BG10028" /db_xref="UniProtKB/Swiss-Prot:P37501" /translation="MPANKKEGLIFGVMMCFGMVCVMSIYNAIINRAIYDFSLMTVFE MVIGFMIALLLDLLLVGPLAKKIAFRMPFDKTKKIYVILAMSTCMVIGMVLCMSVFGL VTAVLANGLNGDSLFSAYLMIVLKNFILAYPLQLLIMGPLVRGVFMKFVKPKLTAAI* " /label="yybC CDS" gene 3842893..3843372 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /label="yybC gene" downshifts 3843362 /Source="Nicolas_upshifts" /id="D2114" /incds=0 /nref=13 /ntot=97 /MaxReadThrough="0.69144" /MaxDrop="3.55998" /score="-9.53342462" /energy="-10.9" /TU="NA" /idTUdmin="U3210" /TUdmin=1628 /isTUend="FALSE" /label="downshifts" CDS complement(3843547..3844209) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391950.1" /db_xref="EnsemblGenomes-Gn:BSU40700" /db_xref="EnsemblGenomes-Tr:CAB16107" /db_xref="GOA:P37502" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10029" /db_xref="UniProtKB/Swiss-Prot:P37502" /translation="MNLRQLSEHVFQCEFELDVPLRIPVHTWFIKDGDDVYIVDTGIE RFADAQIRAALAIGNPKAILLTHGHSDHIGGASKWLERFDIPIFAHQKELKYINGEEP YPNKNEVENTGVAHIVQPLTEQTLAHLPLKYYLTPGHSPGHVVYYHKIDRTLLTGDLF ITSKEDLHPPIRRFSVDINENIDSGSIIDQIKPTLICSSHGEEILYNEELYKNYVVRY RD*" /label="yybB CDS" gene complement(3843547..3844209) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /label="yybB gene" CDS complement(3844356..3844808) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, polyamine export and degradation)" /protein_id="NP_391951.1" /db_xref="EnsemblGenomes-Gn:BSU40710" /db_xref="EnsemblGenomes-Tr:CAB16108" /db_xref="GOA:P37503" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10030" /db_xref="UniProtKB/Swiss-Prot:P37503" /translation="MNDILREIGMIARALDSISNIEFKDLDLTRGQYLYLVRIYENPG IIQEKLAEMIKVDRTTAARAIKKLEMQGFIQKLPDEQNKKIKKLFPTEKGKKVYPLLR REGEHSTEVALSGFTSEEKETISALLHRVRKNIERDWEYVKKGNKRDY*" /label="yybA CDS" gene complement(3844356..3844808) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /label="yybA gene" promotor_-35 3844832..3844839 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3844854..3844873 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3844856 /Source="Nicolas_upshifts" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="upshifts" S_feature 3844858..3844927 /Source="Nicolas_S_feature" /locus_tag="new_4183947_4184016" /HighExp="G135, G180, H2O2, LoTm, G150, Salt, Diami, Paraq, LBGstat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1569" promotor_-10 complement(3844861..3844880) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3844863) /Source="Nicolas_upshifts" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3844893..3844900) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3844928..3845374 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase (polyamine degradation)" /protein_id="NP_391952.1" /db_xref="EnsemblGenomes-Gn:BSU40720" /db_xref="EnsemblGenomes-Tr:CAB16109" /db_xref="GOA:P37504" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10031" /db_xref="UniProtKB/Swiss-Prot:P37504" /translation="MNIKRITTEADLHEALKIRRGVFIEEQHVSEADEFDEFDTLQEQ CQHILVYHENQPVGTGRARIVGHTAKLERICILKPYRKYGLGKIIVSGLEEIMKEKGL TSYKLHGQTQAAGFYQKLGYQISSQEFMEDGIPHVLMTKEISRNIT*" /label="yyaT CDS" gene 3844928..3845374 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /label="yyaT gene" CDS 3845371..3845976 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391953.1" /db_xref="EnsemblGenomes-Gn:BSU40730" /db_xref="EnsemblGenomes-Tr:CAB16110" /db_xref="SubtiList:BG10032" /db_xref="UniProtKB/Swiss-Prot:P37505" /translation="MKYMYYGIGILILSLGISLTIQSGLGTSPFDALLVGLSKKIGLT VGSWEVLISVILLICNAILTRKKPILLGLITAFITGIGIDLWLFVVKNTIYLNSLLSK LICFGIGLVLIGLGTAIYLQTKFASTPIDHLTLIIRDLSKRTILFSRTLVYALFLVLA IIFKGPIGIGTLLTVCLGGMLLHVFMPIVERHFLSKNRRGY*" /label="yyaS CDS" gene 3845371..3845976 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /label="yyaS gene" CDS complement(3846071..3846592) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16579456, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyl-transferase" /protein_id="NP_391954.1" /db_xref="EnsemblGenomes-Gn:BSU40740" /db_xref="EnsemblGenomes-Tr:CAB16111" /db_xref="GOA:P37506" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR008125" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10033" /db_xref="UniProtKB/Swiss-Prot:P37506" /translation="MIMKMTHLNMKDFNKPNEPFVVFGRMIPAFENGVWTYTEERFSK PYFKQYEDDDMDVSYVEEEGKAAFLYYLENNCIGRIKIRSNWNGYALIEDIAVAKDYR KKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGAVDTMLYSNFP TANEIAIFWYYKF*" /label="yyaR CDS" gene complement(3846071..3846592) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /label="yyaR gene" S_feature complement(3846593..3847420) /Source="Nicolas_S_feature" /locus_tag="new_4185682_4186509_c" /HighExp="T0.30H, Lbstat, H2O2, LPhT, T1.0H, dia15, Diami, T1.30H, dia5, M9-stat" /AntisenseName="yyaQ" /AntisenseCor="0.51412050904654805" /AntisenseRegPval="-18.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1570" promotor_-35 3846641..3846648 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3846662 /Source="Nicolas_upshifts" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3846663..3846682 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3846728..3847002 /Source="Nicolas_S_feature" /locus_tag="new_4185817_4186091" /HighExp="LBGstat, G135, BC, G180, Sw, M9-stat, Diami, T0.30H, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13713" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1571" upshifts 3846728 /Source="Nicolas_upshifts" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3846731..3846736 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3846749..3846768 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3847003..3847359 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391955.1" /db_xref="EnsemblGenomes-Gn:BSU40750" /db_xref="EnsemblGenomes-Tr:CAB16112" /db_xref="InterPro:IPR007351" /db_xref="SubtiList:BG10034" /db_xref="UniProtKB/Swiss-Prot:P37507" /translation="MLTREDIFKHVKEKYGTSPDYPWEKYPNYASLRHTSNKKWYGLI MNVLPEKLGLDGHGEIDILNLKCPPEISDRLRNGENILPGYHMDKEHWISIVLERTDP EGEIYNLIEQSFHLTK*" /label="yyaQ CDS" gene 3847003..3847359 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /label="yyaQ gene" S_feature 3847360..3847518 /Source="Nicolas_S_feature" /locus_tag="new_4186449_4186607" /HighExp="Sw, BC, G135, H2O2, LBGstat, G180, LPhT, T0.30H, Diami, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1572" promotor_-10 complement(3847402..3847421) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3847420) /Source="Nicolas_upshifts" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3847436..3847443) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3847519..3848085 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391956.1" /db_xref="EnsemblGenomes-Gn:BSU40760" /db_xref="EnsemblGenomes-Tr:CAB16113" /db_xref="GOA:P37508" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="PDB:2GD9" /db_xref="SubtiList:BG10035" /db_xref="UniProtKB/Swiss-Prot:P37508" /translation="MTNNLKQRRIILDLAVTLDGFIEGKNGEVDWCIMDPDMGFTDFL NQIDTILYGRKSFDLWGQYIPKNEDPDTEKELWKLVHSKKKYVFSRTQNEIDNQAIFI NDNILEEVNKLKKNPGKDIWLYGGASLITTFINLGLVDEFRLSIHPVVLGEGKPLFID VKQRINLKMVNTRTFSSGVVQIVYHWNG*" /label="yyaP CDS" gene 3847519..3848085 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /label="yyaP gene" CDS complement(3848592..3849968) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7961647, 14636065, 15849754, 16850406, 17015648, 25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7961647, 14636065, 15849754, 16850406, 17015648, 25954268; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multifunctional tetracycline-metal/H+ antiporterand Na+(K+)/H+ antiporter" /protein_id="NP_391957.1" /db_xref="EnsemblGenomes-Gn:BSU40770" /db_xref="EnsemblGenomes-Tr:CAB16114" /db_xref="GOA:P23054" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10036" /db_xref="UniProtKB/Swiss-Prot:P23054" /translation="MNTSYSQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEF NKLPASANWVNTAFMLTFSIGTALYGKLSDQLGIKNLLLFGIMVNGLGSIIGFVGHSF FPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGG MVAHYIHWSYLLLIPTATIITVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFFMLFT TSYRFSFLIISILAFFIFVQHIRKAQDPFVDPELGKNVFFVIGTLCGGLIFGTVAGFV SMVPYMMKDVHHLSTAAIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLS SGFLIAAFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVSSSLKEKEAGAGMSLLNFT SFLSEGTGIAIVGGLLSIGFLDHRLLPIDVDHSTYLYSNMLILFAGIIVICWLVILNV YKRSRRHG*" /label="tetB CDS" gene complement(3848592..3849968) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /label="tetB gene" CDS complement(3850002..3850064) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14636065, 17015648" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636065, 17015648; Product type t: transporter" /codon_start=1 /transl_table=11 /product="tetracycline resistance leader peptide" /protein_id="NP_391958.1" /db_xref="EnsemblGenomes-Gn:BSU40780" /db_xref="EnsemblGenomes-Tr:CAB16115" /db_xref="GOA:P23053" /db_xref="InterPro:IPR012618" /db_xref="SubtiList:BG11051" /db_xref="UniProtKB/Swiss-Prot:P23053" /translation="MKCNKMNRVQLKEGSVSMTL*" /label="tetL CDS" gene complement(3850002..3850064) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /label="tetL gene" promotor_-10 complement(3850085..3850104) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3850104) /Source="Nicolas_upshifts" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3850117..3850124) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3850252..3850258 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3850274..3850293 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3850280 /Source="Nicolas_upshifts" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="upshifts" CDS 3850317..3850556 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391959.1" /db_xref="EnsemblGenomes-Gn:BSU40790" /db_xref="EnsemblGenomes-Tr:CAB16116" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10037" /db_xref="UniProtKB/Swiss-Prot:P37509" /translation="MPNKSKPNRLIAEKSPYLLQHAHNPVDWFPWGEEAFAKAKRENK PVLVSIGYSTTCHWWPGIIKSCGTPLKDNRSHFKR*" /label="yyaO CDS" gene 3850317..3850556 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /label="yyaO gene" downshifts 3850565 /Source="Nicolas_upshifts" /id="D2115" /incds=0 /nref=7 /ntot=103 /MaxReadThrough="1.03879" /MaxDrop="3.89186" /score="10.758481" /energy="-8.2" /TU="NA" /idTUdmin="U3217" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 3850649..3850656 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3850672..3850691 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3850688 /Source="Nicolas_upshifts" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="upshifts" CDS 3850707..3851123 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948146, 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MerR family)" /protein_id="NP_391960.1" /db_xref="EnsemblGenomes-Gn:BSU40800" /db_xref="EnsemblGenomes-Tr:CAB16117" /db_xref="GOA:P37510" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG10038" /db_xref="UniProtKB/Swiss-Prot:P37510" /translation="MLLYSISKAAEKTSISSYTLRYYEKIGLLPPPKRKNSGRRFYTE TDIQFMLFLKSLKETGMSLEDINEFVKDGCILEKINSDVKSAQLSPSINKRIEILTKH LEKMEIKKRELEEVISTTKGKLDTYYSILKEEVENK*" /label="yyaN CDS" gene 3850707..3851123 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /label="yyaN gene" CDS 3851120..3852037 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391961.1" /db_xref="EnsemblGenomes-Gn:BSU40810" /db_xref="EnsemblGenomes-Tr:CAB16118" /db_xref="GOA:P37511" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10039" /db_xref="UniProtKB/Swiss-Prot:P37511" /translation="MKHLNIYIMLLGFSIFTGATFNLAKYTVGYFSPSSSAAWRFGLA AAVMLIILIFTEGIKKSQLRKNAVSYIVLGIIGIFGFNALFFVGLKYTSPVNGALIMG LNPLLTAILARIILKDNMTKKQVLGIFFAFIGVLLVITQGSIETIKTLSISGGDLIIF TGNVCWALYGVLGRRFVKDGTPLSTTTYTMVIGAVSLIVVSLFTSKPVSLSNIPIGVW GAIAFMAFFTSVLGYLWWNQGIKEIGASKTSLFFNLVPVVTMIISFAVGTPIKVFQVI GAVLVILGVLTASGVIRIPKYNTKEQSAI*" /label="yyaM CDS" gene 3851120..3852037 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /label="yyaM gene" misc_feature 3852064..3852083 /Source="Nicolas_upshift_promotors" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3852074 /Source="Nicolas_upshifts" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3852078..3852097) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3852084) /Source="Nicolas_upshifts" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3852109..3854178 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391962.1" /db_xref="EnsemblGenomes-Gn:BSU40820" /db_xref="EnsemblGenomes-Tr:CAB16119" /db_xref="GOA:P37512" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR024705" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10040" /db_xref="UniProtKB/Swiss-Prot:P37512" /translation="MPNKSKPNRLINEKSPYLLQHAHNPVDWFPWGEEAFEKAKRENK PVLVSIGYSTCHWCHVMAHESFEDEEIARLLNERFVAIKVDREERPDVDSVYMRICQL MTGQGGWPLNVFITPDQKPFYAGTYFPKTSKFNRPGFVDVLEHLSETFANDREHVEDI AENAAKHLQTKTAAKTGEGLSESAIHRTFQQLASGFDTIYGGFGQAPKFPMPHMLMYL LRYDHNTGQENALYNVTKTLDSMANGGIYDHIGYGFARYSTDDEWLVPHFEKMLYDNA LLLTAYTEAYQVTQNSRYKEICEQIITFIQREMTHEDGSFFSALDADTEGEEGKYYVW SKEEILKTLGDDLGTLYCQVYDITEEGNFEGKNIPNLIHTKREQIKEDAGLTEKELSL KLEDARQQLLKTREERTYPHVDDKVLTSWNALMIAGLAKAAKVYQEPKYLSLAKDAIT FIENKLIIDGRVMVRYRDGEVKNKGFIDDYAFLLWAYLDLYEASFDLSYLQKAKKLTD DMISLFWDEEHGGFYFTGHDAEALIVREKEVYDGAVPSGNSVAAVQLLRLGQVTGDLS LIEKAETMFSVFKPDIEAYPSGHAFFMQSVLRHLMPKKEIVIFGSADDPARKQIIAEL QKAFKPNDSILVAEQPEQCKDIAPFAADYRIIDGKTTVYICENFACQQPTTNIEEAIH TLISSRD*" /label="yyaL CDS" gene 3852109..3854178 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /label="yyaL gene" promotor_-35 complement(3852111..3852118) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3854142 /Source="Nicolas_upshifts" /id="D2116" /incds=0 /nref=221 /ntot=260 /MaxReadThrough="1.24617" /MaxDrop="5.71843" /score="11.6894527" /energy="-16.6" /TU="NA" /idTUdmin="U3219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3854175..3855074) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11343912, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protease" /protein_id="NP_391963.1" /db_xref="EnsemblGenomes-Gn:BSU40830" /db_xref="EnsemblGenomes-Tr:CAB16120" /db_xref="GOA:P37513" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG10041" /db_xref="UniProtKB/Swiss-Prot:P37513" /translation="MNSFIRPIEGNNTLWRYFFAFLVMVGLYVLGNIAYLFAILFTVI VNPNITFDLDEAVLSDPLVDLYLSHVIYLFAIPGVWLAVRFILKRPFRTVITPNSKMN WRRISFGFIAYFLLMIAVQLIDFVIHPDSYSMQEFNASRFIWLLAAALILVPIQTSAE ELFFRGFLLQAFGRLTKNPLFLTLIVGGLFGVLHFANPEMNNGAVWAGIEYLTFGFVW TYYTIKTGSIEISLGAHAANNMFLCMFITEKNSVYGGIPSLFTVTRGNPMWEAFFTIA VNLVFAGIALWYHKKSKSKQQGS*" /label="yyaK CDS" gene complement(3854175..3855074) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /label="yyaK gene" downshifts complement(3854218) /Source="Nicolas_upshifts" /id="D2117" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="2.6155" /MaxDrop="3.91098" /score="23.2445146" /energy="-14.7" /TU="NA" /idTUdmin="U3221" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3855103..3855122) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3855119) /Source="Nicolas_upshifts" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3855121..3856352) /Source="Nicolas_S_feature" /locus_tag="new_4194210_4195441_c" /HighExp="S6, S8, S7, S5, B36, BT, S4, B60, S3, Diami" /AntisenseName="yyaJ" /AntisenseCor="-0.24400480530035801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1573" promotor_-35 complement(3855137..3855144) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3855215..3855222 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3855236..3855255 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3855242 /Source="Nicolas_upshifts" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3855300..3856655 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 9529885, 19087206, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391964.2" /db_xref="EnsemblGenomes-Gn:BSU40840" /db_xref="EnsemblGenomes-Tr:CAB16121" /db_xref="GOA:P37514" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10042" /db_xref="UniProtKB/Swiss-Prot:P37514" /translation="MNTIFKQKNTHPFSNAANRLDRLPISRVHFQVLTALGIVYFFDL ADLFTLSNVAPALIEHWGIPLSTIANVTAASFLGMFLGASLGGRLSDRIGRKKALNLF VFVFSIASLCNAAAWDIPSLMTFRFLTGFGVAAAMVITNSYLAEFFPSSVRGKYISFC AMIGLIGVPITNIVSAFVIPLGSWGWRLVFVWGAVGLIYFFFIHRLEESPRWHENRGE YAKADAILTRIEEQVEKEKGPLPAASQPKVSETVKQNAGYAGLLKGRNLKITIVLSAV WIFETFGFYGFASWVPSLLKSNGVTMENTLWYNVLHSVGAPLGALLGSMISERFQRKW ILAASAFLTAIAGLLYGMTFIPIMIIVFGFIVNITERVFTSNLYAYTSEPYPTEYRSS GSGLAYGLGRFSNIFGSLLVGFIAVQLGYISVFLFIGGCWLACSLLLIFFGPNTNAKQ I*" /label="yyaJ CDS" gene 3855300..3856655 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /label="yyaJ gene" promotor_-10 complement(3856338..3856357) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3856362) /Source="Nicolas_upshifts" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3856371..3856380) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3856689..3857243) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" /label="maa CDS" gene complement(3856689..3857243) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /label="maa gene" CDS complement(3857261..3857641) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" /label="yyaH CDS" gene complement(3857261..3857641) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /label="yyaH gene" CDS complement(3857697..3858632) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" /label="ccpB CDS" gene complement(3857697..3858632) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /label="ccpB gene" promotor_-35 3858622..3858631 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3858645..3858664 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3858652 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3858676..3858695) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3858690) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3858691..3859449) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" /label="exoA CDS" gene complement(3858691..3859449) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /label="exoA gene" promotor_-35 complement(3858708..3858715) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3858982..3859485 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3859444 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS complement(3859514..3859753) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" /label="rpsR CDS" gene complement(3859514..3859753) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /label="rpsR gene" downshifts complement(3859520) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3859588) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" /label="downshifts" CDS complement(3859797..3860315) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" /label="ssbA CDS" gene complement(3859797..3860315) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /label="ssbA gene" CDS complement(3860356..3860643) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" /label="rpsF CDS" gene complement(3860356..3860643) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /label="rpsF gene" S_feature complement(3860644..3860710) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3860709..3860728) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3860710) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3860742..3860747) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3860754..3861854) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" /label="engD CDS" gene complement(3860754..3861854) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /label="engD gene" promotor_-10 complement(3861902..3861921) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3861917) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="upshifts" promotor_-35 complement(3861936..3861943) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3861981..3863984) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" /label="yyaE CDS" gene complement(3861981..3863984) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /label="yyaE gene" CDS complement(3864035..3864241) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" /label="yyzM CDS" gene complement(3864035..3864241) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /label="yyzM gene" promotor_-10 complement(3864203..3864222) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3864228) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3864237..3864243) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3864267..3864286) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3864278) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="upshifts" promotor_-35 complement(3864303..3864307) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3864335..3865351) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" /label="yyaD CDS" gene complement(3864335..3865351) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /label="yyaD gene" promotor_-10 complement(3865384..3865402) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3865396) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3865418..3865423) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3865527) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" /label="downshifts" promotor_-35 3865711..3865716 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3865729..3865810 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3865729 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3865732..3865750 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3865811..3866428 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" /label="sprC CDS" gene 3865811..3866428 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /label="sprC gene" promotor_-35 3866399..3866407 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3866418 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 3866421..3866439 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3866440 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3866467..3867315) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" /label="parB CDS" gene complement(3866467..3867315) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /label="parB gene" downshifts complement(3866487) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" /label="downshifts" CDS complement(3867308..3868069) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" /label="parA CDS" gene complement(3867308..3868069) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /label="parA gene" misc_feature complement(3868103..3868122) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3868121) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3868213) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="upshifts" promotor_-10 complement(3868216..3868224) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3868238..3868246) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3868250..3868258 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3868266 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3868270..3868288 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3868317..3868757 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" /label="yyaB CDS" gene 3868317..3868757 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /label="yyaB gene" downshifts 3868706 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3868808..3869659) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" /label="nocA CDS" gene complement(3868808..3869659) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /label="nocA gene" downshifts complement(3868827) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(3869660..3869780) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3869781..3870500) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" /label="rsmG CDS" gene complement(3869781..3870500) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /label="rsmG gene" CDS complement(3870514..3872400) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" /label="trmF CDS" gene complement(3870514..3872400) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /label="trmF gene" CDS complement(3872421..3873800) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" /label="mnmE CDS" gene complement(3872421..3873800) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /label="mnmE gene" S_feature complement(3873801..3873931) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3873923..3873942) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3873931) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3873958..3873962) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3873986..3874005) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3873996) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="upshifts" promotor_-35 complement(3874019..3874026) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3874086..3874092 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3874097..3876382 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3874097 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3874107..3874126 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3874111..3874737) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" /label="jag CDS" gene complement(3874111..3874737) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /label="jag gene" downshifts complement(3874128) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3874734..3875519) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" /label="oxaAA CDS" gene complement(3874734..3875519) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /label="oxaAA gene" promotor_-10 complement(3875564..3875583) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3875576) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3875578..3875663) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3875595..3875601) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3875664..3876014) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" /label="rnpA CDS" gene complement(3875664..3876014) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /label="rnpA gene" S_feature complement(3876015..3876165) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3876166..3876300) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" /label="rpmH CDS" gene complement(3876166..3876300) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /label="rpmH gene" promotor_no_box 3876324..3876424 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3876336..3876355) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3876346) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3876348..3876416) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3876371..3876378) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3876384..>3876517 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3876384 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3876402..3876421) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3876416) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3876437..3876441) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3876518..3876665 /locus_tag="new_1_148" /created_by="stephanmichalik" /label="S1" S_feature complement(3876541..3876814) /locus_tag="new_24_297_c" /created_by="stephanmichalik" /label="S2" S_feature 3876667..3876926 /locus_tag="new_150_409" /created_by="stephanmichalik" /label="S3" ORIGIN 1 atggaaaata tattagacct gtggaaccaa gcccttgctc aaatcgaaaa aaagttgagc 61 aaaccgagtt ttgagacttg gatgaagtca accaaagccc actcactgca aggcgataca 121 ttaacaatca cggctcccaa tgaatttgcc agagactggc tggagtccag atacttgcat 181 ctgattgcag atactatata tgaattaacc ggggaagaat tgagcattaa gtttgtcatt 241 cctcaaaatc aagatgttga ggactttatg ccgaaaccgc aagtcaaaaa agcggtcaaa 301 gaagatacat ctgattttcc tcaaaatatg ctcaatccaa aatatacttt tgatactttt 361 gtcatcggat ctggaaaccg atttgcacat gctgcttccc tcgcagtagc ggaagcgccc 421 gcgaaagctt acaacccttt atttatctat gggggcgtcg gcttagggaa aacacactta 481 atgcatgcga tcggccatta tgtaatagat cataatcctt ctgccaaagt ggtttatctg 541 tcttctgaga aatttacaaa cgaattcatc aactctatcc gagataataa agccgtcgac 601 ttccgcaatc gctatcgaaa tgttgatgtg cttttgatag atgatattca atttttagcg 661 gggaaagaac aaacccagga agaatttttc catacattta acacattaca cgaagaaagc 721 aaacaaatcg tcatttcaag tgaccggccg ccaaaggaaa ttccgacact tgaagacaga 781 ttgcgctcac gttttgaatg gggacttatt acagatatca caccgcctga tctagaaacg 841 agaattgcaa ttttaagaaa aaaggccaaa gcagagggcc tcgatattcc gaacgaggtt 901 atgctttaca tcgcgaatca aatcgacagc aatattcggg aactcgaagg agcattaatc 961 agagttgtcg cttattcatc tttaattaat aaagatatta atgctgatct ggccgctgag 1021 gcgttgaaag atattattcc ttcctcaaaa ccgaaagtca ttacgataaa agaaattcag 1081 agggtagtag gccagcaatt taatattaaa ctcgaggatt tcaaagcaaa aaaacggaca 1141 aagtcagtag cttttccgcg tcaaatcgcc atgtacttat caagggaaat gactgattcc 1201 tctcttccta aaatcggtga agagtttgga ggacgtgatc atacgaccgt tattcatgcg 1261 catgaaaaaa tttcaaaact gctggcagat gatgaacagc ttcagcagca tgtaaaagaa 1321 attaaagaac agcttaaata gcaggaccgg ggatcaatcg gggaaagtgt gaataacttt 1381 tcggaagtca tacacagtct gtccacatgt ggataggctg tgtttcctgt ctttttcaca 1441 acttatccac aaatccacag gccctactat tacttctact attttttata aatatatata 1501 ttaatacatt atccgttagg aggataaaaa tgaaattcac gattcaaaaa gatcgtcttg 1561 ttgaaagtgt ccaagatgta ttaaaagcag tttcatccag aaccacgatt cccattctga 1621 ctggtattaa aattgttgca tcagatgatg gagtatcctt tacagggagt gactcagata 1681 tttctattga atccttcatt ccaaaagaag aaggagataa agaaatcgtc actattgaac 1741 agcccggaag catcgtttta caggctcgct tttttagtga aattgtaaaa aaattgccga 1801 tggcaactgt agaaattgaa gtccaaaatc agtatttgac gattatccgt tctggtaaag 1861 ctgaatttaa tctaaacgga ctggatgctg atgaatatcc gcacttgccg cagattgaag 1921 agcatcatgc gattcagatc ccaactgatt tgttaaaaaa tctaatcaga caaacagtat 1981 ttgcagtgtc cacctcagaa acacgcccta tcttgacagg tgtaaactgg aaagtggagc 2041 aaagtgaatt attatgcact gcaacggata gccaccgtct tgcattaaga aaggcgaaac 2101 ttgatattcc agaagacaga tcttataacg tcgtgattcc gggaaaaagt ttaactgaac 2161 tcagcaagat tttagatgac aaccaggaac ttgtagatat cgtcatcaca gaaacccaag 2221 ttctgtttaa agcgaaaaac gtcttgttct tctcacggct tctggacggg aattatccag 2281 acacaaccag cctgattccg caagacagca aaacagaaat cattgtgaac acaaaagaat 2341 tccttcaggc cattgatcgt gcatctcttt tagctagaga gggacgcaac aacgttgtaa 2401 aactgtccgc aaaaccggct gaatccattg aaatttcttc caattcgcca gaaatcggta 2461 aagttgtgga agcaattgtt gcggatcaaa ttgaaggtga ggaattaaat atctctttta 2521 gtccaaaata tatgctggat gcactaaagg tgcttgaagg agcagaaata cgcgtaagct 2581 ttacaggcgc aatgagacct ttcttaattc gcacgccgaa tgatgaaacg attgtacagc 2641 ttatccttcc tgtcagaacc tattaatccg atacactgct gccgacccgt cggcagcttt 2701 tctattcggt atctgctccg acaagttttc cctttcccta attcgttttt ttttagtaca 2761 attagatatt agtgatattt gaaagaggtc gatataatgg caaatccgat ttcaattgat 2821 acagagatga ttacactcgg acaattctta aaattagccg atgtgattca gtctggcggt 2881 atggcgaagt ggtttttaag cgagcatgaa gtgcttgtga acgatgagcc ggacaaccgc 2941 cggggcagaa agctgtatgt tggagatgtg gtagagattg aaggatttgg ttcatttcaa 3001 gtcgtcaatt aaagcgggtg acactgattg tatatccaga acttagaact gacatcttac 3061 cgcaactacg accatgctga acttcaattt gaaaataaag taaatgtgat catcggagaa 3121 aacgcccagg ggaagacaaa cctcatggag gcgatctatg tcttgtccat ggcgaaatcg 3181 caccggacat caaatgacaa agaacttata cggtgggaca aagactatgc taaaatagag 3241 ggaagagtga tgaagcaaaa cggggcgatc ccgatgcagc tcgtcatctc caaaaagggt 3301 aaaaagggca aggtcaatca tattgaacag caaaagctca gccagtatgt cggggccctc 3361 aacaccatta tgttcgcgcc ggaagattta aatcttgtaa agggaagccc tcaagtgaga 3421 aggcggtttc ttgacatgga aatcggacag gtttctcccg tctaccttca tgatctttct 3481 ctttaccaga aaatcctttc ccagcggaat cattttttga aacagctgca aacaagaaaa 3541 caaactgacc ggacgatgct cgatgttctg accgatcagc ttgtagaagt tgcagcaaaa 3601 gtcgtcgtaa aacgcctgca gtttacagca cagctcgaga aatgggcgca gcccatccat 3661 gcaggcatct caagagggct tgaagaactg accctgaaat accatacagc tcttgatgta 3721 tcagatcccc tagatttgtc gaaaatagga gatagctatc aagaagcgtt ttctaaatta 3781 agagaaaaag aaattgagcg tggtgtgacg ctgtcagggc ctcatcgcga tgatgttctt 3841 ttctatgtga acggacgcga tgtgcagacg tatggttctc aaggacagca gcgaacgacg 3901 gcgttgtccc ttaagctggc ggagattgac ctgatccatg aagaaatcgg agaatatccc 3961 attttactat tggatgatgt actgagtgaa ctggatgatt atcgccagtc acacttgctt 4021 catacgatcc aaggccgtgt acaaacgttt gtcacaacga caagcgttga tggcattgat 4081 cacgaaacct tacgtcaagc aggaatgttc cgtgtgcaaa atggtgcgtt agtgaagtga 4141 agaaatgagg tgagcaattg tatattcatt taggtgatga ctttgtggtt tcaacacgag 4201 atattgtcgg catttttgac tttaaagcca acatgtcgcc tattgttgaa gaatttctga 4261 aaaaacagaa acacaaggtg gtgccttccg taaacggcac gcccaaatct atcgtagtca 4321 cggttcagaa tatatattac tctcccttat cttccagcac attaaaaaaa cgtgcgcaat 4381 ttatgtttga aatagattct tagaaatttt ttatcacgaa tatatcgttt agaaaagtgt 4441 aggtgaatga cgtggctatg gaacagcagc aaaacagtta tgatgaaaat cagatacagg 4501 tactagaagg attggaagct gttcgtaaaa gaccggggat gtatatcggt tcgacaaaca 4561 gcaaaggcct tcaccacttg gtatgggaaa ttgtcgacaa tagtattgac gaagccctcg 4621 ccggttattg tacggatatc aatatccaaa tcgaaaaaga caacagtatc acggttgtag 4681 ataatggccg cggtattcca gtcggtattc atgaaaaaat gggccgtcct gcggtagaag 4741 tcattatgac ggtgcttcat gccggaggaa aatttgacgg aagcggctat aaagtatccg 4801 gaggattaca cggtgtaggt gcgtcggtcg taaacgcact atcaacagag cttgatgtga 4861 cggttcaccg tgacggtaaa attcaccgcc aaacctataa acgcggagtt ccggttacag 4921 accttgaaat cattggcgaa acggatcata caggaacgac gacacatttt gtcccggacc 4981 ctgaaatttt ctcagaaaca accgagtatg attacgatct gcttgccaac cgcgtgcgtg 5041 aattagcctt tttaacaaag ggcgtaaaca tcacgattga agataaacgt gaaggacaag 5101 agcgcaaaaa tgaataccat tacgaaggcg gaattaaaag ttatgtagag tatttaaacc 5161 gctctaaaga ggttgtccat gaagagccga tttacattga aggcgaaaag gacggcatta 5221 cggttgaagt ggctttgcaa tacaatgaca gctacacaag caacatttac tcgtttacaa 5281 acaacattaa cacgtacgaa ggcggtaccc atgaagctgg cttcaaaacg ggcctgactc 5341 gtgttatcaa cgattacgcc agaaaaaaag ggcttattaa agaaaatgat ccaaacctaa 5401 gcggagatga cgtaagggaa gggctgacag cgattatttc aatcaaacac cctgatccgc 5461 agtttgaggg ccaaacaaaa acaaagctgg gcaactcaga agcacggacg atcaccgata 5521 cgttattttc tacggcgatg gaaacattta tgctggaaaa tccagatgca gccaaaaaaa 5581 ttgtcgataa aggtttaatg gcggcaagag caagaatggc tgcgaaaaaa gcgcgtgaac 5641 taacacgccg taagagtgct ttggaaattt caaacctgcc cggtaagtta gcggactgct 5701 cttcaaaaga tccgagcatc tccgagttat atatcgtaga gggtgactct gccggaggat 5761 ctgctaaaca aggacgcgac agacatttcc aagccatttt gccgcttaga ggtaaaatcc 5821 taaacgttga aaaggccaga ctggataaaa tcctttctaa caacgaagtt cgctctatga 5881 tcacagcgct cggcacaggt atcggagaag acttcaacct tgagaaagcc cgttaccaca 5941 aagttgtcat tatgacagat gccgatgttg acggcgcgca catcagaaca ctgctgttaa 6001 cgttctttta cagatatatg cgccaaatta tcgaaaatgg ctacgtgtac attgcgcagc 6061 cgccgctcta caaggttcaa caggggaaac gcgttgaata tgcatacaat gacaaggagc 6121 ttgaagagct gttaaaaact cttcctcaaa cgcctaagcc tggactgcag cgttacaaag 6181 gtcttggtga aatgaatgcc acccagctat gggagacaac catggatcct agctccagaa 6241 cacttcttca ggtaactctt gaagatgcaa tggatgcgga tgagactttt gaaatgctta 6301 tgggcgacaa ggtagaaccg cgccgaaact tcatagaagc gaatgcgaga tacgttaaaa 6361 atcttgacat ctaatcataa aaagccttat ttccaataag aaataaggct tttttctgaa 6421 caagatcaga tgcagcgatg cctgcaatac ctatatattc tagcaattta atgtgtataa 6481 tcataagttt attgatataa tggagaatag tgaaatcgta ttgaaggtca taatggacaa 6541 tctactccca catatttcat gtgatacttc agggaggttt tttaatgagt gaacaaaaca 6601 caccacaagt tcgtgaaata aatatcagtc aggaaatgcg tacgtccttc ttggattatg 6661 caatgagcgt tatcgtgtcc cgtgctcttc cggatgttcg tgacggttta aaaccggttc 6721 atagacggat tttgtatgca atgaatgatt taggcatgac aagtgacaag ccttataaaa 6781 aatccgcgcg tatcgttgga gaagttatcg ggaaatacca cccgcacggt gattcagcgg 6841 tatatgaatc catggtcaga atggctcagg atttcaacta ccgttatatg ctcgttgacg 6901 gtcacggaaa cttcggttct gttgacggag actcagcggc ggccatgcgt tatacagaag 6961 cacgaatgtc taaaatctca atggagattc ttcgcgacat cacaaaagac acaatcgatt 7021 accaggataa ctatgacggg tcagaaagag aacctgtcgt tatgccttca aggttcccga 7081 atctgctcgt gaacggtgct gccggcattg cggtaggtat ggcaacaaac attcctccgc 7141 accagctggg agaaatcatt gacggtgtac ttgctgttag tgagaatccg gacattacaa 7201 ttccagagct tatggaagtc attccagggc ctgatttccc gaccgcgggt caaatcttgg 7261 gacgcagcgg tatccggaaa gcatacgaat caggccgagg ctctatcacg atccgggcaa 7321 aagctgagat cgaacaaaca tcttcgggta aagaaagaat tatcgttaca gagttacctt 7381 accaagtaaa taaggcgaaa ttaattgaga aaattgctga tctcgtaagg gacaaaaaga 7441 tagagggtat cacagatctg cgtgatgagt cagatcgtac aggtatgaga attgtcattg 7501 aaatcagacg cgatgccaat gcgaatgtta tcttaaacaa tctgtacaaa caaactgctc 7561 tacaaacatc ttttggcatc aacctgcttg cgcttgttga tggccagccg aaagttttaa 7621 ctcttaagca atgcctggag cattaccttg accatcaaaa agttgtcatt agacgccgta 7681 ctgcttatga attgcgtaaa gcagaagcga gagctcatat cttggaagga ttgagagttg 7741 cactggatca tctcgatgca gttatctccc ttatccgtaa ttctcaaacg gctgaaattg 7801 cgagaacagg tttaattgaa caattctcac tgacagagaa gcaagcacaa gcgatccttg 7861 acatgaggct ccagcgttta acgggactgg aacgtgaaaa gatcgaagaa gaataccagt 7921 ctcttgttaa attaattgca gagctaaaag acatcttggc aaatgaatat aaagtgcttg 7981 agatcattcg tgaagaactc acggaaatca aagagcgttt taacgatgaa agacgtactg 8041 agatcgtcac ttctggactg gagacaattg aagatgaaga tctcatcgag agagaaaata 8101 tcgtagttac tctgacgcac aacggatacg tcaaacgtct tcctgcatca acttaccgca 8161 gtcaaaaacg gggcggaaaa ggtgtacaag gtatgggaac aaacgaagat gatttcgttg 8221 aacatttgat ctctacgtca actcatgaca cgattctctt cttctcgaac aaggggaaag 8281 tgtatcgtgc aaaagggtat gaaatccctg aatacggcag aacggcaaaa ggaatcccga 8341 ttattaacct gctggaggta gaaaagggtg agtggatcaa cgcgattatt ccagtcacgg 8401 aattcaatgc ggagctttac ctcttcttca ctacaaagca tggggtttca aaacgaacat 8461 cgctatctca attcgctaat atccgcaaca atggtctaat tgctctgagt cttcgtgaag 8521 atgatgaact gatgggtgta cgtctgactg acggcacaaa acaaatcatc attggaacga 8581 aaaacggttt actgattcgt ttccctgaaa cagatgtccg agagatggga agaactgcgg 8641 cgggcgtaaa aggcatcacc ctgacggatg acgacgttgt tgtcggcatg gagattttag 8701 aggaagaatc acacgtcctt atcgtaactg aaaaagggta cggaaaacga actcctgctg 8761 aagagtacag aacccaaagc cggggcggaa aaggactcaa aacagcgaaa atcaccgaga 8821 acaacggcca actagtagca gtgaaagcta ctaaaggtga agaggatcta atgattatta 8881 cagctagcgg cgtactcatc agaatggaca tcaatgatat ctccatcacc ggacgtgtca 8941 ctcaaggtgt gcgtctcatc agaatggcag aagaagagca tgttgctaca gtagctttag 9001 ttgagaaaaa cgaagaagat gagaatgaag aagaacaaga agaagtgtga aaaaaagcgc 9061 agctgaaata gctgcgcttt tttgtgtcat aaccctttac agtcataaaa attatggtat 9121 aatcatttct gttgtctttt taaagacaca agcatgacca ttatgactag taaaaacttt 9181 ttcaaaaaag tattgaccta gttaactaaa aatgttacta ttaagtagtc gctttgagag 9241 aagcacacaa agttctttga aaactaaaca agacaaaacg tacctgttaa ttcattttta 9301 taaatcgcac agcgatgtgc gtagtcagtc aaactagggc ctgcacgacg caggtcacac 9361 aggtgtcgcc gcaggatgcg gtgaacttaa cctgtgatcc atttatcgga gagtttgatc 9421 ctggctcagg acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg 9481 agcttgctcc ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa 9541 gactgggata actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt 9601 caaacataaa aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt 9661 tggtgaggta acggctcacc aaggcgacga tgcgtagccg acctgagagg gtgatcggcc 9721 acactgggac tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc 9781 aatggacgaa agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa 9841 gctctgttgt tagggaagaa caagtgccgt tcgaataggg cggtaccttg acggtaccta 9901 accagaaagc cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt 9961 tgtccggaat tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc 10021 ccccggctca accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag 10081 tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg 10141 cgactctctg gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag 10201 ataccctggt agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct 10261 tagtgctgca gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac 10321 tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac 10381 gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt 10441 cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt 10501 taagtcccgc aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta 10561 aggtgactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct 10621 tatgacctgg gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg 10681 ttaagccaat cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg 10741 aagctggaat cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt 10801 gtacacaccg cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt 10861 ttaggagcca gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc 10921 gtatcggaag gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc 10981 ttgggtctta taaacagaac gttccctgtc ttgtttagtt ttgaaggaac tttgttcctt 11041 gaataagtta agatgggcct gtagctcagc tggttagagc gcacgcctga taagcgtgag 11101 gtcggtggtt cgagtccact caggcccacc atcttatata acggggcctt agctcagctg 11161 ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg ctccaccaac 11221 gtgttctttg aaaactagat aacagtagac atcacattca attagtaaca caagatatca 11281 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 11341 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 11401 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 11461 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 11521 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga 11581 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg 11641 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 11701 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 11761 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 11821 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 11881 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatctc 11941 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 12001 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 12061 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 12121 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 12181 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 12241 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 12301 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 12361 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 12421 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 12481 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 12541 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 12601 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 12661 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 12721 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 12781 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 12841 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 12901 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 12961 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 13021 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 13081 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 13141 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 13201 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 13261 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 13321 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 13381 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 13441 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 13501 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 13561 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 13621 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 13681 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 13741 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 13801 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 13861 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 13921 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 13981 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 14041 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 14101 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 14161 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact 14221 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaac actctcaatt 14281 tgtttggtgg cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc 14341 tcttcagcgc cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa 14401 gcttaaaccc agctcaatga gctgggtttt ttgtttgtta aaaatgaaga agaaactgtg 14461 aagcgtattt agggaatttc ttttctgata ctaataaaaa ctgctgaatt aacacgtagt 14521 catcacttat atgctgtgtt aataactcat accaccattc tgtttcatac cttgcaatca 14581 tcccaacgtt gtacaaaatc aaataatgaa ttgtcatttc gggaagcctc agaaattgct 14641 ccctttgaga agggatataa tattggttct tttccatgtc aaacaataag ctggtcgatg 14701 tccatggctc cttgtcttgt ggtgaaattt cgaacagcag cccgtgttca tttttttttg 14761 taaaagacca ttgataatga tgggacatgt attcagcaaa ccttgaatca gacattttgt 14821 aattgattac tacttcctcc ggtacaaaaa tttcgttctt atccttctca acttttgtca 14881 taaatcgttc tttctgctga aagtagaaaa tatcgctaag ttctggaatg gccattaata 14941 attttttcat ggtataccgt tcatctacta tatccgattg tccgaataaa tgtttcataa 15001 aatgtacgca taggccattc cgttgtattt tcacttcatc gtcgctaaaa caataatttt 15061 gtttctttcg ttttcttgtt gttacgccat gtgccagtac tgatgtatgg cttggataat 15121 gaggatcacg tgtaattaag catgctttga taagctgtgc cattccataa aataaaagaa 15181 tcggtttgat ttctaaggga gaatatgcgg cttgtttata aaacgattcg gcatgcttta 15241 agaaataaat aaaccgttca ctgtttttaa aagagttttt tttcgcatcg ttaataccgt 15301 ttaagatata aaccttttct agaaatttct gggttgattc aacggagtaa aatagcgcta 15361 agtctttcca ctcatgatat gtcatgtata tttcttaatc ctttccgtta tctaaatatt 15421 tcaactcttt cccgcttcct tgacatgctc ttggctagtt gataatctac atataatatt 15481 ttgccgaaaa gagggggatt tactaatgtg ggaaagtaaa ttttcaaaag aaggcttaac 15541 gttcgacgat gtgctgcttg taccagcaaa gtctgaggta cttccgcgtg atgtggattt 15601 atctgtagaa cttacaaaaa cgttaaagct aaatattcct gtcatcagcg caggtatgga 15661 cactgtaaca gaatcagcaa tggcaattgc aatggcaaga cagggcggct tgggcatcat 15721 tcacaaaaat atgtccattg aacagcaggc tgaacaagtt gataaagtaa agcgttctga 15781 gcgcggcgtt atcacaaatc ccttcttttt aactcctgat caccaagtat ttgatgcgga 15841 gcatttgatg gggaaataca gaatttccgg tgttccgatt gtaaataacg aagaagacca 15901 gaagcttgtt ggaattatta caaaccgtga ccttcgtttt atttctgact actcaatgaa 15961 aatcagcgac gtcatgacga aagaagagct agttactgca tctgtaggaa ctactctgga 16021 tgaagctgaa aagattttgc agaaacataa aattgaaaag cttcctctcg tagatgacca 16081 gaataaatta aaaggtctta tcacaattaa agacattgaa aaagtcattg agttcccgaa 16141 ctcatctaaa gacattcacg gccgcctgat cgttggcgcg gcagttggtg taactggcga 16201 tacaatgact cgcgtcaaaa agcttgttga agccaatgtt gatgtgattg ttatcgatac 16261 agctcacgga cactctcaag gcgttttaaa cacagtcaca aaaatccgtg aaacgtatcc 16321 cgaattaaac attattgctg gaaacgtggc aacagctgaa gcgacaagag cgcttatcga 16381 agctggagca gacgttgtca aagttggaat agggcctggt tcaatttgta ctacacgtgt 16441 tgtagccggc gtgggtgttc cgcaaattac agcaatttat gattgtgcga ctgaagcaag 16501 aaaacacggc aaaacaatca tcgccgacgg tgggattaaa ttctctggcg atatcactaa 16561 agcattggca gccggcggac atgctgttat gctcggaagc ttgcttgcag gcacatcaga 16621 aagccctggt gaaactgaaa tctaccaagg cagaagattt aaggtatacc gcggcatggg 16681 atcagttgct gcaatggaaa aaggaagtaa agaccgttac ttccaagaag aaaacaaaaa 16741 atttgttcct gaaggaattg aaggacgcac accttacaaa gggccagttg aagaaaccgt 16801 ttatcagcta gtcggaggcc ttcgttctgg tatggggtat tgcgggtcca aagatctgcg 16861 tgcgctaaga gaagaagctc agttcattcg catgactggc gcaggacttc gcgaaagcca 16921 tccgcatgac gtacagatta caaaagaatc acctaactat acaatttcat aataaattgt 16981 tacaaattaa aaacatttga cagggtctct gactctgtct atttttttta tactgattat 17041 gataaaattt atactgttgt gcattgaaaa tgtccttaac ggcttaatta tagatgaaga 17101 aaatgaaata cggaggtcgt acgattgaac atcaagaaat gtaaacagct actgatgtca 17161 ttggttgtgt taactctagc tgtcacgtgt ctggctccaa tgtcaaaagc gaaagcagcc 17221 agcgatccaa ttgatatcaa tgcatctgct gctattatga tcgaagcttc ttcaggtaaa 17281 attctttaca gtaaaaatgc agataagaga ctgccaattg cgagtatgac aaaaatgatg 17341 acagagtatc tgttattgga agcaattgat caaggtaaag tgaaatggga ccaaacctat 17401 acgcctgatg actatgtgta tgaaatttcc caagataaca gcttatcaaa cgttcctctt 17461 cggaaagacg ggaaatacac agtaaaagaa ttatatcaag ctacagcaat ttattctgca 17521 aatgctgctg ctattgcgat tgcagaaatc gttgccggtt ctgaaactaa gtttgttgaa 17581 aaaatgaatg caaaagcaaa agaactaggc ttaacagatt acaaatttgt taacgcaaca 17641 ggtcttgaaa acaaagatct tcacgggcat cagcctgagg ggacaagcgt aaatgaagaa 17701 agtgaagttt ctgcaaagga tatggcggtt cttgcggatc acttgattac tgactaccct 17761 gagatactgg agacttccag tatcgccaaa acgaaattca gagaaggcac cgatgatgaa 17821 atggacatgc cgaactggaa ttttatgctg aaggggcttg tcagcgagta taaaaaagcg 17881 actgtagacg gactgaaaac aggttctact gactctgcgg gttcatgctt tacaggaaca 17941 gctgaacgca acggtatgcg tgtcatcact gttgttttaa acgcaaaggg caaccttcat 18001 acaggccgtt tcgatgaaac gaaaaaaatg tttgattatg ctttcgacaa tttctccatg 18061 aaagaaattt atgctgaagg cgatcaagta aaaggccata aaacaatttc agttgataag 18121 ggtaaagaga aagaagtagg cattgtgaca aacaaggcgt tctctcttcc tgtcaaaaat 18181 ggtgaagaaa agaattacaa agcgaaggtc acactgaata aagacaactt aactgctcct 18241 gtgaaaaaag gaaccaaggt tgggaagctg actgcggaat acacaggtga tgaaaaggat 18301 tacggattcc ttaacagcga tctggctggc gtagaccttg ttacaaaaga aaatgtagaa 18361 aaagcaaact ggtttgtttt gacaatgcgc agtatcggcg gattttttgc cggaatttgg 18421 ggaagcattg ttgatacggt aaccggctgg ttttaatcaa ttgaaagagc tctgatggat 18481 gttagggctc tttcgcgtaa tatactgaaa aaacccaatt tttaataaaa aatgattttc 18541 aaagcgctaa aaaccgaata aaatagtata tatgcatatg aattattgga tttctaggat 18601 acaataagga ttagaaatca tataactata ccttgattag ggggaccaag aaatggctca 18661 aacaggtact gaacgtgtaa aacgcggaat ggcagaaatg caaaaaggcg gcgtcatcat 18721 ggacgtcatc aatgcggaac aagcgaaaat cgctgaagaa gctggagctg tcgctgtaat 18781 ggcgctagaa cgtgtgccag cagatattcg cgcggctgga ggagttgccc gtatggctga 18841 ccctacaatc gtggaagaag taatgaatgc agtatctatc ccggtaatgg caaaagcgcg 18901 tatcggacat attgttgaag cgcgtgtgct tgaagctatg ggtgttgact atattgatga 18961 aagtgaagtt ctgacgccgg ctgacgaaga atttcattta aataaaaatg aatacacagt 19021 tccttttgtc tgtggctgcc gtgatcttgg tgaagcaaca cgccgtattg cggaaggtgc 19081 ttctatgctt cgcacaaaag gtgagcctgg aacaggtaat attgttgagg ctgttcgcca 19141 tatgcgtaaa gttaacgctc aagtgcgcaa agtagttgcg atgagtgagg atgagctaat 19201 gacagaagcg aaaaacctag gtgctcctta cgagcttctt cttcaaatta aaaaagacgg 19261 caagcttcct gtcgttaact ttgccgctgg cggcgtagca actccagctg atgctgctct 19321 catgatgcag cttggtgctg acggagtatt tgttggttct ggtattttta aatcagacaa 19381 ccctgctaaa tttgcgaaag caattgtgga agcaacaact cactttactg attacaaatt 19441 aatcgctgag ttgtcaaaag agcttggtac tgcaatgaaa gggattgaaa tctcaaactt 19501 acttccagaa cagcgtatgc aagaacgcgg ctggtaagaa cataggagcg ctgctgacat 19561 gttaacaata ggtgtactag gacttcaagg agcagttaga gagcacatcc atgcgattga 19621 agcatgcggc gcggctggtc ttgtcgtaaa acgtccggag cagctgaacg aagttgacgg 19681 gttgattttg ccgggcggtg agagcacgac gatgcgccgt ttgatcgata cgtatcaatt 19741 catggagccg cttcgtgaat tcgctgctca gggcaaaccg atgtttggaa catgtgccgg 19801 attaattata ttagcaaaag aaattgccgg ttcagataat cctcatttag gtcttctgaa 19861 tgtggttgta gaacgtaatt catttggccg gcaggttgac agctttgaag ctgatttaac 19921 aattaaaggc ttggacgagc cttttactgg ggtattcatc cgtgctccgc atattttaga 19981 agctggtgaa aatgttgaag ttctatcgga gcataatggt cgtattgtag ccgcgaaaca 20041 ggggcaattc cttggctgct cattccatcc ggagctgaca gaagatcacc gagtgacgca 20101 gctgtttgtt gaaatggttg aggaatataa gcaaaaggca cttgtataaa acagttgaaa 20161 gctgtggaaa cttatagtac attataagca caaataaaga tcgaaaagcg ttgataggaa 20221 ctagtaggga gcctctcttt ctaagagagc cgatggttgg tgcgaatcgg tgaaagatgc 20281 tgtctgaatc catccttgag cgaaatgctg aagcgagtag gcatttacgg gataaccgtt 20341 atgtttgaaa gtggaaaacg agtctttgat ttgttttcaa tcagggtggc aacgcgagag 20401 ctctcgtccc tttatgggga tgagggctct ttttattttc gataaatcaa taaaaaaagg 20461 agtgtttcgc atgcttgata cgaaaatgct gagagcaaat tttcaagaaa ttaaagcaaa 20521 gcttgtacac aaaggcgaag acttaactga ttttgataag tttgaggcgc tggatgatag 20581 acgaagagag cttatcggca aggttgaaga gttaaaagga aaacgaaatg aagtttctca 20641 gcaggttgct gtgctgaagc gtgagaaaaa agacgcggat cacattatta aagaaatgcg 20701 tgaagtcggc gaggaaatta aaaagctcga tgaagaatta cggacagtgg aagctgagct 20761 tgatacaatc ctgctctcaa tcccgaatat tccgcatgag tctgtacctg tcggtgaaac 20821 agaagacgac aacgtagaag tgcgtaaatg gggtgaaaag ccttcatttg cttatgagcc 20881 gaagccgcac tgggatattg cggatgagct gggtattctg gattttgaac gtgctgccaa 20941 agtaacagga agccgtttcg tgttctataa aggcttaggt gctcgtctgg agcgtgcgct 21001 ttataacttt atgcttgatc tgcatgtgga tgagtataac tacactgaag tgatcccgcc 21061 atatatggta aaccgcgcaa gcatgacggg aacggggcag cttcctaaat ttgaagagga 21121 tgcatttaaa atcagagaag aagattattt cttaattcca acggcggaag tgccgattac 21181 aaacatgcat cgcgatgaaa tcctttcagg tgacagcctg ccgatcaact atgcggcatt 21241 cagtgcttgc ttccgttctg aagctggttc agcaggacgt gacacacgcg gattaattcg 21301 tcagcaccaa tttaataaag ttgagcttgt aaagtttgtg aagcctgaag attcttatga 21361 agaattagag aaacttacaa accaagcaga acgggttctt cagctgcttg agcttccata 21421 ccgtgtcatg agcatgtgta cgggtgactt aggctttacg gctgcgaaaa aatacgatat 21481 cgaagtttgg attccaagcc aagacacata tcgagaaatc tcttcttgca gcaacttcga 21541 agcgttccag gcgagacgtg cgaatattcg tttcagacgt gaagcgaaag gcaagcctga 21601 gcatgtacac acactgaacg gctcaggact ggcggttgga agaacagttg ctgctatctt 21661 agaaaattat cagcaggaag acggaagcgt tgtgattccg aaagtgcttc gtccttatat 21721 ggggaataga gaagtaatga aaccgtaaat tatggaaagg cgtgcctgac aaggtgcgcc 21781 tttttgctta tgtaaacacg gcattttcat aaaaacaaaa aaagttttta aaaatgcttg 21841 accacacgag aacatacgtg atatagttag tcttgtcgat acggaggaat acccaagtcc 21901 ggctgaaggg atcggtcttg aaaaccgaca ggggtgtcaa agcccgcggg ggttcgaatc 21961 cctcttcctc cgccatattg attttaattc taatgaaaca caagcatata ttggagattg 22021 ttttgtccgt tgcattcggt gcggcggatt ttttatttta aagaaaaagt gaatctcgac 22081 tgagattcac tttttttgat tatcatgaat aactgaagca atttgatcta caatattttc 22141 aatcgagttt tcgtcgttca gaagatcata atcttcaatg cgaagtttta aaacagggca 22201 ggcattaaaa ccgcttatcc agttctcgta gcgtgtatgc atttcttccc aataagaccg 22261 gcttgtctga agctccatct cacggccgcg ttgttcaatc cggtttaaaa tgttctccag 22321 atctccttct aaatagatca acacatctgg atgtgggaaa tacggtgtca ttaccattgc 22381 ttcgaaaagg cttgtgtaag tcttataatc aacctttgac attgtccctt tatcagcatg 22441 catttttgcg aaaattcctg tatcttcata aatcgaacga tcctgtacaa aacctccgcc 22501 ggcttcaaaa attgttttct gttctttgaa gcgttcagct aagaagtaaa tttgaaggtg 22561 aaagctccaa cgttcaaaat catgatagaa cttttccaaa tatggattat gatcgacttc 22621 ctccaacgat gttttaaatc caagccgttt agctaaagtt tttgttaaag tcgattttcc 22681 gacacctact gttcctgcta ctgtaataat tgaattctta gggatatgat gttccttcat 22741 acgataagct cctttacatg ggcggcaatg cgttcaaagt cgctcttatt caaaacgaaa 22801 tcctttgaat caccatctac ggttaacact gtaagttcag ggtctgcttc ctgcagctgc 22861 ttgatggcga cttcataatc tgaaatcagc tgctccaaat agctagtttc aatttttttc 22921 tcaaaggggc gcccgcgttt ttcaatgcgg tgtagcaatg taggcagact ggcctttatg 22981 taaatgatga aattcggctt tggcagatca tccgttagca ggtgatatat ctttttgtat 23041 ttttccagct gatgtggaga caaggttcgt tccgcaaaaa tcacattttt ataaatatga 23101 taatcagcta ttacaggctg tccctttttt aaaaagtgat cactggtgtc ttcaagctgt 23161 ttgtatctgt gacaaagaaa aaacatctcg agctggaagc tccattcctt tatattgtca 23221 taaaacttat caaggtacgg gttatcctct acaatctcat tgatcatagg gaatccgaat 23281 ttttgtgaga gcatcgttgc gagagttgtt tttcctgccc cgataggacc ttctattgca 23341 ataaaagggg ctgtattcat cggaatcctc cttatatctg aaaaacgtgc gtcagttacc 23401 gaccttcata ttgtatcaca acccttgggt gcccccatga aaaaaagacg tttccaaatt 23461 atcgaaacgt ctttttgaca acattaaatt gatcagacag cagcagccag ttttgtggaa 23521 aggaaagacc cagcttccaa tagctgatgc ctcttaaatt cagctcttta atcagattga 23581 attttgcttg aatcgagcgg gcatcctcga accatacctc gtgccttctg ttttctgcat 23641 cagtatagcg gaagaaagga gcttgagcgg tttggtcata ctgaatggaa gcattgttct 23701 gatcagctat gacaatggct tgctgagggc ttactgctct tgctggagtt ccccctgctg 23761 tatatggcag cgtccagtca tatccatata aattctggcc catgacaatt ttgttcgcag 23821 gcatttcagt caaagcatat tctatgacat cacggacagg tccaattgga gaaaccgctt 23881 gaggcggtcc gccgctatag ccccattcat atgtcatgag aacaacaaag tcgacaattt 23941 cgccatgtgc cctgtaatca tgagcttcat accacctgcc ctgctgtgtt gcacttgttt 24001 taggagcaag agccgtagaa atttctaagc cctctcgatg gaaaagatcc cttgcttcgc 24061 ggaggaattg attataggcc tctctatcct ggggccgcaa atattcaaag tcgaaatgaa 24121 tgtcacggaa gccatatctt ctggcattct cgactatttc atttagaagc cgtcttttta 24181 cagtttcgtc gttcaaaagg atccggccaa gttcatcgct gaatgcctgg ttttctaggt 24241 tcgttataat catcatcaat gttgtatttt gactttctgt aatgctcctt aaattcgtta 24301 aaggcggtgc gactaaggtt ccgttccgct gtgcctggaa gctgaatgcg ccaaggtaag 24361 ttaagtaggg cgacgcttct ctggccgcct gctggagatt ttcgctgact tgatttcctc 24421 ggggctccaa ataagcattt gattcgatgt ctcgtttagg agctggaggg atgtataaac 24481 ggaaaccaat ctgaagcacg gtatttaact ggatgcggtt aacccttgcg agctcggctg 24541 ctgttgtatt gaactgccgg gcgatggatg tcagggtatc acctcgcttc acatcataga 24601 actggccagc tattggaatg acaatggttt gtccgacaac aaggctgtcg ggattcggta 24661 tttcattcgt ttcagtgatg tcatttgtgg ttgttctgta ttgtgaagcg atagcagaaa 24721 gagtgtcgcc ttgttttacc acataaattt gaatgaaaaa cgcctccttt catatcgcta 24781 tcaatgtatg aaagaaaagc gctgatcatg tttatttttc tataatttgt tcttccgtcg 24841 taatttctgc gaaaagaaca ttctccatca tggttaaggc gaattcgtta tcttcgtcac 24901 tgtttgacgc gatacagtcc ttaggaatcg tgatgctgta ttccctcata taagcgtcat 24961 tagcggtaaa cagcacgcat atattgccgg ctatacctgt tatgataata tgtctcacct 25021 gcaactcagt aagaagggtg tgaagtgctg tttcgtagaa agcggaatgt ttcggtttga 25081 ttaaaaaata atcagcatct accggagcta tctttgtgat gatatccttg cttctttcat 25141 ttgtgcattc ttgctgtatg tttttaatgt cagcttgcca aagtccataa tgatcattga 25201 tgtaaataat cggccattca ttttgtctcg cgtgctcctt taatgataaa atatgaggaa 25261 cgattttttc tgttttttta gcgagggttt cccccatatc gaattcaaaa ttattgatca 25321 tgtctacaat gagaagggct ttatctgctt tggacaatcg acagtctcct ttccgtttca 25381 gttatagtta atatgtagcc tttttaggca atgaaaaaac tttgaaaaga gagcttatcc 25441 ttatgacaca agatgaactt tatatgaaag aagcaattaa agaagcgaaa aaggctgaag 25501 agaaaggtga agtgccaata ggtgcggtgc ttgtcattaa tggtgaaatt atagcgcgtg 25561 cgcataattt aagagagact gaacagcgat ctattgccca tgcagaaatg cttgtaattg 25621 atgaagcgtg taaggcactc ggaacatggc ggctggaagg tgcgactctt tatgtgacgc 25681 ttgagccttg tccaatgtgt gctggtgcag tcgtactttc tcgagtggaa aaagtggttt 25741 ttggcgcatt tgatccgaaa ggcggctgtt caggcacgct aatgaacctt cttcaggagg 25801 aacgctttaa tcatcaggct gaagtggtga gcggtgtgct tgaggaagaa tgcggcggaa 25861 tgctcagtgc gtttttcaga gaactaagaa aaaagaagaa agccgccagg aaaaacttgt 25921 ctgaatagta cggttgcaat ttttagggga aacagatata cttaagtgtg catcgtaata 25981 gatgcaacat aaaatttgat atttattttg ccgtgctaag cggggaggta gcggtgccct 26041 gtacctgcaa tccgctctag cagggccgaa tcccttctcg aggttcgttt actttaaggc 26101 ctgccttaag taagtggtgt tgacgtttgg gtcctgcgca atgggaattc atgaaccatg 26161 tcaggtccgg aaggaagcag cattaagtga aacctctcat gtgccgcagg gttgcctggg 26221 ccgagctaac tgcttaagta acgcttaggg tagcgaatcg acagaaggtg cacggtaaat 26281 caatcatcaa attttcagac tcacctaata ttaggtgagt tttttgttat gtaaaaagag 26341 cttttggaat cgaaacaagg ttcatgtata atgggaatga tgaataacgg aggagggcaa 26401 acccgtgagt taccaagctt tatatcgagt attcaggcct cagcgctttg aagatgtggt 26461 cggacaagaa cacattacaa aaacgctgca aaatgccctt ttgcaaaaaa agttttctca 26521 cgcctatctg ttttccgggc ctagaggaac cggaaaaacc agtgcagcca aaatatttgc 26581 taaggctgtc aactgtgaac atgctcctgt tgatgagcca tgcaacgaat gtgcggcctg 26641 taaagggata acaaacgggt caatatccga tgtcatagaa attgacgccg cttctaataa 26701 cggtgttgat gagattcgtg acattcgcga taaagtgaag tttgccccat cggccgtcac 26761 atataaggta tatatcatag atgaggtgca tatgctttct atcggcgctt ttaatgcatt 26821 actaaaaaca ttagaagagc cgcctgagca ttgtattttc atattagcaa caactgaacc 26881 gcacaaaatt cctttaacca ttatctctag atgtcagcgt tttgacttta aacgaattac 26941 ctcccaagcg attgtaggcc gcatgaataa aattgttgat gctgaacagc tgcaagtgga 27001 ggaaggatcg ctggaaatca tcgcgagtgc tgcagacgga gggatgaggg atgccctgag 27061 ccttcttgat caggccatat cattcagcgg cgatatcctg aaagtcgaag atgcgctttt 27121 aattacgggt gctgtttctc aattatatat cgggaagctt gcaaaatccc tgcatgataa 27181 aaacgtttct gacgcactgg aaacattaaa tgaattgctt cagcaaggaa aagatccagc 27241 taagctgata gaagatatga ttttctattt cagggacatg ctgctgtaca aaacagcccc 27301 tggcttagag ggagtgcttg agaaagtaaa agtcgatgaa acgttccggg aactaagtga 27361 acaaattccg gctcaggccc tatatgaaat gattgatatt ctgaacaaga gccatcagga 27421 aatgaaatgg acaaatcatc cgcgtatctt tttcgaagtg gccgttgtga agatttgcca 27481 aacctcacat caatctgctg ctgatctccc ggaagtggat atgctgatga aaaaaatcca 27541 gcagctcgaa caggaagtag agcggctcaa aacaacgggc ataaaagcag ctgcggaaag 27601 cccgaaaaaa gaagcgccgc gtgtgccaaa gggcgggaaa tccaattaca aagcgccagt 27661 aggcagaatt catgagattt tgaaggaagc cacaagaccg gatcttgatc tgctcagaaa 27721 cagttggggc aagcttcttg ctcatctcaa acagcaaaac aaagtatcac atgccgcttt 27781 gctgaatgac agtgaacctg tggctgccgg atcggcggca tttgttctga aattcaaata 27841 tgaaattcat tgtaaaatgg tcgctgagga taacaacgga gtccggacta atcttgagca 27901 gattttagaa tcgatgctcg gaaaaagaat ggatttgatt ggcgttccag aagcacaatg 27961 gggtaaaata agagaagaat ttttagaaga tcatcagcag gaaaatgaag gatcaaatga 28021 accggctgaa gaagacccgc ttattgccga agcgaaaaag cttgttggag cggatttaat 28081 tgaaataaaa gactaacaaa atgaaagaga gtgaatgcta tgcgtggcgg aatgggtaat 28141 atgcaaaaaa tgatgaaaca aatgcaaaaa atgcaaaagg acatggcgaa ggctcaagaa 28201 gagcttgcag aaaaggttgt tgaaggaact gcaggcggcg gtatggtaac agtaaaagca 28261 aacggccaaa aagaaatcct ggatgttatc atcaaagaag aagtcgttga tcctgaagat 28321 attgatatgc ttcaagattt agtgcttgct gcaacgaatg aagctttgaa aaaagttgac 28381 gaaatcacaa acgaaacaat gggtcaattt acaaagggaa tgaacatgcc aggtttattc 28441 tagggggata aaagaacatg caatatcctg aaccaatatc aaagctgatt gacagcttta 28501 tgaaattgcc agggatcgga ccgaaaacag cggttcgtct ggcttttttt gttctaggta 28561 tgaaagaaga tgtagtatta gattttgcga aagcattagt aaatgcgaaa cgcaacctga 28621 catattgttc agtttgcggg catattacag atcaggaccc ttgctatata tgtgaagata 28681 cgcgcaggga taagtctgtt atctgtgttg tgcaagaccc taaagacgtt atcgctatgg 28741 agaaaatgaa ggaatacaac ggacagtatc acgttcttca cggcgctatt tctccaatgg 28801 acggcatcgg accggaggat attaaaatac cagaattgtt aaaacgatta caggatgatc 28861 aagtgacaga agtgatcctc gcgacaaacc ctaatataga aggggaagca acagcgatgt 28921 atatatcaag gctcctcaag ccgtctggta ttaagctctc ccgtattgcc cacggactgc 28981 ccgtcggcgg tgatttggaa tatgctgatg aggtcactct ttctaaagca cttgaaggaa 29041 gacgtgaatt gtaaggagga aaaagcgatc catgggtttt cttcgcaaga aaacattaag 29101 aagagagttt gatgaaaaac taaccgagca gctttttaag caaaaggaag agtggaacag 29161 gcaaaaaaag ctggttgaaa aaagcttaga accgtctgct gaagtgttat acgaactgaa 29221 agtagctgaa gcgaagtatt ttttttactt aagggaagcg aagcagcgaa atttaaaaat 29281 cagccggtgg aagtaagtgg tctaaactcc tggatcttct cataagcttg tactagaaca 29341 agcgaaggag atgagaagat tcatggagcc tatttttatt attgggatta ttttaggact 29401 ggttattctt ctttttttat caggttcagc agcgaagcct ttaaagtgga ttggcatcac 29461 agctgttaaa tttgtggcag gtgctttgct gctggtttgt gtaaatatgt ttggcggcag 29521 tcttggcatt catgtgccga ttaatctggt tacaacagct atcagcggaa ttttaggaat 29581 acccggaata gctgcgttag tcgtcattaa gcaatttatc atttaattga tattatgtat 29641 tgacttagac aactgaaggt gttattctaa tatacgtcgc tgatgacgaa cagctttttt 29701 gaaaagaaaa tgctaaaaag ttgttgacag tagcggcggt aaatgttatg ataataaagt 29761 cgcttaaacg agcggtaaac aaagttcttt gaaaactaaa caagacaaaa cgtacctgtt 29821 aattcatttt tataaatcgc acagcaatgt gcgtagtcag tcaaactact ttatcggaga 29881 gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa gtcgagcgga 29941 cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg tgggtaacct 30001 gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt tgtttgaacc 30061 gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc cgcggcgcat 30121 tagctagttg gtgaggtaac ggctcaccaa ggcgacgatg cgtagccgac ctgagagggt 30181 gatcggccac actgggactg agacacggcc cagactccta cgggaggcag cagtagggaa 30241 tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga aggttttcgg 30301 atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg gtaccttgac 30361 ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 30421 gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct taagtctgat 30481 gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt gagtgcagaa 30541 gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag gaacaccagt 30601 ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg gggagcgaac 30661 aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt tagggggttt 30721 ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta cggtcgcaag 30781 actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt ggtttaattc 30841 gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta gagataggac 30901 gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga 30961 tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc attcagttgg 31021 gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg tcaaatcatc 31081 atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag ggcagcgaaa 31141 ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt ctgcaactcg 31201 actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg aatacgttcc 31261 cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga agtcggtgag 31321 gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga agtcgtaaca 31381 aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat tttacggaat 31441 ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt gaaggaactt 31501 tgttccttga ataagttaag atgggcctgt agctcagctg gttagagcgc acgcctgata 31561 agcgtgaggt cggtggttcg agtccactca ggcccaccat cttatataac ggggccttag 31621 ctcagctggg agagcgcctg ctttgcacgc aggaggtcag cggttcgatc ccgctaggct 31681 ccaccaacgt gttctttgaa aactagataa cagtagacat cacattcaat tagtaacaca 31741 agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg gtggatgcct 31801 tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg agctgtaagc 31861 aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg agtggtatcc 31921 atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat ctaagtaccc 31981 ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg gattagccca 32041 aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac aaaggaacga 32101 ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt agtcaaaact 32161 tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg tcggaatccg 32221 ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc agtaccgtga 32281 gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc gtgtgcctac 32341 aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa ccggcgagtt 32401 acgatcccgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga gtctgaatag 32461 ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt ccagggtgaa 32521 gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc ggggatgagg 32581 tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc cgaaatagct 32641 ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac taggggcccc 32701 taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt gggagtcaga 32761 ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag ctaaggtccc 32821 aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga tgttggctta 32881 gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact ctgcgccgaa 32941 aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac agtggtagga 33001 gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt agaagtgaga 33061 atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc ctaaggtttc 33121 ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg aaaggcgtag 33181 gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc aatgggggga 33241 cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt aggctgggaa 33301 ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata tagtagcgaa 33361 gttcctgatt ccacactgcc aagaaaagcc tctagcgagg tgagaggtgc ccgtaccgca 33421 aaccgacaca ggtaggcgag gagagaatcc taaggtgatc gagagaactc tcgttaagga 33481 actcggcaaa atgaccccgt aacttcggga gaaggggtgc tctgttaggg tgcaagcccg 33541 agagagccgc agtgaatagg cccaggcgac tgtttagcaa aaacacaggt ctctgcgaag 33601 ccgtaaggcg aagtataggg gctgacgcct gcccggtgct ggaaggttaa gaggagcgct 33661 tagcgtaagc gaaggtgcga attgaagccc cagtaaacgg cggccgtaac tataacggtc 33721 ctaaggtagc gaaattcctt gtcgggtaag ttccgacccg cacgaaaggc gcaacgatct 33781 gggcactgtc tcaacgagag actcggtgaa attatagtac ctgtgaagat gcaggttacc 33841 cgcgacagga cggaaagacc ccgtggagct ttactgcagc ctgatattga atgttggtac 33901 agcttgtaca ggataggtag gagccttgga aaccggagcg ccagcttcgg tggaggcatc 33961 ggtgggatac taccctggct gtattgacct tctaacccgc cgcccttatc gggcggggag 34021 acagtgtcag gtgggcagtt tgactggggc ggtcgcctcc taaaaggtaa cggaggcgcc 34081 caaaggttcc ctcagaatgg ttggaaatca ttcgcagagt gtaaaggcac aagggagctt 34141 gactgcgaga cctacaagtc gagcagggac gaaagtcggg cttagtgatc cggtggttcc 34201 gcatggaagg gccatcgctc aacggataaa agctaccccg gggataacag gcttatctcc 34261 cccaagagtc cacatcgacg gggaggtttg gcacctcgat gtcggctcat cgcatcctgg 34321 ggctgtagtc agtcccaagg gttgggctgt tcgcccatta aagcggtacg cgagctgggt 34381 tcagaacgtc gtgagacagt tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga 34441 gctgtcctta gtacgagagg accgggatgg acgcaccgct ggtgtaccag ttgttctgcc 34501 aagggcatcg ctgggtagct atgtgcggac gggataagtg ctgaaagcat ctaagcatga 34561 agcccccctc aagatgagat ttcccattcc gcaaggaagt aagatccctg aaagatgatc 34621 aggttgatag gtctgaggtg gaagtgtggc gacacatgga gctgacagat actaatcgat 34681 cgaggactta accacatttt gaatgatgtc acacctgtta tctagttttg agagaacacc 34741 tctctaaagg cggaaggtaa ggaaactccg ctaagggctc tcacatcctg tgagaaacgc 34801 ccagtacctt catcctgaag gcatttgttt ggtggcgata gcgaagaggt cacacccgtt 34861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 34921 gtgagagtag gacgccgcca agcaagctta aacccagctt aatgagctgg gttttttgtt 34981 tactcaagat cgagaaaatc aaacaaatac aaacaccgag ggcttatata gcccatatac 35041 tgatttaaag tttcaaaaag gtctaaatag tgtatacaat atccgtttta aggggaggct 35101 aactgtacgg aggtggagaa gatggacgaa acagttaaac ttaatcatac atgtgtgatt 35161 tgtgatcaag agaagaatag aggcattcat ctttatacga aattcatatg cttagattgt 35221 gagagaaaag taatttctac atcaacttct gatcctgact atgcgtttta cgtaaaaaaa 35281 ctaaagagca ttcatacacc gccattatat tcatagacct gaaaaggtct ttttttgtac 35341 tcttaataat aaaaagaaga tgaaacttgt ttaaggattg aacgtagtag ataataatat 35401 taaaactgag tatagacaca ggagtcgatt atctcatgca gagatttttt cactttttgg 35461 tgtggagttt aactagcagt gcgacttttg ttttcattgg aatattgagc ttttttggtt 35521 taaaccagtc gattttttta tctattgttt atgggcttgc ttctggagca gccgtatata 35581 tagctggcat ctggaatgca agacggttat ttcttaaaaa gcatgaattg acaggaagag 35641 agtatgctta cattaagaaa aacttagagg aagcaaggca gaaaatggtc cgtcttagga 35701 aagccttgtt tcaggctaaa agcattcaaa tgtttaagca aaatgcagaa atgctaagga 35761 ttgtgagaag gatttatctc ctcaccaaaa aagagccaaa gcggttttat caggcagaac 35821 gattttttta tcaaactctc gattcggttg ttgaattgac agagaagtat gcttttctat 35881 catctcaccc aaaaaaaagc aaagaactgt cgatgtcgtt aagtgagaca cgcatcactc 35941 ttactgaatt gaccaagcgt ttagaggaag atttaactca agcaatgggt gatgaaattg 36001 acgagttgca gtttgaatta gacgcagcaa aacattcatt aaagaaataa gggaagaggg 36061 taagagcgat gaaccgagac caaagcgacc ttcatataga tgaattattg gcagatcctt 36121 ttggtggtaa catagagata ccaggttcgg aggctgtaaa agcagagaaa gagcaagtac 36181 ggcttgttga tgttcttcct gaggaaaaca aggaaaaagc aattcagctt gctggacaga 36241 ttgatcataa aaatatgcaa agcattgtct tatacggttc acaagctcaa tctaaactgc 36301 tgaacttttc tcatgatatg attaatcatg ttcaaaagaa ggatgtcggg gagattggcg 36361 aaatacttgg agagctgatg aaaaagctgg agcaagtaaa tcctgatgat ctccaatcta 36421 agaaaaaggg ttttttggca cgcatgtttg gaagagtatc aagttctctt caagaggtgc 36481 tgtctaaata ccaaaagacc agtgtgcaga tagacagaat cagcttgaag ctggagcact 36541 ctaaaaatgc tttaatcagt gacaacaagc tgttagagca gttatatgaa aaaaataaag 36601 aatatttcgc agcgctgaat gtttatattg ctgcaggaga actgaagctg gaggaattaa 36661 aaacaaaaac gattcctgaa ctgaagcaac aggctgaatc gagtgatcat aaccaaatgg 36721 ccgttcaaga ggtgaatgat ttaattcaat ttgctgaccg gttagataaa agggtgcatg 36781 atttgctgct gagcaggcaa attacaatcc aaagtgcacc gcaaatcagg ctgattcaaa 36841 atacaaacca agcgttagct gaaaagattc agtcatccat tgtgacagcg attccgttat 36901 ggaaaaatca agttgccatt gcactgacgc ttttaaggca gcgcaatgca gtggatgcac 36961 agcagaaagt atctgataca accaatgagc ttttgctgaa aaatgcggag cttttaaaaa 37021 ccaatacaat tgaaactgca cgggcaaatg aaagaggcct tgttgatata gataccttga 37081 agaaggtgca ggaaagctta ataagcacgc ttgaagaaac actgactata caagaagaag 37141 gacgaatcaa acgccgtcag gcagaagaag agctcatgat gatggaaggc gacctgaagc 37201 aaaagctgat tacaataaag gaaagatgat taccagtaag tctggcttta agttctgtca 37261 gaggcacgat ataataaggt gtaagaagac acattcaaag gattgttttc atgaacacac 37321 ctttatataa agcattaatt caacatgcga gaagaaattc tcattcattt catgttccgg 37381 gacatcacaa tggagatgtc ttttttgatg acgctaagtc aatattcgat ccgcttctca 37441 ccattgatgt aactgaactg gcaggactgg atgatctcca tcatccttct ggggtgatta 37501 aggaagctca ggagcttgcc agtcaattat atggatcggc ggaaagtttt tttctggtaa 37561 atggtacgac tgtcggaaac ttagcgatga ttttatctgt ttgtgaacct ggtgatacaa 37621 ttctggttca aagaaactgt cataaatctg tatttcatgc tgttgatttg tccggtgctg 37681 agccggttta tcttgcacct gacgttgatt cagcgatgca tgtgcctacg catgttccgc 37741 ttggaacaat taaagaggcc ctggaagcat atccagatgc gaaaggcttg gtactgacca 37801 atccgacata ttacggacat agtgctgatt tgactgagat cattactgaa gcccatcatt 37861 acgggattcc tgttttggtc gatgaagcgc atggcgcaca ttttatttta ggtgagcctt 37921 ttccggtctc agctttaaaa atgggggcag atattgttgt tcagtcggcc cacaaaacgt 37981 tgccagccat gacgatgggt tcttatttgc atctcaacag cagctgcagg attaacaggg 38041 atcgggtggc agagtattta aaccgattac aaagcagcag cccgtcttat ccgattatgg 38101 cttcgttaga tattgcccgc gcttatgtac agcatattat agaagaacaa aagctttctg 38161 acattctgca gcggatagaa acacttaaac aaacgtttga ttcacttaca aatgcagaag 38221 ctgttaaccc tgctaatcca ctgatcatca cggatccgct aaagctcaca attcgttcaa 38281 aacgcgggca ttctggctat acgctgcaaa gcattttaga gcgtgccaac atattcactg 38341 agcttgctga tgaaaatcaa gttctgctcg ttctcccatt gggaggaaaa cggagaataa 38401 acgctgaaat cattagaagc atcgatgaag agattgagaa aacgcctccg gatcagacgt 38461 ttgtttctgc agaatggggt gtgcagcctg ttactgtctt gccttatcca aaaaaggtct 38521 tacattcgtt taagaaagaa tatgtgagct ttgaggaagc agctggccgg cttaatgcag 38581 aagatatcat cccttatcct ccgggtatcc cgatgattat ggcgggagaa agaataacaa 38641 aagaaagtgt gcaaaagctc agccgcttga tcagcatgaa aacgcatgtt caagggaata 38701 tgaaaatcaa agagaaacaa ctacttgttt atatagaaga ggagaaatca tgagcggttt 38761 atttattaca ttcgaaggtc ctgaaggtgc agggaaaacg actgttctgc aggagatcaa 38821 aaacatactg acagcagaag gccttcaggt tatggcaact cgagagccag gcggaataga 38881 tattgcagaa caaattagag aggttattct gaatgagaac aatatattaa tggacccaaa 38941 aacagaagct ctcttatatg cggctgcaag acgccagcat ttagttgaaa aagtaaaacc 39001 tgctttagaa caggggttta tcgttctttg cgacagattc atagacagtt ctcttgcgta 39061 tcaaggatat gcaagagggc ttggaattga tgaggttctg tccattaatg aatttgccat 39121 tggagatatg atgccccatg taacggttta tttttcaatt gatccggaag aaggactgaa 39181 gcgtatttac gcaaacggct cacgggagaa aaacaggctc gatttagaaa aactggactt 39241 tcatacaaaa gtacaagaag gttatcaaga gctgatgaag cgatttccgg aaagatttca 39301 ttcagttgat gccgggcaat ccaaagacct cgtcgttcag gatgttctaa aggtgatcga 39361 tgaagcgttg aaaaaaattc aattgtgacc tgtttcccaa tagttgatat aataatgtaa 39421 acgagatcac gttgtttcca atctaaagga ggccttcaca gatgaaattg atagtggcag 39481 ttgtacaaga tcaggacagc aacagacttt tgaaaacctt aacggatcac aacttcagag 39541 tcacaaagct tgcaacgaca ggaggatttc ttaaatcagg caatacaacg tttatgatcg 39601 gtgtcgagga tatacgcgtc aataaagcgt tgagtctcat taaagaaaac gggcagaaac 39661 gtgatcagat gattgcccct gtatctccaa tgggtggaaa tgctgattcc tatgtccctt 39721 atccagtcga agttgaagtt ggcggagcga cagtatttgt ccttccagtc gatgaatttc 39781 atcaatttta aggatctgaa actgtgaaaa ttaataaaga tatacgtaca tttatagata 39841 ataagcagat tccctctgtg aaaacatctg agatcacagc atcgtttaaa acatcaatgg 39901 aaaaccaaag cagcaaaatg aagcttgatc agcttaccag gctgttatct gatatagaag 39961 catttggaaa aaggctaacg aaatctcgga attttaaaga cttagcgaga tttaaaggac 40021 ttgtgaaacg ttttgtcaaa gaagctgtgg acagcggtct ttcacatgaa acatcgaaaa 40081 gctttgacct ttacgggaac agcagaacgc tgggacttgt gaaagaaata gatgacaaat 40141 tgatacagct tacggaagag atgatggatc aggaaaaacc ggcaattgat ttgctggagc 40201 gtattggcga aataaaaggt ttattaatta acctttacac atagagagtg atacaatggc 40261 aatatcctgg aaggaaatga acgagcttca gcccagagtg atgaagcttt tatataatag 40321 tattgagaag gacagactat cacacgctta tttgtttgag gggaaaaaag gaacaggcaa 40381 gcttgatgcc gcgctgcttc ttgcaaaaag cttcttttgt ctggagggtg gcgcggagcc 40441 ttgtgagagc tgccgaaact gtaaacggat agagtcaggg aaccatcctg atctccatct 40501 tgttcagcct gatggcttat caatcaaaaa ggcgcaaatt caagcgctcc aagaagagtt 40561 ttctaagaca ggacttgaat cgcataaaaa gctgtatatt atttcgcacg cagatcaaat 40621 gacagcaaat gcggcgaaca gcctgctgaa atttttagaa gaaccgaaca aagacacaat 40681 ggccgtcctc atcactgagc agccccaaag gttattggat accatcattt caagatgcca 40741 aacccttcct tttcagcctt tgcagccgaa agcaattgaa gacagactga tcgaacagga 40801 cgtctcgcct catatggcaa ggcttctggc caacatgact aataatgtag cagaagcagt 40861 cgaattaagt cgaaatgatg agtttgcaga gtctagagcg aaagtgataa aattgtatga 40921 agtcctacac cagcggaaag gacatgcttt tttctttatt caagatcaat ggatgccctt 40981 tttcaaagaa aaaacccatc aagaaatggg tcttgatatg ctcttattga tatatcgtga 41041 tgtgttgtcc atccaaatag gaaatgaaga taaattgatt tatcaagact tattccaatc 41101 aataaaacag catgcgctac aatcaacaca acaaagcgtt acgaatcaga tacttgctgt 41161 tttagaagca aagaaacggc ttcattccaa tgtgaatgta caaggattaa tggagcactt 41221 ggtgttaatg ttgcaggagg gataagcttg tacaatgtaa ttggtgtccg ctttaagaaa 41281 gcgggtaaaa tatattattt tgatccgaat ggatttcata tagaacatga cagctgcgta 41341 attgtagaaa ctgtcagagg cgttgagtac ggccaggtcg taattgcaaa taaacaggtg 41401 gatgagcatg atgtggtgct tccccttcga aaagtgatac gtgtggcaga cgatcgcgat 41461 cttctcattg tagaagaaaa taaacaggaa gcactatcag catttgatat ctgccaaaag 41521 aaagtgattg agcatggctt ggatatgaag ctggtcgatg ttgaattcac gtttgatcgc 41581 aataaagtca ttttttactt cactgctgac ggccgagtcg actttagaga gcttgtaaag 41641 gatttggctt ctatctttaa gacaagaatt gagctgcgcc aaatcggagt gagggatgag 41701 gcaaaaatgc tcggaggaat cggtccttgc ggaagaatgc tttgctgttc aacgtttctt 41761 ggagattttg aacccgtttc cattaaaatg gccaaggatc agaacttgtc tttaaatcct 41821 acgaagattt cgggtctttg cggacgattg atgtgctgtc taaaatatga gaacgatgag 41881 tatgagacgg caaaagaaca gcttccggat ataggagaaa tgattacgac agcaaacggt 41941 cccgcgaagg tcgtcggact aaatattctg gaacgggtgc ttcaggtgga actgataaac 42001 cgtgaaaaag tgatagaata tacttgggaa gagctcttgg aagagggcgt cgtatccgca 42061 caaaccacag attaacgagg tgtggaacct tggataaaaa agagttattt gatacagtca 42121 ttaacttaga agaacaaatt ggctcactgt accggcagct gggggatttg aagcagcata 42181 tcggtgagat gattgaggaa aatcatcatt tacagcttga aaacaagcat ttgcgcaaac 42241 ggctggacga tacgacgcag cagattgaaa agttcaaagc tgataaaaaa gaatcaaaaa 42301 cacagaagac agagcaaact gatatagggg aaggatatga taatctggca cgtctgtatc 42361 aagaaggatt tcatatctgc aatgtccact atggaagtgt tcgaaaagag gattgtcttt 42421 tctgtctgtc attcttaaat aaaaaatagg gaaaaggctt ccgcataaga cgggagcctt 42481 tttcaaaggt actgaaagga taagaagatg gtttcattac atgatgatga aagattagat 42541 tatttgctgg cagaggacat gaaaatcata caaagcccaa cagtgtttgc tttttcgttg 42601 gacgctgtgc ttctgtccaa atttgcgtac gttccgattc aaaaagggaa aattgttgat 42661 ttatgcaccg gcaatggtat tgtgccgctg ctgctcagta caagatcaaa agcagacatt 42721 ctgggagtcg aaattcaaga aagactgcat gatatggctg ttcgcagcgt ggagtataat 42781 aagttggacg atcagatcca gatcatacat gatgacctga aaaacatgcc ggagaaactt 42841 ggacataatc gatatgatgt tgtcacctgc aatccgccgt attttaaaac gccgaaacaa 42901 actgaacaaa acatgaacga gcatctccga atcgcaagac atgaaatcca ctgcacgctg 42961 gaggatgtca tttcagtcag cagcaagctg ctcaagcaag ggggaaaagc agctcttgtt 43021 caccggccgg gaaggcttct ggagattttt gaactgatga aggcttatca aatcgagccg 43081 aaacgtgtac aatttgtcta tccgaagcaa gggaaagaag ccaataccat tttggttgaa 43141 ggtatcaaag gcgggcgccc ggatttgaaa attcttcctc ccttattcgt atatgatgaa 43201 caaaatgaat atacaaaaga aatcaggacc attttatatg gagacaaata accatttctt 43261 ctacgtcgtg aaatgtaagg acaatagctg gtatgccggg tataccaacg atctgcataa 43321 acgagtgaaa acgcacaatg atggaaaggg cgcaaagtac acaaaagtaa gacgtccggt 43381 tgaattaatt tttgccgaga gcttttcaac aaagcgggaa gctatgcagg cggaatatta 43441 tttcaaaaaa ctaactcgga agaaaaaaga gctttatata gaagaaaagc ggaacagcaa 43501 ggaggctgta tatgttaagg cgccaaatga gctttaatgg aaagtcggac atggggattc 43561 tttacttggt cccaacccca atcggaaatt tagaggatat gacattccgg gcgatcgaca 43621 cgctgaaatc agtggatgcg attgctgcgg aagatacgag gcaaacgaaa aagctttgtc 43681 atgtatatga aattgaaaca ccgctcgtca gctatcacga acacaataaa gaaagcagtg 43741 ggcacaaaat tattgaatgg ctgaaatcgg gaaaaaacat tgctcttgtc agtgatgccg 43801 gtctgccgac gatttctgat cccggagcgg aaattgtaaa ggattttacg gatataggcg 43861 gttatgttgt tccgttgccg ggagcaaatg ctgcattaac agctcttatt gcttcaggta 43921 ttgtaccgca gccttttttc ttttacggtt ttctcaacag acagaaaaaa gaaaagaaga 43981 aggagcttga agcccttaaa aaacggcagg aaacgatcat tttttatgaa gcgccccaca 44041 gattgaagga aaccttgtca gcgatggcag agatattagg agatcgggaa attgctgtaa 44101 cacgtgaact cactaagaaa tatgaagagt ttatccgagg aaccatatct gaggtcattg 44161 gatgggcaaa cgaggatcag atacgcggcg agttttgtct tgtcgtagaa ggaagtaata 44221 atgaagaggt agatgaggaa gaacaatggt gggaaaccct cactgcgaaa gaacatgtcg 44281 agcattacat ttcgaaaggc gctacgtcta aagaagctat taaaaaagca gcagtcgatc 44341 gcaatgtacc aaagcgtgaa gtgtacgatg cttaccatat taagcaataa aaaaacgttc 44401 ttgtgtcata acaagaacgt tttttgtaca agaaatgatt atttaaggtt ttgaagctgg 44461 ttttggattt cgctgatgat ttgctcagcg ccttctttac taagaaccaa tttaccgcct 44521 gcaagtttaa ggttatcatc agaaacttca ccagttactt ggcaagtcat gtttggttta 44581 tattttttaa ggatgatttt ttcatcatca acatagattt caagagcatc tttttctgcg 44641 attccaagag tacgacgcag ttcgatagga ataactacac gtcctaattc atcaacttta 44701 cgtacaatac cagtagattt cataaacatt ctcctcccaa gagatactta tttgtttaaa 44761 ttatattttt cttcgtcatt attcgacaaa atccttacct tcatagcata acaaggtttc 44821 caataatcgt caatcatttt gtttactatt gattgtaaga attagttctt atagtcagta 44881 atgtcttgga aactaccgaa ataacagcat tttataaata tttaataaag ctattatcct 44941 actaaaaatc cttttaaatc aagactttcg aaccaaagtt ttttatttca tttgattata 45001 tacgacaaaa ttcgacacga acagactttt tttattttca ttaaagattt ttaattttaa 45061 ttattctttt tcagggcgta tgtatatatt cttgatctta aaggctaaga tggtatcata 45121 gataaaggat aaatataaat aatattcata tatgatttgc acttatcgcc gctctcgtcc 45181 tttgggcggg agctttttga cattctgatt aggaggtttc aagatgccgc aagaaaacaa 45241 tacattttac attacaacac cgatttatta tccgagcgga aaattacata tcggccatgc 45301 atatacgaca gtcgcaggag atgcaatggc acgttacaaa agattaaaag ggttcgatgt 45361 tcgctattta acgggaacgg acgagcatgg acaaaagatc cagcaaaaag ctgaacagga 45421 aaacattaca cctcaggagt atgtggatcg cgcagcggca gatattcaaa aactgtggaa 45481 gcagcttgaa atctcaaacg acgactttat ccgcacgaca gaaaaacggc ataaagttgt 45541 cattgaaaaa gtgtttcaaa agcttcttga taacggggac atctatcttg atgagtatga 45601 aggctggtac agcatccctg atgaaacgtt ctacacggaa actcagctcg ttgatattga 45661 gcggaatgaa aagggagagg tcatcggcgg aaaaagccct gacagcggtc acccagttga 45721 attgatcaaa gaggaatctt atttcttccg catggggaaa tacgcggatc gtcttctgaa 45781 atactatgaa gaaaacccga cattcattca gccagaatca cgcaaaaacg aaatgattaa 45841 taactttatc aaacctggac ttgaggattt ggcagtatca cgtaccactt ttgattgggg 45901 cgtgaaggtg ccggaaaatc caaagcatgt tgtatatgtt tggattgacg cactatttaa 45961 ctatttaacg gcactcggtt atgatacaga aaatgatgag ctttatcaaa aatattggcc 46021 tgccgatgtt catttagtcg gtaaggagat tgtacgattc catactattt actggccaat 46081 tatgctgatg gcgctggatc ttccgctgcc aaagcaagta ttcgcgcatg gctggctttt 46141 gatgaaagac ggaaaaatgt cgaaatcaaa aggaaacgtt gtagatccgg ttacattaat 46201 tgaacgctat ggtttagacg aacttcgcta ttacttgctt cgcgaagtgc cgttcggatc 46261 agacggtgtt ttcacgccgg aaggatttgt tgagcgaatc aactatgatt tagcgaatga 46321 tttaggaaat ctattgaatc gtactgttgc gatgattaat aagtattttg acggacaaat 46381 cggttcttac aaaggtgctg ttacggaatt tgaccatacg ctcacttctg ttgctgaaga 46441 aacagtgaaa gcttatgaga aagcaatgga aaatatggag ttctcggtag cactttcgac 46501 tttatggcag ctcatcagcc gcacaaacaa atacattgat gagacagctc catgggtgct 46561 tgcgaaagat ccggcaaaag aagaagaatt gcgatcagtt atgtatcatc tcgctgaatc 46621 attgcgtatt tcagcggtac tgcttcagcc attcttaaca aaaacacctg aaaaaatgtt 46681 cgagcagctg ggcattactg atgaatcttt aaaagcttgg gacagcatta cagctttcgg 46741 ccagctgaaa gatacaaaag tacaaaaagg cgagccattg ttccctcgtt tagaggcaga 46801 agaagaaatt gcttacatca aagggaaaat gcaaggttca gcaccagcga aagaagaaac 46861 aaaagaagaa gagcctcaag aggtcgatcg tttacctgaa attacgattg atcaatttat 46921 ggatgtagag cttcgcgtag ctgaggtcat tgaggcagag ccagtgaaaa aagcagaccg 46981 tttattgaag ctgcagcttg atcttggttt tgaaaagcgc caagtggtat ccggcattgc 47041 gaagcattat acgcctgaag agcttgttgg aaaaaaactc gtttgtgtaa caaatctaaa 47101 accggttaaa ctcagaggag agctttctca aggtatgatc cttgcaggag aagcagacgg 47161 cgttttaaag gtcgtatcta tcgatcagtc gttaccaaaa ggcacaagaa ttaaataatg 47221 ataaacaaaa ggtgtttcac gtgtaacaat tcgtcgaaca ccttttgtgt ttcgacaaga 47281 aaggagtttt tcacttatgt tgtttgacac tcacgcgcat ttaaatgcag aacaatatga 47341 tactgatctt gaagaggtta ttgaacgggc aaaagctgaa aaagttgaac gaattgtcgt 47401 agttggtttt gaccgtccga cgattacccg tgcgatggaa atgattgagg aatatgattt 47461 tatttatgca gccattggct ggcaccctgt tgacgctatt gacatgacag aggaagactt 47521 agcgtggatt aaagagcttt ctgctcatga gaaagtggta gcgatagggg aaatgggact 47581 ggattatcat tgggataaat cacctaaaga tattcaaaaa gaggtgttta gaaatcaaat 47641 cgccttagcg aaagaggtca atttgcctat tatcattcat aaccgtgatg caacggagga 47701 tgtcgtgacc attttgaaag aggaaggcgc agaagctgtg ggcggaatca tgcactgctt 47761 tacaggaagt gcggaagtgg caagagaatg catgaaaatg aatttttatt tatcatttgg 47821 gggaccggtg acatttaaaa atgcgaagaa accgaaggaa gtagtgaagg aaattcccaa 47881 tgaccggctg ctgattgaaa cggactgccc gtttctcaca ccgcaccctt tccgcgggaa 47941 aagaaatgag ccaagctatg tgaaatatgt ggcagaacaa atcgccgaat taaaagaaat 48001 gacctttgaa gagattgctt ccatcacgac tgaaaatgcg aaaagacttt tccgtataaa 48061 ctgacaaaaa acgctagcgg gttttgtaag agcttgtccc ttacagcgtt tttctataaa 48121 agttctacat gctttcttct cctcatagga taggtttgtc gacaagtctt tcttccgttt 48181 ctcagtgtat ttcaggataa tgaagaggac actgagcttt tgggagaaag agaagggagg 48241 gttgacagcc ttttagatac tctatataat ctctccgagg agaaggaggc gtttttcatc 48301 acacaaaaaa tgaaaaagct gttttccgta aagcttagca aaagcaaagt cattctggtt 48361 gctgcttgtt tgcttttggc aggaagcggg actgcgtacg cggctcatga gctgacgaaa 48421 caatcagtct cagtttctat caatggcaaa aagaaacata tacgcacaca tgcaaataca 48481 gtcggtgatc ttttggagac gcttgatata aagacaagag acgaagacaa gatcacacct 48541 gctaaacaga caaagataac agcagacatg gacgttgtgt atgaggctgc aaaacctgtg 48601 aagcttacaa taaacgggga agaaaagacg ttatggtcaa cagcaaaaac ggtcggtgca 48661 ttactggacg aacaagatgt tgatgtgaaa gaacaagatc aaattgatcc cgcaatagat 48721 acagatattt cgaaagacat gaagattaac atagagcccg catttcaggt tactgtgaat 48781 gatgcaggga aacaaaagaa gatctggacg acttcgacta cggtcgctga ctttttaaaa 48841 cagcaaaaga tgaacataaa agacgaagat aaaatcaagc ctgcgttaga tgcaaagctg 48901 acgaaaggaa aggctgatat tacaattact cgtatcgaaa aggtcaccga tgtagttgaa 48961 gagaagattg cgttcgatgt gaaaaagcaa gaagacgctt ctcttgaaaa agggaaagaa 49021 aaggtcgtcc aaaaaggaaa agaaggcaag ctaaaaaaac atttcgaagt cgttaaagaa 49081 aacggtaaag aagtgtccag agagcttgta aaagaagaaa cagctgaaca aagcaaagat 49141 aaagtgattg ctgtcggcac aaagcaaagc agtccaaaat ttgaaacggt cagtgcttca 49201 ggtgattcaa aaacagttgt gtcccgcagc aatgaatcaa caggcaaagt catgactgta 49261 tcatctacgg cttatacggc aagctgcagc ggttgttcag gacatacagc gacaggcgtc 49321 aatttaaaaa ataatccgaa tgccaaagtc atcgctgtgg atccaaatgt cattccgcta 49381 ggctccaaag tccacgtgga aggctatgga tatgccattg ctgcagatac cggttcagcg 49441 attaaaggga acaagataga cgtctttttc ccagagaaat catcggcgta ccgatgggga 49501 aataaaacag tcaaaattaa aatcttaaat tagtatatac ttatgtattc agagggtttt 49561 gcgccctctg tttttttcgt tataatagac aaagtgcatt ttctgcttat tagacgctcg 49621 atataagaaa aagtttcatg aatatacaaa agtttttatt ttgtcttgga ggaaataatg 49681 aaaattaaag agatcattgt ggtcgagggg cgtgacgata cggcccgcat caaattggct 49741 gttgatgcag acacaattga aacaaatggt tcagccatcg atgatcatgt gattgaccaa 49801 atccgtttgg cccagaagac gagaggcgtc attattttaa cggatccgga ctttccggga 49861 gagaagattc gcaaaaccat ctcagaggct gtacccggct gtaagcatgc atttttgcca 49921 aaacatcttg ccaaacctaa aaacaagcgg ggaattggtg tggagcatgc atcggttgaa 49981 agcattaggg catgtttaga aaatgtgcat gaggagatgg aagcgcagcc gagtgacatt 50041 tcagctgagg atttgattca tgccggacta ataggcgggc ctgcggccaa atgccgccgg 50101 gaacgactgg gtgatctgtt gaaaatcggc tatacaaatg gcaaacagct tcaaaaacgg 50161 ctgcaaatgt ttcaaattaa aaaaagtgat tttatgagtg cgctcgatac cgttatgcgg 50221 gaggaacaga atgaataaag atattgcgac accgattaga acgaaagaga tactgaagaa 50281 atacggtttt tcttttaaaa agagcttagg acagaatttc ttaattgata cgaacatttt 50341 aaacagaatt gttgatcacg cggaagtgac ggagaaaaca ggtgtcattg aaatcggccc 50401 gggaatcggg gctttaaccg aacagcttgc caagcgggcg aaaaaggtcg tggcatttga 50461 gattgaccag cgattattgc cgattctgaa ggatacactg tcaccttacg aaaatgtcac 50521 tgtcattcat caggacgtgt taaaggctga tgtcaaatca gtcattgaag aacaatttca 50581 agattgtgat gagatcatgg tagttgccaa ccttccttat tacgtaacaa caccgattat 50641 catgaaactg cttgaagaac atcttccgct gaaagggatt gtggttatgc tgcaaaaaga 50701 agtggctgag cgcatggcgg ctgatccttc atctaaggaa tacggctcgc tttcaatcgc 50761 ggtgcagttt tatacagaag ccaaaacggt gatgatcgtc ccgaaaaccg tatttgttcc 50821 tcagcctaat gtcgattccg cagtcattcg tctgattctc cgagacggcc cggcagtgga 50881 cgtggaaaac gaatcctttt tctttcagct catcaaggca agctttgcac agcgccgtaa 50941 aacgctgctc aataacttag ttaacaatct gcctgaagga aaagcacaaa aatcaacgat 51001 tgaacaagtg ctcgaagaaa caaatattga cggtaagcgc cgaggtgaat ccctgtctat 51061 tgaggaattc gcagcgctgt ctaacggatt gtataaagcc cttttctaaa agggcttttt 51121 gttttgcgca ccacatggac tgccgctaca taggctagag aaggaccttt cattcaatga 51181 taagaaaaaa cttggactca gcgaaaaaag gcgctttctc aaggctcttt ctttcatgat 51241 gaggcttagt ctatgtgtgg agtgaggaac gtgcaatttc aaatagggga tatggtagcc 51301 agaaaatcct atcagatgga tgttttgttt cgaattatag gaatagagca aacaagcaaa 51361 ggaaattcaa ttgccatttt gcatggagat gaagtcaggc tgattgctga ttcggatttt 51421 tctgatctgg tggcagtgaa aaaggatgag cagatgatgc ggaaaaagaa agatgagagc 51481 agaatgaatg agtcgctcga attgctccgc caagattata agctgctcag agaaaagcag 51541 gagtactatg cgacaagcca atatcagcat caggagcatt atttccatat gccgggcaaa 51601 gtgcttcatc tggatggtga cgaagcatat ttgaaaaaat gcctgaatgt ctataaaaaa 51661 attggagtgc cggtctatgg catccattgc catgaaaaga aaatgtctgc ttctattgaa 51721 gtattgctcg acaaatatcg acctgacatc ctggtgatca cagggcatga tgcgtactcg 51781 aagcaaaagg gcggtattga tgatttgaat gcgtacagac attctaagca ctttgttgaa 51841 acagttcaaa cagcccgaaa aaagatccct cacttagatc agcttgttat ttttgcgggg 51901 gcctgccaat cccattttga atcactcatc agagcgggtg cgaattttgc aagttcaccg 51961 tcaagagtca atattcatgc gcttgatccg gtatatatcg tcgcgaagat cagctttacg 52021 ccgtttatgg aacggattaa tgtatgggaa gtgctccgta atacgctgac aagagagaaa 52081 gggcttggag gtattgaaac aagaggagtt ctgagaattg gtatgcctta taagtccaat 52141 taacagttga aaacctgcat aggagagcta tgcgggtttt ttattttaca taatgataca 52201 taatttaccg aaacttgcgg aacataattg aggaatcata gaattttgtc aaaataattt 52261 tattgacaac gtcttattaa cgttgatata atttaaattt tatttgacaa aaatgggctc 52321 gtgttgtaca ataaatgtag tgaggtggat gcaatggcga agacgttgtc cgatattaaa 52381 agatcgcttg atgggaattt aggtaaaagg ctgacgttaa aagcaaacgg tggccgccga 52441 aaaacgattg agcgttcggg cattttagct gagacgtacc cttctgtttt tgtgatacaa 52501 ctagatcaag acgagaactc gtttgaaaga gtttcataca gttatgctga tattttgact 52561 gagactgttg agctgacatt taatgatgac gccgcaagct cagtggcatt ttaacgggca 52621 gtgaaccttt tgtttactgc tttttgtttt gccctttttt ggtttccaat aattttaacg 52681 aaagttccat ctgatttaac aaaagataaa acagtcacat attatcgtga cgtgcacgaa 52741 tggctatcac ttctaaaaaa ggagttgttt cgtttgggca gacgtcgtgg agttatgtca 52801 gatgagttta aatatgagct ggctaaagac cttggttttt atgacacagt aaaaaatgga 52861 ggctggggtg aaattcgggc ccgcgatgcc ggtaacatgg tgaagcgtgc tattgaaatc 52921 gccgaacagc aaatggctca gaatcagaat aaccgataag gatgtgaccc gggggacgtg 52981 ctgttccctg gtttttttat tttggatata aatacataat gggctgaata tggatatgtt 53041 catcctgtac ttcaaatgtg atacaatgtt catacttatg tttagatgga gaagtaggtg 53101 aaagctatgc gtattttaga aaaagcgcca gctaagatca atctgtcact tgacgtcacc 53161 cgaaaacgcc cggatggcta tcatgaagtc gaaatgatca tgacgacaat tgatttagct 53221 gatcgaattg aattgacgga gcttgcagag gatgaagtga gggtttcctc ccacaaccga 53281 tttgtgcctg atgaccaaag aaacttagct tatcaggctg ccaagctgat caaggacaga 53341 tacaacgtga aaaagggagt ttccatcatg attacgaagg taattccggt ggctgccggt 53401 cttgccggcg gaagcagtga tgcggcggcg acactcagag ggctgaacag actgtggaat 53461 ttaaatctgt ccgcggaaac gcttgctgag cttggagcgg aaattggctc tgacgtttca 53521 ttttgtgtct atggcggaac tgcattagca acagggcgcg gcgagaaaat taaacatatc 53581 agcacgcctc cgcactgctg ggtcatttta gcgaagccga caatcggtgt ttcaactgct 53641 gaagtgtaca gagcgctgaa actggatggt atagagcatc ccgatgtaca aggcatgatc 53701 gaggcgatag aagaaaagag ttttcagaag atgtgcagcc ggttaggcaa tgtgcttgaa 53761 tctgttacac tcgatatgca tcctgaagtt gcgatgatca aaaaccagat gaaacgcttt 53821 ggtgcagatg ccgtgttaat gagcgggagc ggcccgacag tgtttggact ggttcagtat 53881 gagtcgaagg tgcagagaat ttataacggg ttaagaggct tctgcgatca agtttatgcg 53941 gtgagaatga tcggcgaaca gaacgctctt gattaaatcc gtatgttaag ttatattgat 54001 cttaaaatat tcggattttg ggggtgagtt catgaagttt cgtcgcagcg gcagattggt 54061 ggacttaaca aattatttgt taacccatcc gcacgagtta ataccgctaa cctttttctc 54121 tgagcggtat gaatctgcaa aatcatcgat cagtgaagat ttaacaatta ttaaacaaac 54181 ctttgaacag caggggattg gtactttgct tactgttccc ggagctgccg gaggcgttaa 54241 atatattccg aaaatgaagc aggctgaagc tgaagagttt gtgcagacac ttggacagtc 54301 gctggcaaat cctgagcgta tccttccggg cggttatgta tatttaacgg atatcttagg 54361 aaagccatct gtactctcca aggtagggaa gctgtttgct tccgtgtttg cagagcgcga 54421 aattgatgtt gtcatgaccg ttgccacgaa aggcatccct cttgcgtacg cagctgcaag 54481 ctatttgaat gtgcctgttg tgatcgttcg taaagacaat aaggtaacag agggctccac 54541 agtcagcatt aattacgttt caggctcctc aaaccgcatt caaacaatgt cacttgcgaa 54601 aagaagcatg aaaacgggtt caaacgtact cattattgat gactttatga aagcaggcgg 54661 caccattaat ggtatgatta acctgttgga tgagtttaac gcaaatgtgg cgggaatcgg 54721 cgtcttagtt gaagccgaag gagtagatga acgtcttgtt gacgaatata tgtcacttct 54781 tactctttca accatcaaca tgaaagagaa gtccattgaa attcagaatg gcaattttct 54841 gcgttttttt aaagacaatc ttttaaagaa tggagagaca gaatcatgac aaaagcagtc 54901 cacacaaaac atgccccagc ggcaatcggg ccttattcac aagggattat cgtcaacaat 54961 atgttttaca gctcaggcca aatccctttg actccttcag gcgaaatggt gaatggcgat 55021 attaaggagc agactcatca agtattcagc aatttaaagg cggttctgga agaagcgggt 55081 gcttcttttg aaacagttgt aaaagcaact gtatttatcg cggatatgga acagtttgcg 55141 gaagtaaacg aagtgtacgg acaatatttt gacactcaca aaccggcgag atcttgtgtt 55201 gaagtcgcga gactcccgaa ggatgcgtta gtcgagatcg aagttattgc actggtgaaa 55261 taataagaaa agtgattctg ggagagccgg gatcactttt ttatttacct tatgcccgaa 55321 atgaaagctt tatgacctaa ttgtgtaact atatcctatt ttttcaaaaa atattttaaa 55381 aacgagcagg atttcagaaa aaatcgtgga attgatacac taatgctttt atatagggaa 55441 aaggtggtga actactgtgg aagttactga cgtaagatta cgccgcgtga ataccgatgg 55501 tcgcatgaga gcgattgcat ccatcacgct ggatcacgaa tttgttgtac atgatattcg 55561 tgtgattgat ggaaacaatg gtcttttcgt tgcgatgccg agtaaacgca cccctgatgg 55621 agagttccgc gatattactc atcctattaa ttcaagcacg cgaggaaaga ttcaagatgc 55681 cgtgttaaat gagtatcatc gtctgggtga cactgaagca ttagaattcg aagaagctgg 55741 agcttcttaa aaaataacca aaaagcaagg actgctgaaa gggctgacat aagccttttg 55801 ccggcggtcc ttttttaatt ctgatttttc aaacttagtt gcactcaata gaaaattctt 55861 gcacttcatg aagtctcctt gaaatcagaa gatatttagg atatattttt ctatggataa 55921 aagggatatt ggaggccaat aaatggataa gcggtttgca gttgttttag cggctggaca 55981 aggaacgaga atgaaatcga agctttataa agtccttcat ccagtttgcg gtaagcctat 56041 ggtagagcac gtcgtggacg aagccttaaa attatcttta tcaaagcttg tcacgattgt 56101 cggacatggt gcggaagaag tgaaaaagca gcttggtgat aaaagcgagt acgcgcttca 56161 agcaaaacag cttggcactg ctcatgctgt aaaacaggca cagccatttc ttgctgacga 56221 aaaaggcgtc acaattgtca tttgcggaga tacgccgctt ttgacagcag agacgatgga 56281 acagatgctg aaagaacata cacaaagaga agcgaaagct acgattttaa ctgcggttgc 56341 agaagatcca actggatacg gccgcattat tcgcagcgaa aacggagcgg ttcaaaaaat 56401 agttgagcat aaggacgcct ctgaagaaga acgtcttgta actgagatca acaccggtac 56461 gtattgtttt gacaatgaag cgctatttcg ggctattgat caggtgtcta atgataatgc 56521 acaaggcgag tattatttgc cggatgtcat agagattctt aaaaatgaag gcgaaactgt 56581 tgccgcttac cagactggta atttccaaga aacgctcgga gttaatgata gagttgctct 56641 ttctcaggca gaacaattta tgaaagagcg cattaataaa cggcatatgc aaaatggcgt 56701 gacgttgatt gacccgatga atacgtatat ttctcctgac gctgttatcg gaagcgatac 56761 tgtgatttac cctggaactg tgattaaagg tgaggtgcaa atcggagaag atacgattat 56821 tggccctcat acggagatta tgaatagtgc cattggcagc cgtacggtta ttaaacaatc 56881 ggtagtcaat cacagtaaag tggggaatga tgtaaacata ggaccttttg ctcacatcag 56941 acctgattct gtcatcggga atgaagtgaa gatcgggaat tttgtagaaa ttaaaaagac 57001 tcaattcgga gaccgaagca aggcatctca tctaagctat gtcggcgatg ctgaggtagg 57061 cactgatgta aacctgggct gcggttcaat tactgtcaat tatgatggaa agaataagta 57121 tttgacaaaa attgaagatg gcgcgtttat cggctgcaat tccaacttgg ttgcccctgt 57181 cacagtcgga gaaggcgctt atgtggcggc aggttcaact gttacggaag atgtacctgg 57241 aaaagcactt gctattgcca gagcgagaca agtaaataaa gacgattatg tgaaaaatat 57301 tcataaaaaa taatcctaaa ttcggaggtt tatccatgtc taatcaatac ggagataaga 57361 atttaaagat tttttctttg aattcgaatc cagagcttgc aaaagaaatc gcagatatag 57421 ttggagttca attagggaaa tgttctgtca caagatttag tgacggggaa gtccaaatta 57481 atatcgaaga aagtattcgc ggatgtgatt gttacatcat ccagtctaca agtgaccccg 57541 ttaacgagca tattatggaa ctgctgatta tggtagatgc gttaaaacgc gcttctgcaa 57601 aaacgattaa cattgttatt ccttattacg gttatgcgcg tcaagacaga aaagcaagat 57661 cccgtgagcc aatcacagct aaacttttcg ctaacctgct tgaaacagcc ggtgcgactc 57721 gtgtgattgc acttgacctg catgcgccgc aaattcaagg attctttgat ataccgattg 57781 accacttaat gggtgttccg attttaggag aatattttga aggcaaaaat cttgaagata 57841 tcgtcattgt ttcaccagac catggcggtg tgacacgtgc ccgcaaactg gctgaccgac 57901 taaaagcgcc aattgcgatt atcgataaac gccgtccgcg tccaaacgtg gcggaagtca 57961 tgaatattgt aggtaacatc gaagggaaga ctgctatcct catcgatgac attattgata 58021 ctgcaggtac gattacactt gctgctaatg cgctcgttga aaacggagcg aaagaagtat 58081 atgcatgctg tacacaccct gtactatcag gccctgcggt tgaacggatt aataattcaa 58141 caattaaaga gcttgttgtg acaaacagca tcaagcttcc tgaagaaaag aaaattgaac 58201 gctttaagca gctttcagtc ggaccgcttc tggccgaagc gattattcgc gttcatgagc 58261 agcaatcagt cagctatctg ttcagctaaa ccatttttcg aggtttaaat ccttatcgtt 58321 atgggtattg tttgtaatag gacaactaaa acgacaagag gatggtgctg aatatggcaa 58381 ctttaacggc aaaagaaaga acggacttta ctcgttcgtc tcttcggaat atccgtactt 58441 caggacatgt tccaggtatc atatatggga aggatacggg taacaaacct gtgtcattag 58501 acagtgtgga gctcatcaaa acgctgaggg acgaaggcaa aaatgcagtc attacgcttg 58561 aggtcagcgg agaaaaacac tcagtcatgg taacagacct gcagacggac ccgctgaaaa 58621 atgaaatcac tcatgctgat tttcaagtag ttaatatgag tgaggacatt gaagtggaag 58681 ttccgattca tctgaccgga gaagccattg gagtgaaaaa cggaggcgta ctgcagcagc 58741 cgttatatgc acttactgta aaggccaagc caaaagccat tccgcaaacg attgaggctg 58801 atatttcaag cctcgatgta aatgaagtac tgacgattgc ggatttgcct gctggcggtg 58861 actactcctt taatcatgaa tcagatgagg ttgtggcttc aatccttcct ccgcagcagc 58921 aggaagcagc tgaggtcgat gaagaggaat ctgccgatgc tcagcctgaa ggtgaaaacg 58981 aacaataata gcttaaggcg taaccctccc gcggttacgt cttttgtgct agaatgagaa 59041 gaattatagc ccgtttatga agacgggagt tatgtgacta agggaggatt cgccatgctt 59101 gtgattgccg gtctcggaaa cccggggaag aactatgaaa atacacggca taatgtcgga 59161 tttatggtga tagatcagct tgcaaaggaa tggaatatag agctgaatca aaataaattt 59221 aacggattat acggaaccgg atttgtttcc ggcaaaaagg ttctacttgt taaaccgctt 59281 acatatatga atttatcagg agaatgtttg cggcctttaa tggactacta tgatgtcgat 59341 aacgaagatt tgacagtcat ttacgacgac cttgaccttc cgactggcaa gatccgttta 59401 agaacgaaag gaagcgccgg agggcacaat ggcatcaaat cactgatcca gcatcttgga 59461 acgtccgagt ttgaccgtat ccgcatcgga atcggccggc ctgtaaacgg catgaaggtc 59521 gttgattatg tgttaggctc ctttaccaag gaggaggcac ctgagatcga agaagcggtt 59581 gataaatctg tgaaggcttg tgaggcttct ttgagtaaac cgtttttaga agtcatgaac 59641 gaatttaacg caaaggtata aaatgtaaca acaaagtcca tactacacca aaatgacttt 59701 ttcatcagga ggacccttgt atggctttgc attattattg tcgtcattgc ggagtgaaag 59761 taggcagtct cgaatcttca atggtatcga cagactcact tggatttcag cacttaacaa 59821 atgaggaaag aaacgatatg atttcttata aagaaaatgg agatgtccat gttttgacga 59881 tatgtgaaga ctgccaagag gcgcttgacc gaaatccgca ttaccacgaa tatcacacat 59941 ttattcaata aaaagctttg gtgtagacac tagaccaaag cgtttttctg ttctcgcagg 60001 aaacagagag gaggggccat atggacaaca ttcaaacctt tataaaagaa agcgatgact 60061 ttaaatccat catcaacggt ttacacgagg gcctgaagga acagctgctc gcgggtctgt 60121 cgggttccgc gcgttctgtt tttacttctg ctctggctaa tgaaacgaat aagcctatct 60181 ttctcatcac ccataactta tatcaagccc agaaagtaac agatgatctg acttcacttc 60241 tagaggatcg gtctgtcctt ttgtaccccg tcaatgaact catttcatca gaaatcgcag 60301 ttgcaagccc tgaattgcgg gcgcagcgat tagatgtcat taatagacta acgaatggag 60361 aagcgccaat tgtcgttgct ccggtagctg caatcagaag aatgctgccg cctgttgagg 60421 tgtggaaaag cagccagatg ctcattcaag taggccatga tattgaacct gaccagcttg 60481 cctcacggct ggtagaggta gggtatgagc ggtctgatat ggtttctgcg cccggggaat 60541 tcagtattcg cgggggaatc attgacattt atccgctgac ttcagagaat ccggtgagaa 60601 ttgaactttt tgacaccgag gtggattcaa tccgcagctt taattcagat gatcagcggt 60661 caattgagac ccttacctcg atcaatatcg gtcccgcgaa ggaattaatt atcagaccgg 60721 aagaaaaagc gcgggcgatg gagaaaatcg atagtggtct tgccgcgagc ttgaaaaaat 60781 taaaggctga caaacaaaaa gaaatacttc atgcgaatat ttctcacgat aaagaacgct 60841 tgtctgaagg ccagacagat caggagctcg tgaagtatct ctcatatttc tatgaaaagc 60901 ctgctagttt actagattat acacctgata atacacttct gattttggat gaagtcagtc 60961 ggattcatga gatggaagaa cagcttcaaa aagaagaagc ggagtttata acaaatcttc 61021 ttgaggaagg gaagattttg catgacattc gtttgtcatt cagcttccaa aaaatagtgg 61081 ctgagcaaaa acggcctctg ctgtactact ctttattttt gcggcatgta caccatacga 61141 gcccgcaaaa tatcgtcaat gtgtcaggcc ggcaaatgca gagtttccat ggccaaatga 61201 acgtgcttgc gggcgaaatg gagcgtttta aaaaatcaaa tttcactgtt gtgttcttag 61261 gagcaaacaa ggaacgtacg cagaaattgt catctgtttt ggctgattat gatatcgagg 61321 ccgccatgac agacagcaaa aaagcgcttg ttcagggaca ggtctatatc atggaaggcg 61381 agctccaatc gggatttgag ctgccgttaa tgaagcttgc cgttatcacg gaagaagaac 61441 tgttcaaaaa ccgtgtaaag aagaagccgc gaaaacagaa gcttaccaat gcagagcgca 61501 tcaaaagcta ttctgagctt caaattggag attatgtcgt tcatattaat cacgggatcg 61561 gaaaatacct ggggattgaa actcttgaaa tcaacggcat tcataaagac tatttaaata 61621 tacattatca gggcagtgac aagctttacg tccctgtaga acaaattgat caggtccaaa 61681 aatatgttgg ctccgaagga aaagagccaa agctgtataa attaggcgga agtgaatgga 61741 agcgggtcaa gaaaaaagta gagacatccg ttcaggatat tgctgatgac ttaattaagc 61801 tgtatgccga aagagaagcg agcaagggct atgcgttttc tcctgaccat gagatgcagc 61861 gtgaattcga atcggctttc ccttatcaag agactgagga tcagctccgt tctattcacg 61921 aaatcaaaaa agacatggaa agagaacgtc cgatggaccg cttgctgtgc ggagatgtgg 61981 gctacggtaa aacagaggtt gccatacgtg ccgcgtttaa ggcgatcggt gacggaaagc 62041 aggtagctct gctcgttccg acaaccattt tggcacagca gcactatgaa accataaaag 62101 agcgcttcca ggactatccg attaatatcg gccttctcag caggttcaga acgagaaaag 62161 aagcaaacga aacaatcaaa gggctgaaaa atggaacggt tgatatcgtc atcgggacgc 62221 atcggctgct atcaaaggat gtcgtgtata aagacttagg gctcctcatc attgatgaag 62281 agcagcgttt cggtgtaacc cataaagaaa agatcaagca aataaaagcc aatgttgatg 62341 tattaacgtt aacagcaacg ccgattccgc gtacgctgca tatgtctatg cttggcgtaa 62401 gggacctttc agtcatcgag actccgccgg aaaatcgctt ccccgtacag acgtatgttg 62461 tggaatataa cggcgctctt gtcagagagg cgattgaacg tgagcttgca cgcggaggcc 62521 aggtctattt cttgtacaac cgggtagagg acattgagcg gaaagcggat gaaatttcaa 62581 tgctagtccc tgacgcgaag gtagcatatg cgcatgggaa aatgacagaa aatgaattag 62641 aaaccgttat gctaagcttc cttgaaggag aatcagacgt tctcgtcagc acaaccatta 62701 tcgaaactgg cgtggacatc ccaaacgtca atacgctgat cgtatttgac gccgacaaga 62761 tgggactttc tcagctttac cagctgcggg ggcgtgtcgg ccgttctaac cgtgtggcgt 62821 atgcgtactt cacgtatcgc cgggataaag tgctgacaga agtggctgaa aaaaggctgc 62881 aggctattaa agaattcaca gagttaggtt ccggttttaa aatcgcaatg cgtgacttaa 62941 cgattcgcgg agccgggaat cttcttggtg cccagcagca tggcttcatc gattcggtcg 63001 gatttgacct ctattcacaa atgctgaagg aggccattga ggagcgtaaa ggagacacag 63061 cgaagacaga gcagtttgaa acagaaattg atgtcgagct tgatgcgtat attccggaaa 63121 cttatattca agacggcaaa cagaaaattg atatgtataa acgcttcagg tctgtggcga 63181 caatcgaaga gaagaatgag cttcaagatg aaatgatcga ccgctttgga aactatccaa 63241 aagaagtcga atacttgttt actgttgcag aaatgaaagt ctatgcgaga caggaacgtg 63301 tcgagctgat taagcaggat aaagatgctg tcagattgac gatttctgaa gaagcaagtg 63361 ctgaaattga cgggcagaag ctgtttgagc ttggcaatca atatggcaga caaatcggac 63421 tgggaatgga agggaaaaaa ctcaaaatct ccatacagac gaaaggccgt agtgctgatg 63481 aatggctcga caccgtgctg ggcatgctga agggcttaaa agatgtgaaa aagcaaacca 63541 tttcatcaac gtaaattttg ttactctctg gtgtatatta catttgatgt gacggatact 63601 aatttcaagc gaggcggaag gtacataaag taactgcttt aggtctttcc cacatgtata 63661 taccatcaaa tgaaagagag gcaccagaga tgaaagcaac cggtatcgta cgtcgtattg 63721 atgacttagg tcgggtcgtg attcctaaag aaattcgaag aactctgaga atcagggaag 63781 gcgatccgct tgagattttt gtagatcgtg acggagaagt gattttgaaa aagtactctc 63841 cgatcagtga gcttggagac tttgcaaagg agtatgcaga cgcgctttac gacagcctcg 63901 gccattcagt gctgatttgt gatcgtgatg tatatattgc cgtgtccggc agctccaaaa 63961 aagattactt aaacaagtca atcagcgaaa tgctggaaag aacaatggat cagcgcagct 64021 ccgtgcttga gagtgatgcg aaatcagtac agcttgtgaa tggaattgat gaggacatga 64081 attcttatac tgtaggccca attgtggcga acggtgatcc gataggtgct gtggtgatct 64141 tttcaaaaga tcagacaatg ggcgaagtag agcataaagc cgttgaaaca gcagctggat 64201 ttttggctcg tcaaatggaa cagtaggtct tattcctttc ttcgaaaata ggtatgtaaa 64261 gaacagctct ccttgggacg ctgttctttt tcatgcgtgc cgaaaaagga atccaagggt 64321 tgggatgtgg tataataacc tcgtttttat ttgtgccgcg gtaatacgtg aaccgtattg 64381 cccctgacgt tgggaaggag cttttggatg gacgattcaa taggcgttaa acggcattgg 64441 atttggcagg gggcttttgt tttaattctg gcaggcgtca tcacaaaaat tttaagcgct 64501 gtttacagag tcccgtttca aaacattgtc ggcgatgttg gattttatat atatcagcag 64561 gtatacccct ttcttggtat tgcggtcatg ctgtccacat caggatttcc agtcattatt 64621 tcaaagctga tgaatgatta tagtgaaaaa aatcatcaca ccatattaaa aatatcagcg 64681 ttgtttttgt ctttaatcgg tattttatta tttctttgtt tatatctggg tgctgttcct 64741 attgcactct ttatgggaga ttcgcatcta gccgtgttaa ttcaagtggc cgcatacgcg 64801 tttctgcttt tcccatttgt cgcgttgcta agaggcggtt ttcaggggcg gcacgaaatg 64861 ctcccttcag ccttatcaca gatgacagag cagtttctgc gtgttgcggt gctcttgggt 64921 ttatcatttt ggctcgtgaa aaagggagcc tcgctttata ctgcgggagc ggcagccgct 64981 tcaggctctc ttgccggaag tttggttgca ttgataatac tggggttttt ttggttcaaa 65041 acgaaaagag acaaccaaac ggataggcaa aacgaaaatg tcatcacaac aaaagaattg 65101 acgaaaaaac tgcttttata ttcggtcaca atttgtgtaa gcagtttgct gcttttgttt 65161 atccagcttg ttgatgcttt gaatttatat gcattgcttt cgggtggtga ggcaagcgaa 65221 gaagcaaaat gcctaaaggg gatctatgat cggggacaac ccttgttgca gctcggttca 65281 gtttttgccg taagcattgc gacgtcactc gttccgtata tttctatggc tgtaaaaaac 65341 aaagagctga agatcatgaa agaaaaaatc acgtcatctt tgaaactatg ccttgtgctc 65401 ggtacaggcg catcggctgg gttgatttgc attctaaagc cggtaaatat catgctgttt 65461 caaaatggag aagggacagg tgcgttacaa gtatttagct gctccatttt gtttgcatcc 65521 ttggcggtaa cggcagcggc agtcttacag ggagcgggat acacagtttt tcctgcgata 65581 gcggtgggcg cgggtgttgc ggtgaaatgg gtgttaaaca cacttttggt tccgcgctat 65641 gggattgaag gcgcatcgct tgcgacagcg gcttcctttg cggctgtcgc cggccttaac 65701 ttgtatcagc ttcggcaaaa ggaatggctc gataagctta gaggcgtttt gattccgatt 65761 attggatctg ctcttttgat gtcagctgtt ttgcttgcgt atacgcgtct ctggactttc 65821 ttgtttcctg caacaggaag aggagcggct gtgattgaga gtctttctgc tgttgccatt 65881 ggtggcgcgg tgtttattta ttgtatgatg agattgggaa tatttacaga tgaagagctg 65941 aacagtgtgc cattcggcag caagttaagc aaattcatga gaaggagaga acaaaatggc 66001 gggtaaaatt acagtcgtcg gacttggtgc cggagacatg gaccaattga caattggtat 66061 acacaagctg ctgacgaagg cagatacgct gtatgtcaga accaaggatc atcctttaat 66121 tgaggagctt gaaaaagaaa cgaagaacat ccgtttcttt gatgatatat atgagaaaca 66181 tgatcagttc gaggcggtat atgaagaaat tgcagatatc ctctttgaag cggcgcggcg 66241 tgaggacgtg gtttacgctg tgccgggaca cccttttgtc gcagaaaaaa cagttcagct 66301 gctgacggag cggcaggaaa aggaaaacgt tcaagtgaaa gtcgcggggg gacaaagttt 66361 ccttgatgcc acattcaatg tcttgcaaat tgacccgatt gaaggttttc aatttgtgga 66421 tgccggcaca ttgtccgcgg atgagcttga gctcagacat catctgatca tatgtcaggt 66481 ttacgaccaa atgacggctt ctgaagtcaa gctgacattg atggagaagc tgcctgatga 66541 ttatgaggtc gtcattgtga ctgcagcagg cagccgtggc gaggagatca ggacagtgcc 66601 attatttgag ctggaccgca atgtcgcttt gaacaactta acaagtgtgt atattccgcc 66661 gattaaagaa gagaagctgc tttatcacga attctccacg ttccgaagca tcatcagaga 66721 gcttcgcgga cctaatggat gtccgtggga taaaaagcag acgcatcagt cattaaagca 66781 gtacatgatt gaagaatgtt atgagcttct cgaagctatt gacgaagaag acacagacca 66841 tatgatcgaa gagcttggcg acgttttgct tcaggtcttg cttcacgcgc aaattggtga 66901 agatgaaggt tatttcacaa ttgatgatgt cataaaagga atcagtgaaa aaatggtccg 66961 aagacatccc catgtgttta aagatgttaa ggttcaggat gaaaacgatg ttttagccaa 67021 ttgggaagat ataaaaaagg ccgaaaaaaa tacatctgaa tcatcattac tagacagcgt 67081 accgaaaacc cttccagctc tttcgaaagc agctaaattg cagaaaaaag cagcgaaggt 67141 cggttttgac tgggaagacg tcagcgatat ttgggaaaag gtaagtgagg aaatgaagga 67201 attttcttct gaggtttctg aagctcctca cgaacacaat cttaaagctg agtttggcga 67261 cattttgttc gcgctggtga atgtagcccg cttctacaaa atagagccag aggaagcgct 67321 gaccatgact aatgacaaat tccggagacg gttctcgtac attgaggaaa cagcgaagga 67381 agagggagtc gagttggctg atatgtccct tgaggacatg gacaaactgt ggaatgaagc 67441 aaaagaaact gagaggagat catagatatg agattagata aatttttgaa agtatcacgg 67501 ctgatcaaac ggcgtacact agcgaaggaa gtagctgacc aaggacgaat ctctattaac 67561 ggaaaccaag ctaaagctag ctctgacgta aaaccgggag atgaactaac ggtccgcttc 67621 ggccaaaagc ttgtaacggt tcaagttaat gaattgaaag acacgacgaa aaaagaagaa 67681 gctgcaaaca tgtacacgat tctaaaagaa gaaaaactcg gcgaataggc ttgttctaaa 67741 aaaacccccc acctcataca atgcagtaat aatgctaaaa gtatcgagga tatgggggct 67801 gaatagatga attcatatta tgatcaaaaa ggttcttcgt ctgttccgga acagcatgat 67861 gtgacaatga aaggccggaa gcatttagat atttctgggg ttaagcatgt ggagagtttt 67921 gataacgaag aattcctgct ggaaacggtg atgggaatgc tctccgtcag aggccaaaac 67981 ctgcagatga aaaatcttga tgtggaaaaa gggattgttt cgattaaagg cagggtattt 68041 gatttagtgt acttagacga acaacaaggg gataaagcta aagggttttt tagcaagttg 68101 tttaaatgac gctgacgaca caattctata caatgctagc gatgtccggt atgggtctct 68161 ggcttggtgc ttcgcttgat acataccggc tctttgtcat tcgtgccaaa acagccagat 68221 ggctattatt tattcatgat attcttttct ggattatgca agggctgctt ttcttttatg 68281 tcttgcttca tgtaaatgag ggagaattca ggatttacat ctttttagcg gttctgctgg 68341 gcgttgcgac gtatcagagc ctttgcaaac gaatctatat aaaaatactg aaattcgtca 68401 tttaccttgt tgtttctgtt tatcaattct tcaaaaaact cattcagcac gtgttatttc 68461 gtcctattgt gtggacatgc ggagcgatca tctggctggc ggcattttta ttcaagaaaa 68521 catacagcct gataggtttt ctcctgctgt gtctatataa aatagtcatg gttctgtgtt 68581 ttccgatccg ttttatcgcg aaacaatgtt tgaaacttct tcctgtgaaa atgcgtctaa 68641 cttttagacg ttattttgaa aaaggtgcag gatttctcaa aaagaagaag aaactattga 68701 taaccataag aacgaccatc acacggtttt tgaagagatg aaaggaggac cgtctggttt 68761 gaatttttcc agggaacgaa cgataactga aatacaaaac gactataaag aacaagtaga 68821 acggcaaaat cagctgaaga aacgaagacg caaagggctg tacagacggt taactgtatt 68881 cggcgcccta gtattcctga cggcaattgt gctggcaagc tctgtatggt cccaaacatc 68941 ttcccttagt gcaaaagaag aaaagaaaga acagcttgaa aaagaactga aaagtttaaa 69001 gacaaaacaa acggatttaa aagaagaaat atccaaattg aaggatgagg attacgtcac 69061 agagcttgcc agaagggact tattcatgtc tggagacgga gaaattatct tcaatgtgga 69121 gaagaagagc aagtagcctt gttgacactt aaatttttat ttaggtataa ttaagcaaac 69181 gatcttttta taagcctaag gaggagcact ttttttatgt cgattgaagt tggcagcaag 69241 ttgcaaggga aaattacagg tattacaaat tttggagcat ttgttgaatt gcctggaggc 69301 tcaaccggtc tcgttcacat tagtgaggta gctgataatt atgtcaaaga cattaacgac 69361 cacttaaaag tcggcgacca agttgaagtg aaagtcatca acgttgaaaa agacgggaaa 69421 attggtttat ctattaaaaa agctaaagac cgtccgcaag ccagacctag aaatgatttc 69481 cgtccgaaag aatcttttga acagaaaatg aataagtttt taaaagacag cgaagatcgc 69541 ttgtcatctt taaaacgcaa tacggaatca aaacgtggag ggcgcggagc aagaagagga 69601 taacttgctg ctttctataa aataaatgaa gcatccgttc atcccgacgg atgctttttt 69661 attatcctca ttctctttaa gagtcagaaa attacaacat taaagtttct gttgacgaaa 69721 gagacaaacc tttgtattat ataacttgtg cttagaagca caaaacaata tggcggtgta 69781 gctcagctgg ctagagcgta cggttcatac ccgtgaggtc gggggttcga tcccctccgc 69841 cgctaccata tttgtttggc ccgttggtca agcggttaag acaccgccct ttcacggcgg 69901 taacacgggt tcgaatcccg tacgggtcat cctaacaaat cggtttctct tgcagaagcc 69961 gatttttttc atttttagac aacattccgg aaattctttt cataaacgaa tatcaaggca 70021 gaaaccgtcg aagatttctt tggtattgtt accttctttt gacaaaatcc tatctgtgct 70081 ttcgctataa tgacaggcaa cgaatataac aggtgggaga tgagaggaat ggaaaaagca 70141 gaaagaagag tgaacgggcc aatggcggga caagctttgg aaaaactcca atcgtttttt 70201 aacaggggca cgaagctggt gactcatcat ttgcattcac tgtttttcta taaaggattc 70261 atttatgttg tcatcggatt tttgcttgga cgggctttca tattatccga ggtgcttcct 70321 ttcgcacttc ctttctttgg agcgatgctt cttatcagaa gagacaaagc gttttatgcg 70381 gttttggctg tgcttgcagg tgcgctgacc atatctccaa agcactcatt gctcatactg 70441 gcggcattgc tggcattctt cgtattttct aaagtggctg ccttcattac cgacgatcgt 70501 gttaaagcgc tcccgattgt cgtgttcttc tccatggctg cagcaagagc cgggtttgtt 70561 tatgcccaaa atggcgtatt tacaacctat gattatgtaa tggctatcgt tgaggctgga 70621 ctatcgttta tcttaacact gattttcctt cagagccttc cgatttttac tgtgaaaaaa 70681 gtgaaacaat cattaaaaat agaggaaatc atttgcttta tgattcttat tgcctctgtt 70741 ttaacggggc tggctggctt gtcctaccaa gggatgcagg cagaacatat attggctcgt 70801 tatgttgtgt tgagtttttc ctttattggc ggagcaagca tcggctgtac ggttggggtt 70861 gtgaccggcc tgattcttgg cttggcgaat atcggaaacc tatatcaaat gagtctgctt 70921 gctttttccg gtttattggg cggtttgctg aaggaaggga aaaaagcggg tgcagcaatt 70981 ggtttgatcg ttggatcact tcttatatct ttatatggtg aaggctctgc cggtctgatg 71041 acaacgctct atgagtcatt aatcgcagtc tgcctgtttt tgctcacacc tcaatctatt 71101 acgaggaaag tggcgagata tattccggga actgtcgagc atcttcaaga gcaacagcaa 71161 tacgctagaa aaatccgtga tgtcactgct cagaaggtag accaattctc caatgtattt 71221 cacgcgctgt ctgaaagctt tgcaaccttt tatcaagcat cagacgaaca gacagatgac 71281 agcgaagttg atctgttctt aagcaaaatc acggagcatt cctgccagac gtgctacaag 71341 aaaaacaggt gctgggtaca gaactttgat aaaacatatg acttaatgaa acaagttatg 71401 cttgaaacag aggaaaaaga atatgcatca aaccgaaggc tgaaaaaaga gtttcaacag 71461 tattgttcta aatccaagca ggttgaagag ctgattgagg atgagctcgc acatcatcat 71521 gcccatttga cactcaagaa aaaagtccaa gacagcaggc gccttgttgc tgaacagctt 71581 ttaggcgttt ctgaggttat ggccgacttt tctcgggaaa taaaaagaga gcgagaacaa 71641 cactttctgc aggaagagca aatcatagaa gcgcttcagc atttcggaat tgagattcag 71701 catgtcgaga tctatagtct tgaacaagga aatatcgata ttgaaatgac cattccgttc 71761 agcggacatg gagaaagtga aaaaatcatt gctcctatgc tttctgacat tctggaggaa 71821 caaattcttg tgaaagccga acagcactct ccgcatccga atggatacag ccatgtcgcc 71881 tttggatcaa caaaatcata cagggtgtcc acgggagctg ctcacgctgc gaagggcggc 71941 ggccttgtct ccggtgacag ctacagcatg atggagcttg gagccagaaa atatgctgca 72001 gcaatcagtg acggaatggg caatggcgca agagcgcact ttgaaagcaa tgaaacgatc 72061 aagcttcttg aaaaaatcct tgaatcgggc attgatgaaa aaatagcaat taaaacgatc 72121 aacagcatac tgtctctaag gacaactgac gaaatatatt ccacgcttga cctatctatt 72181 atcgatcttc aagatgccag ctgtaaattt ttgaaggttg gatcgacgcc cagctttatc 72241 aaacggggtg accaggtcat gaaagttcaa gcgagcaatc tgccaatcgg tattattaat 72301 gaattcgatg tggaggttgt gagtgaacag ctgaaagcgg gtgacctctt aattatgatg 72361 agtgatggca tttttgaggg gcctaagcat gtggaaaatc acgacttatg gatgaagcgt 72421 aaaatgaaag ggttgaaaac aaatgacccg caggagattg ccgatttgct tatggaagaa 72481 gtcatccgca caagatccgg ccaaattgag gacgatatga ctgttgttgt cgtccggatt 72541 gatcacaata caccgaagtg ggcatccatt cctgttccgg caatctttca aaacaaacaa 72601 gaaatttcat aacgcttccg tataaatcaa atttcttctg gcgaagatgg gaatatatga 72661 atctgagaat cctcgtattc tccaggagga atgaatgtga acaacggaca tttaaatcaa 72721 attttgctga taacggatgg ctgctcaaac catggggaag acccgcttgc aatggctgct 72781 tttgctaaag agcaggggat tacggtaaat gtcattggta taatggaaga aaatcaaatt 72841 gaccctgagg caatgaagga agtcgaaggg attgcacttg ccggaggagg cgtgcaccaa 72901 gtcgtttatg catctcagct ttcacaaact gttcaaatgg taacaaagaa agcgatgacg 72961 caaaccttac aaggtgtagt caatcaagaa ctgaaacaga ttctcggaaa gaatgtggaa 73021 atggaagagc tttctccgga aaaacgcggc gaagtcatgg aagtggtaga cgagcttgga 73081 gaaacggtgc atcttcaggt tttggttctt gttgatacaa gtgcaagtat ggcgccaaag 73141 cttccaacag taaaagaggc gctgattgat ttgtctgtaa gcctcaattc ccgaattggg 73201 aataacgaat ttgcgatgtg tatatttccc gggaaaaaac aagaggtcga gcttgtgctg 73261 aactggacac cgaagctgca atctctttcc acactctttg caaagctttc gacaggcggc 73321 atcacgccga caggtccggc gattcgtgaa gcgacactgc agtttgaaaa aatacgctca 73381 agaaggggca tgctggcaga tgatgaacga cgctttgacg agtttggcat gtagcctcaa 73441 gccgggtacg acaatcaaag gcaagtggaa tggaaacact tatacattgc gtaaacagct 73501 tggtaaaggg gccaatggaa ttgtgtattt ggcagaaaca tcagatggac atgttgcctt 73561 aaaggtgagt gatgacagcc tgtctattac ttctgaagtg aatgtcttga aatctttctc 73621 aaaggcccag tccgttacga tggggccttc tttttttgat acggatgatg cctatattcc 73681 cagtgccaat acgaaagttt cattttatgc aatggaatac ataaaagggc cgctgctttt 73741 gaagtatgtc agtgataaag gagcagagtg gataccggta ttaatgattc agctgttatc 73801 cagcttatcg gtgcttcacc agcaaggatg gatattcggc gatcttaaac ctgataatct 73861 gatcgtaact ggtccgcccg caaggatccg ctgcattgat gtgggcggca cgacaaagga 73921 aggccgggcg ataaaagagt atacggagtt ttatgacaga ggctattggg ggtatggaac 73981 aagaaaggca gagccatcct atgatctgtt cgcagttgcc atgattatga tcaacagtgt 74041 gcataaaaaa gaatttaaga aaacgaacca gcccaaagaa cagcttaggt ctctcatcga 74101 aggaaacccg ctgcttcaaa agtataaaaa agcgcttttt tcagccttga acggagatta 74161 tcaatccgca gatgaaatga aaaaggatat gctagacgcg gggcaaaaag cagcacaaag 74221 aaaacagcct ataaaagcat caccgcagcc tgccacacga caaagacagc aaaaaccgcg 74281 ccaaggaaaa ataacgaaga cgcgatatac cccaaaacag aaaccggcta agtcgggggg 74341 gttatttgaa acaacgctta tcgtgatcag tgttttagcg ctttatttcg cctatattat 74401 ctttttctta atctgaatgg tgcaaactgc agagcctatg cttcttcttt gcttggaggg 74461 gttgaaagtg ttaggatatg aatatcttta aaatacctgc tcattgtgag gaggacattg 74521 tgaaaagtgt caaagatttt ttaaacaaac acaatcttac gttaaaaggg gcgacaatca 74581 ttgtaggcgt ttccggcggt ccggactcaa tggctcttct tcacgcgttg catacgttat 74641 gcggccgttc agcgaatgtt attgcagctc acgttgacca tcggttcaga ggtgcggaat 74701 ccgaggagga catgcgtttt gtccaagctt attgtaaagc tgaacagctc gtgtgcgaaa 74761 cggctcaaat caatgtaacc gcatatgcac aggaaaaagg actcaataag caggctgcag 74821 cacgcgattg ccgctaccag ttttttgagg aaatcatgtc gaagcaccaa gcggactatc 74881 tggctcttgc gcatcatggt gatgaccagg ttgaaacaat gcttatgaaa ctggctaagg 74941 gtacgcttgg aacgggactt gcgggaatgc agccggttag acgttttggg acagggcgga 75001 tcatcaggcc gttcttaacc attacaaagg aagagatcct tcactattgc catgaaaacg 75061 gcttgagcta ccggacggat gaaagcaacg ccaaagatga ctacacaaga aacagattca 75121 gaaaaacagt gctcccgttt ttgaagcagg aatctccgga tgtgcataaa aggtttcaga 75181 aagtgagtga agcactgacg gaagatgagc aattcttaca gtcattaacg aaagatgaaa 75241 tgaataaagt aatcacaagc cagtctaata catcagttga aatcaattcc tctcaattgc 75301 ttgccctccc gatgccttta caaagaagag gagttcaact aatattaaac tatctttatg 75361 aaaacgttcc atcatccttt tcagcccatc acattcagca gtttctcgat tgggcggaaa 75421 atggcggtcc ttcaggagta ctggactttc cgaaagggct gaaggtggtc aaatcatatc 75481 agacatgttt gtttacattt gaacaatggc agtgcaaaaa tgttcccttt gaataccaaa 75541 ttagcggagc tgctgatgaa acggcagtgc tccctaatgg atatctgata gaggcaaggc 75601 attatgcgga ctcgcctgaa gaacatggga atgctgtttt tatcacaagt gaaaaaaagg 75661 tgcgatttcc cttaacaatc cggacgagaa aagctggaga ccggatcaaa ctaaaaggga 75721 tgaacggctc aaaaaaggta aaggatatat ttattgataa gaaattgcct ctccaagaaa 75781 gagacaactg gccgattgtg acggacgcaa gcggtgaaat tatctggata cctggcttga 75841 aaaaatcaat ttttgaagat cttgtgattc caaacagcga ccgcattgta ttacaatata 75901 gacagcatga aaagtgtagg gggcaagcaa aatcatgatg aaacatgata tcgagaaagt 75961 actgatctca gaggaagaga tacaaaagaa agtaaaagag ttaggtgcag aattaacgag 76021 cgagtatcaa gatacatttc cgttggcaat cggtgtgtta aaaggagcac ttccttttat 76081 ggcggatctt atcaagcata ttgatacata tttggaaatg gatttcatgg atgtatcaag 76141 ctacggaaat tctacggttt cttctggaga agtaaaaatc attaaagatt tggatacatc 76201 tgtagagggc cgggacatct taattattga agatatcatc gacagtgggt taaccttaag 76261 ttatctcgta gagctcttcc gataccgtaa agcaaaatca attaagattg ttaccctttt 76321 ggataaaccg agcggaagaa aagcggacat caaagcagac tttgtcggtt ttgaagttcc 76381 tgacgcgttt gtagtgggtt acggacttga ttatgctgag cgctatcgca atctgcctta 76441 tatcggagtg ttaaaaccgg cagtttatga aagctgatcg gcagcctgct tccgagatgg 76501 ttattgtttg tattggaatg attttctatg gtactattga acatagttgt gcttactgtg 76561 ggaggaggta aggaatgaat cgggtcttcc gtaataccat tttttattta cttattttat 76621 tagtagtaat cggggttgtg agctacttcc agacctcaaa tccgaaaaca gaaaatatgt 76681 cgtacagtac gttcatcaaa aacctggatg acgggaaagt tgatagcgta tcggttcagc 76741 ctgtcagagg tgtttatgag gtaaaagggc agctgaaaaa ctacgacaaa gatcaatact 76801 ttttgactca tgttcctgaa ggaaagggag cagaccagat atttaacgct ttgaaaaaga 76861 cagacgtaaa ggttgagccc gcgcaagaaa caagcggatg ggtgacgttc ctgacgacca 76921 tcatcccatt tgtcattatc tttattctgt ttttcttcct gctcaatcag gctcaaggcg 76981 gcggcagccg tgtcatgaac tttggcaaga gtaaagcgaa gctgtataca gaggaaaaga 77041 aacgcgtcaa atttaaagac gttgcagggg ctgacgaaga aaagcaagaa cttgttgaag 77101 ttgttgagtt tctgaaagat ccccgcaagt ttgccgagct cggcgccaga ataccgaaag 77161 gcgtgctttt agtcggacct ccgggtaccg gtaaaacatt gcttgccaag gcttgtgcag 77221 gagaagccgg cgtacctttc ttcagcatca gcggatctga tttcgttgaa atgtttgtag 77281 gggtcggtgc ttcccgtgtg cgtgacttgt ttgaaaatgc gaaaaagaat gcgccttgtt 77341 tgatcttcat tgatgaaatt gacgcagtcg gacgccagcg tggcgctggt ctcggcggtg 77401 gacacgatga acgtgaacag acgctaaacc aattgcttgt tgaaatggac ggattcagcg 77461 ctaatgaagg aattatcatc attgctgcga cgaaccgtgc ggacatcttg gacccagcct 77521 tacttcgtcc gggacgtttt gaccgtcaaa tcacagtgga ccgcccagat gtcattggcc 77581 gtgaagctgt attgaaagtc catgcgagaa acaaaccgct ggatgaaacg gttaacctaa 77641 aatcaattgc catgagaaca ccaggcttct caggcgctga cttagaaaac ctcttgaatg 77701 aagctgcgct tgtagcggct cgtcaaaaca agaaaaaaat cgatgcgcgt gatattgacg 77761 aagcgacgga ccgtgtaatt gccggacccg ctaagaagag ccgcgttatc tccaagaaag 77821 aacgcaatat cgtggcttat cacgaaggcg gacacaccgt tatcggtctc gttttagatg 77881 aggcagatat ggttcataaa gtaacgattg ttcctcgggg ccaggctggc ggttatgctg 77941 ttatgctgcc aagagaagac cgttatttcc aaacaaagcc ggagctgctt gataaaattg 78001 tcggcctctt gggcggacgt gttgctgaag agattatctt cggtgaagtc agcacagggg 78061 cgcacaatga cttccagcgt gcgacgaata ttgcaagacg aatggttaca gaattcggta 78121 tgtcagaaaa actgggaccg ttgcaatttg gacagtctca gggcggtcag gtattcttag 78181 gccgtgattt caacaacgaa cagaactaca gtgatcaaat cgcttacgaa attgatcagg 78241 aaattcagcg catcatcaaa gaatgttatg agcgtgcgaa acaaatcctg actgaaaatc 78301 gtgacaagct tgaattgatt gcccaaacgc ttctgaaagt tgaaacgctt gacgctgaac 78361 aaatcaaaca ccttatcgat catggaacat tacctgagcg taatttctca gatgatgaaa 78421 agaacgatga tgtgaaagta aacattctga caaaaacaga agaaaagaaa gacgatacga 78481 aagagtaatt cgctttcttt ctaaaaaaac tgccggctga cgctggcagt ttttttatgt 78541 aaatgattgg ctcagctgcg gcttttacaa tcatccaatt ctggtatcga tttgtttaca 78601 aatgagccgc tgatcgtgta tggtattgta gaatgtttgt aaaaagtaaa gtagagaaac 78661 tattcaaaag tggtgataga ggttgttact ggttatcgat gtggggaaca ccaatactgt 78721 acttggtgta tatcatgatg gaaaattaga atatcactgg cgtatagaaa caagcaggca 78781 taaaacagaa gatgagtttg ggatgatttt gcgctcctta tttgatcact ccgggcttat 78841 gtttgaacag atagatggca ttattatttc gtcagtagtg ccgccaatca tgtttgcgtt 78901 agaaagaatg tgcacaaaat actttcatat cgagcctcaa attgttggtc caggtatgaa 78961 aaccggttta aatataaaat atgacaatcc gaaagaagta ggggcagaca gaatcgtaaa 79021 tgctgtcgct gcgatacact tgtacggcaa tccattaatt gttgtcgatt tcggaaccgc 79081 cacaacgtac tgctatattg atgaaaacaa acaatacatg ggcggggcga ttgcccctgg 79141 gattacaatt tcgacagagg cgctttactc gcgtgcagca aagcttcctc gtatcgaaat 79201 cacccggccc gacaatatta tcggaaaaaa cactgttagc gcgatgcaat ctggaatttt 79261 atttggctat gtcggccaag tggaaggaat cgttaagcga atgaaatggc aggcaaaaca 79321 ggaaccaaag gtcattgcga caggaggcct ggcgccgctc attgcgaacg aatcagattg 79381 tatagacatc gttgatccat tcttaaccct aaaagggctg gaattgattt atgaaagaaa 79441 ccgcgtagga agtgtatagg aggtttagta atggattatt tagtaaaagc acttgcgtat 79501 gacggaaaag ttcgggctta tgcagcgaga acgactgata tggtaaatga ggggcagaga 79561 cgccatggta cgtggccgac agcatccgct gcactaggcc gtacaatgac agcttcactt 79621 atgctcggcg ctatgctgaa gggcgatgat aagctgaccg tgaaaatcga gggcggaggt 79681 ccgatcggag ctattgtagc tgatgccaat gccaaaggag aagtcagagc ctatgtctct 79741 aacccgcaag ttcattttga tttaaatgaa caaggtaagc ttgatgtcag acgtgcggtt 79801 ggaacaaacg gaacgttaag tgtcgtaaaa gatttaggtt tgcgcgagtt cttcacagga 79861 caagtagaaa tcgtttcagg agaattagga gatgatttta cttactatct tgtgtcatct 79921 gagcaggttc cttcatcagt gggcgtaggt gtgctcgtaa atcctgacaa taccattctt 79981 gcggcagggg gctttattat tcagctgatg ccgggaacag atgatgaaac aatcacaaaa 80041 attgaacagc gtctatctca agtagagccg atttctaagc tcatccaaaa agggctgaca 80101 ccagaagaaa ttttagaaga agtcctaggc gagaaacctg agattttgga aacgatgcct 80161 gtcagattcc attgcccttg ttcaaaagaa cggttcgaaa cagccatttt aggactaggc 80221 aaaaaagaaa ttcaagatat gatagaagaa gatggacaag ccgaagcagt atgccatttt 80281 tgtaatgaaa agtacttatt tacaaaagaa gagctggaag ggcttcgtga ccaaactacc 80341 cgctaagctc tttagcgggt ttttaatttg agaaaagggg ctgaaagcag gtttgaaatc 80401 aagaacaatc tggaccatta ttttaggggc gctgttggtt tgctgtattg ctgttgcata 80461 tacgctgacg aaatcccaag ccggcgcatc gtcatccggt gagtctattg cgactatcgg 80521 aggcaagagt gtgacaagag aagaatggct gaaagaaatg gaagatcagt atggtaagtc 80581 aacgcttgaa gatatgatca atgtccgagt tgttgagcag ctggctaaaa agaacaaact 80641 taaaatatcc aaaagcgaag ttgatcgtga gtttttgctg attaaagcgg tcaataattc 80701 cttttacgaa gatgaacata cgacggagaa agagtggaaa gaccaaattc gttataatat 80761 cctccttgag gatttgttaa caagggatat cgatatctca aacaaagaat tggaatcatt 80821 ctataataaa aataaggaac tatatcagtt tgatgattcg tatcgaattc ggcacattgt 80881 tgtaaaagat gaagaagaag caagagaagt cctgaaagaa ctgaaaggcg gatcaagctt 80941 tgaagctgtc gctgccgaaa gatctacaga cagatataca tcaccatacg gcggagattt 81001 aggttttgtc acagaggcat cagacaacat tccatcagca tacattgaag aggcgaaaac 81061 actcaaagag gatgaatggt ctcaggaacc aataaaggtc agcaacggat atgccattat 81121 ccagctgaaa gaaaaactaa aggcaagaac gttctcattt gatgaagtaa aggaccagat 81181 cagacggcaa atcgcaatgg atcagctagg cgataaagcg acagttaaga cactttggaa 81241 agaagccgat gtatcttggt tttatgggga aaaaagtact aagtgattga caaaaaattt 81301 tgaaattgat agattatata cataatacca atacaaatag tcggaaattg aggtgtcgag 81361 aatggtacgt gtagcaaact ccattactga attaattggg aatacgccaa tcgttaaatt 81421 aaatcgcctt gcagatgaaa acagtgcgga tgtatatcta aaacttgaat acatgaaccc 81481 tggaagcagt gtaaaagacc gtatcggttt agctatgatt gaagcggctg aaaaagaagg 81541 aaaattaaaa gccggtaata caatcattga accgacaagc ggaaatactg gaatcgggct 81601 tgcaatggtt gctgctgcta aaggattaaa agccattttg gttatgcctg atacaatgag 81661 catggagcgc cgcaaccttc ttcgcgcata tggtgctgag cttgtgctga ctcctggtgc 81721 ggaaggcatg aaaggtgcta ttaagaaagc tgaagagctt gctgaaaagc acggatactt 81781 tgtgccgcag cagtttaaca acccttctaa ccccgaaatt caccgccaaa caacgggtaa 81841 agaaatcgtt gagcaattcg gtgatgatca gcttgacgca tttgtagccg gaatcggaac 81901 gggcggaacg attacgggag cgggcgaagt gctgaaggaa gcataccctt ccatcaagat 81961 ttatgctgtt gaaccgtcag attccccagt gctttcagga ggaaaaccag gcccccacaa 82021 aattcaggga atcggagcag gattcgtgcc ggacatctta aacactgaag tatatgatga 82081 aatcttccct gtgaagaatg aagaagcatt cgaatatgcc cgcagagctg cacgtgaaga 82141 aggaattctc ggaggcatct catcaggtgc ggcaatttat gctgctcttc aagtagcaaa 82201 aaaactcgga aaaggcaaaa aagtattggc catcattcca agtaacggcg aacgttatct 82261 aagcacgccg ctgtaccaat tcgattaaaa aaagccaaaa ctcccggttc gccgggagtt 82321 tttttatatt tcgtgcatca aatatgccat gtctgcgacg aatgttattc ttggaagaga 82381 aattcacttt tttcactaac aacattgctt tacaattaaa aacaagtaaa aaagaaaata 82441 gaggaatgat acaaatggca caacgcagac cggcaggcaa aaaaatacct tttcaaaaag 82501 actcattctt acaacaattt gagaaacttg cgcaatcccg gaaacatcat gtacttctcg 82561 aaagtgcaag aggcggcaga tatagtatag ccggtcttga tccaattgcg actgtgaaag 82621 gaaaagacgg aataactaca attaagcatg gtgatgagat gctgtttaaa gaaggtgatc 82681 cattacgggc cttccacagc tggtttaaaa cactggaaac agaaacgaat catgagttcc 82741 ctgactttca aggcggggca atcgggtttc tcagctatga ttacgcacgg tacattgaaa 82801 attttaaaat gctctcatta gatgatttag aaacaccaga tatttatttt cttgtttttg 82861 atgatatagc agtttatgac catcaagaag agtctctatg gctgattact catgttaatg 82921 gttctgatca ggaaacagcg gatgtgaagc tatctgagtt agagcagatg tggttgactg 82981 agcttcccgc tgtcacttcg cgagagatga agcctgaaac agctggttct ttcgcggcgc 83041 catttaccga ggatgggttc tcacaagctg tagagaaaat caaacaatac attgccagcg 83101 gagatgtgtt tcaagtcaat ctatcaataa ggcagtcaca gtcactgtct gtccacccat 83161 atcaaattta caaaaccttg agagaagtaa atccttctcc ttatatggcg tatttagaaa 83221 cacctgattt ccaaatcatt tgcggatcgc ctgaactgct tgtcagcaaa aagggcaagc 83281 tattagagac gagaccgatt gcgggcaccc gttccagagg gaaaacaaat gaagaagacg 83341 aggcgcttgc aaacgaattg atacacaatg aaaaagaacg cgcggaacat gtcatgctgg 83401 ttgatcttga gcgaaatgat ctgggaagag tatcacgtta cgggtctgtg cgcgtaaatg 83461 aattcatggc aattgaaaaa tactcgcatg tgatgcacat tgtgtctaat gtccaaggtg 83521 aactgcagga tgggtatgat gctgtagata ttattcatgc tgtgtttccc ggaggaacca 83581 ttactggtgc accgaaagta agaacgatgg aaattataga agaacttgag ccgacacgcc 83641 gagggcttta tactggatct ataggatggt ttggatataa tcacgatctg cagtttaata 83701 tcgtcattcg aaccatttat gcaaccggag ggcaggcatt tatgcagtcc ggtgcaggag 83761 ttgtgattga ttctgttccg aagcacgaat acaaggaatc attcaaaaaa gcttttgcga 83821 tgcaaagagc attagagctg agcgaagaag agacaaaaat tagatgaggt gagcggagaa 83881 atgattttaa tgattgataa ctacgattca ttcacgtaca acttggtaca gtatttgggc 83941 gagcttgggg aagagctggt tgtgaaacgc aatgacagca tcacaatcga tgaaattgaa 84001 gaactgtctc cggactttct gatgatatct cccggaccgt gcagccctga tgaggcggga 84061 atcagcctcg aagcaattaa acatttcgca gggaaaattc ctattttcgg tgtatgtctc 84121 ggacatcagt ccatcgcaca agtgttcggt ggtgatgttg ttagggcaga acggcttatg 84181 cacgggaaaa cctcggatat cgagcatgac ggcaaaacca tttttgaagg gttgaaaaat 84241 ccccttgttg cgacgcgata ccactcgctg atcgtaaaac ctgagacgct gccaagctgt 84301 tttacagtaa cagcacaaac gaaagaagga gaaatcatgg ctattcgcca caatgacctc 84361 ccgatagagg gtgtgcaatt tcacccagag tctattatga cctcctttgg gaaagaaatg 84421 ctcagaaatt ttattgagac atatcgcaag gaagttattg cgtgatgata tatgtgaacg 84481 gccggtatat ggaggagaaa gatgcagttc tttctccttt tgaccatggg tttttatatg 84541 ggatcggtgt tttcgaaacc ttcaggctct acgaaggctg cccgtttttg cttgattggc 84601 atatagagag gcttgaacgc gcgcttaagg atctgcaaat cgaatatact gtttcaaagc 84661 atgagatcct tgagatgctg gacaagctgc ttaagctaaa tgatatcaag gatggcaatg 84721 cccgcgtcag actgaacata tcagcgggaa tcagcgataa aggctttgtc gcccagacgt 84781 acgataagcc caccgtttta tgctttgtga atcagctgaa accagaaagt cttcctttgc 84841 aaaaagaagg aaaggtttta tcgatacgga gaaacactcc agagggatcg ttccggttaa 84901 aatctcatca ttatctaaat aatatgtatg cgaaacggga aattggaaat gatccgcgtg 84961 tcgagggaat tttcttaacg gaggatggag ctgttgcaga gggtatcata tctaatgtct 85021 tctggagaaa aggtcgctgt atctatacgc catcgcttga taccggtatt ctggacggcg 85081 tcacgagacg ttttatcata gaaaatgcaa aggatatcgg cctggagctc aaaacgggcc 85141 gatatgagct agaagctctc ttgacagctg acgaagcgtg gatgacgaac tcggttcttg 85201 aaatcatccc gtttactaaa atagaagaag taaactatgg aagccaaagc ggagaagcaa 85261 cctccgctct tcaattgtta tacaaaaaag aaataaagaa catgattcat gaaaagggag 85321 gaagagcatg gcgcagcaca caatagatca aacacaagta atccacacta agcccagcgc 85381 tttatcatat aaagagaaga cgctggtgat gggaatttta aacgtaacgc ctgactcttt 85441 ctcggacggc ggaaaatatg acagcttgga caaggcgctg ctgcacgcga aagagatgat 85501 cgatgatggt gcccatatca ttgatattgg aggggaatcg acaaggcctg gcgctgagtg 85561 cgtatctgag gatgaggaga tgtccagagt cattccggtg attgagcgga ttacgaaaga 85621 gcttggtgtt cctatttctg tagacacgta caaggcttct gtcgcagatg aagcagtgaa 85681 agccggtgca tccattatca atgatatttg gggagccaaa catgatccga agatggcttc 85741 cgttgcagct gaacataatg ttccaattgt actcatgcat aaccgccctg aaagaaacta 85801 caatgactta ttgccggata tgctgtcgga cttaatggag agtgtaaaaa ttgctgttga 85861 ggccggagta gacgagaaga acattattct tgatcctggt atcggtttcg cgaaaaccta 85921 tcacgataac ttggcagtga tgaacaaact agagattttc agcggattgg gatatccggt 85981 tcttctggca acctcccgaa aaagattcat cggacgtgtt ctggatcttc cgcctgagga 86041 gcgggctgag ggcacaggcg cgactgtgtg tctcggcatt caaaaaggct gtgacattgt 86101 cagggtccat gatgtaaagc aaattgccag aatggcgaaa atgatggacg cgatgctgaa 86161 taagggaggg gtgcaccatg gataaagttt atgtagaagg tatggagttt tacggatatc 86221 acggtgtgtt cacagaagaa aacaaacttg gccagcggtt taaagtcgat ttaaccgctg 86281 agctggattt aagcaaagct ggacagacag acgaccttga gcaaacgatc aactatgctg 86341 agctctatca cgtatgtaaa gatatcgtgg aaggggagcc tgtgaaattg gtggaaacgc 86401 tggcggaacg tattgctggc actgttctcg gaaaatttca gcctgttcag caatgtacgg 86461 tgaaagtgat taagccagac ccgccaattc ccggacacta taaatcagta gcaattgaaa 86521 ttacgagaaa aaagtcatga acaacatagc ttatattgca cttggatcta atattggaga 86581 tagagaaacg tatttaaggc aagcagtggc tttactgcat cagcatgctg cggtgacagt 86641 cactaaagtg tcgtctattt acgaaactga cccggtcgga tacgaagatc aagctcaatt 86701 tttgaatatg gctgttgaaa tcaagacatc attgaaccct tttgaactcc ttgaactgac 86761 gcagcagata gaaaatgaat taggcagaac aagggaagta agatgggggc cgcggacggc 86821 agaccttgac attttgttat ttaatcgtga aaatattgaa acagagcaac taattgttcc 86881 gcatccgaga atgtatgagc gtttgtttgt ccttgcgccg cttgcggaaa tttgccagca 86941 ggttgaaaaa gaggctacaa gcgccgaaac agaccaagaa ggtgtaagag tatggaagca 87001 gaaatctggg gtagacgaat tcgtgcattc agaaagctga aaggttatac tcaagaagga 87061 tttgcaaaag cattaggtat atcagtttct attctcggcg aaattgaacg cggaaaccga 87121 ttgccgtctg ctgccatcat tcaagatgca gcagatgttt taaatataag tgcggacgaa 87181 ttggcgccgc cagaaaaata gaacaaatga aaggaggaga aaaattgttc aaaatcggag 87241 atattcaatt gaaaaaccgg gttgtgctcg cacctatggc tggtgtctgc aactctgcgt 87301 tcagattgac tgtaaaggaa ttcggagccg gattggtatg cgctgaaatg gtcagtgaca 87361 aagcgatcct ttacaacaat gcaagaacaa tgggtatgct ttatattgat gaacgtgaga 87421 aaccactgag ccttcaaatt ttcggaggaa aaaaggaaac ccttgtggaa gcggcgaagt 87481 ttgtagacca aaacacaact gctgatatca ttgatattaa catgggatgt cccgtgccga 87541 agattacaaa atgcgatgcg ggagccaaat ggcttctcga tcctgataag atttacgaaa 87601 tggtttctgc agtagtggat gctgttaata agccagttac agtgaaaatg agaatgggct 87661 gggatgaaga ccacattttc gcagtgaaaa atgcacaggc tgtagaacgt gcgggcggta 87721 aagcagtggc gcttcacggc cgtacgagag tgcagatgta cgaaggaacg gcaaactggg 87781 atatcatcaa agaagtaaaa caatcagtat cgattccggt tatcggaaac ggcgatgtta 87841 agacaccgca ggatgctaag cgtatgctcg atgagacagg agtagacggg gtcatgatcg 87901 gacgcgctgc attgggtaac ccgtggatga tttaccgtac ggttcagtat cttgaaacag 87961 gtaaattaaa agaagagccg caagtacgcg aaaaaatggc cgtatgcaaa ctgcatcttg 88021 accgcctgat tgacttaaaa ggtgaaaacg tagcggtaag agaaatgaga aagcacgctg 88081 catggtatct gaaaggcgtg aaaggcaatg cgaacgttcg taatgaaatc aatcattgcg 88141 agacgagaga agagtttgta cagcttttag atgcatttac ggttgaagtt gaggcaaaag 88201 agcttcaaaa tgcaaaagta ggataatact cacctctatt tgctgctcac tgctagtttt 88261 acgctggcag tttttctgct tttttcatga aacaatatct gtaatggagt gataacaatg 88321 agtcaagaag agcataacca tgaagaattg aatgatcagc tgcaagtcag acgcgataaa 88381 atgaatcagc tgagagataa cggcatcgat ccattcggcg cacgttttga aagaactcat 88441 cagtctcaag aagttatttc ggcatatcaa gatctaacca aagaagagtt agaagaaaaa 88501 gcgattgaag ttacaatcgc aggccgcatg atgacaaaac gcggcaaagg aaaagccggc 88561 tttgcccatc ttcaggattt agaaggccaa atccaaatct acgtaagaaa agacagtgtc 88621 ggtgacgacc aatatgaaat cttcaagtct tctgacctcg gtgatcttat cggcgtaacc 88681 ggaaaagtct tcaaaacaaa tgtaggcgaa ttgtctgtta aagcaacttc ctttgaattg 88741 ctgacaaaag cgcttcgtcc gcttcctgac aaataccatg gtttaaaaga cgttgagcag 88801 cgctaccgtc agcgctatct ggatcttatc gtaaacccag acagcaaaca tacgttcatt 88861 acacgaagca agatcattca agctatgaga aggtaccttg atgatcatgg atacttagaa 88921 gtagaaacac ctacaatgca cagcattcct gggggagctt ctgcacgtcc gtttatcact 88981 caccacaacg cgttagacat tccactctat atgcgtattg ctatcgaact gcacctaaaa 89041 cgtctaattg tcggcggttt agaaaaagta tatgaaatcg gccgtgtttt ccgtaacgaa 89101 ggtgtctcta cacgccataa ccctgaattt acaatgattg agttatatga agcatatgcg 89161 gactataaag atatcatgag cttaactgaa aaccttgtcg ctcatatcgc ccaagaagtg 89221 cttggcacaa ctacgattca atacggggaa gagcaaatcg accttaaacc ggagtggaaa 89281 agaatccata tggttgacgc agtcaaagaa gcgaccggcg ttgatttctg ggaagaggtt 89341 actgttgagc aggcgcgtga atatgcaaaa gaacatgaag tagaaattaa agactctatg 89401 acagtaggcc atatcatcaa cgaattcttc gaacaaaaaa ttgaagaaac gcttattcag 89461 ccaacgttta tttacgggca tcctgtagaa atttctcctc ttgctaagaa aaaccctgag 89521 gacccgcgtt ttacagaccg ttttgagctg tttatcgttg gccgtgaaca tgccaacgcg 89581 tttacagagc tgaatgatcc tattgatcaa agagaacgct ttgaagcgca attaaaagag 89641 cgtgaagccg gtaatgatga agctcattta atggatgaag actttgttga agctctggaa 89701 tacggtatgc cgccaacagg aggtttaggc atcggtatcg accgtctggt tatgctgctg 89761 acgaatgccc cttctattcg cgatgtgctg ttattcccgc aaatgagaca acgctaataa 89821 aaaagagcgg tatcctccat agggaaagga tgccgctctt tttaaatccc ttagtatttc 89881 ttcaaaaaaa ctattgcact attatttact aggtggtata ttattattcg ttgccgctaa 89941 acaaggcgat aacgaaaaaa agaacttcaa aaaaagttat tgacttcact gagtcaacga 90001 gttataataa taaagtcgct tgaacgaagt gaacaaaatg atctttgaaa actaaacaag 90061 acaaaacgta cctgttaatt cagtttttaa aaatcgcaca gcgatgtgcg tagtcagtca 90121 aactacttta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc gtgcctaata 90181 catgcaagtc gagcggacag atgggagctt gctccctgat gttagcggcg gacgggtgag 90241 taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg ggctaatacc 90301 ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta ccacttgcag 90361 atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc aacgatgcgt 90421 agccgacctg agagggtgat cggccacact gggactgaga cacggcccag actcctacgg 90481 gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa cgccgcgtga 90541 gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt gccgttcgaa 90601 tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt gccagcagcc 90661 gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg gctcgcaggc 90721 ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat tggaaactgg 90781 ggaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa tgcgtagaga 90841 tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc tgaggagcga 90901 aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa cgatgagtgc 90961 taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc actccgcctg 91021 gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca caagcggtgg 91081 agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac atcctctgac 91141 aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca tggttgtcgt 91201 cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgatcttagt 91261 tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga ggaaggtggg 91321 gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta caatggacag 91381 aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc tcagttcgga 91441 tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg atcagcatgc 91501 cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga gagtttgtaa 91561 cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg acagatgatt 91621 ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac ctcctttcta 91681 aggatatttt acggaatata agaccttggg tcttataaac agaacgttcc ctgtcttgtt 91741 tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa cagtagacat 91801 cacattcaag taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg 91861 gcgcacggtg gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc 91921 ttcggggagc tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc 91981 gtaatggagt ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact 92041 gaaacatcta agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc 92101 gaaacgggat tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg 92161 gagttacaaa ggaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca 92221 gccctgtagt caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga 92281 aattccgtcg gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata 92341 gtgaaccagt accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc 92401 tgaaaccgtg tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta 92461 gaatgaaccg gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg 92521 aaagcgagtc tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta 92581 cccatgtcca gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga 92641 aaagtgcggg gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg 92701 ttctctccga aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg 92761 attggactag gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact 92821 tatccttggg agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga 92881 ccgccagcta aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca 92941 accaggatgt tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg 93001 agtgactctg cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc 93061 ttcgaacagt ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg 93121 agcgcttaga agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac 93181 cgaatgccta aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc 93241 gaggccgaaa ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca 93301 tttgagcaat ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca 93361 agcagttagg ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag 93421 cgaaatatag tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga 93481 gaggtgcccg taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag 93541 agaactctcg ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct 93601 gttagggtgc aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa 93661 cacaggtctc tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga 93721 aggttaagag gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg 93781 ccgtaactat aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac 93841 gaaaggcgca acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg 93901 tgaagatgca ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg 93961 atattgaatg ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca 94021 gcttcggtgg aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc 94081 ccttatcggg cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa 94141 aaggtaacgg aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta 94201 aaggcacaag ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt 94261 agtgatccgg tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg 94321 ataacaggct tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc 94381 ggctcatcgc atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag 94441 cggtacgcga gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg 94501 caggaaattt gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt 94561 gtaccagttg ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg 94621 aaagcatcta agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag 94681 atccctgaaa gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct 94741 gacagatact aatcgatcga ggacttaacc atatttttga atgatgtcac atctgttatc 94801 tagttttgag agaacactct caatttgttt ggtggcgata gcgaagaggt cacacccgtt 94861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 94921 gtgagagtag gacgccgcca agcaattgca cgttagtgca attatggagg attagctcag 94981 ctgggagagc atctgcctta caagcagagg gtcggcggtt cgagcccgtc atcctccacc 95041 attatgccgg tgtagctcaa ttggtagagc aactgacttg taatcagtag gttgggggtt 95101 caagtcctct tgccggcacc acttttatat gatataatac tcaagtctct tgtagaagag 95161 ccattagctc agttggtaga gcatctgact tttaatcaga gggtcgaagg ttcgagtcct 95221 tcatggctca ccattttacg cgggtgtggc ggaattggca gacgcgctag acttaggatc 95281 tagtgtcttt atgacgtggg ggttcaagtc ccttcacccg cattatatag gataacagtt 95341 agaaaaactg gacatcctgt ctgcggaagt agttcagtgg tagaacacca ccttgccaag 95401 gtgggggtcg cgggttcgaa tcccgtcttc cgctccaact ataccatcca cgccggggtg 95461 gtggaattgg cagacacaca ggacttaaaa tcctgcggta ggtgactacc gtgccggttc 95521 aagtccggcc ctcggcatta tgttttgcgc ccgtagctca attggataga gcgtttgact 95581 acggatcaaa aggttagggg ttcgactcct ctcgggcgcg ccatatcttt taatagaata 95641 gataggaaat cgggaagtag ctcagcttgg tagagcacat ggtttgggac catggggtcg 95701 caggttcgaa tcctgtcttc ccgaccattt ttttatgggg ccttagctca gctgggagag 95761 cgcctgcttt gcacgcagga ggtcagcggt tcgatcccgc taggctccac caaaagtttt 95821 taaaaaagtt gttgactttg aagaagtgac gttgtatact aataaagttg ctttaacaaa 95881 gcggacaaac aaaatgatct ttgaaaacta aacaagacaa aacgtacctg ttaattcagt 95941 ttttaaaaat cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat 96001 cctggctcag gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg 96061 gagcttgctc cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta 96121 agactgggat aactccggga aaccggggct aataccggat ggttgtttga accgcatggt 96181 tcaaacataa aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag 96241 ttggtgaggt aacggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc 96301 cacactggga ctgagacacg gcccagactc ctacgggagg cagcagtagg gaatcttccg 96361 caatggacga aagtctgacg gagcaacgcc gcgtgagtga tgaaggtttt cggatcgtaa 96421 agctctgttg ttagggaaga acaagtaccg ttcgaatagg gcggtacctt gacggtacct 96481 aaccagaaag ccacggctaa ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg 96541 ttgtccggaa ttattgggcg taaagggctc gcaggcggtt tcttaagtct gatgtgaaag 96601 cccccggctc aaccggggag ggtcattgga aactggggaa cttgagtgca gaagaggaga 96661 gtggaattcc acgtgtagcg gtgaaatgcg tagagatgtg gaggaacacc agtggcgaag 96721 gcgactctct ggtctgtaac tgacgctgag gagcgaaagc gtggggagcg aacaggatta 96781 gataccctgg tagtccacgc cgtaaacgat gagtgctaag tgttaggggg tttccgcccc 96841 ttagtgctgc agctaacgca ttaagcactc cgcctgggga gtacggtcgc aagactgaaa 96901 ctcaaaggaa ttgacggggg cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 96961 cgcgaagaac cttaccaggt cttgacatcc tctgacaatc ctagagatag gacgtcccct 97021 tcgggggcag agtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 97081 ttaagtcccg caacgagcgc aacccttgat cttagttgcc agcattcagt tgggcactct 97141 aaggtgactg ccggtgacaa accggaggaa ggtggggatg acgtcaaatc atcatgcccc 97201 ttatgacctg ggctacacac gtgctacaat ggacagaaca aagggcagcg aaaccgcgag 97261 gttaagccaa tcccacaaat ctgttctcag ttcggatcgc agtctgcaac tcgactgcgt 97321 gaagctggaa tcgctagtaa tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct 97381 tgtacacacc gcccgtcaca ccacgagagt ttgtaacacc cgaagtcggt gaggtaacct 97441 tttaggagcc agccgccgaa ggtgggacag atgattgggg tgaagtcgta acaaggtagc 97501 cgtatcggaa ggtgcggctg gatcacctcc tttctaagga tattttacgg aatataagac 97561 cttgggtctt ataaacagaa cgttccctgt cttgtttagt tttgaaggat cattccttcg 97621 aaacgtgttc tttgaaaact agataacagt agacatcaca ttcaagtaat acaagatatc 97681 acatagtgat tctttttaac ggttaagtta gaaagggcgc acggtggatg ccttggcact 97741 aggagccgat gaaggacggg acgaacaccg atatgcttcg gggagctgta agcaagcttt 97801 gatccggaga tttccgaatg gggaaaccca ccactcgtaa tggagtggta tccatatctg 97861 aattcatagg atatgagaag gcagacccgg ggaactgaaa catctaagta cccggaggaa 97921 gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa cgggatcagc ccaaaccaag 97981 aggcttgcct cttggggttg taggacactc tgtacggagt tacaaaggaa cgaggtagat 98041 gaagaggtct ggaaaggccc gccataggag gtaacagccc tgtagtcaaa acttcgttct 98101 ctcctgagtg gatcctgagt acggcggaac acgtgaaatt ccgtcggaat ccgggaggac 98161 catctcccaa ggctaaatac tccctagtga ccgatagtga accagtaccg tgagggaaag 98221 gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa accgtgtgcc tacaagtagt 98281 cagagcccgt taacgggtga tggcgtgcct tttgtagaat gaaccggcga gttacgatcc 98341 cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag cgagtctgaa tagggcgcat 98401 gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca tgtccagggt gaagttcagg 98461 taacactgaa tggaggcccg aacccacgca cgttgaaaag tgcggggatg aggtgtgggt 98521 aggggtgaaa tgccaatcga acctggagat agctggttct ctccgaaata gctttagggc 98581 tagcctcaag gtaagagtct tggaggtaga gcactgattg gactaggggc ccctaccggg 98641 ttaccgaatt cagtcaaact ccgaatgcca atgacttatc cttgggagtc agactgcgag 98701 tgataagatc cgtagtcgaa agggaaacag cccagaccgc cagctaaggt cccaaagtat 98761 acgttaagtg gaaaaggatg tggagttgct tagacaacca ggatgttggc ttagaagcag 98821 ccaccattta aagagtgcgt aatagctcac tggtcgagtg actctgcgcc gaaaatgtac 98881 cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg aacagtggta ggagagcgtt 98941 ctaagggctg tgaagccaga ccggaaggac tggtggagcg cttagaagtg agaatgccgg 99001 tatgagtagc gaaagagggg tgagaatccc ctccaccgaa tgcctaaggt ttcctgagga 99061 aggctcgtcc gctcagggtt agtcgggacc taagccgagg ccgaaaggcg taggcgatgg 99121 acaacaggtt gatattcctg taccacctcc tcaccatttg agcaatgggg ggacgcagga 99181 ggatagggta agcgcggtat tggatatccg cgtccaagca gttaggctgg gaaataggca 99241 aatccgtttc ccataaggct gagctgtgat ggcgagcgaa atatagtagc gaagttcctg 99301 attccacact gccaagaaaa gcctctagcg aggtgagagg tgcccgtacc gcaaaccgac 99361 acaggtaggc gaggagagaa tcctaaggtg atcgagagaa ctctcgttaa ggaactcggc 99421 aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta gggtgcaagc ccgagagagc 99481 cgcagtgaat aggcccaggc gactgtttag caaaaacaca ggtctctgcg aagccgtaag 99541 gcgaagtata ggggctgacg cctgcccggt gctggaaggt taagaggagc gcttagcgta 99601 agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt aactataacg gtcctaaggt 99661 agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa ggcgcaacga tctgggcact 99721 gtctcaacga gagactcggt gaaattatag tacctgtgaa gatgcaggtt acccgcgaca 99781 ggacggaaag accccgtgga gctttactgc agcctgatat tgaatgttgg tacagcttgt 99841 acaggatagg taggagcctt ggaaaccgga gcgccagctt tggtggaggc atcggtggga 99901 tactaccctg gctgtattga ccttctaacc cgccgccctt atcgggcggg gagacagtgt 99961 caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg taacggaggc gcccaaaggt 100021 tccctcagaa tggttggaaa tcattcgcag agtgtaaagg cacaagggag cttgactgcg 100081 agacctacaa gtcgagcagg gacgaaagtc gggcttagtg atccggtggt tccgcatgga 100141 agggccatcg ctcaacggat aaaagctacc ccggggataa caggcttatc tcccccaaga 100201 gtccacatcg acggggaggt ttggcacctc gatgtcggct catcgcatcc tggggctgta 100261 gtcggtccca agggttgggc tgttcgccca ttaaagcggt acgcgagctg ggttcagaac 100321 gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg aaatttgaga ggagctgtcc 100381 ttagtacgag aggaccggga tggacgcacc gctggtgtac cagttgttct gccaagggca 100441 tcgctgggta gctatgtgcg gacgggataa gtgctgaaag catctaagca tgaagccccc 100501 ctcaagatga gatttcccat tccgcaagga agtaagatcc ctgaaagatg atcaggttga 100561 taggtctgag gtggaagtgt ggcgacacat ggagctgaca gatactaatc gatcgaggac 100621 ttaaccatat ttttgaatga tgtcacatct gttatctagt tttgagagaa cactctcaat 100681 ttgtttggtg gcgatagcga agaggtcaca cccgttccca taccgaacac ggaagttaag 100741 ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggacg ccgccaagca 100801 agcttaaacc cagctcaatg agctgggttt tttgtatttt ggtttattgg tatcataaaa 100861 ttccacttaa ctgtataata taataacttt ataccgaatt ttaaatcagc aatcaggttt 100921 tgtggaccgg gaaaatggaa ataatgaagg atagagcgag aaagttgaaa attctcgaga 100981 aacggcttat agtaagatta aagtcaaata tagtcaaagt cagtaaagga gggggttgag 101041 tgggacataa tatttctgac atcattgaac aatatttaaa acgagtgtta gatcaaaatg 101101 gcaaggaaat tttagagatt aaacgaagtg aaattgcaga taaatttcaa tgcgttcctt 101161 cccaaataaa ttatgtcatc aacaccagat ttacaagcga aagaggatat attgttgaga 101221 gcaaacgcgg gggcggcggt tacatcagaa tcattaaaat taaaatgaac aatgaagttg 101281 tcctgatcaa taatataatt tctcaaatta atacccattt gtctcaagca gcctctgatg 101341 acattatttt aaggctatta gaagacaagg taatttcaga aagagaagca aaaatgatgg 101401 tcagcgtaat ggaccgctca gttttacaca ttgacttacc tgaacgtgat gaattaagag 101461 cgagaatgat gaaggcaatg ctgacttctt taaaattaaa ataagcgggt gaaaagattg 101521 atttgtcaag agtgccacga gagaccagcc acttttcact ttacaaaggt tgttaacgga 101581 gaaaaaatag aagttcatat ttgtgaacaa tgtgccaaag aaaatagtga ttcatatggt 101641 ataagtgcaa atcagggttt ctctattcat aatttacttt cgggtttact gaacatggat 101701 tcttcatttc aaaatgcagg aactcaaatg ttcagtcact cggagcaaat atctgcttgt 101761 ccgaaatgcg gaatgacttt tcagcaattc agaaaaattg gccgttttgg atgttctgaa 101821 tgttacaaaa catttcatag caacattaca ccaatcctac gtaaagtgca cagcggaaac 101881 actgtgcatg caggtaagat accgaaacga ataggcggca atcttcatgt cagacggcag 101941 attgatatgc taaaaaagga attagaatcc ttaatccatc aagaagaatt tgaaaatgca 102001 gctcatgtaa gagatcaaat tcgtttatta gaacaatcac tcaaaagtac agatagtgag 102061 gaggaacagg agtaatgtcg ctaaagcatt ttattcagga cgcactaagc agttggatga 102121 agcagaaagg acctgaaagt gacattgtac tcagcagccg catacgttta gcaagaaact 102181 ttgagcatat tcggttccct acgcggtatt ccaatgaaga agcctcatcc atcatacagc 102241 aatttgaaga tcagttttca gagcaagaaa ttcccggaat cggcaaattt gttttgatta 102301 gaatgaatga tgcacagcct ttagaaaagc gtgtacttgt tgaaaaacat ctaatcagcc 102361 cgaatttgac agagtctcct tttggcggct gtttgctttc tgaaaatgag gaagtaagcg 102421 tcatgctaaa tgaagaggac catattagaa ttcagtgtct tttccctgga tttcagcttt 102481 tagaagcaat gaaagccgca aaccaggtcg acgactggat tgaagaaaaa gttgattatg 102541 cattcaatga gcaaagagga tacttaacca gctgtcctac aaacgtaggt actggtttaa 102601 gggcttcggt catgatgcat ctgccggcgc tggttttaac taggcaaata aatcgaatta 102661 taccggcaat taatcaatta ggcttagttg ttagaggaat ttatggggaa ggcagcgaag 102721 cagtagggaa tatctttcaa atttcaaatc agatcacgct tggtaagtca gagcaggata 102781 ttgtagagga tcttaacagt gttgctgctc agttgattga acaagaacga tctgcccgag 102841 aagcgattta tcaaacttct aaaatcgaac ttgaggatcg ggtatatcgg tcatatgggg 102901 tcttgtctaa ttgccggatg atagaatcga aagaaactgc aaagtgcctt tcagatgttc 102961 ggttaggcat agacttaggc ataataaaag gactttcaag caacatactt aacgaactta 103021 tgattttgac gcagccaggg tttttacagc aatactcggg aggcgctttg cgaccgaacg 103081 aaagggacat tcgaagagcg gctctcatca gagaacggct tcacttagaa atgaatggga 103141 aaagacagga ggatgaatcg atatgatgtt tggaagattt acagaacgag ctcaaaaagt 103201 actggcgcta gcacaggaag aagcacttcg gttaggtcat aataacattg gcactgagca 103261 tattttatta ggactggtaa gagaaggaga gggcattgct gctaaagctc ttcaagcgct 103321 tggactcggt tcagaaaaaa ttcagaaaga agtagaaagt ttgatcgggc gcgggcagga 103381 aatgtctcaa acgattcatt atactcctag agctaaaaaa gtcattgagc tttcaatgga 103441 tgaggcaaga aaactcggtc attcttatgt gggaacagaa catattcttc ttggtctgat 103501 tcgtgaagga gaaggtgttg ctgcgagagt tctgaataat ctcggtgtca gcttaaataa 103561 agcaagacag caggtgctcc agcttctagg aagtaatgaa acaggatcat cagcggcagg 103621 aacaaacagc aatgcgaata cgcctacgct tgacagcttg gcaagagact taactgctat 103681 tgcgaaggaa gacagccttg accctgtaat cggcagaagc aaggagatcc agcgtgtcat 103741 tgaagtgtta agccgcagaa cgaaaaacaa ccctgttctc attggggaac caggtgtagg 103801 taaaacggct atcgcagaag gtttggcaca gcaaattatc aataatgaag tacccgaaat 103861 tttgcgtgat aaacgtgtga tgacattaga catgggaaca gttgttgccg gcacaaaata 103921 ccgcggagaa tttgaggatc gcctgaagaa ggtcatggat gaaattcgcc aggcaggaaa 103981 tatcattcta ttcatcgatg agctccatac attaatcggg gcaggcggag cagaaggtgc 104041 tattgatgca tctaatattt taaaaccttc acttgctcgt ggcgaactcc aatgtattgg 104101 tgcaacgact cttgatgagt accgtaaata tattgaaaaa gatgcagcac tggaacgccg 104161 ttttcagccg attcaggttg atcagccatc tgtagatgaa agtattcaaa ttttacaagg 104221 tctgcgtgac agatacgaag cccaccaccg cgtttctatc actgatgatg ccattgaagc 104281 tgcggttaag ctttctgaca gatatatttc tgaccgcttc cttccggata aagcaattga 104341 cttgatcgat gaagcgggtt caaaggtgag actgcgctca tttacaacgc ctcctaactt 104401 aaaagagctt gagcagaagc ttgatgaggt tcgtaaagag aaggatgcgg cagtgcaaag 104461 ccaagagttt gaaaaagctg cttccttgcg tgatactgaa caacgcctgc gcgagcaagt 104521 agaggatacg aagaaatcat ggaaagagaa gcaagggcag gaaaactcag aggttactgt 104581 ggatgatatt gcgatggttg tatccagctg gaccggtgtg cctgtatcta aaatcgccca 104641 aactgaaact gataagcttc tcaatatgga aaacattctt cactcccgtg tcatcggcca 104701 ggatgaagca gttgtagcgg ttgcaaaagc cgtcagacgt gcaagagcag gattgaaaga 104761 tcctaaacgc ccaatcggct cattcatttt cttaggccct acaggtgtag gtaaaacaga 104821 acttgcacga gcacttgctg aatccatttt tggcgatgaa gaatccatga tcagaattga 104881 tatgtctgaa tacatggaaa aacattcaac ttcaagactt gttggttcac ctccgggtta 104941 tgtgggatat gatgaaggcg gtcaattgac agagaaagtc agaagaaaac cttactctgt 105001 cgtgcttctt gatgagatcg agaaagcgca ccctgatgtc ttcaatatcc ttctgcaagt 105061 tcttgaagac ggacgattga ctgattctaa aggacgcaca gtcgatttcc gcaataccat 105121 tctgatcatg acatcaaacg tcggagcaag tgagctaaaa cgcaataaat atgtcggctt 105181 taacgttcag gatgaaactc aaaatcataa agacatgaaa gataaagtga tgggtgaatt 105241 aaaacgagcg ttcagacctg agttcatcaa ccgtattgat gaaatcattg tcttccattc 105301 acttgagaaa aaacatctca ctgagattgt gtcattaatg tctgatcaat taacgaaacg 105361 cctgaaagaa caagatcttt ctatcgaatt gacagatgct gcaaaagcga aagtcgcgga 105421 agagggcgtt gacctggaat acggtgcccg tccgttaaga agagcgatcc aaaaacatgt 105481 cgaggatcgt ttatctgaag aactcctcag aggaaatatt cataaaggac agcatattgt 105541 tcttgatgta gaagatggcg aatttgtcgt aaaaacgact gctaaaacga attaatatag 105601 aagacggaaa tgaggcatac agcatgtaag tgtatgcctc actttcatat caagaaatag 105661 aacaagggag aggtcttaca ctatatatgg ctaaaacaaa atcgaagttc atctgccaat 105721 cctgcggcta cgagtctcca aaatggatgg ggaaatgtcc gggctgtggt gcttggaata 105781 caatggtgga agaaatgatt aaaaaagcac cggccaatcg gagagcggct ttttctcatt 105841 ctgttcaaac tgtacagaaa ccttcaccta ttacatcaat cgaaacatca gaagaacccc 105901 gcgtcaaaac ccagcttggc gagtttaaca gagtactcgg cggaggtgtc gttaaaggct 105961 ccctcgtttt aattggcggt gatcctggta tcggaaagtc aacgctatta ctgcaggttt 106021 ccgctcaatt atcaggctca tcaaacagtg tcctgtatat ttcgggagaa gaatctgtaa 106081 agcaaacgaa gctgcgagca gaccgtctcg gcattaataa tccgtcactg catgttttat 106141 ctgaaaccga tatggagtat atttcgtctg ctatacaaga gatgaatcca tcgtttgtcg 106201 ttgttgactc tattcaaacg gtttaccaaa gcgatattac atctgctcca ggcagtgtgt 106261 cacaggtcag agaatgtacc gctgagctga tgaaaattgc aaaaacaaaa ggtattccga 106321 tttttatcgt agggcacgtg acgaaagaag ggtctattgc aggtccgaga ctgttggagc 106381 atatggttga cactgtttta tattttgaag gagaacgcca ccatactttc cgtattttgc 106441 gggctgtaaa aaaccgtttc ggatctacaa acgaaatggg cattttcgaa atgcgggaag 106501 aggggctcac tgaggttttg aatccttcgg aaattttctt agaagaacgc tctgctggtt 106561 ccgcaggctc gagtatcact gcctctatgg agggcactag accgattctc gttgaaattc 106621 aggcactcat ctcgccaaca agttttggca acccaaggcg tatggcaacg ggaatagacc 106681 ataacagggt ttctctgtta atggctgtgt tagaaaaaag agttggactg ctgctgcaaa 106741 atcaggatgc ttatttgaaa gtggctggcg gcgttaagct tgatgaaccg gcaattgatc 106801 ttgcgattgt gattagtatt gcatcaagct ttagagacac acctccaaat cctgcagatt 106861 gttttattgg agaagtggga ttaaccggag aagtccggcg ggtttcaaga attgaacagc 106921 gtgtgaaaga agcggcaaag cttggtttta aacgcatgat catacccgcg gcaaatctgg 106981 atggatggac aaaaccaaaa gggattgagg ttatcggagt agcaaatgtt gcagaagcgc 107041 ttcgtacttc attaggagga taatagatgg aaaaagagaa aaaaggggcg aaacacgagt 107101 tagacctgtc atctatattg cagtttgttg ctccgggtac accgctcaga gcggggatgg 107161 aaaacgtctt gagagcaaat acaggcggtc tgattgttgt tggatataat gataaagtaa 107221 aagaagtggt ggacggcggc tttcacataa acacggcttt ttctccggcg catttatatg 107281 agctggctaa aatggatgga gcgatcattt taagtgattc tggtcaaaag atcctatacg 107341 cgaatactca gctgatgccg gatgccacaa tttcttcatc agaaacagga atgcggcaca 107401 gaactgccga aagagtagct aagcaaactg gctgtcttgt aatcgccatt tctgaaagaa 107461 gaaatgtcat aacgttatat caggaaaaca tgaagtatac actaaaagac ataggattta 107521 ttttaaccaa ggcgaaccaa gccattcaaa cacttgaaaa atataagaca atcctcgata 107581 aaacgattaa tgcactgaac gcgttagagt ttgaggaact tgttaccttc agtgatgtct 107641 tgtctgtcat gcatcgttat gaaatggtac tgagaatcaa aaacgaaatt aatatgtata 107701 tcaaagagct ggggacagaa gggcatctga tcaaactgca agtcattgaa ttgattacgg 107761 atatggaaga agaggccgct ttatttatta aggactatgt aaaagaaaag attaaagatc 107821 cgtttgttct cttgaaggag ctgcaggata tgtccagtta tgatctgctg gatgattcca 107881 ttgtgtataa gcttctcggt taccctgctt ctactaatct tgatgattat gtattgccga 107941 gaggatacag gctgttaaat aagataccgc gtcttccgat gccgattgtt gaaaatgttg 108001 tagaagcatt tggagtcctg ccaaggatta ttgaggcgag tgcagaagaa ttagatgaag 108061 tagagggaat cggtgaagta cgagcccaaa aaatcaaaaa aggattaaaa cgcctgcaag 108121 agaagcatta tttagacaga caactgtgat ttcggttaaa accttatgaa tacgggtata 108181 ttaatgttgg tttttgttta ttctgatatt cgtaggatgc ataagacttt gtgaaattaa 108241 aatgttaaaa aaggaggtgg gggtatgtta aaacgaatag ttcaggcgtt cttcattatt 108301 tttggcggcg ttgttggtat atttttgata cctgaattgt ttgtactgtt aaatatacag 108361 gacatacctt taataacaaa cgcatatacg tctgcggcaa taggagcaat tatctttttt 108421 ctcatcagta tatggggtac agaatacgtt gtgaactggg tgaagtggat agaggattca 108481 ttgttaaaag cgccggttcc agatttgtta tttggaagtc ttggcttagt ttttggactt 108541 ataattgctt atcttatcgt aaatgttatt cctttagaca atatacctta ccgcatattc 108601 agcacaataa ttcctgtatt tttggctttc ttcctcggtt atctcggctt ccaggtgggc 108661 tttaagaaaa aggatgaatt gatcagcctg ttttccattt ccgccagaat gcaaaagaaa 108721 aaaggaacag ctgatgaaga acatgaggtt caagacaaga agctgaaaat tttggacact 108781 agtgttatta ttgatgggag aatagcagat atttgtcaga ctggtttttt agagggagtt 108841 atcgtgattc cgcagtttgt ccttgaggaa ttgcagcata ttgcagactc ttcagatgtt 108901 ttaaaacgaa acagaggacg ccgcggtctt gatatcctga accgcattca gaaagaatta 108961 gacattgaag ttgaaattta cgaaggcgac tttgaagata ttcaggaggt tgacagcaag 109021 ctcgtcaaac ttgctaagct gacatccggg gtcgttgtga cgaatgattt taatttaaat 109081 aaagtgtgcg agcttcagaa ggtagcagta ttaaacatta atgaccttgc caatgcggtt 109141 aagcctgttg tgcttcctgg cgaggaaatg aatgttcagg tcattaagga cgggaaagag 109201 cataatcagg gagttgccta cttggatgac ggtacgatga ttgtcgttga agaaggacgg 109261 aattatatcg gcaagcatat tgatgtactc gtcacaagtg tgctgcagac agcagcggga 109321 cgaatgattt ttgcgaagcc taagctgttg gagaaggcgc tgtaaaggga gaagaaacaa 109381 tgagttatga tgtggtgatt cctgcagccg gacagggaaa gcggatgaag gcagggagaa 109441 ataaactgtt cattgagctg aagggagacc cggtgatcat acacacgtta agagtgtttg 109501 acagccaccg gcagtgcgat aaaatcattt tggtgattaa cgagcaggag cgggagcact 109561 ttcagcaatt gctgtccgat tacccgtttc aaacttcaat tgagcttgtt gcaggcggag 109621 atgagcgaca gcacagtgtg tataaggggc tgaaagccgt aaagcaggaa aagattgtcc 109681 ttgtacatga cggtgcccgt ccatttataa aacatgaaca aattgacgaa ctgatcgcag 109741 aggcggaaca gacaggagcg gccatccttg ctgttccggt aaaagatacg attaaacgcg 109801 ttcaagattt acaagtcagt gagacgattg aacgttcaag cttgtgggct gtccaaacgc 109861 cacaagcttt tcgtctttct ttattgatga aggctcacgc tgaggccgag cgcaagggat 109921 ttttagggac ggatgacgcc agcctcgttg aacagatgga gggcggttcg gtccgtgttg 109981 tagaaggcag ctatacaaat attaagctga cgacgccaga cgatttgacg tcagctgaag 110041 ctatcatgga atcagaaagt gggaataaac atgtttagaa ttggacaagg atttgatgtg 110101 catcaattag tggagggccg tcctctcatt attggcggaa ttgaaatccc gtacgaaaaa 110161 gggctgcttg gccattctga tgcagacgta ttgttgcata ccgtcgctga cgcctgcctg 110221 ggagctgtgg gtgaaggaga cataggcaag cattttcctg acacagatcc cgagttcaag 110281 gacgcagatt ctttcaaatt acttcagcat gtctggggaa tcgtgaaaca gaaggggtat 110341 gtccttggga acattgattg caccatcata gcgcaaaagc cgaagatgct gccgtacata 110401 gaagatatga gaaaaagaat tgctgaaggc cttgaggcag atgtttctca agtaaatgta 110461 aaagcaacaa cgacagaaaa gcttggattt acaggccggg cggaaggaat agcggctcag 110521 gcgacagtac tgatacaaaa aggctaactt gttttgatgc cgggtctatt tggtggtaga 110581 atagattcat acatttttgc ctgaggccat acatgacatg aaaggaagta tttgaaaatg 110641 ggaaacgaag tacgcgtccg ttatgcaccg agtccaaccg gacatttgca tattggaaat 110701 gccagaacgg cgctttttaa ttatttattt gcccgcaatc aaggcggtaa gtttatcatt 110761 cgagttgagg atactgataa aaagcgcaat attgagggcg gagaacaaag ccagctgaat 110821 tatctgaagt ggctaggtat tgactgggat gagagtgtgg atgtcggagg agagtacggt 110881 ccataccgtc agtcagagcg taacgatatc tataaagtgt actatgaaga gcttcttgaa 110941 aaagggcttg cttataaatg ttactgtacg gaagaagagc ttgaaaaaga gcgtgaagaa 111001 cagattgccc gcggagaaat gcctcgttat tccggaaaac acagagacct gactcaggaa 111061 gaacaggaga aatttatcgc cgaaggcaga aaaccaagta ttcgtttccg tgtgccggaa 111121 ggaaaagtca tcgccttcaa cgacatcgta aaaggcgaaa tttcttttga atcagatggc 111181 atcggcgact tcgttattgt gaaaaaggac ggaacgccta cttataactt cgcggtagct 111241 attgatgact acttaatgaa aatgacacac gtgctgcgcg gtgaggatca tatttctaac 111301 acaccgaaac agattatgat ctatcaagca ttcgggtggg atattcctca gttcggacac 111361 atgacgctga ttgtaaacga aagccgtaaa aagctcagca aacgtgatga atccattatt 111421 caattcatcg agcagtacaa agagcttggc tacctgccag aagcgctgtt caactttatc 111481 ggcttgttag gctggtcacc ggttggagaa gaagagcttt tcacaaaaga gcagtttatt 111541 gaaatttttg atgtaaatcg tttatctaaa tcaccagctt tgtttgatat gcataagcta 111601 aaatgggtta acaaccaata tgtgaagaag ctggatcttg atcaggttgt tgaactgacg 111661 cttccgcatt tgcaaaaagc cggcaaagtt ggcactgagc tttctgctga agaacaagaa 111721 tgggttcgta aactgatttc cctgtatcat gagcaattaa gctacggtgc ggaaattgtt 111781 gagctgactg atttgttctt tacggatgag atcgagtata atcaagaagc gaaagctgtt 111841 ctggaagaag aacaggttcc tgaagtgctc agcacattcg cagcgaagct tgaagagctt 111901 gaggagttca ctccggataa tatcaaagca tcgatcaaag cagtgcagaa agaaactggc 111961 cataaaggga aaaaactgtt tatgccgatt cgtgttgctg taacagggca aactcacggt 112021 ccggaactgc cgcaatcaat tgaattgatc ggtaaagaga ctgcaattca gcgtttaaag 112081 aatatctaaa taaatgattg ttgacaggga agagtataaa gctttaggcc attacagaaa 112141 ggatcttcat tggctgagag agatccatga gccgggtttt agaagtgcgc ccttaagacc 112201 tttgaagaac gttttttgaa atcagtattc aaaggcggcc gccgccgtta caggctgaag 112261 ttgggagagc agaagtctgc ttttcaaaca gagtggaacc gcgcggttaa agcgtctctg 112321 tcatgtttac atgcagagac gcttttttta ttgggtagag gaaatcagat agagaaacgg 112381 ggggaagcat gtgtttttta gaatgctcaa agaagacatt gatactgtgt tcgatcaaga 112441 tcccgcagca agaagctatt ttgaagtgat tttaacttat tccggtttac atgctatatg 112501 ggcgcatcgg attgcacatg ctttatataa acgaaaattt tatttccttg cacgccttat 112561 atctcaagta agccgatttt ttaccgggat agaaatccac cccggcgcta caatcgggag 112621 aagatttttc atagaccacg gcatgggggt tgtcattggg gagacatgtg aaatcggcaa 112681 taacgtaacc gtttttcagg gggttaccct cgggggaacg ggaaaagaaa agggaaaaag 112741 gcacccaacg attaaagatg acgcattgat agccacaggt gctaaagtgc tcggttctat 112801 tacggtcggt gaaggctcaa agattggcgc tggttcagta gtgctgcatg atgttcctga 112861 tttttcaaca gttgtcggta tccctggacg ggtcgttgta caaaatggca agaaagtaag 112921 acgcgattta aaccatcagg atttgcccga tccagttgct gaccgcttta agtctttgga 112981 acagcagatt ttagagctga aggcagaact tgaagacaga aaagaaagga tcaatcaaaa 113041 atgacaatca cactttataa tacattgact agacagaagg aaacattcgt tcctcttgaa 113101 gagggaaaag tgaaaatgta tgtatgcgga cccacggttt acaattacat tcatatcggg 113161 aacgcgcgtc cggcaatcgt ttacgatacg gttcgaaact atttagagta taaaggctat 113221 gatgtgcagt atgtctctaa cttcacagac gtagacgata aattaattaa agcggcaaat 113281 gaactcggtg aggatgtacc caccatttca gagcgtttta ttaaagcata ctttgaagac 113341 gtaggtgcgc tcggctgccg aaaagccgac cttcatccgc gagtaatgga gaacatggat 113401 gccattatcg aattcgtaga tcagctcgtg aaaaagggct acgcatatga atcagaaggt 113461 gacgtatatt tcaaaaccag agcatttgaa gggtacggaa agctttctca gcaatcaatc 113521 gatgaactaa gatcaggtgc acgcatccgg gtcggcgaga aaaaagaaga tgctcttgat 113581 ttcgcactgt ggaaagcggc aaaagaagga gaaatctctt gggatagccc ttgggggaaa 113641 gggcgtccgg gctggcacat tgaatgctca gcaatggtga aaaagtatct cggtgaccag 113701 attgatatcc atgcgggcgg acaggattta acattccctc accatgaaaa cgaaattgcg 113761 caatctgagg cgctgacagg caaaacgttt gcgaagtact ggcttcataa tggttatatc 113821 aatattgata atgaaaaaat gtcaaaatca ctaggcaact ttgtgcttgt gcatgacatc 113881 attaaacagc atgatccgca gcttttgaga ttctttatgc tatctgttca ttatcgccat 113941 ccgattaact attcagaaga gcttctggag aatacgaaaa gcgcgttcag ccgtttaaaa 114001 acagcgtaca gcaatcttca gcaccgtctg aacagcagta cgaatttaac cgaagatgac 114061 gatcaatggc ttgaaaaggt tgaagaacac cgcaaagcat tcgaagaaga gatggacgat 114121 gattttaata cggcgaatgc catttcagtc ttgtttgact tagcgaaaca cgccaattat 114181 tatcttcaga aagatcatac ggctgatcat gtgattacgg cgtttattga gatgtttgac 114241 cgcattgttt ctgtcctcgg tttttcgttg ggtgagcagg aacttctcga tcaagagatt 114301 gaagacttaa tcgaaaagcg aaatgaagcg cgccggaatc gcgattttgc attgtcagac 114361 cagatccgcg accagctgaa aagcatgaat atcattcttg aagatacggc tcaaggcact 114421 cgctggaaac ggggagaata acagatgctt gaatttgata cgataaaaga ttctaagcag 114481 cttaacggtc ttgcgcttgc ttatataggt gatgccattt ttgaagtgta tgtcaggcat 114541 cacctgctta agcagggctt taccaaacca aatgatcttc ataagaaatc aagccggatt 114601 gtttcagcaa agtcacaggc tgagatccta ttttttctgc agaatcaatc attttttacg 114661 gaagaagagg aagcggtgct gaaaagaggc agaaatgcca agtcagggac aacacctaaa 114721 aatacagatg ttcagacgta ccgctacagt acagcatttg aagcgcttct gggctacctt 114781 tttctagaga aaaaagagga acgacttagt cagctcgtag ccgaagctat acaattcggg 114841 acgtcaggga ggaaaacaaa tgagtcagca acatgattac gtcataggga aaaatgcagt 114901 gatcgagacg ttaaaatctg atcggaagct gtataagctg tggatggcgg aaaacaccgt 114961 aaagggacaa gcacagcaag tgattgagct tgccaaaaag cagggaatca cgattcaata 115021 cgtcccgaga aaaaaactcg atcaaatggt gacaggacag catcagggcg tagtggcaca 115081 ggttgcagcg tatgaatatg cagaactgga cgatttatat aaagcagccg aagaaaaaaa 115141 tgaacagcct ttcttcctca ttctggacga gcttgaagac cctcataatc ttggttccat 115201 tatgaggaca gcagatgcgg tcggcgctca tggcatcgtc attccaaaac ggagagctgt 115261 cgggctgaca acaacagtgg caaaagcttc aacaggagca attgagcaca ttcctgtagc 115321 aagagtcacc aatttggcac ggacgttaga agagatgaaa gagcggggaa tctgggttgt 115381 cggaacggat gcgtccgcgc gtgaggattt ccgtaatatg gacggcaata tgcctttggc 115441 tctagtcatc ggaagtgaag gaaaagggat gggccgcctt gtgaaggaaa agtgcgattt 115501 tctcattaaa ctcccgatgg ccggaaaggt aacttcacta aatgcatctg tcgcggctgg 115561 tcttttgatg tatgaagtct accggaaacg aaaccctgtg ggagaataaa gacccatgga 115621 tatcctgtta gtagacgggt acaacatgat tggagcctgg ccgcagctga aggatttaaa 115681 agcgaacagt tttgaagagg cgagagacgt actgattcag aaaatggcgg aatatcaatc 115741 gtatacagga aacagggtta ttgttgtttt tgacgcgcat ctcgtaaaag ggcttgagaa 115801 aaaacagacc aaccatagag ttgaagtaat ttttacaaaa gaaaatgaga cggctgatga 115861 gcggatagaa aagctcgctc aggctttgaa taatattgcg actcaaattc acgttgcgac 115921 ctctgactat actgagcagt gggcgatttt cggacagggg gcattgcgga aatcggcccg 115981 ggagcttctg agagaggtag aaacgattga aaggcgaata gagagacggg taagaaaaat 116041 cacttccgaa aagccggcgg gtaaaattgc tttatcggaa gaggttttga aaacgtttga 116101 aaagtggagg cggggagact tagattaagt tgacgctttt ttgcccaata ctgtataata 116161 tttctatcta cgtgcgccgg ggggatcgga gtgaatctac agaacaacaa gggaaaattc 116221 aacaaagagc agttttgcca gttggaggac gagcaggtca ttgaaaaggt tcatgttggg 116281 gacagtgatg cgttagatta cttgattacg aagtaccgaa actttgttcg ggcaaaagca 116341 agatcctatt tcttaatagg ggcggacaga gaggatattg ttcaggaagg catgataggc 116401 ctctataagt ctattcgtga cttcaaagag gacaagctta cctcattcaa agcttttgca 116461 gaattatgta ttacccgcca aattattacc gcaataaaga cagctactcg ccagaaacac 116521 attcctttga attcctacgc ctcattagat aaaccgatct ttgatgaaga atcagaccga 116581 acgctgctgg atgtcatttc aggagcgaaa accttaaatc ctgaggaaat gatcattaat 116641 caggaagaat ttgatgatat tgaaatgaaa atgggagaac tattaagtga tttagagaga 116701 aaagtactcg tcttatatct cgacgggaga agttaccaag agatttctga tgaactgaac 116761 cgacatgtga aatcgatcga caatgccctt cagcgtgtga aacgcaagct ggagaagtac 116821 ttggaaattc gcgaaatcag tttgtaatag gaatttatgc tatattgaca gtatttttct 116881 gactatgata tgttactaaa gataagaact aatgtctatt tagaaaaagg tgtaatgaca 116941 tgagaaaaaa gattacgtta gcatgcaaga catgcggaaa ccgtaattat acgacaatga 117001 agagctctgc atcagcggct gagcgattag aagtaaagaa atactgcagt acttgcaatt 117061 cacatacagc tcatcttgaa acaaaatagt ttttgcgctt ttaaattgtg gaggtctttt 117121 acatgcgtat tatgaaattc tttaaagatg ttgggaaaga aatgaaaaag gtaagctggc 117181 ctaaaggaaa agagttaacg cgttatacca ttacggtaat ttcaacagtt atcttttttg 117241 ttatcttttt tgccctcctt gacacaggaa tttctcaatt aattcgttta atagttgaat 117301 aatgatcagc aatacgtgct ataatagatc ataatattac ttgccaaaac ccgttcagcg 117361 ggttttttat tgtggcttaa aatgaaagtt atcataggct tgccgcctat tttttgaagc 117421 gttatggtaa ttcactaaaa ccaaatgcgg ggagggaagg actggacagt cctgaataga 117481 atggaaaaga attggtatgt tgttcacacg tactctggtt atgagaataa agtaaaagcc 117541 aacttggaaa agcgtgttga atcaatgggg atgcaggata aaattttccg tgtagtcgta 117601 cccgaagaag aagaaacgga tatcaaaaac ggcaagaaaa aagtcgtgaa aaagaaagta 117661 ttccctggtt atgtgcttgt tgaaattgta atgacagacg actcttggta tgtcgtccgc 117721 aacacgccgg gcgttactgg attcgtagga tctgccgggt caggttcaaa accgacgccg 117781 cttcttccgg gggaagcaga aaccattctg aagagaatgg gcatggatga acgaaaaact 117841 gatattgact ttgaactgaa agagacagtg aaagtaatag acggaccttt tgctaacttt 117901 acaggatcaa ttgaagagat tgattatgat aaaagcaagg tcaaagtttt cgttaatatg 117961 tttggccgtg aaacgccggt tgagctggaa tttacccaaa tcgataaatt gtaatgtgaa 118021 aaaacttgaa attgctatat ataaatgata atatagcaaa ggtacgtctt ggacttatcc 118081 aaggcaacta gcatgatatt tcgtcattca tataaagaat gaaaccttga gtgggagggt 118141 ttaccctatt accacatcac ggacttaagg aggtgtgtct cgtggctaaa aaagtagtta 118201 aagttgtaaa attgcaaatt cctgctggaa aagctaaccc agcaccacca gttggacctg 118261 cacttggtca agccggtgtt aacatcatgg gattctgtaa ggagtttaac gctcgtacag 118321 ctgaccaagc tggtttaatc attcctgttg aaatttcggt ttacgaagac cgttcattta 118381 catttattac aaaaactcca cctgctgcag tattgcttaa aaaagcagct ggaattgagt 118441 ctggttctgg tgaaccaaac cgtaataaag tggcaaccgt taagcgcgat aaagtacgcg 118501 aaatcgctga aacgaaaatg cctgacttaa acgcagcaga cgttgaagcg gcaatgcgca 118561 tggttgaagg tactgcccgc agtatgggta ttgtaatcga ggattaattt gtttcttgtc 118621 gggttgcgag ttttaacaag ttcgcaaccc ttattcgtgg gaggttattc cgctataacc 118681 acataaggag gaaattttaa aatggctaaa aaaggtaaaa agtacgttga agctgctaag 118741 cttgtagacc gttctaaagc ttacgacgtc tctgaagcag tagctctcgt taaaaaaaca 118801 aacacagcta aattcgacgc tacagttgaa gtggctttcc gtttaggggt tgaccctcgt 118861 aaaaacgacc agcaaatccg tggagcagtt gtgcttccaa acggaactgg taaaactcag 118921 cgcgttctcg ttttcgcaaa aggcgaaaaa gcgaaagaag ctgaagctgc tggtgcagat 118981 ttcgtaggcg atactgacta catcaacaaa attcaacaag gctggttcga tttcgatgtt 119041 atcgtagcta cacctgacat gatgggtgaa gttggtaaaa tcggtcgtgt acttggacca 119101 aaaggtttaa tgccgaaccc taaaactggt acagttactt tcgaagttga aaaagctatc 119161 ggcgaaatca aagctggtaa agttgaatac cgcgttgata aagctggaaa cattcatgtt 119221 cctatcggta aagtttcttt cgaggatgaa aaacttgttg agaacttcac aacaatgtac 119281 gatacaatcc ttaaagctaa acctgctgca gctaaaggcg tttacgtgaa aaacgttgct 119341 gtaacttcta ctatgggacc tggtgtcaaa gtagactctt caacttttaa cgtaaaataa 119401 tattgacatg acatcaacat tctgatatta ttcaaaatgt tgtaaaatag aatatcattt 119461 ataccgtaga cagtaggggc ctaaccgctt aattatccta ccgaggtgta tattatcaca 119521 gctattacgt tacgtatgct tgtatataca gcctccatgt ctcatggagg ctttttatat 119581 ggaatccgtc gtctcagtcg tgatcaccta acggtataag tgttacacaa gaatctacag 119641 gaggtgtaac catgagcagc gcaattgaaa caaaaaaagt tgttgttgaa gaaattgctt 119701 ctaaactgaa agaaagtaaa tcaacgatca tcgttgacta tcgcggactt aacgtttctg 119761 aagtaactga acttcgtaaa cagcttcgcg aagctaacgt tgagttcaaa gtttacaaaa 119821 atacgatgac tcgccgtgcg gttgaacaag ctgagcttaa tggtttgaat gatttcttaa 119881 ctggaccgaa cgcgatcgca ttcagcactg aagatgttgt cgctccggct aaagttctta 119941 atgacttcgc taaaaatcac gaagctcttg aaatcaaagc tggcgttatc gaaggtaaag 120001 tttctactgt tgaagaagtg aaagctcttg ctgaacttcc atcacgcgaa ggcttgcttt 120061 ctatgttgct tagcgtactt caagctccag ttcgcaacct tgctcttgct gcaaaagctg 120121 tggcagaaca aaaggaagaa caaggcgctt aatctaatca gtttttcata aattaaaaca 120181 aaatggagga attacaaatg gctttaaata tcgaagaaat cattgcttcc gttaaagaag 120241 caactgtact tgaattgaac gacctagtaa aagcaatcga agaagaattt ggcgtaactg 120301 ctgctgctcc tgtagctgta gctggcggag ctgctgctgg cggagctgct gaagagcaaa 120361 gcgaattcga tcttatcctt gctggtgcag gatctcaaaa aatcaaagtt atcaaagttg 120421 tacgtgaaat cactggtctt ggcttgaaag aagctaaaga gcttgttgac aacactccaa 120481 aaccacttaa agaaggtatt gctaaagaag aagctgaaga gcttaaagct aaacttgaag 120541 aagttggcgc ttctgtagaa gttaagtaat cttcacttac ctgtagggga agctcgcttt 120601 tatgaggcga gctttttctt tgccattctt taagccatga aaaaaggagg ttctaataat 120661 gagtgagcac tattattcag aaaaaccttc agtaaaaagc aacaagcaaa cctggtcttt 120721 taggcttcgg aataaagatt tcacgtttac cagcgacagc ggggtttttt ctaaaaaaga 120781 agttgatttc ggctcccgcc tgctgattga ttcttttgaa gagcctgagg ttgagggcgg 120841 cattttagat gtaggctgcg gatacggccc gattggttta tcgctcgcca gcgactttaa 120901 agaccggacc atccacatga ttgacgttaa tgagagagcc gtagaactat caaatgaaaa 120961 tgcggaacag aacggaataa caaacgttaa gatttatcaa agcgatttgt tttcaaacgt 121021 tgattctgct caaacatttg cttctattct tacaaatccc ccaatccgag ccggaaaaaa 121081 agttgtccat gctatctttg agaaaagcgc tgaacactta aaagcttcag gtgaattgtg 121141 gatcgtcata cagaaaaagc aaggcgcgcc ttctgccatt gaaaagctcg aggaactgtt 121201 cgatgaagtt tccgtcgttc aaaaaaagaa aggctattat atcataaaag caaaaaaagt 121261 ttgactcggt attttaacta tgttaatatt gtaaaatgcc aatgtatata ttttgcttga 121321 tatgatgaat tgtcaatatc tatgtataaa ttatacaagt atggaaatgc taataaaatc 121381 ggtatttgtt tttggatgtg gttttcttaa ttagaaaccc ttttttcttt tgtcttgtaa 121441 aagtattttc tttctttgga agaaatgctt attacacata taatacgcat gatttgaggg 121501 gtgaatcagt tgacaggtca actagttcag tatggacgac accgccagcg cagaagctat 121561 gctcgcatta gcgaagtgtt agaattacca aatctcattg aaattcaaac ctcttcttat 121621 cagtggtttc ttgatgaggg tcttagagag atgtttcaag acatatcacc aattgaggat 121681 ttcactggta acctctctct tgagttcatt gattatagtt taggtgagcc taaatatcct 121741 gtagaggaat caaaagaacg tgatgtgact tactcagctc cgctaagagt gaaggttcgt 121801 ttaattaaca aagaaactgg agaggtaaaa gaccaagatg tcttcatggg tgatttccct 121861 attatgacag atacaggtac ttttatcatt aacggtgcgg aacgtgttat cgtttcccag 121921 cttgttcggt ctccaagtgt atatttcagt ggtaaagtag acaaaaacgg taaaaaaggt 121981 tttaccgcaa ctgtcattcc aaaccgtggc gcatggttag aatacgaaac tgatgcgaaa 122041 gatgttgttt atgtccgcat tgatcgcaca cgtaagttgc cggttacggt tcttttgcgt 122101 gctctcggct tcggctccga tcaagagatt cttgatctca taggagaaaa cgaatacctg 122161 cgaaatacgc ttgataaaga taacacagaa aacagcgaca aagcgttgct ggaaatttac 122221 gagcgtctcc gtcctggaga gccgcctaca gtagaaaatg cgaaaagctt gcttgattct 122281 cgtttctttg atccgaaacg atacgatctt gccaatgtag gacgctataa aattaataaa 122341 aaacttcata ttaagaatcg cctcttcaat cagagacttg ctgaaacgct tgttgatcct 122401 gaaacaggag aaatccttgc tgaaaaaggc cagattcttg atagaagaac gcttgataaa 122461 gtactgccat acttagaaaa cggaatcggt tttagaaagc tgtatccgaa tggcggcgtt 122521 gttgaagatg aagtgactct tcaatcaatt aaaatctttg ctccgactga tcaagaagga 122581 gaacaggtta tcaatgtaat cggcaatgct tacatcgaag aagagattaa aaacatcacg 122641 cctgctgata ttatttcttc aatcagctac ttcttcaacc tgctgcacgg agtaggcgac 122701 acagatgata tcgatcatct tggaaaccgc cgtttacgtt ctgtaggcga gcttctccag 122761 aaccaattcc gtatcggttt aagccgtatg gagcgtgtgg ttcgtgagag aatgtcaatt 122821 caagatacga atacaattac gcctcagcag ctgatcaata ttcgtcctgt tattgcgtcc 122881 attaaagagt tctttggaag ctcacagctt tctcaattca tggatcagac gaacccgctt 122941 gctgaattaa cgcacaagcg tcgtctgtca gcattaggac cgggcggatt gacacgtgag 123001 cgtgccggaa tggaagtgcg tgacgttcac tactcccact atggccgtat gtgtccgatt 123061 gaaacgcctg agggcccgaa catcggtttg atcaactcac tatcatctta tgcaaaagta 123121 aaccgttttg gctttattga aacgccatat cgccgcgttg accctgaaac agggaaggta 123181 acgggcagaa tcgattactt aactgctgat gaagaggata actatgttgt cgctcaagcg 123241 aatgctcgtc ttgatgacga aggcgccttt attgatgaca gcatcgtagc tcgtttccgc 123301 ggggagaaca ccgttgtttc cagaaatcgt gtagactaca tggatgtatc gcctaagcag 123361 gttgtatctg ctgcgacagc atgtatcccg ttcttagaaa acgatgactc caaccgtgcc 123421 ctcatgggag cgaacatgca gcgtcaggct gtgcctttga tgcagccgga agcgccattt 123481 gttggaactg gtatggaata cgtatcagga aaagactctg gtgccgctgt tatttgtaaa 123541 caccctggta tcgttgaacg cgtagaagcc aaaaacgttt gggttcgccg ttatgaagaa 123601 gtagacggtc aaaaagtaaa aggaaacctg gataaataca gcctgctgaa atttgtccgc 123661 tctaaccaag gtacgtgcta caaccagcgt ccgatcgtaa gtgtcggcga tgaagtggta 123721 aaaggagaaa tccttgctga cggtccttct atggagcttg gtgaacttgc acttggccgt 123781 aacgtaatgg tcggcttcat gacgtgggat ggctacaact atgaggatgc catcatcatg 123841 agtgaacgcc tagtgaagga tgatgtttat acatctatcc acattgaaga atacgaatca 123901 gaagcacgtg atacgaaact tggacctgaa gaaatcactc gcgatattcc aaacgtcggt 123961 gaagatgcgc ttcgcaatct tgatgaccgc ggaatcatcc gtattggggc agaagtaaaa 124021 gacggagatc ttcttgttgg taaagtaacg cctaaaggcg taactgaact gactgccgaa 124081 gaacgccttc ttcacgccat ctttggcgag aaagcccgcg aggttcgtga tacttctctt 124141 cgtgtgcctc atggcggcgg cggaattatc catgacgtta aagtcttcaa ccgtgaagac 124201 ggagacgaac ttcctccagg tgttaaccag ttagtacgcg tatatatcgt tcagaaacgt 124261 aagatttctg aaggggataa aatggccggt cgtcacggta acaaaggtgt tatctctaag 124321 attcttcctg aagaggatat gccttacctt cctgacggca caccaattga tatcatgctt 124381 aacccgctgg gcgtaccatc acgtatgaac atcgggcagg tattggaact tcacatgggt 124441 atggccgctc gttaccttgg cattcacatt gcatctcctg tatttgacgg agcgcgagaa 124501 gaggatgtct gggaaacact tgaagaagcc ggcatgtctc gtgacgccaa aacagtgctt 124561 tacgacggac gtactggaga gccgtttgat aaccgtgtat ctgtcggtat catgtacatg 124621 atcaaactgg ctcacatggt tgacgataaa cttcatgcac gctctacagg cccttactca 124681 cttgttacgc agcagcctct tggcggtaaa gcgcaatttg gcggacagcg ttttggtgag 124741 atggaggttt gggcacttga agcttacggt gcggcttaca ctcttcaaga aattctgact 124801 gttaagtctg atgacgtggt tggacgtgtg aaaacatacg aagccatcgt taaaggcgac 124861 aatgttcctg aaccaggtgt tccggaatca ttcaaagtat taatcaaaga acttcaaagc 124921 ttaggtatgg atgtcaaaat cctttctggt gatgaagaag aaatagaaat gagagattta 124981 gaagacgaag aagatgcgaa acaagctgac ggcctggcat tatcaggtga tgaagagccg 125041 gaagaaacag catctgcaga cgttgaacgc gatgtagtaa caaaagaata atctctagtt 125101 ataaaggcaa gtgacatcgg ttaatccgaa gataaaaagg gaggtaggcc ccttgctaga 125161 tgtgaacaat tttgagtata tgaacatcgg tcttgcttca ccagataaaa tccgttcatg 125221 gtcttttggt gaagtgaaaa agcctgaaac gataaactat cgtacgttaa aacctgaaaa 125281 ggacggtcta ttctgcgaac gcattttcgg accgactaag gactgggaat gtcattgcgg 125341 gaagtacaag cgagttcgtt ataaaggcgt agtttgtgac cgctgcggag tcgaagtaac 125401 acgggctaaa gtccgtcgtg agagaatggg gcacattgaa ctggctgccc cagtttccca 125461 catttggtat ttcaaaggta ttccaagccg tatgggtctt gtgctggata tgtcacctcg 125521 tgctttagaa gaagtcattt actttgcttc ttacgttgta actgatccgg cgaatacacc 125581 gcttgaaaag aaacagcttc tgtctgagaa agaataccgt gcttatcttg ataaatacgg 125641 taataaattc caagcatcta tgggtgctga agcaattcat aaacttcttc aagatatcga 125701 tcttgtaaaa gaagttgata tgttaaaaga agagctgaaa acttcacaag gacaacgccg 125761 tactcgtgcg atcaaacgtc ttgaagtttt agaagccttc cgtaactcag gaaacaagcc 125821 ttcttggatg atccttgatg tgcttcctgt tattcctccg gagcttagac cgatggttca 125881 gctagatggc ggacgttttg cgacttctga tttgaatgac ctttatcgtc gtgtcatcaa 125941 ccgtaacaat cgtttgaaac gccttttgga ccttggtgcg cctagcatca tcgttcaaaa 126001 cgaaaagcgt atgcttcaag aggctgtcga tgccctaatt gacaacggcc gccgcggacg 126061 ccctgtaaca ggtcctggaa acagaccgtt aaaatctctt tctcacatgc tgaaagggaa 126121 gcaaggccgt ttccgtcaaa accttcttgg taaacgtgtc gattactccg gacgttctgt 126181 aatcgttgtt ggtcctcatt tgaaaatgta ccaatgcgga ttaccgaagg aaatggcact 126241 tgaacttttc aaacctttcg ttatgaaaga acttgttgaa aaaggtcttg ctcacaacat 126301 taagagtgcg aaacgcaaaa ttgagcgcgt acagcctgaa gtttgggatg tactagaatc 126361 agttattaag gagcatccgg tactgctgaa ccgtgcccct acacttcaca gattaggtat 126421 ccaggcgttt gaaccaacgc ttgttgaagg acgcgcaatc cgtcttcacc cgctcgtatg 126481 tacagcttac aacgctgact ttgacggtga ccaaatggcg gttcacgtac cattatctgc 126541 tgaagcacaa gctgaagcac gcatcttgat gcttgctgct caaaacatct tgaaccctaa 126601 agatggtaaa ccggttgtaa caccgtctca ggatatggta ctaggtaact attacctgac 126661 acttgagcgt gccggtgctg tcggtgaagg tatggtcttc aagaatacag acgaagcgct 126721 tcttgcttat caaaacggat atgttcacct tcatacgaga gtagctgttg cagctaactc 126781 acttaagaat gtgacattta ccgaagaaca gcgctcaaaa ttgttaatta caactgtcgg 126841 taagcttgtc ttcaatgaaa ttcttccgga atcattccct tacatgaatg aaccaacgaa 126901 gagcaacatt gaagagaaaa cacctgaccg tttcttctta gaaaaaggtg ctgatgttaa 126961 agctgttatc gcacagcagc caatcaatgc gccgtttaaa aaaggcattc tgggtaaaat 127021 catcgcggaa atctttaaac gattccatat tacggaaacg tctaaaatgc ttgaccgcat 127081 gaaaaaccta ggtttcaaat attcaactaa agctggtatt acagttgggg tttctgacat 127141 cgtcgtactc gatgataaac aagaaattct tgaggaagcg caaagcaaag ttgacaacgt 127201 tatgaagcaa ttccgccgcg gtcttatcac tgaagaagaa cgctatgaga gagtcatctc 127261 tatctggagt gctgcaaaag acgttatcca aggcaaactg atgaaatcac ttgatgaact 127321 caacccgatc tacatgatga gtgactctgg tgcccgtggt aacgcatcta actttacgca 127381 gcttgccgga atgcgcggcc tgatggccaa cccggctgga cgtatcattg agttgccgat 127441 caaatcaagt ttccgtgaag gtctgacagt attggagtac tttatctcca cacacggtgc 127501 gcgtaaaggt cttgccgata ccgctcttaa aactgctgac tcaggttacc ttacacgccg 127561 tctcgttgac gttgctcagg atgttatcat ccgtgaaact gattgcggaa ctgaccgagg 127621 cattcttgct aagcctctta aagaaggaac tgaaacaatt gagcgcttag aagaacgctt 127681 aatcggacgt tttgcaagaa aacaagtgaa gcaccctgaa acaggtgaag tgcttgtgaa 127741 tgaaaacgaa ctgatcgatg aagataaagc actggagatt gtcgaagccg gcattgaaga 127801 agtgtggatc cgttctgcct tcacatgtaa tacgcctcat ggtgtatgta aacgatgcta 127861 tggccgaaat cttgcaactg gctccgatgt tgaagtcggt gaagctgtcg gaatcattgc 127921 tgcccaatca atcggtgagc ctggtacaca gttaacaatg cgtacattcc atacaggcgg 127981 ggttgccgga gacgatatca cacagggtct tccgcgtatc caagagcttt tcgaagcgcg 128041 taatccgaaa ggtcaggcaa caattacaga aatcgacggt acagtcgttg agatcaatga 128101 agttcgtgat aagcaacagg aaattgtggt tcaaggcgca gtggaaacac gttcttatac 128161 ggcaccttac aactcccgcc tgaaagtagc ggaaggagat aaaattactc gaggccaagt 128221 actgacagaa ggttcaatcg atccgaaaga acttcttaaa gtgactgacc tgacgactgt 128281 tcaagagtat cttctccatg aggttcaaaa ggtttaccgt atgcagggtg ttgaaatcgg 128341 tgataaacac gtagaagtaa tggttcgcca gatgcttcgc aaagtacgcg tgattgatgc 128401 cggtgacact gatgtgcttc caggtacatt gcttgatatt caccaattta ctgaagcgaa 128461 caaaaaggta ttgcttgaag gcaaccgacc agctacaggc cgtcctgtct tactcggtat 128521 tacaaaagca tctcttgaaa ctgattcatt cttatctgct gcttccttcc aggaaacaac 128581 acgtgtcctt acagatgcag cgatcaaagg taagcgtgac gagcttctcg gcttgaaaga 128641 gaatgttatc atcggtaagc ttgttccagc aggtacagga atgatgaaat accgtaaagt 128701 aaaaccagta tcaaatgttc agccgactga cgatatggtc ccggttgaat aactgattta 128761 actctgctga aagactgcaa aaacagtctt tcagcagata tatttatgaa aaagtcactc 128821 tatgagaaga acgaatctaa aaaatgtcat accttgttga cattcgtctc ctagaatgat 128881 aatataacca aggtgctcga aataaacctg ttactttgga ggatatgttt atgtcttatg 128941 ataaagtatc acaggccaaa tcaattatta ttggtacgaa gcaaacagtg aaagctctaa 129001 agcgaggttc agtaaaggaa gtagtcgttg caaaagacgc agatccgata ctcacgtcaa 129061 gtgttgtttc acttgctgaa gatcaaggta tctctgtctc aatggttgaa tccatgaaaa 129121 agctcggcaa agcctgcgga attgaggtag gagcagccgc tgttgccatt attttataac 129181 gtacttttgt ttttgcgtaa gattccatct tgtgtaaaga cattgttttt tgccttttga 129241 tgaaccacct gggtatgtgg gttataaaac gtaatgaagg gaggaaaaat tcatgcctac 129301 aattaatcag ctaattcgca aaggacgcgt gagtaaagta gaaaactcaa agtctcctgc 129361 acttaacaaa ggatacaaca gctttaaaaa agagcacact aacgtatctt ctccacaaaa 129421 acgcggggta tgtactcgtg ttggtacaat gacaccgaaa aaaccgaact cagcacttcg 129481 taaatatgct cgtgttcgtt tgactaacgg aatcgaggtt actgcttaca ttcctggtat 129541 cggtcacaac ctgcaagagc acagtgttgt acttatccgc ggcggacgtg taaaagactt 129601 accaggggta cgttaccaca tcgttcgtgg tgcgcttgat actgctggag ttgaaaaccg 129661 tgcacaaggc cgttctaaat acggtacgaa aaaacctaaa gcaaaataat atacgaaaat 129721 acgcataatt gatgaaggga ggatattcag atgccacgta aaggtcctgt agcaaaaaga 129781 gatgttttac ctgatccgat ttacaactct aagcttgtat ctcgtttaat caacaaaatg 129841 atgatcgatg gtaaaaaagg taagtctcaa acgatcctat acaagtcatt cgatatcatt 129901 aaagaacgta ctggcaatga tgcaatggag gttttcgaac aagcattgaa aaacatcatg 129961 cctgtacttg aagtaaaagc acgccgtgta ggtggtgcga actaccaagt tcctgtagaa 130021 gttcgtcctg aacgtcgtac gactcttgga cttcgctggt tagttaacta cgctcgtctt 130081 cgtggagaaa aaacgatgga agagcgttta gctaacgaaa tccttgacgc agctaacaac 130141 actggtgctg ctgttaagaa acgtgaagac actcataaga tggctgaagc aaacaaagca 130201 tttgctcact atcgctggta ggatttatag attaacaaaa cacaatttcc taataaggaa 130261 ggagaaatta cccaatggca agagagttct ccttagaaaa aactcgtaat atcggtatca 130321 tggctcacat cgatgccggt aaaacgacta ctacagaacg tatcttgttc tatactggtc 130381 gtatccacaa aattggtgaa actcatgaag gagcttcaca aatggactgg atggagcagg 130441 aacaagaacg tggtatcaca atcacttccg ctgcgactac tgcacagtgg aaaggatacc 130501 gcgtaaacat catcgatact ccaggacacg tagacttcac agttgaagtt gaacgttctc 130561 ttcgtgtact tgatggtgct gttgctgtac ttgacgcgca atcaggcgtt gagcctcaaa 130621 cagaaactgt ttggcgtcag gcaacaactt atggagtacc gcgtatcgtt tttgttaaca 130681 aaatggacaa aatcggtgca gacttccttt actctgtagg aactttaaga gaccgtcttc 130741 aagcaaacgc tcatgcaatt caattgccga tcggtgctga agataacttc gaaggtatca 130801 ttgaccttgt agaaaacgtt gcgtatttct acgaagatga cctcggaact cgttctgatg 130861 caaaagaaat ccctgaagag tacaaagagc aagctgaaga gcttcgcaac agccttattg 130921 aagctgtatg tgagcttgat gaagagctta tggataagta ccttgagggt gaagaaatca 130981 caattgacga gttaaaagca ggaattcgta aaggtacatt aaatgttgaa ttctaccctg 131041 ttcttgttgg ttctgccttc aaaaacaaag gtgttcaact agtacttgat gctgttcttg 131101 actaccttcc tgcaccaact gacgttgctg caatcaaagg tacacgtcct gatacaaatg 131161 aagagattga gcgtcattct tctgacgaag agccattctc tgcattagca tttaaagtta 131221 tgactgaccc ttacgttggt aagttgacgt tcttccgtgt gtactctgga acacttgatt 131281 ctggttcata cgtgaaaaac tctactaaag gcaaacgtga gcgtgttgga cgtattcttc 131341 aaatgcacgc taacagccgt gaagaaatct ctactgtata cgcaggggat atcgcagctg 131401 ctgtaggtct aaaagataca actactggag atactctatg tgatgagaag gatcttgtta 131461 tccttgagtc aatggaattc ccagaaccag ttatcgacgt tgctattgag cctaaatcaa 131521 aagctgacca agataaaatg ggtatcgctt tagcgaaact tgctgaagaa gatcctacat 131581 tccgtactca aacaaaccca gaaactggcc aaacgatcat ctctggtatg ggtgaacttc 131641 accttgatat cattgttgac cgtatgaaac gcgaatttaa agtagaagcc aatgttggtg 131701 ctcctcaagt tgcgtaccgt gaaacattcc gtaccggtgc aaaagttgaa ggtaaattcg 131761 tacgtcagtc tggtggacgc ggtcagttcg gacacgtttg gatcgaattc gaaccaaacg 131821 aagaaggcgc tggctttgaa tttgaaaatg cgattgtcgg tggggtcgtt cctcgtgaat 131881 acatcccagc tgttcaagca ggtctggaag atgcactcga aaatggtgta ctagcaggct 131941 tcccgcttat cgacattaaa gctaaacttt tcgacggttc ttaccatgat gttgactcaa 132001 acgaaatggc atttaaagtc gctgcttcta tggcattgaa aaatgcagtc agcaaatgta 132061 acccagttct tcttgaacca atcatgaaag tggaagtggt tattccagaa gaatatatgg 132121 gagatatcat gggtgatatc acttcacgtc gcggacgcgt agaaggtatg gaagcacgcg 132181 gtaacgctca agttgttcgt gctatggttc ctcttgctga aatgttcggt tacgctactg 132241 cacttcgttc taatacgcaa ggtcgcggta cgttcactat gcacatggat cactacgaag 132301 aagtgccgaa gagcgtcgca gaagaaatta tcaaaaaaaa taaaggcgaa taattgattt 132361 tgccgcttaa ctcaagtata actactattg taagatgagg aagtgaaagc tttctttcac 132421 ttcctatcac tctatacatt actaattaaa agctcttaag gaggatttta gaatggctaa 132481 agaaaaattc gaccgttcca aatcacatgc caatattggt acaattggac acgttgacca 132541 tggtaaaaca actttaactg ctgctatcac aacagtactt cataagaaat ctggtaaagg 132601 tacagctatg gcgtacgatc aaattgatgg tgctccagaa gaacgcgagc gcggtatcac 132661 aatctctact gcacacgttg agtacgaaac tgaaactcgt cactatgcac acgttgactg 132721 cccaggacac gctgactatg ttaaaaacat gatcactggt gctgcgcaaa tggacggagc 132781 tatccttgta gtatctgctg ctgatggccc aatgccacaa actcgtgagc acatccttct 132841 ttctaaaaac gttggtgtac catacatcgt tgtattctta aacaaatgcg acatggtaga 132901 cgacgaagag cttcttgaac tagttgaaat ggaagttcgc gatcttctta gcgaatacga 132961 cttccctggt gatgatgtac cagttgttaa aggttctgct cttaaagctc ttgaaggaga 133021 cgctgagtgg gaagctaaaa tcttcgaact tatggatgcg gttgatgagt acatcccaac 133081 tccagaacgc gacactgaaa aaccattcat gatgccagtt gaggacgtat tctcaatcac 133141 tggtcgtggt acagttgcta ctggccgtgt agaacgcgga caagttaaag tcggtgacga 133201 agttgaaatc atcggtcttc aagaagagaa caagaaaaca actgttacag gtgttgaaat 133261 gttccgtaag cttcttgatt acgctgaagc tggtgacaac attggtgccc ttcttcgcgg 133321 tgtatctcgt gaagaaatcc aacgtggtca agtacttgct aaaccaggta caatcactcc 133381 acacagcaaa ttcaaagctg aagtttacgt tctttctaaa gaagagggtg gacgtcatac 133441 tccattcttc tctaactacc gtcctcagtt ctacttccgt acaactgacg taactggtat 133501 catccatctt ccagaaggcg tagaaatggt tatgcctgga gataacactg aaatgaacgt 133561 tgaacttatt tctacaatcg ctatcgaaga aggaactcgt ttctctattc gtgaaggcgg 133621 acgtactgtt ggttcaggcg ttgtttctac aatcactgag taatagtatg gttttaaacg 133681 agacccctgt gggtctcgtt ttttgtttgc ttatcttttt cttgtataat aggatctatc 133741 atattcgagg ggttaatatt tatgattcct gaaaagaaat caatcgcaat catgaaagaa 133801 ctaagcattg gaaatacaaa gcaaatgctg atgattaatg gagttgacgt gaaaaatcca 133861 ttgctgcttt ttttacatgg cgggccggga acgccgcaaa tcggatatgt tagacattat 133921 caaaaagagc tggaacagta ttttacagta gttcattggg atcagagagg atcggggctt 133981 tcttattcta agcgaatttc gcatcactct atgacaataa atcacttcat taaagataca 134041 atccaagtca ctcaatggct tttagctcat ttttcaaaat caaaacttta cctagccggt 134101 cattcttggg gatcaatact ggcgcttcat gtgctgcagc agcgtcctga tttattttac 134161 acgtattatg gaatcagcca ggttgttaac ccgcaagatg aagaatcaac tgcttatcaa 134221 catattcgtg aaatttccga atcaaaaaaa gccagcatat tatctttcct tacacgtttc 134281 attggtgctc cgccttggaa gcaggatatc cagcacctta tctatcggtt ttgtgttgag 134341 ctaaccaggg gaggattcac tcaccgtcat cgtcaatctc tcgctgtatt atttcaaatg 134401 cttactggca atgagtatgg agtgcggaac atgcacagct tccttaatgg attgcgcttc 134461 agtaaaaaac atttaactga tgagttgtac cggtttaatg cttttacatc agttccttct 134521 attaaagtac cgtgtgtttt catttcaggg aaacatgact taattgttcc tgcagaaata 134581 tcgaaacagt attatcaaga acttgaggca cctgaaaagc gctggtttca atttgagaat 134641 tcagctcaca ccccgcatat tgaggagcca tcattattcg cgaacacatt aagtcggcat 134701 gcacgacacc atttatgata gatccttgat aaataagaaa aacccctgta taataaaaaa 134761 agtgtgcaaa tcatgcatat tttaaataag tcttgcaaca tgcgcctatt ttctgtataa 134821 tggtgtatgt tggtctttga ctgcgatgaa gtgagaggtt gctgacacac ccggccgctt 134881 tgccatggca aggtgttcag gtttttctca cggagaactg tctaacgtga tgtaggcgaa 134941 aaggagggaa aataatggca aaacaaaaaa ttcgtattcg tttgaaagca tatgatcata 135001 gaatccttga tcaatctgca gagaagattg ttgaaacggc aaaacgttct ggtgccagcg 135061 tatctggtcc gattccgttg ccaactgaaa aatcagttta cacaatcctt cgtgcggtgc 135121 acaaatacaa agattctcgt gagcaatttg aaatgcgtac acataaacgt ttaatcgaca 135181 ttgtgaaccc aacaccacaa actgttgatg ctcttatgcg attagactta ccatctggtg 135241 tcgatatcga aattaaactt taattctaaa atatagaatg atcttaatag gaggtgtgac 135301 gaatgaccaa aggaatctta ggaagaaaaa ttggtatgac gcaagtattc gctgagaatg 135361 gtgatcttat tccggtaact gttatcgagg ctgctccaaa cgttgttctt caaaagaaaa 135421 cagctgaaaa cgacggttac gaagcaatcc agcttggttt tgacgacaag cgtgaaaagc 135481 tttctaacaa acctgaaaaa gggcacgttg caaaagcgga aactgctcct aagcgcttcg 135541 ttaaagaatt acgcggagtg gaaatggatg cgtatgaagt tggtcaggaa gtcaaggttg 135601 aaattttctc tgctggagaa atcgtagatg taacaggagt atctaaaggt aaaggtttcc 135661 aaggtgcgat caagcgccac ggacaatctc gcggacctat gtctcacggt tcacgctacc 135721 accgtcgtcc tggttcaatg ggacctgtag atcctaaccg tgtattcaaa ggtaaattat 135781 tacctggacg tatgggcgga gagcaaatca ctgttcaaaa ccttgaaatc gtaaaagttg 135841 atgcagaacg caatcttctt ttgatcaaag gtaacgtacc tggtgcgaag aaatctttaa 135901 tcactgttaa aagtgctgtt aaatctaaat aattctctta ggaaaggagg aaattgatta 135961 tgccaaaagt agcattatac aaccaaaacg gttctactgc tggtgacatc gaattaaacg 136021 cttctgtatt tggtatcgaa ccaaatgaga gtgttgtatt cgacgctatt cttatgcaaa 136081 gagcttcctt acgtcaagga actcacaaag taaaaaatcg ttctgaagta cgcggcggag 136141 gtcgtaaacc atggcgtcaa aaaggtactg gacgtgcccg tcaaggttca atccgttcac 136201 cgcaatggcg cggaggtggt gtcgtattcg gcccaacacc acgcagctat tcttataaat 136261 tacctaaaaa agttcgccgc ttggcaatca aatcagtatt gtcttctaaa gtgatcgaca 136321 acaacatcat cgttcttgaa gatcttactc ttgatacggc taaaacaaaa gaaatggcag 136381 ctatccttaa aggattatct gttgagaaaa aagctttaat cgtaactgcg gatgcaaacg 136441 aagcagtagc attatctgct cgtaacattc ctggagttac tgttgttgaa gctaacggaa 136501 tcaacgtttt agacgttgtc aaccacgaga agcttctgat tacaaaagca gcggttgaaa 136561 aagtagagga ggtgcttgca taatgaaaga tcctcgtgat gttctaaagc gccccgtcat 136621 tactgaacgt tctgccgatt taatgactga aaaaaaatat acttttgaag ttgatgtaag 136681 agctaacaaa acagaagtga aagacgcggt tgaaagcatc tttggagtga aagttgacaa 136741 agtcaacatc atgaactaca aaggcaaatc aaaacgtgtt ggacgctaca ctggtatgac 136801 tagccgtcgc agaaaagcga tcgtaaaact tactgcagac agcaaagaaa tcgaaatttt 136861 tgaagcttaa ttatctgtaa aaagaaggag ggaaattcaa aatggcgatt aaaaagtata 136921 aaccgacctc taatggacgt cgtggcatga caacttcaga ttttgctgaa atcacgactg 136981 acaagccgga aaaatccttg cttgctcccc ttcacaaaaa aggcggacgt aacaaccaag 137041 gtaaattgac tgtacgtcac caaggtggcg gacataaacg ccaataccgt gttatcgact 137101 tcaaacgcga taaagatggt atacctggac gcgttgctac agttgaatac gatccaaacc 137161 gttcagctaa catcgctcta atcaactatg cagacggaga aaaacgttac attcttgctc 137221 ctaaaggaat tcaagtaggt actgaaatca tgtcaggtcc tgaagctgac attaaagtag 137281 gtaatgcact tccacttatc aacatccctg ttggtacagt tgtgcataac attgaattaa 137341 aacctggtaa aggcggacag cttgtacgtt cagctggtac atctgctcag gttcttggta 137401 aagaaggtaa atacgttctt gtacgtctta actctggtga agttcgcatg atcctttctg 137461 cttgccgtgc ttctatcggt caagtaggta acgaacagca cgaacttatc aacattggta 137521 aagctggacg ttctcgctgg aaaggcatcc gtcctacagt tcgtggttct gtaatgaacc 137581 ctaacgatca cccacacggt ggtggtgaag gacgtgcgcc aatcggacgt aaatcaccaa 137641 tgtctccatg gggcaaacca actcttggat tcaagactcg taagaaaaag aacaaatccg 137701 ataaatttat cgtacgtcgt cgtaaaaata aataacgggg ttgtctacgg ttcttttcgg 137761 accgtagtgc aatcacgaag ggaggttcca aaatggctcg cagcttaaaa aaaggaccat 137821 ttgtcgatgg acacttgatg actaaaatcg agaaattaaa tgaaacagac aagaaacaag 137881 tcgtaaaaac ttggtctcgt cgttctacta ttttcccaca gtttattggt cacacaatcg 137941 cagtctatga cggacgtaaa cacgtgcctg tattcatctc tgaagatatg gtagggcaca 138001 agttgggtga attcgctcca actcgtacgt acaaaggtca tgctagtgat gacaaaaaaa 138061 caagacgcta agagaggagg cttttaaatg caagctaaag ctgttgcaag aacagtccgt 138121 attgctcctc gtaaagcacg tctagtaatg gacctgattc gaggcaagca agtaggtgag 138181 gcagtatcaa tcttgaacct tacaccaaga gctgcttctc caattatcga gaaagtatta 138241 aaatccgcta ttgcaaatgc tgagcataac tatgaaatgg acgctaacaa cctggttatt 138301 tctcaagcat tcgttgacga aggccctacg ttaaaaagat tccgcccacg tgctatggga 138361 cgtgcgagcc aaatcaacaa acgtacgagc cacattacaa tcgttgtatc agaaaagaag 138421 gagggataag tagtgggtca aaaggtaaat ccagtcggtc ttcgtatcgg agtcattcgt 138481 gattgggaat ctaagtggta cgctggtaaa gattacgctg acttcctgca cgaagattta 138541 aaaattcgtg aatacattag caaacgcctt tctgacgctt ctgtttctaa agtagaaatt 138601 gagcgtgcag caaaccgcgt taacattacg atccacacag ctaagcctgg tatggttatc 138661 ggtaaaggcg gttctgaagt cgaagcactt cgcaaagccc ttaacagcct tactggcaag 138721 cgtgtacaca ttaacattct tgaaatcaaa agagcagatc ttgatgcaca gctagttgct 138781 gacaacatcg ctcgtcaatt agaaaaccgt gtttctttcc gccgtgcgca gaaacaacaa 138841 atccaacgta ctatgcgtgc tggagcacaa ggtgtgaaaa caatggtttc tggtcgtctt 138901 ggcggtgcag atatcgctcg ttctgaatac tacagtgaag gaactgttcc attgcacaca 138961 ttacgtgcgg acattgacta tgcaacatct gaagctgata ctacttacgg taagcttggt 139021 gtaaaagtct ggatctatcg tggagaggtt cttcctacta agaagaaaaa tgaggaagga 139081 ggaaaataat atgttattac caaaacgcgt taaatatcgc agagagcatc gcggaaaaat 139141 gcgtggccgt gcgaaaggcg gtactgaagt acatttcgga gaattcggta tccaagctct 139201 agaagcttct tggattacta accgtcaaat cgaagctgca cgtattgcga tgactcgtta 139261 catgaaacgt ggcggtaaag tttggatcaa aattttccct tctaaacctt acactgctaa 139321 accacttgag gtacgtatgg gatccggtaa aggggctcca gaaggttggg tagctgttgt 139381 aaaaccgggc aaagttttat ttgaaatttc tggtgtgtct gaagaggttg ctcgtgaagc 139441 gcttcgcctt gcatctcaca aattgccaat taaaacgaag ttcgtaaaac gtgaagaaat 139501 tggtggtgaa tcaaatgaaa gctaatgaaa ttcgtgacct taccactgct gaaattgaac 139561 aaaaagtaaa gtctcttaaa gaagaacttt tcaatcttcg ctttcaatta gcgacaggac 139621 aacttgaaaa tactgctcgc attcgtgaag tgcgcaaagc tatcgcgcgc atgaaaactg 139681 tgattcgtga aagagaaatt gctgctaata aataatcact gaggggaggt cgtgagcatg 139741 agcgaacgta accaacgcaa agtttaccaa ggccgtgttg tttctgacaa aatggataaa 139801 accattactg ttgttgttga gacatacaaa aaacatacac tttacggtaa acgcgtaaaa 139861 tactcaaaaa aattcaaagc acatgatgaa aataatcaag ctaaaatcgg tgacatcgtt 139921 aagatcatgg aaactcgtcc attgtctgca actaagcgtt tccgtctagt tgaagttgtc 139981 gaagaagctg ttattatcta ataaagttcg gaattctttt tccgaaggga ggtaacaaat 140041 aatgattcaa caagagactc gtttaaaagt agctgacaac tctggcgcac gtgaagtact 140101 tactattaaa gttcttggtg gttctggacg taaaacagct aacattggtg atgtaattgt 140161 ttgcacggtt aaacaagcaa caccaggagg cgttgtcaaa aaaggtgaag tcgtaaaagc 140221 tgttatcgtt cgcactaaaa gcggagcgcg cagaagtgac ggttcataca tcagcttcga 140281 tgagaatgca tgtgttatca tccgtgacga caagagccca cgcggaactc gtatcttcgg 140341 accagttgct cgtgaattgc gtgaaaacaa ctttatgaaa attgtttctc tagctccaga 140401 agttatctaa ttgaaataaa tgccttactc aaggaggtgc gatcaggatg catgtaaaaa 140461 aaggcgataa agttatggtt atctctggta aagataaagg caaacaagga acaatccttg 140521 ctgctttccc taaaaaggac cgcgttttag ttgaaggtgt taacatggta aagaaacact 140581 ctaaaccaac tcaagctaac cctcaaggcg gtatttctaa tcaagaggcg ccaattcatg 140641 tatcaaacgt tatgccgctc gatcctaaaa caggtgaagt gactcgcgta ggatacaaag 140701 tggaagatgg caaaaaagtt cgtgtagcaa aaaaatctgg gcaagttcta gataaatagt 140761 attaaaagga agggaggtct atctcatgaa ccgccttaaa gaaaagtaca ataaagaaat 140821 tgcacctgct ttaatgacta agttcaacta tgattcagtc atgcaagtgc ctaaaatcga 140881 aaaaatcgta atcaacatgg gtgttggtga cgctgttcaa aacgccaaag caatcgacag 140941 tgctgttgag gaattaacgt ttatcgcagg tcaaaaacct gtcgttactc gtgcgaagaa 141001 atcaattgct ggattccgtc ttcgtgaggg aatgcctatc ggtgcgaaag taactcttcg 141061 cggagagcgc atgtatgatt tccttgataa acttatttct gtatctttac cgcgtgtacg 141121 tgacttccgc ggggtttcta aaaaatcttt cgacggtcgc ggtaactaca cacttggtat 141181 caaagaacag ttaatcttcc ctgaaattga ctacgataaa gtaacaaagg ttcgcggaat 141241 ggacatcgtt atcgtaacaa ctgctaatac tgacgaagaa gctcgtgagc tattaactca 141301 agtaggtatg ccgttccaga aataatcaat gaaagggagg cgaaatcgtg gctaaaaagt 141361 ctatgattgc gaaacaacaa cgtacaccaa agtttaaagt acaagagtac acacgctgtg 141421 aacgctgcgg acgtccgcat tcagtcattc gtaaatttaa actttgccgt atttgtttcc 141481 gtgagcttgc atataaagga caaattcctg gcgtgaaaaa agccagctgg taatccccaa 141541 gaaagggaag gaggtaatta tataatggtt atgacagatc caattgcaga tatgctaact 141601 cgtattcgca atgcaaacat ggtacgtcat gagaagcttg aaattcctgc ttctaaattg 141661 aaaagagaaa ttgctgaaat tttaaagcgt gaaggtttca ttcgtgacgt tgagttcgta 141721 gaagacagca aacaaggtat tatccgcgtt ttcttgaaat acggacaaaa caacgagcgc 141781 gttatcactg gtcttaaaag aatcagcaag cctggtttgc gtgtttatgc taaatctaat 141841 gaagtacccc gcgtacttaa cggtcttgga atcgcgatta tttctacatc acaaggtgtt 141901 ttaacggaca aagaagcccg tgcaaaacaa gctggtggag aagttctagc atacgtttgg 141961 taagaagttt aacatgaatg gaggtgtttg gtatgtctcg tgtaggtaag aagctacttg 142021 agattccttc tgatgttaca gtaacgttaa atgataacaa cactgtagct gtgaaaggac 142081 caaaaggaga attaactcgt acgtttcacc ctgatatgga gattaaagta gaggacaatg 142141 tgcttacagt cgctcgtcct tctgatcaaa aagagcaccg tgccctgcat ggtacgactc 142201 gcagtctgct tggcaacatg gttgaaggtg tatctaaagg atttgaaaga ggtttggaat 142261 tagtcggtgt cggttaccgt gcttctaaat ccggaaataa acttgtttta aacgttggat 142321 actctcatcc tgttgagatc gttcctgaag aaggcatcga aatcgaagtt ccttctcaaa 142381 caaaagtagt tgtaaaaggt acagacaaag aacgcgtagg agctattgct gctaacatcc 142441 gcgctgtacg ttctccagag ccttacaaag gtaaaggaat ccgctacgaa ggtgaagttg 142501 ttcgccgtaa agaaggtaaa tctgctaagt aagatcgctt aaagtgaaga aaggagtgac 142561 ctagatgatt acgaaaacta gcaaaaatgc tgctcgtctt aaaagacacg ctcgtgttcg 142621 cgctaaactt tccggtactg ctgaaagacc gcgcctgaac gttttccgtt ctaacaagca 142681 catttacgct caaatcatcg atgatgtaaa tggtgtaaca cttgctagtg catctactct 142741 cgataaagac ttgaacgttg aaagcactgg agatacttct gctgctacta aagttggaga 142801 attagttgca aaacgcgctg ctgaaaaagg catttctgac gtagtatttg accgtggcgg 142861 atacttatac catggacgtg taaaagcttt ggctgatgcc gctcgtgaag ctggacttaa 142921 attttaataa aagaaggagg gacacatgat tatgcgtcgt attgacccaa gcaaattaga 142981 gttagaagaa cgcttagtta cggttaaccg cgtagcgaaa gttgttaaag gtggtcgtcg 143041 tttccgcttc gcagctctag tcgttgtcgg tgacaaaaac ggacacgtag gattcggtac 143101 tggtaaagca caagaagtac cagaagcgat tcgcaaagct gttgaagatg cgaaaaagaa 143161 tttgattgaa gtaccaatgg ttggaactac aattccacac gaaatcatcg gacgtttcgg 143221 tgcaggtaac atcttgttaa aacctgcttc tgaaggtact ggagttatcg ctggaggccc 143281 tgtacgtgcg gtacttgagc tagctggtgt agctgatatc ctttctaagt ctttaggttc 143341 taacacaccg atcaacatga ttcgtgcaac acttcaaggt ttaagtgaac ttaaacgtgc 143401 tgaagacgtt gcgaagcttc gtggaaaatc tgtagaagaa ctgttaggat aaggagggaa 143461 cattaatggc taaattagaa attaccctca aacgaagtgt aatcggtcgc ccggaagacc 143521 aacgcgttac tgtaagaaca cttggtttaa agaaaacaaa ccaaactgtt gttcatgaag 143581 acaacgctgc gatccgtggt atgattaata aagtatctca tttagtttct gttaaagaac 143641 aataaaaata tttgatcgga taaggaggtg tcctaatgaa acttcatgaa ttaaaacctt 143701 cagaaggttc acgcaaaacg cgtaatcgcg taggtcgtgg tattggttct ggcaacggta 143761 aaacagctgg taaaggtcac aaaggtcaaa acgctcgttc tggcggcggt gtacgccctg 143821 gattcgaggg gggacaaatg cctttattcc aacgtcttcc taaacgtggt ttcactaaca 143881 tcaaccgcaa ggaatacgct gtagtcaacc tagacaaatt gaacggtttt gcagaaggaa 143941 cggaagtcac tcctgaactt cttctagaga ctggtgttat tagcaaactt aatgcaggag 144001 taaagattct tggcaacggt aaattagaga aaaaattaac tgtaaaagcc aataaattct 144061 ctgcttctgc gaaagaagct gttgaagctg ctggcggtac agctgaggtg atctaacttg 144121 tttaaaacaa tctccaactt tatgcgtgtg agtgatatca ggaataaaat catattcact 144181 ttactcatgc ttatcgtctt tcgcataggt gcgtttattc ctgtgcctta cgttaacgct 144241 gaagcgttac aggcacagtc tcaaatgggt gtttttgatc tccttaatac atttggcggc 144301 ggtgcgcttt accaattttc cattttcgca atgggaatta ctccttatat cacggcttcg 144361 atcatcattc agctgcttca gatggatgtg gtaccgaagt ttaccgagtg gtctaagcaa 144421 ggtgaagttg gccgccgtaa attagctcag ttcacaaggt actttacgat tgtgcttggt 144481 ttcatccaag cgttaggtat gtcatatgga ttcaacaatc tggcaaacgg tatgctgatc 144541 gaaaaatccg gtgtatcgac atatcttatc attgctttag tgctcactgg cggaactgcc 144601 tttttaatgt ggcttgggga acaaattact tctcatggag taggcaacgg aatatcgatc 144661 attatcttcg cggggattgt gtctagtatt ccaaaaacaa ttgggcaaat atatgagact 144721 caatttgtcg gcagcaacga tcagttgttt attcatattg tgaaagtcgc acttcttgtg 144781 attgcgattt tagcagttat tgttggagtt attttcattc agcaagccgt acggaaaatt 144841 gcgattcaat atgctaaagg cacaggtcgt tcacctgctg gcggaggtca gtctacacac 144901 cttccattga aagtgaatcc tgcaggggtt attccggtaa tctttgcggt tgcgtttttg 144961 ataacgccgc ggacgatcgc gtcattcttt ggaacaaacg atgtgacaaa gtggattcaa 145021 aacaactttg ataatacgca tccggtgggt atggcgatat atgttgcgtt gattattgcc 145081 tttacgtact tttatgcttt tgtacaggta aaccctgaac aaatggctga taaccttaaa 145141 aaacagggtg gctatatccc gggggttcgt ccagggaaaa tgactcaaga tagaattacg 145201 agcattttgt atcgacttac gtttgtgggt tctatattct tagccgtgat ttccattctt 145261 cctatctttt tcattcaatt cgctggattg cctcaaagtg cacaaattgg cggaacatct 145321 ttgttaattg ttgtcggggt agccttggag acaatgaaac aactagaaag ccagttggtg 145381 aaacgaaact accgtggatt tatgaaaaac tagaggaaat ggatttatcc attccctctt 145441 aataaagaga ggacggggga aatccgaatg aacttagtct taatggggct tcctggtgcc 145501 ggtaaaggca cacagggcga acgaattgtt gaggattatg ggattcctca tatctcaaca 145561 ggagatatgt tccgtgctgc tatgaaagaa gaaacaccac tcggactcga agcaaaatct 145621 tatattgata agggagagct cgtacctgac gaagtcacaa tcggaattgt aaaagagaga 145681 cttggcaaag atgattgtga aagaggtttt cttctggacg gatttccgcg aacagtcgct 145741 caagccgaag ctcttgaaga aattcttgag gaatacggca agccgattga ttatgtcatt 145801 aacattgaag tcgacaaaga tgttctgatg gaacgtctga ctggacgcag aatttgcagt 145861 gtttgcggca caacctatca tttagtcttt aatccgccga aaacgccggg tatttgtgat 145921 aaagacggag gcgaactcta tcaacgggca gatgataatg aggaaacagt ctctaaacgg 145981 cttgaggtaa acatgaagca aactcagcct ttactcgatt tctattcaga gaaaggttat 146041 cttgcaaacg tgaatggcca gcaggacatt caagacgttt atgcagatgt gaaggatctt 146101 cttggaggat taaaaaaatg attatctgta aaaccccacg tgaacttggt atcatgcggg 146161 aagcagggcg aatcgtggct ttaactcatg aagagttaaa aaagcacatt aaaccaggaa 146221 tctcgacaaa agaattggat caaattgccg aacgttttat taagaagcag ggtgcaatcc 146281 catcttttaa ggggtataat gggtttcgcg ggagcatttg cgtatcagtt aatgaagaac 146341 tcgttcacgg catacctggc agcagggtgc tgaaggacgg tgacatcatc agtattgata 146401 tcggtgctaa attaaatggt tatcatggtg actctgcatg gacatatccg gtaggaaaca 146461 tcagcgatga tgacaaaaaa cttctggaag tgacagagga gtctttatat aaaggcttgc 146521 aggaagcaaa accaggtgaa cgtttgtcga atatttccca cgcaatacaa acgtatgtcg 146581 aaaatgagca gttttcagtt gttagggagt atgtcggaca tggtgttggt caagacttgc 146641 atgaggaccc gcaaattcct cattacggtc cgcccaacaa aggaccacgg cttaaacctg 146701 gcatggttct cgctattgaa cctatggtga acgctggcag ccgctacgtg aaaacattgg 146761 ctgataactg gacggttgta acggtagatg ggaaaaagtg tgctcatttt gaacatacga 146821 ttgcgattac ggaaacgggt tttgatatac tgacgagagt ctagatgatg aaaataattc 146881 cgaagacaga tgtttttcaa gcttgatagg gcagaaagct tgggtgaaca ttggcaagac 146941 cgaattcatc ttgcttcttg tcgttggaat tttaaccatc atcaatgtac taacagcaga 147001 cggagaaaag cgtacatttc attctcctaa gaaaaagaat atcaatcatt taacccttta 147061 tgattgcgta tctccggaag ttcagaacag tataaacgaa acagggcgtg tgacaaactt 147121 cttttgaaat ttgtcagaaa gcaagttact gatttgaaga agggagaaca cttgaatggc 147181 gaaagacgat gtaattgaag tggaaggtac tatagtcgaa acactgccaa acgcgatgtt 147241 caaagttgaa cttgaaaatg gccacactgt tttggctcat gtatctggta aaatccgcat 147301 gcacttcatt cgcattttac ctggagacaa agttacggta gaattatctc catatgactt 147361 aactcgtggc aggattacgt accgttacaa ataaagcact ccggaaactg aaggaggttg 147421 gaaacacatg aaagtgagac catcagttaa accaatctgc gaaaaatgta aagttattcg 147481 cagaaaagga aaagtaatgg tgatctgtga aaatccaaag cataaacaaa aacaaggata 147541 atttataagg aggtgcccag agaatggctc gtattgctgg tgtagatatc ccacgtgaca 147601 aacgtgttgt tatttcttta acatacatct tcggaattgg ccgcacaacg gctcagcaag 147661 ttttaaaaga agctggagtt tcagaagata ctcgtgtgcg cgatcttact gaagaagaac 147721 ttggtaaaat ccgtgatatt attgacaaac tgaaagtaga aggtgacctt cgccgtgaag 147781 tttctcttaa tatcaaacgt ctgatcgaaa tcggaagcta ccgcggaatc cgtcatcgca 147841 gaggattacc tgttcgcgga caaaactcta aaaacaacgc gcgtactcgt aaaggtccgc 147901 gtcgtactgt agctaacaag aaaaaataag taagggaggt tcttaaacaa tggctgctgc 147961 tcgtaaatct aacacgcgta aacgtcgcgt gaaaaagaat attgagtctg gaattgctca 148021 tattcgttca actttcaata acacgatcgt tacgatcact gacactcatg gtaatgctat 148081 ttcttggtct agtgccggag ctttaggatt cagaggttct cgtaaatcta ctccttttgc 148141 tgcgcaaatg gctgcagaaa cagctgctaa aggttcaatc gaacatggtc ttaaaactct 148201 agaggttact gttaaaggac ctggttcagg ccgtgaagct gcaatccgtg cacttcaagc 148261 tgctggacta gaagtcactg ctatcagaga cgtaactcct gttcctcata acggatgccg 148321 tccaccaaaa cgtcgccgcg tgtaatttgt ttgtatagat tttgtgtccc tgtcaataat 148381 gggttatgat acagttattt atgaaacgaa tgcaccgact cgttgcctga gcacatacgg 148441 gactaaacaa tggggaattt cggatggaat ctcatatgat tctattcgag gtttcgacgt 148501 tttgaaggag ggttttaagt aatgatcgag attgaaaaac caaaaatcga aacggttgaa 148561 atcagcgacg atgccaaatt tggtaagttt gtcgtagagc cacttgagcg tggatatggt 148621 acaactctgg gtaactcctt acgtcgtatc ctcttatcct cactccctgg tgccgctgta 148681 acatcaatcc agatagatgg tgtactgcac gaattctcga caattgaagg cgttgtggaa 148741 gatgttacaa cgattatctt acacattaaa aagcttgcat tgaaaatcta ctctgatgaa 148801 gagaagacgc tagaaattga tgtacagggt gaaggaactg taacggcagc tgatattaca 148861 cacgatagtg atgtagagat cttaaatcct gatcttcata tcgcgactct tggtgagaat 148921 gcgagtttcc gagttcgcct tactgctcaa agaggacgtg ggtatacgcc tgctgacgca 148981 aacaagagag acgatcagcc aatcggcgtg attccgatcg attctatcta tacgccagtt 149041 tctcgtgtat cttatcaggt agagaacact cgtgtaggcc aagttgcaaa ctatgataaa 149101 cttacacttg atgtttggac tgatggaagc actggaccga aagaagcaat tgcgcttggt 149161 tcaaagattt taactgaaca ccttaatata ttcgttggtt taactgacga agctcaacat 149221 gctgaaatca tggttgaaaa agaagaagat caaaaagaga aagttcttga aatgacaatt 149281 gaagaattgg atctttctgt tcgttcttac aactgcttaa agcgtgcggg tattaacacg 149341 gttcaagagc ttgcgaacaa gacggaagaa gatatgatga aagttcgaaa tctaggacgc 149401 aaatcacttg aagaagtgaa agcgaaacta gaagaacttg gactcggact tcgcaaagac 149461 gattgactag tttcccttgt gaactaggat tttcgtgtgt ttattattca gaaacagcat 149521 tccaataaag gaggggacat cacatgtcat acagaaaact aggacgtacg agtgcacagc 149581 gtaaagctat gcttcgtgat cttacaactg atttgatcat caacgaaaga atcgaaacaa 149641 ctgaaacacg tgcgaaagaa cttcgctctg tagttgaaaa aatgatcacg cttggcaaac 149701 gcggtgatct tcacgctcgc cgtcaagctg ctgcatacat ccgcaacgag gttgcaaacg 149761 aagaaaataa tcaagatgca cttcaaaaat tattctctga cattgcaact cgttacgagg 149821 agcgccaagg tggatacaca cgtattatga agcttggtcc tcgccgtggt gacggagcac 149881 caatggcaat tatcgaattg gtttaatcac atatttttgt gtatctaaag aagggcggga 149941 cagtttctaa ctggatctat gccctttttt tagatactgc aacttttaat agagagaaaa 150001 gcagagcatt agctgagagg aggccggttt tccatgaatc aaaatcagtt gatatcggta 150061 gaggatatcg tatttcgata tcggaaggac gcagaaagac gagcactaga cggcgtctcc 150121 ctgcaggtgt atgagggtga atggcttgca atcgtaggtc ataacggttc agggaaatca 150181 acactggccc gggcattgaa tggtttaatt cttcctgaat caggcgacat tgaggttgcc 150241 gggattcaat tgacagagga atctgtttgg gaagtgcgta agaagatagg tatggtcttt 150301 caaaatccgg ataaccaatt tgtcggaacg actgttcgcg atgatgtggc ttttggttta 150361 gaaaacaatg gtgtaccgcg ggaagaaatg attgagagag tagactgggc agtaaaacag 150421 gtgaatatgc aagattttct cgatcaagag ccgcaccatc tctccggagg ccaaaagcag 150481 agagttgcga ttgcgggggt tattgccgca cgtcctgata ttattatctt agatgaagca 150541 acatccatgc ttgatccgat cgggcgagaa gaagtgcttg aaacggtaag acatttaaaa 150601 gagcagggca tggcgactgt catatccatt acacatgacc tgaatgaggc agcaaaagca 150661 gacaggatca ttgtcatgaa tggcggtaaa aaatatgctg aagggccgcc tgaagagatt 150721 tttaaattga ataaagaact tgttcgaatt gggcttgatt tacccttctc attccagctt 150781 agccagcttt taagagaaaa tggactggct ttggaagaaa accatttgac tcaggaaggg 150841 ctggtgaaag agctgtggac attacaatca aagatgtaga gcatcgctat cagatgaaga 150901 ccccgtttga gcgcctagca ctgtatgata tcaatgcatc gattaaagaa ggaagctacg 150961 tagccgttat cgggcataca ggctctggca agtccactct tctacagcac ctaaatggtc 151021 tcctgaagcc gacgaaggga cagatatcac taggcagcac tgtcattcag gcagggaaaa 151081 agaataaaga tctgaaaaaa cttcgtaaaa aagtcggaat cgttttccaa tttcctgagc 151141 atcaattatt cgaagaaaca gttcttaaag atatttcatt cggaccgatg aactttggtg 151201 ttaaaaaaga agatgctgaa caaaaagcga gagagatgct gcagcttgta ggtttatcag 151261 aagagctttt ggacaggtca ccctttgaat taagcggggg acaaatgcgc agagttgcaa 151321 ttgccggcgt acttgcaatg gaccctgaag tgcttgttct ggatgaaccg actgcaggat 151381 tggacccaag agggcgaaaa gagattatgg acatgtttta tgagcttcat caacgtggga 151441 acttgacgac gatccttgtg acacacagca tggaggatgc agctgcatac gctgatgaaa 151501 tgattgttat gcataaagga acgatacaag catcaggcag tccgcgtgat ctgtttttaa 151561 agggtgaaga gatggccggc tgggggctgg atcttcctga aacaataaaa ttccaaagac 151621 accttgaagc tgcactgggt gtgagattta atgagcctat gctcacaatc gaagatgccg 151681 ctgccgaaat ccgtgctctt tttcagggag agaagacttt atgatggaca gcatgattat 151741 cggcaagtat gtaccgggga cttcacttgt gcaccggctt gaccccagaa caaaactgat 151801 cacgatcttt ttatttgtct gcattgtatt cttagccaat aatgttcaga catatgcgtt 151861 gcttggttta tttacaattg gcgtcgtttc tttaacaaga gttcctttct cttttttaat 151921 gaaagggctg aagccaatca tctggattgt cctttttacg ttccttcttc acattcttat 151981 gacacatgaa ggaccgatta tctttcaaat aggttttttc aaagtctatg agggcggtct 152041 ggttcagggg atattcattt ctcttagatt cgtctatttg attttaatca caaccttatt 152101 aacgcttacg actacaccga ttgagattac cgatggaatg gagcagctgc tgaacccatt 152161 gaaaaaatta aagcttcctg ttcatgagct ggctcttatg atgtcaattt ctttacggtt 152221 tattccgaca ctgatggagg agacagataa gatcatgaag gctcagatgg cgcgaggcgt 152281 tgattttaca agcgggcctg tcaaagaaag agtgaaggct attgtcccgc ttcttgtccc 152341 gctcttcgtc agcgcattta aacgcgccga agagcttgcg gtggcaatgg aagcaagagg 152401 ctatcaaggc ggagaaggac gtacgaaata tagaaagctt gtatggacag gaaaagacac 152461 ttctgtcatt gtcagcttaa ttgtattagc tgctttgtta tttttcttaa gggcttagag 152521 gtgctgtatg agactgaaat gcacgatttc ttatgacgga catttgttta acggttatca 152581 ggttcagccg ggcaaaagaa cggttcagga tgaactggag aaggctttgg ctgtcctgca 152641 taagtcaaaa gacagaattc cggtcgtttc gtctggaaga acagacagcg gggttcacgc 152701 agccggacag gtgattcatt ttgacactcc gctgtctatc ccggctgaga gatggccata 152761 tgccttaaat gcactgcttc cggacgatat cgcagtcaaa caggcagaaa ttgcggatga 152821 tgggttccat gcacgattta gcgcagtcaa aaaagaatat cgctactttg tatacacgga 152881 gaaacacccg gacgtattta aacggcatta cgcttaccat ttttcatatc gccttaatgt 152941 gcaggacatg agagaagcgg caaagcatct tatagggaca catgatttta cgagcttttg 153001 cgcggctaaa acagaagtgc aggacaaggt aagaacgata tacgaacttg attggactga 153061 gacggctgac ggcctgcaaa tgcggatcac aggcagcggt ttcttatata atatggtcag 153121 aattattgcg ggtactttgc ttgatgcagg tattggaaaa atttctcccg atgaggtgaa 153181 atccatgctg gaagcgaagg atcgcgaagc ggcagggcgc acagcgccgg ggcacgggct 153241 atatttatgg aacgtttact atgacaacta aaccaggtgt ataatatttt cttgacagag 153301 tctgcataaa gttataagat atcatatggt atgtatttca accccacgat aagccccgga 153361 acttattgtg ttgtgaaata gaacgtaatc gaagtttatt gaaaatgaca gatcatttag 153421 gagggaaatt caatgcgtac aacacctatg gctaacgcaa gtactattga acgcaagtgg 153481 ttagttgttg atgctgctgg caagacttta ggtcgtcttt cttcagaagt tgcagctatc 153541 cttcgcggaa aacacaaacc aacttacaca ccacacgttg atactggaga tcatgtgatc 153601 atcatcaacg ctgaaaaaat cgagttaact ggtaaaaagt taactgacaa aatctactac 153661 cgtcacactc aacatccagg cggattaaaa tcaagaactg ctcttgaaat gcgtacaaac 153721 taccctgaga aaatgcttga gcttgctatc aaaggcatgc ttccaaaagg ttctctaggt 153781 cgtcaaatgt tcaaaaaatt gaacgtatac cgtggttctg agcatccaca cgaagcacaa 153841 aaacctgaag tttacgaact tcgcggttaa ttaaaaagga ggttaccaat ttggcacagg 153901 ttcaatatta cggtactggc cgtcgtaaaa gctctgtagc gcgtgtgcgt ttagttccag 153961 gagaaggccg tatcgtcgtt aataatcgtg aaatcagcga acatatccca tctgcagctt 154021 taatcgaaga tatcaaacaa ccattaactt tgactgaaac agctggcact tatgatgttt 154081 tagtaaacgt acatggaggc ggcctatctg gtcaagctgg agcaatccgt cacggtatcg 154141 ctcgtgcttt gcttgaagca gatccagaat accgtacaac tcttaaacgt gcaggtcttc 154201 tgactcgtga cgctcgtatg aaagaacgta aaaaatacgg tcttaaaggc gctcgtcgtg 154261 cacctcagtt ctcaaaacgt taattttacg ttttcaaaaa gctctcgacc ttgggttggg 154321 agcttttttc tttcaataaa acgtggcagt cccgcataaa aataacaact gaatggacgc 154381 ttgacggggt taagcaaatt gtttgtttat aaacggtctc tttgtaataa tcatggtaga 154441 tttcattctt attcaattgg aagttcggtc aatgtttatt atcgttatgt gatcagccca 154501 gctccatcta accactgtat ctcatccgtt aaagttcact gctgattctt aacccggaga 154561 aacaatagct ctcattgcta atggctttat gtaacgaagt aaaagtaaat ctgatgatat 154621 aaatcacata tctcctttgt gatttttttg cgtttttatg aacttttttc taaatatgca 154681 aagggaaagc gatatcaatc tagaaatatt tgttatactc tatacattaa agtaaggaga 154741 agattcatga atgcgttagt agctcataat agcaaagcct gggataaaaa agtagaaaca 154801 ggcaatgaat ggactgttgc tgttgaacag caggttatcg aacaagcaaa aaaaggcaat 154861 tgggatataa gggtaacacc aatgaaagat gtaccgaagg attggtttcc gcctatcaaa 154921 ggtctgaaag tactctgttt agcatcaggc ggcggccagc agggtccagt tttggcagcc 154981 gcaggcgcgg atgtcactgt attagataac tcagaaaaac agctgaatca ggatagaatg 155041 attgctgagc gagatggtct gacgatacac actgtcaaag gaagcatgga cgatttaagt 155101 gtatttaatg atgaatcatt tgatgtcatt gtacatcctg ttgccaatgt ttttgttgag 155161 aatgtcctcc cggtatggaa ggaagcgtac cgtgtgttga aaaggaacgg cattctaatc 155221 tcgggttttg tcaatcctgt tgtatttctg tttgatacag aattagaaca gcaaggtgtt 155281 ttaaaagtaa aacactctat tccatacgct gacccagaag atcttccgaa acataaagtg 155341 aaaaaactga tcgaaaataa tgaggctctg gaattcggcc attccttaga agaccaaatc 155401 aaaggccaaa ttgatgccgg ttttatcgtt actggttttt atgaagataa aggcggtttt 155461 gtattagacc aatatatcca tacatattct gcaacaagaa gcgtgaaagt atgaaaagca 155521 gcgacctgtt agaggggctg cttttttcat aaccaattac agaacatttg ttcctcaccc 155581 tgcagaaagc tgatttttta tcaatgttac accttcattt gggcgaattt ccaaccgaat 155641 tcgggcattg tttcatcatc caaacctcaa aataatcggt aaaaggagag tgaatttata 155701 tggcagaagt actgtctttt atggatgtga aacgccaaaa ggattttgaa ttagaaaaga 155761 acttgctcaa agaactctct ctgagacaaa ttatccagtc tgttaaggat tgtttggaac 155821 cattatttcc atttttacat gatgaacgag atattattac cgaaggctgt attgattttg 155881 cgattgaagc ttatttgtta ggcgggcgtt ttgggatatt cggctattac ggagaatcaa 155941 tgcagagtat cagtgcccgc tctgcaagag aagaagaaga gctgcgtatg gagttttttg 156001 attatctcta taattggata cacgagcaat acgcaacatt tgataaaaac actgtttatg 156061 aagcggcacg caagttcatt aaagattggt ggacagcagg gtttgttcaa agagaaaaac 156121 agtgtaagct tcgcatgcgg taatcatatt tcccgaccct gtcccatagt tatgtaataa 156181 cggacaagcg ggaggggaag ggatgaggaa aaagcttaaa tggctcagtt ttttgctagg 156241 cttcatcata ttactatttc tgttcaagta tcagttcagc aataacgact cttggaagcc 156301 gtggagcctg cccttgagcg gtaaaatcat ttatctagat ccaggtcatg gcgggcctga 156361 cggcggagca gtcggcggaa agctgttaga gaaggatgtt accctggaag tggcctttag 156421 agtcagggat tatcttcaag aacaaggagc gcttgttatc atgaccagag aaagtgatac 156481 tgatctcgct ccagaaggaa caaaaggcta tagccgacga aaagctgagg atctaagaca 156541 acgagtcaaa ttaataaacc attcagaggc ggagctctat atcagcattc atcttaatgc 156601 gattccgtca caaaaatgga gcggagccca aagcttttat tacgggaaat atgcggaaaa 156661 tgagaaagtc gcaaaataca ttcaggatga gctgagaaga aatctggaaa acacaacccg 156721 gaaagcaaag cggattcatg gtatctactt aatgcaaaac gtcaccaaac cgggggcgct 156781 tatagaagtc ggatttttat ccaatccaag tgaagcaacg ttgctcggta aaccgaaata 156841 tcaagacaag gtggcatctt ccatatataa aggcattttg cgatatttca cagaaaaagg 156901 agaccctccg gagtaatgga gggttttctt gtggttctaa gcataagaca cccgccattt 156961 atgtatgata taataataat tgtaaacgaa tacacaaaag ggtgaggttc gatgataaga 157021 gaagatgaag taagaaaact agtcggagaa atgcgcgaac cttttcttca aagacctctg 157081 ggagaattgg atgccgttaa ggaaattaaa ataaagcctg aaaaacggca tatcagtgta 157141 aaagtcgctc ttgcaaaaac aggaactgca gaacaaatgc agattcagca agagatcgta 157201 aacgtattaa aaggggcagg agctgagaca gtcggccttc gatttgaaga gctgcctgaa 157261 gaaacggttg ctaaattccg ggcgccgtca gctgagaaaa aaacattatt aaatatggat 157321 aacccgccag tctttcttgc tgtagcaagt ggaaaaggcg gcgtaggcaa gtcaactgtg 157381 tcagtaaacc tagctatttc tctggctcgt ctagggaaaa aggttggttt aattgatgcg 157441 gatatttatg ggttcagtgt gccggacatg atgggtatca ctgtgcgtcc aacaattgaa 157501 ggagagaaac ttcttcctgt tgaacgcttt ggagtaaagg tcatgtcaat gggctttttc 157561 gtagaagaaa atgccccggt cgtatggaga gggccgatgc tcggcaaaat gctgaataat 157621 tttttccatg aagtagagtg gggagaagta gactatatcg ttcttgatct tccgcctggt 157681 acaggggacg ttgctctcga tgtacataca atgcttccga gctgcaaaga aattatcgta 157741 tctacgccac atccgacagc tgcttttgtc gcggccagag cgggctctat ggcgattaaa 157801 accgatcatg aggtcgtggg tgtcatagag aacatggctt attatgaaag tgcaaagaca 157861 ggggaaagag aatatgtgtt tggaaaaggc ggaggagata aactggctga ggaactaaac 157921 gtgcctttgc tcggcagaat cccattgaaa cagcccgatt gggataagga ccaatttgct 157981 ccgtctgttt atgacgaaaa tcatccaatc ggagaaatat atcaggacat cgcaaaaaaa 158041 atagatgcaa aaatgtcagt gcaggtataa aaggtgaacc gggattccag atcccggctt 158101 tccctttatt cactttcttt tgctgtgtct tttgctgctt ttttcagctc atcttcgaac 158161 tgctttttgt aaagcggact agaaagtgtt tcgttaataa cctcttctaa ataactgcgg 158221 aattcttggc tttttgccag ctggctgtac tttttatcca tgccgggatc ctgcataacg 158281 ctcatcagca tcttctggta atctggatcc ttcatcagct ttttaatcac tttttcatgc 158341 tctgtctgaa gagttttggc aaagccctca gcaaaatcag tgtcttcaaa gatgtttttc 158401 caaaattctt cacctttttt agatgtgagt gttttttcta ttgttccttt aattgcatct 158461 tggtcaatca ccagcgcttc attcatggca tcatcattta ataattcctt aatagctttc 158521 tttccatcat cagtttttaa tatatcaaca accatttttt tggtctgatc atagtccata 158581 tccgctgctt ggtcttttgg agcgcaagct gttacagata ataacaaaaa acagctcatc 158641 aatagcgttt tggcttttga catgcttaag ctcctttcac atacttgtct tacctttaat 158701 atgattcatc tgtttggaat tatacataac aaaatatcgc tgttcgcgat ttttgagggg 158761 atgaataaag aaatgaaaag ccgtggttta gttcgttttt tcttttctat tttagctgtc 158821 ggggcgctta tcacgagtat tgtgggtttt gctttaaagt ggggagaata tagagggctg 158881 tttctaacat ttgaagcggg acagattttc tctgttttat tttggtttat cggtgtaggc 158941 atgattttca gtgtgatcag ccaaatgggt tttttcgtgt ttttaacagt tcatcggttt 159001 gcgcttgaga tattaaggtc ctcctctttg tggaatttgc tgcagttgtt tttcatcctg 159061 tttgttgctt ttgatttaat gtacgtgcgt tttttatttt ttggagagag cggagaatcg 159121 ctggctggct atgcgtggtt accggtgttt ttattgatct ttggagtgat tacagcttat 159181 ataaagcaaa agcagtcctc taagaaaaca tttgtgtcat cgttattttt gatggttgtg 159241 attaccgcat tagaatggtt ccctgcatta agagtaaatg atgaggactg gctttattta 159301 atgctttttc cgttaatggc atgtaatgcc ttccaattgc tgatgctgcc gaagtttgca 159361 gcaaagtaat tactttacct ctgcggattt ggcatcagaa tttgcgatga gatcacccac 159421 ggttacattt tttaatcctt tttctttcag ctgatggatg atatcaggca atgcttcttc 159481 tgtttgtttt gcagaatcgg aggcatgtaa aagaataatg tctccaccgg aaacttgctt 159541 ggtcacattg tcgatgattt tttcaactcc gggatttgtc cagtcttgag agttcacact 159601 gtaatgaacg actgtataat tgtattgctt tgcgaccttt agaacattct tattgaattg 159661 gccggtaggg ggtcttaata gctgtatgtc tttgacccct aacttttcaa aggctgtttg 159721 cgcacggttc atgtcctttt ttatttcgct gctctctaaa ttggcatagt ttttataagc 159781 gtagcccatg ctcccgattt gatggccgtc ctttacgata cgggccactg tgtcgggatg 159841 gcgttctgcc caagaagcgg acaggaaaaa cgttgcgttt ttaatcccgt ttgctttcag 159901 agtattaagt atcggttctg ctctctcatc accccagctg atatcgaaag taagtgaaat 159961 atctttagag tctgtttctc ctttataaat ggctttaggt ccggtgtcag ttgaaaacac 160021 gggaagcggg acagctcttt ggatataaaa aaagctggca gctgcaaatg cggcgataag 160081 tataataatt aattgtttta cccgtttaat gtgccacaca tagaagtgat tcactgatga 160141 tgcctcctta tcttgtccat cattcttgtt ttacatctta tgagcatgga caattgaata 160201 taaccgataa aatgtctctt cacatacagc ctaaattggg tgttgacctt ttgataatat 160261 ccgtgatata ttattattcg tcgctgataa acagctgaca tcaactaaaa gcttcattaa 160321 atactttgaa aaaagttgtt gacttaaaag aagctaaatg ttatagtaat aaagctgctt 160381 cgttaagcgg cagtaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca 160441 tttttataaa tcgcacagcg atgtgcgtag tcagtcaaac tactttatcg gagagtttga 160501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cggacagatg 160561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 160621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 160681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 160741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 160801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 160861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 160921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 160981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 161041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 161101 gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc agaagaggag 161161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 161221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 161281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 161341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 161401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 161461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 161521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 161581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 161641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 161701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 161761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 161821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 161881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 161941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 162001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 162061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 162121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaagtaa tacaagatat 162181 cacatagtga ttctttttaa cggttaagtt agaaagggcg cacggtggat gccttggcac 162241 taggagccga tgaaggacgg gacgaacacc gatatgcttc ggggagctgt aagcaagctt 162301 tgatccggag atttccgaat ggggaaaccc accactcgta atggagtggt atccatatct 162361 gaattcatag gatatgagaa ggcagacccg gggaactgaa acatctaagt acccggagga 162421 agagaaagca aatgcgattc cctgagtagc ggcgagcgaa acgggattag cccaaaccaa 162481 gaggcttgcc tcttggggtt gtaggacact ctgtacggag ttacaaagga acgaggtaga 162541 tgaagaggtc tggaaaggcc cgccatagga ggtaacagcc ctgtagtcaa aacttcgttc 162601 tctcctgagt ggatcctgag tacggcggaa cacgtgaaat tccgtcggaa tccgggagga 162661 ccatctccca aggctaaata ctccctagtg accgatagtg aaccagtacc gtgagggaaa 162721 ggtgaaaagc accccggaag gggagtgaaa gagatcctga aaccgtgtgc ctacaagtag 162781 tcagagcccg ttaacgggtg atggcgtgcc ttttgtagaa tgaaccggcg agttacgatc 162841 tcgtgcaagg ttaagcagaa gatgcggagc cgcagcgaaa gcgagtctga atagggcgca 162901 tgagtacgtg gtcgtagacc cgaaaccagg tgatctaccc atgtccaggg tgaagttcag 162961 gtaacactga atggaggccc gaacccacgc acgttgaaaa gtgcggggat gaggtgtggg 163021 taggggtgaa atgccaatcg aacctggaga tagctggttc tctccgaaat agctttaggg 163081 ctagcctcaa ggtaagagtc ttggaggtag agcactgatt ggactagggg cccctaccgg 163141 gttaccgaat tcagtcaaac tccgaatgcc aatgacttat ccttgggagt cagactgcga 163201 gtgataagat ccgtagtcga aagggaaaca gcccagaccg ccagctaagg tcccaaagta 163261 tacgttaagt ggaaaaggat gtggagttgc ttagacaacc aggatgttgg cttagaagca 163321 gccaccattt aaagagtgcg taatagctca ctggtcgagt gactctgcgc cgaaaatgta 163381 ccggggctaa acgtatcacc gaagctgcgg actgttcttc gaacagtggt aggagagcgt 163441 tctaagggct gtgaagccag accggaagga ctggtggagc gcttagaagt gagaatgccg 163501 gtatgagtag cgaaagaggg gtgagaatcc cctccaccga atgcctaagg tttcctgagg 163561 aaggctcgtc cgctcagggt tagtcgggac ctaagccgag gccgaaaggc gtaggcgatg 163621 gacaacaggt tgatattcct gtaccacctc ctcaccattt gagcaatggg gggacgcagg 163681 aggatagggt aagcgcggta ttggatatcc gcgtccaagc agttaggctg ggaaataggc 163741 aaatccgttt cccataaggc tgagctgtga tggcgagcga aatatagtag cgaagttcct 163801 gattccacac tgccaagaaa agcctctagc gaggtgagag gtgcccgtac cgcaaaccga 163861 cacaggtagg cgaggagaga atcctaaggt gatcgagaga actctcgtta aggaactcgg 163921 caaaatgacc ccgtaacttc gggagaaggg gtgctctgtt agggtgcaag cccgagagag 163981 ccgcagtgaa taggcccagg cgactgttta gcaaaaacac aggtctctgc gaagccgtaa 164041 ggcgaagtat aggggctgac gcctgcccgg tgctggaagg ttaagaggag cgcttagcgt 164101 aagcgaaggt gcgaattgaa gccccagtaa acggcggccg taactataac ggtcctaagg 164161 tagcgaaatt ccttgtcggg taagttccga cccgcacgaa aggcgcaacg atctgggcac 164221 tgtctcaacg agagactcgg tgaaattata gtacctgtga agatgcaggt tacccgcgac 164281 aggacggaaa gaccccgtgg agctttactg cagcctgata ttgaatgttg gtacagcttg 164341 tacaggatag gtaggagcct tggaaaccgg agcgccagct tcggtggagg catcggtggg 164401 atactaccct ggctgtattg accttctaac ccgccgccct tatcgggcgg ggagacagtg 164461 tcaggtgggc agtttgactg gggcggtcgc ctcctaaaag gtaacggagg cgcccaaagg 164521 ttccctcaga atggttggaa atcattcgca gagtgtaaag gcacaaggga gcttgactgc 164581 gagacctaca agtcgagcag ggacgaaagt cgggcttagt gatccggtgg ttccgcatgg 164641 aagggccatc gctcaacgga taaaagctac cccggggata acaggcttat ctcccccaag 164701 agtccacatc gacggggagg tttggcacct cgatgtcggc tcatcgcatc ctggggctgt 164761 agtcggtccc aagggttggg ctgttcgccc attaaagcgg tacgcgagct gggttcagaa 164821 cgtcgtgaga cagttcggtc cctatccgtc gcgggcgcag gaaatttgag aggagctgtc 164881 cttagtacga gaggaccggg atggacgcac cgctggtgta ccagttgttc tgccaagggc 164941 atcgctgggt agctatgtgc ggacgggata agtgctgaaa gcatctaagc atgaagcccc 165001 cctcaagatg agatttccca ttccgcaagg aagtaagatc cctgaaagat gatcaggttg 165061 ataggtctga ggtggaagtg tggcgacaca tggagctgac agatactaat cgatcgagga 165121 cttaaccata tttttgaatg atgtcacatc tgttatctag ttttgagaga acactctcaa 165181 tttgtttggt ggcgatagcg aagaggtcac acccgttccc ataccgaaca cggaagttaa 165241 gctcttcagc gccgatggta gtcgggggtt tccccctgtg agagtaggac gccgccaagc 165301 agatttatta attctaccat gtttgtttat gaagctttat attattccgc agtagctcag 165361 tggtagagct atcggctgtt aaccgatcgg tcgtaggttc gaatcctacc tgcggagcca 165421 ttgcttccat agctcagcag gtagagcact tccatggtaa ggaagaggtc agcggttcga 165481 gcccgcttgg aagcttaaat gtattattac caaggtttct cataaggaga aagctttttt 165541 tattgcgata tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 165601 gggttcgaat cccgtcttcc gctccattta tcctaacggg atattgtaaa ttgaattgcg 165661 cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg gttcgactcc 165721 tctcgggcgc gccatatctt ttaatagaat agataggaaa tcgggaagta gctcagcttg 165781 gtagagcaca tggtttggga ccatggggtc gcaggttcga atcctgtctt cccgaccatt 165841 ttttatgggg ccttagctca gctgggagag cgcctgcttt gcacgcagga ggtcagcggt 165901 tcgatcccgc taggctccac caaaagtttt taaaaaagtt attgactttg aagaagtgac 165961 attgtatact aataaagttg ctttaacaaa gcggacaaac aaaatgatct ttgaaaacta 166021 aacaagacaa aacgtacctg ttaattcagt ttttaaaaat cgcacagcga tgtgcgtagt 166081 cagtcaaact actttatcgg agagtttgat cctggctcag gacgaacgct ggcggcgtgc 166141 ctaatacatg caagtcgagc ggacagatgg gagcttgctc cctgatgtta gcggcggacg 166201 ggtgagtaac acgtgggtaa cctgcctgta agactgggat aactccggga aaccggggct 166261 aataccggat ggttgtttga accgcatggt tcaaacataa aaggtggctt cggctaccac 166321 ttacagatgg acccgcggcg cattagctag ttggtgaggt aacggctcac caaggcaacg 166381 atgcgtagcc gacctgagag ggtgatcggc cacactggga ctgagacacg gcccagactc 166441 ctacgggagg cagcagtagg gaatcttccg caatggacga aagtctgacg gagcaacgcc 166501 gcgtgagtga tgaaggtttt cggatcgtaa agctctgttg ttagggaaga acaagtaccg 166561 ttcgaatagg gcggtacctt gacggtacct aaccagaaag ccacggctaa ctacgtgcca 166621 gcagccgcgg taatacgtag gtggcaagcg ttgtccggaa ttattgggcg taaagggctc 166681 gcaggcggtt tcttaagtct gatgtgaaag cccccggctc aaccggggag ggtcattgga 166741 aactggggaa cttgagtgca gaagaggaga gtggaattcc acgtgtagcg gtgaaatgcg 166801 tagagatgtg gaggaacacc agtggcgaag gcgactctct ggtctgtaac tgacgctgag 166861 gagcgaaagc gtggggagcg aacaggatta gataccctgg tagtccacgc cgtaaacgat 166921 gagtgctaag tgttaggggg tttccgcccc ttagtgctgc agctaacgca ttaagcactc 166981 cgcctgggga gtacggtcgc aagactgaaa ctcaaaggaa ttgacggggg cccgcacaag 167041 cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaggt cttgacatcc 167101 tctgacaatc ctagagatag gacgtcccct tcgggggcag agtgacaggt ggtgcatggt 167161 tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccttgat 167221 cttagttgcc agcattcagt tgggcactct aaggtgactg ccggtgacaa accggaggaa 167281 ggtggggatg acgtcaaatc atcatgcccc ttatgacctg ggctacacac gtgctacaat 167341 ggacagaaca aagggcagcg aaaccgcgag gttaagccaa tcccacaaat ctgttctcag 167401 ttcggatcgc agtctgcaac tcgactgcgt gaagctggaa tcgctagtaa tcgcggatca 167461 gcatgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca ccacgagagt 167521 ttgtaacacc cgaagtcggt gaggtaacct tttaggagcc agccgccgaa ggtgggacag 167581 atgattgggg tgaagtcgta acaaggtagc cgtatcggaa ggtgcggctg gatcacctcc 167641 tttctaagga tattatacgg aatataagac cttgggtctt ataaacagaa cgttccctgt 167701 cttgtttagt tttgaaggat cattccttcg aaacgtgttc tttgaaaact agataacagt 167761 agacatcaca ttcaagtaat acaagatatc acatagtgat tctttttaac ggttaagtta 167821 gaaagggcgc acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg 167881 atatgcttcg gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca 167941 ccactcgtaa tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg 168001 ggaactgaaa catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg 168061 gcgagcgaaa cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc 168121 tgtacggagt tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag 168181 gtaacagccc tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac 168241 acgtgaaatt ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga 168301 ccgatagtga accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag 168361 agatcctgaa accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct 168421 tttgtagaat gaaccggcga gttacgatct cgtgcaaggt taagcagaag atgcggagcc 168481 gcagcgaaag cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt 168541 gatctaccca tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca 168601 cgttgaaaag tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat 168661 agctggttct ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga 168721 gcactgattg gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca 168781 atgacttatc cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag 168841 cccagaccgc cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct 168901 tagacaacca ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac 168961 tggtcgagtg actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga 169021 ctgttcttcg aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac 169081 tggtggagcg cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc 169141 ctccaccgaa tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc 169201 taagccgagg ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc 169261 tcaccatttg agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg 169321 cgtccaagca gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat 169381 ggcgagcgaa atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg 169441 aggtgagagg tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg 169501 atcgagagaa ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg 169561 tgctctgtta gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag 169621 caaaaacaca ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt 169681 gctggaaggt taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa 169741 cggcggccgt aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac 169801 ccgcacgaaa ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag 169861 tacctgtgaa gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc 169921 agcctgatat tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga 169981 gcgccagctt cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc 170041 cgccgccctt atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc 170101 tcctaaaagg taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag 170161 agtgtaaagg cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc 170221 gggcttagtg atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc 170281 ccggggataa caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc 170341 gatgtcggct catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca 170401 ttaaagcggt acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg 170461 cgggcgcagg aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc 170521 gctggtgtac cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa 170581 gtgctgaaag catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga 170641 agtaagatcc ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat 170701 ggagctgaca gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct 170761 gttatctagt tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca 170821 cccgttccca taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt 170881 ccccctgtga gagtaggacg ccgccaagca attgcacatt agtgtaattt tttaaaaaag 170941 ttattgactt tgaagaagtg acattgtata ctaataaagt tgctttaaca aagcggacaa 171001 acaaaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca gtttttaaaa 171061 atcgcacagc gatgtgcgta gtcagtcaaa ctactttatc ggagagtttg atcctggctc 171121 aggacgaacg ctggcggcgt gcctaataca tgcaagtcga gcggacagat gggagcttgc 171181 tccctgatgt tagcggcgga cgggtgagta acacgtgggt aacctgcctg taagactggg 171241 ataactccgg gaaaccgggg ctaataccgg atggttgttt gaaccgcatg gttcaaacat 171301 aaaaggtggc ttcggctacc acttacagat ggacccgcgg cgcattagct agttggtgag 171361 gtaacggctc accaaggcaa cgatgcgtag ccgacctgag agggtgatcg gccacactgg 171421 gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc cgcaatggac 171481 gaaagtctga cggagcaacg ccgcgtgagt gatgaaggtt ttcggatcgt aaagctctgt 171541 tgttagggaa gaacaagtac cgttcgaata gggcggtacc ttgacggtac ctaaccagaa 171601 agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag cgttgtccgg 171661 aattattggg cgtaaagggc tcgcaggcgg tttcttaagt ctgatgtgaa agcccccggc 171721 tcaaccgggg agggtcattg gaaactgggg aacttgagtg cagaagagga gagtggaatt 171781 ccacgtgtag cggtgaaatg cgtagagatg tggaggaaca ccagtggcga aggcgactct 171841 ctggtctgta actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 171901 ggtagtccac gccgtaaacg atgagtgcta agtgttaggg ggtttccgcc ccttagtgct 171961 gcagctaacg cattaagcac tccgcctggg gagtacggtc gcaagactga aactcaaagg 172021 aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 172081 accttaccag gtcttgacat cctctgacaa tcctagagat aggacgtccc cttcgggggc 172141 agagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 172201 cgcaacgagc gcaacccttg atcttagttg ccagcattca gttgggcact ctaaggtgac 172261 tgccggtgac aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc 172321 tgggctacac acgtgctaca atggacagaa caaagggcag cgaaaccgcg aggttaagcc 172381 aatcccacaa atctgttctc agttcggatc gcagtctgca actcgactgc gtgaagctgg 172441 aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc cttgtacaca 172501 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cttttaggag 172561 ccagccgccg aaggtgggac agatgattgg ggtgaagtcg taacaaggta gccgtatcgg 172621 aaggtgcggc tggatcacct cctttctaag gatattatac ggaatataag accttgggtc 172681 ttataaacag aacgttccct gtcttgttta gttttgaagg atcattcctt cgaaacgtgt 172741 tctttgaaaa ctagataaca gtagacatca cattcaagta atacaagata tcacatagtg 172801 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 172861 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 172921 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 172981 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 173041 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 173101 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 173161 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 173221 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 173281 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 173341 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 173401 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat ctcgtgcaag 173461 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 173521 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 173581 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 173641 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 173701 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 173761 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 173821 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 173881 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 173941 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 174001 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 174061 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 174121 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 174181 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 174241 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 174301 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 174361 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 174421 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 174481 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 174541 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 174601 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 174661 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 174721 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 174781 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 174841 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 174901 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 174961 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 175021 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 175081 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 175141 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 175201 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 175261 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 175321 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 175381 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 175441 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 175501 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 175561 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 175621 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 175681 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 175741 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 175801 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 175861 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag caagcttaaa 175921 cccagctcat tgagctgggt tttttgtttt atatctgtgc cgatttgctt tcgtcagtat 175981 ccattttatc aagcttctgc tttttaaagt tttctaatac ttttgaattc caatacaatc 176041 cctagcatga tcaacatgag agtcataaat aatcaaaatg cagtttgtac gggagactca 176101 tccagactcc atccgactgc gattggcagg atagagccgc caatccattg gcagcgaaca 176161 gcatgcttgt cgtttgttct gtttttccat gataaaattg attggtgaca ataaaataat 176221 ggcgaacatg ccggccataa ataagtccta agaaaaaact aagaataatc cctgcaaaag 176281 ctgttttatt gattgccaaa atacagagtt aaatgaggcc gctcatattt atcagcctga 176341 gataatgatg ataggttatt ttttcggaaa ccagctcggg ttgccaaatg agagaaaaga 176401 tattactgtc attaaaacga ttcttggttt catccggata tgataaaatg tctcagacta 176461 tatttgagcc atttttttct tcagcaatca tcttgcgtaa ttgataaaaa tttattatga 176521 tactctttgt atgacaactc cttgcctcaa tacaatatac tcaacgtttc cccgttttct 176581 ccggtcgttt ttcttttcat tttctcccgt aaaataaaaa aagctcccaa tacaatagat 176641 atggtgcgga tttatttttt actaaaaagg agtcgttata tttgaataat agttttacat 176701 taaaacagca atggttcggg aatatccgaa aagacattct tgctggcatt ttagttgcgt 176761 tagcgttaat acctgaagcg attggctttt ctattatagc cggtgtggat ccgatggtcg 176821 gtctttatgc gtcattttgc atagccatta ttatttctat ttttggtggc agacctggca 176881 tgatttcagc tgcgacaggc tcaatggcag tcgttatggt gtcgctggtt gctgatcatg 176941 ggcttcagta tttatttgcg gctacgattt tgacaggcat tattcaggtg attttaggta 177001 tcagtaaaat tgcaagatta atgaaattca tcccgcgttc tgtgatgatc gggtttgtga 177061 atgcgctggc gatccttatc ttctctgcgc agcttcccca gtttgaaggt gcttcttgga 177121 gcatgtatgc gatgcttgcc gggtcgttgg ttattattta tgtgctgcca aggtttacga 177181 ctgctgttcc gtctccgctt gtggcgatta ttgtgatgac aattattgcg gtcactttcc 177241 atgtggatgt gcggacggtt ggtgatatgg gcaatatttc tagttcattg cctcatttct 177301 taatccctga tgttccgttt acctttgaaa cactgcaaat tatttttcct tattcaattg 177361 ctttagcgtt tgtcgggttg cttgaatctt tgctgacagc acagattatt gatgaaatga 177421 cggatacgga tagtgataaa aataaagaga gccgcggaca gggaattgcg aatatcgtga 177481 ctggattctt tggcggaatg gcaggctgcg ctatgatcgg acaatctgtc attaatacaa 177541 aagcgggcgg tcgcggacgt ttgtcagcat ttgttgccgg tgcttttctg atgtttttaa 177601 ttgcggtgtt aagtcatgtc gtggtgaaaa tcccaatggc ggcgttagta gctgtaatgg 177661 ttatggtgtc tgtcggcact tttgattggt cttctttaaa aggtctcaaa aaagcgccgc 177721 tcacggactc gattgtcatg gttgtgactg tggttacggt tgttgtgacg gatgacttat 177781 ctaagggtgt atttgtcggt gttcttttaa gtgccgtgtt ctttgtagca aaaatctcga 177841 agctgaaaat cgtttctcat gcagaggatc aaaagcttag aacgtatcaa gtgaaggggc 177901 aaatcttttt tgcgtcagtg actgatctta cgaatgcgtt tatatatcaa gaggatattg 177961 agcgggttgt gattgactta actgaagctc acgtatggga cgattctggt gcggccgcac 178021 ttgataagat tgttgcgaag tttaaggaac aaggcattga agctgagtta aaaggtttga 178081 ataaagcgag taaatctcta atgaaacaga tggcataaaa tagagaagcc cagatgaatg 178141 agatctgggc ttttttatat aacatacact taagcagcat tgatataata gagagaagag 178201 aaattttaaa taggggactt gcatatgatg cttcagaagc tgaaccgtgt attggggaga 178261 gtgatgccgc tgttaacgcc gactagtgtg gtgctgggcg tgctgctgtc tcagttttta 178321 aatgggtatg aatgggctgt gccttggatc tttgctttta ttacgtttgc aggcagtttg 178381 agcgcgaact ttcaatcttt gagacatgca ttgtctcatc ctctccctat gattcttgca 178441 ctattcgttc ttcatatttt catgccgctt tttgcttggg gcagcggcca tcttatattt 178501 aaaggtgatc ctttgacgat taccggttta acattggctg ttgtgattcc tacggggatt 178561 acaagcttga tttgggcagc gatgtacaaa gggaatgtcg gtttgacact ttcgattatt 178621 ttagttgata ctgtgctgtc accgctaatc gtaccgctga gtctttcatt gctggccggc 178681 gctcaggttc acatggatgt gtggggaatg atgaaaggtc tgattgtaat ggtcgtgatt 178741 ccttcttttt tgggcatgct gtttaatcag atgtcatctc cagaaagaac tgcgtttgtg 178801 agcagtgcgc tgtcgccttt ttcaaagctt tgcttgatgg cagtgattgc gattaacagt 178861 tcagcgattg ctccttattt caaatccatt gatttgagat ttgcaggaat agctgtaacg 178921 gtattcttta tcgcgttaac aggttatgcc gctgcttggc tgatcggaaa aatgatgaaa 178981 aggcggcaag aggaaatagt ctctcttata tttacgggag gcatgaggaa tattagtgcc 179041 ggcgcagttc ttgccgttac gttcttcccg tctcaggttg ccgttcctgt tgtgatcggc 179101 atgctgtttc agcagatatt ggctgctttg tttggctata tgctgaatcg ttttgaatta 179161 aaaccaatgt tgcagaaggc ataaaaaaac cgctcatagg gttgagcggt tttttccgta 179221 tagccattcg agcgcgttga tgaactgttt gcagaaatac ttgtggtggt gcaccgctcc 179281 tttttcaatt gaaagacaca actggtcttc agtgaagcct ttttctttta gactttgatg 179341 aacttgcttt gtttttttca gcatatgtcg ctgaatggat tgtttttcac ggccttcttc 179401 actcccgata gacatgaaaa cacgtgcagt gccgggcttt aaagaagata tatgaatggt 179461 ttccgctgcg ttctcgtacc agtatgaacc tgatatagag cctattttcc cgaacattga 179521 cggatatttt aatatggcga acattgagat gaggccgcct aatgaggcac cgatcattcc 179581 tcttgactgc ggttccctgg tgacgttcca gttttcttcg attagcggaa tgaactggtt 179641 cgttatatca gacagatagt gatatcccat tccgccgaag tccgtgaacc gatcactgag 179701 tgatgcagcc ggccatgggg tgtattcatc aagccggttt tcgggttcga taccgatcag 179761 cacgagttca gggagccttt gctgttgaaa ggcgctttct agtaattcga tttggttttg 179821 gaacaaagaa ctgccatcct gcacgtaaac agcaggaaat cccccgctgt ctgtgctgta 179881 ggaaggaggg aggtacagcg tgaacctcct gttgccggct ttgtgttctg aaagagatcc 179941 tttcaagcat tctccccctt tttttgcttg aaaagcagat ataagaaata aggaactccg 180001 aggatcgcca aaatgatgcc tgcgggcact tctgcgggct gaaaaaacag ttttccggca 180061 aagtctgcgc ttatcacaag aagcatcccg attaaaccgc tcagtggcag gatatagcga 180121 tgttcgacgc cagccagtct ccgtgagata tggggagcaa ttaagccgac aaacgccata 180181 cttcccgcta cggagacaca ggcgctgatg attgctacac aggcaacgag aaggatggtt 180241 ttttctttat ttgatgaaat accgaggctt ctgactgtgt cttcatcaaa acgaatggtg 180301 tcgagcaggc gggatttgcc gataagaatc ggtataaaca gcagcatcca tgggagtaca 180361 gctgtaatat acgtccagtt ggcagaccag atgcttccgt ttttccacac catggccatt 180421 tgatagtctt gcgggtccat ttttaaagat aaaaacaaag acagggcgct gaatcctgaa 180481 ttgatcgcaa tccctaccaa aataattctt cctgaatcta aattgcctct gtgccatgca 180541 aatatgtaaa tcaggatcgc cgcgatgagc ccgcctatca atccaaagag cggcattccc 180601 atcgctgcag ctatggatgt cacttccttc tggccttgga ataagagcat aaacgctaca 180661 atgccagctc ctgcccctgc gttgattccg agaattccag ggtcagcaag cccgtttctc 180721 gtgatggcct ggataacagc gcctgcaatg ccaagaccga gtccaataat agcagccatg 180781 acaacccgcg gcagtcttaa atcgaacagc aaaatttcat actgcggatt cgggtcgatt 180841 tgaaaaagag tggagagcag ctcagcagga cgaacagaaa atgatccgct cgttaagctg 180901 aaatagctga caacaagaat caaagcgatg aacaatgcat attttttagc cattttgctc 180961 ccctcctttt cgtttaatta aataaaggaa gaaaggtacg ccgataatgg atgttacgac 181021 ctcaatcggt gtttcaaacg gatagttgat aaatctgctt gcgagatcac acagggttaa 181081 aaagattccg cccaaaatac aggaacacgg aatcagcctg ctgtaatcag agccgacgag 181141 aaatctcgtg atatgcggaa caaccaaccc gacaaacgca atttttccgg ccagcgctac 181201 ggcactgccg gttagaatga tgacggaaag catcgccatg attttaatgg tttttttctt 181261 ttgccccagg cttttagaaa tgtcgtcccc taatgataca gcggttacct ttttgctgag 181321 agaaatggcc attataatgc caatcaggaa aaacggagcg gcaagcttca ggaaatctgg 181381 actcatttga tgaagtctgg cactgtacca gaaactgaga tcctgagaaa tttgaaaata 181441 aatcgacatg gccgctgata agctgctgag cagcatgctt gtgactgtgc cgatgatggc 181501 gagctgcacg ggggtaaatc cgtttggcat catggcggca aggccgaata ctaacaccgc 181561 tcctaacgct gagccgataa aagagtatat catcatttca atcgaagatg attgcgggag 181621 cagaaccatg caaagcgtaa tgataaacgc tgaaccatct gaaacaccca taatggatgg 181681 cgaagctaaa taattgcgcg taatgccctg cataagcgct ccagaaacag caagggctgc 181741 ccctatgagc agagcgccgg cagcccttgg aatccgggaa tgccatataa tttgatggtc 181801 tgtgtttccc ggatcgaaat gaataagaga tgtaaaaaca atatctgtgc tgagatgctt 181861 tgccccataa aggattgaaa gcaaaagtga cagcgctata gcaaatggag aagtaatcaa 181921 tatgatacgt gtccactgtt ttgaatacat acaaaaacct actctgaatt agttttgtgt 181981 caatttttca gcagccgctt tcaggaaacg gactttgctc caagctgtgc cgccttgtgc 182041 gagagggtcc actgagttga catacacatg gtcttctttg actgctttaa ggcttttcca 182101 gattggattt ttctctaaat cttttaaggc atcaggtttg tctgcatttt catcatcaga 182161 aaattggacg aaaatatggt ccgggttcat ttcacttaat ttttctaatg aactcagctc 182221 ttgcgctttt gcagccttta cttcgttcgg cgccttaagg cctaaatcac cgtatagtgt 182281 ggagttgaaa tacacctgtt cagggtaaat gtaaatgttg ccttgtctga ttctgatgac 182341 aagcgctttt gaatctttcg ctttatcgtt gatttttgtt tttatttctt ttagatcctg 182401 ttcatagtct gcaataattt tctttgcttt tttctctttt ccagtcagct gggcaagaag 182461 catcatgttt tccttccagt ttgaagagat atgagaaact gggatcgtcg tgcctgctgt 182521 gctgattttt tgcagcgttt tttccggaaa ctttgttgaa gcaaggataa catctggctt 182581 catttcaaga atcttttcaa tatttggctc cattttttct ccggttggtt cggctttatc 182641 agtgatgtct ttgaacatat cagggaattt gccggagaat gaaattgcgc cttgcggatg 182701 aacgtcaagc aatttcgcgt cttccattga ttcaacgctt cccgtaatgg caattttgtc 182761 tgtcggtaca gttacttcat atgttttatc aaggtattca attttcttct tctcagatgc 182821 tgtgccgctt gccttgctgg cagttgattc atttttgctg ccgcaagctg ccgccgtcag 182881 cgcgagaagt aagattaata aggtaagaga tatctttttc atctatagag cctcctgttc 182941 aattgataac tattatcaat tggaattata gagaatgaac agatataaca ccatggacaa 183001 attcctgatt tatcatggac aatctccgga tagtaaagaa acagtttgct gaacgatgcg 183061 ttcgtgcccg caagctgagt attcattcca cgggtcaagg gatagaagat aaacacggtt 183121 atctcgtacc gcgcttaggt tttgccatgc ttctgtctgc tgtaattgct ggtagtaagc 183181 tatggtctcc ggctctttaa aaagaaaaag catcatacag tcagcttggt aatttgcgat 183241 attttctaac gaaatcgctt gttctgaagg tgtgtcagcc gttgttgccg agctgaatcc 183301 taaatcccca aagaaaactt cgcggacact tcggttatga gccagataga agttttgctt 183361 atgcagcctc aaaaagagaa aacgcagccc ttgaacgtgc tgaagtgttt ttttggcggc 183421 cgttgtctgc tggtcataat ccgctagcca cttttctgct tcggactcct cctttaaaaa 183481 tgaggcagtt tgcagaaagt gggttctcca gctttcttct gaaggaaggt acatgacttc 183541 tgcgatgcga ttcaggcgat cttgttcttc tggagaaata gaatccatgc tgacaatcac 183601 atctggttct gcctgtgata acgtgtacag gttttcttcc cacttttcat taaaccggta 183661 tgcactgagc tggacgggta tatctgtcga ataatgctga tagtagtaag acgtccattt 183721 cggatgcaga gcggccgcaa aaggtatgtg gtgaagaggg atgagatggc ccattgtgcc 183781 ccttccgtat gcggcgattt tctttcggcg ttttttcata tagcttgtag gtgaacagcc 183841 tgtatatttt ttaaagattc tgctgaaata aaattcatct tgataaccgg tttggtgtgc 183901 gatttctttc aatttgcagt ttgattttgc catgagccgt tttgcctttg tgattcgtgt 183961 tttcgtaata aattctgtta cgctctgtcc tgtccatttt ttaaagcttt cactgtagtg 184021 tttggcactg attcctgcca tttgcgacag ctgggcaagc gtgatttttg tatcggcatg 184081 ggtttcgata tagtgttttg ttttttcgat tgctgaatgt gtatccgttt gatcagataa 184141 actggcagta aaaagatcat aaatcaggct ttgtacttca atcacacatt ttagctgaga 184201 aagctgagac gattcattcc atagtgcggc aagctcttga agccggactg caagattttc 184261 gatatgtgaa acattcataa gcttcagttt ggctaattcc gattctgtgc acggtgtgaa 184321 aatatcttgc ccggtttcct tgatatagct tagaagcctg attatacagg catctatatg 184381 tccatcggct gctggcgtaa agccaaaggt ctcgttaggc ggacaaacat aaagtgtctt 184441 tttttgcaga ggattggtgt ttgttccgat cgaaatatag ccgtttcctt ttaaatgaaa 184501 aatcagcacg aatgaatcgg ctaattgctg ttctgagaag agatcacttg tcttttttag 184561 atattcaatt tgtactggtt gataaatcac tgcattttgc acgagtagac caccttttca 184621 gaagctttca attgataatc attttcaata aaaattgtac caaataaatg aaagttttcc 184681 tatataaagc gggtgggttt ttagcatgaa aaaaaccctt acttatgtgt aaaagtaagg 184741 gtctttcgtt caataagaat atgttacacg tgtaacatac gatgcttatg ttctaataaa 184801 tgagatactt ttttcttgtt ttgctgaatt gttggagtgt tttttcatag ctgtttatga 184861 tgttctcaac cgaagttcca ttttcaattt ttgtcctgat ccagccgttg cctgccagtt 184921 tatcgaatga acctgttgac aggaactcaa aatcctcagg atagagatcg tgtatggttt 184981 taatgactga aagacccgtt ttaacggctt caaacttatc tctgtctgtc acatagagct 185041 gcacaccgtg gcaaagcgtt ccttgatgtt tagaaaacgt cggtgtgaag gatgctgccc 185101 taaatgtaac gcccggcaaa tggaggctgt ttaatgtttc ttcaagttct gtgcttttga 185161 taaagggagc tccgatcaat tcgaatggct ttgttgtccc tcgcccttcg gatatatttg 185221 ttccttcaat cagcccggtt gcaggataaa caaatgtgct ttccaccgtc ggcatgttag 185281 gcgaagggag gacgaaaggc aatcgggtat cgtcaaaatc catttttcgt ttccagtgtt 185341 tcatttttac cactgtaaga tcggcatcaa tactaaattc tttgttgaac agtgaagcca 185401 attcgcctat cgtcatccca tgcttcaatg gaatgggata caatccgaca aatgaggcgt 185461 attcaggttc taagattggt ccttcaatat gattcccgcc ttgaggattc ggacggtcca 185521 gcaccataaa tggaatgccg ttttctttag cggcttccat tgcgtatgcc attgtataaa 185581 tgtacgtgta gaaacgggtc ccgacatcct gaatgtcaaa cattagaata tcgacatttt 185641 taagcatttc tggagtcggt tttttcgttt ttccgtagag gctgtatacg ggaaccccgg 185701 ttttttcgtc aatgtaagag cctacttcgt ctccagcctg ggcgtcaccg cggacgccgt 185761 gttcagggcc gaataaagct gtcagtttga tatccgggtt ctcgtaaagg atatcgacac 185821 tgctttttag agatgtgttt actccggctg gattggtgat cagtccgatg cgttttccct 185881 tgagctgttt tttatagtct ggcaagagcg tgtctatccc agtctggact ttaggttttt 185941 tagctgtttg attctttgaa tcgggtgaag cagaggcagc ggttatcgtt ccgaacatca 186001 tgagccctgt cagaaaagcg aatattgttt ttctcatgtg tccctcctta ttaaagcggt 186061 cttcccgttt tgatatttaa tccgtagcca agtgggtaaa gggtgttccc tggtttcgtg 186121 actgacggaa tgtcaactgg aagtgtgcct ttaggttttg cctggccgaa tatcgccatc 186181 actccggccg gaatattagg ttgaagataa cggccatttg cgtatccttt aaagccatag 186241 actgcaatca gtgcttttgc ttcttcgaaa ttggctgcgt cataggggtt gcgcaggctc 186301 attaagacaa atggtttgtt gtgctgcagt gcggctttca tgacagctct cggaaacacg 186361 gtggcccatt tgcttgaatc tgatattgtg tcgtcgatga caccgtcgtt gacgacaggg 186421 tcatttttga cgacatagga gccggtaatg atataatcag cctcttttac ttgtttttca 186481 tgctcggtct taaatacttg gctggcaaag ttcattttgc tgagggatac gggtttgatt 186541 ttctttcgct tgatgagatc gtgaatggtt tgttcgattg aagcagtttg ttcttcgtaa 186601 ggtgccacaa ttaagattcg gctgcctttt ttaggcttga acggcaaagt gtgctgttca 186661 ttttttaata cagttactgc tttttcagct aattttttct ctgctttcag gtgctgcttg 186721 cttcctacga tttttttggc tttggctatt ttttcttttg tactgtcgct gtttcgcgct 186781 ggatacatgc cgcgttttat tttcagggaa atgattcttt caactgaatt gttgatttgt 186841 tgttcaggaa tatccccgtt tttcacggct tctttcaaag cttgaataac acgtgcgaat 186901 ttctgttctt ctttcaatga agtgactgag gctggcatta atgcaatatc gacaccagct 186961 tttacggcca tgaccacagc ctcttcctgt ccgaaatgat ctgcgattgc cttcatattg 187021 agcgcatcgg taacgatgac cccattaaag cccatttcct gacgaagaag acctgtcatc 187081 actttttttg aaagtgtagc tggaaccaga atgtccgatc catcgagttt gcttttgtaa 187141 gtggtgtcat caaaggcggg aaactgaaca tgggctgtca tcaccatatc agcaccagca 187201 tcaattgctt tttgaaaagg ataaagctcg acctcacgaa gccgttcttg gccatgggaa 187261 acgagcggca gtccataatg gctgtcaacg tccgtgtctc catgtcccgg gaaatgtttg 187321 agggcagacg cgatatcctg ccgctgcaac cctttcatcg tatataaacc gaggcgtgat 187381 gtcagttctc gattggagct gaatgaccgt acgccgatta caggattatc aggattattg 187441 ttaatgtcca cgacagggct gaaatctgta ttgatgccta aggcagagag ctcttttccg 187501 atgatgctgc cggtctgata cgcattgatt ctgcttctgg ctgcgcccag cgccatattc 187561 cctgggaaat tagtgccctc ccctaacctc gttacaatgc cgccttcctg atcaatactc 187621 agcatgagcg ggatttttgg acttgccttt tggtaatcgt ctgtcagttg gacagtttgt 187681 tttgttgttt ttacattttc tgcaaaaagg atgatgcctc cgaattgata tttcttgacg 187741 aggctggcga cttcatcatt catttttgta agggcttgcg gagaggactc gccttccttt 187801 tgccaatttc taaaatcagg catcagcatc tggccgagtt tttcatctaa cgacatacga 187861 ttgacaatct gattggcatc gattgcacgt ttggatgcag aggcttctgt ctgtctggcc 187921 ccgaaaaagc atgaaagaaa gagaacggct gaaaggataa gcggaaagac aggtctcata 187981 gaaacttcct cctatcgtct aatcattcac tccatcgctt cataaatcgc ggttatgaca 188041 cttccataac tgcctgttgg aaattggtca ccttcaaaga cgttcggatt ttcttccgga 188101 tcaataactg gtgtatgctt tttatttgtt aacaatgcga tgcctaaatt gtatgctgga 188161 tcaataattg taactgtccc cgtccagccg gtatgcccgt aagcattttc gctggcatga 188221 gggccaaaca tccattccat gcttttactt ccgttccgcc tccagccaag agcgaatgtc 188281 ggatctgttg ctgaaggtgc tgtaaacagg tcggctgttt tctgatcaaa taaagaaatg 188341 tttcggtatg aacctttgtt taacatgact tgcagcagta tggccatatc atctgcattt 188401 gagaacaatc cggcatgccc agacacgccg tccattgagt aaaacgcttt ttcgtcatgc 188461 acctctcctt gcagcgtgtt tgtgcggatg ttagggaatt gaataacgcc gtcacgtgta 188521 ttgcccatgc gttcagtagc tgcgaactgt ttcggtttaa agcccttttg cagcggattg 188581 tacaaggtat gcttcagcct gagcggtttg tagagctctt gctccgtgta gacatcaagc 188641 ggtttgccgg tgagtttttc gacaatacat ccgagtagca tatatccaat gtcactgtat 188701 acgtgttttg tcccggtttg ataatcgagc ggaattttcg tcaaatattc aatcgttttg 188761 tcccgttctt gggaatagta cttgccggct ttttccggcg tgtaaaagta aaagcttgat 188821 gggagccctg attggtgctg gaggacatca atgacacgta tcttgtcttt tccttttatg 188881 aggtcacccg gctgatcctt gaaacccggc aaatatgcag aaactttttc atagacgtca 188941 agttttcctt ggctgactaa gcgctgcaat gcaaaatttg ttgcgtacat ttttgtattt 189001 gaggctaagt caaacatcgt gcgggttttc attttggccg gacggcgcag cagttctgat 189061 ccttcgtact ttttactgta gccgtatgct gcttttttta tgatgcgtcc atccttcacc 189121 accacaagaa cggcgcctgg aaatcctgct gcaatatccc gttctatcat ctgatctacc 189181 ttccttagct tcttcgtcga gaattgtgca gtttctgcat ttatgatttt cggctcaatc 189241 aagttgcctg ctgtttgtgc gaaggtttca tttggcgcaa atatcgatag ggttaaaatg 189301 gcactgaata tgaacagtgt ctttgttttc acaggctagc ccctttctgt gcttctatcc 189361 cgtttactat ccctaaaaca gaaacaattt aatcgaactg agaagccatt tcatctttat 189421 atccgaatgc ataggtcaat aaaaaaccgg ccgcgtagga aataaagagc ccaacgatat 189481 acaggatgat ttgcgaaggc aggactagaa aagatagcgg cagtccggag acaccaatcg 189541 caatggtggc tacttgaaaa taagcttgaa aggcgccgcc gattccagct cctaaacatg 189601 ctgttaaaaa cggacggcca agcggcagcg tgactccgaa aataagcggt tcaccaatgc 189661 cgagcagtcc cgatggaagc ccgccggcga ttgctttcct cagtgttgtt tttttcgtct 189721 tcacgaaaac ggcaaaggcc gcgcctacct gtcctgcacc tcccatagcc aaaataggga 189781 gcagaggatc attgccaatt gaattgatca gttccatgtg cacaggcgtc aagccttgat 189841 gcagtccggt tacgacgaga ggaaggaagg ttgcgcccag aataaagccc gcagcgatgc 189901 cgccgatgtc caggatggac agtaggccgg atgtaatagc atcagaaatg aatccgccta 189961 aaggcataaa tacgacatac gttacgattc cggtgattaa cagtgaaacg gtgggtgtga 190021 caatgatatc aagtgattga ggaataaaac ggcgaataaa ttgttcggtg taagcaatga 190081 atatggctgc gaaaaggacg ccgatcagac ctcccctgcc cgggagaagc tcttctccaa 190141 ataaactgat ttttgcgatc tccggattga taatcaagat cccggccaaa gccccaagtg 190201 cgggtgtccc gccaaattct ttcgaagcgt taataccgac gagaatgccg agataagtga 190261 acagccctga tccgatgact gtcaggataa tcgcaatttg tgagtctgca gagagccagc 190321 ctgcttgaat aattgctttg gtaatcccag taattaaacc ggaagcgact agagcgggaa 190381 taagagggat aaaaatgctg gcaattttac gtaagaaaag tttaaaagga gtggcatttt 190441 tccgattgat atcggctttc tttttggccg ctgcttcttt gacatcggca ccttcttctg 190501 ctgacacgag ctttgagaaa gcagctgtaa catgattgac aactcctgtg ccgaggataa 190561 tttgtaaggt ttcagcttca acgaccccca atacgccgtc aagctttctt aaagcctgag 190621 catccgcttt gctttcatcg taaggcgtaa tgcgcaggcg tgtcatgcaa tgcgtatatg 190681 aagaaatatt ggattttcct ccgcatagct caaggatttt ctgtgcgaga tgatggtagt 190741 tattttcttt gctcattaaa acccctcccc ttcaagatgc cttattttat tctcatagat 190801 tgtatggctg ctctcgtttt atctatataa ccggttgtcg tttcatactg ctcagccgcc 190861 atgcctaaaa acaaaacatc aattataaaa agctgggcga ggcgggaaga agtggctgca 190921 cttcgaatca aggcttcatt ggaatgggct gtatacaaag ggacatcagc cagtgcggag 190981 acggatgtct gactgaattg tgtgaggctg atcgttgtga tgcctttttc cttagccatg 191041 gcgaacagtt caacgatttc ctgtgtctct cctgaaaacg aaatggcgaa tacgatgtcg 191101 tctttatctg catttgcgat taaagatgcc acaagatgag tgtctgtaaa cgcggttgct 191161 tgtttatgaa tgcgaagcca cttttgctgg gcgtccttgg cgacaatgcc ggaagccccg 191221 aggccgataa aatgcacggt atgagctttg agaagcagag aaaccgctcg ttcaagctct 191281 ttgtagtcca tcaggtctga agtatcctga atggcttgaa tggcattgcc ggccgttttt 191341 tcggaaatgg agggcagcgg ctcgtgggga acaatatccc ggtagccctg aaacgtaggc 191401 tttgccagat cgcctgctac tctcattttt aaatcttgaa atccttttaa accgagtgat 191461 ttgcagagcc tgatgacggc agcgtcactt gaattggcta aggcgctgat ttcgttgacc 191521 gtgctttcga ttgctttgtg gggatgggct aggatataat ctgcaagttt gcgctcggat 191581 ggagggagct tatgcttcat tgattggatg atcgctaaac cgcctgtggc cattctagtt 191641 ctctccttat catggatggt aatgttcgat tgctttgtca atgaaaccgt ttgcttcatc 191701 gagtaatgtc tgtgcttgtt tctgatctgt gcttgttttg agcatgacga ttgctgtttt 191761 gacgtgatga tcggcttgtt ccagagtgta tctggctgtg tcgtatgaag cgtttgtaag 191821 gctttggatg atgctgatgg cgcgttcttt tagttttttg ttgctgacgt tgacgtctac 191881 catcaagttt tcgtaaacct tgccgatttt gaccattaca gcggtagata tcatgtttag 191941 aatcatttta tgagcggttg cggctttcat acgtgttgat cctgtaatgg cctcaggtcc 192001 gacgacaacc tcaatgctgt gatccgcatc cttgctgatg gcggaatttt cattgcaagt 192061 aagggcgatg gtgtgtgctc cgactttacg ggcgtatctt agggcgcctg cggcgtaggg 192121 tgtgcggccg cttgctgcga tggcaatgac ggtgtcattt gaagtgagct gtatgtttct 192181 taaatcttca gctcctgctt cttcactgtc ttcaatgccc tctgctgcct gtaaaaaggc 192241 ttcggggcct ccagccatga ttccgatgac ctgatctggg cttacgctgt aggtgggagg 192301 acattcaaca gcatccatga cgccgagtct gccgcttgtg ccggcgcctg tatatatgag 192361 ccggcctcca ttttgaaacg attcatatgc gcagtctaca gctgttttga tgtcggggag 192421 aacctcctga acggctgcag cgactttcat atcttcgttg ttgatcattt taaggatgcc 192481 gagagtgttt gctttgtgga tttcaactgt ttgactattg cgtgattccg ttgtaagacg 192541 gtgaaggttt aatggttctg acatgaggat gccccctgtt ttaaaatgat atatctcaat 192601 attcagtata ttcatttctg ttatgatatt tcaactatgt ttttaaattt ttgaaatttt 192661 atttcactta agactataag aaatgatgaa ggatcaactg ttctccaagc ggcccgattc 192721 ttcgccgtcc tttatcaagg aacccgcttt tcatataaag gtgttttgcg cgtatgttca 192781 gatgattgac ggccaagatg atttcgtcgc accatggaaa atatccgctc acaaaagcgg 192841 gaagcaaaag catggctttt ttcgcatagc cttttccgtg atgcacagcg gttaaagaca 192901 gggagctgag cagtaaagca aatggattgt tagaatagga agcaagcgtt tcttttgatg 192961 catgtaaaat gaaaaaaccg actggaaggt cgtcttttaa gatgacaacc gggtatcggt 193021 cctgtatgcc cagagcctga gacagcacct ctttcgggag ggaggtaaag cgtttgtcat 193081 cgttggtgag cgtgaatgat tggagctcgg gcaagtgttc aggcttatag aaggataaag 193141 aaatgtcttg agtcatgggg tggcctcctt acaatatgtc gttaagctcg ttttccgaaa 193201 tgacgcggta gcccgcttgt tttaacagtg cggcggttac tccgctgccg gtgatttttt 193261 tgccagagaa tgtgccgtta tagataaaac cgcttccgca agatggactg ttttctttta 193321 atatgacggc agaagcgttg atttcttttg cgtaagccaa tgttttcgcg gcgccttcca 193381 tatatagttc tgtgacgtct tctcctgaag ctgtcacgat tttcgctgtt ccattgagga 193441 catcctcgcc agtgcctcct atgatttctg cgggttcgcg tggggtagag aagccgccga 193501 gaagttcagg gcaagccatg actgctttct tttcatcgac tagttttctg attttctccg 193561 acgctgcgtg agagccgtta tatctgcatt caatgcctcc aaggcaagaa ctgactagaa 193621 tcatattggt ttctcctctc ttgctttgct tgtctctatc ataaaataaa tggctttagt 193681 tgggaggctt tttcagttaa aaaaggagtt aaaaagtttg aaaataaaaa atttaatttt 193741 cctctttaca aacagggggt gacctgtata taataacttt tgtcagctcg acgagaacac 193801 aacggcccgt tggtcaagcg gttaagacac cgccctttca cggcggtaac acgggttcga 193861 atcccgtacg ggtcaccatt tggaggatta gctcagctgg gagagcatct gccttacaag 193921 cagagggtcg gcggttcgag cccgtcatcc tccaccatct tgccggtgta gctcaattgg 193981 tagagcaact gacttgtaat cagtaggttg ggggttcaag tcctcttgcc ggcactgttt 194041 tttcaaaatt ttatgtggag gggtagcgaa gtggctaaac gcggcggact gtaaatccgc 194101 tccctcaggg ttcggcagtt cgaatctgcc cccctccacc attattgggc tatagccaag 194161 cggtaaggca acggactttg actccgtcat gcgttggttc gaatccagct agcccagtca 194221 cagacacctt tgatcaaaag gtgtcttttt tcttttcgga aaaatcattc caacttctaa 194281 ctgttcagtc tgtataataa ttttaaaaat atgttaaggt agtttattca cgaattacca 194341 tctacaccct gccaaaaatt tgataaactt attttataaa aaaattgaaa ccttttgaaa 194401 cgaagctcgt atacatacag accggtgaag gcagaggtta gataaatatg gaaatgatga 194461 ttaaaaaaag aattaaacaa gtcaaaaaag gcgaccagga tgcatttgcg gacatcgtag 194521 atatttacaa agataaaatt tatcagcttt gctaccgtat gcttggcaat gtgcatgagg 194581 cggaggatat tgcacaggaa gctttcatca gagcgtacgt taatatcgac agttttgata 194641 ttaaccggaa attttcaact tggctttatc gaatcgcgac caatttgacc attgaccgca 194701 ttcgcaaaaa gaagccggat tattacctcg acgcagaggt ggctggtacg gaaggcttga 194761 ccatgtattc tcaaatcgtc gcagatggtg ttttgcctga agatgcagtt gtatcgctgg 194821 agctctcaaa cacgatacag cagaaaattt taaagcttcc tgacaaatac agaacagtca 194881 tcgtattaaa gtatattgac gaactctcat taattgaaat cggggagatt ctaaacattc 194941 ctgtggggac tgtgaaaacg cggattcaca gaggcagaga ggctcttaga aaacaattaa 195001 gggatcttta agtggggtga tgaaatgagc tgtcctgaac aaattgtgca gcttatgcat 195061 atgcatcttg atggagatat ccttccaaaa gatgaacacg tattaaatga acatctggag 195121 acatgcgaga aatgcagaaa gcatttttac gagatggaga aatccatagc gctcgtacgg 195181 agcacatcgc atgtcgaagc ccccgcggat tttaccgcta atgtcatggc aaaattgcct 195241 aaggagaaga aaagagcttc tgtaaaaaga tggttcagaa cccatcccgt tatcgcagct 195301 gctgcggtat tcatcatttt gatgggcggg ggttttttta acagctggca taatgaccac 195361 aatttcagcg tgtccaagca gccgaatctt gtggttcata accatactgt gaccgtgcca 195421 gaaggtgaga cggtcaaagg tgatgtcact gtcaaaaacg gcaagctgat tattaaaggc 195481 aaaatagacg gggatgtaac cgtcgtaaac ggcgaaaagt atatggcctc tgctggacaa 195541 gtcaccggtc agattgaaga aatcaatcag ttattcgact ggacatggta caagatgaag 195601 tctgcgggga aaagtgtact cgatgcattc aatccgaacg gagaagagta aagcgcgtta 195661 gccgctttgc tctttttttg cgggctgaga gggctggcac atttcacttg ctaaatcgaa 195721 atgtggtata atgggctcgc tatgtaaagt acatatgcgt aacacgtaaa acacaaaata 195781 cgaaatgact gaaatcttgg aggacgagga aatggctttt gaggatatcc cttttttgca 195841 gtacctcggc aatgccgttg atattctcct tgtttggtat gtgatatata aattgattat 195901 ggtgatacgc ggcacgaaag cggttcagct gttaaaagga attgtagtca tcgtgcttgt 195961 tcgtatggcc agccaatatt tgggcctcag cacacttcaa tggctgatgg accaagcgat 196021 aacatgggga tttttagcaa ttattattat ttttcagcct gagctgagaa gagcgcttga 196081 acagctaggc cgcggccgct ttttttcgag gagcggcacg cctgttgaag aagcgcagca 196141 gaaaacgatt gaggccatta caaaagcaat caattatatg gcgaaacgcc gtataggcgc 196201 cctgctgacc attgagcggg atactggaat gggcgattat attgagaccg gcataccact 196261 aaatgccaaa gtcagctctg agctgctgat caatattttt attccaaaca ccccgcttca 196321 tgacggtgcg gtaattatga aaaataatga aattgccgcg gccgcctgtt atctgccgct 196381 ttctgagagc ccgtttattt caaaagaact gggcacgcgg cacagagcag ctgtcggtat 196441 cagtgaagta acagacagtt tgacgattat tgtgtctgaa gagaccggcg gcgtcagtgt 196501 ggcaaagaac ggcgaccttc acagagagct tacagaagaa gcgctgaaag aaatgcttga 196561 agccgagttt aagaaaaaca ccagagacac ttcttctaac cgctggtatt ggaggggcaa 196621 gaaaaatgga taaattctta aacaaccgct gggctgtgaa aattattgct ctgcttttcg 196681 cgctcttgct ttatgtggcg gttaacagca accaagcacc gactccaaaa aaaccgggtg 196741 aatctttctt tccgacatca acaactgatg aagcaactct gactgatatt ccggttaaag 196801 cgtattatga tgatgaaaat tacgtcgtga cgggtgttcc gcaaacggtt aatgtcacga 196861 taaaaggctc gacaagcgcc gtgaaaaagg ctcggcagac caaaaacttt gaaatatatg 196921 ccgatatgga acatttgaaa accggcacac ataaggttga gcttaaggcc aaaaacgtgt 196981 cggatgggct gacaatctca attaatccgt ctgttacgac agtgaccatt caggaacgga 197041 cgaccaaaag ttttcccgta gaagtggagt actacaacaa aagcaagatg aaaaaaggct 197101 attctccgga gcagccgatt gtcagtccga aaaatgtgca gattaccgga tcgaaaaatg 197161 tgatcgataa tatttctctt gtaaaagctt cagtgaattt ggaaaacgca gatgaaacga 197221 ttgaaaagga agcgaaagtg actgtctatg ataaagacgg aaacgcgctt cctgtcgacg 197281 tggagccctc ggtcatcaag attaccgttc cggtgacaag cccgagtaaa aaagtgccct 197341 ttaaaattga acggacagga agccttcctg acggtgtcag catagcgaat attgaatcca 197401 gccccagtga ggtaacggtt tacggctcac aggatgtgtt ggattctctt gaatttattg 197461 acggcgtcag cctagattta agtaaaatta acaaggattc cgatatcgag gcagatattc 197521 cgcttcctga cggtgtcaaa aaaatctcac cgtcaaaggt gactttgcat atagaagtcg 197581 atagtgaagc ggatcagaag ttcgagaatg tccctatcaa gactgtaggg ctgagcagct 197641 cacaaaacat tgaatttctt gatcctgaat cacaagcgat agatgtaacg gctaaaggct 197701 ctcccacgaa tataaataaa ctgaaaaaat cagatattga attgtatgtg aatgtttcag 197761 atttagagga cggggagcat agcgtgaagc ttgaagtgaa cgggccacag aatgtaactt 197821 ggtccttggg gcggaaaaac gccaaaatca agctgacgtc taagaaaagc aatacatcaa 197881 cgaatgataa cagcagcaat acatcaggga accaggacac agataaacaa acaaatgatc 197941 aaaagaacaa tcagcaagaa gatacaaaga acactgataa aaacaacaac gatcaaaacc 198001 aagacggaaa taaagatcaa aaccaagatc aggatgagga tgaatccact gcgaattcac 198061 aatcctcatc ggaataaaaa aggagcgatt ataaaatggg caagtatttt ggaacagacg 198121 gtgtaagagg tgtcgccaat agtgagctta cacctgagct ggcctttaaa gtcggacgtt 198181 tcggcggtta tgtgctgaca aaagacaaac aacgtccaaa agtgctgata ggccgcgata 198241 cacgcatctc cggccatatg ctggagggag cccttgtcgc cggactttta tccattggcg 198301 cagaagtcat gcgcctgggt gtcatttcta caccaggtgt atcttatttg acaaaagcga 198361 tggatgcaga ggcgggcgtc atgatttccg cttctcataa cccagtgcag gataacggca 198421 tcaaattctt tgggggagat ggatttaagc tttctgatga acaggaggct gaaattgagc 198481 gcctgatgga cgaacctgag gataagctgc caagacctgt cggagcagac cttggacttg 198541 taaacgatta ttttgaaggc ggacaaaaat atctgcaatt cttaaaacag acagctgatg 198601 aagatttcac aggcattcat gtggcattgg actgtgccaa tggcgcaacg tcatccttgg 198661 cgacacacct gtttgctgat ttagatgcag atgtttctac aatggggact tccccgaacg 198721 gattaaacat taatgacggc gtcggttcga ctcatcccga agcgctcagc gcgtttgtca 198781 aagagaaaaa cgcggatctc ggtcttgcgt tcgacggtga cggcgaccgc ctgattgctg 198841 tcgatgaaaa aggaaatatt gtagacggcg accaaatcat gtacatatgc tcaaaacatc 198901 tgaaatcaga gggccgttta aaggatgata cagtggtttc aaccgtgatg agcaacctcg 198961 gcttctataa ggcgctcgaa aaagaaggca tcaaaagcgt gcagacagct gtcggcgacc 199021 gctacgtagt agaagcaatg aaaaaagacg gctacaacgt cggcggagag cagtcaggac 199081 atcttatttt ccttgattac aacacgacag gggacggatt attgtctgct attatgctga 199141 tgaacacttt aaaagcaaca ggcaagccgc tgtcagagct tgcagctgaa atgcagaagt 199201 tcccgcagct gttagtcaat gtgagagtga ctgataaata taaagttgaa gaaaatgaaa 199261 aagtaaaagc agttatttct gaagttgaaa aagaaatgaa cggcgacggc cggattttgg 199321 tgcgcccttc aggaactgaa ccgctcgtcc gtgtcatggc tgaagcgaag acgaaagagc 199381 tgtgcgatga gtatgtcaat cgcattgttg aagtcgtccg gtcagaaatg ggattagagt 199441 aacgaagtct attatcagag agtgaacaag acaagcgagg tttacataag ataattgtga 199501 gacatacggc aaagttgctt aaaaaacaat tgaccgttta tgccacatgt tgtaaaatca 199561 agcttgtctt gttcttattt tctcaatagg aaaagaagac gggattattg ctttacctat 199621 aattatagcg cccgaactaa gcgcccggaa aaaggcttag ttgacgagga tggaggttat 199681 cgaattttcg gcggatgcct cccggctgag tgtgcagatc acagccgtaa ggatttcttc 199741 aaaccaaggg ggtgactcct tgaacaaaga gaaatcacat gatcttccaa aaaacatgta 199801 ggaggggacg attgaaagtc cccttgaaat ttgactttct tcgtctcctt ttacaatctt 199861 aggaggaaga aaaatatgtg tggaatcgta ggttatatcg gtcagcttga tgcgaaggaa 199921 attttattaa aagggttaga gaagcttgag tatcgcggtt atgactctgc tggtattgct 199981 gttgccaacg aacagggaat ccatgtgttc aaagaaaaag gacgcattgc agatcttcgt 200041 gaagttgtgg atgccaatgt agaagcgaaa gccggaattg ggcatactcg ctgggcgaca 200101 cacggcgaac caagctatct gaacgctcac ccgcatcaaa gcgcactggg ccgctttaca 200161 cttgttcaca acggcgtgat cgagaactat gttcagctga agcaagagta tttgcaagat 200221 gtagagctca aaagtgacac cgatacagaa gtagtcgttc aagtaatcga gcaattcgtc 200281 aatggaggac ttgagacaga agaagcgttc cgcaaaacac ttacactgtt aaaaggctct 200341 tatgcaattg ctttattcga taacgacaac agagaaacga tttttgtagc gaaaaacaaa 200401 agccctctat tagtaggtct tggagataca ttcaacgtcg tagcatctga tgcgatggcg 200461 atgcttcaag taaccaacga atacgtagag ctgatggata aagaaatggt tatcgtcact 200521 gatgaccaag ttgtcatcaa aaaccttgat ggtgacgtga ttacacgtgc gtcttatatt 200581 gctgagcttg atgccagtga tatcgaaaaa ggcacgtacc ctcactacat gttgaaagaa 200641 acggatgagc agcctgttgt tatgcgcaaa atcatccaaa cgtatcaaga tgaaaacggc 200701 aagctgtctg tgcctggcga tatcgctgcc gctgtagcgg aagcggaccg catctatatc 200761 attggctgcg gaacaagcta ccatgcagga cttgtcggta aacaatatat tgaaatgtgg 200821 gcaaacgtgc cggttgaagt gcatgtagcg agtgaattct cctacaacat gccgcttctg 200881 tctaagaaac cgctcttcat tttcctttct caaagcggag aaacagcaga cagccgcgcg 200941 gtactcgttc aagtcaaagc gctcggacac aaagccctga caatcacaaa cgtacctgga 201001 tcaacgcttt ctcgtgaagc tgactataca ttgctgcttc atgcaggccc tgagatcgct 201061 gttgcgtcaa cgaaagcata cactgcacaa atcgcagttc tggcggttct tgcttctgtg 201121 gctgctgaca aaaatggcat caatatcgga tttgacctcg tcaaagaact cggtatcgct 201181 gcaaacgcaa tggaagctct atgcgaccag aaagacgaaa tggaaatgat cgctcgtgaa 201241 tacctgactg tatccagaaa tgctttcttc atcggacgcg gccttgacta cttcgtatgt 201301 gtcgaaggcg cactgaagct gaaagagatt tcttacatcc aggcagaagg ttttgccggc 201361 ggtgagctaa agcacggaac gattgccttg atcgaacaag gaacaccagt attcgcactg 201421 gcaactcaag agcatgtaaa cctaagcatc cgcggaaacg tcaaagaagt tgctgctcgc 201481 ggagcaaaca catgcatcat ctcactgaaa ggcctagacg atgcggatga cagattcgta 201541 ttgccggaag taaacccagc gcttgctccg ttggtatctg ttgttccatt gcagctgatc 201601 gcttactatg ctgcactgca tcgcggctgt gatgtggata aacctcgtaa ccttgcgaag 201661 agtgttactg tggagtaata attaattaac ccctttggat aagaaggtct tcacatgtgc 201721 tgctaggctc caaatgtaca cctttccgta agggcaaagt caaatgtgaa aaaaaactgt 201781 tccaaagtta atcagaaatt tattttcata ttgtatcctt cggtatcaag tgaaaggagc 201841 atcatatgaa aacattatgg aaagtcctca aaattgtttt tgtcagcttg gctgctttgg 201901 ttttgcttgt atccgtctcg gtatttattt atcaccattt ccagctaaat aaggaggcgg 201961 cactgctgaa aggtaaaggc acagtagtcg atgttgacgg taaaaagatg aatgtgtatc 202021 aagagggaag cgggaaggat acgtttgtgt ttatgtccgg ttcgggtatt gctgcgcctg 202081 cttatgaaat gaaggggctg tacagcaagt tttcaaaaga aaataagatt gctgttgtag 202141 atcgggcagg ttatggatac agtgaagtgt ctcacgatga cagagatatt gatacggtat 202201 tggaacagac gaggaaagcg cttatgaaaa gcggaaataa gcctccttat attttaatgc 202261 ctcattcgat atccgggatt gaagcgatgt attgggcaca gaaatatcct aaggaaatca 202321 aggccattat tgcgatggat attggattgc cccagcagta cgtcacgtat aaattgagcg 202381 gagttgaccg attgaaagtg agagggttcc acctgttaac ctcgattggt tttcatcggt 202441 ttataccttc cgctgtatat aatcctgagg tgattcgaca gtcgttttta actgatgaag 202501 aaaaagaaat ctataaagcc attaacttta agcaattttt taatgcagat atggagcatg 202561 agcttttaca gtcttaccaa aacggcagca aatctgtgaa tctgcctgcg ccaaaggaaa 202621 ctcccgtctt gattttagat gcagtctctg accaaaatag acattcaaag tatgctatac 202681 aaaaccgaaa agactatgaa gcgtttgcgg ctcaattcaa tactgccgat ataaaggaac 202741 tgaggggaac acacagtatt tatttatatc agcctgatca aatatataaa ctgtccatgg 202801 agtttatgag aaaggttcgc taggatgaag ggttatcgta ttttaatcgt tgaggacgat 202861 gtgatgattg gtgatttgct gcaaaagatt ttgcagcgcg agggatatcg tgtgatatgg 202921 aaaacagatg gagcggatgt gctttcggtg attcagaagg tggatttggt cattatggat 202981 gtgatgctgc cgggtgaaga cgggtatcaa atgtctgcaa aaatcaaaaa gctggggctg 203041 ggcattccgg ttatttttct ctcagcccgc aatgacatgg acagcaagct tcaaggtttg 203101 cagatcggcg aggattatat ggtaaagccc tttgatccga gagagctgct attaagaatg 203161 cggaatatgc ttgagcatca ttatgggacc tttacgcaaa tcaaacattt gtatattgat 203221 gcggtaacga aaaaagtgtt caatgaaagc ctgcatgatg aggtattatt tactgcgatt 203281 gagcggaaaa ttttctttta tttatatgaa aatagagaca gtatcctgac aaaggaacat 203341 ttctttgaat atctatggca gctcgaagat agaaacccga atattgtcaa tgtgcatatt 203401 aaaaaaatta gagctaaaat caatgatcaa gcgggtgaga tgattgaaaa tatatatgga 203461 gaagggtatc ggctgaatac cgttgtgaag aaatgaagct caagacaaaa tatcagttgt 203521 tattgtttac ggccgtcatt agtgttccga tgctattgct ggcggtcagt gttttgatgt 203581 cggtgattta tgacagcatg tttaaaccga tgaatcatgg tatgcccttt cacaggtcgt 203641 ttgcataccc ggcaatgatc gttgtatttt tgatatcact cttattgtta gcttttttat 203701 tttcaaagtc gattcattct ctgttgcata aaatcaatct attaaatcaa accattcggc 203761 atttggcgag tgatcaaagg gtgcccgata aaattgaagt gaagcgtgct gatgaaatcg 203821 gggaactgat caagtcggtc aatttgttaa ttgaacggac gacatatcgt gaactggagc 203881 tgagacagca ggaggaaatc aaaaaggagc ttttgcaaaa actgcggcat gacattaata 203941 cacctttaac ggctctcagg ctgcagttat tttatttgga agaccaatgt catggtcagg 204001 ctgtattcga atcattgtat cagcaaatcg aatatatctc ggaattaact aatgaattca 204061 atctatattc cgctgagacg ctggaaagct cttatattgt aaatgaagaa gtgcgtctaa 204121 acgagctatt agaaacagcg gtgaaaaagt gggattattt atacagtatg agtgggattg 204181 agctgcacta taagccggca gatcaagatg tgatatggat gagcaacacg ttatggatgg 204241 aaaggctgtt tgataatatt tttcaaaata cgttaaggca ttcaaaagct aaaaagatgg 204301 aagtcacgat tgaacatggc gatgttttta ttcgtgatga cggtattgga tttgatcgga 204361 atgagagcag tgagggactt gggttaaaga ttattgagga tacatgcagg ctgcttgcga 204421 ttacttatga gctgcataca aatgataacg gaacggggtt cttgttttca aaagagtgac 204481 cccgctgatg tttttctttc tcctataaaa tttatataat agggagaaag aaatggggtg 204541 aacatcatat gtttaaaaaa atcatcaaaa cgattaagta cctctcaagc agttctagtg 204601 accgatatcg cagacaccgg cattacagca gcagccggcg cagacattat cgcagctaca 204661 gcagcagttc gggcaaaaga agacactacg accgttatgg cggcagtcat cgttacaaac 204721 gccggagcta cagcagcagt taatccaaaa aaagttcttg ttccgctttt gggacaaggg 204781 tttttttatg tgaccgattg aatggcccgg tttagatcct cgcgaatgga agcggtgtgc 204841 tgatactctt cctcaatgcc caataatctt ttcagcagca aggttacttc ctttgtcagt 204901 gttaattcct ccagccaagt gccgtttttc ttcttttttc ctttatattg agagtacagc 204961 aagaataaca gcgtttctcc gagatcgaag aagtcatcct gttttcgtac ctttatttcc 205021 tccatttctt caggagtcaa ttgtttggca aggccgaaat cgatgaggca gagcctgcca 205081 tcattgatga tgatattagg cgttctgatg tcgctgtgga agataaggcg atcatgcagg 205141 tattctataa tctcaagcag ctgcgaaatc agttgtaacg ccataagctc tgtgaacggc 205201 tgttttcgaa aaaataataa ttcttctata ttctctccct caatgaactg catgacataa 205261 taagcctgtc cgtctatgat gaattcatct atgaagcccg gaatttgcgg gtggtgaatg 205321 tttttgagca gttttatttc ctgctggaat cggactttct ctttttcctt tttggctttt 205381 gtcggccgaa gctgttttaa gacataaggt gtttgagcta ggatatcggt gcacaaataa 205441 accaaaccgt agcctcccat accgaggcac tcttcgattt tgtattgatg atttaagata 205501 acgccgttct ttagagggcg gtcaaatagc agttttttta gaagttttaa tgccatgtct 205561 gcacttccct tggttgtact gactatagtt taccttctag acggagaata aaaaagagcc 205621 ggataaccgg ctcggtataa gttaaaactg ctttgtcacg tcgtattcat aatctatttt 205681 tgcttttacg ttgctcatcg tcgatctggc tgtcgctaat gtattatatt taaaactcca 205741 tacctttgcc acactgagtt gatccgacaa agagatatca taagaccctg aagtcgagct 205801 gtttacaagg gcacggctcc attcgttatt ttcgcttgtc atgatcagat ggcgtgtatt 205861 tccctggctt ggtgtttgag tggcggttgt ttgaactctg gttacaatgg catcacgcgg 205921 tatcccagat tggtttgtta aatcaacctt gatcacgctg gagtcagaac ctgaggggct 205981 aaggcttgta tttcctttat tttcagcaac gccgctgaat tggaacgttc cgctgcctga 206041 tttgattcgg tcttcaattg aaagcgtaaa gtacatgttt ccagtatagg tgcctcgtga 206101 cactttcaca tagaaggtat ccgtcgtgtt ttgggcgtct gcatttgcat aaataaaaga 206161 agaaaacgta ttagggttaa taacttctgt cccttgagaa acaggtattc tgttcttgtc 206221 ataaatttca attttcatcc ctgtatacgc gctctggtat gtactcctca tgtatacttt 206281 ttctccctta ttagccgtaa aagtgaaata ggcttcatct tgaccagctt ccagtattgt 206341 tgtatcgata tttttatatt tccaataacc gatcggcatt gcggtatcaa atgaattgtt 206401 tcctgtgata gcagtgactc cgacagctga tgccgaatac gtaaaggtag ataagacaga 206461 aagcataaca gcgaattgaa taagccattt tttcaccatg caaacaacct ccttttattt 206521 ccatcataca taataacgat ttaggtgtaa ataaatgttt tttgaggtta atatatacat 206581 tatattcgcc gataaaaaag aataagagag aatactcggg agggaattca atgcgtctga 206641 atcggcaatt tatccgcact cagctgattg cacagaacat attgagcaag aatgcgcctg 206701 ccaaacggga gaatgcgact gaaaatccag cggcagttct ggaaaaggca tatagcaggc 206761 ttaagtcaca atcttcaact gggggaatca atcagttcaa ttattctaaa accagcgtgt 206821 cgggaaacag cgggacgttc agcaaagtgt atcaatcagc gaatgatcga acagtgacag 206881 acacagggga agaaacagtg attcaatccc aaaaccccta tgaatctgag agtgatatca 206941 gaatcaaaat actagatgaa aaatacagca ggatgaatgc gattaataaa acaaagtctg 207001 atccattagg ctatattaag gataagtacc aaaattcaaa gtctccttat ttcagaagtg 207061 atctgtcagc tgcagaaaga caggccgctt acgataatga aacagaatgg ttattcaaag 207121 ggaaggcgca aaactataac cttcaggatg ctgtgtttcg gaatgtcaca tttcatgggg 207181 aagtggaagc tgagaatgaa aaggtgtatc agcggggaca ggttaaccag cagctgcaag 207241 tactgttgaa tcgaaaccat attcatattc cagaggggac agagctgacg tttacaatca 207301 caccgattga ctatcaggtg cgggtaagcg ggacagacga tcaggatctg atcaagcaaa 207361 ttgagcaagt gctgcaatct ggagacaaca gcaaagaact atttttacac atcatgaaaa 207421 gtcaaagcag tgattcagca caattttccg aagaggccta taaaaagtat caggcagctc 207481 gtgagatgta tgaagttaca ggctaccatt tgaaggattt agaagtgatt gatgggcggt 207541 acgtcacgcc tgagggacgt gacttaatgg atgtatataa ggaagagctt gaaaaagatc 207601 cagtgcagaa acaaacggct tcttatgcta tatcttacta tcgttcagag ctcagtaaaa 207661 tcgcggaagc cgggtataat gccattccgg atttcatcct atcaattgat tacagcaatg 207721 gatctctgag agatgtggga caaagcaaga gctatgggac cggagatacc gggtggcttg 207781 aagcattaaa gcgtcaaacg ggtgtgaatt attaggtaag ctgttcatgt aggacagctt 207841 attttttatg agaatctaag gggtgaatta atcccaatat tcaaataatt ttattatttt 207901 tatataaaag attttaaaag aagtgaacga ttcaaaactc tgaacaaagg tgtttacctg 207961 aaaaaaacaa ttgtattttc cagagaaatt tattatgatg aaataagtaa tttaggagat 208021 tatataacaa ttttaagttt gaattttctg attgttatca ctgattcatg tgaaggcaag 208081 caggtctgct gttttctcat ttatgagtat tttgttagga ggaggaagag gagtggcaaa 208141 taaagaatta aagaggggcc tgggcgcgcg ccatattcag atgatcgcct tgggcggtac 208201 aatcggtgtt ggcttgttta tgggttctgc cagcacgatt tcatggactg gcccatctgt 208261 ccttctggct tatgcaatat gcggaatttt tatctttttt attatgcgtg cgatgggtga 208321 aatgctgtat gtcgagccga gcacaggttc ttttgcgacg ttcggccatc aatatattca 208381 tccgatggca ggttatataa cagcatggag caactggttc cagtggatta tcgtcggcat 208441 gtcagaaatt atcgctgtcg gttcttatac gaagtattgg ttcccggatt tgcctgcttg 208501 gatacctggt atcgtggcaa tggtgattct tggtgcggcg aatttaattt ctgttaagtc 208561 gtttggggaa tttgagtttt ggtttgcgat gattaaaatc gtgacgatta tcttgatgat 208621 tattgcggga atcggaatta ttttcttcgg ttttggcaat ggcggagatg cgatcggttt 208681 gtcgaacctg tggtctcacg ggggcttctt tgcaggaggt ttctcaggtt tcttctttgc 208741 actgtctctt gtcattgcag cctatcaagg agttgagctg atcgggatta cagcgggtga 208801 agcgaaggac ccgcaaaaca cgctaagaaa tgcgattcaa agtattatct ggcgtatttt 208861 gattttctac attggcgcta tttttgtgat cgtgacggtg tatccttggg atgagctcaa 208921 ctcactcgga agtccgtttg tgtctacgtt ctcgaaaatt ggaattacgg cagcggccgg 208981 cattattaac tttgtcgtga ttactgcggc aatgtccggc tgtaacagcg gtattttcag 209041 cgcgggccgc atgctgtata cactgggtgt caatggacaa gcaccgaaat tctttaagaa 209101 gatttcacgc aatggtgtgc cgctgtatgg cacaattgcg gtgctgatcg gtttggctgt 209161 cggcgttgta ctgaactata tcgcgccgcc gaagatcttt gtctatgtat acagcgcaag 209221 cgtgctccca gggatgattc cttggtttat cattttgatc agccatatcg gattcagaaa 209281 agcgaagggt gctgcattag ataaacatcc attcaaaatg ccgtttgctc cttttacaaa 209341 ctatttgacg attgctttct tgctgatggt tctggttggc atgtggttta acgatgatac 209401 tcgtatctcc ctgattgtag gcgtgatttt cttagcgctt gtggtcatta gttattatgt 209461 gtttgggatt ggcaaacgca cgcaggccaa tttgacaaaa agcgaacaag cagctgaata 209521 acgataaaaa agagacattc acggatgtct ctttttttat ttttcgcgta tggattttcc 209581 ctattttagc aagctatagg gtaaagatag cagaaggaaa ggtgttcata aaatggatgt 209641 tacactcggt tatttgcgcg aatcactttc gaatcatcta gaaaatgaag tctgccagcg 209701 tatttgcaag aagatgctgg cgaagcgtta tgcaaatgaa gaggaatttg taaaagactt 209761 agatgataat gaaatgtctt ttttgaacca tgtattagaa aaagaaatta agtatgccca 209821 gaatgaacag gatcaaaaac gggccaagga attaaacgag gtgtatgaat tactgctttg 209881 agaaaggcgg gtaagaaatg ggagcaattg aacgaagcgg atatacattt cagccggagt 209941 ttagcgttgt ccgtcaaaac ggagccatcc atgtgtacca tcaaggagaa tttgtggaag 210001 aaatcgaatt tgaatttaac ggggaatatc ccgatcatga tttgattgaa gagcttgtga 210061 atcattattg ttttgagcat gagatttaga gccctgccgt gcagggctct tttatttagg 210121 atgtaatcag gccatacttt ttcaggatat ccacggtgat gtttttggct tttgtgccgg 210181 aatcatcgac attggtgaca aagacataag agccatgctc tgttttgatg aatccgacaa 210241 accatcctaa tcccatatca gtcaggcggg ttccggtttt cccgtagagc gtgtaatgat 210301 cgccttcctc ttgaatcatc atgcgcttga cgattttcat caccggcttg tcaaatggaa 210361 gctcctcttt agccagtttc tccaaaaaag tttcttgttc cagcggagat attgtgagcg 210421 agctttgcag ccaaaactgg tcgattcccc cgctgatatc ctcgttgccg taagatagag 210481 tatgaagcca tgttttcatt ctttcctcgc cgatatctct cgctaatgcc tgataatacc 210541 agattgcgga ttcgcgcatg gccgagccaa gcgtatggtc gcggttccat gattcgaatt 210601 cacgcttgac cccgtcccat cgtttaacat cgtattcatc tcttacagct ttgacctgca 210661 aaccgattaa agcgttcacg actttaaagg tggattgcgg agtttgtctt tgatttgccc 210721 gttttctgtt atagacaaat gtctgatcct tttgtaaatc gtgaagaatg aaggttccat 210781 ccgtatcctt gaattcatca tcgacattca ttttgctgac attcaagtgt ttttcatgag 210841 cagatgatgc tgcgtggacg gagaagccgc cgatccctgc aatactcagc acaagcacaa 210901 catatatcca ttttttcatt ttgttctccc cttcgttttg attaactacc ttttctctct 210961 ttcgtttgtt cttcctttaa aaaataatca aaaagcgctt aaatttggtt ttgcaaacaa 211021 atactgttac tgggtttata gtcggaagat aacgtgaaaa tagagggtaa aaaggaaggc 211081 agggtaagcg gatgaatgag cagattccac atgacaaaag tctcgataac agtctgacac 211141 tgctgaagga agggtattta tttattaaaa acagaacaga gcgctacaat tcagatctgt 211201 ttcaggcccg tttgttggga aaaaacttta tttgcatgac tggcgctgag gcggcgaagg 211261 tgttttatga tacggatcga ttccagcggc agaacgcttt gcctaagcgg gtgcagaaat 211321 cgctgtttgg tgttaatgcg attcagggaa tggatggcag cgcgcatatc catcggaaga 211381 tgctttttct gtcattgatg acaccgccgc atcaaaaacg tttggctgag ttgatgacag 211441 aggagtggaa agcagcagtc acaagatggg agaaggcaga tgaggttgtg ttatttgaag 211501 aagcaaaaga aatcctgtgc cgggtagcgt gctattgggc aggtgttccg ttgaaggaaa 211561 cggaagtcaa agagagagcg gatgacttca ttgacatggt cgacgcgttc ggtgctgtgg 211621 gaccgcggca ttggaaagga agaagagcaa ggccgcgtgc ggaagagtgg attgaagtca 211681 tgattgaaga tgctcgtgcc ggcttgctga aaacgacttc cggaacagcg ctgcatgaaa 211741 tggcttttca cacacaagaa gatggaagcc agctggattc ccgcatggca gccattgagc 211801 tgattaatgt actgcggcct attgtcgcca tttcttactt tctggtgttt tcagctttgg 211861 cgcttcatga gcatccgaag tataaggaat ggctgcggtc tggaaacagc cgggaaagag 211921 aaatgtttgt gcaggaggtc cgcagatatt atccgttcgg cccgttttta ggggcgcttg 211981 tcaaaaaaga ttttgtatgg aataactgtg agtttaagaa gggcacatcg gtgctgcttg 212041 atttatatgg aacgaaccac gaccctcgtc tatgggatca tcccgatgaa ttccggccgg 212101 aacgatttgc ggagcgggaa gaaaatctgt ttgatatgat tcctcaaggc ggggggcacg 212161 ccgagaaagg ccaccgctgt ccaggggaag gcattacaat tgaagtcatg aaagcgagcc 212221 tggatttcct cgtccatcag attgaatacg atgttccgga acaatcactg cattacagtc 212281 tcgccagaat gccatcattg cctgaaagcg gcttcgtaat gagcggaatc agacgaaaaa 212341 gttaaattaa aaagctctct tcctttatcg aagagagctt tttgattact tctttttttc 212401 atcgtagtat tggacgggat acatggagcc ttctgatacc attttgttgt cctcgatatc 212461 ttgcgggtcc gggtggccgg ctttatcaac tgggaacgtt tccatgtctg gctgttttgt 212521 tattttcatc ttcatgctgt gaatgaattc tcttgccttt tggcgatttg acgggtcttt 212581 taatagataa gaagtgatgc cgacagttga aacagcgaga cctgaaagta acagcttttg 212641 tttcatggtg atactccttt ctattttaag aatagtgttt cctgtatcat tcccgttttg 212701 gaaattgcta aacctgttgt gtttttatca ttggaattaa cagtaaattc catttaagaa 212761 gaaactagtg acttcattcc tgtattggaa ggtaatatac attgacttat tatagatttc 212821 agtcaaaatt cgataaatat tgacaaagta aagtaatcag aataataata taattagcaa 212881 gagaatgtca tcatacatga aaggtgttta cgatatgaat caattgcatc gaagaatggg 212941 aacgttttcc ctcatgatgg tcgggctcgg gtcgatgatc ggttcaggct ggctgttcgg 213001 ggcttggcgt gcggctcaaa tagcaggacc agctgctatt atttcatggg ttattggaat 213061 ggtcgtcatt ttatttattg ctctttctta tagtgaacta ggttctatgt tccctgaagc 213121 ggggggaatg gtcaaataca cgcaatattc acacggttcg tttatcggtt ttattgcggg 213181 ctgggccaac tggattgcga ttgtgtccgt cattccggtt gaagcggtgg cctccgttca 213241 atatatgagt tcttggcctt gggaatgggc gaaatggaca agcggtttgg tgaagaatgg 213301 aacgctgact ggggaaggac tagcgtttgc ctctgtattg cttctcattt attttctgct 213361 gaactactgg acagtcaatc tattttcgaa agcgaattca ttaattacga tttttaaaat 213421 tattattccg ggtcttacga ttggagcttt gctgtttgtc ggattccacg gagaaaactt 213481 tactggcggt caaagcattg cgccgaatgg ctgggcaagt gtgctgacgg cggttgccac 213541 ttccggtatc gtttttgcgt ttaatggttt ccaaagcccg attaatatgg cgggtgaagc 213601 aaaaaatccg gggaaatcaa tcccgattgc ggttgttggc tctctttttg ttgcgacagt 213661 gatttatgtc ctgctgcaga tcgccttcat tggagctgtg aatccttctg atattgctca 213721 cggctggagc catctgaatt ttaattctcc ttttgctgat ctggcgattg cgctgaatat 213781 taactggctt gttattgtgt tatatgcaga tgcatttgta tcaccgtctg gaacggggat 213841 tacgtatacg gcgacaacgt cccgaatgat ttacggaatg gaaaaaaaca aatacatgcc 213901 gagtatattc gggaagcttc atccgattta cggcgttccg cgacaagcaa tgttctttaa 213961 cttgattgtt tcgttcatct ttttgttcct gttcagagga tggggcgtat tagcggaaat 214021 tatttctgtt gctacgttaa tttcttatat caccggcccg atcacagtga tgacattgag 214081 acggacgggg aaagacctgt acaggcctct tcgtttaaaa ggcttaaatg tgattgctcc 214141 gcttggattt atctttgcgt cactggtgct gtattgggcg cgctggccgt taacaggaca 214201 ggttctgttt attatcctga tcggtcttcc gatttatttc tattatcagg cgaaggcgaa 214261 atggaaaggg tttggccgga actttaaagc cggcgtctgg atggtgtttt atctgctggc 214321 catgatggtt atttcttatt tgggcagtga taaattcggc ggcctgaatg tcattcatta 214381 tggctgggat atggttctga ttgcgatggt atcccttgta ttctatgtgt gggcgctgaa 214441 gagcggctac cagacagaat acttaaagga tgcgaaagag ataaattctc agctgcttaa 214501 tggacagtca gaagctgctg ccggaaaaga ataaaatata gaagaaaacc ttgcgatagt 214561 tgtcgcaagg ttttttgctt ttaataaccc ttttttactt tgtggaaaag atcaggatag 214621 ttggtgaaca ctcctgttac gccccaatca agcaggcgat gcatatcagc ttcattattg 214681 actgtgtaag gatgaagcag gaggccgtgg ctgcggatca tacggacgtt ttcttgattt 214741 aaagctttat aatccgggcc cgcaccgaca gcgtatgttt tgatttcttc cagggcagca 214801 tctgtcattg acgccatttg tttggcttcc agcaattgaa cggtcggcag gtttggctgt 214861 aattgatgga cttttaccag gctttctttg ctgaacgatt gaatgatcac ctggcctggc 214921 ttagaatgct ttcccagtaa tttatgtttc tgcaaagaag cgatcagttt ttcttccata 214981 cctgggtagg tgtcaggcga ttttgtttca atgtagtagt tcgcgtgctt tccgaaacgg 215041 tctaatacct cttctaatgt aggaacttta aggccgacgt actgcggctt tgctttttcc 215101 ggataggctt cattaaacca agaaccggcg tcaagcttct taatgtctgc gagcgtatgg 215161 tctttcaccc aacccattcc gtttgtggtg cggtccagtt tttcgtcatg catgacaatc 215221 aattttccgt cttttgtcat ttgcagatcc aattcaataa aatcagcttt cattttctga 215281 gcggtttcgt aagacagaat cgtgtgctca ggcacatatc cagaagcccc tctgtgcgcg 215341 acggtcagga tacggtcagg tgacagcagg tttccttttg acgctgccga cactggcgtt 215401 accataaatg agagtaagcc cagcgacaga acaaacaagg ccagtattct attttttctc 215461 atgatttctc ctccttatag ataagcacta cctgtctttc ataataaaaa acggatgtaa 215521 acggcgtgtt ggaaaactat taatctttta tgtgtctttc ttaaacatgc tctgcccgtt 215581 ttcctgtatt ccacgtcaaa gccaagaaga cgatggcaag aatgcaggat gagatcagca 215641 tgataaagcc gccgttccag ttaaaacggt ccacgacaaa gcccataatg gcgtttgcga 215701 aggcggatcc gccgatgtat ccgaaaaatc cggtcaaacc ggctgcagtt ccggctgctt 215761 ttttcggtgc taggtcaatt gcttgaaggc cgatcagcat aacaggtccg tagattaaga 215821 agccaatgct gatcagggcg atattgtcca cgagcggatt gccggccgga ttcagccagt 215881 acaccaatac ggcaatgaaa acacccgcca taaacaaaac gcctgccggt gcccggcggc 215941 ttttgaagaa tcggtcactg atccagccgc acaagatcgt tcccggtatg cctgcgtatt 216001 cgtaaagaaa atacgaccag cgtgagtctt caggagaaaa gcctttggct tctgttaagt 216061 aagtaggcgc ccagtcaacc acgccgtatc gcacgaaata aacaaataca ttggcaaaag 216121 cgatgtacca aagaaatttg ttgttcagca catattgaaa aagaatttct tttgttgtta 216181 attctttttc ctgattttta aaagcgtgtt ttggatagtc attccgatac tcttcaattg 216241 gcgggagtcc gcaggattga ggcgtatcac gaaccaataa aacaattaaa aatgaaatga 216301 taatggcgat gatggcaggg aagaaaaaca cgcttttcca agtgacgaac atcgcgatcc 216361 caagagtgac aagcggagca agaataccgc cgcctatgtt atgggcgaca ttccagatcg 216421 acatttttgt gccgcgttca cttatggaga accaatgggc catcgtcctg ccgcatggcg 216481 gccagcccat tccttgaaac catccgttga taaacataaa aataaacatg atggtgacgc 216541 tcgaagtcac ccaaggcatt gaaacgaata gaatattaac gattgctgat aaaaataggc 216601 ctgtcgccag aaaatatctc ggattacagc ggtcagacac cattcccatg atgaatttgc 216661 tgaagccgta cgcaatggac acagcggcca gcaccaaacc cagttctgtt ttcgaaaatc 216721 cctgttcctg cagataagga atggcaaagg caaagttttt ccgcagcagg tagtagcctg 216781 cgtagccaat gaaaatacca atgaatactt gcagtctgag ccgtttgtat gccgcatcca 216841 tctttgaatc atccagtctc tcaatatgag gagccggttt aaatatatta agcattaata 216901 attatccccc tttgctgttt gtgctggatg tgtggcgtgc ctcctttccc gaaaaacaaa 216961 aagagccaga aaacacccct tgtcaaaagg ggttggattc ctggctctcc tcatctccat 217021 ccaagctatt aacttatcat gatagcgctt tcttaaatta tcatagtccg gagcgaatgt 217081 aaacgggtaa ttttcaaatt gggccttagg gaagtgaata ttatcctttt actaaatgca 217141 attatatttt tttactagta acataaaaat ctggagggag gctgtttaaa gatggatgaa 217201 ttagatatcg cattctttat tttaccgtta ggaattatgc tgctatcgat tgtcgggacc 217261 tgtatttgta aaaacccgta tctgatgcca atgcttagtt tggtgatttc tcttgtgctc 217321 acctttacca tttttaatca atcatttttg ggatgggctg ttgtctatag cttggtttct 217381 ctggctttat cctatatcac attgattgtg gtaaggaaaa ggaaggaatc aggaaattaa 217441 aaagacctca ctttctaaca tatcgttgac taaagcaact atatgtgatt ataattgctt 217501 tagtcaacga tattagaaag tgggaattga tttgaaaaca agagaatcat ctgtcgggtt 217561 aaaattcaga aagttcaatc gattttatac aaacgtcctt ggtttcctta atgagcacat 217621 ttacgacagc ccgttttcct taacagaaac acggatttta tttgagattt ataatacgcc 217681 taattgtacg gcaaaagctc ttcaggataa gctggggctt gaccggggat atgtcagcag 217741 gattgtgaag cagtttgaaa aagaagattt gatttataaa cagaggagca aagatgacgc 217801 ccgccaccat tacatttttg tcacagaaac aggaaaaacg atttataaaa agctggagga 217861 gaaagccaac gaacaagtag aactgatgct gaaggtaatc aaccaaaagg agcagcacaa 217921 gcttgccgag gcgatggcag agattgaagc gatcctttca cagtcgcttt ctgccagagc 217981 atcagagata tcgattagag attattttct ttcggaggat cttcaactcc ttattgagaa 218041 acaaagacaa ttttacgcgg aggctcacgg ttgggatgac acgtttttag cttatcttca 218101 ggagacattt gacgctgaca tcgaaaaaat atggattgcg gaaagcggcg ggaaatttgc 218161 cggctctgtc gggttggtca agcacgatga aaagacagtc cagctcagat ggtttctggt 218221 tgatgcggat tttcggggca gggggcttgg cacgcaattg ctggagcatc tggttgcata 218281 ctgccaagac atgaagtttg accgcatttt cctttggacg gtgagcacga tggctgaggc 218341 tcgtccgctc tataaaaaat ttggattcag gataagtgaa gtaaaacaag aagcgccatt 218401 atggggacag cagctgacag aagaacggtg ggatttggag ctgtcatgaa aagactgcat 218461 tatgcgtgga tcatcgtctc cgtcaccttt ttgatcttat tggcggttca gggggtgcgg 218521 ctgtcgtttg gtgcgtttgt ggagccgtgg gaacggcagt tttcaatcga tagaagcacc 218581 atctcgctga tttcgacggt gagttttatt gtttatggca tatcacagcc tgtgatcggt 218641 cggcttgtgg acaaatgggg tgcccgggct gttttggcat ggagtgcgtt actgacagga 218701 gtcagcattt tcttaacata ccttgtgact tcgccttggc agctgttttt gctttacggg 218761 ctgggtgtct cgcttggagt gggcggagca tcgaatgtgg cggcaagtgt attggtcgtc 218821 aattggttca gcaaaaagcg gggactagcc tttgggatca tggaagcagg ctttggcgcg 218881 gggcaaatgc ttctcgttcc cggctcactc atgttgatcc attggtttag ctggaagctg 218941 acggttgtgg tgttgggact gctgttaatc gtgattgtct ttccggctgc gctgctgatg 219001 ctgcggaaca atccttcaga aaagaataca gagccgatag gcggactggc tgcatcagaa 219061 aaagaaacag cacccaaaac aacagctctt tcagtggccg ggatgtttcg tatgaggcaa 219121 ttctggttct tgatttttcc gtttttgatc tgtggattta cgaccgtggg gctgatggat 219181 acccatttga ttccgttttc tcatgatcat ggcttttcaa cgacagtcac gagtgctgct 219241 gtcagtctgc tagcaggctt taatattgct gggatcttgc tgtccggaat tgtagcggac 219301 cggtggagca gccggaaaat cctgtgcatt ttatatgcgg tgcgggcgct gtcgatcgtg 219361 attcttattt acagccacga gccctacttg cttttagcct ttgcgattct gtttggatta 219421 gtggactttg caacggtagc accgactcaa atgctcgcca cccagtactt tcaaaactac 219481 tcgatcggcc tcatgattgg ctggctgtca ctcgcccatc agatcggatc ggcactaggt 219541 gcgtatgtgc ccggcgtcat ctacacggta acgggtgagt atacactggc tttttatttg 219601 tcgattggaa tgctcgtgct tgcgagcgta atgaatgtga tgctgaggga gccagctgcg 219661 gttacgcgtg acagtgcggc tgtggtagac aagtgatgag gacaaaggga aagcatctct 219721 gatttcgaga ttattcagag atgctttttt tgtatttttg ttctaatacg aagtcgatca 219781 taccgactat gcgggcgttt tcggattttt gtttgaagcg ttcagaaatt tgaacttttc 219841 ttgaaaatgg ggaaacaata aaaacccaaa aaaggccgat caaggcaaaa aacatttgta 219901 cagctaattc tattaattca ttaaaacgag tgctgaaaaa atagaagtat aacgttatta 219961 atgtcacagt acatacgatt ttggcaagtg tgtttgaatg taagcaatgg ttcactaaag 220021 aataccttta attgattcag catgattgaa tcatatttgt ttaggaaaat aagaagttct 220081 ttatcatctt ttttatgttc taaaataaag ttgctgtttc tgtttcttta tatgtatggt 220141 ggtctacatt caatatatac atctcttaaa gtataaaaat tgagtatttc ttagtaagga 220201 tgaaacaaaa ttacatgatt tttttgttat atctttcagt tagaataaaa tctataactc 220261 ctctcattcg caaatattcg gctctctgtg caaagtgcag aacagtatgt aattgtcctt 220321 ttctagatat atttaaaagc tttatcaaat caataaggat tttcaagaaa ataattaata 220381 atagaaagat aaaaatgtgt ggtatgtcaa tgtaattgat ttgtcctgaa aataaagaag 220441 ttgcatagac aacaataata cttccgcaaa acatcaaact catataatgt ggaagggaaa 220501 atggacgagt tgaaaaatat gcttttaatt ggcttagcat agcattatct cttgtatcta 220561 agtagcccaa aagctcttta tcatttttac taattgtaag aacatgattc aatacagcac 220621 taaaattcat tgaatcttca ttatcagagg cagtatgttt attagcctgt atgttttgtt 220681 gatccatttt atatttttta taaagtattg tattaattaa cttgtttttc tcatagaatt 220741 cagatcgttg attaagggat gcttttcctt tgtttttatt tccttttttt atgattttag 220801 tataagtcat aaaaatacaa atgactgtaa aaatagaaaa cactgcaggt gaaatatctg 220861 aaagaatagt attggtgaag acttcttttg cttggatgaa aaggaaagaa gctaaagtca 220921 tagatataaa catgcataaa actgctactt tcacaagaaa ctgaagcgga agagaaggtt 220981 ccgaataata gtgcttcaac tggttgagtg tcagagaatc ttggcgaaaa agataatcta 221041 ttatctcctg ctgattttgc atctgattga tatcatgagc gatgtttttt gttttttcaa 221101 aaactatttg atcatttttc atttttgata aacctccaaa agacgataga taaactaaaa 221161 aaactgcatg agcatatttt aacttatgtt catgcagttt tgtattaaag ttagctagta 221221 taataagcaa aaatggccag taacatagca gataatgcgg tagcgacttt gactccttta 221281 ttgttcgtta aatcactgcc catattccca attagtaaaa gtgcagcaac acctacaaca 221341 gggaataaat attgatcata agacggccaa tctaacgcta attcactctc gggagacgta 221401 actggtactc ccttgtacgt ctttatttta aacgtaatcg tagtcgttag tccagttgtg 221461 acattgtcac cgactggaat atcaggtgta tagattttaa tttgaatgtt taaagattca 221521 gctgttggat ttacataaac ctccaaataa ccgttgcgta ctgataagct cagactattt 221581 aaaaggtttt gataagagtc gatttgtgac gcagtgagag acgtttgagt gtcgcccaat 221641 aaacccgtga tataggcacc tggtttacca tttgtaatgg taattgtgtt tggtgaacct 221701 tcacttggta tggttgccag aagtgaagtt gatagaataa tatccaactc aggtgatgtg 221761 aaaatggttt ctgtcgtatc aaattcaaac atcgcgtttg ccagacttgt tagattttct 221821 aaagctggaa tggtagataa aatgtctgtc agtgtacgca gtcttgcatc atataccgga 221881 tcagacggcg gatttacatt gcttgcacct gagtctcttc ctgaataccc gtctttatca 221941 atcccgatgc ttccagagcc gcttccgatg gttccttcat aaaattgatc aaaggcccag 222001 ttgtttggca tcggatagcc gagattgccg ctaaatcctg ttgacatatt tgccacaaaa 222061 ctatactttg tcagtcctgc ttcagatgta cggatacaaa tgtttcttgg tccgtaaacc 222121 cctatttcat acttaggtgc ggttgaaaat gtctgcattt ttgtaaatgc tgacttaatc 222181 tcttggaaat aaggaatgat tttatcggtc acttcataat cgtatgcatc aaaatcgaca 222241 gcgaaataaa tggtcgtgcc tgacggaaaa cctaatcttc tagcagcaga agcggcacta 222301 tatgcatctc ttgtgccttg gtctttgaca aaataagaag attcatagcc gccgtcttga 222361 taaattggga aaaccttcaa tccggcatca agaataactg caagctcttt agatgtcagg 222421 gctttagatg tgaggccgct gcttgtccgc acatttccgg tcaaatatct gccaaccgtt 222481 ttataaccgt tattccgcag tgtttgagct ttttctgcgg ttataattgt agcagtgtca 222541 caagcagaag cggtgcgagt tgtgtctcct gagcttgata ataaagcttt aatggttggc 222601 atatctgcat aacctgtttg cggcaggcac atgaactctt gaaatgcttt aacagctgaa 222661 acaacaccca caccatattt gccgtcaaac tcaccaggat cgaacgattt tccgttacaa 222721 tagagggcgt actgaacaat taagacaaat cctgttcttg aatcgccggg agttaaagta 222781 gggcacaaac ttgtggtgcc gtttccgaaa aatccattgg caacacttgt gctcatgcct 222841 tcttcttttt gcagggcata aataagagct ttatttgtat cgcggccata cagtccgtca 222901 caaggcatta acccgatata gtcattgtag tctcgattta agttttgttg aatctggcga 222961 attcttgaat cacccccaga caccagctta aaagcgctca tgtctaataa ggctttcata 223021 attaacgtgg tgacaatccc atcctgtgtt gtcagtccgg cagctttttg aaattctttt 223081 accgcatttt ctgttttttc gtaaaagacg cctgtaaaac cgccgggatt aaagccttta 223141 caccataaag ccccttgtaa aataaaattc atgttgcttg gttttgaatc tggagcttgg 223201 cgtttaagag gcttaaataa gcgctgtgtt gtcggcccga agttatcggc tggctctgag 223261 atacccaatt caatttgaag cgcccgagtc agaccgtaga tcgtatccca cccagttttc 223321 ccgctttctt caactgggtt atacccatgt ttgccgctgt acgtatcgtt cagccattgc 223381 tgtgtgatta agaccatttc atcaaccatt tcgattcctc ctttgttaga ttgcgttcat 223441 ttataggtgg caaacgtagg acaaaataaa aaaatggatg ccgttaagca tccattttac 223501 atccgttctc caacagcttc gctttcggtt tcagctctga aatgtagagg cctaaaagtg 223561 taagcgcgcc tcctagaaga gcgatccatg tcatgttttc gtgcagaatc aggacagaag 223621 cggcgatcgt gataaccggg accatgtaaa tatacgcact ggatttgacg gctccgagca 223681 ctccaactga ataattccaa gtggcgaagc acagggcaga agcgccaatc cctaagaaaa 223741 gcatgttgag tatatttgaa gcagatgaaa atcggcttag gtcaaaatgg aagtcgaaca 223801 aaaataaagc gggaaccata aacaataaac catacaaaaa tactctctgt gtcagctcga 223861 tgatgtggta ttcgtaggcg cttaattttt tcatgaatat cgagtatccg ccaaacacga 223921 gagcagcccc ggctgccatg atgtctccga gcggatttag acgcagtacc acattgccgt 223981 taaacgtaat caataaaagc ccgatcagtg ccgagataaa tccaatcaaa aaagtcagac 224041 gcaatttttc gccttcgagc agaaaatggg ccaaaaccgc agtgatcatc ggtataatgg 224101 acacgatcat gccgacattg gaggcgtatg tataggtgag agctatattt tctaatagaa 224161 agtataaggt tacgccaaat aaaccagctc cggcaaacaa cagctcctgc cgccaatttc 224221 tgaacggaat catgttggga cggacgagga taagagcgat aaagcccatc aaaaaccgat 224281 aaaataatat ttccattgga gagaagtcag ccagcagaac ttttgtcgaa ataaaggtcg 224341 tcccccaaat cagaatggtc acaatggctg cgatatgccc cgaagtttct ctttgtatgt 224401 tcatctgtga agctcctttt caaaaatctt catgtattgc ttcggcgtca gccccacctg 224461 ccgtttaaaa aacttcgtca tatgactctg atcgctgaat cctgtctgaa atgccgcatc 224521 aatcggcctt accccttgtt caaggagttt tttggcttga ttaatccgga ttgtttccat 224581 gtagctatta ggggtaatgc ctttttgttt tgtaaatgaa cgcaataaat gatacttgct 224641 ccagcctgtt aattcactca aatcattgag tgtaacattt tcggcataat gctcttctaa 224701 aaattcacaa accattttga cttcgtctga tggttctgga acgctgctaa ggaacgtgac 224761 atctgaataa tggcggatca gctcctctaa tagatgaaga aacagctcct ccttacgcaa 224821 agcttgtttt tcctcggata tcaaaatatg caattcctgc aggctggctg tcagctcatg 224881 gcggaataac acatgctggg agaaataagg gagatgcccg gagccagtaa tctctttcac 224941 cgccttctcc atgatatccg gcatgacatt gatacaccga taatcaagcg tccggccgtc 225001 aatctgttca cagctatgcg tgtcacgggg gttaaagagg agaagatcac ctggattgat 225061 gatatattct tgatcctgac aggccagata ccgttgccct ttttcaataa atccaatcac 225121 ataataatcg tgaaagtggt tcgggaactt ctgcataatt cccttgaagc ggtaggcttc 225181 tatatgaagg tgtgggtcaa gctgcagtgt gcgggtttcg ttttgcatgg gatgcctcct 225241 gtcggtgtgg tggtcttgga ttaagtgtag catgattttg ggggatttct tgtatgatgt 225301 tgctgtttag gaatagagaa agcagaccgt tatttgtctg ctttcgttta agaatttaaa 225361 agattttaac cctcaataat aattttatct tttttaataa aaatttattt ttcaaatatt 225421 tcagttataa tggtttggaa cagataggag gggcaaagat gtatcaatca aagaaggttt 225481 tattgttagg ttcaggtgaa ttaggtaaag aggtagtgat tgaagcccag cgtcttgggg 225541 tacagacggt ggcagttgac agttacgagc atgctccggc gatgcaggtc gcgcataaca 225601 gttatgtcgt tgatatgctg gacccagagc agatcagaac catcattgag aaagaaaatc 225661 cggatttgat tgtgcctgag gttgaggcga ttgcgacgga tgaattgctg aagcttgaag 225721 aggaaggatt tcacgttatc ccgaatgccc gtgcggccaa gctgacgatg gatcgggaag 225781 gcatcagacg acttgcggcg gaaacgcttg gacttgcgac agctggctat gaatttgcga 225841 atacatatga tgaatttata caagcggcag ctcagatcgg ttttccttgt gtcgttaaac 225901 cattgatgag ttcttctgga aaaggccaaa gtgtgtgccg ctctgaagcg gatttagaga 225961 gctgctggga gacggcgatg gaaggcggac gggtgaaaaa cggccgcgtg atcgttgagg 226021 agtttatccc tttcgaatca gaaatcacac tcttaaccgt acgtgcggtt aacggtacgg 226081 cattttgtga gccgatcggt catgtgcaaa aggacgggga ttatatcgaa tcgtggcagc 226141 cgcatgatat gacagagcag caaatagaag aagcgaagca tattgcgaaa acgatcacgg 226201 atgagcttgg cggatacggc ctgtttggtg ttgagctgtt ccttgcgaaa gatagggtat 226261 atttcagtga ggtatctcct cgtccgcatg atacgggtct tgtcacgctg gtgacgcaaa 226321 atttgtcaga atttgcgctg catgtccggg cgattctcgg ctttccgatt acagaaatca 226381 cacagctttc tcctggcgcc agcaggcccc tcaaagcgcc ggaagaatta gcggattaca 226441 ctgttgaagg attggaaaac gcactggcag tcccaaagac tcaagtgcgc gtctttggaa 226501 agccgataac aaaagccgga cgtcgtatgg cagttgcgct ttctgctgct gattcagttg 226561 aaacggcaag agagaatgca aagaaagcgt tggaccagct aattttaaaa tagagtttga 226621 acaggtcttg tcatgggaca aggcctgttt ttttctttct ccgtaaaagt tttatcataa 226681 gaatcagaaa cctgattata atgtaaaagt cttccatcga tacgggtggt tgacactaaa 226741 ggagggagat gacaaaatga aattagttcc aagattcaga aaacaatggt tcgcttactt 226801 aacggttttg tgtttggctt tggcagcagc ggtttctttt ggcgtaccgg caaaagcggc 226861 agagaacccg caaacttctg tatcgaatac cggtaaagaa gctgatgcta cgaaaaacca 226921 aacgtcaaaa gcagatcagg tttccgcccc ttatgaggga accggaaaaa caagtaaatc 226981 gttatacggc ggccaaacgg aactggaaaa aaacattcaa accttacagc cttcgagcat 227041 tatcggaact gatgaacgca ccagaatctc cagcacgaca tcttttccat atagagcaac 227101 cgttcaactg tcaatcaagt atcccaacac ttcaagcact tatggatgta ccggattttt 227161 agtcaatcca aatacagtcg tcacggctgg acattgtgtg tacagccagg atcatggatg 227221 ggcttcgacg ataaccgccg cgccgggccg caatggttcg tcatatccgt acggtactta 227281 ttcaggcacg atgttttact ccgtcaaagg atggacggaa agcaaagaca ccaactatga 227341 ttacggagct attaaattaa acggttctcc tggaaacacg gttggctggt acggctaccg 227401 gactacaaac agcagcagtc ccgtgggcct ttcctcgtca gtgacaggat tcccatgtga 227461 caaaaccttt ggcacgatgt ggtctgatac aaagccgatt cgctccgctg aaacgtataa 227521 gctgacctat acaaccgata cgtacggctg ccaaagcggc tcgcctgttt atcgaaacta 227581 cagtgataca gggcagacag ctattgccat tcacacgaac ggaggatcgt catataactt 227641 gggaacaagg gtgacgaacg atgtattcaa caatattcaa tattgggcaa atcaataaat 227701 acagcaaact agccatattc atgtctattt tgtttttatg cgggtgcagt tcgcagacgc 227761 attcttctca aaaagaaacg actattcctg tcactcttca tgtggaggat gctaaggggc 227821 tgccggtcga aggggttcaa gtgacgattg tcaaagcgcc ctcttcagat gaggagccga 227881 gtacagagat tggcgagata ctcggtaaaa cagacaaaaa cggagatatc aaatgggata 227941 ccggcagaaa aggcgattac tcagtcgcgt tgacgaaggg tgaaacatca gtaacccatc 228001 acatctcgtt aacagaggat aaaaaagatc atgccattcc attagtcttc aaagaatagc 228061 agtttccttg attttaaggg aactgccttt tttatttatt gcaggaaacc aaactatata 228121 ctggaaattt attatgtgag ataataagaa ataggtattt tttcttacga gacaaaaggg 228181 gcgttatcct ttatatcaat caaacccgga ggaaaaagaa gaagatgata caagattcaa 228241 tgcagtttgc cgcggttgaa agtggtctgc gcttttacca ggcatatgat caaagccttt 228301 ctttgtggcc gattgagtcg gaagcattct atgtttctac tcgttttgga aaaacacata 228361 tcattgcaag tgggccaaag gacgcacctt cgctcatttt gcttcacgga ggccttttca 228421 gctctgcgat gtggtatccg aatatcgcag cgtggagcag tcaatttcgt acatatgcgg 228481 tcgatataat aggagacaaa aataaaagta taccatcagc agccatggaa acgagagctg 228541 attttgcaga atggatgaaa gatgtctttg attctcttgg acttgagacg gcacatctgg 228601 ccggcctttc gcttggcggg tcccatatcg tgaatttctt actccgcgcg cctgaaagag 228661 tagagcgggc ggttgttatc agtcccgctg aagcgtttat ttcatttcat ccggatgtct 228721 ataaatacgc tgcagagctt acaggggcaa gaggagctga atcatatatc aagtggatca 228781 caggcgacag ttatgatctg catcctttac tgcaaagaca aattgtggcg ggcgtggaat 228841 ggcaggatga gcaaaggagc ctgaagccga cagaaaacgg ctttccgtac gtgttcacag 228901 accaggaatt gaaatcaata caagtcccgg tacttctgat gttcggtgag cacgaggcta 228961 tgtaccatca gcaaatggcc tttgagcggg cttcggtatt ggtgccggga attcaggctg 229021 aaatcgtaaa gaacgccgga catctgttat ctctggagca gccagagtac gtcaatcaac 229081 gcgtcttgtc ctttttatgc ggggggataa aatagtaagg aacatgaaaa gattggcatt 229141 catttttcaa aaggtaacaa atgttgtata ataatagaat ttgaatgctg ctttttttgg 229201 gagcattcta tgttatcatg cttattggag aaaaattttt cctgtaacgc tattcgatca 229261 ctatcgtcaa ataatataga tggttttaca attggaggtt tggttacact gtgaattaca 229321 tcccctgtat gattacgata ggaaacttca tttgcggatt gctggcgatt cattccttgc 229381 tatatcacaa cattcattca gcagtgcttt ttatttttac aggcatgttc cttgatttct 229441 ttgacgggat ggctgctcgt aagctgaatg ccgtttctga tatggggaga gaactggatt 229501 cgtttgccga tctggttacg tttggggtgg ctccttctat gcttgcttac agtgtcgcgt 229561 tgtataccct gccatttatc gggatcttat gcgcattgac gtacagcatt tgcggaatgc 229621 ttcgcctctc taaatttaac attgaacaaa gcaagctccc gacgtttatc ggtatgccga 229681 ttccgtttgc gggcatgtgt ctcgttattc taagcttcac ctataacccg atccttctgg 229741 caatcggcac ttgcggactc tcatatttga tggtgagtaa aataaaattc cctcatttta 229801 aaaaacatgc ggcagaaaac ctggagtctg ggagatggaa ttagttcagc agctcatagc 229861 ggattacggt tatctcgcta tttttttgat gctggtatta ggaattgtag gattgccgat 229921 tccagatgaa gtgatgatga ccgttgttgg ctatttcacg cataccgatg tattgaatta 229981 tgagctttcg atattgatta gttttgtcgg ggctttgtta ggtatgctga tcagctacat 230041 gattggcaga aaagccggac gcccgtttat cgacaagtac ggcaagtggg tcggcttaaa 230101 agaaaaaaga atgatgaaag tggaaaaatg gatgaagaaa tacggtccat attctcttat 230161 tttaggttat tttattcccg gcgtcagaca tgtgacgtgc tacttttcgg ggatcggcaa 230221 aatggatctg aaaacgtatg ttgcgtttgc tgcaatcggc gcctttttat ggtgctttgt 230281 ttttattaca atcggaaggg ttatagggat tattcatgtt taatacggct gtaaagattc 230341 tgtatcgatc attgatagag ctgacgaatc atcgtctgtc atcctatctg attaaaggat 230401 tttgcgagtc gaaaatcagc aaaccggtca ttccgctttt ctcaaaacat tttcggctga 230461 attgggatga tgtggacggt acggctgctg attacggatc gctgtccgaa ttgttcattc 230521 gacaaataaa tctggagcgg cgccctgtgt caaaagaggc gcatgcggtg gtcagccctg 230581 ttgacggtgt ggttcagacg gtaggaatca tcaacccgaa tcaaaccttt acggtgaagg 230641 gaaaagatta ctcattcgct gagctgaccg gctgtaaaag cgcagaccat caatacaacg 230701 gcggatattt cgtcgtgctg tatttaagcc cgaggcatta tcaccgtttc cattctccga 230761 tcagctgcag gtatcaaaag ctggccgagc tcggaaatcg ctcatacccg gtaaatcaac 230821 taggcttaaa atacgggaaa gatgtgctgt cgaaaaatta tcggtttgtg tacgagctga 230881 atagcggcag ccgaaatgtc ctgatgattc ctgtcggcgc gatgaatatt aattctatcg 230941 tgcagacgaa tacccgtact gaattggaga tcggcgagga gctgggatac ttttcatttg 231001 gctcaaccgt cattttggtt tttgaaaaag acgcgttcca gccgtccgcc catttagcag 231061 aaggccaaga agtccaagtc ggagaactga taggttacga agaataaaaa gaggagcttg 231121 cataaacgca gcgcctcttt ttttgaagaa aggtgagatt catggagaaa caaatcatca 231181 gctggattac agattatcag aacaccggag atgaagccgt cctgcggcaa gtgcgagaag 231241 tgtgctggcc gatcgttgaa gcggttttgc aagagaaagt aatggatgat gaacaagcga 231301 acaatttgcg cgaaaaagga atcgagcggt ttccattcat catcagcaaa taccaagcgg 231361 atgtgcagct tccggttgag acatttttac aaaatacgta tcggttttac tttcatcagg 231421 tgatgagaga atccagctaa agcttctttc aacagagaag cttttttttg ttggcaggaa 231481 aaggaaactt tttctatatc tatctcgtaa tgactagaga acctagcaga aaaggagaga 231541 tagaattgaa acgaatgata gtgagaatga ccctgccgct gctgatcgtt tgtctggcgt 231601 tttcttcttt ttcagcctca gcccgtgctg cttctgaaga aaaatattgg gatcactgga 231661 ttgaacgaca tgcacagcct ctggatgctt ccaatgcttc aaacaaagac cttcgatttc 231721 taaaaaaggt gctgaaggga aaacgaatcg ttcagttagg agaaaccaca cacggtgctg 231781 gcgaaatcaa tgccacaaag gtcagaatga tcaaatacct ccacgaagag ctgggatacg 231841 atgtattggc ctttgaatcc ggctttcctg atacaaatgc atcctacctt aatatggacc 231901 aattaacccc taaaagcacg atgaaaaact ccatttacgc tgtatggcac acagaagatg 231961 tcgtcgaatt gtttgattac atgaaagagc aaaaagagaa aggcgatccg ctgatcctta 232021 ccggttttga tattcaaagc atgaagaatt cattcaatgt agctgcgact caatgggtaa 232081 aagcggtgga ccctgagaaa gcagagttgc tctcccaatc agaaaatgat ttttcaacat 232141 tagtgacaga cagcaatacg tttgatgaat tttcgcaaaa gaaggaaaag cttgtgaaaa 232201 actatcagaa gctgatcaag ttcactaaaa cacatgcttc agagctaaaa gaaaaccttc 232261 caaaagagcc gaaagcttat gagatgttta tgcattctct tcagctgaga attgacgtaa 232321 tggaaacata tatgctggaa gaaatgaaag aaaaactaga ggagtatccg gagaatattg 232381 aggatttttc attctttatg agagaccgca tgatggctga acaatttcag tgggtagccg 232441 acacccttta tccgaaaaag aaaatcattg tctggggcca caattaccat ctacgcaaac 232501 agaatacgaa gatgataaag gactgggtac agctaaacgg ccctaacatg ggtgattatt 232561 tgccggagcg gctgaaaaaa caaacatata cgattggcat ttatgcttac tcaggtgcga 232621 gtcttgatag ctccgataat aagactgtta agccggttac aagcccgccg ccgtctggga 232681 gccttgaagc tttgctgaaa gcggcggacc gaccggctgt ttttgttgat tttctccata 232741 caaaaaacaa gaaaggcact tcgtggatgt ataccccgcg gactgcgctc tattgggggt 232801 acatggaaga gcagatgatc ctgaaggaac aatatgacgg tgtcatttgg ctggagcata 232861 tcacgccctc tgtcattatc aagtgagcgg tgtcccctgt ggtaaacagg ggatttttac 232921 atatcgcaaa aataatcaaa acatataatc cgtgatccat tattctaaaa cagaaaggag 232981 attggagcgt gcaatgtatt atgaaaaagc tgtccagaaa acaatcaatt ggattgaatc 233041 acatttacat gagcaaatat caaacgagga tattgttaac gtttcaagct tttcaaaatt 233101 ccattttcat cggatttttc aaaaagaagt cggcatgtcg gttgcttctt atattcggtt 233161 aagacgtctt gcgaatgcgg cggcagcttt gctttataca gatcatcgta ttatcgatat 233221 tgctttgtat tatcagtttg aatctcaaga agcatttacg aggacgttca aaaagatgta 233281 tcacatgccg ccaggagcat accgaacatt tatgaaacgc tttacttcaa aaaaggagga 233341 atcttacatg gagaaaaaaa tgaaaggctg ggtattgagc gggagccatc cgttccaatt 233401 cgaaatgggg attgaccggg aaaatgtaca tcagggaaaa gcttcagggt atttaaagtc 233461 aacgatggtt caggatatcg gtgaatttgc gacgatgatg cagcaattca aagcagatcg 233521 ctatctagga aaaaggcttc gtctatcaag ttttatcaaa acaaaggggg tgcagcattt 233581 tgcctcactt tggatgcggg ttgacagtgc tgctgatgat gttctccaat ttgataatat 233641 gagcaacaga cctattaccg gaacaaccaa ttggaatcat tatgctatcg ttttagatgt 233701 cccagaaaat agcgctgtga tatcttttgg cgttcaatta tctgggccgg gtcaggtgtg 233761 gatggatcat gttgtttttg aagaggtaga tgagagcgtt ccttcaacaa accttgaaat 233821 gccgggagaa cttttagatg aaccggtaaa tttatctttt gaagaggaac tacaaaaata 233881 gttttcagac aactactttt attagtgagt taatggaaaa tactatttgt tattaataaa 233941 cccttgtgct gcttaggttt gtaagagctt ggatattttt atcagtctgg gcggatctgt 234001 tcatctttgc ggcattttcc tgtatgatat agtaagagtg tgcatagcaa ctaactataa 234061 ttgaacaggg tgtttaaaac atggaaaaac aatacagagt attactttac tataaatatg 234121 ttccgattga agatccagag gcgtttagag agcagcatct ggctttttgt aaggagcttg 234181 gtttgttagg ccgtatcctt gtttcttctg aaggaattaa cggtacggta tcaggtacgg 234241 ttgaacagac tgaaaaatat atggaaacaa tgaaagctga tcctcgcttt gcggacatgg 234301 tatttaaaat tgatgaagca gaaggccatg ccttcaaaaa aatcttcgtc cgccataaaa 234361 aagagcttgt aacgcttcgt cttgaagatg atgtcgatcc gaacgaaaca acaggccagc 234421 atttgaagcc tgcagaattt tatgagaaga tgcaggatcc aaacacaatt gtcatcgacg 234481 cgcgtaacga ttacgagtat gaccttggcc atttcagagg tgcggtccgt cctgacatcg 234541 aagccttccg tgaattacct gaatggattg aagagcacaa agatatgctt gaaggcaaaa 234601 agattttaac gtactgtaca ggcggcgtgc gctgtgaaaa gttctcagga tggctggtga 234661 agcaaggctt tgaagatgta gctcagcttg atggcggaat cgtgacatac ggaaaagatc 234721 cagaggtgca aggcaagctt tgggacggcc agtgctacgt atttgatgaa agaatcagcg 234781 tgcctgtcaa ccgtgtcgag catgtgattg tcggcaagga ctactttaca ggagaaccgt 234841 gtgagcgtta tgtgaactgc gcaaatccat cttgcaataa aaaaatgata tgcacaccgg 234901 aaaatgagta taaatatatg cgcagctgca gccacgaatg ccgcacgaac ccaagaaacc 234961 tgtatgtgaa agagcataat atgacagaag aagaagtaaa cgcaagactg gcagcgattg 235021 aaacagaaga tcacgctgct gctgaataaa aaaagaacac ctcgtattga ggtgttcttt 235081 ttttctatat gctttcagtt tggctgtttg cggaaaccca ttctttttgg cggaaggcct 235141 tttcccattt tgataccacg atacaggcga tcgcatgtcc cggtacgttc acgcctgttc 235201 tcgccatgtc catgacgcgg tcaacacccg cgataatggc aacgccttca gccggcagtc 235261 ctacagcatt ggcagtcgcc agaagaacta caagcgatcc tgagggtaca gctgcaatgc 235321 ctttactggt catcacaagc acaagcatca tgagcagctg ctgggacaat gtcatgtcta 235381 cttgaaaggc ctgtgcgaga aagatacaag aaaccgataa atataagctg gagccgtcac 235441 agttcaatga caagccggag ggaacgacaa atgataccac tcgtttggga cagccgtatt 235501 tctccattct atccatcagc tgagggagaa tggtttcagt gcttgtggtg gaaaatgcaa 235561 ttaaaaacag atcccatatc attttcaata cttcgaaata cttaatctga aagatgagac 235621 cgacaagcgg aaagaggaca aagaggatca ggaacaggcc aaggaatacg gtgccaacca 235681 gcttaaacat agggaggagg agttcaatgc catattggcc tacagaagca gccatcaggg 235741 ctaacacgcc gataggagca gtgaccatga cgatttgcgt gagcttgaac ataatctgag 235801 ctgtagattc aaaaaacttc attactggtt cagaagcttt gccgatacca gctgcggcga 235861 caccaaataa aatggcgaag aaaataacgg caagcaaatc atttctggcc atgacatcaa 235921 taatgtttgt agggataata tccaggatca tttgcttgaa atcaacaact ttgtctgtgt 235981 agccggaaag ttcatgaata tctttttttg ccaaatggga gaggtcaagc ccgacacctg 236041 gttttaagac attcgctaat aaaagtccaa gccctaatac caacgttgta atcacttcga 236101 accaaatgat cgtcttgatg ccgagactgc ccattttttt catgcttccg cttcctgcgg 236161 ctccaatgac aatggtagaa aatacaatcg gcacaacaat cattttaatc aggcggataa 236221 atccatctcc gacaggcctc agtgccatcc cgaaatcagg aaaaaagtgg ccgatcaccg 236281 cgccgacagc caaagcgatt aaaatttgaa acgcgattaa ttttttcaaa tgaatccccc 236341 tttagaacga tagaatgtag gcatattcat atcattcgtg attcaaatgc aaacaccttt 236401 tttcaagtta ttttattttg acagcgcttt cattatgttg gcgaaaaagt cccccgcagc 236461 aggggggact tttttacttc atttgaatgt gctttagatc ttcttcagag gtatttgtga 236521 aaataaccgg tgttatggct gaagcggcat gctgcttgat gtaattgaga tcaaaggtga 236581 gaagcagttc gccttgtttg acggcttgtc cgcttgtgac atgtgcttca aagccttccc 236641 cattcagttt gacggtatcg atgccgacat gaatcaggat ttcagtgccg ccggcgctca 236701 taaagccgat ggcgtgtttt gtcggaaaaa tcgagacgat ctcgccgtcc gcaggtgcaa 236761 cgacttttcc ttctgatggt ataatcgcaa atccctcgcc catcattttt tctgaaaaga 236821 cctgatcagg cacatcccct aaagagactg tttctccttt aatcggataa ataaaggtct 236881 catcggaatc gggcttcagc ggtttgtcag ttaccgtgtc cagcgcggcg gcggtggcag 236941 ggacgcctcc ggccatgatt gttttgatgt cgtcttttaa ggcatcggac ttggttccga 237001 atattgcctg gaagttgttg ttgacctcca gcacacctac tgcaccaagc cgttttaatt 237061 catccttgca gacttggctt ggctgatgaa cggtcacacg aagccttgtg atacatgcat 237121 ccaggttagc gatattttgc tgtccgccca aggcctgcag cacgtgaaag gcaagctggt 237181 cttttgcaac tggagctttc tcctcattct gaccgtcttc atctgtctca cggccgggcg 237241 ttttcaaatt ccatttcaga atcgcaaatc ggaacaaata ataataaatg aaagcaaaca 237301 cgatcccgac aggaatgaca acccagccgt ttgtagacag tccgtagttc aagacgtagt 237361 caattcctcc gcctgagaac gtatagccgt ggcggacatg gaataaatca caaacgacaa 237421 agatgacgcc ggcaagaata gagttaatca aatagagcac gggcgcaacg aacaagaaag 237481 aaaactcaac cggttctgta attccggtca gcatagatgt gagcgccgca gaaatcatca 237541 cgccggagat catttttttc ttttccggac gcgcggtatg gataatggca agagcaacgg 237601 ccggcagaca gaaaatcatg taagggaaat cccccatcat aaagcgcccg gctgtcgggt 237661 ctcccgcgaa aaaccttgtc aggtcgccgg ttacggtgtt gcctgttgat gggtctgtgt 237721 attctcccat cataaaatag aaaggcgtat aaaaaatatg atgcaggcca aaaggaatca 237781 gcaaacgata gatcgttgca taaaagaaca ggccgactgt tgaatcggca attaaactgc 237841 tggctgcgtt aattccgttt tggatcagcg gccaaacgaa tgagaaaatg acgccgatca 237901 ccaatgaact gacggaagta atgatcggga caaagcgttt tccagagaaa aatccaagga 237961 ccggatgcag ctcgattgat gaaaatcgct tatataaata ggcggcgaga agcccgataa 238021 tgattcctcc gaaaaccccc atatcaatca ggtgctcggc tccttcatac ggaggctgaa 238081 ggccgagtaa ttttcccata ttgtcgaggg tgacggttaa aattaagtat ccgatgacag 238141 cggcaagtcc ggctacacct tctccgccgg ctaatccgat cgcgaccccc acggcgaaaa 238201 tcagcggaag gttatcgaat acaacgccgc ccgcatcctt tataataggg atgttcagta 238261 aatccttgtc tccgaaacgg agcaaaagac ctgctgccgg caggacggca accggagtca 238321 tcaacgcgcg gccaagctgc tgcagaattt gaaatgcctt tttaaacatg acagtctcct 238381 tttattgtgt tatgagaatg atgcactctt taatttttga gctgctttat aatcggcgat 238441 aacggttaca tgattgtgtt tttgaagaat ggaggctggt acatctgtcg tgacaggacc 238501 ttcagccatc ttttgaatgg cgtctgcttt ttcctcgccg cttgctaaaa gcacaatatg 238561 tttgctgaat tccatgatgg ttttaatgcc cattgaaatc gcgagtctcg gaaccagcac 238621 cggatcgccg ccgaagaatc tggcatttgc ctgtatcgtg ctttccgaga gcttcacaac 238681 acgtgtccgg tcttcaaaat cagatcccgg ttcattaaaa ccgatatggc cattggcgcc 238741 gatgccgaga atttggacat caatgcctcc cgcctggcgg atgagatcct cgtatacttt 238801 gcatgccgcc tcaagctgcg gattgtctcc ttgcgggata tgaatatgat caggctgcat 238861 attgatatgc tgaaaaagat gctcatgcat aaaatggtta taactttgcg gatgagatgg 238921 agagagacca gcatattcat ccaaattaaa tgtagtaacc tttgaaaaat caatttcgcc 238981 tgcctgatag tctgaaatca actgcttata caagccgacc ggtgtgcttc ctgttgccag 239041 gccgagaacg gcatctttct tagcttgtat ttgttcttta ataatggcag cgcttaactt 239101 acagagttct tcgtagtgct cggcgatcag aatcttcatg tgacaccccc tcaaagagat 239161 agacaagcac catatttgtt atgaccaatt tatgatactt gtcattacga atttagcacc 239221 gcccttatca aactgtcaat attaatttct gaaaatttgt tataaaagaa ggatacaaat 239281 ctttcatatt gggagggcaa atggtattat ggtctcaatg aaaaagaacg gattgcatac 239341 agaatgggga gaatgaaatg acagctttat attctgttat caagtttaaa atcattgagt 239401 taattaaatc gggcaaatat caggcgaatg atcagctgcc gacggagagt gagttttgcg 239461 aacaatatga tgtcagcaga acaactgtga gactggctct gcagcagcta gagcttgagg 239521 gatatattaa aagaattcaa ggaaaaggga catttgtatc ggcggccaaa atacaaacgc 239581 cgattccgca taagattacg agctttgcag aacaaatgag aggacttcgt tctgaatcaa 239641 aagtgcttga gcttgtggtg attcctgccg atcattccat cgccgagctt ttgaaaatga 239701 aagagaatga acctgtcaac aagcttgtca gagtcagata cgccgagggg gaacctttgc 239761 agtatcatac ctcatatatt ccctggaagg cggcaccggg gctggcgcag gaggaatgca 239821 ccggctcgct gtttgaattg ttaaggacaa aatacaatat tgaaatcagc aggggcacgg 239881 aatcgatcga accgatttta acggatgaaa cgatcagcgg acacttatta accaatgtcg 239941 gagcgcctgc gtttttatca gaatccctta cctatgataa aaatgaagaa gtggtggaat 240001 atgcgcaaat tattacacgg ggagaccgaa cgaaattcac cgtagaacag tcatatcatt 240061 cataaagcaa tgtgttttaa gaagggaatg gtggttctat gtttttattt acgaatggaa 240121 aagtgctgtg gggagcagtg attgctgcat tcatcctttc aattgtattt tacccttttc 240181 tgccgacgca gatgccgatt cattatgatg ttgcgaacag tccggatctg acggttaaca 240241 agctggcggg gactgtgatg ctgcctgttt tgatggtggt gtttgcatgg gcgcggaaga 240301 tcaattggca atttgtattc gcagtgtata ttttgctgat ttgccacatt gtcgtccttt 240361 gtttagcgct ctaaatcaaa cagccagaat aaaactggct gttttcttta atttcagctt 240421 catctgacaa tgaatgtggt gtataatagc tgatgatcct aaagaatatt ctgaaattta 240481 taggtgtgaa gcggcgtatt attaaaggaa aggctgtata ctttttgcag ctttaaaaag 240541 actgaatatt taaacaatta tgtgaaaggt gtgctgatta gattgaataa gcttattgaa 240601 cgagaaaaaa ctgtatatta taaggaaaag cccgacccgt cttccttggg gtttggacaa 240661 tattttacag attatatgtt tgtgatggac tacgaagagg ggattggatg gcatcatccg 240721 agaattgcgc cgtacgcacc gcttacgctt gatccgtctt catctgtttt tcattacggc 240781 caggctgttt ttgaaggatt aaaagcatac agaacagacg acggcagggt gctgctgttc 240841 cgtccggatc aaaatatcaa acggctgaac agatcgtgtg agcgcatgag catgccccct 240901 ttagacgaag agctggtgct tgaggcattg acgcaattag ttgagctgga gaaagattgg 240961 gttccaaagg aaaaaggaac gtcactgtat attcgtcctt ttgtcattgc cacagaaccg 241021 agtctcggtg tgaaggcatc caggagctat acatttatga tcgtgctttc gcctgtcggc 241081 tcctattatg gcgacgatca gctgaagccg gttagaatct atgtcgaaga tgagtatgtg 241141 agggcggtca acggaggagt cgggtttgca aaaacggctg gaaactatgc cgccagtctt 241201 caggcacagc ggaaagcgaa tgaactgggc tatgaccagg tactgtggct ggacgccatc 241261 gaaaagaaat atgtggaaga agtagggagc atgaacatct ttttcgtcat aaacggggaa 241321 gctgtcacac ctgctttaag cggaagcatt ttaagcgggg ttacacgtgc gtctgcgatt 241381 gaattgattc gaagctgggg cattccggtt cgtgaagaga gaatatcgat tgatgaggtg 241441 tatgcggcct ctgcacgcgg agaattgaca gaggtctttg gcacaggcac ggcagcagtc 241501 gttacgcctg tcggtgaact caacatccat ggaaaaacgg tgattgtagg cgacgggcaa 241561 atcggggacc tctcgaaaaa gctgtatgaa acgataacag atattcagct tggcaaggta 241621 aaaggcccgt ttaactggac agtggaagtg tgaaaatcga aaaagaacct gcccggaggc 241681 aggttctttt tattttgaat gagtcatatc agcagccggc tggcttttgc ggttttttac 241741 ataatatatt gcatagcaaa tggccataaa tggaacgccg caatagagtg cgattctttg 241801 attcggatca aaggcaatgc caacgacgga agccaggcat aacaggaacg cagcaatcgg 241861 cacgaacgga tacaaagggg ttctgtattt caaatcagta accttgtttc ccgcttcgat 241921 ataacgtttt ctgaacatga attgagaagc agcgattccc atccacacga caacgacggc 241981 aaaaccggaa atcgacacga gcacaacgta tacagtgtct ggcgcaaata cgctggacag 242041 caacgacaga atgccgccga tcatgctgaa caccagcgcg ttaaaagggg ttccttttga 242101 cgtcagcttt gcaaatgtcg gatgaagcgt tttttctttt gataaagacc acagcatccg 242161 ggaagaagcg tagagtccgg aattagccgc tgacaggatc gctgtcagga taacaaagtt 242221 catgatatcg gctgcgtatg gtacaccgac tctgtcaaag acagcgacaa acgggctttt 242281 gatgacacct gcatcttgaa tcggaatcag ccctgacagc acaaaaattg ttccgacaaa 242341 gaagagcgag agacgccaga ccgttgtttt tatcgctttt ggtatcgtct tgtcaggatc 242401 aacgctttca ccggctgcga ttccgattag ttccgttccc gaaaaggcaa aattgacgga 242461 cagcatcgtc atcaaaatcg ggacaaatcc attgggaaaa agcccgcctt ccgccgtgaa 242521 gttggacagc atcggagcgg cttctccgcc tttgatcggg atgatgccga acatggcaga 242581 gccgcctaaa agaataaata atacaatggc taatactttg atgctggaaa accaaaattc 242641 tgattcagcg aaaaacttga ccgaaaatgc gttaagcaag aagatgaaca gcgcaaagac 242701 ggcactccac atccaaaccg atgtatgggg gaaccagcgc tgcattaaca ggccggctgc 242761 tgtgaattct gatcccaatg ccacggtcca tgtcagccaa tacagccaag cgaccgtaaa 242821 tccggtgccc ggccctatgt atttggctgc ataggtgtga aaggcgccgg tcacaggcat 242881 ggcgactgac agctcaccga ggcatagcat gaccagatag acgatgccgg ccccgactaa 242941 gtaggcgagt atcgttccgg ccgggcctgc ttgctgaatg gtataacctg agcttaaaaa 243001 cagcccggtt ccgatgacac ctcccaagga aagcataaag aggtgccggc ttttcatact 243061 tctctgaaag gttgtctcat tcttgttgtg ggcagagttc atctttttcc aactttctat 243121 cagcgattta tttccttcct aataaaaaat ctcatgtcag aaagtgacac gagactccgg 243181 cgaaccggct ttaagttaga atatacaaac tattccgata agtcaagttg tttttaaaga 243241 gcgggcccaa gccgcaattt cttgaatatt ttcgggtttt gtccggcagc agccgccaat 243301 cagcctcgct cctttttcat gccaggtgcg ggcgctcgcc ccgtaagatt ctgcgcatgc 243361 tgcgccgttc cacgtttttg tttccggatc atattgctca cctgaattcg ggtagacaat 243421 gatcggtttt gacgtgttct tttttaactc ctctatcaag gaagggatat gctgaagcgg 243481 cgtgcagttg atgccgagtg ctgcaatttg gcggtgttca tcaagccacg atgcgcagtc 243541 agctgcaggt gttccgtcac tgatatgcaa gccgtcttta gcactgaagc tgatccatgc 243601 atacgtttca ggaaattcct tcaacagccg aacaatcgct ttggcttcag tcagacacgg 243661 aatcgtttcg catgccaata catcagctcc ggcttcaatc agcgccttca tccgggggcg 243721 atgaaattca atcagttcat cttctgatat tgcgtagttg ccgcgatact cagacccgtc 243781 tgcaagataa gcgccataag ggcctataga agccgcaatg atcggttttg gccgattcaa 243841 acggttctct tcaagcgacc aaaattcatc acgtgcttca gctgcgatgc tgacggacaa 243901 ctcgatgagc cggcgtgctt ccgcttcgct cagcccgcgt gcggcaaagc cttcaaatgt 243961 agactgatag ctggcggtga ttgcacaatc ggcgcctgcc gcaaaataat cagtatgaac 244021 ttgtttaatc agctccggct cttccatcag gatttttgcc gaccacagac tgtcattcaa 244081 attacagccc ttgcgttcaa gctcggtcgc catggcgccg tctagcacaa taagcgggta 244141 tgtatctaat atgtgttgga taggattcat agaatgtacc gatgccttct ttcagatttt 244201 tttgaaaaag atatgaaaat cgtaatggag gcttacgtgt ttgtcaataa acgcaaaaag 244261 agaaaggtgt tcagcccata tgtctgaaca cccttttctt atgatatttg tttgttgtgc 244321 gtgtcagtct ttgtgtctga aaccggccag cactcaatgc cattatggtt tttgagcaca 244381 tctttataaa agaccggatc cttgcctgct tttttctggc gtgtatagtc tttcagcgcc 244441 gtaaaaacga cctttgatag taagaaaatc gcgattaaat tcacgatgac catcaaaccc 244501 atgaacaaat cagcaagatc ccagacgagc tggactttgg caacacagcc aaacacgatc 244561 attgccagca cgccgatacg gtagacaaaa atcagttttt tgcttttgtt caaaaagccg 244621 atattggttt cgccataata atagtttcca attagagcac agaatccgaa taacaaaatc 244681 agaatcgcga gaaagcctga tgcccatgat ccgacatggg agctgaggga ggcttgtgtc 244741 aaggcgattc cgctcagacc cggagtatga taggcatccg aaaacagaat gataaaagcg 244801 gtgcttgtac aaatgaccag tgtatctgtc agtacaccaa aagcttggat cagcccctgt 244861 ttgacgggat ggcttgttgt ggcggtggca gcggcatttg gtgcgcttcc cattcccgct 244921 tcgtttgaaa agattccccg tctgacgcct tgcatgagtg ccgcgcccaa agccccgccg 244981 gcggcctggt caaaaccaaa cgcatttttc acgattagcg caagcacacc tggcagctgc 245041 gtaatgttgg agaaaatgac gaaaaacgca actccgatat acaggacagc caatacgacg 245101 acaatggatt cagccagctt tgcaatgcgc ttgactccgc caaaaataat cgtgccgaat 245161 acagcaatta aaatgagtcc caatgtcagg cggtttgtgc caaacgcgtt ttcaaaggca 245221 aggctgactg tattggattg aaccgagttg aagacgatac cgaacgataa ggtgattaac 245281 acagcgaaca gcgcgcccat ccaccttttg ttcagccctt tttccatgta atacgccggc 245341 ccgccgcgga agccgtttac atcttttact ttataaatct gagccagtgt gctttccaca 245401 aagctggatg ctgatccgat aatggcgata atccacatcc agaagattgc accgggcccg 245461 ccgagtgcaa tggcgatagc aatgcccgta atatttcccg ttccgacacg ggccgccatg 245521 ctgatgcaaa aggcttgaaa cggagaaatg ctgttttttg accgggaagc agcaccttct 245581 cttaataccc tgaccatttc tttcagcatg cgaacctgta aaaacttaag cctgaacgta 245641 aaatagattc caaaagaaag gagcaaaaca attaatagct ttgaccacaa aagatcattt 245701 gcaataccga cgatatgttc taggatttgc tgcatagaat cacctctttt ttcatgttta 245761 aaaaatgctg agctcccatt cctgcgccat atgcttcagc agcataccgc cagtgaggct 245821 gttgccgtat tcatcaatgg caggcccgta aatgccgatg ccgcatccgg attgaaaagg 245881 ctgttctctt ctggcgcttg gaggcaccag cgccatgatg ccgccggaga cgccgctttt 245941 ggccggcacg ccgacaaacg ccgcatattt gcctgaagcg ttgtacatgc cgcacgtcag 246001 cattaatgcc ttggccaatt ttgccacatc ttttggaatc acctgctcgt gtcgaatcgg 246061 atgatacccg tcatgagcaa ggatcaggcc gatcaacgca atatcttctg tagtgctctc 246121 catagcgcat tgcttcaagt acacctcaag tgtttcttct acttcagctt ctaaaaagtt 246181 tgtttctttt aaatagtagg ccagcgctct gttgcggtgg gcggtttccc attcagaacg 246241 gaatacttct tcatgaattc ttggccgttt tcctatcaaa gtttccatca ccgagtaaag 246301 aaactcgagc ttttcgtatg cagattctcc gggaaggatc gaagcgatgg tgagggcacc 246361 cgcgttgatc atgggattga agggctttcc cggcttgttg atttcgagcc gaatgattga 246421 attaaaggcg tcacctgtcg gctcgacatc tacgcggtca agcacatagg gaatgccgcg 246481 gctcatgcag gcggcaataa agctaatcac ttttgaaatg ctttgcatgg taaaagagac 246541 gttccagtcg ccggcgtgta tcatcgttcc atcaggctcc aatacacaga tgccgagctg 246601 tgaatcattg acttttccta aagcggggat atagtttgcg ctttgtccat tggcggcaaa 246661 agggcgatag tattcaaccc aatcatgaag ctgtaacgcc gggtttatgt ctttctggtg 246721 ctcttttatc aattctttca tcgaattcct cctcactgat ttttttctta aaggactgag 246781 gtgtatcaaa acgaaggcta agggggcgtt aaacgctttc ataatagcgg aaggtataat 246841 tactgtataa tggagactac agaatcatac aaaatacgac aaaaacattt tgaaaataag 246901 cagtaagatt tataaaaacc tcatgttctg ggtcaaaagc aatttgcagg ttttctcccg 246961 attccccaaa ataaaaagcg aggatgtgat caacataaaa ctggaacggt ttattgaaaa 247021 agacggatat atactggccc tcatgctgat tacggtgccg ctggccggtg aactgaaatt 247081 ttatcccctc aatgaagaat tccgggtcag ctttggggca ccggtttttt tcttcttttt 247141 atcattgttg cggcatgtgc ccgctgtgct gccgggtttt ctgactggag cggctgtttt 247201 catctttcgc gtctttctgg aattatgggg cggaggacac aatgggctga ctccgattct 247261 gtatgatcaa gcgtctggct ttttctttta tatgacttac gcctgtctgt tttccatatt 247321 aaaggccaat cgtttccgtg aacggccgat tatgctcggt ttcattgggt ttatgattga 247381 agttgtgtca gattgtgtcg agctaactgt gcaatttctc atttttcata cggttgtcac 247441 gcctgagaaa atcactgaca ttgcggtgat tgcgatttct cacacattta ttgtgatgag 247501 cttttatagt gtgctgaagc tgtatgaaac acaatcgaga gaaaaacaga caaggcagca 247561 gcacgagcac atgctgatga tcgtttccaa tttatatgaa gaaacggtgc acctaaaaaa 247621 gacattgaaa acgacagaga aagtgacaaa cgattcgtat cagctctatc gggaaatgaa 247681 gggcaaggat gttcagctga gcggcagaat cctgagactg gccggagaga ttcatgaagt 247741 gaaaaaggac aaccagcgga tattcgcagg gctttcaaaa ctgatttcga atgagagttt 247801 gagagattat atgagggctt ctgatttgct gcagctcgtg attcgaatga atgaaaagta 247861 cgctgaagca ctagggaagc agattgattt ttactgctcg atcgagggag agcatgacga 247921 atatcacgta tttatcgtgc tttcgatcat taataatcta acagcaaatg cggtagaggc 247981 tatggatgaa gagggaatgg tcagcctgag gctccgtaag ccaaatgaga gtatggtaga 248041 attccaggtg gaagacaatg gccccgggat ttccgagaaa atcggagaca ttgtgtttga 248101 cccgggcttt acttcaaaat atgacgaatt tggcacgcct tctacgggta tcggactttc 248161 ctacgtaaag gaaatcgtga cagagctaga aggggatatc acgtttgata atcagcagcg 248221 gggagtggtg tttgccatca ggctgcctgt ccggcatttg attcagaaag ggtgaaccaa 248281 aagctatgcg tttttttatt gcagatgatg accgtgcggt gcggtcaatt ttaaggcaga 248341 tcattgagga cgaagatctc ggggaagctg ctggtgaagc agacgacgga agccaagtgg 248401 aagggcatat gctgcaattt aagcagattg atattttatt aatcgatctg ttaatgcccg 248461 gaagagacgg cattgagacg attcgtcaga tccagaatac gtactccggc aaaatcgtaa 248521 tgatctctca agtggaggcg aaggaaatgg tcggggaagc gtactcgctc ggcatcgaat 248581 attttatcca taagccgatt aaccgcattg aaattgtcac ggttctccaa aaggtgaagg 248641 agcggatcga gcttgaacac tcgattggag ccattcagca ttctctaagc cggcttgtca 248701 atcggactga acggaaagcg cgtccccagc agaagagtga cagcggttta aaagaggcag 248761 gaacattcct gttgtccgag ctgggcatga tgggagaagg cggcgcacat gatctcatgg 248821 cggtcctgca gtatttagca gaacacgagc aatccgagcc gcacgaaaaa caaagccctt 248881 cgctaaaaca aatattcacc caagtagcgg tacggaagct ggggacagga gcctcacaga 248941 cggaagtcaa tcgcgaaatg aaagcctcgg agcagcgtat ccgcagagcg attattcatt 249001 cgctgcacca ttttgcttca ctgggcacaa ctgatttttc gaatccaaaa tttgaaacct 249061 atgcatcgaa attctttgat tttccggttg tcagccagaa aatgaaagaa ctccaatcca 249121 aggatgcaaa accccttgca cctgctagaa taaatatgaa aaaattcatc cacgtgtttt 249181 ttttggaagc aaagcttttg catgagacga tgaaacaaag aaggatataa accaaacagc 249241 cggctgacca ggctgttttt ttgctgcgca gaatcccggc cggacagtga tttaccgctt 249301 ttttataaaa tatcagaaaa taaagatatt gacttattgt ttatttgtct tacaattaaa 249361 caaaaggata tatgggaagg agcggatgtg aaagaaaaat taataaaagc gcttacagat 249421 agaggccgta tacacaaata acaggaggtt atgttgatga gccgtatcag aaaagcaccc 249481 gctggaattt taggttttcc ggttgctcct tttaacacac aaggaaaact ggaggaagaa 249541 gctctttttc aaaacattga gtttttgctg aatgagggct tggaagcgat atttatcgct 249601 tgcgggtctg gtgaattcca atctctcagc cagaaggaat atgagcaaat ggtggaagtc 249661 gcagtctcgg cagccggagg aaaggtgccg gtctacacgg gggtgggcgg caacctcagc 249721 acagcgcttg attgggcgca gctgtcggag aaaaaaggcg ccgacggcta cttgattctg 249781 cctccgtatt tggtgcatgg cgaacaggag gggctgtacc agtatgcgaa aacgattatt 249841 gaaagcactg acttgaacgc gattctttat cagcgcgata acgcagttct ctctgttgaa 249901 cagatcaaac gtctgaccga atgtgaacag cttgtcggtg tcaaagacgg ggtaggaaat 249961 atggatttga atatcaatct cgtctatacg atcggcgacc gcttgggatg gctcaacgga 250021 atgccgatgg ctgaagtgac gatgccggct tatctgccga tcgggttcca ctcttactct 250081 tcagcgattt caaattatat cccgcatatt tcgcgaatgt tctatgatgc attgaaaaac 250141 ggaaatgacg agcttgtgaa ggaactctat cggcatgtga ttctgccgat caacgacatt 250201 cgcaaacaac gaaaaggcta cgccgtatcc ttgattaaag ccggtatgga aatcatgggt 250261 ttgaatgtaa ggaatacagc cagaccgcct gtcggcccgg ttgaaaaaga tcattatcag 250321 caattggaag caattttgaa gcaggcggct gaccgttttc cgaaaaaagc cgcgacggtt 250381 tgaccagaaa aaacacgaaa ggggcaatgg gcatgtctgt gatcacggaa caaaacacgt 250441 acctcaactt tattaacgga gagtgggtta agtctcaatc aggcgatatg gtcaaagtcg 250501 aaaaccctgc cgatgtgaat gatattgtcg gatatgtaca gaattcaacg gctgaagatg 250561 tggaacgtgc cgtcaccgcc gccaatgaag ccaaaacggc ttggagaaag ctgacgggtg 250621 ccgagcgcgg ccaatactta tacaaaacag cggatatcat ggagcagcgc ttggaggaaa 250681 tcgccgcctg tgcaacgcgt gaaatgggta aaacattgcc ggaagcgaag ggagaaacag 250741 cccgggggat tgccattctg cgctattacg ccggagaggg catgcgaaaa acgggtgacg 250801 tcattccgtc tactgacaaa gacgcgctca tgtttaccac ccgtgttccg ctcggtgtgg 250861 tcggtgtgat ttctccgtgg aacttcccag tggcgattcc gatttggaaa atggcgccgg 250921 cattggtata cggcaatacc gttgtcatca aaccggcgac agaaacagct gtgacatgcg 250981 cgaagatcat tgcctgcttt gaggaagcgg ggctcccggc aggggtcatc aatttggtga 251041 caggcccggg ttctgttgtc gggcaggggc ttgctgagca tgacggtgta aacgccgtta 251101 cgtttaccgg ttcaaatcaa gtcggaaaaa tcatcgggca agccgcttta gcgaggggag 251161 ccaaatatca gcttgagatg ggcggcaaaa accctgtcat cgtagctgat gacgctgacc 251221 ttgaagctgc ggcagaagct gtcataacgg gggccttccg ttcaaccggc cagaaatgca 251281 ccgcgacaag ccgtgtcatc gtacaaagcg gaatttacga gcgctttaaa gaaaaactgc 251341 tccagcgcac aaaagatatt acaatcggag acagcttaaa agaggatgtc tggatgggac 251401 cgatagccag caagaatcag cttgataact gcctgtcata cattgagaaa ggcaaacagg 251461 agggcgcttc ccttttaata ggaggagaaa agctggagaa cggaaagtat caaaacggct 251521 attatgttca gcctgccatc tttgacaatg tgacatctga gatgacaatt gcccaggagg 251581 aaattttcgg tccggtgatc gccttgatca aggtggactc gatagaggag gcgctgaaca 251641 tcgccaatga tgtgaagttc ggtttaagtg catccatctt cacggaaaac atcggccgaa 251701 tgctttcttt cattgatgaa atcgatgccg ggctggttcg gatcaatgca gaaagcgcag 251761 gtgttgagct gcaggcgcct tttggcggca tgaagcagtc gagctcccac tcccgagaac 251821 agggtgaggc agcgaaggac tttttcacag cgatcaaaac tgtttttgtg aagccgtaat 251881 ggtgctggaa agaggcgtgc gtctctttcc cggtttatca caaccagcat atgattctct 251941 actttgaaaa ggagaagata ctatgaaaaa agactttgcg agtgttactc cggcgggcaa 252001 aaaaacgtcc gtgcgctggt tcatcgtgtt tatgctgttt cttgtgacct ctattaacta 252061 cgcggatcga gcgacgcttt ccatcaccgg agattccgtc cagcacgatt tgggattgga 252121 ctcggtcgcc atgggatatg tcttttctgc ctttggctgg gcctatgtca tcggacagct 252181 tccgggcggc tggctgctgg accgttttgg ttcaaagact atcattgcgt taagcatctt 252241 tttctggtcg ttttttacgt tgctgcaagg ggcgattggc tttttctccg ccggcacagc 252301 gattatcctg ctgtttgcac tgcgttttct ggttggttta tcagaagcgc cttcatttcc 252361 cggaaacggc agagttgttg cctcatggtt tccaagctcc gagcgcggga cagcttcagc 252421 cttttttaat tcagcacaat acttcgcaat cgtcattttt tctcctttaa tgggctggct 252481 tacccactct ttcggctggc attccgtttt cgttgtcatg ggtattgcag gcattcttct 252541 ggctgtcatc tggctaaaaa cggtgtatga accgaaaaaa catccgaagg ttaatgaagc 252601 tgagcttgcg tacatcgaac agggcggcgg gctgatttcc atggatgaca gtaaaagcaa 252661 acaagaaaca gaatcgaaat ggccgtatat caaacagctg ttaacgaacc gcatgctgat 252721 tggcgtgtac atcgcgcaat actgtattac gactctcacc tatttctttc tcacatggtt 252781 tccggtatat ttggttcagg cccgcggcat gtctattctt gaagctgggt ttgtcgcttc 252841 cctgccggcg ctgtgcggat ttgccggcgg cgtgcttggg ggcattgtgt cagacatctt 252901 actcaaaaaa ggccgttcac tgacctttgc aagaaaagtg ccaatcattg ccggcatgct 252961 gctgtcttgc agtatgattg tctgtaacta cacagattca gcatggctcg tcgttgtcat 253021 tatgtcgctc gcgtttttcg gaaaaggctt cggcgcattg ggttgggctg tcgtgtcgga 253081 cacgtctccg aaagaatgtg caggattaag cggcggtttg ttcaacactt tcgggaatat 253141 tgcctcaatt acaacaccga ttattatcgg atacattgtc aatgccactg gatctttcaa 253201 tggcgcgctt gtgtttgtcg gcgctaacgc gattgcggcg atcctcagct atttgctgct 253261 ggtcgggccg atcaaacggg tcgtgttaaa gaaacaagaa caagaccccg atcaatcgtt 253321 gcctgtctaa tatttatgaa agcgctttat aaagggagga aaatgcatga gttcaccgat 253381 acaagagcag gttcaaaaag aaaaaagatc gaatattccc tcaatttctg aaatgaaggt 253441 gattcctgtt gcgggacatg acagcatgct gctgaatcta agcggagcac acagcccgtt 253501 ttttacccgg aatatcgtaa tcttaacaga cagcagcgga aatcagggag tcggcgaggt 253561 gcctggcgga gagcatattc gccgcacact ggagctgtca gagccgcttg ttgtcggaaa 253621 atctatcggt gcgtaccagg cgatattgca aacggtcaga aagcagtttg gcgatcagga 253681 caggggaggg cgaggaaacc agacgtttga tttgcgcacc actgtgcacg ccgtcaccgc 253741 actggaagcg gctttgttgg atttgcttgg aaagtttctt caggaaccgg tcgcggcttt 253801 gctgggcgaa gggaagcagc gtgatgaagt aaaaatgctc ggttacctct tttacatcgg 253861 cgaccgaaat cggacgacct tgccgtatca aagcgatgag cagtcagatt gtgcgtggtt 253921 ccgtctgcgc catgaggaag cgctgacgcc ggaggccatt gtgcgtcttg ccgaatccgc 253981 acaggagcgc tatggctttc aggatttcaa attgaaaggc ggggtgctgc ggggagaaga 254041 ggaaatcgaa gctgttaccg cattatcgaa acgttttcca gaggcaagga tcactcttga 254101 tccgaacggg gcatggtcat tagaggaagc tattgcatta tgcaaaggaa agcaagatgt 254161 gctcgcgtat gcggaagatc catgcgggga tgagaatggc tactccgctc gtgaagtaat 254221 ggctgaattc cgccgcgcga cagggcttcc gactgcgaca aatatgattg cgactgactg 254281 gcgggaaatg ggtcacgcga ttcagctcca cgcggtcgat ataccgctgg ctgatccgca 254341 tttttggacg atgcaagggt cggtgcgggt tgcgcaaatg tgccatgatt ggggtttgac 254401 atggggctcg cactccaaca accactttga tatttccctt gcgatgttta cccatgtggc 254461 agcagcggct ccggggcgga tcacggcgat tgatacccat tggatctggc aggacgggca 254521 gcgattaacg aaacagcctt ttgagatttc ttctggctgt gtcaaggtgc cggataagcc 254581 tggactaggc gtcgatattg atatggaaca agtggaaaaa gcgcatgaga tctatcggaa 254641 aatgaattta ggcgcacgga atgatgcgat cccaatgcag ttcctgatca gcaactggga 254701 atttgaccgg aagcgcccgt gtcttgtgcg ataagtttga ttgtaaatat tgtcatatcc 254761 gctattttgt cttacaattg aacaactgaa gggagagttg ttcgtgtacg aaggtttaga 254821 ggatttgaaa gtcgatacag tcaatcggaa aacattagcc aagcaggtca tcgaacggat 254881 tgtccattta ttatcgagcg gacagttgag ggccggagac aaattgccga cagaaatgga 254941 actgatggac attttgcatg tcagcaggcc ggtgctacgg gaagcactca gttcacttga 255001 aacgctgggc gtcattacga gaaaaacacg agggggcaca tatttcaacg ataaaatcgg 255061 catgcagcca ttttccgtca tgcttgcttt ggccactgat aatcttccgg ctatcattga 255121 agcgcggatg gcgctagaac tcgggctcgt gacaattgcc gcggaaaaaa tcaatgagga 255181 agagcttcag cgtttgcaga agacgatcga cgatattgcc aacagcactg acaatcatta 255241 tggtgaagcg gataaagagt tccatcgaat tattgcgtta agcgccaata accccgtcgt 255301 tgaagggatg attcagtccc tgctgatcac ccatgcgaaa attgacagcc aaattccgta 255361 cagggagaga gatgtaacgg tcgaatatca caaaaaaatc tacgacgccc ttgccaaaag 255421 agatccgtac aaagcacatt accacatgta tgagcatctg aaatttgtcc gtgacaaaat 255481 tctaaaagga atggatgaaa aataatggtg agcaaccgca gttgaaacgt aagagctgcg 255541 gtttttttaa accaatttag aaaacgctta ctaaaatatg aggagtgatt ttcatatggc 255601 gatgaacctc aggaagaacc aagcccccct ttacatcaaa gtgcatgaaa tagataacac 255661 cgcgattatt gtaaatgatg gagggctgcc aaagggcact gttttctcat gcgggctcgt 255721 acttgaagag gatgttcctc aaggccataa ggtggccctc accgatctca atcaagggga 255781 cgagatcgtg cgttacggag aggtgatcgg atttgctgat gagacgatca aacgcgggag 255841 ctggatacgg gaagccctcg tgagaatgcc cgctcctccg gcgttagacg atcttcctct 255901 cgcaaacagg gtgccgcagc cgcggccccc acttgaagga tatacatttg aaggataccg 255961 aaatgcggat ggcagtgcgg ggacaaaaaa tatcctcggc atcacgacaa gtgttcaatg 256021 tgttgttggc gttttggatt atgcagtcaa acgaataaaa gaagagctgc tgccgaaata 256081 cccaaatgtc gatgacgttg tgccgctgca tcatcaatac ggatgcggcg tggcgatcaa 256141 tgcgcccgac gctgtcattc cgatccgcac gattcaaaat cttgcgaagc atccgaactt 256201 cggcggtgaa gtaatggtaa tcggattggg atgtgaaaag ctcctcccgg aaagaattgc 256261 ctccgaaaat gatgatgaca ttctatcgct ccaggatcac cgaggttttg cggcgatgat 256321 ccaatccatt ttggaaatgg cggaggaacg gttaatcagg ctgaacagca gaacccgggt 256381 gtcatgccct gtttcggatc tggttatcgg cctgcaatgc ggcggcagtg atgcgttttc 256441 cggcgtgacg gcgaaccctg ccgtggggta tgcggctgat ttattggttc gcgcaggtgc 256501 aacggttttg ttttctgaag tgacagaggt gcgggatgcc attcatttat taacgccgcg 256561 ggctgtcagt gaagaggtcg gacaatcgct gatcaaagag atgaagtggt atgacagcta 256621 tcttcggcgg ggagacgcag accgtagcgc aaacccgtca ccaggcaata aaaaaggcgg 256681 attatccaat gtggtggaaa aagcgttagg ttcggtagcg aaatcaggca caagccccat 256741 ctccggcgtg ctcggccctg gtgaaagagc aaagcaaaaa ggcctgctgt tcgcggcgac 256801 accggcaagc gattttgtgt gcggcaccct gcagctggct gcgggcatga atttgcaggt 256861 gtttacgaca gggagaggaa caccatatgg cctggctgct gcgccggttc tgaaagtatc 256921 gacgcggcat tccttatcag agcattgggc tgatttaatc gatatcaatg ccggccgaat 256981 cgcgacagga gaggccagta tcgaagacgt aggctgggaa atcttcagga cgattttgga 257041 tgtggcaagc ggccgcaaac aaacgtgggc agaccgttgg ggtcttcata atgatttgtg 257101 cttgtttaat cctgctccag tgacttgatt catgttttta tagcggaaag atggaatatg 257161 ctgtaaaatg aaaatcagcg tataggaaac ggaggggtta cagcatggca ttcattagat 257221 tccgagtgac acgaattcaa tagtgaacaa ctctcgcctg aatgcgagag aatcgggatg 257281 aatccgccta tgtatgagcc cttatatggt tatcaaaaaa gagggtggcg tgcctgccct 257341 tttttgtgcc ttcaagcatc ccttctctct actgcaggcc ggagcatgag aaaggggaaa 257401 tgggatgaca aaccttaacg aaaaacagct tatcactgag attgtcgggc ttgcacgcag 257461 ccaaggtttg acggttcatt ctgagaacgc gcaattgaat gaaaccggaa tggactttca 257521 agttgtattt gccaaggacg acacaggtat gccatgggtg ctgcgaaaac cgcggcgaag 257581 tgatgttgtg gaaagagcat ctgcagaagg cataacgctt gcctttctcc gcgcgaatct 257641 gactgctgat gtgccggatt ggagaattca tacaccggaa ttgatcgctt accccatgtt 257701 aaaaggaacg ccggctgctg gaattgactt ggaacaaaag caatatgtat ggaatatgga 257761 tcatcagccg ccgtcagacg actttgtccg cacacttgcc gacatactgg ctgaattaca 257821 tggcacggat caaatatctg ctgggcaatc cggaatagaa gtgataaggc cagaagattt 257881 caggcaaatg acagcagact ctatggttga tgtgaagaat aagcttggcg tatctacgac 257941 gctttgggaa agatggcaaa agtgggtaga tgatgatgca tactggccgg gtttctcttc 258001 tttgatacac ggcgatctcc acccgccgca tatccttatc gatcaaaatg gacgtgtcac 258061 aggacttctg gattggacag aagcgaaggt tgctgaccca gccaaggatt ttgttcttta 258121 tcaaaccatt ttcggagaaa aagaaactgc ccgtttgctt gaatactatg atcaagcagg 258181 cggccgaata tgggcaaaaa tgcaggaaca catctcagag atgcaggcgg cgtatccggt 258241 ggaaatcgcc aagctagctc tgcaaacaca gcaggaggaa cacatcaata tggcgctgga 258301 agcacttggt gtaacatcgg attaagaatt gacttcgttt catgaaccga gtattataaa 258361 ctctacaaat aatagaacgg attaacaatc gtgaggaaga gcaagtacgc atcagaatgg 258421 aggttcagag agtcggtggc aggtgtgaac cgatcctccc ctgatgccga atgggcttct 258481 gaattgcttt gctgaacgga tagtaggcga tgccgggttt ctctccccgt taccaagaga 258541 ggagtatcga aacataggtt ttctgtactt agagtgaacg gctgtatagc tgttaataaa 258601 ggtggtaccg cgagaccctc gtcctttgca taggacgggg gttttttgtg tttcttaaag 258661 gaggtgacgg ccaatgtacg atggctggtg gtggcatagc agatgagtta gaaaggagga 258721 tatcaaatgg tcattgcaac tgatgatctt gaggtcgcat gtcctaaatg tgaaagagcg 258781 ggagaaatcg aaggaacacc ttgcccggcc tgcagcggaa aaggtgttat tctgactgct 258841 caaggatata cgcttctcga ttttatccaa aagcatttga ataagtaaag gagaaaagct 258901 gagctgagat gagagcagaa gagcagagta agattcgtga ggccgcagca ggtacgattt 258961 ttttgctgat cggaacagtt tgttttgcgt ctaaatcgat ttggataaaa tgggcatacc 259021 aaatgggtgc tgagccagat gccgtgctgc tatacaggca gctgctggct gttccgctgt 259081 tttggctgat ttttttaata taccgtcctc caatgccaga cggtaagaaa aaaggagacc 259141 tatggaaggc ttgtggcgcg ggagtgtttt gtttttttct gtctcccttg cttgatttta 259201 tcgggctgaa ccatgtatcc gcaatggttg aacgtatatt gctgatgagc tatccgttgt 259261 ttgtgtttgg attcaccgcg tgtcgtgacc ggaaaatgtc ctcaattcag gaccttttcg 259321 cagttctggc ggtcatgttt gggcttttct tggcgctggg cggctggaat gctgagcttt 259381 tccaggcgaa tatgattgga gctgtattca ttttgttatc ttcggccgtc tatgctggtt 259441 atcttgtcct ttccgggcat ctcgtccatc aaatcggagg gatccgtctc aatgcatacg 259501 ggatgacagc tgctggagct gccatgatgc tttacacagg gataaaatcg gcggctggca 259561 tgaatacgcc aatggcagca tatccgcttt ctatgtatgg tttgttcgca gtaattgcag 259621 tcgttaccac agtgattcca tttgtgctaa tgcttgaggg cataaaacga atcggggcac 259681 agcgagccgc cgccatttca atggcagggc ctatcctgac gattttctat ggagctttat 259741 ttctcggtga acggctcggg ctcattcaag tcattggatg cggtggcgta ttttttgtca 259801 ttacgggcat ggaatacagg aagctgaaaa caggaaaaaa agaataattt ttataaaaca 259861 cacacgtttt tcaattacaa taagtgtaat tacgtgtgtg ttttttgatt ttgtaaaggt 259921 taggtgagga gatgcagcgc atattgcttg tagaagacga ccactcaatc agtgaaatgg 259981 tggatcatta tttaacaaaa gaaggctttg gaattgtgca tgctttcgac ggagaagagg 260041 gcatccggct gtttcagcag ggttcatacg atttggtcct ccttgatatc atgctcccga 260101 agctgaacgg catggatttt ctgaaaatca tccgggaaaa aagcaatata ccggtcttaa 260161 tgatttcggc aaaagatgga gatgtggaca aggcattggg actgggcttt ggggcggatg 260221 attatatcgc caaaccgttt tcgatgattg agctgacagc ccgagtaaaa gccgcgatac 260281 ggcgggcgac gcaatattcg gcagaggagc cggctgtgaa taaggtgatc cggattcacc 260341 agcttgcgat agatatagac aatgtttccg ttttgaaaaa cggagagccg ctccagctga 260401 cgtcaacaga atggcagctg ctgtgcttat ttgcatcaaa tcctaaaaaa gtgtttacga 260461 aagaacaaat ctaccgttcc gtttggaatg aagagtactt tgatgatcag aacatcatta 260521 acgtacatat gcggcggctc agagaaaaga ttgaggatga cccctcctcc cctcaatata 260581 ttaaaacgtt atggggcatc ggttataaat taggagagtt ttagaatgac agtgctatgg 260641 gtggccgctg tcatcgctct ggcgtgtctg aatgtgattc aattcataat gaaaaagaag 260701 cgggacggga atctggctta cacggctgac cagcttagct acatgctcag ccgggattcg 260761 gcaggacaaa ttttgcttcc tacagacgat catgcgctca aagacttgct tgttaacatc 260821 aatcttatcg ttgagaatcg tcagcagatc agcgcccaat ttgccaaaac agagcaatcc 260881 atgaagcgga tgctgaccaa tatgtcgcac gacctgaaaa cgccgttaac ggtcattctc 260941 ggttatattg aagccattca aagtgacccg aacatgccgg acgaagagcg ggaaagattg 261001 ctggggaagc tccgccagaa aacaaatgaa cttattcaga tgatcaattc cttttttgat 261061 ttagcgaaat tagaatctga agataaagag atcccgatca ccaaagtaca tatgaacgac 261121 atatgcaaac gaaatatcct gcactattat gacgctgttc agtcaaaagg ctttcaagca 261181 gccatcgata tccccgatac gccggtgtat gcgcaggcga atgaagaggc tctggacaga 261241 atcctgcaaa acctattgtc caatgcgatt caatatggcg cggccggcaa gttaatcggg 261301 ctgacgctgt cttatgatga gaggaacatc gccatcaccg tatgggatcg cggaaaaggg 261361 attagtgaaa ccgatcagca gcgggtgttt gagaggctgt acacactgga agaatccaga 261421 aataaagcat ttcaaggaag cggcttgggt ttaaccatca caaaacggct tacagaaaaa 261481 atgggaggca tcatatccgt ccaaagcaag ccgtacgaac ggactgcatt tacgatcaca 261541 ttgaaacgca tgacatatta atcgtaagaa tttcttaagg tttgagaaat aaaaatgaca 261601 gggctcgccg ctacaataga aaacaggaaa agagagggaa ggagaaacaa agttgactta 261661 tatcgtacaa acaaacgggc tgaccaaaac atatcagggc aaagaggtcg tatccaatgt 261721 cagcatgcat attaaaaaag gtgaaatcta tggctttctc ggcccgaacg gcgcggggaa 261781 aacaaccatt atgaaaatgc tgacgagcct tgtcaaaccg acaagcggtg aaatcatcat 261841 ccttgggaac aagttcaccc acacgtcata tgaggtgctg gggaacatcg gcagcatgat 261901 tgaatatccg attttttatg aaaacctgac agctgaagaa aatttagatc tgcattgtga 261961 atatatggga taccacaata aaaaagccat acaagaagtg ctggatatgg tgaatttaaa 262021 acaaatcgac aaaaaacccg tcaaaacctt ttccctcggg atgaagcagc gccttggaat 262081 tgcgcgtgcc atcctcacga agccggacct gcttattctg gatgagccgg tgaatggtct 262141 tgaccctctc ggcattaaaa agatcaggca attgtttcaa gtgctgagca aagagtacgg 262201 gatgacgctg ctgatctcaa gccacctgct gggtgaaatc gaacaaatcg cggacacaat 262261 cggcgtcatt cgggacggca ggctgcttga agaggtatca atggaggatg tcaggggcca 262321 gaacactgaa tacatcgagc ttgtcacgcc gaatcagaca agggcctgct ttgtgctgga 262381 gaaagagctg caattaacca actttaaaat attaaatgag aaaacgattc gaatttacga 262441 ggctgaagcc tctcaggctg ccatatccaa agcattgatt ttaaatgatg tagacattga 262501 atcaatgaac aaaaagtata cgtcgctgga ggattatttt atcaaattga tcaacggcaa 262561 tagcatcagt gcgtaaagga ggagagacac gttgatgaat ttgatcagaa tcgaattaag 262621 aaaaatgaaa atgggctggt atatcagagg tgccctcatt gccaacgtga tcattatggg 262681 ttttatgtgg ctgatcagtt attccgaaaa agccgatggc ggggtttcgt tccaaagtac 262741 ggatgaagca ttcctcatca tcggcacctt cgtcagagcg gtatttatcg tatttggcgc 262801 tgtgctgatc gtaaaattgg tgatttcgga atataaaaac aaaaccattc ttgtgatgtt 262861 cacgtacccg atcagccgta aaaagctgct caccgctaag ctcatgatcg cgggcggact 262921 gacgtttatc acgattttac tttcaaatat actcatagcc gccggtttct tttggctgaa 262981 ctcgatctgc catttcatac cgggagagct tacttccgag atcatttctc aacaggcggt 263041 caaaatggcg gttttcgctt ttggcgccgc tggaaccagt ttagttccca tcttttttgg 263101 gatgcgtaga cactcggttc cggcgaccat catttcatct gtagtaattg tgatgctcat 263161 cagctcaaca agtccgggct tctcgatttc atctgttgtg tatatcccgt tatcgttagc 263221 ggcattcggt ttgttctttt cctacatggc gatcaggaat gcggacaagc aggatgcgta 263281 aacaaaggcg cccaatatgt ataaaaggcc gatgctgtca gcaccggcct ttccattatg 263341 agtctgttct tgtttcaaga taatgcttct tgccaatctc tttgctcatc atatagaaat 263401 ggaagcaata ttcaccgatt gccatgacga tcgcgccgaa taaagccgcc aatgcaactt 263461 caccgccagt catccccata gaaagcggca tgcccatcag ccagatcacg agaaaggcca 263521 aaccaaaatc agccaaagtt gcaatcatat tattccattt cggcaataca taaagatcgc 263581 ccagcaaata agaaataacc cctaacacaa tcgtcattag cagcgtatca ccaaacgtga 263641 aaccaaagcc cagaccaagc accagataca acacaataat cgtcataata cctttaatag 263701 cgagcgcttt cacatgtgtc attacaattc ctccttttgt catttgattt gttatgtata 263761 attcctcaaa tgtaaaaagt taaaccttat ttcttttcgg aggcgggtgc aaatctgctg 263821 gggagaggtc aatgatgtga atccaggaat tgaggctgcg gcgcttcgac agcggaaacg 263881 tgaagcttgt actgcaccgg acgctgcttt gatgcccaac agcccattat gtttgctgtt 263941 tttagatgaa taaatttaaa aacttctcct gtccctccgt catcacttct gaagtaatga 264001 aatatgatga aaagagatca aggggaggtg acgtgatggc ggtcgtgaga gcaacgagtg 264061 cggatgtcga tttgatggca aggctgctca gagcggaagc ggaaggcgaa ggcaagcagg 264121 ggatgctgct tgtcggcaac gttggaatta atcggctgcg ggcgaattgc tcagatttta 264181 aaggcctccg caccatcagg cagatgattt atcagccaca cgcgtttgag gctgtgactc 264241 atggatattt ttatcaaagg gcgcgagata gcgagcgtgc ccttgcacgc cggtcgatta 264301 atggtgaaag gcgctggcct gcaaaattta gtttatggta cttcaggccg cagggggact 264361 gtccagccca gtggtataac cagccgtttg tggccagatt taagtcacac tgcttttatc 264421 agccgacggc ggagacgtgt gaaaatgtat ataacacatt ttagagacag gacaccgttc 264481 aaattgaacg gtgtttttct ttgaaaagat gcaatgcaaa atattcctgt gagataatca 264541 aagaaaaaag agctgacgga gatgacagaa tggcaacaat tgacctgcaa aagaaaagtg 264601 taaagatcgt actggagaaa aagcagttaa cgaaggtgac ggctcgtgtt ggactggttc 264661 ttgatattac gggatcgatg agaccgctct acaaaaacgg gacggttcaa aatgtggtgg 264721 agcggatttt ggcagtggct gatcagtttg atgataacgg tttgctggat gtatgggtgt 264781 atgataatga attttcccga ttaaagccag tttcagaaaa ggatttttcg ggctatgtcg 264841 atcgtgaaat tttaaataat gaccgcttgc ataaattcgg cagaaatgat gagccgccag 264901 tcatgaagga cgtgctgcgc aaatatgtta cggaggaacc gagctcgtat cctgctttca 264961 ttgtttttat caatgacggg ggctgtaaaa agtcaatcaa accgataatt gaagcttctt 265021 ctgataaacc ggtgttctgg cagtttgtcg gcatcggaaa cggaaacttt gattttctca 265081 ataaactgga tacgttagaa gggcgtgtca ttgataacac gaacttcctg catatcgaag 265141 agattgaccg catttctgat gatgagcttt atgatgctct gcttgctgaa tttccatttt 265201 ggctgaaaga agcgaaggaa aaagggattg taagagaaca agagcctcct gctgaaaagc 265261 cgaaaaagaa gggctttttc agcagattgt tttcgaaata actgataaag agcactgagt 265321 cattctgcga aatggctcgg tgtttttgtt tttttaagat catgtgaaga aaaataggcc 265381 gaatgggcgg cttgcaaacg acaggatatg cagaaaacgc gtcattcagc cagctttcgg 265441 catgtttcag cagcaggctt gtgagggaag acctgttttt aatgttcagc gcttacaatc 265501 agttcacact tcttcacagt cgtttaacaa tgatttccta taatggagac gatcaatgag 265561 gagagagggg atcttgaatg gcatacgaca gtcgttttga tgaatgggta cagaaactga 265621 aagaggaaag ctttcaaaac aatacgtttg accgccgcaa atttattcaa ggagcgggga 265681 agattgcagg actttctctt ggattaacga ttgcccagtc ggttggggcc tttgaagtaa 265741 atgctgcgcc taacttctca agctatccgt ttacattagg ggtagcgtca ggtgatccgc 265801 tttctgacag tgtcgtgctt tggacacgtc tggcaccaga tccgctgaat ggcgggggaa 265861 tgccgaagca agcagtgcct gtcaaatggg aggtcgcaaa ggatgagcat ttccgcaaaa 265921 tcgtaagaaa aggcactgaa atggctaaac caagtcttgc ccattccgtt catgtggaag 265981 cggacgggct tgagccaaac aaagtgtact attaccgttt caaaaccggc catgaactaa 266041 gccctgtcgg aaaaacaaaa acactgcctg cccctggcgc caatgtgccg caaatgacct 266101 ttgcatttgc ttcctgccag caatatgagc acggatatta tacggcctac aagcatatgg 266161 caaaggaaaa gcttgatctt gtcttccatc tcggtgatta catatatgaa tacggcccaa 266221 atgaatatgt atcaaaaaca ggcaatgtcc gcacgcacaa cagcgcggaa atcattacgc 266281 tgcaagacta tcggaaccgt cacgctcaat accgttctga cgccaatctt aaagctgcac 266341 atgcggcatt cccttgggtt gtaacttggg atgaccatga agttgaaaac aactatgcca 266401 ataaaatacc tgaaaaagga cagtcggttg aagcattcgt gctccgccgc gcggcagcat 266461 accaggcata ctatgaacat atgccgctcc gcatttcctc tttgccgaat ggcccagata 266521 tgcagctgta ccggcacttt acgtacggaa acctggcgtc cttcaatgtg cttgataccc 266581 gccagtacag ggacgaccaa gccaataacg acggcaataa gccgccttct gatgaatcgc 266641 gcaatccgaa tcggactctg cttggaaaag aacaggagca gtggctcttc aacaatttgg 266701 gcagctcgac agcccactgg aatgtgctgg cgcagcagat tttctttgcc aagtggaatt 266761 tcgggacaag cgcaagcccg atctacagca tggattcgtg ggacggctac ccggctcagc 266821 gcgaacgggt tatcaatttc attaaaagca aaaatctgaa taatgttgtc gtactgacag 266881 gtgatgtaca cgcaagctgg gcatcgaatt tgcatgtcga tttcgagaag acaagttcaa 266941 aaatattcgg agccgaattt gttggaacct cgatcacttc cggagggaac ggagcggata 267001 agcgagcgga tacggaccaa attttaaaag aaaatccgca catccagttc tttaacgact 267061 atcgcggata tgtccgctgt acagtgacgc ctcaccagtg gaaagccgat tatcgggtga 267121 tgccatttgt gaccgagccg ggcgcagcca tttccacgcg ggcttcattc gtttaccaga 267181 aagaccaaac cgggttgaga aaggtatcat ccacaacaat ccaaggcggg gtgaagcaat 267241 ccgatgaggt cgaagaggat cgtttctttt cgcacaacaa agcccacgaa aaacaaatga 267301 ttaagaagcg tgcaaaaatc acgaattaag gagtggaaat tatgttttca aacattggaa 267361 taccgggctt gattctcatc ttcgtcatcg ccctcattat ttttggccct tccaagctgc 267421 cggaaatcgg gcgtgccgcc ggacggacac tgctggaatt taaaagcgcc acaaaatcac 267481 ttgtgtctgg tgatgaaaaa gaagagaaat cagctgagct gacagcggta aagcaggaca 267541 aaaacgcggg ctgaatgctg atgaggcaga caccgggtct gcctcttttt ttatgaaagg 267601 gagggctttt ttgaatggat aaaaaagaaa cccatctgat cgggcattta gaagagcttc 267661 gccgccggat tatcgtcacc cttgcggcat tttttctatt tctcatcacg gcttttttgt 267721 tcgtacagga catttatgac tggctgatca gggatttgga tggaaagctg gctgtgctag 267781 gaccgagtga aatcctctgg gtgtatatga tgctttccgg catttgtgcc attgcggctt 267841 ctatccctgt tgccgcgtac cagctgtggc gtttcgttgc accggcgctg actaaaacgg 267901 agcgcaaggt gacgctcatg tacataccag gtttatttgc gttgtttttg gcgggcatct 267961 ccttcggata ctttgtcttg tttccgatcg tgctcagctt tttgactcat ttatcctccg 268021 gccactttga aacgatgttt acggctgacc gctactttag gtttatggtg aatttgagcc 268081 tgccgttcgg cttcttgttt gagatgccct tggtggtgat gtttttaaca aggctgggca 268141 tcttaaatcc ttacagactg gccaaagcga gaaagctttc ctattttctg ctgattgtcg 268201 tgtccatatt gattacaccg cctgatttta tttctgattt tctcgtgatg atcccgcttc 268261 ttgtcctgtt tgaagtgagt gtcaccctat cggcgtttgt ctacaaaaag aggatgaggg 268321 aagaaacagc ggcggccgct tagtgcagcg taccacccgg tgacttcaca tcctcatcat 268381 attgtgcggc cgtaacagcg gcgattctca atgcccggac aatcgtgtcc aggctgaggc 268441 tcggcgctgt tttgtcgatt gtttgctgcg gaatgtaagg aatatgaata aaaccgccgc 268501 gaatgtgtgg ggatgtccgg ctaatgtgat ccattaaccc gtagaacaaa tagttgcata 268561 caaaggtccc cgctgtgtag gaaaccgcag ctggaatgcc gtgttccttc atcttagcag 268621 tcattcgttt cacgggaagc cttgtccagt aagcggcggg cccatctgga gaaatctctt 268681 catcaatcgg ctgatgtcct tcgttatcgg ggattcgcgc atctgcaagg ttgattgcca 268741 ctcgttccgg tgtaatctgc atccgtcctc ctgcttggcc gacacaaatt acgatatctg 268801 gctgatgttt ttgaatggct tggcgcagag tgtccagagc ggatctaaag acggttggaa 268861 tttgttccgc tgtaataatg gcttcttctg tctcgaagcc attaagccgt ttcgccgctt 268921 cccatgatgg attgacggtt tctttgtcaa aagggtcaaa gcctgtgatc agcacttttt 268981 ttctcattct cccatctcct ttttctttta ttctattgtt tatttatggg tttttcatca 269041 aaataatgta aaggagtgaa tcataatgga gcatttgccg gagcagtatc gccagttatt 269101 cccaaccttg cagacgcata cgatgcttgc cagctgttct cagagcgcat tggcagagcc 269161 tgtatcaagg gcgatccagg attattatga tagcctgctg tataaaggga cgaactggaa 269221 agaagcgatt gaaaaaacag agtttgcgag aaacgagttt gcaaagctga tcggggctga 269281 accggatgaa gtggcgattg tgccgtcagt ttctgatgca ctggtttctg tagcatcgtc 269341 cttaactgca tttggaaaga agcacgttgt atatacagat atggattttc cggcggtgcc 269401 tcatgtttgg caggcacact ccgattatac cgtatccgtc attccatcaa tagacggcgt 269461 gctgccgctt gaacaatatg aaacgcatat ttcggatgaa acagtactga cgtgtgttcc 269521 tcacgttcat tatcgtgacg gctatgttca ggatataaaa gcgattgccg agatttctca 269581 gagaaagggc tctttattgt ttgtagatgc ttatcaatca gccgggcata ttcccattga 269641 tgtgaaggaa tggggcgtag atatgctggc agcaggcacc cggaagtatt tgctcggcat 269701 accgggtgtg gcgtttcttt atgtgagaaa ggagctggct gacgcactga agccgaaagc 269761 atcagcttgg ttcggaagag agagcggatt tgatggggct tatgcaaaag tcgcgcgccg 269821 ttttcaaacg ggcaccccag cttttatcag cgtatacgca gctgcagcgg ctttatcgct 269881 gctgaatcat attggggttt ctcatatcag ggatcatgtg aaaacgatct gtgccgatgc 269941 agttcaatat gccgctgaaa aaggcctgca gctggcggcg gcacaaggtg ggattcagcc 270001 gggcatggtt gcgatccggg atgagcgggc atcggaaacg gcggggttgc tgaagaagaa 270061 aaaagtgatt tgcgcgccgc gggaaaatgt tatccgtctc gctccccatt tttataatac 270121 gaaggaggaa atgcggcacg cgattgatga aatcgcggcg aaaacgatcc acaagtaaac 270181 atgaaaaagc ccctgaacac tagtcagggg cttttcatat taatgatcta ctttaacgcg 270241 tttcataaag aaagcgccaa ttaaaccgat aatggcaaca atcattgcaa acacaaatgc 270301 gtgctgtacg cctgctgtca aagcttgcgg gatgactgcc ggatcggcag ggtttttaac 270361 tgtactcata taatcatgct ggcctgcagc cataatgctg accgcaaccg ctgttccgat 270421 agcgccggcc atttgctgca gcgtgttcat aatggcggtg ccgtctggat aaaattcacg 270481 cggcagttgg tttaaaccgt ttgtctgtgc aggcatcatg atcatagaaa tcccgatcat 270541 caagcaggtg tgcaggatga taatcagcac agctgttgaa gtggtcgtga catttgagaa 270601 gaaccatagt acaacggtga caatcacaaa tcccggaatg acaagccatt tcggcccgta 270661 tttatcgaac aagcggcctg taacagggga cataaatcca tttaaaatac cgcccggcaa 270721 gagaacaaga ccagatgcaa atgcagtgag gactaagccg ccttgcagat acatcggcag 270781 aagcagcata gatgacagaa tgaccatcat acaaatgaac accatgatca cacccaaaat 270841 aaacatcggg tatttgaacg cacggaggtt catcataggc tgcttcattg tcagctggcg 270901 gattgaaaat aagataaggc cgacaacgcc gacaatcagc gacacgataa cagtcgggct 270961 ggaccatccc ccggagcctt cacccgcgtt gctgaatccg aatacaatgc cgccgaagcc 271021 aatcgtcgac aggatgatag acaatacatc gattttcggc tttgtcgttt cagatacatt 271081 ttgcatatat gcgataccga aaacaagcgc cagcacaagg aatggaagag agatccagaa 271141 aatccagtgc cagttgagat gctccagaac caatcctgag aaagttgggc cgatggcggg 271201 cgcgaacata atgacaagcc cgatcgttcc cattgcggca ccccgtttat gaggcgggaa 271261 aatcaccaag attgtgttaa acatcagcgg cagtaaaaga ccggttccaa gtgcctgaac 271321 gatccttgcc gctaataaaa acgagaagct cggcgcaagc gccgcaatga atgtacctaa 271381 aattgaaaag ataagtgaca cggtaaaaag ctgtcttgtt gtgaaccact gcaacagcag 271441 tcctgaaaca ggaacaagga taccgagtac aagcaggtag cccgtcgtta accattggac 271501 ggttgccgct gtaatgttca attccttcat aaggtcggtt aacgcaatat tcagcgctgt 271561 ttcactgaac atgccgataa aaccggccaa cagcaaggaa atcataatcg gcatcacttt 271621 gtattgctga gatgctttag ctgttgtttc caaaatcatt tcccctctct atcaactgca 271681 tgtagtatgt cgtttttttt atctcttcag caggtcagga atgcagctgg agatatgaag 271741 gagcggcgta ctgttttttg ccgtcaaaga taaaaggatg ccgccttcaa tcatcgcgtt 271801 aaccacagtg ctggcttctt ttgcacggct ctcgctgcag ccagtctgcc gcagtttttc 271861 ctcatacaca gaggcccatt ctttgtaggc ttcatgacag gcttcgcgca acggttcgct 271921 tttcaatgac gtctcagccg ctagcaagcc cacaggcaag ccttcaatgt cttccgtaca 271981 tgaaaactgg caggagagct ccttcaaaaa ggcttgaatg ccttccgctg gatcggtgca 272041 ggcttccatg cagtccgcga ttttctgacg gatatactcc ttcatctcat tcacggcttc 272101 gatcgcaagc tgttctttac ccccgggaaa gtggtagtaa agagagcctt taggcgcgcc 272161 gctttccttt ataatctggt tcagccccgt gccgtaatac ccttgcagct gaaaaagccg 272221 ggtagctgcc gaaaggattt tctcacggga atctccataa ctcataacat tcccacctta 272281 ctgaattgca atcaaaaata tagtgactgg tctattatct tgattcaatc atcaattgtc 272341 aagaaaaatt cattgtatga aaagacaaaa aaagaaggat atgacaacaa aaaatactga 272401 gagaaaagct gactgatctt ttgactgaat agataaaatg tacaatgatt aatcatcata 272461 tggatgtaag gagagaaata gatgaaaaaa caacgaatgc tcgtactttt taccgcacta 272521 ttgtttgttt ttaccggatg ttcacattct cctgaaacaa aagaatcccc gaaagaaaaa 272581 gctcagacac aaaaagtctc ttcggcttct gcctctgaaa aaaaggatct gccaaacatt 272641 agaattttag cgacaggagg cacgatagct ggtgccgatc aatcgaaaac ctcaacaact 272701 gaatataaag caggtgttgt cggcgttgaa tcactgatcg aggcagttcc agaaatgaag 272761 gacattgcaa acgtcagcgg cgagcagatt gttaacgtcg gcagcacaaa tattgataat 272821 aaaatattgc tgaagctggc gaaacgcatc aaccacttgc tcgcttcaga tgatgtagac 272881 ggaatcgtcg tgactcatgg aacagataca ttggaggaaa ccgcttattt tttgaatctt 272941 accgtgaaaa gtgataaacc ggttgttatt gtcggttcga tgagaccttc cacagccatc 273001 agcgctgatg ggccttctaa cctgtacaat gcagtgaaag tggcaggtgc ccctgaggca 273061 aaagggaaag ggacgcttgt tgttcttaac gaccggattg cctcagcccg atatgtcacc 273121 aaaacaaaca caactacaac agatacattt aaatcagaag aaatgggctt cgtcggaaca 273181 attgcagatg atatctattt taataatgag attacccgta agcatacgaa ggacacggat 273241 ttctcggttt ctaatcttga tgagctgccg caggttgaca ttatctatgg ataccaaaat 273301 gacggaagct acctgtttga cgctgctgta aaagccggag caaaggggat tgtatttgcc 273361 ggttctggga acgggtcttt atctgatgca gccgaaaaag gggcggacag cgcagtcaaa 273421 aaaggcgtta cagtggtgcg ctctacccgc acgggaaatg gtgtcgtcac accaaaccaa 273481 gactatgcgg aaaaggactt gctggcatcg aactctttaa acccccaaaa agcacggatg 273541 ttgctgatgc ttgcgcttac caaaacaaat gatcctcaaa aaatccaagc ttatttcaat 273601 gagtattgaa gaaaagaagg cgaataagcc ttcttttttt tggcttttta ggaccaataa 273661 tgacctctga atcttaaaat ttctttaaaa ataagccaaa attacccttt acttaattaa 273721 tttggtaacg taatataatt ggagaatttg ttacaaaaaa aggaggatat tatgaaattt 273781 gtaaaaagaa ggatcattgc acttgtaaca attttgatgc tgtctgttac atcgctgttt 273841 gcgttgcagc cgtcagcaaa agccgctgaa cacaatccag tcgttatggt tcacggtatt 273901 ggaggggcat cattcaattt tgcgggaatt aagagctatc tcgtatctca gggctggtcg 273961 cgggacaagc tgtatgcagt tgatttttgg gacaagacag gcacaaatta taacaatgga 274021 ccggtattat cacgatttgt gcaaaaggtt ttagatgaaa cgggtgcgaa aaaagtggat 274081 attgtcgctc acagcatggg gggcgcgaac acactttact acataaaaaa tctggacggc 274141 ggaaataaag ttgcaaacgt cgtgacgctt ggcggcgcga accgtttgac gacaggcaag 274201 gcgcttccgg gaacagatcc aaatcaaaag attttataca catccattta cagcagtgcc 274261 gatatgattg tcatgaatta cttatcaaga ttagatggtg ctagaaacgt tcaaatccat 274321 ggcgttggac acatcggcct tctgtacagc agccaagtca acagcctgat taaagaaggg 274381 ctgaacggcg ggggccagaa tacgaattaa tgaaaaacaa aaccttgaag aatgctattc 274441 ttcaaggtta ttctgctttc agcacaatgg ttttcgcagc catatcatga acggtttgtt 274501 ttttcttcgt aaatgcggca gtcaaataga tcaggcggga gaacacatgc acccacgcta 274561 tcaggtaacg gacaatggct tgcgggaagg atattttttt atatgtttcg tccctcacga 274621 tttgcagccc gatgattttt ttgcctagtg tgcccttcca atttgtcagc ggcatcagca 274681 aagggtacac aatcagcatc aatatggcga caataatgac accggcggac ccatcgccaa 274741 acgtaaatcc ggctgccaaa atcactgctg cggcaatgat tacatcaagt aaaagagcgc 274801 aggcgcgcag catgaaacca gctagttcca atagaaacac tccttaaaat gttaaataaa 274861 cacctaatga ttgtaaaaaa gaagggccta aagtgggaat aggtgataag ccttaaatca 274921 caaaagttgg tgaaaatgtc ataggtaaat tggcataatc agccagctta tcacattacc 274981 aaattctttt ttagcccgaa accaagccct cagaagttat ttttgttaaa atagaaaagt 275041 tacaacagaa ttcggagggt ttattgtggg aaaagtgaaa cgaaatgccc cttgcccatg 275101 cggcagcggc aagaaatata aaaaatgctg cggaagtaaa gttgtcgact tcccggcgga 275161 actagcggca aaagaagcga aacaaattca ggaagactta gtggagtatg ccttcacagt 275221 acatagagaa agcatttcag gctttatcaa ccagcatgat tttctttctg ctatggacag 275281 acagacgaaa gacatcagcg tatttaactt aggaatctgg ggaatcttct tccacccgct 275341 tgctggtgag aagacaatct tcgaagagta ccttcagaaa aaaggcgatt cgatcactcg 275401 tccgaaaacg cgtgagatcg tagaatcatg gcagagcatg acgcctgctt tattgctgct 275461 gaaggacctg aaggaaggca tcattcactt tgaagatgtc attacggcaa aacaattcga 275521 agtggaaatg gacgccagca atcaagacct tcctccagtg ggaagcctga ttcttggata 275581 cccaatccac gaagcggaaa aagcagaatt cttcatgcag ttcacgatct tcccggtgaa 275641 gagaacagaa gcgctgatca gcaaggtgaa gaaatatgcg gatgccgctg tgaaggacgg 275701 caaaacgccg gaggacttca tgaagcagga attcaacaac gttctgttcg cgttgttagc 275761 tgagaaagat gaagagccac aagcagagaa agcggaagta agcactgttg agtgggcaaa 275821 cgacttggag aaagaaaccg ctgcggctat tgaagaaggc atgagcgggg aagagtatcc 275881 gactgaattg atcccagctg ttattgacat ctggaaaaca ttctgcgaga aaaaatcacc 275941 tgtcatcaga aagccggaag cttttgcggc ggcagttgaa tattatgtaa acgcaatttc 276001 tcttaacggc gcgtccgttt cccaggctaa actggcgaaa aaatacggcg ttagcgcatc 276061 aacgatttcc agccgttaca aagaaattga aagcacgctg caagatgaag cagatcgttt 276121 tgcacaagcg ttatcctcat aatggaaaaa accttgaaaa gccaggcttt tcaaggtttt 276181 tttatttctg aaacggaatt ttgatttcta accggaagat ggggtggcgg taggtaaaat 276241 ccagcctgcc aaaagcgccc ttcaccagtt tttgaatgat atatgtgccc atgccttcat 276301 gagcgccgtt tttcgttgag cggccaaacg attgataaat tgtatcgagc acttttgggt 276361 ccatcccggg agtgctgttt tcacaagtca gtacataaag cccgctgcgc agtgaagtct 276421 ccagtttaat ctctgctttt tctcgggcct ccgccgcgct gtcgagcgca ttttctaata 276481 tgttgccgac caagctgacc tgatcagcag gcgaaaacgg aagggaagaa agcggtgtat 276541 gcatatgcag cgaaacactc acattcgagg cgcgggcttt ttctaaaaaa tcataaagca 276601 cccctgcaac gtacgcgttc tctcctttca aaaaacggtc atattggctg tattgatccg 276661 cccagttttg aatatatgct tgtgtatctg ccttgggctg agctgatttg attgcagtga 276721 tatgtttcat tgtgtcatga ttccggcttc tgacatcaat cagcatttga ttggcgtgct 276781 gttcagcttg agtcagctta tcaatttgat cagaaagcct tgcctgcaaa gcagactgtc 276841 cgatacggag cccttcacac cctgcaaata tcgcgattac acataatacc ggcatgatgt 276901 ctgtgccaat caacaccact cccaccgaca tcacttgaat caccgcaatc cacgcacaaa 276961 gccctgagga acagtgtttc cacacccgct tcgtattcca aatgtacaat cctgcagcag 277021 ctgcgcctaa agcagcggcg agccaagagg cggctgtgct gtgtgaaaaa gcagcagctc 277081 cctgataaca tatgaaacta aataaaatca gataaagaca ttgaaaaagg gtaatcacgt 277141 actaaactcc tcaaaaatag tagttttgaa aataatcaag ctgctgctta gtgatcatcg 277201 cttttttaga cgttccctca aaggaaactg tgaatgaatg cttggtataa gcggaaaaat 277261 gctttatgta atgaatgttg ataataaagg aacgatgcga acgaagaaaa tctttttcgg 277321 gcaggtcgcc tttaatatca tttaatgttt gatacgtttg cacctcttcg gcggttgtca 277381 caatcgtcgt cgaacgtccc gtccgttctg cgaaaataat atccttcttt tgcaggacgt 277441 gcatttcaga cttttgcttt atcaatatac gcccattcaa actcgtttcc gttttctttt 277501 tcaagtaccg gtcgaaggaa gcggccagac ggtcggcata gtacggcttc ataatataat 277561 catggacgtt caggtcaaag gcgtgaaccg cataaccgcc gtggccggta acaaaaatca 277621 catccacatc aagtgaatgg gatttgatca aatcagcaag ctcgtagcca gacatatggg 277681 gcatctcgat atcggcaagc agcagatcaa tgtctccgtt ctttacccgc ctgtaggctt 277741 ccttcgctga atcggtggaa aagacaattt cgacgtcctg cattctggac acgatcgctt 277801 ctaacttctc taaatctact cgataatcat ctacaagtcc gacttttacc attatcattc 277861 ccctagttac atagaatcat ctttattcta tcccatttca cgacataaaa agaactcttc 277921 gcgacaactt tatccaacta atccagcttt tcgtatatag tcattactag aaataaagat 277981 aagggagatt gtgacatgat tacactgacc gattgcagcc gcaggtttca ggataagaaa 278041 aaagtagtca aagcggtgcg agatgtaagc ttaacaattg aaaaaggaga agtcgtcggc 278101 attctcggag aaaacggtgc cggcaaaacg acgatgctga gaatgattgc ttccttgctt 278161 gaaccatcac agggtgtaat cacagtagac ggctttgaca cggtcaagca gccggctgag 278221 gtcaaacaaa gaatcggtgt cttattcgga ggagaaaccg ggctttacga caggatgacc 278281 gctaaagaaa atctccaata cttcggcagg ctgtatgggc tgaaccgcca cgagatcaaa 278341 gcaagaatag aagatttatc gaaacggttc ggcatgcgcg attatatgaa ccggagagtg 278401 ggcgggtttt cgaaaggcat gaggcagaaa gtcgccattg ccagagcgct gattcacgat 278461 ccggacatca ttttatttga tgagccgaca actgggcttg atattacgtc aagcaacatc 278521 ttccgcgaat ttatacagca gctgaaaaga gaacaaaaaa cgattctttt ctccagccac 278581 attatggagg aagtgcaggc gctctgtgac agtgtcatca tgattcacag cggagaggtg 278641 atttaccgag gggcgcttga atcactatac gagagcgagc gcagtgagga tttgaattac 278701 atctttatgt ctaagcttgt cagggggatt tcttaaatgc tgagccatat ttataaaaaa 278761 gaaatgatcg acgctttacg cgacagaaaa acgatattac tcacaatctt agtgccgatg 278821 attatgatgc ttggacttgt ctttttttat gaaagcatgc tgtccgacaa aggggagcag 278881 tacacgctgg ctgtcggcca ttcgcttccg cccgcactgg aaagcaagct taatgagatt 278941 gacgaaatca gcgtaaaaac atttgcaaag cctgaagagg cagttgatga aggaaaagca 279001 gatgcctatc tgaacgtccc gaaagagttc gactcatatg tcaacagcat gacacctttt 279061 aaggttgatg tttacggcaa ttcaatcgat caagggtcgt caaatgccat gcagcttgtg 279121 cagtctgcct tagatcagta caaaaatgaa attgtgcagc aacgtttaac aaataagcat 279181 attgatcaat cggtgatcca gccgtttaca attcagcaaa aggaagcgga tgaggagaaa 279241 gggacttccg ctattatgct ttccgccatt ctgcccatgc tgattctgac ttccattgtt 279301 tccggcgcaa tgccgatcgc tcttgatatc atggccggtg aaaaggaccg aaagtcaatc 279361 gaggcgctgc tattaacgcc agtcagcaga aacaaagtgc tggtcggcaa gtggcttgcg 279421 gtttccactt ttggcgtggc ttcaggtgta tttgctttgg tgtttttgat tttgtccacc 279481 gtgttattta ccgaaaattt aaaaacggcc ttccagctgg gagatcatat gtggagtgta 279541 atcggcgctt cagccttaat cattgtgctc tctgcattgc tgatatctgc gatggagctt 279601 ttcatcagca tcatgtccag ctcggtaaaa gaagcgcaaa gttatatgtc tctcgtcgtc 279661 tttctgcctg tgttcccgat gtttttcatc ttcagcaagg caccgaacca atttgactta 279721 tcatactttc tcatcccgtt tctgaacctg catgcgttat ttaaacagct tttattcggg 279781 atggttgacc cggctaccat tttgtctacg tcaggaacca tcgccgtgct catcgccatc 279841 ttctttttac tagccagagc ctgcttcctg aaagacaaat gggttcttcc aaaataaact 279901 tgcgaaagga gaaatacact ttctcctttt tgtatatcct gaaaaaagaa ggaaaataga 279961 aaaaggatat ctaatacaaa aagtgaccct gcactatttt tcatcaaaat tggtttcaaa 280021 ggagaaggaa caatggatca aacacgtaca ctcggcaaaa cgaagctgaa ggtgaagcgg 280081 atcggattcg gcgcgaatgc ggtcggcggg cataatctat ttccaaatct aaatgatgaa 280141 acagggaagg atttagtgcg cacggcattg gatggcggcg tcaattttat cgataccgcc 280201 tttatatatg gattggggcg atctgaagaa ttaatcggcg aagtcgtaca ggaacgcggc 280261 gtgcggaatg agctcatcat cgccaccaaa ggagctcata aagaagtgga cggcagcatt 280321 gaattagaca atagccggga gtttcttcgc agcgaggtgg agaagagcct gaagcggctg 280381 aaaacagatt acattgattt gtattatgtt cactttccgg atggaaaaac acctctcgct 280441 gaagtggcgg gcactttgaa agagctgaag gatgagggga aaatcaaagc gatcggcgct 280501 tcgaacctcg attatcagca attgcaggat tttaatgctg acggctattt ggaggtcttc 280561 caggccgaat attctctcat acagcgtgat gccgagaaag agcttcttcc atactgtgaa 280621 aaacaaggca tctcctttat tccttacttt ccgcttgcgt ccggactgct gacaggaaaa 280681 ttcacgcaag acacagtctt tgatgatttc agaaaggata aacctcaatt tcagggtgaa 280741 acgtttatcc acaatctcaa aaaagtagat aagctgaaag cagtagcgga ggaaaaacaa 280801 gcggatacgg cacatgtcgc cttggcgtgg ctgttaacga gaccggcgat tgatgccatt 280861 attccaggag ctaaacgacc ggagcaatta caggataacc tgaaaacctt gaacattgaa 280921 ctgaccgaag atgaagtgaa tttcatcagc gacattttca aataaaaaag gaaatagccg 280981 tcatggctat ttccttttgg tgttttattc tttgatgaat gcttcgacta attctgctgc 281041 tctgtaatca tccatatcaa gctgccattg gtcgatgtca tttttcttca ttttcacttc 281101 aactgttttt tcagatgaag caggtccaag ctttttgaat tcctcaggat agacttgaag 281161 cgcgtatttc actgcctctt catagctggc actagagttt ttactgtagt agtctttcac 281221 tttgtcttcg atgcggtctg aaagagaaga tgcatctaca ggtttaactg tggcttcaac 281281 aattgcttcg tctttagaga ttgaagtcgt ttttgcttga atggaagagt ttttgcttaa 281341 tccctcttta atgccgttca cgatattatc aagcgctttg ctgtccgcat atgtgctgga 281401 aaggccggaa gctgagagat aaccgtcttt ggctgattca ttaaaatcat ttacaatttc 281461 atttttgtta gcgccggtga ttttttcgaa atcggcgtta tctttgccga aaagaaggac 281521 atcaacataa gctgataacg cttttgcaga atcttggagc ttatctgccg tcgccaggat 281581 ttttttgtct tttccgtcaa ttttaaaagt aactgatttt ggctttttat caccgtaaga 281641 ttccggcgta tagttaagct cgtattgctt gcctttatct acaacgaaga aaagatttcc 281701 ttcaacggat ttgtcagcgt taatcgtgct gccctgaagc ttttcgctat agtcttcagg 281761 gtctgtgtca gacattttgg tatcaccttg atacaatgtg aaatccatac tgtctacatt 281821 cagcgggtct tttcctgtgt ttttcaccgc gacattgact tttaacacaa gctggtcatc 281881 tgaagtggac ttatcatatt tagacggaag tgtgtaagag acatccttga ttttgacttg 281941 agctatatct gagctttttt ctgtttctga ttctttcttc tccgcgcttg ttttgctgcc 282001 ggaacaagca gctgtaaaca tcatcagcag aagaattagg aaaacagcgt acgttttttt 282061 ctgaaacatt catttttcct cctcaaatgg tttaggaaag gggagtcttt tgtctttgag 282121 aaatggatct ttttgaatgg attagcatca tataaccaaa aaaatcagtt cttttctcac 282181 ggttttcacc ggattttctg gaaactccgc cctcctttgt catgaatgga cctataaaaa 282241 gttacaacgg aattaatttt aagattatta gcttttatat tgaataggtt catcatccta 282301 tttttggtga aaaatgttct ggtaaaactg gtaaactcag aaaactgtgt attttagact 282361 attacttttt gattagttgg agggaactta agaaggatga aaggggccgc ctttgtgaag 282421 aaagagggac tgaaacaaaa agcactggaa atcggccggg tgccgacaca cttaaaactg 282481 gaaattgaag attatggcgg tgatgataaa agagctcatt tttgttgggc agatcctcag 282541 gatgagaata ccggcattat cgtggagctt ggaccggacg gagagctgga atccctttcc 282601 cgtgatattg agcctgaaag cggagaaagg ctgtctgagg agaaactaga ggatatcatg 282661 cgccaatttg tcgagactca tcatccgggg gcactctctg cctttgttcg tgaagaaaat 282721 gaccgtgcat acggcgataa agtgagattt tcatatgttc aaatggaggc tgggcttcct 282781 ctccccatga gcggatttat ggctgatgtt tccttatcag gtgagattgt ttacttccgt 282841 tattacggcg aagcgggcag catcatcaag ccaaagcggg tcgcggatgt tgaagaggca 282901 cttgccttta tcaagaagga cgtggagttc gaccttttgt ttgaggttct ccatcgttct 282961 gtttacaaaa acggagatga tcagccgcat ttggtgtacg agcctgaagg tagggcgatt 283021 accgtacctg cggatttggt tcaagaagaa caagcagttg atgatgacga tgattacagg 283081 gagccggaga gctttcctct ccctttattc gagggcatcc gcgaaaaggc cgatcctgac 283141 agcatgattg gtattgaaaa tgggtttgtc aaagagcggg aagcggattt gggagatggg 283201 agaattggaa tcgtttggcg gaatccggat gaccctgtgt atcagccggc ggataaaagc 283261 atggacagct ggtttaaggg acggactcat caagtgctga aaaccatcta taacaaagaa 283321 accggaaaac tcgaaggcgt catgtcattt atggagaaaa aagggccgct gacagtaacc 283381 ttggcagagt gtgaaaaaat cgcgcttcgc tttctatttg ctttatttcc gaatgccgat 283441 caatatttta ggatcagata cgacgaaaaa gatgaagaag aaaacgcagt cgctggtttt 283501 acgtttgaag cgcattgtca cggagttccg ctccgatttg ggcagatcag aatttgtgtc 283561 agccgccaga cagggtatat caccgtttat atgggaccgg atattgaccc aaataagctg 283621 gcaaccattg atcctgtgcc ggctatttca gttgaacaag ccaagtctat cttttggcag 283681 cattttaaag ttgagcttgg ctgggaaaga gagtacgggg atgatgaaga acacagctac 283741 cggctcgtct ataagccggt gtatccgcat tttatcgatg cacatacagg ggagcctgtc 283801 ttcagcatat ggtgaaacag ccaaaagtca cgcaattgcc tcagatatag aagagagtat 283861 gtgatgaaag taacagaaag aatctcaaaa aacaatgaca ataatagaaa aggacctttc 283921 ttcactttaa atgaagaaag gtctttttat ataataaaca ggattctctt tgtcgtagac 283981 tctttgaaag ggatgacttc attggttaat aaacagctga aaaagaaggc gcaggagatc 284041 ggaaatgtac cgacgcatta tgagcttgag atagaagatt acgaccaaaa gcaaaagaag 284101 tacgggcagg catattttat ctggaaggac cctaaagatc cggaaaagca cattacagtt 284161 gaacttagaa atgacggcgc cttgctcacc ttttcaacaa ctgtccactc cgagacagac 284221 aaaaaacttc cagatgccga gctgaagctg acggctcttc agtttgccgc tgccaatcat 284281 cccggcacat ttatgaattt tcattttcaa ggcaaggaag aaagggggca gcacatccgg 284341 tttgtctata ccaaaatgga gctggggctt ccgattccca attcaggctt tttaattgat 284401 atgacacgaa gcggtcagat tgtccacttt ctatattacg gggaagggca taaagccgaa 284461 gttccgacgg aatttgtagc aaaagagaag gttgtatccc attacttaaa cacaatgtct 284521 tttgagctga tgtacgatgt cattgatggc gaacaggaac caaggcttgt atatgaaccg 284581 attctaccgg gatacagcta tcccgcagat gtagacgaaa ttgtgcccga ccagcatatc 284641 gcagatgaaa gaatagaaaa cacggcgcca ctgccgccgc ttcagaacaa ggaagaagtt 284701 gatatatttg ccttgctggg ttttacctct gatatgcaga aagtcagtga aagagacttt 284761 ggagaacaaa ttggaagcac gtggcgcagg ggcgctgcgc cggagcgtaa ggatttaagc 284821 ataggaagct attttgaaac gagaaataaa aatacaatca aaatgaagac ggataaaaga 284881 accggaaaat taaaagcagc gctttctttt atggactggc ggaacaacct ccaatgctcc 284941 acggaagaat gccaagagat agcgcttcaa tttttgtatg ccctctatcc gagagcggct 285001 gagtttttca gggtgaatcc cgtccgaatt gatgaaagag ggagagtccg caaccatttt 285061 tctgtctggt ataaaggagt gccgctgcgg ttcggcgctg cccgcatcat tgtcaatccg 285121 gaaactgggt tgattgacgc ttttatggcg cctgatattg aacctgaaca attggaagcg 285181 ataaatcaca ggccggatgt ttccgctgaa gaagcgaaag aagcattttt agccgctttt 285241 gatgtgaaac tggaatggca gcctgatttt acagcaggca gtgaccagca ctgcaaactt 285301 gtctataagc cggtttaccc ttcctatatt gatgcgcaca taaggaaaaa gaaaaggctg 285361 tgaggggtgt ctagttagga atcatctcca agtgggggta gtccttgaat cgtttccaat 285421 ccccgcccca ttcgaaaccg agtgtcttag cgatctcgac aacctccagc caatctgatt 285481 ttccgttttg attgccgtca tattccatat cccatatgat gctgccatcc tttttttgaa 285541 gggcgaaatc aatcgctaaa ccatagttat gatacgattc ccctcctctt gcataggtga 285601 caatattccc tttttttgta cgtccctgtt tatataattc atcttgttcc ttaaaggacc 285661 tgaatccttc agtaatgacg acgtcaatgc ctttattcgc tgcagcggct ttgagtgcat 285721 cggcattctg cttcacaatc ggatgaagat ccgaggggac aggcatgtcc tgcaaggcgt 285781 tttgagaatg ccattcatgc cgaatataac taaaacaaag atctagaaga aatagaatac 285841 ataagataac aaatgttttt gcgggtaagt tcatatcggt ctcactttct caagatgtgc 285901 tgaatgttaa cgcttttaag tgattgactc tctctaaaag cgaacagcta tgataaaata 285961 taacataaat agtagcagga ggaaggaggc agaccgatga gagcaaagat tccatcagaa 286021 gaagtagcag taaagctgaa tgaatggtac aagctcattc gcgcatttga agcagatcaa 286081 gcagaagcgt taaagcagga gattgaatat gatttagaag atatggaaga gaatcaggac 286141 ttgcttttat atttttcttt gatggaattc cggcatcgaa tcatgcttga taagctgatg 286201 ccggtgaaag acagcgatac caagcctccg ttctctgata tgctgaacga aattgaaagc 286261 aatcagcaaa aactcacggg cttactggaa tactactttt attatttcag aggaatgtac 286321 gaattcaagc agaaaaattt catattagcg attgaccatt ataaacatgc cgaggaaaag 286381 ctcgagtatg tcgaggatga gatcgaaaaa gctgagtttc tttttaaagt cgcagaagtg 286441 tattatcaca tcaaacaaac gtatttttcc atgaattatg cgagccaggc gcttgatatc 286501 tatacgaaat atgaactgta cggtcgccgc cgggttcagt gtgaatttat catcgccgga 286561 aatttgaccg atgtgtatca tcatgaaaaa gcactgaccc acttgtgcag cgctttagaa 286621 catgccaggc agcttgaaga agcgtacatg atcgctgctg cctattataa tgtcggacac 286681 tgtaagtaca gtctgggtga ttacaaagaa gcggagggct atttcaaaac agccgccgcc 286741 atttttgagg agcacaactt tcagcaagct gttcaagctg tattttcact gacccatatc 286801 tactgtaaag agggaaaata cgacaaggca gtagaggctt atgaccgcgg gataaagagc 286861 gcggctgaat gggaggatga catgtacttg acgaaattcc gcctcattca tgagctgtat 286921 cttggaagcg gcgacctgaa cgtgcttaca gaatgctttg acctgctgga atccaggcag 286981 cttcttgctg acgccgaaga tctgctgcat gatacagcgg aacgtttcaa tcagttggaa 287041 cattacgagt ccgccgcttt cttttaccgc aggctgatga atattaaaaa gaagcttgcc 287101 gagcagcgtt ttcaatagga aatggcagag aactacaggt tctctgcttt ttttgtgctg 287161 ttttcaactc ggaaaaacag ggtattttcc actgcatagt gagaaacaga ggaggatatc 287221 aagtatgtac aaagatttaa ccggaaaaac agcgattgtg acagggtctt caaaaggaat 287281 cgggaaagcc attgcggaac ggttcggaaa ggagaaaatg aatgttgttg taaattacca 287341 cagcgacccg tctggagcag atgaaactct ggaaatcatt aagcagaacg gagggaaagc 287401 cgtctcagtt gaggcggacg tgtcaaaaga agaggggatt caggcgctct tggacacagc 287461 tttagagcat ttcggcacgc tcgatgtgat ggtaaacaac tccggtttta acggcgttga 287521 ggcgatgccg catgagatga gtcttgaaga ttggcagaga gtgattgatg tcaatgttac 287581 cggaaccttt ctgggagcga aagcagcact taaccacatg atgaaaaaca atatcaaggg 287641 caatgtgctg aatatctcaa gtgttcatca gcagattccg cgccctgtaa acgttcagta 287701 ttccacatcc aaaggcggca tcaagatgat gacggaaacg ctggcgctca attatgcgga 287761 taagggaatc cgcgtcaatg cgatagcgcc cggcaccatt gccacagaat caaatgttga 287821 tacgaaaaag gaagagagca ggcaaaaaca attgaaaaaa atcccgatga aagccttcgg 287881 aaagcctgaa gaagtggcgg cagcagcagc ttggctcgta tctgaggaag caagctatgt 287941 gaccggcgca acacttttcg tcgacggcgg aatgacactt tatccatctc agcttgaata 288001 gaagacaaaa cagggggatt gcgggatgaa aacagactgg tggaaggatg cagtggtgta 288061 ccaaatttac ccgagaagct ttcaggacag caatggagac ggaattgggg acttgcgggg 288121 gattatttcc cgtcttgact acataaagga gctcggggca gatgtgattt ggatttgccc 288181 gatctatcct tctccgaatg ttgattacgg ctatgatgtg acaaaccata aggcgattat 288241 ggattcttac ggaacaatgg acgattttca cgagctgctg gaccaggtgc atcagcgggg 288301 attaaagctg gtgatggact ttgtgttaaa tcacacctcg gtcgagcatc cgtggtttaa 288361 agaagcggag ctggacaaaa acagcaaata ccgtagctat tattattggc gtcccggcac 288421 aaagaacggc ccgccgacgg actggctctc aaactatgga tgcccggtct ggcaatacga 288481 agagcacacc ggagaatact atctccatat gaatgccgtc aaacaagctg atttaaactg 288541 ggaaaatccc gaagttcgcc aggcggtgta tgacatgatg aaattttggc tcgataaagg 288601 ggtcgacggt ttgcgaattg atcagctcca tctcatttct aagaaagaat atcttccttc 288661 gtatgaggac tatatcaatc agcaggcaga gccgaagccc tttcagccaa atggcgaacg 288721 aatccatgac tatttaaaag aaatcacaga tgaagtgttt tctcattatg atgtcatgtc 288781 tgtcggagag gtcggcagtg tcacaccgga agaaggcctg aaatatacgg gaacagataa 288841 gcatgagctg aatatgattt ttcactttca gcatatggag cttgatcagc agcccggaaa 288901 agaacattgg gatttgaagc cccttgagct ttctgattta aaatcggttt tgacaaaatg 288961 gcaaaagaag cttgaacatc aaggctggaa tacattgttt tggtgcaacc acgaccagcc 289021 ccggattgtg tccagattcg gagacgatgg ggaataccgc aaagcatcag cgaaaatgct 289081 ggcagccgta atttatttta tgaagggcac gccgtatatt tatcagggag aagaaatcgg 289141 gatgacaaac gcgccgttca cccggattga agactacaaa gatatccaaa cgatcaatat 289201 gtatcataaa cgggtgtttg aaaaaggcta tgatccaaat gatgtgatga gatcgatctt 289261 agccaaaagc cgggatcacg cccggacccc gatgcagtgg aacagcggca aaaatgccgg 289321 atttactgac ggcacgcctt ggctgaaggt caatccgaac ttcaccgcaa tcaatgtgga 289381 ggaagcgcag ggagatcctg attctgtctt aaactattac aaaaagctga tcagcctgag 289441 aaagcagtac gctgacctca tgaaagggag ctttgatctt ttgcttccgg acgatccgca 289501 gttgtttgta tacatgagag aaaacagtaa acaacagctt ttgtcggtca ataatttttc 289561 aaaagagcag gctgtttttc agtggcctaa gaactgcggc aaagctcagg cctcactgct 289621 tctcagcaat tataacaacg atgatcttga tgacgaaatg gtgttccggc cttatgagag 289681 cagggtctat cttctggaca aaacaaacta atgattgaag tagcccggca tttttagccg 289741 ggttttttta gtacatatat tcgctctgca ggcgggaaga ataaatgaaa atgaaattta 289801 ttcttgcaaa acgtaatgac ttcggtttat tatgatatag gattacaaaa tcgttatcat 289861 tttgatttaa agttactgaa aaagagggga tatacgatat gtttaaaaaa tggagcggtt 289921 tgtttgtgat tgcagcgtgc tttttattag ttgcagcatg cggcaactca tcaacaaaag 289981 ggtcggcgga ttcaaagggt gataaactgc acgttgtcac aacgttctac ccgatgtatg 290041 aattcacaaa acaaattgta aaagacaaag gcgatgtgga tctgttaatc ccatcttccg 290101 ttgaaccgca tgattgggaa ccgacgccga aagacattgc caacattcag gatgctgatt 290161 tgttcgttta taatagtgaa tacatggaga catgggttcc gtcagctgaa aaaagcatgg 290221 gccaaggcca tgccgttttc gttaatgcaa gcaaaggcat tgatttaatg gaaggctctg 290281 aagaagaaca cgaagagcat gatcatgggg agcatgagca cagtcatgca atggaccctc 290341 acgtatggct tagccctgtt ctggcacaga aggaagttaa aaatattacg gctcaaatcg 290401 tgaagcagga cccggataac aaagaatact atgagaaaaa tagtaaagaa tatattgcaa 290461 aactgcagga tcttgataaa ctatatcgta caaccgcaaa aaaagcggag aaaaaagaat 290521 ttatcacgca gcatacagct tttggctatc tggcaaaaga atacggcttg aagcaggttc 290581 cgattgcagg gctttcacct gaccaagaac cgagcgcagc cagcttggca aagctgaaaa 290641 catatgccaa agaacataat gtaaaagtta tttactttga agaaattgca tcctcaaagg 290701 tcgcagatac gctcgccagt gaaatcggcg cgaagacaga agtgctgaat acactggaag 290761 gcttgagcaa agaagaacag gataaaggtt tagggtatat cgacattatg aaacaaaacc 290821 tcgatgccct gaaagattca ctattggtta aatcataaga tagtgtgcgc cggaggggtg 290881 cacactattt ctttgtgaga aaggaagatt aacatgaatc tcgtctcatt gaaagatatc 290941 gttttcggct attcccatac gcctgtttta gataaagtat cacttgatat tgaaagcggt 291001 gagttcgtcg gcatcactgg accaaacggc gcctctaaat cgacgctcat aaaggtaatg 291061 ctcggcatgc tgaaaccgtg ggaaggcaca gtgacgatca gtaaaaggaa tacagaaggg 291121 aaacgcctga ccatagggta cgtcccgcag caaatttctt catttaatgc cggatttccg 291181 agcacggtgc tggagcttgt tcagtcaggc cgctatacaa aagggaaatg gtttaaacgt 291241 ttaaatgaag aagatcatct tgaagtagaa aaagcattga aaatggtgga aatgtgggac 291301 ctccgccatc gtaaaatcgg tgatttatca ggcggacaga aacagaaaat ctgtatcgcc 291361 agaatgctcg ccagcaaccc ggatctgctg atgctggacg aaccgacgac agctgttgat 291421 tacgacagca gaaaaggatt ttacgaattt atgcatcatc tcgtgaaaaa tcacaaccgc 291481 acagttgtga tggttactca cgaacaaaac gaagtacagc aatttttaga taaagtgatt 291541 cgattagaga gaggagaaaa aggcggatgg aaatgtttga cttggaattc atgcgacgag 291601 cttttctagc aggcggcatg atcgccgtca tggctccgat actaggagtg tatctcgttc 291661 tcagaagaca ggccttaatg gctgacacac tttcacatat ctcattgtca ggtgttgcca 291721 tcggcttttt tctcagcacc aatataaccg cagcaagcat agtcgtcgtg accatcggcg 291781 cgatcggaat tgaatacatg cggcgggcgt atcggactta ttcagaagtg tccattgcca 291841 tcttaatggc agctggtttg tccttcgcga tgtttttaat cagcctttcc aaaggcacag 291901 ccaatatgag catcgatcaa tacctatttg gatcgcttgt gacagtaaac cagcagcagg 291961 tctatattat cagtattatc acactgctga tcctgcttta ttttattgta ctgagaaggc 292021 cgctctacct gctgacgttt gatgaagcta cagccaaaac atcgggaatc aatacaaacg 292081 ttctctcgtt gtcattcagt attgtcacag gccttgcgat ttcagtcatt attccgatca 292141 tcggggtcct tcttgtatcg gccctgctcg tattgccggc agccttcgcc atcagaattg 292201 caaaaggctt taacatggtt ttcattacag ccatactcat ttcattattc agcgtattta 292261 cgggactgac atcatcctat cagctcggga cgccgccagg tccgtctatt accctgctat 292321 tgatcgtttt gctattaatc ggatttgcag ttcagggagt ttggacgttt atcaaaaaag 292381 aagctcagcg caaaaaaaga agccgataac atgaaaagca gttttcccta gggaaaactg 292441 ctttttttat agaaacaatt cggcaaggcg ctcataagat tcttttttcg cctcaaaatc 292501 aaacacattg cacagaacca tgatttcatt tgtttcgtag cagcctgtga ggtctaacag 292561 ctgttgtttg acagtggtgg gagaaccgat caccatccgc tttctgtttt cttctatgag 292621 ttttttatcg gacgctgtat agggatgagc tttcgcttcc tcgatgcttg gcacgcggct 292681 gtccaagcct tttccgacgc gaagaagcca cagatcctgg cttaatgcga gttcttctgc 292741 ctcttcatct gtttttgcgc aaatgacaaa aatcgtaaac agtgcggatg gattcgaaaa 292801 atgggctgag ggccgaaagc tttcccggta gatgcggaat gcattttctc ctcgctcggg 292861 attaatgaaa tgcccaaata catatccaat cccctggtgc gccgcgcgtc ttgcgctgtt 292921 ttcaccaaga ccgagcaccc atagctcggg tgccgtacca ataaggggcg ccgctttgat 292981 tccggcatac ggatggtcgg gaggaaggga atctgttaga aaataagaga catcctgcag 293041 ctgtctgtta aattcggtta agcttttttt caccccgtcc gttaatgcaa gtctggtttt 293101 tgtcgtgccg ccgggggagc gaccgacgcc gaggtcaatc cggtttggat acagggcctc 293161 aagctggcga aaggtttcag ccactttaaa tgggctgtat tggggcagaa gcacgccgcc 293221 tgatccgaca cgaatggtgt ttgtctgtgc tgcgatgcgg gcgatcatga tttcaggcgc 293281 tgtgcttgcc agtcctttcg tgctgtgatg ctcggcaaac caataacgct tatagcccca 293341 ctgttcgctt aattgggcaa gctcaaccga atgctggaga gttgtcacag ggctttctcc 293401 tttagaaaca ggtgcctgat caagtatgct taaatgaatc aaaaggccgc ttcctttctg 293461 tctgttttta gatggtgaca ccagaatagg caaaatgact tgcccgcgtc aaatggtttg 293521 tttaagaagc gcactttata gcatttgcaa atcatatatc aaatatggaa gttttttttc 293581 gaggtttttc gtcaattatt cttaactttt acgaaacttt gatataataa caaacgtata 293641 tattagtaat ttacggctta ttttccttgt gagcgtaaaa ataaatgtga ctatcttcac 293701 attttgatga gtaggagtga atcgtgtggc aatttcttta gaaaaaggtc aacgaattga 293761 tttaacaaaa ggaaaagccg gtctgtcaaa attgatggtc ggtctcggct gggacccagt 293821 gtcctcaggc ggaggattct tcagcaaact gcttggcgga ggcggtccga atatcgactg 293881 tgacgcttca gtgctgatgc tggaaaacgg aaaattcacc gataagaaaa acctgattta 293941 tttcggcaac ctgaaaagcc gctgcggcgg tgtacagcat acaggcgaca acctgacggg 294001 tgacggtgcg ggcgatgacg agcaaattat gatagattta gataaagtgc ctggaaacat 294061 cgataagctt gtatttgtag tgaacattta cgattgtgtc agaagaaaac aagatttcgg 294121 catgattcaa aatgcgttta tccgcgtagt tgatcaatct aatcacgagg aaatgctcaa 294181 gtacaatttg agagacaatt acgccggcag aacaagcctg attacagcag aaatctaccg 294241 cagcggcagt gagtggaagt ttgcggcggt cggtgaaggc acaaacgata cgagattaga 294301 agatattatc agtcgatacg tataaaagaa aaggagtgga tgaaacatga caatttcatt 294361 ggcaaaagga caaaaagtag atttaacaaa aacaaatccg ggtctttcaa aggttgttgt 294421 cggtttaggc tgggatacga acaagtatga cggcgggcac gactttgatc ttgactcaag 294481 tgtgtttctg ttagacgccg cgggcaaatg cgcgtcacca aacgacttta ttttctacaa 294541 ccagcttgaa ggcggcaacg gttcagtcgt tcattcaggc gacaacctga ctggtgctgg 294601 cgaaggcgac gatgagaatg taaaagtaaa tctcagcgct gtaccggcaa acattgataa 294661 aatctcattt gttattacca ttcacgatgc agaagcgcgc agccaaaact ttggacaagt 294721 atcaaacgcg tttgtccgca tcgtaaatga agaaacaaat gaagagctca tccgttacga 294781 tcttgcagaa gatttctcta ttgaaacggc aatcattgca ggggagcttt acagacataa 294841 cggcgagtgg aaattctcag caatcggctc aggctaccaa ggcggccttg cccgcattgc 294901 aacagactac ggtttgcaag tcggttaaga caaatacgaa gagcagaaag gagagaggca 294961 gtatggccat tcaattatca aaaggacagc gcattgattt aacaaaaaca aatccgggac 295021 tgactaaagc ggtgatcggc ttaggctggg atacaaacaa gtactccggc ggacacgatt 295081 ttgacctgga tgcttcggcc tttttagttg atgcgcatga taactgcgta aatgatctcg 295141 atttcgtctt ctataataac cttgaacatc cgagcggcgg tgtcatccat acgggtgaca 295201 accgcacggg tgagggcgac ggagatgatg agcagattat cgttgatttc tcaaaaatcc 295261 ctgctcacat tgagaaaatc ggcatcacag tgaccattca cgacgctgaa gcacgcagcc 295321 aaaactttgg acaagtttcc aatgcatttg tccgcgttgt ggatgaagaa acgcagaatg 295381 agcttcttcg cttcgatttg ggagaagact tctccattga aacagctgtt gtcgtttgtg 295441 agctttacag acacggcggc gagtggaaat tcaatgcaat cggcagcgga ttttccggcg 295501 ggctggctgc attgtgccgg aattacggtt tgcaagtgta agcgagtgac aaatagagaa 295561 gtcaccgttt caaattatag gaggaaaaaa cttggacttt ttacatcata ttttgtctac 295621 gtatgcttca tttttcgatt ggaaaatgtg gggggaagtt ctgactgatc ctgtttcctg 295681 gggtttgatc ggttcccttg ttgttctgga aggcctttta tcggccgata acgcgcttgt 295741 tcttgcggtc atggttaaac acctgccgga aaaacagcgg aaaaaagcgt taacgtatgg 295801 tttgtttgga gcttatattt tcaggtttat tttcatcggg ctcggtatgc ttctcattaa 295861 attctggtgg atcaaggtgc ttggcgcgct ttacctggct tggctcgtca ttaagcactt 295921 ctggataggc gaaaaagaag aggaagcgga cggcatgaag aaaaactctt ggatggtccg 295981 cacgttcggg atcttctggg cgactgtcat ttcagtagaa ttaatggatc ttgccttctc 296041 tgtggacagc atcctggccg cgtttgcagt atctgaaaaa gtatgggtgc ttctgattgg 296101 cggtatgctt ggtattttaa tgatgcgtac agtggcaaaa gtgttccttg tgctgattga 296161 taaaattcct gagctggaaa acacagcatt cgtcttaatc ggcattatcg cgctgaaaat 296221 ggcggggagc gctttccatt acgaaatgcc gcactctgta ttcttcatta tcattatcgc 296281 tgcatttgcg gtaacattga tcattcacta catcaataaa caaaagcagg tgcgcgaaca 296341 aacagccgct tcaaaagaag aataaaacaa aacaaggagg gaggttcaat gtccttcctt 296401 ttttgttacc gaaatatcgt ttcaatgaca aaccggaaag gaggatatga tgagacaaga 296461 agaactaacc attcataaag cacttccggc tgatggcgat tggaaaagcc tgctgtttca 296521 gccattgccg gagcgggatc actatgaaac tgcacaaggc ctttcttttt ctcgtcttgc 296581 cggtcagata ttgggcacgc ctattgatga gacggactac tataacgagc tgtatgagct 296641 gtctgtaaac gaccgcataa cgattttgag tgaaacgctt gataaaacaa tcgaaccgga 296701 aacatttcaa aagcttcagc atattcattc catcaatcag aaagaaaaag ggctgtcagt 296761 cagccgcttt gttgcctttc tggacgggga aaagctgatt gcgaagcact caaatccctt 296821 gatgcaccgc catttaagaa aagcgttgat gacgctttta catacctttg cggacagtca 296881 tgaaaagggg ctgaatcatc ctgattttcg cagagtgctg cttgatgtct cgaagttttc 296941 cttaaaccat ctgaaccctt ggctggaaaa aaccgatata gagcgggaga tgccgaaggt 297001 tgtttggtat ggagatgcga cgaaaagcca gctctatttc ttatattatc tgatgctggt 297061 cggctgtgat gtactgctgt tccatccggc gggaacggat cagctggcgc ttgtcgaccc 297121 gaagcaggag ctcggtttta cggaaaagct cccggatgtt tcggagcttc agccgtttcc 297181 gaaagaaaaa ccagaccgga aatcaacagt ggcttaccgc tcaacaaagg aaattgaaca 297241 tgtgctgaat cacgaggaat ccatgctata taagccgtgg cagttcagag atcacacacc 297301 ggtgtccgtt acgctgaaaa cgacctatga tgaattgttt ttaatcacga aagaacgcgc 297361 ctttattcgg ccgaatttca aagctgataa acattccatt gagattccga atgtattcgc 297421 caaaattatg ggcgtgtcga aagacaataa ggaatattgg aacaggcttc atactctagc 297481 ggattatcag gaaacagaaa tggtcagaag ctttccattt acagaagaaa taaagtcgaa 297541 ctatcaattt cactacagcc acgcacttga tcaagaaggg aacattgatc cggacaagct 297601 gatggcaagc aatgtgtggc agtacaaaca gctgccggcg ggcgttcaga ctgccattgc 297661 caaaacgatt tcgagaatgt gcaggtaccc gcggcttaaa gccttgcatc aggaacaagt 297721 caaggatgtt caaatctatt tgtttaaaca aacaacaaac ctgcctgcta atctgctgaa 297781 attgattcaa atgttcgact atgcgcaaac cgttccgaaa ctcgttttat atcatacgga 297841 aatgagcggc ggactcacgc gttcggatgc tgccgccctg ctgttcctga atgaaatcgg 297901 aatcgatatc atcatttata atccgcccgg acaccaagat attgagcagt ttattgaaga 297961 ggatcagtat gatatccact ggctggatga catggtgttt cagcaggact acaaagagcc 298021 ttcgcttgtg aaaaggctct tcagaaccat tacccaaaaa taaggagaga agaaaagcat 298081 gacaacagaa aatcaaaatc cgcttgttct cgataaaaat gaagagattt cccagcaaaa 298141 agctgacgat atccgtcttc agctccgtca ggaaccagaa gtgaagcggc ttgctcaaca 298201 aattgacgtc aaaaaccaaa tggagctgct tgagtacggc aaggagccgg ccgttgaaat 298261 atccaagttc tctgaccgca tcttggggat gatgaaaaca acaagcgtga cagactccgg 298321 cacaatgctg actcagcttg ggaaaatcat ggaccgcttc gacaaaaatg attttgatga 298381 gccaaaggga ttaatggcga aaattttcaa acgcggcggc agcatgattg aaaaaatctt 298441 taaaaagtat cagacgcttg gcggagagat tgaaaaaatc cacgttgaga tttcaaaata 298501 caaagatgag atgacgaaga cgaactacac gctcgatgaa atgtatgaaa acaatatcaa 298561 atactatatg gagcttgaaa aatacgtcgt tgccgggcag atgaaactgg aagagatgca 298621 gtcgatcctt ccttcatatg aggaaaaagc ggcaagcggg aaccagctgg cgcaaatgca 298681 gctcgatacg ttgcgcaacg gcattcaggc gcttgaggaa cgggtgtatg atcttgacat 298741 ggcacggatg gtggcgcttc aaaccgcacc tcaaatccgt ctcctgcagc gaggaaatgc 298801 aaagctgatc gggaaaatca actccgcgtt tatcattacc attccgattt tcaaaaacgg 298861 cattattcag gctgttacgg taaagcggca aaagcttgtg gctgattcca tgagcgagct 298921 tgaccgccgg acaaacgaga tgctgaaacg aaatgctgaa aacatctcga gccaaagtgt 298981 tgaaattgcg agaatggccg gcagaccgag catagatatt gaaacgattg aatcgtcttg 299041 gaacacgatt gtcagcggca tgcaggaaac aaaacaaatc gaagaagaaa acaagcgcct 299101 ccgcgaagac ggcgcgagac gaattgccca gcttcaggat aatattaaaa aagcagcatt 299161 gcagcaataa taaaaacccc gcttgtggaa cataagcggg gtatttcaat tacatcattt 299221 agttaatgac aatgtgtaaa gacaggtgta aacttaaacg gtaatcattt tgcatatcag 299281 aggtgttggc aatgggaaaa caacagccta tatcccagcg taaactgctg ggcgtcgccg 299341 gtttggggtg gctgtttgat gcaatggatg tcggaatatt atcgtttatt atcgccgcgc 299401 tccatgtaga gtggaatctg tcgcccgaag aaatgaaatg gatcggaagc gtcaattcca 299461 tcggcatggc tgcgggtgcg tttttgtttg gtttgcttgc tgatcgaatc ggccgcaaaa 299521 aagtgttcat catcaccctt ttatgctttt ccatcggaag cggcatttcc gcttttgtga 299581 cgagcttatc ggcatttcta atccttcgtt tcgtgattgg tatgggactt ggcggcgagc 299641 ttccagtcgc ttcaacactc gtttcggaag cggttgtgcc tgaaaagcgg ggcagagtga 299701 ttgtgctttt ggaaagcttt tgggccgtgg gctggctcgc agcggccttg atttcttact 299761 ttgtgatacc aagcttcggc tggcaggctg cccttctgtt aactgcgctg actgcttttt 299821 atgcgctgta cctgcggacg agtctacctg attcgccgaa atatgaatcg ctttctgcca 299881 aaaagaggtc gatgtgggag aatgtaaaaa gcgtctgggc aagacagtat atacggccga 299941 cggtgatgct gtcgatcgtt tggttctgtg tggtgttttc ttattacggc atgttcctat 300001 ggctcccgag tgtcatgctg ctgaaaggct tcagcatgat tcaaagcttt gaatatgtcc 300061 tgctgatgac gcttgctcag ctacctggct atttctctgc cgcatggctg attgaaaaag 300121 cgggccggaa gtggatactc gtcgtttact tgattggcac agcaggaagc gcctatttct 300181 tcggaacggc ggattcctta agtcttctgc ttacggctgg agtgctgtta tcgtttttca 300241 atctcggtgc gtggggcgtg ctgtatgctt ataccccgga gcaatacccg actgcgattc 300301 gagcaacagg ttcaggaacg acagcagcgt ttggaagaat cggcggcatc ttcgggcctt 300361 tgctcgtcgg aaccctggca gcccgtcata tttcgttttc ggtcatcttt tcaatctttt 300421 gcattgcaat cttacttgcg gttgcttgta ttttgattat ggggaaagaa acgaaacaaa 300481 ctgagctaga ataggaaaag cacctcttaa aagaggtgct ttcagcgtgt cgacaaaccc 300541 tcgcattcgt tgtcaggact gcgcttcggt gctcaatgcg aagtggatca acggctaaat 300601 tctcaggcgt cctgcctaaa cgccgtcgtc atcacatcct gtgaatgtcc gctcctatgc 300661 tcgtccttcc tagacttcaa gggttttcaa tcacgctgaa aagattttgt caacaatctg 300721 aggcacctct tgaatgaggt gcttttttac aattgcgccc gggctgtgga ttggcgtttc 300781 ccggttttac tgattgtctg gtagagcgtc atagaaagta tgaacagaat ggcagtaaat 300841 cctgtgacag ctccgaaatg ctgtgtgctt tgatataaaa aacctgcaat acttgtaccg 300901 acagtggttc cggcatacat agcggcattg gaaagggaag cgatggttcc tcgcgcattt 300961 ggtgcaatgg attgaaagac acccatcatt aacggaaaga tgatgccagc tgtaaagaac 301021 gtgagaaaaa agccggcttc tactaaaaac aagtttggaa agaacggaag agcgaaatag 301081 agagcgccca ttagcagcat cccgctgatc agtgttttaa acatgcccag cttttctgaa 301141 acccggctgc cgataaggct cccgagcata tttcccagtc cgagtacaag catagctgcg 301201 ccaatttgtg acacggttaa atgataatcc gcggaaagcc aagtacccag aaagctgaac 301261 gatgcgaagt ttccggtttg aaacagaaaa taggcaagca gaatgaccga tgttttcggc 301321 aatgaaaaaa gctcccgata ggggttgaca attgatgggc gcgccaatgg ttcagaaggc 301381 cggatgccag gcatgaccgc cgccaggatc aatagaagaa taagcgagca cgctgacaaa 301441 acgaaaaatg gcgtatgcca tgtaaaggaa gcgagaaacc ctccaatagg aagtccgagc 301501 atttgtgaag cggccaaacc tgctgtcgca atccccatgc cttttatgat ctgagaaggc 301561 tggacaatga ctgggatgga cgcccaaatt tgaggcgtca caaacgcagc gctaacgcct 301621 gcggcaaaac ggaacaggca catggcggca aaagagggag cgatgccgca taaaaatgtg 301681 gatacgataa agcctgcaag tccccacagc atgactgttt tcctgttcag ccggtctgag 301741 attgggcctg caatgaaagc gaagagtgca taaccgagtg cataagcact gaccatccag 301801 cctgacaaat cagtagagac atgaaactga tcctgtaaaa gggggagaag cggcgaaagc 301861 aaaaaggtat ccgtgccaat gacaaacatg acactgaaga aaagccaaat gcgattcaaa 301921 ttttatcact cctattgttt tataacttta aaactatgaa acagatatgt atagagaaaa 301981 ccctttgtta gagggtttcc aaaaagccag gcaggtatgt ttgaaatgtg tcttcacgca 302041 gactgacgta ttttgtccgc gaatctttcc gggttgccgt caatcccgct tcacgcagcg 302101 ttttaaaatg ataagatgcc gtggttttga caatattgca cttttcacct acttcaccgc 302161 agctgagttc ttttccgctg acataaagcg tacgaataat ggcaagcctt gattcatcag 302221 acagtgcttt aaaaatttgc gctctgattt gatcatctga ttgtttcata gtcatgaaac 302281 tataatacat aatgggtgtt gaaaaagcaa cttatttttc cagtaaagga gcaggaagtc 302341 ataagaggaa ggaggaattc aattccaata aaagcgtttt caactaaagg taggagaaaa 302401 atcacccgta aaatacaatc atataggagg attacagagc atttagaagc ataaataaga 302461 tcatgtggtc acatggatgt ttataaagaa atggtacaga ataaaagaga atatgctgtt 302521 tgtgtgggaa gttacataaa tgttacggta ataaagattg cttaatatgg agggaaaata 302581 tgagtgtaga tgagaaacca attaagataa aagtcgagaa agtctctaag atttttggga 302641 aacaaacaaa gaaggcagtt caaatgcttg ccaacggaaa gacaaaaaaa gagatcctga 302701 aagcaaccgg atcaaccgtt ggggttaatc aggcagattt tgaagtatat gatggtgaga 302761 tatttgtcat catgggtcta tcagggagcg gtaaatcaac tttagtacgg atgttaaacc 302821 ggcttattga accgactgcc ggaaatattt acattgatgg tgacatgata acaaatatgt 302881 caaaagacca gctccgggaa gtccgccgga aaaaaatcag catggtcttc caaaagttcg 302941 ctctgtttcc gcacagaacg atacttgaaa acacagaata cggactggag cttcaaggtg 303001 tagacaaaca agagcggcag caaaaagcgc ttgagtctct taagctcgtt ggactggaag 303061 gatttgaaca ccaatatccc gaccagcttt ccggcgggat gcagcagcgt gtcggccttg 303121 cccgcgcgtt gacgaatgac ccggacatcc ttctgatgga cgaagcgttc agtgcgctcg 303181 atccactgat tcgtaaagat atgcaggatg agcttcttga tcttcacgat aatgtcggaa 303241 aaacaattat ctttattacg catgacttgg acgaagcgtt gcggatcggc gacagaattg 303301 tcctaatgaa ggacggcaac atcgttcaaa tcggcacgcc tgaagaaatc ctgatgaatc 303361 catctaacga atatgttgag aaattcgtcg aagatgttga tttgtctaaa gtcctcacag 303421 caggccacat tatgaaacgc gctgaaacag tgcggattga taaagggcct cgcgtagcat 303481 tgacactgat gaaaaacctt ggaatttctt caatttatgc agtggataaa caaaagaaat 303541 tattaggtgt tatctatgcg tctgatgcga aaaaagcggc tgagtctgat ttgtcacttc 303601 aagacatctt gaatacagaa tttacgactg taccagagaa tacgtatctg actgagattt 303661 ttgacgttgt gtccgatgcg aatattccaa ttgcggttgt ggatgagaag caaagaatga 303721 aaggaattgt cgtaagaggc gcgctgattg gcgcacttgc cggcaataac gagtatatca 303781 atgctgaagg cactaacgaa caaacacaag atccttctgc acaggaggtg aaataagatg 303841 gatagactgc ctagaatacc tttagcagat attattgacc gttttgttga ctggattacg 303901 atgacgtttg gcggattctt cgacggaatc gctaacggat tggccgcttt tgtaaatgga 303961 attgtcaccg gtcttggatt tattccatct attttgttaa cgattatttt cgccgcactt 304021 gcgtggtgga tcagtacaag gggaattgcg ttatttacgt tgattggatt cctcctgatc 304081 gattatttag gatattggga cccaatgctg caaacattgg cgcttgtttt gacatctgtg 304141 attatttcga ttgtggtcgg ggttccgatc ggaatttggg cgtctcagaa agaaacggtt 304201 cgccgtattg taacgccaat tcttgattta atgcagacaa tgcctgcttt cgtatatcta 304261 ttgccggcga ttttcttctt taacatcggt gttgtgccgg gtgttgttgc atctgttatc 304321 ttcgcgatgc cgccgacaat ccgcatgact gttctcggta ttaaacaagt gccggcggat 304381 ttgattgaag cgactgaggc attcggttct acaacagctc agcgtttgtt taaagttcag 304441 ctcccgcttg cgacaaaaac gattttggcc gggatcaacc agagcatcat gcttgcgtta 304501 tcaatggttg ttatcgccgc aatggtcggt gcaccgggac ttggttctga agtatacagt 304561 gccgttacac agctgaaaac cggggtcgga gtagaggccg gtatcgccat cgttatcgtt 304621 gccattaccc tggaccgtat tactcaaaat attaaagtga agaagaaaag cagggggaat 304681 gcctgatgct taaaaaaatc ataggcatcg gcgtttccgc catgctggcg ctctcacttg 304741 cggcttgcgg ttcagaaaac gatgaaaatg catccgcagc agaacaagtg aataagacca 304801 tcatcgggat tgaccccggt tcagggatta tgtccctgac tgacaaagcg atgaaggatt 304861 atgacctgaa tgactggaca ttgatttcag cgtcaagtgc tgcgatgacc gctacgctta 304921 aaaagtcata cgaccgtaag aaaccgatta tcattacagg atggacaccg cactggatgt 304981 tctccagata taagctgaaa tatctcgatg atccgaaaca atcttatggc agcgcagagg 305041 aaatccatac gatcacacgc aaaggcttca gcaaagagca gccgaatgcc gcaaagcttc 305101 tgagccagtt taaatggacg caggacgaaa tgggcgaaat catgatcaag gtggaagaag 305161 gcgagaaacc tgccaaagtt gctgctgagt acgtcaataa acacaaggat cagattgccg 305221 aatggacaaa aggcgttcaa aaggtgaagg gagacaaaat caaccttgcc tatgtggcgt 305281 gggacagtga gattgcaagt acaaacgtca taggcaaagt cttagaagac ttgggctatg 305341 aggtaacact tactcaggta gaggctgggc cgatgtggac tgcaattgcg acgggaagtg 305401 cggatgcatc cctttccgca tggctgccga atacccataa agcatacgcc gctaaatata 305461 aaggcaaata tgatgatatt ggcaccagta tgactggtgt gaagatgggg cttgttgttc 305521 ctcaatatat gaaaaatgtc aactcaattg aagatttgaa gaagtaatca aaaaagcagc 305581 ctgtgtcagg ctgctttttt tgcgttaaga agcgttagcg gcagcaagtg attccgcctt 305641 ctgaaatgtt ttgagcacgg cgttcgccaa aatatgaatg ccggtaaaca tcgcatttct 305701 gtcaaaggtc atgtgcggat gatggagccc cggctggagc ccgcagccta gtccgagcat 305761 cgttgttttc agattcggca ccttcacggc gtaaaaatgg aaatcctcgc cgccggtggt 305821 gacaagcggg tcatcaagcc gctcagcccc gatgatttcc gtaatggctt ctgccatgat 305881 cgcttcagct tctttatttt gtgttgccgc aggaaggctg tgttctttgt gcagctcgat 305941 ctttgcgcca aatgcagcgg cggccgcttc acaggctctt tctgtttcgg cgattaatgc 306001 ctccatggct tcattggtct gtgcgcgcaa atcaaggctg aacgatgctt ttcctggaat 306061 gatgttagag ctttcaccgc cggcttgcag ttttgtcatt ttgacggtat gcgggatttg 306121 cgggtcaata tgaatgagtc cgagcttgtg tacaagaaat gccgcaattt caatgctgtt 306181 tttcccgagg tgcggacggg cgccatgagc ctcttccccg atgatcgttc cctcaatgtg 306241 ctggcttgat ccgtgcagaa tagaaggagc gcagcggccg ttctgtgttt cctggatcgg 306301 acggacgtga acgccataca aatagtcgat atcatcaagc acgccttctt ctatcatttt 306361 caaggcgccg ccgccttttt cttctgccgg ctgaaagata aaacggattg tgcccttcgg 306421 aagctcaggt tgttttttta gcagcattaa cgtgcccaat gccattgtca tatgtgaatc 306481 gtgtccgcag gaatggttgg cgcgaaatgt gccgttaacc tcctgccaca gcgcgtcaat 306541 atcagcgcgt accgctacaa caggtgagcc tgagccgatt tcgccgacaa ccccggtgca 306601 gtctgaaaac gtgcgcgtcc ggcaccctaa atcctcaagc ttttgtttca aaaatgaagt 306661 tgtctcatat tccttccagc tgacttcagg gttcgcgtgc agatgctcga agatgtccat 306721 aatggtttgt ttcatttctt ctgaaagctt ttgcatggta agaaatacct ccttctatca 306781 gaatgaattt ttaccttctt tactttattt atattgaaac aggaagatag gctgtatata 306841 atatagcaca tattgctact attcagaata attaatattt tcaaacagag gggatggatc 306901 gaaatatgag tatgccagca gccgaaacac agcctaagaa aaaacgtatg acatttaaaa 306961 tgcctgacgc ctatgtcctc ttatttatga ttgctttcat ttgcgcaatc gcttcatata 307021 ttgtgccggc aggtgaattt gaccgcgtga caaaggggga tgtcacgacc gctgttccgg 307081 gaagctatca ttcaattgaa cagtctccgg tcagattgat cagctttttt acttctctac 307141 aggatggaat ggttggatca gcacccatca tctttctgat tttattcaca ggcggcacca 307201 ttgctattct agaaaaaacg ggtgccatca atggcctgat ttacaatgtc atcagcaaat 307261 tccgcacaaa gcaattatta tttatttgta ttgtcggcgc attgttctcc attctcggaa 307321 caaccgggat tgtcgtgaat tcagttatcg gttttatccc catcggcctc attgtggcac 307381 gatccttaaa atgggacgca gtcgcgggag ccgctgttat atacatcggc tgctacgctg 307441 gatttaactc caccatatta tcaccgtcac cgctcggttt atcacaatca atcgcggagc 307501 tccctctttt ctcaggaatc ggcctgcgag ttgtgatata catatgcttt ttgctgtctt 307561 ctattattta tatctatttg tatacgagaa aattaaaaaa atcaaaagat gccagtgtgt 307621 taggaacaga ttggttccct gcggcaggaa tgggcgaagc cggtaaagaa gaagatcagt 307681 cagtgccgtt taccgttcgc cataagctga ttttggctgt ggcgggactc tcacttgtcg 307741 gatttttata cggcgctttg aagcttggct ggtcagattc ccaaatggct gcgacattta 307801 tttttatttc tgtccttgcc ggtttaatag gcgggcttgc ggcgaacgat attgccaaaa 307861 ccttcattac gggctgccaa agtcttgtat acggggcgct gattgtcggg atggcacgaa 307921 gcatttccgt tatccttgaa aatggaaagc ttctcgatac tgtcgtcaat gctttggctt 307981 cacttttgga tggattcagc ccgattgctg gggcaatcgg catgtatatc gccagtgcgc 308041 tgcttcattt tctcatctct tcaggttctg gcgaagccgt tgtatttatt ccaatcctgg 308101 cgccgctcgc tgatttgatg ggaatcacga gacaggttgc ggttgaagcg gttatgcttg 308161 gagaaggggt cgtcaactgt gtgaacccga catccggcgt tctcatggcg gtgcttgccg 308221 ccagcggtat tccgtatgtc aagtggctgc ggtttatggt gccgcttgct ctgatttggt 308281 tcttgatcgg gcttgtcttt atcgtgatcg gagtcatgat caattggggg ccgttttaac 308341 gattgctgcc cgccggcttg tacggcgggc ttttgagtta ttcattgcag aagcgcaggc 308401 tgttattgta acatgtaagc cataagccat tcgtaaaagt gcgggaggaa ggtcatgaat 308461 aatctgcgta atagactttc aggcgtgaat gggaaaaata agagagtaaa agaaaaagaa 308521 caaaaaatct ggtcggagat tgggatgata gcgggagcat ttgcgctgct tgatgtgatc 308581 atccgcggca ttatgtttga atttccgttt aaagaatggg ctgcaagcct tgtgtttttg 308641 ttcatcatta tcttatatta ctgcatcagg gctgcggcat ccggaatgct catgccgaga 308701 atagacacca aagaagaact gcaaaaacgg gtgaagcagc agcgaataga atcaattgcg 308761 gtcgcctttg cggtagtggt gcttacgatg tacgacaggg ggattcccca tacattcttc 308821 gcttggctga aaatgattct tctttttatc gtctgcggcg gcgttctgtt tctgcttcgg 308881 tatgtgattg tgaagctggc ttacagaaga gcggtaaaag aagaaataaa aaagaaatca 308941 tcttttttgt ttggaaagcg agggaagcgt tcacagtttc gggcagcttt ttttatagga 309001 acattgattt gtattcactc tgccaagttg ttttgataga gtgattgtga taattttaaa 309061 tgtaagcgtt aacaaaattc tccagtcttc acatcggttt gaaaggagga agcggaagaa 309121 tgaagtaaga gggatttttg actccgaagt aagtcttcaa aaaatcaaat aaggagtgtc 309181 aagaatgttt gcaaaacgat tcaaaacctc tttactgccg ttattcgctg gatttttatt 309241 gctgtttcat ttggttctgg caggaccggc ggctgcgagt gctgaaacgg cgaacaaatc 309301 gaatgagctt acagcaccgt cgatcaaaag cggaaccatt cttcatgcat ggaattggtc 309361 gttcaatacg ttaaaacaca atatgaagga tattcatgat gcaggatata cagccattca 309421 gacatctccg attaaccaag taaaggaagg gaatcaagga gataaaagca tgtcgaactg 309481 gtactggctg tatcagccga catcgtatca aattggcaac cgttacttag gtactgaaca 309541 agaatttaaa gaaatgtgtg cagccgctga agaatatggc ataaaggtca ttgttgacgc 309601 ggtcatcaat cataccacca gtgattatgc cgcgatttcc aatgaggtta agagtattcc 309661 aaactggaca catggaaaca cacaaattaa aaactggtct gatcgatggg atgtcacgca 309721 gaattcattg ctcgggctgt atgactggaa tacacaaaat acacaagtac agtcctatct 309781 gaaacggttc ttagacaggg cattgaatga cggggcagac ggttttcgat ttgatgccgc 309841 caaacatata gagcttccag atgatggcag ttacggcagt caattttggc cgaatatcac 309901 aaatacatct gcagagttcc aatacggaga aatcctgcag gatagtgcct ccagagatgc 309961 tgcatatgcg aattatatgg atgtgacagc gtctaactat gggcattcca taaggtccgc 310021 tttaaagaat cgtaatctgg gcgtgtcgaa tatctcccac tatgcatctg atgtgtctgc 310081 ggacaagcta gtgacatggg tagagtcgca tgatacgtat gccaatgatg atgaagagtc 310141 gacatggatg agcgatgatg atatccgttt aggctgggcg gtgatagctt ctcgttcagg 310201 cagtacgcct cttttctttt ccagacctga gggaggcgga aatggtgtga ggttcccggg 310261 gaaaagccaa ataggcgatc gcgggagtgc tttatttgaa gatcaggcta tcactgcggt 310321 caatagattt cacaatgtga tggctggaca gcctgaggaa ctctcgaacc cgaatggaaa 310381 caaccagata tttatgaatc agcgcggctc acatggcgtt gtgctggcaa atgcaggttc 310441 atcctctgtc tctatcaata cggcaacaaa attgcctgat ggcaggtatg acaataaagc 310501 tggagcgggt tcatttcaag tgaacgatgg taaactgaca ggcacgatca atgccaggtc 310561 tgtagctgtg ctttatcctg atgatattgc aaaagcgcct catgttttcc ttgagaatta 310621 caaaacaggt gtaacacatt ctttcaatga tcaactgacg attaccttgc gtgcagatgc 310681 gaatacaaca aaagccgttt atcaaatcaa taatggacca gagacggcgt ttaaggatgg 310741 agatcaattc acaatcggaa aaggagatcc atttggcaaa acatacacca tcatgttaaa 310801 aggaacgaac agtgatggtg taacgaggac cgagaaatac agttttgtta aaagagatcc 310861 agcgtcggcc aaaaccatcg gctatcaaaa tccgaatcat tggagccagg taaatgctta 310921 tatctataaa catgatggga gccgagtaat tgaattgacc ggatcttggc ctggaaaacc 310981 aatgactaaa aatgcagacg gaatttacac gctgacgctg cctgcggaca cggatacaac 311041 caacgcaaaa gtgattttta ataatggcag cgcccaagtg cccggtcaga atcagcctgg 311101 ctttgattac gtgctaaatg gtttatataa tgactcgggc ttaagcggtt ctcttcccca 311161 ttgagggcaa ggctagacgg gacttaccga aagaaaccat caatgatggt ttcttttttg 311221 ttcataaatc agacaaaact tttctcttgc aaaagtttgt gaagtgttgc acaatataaa 311281 tgtgaaatac ttcacaaaca aaaagacatc aaagagaaac ataccctgga aggatgatta 311341 atgatgaaca aacatgtaaa taaagtagct ttaatcggag cgggttttgt tggaagcagt 311401 tatgcatttg cgttaattaa ccaaggaatc acagatgagc ttgtggtcat tgatgtaaat 311461 aaagaaaaag caatgggcga tgtgatggat ttaaaccacg gaaaggcgtt tgcgccacaa 311521 ccggtcaaaa catcttacgg aacatatgaa gactgcaagg atgctgatat tgtctgcatt 311581 tgcgccggag caaaccaaaa acctggtgag acacgccttg aattagtaga aaagaacttg 311641 aagattttca aaggcatcgt tagtgaagtc atggcgagcg gatttgacgg cattttctta 311701 gtcgcgacaa atccggttga tatcctgact tacgcaacat ggaaattcag cggcctgcca 311761 aaagagcggg tgattggaag cggcacaaca cttgattctg cgagattccg tttcatgctg 311821 agcgaatact ttggcgcagc gcctcaaaac gtacacgcgc atattatcgg agagcacggc 311881 gacacagagc ttcctgtttg gagccacgcg aatgtcggcg gtgtgccggt cagtgaactc 311941 gttgagaaaa acgatgcgta caaacaagag gagctggacc aaattgtaga tgatgtgaaa 312001 aacgcagctt accatatcat tgagaaaaaa ggcgcgactt attatggggt tgcgatgagt 312061 cttgctcgca ttacaaaagc cattcttcat aatgaaaaca gcatattaac tgtcagcaca 312121 tatttggacg ggcaatacgg tgcagatgac gtgtacatcg gtgtgccggc tgtcgtgaat 312181 cgcggaggga tcgcaggtat cactgagctg aacttaaatg agaaagaaaa agaacagttc 312241 cttcacagcg ccggcgtcct taaaaacatt ttaaaacctc attttgcaga acaaaaagtc 312301 aactaaccgc aactttagag taaagggctg attgtcaatg tgggagcagt tgtatgatcc 312361 gtttggaaac gagtatgtga gcgcacttgt ggcgctcact ccgattctct tttttctttt 312421 ggctttaact gttttgaaaa tgaaaggcat tcttgcggca tttcttaccc tagccgtcag 312481 tttcttcgtc tccgtttggg catttcatat gccggttgaa aaagcgattt cttctgtttt 312541 gttaggaatc gggagcgggc tgtggcccat tggctacatc gtcctgatgg cggtgtggct 312601 gtataaaatc gccgtgaaaa ccgggaaatt taccattatt cggtccagca ttgccggcat 312661 ttcgcctgac caacgattac agctattatt aattggtttt tgttttaacg cgtttttaga 312721 aggcgcggcc ggttttggtg ttccgattgc gattagtgcg gcgctgctcg tcgaacttgg 312781 ttttaaaccg ttaaaagcgg cggcgctctg cttgattgca aacgctgcct ccggagcctt 312841 tggggcgatt gggattcctg tcatcacagg ggcgcagatt ggtgatttgt ctgctcttga 312901 gctgtctcgg acattaatgt ggacactgcc gatgatctca tttttaatac cattcctgct 312961 tgtattctta ttagaccgaa tgaaaggaat caaacagaca tggcccgctc ttctggttgt 313021 gagcggtggg tatacagcgg ttcagacact gacaatggcg gtgctcgggc cggaattagc 313081 aaacattttg gcggccttat tcagcatggg cgggcttgcc ctcttcctcc gcaaatggca 313141 gccgaaagag atttaccgcg aggaaggggc cggcgatgct ggtgagaaaa aggcataccg 313201 tgccgctgac attgcgaaag cgtggtctcc tttctacatt ttaactgcgg cgatcaccat 313261 ctggagcctt cctgccttca aagcgctttt ccaagaaggc gggctgttat atcaatcaac 313321 gctcctgttc aaaatgcctt ttctgcatca gcaaattatg aaaatgccgc cgattgcgcc 313381 atctgccatg ccgttagatg cagtctttaa agttgatctg ctgtcagcga ctggtacagc 313441 gattttagcg gcggtcatcg tgacagggct gttcagcaaa aagttctcct ctcgggatgc 313501 ctttgcttcc ttgaaggaga cgggaaaaga gctgtgggtg ccgattatga cgatctgctt 313561 cgtgatgggg tttgccaatc tggccaactt cgcagggctc agctcttcaa ttgggttagc 313621 attggcgaaa acaggagacc tgttcccgtt tgtcagtcct gttctcggct ggattggcgt 313681 gttcatcacc ggttctgttg tcagcaataa tgctttgttc ggccatttgc aggttgtcac 313741 gggagcgcag atcggtgcgg gttcagattt gctgttagcc gcaaatacgg cgggcggtgt 313801 catggcgaaa cttgtttctc ctcaatctat cgccatcgct gccgcagcgg tcggccaaac 313861 aggcaaggaa tctaaactgt ttaaaaggac agtggcgtac agcctgattc tgttattgat 313921 catttgtata tggacgttta ttcttgcaag attaggagtg taatagaaaa aagcagtaca 313981 tgcccagcat gtactgcttt ttttatgtta atttgctttc tttgtcattt cggctgttgt 314041 tttcactctg gcttttccca taaataaaat ggtaaccgcc gcgaggacaa ttggaatcaa 314101 agcgagcaaa aagacatacg tgatacttga tgacatcgcg tcaataatgc gattcaggat 314161 cgcatcagga atctgggaac gtgttcccgc ttggaatatc tcctgcgggt cgccaatatt 314221 ttgcgcagcg cctgatcccg ctgagccttt cataccgctg aaggcgtcat tcagcttgtt 314281 tgtgaatacg tttgtttgca ccgttccgaa aatggtgaca cctaaggtca tgccaaatga 314341 tcgcaaaaat gaatttgtag agtttgccgt tccccgaaag cgaggttcaa gatcattcat 314401 cgatgccgcc ggcagcaggg agaagttaaa gcctacacca aagcctgaaa tcatcataaa 314461 gactgtcagc catacccgtg ctgtgtcagg cgtcatattg gaaagaagca gcatgccgat 314521 aaagaaagct ataacagata tcagcatcaa attgcggaag cttgccttcg tttggaagat 314581 cccgccgatc atgcttccga tgactgatcc aatcatcatc ggcgtcagaa tgaagcccgc 314641 gcttgtcgcc gagctgccgt agaccgcctg aacgaaaatc ggaataaata ccgctaaaat 314701 aataaatgtt ccgccataca ggaaagcgag aatctgtgct gtggcaaaca agcggttctt 314761 aaacatccag aaagaaataa tcggctcttc tgcttttctc tccacaataa aaaaggcaat 314821 gaagaaaacg gcgaatacaa taaacagccc gatgatctga atggagttcc aatcgtatgt 314881 tttgccgcca agctcaaggg cgaacatcag gcatacaatg gatacgacta aggtaatcgc 314941 gccgccccag tctattttct gctttctgtg ctccagagat tctttgtagt agcgaataat 315001 gaaaaacaat gacaatgcgc cgatcggcac attgatgtaa aacacccagt gccagctgat 315061 cgaatctgta atgatcgcgc ctaagagcgg accaagaaca ctggataatc caaatacagc 315121 accgaacatg ccggacattt ttccgcgttt ttccggcgga aacaaatcaa agataatggt 315181 aaaggcaatc ggcaggagcg cgccgcctcc gatcccttga atggcccgga agatgatcag 315241 ctgattcatc gtctgggcaa tcccgcataa agcagaaccg attaagaaaa aaataagtcc 315301 aaacaggaaa aaacgttttc ggccgtacat atcggaaagc ttgccgtaaa tcggcatgcc 315361 agccataacc gccaccatat aggatgccgt cacccaggca aatttatcga agcttccaag 315421 atcggctacg atattgccca tcgcggtggc aacaatcgta ttgtccattg cagacatcaa 315481 gatgcccagc aggagaccga ggaccacaaa tttggtggaa gcctgttttg ctgttgttgt 315541 gtccatttgt tctacctcct cttacttttc tatgtaagtt ctgatatcat gataatagtt 315601 tgattgttga atatctcgat tatcaagata aactcgattt tatagggagg actgtcagtt 315661 gtcaacaaga aattccagaa gtgagttgga aaagactgct gttcagcttt ttcgaaaact 315721 gggcacaaga acggttctgt ttcatcaggc agccgctcaa gctctcggtc tgtttcccac 315781 cgatttgaaa tcagctgaca ttttaaatga agcagggccg atgacggccg gagagctggg 315841 gaaaaaaacc ggcctcagca cgggttccgt cacggcgctt gttgaccggc tggaaaaagc 315901 ggggtatgtg gctcgtgaaa aggacccgaa cgatcgcagg agagtcgtaa tcgtcccttt 315961 gactgcttcg aaaaaacata taaaggattt gttccgtcct ctgtctgagt caacgatgga 316021 tttgtgccgc gaatatacgg aagaggagct ggaactcatt ttcagttttg taggcaaagc 316081 tgccgatatt atggaggaag agcttgaacg tctgaaacag taagtgaatt tgtgcatagc 316141 ttggcccgtt cccgaataaa ttgtacaagt tacataagag aagggagtac gggccggtga 316201 acattttttt gagctatatt gtgctgggac tgtccttgtc tgcgcctgtg gggccagtga 316261 atgcggcgca aatagacaaa ggaattaaaa acggtttttg gcatgcatgg attttcggtt 316321 taggcgccat gacagcggat gggctgtaca tgctttttat ctatttcggg ctgtcgcagt 316381 tcttgaccgc tccatttgtg aaaacgtttt tgtggctgtt cggctttttt gtcctgacct 316441 ataccggaat tgaaacgctg aaaaacgtca gagaaccgat ggatgtgcga agctcgcggg 316501 ggaaaccgtc atacaggaaa acattcgcat cgggttttct catttcattg tcaaacccat 316561 tgagcatcct tttttggctt ggaatttacg gaagcattct tgcgaaaaca gcagaggcct 316621 acaatatgaa tcagcttcta atctatagct ccggcatcat gatcggcatt ttaatctggg 316681 atttctgcat ggctatcaca gccagtacgt tcagaaacct gcttcatgaa aagctattga 316741 gaggattgac cggaatcgcc ggtgtatccc tccttgtgtt tggcttttac tttggttatc 316801 agggcatcaa acagttattg ggctgattca tgaaggacag tcacctgccg cttccagttt 316861 taatatagta tccagatgat actggaggtg gatcaatggt gaatgggatt tacaccaaaa 316921 gttttctgga acgtattcag gaagagcttc ctgaatggca aagaatcgct tttgagctgc 316981 tggcagaaac tctgggggac gacgcggata catttccgtg cattcccgga cgccaggcgt 317041 ttctgactga tcagcttcgg attgcttttg ccggagatcc gcgggaaaac cgcacagcgg 317101 aggaactggc tccgttgctt gcggagtacg gcaagatatc gcgggacacg ggaaaatacg 317161 catccctcgt tgtgttgttt gatacaccgg aagatttggc ggagcattat tcgattgaag 317221 cgtatgaaga gctgttttgg cgctttttaa atagactgag tcatcaagac gaaaaagaat 317281 ggccggaaga cattccggcc gatcctgagc attataaatg ggagttttgt tttgacggcg 317341 agccgtattt cattctgtgc gctacaccgg ggcacgaggc aagaagaagc cggagctttc 317401 ctttttttat ggtcacgttt cagccaaggt gggtgtttga tgacctaaat ggatcaactg 317461 catttggccg taacatgagc aggctgatcc gatctcgttt agaggcctat gatcaggctc 317521 cgattcaccc gcaattaggc tggtacggag gaaaagataa tcgtgaatgg aagcagtatt 317581 tcctccgtga tgacgaaaaa caggtatcga agtgcccgtt ttcttattta aagaacatgt 317641 tcaacaaaat gaaataaatc aaggactggc agggcgatct ttatgaccct gctttttttg 317701 atagatcatg gtaacgatgg cgataatcac gagaaaacct atgctgacga aaaaaccggg 317761 ccggcttgat ttttcaaaca atgtaccgga cacagctgca gcaatcagaa ccatcgctaa 317821 ataaatttgc gtttttccca tgccctcggg atcagtcagc tttttgctgg agaacaggat 317881 aaacagccaa gtgtataaaa gcataagccc cgcagctgtt gtcatatgct cataaatgtt 317941 tttaggcagc actaacgaca aaataatgga gaggacaagc cccgcaaacg tcagcccaag 318001 tgccggccag catatttttt tgccttcctt tagagtaaag catttcggcg cgtcgccgtc 318061 atcagccatt gtacaaagca atgtcgtaac cgcaaatagc gaagcgacaa gggtcgagaa 318121 ccctgcgatg atgaaaatcc cgttaaatat atcaaggatg atctcaaggt tatatccttt 318181 taatgacgta atgaacggac tgtcctgttc agtaaacgtg tgtaacggaa ccaaaagcag 318241 agcaagcccg attgaaatga tataaataat cgccagcgtc gccagcatca gtttccctga 318301 tttagacgct tcctcaggtt tttttaagtg aaccgccatc agccccatga cctcaattcc 318361 gccaaaagcg taaaacgcgt agattaaacc tgtccacagc cccatggcgc cgtatgggaa 318421 aaactcactc gtcttatttg gaacatgtat gccatgattt ccgccggaca ggataccgca 318481 taaagccagg atggcaatga caataaacat aaaaatagca gctgttttaa tgactgccag 318541 cacgttttct gttttttcaa agacggacag gccggtgaaa ataataagga gcccaagtac 318601 tgcgtagatt gaggcaaaca cccatagcgg cacttgagga aaccaatgct tcgtaaagag 318661 cgaaatggct gtcagctggc ttccggtaat cagcatttct gatgtccagt acacccagcc 318721 gttgctgaag cctgcccatt tgccgaatgc ttttcgggca tacgcacaaa acgagccctt 318781 ttccggctgc ttcgccgata gcttggcgag ctgttcaaag acaaaatacg taccgatccc 318841 tgcgatcaga aatgaaagga gaacggaaaa accgcttttt acaattgcga tgctggaacc 318901 gagaaagaag cctgttccaa tcgtgcagcc gactccgatc agtgacagct gccaccaagc 318961 cagattccct tttggctggt ctttttttgt ttggctcatt atttattcaa ccccttttat 319021 ctaaggttag attgtgatct gtccaaagct tatatacatc ggatttttgc ctctttttac 319081 atggagaagg aagcagacgc tcatactaat gaaaaaagga gcaaaccaat gacacagcaa 319141 tatattgtgg agccgaaaaa agggcttggg ctgaagctga aaaaggggca gattttaaag 319201 gtggttgatg tagaagggca gcaggtggct gattttgtcg cataccatgc caaggatttt 319261 tatgaacacc ttgatcaggg agcgacgata gacgccaatc actccattca tgtgaaggtc 319321 aacgaccatc tctactccaa cctgtataag ccgatgttaa ccctgattga agatacggtc 319381 ggcaagcatg atctgctgtt gcccgcctgc cgtcctgata tgaacaggct cttatatggg 319441 aagcaaaagg atgagtttca ggatacgtgc tatgacaata tgaaccgtgc gcttgagcag 319501 tttggcgtac cgaagcccca catgcattac ccatttgcga tttttatgaa tactgtcctt 319561 gatgagaaag ggaatctgtc tgtggaaacg ccgctttcga atgccggaga ttatgtaagg 319621 ctcagggcgg agatggattt aattgtcgcg ttttcttcct gcccgattga aaaagggaaa 319681 tgcaatggcg acagtgtgac atccatacgg gttgaagtca gctgatctct cttgttcaca 319741 gtgaatgaag acctgtgcta tatttaatag ggatacataa cagtcatgat tcattttcat 319801 tgatttaggg aaatgatcag taataaggga aaatgtacag gaggaatgat tgggatgagc 319861 atgcaggaaa agattatgcg tgagttacat gtgaagccct caattgatcc aaagcaagaa 319921 attgaggacc gagtcaattt tttaaaacaa tatgtaaaga aaaccggtgc taaaggcttt 319981 gtattgggaa tcagcggggg ccaggattca acacttgcgg gaagactcgc tcagcttgcg 320041 gtggagagca ttcgcgagga gggcggagac gctcaattta tcgcggtccg tcttccgcat 320101 ggcacacagc aggatgaaga cgatgcccag cttgctttga agtttattaa gccggataaa 320161 tcatggaagt ttgatattaa atcgacagtc agcgcttttt ctgatcagta tcagcaggaa 320221 acaggcgatc agctgacgga ctttaataaa ggaaacgtaa aagcaagaac aagaatgatc 320281 gcgcaatacg cgatcggcgg ccaggaaggt cttcttgtgt taggaacaga ccatgctgct 320341 gaagcagtga ctggtttctt tacgaagtac ggtgacggcg gagcagacct cctgccgctg 320401 acaggcttga cgaagcgcca gggaagaacc ttgctgaaag agctgggtgc accggaacgc 320461 ttatacttaa aagaaccgac tgccgatctg ctcgacgaaa aaccgcagca gtcggatgaa 320521 acagagcttg gcatttccta cgacgagatt gacgattatc tcgaaggaaa agaagtatca 320581 gcgaaagtat cagaagcgct ggaaaaacgc tacagcatga ctgaacataa acgccaggtt 320641 ccggcgtcta tgtttgatga ctggtggaaa taagttgaag aaagcccgct ctcggagcgg 320701 gcttttgtcg tgtacagaag ctttatttga tgcggatatg attcagcttt accattaatc 320761 tgtcggcgaa ccttcggagg ctgcctcttg tatcaggatc taatgggagt tcggctctcg 320821 cggcaatgtt ctctgccaca tcctgaatcg acaggttgtc tgtttgaatg tggtcctcaa 320881 aaatgggtga tgataatcct tcaacacagc ggtcaatttg tttggcggcc catgagtttt 320941 ttccttctgc tctggtgcgc agccttttta acaaggtttc ctttgaagcc attagtgtaa 321001 agtggtgaac gatcctgcct tcctgtctga gcctgccgat gatctcattg aagtattcag 321061 ggtgtacaat cgtcataggc acaataagga tgccgcggta tgtatctgtc agagaagcta 321121 gcaaactgta attgaacgcc cgccataaag gatagctttg aaaatcgtcc tttgcgatct 321181 cctgcggcac catggagcgc agcgcaaaac ccattttctc gggatcatac acgtaagatg 321241 ggttcagcct tctgtgcagt tcgaaggctg tttgtgtttt tcccgaaccg aatgccccgt 321301 ttatccaaat gatcatcgcc atttctccct tcctatttat catacagaaa aagacccttc 321361 catcgaagag tcagctggaa aaacaataaa ggcggaaggt tttaacgctt ttttgcgtcg 321421 aagtattaaa atacctgcag aaatgttgta caatgaatgt cattcaggca aaaatggcta 321481 caacaaagcg cactataagc ttgaccggta aagccggtat ctatataaat attcgctaaa 321541 taagcatata atgaatatat aatttcattc cttaggagga tttcgccgaa gatgaacgct 321601 aaacgagcca tcccagtaag agaaagaaat atcgtcctga tcggattcat gggtgtagga 321661 aaaacaacaa tcggccaatt ggtcgctaaa aaattatata gagattttat tgatattgac 321721 cagcagatcg aaaaggattt caatatgtca attcctgaga tatttgagaa aaagggagaa 321781 gactttttcc ggaaaacgga gaaggaatat attttagaca tctgccatca taaacgattc 321841 aaaatcgtat ctctgggcgg gggatctttt aaacaagaag aaatcagaaa ttgctgtctg 321901 gaaaactgtc tcgtgcttca tctggacctg tcatgggaga actggaagca gcgcgcggat 321961 ttattgatcg aaagccgccc tgtactgcat aaccgttcaa tggatgaaat ggaacagctg 322021 tttaacgaaa gaaaagtcat ttatgacaag cacaattcaa aagtggcaac agacaacctt 322081 tccccggaag aggttgccga ttacattgtt gagacattaa aaattggctg ggatctttat 322141 cagccgatgt aaaaagccgt gcgcagcgca cggctttttt tatcgtttta tcccttgtat 322201 caaaatcgct tttaaacaaa aggagatggg ctgtccgttt tggttcaatg taatacagaa 322261 cgtgtcgcgt gcttcgtctg atgcgtgatt caagtgggta atgatttgtt tttctcggtc 322321 agcgggggtt ccgcctcgtt tgatccagct atcgtattga atcggcaagt tccacttttg 322381 gatgtcttga taggccagtt gattggcgct gaacatcgcc tgccattctg ataatgagct 322441 ttcacgaaca tgggaagggt ctcgaagccg gttcaaatga ttgacaaact catcaagaac 322501 gggatcttca ggcgcgtaat gatcaactaa gagaaaacgt ccgtcctgtt ttagtacgcg 322561 tgcaacctct ctgacagctt tgcggacatc tgaaaaatgg tgggctgcgt atcggcaggt 322621 gatgatgtca aatgaatcgt cggggaaggg gagtgactct gccgttcctt gctgaaagcg 322681 tacgttttca actccttttt cttgcgcgaa ggaggacgca acctcaacca tctctttcgt 322741 tgcatcaaca ccgatgcact cctgtacata aggagaaaat gccagcgccg tatggccggc 322801 gcccgctcct atatccagca ctcgatgctc tgcccggcat tccgctgttt tgatcatcaa 322861 ccccaaatct tccccctcgg caaatacctt ttcatcccga tacatctcgg cgtttttaga 322921 aaacggtgtt tcatttgtca tttgaaccag ctccttcttt tcgtaaatga tgatatggat 322981 tatgttagca atttctgtta tgattcgtcc aagatataaa aatgatgaaa atgataggtt 323041 caacctatgg aggctgaaat ggatattaaa gtgatggaat atgcagcgga aattgcccgg 323101 cgccaaagct ttacaaaggc ggcggaacat cttcatatcg cacagccgtc tctcagccag 323161 caaatcaaaa agcttgaggc tgagctgggg cttacccttt ttcacagatc ccatggctct 323221 gttacactga cacctcacgg caggcgtttc attgaaaaag ccgaggacat cattcgttcc 323281 agagatgatt tgcttcggga aatgcaggag cgatcacagg gaatcggtca taaattatcc 323341 atcgggattc ctgctgtaac agggagatat ctctttcctc cgctgctgaa gcagtttttg 323401 gcgcgctatc ctcatgtgga ggttcagctt gttgaaaaag atccggtttc attagagaag 323461 atgacggcaa agggagaagt tgacctttct gttttatcct tgcccatcga ggatgaacgg 323521 ctctccatta cacccttgct cacggaaccg gttgttctcg cggtgccgaa ggaaaaacaa 323581 aggtggatgc cgccggaatt ggtcgcgctg attgagaaag cgctggaaga agatgaggga 323641 cgccagccgt gtgtgccgat tgacatggta aggaacgtgc cctttattct gttaaaagaa 323701 ggcttcggct ttcgcaggac agttctcgat ctctgtgcgg aaagcggctt taagccgaat 323761 gctgccttta agacgagcca tattgaaacc gcccaatctc ttgtggctaa cggattaggt 323821 gtgacaatgg caccgaatat ggtcagaagg gataaagatc cgggtgtgat ctatttatcg 323881 attcaatccg cgccatcacg aaccctcgtc tttgtctttt taaagaaccg ctatgtcagt 323941 ctgacggccc aggcctttat ggaactaagc cgggaaagtc ttaaacaaac gtttgatgaa 324001 ggctgtctgg gaaacaaaga tgaaaatatt tagaaaacaa agacgaaacg tggtagtata 324061 ggaatacaaa ctaaatctta taaaacaaag gggaataatc ggaaatgcaa ctattcgatc 324121 tgccgctcga ccaattgcaa acatataagc ctgaaaaaac agcaccgaaa gatttttctg 324181 agttttggaa attgtctttg gaggaacttg caaaagtcca agcagaacct gatttacagc 324241 cggttgacta tcctgctgac ggagtaaaag tgtaccgtct cacatataaa agcttcggaa 324301 acgcccgcat taccggatgg tacgcggtgc ctgacaagga aggcccgcat ccggcgatcg 324361 tgaaatatca tggctacaat gcaagctatg atggtgagat tcatgaaatg gtaaactggg 324421 cactccatgg ctacgccaca ttcggcatgc ttgtccgcgg ccagcagagc agcgaggata 324481 cgagtatttc accgcacggt cacgctttgg gctggatgac gaaaggaatt cttgataaag 324541 atacatacta ttaccgcggt gtttatttgg acgccgtccg cgcgcttgag gtcatcagca 324601 gcttcgacga ggttgacgaa acaaggatcg gtgtgacagg aggaagccaa ggcggaggtt 324661 taaccattgc cgcagcagcg ctgtcagaca ttccaaaagc cgcggttgcc gattatcctt 324721 atttaagcaa cttcgaacgg gccattgatg tggcgcttga acagccgtac cttgaaatca 324781 attccttctt cagaagaaat ggcagcccgg aaacagaagt gcaggcgatg aagacacttt 324841 catatttcga tattatgaat ctcgctgacc gagtgaaggt gcctgtcctg atgtcaatcg 324901 gcctgattga caaggtcacg ccgccgtcca ccgtgtttgc cgcctacaat catttggaaa 324961 caaagaaaga gctgaaggtg taccgctact tcggacatga gtatatccct gcttttcaaa 325021 ctgaaaaact tgctttcttt aagcagcatc ttaaaggctg ataaatgtga aaagccgccg 325081 catatcatca ggcggttttt ttctgcaaac tgccggaatg agaacagact ggagacgaat 325141 agatatgaaa caaagaatca ttgatgaatt aaaacggatc gagcagtcat acggagtcaa 325201 aatcgtgtat gccgtcgagt caggaagccg cgcatgggga tttccctcgc aggatagtga 325261 ttacgacgtc cgctttattt atgttccgaa aaaggagtgg tacttttcaa ttgagcagga 325321 gcgtgatgtc attgaggaac cgattcacga tttgctggat atcagcggct gggagctgag 325381 aaaaacgctt cggcttttca aaaagtcaaa ccctccgcta ctcgaatggc tgtcctcaga 325441 cattgtgtat tatgaagcat ttacgaccgc agagcagtta agaaaactcc gcacggaggc 325501 atttaagcct gaagcaagcg tgtatcacta tatcaatatg gcgagaagga acgtcaagga 325561 ttatctacaa ggacaagagg tcaaaattaa aaagtacttc tacgttcttc ggcctatttt 325621 ggcctgccaa tggattgaaa agcacggaac cataccgcca atggacttta ctgttttgat 325681 gaatgaactt gttgctgaac ccgagctgaa ggctgaaatg gaaaccttgc ttgaacggaa 325741 aagaagaggg gaagagcttg acctcgaagc aagaatcgat gttattcacc aattcattga 325801 aacggaaatc gaaagaatca tggaagcggc aaaagaactg aaggcagaga aaaaagatat 325861 gacatctgaa ttgaaccgtt tgcttttgaa tacggttgaa gaagtgtgga aggatggagg 325921 aagctgatgt tttttgtcgc ttccttttct cctttattcg acagaatccc cccccgactt 325981 tctaactatc tgattgtggc aaacccacaa aaataatcag aatctttgta ttttgagaat 326041 attgtgaacg ctggttttgt ccatttacaa taaactcata caaatacttc ttagattgcg 326101 gggtgttgag gttggaagtg atcacaagag attttttctt atttttatcc aaaagcggct 326161 ttctcaataa aatggcgagg aactggggaa gtcgggtagc agcgggtaaa attatcggcg 326221 ggaatgactt taacagttca atcccgacca ttcgacagct taacagccaa ggcttgtcag 326281 ttactgtcga tcatttaggc gagtttgtga acagcgccga ggtcgcacgg gagcgtacgg 326341 aagagtgcat tcaaaccatt gcgaccatcg cggatcagga gctgaactca cacgtttctt 326401 taaaaatgac gtctttaggt ttggatatag atatggattt ggtgtatgaa aatatgacaa 326461 aaatccttca gacggccgag aaacataaaa tcatggtcac cattgacatg gaggacgaag 326521 tcagatgcca gaaaacgctt gatattttca aagatttcag aaagaaatac gagcatgtga 326581 gcacagtgct gcaagcctat ctgtaccgga cggaaaaaga cattgacgat ttggattctt 326641 taaacccgtt ccttcgcctt gtaaaaggag cttataaaga atcagaaaaa gtagctttcc 326701 cggagaaaag cgatgtcgat gaaaattaca aaaaaatcat ccgaaagcag ctcttaaacg 326761 gtcactatac agcgattgcc acacatgacg acaaaatgat cgactttaca aagcagcttg 326821 ccaaggaaca tggcattgcc aatgacaagt ttgaatttca gatgctgtac ggcatgcggt 326881 cgcaaaccca gctcagcctc gtaaaagaag gttataacat gagagtctac ctgccatacg 326941 gcgaggattg gtacggctac tttatgagac gccttgcaga acgtccgtca aacattgcat 327001 ttgctttcaa aggaatgaca aagaagtaaa aaaggagaga ttatcatgac aacaccttac 327061 aaacacgagc cattcacaaa tttccaagat caaaacaacg tggaagcgtt taaaaaagcg 327121 cttgcgacag taagcgaata tttaggaaaa gactatccgc ttgtcattaa cggcgagaga 327181 gtggaaacgg aagcgaaaat cgtttcaatc aacccagctg ataaagaaga agtcgtcggc 327241 cgagtgtcaa aagcgtctca agagcacgct gagcaagcga ttcaagcggc tgcaaaagca 327301 tttgaagagt ggagatacac gtctcctgaa gagagagcgg ctgtcctgtt ccgcgctgct 327361 gccaaagtcc gcagaagaaa acatgaattc tcagctttgc ttgtgaaaga agcaggaaag 327421 ccttggaacg aggcggatgc cgatacggct gaagcgattg acttcatgga gtattatgca 327481 cgccaaatga tcgaactggc aaaaggcaaa ccggtcaaca gccgtgaagg cgagaaaaac 327541 caatatgtat acacgccgac tggagtgaca gtcgttatcc cgccttggaa cttcttgttt 327601 gcgatcatgg caggcacaac agtggcgccg atcgttactg gaaacacagt ggttctgaaa 327661 cctgcgagtg ctacacctgt tattgcagca aaatttgttg aggtgcttga agagtccgga 327721 ttgccaaaag gcgtagtcaa ctttgttccg ggaagcggag cggaagtagg cgactatctt 327781 gttgaccatc cgaaaacaag ccttatcaca tttacgggat caagagaagt tggtacgaga 327841 attttcgaac gcgcggcgaa ggttcagccg ggccagcagc atttaaagcg tgtcatcgct 327901 gaaatgggcg gtaaagatac ggttgttgtt gatgaggatg cggacattga attagcggct 327961 caatcgatct ttacttcagc attcggcttt gcgggacaaa aatgctctgc aggttcacgt 328021 gcagtagttc atgaaaaagt gtatgatcaa gtattagagc gtgtcattga aattacggaa 328081 tcaaaagtaa cagctaaacc tgacagtgca gatgtttata tgggacctgt cattgaccaa 328141 ggttcttatg ataaaattat gagctatatt gagatcggaa aacaggaagg gcgtttagta 328201 agcggcggta ctggtgatga ttcgaaagga tacttcatca aaccgacgat cttcgctgac 328261 cttgatccga aagcaagact catgcaggaa gaaattttcg gacctgtcgt tgcattttgt 328321 aaagtgtcag actttgatga agctttagaa gtggcaaaca atactgaata tggtttgaca 328381 ggcgcggtta tcacaaacaa ccgcaagcac atcgagcgtg cgaaacagga attccatgtc 328441 ggaaacctat acttcaaccg caactgtaca ggtgctatcg tcggctacca tccgtttggc 328501 ggcttcaaaa tgtcgggaac ggattcaaaa gcaggcgggc cggattactt ggctctgcat 328561 atgcaagcaa aaacaatcag tgaaatgttc taagcgggac taaatgggca tcctccctgc 328621 gggggtgtcc atttcatcca tatactataa aaaagaggag gaagtgccat agaaaacaca 328681 cagctgatta tttcgatttg tatttatatg gcgggaatgc tgctaatcgg ctactttgct 328741 tacaagcgta cgtcgaatct gacggattat atgctgggag gacgctcttt gggtccggca 328801 gtaaccgctc tcagtgccgg cgctgccgat atgagcggct ggctgctaat ggggcttccg 328861 ggcgccatgt tttctactgg tctgagcggc gcttggatcg tcatcggact ttgccttgga 328921 gcgtgggcga actggcttta cgtcgcacca cggctgagaa cctatactga aaaagcgggg 328981 aattctatta caattcccgg attcctggaa aatcgcttcg gagatcaaac aaagcttctc 329041 agactgtttt cgggaattgt cattttagtc tttttcacgt tttatgtatc gtccggaatg 329101 gtgtccggcg gcgtcttatt caacagcatc ttggggatgg attatcacac cggcctgtgg 329161 attgtgacgg gtgttgttgt ggcatatacc ctgtttggcg gctttttggc agtcagctgg 329221 acagattttg ttcaggggat tattatgttt gccgcactca ttcttgtgcc gatcgttacg 329281 tttttccaca cgggaggagc aggtgataca gttgctgaaa tccgctctgt agatcctgat 329341 atgtttaata ttttcaaagg aacgagcgtc cttggcatta tttctttgtt tgcctggggg 329401 ctgggatact ttggccagcc gcatattatt gtgcgtttta tggcgataac gtctgtcaaa 329461 gagatcaaaa gagcgcgcag aattgggatg ggctggatga ttttgtctgc agtaggcgca 329521 gtgctgaccg gtttgggcgg aatcgcttat taccatcagc gcggcatgac actgaaggac 329581 ccagagacga tttttattca attagggaat atcttgttcc atccgattat cacgggtttt 329641 ctgatttcag cgattttggc cgcgattatg agtacaattt cttcccagct gcttgtgaca 329701 tcaagctctc tggtagaaga tttgtataag tcgatgttca gacgctcagc ttcagataaa 329761 gaactggtgt ttttaggccg actggctgtt ctggctgttt caattgtcgc gttggttctg 329821 gcttgggaga aaaataacac catccttgga ttggtcagct acgcgtgggc gggcttcggt 329881 gcatcattcg ggccagttgt actgctcagt ctgttttgga aacgaatgac caaatggggg 329941 gcactcgccg gcatgattgt gggagcagcg actgtaatca tttgggcgaa tgccggtctt 330001 tcggactttc tgtatgaaat gatacctggt tttgctgcga gtctattatc tgtctttttt 330061 gtcagcatat tgacgcaggc tccgtcacaa gctgtcacag accagttcaa cgactaccaa 330121 gatacaatgt cgcaataaag atcgaaagga ggaggaaggg gctgtccctt tttcctcttt 330181 tctcctttta agcggccatt tttttctttt ggaaacaaac gtattttttt ctatacaaaa 330241 agaccccgta tggatatgat taaagtaaaa aaagtatagg agaaaaaggt atggaagagc 330301 ttttagagag agttttttca ttttcagatg ttgataagct aattgatttt attagctatg 330361 aactgcaaaa gccagtgata ctggaaagcg cggatttctt tttgttagcc tataattctt 330421 actatattaa ccattttgat tctgccaacc agcagactat tttttcgaaa aagtgtccgg 330481 tccagatttt tgagaggttt ctgaaggacg gaattattga aaaattgaaa acagagcctg 330541 agccttttcg cgtcaataaa attgaaagca ttgggttaaa ccagagggtg gtcgtgagtg 330601 caaagcacaa aggggaagtc atgggctaca tctggattca ggagctggac caaaatctga 330661 cggatgaaga gctcgacttt ttgtacgaga cctccttcca tgtcgggaaa atcatttata 330721 aaacgaataa attgaaacag gaaaaggaag aaaaagcaga ggatctcatc aaacgggcga 330781 tctatcagca atttacctct gagaaggaac tcagacggga agctgaaagg atcaacaccg 330841 tgctgccttc catgttttca gttgttatcc tgcacgccgc aaatggggat ggggaagcgg 330901 ttgaggattt aaaggaaaat atcaggtcgt acctgaattt acgggataag gtcagtcatg 330961 tcttaacgat cgaatcaaac attgtcatcg tcgtagcgag tttttcccaa aaaagctccg 331021 tctcctcagc agcttctgag tttattaaca agctgttaac acattttcac tttcaaaaaa 331081 tacctacccc tatttatatc ggtatcggaa acgaatataa tcacctatta aaacttggca 331141 agagctacac agaagcactt gaagtcatca aagccgcaga aatcaccggc aatcaggaaa 331201 acattccata tgaatatgcc aaactcggca tttaccgcta tttagaaagc atcgaacaga 331261 aaaatgaatt tttagaatac gagaataaag atttagcttt attaaaagca aaagacgaag 331321 aaagcagcac tgagctgctc aaaaccttgg aaatctatct cctcaacaac tgcaaaacaa 331381 aaccagcggc agaacagctg tttattcacc aaaatacatt gaattaccgc atcaaacaga 331441 ttactgagat gacgtcgatc gatttaagcg atttcagaac gcggtgccag ctctatctcg 331501 atttgatgct gatgaaaaag aaataaaaaa gaaaccagta cttgtactgg tttcgtcttc 331561 acttaaaatc ctctgtaaac atacggatca tcaggttttt taatggtatt ccagtcagtt 331621 actttgacga cagggagagt tgacttgaat ggctggtaat attctgaggc cagagtgccc 331681 ttaatgtgaa tccattcatc atccttgatg tccatgtcct tcggaaattc cacaagcatc 331741 ccgtacacgc cggaatcagc gatacagtga atgatgccaa accttaatac gaacagctga 331801 tttttgttaa ttgcgtttcc tttgtaagca aatccatgaa attctatcgt ccgtccgaga 331861 aattcacccg gatagttata gatggtttcc attcctttta ggaaatcgtc atcggtcaga 331921 gaaatctctt ttttgctgga atacttatta aacagctgtt tcatttgttt gtcatagctg 331981 tcttgcgcgt aataaaggct ggcatcaggc cgcaaatact gtgtttggga gtagtgatct 332041 ccgctctcca tcgccttaaa cgagaaccct tttgttttga ctatggatga gtcaagcgtt 332101 gcaatcggga agaagatgcc tgacaccaaa ggaaaaagaa aaacaacata aatcaaataa 332161 cgctgataaa atggcttgtt ttgttcatgg tcatgctcgt gatcatggcc gcacccgcaa 332221 tcatggtcat ggtgatgtcc gcttttttca ggcgacttga taaatagata tgcttggacg 332281 gcggtcagaa tggccagcag gaagatcgca ataaaggaaa gataggcata tttcatattg 332341 atatattttg ttagatttcc tgaggcatgc agatgataaa agaaaaacgt aaatcccatc 332401 agcaccaata aacgaaacat ccaatcaccc ctttaccagt agtgatcccg ctaaaacaat 332461 cacgacaatg tatgtaatca gcaggaaaac aaatcgtttt ttgaaggccg caagcatcat 332521 caatagattc ttaatatcca ccattgcacc aaagacgaga aaggcgatta acgatcctaa 332581 tgaaaacgtg ctgctgaagg aagacgcgat gaacgcatca acttctgaac aaagcgacag 332641 gacaaacgcc agacccatca tcacgaggga agaggataca tcattctgcc cgatcgcaag 332701 cagagtggat gttttgacat acgtctgcat agcggctgcg ataaaggcgc cgatgattaa 332761 atatttcccc acggagaaaa attcatcaat ggcatgccgc aaggtcccgc ccagtttttg 332821 gagcaaggtg ccgtgatgat gatggtggtg cccgggttca tcaggcttta aaagctggtt 332881 atccttaaat tgataggata agatgacccc gatgatcagc gaaacggcga gagccagtcc 332941 gcctctgtaa aagaccacgc tccatctatt cccgaacgca atataagtag aaaataaaac 333001 gataggatta atgataggcg cggtcagcat gaaagcaacg cccgcatgca gaggaactcc 333061 ctttaacaga agccgcctcg taatcgggat gatgccgcat tcgcaggcgg gaaataaaac 333121 gccggccagc gcaccgaata aaacggcgag aaaacggttt ttcggcatga ttcttgcaat 333181 catttcttca gaaacaaaca tttgaatgat tccggaaagt atgacgccaa tcagaataaa 333241 cggaatggct tctattaaaa tgctgataaa aatagaattc agctgaagaa aagatgattg 333301 tgctgtcaca ataaaacctc cgctcatgtt aagctgcctt tcttatgata ccagaaaaaa 333361 aggcactgct tgtttgacgg aggaggggaa aggatcgttt cactttggtt aggattccaa 333421 aaagccgagt aggatactgc ctgtttctgc agcttctttt ccgagccaaa tcaggtgtcc 333481 ccatgagtga agcaaacaga gaacagcgcc acgaatgtgc tcttttgcat gatgtgcatg 333541 tgacaagtca accaatccgt cataaacact ttgcataatc agcacgggac atatgatggc 333601 ttgcaggtct tttaaagaga cagcggcggt ttgtgacaag tcaatcagaa atccttcacc 333661 cgagcgctgc cggctgttca ttttccgaaa tgcttctatg tctttttcat tcatcaagga 333721 cttgattcgc tgaaacggaa gcgtgctgaa ttgggggctc atagctcgaa acatcaaacg 333781 cgggaaagcg ttattcaagg aagaaatcag cttccatatc cacttttcca ccggcgggcg 333841 gaagagaatt tcccccaatt tatattcagt gtcttttggg gtgagccact ctttggtgac 333901 tgcggattgc agggtcaatg tatttactct ttccggataa tgtgaggcaa agcatatgcc 333961 gctcggccct cctgctgaga tggcgatcac atggacactc tcgatttgta gatgatctaa 334021 taatttcaca tagaaacggc aggcattggc aagacttttt ccaatttctt ttgacgtccg 334081 tccatagcca ggccttgaag gcgtaatgat ggaataccct tgttcaatca acgctgtgta 334141 tccgaattcc tcgtaacaat ttgaatgccc gccatgcatg acaaggatcg gagttccctt 334201 gcctgtcaca gaatattcta gtgtaccgcc atcgaaggtg atcgtttcaa ctcgtctttt 334261 catctgtttc acccaattgg tttttgccta ttatagagtt ttcagcaatt gaccacaagg 334321 tagaagaaat gaataaacaa aggcccttga aatatgatat actttgtatt gatattcatt 334381 ctcaattaaa actttgatat agatgtgaac gggaggcagg acggatggct gagaatcaag 334441 aggtatatga cgttacgatt ataggcgggg ggccgatcgg gctgtttact gctttttact 334501 gcgggatgcg ggagctgaaa acaaaggtaa tcgaattttt gccgaagctc ggagggaagg 334561 tgtctttatt ctttcctgag aaaatcattc gcgatatcgg cggcataccg gggattgcgg 334621 gaaagcagct gatcgagcag ctgaaggagc aggcggcaac gtttgatcct gatatcgtat 334681 tgaatcagcg tgtgaccggg tttgaacgcc tagatgacgg caccattgtt ctgacgggtt 334741 ctgaagggaa aaagcactat acaagaactg tgattttggc ttgcggcatg ggtacacttg 334801 aggtcaatga gtttgacagc gaggatgcgg cccgatatgc gggcaaaaat cttcattatg 334861 gagtggagaa gctcgatgcg tttaaaggga aacgcgtggt gatatcaggc ggcggagata 334921 ctgcggtcga ttgggctaat gagcttgaac cgattgcggc gtctgtgact gtcgttcatc 334981 ggcgtgagga attcggcgga atggaaagca gcgtgacgaa aatgaagcaa tcatcggtgc 335041 gggtgcttac gccttatcgg ctggagcagt tgaacggaga tgaagagggc atcaaaagcg 335101 tgaccgtttg tcatactgag tctggccaga ggaaagacat agaaattgat gagctgatca 335161 ttaatcatgg gttcaaaatt gatctcgggc cgatgatgga gtgggggctg gagattgaag 335221 aaggaagggt gaaagctgac agacatatgc gaacgaatct tccgggcgtg tttgtggcgg 335281 gcgacgcggc tttttatgaa agcaagctga gattgattgc cggcggattt acggaaggcc 335341 cgacagcggt caacagtgcc aaggcttatc tggaccctaa ggccgagaat atggcgatgt 335401 attccaccca tcataaaaaa ttggtgcata aataaaacag cccttgagga aaagggctgc 335461 ttgccatcag gtgtgaagga gttttttctc tgcatgttga ttgtggatga aagctagcaa 335521 ttcatcctgt tcttgtacgg ctgtgaatcc ataaatgccg gcagctgagt catcgcctat 335581 gcagacgata ggagggcggc ttgctgacgg ttccggcaaa atgccaattt gttcgccacc 335641 attgatcaat tgctgaacgg acagcttgtt tgggcaaatg accatgtgca gcggggattc 335701 actgatggta cgctgaatca tgtgggtgaa ccggtcatct atgacgtttt catgagtgat 335761 ataaaacgaa caggattcat gcttttgcat gttttccact gcatggcggc tcccgacaac 335821 aagacgtttc tctgaatcag gctgaatggc ggtgacaaga aagccccgtt tctcaagctc 335881 tgtctttgct tgctcagatg ctgcactcag tttggctgtc agctggcgga tgtcgatttt 335941 ctgagaagcc agtgctctga aaaattcaca aaccgcccgg cgcgatgtga aaaaaacgtc 336001 ttcaaaggtg ccaatctttc gaagaatttc ttcattgaca ggcatgtttt cggtccgcca 336061 tttcggccac tcgatgagat cggcgccgga atcgcgcagc ttgtctgcaa gcgggtcttc 336121 atcttcgcca tgagtcacaa ccatcaaatg ccgtccgatg agcggtttgc tttcaaacca 336181 gctgtgtgtt tgaaagttga cgatgtctcc gatgacgata atcgcagggt ttgtaatctg 336241 gtgttcctgc actttttgct gaatgttctc aagtgttcct ttcacactcc gctggcggcc 336301 ccacgttccc cattggatga caatgacagg gacagaaggc gatttcccgt atgaaataag 336361 ctgctggcaa atataagaca agttcttgac acccatgtaa aaaacaaggg tttgaacgct 336421 tcgggccagc ccttcccagt caaggttcgg cgtgcctttt aatgatttat catgcgctgt 336481 aatcatggca aaagacgatg caaaatcccg atgcgtgacg gggatgcccg catatagcgg 336541 cgctgcaatt ccagaggtga ttcccggcac catttcatag cgaatgccgt gctcatgaag 336601 agcatctgct tcctcgccga ctctgccgaa tacgctcgga tctccgccct tcaagcgaac 336661 gacggttaac ccatttaatg ctttttcaac cagcagggcg ttaatttctt tttgtttcat 336721 aaaatggcgg tttggcagtt ttccgcaata aataaactgg cagtccggtg atgcaaattc 336781 gagcagcttc gggttggcga gccggtcata taaaatcaca tctgcttcct tgagcgcctg 336841 ttttcctttg atggtgagca ggcctgggtc gccgggtccg gctcccacga aatatacgat 336901 tccgttcttc atgatcatgt catccttccg tcactgtaaa aaatgaagga ccactagaaa 336961 agtgatccgg tcttttgatc aatatacgag ataaacatgt tctccttcga tcagcgtttc 337021 atatgttttg acgcatccgt ggtcaggttc ttggacgatt ccgtcttcta aggaaatttt 337081 ccagtcgtgc atcgggcaga aaacatattg accgctgacg atgccttctg ccaggacgcc 337141 gcccttatgc ggacagcggt tttcaatggc gcggatgctt ccgtctgaaa gcttgaaaac 337201 cgcgagctcc ttatcttcaa tatacactgt tttgcctaat tgttcaggca attcttcaat 337261 ttttccgata catacttttg ttacgtcttt gtttaccatg tccattcctc ctcaatgata 337321 gtttttgtca ttatgatgtg gtcacgacat tttcaaataa ttctttagag gtttgtttat 337381 cctctaaaaa gtctttccac ggatccttgt ggacagagag tgtttcattc attcggccgt 337441 tcagctcctg ccgcttttcc ggatcgttta acacggattg gacatgggat aaaccgacgc 337501 gctcaagcca tgcggacgta cgctccagat agtttgcggt ttccctgtaa tattgcaggt 337561 aagcgcccgc gtattctaag acttcttcat ttgttttcac cttcatcagc aaatcgccgg 337621 cacgcaaatg ggttccgccg tttccgccga cataaagctc ccagcctccg tcgatgccga 337681 caacgccaag gtccttaatg ccggattccg cacagtttcg cgggcaggca gacacggcca 337741 ttttgacttt gtgaggcgtg ttcagccctt cgaatttttt ctcaagcgca atgcccagtg 337801 ccatggagtc ttgtgtgccg aagcggcaga attgctcgcc tacacatgtt ttcactgtgc 337861 ggagcgtttt tccgtacgcg tagcccgatg gcatatcaag atcttcccat accttcggaa 337921 ggtcttcttt tttcacgccg ataagatcaa ttcgctggcc gcctgtcatt ttcacgagcg 337981 ggatctcata tttgtcaacg acatcggcga tcttgcgcaa atctgtggag ttggtcacgc 338041 cgccgtacat ccgaggaacg actgagtatg ttccgtcttt ttgaatattg gcgtgcattc 338101 gttcattaac aaagcgggat gtccggtcat cctcgtattt ggttggattg atcatgccta 338161 agtagtagtt cagagcgggt cggcatttag aacagccttc tggcgttttc cagccgagca 338221 cattcatgac ttctcttgta tgtgacagcc ctttggcttt gatttcttct acgacttcat 338281 ctctcgacaa tgtggtgcag ccgcaaatgg cttctttttg cgctgacgca tcaaagtctg 338341 atccgagcgt atgctggagg atttcttcta cgagcggctt acagcctccg catgagcggg 338401 atgcgccggt gcatgctttg atttcgtccg ttgacgagca gcccttttcc tgtatggctt 338461 gaataatcgc accttttgac acgccgttac agccgcagat gatttcatcg tcgctcatcg 338521 ctgcggttat gcttgtgcct gcttcctggc tgaggggctg taagattgat attttagagg 338581 tttcagagat atcggcttct ttttgaatca tagaaaacag gcgattgcct tcgctgctgt 338641 cgccgaataa aacagcaccg acaatttgat tgcctctcag gacaattttt ttatagatgc 338701 cgtcctgctc atcgaagact ttaatcgctt ttttctcctc tgattcgtta aagtcaccgg 338761 cagagaagac ctcgacgcct gataccttta actgtgtgga gagaacggag ccctcatacg 338821 gttttgtttc gatgccgcac atatgctttg ccagcacttt tgcctgttca tacagcggcg 338881 ccacaagccc gtaggcgatt cctcggtgct cggcacattc gccgaccgcg taaatgtgcg 338941 ggatttcagt ctgcatataa tcgttgacga tgatgccgcg gttaaccgga atgccgctct 339001 cggccccgag cgttgtattt gggcggatgc cgacagccat gacgactaaa tcagcttcaa 339061 tgcttgtgcc atccttgaat cggaggcctt cgacacggtc gtcaccgaca atttcttctg 339121 tttgcttttc aagtaaaaag gtcatacctt gtttttctaa ctcgttttgc agcaggcgtc 339181 ctgccgttgc atcaagctgg cgctccatca ggaatggggc aaggtggatg acggacacgt 339241 ccatgccgag attcagcagt ccgcgagctg cttccaaacc aagtagtcct ccgccgatga 339301 cggcagcttt tttatattgt tttgacgcgg cgagcattgt gtctgtatct tttatgtccc 339361 ggaaagctgt gacgcctttt ttgtctgcgc ccggaatcgg aaggataaaa gggaccgatc 339421 ctgtcgccag gatcaattca tcgtaaggct ggattctgtc tgcatctgtg atgactgttt 339481 tgttttccgt gtccactttg atgactgttt catttgtata caattgaatg ttgttttctt 339541 cgtaccagtc ccaatcgttt aacgtaatat ctttaatatc tgtatcgcct tgaagcactt 339601 ttgacaaaag gattcggttg taattgggat gcggttcggc accgaaaatt gtgatctgaa 339661 actcgtcttt agcaacactc agtatctctt caatggccct taccccggcc attccattac 339721 caacaagaac tagctgtttt tttcccatca gatgatccgc tccttatcaa atgttttttc 339781 cagcgtagca cagcaaaaag gaatatttaa gatacatgtt ataaaatgta acaaaatata 339841 cgaaaagttc taaaaatttt atgaaaaatt taaataggta tgattcggac ggcgcatacc 339901 ttaaaaccgg gcattttaca ggctggatct aaggcttccc cgattaaatc attcacattt 339961 tgagcgtctg cccaatggat gggaacaaaa acggtatctt ttctgatttg ttctgataat 340021 ttgctgcgga cggtgatgct tccccgcggc gattctattt ttaccagtac acggtcctcg 340081 atattgtagg tcgctgctgt ttgcggatgg atctccataa acgattcaaa atgtctcgcg 340141 gcaagggcgg cgctttttct tgtttggacg cctgttaagt agtgagacat gactctgcct 340201 gtcgttaaat aaagcggata atcggctgtc ggcttctctt ttggaacagg tggttcgttt 340261 ggaatcacac ttaatgccgc tttttgatcc ggatgagcaa atgattctgt aaacaagcgc 340321 ccagttccgg gatgatcaga ttccggacac ggccaatgaa tgccgccttc acgtctgagc 340381 ctgccgtatg agatgcctga ataatcggca atcccgcctc ggctcgcttc tctcaattca 340441 ttgaaaatat cctccgctga cgtataagaa aagtagcggc ccttgccgag agcggatgcg 340501 agatcacaaa tgatctgcca atcatgcttt gcttcgccgg ggcatggccg gcttgcttct 340561 cttaatgtca cgcgtccttc tacatttgtc atggtgcctt catcttctaa gtaagaggag 340621 gcaggtaaaa tcacatctgc gtatttcgca gtctcagaaa taaacaaatc gattgcgaca 340681 aagaatgtca gtcttcttaa agcctttttc acgagatttg catttggact ggaaacagca 340741 gggttggagc acatgaggaa cagtcctttg atgtcgccgt cattgatttt ttccatcatt 340801 tcataggctg agacaccttt tcgcgggagt tcatcctgat ggattcccca cactttcgca 340861 atatgcgccc ggtgttcttc gttttcgata gaacggtagc ctggaagctg atcggctttt 340921 tggccatgct ctctggcgcc ttgcccgttg ccttgtccgg tgatcgcccc gtagcccgag 340981 taaggtttgc cgatttttcc tgtgatcagc accatgttta agaagccttt cacagccgct 341041 gttccatcgg tttgctgttc aatcccgcgg gctgtaaaca gcatgccgga cgtttccttg 341101 gcaaacttca cagcagcttt tcttatatcc accagcgaga cactcgtctg ttcggcgatg 341161 tcattcaggt ccaacgagtc agtatgctgc ttcagctctt cgaatccatt tgttcgtgat 341221 tgaatgaaat cctcgtttat aagctgttcg tcaatgatga ttttgacgag accgttggca 341281 agggcggcgt ctgtgccggg tttgattttc agatgaagat cggcgatttt cgttgtcgct 341341 gtttcacgag gatcaatggc aatgaagtaa gctccgtttt ctttcgcttt ttcaaaatac 341401 ggcataatcg taggctggca ttccgcaata ttggtgccgg ccagaatgat cacacgggtg 341461 tgggggatgt ctgataaagg attcgttaag cctctgtccg cgccgaatgt ttggttggct 341521 gcggtggctg ctgcggacat acaaagtctc ccgttgtagt cgatgtattt tgtctgtaag 341581 cctactcgtg cgaacttccc taacaaatac gcctcttcat ttgtaatcga ggcgcttccg 341641 tataccgcca tggcgtcatg tccgtgttca gtttggatca ttgtcacttg gtctttgata 341701 tgattcagtg cttcttccca ggaaacaggc ataaactcgc cgtttttctt cagcagcggc 341761 cgggtgatgc gggaggagtt caaggcatgc tggtgagcat tcatgccctt gatgcatagc 341821 cgaccctgtg tcgtaggatt atcaatcccg atcgcagtgt actttttgcg cgtgacgatg 341881 gtttgttcca cgagctgcat tttgcactgc atgctgcaaa acgggcattg agtgtcatat 341941 gttttttctg attggacgtc ttgctgttta tcacggaaat atctaagcag tcgttcagtc 342001 aaaatgcctc atcctttctt atatgcgccc gtctctacag tcgggttttg aatcagtgac 342061 agatctgttt ggaggctttc cagcagctgt gcccttaggt cttcttcgaa tagcacttct 342121 ctgatatgaa cgatcccgag acggtctatc cactgatgaa caccttctaa gtaatgagcc 342181 gtttcccgat aatactggat cagtcctttg atcatgccgg cagtgctgtc ttcgttctca 342241 gtcacgcaaa acaaagctcc tgaacgggca tgagttcccc ggacgccgcc gatgtgaatg 342301 tcccagccag cttgtgtccg aattgcgccg acatcttgca gggcggcctc ggtgcagtct 342361 gtttcacatg ataagctgat agaaatggga gcgggtaagg gaagcatctc aagttgtctt 342421 tcgatttggg ctgccagctg ctgaatcgat cgattttgcc cgcatgtaca tgctttgatg 342481 ctttgcagcg cgtgtcggtg ttcattagtg taaacgggca ttttcaggtc ttttttcatg 342541 ttcgggagat ccgcaggctt gatcccggaa agcttcagcc tttggccgtg agtgatggat 342601 acgtcgggaa tgctgtatgc ctcaatgatg ttggcgatgg ttcttagctg ctccgcgttt 342661 gtccgcccgc cgtacatttg cggaatcagg atgcatgtct cttcagtggc tggctcaggc 342721 tggacaaacc cagggtacag catttccaga tagtattgaa tcgcaggaac acaagtactg 342781 catccgtttt ttgttttcca gtcaagctgg ttcatcactt ctgccggatt agtgaatggc 342841 ctgcgctgaa gctcagcgat gatgtcgtct tctgtaaaat cagtacagct gcaaaacgaa 342901 ggtgtgctgg cgggcttcgt atattcgctg ttggtcatgt atctcaaaag gtcttcaacg 342961 agcggtttgc atcctccgca ggacccagtg gctttggtgc agtgcttgac ttcctcaaca 343021 gttgttaagc tattcgtgtg caccgcgtct tcaatcgcgc ctttcgtcac tgtgttgcat 343081 tggcaaatcg tttcactgga aggcatggat tcaaataaag ggccgcttgt ctccggttcg 343141 atgatctgtt ttttggcaat ggagatgtct cgttgtttaa gcaggctgtc gagaagccgc 343201 tgcttgtcac gggtgtctcc gaataaaata acgccggcca gtttgtcatc tacaaaaagc 343261 gcttttttat aaacgcctgc ttgttcgtcg tagattttga tgctcgtcgt gcgttcatcc 343321 tcttggatct ttcctgctga ccacacatcg attccagcta tttttaacgc cgcagatggt 343381 gctgagcctt gatattcctc acatggaacg ccgcaaatat gactggcgag cgcttttccc 343441 tgctcataaa gcggagccac caatccgtac accgttccgt tatgctcagc gcattcacca 343501 acggcgtaga tattcggttc gcttgtctgc atgaagtcat tcacgatgat cccgcggttc 343561 actttgattc cagcggatac agccaattca atattcggtt tgacgccggc cgccatcaca 343621 atcaagtctg cttttaatga agagccatct ttaaaatgga ttcggtctgc cttcgtggcg 343681 ccggaaatgg agacggtgtc tttctccaaa agaaaggtta ggcctttttg ttccagctct 343741 gtttgcagca gccgcgccgc tgtttgatcg agctgttttt gcataatgcc ggcggagtgg 343801 tgaatgacgc tgacatccat accgagatgc tgtaaaccta ctgcagcttc cagtcctaat 343861 aagccggctc cgattaccgc agccttttga aagtgctggg ccatgttcat cagcgcttgg 343921 cagtcttcta ttgtccgaaa tccatagaca ccttttttgt ctgccccggg gatagggaga 343981 atatgagggg aggagcctgt tgccactatt aatttgtcat acgacagagt gcgtttccga 344041 tctgtgatga cctgctgctg atctgtatca atctgaataa ccgtttcgcc tgtgtaaagc 344101 gtgatcccgt gcttgtcgta ccaatccttg ctgttcagtg taatatcatc gagtgacgct 344161 tcaccctgca atacagagga taagagaatg cgattgtaat tgggatgcgg ctcgcttccg 344221 aaaatgacaa tctcaaacat gtggcgattc agctttaata cttcttcaat acagcggatt 344281 ccggccatgc cgtttcccgc taacactaat ctttgtttct tcatgtatca gacctccttt 344341 ggcgaagctc gtaagttttc tcctattaaa aattatgtca caatgcattg ttaacgcatt 344401 aaacgtgtca caaaaactta cacatgtctt ttccagaaaa taatggtcct atatccttga 344461 ttcagaaaat gtaaaataat gagggtctag aaaggggaat cttatgaagc tgtcggaact 344521 gaaaactagc ggtcatccac tcactttgct ctgttccttt ttatactttg atgtcagttt 344581 tatgatatgg gttatgcttg gggcgctggg tgtttatatt tctcaggatt ttggcctgtc 344641 tccttttgag aaagggcttg tcgtagctgt gccgatttta tctggatctg tgtttcgtat 344701 cattcttggt attttaacgg acagaatcgg accgaaaaaa acggcagtga tcgggatgct 344761 ggtgacgatg attccgctgc tttgggggac attcggcggc cgttccctga ctgagctgta 344821 tgccatcggg attctgcttg gcgtggcggg agcaagcttt gctgtagcgc tgcctatggc 344881 cagccgctgg tatccgcctc atttgcaggg acttgcgatg gggattgccg gagcggggaa 344941 cagcggcacg ttgtttgcaa ccctgtttgg ccctcgtctg gcagagcagt tcggctggca 345001 cattgtcatg ggaattgcgc taattccatt attgatcgtc tttattcttt ttgtatccat 345061 ggcaaaggat tcccctgcac agccgtctcc ccagccgctc aaaagctatc tgcatgtgtt 345121 tgggcaaaag gaaacatggt ttttctgcct gctgtacagc gtcacatttg gcggatttgt 345181 cgggctctca agctttttat ctattttctt tgttgatcaa taccagctgt caaaaattca 345241 cgcaggggac ttcgttacat tatgtgtggc ggcggggagc tttttccggc ctgtcggggg 345301 cttgatttca gatcgtgtcg gcggcacgaa agttctttct gtattgtttg tcatcgtggc 345361 actgtgtatg gccggagtca gtagcctgcc atctctctca atggttattg ttctattgtt 345421 tgtcggaatg atggggctcg gaatgggaaa cggcgcagta ttccagctcg tgccgcagcg 345481 cttccgcaaa gaaatcggca tggtgacggg aatcgtcggt gcggccggag gaatcggagg 345541 gtttttcttg ccgaacatct taggatctct caaacagatg acaggcacat atgctatcgg 345601 ttttatcacg ttttcctgta tcgcgctgct ggcgtttgca cttgtgcttg ccgcaggcta 345661 ttactggcgg aaaagctgga gcgcggaaag cagcccggcg gatgtttagg attttgacgg 345721 acacgcgttt gtgcgtgtct tttttatttt ctcttgattt tcaacagtga accgatcaaa 345781 ataaatagta attattacga tttgttagtg agaggagttt tctgaatgaa tcaacatacg 345841 ctgctcccga aaaaaacgga gcgtcttcaa tactttggat cggtcagtcc gatcaaaggc 345901 gagaaaccag tggaaaaaga gaaaatgaag gacctgcaaa atatcaggaa ggattatttt 345961 tttgacattc agcatgtagg tgtagctaat gtgtcccatc cagtcacaat cacttctgcc 346021 atgatgcctg ccgagcaaac aacggctgcg aactttacaa tgacttgtaa tttgccgaga 346081 aatcagaagg ggattaacat gagccggtta acagagctgc tgcaagtcta tcatcaaaat 346141 ggctggattc tctcattttc ctctcttcag caatttacga aagagcttgc agaaaacatg 346201 gacacatcat ctgccacagt tgaagtgagg tttccgtggt ttttcgaacg gaaaagcccg 346261 aagcttgaga aagcgggttt gatgcatgct gatatattca tgtctgtcac ctatcgcaaa 346321 gatcagccgt ttaaacagcg tgccggcatc tcagcaaaag taacgactct gtgcccttgc 346381 tccaaggaaa tcagcgaata cagtgcccat aatcagaggg gaacggtcag catttgggcg 346441 gatattcacc cggccgcatc gctgccaagt gatgttaaag ctgatttgct tcacgccgca 346501 gaatcaaatg cttctgcgag actgcatccg gtattgaagc ggcctgatga aaaagccgtg 346561 acagaaacgg cctatgaaaa cccgagattt gttgaggatc tcgcccggct gattgctgca 346621 gatttgtttg agcttgaatg ggtgtcagcc tttgagattg aatgccgaaa tgaagaatcg 346681 atccatcttc acgatgccta tgcgaagctg tgtttttcga aggaagtgga taaaatatga 346741 aactctcatt attcattatt gcagttctta tgccagtcat cctgctgtca gcctgctccg 346801 atcatgcaga agaacacgca agtatcaata caaagaaaac ggtcgaaaac ataacggacg 346861 ttcgaaaaac agcaaaaaca agcattgatt ggacaaagcc ttcgggcgga gaatacccgg 346921 atattaaaca gaagcatgtc tggattgatg tgaatgtgaa ggagcagaag gcttacatca 346981 aggaaggaag caacaccatc tatacaatga tgatttcttc tggtcttgat caaacaaaag 347041 atgatgctac gccaaagggc accttttatg tagagcctga acggggagaa tggtttttct 347101 ccgaaggata ccaggaaggc gcagaatact gggtatcatg gaaaaatcac ggtgaatttt 347161 tatttcatag tgtgccaatg actaaggatc aaaaagtcat caaaacggaa gcagaaaaac 347221 taggaacgaa agcatctcac ggatgtatca ggctgaccat tccagatgcg aaatgggtat 347281 atgaaaatat ccctgaacat acaaaagtgg tgatcagctg aattgaaaac cgttgacaaa 347341 aaggaaaaaa gaccatacaa tttaaatcgt aacaattacg ttttatgata aatggcttat 347401 cattgtctgt gcatctgtga aaagcggaaa ggcatcgatt aaggatcttg ctgtcggcaa 347461 aggcaaggat ttgcgatggg gaaaaggatt aaacgcggtt ggagtcttta ctgatttaga 347521 aatcgggcgg cagcgagaaa tgagcgcgaa aagctgctct acaccattgt acatacggcg 347581 aagtattcaa tttaaatcgt aatcattcta ttttaatgga ggcactatta tgaaaaaaat 347641 tccggttacc gtactgagcg gttatctcgg tgcgggaaaa acaacattgc tgaacagcat 347701 tttgcaaaat cgcgaaggct tgaaaatagc ggttatcgta aacgatatga gcgaggtgaa 347761 cattgacgcg ggcttggtta agcaggaagg tggcctttcc agaacagatg aaaagcttgt 347821 ggaaatgtca aatggctgca tttgctgcac gcttcgcgaa gacttattaa ttgaagttga 347881 gaagctggca aaagacggac ggtttgatta tatcgtcatc gaatcgacag gaatcagcga 347941 accgatcccg gtggcccaga ctttctctta tatcgatgaa gagatgggaa tcgatcttac 348001 aaaattctgt cagctggata cgatggtgac ggttgttgat gccaaccgtt tttggcatga 348061 ttatcagtca ggcgaaagcc ttctggaccg caaagaagca ttgggggaaa aggatgaaag 348121 agaaatcgcc gacctcttga tcgatcaaat tgagttttgc gatgtactga tcttaaataa 348181 atgtgatttg gtcagcgagc aagagctcga acagcttgaa aacgttcttc gtaaactgca 348241 gccaagagcc aggttcattc gttccgtcaa aggaaatgta aaaccgcagg agattttgca 348301 tacagggtta tttaacttcg aggaagcgag cggatcggcc ggctggattc aagagctgac 348361 ggcaggccat gcggaacaca ccccggaaac agaagaatac ggtatctctt catttgtata 348421 taagagacgt ttgccgtttc attctacacg attttaccgt tggttggatc aaatgccaaa 348481 gaacgtggta cgtgccaaag gaatcgtctg gtgcgcatct cataacaacc tcgctttgct 348541 gatgtcgcaa gcaggtccgt cggttacgat tgagcctgta tcttattggg tggcggcgtt 348601 gccgaagctt gagcaggagc aagtcaaaca gcaggagccg gaaatcctgg aggagtggga 348661 cccggagttc ggcgaccgcc taacgcagct agtttttatc ggaactgacc tggatgaaga 348721 aacgatcacg aaagagcttg atcaatgcct gttgactgag tatgaatttg attccgactg 348781 gtcgctgttt gaggacccgt ttaaatggaa gctgaatcaa tagaaaaaaa gccgtcccat 348841 ggggaacggc tttttttaat gaaacgtttg tttaaacata atgagcgtat tttttctcaa 348901 ggatattctg aaagaccgcg gcaatggagc agatggccca ataaatgaga gcggtcagaa 348961 tatacatggt catataatca aactctctgc ccccgatgat tttcgcatgc tggagcaatt 349021 ccggcactgt aatcatcgca gcgagagagg acgccttgat caagtcgagc aatacattgg 349081 caagcggagg cagcgcaata cgtatcgatt gcggcaaaat gatgcccctc atcgtctgcc 349141 aataggaaag acccagcgag gatgcggctt cccactgtcc tttttcgacg gatgaaatgg 349201 ctgaacggtt aatttccgca atgtaggcgg cgctgtttag gctaaagccg attaaagcag 349261 ccgtgacagc ggaaaattca atgccgatat aaggaaaccc gaaataaagg ataaacaaaa 349321 tcaccaaaat cggaacgcct cgcataaatg agatatagag cttcgccggc catcttaaca 349381 aagcaagttt agacattctg gcgagtgata tgaacaggcc gatcacagtt cccgcaaaca 349441 tgcttacaaa agagatgagc agtgtataac caatgccttt tatgacataa gggaacgatt 349501 caatggccag cttcgtgttg aaaatatatt cccactgaat gctattgatc atggcgtccg 349561 attacaaatc aacgtcctga acgtcggcat caattttttt tgatacatct gctttattga 349621 agaattgttt cgacagttta gtcaaagagc catccttgct catctctttc aatgcttcgt 349681 tcatcttttt ctgaagtgcc gcattgcttt ttttcatgac aagggcctgt ttgttcggca 349741 tgtacttgat gtcaggatga attgtaatgt tgagatccgg gaatgccgcg agcgcaagtg 349801 tctgcaggta atagtcgttt aaaatgacgt cagtgcgtcc gttggcaaca tcttttaaat 349861 attgctcatt cgtcgcatta tcataaatca cttctttggc gccgtatttt ctcgcgacct 349921 ccatgtagac ggttgtagcc gcgccagccg ctttcttccc ttttaaatcc ttgagcgttt 349981 taatccctga taaatcgtct tttcggacaa ttgccgtgcc gtatgaatat ttatatggag 350041 tggaaaatgc gaacttctcc tcacggtcct tcgtcacatc gatgtcattc gcggctgcgt 350101 caacctgtcc gctgttcacc gctgtcagca tcccgtcaat gcccatctcc ttgaactcaa 350161 ccttcagccc caagcgtttt gccgcttcac gaacaacttc aacctcgtag cccgtcagct 350221 tatcagagcc agagtcagta tcgtgataag aagtgggata gagcgtacct gatgtagcga 350281 ctacgatttt ccctttatcc ttaatctgct cccagcctgt atccttggaa tcggcttcat 350341 ttttgccgga acaggctgcc aatataagaa agaaagccat tgtgaaactg aatataacgg 350401 ctttggaatg catgaatgat ttcacctata gttcccccaa tctgttaatc aactaaaaag 350461 atagcattga acataagggg ttgcaatatg ttgatcgcgt tttcaaaaag ttcgaattgt 350521 gtatacaaaa agcatgggtg ggtgtttaaa agcgtctatg aagggaagag gtgatgaaaa 350581 aaggaattgt ccaaggatga atgccagacg taccaaggaa acgcatgtga aagtgaagga 350641 tgcagcagac ccgtcactca tctatgccaa taccggaaga aatggtcaag aggcatgaaa 350701 ccgatcttca gaataaattt aagtcttgct gatgccccta aggcatatga tatattcgat 350761 gagaaagaaa atggaaacat ttaaaccata atggggagtc aaatgaatat ttacaaacca 350821 gccggatttt ggatcagact tggagctgca ttgttagact acattatagt ctccgtgccg 350881 cttttgctga tctattggct gattacagga aaagacccaa acgacagcat gttcatcagt 350941 ttggttgttc tgctgtattc tattttgctg ccgatgtttt ggcgcggtta tcttatcgga 351001 aaaaggatct gcggaatcag aatcgtaaaa aaagacggat cacaggtcag tctgttaaca 351061 atgtttttac gggttattgt agccggcctg gtttactgta taaccttcgg actcggcttg 351121 atcgccagcc tgattctgat tgccgtacga gaagacaaac ggaccctgca tgatttaatc 351181 gcgggaacat atgtcactta tgcgacacca ggtgaagagg aacttaatgc tgacgaagag 351241 attagaaaga gcgaataatg gttcgctctt tttattttta tgcataaaaa atacaaggca 351301 gcaaaacata tgaaaaatag gattggagga ataaaatgga tgaaacgaat aaccatcaac 351361 attatcacaa tgttcattgc agcggctgtc atttctctga ccggtacagc tgaggccgct 351421 gaaaaacagc agcagtctcc cgcaaatgtt acactgacag atcagcaaaa gaaagagatt 351481 gaacaactgg aagcagagat tcttaaaaag cgcaaagacg tgatctcaaa gtatgtacaa 351541 tacggtatcc tgcctaaaga aagaggagaa cacatcaaaa atcacttgga caaacacttt 351601 gaaatgatga aacaaaacgg ctttgttcca aagcaccatc ctcatccgca taaatttgaa 351661 aaaagacatt aagattttaa gcatccaatg ggaattgggt gcttttgcgt tatttacagg 351721 taggcaatat tagctgagct gttccgcgac taacatcgag ttgatatgaa acgcgtttca 351781 tagcctatga taggtttatc aaataattca ggagtgataa acactatgat ccaccagcat 351841 ccagaatctt ttccgaaaca ttttttgtgg ggctctgctt ctgcagcgta ccagattgaa 351901 ggcgcttgga atgaagatgg caaaggccct tctgtttggg atgtgtttac gaaaataccg 351961 ggcaaaacgt ttaaaggaac caatggcgag attgcggttg accattatca ccgatttaaa 352021 gaagatgtcg ctctgatggc tgagatgggg ttaaaagcat atcgattttc cgtcagctgg 352081 ccacgggttt ttccaaaagg aaaaggagag atcaatgaag caggtctagc gttttacgat 352141 agtctgattg atgaattgct ttctcatcac atcgagccgg ttctgacttt atatcactgg 352201 gatttgcctc aagcgcttat ggacgaatac ggcgggtttg aatccagaaa catcatagag 352261 gattttaatc actactgtat tactctttat aaacgttttg gagacagggt gaaatattgg 352321 gttacgttaa acgaacagaa ctacaatttt aatcacggat ttattacagc catgcatccg 352381 cctggagtga aagacagaaa acgattttac gaagcaaacc atattgcgtt tctggctaat 352441 gcaaaagcca tcgaatcatt tagagaatat gtgcctgaag gcaaaatagg tcctagcttt 352501 gcttattctc cggcttaccc tttatcaagt catccagagg atatactggc atttgaaaac 352561 gccgaagaat ttacgaacaa ttggtggctt gacatgtatt gctggggaac ctacccgcaa 352621 attccattcc gctgcttgga aaaacaggga tgggcgccga caattgaagc aggagatatg 352681 gacctgctcg ccaaagggaa gcctgatttt gtaggtgtca attattatca gacgatcacc 352741 tatgaacgaa atccgcttga tggtgtgtca gaagggaaaa tgaatacgac aggccaaaag 352801 ggaaccaatc aggagacggg gatacccgga gtgttcaaaa cgaaaaaaaa tccgcatctg 352861 acaacgagca actgggattg gacaattgac ccaattgggc tgcgtatcgg tcttcgccga 352921 attacaagcc gctatcagct tccagtgttt ataacagaga acggtttggg tgaatttgat 352981 aaagttgagg acggcactgt acaggatgat tatcgaattg attatttgcg ttcgcatctt 353041 gagcaatgca gacaagccat cagtgacggt gtcgatttaa tcggctattg cagctggtcg 353101 tttactgatc tgttaagctg gctgaacggc taccaaaaaa gatacggatt tgtatatgtc 353161 aatcgtgatg aagaaagcac atccgattta aaacgcttga agaaaaaaag cttttattgg 353221 tatcaagatg tcatcaagac aaacggagaa agtttataaa gagtccctga gagttattct 353281 ctcaggggtt tttcattaca cagaaacagc atcaataata taagtgtcgg cgtgcaaatc 353341 tgacatttca gccggcacag tccagcatgt caattgatag tctcctttag gcagatcaaa 353401 ggacagtctt ttagacatga tgctttcaat atgaattccg ttttctgtga catgaaaagg 353461 aacagtcact tttttttcgt aggagtttac tgtttctgaa ctgttcaggc gaaaaagaat 353521 aaaggccttt gtatttcgct gtgcctcaaa ggaaatggct ccgtctgccg cagcatatcc 353581 tttttcaatc gcttcgtcag tccaatccat tacaggaggt gtagaatcct tttgaaatac 353641 agtaaattga tgatatgaaa tcgaaagttc ttgcggcttc catgatttga tcaatgtgct 353701 gttcctcctc tatgtactgt ttactgaatt gtgaataaaa cctttgtgcc gtctgggtaa 353761 tcggtaagcc gatgcccgac ccaagagcct gctccgcggt tgtcagcggg agaaatgtat 353821 tctacagaag ctccctcacc gccttctttg cacatggcca ttggccattc atctctgtca 353881 tacccctttt tggaaggtac gtcctttaat gattgctcgc ggcgttcttc agctccgtct 353941 ctgtcaatag tgcacacctc tgagtgcccc tcatttatcg catccttaat atgcttggca 354001 gtttcgggat accggtcaga tgggaaggcc attgtttcat catattcttt cgtttgagac 354061 gttttttgat cagctgagaa aaagtctcct tttatcaggc cgacagctgc agctgctatg 354121 atgacgatga cgagaagtat cgtttttatg atgtccgtcg tgatgttcac ctcccgcttt 354181 taaaactgac acaagagtaa tccagaaagc atttggtgta aaggtttaaa ttttatgttt 354241 tacgatcagt ttattgcaga aatcgtaatt ttagcagatc gaaatatttg ttttcagcaa 354301 aatacgattg ccaatttaca ataatgatag taagtcatca gccgttttcg gcttgattaa 354361 tcattttaaa ttggcttatg ataccggtaa gctcctcagc taattgagaa agtgtttcag 354421 aagctgcggt aatctcctcc attgcagcaa attgctcctc tgttaatgca gccgcttgcc 354481 gggtattttt agtagattct ttaatgtcgg ccgtattggc tgcaaaggaa tcatttattt 354541 gatgtgcact ggctgaaatg tttgttacag atgctgataa atcactaatc tcggcgctga 354601 tttcacctgt tgcagctgca atttccttaa atgcatctct ggtgcgctgg atcatggtga 354661 ctccttctgc agcttctgtt ttcacatgct caacagatct tgcagaccgg ttcatatcct 354721 tttgtatttc tatgatcagt tttgaaatct gccccgcaga ctgttgagac tcttctgcta 354781 atttccgtac ttcatcagca acaacagcaa agccttttcc ttgttcaccg gctctggcag 354841 cttcaatcgc tgcattcagc gcaagcaggt ttgtctgatc agcaatttgg gtgatgaccg 354901 ataaaatttg ctcaatttgt ttagagcggc cgtctaactg gtgtatgatt tctccgcttt 354961 tctgaattga ctggtgaatc gcatccattt gcgcctgtac atttgcaatt tccttttgtc 355021 caatgtctgc ttttgattga gcgagctgcc ctttgtcagc gatagcggca gtatttgcag 355081 aaatatcccg gatgtctgct gaagcttgtt ttaatgagct ttcactattt tcaattcggg 355141 tgatctgatc ttgggctcca tttgcaatct gctgtacagc ttctgtgatt ttttctgaag 355201 cttgatttgt ttcctctgct ccggctgaga gctgctgaga ggctgacgca agctgaaggg 355261 ctgattgttg tacggtttgt atggtatcgt tcagcttcat tctcatctta ttataataga 355321 cgcttagttc tgaaagctcg tcaccggttt tgtctgacac ctctattgtc atatctccgt 355381 ttccggcact ttcaaaggcg ctttttaaag cgttcagccg cttgttgatt tttctggtga 355441 aaaccaagac aaggatgact gataccataa tgacgataac aagaacgata gcgaattgag 355501 tgaaaagtga ttgtgtaagt gatgctaaaa tactttgatt agctccggta tacagcatgc 355561 cgatgatgtt cccattttga tcttttaacg gcatgtatgc agtctgataa gaagaacctg 355621 ctacatctgc ttgtccgtaa aaacgctttc ctttctttaa aacagcggca ataacttcag 355681 aagaagcctg ggtgccgacg gctctttcgc catttttcat gacattggtt gcaacacgag 355741 tatcgccttg gaaaatggta atggtatcac ctgtcttttc accaagcaga tcaacaatat 355801 cttcatttcc attgatttgt gtttgccctt tatagagctt attgtttttc acctgccagt 355861 cgcctgacat gacatcatca atataagtgc tgcttaaagc gagatcacct ttcgcttttt 355921 cagttgccat ttgtttcatg ctttctgtaa tttccttaag catcacagtg ccaactgatg 355981 ccgaaaacaa aagaatcacc acgaaaacga ggcaaagaat tttagttcct agcttcatct 356041 taaatcgttt tatcaacata attcctccct ttacgatttg caggtcatat tacttatcgg 356101 gtttttgggt ttaaagtttt attttagaaa aaataaaacc ggcctgatct tcaggccggt 356161 tgtgtgatgc tattcaaggt ttgcgtggtg agtgaacata gtttcagaat cgagaccttt 356221 tttctccatg agttttaaaa tcactgcatc atagaagagc agcaaagttt gttcaaataa 356281 tgatcccatt ggctgaatgg ttttatagct tccgttagac tggtctttag gggaaccagg 356341 cattctgatg atgaggtccg cttgttttcc gatgcttgat tccggattga tggttaaagc 356401 ggcaacaatt ccgtgtaagc tttttgcttt tgctgcggta tgaatcaagc tctttgtctc 356461 gcctgatcct gagccgataa taactagatc tccttcggcg agcggcggag tgagaatctc 356521 acctactata tgggcgttga agcccatgtg catcagtctc atcgcgaagg attttgccat 356581 caggccagac cgccccgcac ccgcggtgaa aatttggtgg gatgaaagaa tgtgatcggc 356641 aagctggtca gcttcttcat tagaaatata agctgctgaa ttgtgtaact cattgagaat 356701 ttccgctacg tattcagtcg ttttcatcgg agttatcctt ggacaatcag ctgcttcatt 356761 tttgaagctg tttccgcctt atcagctgcg cttgtaattc cgcccccgac aatgacaagg 356821 tcaggctttt gctggatcac ttctggcagt gtatcaagtt tgatgccgcc cgcgattgcg 356881 gtttttgcgt tttttacggt atttttgatt gtcgttaatt cttcgaaaga gtttttgccc 356941 tctgcttgaa gatcatagcc agtgtggacg cagatgtagt caacaccgag tgcgtcaatt 357001 tctttcgcac gggattcgat atctttcacg ttaatcatgt ccactaagat tttcttcttt 357061 tgttttttgg cttcttctac tgcgccttta atcgttgcat cgtctgtagc ccctaaaacg 357121 gtgatgatgt cagcgcctgc ttccgacgct ttcataattt cgtagcctcc ggcatccatg 357181 attttcaggt ctgcaagaac cttcaattga ggaaatgctt cttttatttc tttaacggct 357241 cttaggcctt cattgatgac gaccggtgtt ccgatttcaa ctacgtcgat gtattgttct 357301 acctctttga caagctcaat ggcttccggg atgttgacga ggtctaatgc aagctgtaat 357361 tccattgttg atccactccc tttttcgaat tattgttcat tctataggtt ccttcttttg 357421 ttgagaagta ggcactttga agtcaacaag ttacttggag gatactgtga ggagagacaa 357481 tcagatttct ttcgcttgat tttatgagtg agtataatga aaaaagagtc tgcaaaaaag 357541 taagtaagtg atgatacgta tctaacatac aaaaaggtta ctaagggggg ggattctatt 357601 gagccggatg gacgacaaaa ggtttaattg tgagaaggaa ttaacgcttg cagtgattgg 357661 cggtaaatgg aaaatgctca ttttatggca tttaggaaaa gaaggcacaa aacggttcaa 357721 tgaattaaaa acattgattc ctgatattac gcagaagatc ctcgtgaatc agctgagaga 357781 gcttgagcag gatatgattg ttcacaggga agtgtatcca gttgtcccgc cgaaggttga 357841 atattctctg accccgcacg gagaaagcct catgcctatt cttgaagcca tgtatgagtg 357901 ggggaaaggc tatatggaat tgattgatat cgacaaaaat gtcatgaaag aatcgttgta 357961 agacgctctt cgcaagggtg tctttttttg cctttttttc ggtttttgcg cggtacacat 358021 agtcatgtaa agattgtaaa ttgcattcag caataaaaaa agattgaacg cagcagtttg 358081 gtttaaaaat ttttattttt ctgtaaataa tgtttagtgg aaatgattgc ggcatcccgc 358141 aaaaaatatt gctgtaaata aactggaatc tttcggcatc ccgcatgaaa cttttcaccc 358201 atttttcggt gataaaaaca tttttttcat ttaaactgaa cggtagaaag ataaaaaata 358261 ttgaaaacaa tgaataaata gccaaaattg gtttcttatt agggtggggt cttgcggtct 358321 ttatccgctt atgttaaacg ccgcaatgct gactgacggc agcctgcttt aatagcggcc 358381 atctgttttt tgattggaag cactgctttt taagtgtagt actttgggct atttcggctg 358441 ttagttcata agaattaaaa gctgatatgg ataagaaaga gaaaatgcgt tgcacatgtt 358501 cactgcttat aaagattagg ggaggtatga caatatggaa ataacttttt accctttaac 358561 ggatgcacaa aaacgaattt ggtacacaga aaaattttat cctcacacga gcatttcaaa 358621 tcttgcgggg attggtaagc tggtttcagc tgatgcgatt gattatgtgc ttgttgagca 358681 ggcgattcaa gagtttattc gcagaaatga cgccatgcgc cttcggttgc ggctagatga 358741 aaacggggag cctgttcaat atattagcga gtatcggcct gttgatataa aacatactga 358801 cactactgaa gatccgaatg cgatagagtt tatttcacaa tggagccggg aggaaacgaa 358861 gaaacctttg ccgctatacg attgtgattt gttccgtttt tccttgttca ccataaagga 358921 aaatgaagtg tggttttacg caaatgttca tcacgtgatt tctgatggta tctccatgaa 358981 tattctcggg aatgcgatca tgcacattta tttagaatta gccagcggct cagagacaaa 359041 agaaggaatc tcgcattcat ttatcgatca tgttttatct gaacaggaat atgctcaatc 359101 gaagcggttt gaaaaggaca aggcgttttg gaacaaacaa tttgaatcgg tgcctgaact 359161 tgtttccttg aaacggaatg catccgcagg gggaagttta gatgctgaga ggttctctaa 359221 agatgtgcct gaagcgcttc atcagcagat tctgtcgttt tgtgaggcga ataaagtcag 359281 tgttctttcg gtatttcaat cgctgctcgc cgcctatttg tacagggtca gcggccagaa 359341 tgatgttgtg acgggaacat ttatgggcaa ccggacaaat gcgaaagaga agcagatgct 359401 tggcatgttt gtttctacgg ttccgcttcg gacaaacatt gacggcgggc aggcgttttc 359461 agaatttgtc aaagaccgga tgaaggatct gatgaagaca cttcgccacc aaaagtatcc 359521 gtataatctc ctaatcaacg atttgcgtga aacaaagagc tctctgacca agctgttcac 359581 ggtttctctt gaatatcaag tgatgcagtg gcagaaagaa gaggatcttg cctttttgac 359641 tgagccgatt ttcagcggca gcggattaaa tgatgtctca attcatgtaa aggatcgatg 359701 ggatactggg aaactcacca tagattttga ttaccgcact gatttatttt cacgtgaaga 359761 aatcaacatg atttgtgagc gcatgattac catgctggag aacgcgttaa cgcatccaga 359821 acatacaatt gatgaattaa cactgatttc tgatgcggag aaagagaagc tgcttgcgag 359881 ggccggcggt aaatctgtga gctaccgtaa ggacatgacg ataccagagc tgttccaaga 359941 aaaggctgaa ctgctttctg atcatccagc ggttgtattt gaagatcgca cattgtccta 360001 tcgaacgtta catgagcaat ctgcacgcat cgccaatgtg ctgaaacaga aaggggttgg 360061 cccggacagt cctgtcgcgg ttttgattga acgctctgaa cggatgatta cagctatcat 360121 gggaatttta aaagccggcg gagcctatgt gccgattgat ccgggttttc ctgctgagcg 360181 cattcaatat attttggagg actgcggggc ggatttcatc ctgactgaat cgaaggttgc 360241 ggcgcctgaa gccgatgctg agctgattga cttagatcag gcgattgagg aaggtgcaga 360301 agaaagcctg aatgcagatg tgaacgctcg gaaccttgcc tacattattt acacatcggg 360361 aacaaccgga cgcccgaaag gcgttatgat cgagcatcgc caggttcatc atttggttga 360421 atctctgcag cagacgattt atcaaagcgg cagccaaacc ctgcggatgg cattgcttgc 360481 gccgttccac tttgatgcgt cagtgaagca gatcttcgcg tcgcttcttt tgggccaaac 360541 cctttatatc gtaccgaaga aaacagtgac gaacggggcc gcccttactg catattatcg 360601 gaagaacagc attgaggcga cggacggaac accggctcat ttgcaaatgc tggcagcagc 360661 aggcgatttt gaaggcctaa aactgaagca catgctgatc ggaggagaag gcctgtcatc 360721 tgttgttgcg gacaagctgc tgaagctgtt taaagaagcc ggcacagcgc cgcgtttgac 360781 taatgtgtac gggccgactg aaacgtgcgt tgacgcgtct gttcatccgg ttatccctga 360841 gaatgcagtt caatcagcgt atgtgccgat cgggaaagcg ctggggaata accgcttata 360901 tattttggat caaaaaggcc ggctgcagcc tgaaggcgtg gcgggtgagc tttatatcgc 360961 gggagacggt gtgggccgag gctatttaca tttgcctgaa ttaacggaag agaagttttt 361021 acaagatcca ttcgtgccgg gcgatcgcat gtaccggacc ggggacgtgg tgcgctggct 361081 tccagatgga acaatcgaat atttaggcag agaggatgac caggtcaaag tccgcggata 361141 ccggattgag cttggggaaa ttgaagccgt gattcagcag gcgccagacg ttgcaaaagc 361201 cgttgttttg gcacgccctg acgaacaggg aaatcttgag gtttgcgcat atgttgtgca 361261 gaagcctgga agcgaatttg cgccagccgg tttgagggag catgcggcca gacagcttcc 361321 tgactatatg gtgccggctt actttacaga agtgacagaa attccgctta caccaagcgg 361381 caaagtcgac cgccgcaagc tgtttgcact agaggtgaag gctgtcagcg gcactgccta 361441 tacagcgccg cgaaatgaga ctgaaaaagc aatcgcagcc atttggcagg acgtgctgaa 361501 cgttgagaag gcggggatct ttgacaattt ctttgaaact ggcggacatt cattaaaagc 361561 catgaccctt ttaacaaaga ttcataagga aacaggcatt gagattccgc ttcaattttt 361621 gtttgagcat ccgacgatta cggctcttgc agaggaagct gatcacagag aaagcaaagc 361681 ttttgcggtg attgaacctg ctgaaaaaca ggagcattac ccgctttcat tggcacagca 361741 gcgaacatat atcgtcagcc agttcgagga tgcgggagtc ggctataaca tgccagcagc 361801 agcaattctg gaagggcctt tagatattca aaagctggag cgcgcatttc agggattaat 361861 ccgacgccac gagtcattga gaacatcatt tgttcttgaa aacagcacgc cgagacagaa 361921 aattcacgat agcgttgatt tcaacatcga aatgattgaa agaggcggcc gctcagatga 361981 ggcaattatg gcttcattcg ttcggacatt tgatttggcg aaagctccgc tgttcagaat 362041 cggtttgctg gggcttgaag agaaccgtca tatgctgctg tttgacatgc accatttgat 362101 ttctgacggt gtatccattg gcattatgct ggaggagtta gcacgcattt ataaaggcga 362161 acagcttcct gatcttcgtc tccagtataa ggactacgct gtatggcaaa gcagacaggc 362221 tgctgaaggg tacaagaagg accaggctta ttggaaggaa gtctttgcag gcgagctccc 362281 ggtgcttcag cttctgtccg attacccaag accacctgtt caaagctttg aaggggatcg 362341 ggtgtcaatc aagctggatg cgggggtaaa ggatcgcctc aatcgtttgg ctgaacaaaa 362401 cggcgccact ttatatatgg tgatgctttc cgcttactat acgcttttgt caaagtatac 362461 ggggcaggat gacatcattg tcgggacacc gtcagcgggc agaaatcact ccgatacaga 362521 gggcattatc gggatgttcg tcaatacgct tgcgattcgc agtgaggtga agcagaatga 362581 gacgtttacc caattgatct cgcgtgtccg caaacgggtg ctggatgcct tttctcatca 362641 ggactatccg tttgagtggc ttgttgaaga tttgaacatc ccgcgtgatg ttagcaggca 362701 tccgctgttt gacacgatgt tcagccttca aaacgcgaca gagggcattc cggctgtcgg 362761 cgatctttcc ttgtctgttc aagagaccaa tttcaagatt gccaaatttg atttgacggt 362821 gcaggcgaga gaaaccgatg aaggcattga gattgatgtg gattacagca caaagctgtt 362881 taaacaaagc acggcagaca ggctgcttac gcattttgcg cgtttgcttg aagatgctgc 362941 ggctgatcca gagaagccga tttctgagta taagcttctt tctgaagagg aggctgcttc 363001 gcaaattcag cagtttaacc cgggcagaac accttatccg aaagataaaa caattgttca 363061 gctgtttgag gagcaagcgg cgaatacgcc agaccacact gcgcttcaat atgaaggcga 363121 atcactcact tatcgtgaac tgaatgaacg ggccaatcgt ttagcccgcg gcattctttc 363181 tcttggagct ggcgaaggca gaactgcggc tgtcttatgc gagcggtcaa tggatatgat 363241 tgtgtcgatc ttggcagtat taaaatcagg ttcggcttat gttccgatcg atccggaaca 363301 tccgattcag cggatgcagc atttcttccg tgacagcgga gcaaaggtgc ttctcactca 363361 gaggaaatta aaggctttgg cggaagaagc ggaatttaag ggcgttatcg tgctagccga 363421 tgaggaagaa agctatcatg ccgatgcgcg aaatctcgca ctgcctcttg attctgcagc 363481 aatggccaac ctgacgtata cttccggaac gactggaaca cctaagggga atatcgtgac 363541 acatgccaat attctccgca cggtgaagga aacgaattat ctcagcatta cagaacagga 363601 tacgattctc ggtctttcca attacgtgtt tgacgcgttt atgttcgata tgttcggctc 363661 tttgttaaac ggagccaagc tggtgctgat accgaaggaa accgttttgg acatggctcg 363721 cctgtcccgc gtcattgaac gggagaacat cagcattctc atgattacaa ccgctttgtt 363781 ccacttgctt gtggacttga atccggcatg cttgtcaacg cttcgcaaga ttatgtttgg 363841 cggggaacgg gcttcggttg agcatgtcag aaaagctttg caaacggttg gaaagggcaa 363901 gctccttcat atgtatggac cgtctgaaag cacggttttc gcgacgtatc atccggttga 363961 tgaattggag gagcacacgc tgtctgttcc gattggaaaa ccggtcagca atacggaagt 364021 atacattctt gaccgtacgg gacacgtgca gcctgccggg attgccggag agctttgcgt 364081 cagcggcgaa ggactcgtga aaggctatta caaccgtcca gaactgactg aggagaaatt 364141 tgttccccat ccgtttacat ccggcgaacg catgtataaa acgggagacc ttgcgagatg 364201 gctgccgaat ggcgacatcg aatttatcgg gcgaatcgac catcaggtga agattcgcgg 364261 acagcgcatc gagcttggag aaatcgaaca tcagctgcaa acccatgatc gtgttcagga 364321 aagtgttgtg cttgccgttg atcaaggagc gggagataaa ctgttgtgtg cttactatgt 364381 cggagaagga gacatctcat cacaagagat gagagagcat gctgcgaagg acttgccggc 364441 atatatggtt cctgcggtgt ttatccaaat ggacgagctg ccgctgacag ggaacggaaa 364501 aattgaccgg agagcgctgc cgattcctga tgccaacgtt tcaagaggtg tttcatatgt 364561 tgcgccacgc aatggaacgg aacaaaaagt cgcggacatt tgggcacagg tacttcaggc 364621 agaacaagtc ggcgcttatg accacttctt tgacattggc ggacattcat tagcaggcat 364681 gaagatgctt gccttggttc atcaggaact gggcgttgag ctgtcactca aggatctctt 364741 ccagtcaccg acggttgagg gcttggcaca ggtgattgcc tctgctgaaa aagggacagc 364801 cgcaagtatc agcccggcag agaaacaaga tacgtatcct gtttcttcac cgcaaaaacg 364861 gatgtacgtg cttcagcagc ttgaggatgc gcaaacgagc tataacatgc cggcggttct 364921 gcgcctgaca ggtgagcttg atgttgaaag gcttaacagc gtcatgcagc agttaatgca 364981 gcgtcatgaa gccttgagaa ccacgtttga aataaaagat ggagaaacgg tgcagcggat 365041 ctgggaagag gctgagtgcg agatagccta tttcgaagcc ccggaagaag agacagagcg 365101 gatcgtttct gagtttatta agcctttcaa aatcgaccaa cttccactgt tcagaatagg 365161 gcttatcaag cattcagaca ctgagcatgt gctgctgttc gatatgcatc atattatttc 365221 tgatggtgca tctgtcggtg tgctgattga ggagctttca aagctgtacg acggagaaac 365281 ccttgagccg ctccgtattc aatataagga ttatgccgtg tggcagcagc agttcattca 365341 gtctgagctt tacaagaagc aagaagagca ttggctgaag gagctggacg gagagctgcc 365401 ggtgctgacg cttccgactg attacagtcg gcctgccgtt caaacatttg agggagaccg 365461 cattgcattt tcattagaag caggcaaagc tgatgctctg cgcaggcttg caaaagaaac 365521 ggattccacg ctttacatgg tgcttctggc ttcatacagt gcgtttttat caaaaattag 365581 cgggcaagac gatatcatcg tcggttcacc tgtggccgga cgatctcaag cggacgtcag 365641 ccgcgtcatc ggaatgttcg tcaatacatt ggcgctgcgc acgtatccga agggtgaaaa 365701 gacgtttgct gactatctta acgaagtgaa agaaacggca ctcagcgctt ttgatgcgca 365761 ggattaccca cttgaggatt tgatcggaaa tgttcaggtt cagcgtgaca caagcagaaa 365821 tccgttattc gatgcagttt tttcaatgca aaatgcgaat ataaaggatt taacaatgaa 365881 agggattcag cttgagccgc atccgtttga acggaaaaca gccaagtttg acctcacgct 365941 gacggctgac gaaaccgacg gagggcttac attcgtactc gaatacaata cagctctgtt 366001 taagcaggaa acgattgaac gatggaagca atattggatg gagcttttag atgcagttac 366061 tgggaacccg aaccagccgc tttccagcct gtcactggtc accgagacag aaaagcaagc 366121 gcttcttgag gcatggaagg gcaaagcgct gcctgtgccg acagacaaaa cggttcatca 366181 gctattcgaa gagactgccc agcgccacaa agaccgcccg gctgtcacat acaacggcca 366241 gtcttggacg tacggcgagc tgaatgcgaa ggcaaaccgt ctcgcgcgga ttctgatgga 366301 ctgcggcatc agcccggatg accgcgtcgg cgttctcacg aagccgtcgc ttgaaatgtc 366361 cgccgcggtg ctcggcgtct tgaaagccgg agcggcgttt gtgccgattg atcctgacta 366421 tccggatcag cggattgagt atattttaca ggacagcggc gcgaagcttc tcttgaaaca 366481 ggaaggcatt tcagtgccgg acagctatac gggagatgtc attcttctcg acggaagccg 366541 cacgattcta agcctgccgc ttgatgaaaa cgacgaggaa aatccagaaa ccgctgtaac 366601 cgcggagaac ttggcgtaca tgatttacac gtctggaacg accggacagc cgaagggtgt 366661 catggtcgag caccatgcgc ttgtgaacct gtgcttctgg caccacgacg cgttcagcat 366721 gacagcggag gaccgcagtg cgaagtacgc gggctttggg ttcgacgctt ccatttggga 366781 gatgttcccg acctggacga tcggtgccga acttcacgtc attgaggaag cgatccgcct 366841 cgatatcgtc cgcctgaacg attattttga aacgaacggc gtaacgatca cgttcctgcc 366901 gacacagctt gcggaacagt tcatggagct tgagaacaca tcacttcgcg tattgcttac 366961 tggaggagac aagctgaagc gcgcagtgaa aaagccgtac acactcgtca ataactacgg 367021 gccgacagag aatacggtcg ttgccacaag cgcagaaatc catccggagg aaggctcgct 367081 ttccatcgga agggccattg ccaatacgag agtatacatt ctcggcgagg gcaatcaggt 367141 gcagccggaa ggcgtagccg gagagctttg cgtggcgggg cgcggactgg cacgcggcta 367201 tctgaatcga gaagacgaaa ccgcgaagcg gtttgtcgct gatccgtttg tgccgggtga 367261 gcgcatgtac cgcaccggcg atttggtgaa atggacgggc ggcggcatcg aatacatcgg 367321 ccggatcgac cagcaggtca aggtccgcgg ctaccggatc gagctctcag aaattgaagt 367381 ccagctcgcc cagctttctg aggtgcagga tgcggcggtg acagctgtca aagataaagg 367441 cggcaacaca gcgatcgcgg cgtatgtcac accggaatca gctgacatag aagcactgaa 367501 atcagcactg aaggaaaccc tgccggatta catgatcccg gcgttctggg tgacgctgaa 367561 cgagcttccg gttacggcaa acggcaaagt ggaccgcaaa gccttgcctg agccggacat 367621 cgaagcggga agcggagaat acaaagcgcc gacgaccgac atggaagagc tgcttgccgg 367681 catctggcag gacgtgcttg gaatgtctga agtcggtgtc accgacaatt tcttctcgct 367741 tggcggagat tccatcaaag gaattcaaat ggcgagccgc ttgaaccagc acggctggaa 367801 gctggaaatg aaagatctct tccagcaccc gacgatcgaa gagctcaccc agtacgtaga 367861 gcgtgccgaa ggcaaacagg cagaccaagg cccggtggag ggcgaagtca tcctgacgcc 367921 gatccagcgc tggttctttg aaaagaactt cacgaacaag caccactgga accaatctgt 367981 gatgcttcac gccaagaagg gctttgatcc tgaacgggtg gagaaaacat tgcaggcgct 368041 gatcgagcat catgacgcgc tccgcatggt ctatcgtgag ggacaggaag acgtcattca 368101 atacaacaga ggtcttgaag ctgcttcagc tcaattggag gtcatccaga ttgagggcca 368161 agctgcagat tacgaagacc gaatagagag agaagcggag cgtttgcaaa gcagcatcga 368221 cttgcaggaa ggcggcttgt taaaagcagg cttgttccaa gcggaagacg gagatcactt 368281 gcttcttgcc attcaccact tagtggttga cggcgtgtcg tggcggattt tactggagga 368341 tttcgccgcg gtatatacac agcttgagca aggcaatgaa ccggttctcc cgcagaaaac 368401 acattcattt gcagagtatg cagagagatt gcaagacttc gcgaactcca aagccttttt 368461 gaaagaaaaa gagtattgga gacagcttga agaacaagct gttgcggcaa agcttccgaa 368521 agaccgcgaa tctggtgatc agcgaatgaa acatacaaag acaattgaat tctcgctgac 368581 tgctgaagag acagaacagc tcaccacaaa ggtgcatgag gcatatcaca cagaaatgaa 368641 tgatattttg ctgacggcat tcggattggc aatgaaggag tggacgggtc aagatcgagt 368701 aagtgttcat ttagaggggc atggacgtga agaaatcata gaagacctga ccatttctcg 368761 cacagtcggc tggtttacaa gtatgtaccc aatggtgctc gatatgaagc atgcggatga 368821 tctgggctac cagctgaagc aaatgaaaga agatatcaga catgtgccga ataagggagt 368881 cggatacggc attctgcgct atctgacggc accggaacat aaagaagatg tggcgttctc 368941 gattcagccg gatgtcagct tcaactattt aggtcagttt gacgaaatgt cggatgcagg 369001 tttgtttacg agatcagagc tgccatcagg acagtcatta agccctgaaa cagaaaaacc 369061 gaatgcgctg gatgttgtcg gatatatcga aaacggaaaa ctgacgatgt cactggccta 369121 tcattctctt gaatttcatg aaaaaacagt acaaacattc agtgacagct ttaaagcgca 369181 tcttctcaga atcattgaac attgcctatc tcaagatggt acggaactga ccccgagtga 369241 tcttggtgac gacgatttga cgctggatga gctggataaa ttaatggaaa ttttctaata 369301 gaggtggcat atgagcaaaa aatcgattca aaaggtgtac gcactgacac caatgcagga 369361 gggaatgctg tatcatgcga tgcttgatcc gcattcttcc tcgtacttca cacaattaga 369421 gcttgggatt cacggcgctt ttgatcttga aatctttgag aaaagcgtca atgaactgat 369481 tcggtcatac gatattctcc gtacggtatt tgtgcatcag cagctgcaaa aaccgcgtca 369541 ggtcgtgtta gcggaacgca aaacaaaagt gcattatgag gatatcagtc atgcagacga 369601 aaaccgccag aaagagcaca ttgagcgtta caaacaagac gttcagcgcc aaggctttaa 369661 cctggcaaaa gacatattgt tcaaggtagc ggttttccgc cttgctgcag atcagctgta 369721 tcttgtctgg agcaatcatc atattatgat ggacggctgg agcatgggcg tcctcatgaa 369781 aagcctgttc caaaactatg aagcgctcag agcaggcagg acaccggcaa acggtcaggg 369841 caagccttat tccgattaca tcaagtggct tggaaaacag gacaatgaag aagcggagag 369901 ctactggagc gagcgcttgg cgggttttga acagccaagc gtgctcccgg gccgcctgcc 369961 tgtgaaaaaa gacgaatacg tcaataaaga atattcattt acatgggacg aaacactggt 370021 tgcccgtatt cagcaaaccg caaatctcca tcaagtgaca gggcctaacc tatttcaggc 370081 cgtttggggc attgttctca gcaaatacaa ctttacggat gatgtgatct tcggaacggt 370141 cgtctcggga cgaccgtctg aaatcaacgg aatcgaaacg atggcggggc tgtttatcaa 370201 caccattcca gtgcgggtga aagttgaacg agatgctgca ttcgctgata ttttcacagc 370261 tgttcagcag catgcagtag aggcagagcg ttacgattac gtgccgctct atgagattca 370321 aaaacgctca gctcttgatg gcaatctctt aaaccatctg gtcgcgtttg aaaattatcc 370381 gcttgatcaa gagcttgaaa acggcagcat ggaagaccgc ctcgggtttt cgattaaggt 370441 agaaagcgca tttgaacaaa cgagcttcga tttcaacctg attgtgtatc cgggcaaaac 370501 gtggaccgtc aaaattaaat ataacggagc cgcctttgat tccgctttta tcgaacggac 370561 agcggagcac cttacccgca tgatggaagc agctgtcgat cagccggccg cttttgtgcg 370621 tgagtacggg cttgtgggag acgaagagca gcggcaaatt gtcgaggtgt ttaacagcac 370681 gaaagccgaa ctccctgaag gaatggctgt tcaccaagtg tttgaagagc aagcgaaacg 370741 gacgccggcg agcaccgccg tcgtatatga aggaaccaag ctgacgtacc gcgagctgaa 370801 tgcagcggct aaccgtctgg cgagaaagct tgtcgaacat gggcttcaaa aaggggaaac 370861 agcagcgatt atgaacgacc gctcagtaga aaccgttgtc ggcatgctgg ctgttttaaa 370921 agcaggcgcc gcatatgtgc cgcttgatcc agcgcttcct ggggatcgtc ttcgtttcat 370981 ggcagaggac agctccgttc gaatggtttt gatcggaaat tcttatacag ggcaggcaca 371041 tcagctgcaa gtgccggttc ttacactgga cataggcttt gaagagagtg aagcggctga 371101 caatctcaac ctgccatccg ccccgtctga tttggcgtac atcatgtaca catccggttc 371161 aacgggcaaa ccgaaaggcg tcatgatcga acataaaagc attctgcgcc tcgtcaaaaa 371221 tgccgggtac gttcctgtta ctgaagaaga ccgcatggcg caaacgggag ctgtcagctt 371281 tgatgccgga acgtttgagg tattcggcgc actgctgaat ggcgcagcac tttatccggt 371341 caaaaaagag acactgcttg atgcgaaaca atttgctgca ttcctgcgtg agcaaagcat 371401 cacaactatg tggctgacat cacctttatt caaccagctt gctgcaaagg atgcgggtat 371461 gttcggcaca ctgcgccatt taatcatcgg cggagatgcc cttgtcccgc atattgtcag 371521 caaagtaaaa caggcatcgc cgtcgctttc attgtggaac ggatacggcc cgacagaaaa 371581 cacgacgttt tcaaccagtt ttctgatcga ccgcgagtat ggcggctcta tcccaatcgg 371641 gaagccgatc ggaaattcca ctgcctatat tatggatgag cagcaatgcc tgcagccaat 371701 cggcgcgcct ggtgagcttt gcgtaggcgg aatcggtgta gcgcgtgggt atgtcaatct 371761 ccctgagctg acggagaagc aatttctgga agacccgttc agaccgggtg agagaattta 371821 ccgcactggt gacttggcaa gatggctgcc ggacggcaat atcgaatttt taggcagaat 371881 cgacaaccaa gtgaaggtgc gcggcttccg aattgagctt ggcgaaattg aaacaaaact 371941 gaacatggct gagcatgtga cagaagccgc ggtgatcata cgcaagaaca aagcagacga 372001 aaatgaaatt tgcgcgtact tcacggcgga tcgtgaagtg gctgtgagtg agctgagaaa 372061 aacactgtct cagtctttgc ctgactatat ggtccctgcc cacctgattc aaatggacag 372121 cctgccgctc acgccaaacg ggaaaatcaa caaaaaggaa ctgcctgcac cgcaatcaga 372181 agccgtgcag ccggaatacg cagcaccaaa aacagagagt gaaaagaaat tagcggagat 372241 ctgggaagga atactcggcg tcaaagcagg cgttaccgat aacttcttta tgatcggcgg 372301 ccattctttg aaagcgatga tgatgacggc gaaaattcaa gagcattttc ataaggaagt 372361 tccgataaaa gtgctttttg aaaagccgac tattcaagaa ctggcactgt atttggaaga 372421 gaacgaaagc aaggaggagc agacgtttga accgatcagg caagcatctt atcagcagca 372481 ttatcctgta tccccggccc agcggagaat gtatatcctc aatcagcttg gacaagcaaa 372541 cacaagctac aacgtccccg ctgtacttct gctggaggga gaagtagata aagaccggct 372601 tgaaaacgcg attcagcaat taatcaaccg gcacgaaatc ctccgtacat cgtttgacat 372661 gatcgacgga gaggttgtgc aaaccgttca taaaaacata tcgttccagc tggaggctgc 372721 caagggacgg gaagaagacg cggaagagat aatcaaagca tttgttcagc cgtttgaatt 372781 aaaccgcgcg ccgctcgtcc gttcgaagct tgtccagctg gaagaaaaac gccacctgct 372841 gctcattgat atgcatcata ttattactga cggaagttca acaggcattc taatcggtga 372901 tcttgccaaa atatatcaag gcgcagatct ggaactgcca caaattcact ataaagatta 372961 cgcagtttgg cacaaagaac aaactaatta tcaaaaagat gaggaatact ggctcgatgt 373021 ctttaaaggc gaactgccaa tactggatct tcccgcggat ttcgagcggc cagctgaacg 373081 gagctttgcg ggagagcgcg tgatgtttgg gcttgataag caaatcacgg ctcaaatcaa 373141 atcgctcatg gcagaaacag atacgacaat gtacatgttt ttgctggcgg cgttcaatgt 373201 actcctttcc aagtacgcgt cacaggatga tatcattgtc ggctcgccga cagctggcag 373261 aacacatcct gatctgcaag gtgtgccggg tatgtttgtc aacacggtgg cactcagaac 373321 ggcaccagcg ggagataaaa ccttcgcgca attccttgaa gaggtcaaaa cagccagcct 373381 tcaagcattc gagcaccaga gctatccgct tgaggagctg attgaaaagc ttccgcttac 373441 aagggataca agcagaagtc cgctgttcag cgtgatgttc aacatgcaga atatggagat 373501 tccttcatta agattaggag atttgaagat ttcctcgtat tccatgcttc atcatgttgc 373561 gaaatttgat ctttccttgg aagcggtcga gcgtgaagag gatatcggcc taagctttga 373621 ctatgcgact gccttgttta aggacgagac gatccgccgc tggagccgcc actttgtcaa 373681 tatcatcaaa gcggccgcgg ctaatccgaa cgttcggctg tctgatgtag atctgctttc 373741 atctgcagaa acggctgctt tgctagaaga aagacatatg actcaaatta ccgaagcaac 373801 ctttgcagca ctttttgaaa aacaggccca gcaaacacct gaccattctg cggtgaaggc 373861 tggcggaaat ctgttgacct atcgcgagct tgatgaacag gcgaaccagc tggcgcatca 373921 tcttcgtgcc caaggggcag gaaatgaaga catcgtcgcg attgttatgg accggtcagc 373981 tgaagtcatg gtatccattc tcggtgtcat gaaggcgggg gcagctttcc ttccgattga 374041 tcctgataca cctgaagaac gaatccgtta ttcattagag gacagcggag caaaatttgc 374101 ggtcgtgaat gaaagaaaca tgacggctat tgggcaatat gaagggataa ttgtcagcct 374161 tgatgacggt aaatggagaa atgaaagcaa ggagcgccca tcatccattt ccgggtctcg 374221 caatcttgca tacgtcattt atacgtccgg tacgaccgga aagccaaagg gcgtgcagat 374281 tgagcatcgt aatctgacaa actatgtctc ttggtttagt gaagaggcgg gcctgacgga 374341 aaatgataag actgtattgc tttcatctta cgcatttgac cttggctata cgagcatgtt 374401 ccctgtactt ctgggcgggg gcgagctcca tatcgtccag aaggaaacct atacggcgcc 374461 ggatgaaata gcgcactata tcaaggagca tgggatcact tatatcaagc tgacaccgtc 374521 tctgttccat acaatagtga acaccgccag ttttgcaaaa gatgcgaact ttgaatcctt 374581 gcgcttgatc gtcttgggag gagaaaaaat catcccgact gatgttatcg ccttccgtaa 374641 gatgtatgga cataccgaat ttatcaatca ctacggcccg acagaagcaa cgatcggcgc 374701 catcgccggg cgggttgatc tgtatgagcc ggatgcattt gcgaaacgcc cgacaatcgg 374761 acgcccgatt gcgaatgccg gtgcgcttgt cttaaatgaa gcattgaagc ttgtgccgcc 374821 tggagcgagc ggacagctct atatcacggg acaggggctc gcgagagggt atctcaacag 374881 gcctcagctg acagccgaga gatttgtaga aaatccatat tcgccgggaa gcctcatgta 374941 caaaaccgga gatgtcgtac gaagactttc tgacggtacg cttgcattta tcggccgggc 375001 tgatgatcag gtgaaaatcc gaggctaccg cattgagccg aaagaaattg aaacggtcat 375061 gctcagcctc agcggaattc aagaagcggt tgtactagcg gtttccgagg gcggtcttca 375121 agagctttgc gcgtattata cgtcggatca agatattgaa aaagcagagc tccggtacca 375181 gctttcccta acactgccgt ctcatatgat tcctgctttc tttgtgcagg ttgacgcgat 375241 tccgctgacg gcaaacggaa aaaccgacag aaacgctctg ccgaagccta acgcggcaca 375301 atccggaggc aaggccttgg ccgcaccgga gacagcgctt gaagaaagtt tatgccgcat 375361 ttggcagaaa acgcttggca tagaagccat cggcattgat gacaattttt tcgatttagg 375421 cggccattca ttaaaaggga tgatgctgat tgccaacatt caggcggaat tggagaaaag 375481 cgtaccgctt aaagcactgt tcgagcagcc gacagttcgc cagctggcgg cttatatgga 375541 ggcgtctgct gtttcaggcg gccatcaagt actcaaaccg gctgacaagc aggatatgta 375601 tccattgtca tccgcacaga aacgaatgta cgtgctcaat cagcttgacc gccagacgat 375661 aagctacaac atgccatctg ttcttctaat ggaaggagag cttgatattt cgcgcctgcg 375721 cgactcactc aatcagcttg tgaaccgtca cgaatcattg cggacgtcat ttatggaagc 375781 taatggtgag cctgttcagc gcatcattga gaaggcggag gttgatcttc atgtgtttga 375841 agccaaagaa gacgaagcgg accaaaagat taaggaattt atccggccat tcgacttaaa 375901 cgacgcaccg ctcattcgcg cagctttgct tcgaatagaa gcgaaaaaac atttgctgct 375961 tttagatatg catcatatca tcgcagacgg cgtctcaaga ggcatctttg taaaagaatt 376021 ggcgctgctt tacaaaggag agcagcttcc ggagccgacg cttcattata aagatttcgc 376081 cgtttggcaa aatgaagctg agcaaaaaga acggatgaag gagcatgagg cgtactggat 376141 gtcagttctt tcaggcgagc tgccagagct tgatctcccg ctcgattatg cccgtccgcc 376201 tgtgcaaagc tttaaaggag atacgatccg tttccgtacg ggaagtgaga cggcaaaggc 376261 ggtagaaaaa ctgcttgccg aaaccggaac gaccttgcac atggtgctcc atgctgtttt 376321 ccacgtcttt ttaagcaaaa tttccggaca gcgggatatc gtcatcggct ccgttactgc 376381 cggccggacg aatgctgatg ttcaggacat gccgggaatg ttcgtcaata cacttgccct 376441 gagaatggaa gcgaaagaac agcaaacatt tgcggagctt ttggagctag caaagcagac 376501 gaacctgtca gcccttgagc atcaggagta tccgtttgaa gatctggtta atcagcttga 376561 tctccctcgg gatatgagcc gaaacccatt gtttaatgtg atggtgacga cagaaaaccc 376621 tgataaagaa cagcttacat tgcaaaatct gagcatttca ccttatgagg ctcatcaggg 376681 aacttctaag tttgatctga cactgggcgg atttactgat gaaaatggca ttggcttgca 376741 gctcgaatat gcgacagatc tgttcgcaaa agaaacagct gaaaaatgga gcgaatacgt 376801 tctgcggcta ctaaaggctg ttgcggataa cccgaaccag ccgctttcca gtctgttact 376861 ggtcaccgag acagaaaagc aagcgcttct tgaggcatgg aagggcaaag cgctgcctgt 376921 gccgacagac aaaacggttc atcagctatt cgaagagact gtccagcgcc acaaagaccg 376981 cccggctgtc acatacaacg gccaatcttg gacgtacggc gagctgaacg cgaaggcaaa 377041 ccgcctcgcc cggattctga tggactgcgg catcagcccg gatgaccgcg tcggcgttct 377101 cacgaagccg tcgcttgaaa tgtccgccgc ggtgctcggc gtcttgaaag ccggagcggc 377161 gtttgtgccg attgatcctg actacccgga tcagcggatt gagtatattt tacaggacag 377221 cggcgcgaag cttctcttga aacaggaagg catttcagtg ccggacagct atacgggaga 377281 tgtcattctt ctcgacggaa gccgcacgat tctaagcctg ccgcttgatg aaaacgacga 377341 gggaaatcca gaaaccgctg taaccgcgga gaacttggcg tacatgattt acacgtctgg 377401 aacgaccgga cagccgaagg gtgtcatggt cgagcaccat gcgcttgtga acctgtgctt 377461 ctggcaccac gacgcgttca gcatgacagc ggaggaccgc agtgcgaagt acgcgggctt 377521 cgggttcgac gcttccattt gggagatgtt cccgacctgg acgatcggcg ctgaacttca 377581 cgtcattgat gaagcgatcc gcctcgatat cgtccgcctg aacgattatt ttgaaacgaa 377641 cggcgtaacg atcacgttcc tgccgacaca gcttgcggaa cagttcatgg agcttgagaa 377701 cacatcactt cgcgtcctct tgaccggagg agacaagctg aagcgggcag tgaaaaagcc 377761 gtacacactc gtcaacaact acgggccgac agaaaatacg gtcgttgcca caagcgcaga 377821 aatccatccg gaggaaggct cgctttccat cggacgggcc attgccaata cgagagtata 377881 cattctcggc gagggcaatc aggtgcagcc ggaaggcgta gccggagagc tttgcgtggc 377941 ggggcgcgga ctggcacgag gctatctgaa tcgagaagac gaaaccgcga agcggtttgt 378001 cgctgatccg tttgtgccgg gtgaacgcat gtaccgcacc ggcgacttgg tgaagtgggt 378061 gaacggcggc atcgaataca tcggccggat cgaccagcag gtcaaggtcc gcggctaccg 378121 gatcgagctc tcagaaattg aagtccagct cgcccagctt tctgaggtgc aggatgcggc 378181 ggtgacagct gtcaaagata aaggcggcaa tacagcgatc gcggcgtatg tcacaccgga 378241 aacagctgac atagaagcac taaaatcaac actaaaggaa accctgccgg attacatgat 378301 cccggcgttc tgggtgacgc tgaacgagct tccggttacg gcaaacggca aagtcgaccg 378361 caaagccttg cctgagccgg acatcgaagc gggaagcgga gaatacaaag cgccgacgac 378421 cgacatggaa gagctgcttg ccggcatctg gcaggacgtg cttggaatgt ctgaagtcgg 378481 tgtcaccgac aatttcttct cgcttggcgg agattccatc aaaggaattc aaatggcgag 378541 ccgcttgaat cagcacggct ggaagctgga aatgaaagat ctcttccagc atccgacgat 378601 cgaagagctc acccagtacg tagagcgtgc cgaaggcaaa caggcagacc aaggcccggt 378661 ggagggcgaa gtcatcctga cgccgatcca gcgctggttc tttgaaaaga acttcacgaa 378721 caagcaccac tggaaccaat cggtgatgct tcacgccaaa aagggctttg atcctgaacg 378781 ggtggagaaa acattgcagg cgctgatcga gcatcatgac gcgctccgca tggtctaccg 378841 cgaggaaaac ggggacatcg ttcaggtgta taaaccgatc ggtgagagca aggtcagctt 378901 cgaaatcgtg gatctgtacg gctccgatga agagatgctg agaagccaga ttaagcttct 378961 cgcgaacaag ctgcaaagca gtctcgatct gcgaaacggg ccgcttttaa aggcggagca 379021 atatcgcaca gaagctgggg atcacctgct cattgctgta caccatctcg tggtcgacgg 379081 tgtgtcatgg cggattttgc ttgaagactt tgcttcaggc tacatgcagg ctgagaaaga 379141 agagagcctt gtcttcccgc aaaaaacaaa ctccttcaag gattgggcgg aagaactggc 379201 ggcattcagc caatcagcgc atcttttaca gcaggctgaa tactggtcgc aaattgccgc 379261 tgaacaggtt tctcctttac ctaaggattg tgaaacagag cagcggatcg tcaaggatac 379321 atcatctgtc ctatgtgaat taacggcaga agacactaag catcttttaa cagatgttca 379381 tcagccatat ggaactgaaa tcaacgatat tcttctcagc gcgctcggtt tgacaatgaa 379441 agaatggaca aagggggcca aaattggcat taaccttgag ggacacggcc gggaggacat 379501 tatcccgaat gtgaatatct ccagaacggt cggctggttt acggcacaat accctgttgt 379561 gctcgacata tctgacgcag atgcctcagc tgtgatcaaa acagtcaaag aaaacctgcg 379621 ccgcattccg gacaaaggtg ttggctacgg cattcttcgt tatttcacag aaacagcgga 379681 aacaaagggc ttcacaccgg agatcagctt caactatttg ggccaattcg acagtgaagt 379741 caaaaccgat ttctttgaac cgtccgcttt cgatatgggg cgccaagtaa gcggagaatc 379801 agaggcgctg tacgcattaa gcttcagcgg catgatcaga aacggccggt ttgtgctttc 379861 ctgctcctac aatgagaagg agtttgaaag agctacagtc gaggagcaaa tggaacggtt 379921 taaagaaaac ctcctgatgc taatccgcca ttgcacggaa aaagaagaca aggaattcac 379981 accaagcgac ttcagcgccg aagaccttga aatggacgag atgggagata tctttgacat 380041 gcttgaggag aatttaaaat aaaacgcaag ggaattacag aaggcgggag cgaaacatat 380101 gagtcaattt agcaaggatc aggttcaaga tatgtattac ctatcgccga tgcaggaagg 380161 gatgcttttt catgccatcc tgaatcccgg ccaaagcttt taccttgaac aaatcacgat 380221 gaaagtaaaa ggcagcttga atatcaaatg tcttgaagaa agcatgaatg tgatcatgga 380281 ccggtacgat gtatttcgta ccgtgttcat tcacgaaaaa gtaaaaaggc ctgtccaagt 380341 cgtattgaaa aaacggcagt tccatataga agaaatcgat ctgacacact taacgggcag 380401 cgagcaaaca gccaaaatca atgagtacaa agaacaggat aagatcaggg gttttgattt 380461 gacgcgggat attccgatgc gggcagccat tttcaagaaa gctgaagaaa gctttgaatg 380521 ggtgtggagc taccaccaca ttattttgga cggatggtgc ttcggcatcg tcgtacagga 380581 tctatttaag gtatacaatg ctctgcgcga acaaaagccg tacagcctgc cgcccgtcaa 380641 accgtataaa gactacatca agtggcttga aaagcaggat aaacaagcat cactgcgtta 380701 ctggcgcgaa tatttagagg gctttgaagg acaaacgacg tttgcggagc aaagaaagaa 380761 acaaaaggac ggctatgagc cgaaagagct gctcttttca ctgtcggagg cggaaacaaa 380821 ggcctttacc gagcttgcaa aatcgcagca taccactttg agtacggcgc tgcaggcagt 380881 ctggagcgta ttgatcagcc gctatcagca gtctggcgat ttggccttcg gtacagttgt 380941 ttcagggcgt cccgcggaaa tcaaaggcgt tgaacatatg gtcgggctgt ttatcaacgt 381001 tgtcccgaga cgtgtgaagc tgtctgaggg tatcacattt aacggcttgc tcaagcggct 381061 gcaggagcaa tcgctgcagt ccgagccgca tcaatatgtg ccgctttatg acatccaaag 381121 ccaggccgat cagccgaaac tgattgacca catcattgtt tttgagaact atccgcttca 381181 ggatgcgaaa aatgaagaaa gcagtgaaaa cggctttgat atggtggatg ttcatgtttt 381241 tgagaagtcg aattatgatc tcaacctgat ggcttccccg ggagatgaga tgctgattaa 381301 gcttgcctat aatgagaatg tgtttgatga ggcgtttatc ctgcgcttga aatctcagct 381361 tcttacagca attcagcagc tcatccagaa tcctgatcag cctgtcagca cgatcaacct 381421 cgttgacgac agggagagag aatttttgct aaccggctta aacccgccgg ctcaagctca 381481 tgaaacaaag cctctgacgt attggttcaa ggaagcagtg aacgccaatc cggatgcacc 381541 ggcgcttacg tattccggcc agaccctgtc ttatcgcgaa ttagatgagg aagcgaaccg 381601 cattgcacgc cggctgcaaa aacacggtgc gggcaaaggc tctgttgtag cgctgtacac 381661 gaagcgctca cttgaactgg tgatcggcat tctcggtgta ttaaaggcgg gagcagccta 381721 tctgccggtt gatccgaagc tgccagagga ccgaatctcg tatatgctgg ctgacagtgc 381781 ggcagcctgt cttctgacgc atcaggagat gaaagaacaa gcggctgagc tgccgtatac 381841 aggcacaacg ctcttcattg atgatcaaac acggtttgaa gaacaggcaa gcgatcctgc 381901 aaccgcgatt gatcctaatg atccggcata tatcatgtac acgtccggca caaccggaaa 381961 gccaaagggc aatatcacca ctcatgccaa tattcaagga ttggtcaagc atgtagacta 382021 catggcattt tctgatcagg atacgttctt gtctgtttcg aattacgcct ttgatgcatt 382081 tacctttgat ttctatgctt ctatgctgaa tgcggcacgg ctcattatcg cagatgaaca 382141 tacgctgctt gatacagaac ggctcacaga tctgatcctg caagagaatg tcaatgtcat 382201 gtttgcgaca accgcactat ttaatcttct cacagatgcg ggagaggatt ggatgaaggg 382261 gcttcgctgt atattattcg gcggagagcg cgcgtcagtg cctcatgtca gaaaagcgct 382321 gcggatcatg gggccgggca agctgattaa ctgctacggg ccgactgagg gaacagtgtt 382381 tgcgacagct cacgtcgtgc atgatctgcc ggattccatc tcctcattgc cgatcggaaa 382441 gccgatcagc aatgccagtg tttatattct gaatgagcaa agccagctcc agccattcgg 382501 ggcggtcggt gaactgtgca tcagcggaat gggcgtgtca aaagggtatg taaatcgtgc 382561 tgacctcacg aaggaaaagt ttatcgagaa cccgttcaag ccgggagaaa cgctttaccg 382621 tacaggggat ttagcgcgct ggctgccgga tggaacgatt gaatacgccg gccgtattga 382681 cgaccaggtc aaaatacgcg gacaccggat tgagcttgaa gaaatcgaaa agcagctgca 382741 ggaataccca ggtgtgaaag atgcggtcgt tgtggcggac cgccatgagt ctggcgatgc 382801 atcaatcaat gcctaccttg tgaaccgaac gcagctttca gctgaagacg tgaaggcgca 382861 cctgaaaaaa cagcttcctg cttacatggt gccgcaaacc tttaccttct tggatgagct 382921 tcctttaacg acgaacggga aagtcaataa acggctgctc ccaaaacctg atcaggatca 382981 gctggcggaa gaatggattg gaccgcggaa cgagatggaa gaaacaatcg cacaaatatg 383041 gtctgaggtt ctcggcagaa agcaaattgg cattcatgac gatttctttg cgctcggagg 383101 gcattccttg aaggccatga ccgccgcgtc ccgcatcaag aaagagctcg ggattgatct 383161 tccagtgaag cttttgtttg aagcgccgac gatcgccggc atttcagcgt atttgaaaaa 383221 cgggggctct gatggcttgc aggatgtaac gataatgaat caggatcagg agcagatcat 383281 tttcgcattt ccgccggttc tgggctatgg ccttatgtac caaaatctgt ccagccgctt 383341 gccgtcatac aagctatgcg cctttgattt tattgaggag gaagaccggc ttgaccgcta 383401 tgcggatttg atccagaagc tgcagccgga agggccttta acattgtttg gatattcagc 383461 gggatgcagc ctggcgtttg aagctgcgaa aaagcttgag gaacaaggcc gtattgttca 383521 gcggatcatc atggtggatt cctataaaaa acaaggtgtc agtgatctgg acggacgcac 383581 ggttgaaagt gatgtcgaag cgttgatgaa tgtcaatcgg gacaatgaag cgctcaacag 383641 cgaagccgtc aaacacggcc tcaagcaaaa aacacatgcc ttttactcat actacgtcaa 383701 cctgatcagc acaggccagg tgaaagcaga tattgatctg ttgacttccg gcgctgattt 383761 tgacatgccg gaatggcttg catcatggga agaagctaca acaggtgttt accgtgtgaa 383821 aagaggcttc ggaacacacg cagaaatgct gcagggcgaa acgctagata ggaatgcgga 383881 gattttgctc gaatttctta atacacaaac cgtaacggtt tcataaatga agtgatgaaa 383941 ggaggagaca gccaatgagc caactcttca aatcatttga tgcgtcggaa aaaacacagc 384001 tcatctgttt tccgtttgcc ggcggctatt cggcgtcgtt tcgccctctc catgcttttt 384061 tgcaggggga gtgcgagatg ctcgctgccg agccgccggg acacggcacg aatcaaacgt 384121 cagccattga ggatctcgaa gagctgacgg atttgtacaa gcaagaactg aaccttcgcc 384181 ctgatcggcc gtttgtgctg ttcggacaca gtatgggcgg aatgatcacc ttcaggctgg 384241 cgcaaaagct tgagcgtgaa ggcatctttc cgcaggcggt tatcatttct gcaatccagc 384301 cgcctcatat tcagcggaag aaagtgtccc acctgcctga tgatcagttt ctcgatcata 384361 ttatccaatt aggcggaatg cccgcagagc ttgttgaaaa taaggaggtc atgtcctttt 384421 tcctgccttc tttccgatca gattaccggg ctcttgaaca atttgagctt tacgatctgg 384481 cccagatcca gtcgcctgtt catgtcttta acgggcttga tgataaaaaa tgcatacgag 384541 atgcggaagg gtggaagaag tgggcaaaag acatcacatt ccatcaattt gacggcgggc 384601 acatgttcct gctgtcacaa acggaagaag tcgcagaacg gatttttgcg atcttgaatc 384661 agcatccgat cattcaaccg tgatcaaaag cggacagctt cggctgttcc gctttttttg 384721 tgttgaatgc caatttctgc atggtataat agtcgaaata ctcaaataaa ggcaggtcga 384781 aacatgcgca cgtctcccag gatgaaatgg tttgtattgc tgtttacgtt tgttttcgcc 384841 atcggaatga actcattcag aaattccttt caatttttta tgctgccaat ggcagacgcc 384901 ttccatgccg acaggtcgct gatttcggtt tctgtcagca tttttatgat cacaaccggc 384961 atcgtccagt tttttgtcgg tttttttatc gaccgtttca gtgtcagaaa aattatggcg 385021 ctgggagctg tttgcatcag cgcaagcttt ttggtgcttc cttattcacc gaatgttcat 385081 gtgttttccg ccatttacgg tgtgcttggc ggaatcgggt attcctgcgc ggtcggcgtg 385141 acgacccagt atttcatcag ctgttggttt gacacacaca aaggtctggc gcttgctatt 385201 ttgaccaatg ccaactctgc gggcctgctg cttctctcgc ccatttgggc tgcggctccg 385261 tatcatgccg gctggcagag cacctatacc attttgggaa tcgtcatggc ggctgttctg 385321 ctgccgctcc tcgtctttgg gatgaagcac ccgccacatg cgcaagcgga aactgtgaaa 385381 aaatcttatg attggcgagg gttttggaac gtgatgaagc aatcccgcct cattcatatc 385441 ctgtacttcg gcgtgtttac ttgcggattt acaatgggaa ttattgatgc tcacctcgtc 385501 ccgatactga aggatgcgca tgtctctcat gtcaacggaa tgatggccgc gttcggggca 385561 tttatcatca ttggcggatt attggcgggc tggctgtcag atctcctcgg cagcagaagc 385621 gtcatgctat ccatcttatt tttcattcgg ctgctcagcc tcatttgcct gctcattccc 385681 attctcggaa ttcatcacag cgacctttgg tacttcgggt ttatcctgtt attcgggctc 385741 agttacacag gcgtgatccc gctgaccgcg gcgtcaattt cggaaagcta tcaaacagga 385801 ttgatcggat cgctgttagg catcaatttc tttatccatc aggttgccgg agctctcagc 385861 gtgtatgcgg gcggtttgtt ttttgacatg actcatggtt atttactgat tgtcgctgtg 385921 tgcatcgtgt ttgtgggttt atcggctgta atagagctgg tgccgttttt agataaacag 385981 aaggcaaaag aaacccacca ttcaatataa aaggatcagc actgtcaatg ctgatccttt 386041 ttaaatttga gtttttttgt ttcggtattt ttaaggataa tctccttgaa tctgttcatc 386101 tcctcttcgg agtgaaaaaa atgtttgggg atcgcaatat attggccact tgatgtattg 386161 accctgaaga tatttttata ttcgaaaaca gctgtaattt catcccaatt gaaaatgagg 386221 tcatattttt tagaacatat acgaattcct tcttggttca gagtatatgt tcttttggat 386281 ttcatccgtt cgttcttctt gtatgctctg gaaaacttca catatagaag aaggaggagc 386341 agcagtgtaa acagaacgga catcacgata atcaacatac tgttcataaa caagttaagc 386401 gcgtcacttc cataaacgat acggggccat ccgttaatga agttaactgc agcaaatatg 386461 gcgcaaaaca atagaaagta aaagcatgat atttttgcga tttgataaaa aaagatttct 386521 cttacatcct taaaagtgat ttctcctgga agattgatac tttcactagc atattgaatc 386581 atacggtaaa cctacacctc taaccatgtt tttcctttta gtctagcata atttctcatt 386641 tttttgcagg cataccaggg cgctttgttt ttttctccag attgatattg ctccccacca 386701 cgccaatcat aatacaaaca gccccggcaa gatgatacca ggccaggctt tcgttgagaa 386761 tcacaaatcc tgcaatcatc gtcacaatgg tagatacatg attaaaagcg ctcattttaa 386821 acgcctcaat tcgcgacagc gtatagttag acagaaatga agtgacaagt gaagacagca 386881 cgcccaaata cacaatggcg agaacgaagc cgggctcccg gaacggcaga aaataagtgc 386941 cgactgttcc cgccgctccg tgacgcacaa gggcgatggc gttgaagacg acaaagccga 387001 tggctgacat gatgtaggtg agctcggtca gcttgaaccg ctgcgtcatt tttctggcag 387061 cagtattgta catcgctgaa gacaaagcgg acaataggat cagcaaagac ccttttaagc 387121 tggctgattc cacgtcaacg cctttcatca caaaaataaa catgacgccg gcaacggata 387181 aaaccgtgaa ccccttttgc gtccacgttg ggcgttcctt taaaacataa gcggcaaaga 387241 ccatcgtgaa aatcggaatg gctgcctgaa taattcccgc ttcagaggag gacgagtaca 387301 caaggccgaa tgcctgaaag ctgaaaaata acgcgggata cagcagggcg agcggcaaaa 387361 tgtcaatgac gtcctttacg cggattgata gctttaccca gccgaataag atcggtacag 387421 tggccgcagc aaacgcaatg gtgaaccgat gcgccaaaat atcaaacggc tctgctgttt 387481 gcagtgcgat ttttacgaat agaaaggata aaccgataat gaacgaatat aaaatagccg 387541 ctatataagc gggggtttgc tgatgtttaa ccataatggg aagggctcct ttacctgaat 387601 tgcagcgccg gtcgctccct ttattgtatg gccgcggtca gaacggtaca atgagaaaaa 387661 caatgaactg taccggtaca aaacaggggg agaaggcatg gagaaatata tgagtctatt 387721 aacgaggata gaggagatga tgcaaagcac ctcatatcaa gaaggagaca ggcttccatc 387781 tatccgtcag ctgtccgccc gctaccaagt cagcaaaagc acagtgatcc gcgcgctgca 387841 ggagctggaa aagcgccacc ttatctattc tgttccgaaa agcggctatt atattgtgaa 387901 aaagtcaggg aaatcaaaaa gcgggcagcc tggccccatc gactttgcca catctgcgcc 387961 ggatcccgat gtgtttccgt atcttgattt tcagcactgc atcaacaaag cgattgatac 388021 atacaaaaac gatttgttta tttatgggac gccaaagggg cttccatcac tcatccgcgt 388081 actccgaaag ctcttggcca ctcaacaggt atttgcggat gaacggcata ttttcattac 388141 atcaggtgtc cagcaggcgt tatccttgct ttgtgccatg ccgttcccaa atgggaaaga 388201 gaagatcgcc attgaacagc cgggctacca tttgatggtc gaacagcttg agacacttgg 388261 gattcccgcc atcggggtga aacgaacgga agaagggctt gatatagcca aggttgagcg 388321 gttatttcaa acagaatcga ttaaattttt ttatacgatg ccgcgcttcc ataacccgct 388381 tgggtgctca ttgtcagagc gtgataaaca ggagcttgtg agactggcag aagcgtatga 388441 tgtctatctc gttgaggatg attacctcgg tgatctggag gaaaataaaa aggcagatcc 388501 gctgtacgca tatgatctgt cctcacatgt catctatttg aaaagcttct cgaaaatgat 388561 gttccccggc ctccgcgtgg gggcggctgt tttgcccgaa gcgctgactg acacgttcta 388621 tgcgtacaaa aagctgaacg acatcgactg ttcgatgatt tctcaagcgg cattggagat 388681 ttacctgaaa agcggtatgt acggcaggca taaggagaaa atcagagatt cttataaaga 388741 gcggtcgctg aggctacatc aagccattcg aactcacagg cagctgggaa gcggacgctt 388801 tacgttctcc agcgggcagg caccctgtat gcacacccat ctggtgcttc ctcaggatct 388861 gcccgcctca agagtgattc atagactgga aaaacaaggg gttctccttg aggcgataga 388921 ccgtcattat ttatcagatt atccgaaaga aaatctatta aaaatcaata tttccaatgt 388981 gaaaacggaa gatattgagc gcggtgtcaa gctgttgatg agccatttat aaaagctctt 389041 cgtacgagac cattgtgata tcctcgggga aatcagggtg tacggcgcat acagccattt 389101 tgtagccggg atcgacctca tacgttttga tatagcatgg ggaatggctg tccggaagct 389161 caatggatac ttgtccgtcc tggtgcaggc gcactgaaaa ggaatcaagc ggaagcgata 389221 agcctttgcc ttccttgttt gataaagctt tctttcattg accatagatg ataaaaatag 389281 tctgtctgct cgtccttgtc ttttgctaaa aggtcgctgt actctgtttt tgaaaagaag 389341 cgcttggcga tctcaaggct gatcggtttc gttttttcga tatctatgcc gatcggctgt 389401 gaatcaaacg cgcaaatgac ccagcgtccg gagtgagaaa tgttgaaatg agcgtcggga 389461 agatcaggga tgcacggctt cccgtattcc tgcgtgctaa agcggatatc ggatttgtcc 389521 aactgatact gcctgcttat gactgagcga acgagcacat ctcccagcag ggtgcggtga 389581 gcatcttctt tatgataaaa tctccggcat ttctcccgtt tttcaggtga tatgaaagac 389641 atgaaccgtt cattttcttc ctgtgaaagc gggcggtcca tataaattcc gtaaatcttc 389701 attctagatc ctccgtctgc aaaagattgt caaaaccatc ctatcatact tccacaagac 389761 tcatatagag gagaaaataa aaaaacaaag ccaaggcggc tttgttttag tgtacaggcg 389821 gagatgcttt cactgcggct gtccgccttg ccacagcata attcagcaac tggattgact 389881 ggggcaatga aaaacgcaaa ataagtccgg tgaggatggc ggtcaaaatg gtgccaaaac 389941 cgatcggtcc gcccatgccc catgccgcaa acaaaatggt taattccatg ccgttccgca 390001 cccattgcac attccagccg gttttttctg taatcagcat catcagtgaa tcacgcggcc 390061 ccgcgccaag gcctgctgat acataaacac cgacgccgta accaatcagc accacgccta 390121 gagagaagac gatgatcgag cctgtgtagg tcgagagggc aggcagaatg aaattgaaaa 390181 aatctataaa tacaccaatg agcaccatat tcaggagggc accaattttc ggccaagctc 390241 tcgtaaacaa tgacgtgaat ccgacgatga gcgctccaat aatgatggac cactggccga 390301 cggtaagccc gaagtgctga aacaggctgt aatgaaatgc atcccacgga ctaatgccga 390361 gtgcttttcc ttctatcgtc agggatacac caaaagccaa aatgatcaaa ccggcaaaat 390421 aaaatgtcca gcgcagaaca agttcttgct tcacgtgagg tcccttcttt cgtaaaaatc 390481 agtcgattgt cattgtagca catctgacag aagggcggaa taggcgaaag gggctcaaca 390541 aaaaaacagg gccgccggag gcgccctgtt tcagcgtgtt ggcaaaccct tgcattcgtt 390601 gtcaggcctg tgcttcggtg ctcacgaatt taacattagc tgtgctccaa tgctcgccct 390661 tcctagactt caaaggtttt caatcacgct gaaaatcaca aaatcctaaa acgaatatcg 390721 ttttaggatt ttgtcaataa tctgaaacag ggcgctgacg ctctgttttt cttattacag 390781 cgggttcaaa atccggttta agaaccgctg tgtccgttct tcttttggtg cggagaaaat 390841 ttgctccggc ggtccctgct ccacgataac gccgccgtcg atgaagatga cttcatccgc 390901 aacctcctgc gcgaacttga tttcgtgggt cacgacgacc atggtccagc cttcattggc 390961 caagtccttg ataaccttca gcacctctcc gacaagctcg ggatcaagcg ctgaggtcgg 391021 ttcgtcaaac agcatgagct caggctgtat cgccagtgcg cgggcgatgc cgacgcgctg 391081 ctgctggccg ccggaaagct ggaacggata taaatccatt ttgtccttca atccgacttt 391141 atcaagaagc tgaatcgctt cttttctgac ttcctctttg ttccgttttt gcacctgaac 391201 agggccctcc atcacgtttt cgagggctgt gcggtgcggg aacaggtgat acgcctgaaa 391261 caccattccg gattttcggc gaagctttag gatatccgcc tgtttcacct ttttggagaa 391321 atcgatggag aaatcatcaa atgcaagctc tccgcgattc gggatctcca gagcgttcag 391381 gcagcggagc agcgtcgttt tccctgaacc tgaaggccca agtatggcga tgacttttcc 391441 tttttcaatc ttcatatcta tcttttttaa aatttcattt tcaccgaatg atttgtttaa 391501 tcctttaacg gtaagcatac tcggaacctc cttatttggc cacgtagcgg tcaagacgcc 391561 gttcgatgac atgctggacg agtgagagca ggaagcagat aatccaataa ataaaggctg 391621 cttcaatata gatcactaaa atttgatcaa gattccgcgc gccgatttcc tgggcttttc 391681 tgaacagctc agcgaccaga atttgagagg cgagggatgt atctttaatc aggctgataa 391741 aggtattgga taatggcggg atcgacacac gaaacgcctg cggcaaaatg acgcggaaca 391801 gcgttttttg atgtgtcatg ccaattgtgt agccggcttc ccattgccct ttcggcacgg 391861 ataaaataga tgcccgaatg atttcagatg cataggcgcc gacgtttaat gaaaaggcga 391921 taactgcgct tggaaatgga tctaatgtga cgttaaaggc cgggaacaga tagaaaatga 391981 tgaacaattg aacgagaaga ggagtgccgc gtattgcgga tacgtatacg ctgaacaccc 392041 atctcaaagg tctcactttc gacattctgg caagcgccgt aatcagcgcc aggatcattc 392101 cgaatataaa ggaaagaatc gtaaggggaa tcgtatagta gattccccct gaaagtatcg 392161 gccagaatga ctgctgcacc agatcccacg ggatcgccgt gccaagcgtc aatgccggca 392221 gattatttag aaacatcttc gccgaaccat tttttagaaa ttttagaaag agtcccgtcc 392281 tctttcattt cttttaatgc tttgttgact tgatcaacaa cctcgccgct tcctttacgg 392341 aacgtgaaat atgttgactg aggctcacct gtttcaaacg cgattttcac gtttttattg 392401 ccagatgttt ttaagtagtt caatacggca agcttatcgt tgtatgtcat atcgacgcgg 392461 ccttgctgga tcatttgaag ggcctgcgcc atgccttcaa cgccttctac tttagcgccg 392521 gcatttgtag ctaatttgtt gtagttgctt gtcagtgatt gagctgacgt ttttcctttt 392581 acatctgctt cagacttaat atcgttgttg tcttttttcg ttacgacaac ggctcttgat 392641 gttgtgtatt tatctgagaa atcatatttg tcttcacgat ctgtttttcc gacttggttg 392701 gcaacaacgt caaaccgttt ggaattcagg ccggcaaaca tactgtccca ttgtgtttcc 392761 ttaaagtcga ctttaagccc gaggcgtttt gcgacttctg tgataacttc gacatcatag 392821 ccagtcagtt tatcagtgtc tttgtcgtgg taagtgaacg gctcatatgt tccttccgtt 392881 ccgactgtga gcacaccttt tttcttaatt gaagcccaaa gatcgccatc tttggcatta 392941 tcttttgact gattgtcatt tcctgctccg caagctgcaa gagctgcaat acttacgacc 393001 atgaataaag ccaataatgc ttttttcatc ttattcccca cttttctggt tgattttatt 393061 gaaataaaaa attagcttac aaatctaaag gataactttt ttttagtatg agtcaagtat 393121 ttggttttca taagacaaaa tcttttaaaa taaatccaaa aattgctgtg ccggtttagg 393181 caaataactg tccgttctcc acatgacagc cggtgtcata atgaagggat tattttcgat 393241 atggacggtg tgaacgtgat ttctcatatg aacgggaatc attgtgacag gcaaaataga 393301 cgcgccgaat ccggatgaca cgaggctgag caaagttgca gagtcgtggc attcacaaac 393361 aatgcgcggc tccaggttca aacgatgaaa ttcattcatg acctgattat agacgccttt 393421 tccgttgaca ggccgcagca ggatcagcgg aaatgaagga atgtccacca tcttaatggt 393481 gtctccgcac ggatatccgg cttcatctga aagcacgagc acacatggaa tgtcatcaag 393541 ctgcttgaat tgtactgtgt cacttttgat cagtgttgtc gtgaccgccg catcgatttg 393601 ccggctttcc agcagttcca acagtgtcgc gggttcattt tcccaaatat taaaggtgag 393661 atgggggtat ctctctttga tctgtgttac tttttcaagc atcagagccg cgcaataaat 393721 cgttgatccc acggcaagtg taccggctac ttcctccttc agctcctgta cctcaatgac 393781 tgcatcttca aacctatgca gaatctcttt tgctcttttt agaaaaacag ctccttcata 393841 tgtaagagtc atttgttttt tcttgttacg gtcaaacaga acaacaccaa gttcgtcctc 393901 cagctgtttg agctgcctgc ttaaaggcgg ctgcgccatg tgaagctttt tggctgcgga 393961 cgtaattttc tgttcttggg caatggtaat gaagtatcga agctggcgaa tatccaaaag 394021 aaagcgcctc cttatcatac cttttaggta ttaattatag atttaataga tatttttcat 394081 atggatatat caggagtatg attgaaatga aagcagaatt caagcgtaaa ggagggggca 394141 aagtgaaact cgttgtcgga atgacagggg caacaggggc cattttcggg gtcaggctgc 394201 tgcagtggct gaaggccgcc ggagtggaaa cccatctcgt tgtgtctcct tgggcaaacg 394261 tcacgatcaa acacgaaaca ggctatacgt tacaagaagt agaacaactg gccacataca 394321 cttactcaca taaggatcag gcggcagcca tttcaagcgg gtcgtttgat accgatggaa 394381 tgattgttgc gccgtgcagc atgaaatctc tcgcaagcat tcgcacagga atggcggata 394441 atctgctgac acgtgcggcg gatgtcatgc tcaaggagag aaaaaaactc gtcctcttaa 394501 cgagagagac gcctttgaac caaattcatc tcgaaaatat gctagcgctt acgaaaatgg 394561 gcaccatcat tcttcctccg atgccggcat tttataatcg gccgagaagc ttagaggaaa 394621 tggttgacca tattgttttt agaacgttgg accaattcgg cattcggctt cctgaagcga 394681 agcgctggaa tgggattgaa aaacaaaaag gaggagcttg atcatggctt atcaagattt 394741 cagagaattt ctcgctgccc ttgaaaaaga aggacagctg cttacagtga atgaagaggt 394801 aaagccggaa ccggatttag gggcctccgc acgggcagcc agcaatcttg gcgataaaag 394861 ccctgcgctc ttatttaaca acatttacgg ctatcataac gcgcgaattg cgatgaatgt 394921 catcggctct tggccaaacc atgccatgat gctgggcatg ccgaaagaca caccggtaaa 394981 agaacagttt tttgaattcg caaagcgtta tgaccagttt ccgatgccgg tcaaacgtga 395041 ggaaacagcg ccatttcatg aaaatgaaat cacagaagat atcaatttgt tcgatatact 395101 gcctcttttc agaattaacc agggtgatgg aggctactat ttagacaaag catgtgtcat 395161 ttcccgtgat cttgaggacc ctgacaactt cggcaaacaa aatgtcggca tttacagaat 395221 gcaagtcaaa ggaaaagacc gccttggcat tcagcctgtc ccgcagcacg atattgcaat 395281 ccatctgcgc caagctgaag aacgcggcat caaccttccg gtcactattg cgctcggctg 395341 tgagccggtc attacaacgg cggcatcgac tccgcttctc tatgatcaat cagaatacga 395401 aatggcaggt gcgattcaag gcgaaccata tcgcatcgtc aaatcaaagc tgtctgatct 395461 tgatgttccg tggggcgctg aagtggtgct tgaaggtgag attattgccg gagagcgcga 395521 atatgaaggg ccgttcggtg aattcacagg ccattattcc ggcggacgca gcatgccgat 395581 tatcaaaatt aaacgcgtct atcacagaaa caatccgatc tttgaacatt tatacttagg 395641 catgccttgg acagaatgcg attacatgat cggcattaac acatgcgtgc cgctttatca 395701 gcagttaaaa gaagcgtatc cgaacgaaat tgtggcagtg aacgccatgt acacacacgg 395761 tttaatcgcg attgtttcca caaaaacccg ctatggcgga tttgcgaaag cggtcggcat 395821 gcgcgcactc acaacgccgc acggactcgg ctactgcaaa atggtcatag tcgttgatga 395881 ggatgtcgat ccattcaacc ttccgcaggt catgtgggcg ctttcgacca aaatgcatcc 395941 gaaacatgat gcggtcatca ttccggactt atctgtcctg ccgcttgatc cgggatccaa 396001 tccatcagga atcactcaca aaatgattct cgacgccact acaccggttg cgccggaaac 396061 aagaggccat tattcacagc cgcttgattc tccgctaaca acgaaagaat gggaacaaaa 396121 actaatggac ttaatgaata aataaggaaa ggatgttcga aatgcataca tgtcctcgat 396181 gcgactcaaa aaagggagaa gtcatgagca aatcgcctgt agaaggcgca tgggaagttt 396241 atcagtgcca aacatgcttt tttacatgga gatcctgtga accggaaagc attacaaatc 396301 ccgaaaaata caatccagcg tttaaaattg atccaaagga aacagaaaca gcaattgaag 396361 ttccggcggt gccggaacga aaggcttgat ccgcgtgaac tgtatgtcag accgtctctt 396421 tgagctgctt gacgggagct gcctgaatga gaagcagcat gaggccttcg ttctgcaaac 396481 agtatcagag gatggctggc cgcatgccgc tatgatcagt gcaggtgaaa tcatcgcgct 396541 gagccgaact gatatccgaa tcgctctgtg gaaaaacaca atgacttcgg ccaacatcct 396601 tcgcacagga aaagcacagt tcacggcgtg gtggaaggga gcggcctatt atgtaaagct 396661 tgaatgcgcg cctttaccgc ctttgaaaga tgccgaatat gaaagagacc gtttttcctg 396721 ccgcatcgtt tcagtgaaag aggacgttgc gaaatacgct gatttgactt caggtgtccg 396781 tatacagctt cacagccctg aagaggtgct gagcagatgg aaaaagaccc tggaagattt 396841 aaaacggtaa tatcgatagc ctgacgccat gcgtcaggct ttttttatat aatgaaaaca 396901 aaagggggcg tgagaaatgg aacgtgcggg gatctgtcac tcggacggct ttgatttagc 396961 ttatcgaatt gagggcgagg gcgcacccat ccttgtgatc gggagtgcgg tttactatcc 397021 gcgccttttt tcctcagata tcaaacagaa atatcaatgg gtctttgtcg accatagggg 397081 atttgctaag cctaagcggg agcttcgtgc ggaggattcg aggcttgatg ctgtcttggc 397141 tgatatcgaa aggatgagaa catttcttca gcttgaggat gttactatcc tgggacattc 397201 cgggcacgct tttatggctt tagagtatgc caggacatat cccaaacaag ttcggaaggt 397261 ggcgctcttt aatactgcgc ctgataacag tgaagaaaga cagcgaaaaa gcgaatcatt 397321 tttcatggaa acagccagtc ttgagagaaa gaaacgcttt gaaaaagaca tcgagaattt 397381 gccgcaggac atcgacaaag atcctgaaag gcgctttgtg cacatgtgta ttcgcgctga 397441 agcgaaaagc ttttatcaag agcggccgca tgctgctgcc ttatgggacg gtgtattcac 397501 gaatatgccg atcattgatg aattatgggg caatacattt gcccggattg atcttcttca 397561 gcggttagct gatgttcgta tgccggtgta tatcggatta gggagatatg attatttggt 397621 tgcgcccgtt tcgctatggg atgctgttga cggtttatat ccccatgttg ataaggttat 397681 ttttgaaaag agcggccatc agccgatgct ggaagaaccg gaagcctttg atcaaagctt 397741 caggaaatgg cttgatcaat aaaaaacagc ccgcagatca acatccgcgg gctgtttctg 397801 attataagac ccctttcatc gcgcgtttga tcaccggcga gagcagcagg agaatgccgc 397861 caagaacgat agaaatcaaa ccgatggtgc cgaagtacat tgtttcagga attttatcaa 397921 acaatccggc tacttgggca ttgatcgctt gggctgctgc gttcgtcaga aaccacatac 397981 tcattgtctg tgcagagaag gcagctggtg ccagtttcgt tgtcacggat aaaccgactg 398041 gagacaggca cagctctcca agcacgacaa gcaggaagct gagaacgagc caaagcgggc 398101 ttacgagtgc ttcttttcct tgcatagcag ggaataccat aatgataaat gacaatccgg 398161 ctaaaataat tccgattgag aatttaactg gtgtagacgg ctgacgtttg ccaagcttca 398221 tccagagcca tgcgaatatt ggcgcaaaaa tgacaacaaa caatggattt aatgattgga 398281 accatgatga ctgaagttcg aatccgccca atgaaagtct tatgcgttca tcagcgtata 398341 ccgcaagaat ggtcgctccc tgttcctgaa tggcccagaa catgacagca ccgataaaca 398401 aaggaacgta agcggcaaga cgggattttt ctgttttgtc cgcttttttg cttgtaaaca 398461 tgatgatgaa ataaatcaca ggaatcaaaa taccgagaat acttacaagg tcaatgaaac 398521 gtttgatcgt cagcacgcct gtttgtacag agataatcac tgcgatcgcc acaatgataa 398581 caccgattcc ggtgccaatt gcagattttt tagacagcgg attcggcaca ttggaacctg 398641 caagcccgag gtttttcttt cttgtcaaag caaatacgat aagtccgaga agcattccga 398701 ccgcggcagc tccgaatccg agatgatagt tgtacttctg tccgagtgtt ccgacaatta 398761 acggcgcgag taaaccaccg aggttaatcc ccatgtagaa aatactgaaa cctgagtcgc 398821 ggcgcgggtc ttctttcgtg taaagatccc caactacgct tgaaacgttt ggttttaata 398881 agcctgttcc gacaatgata agcaccatac tgatatagaa tgctatcgaa ctgcccggat 398941 aggcgagtgc aatgtggccg aacataatga atatgccgcc gtaaaacacg gtgtttgcgg 399001 taccgaatac ccggtcagcg agccatccgc caataatggt ggacatgtat acgagtgatc 399061 cgtaaatcga cataatggca accgcagtgc ccttgtcaaa gccgagccct ccgtttaccg 399121 tctctgtata caaatagtaa agtaagattg ctctcattcc atagtaagag aaacgctccc 399181 aaaattcggt gaaaaatagt gtaaatagtc ctcgcgggtg accaaagaac cctttttgcg 399241 ggacgctttt aatgatactt tcgttatcaa tcgaagccat gtcagccaaa ccctttctaa 399301 aaaaagtgta ttataaaaat catattctta tataatactt gtgtcaatat aatttatact 399361 catttcaaat agttccatat tggaaaaatt ataaatacct aaaaatagtg atttcctcct 399421 aatttttaaa ctttttatcg tgagattttc ttacacaact attcctttat atttttttaa 399481 taaaatttta gagaaatgta caagcagatc gggcctttgt gagtaacatg atagtaatca 399541 tagagaagga ggctcgcaat tggctgaatt catattaaat gcagcggatt tcggtgttcc 399601 tagagatggt aaaacggatt cgacagaacg gattaatcag tgcctcagta cagctgtttc 399661 gaaaggctat catactgtct ggtttccaaa gggaacatat ttaatagacg caacgcttgg 399721 cggagatctt aatcagaggt ttcgaaacgc ggggatcatt gttcccggca accttgagat 399781 tatgatggac cccgaatgta tcatgaaagt gataccgaat agttcgtggg gttattccgc 399841 attttatgta ggcaagcaag agaatataac tatttccgga ggacaaatta tcggcgaacg 399901 ggatgagcat acgtatgcct cggcggggat aaggtcaacc catgaatggg gctttggcat 399961 atgtattgaa ggatgctcga atgttgtcat tgatgatgtg aaaatttccg attttaccgg 400021 cgatgggatc atagtcagcc caaggggatt aaagaccaat caagattatc gaacgtcaga 400081 gcaaattatc atccgccgct gtgaggttcg gcggtcgagg agaaataaca tttccattac 400141 cggatgtgac atggtcacgg tggaggaatg cttgattgaa gatgccggaa cggggaatgg 400201 aacagcgccg aaattcggaa ttgacattga aggatatggc gaaggtgacg ttgattatga 400261 ggaaccgatt aatgtatcaa ttcgcaataa ccactttgtt ggaaacgttt caagttctgt 400321 gaccaatttt aacgggtatg gcattttaat agaaggaaat cactcagaca atacaatcag 400381 ctacggatat gggacgcaaa cagtgatcaa gggcaatatt ctgagacgcc ctgaagacgc 400441 ggcggctgcg ccaagagtcg ggataaccgg actcggtgta tcacaaggaa aagagaccag 400501 tgatgcagtg atcgctggca acctcattac cggattttca actggaattg atgtcagggg 400561 aaagagcgtt cttgtgacga acaacaaaat cagcaacttt gaaaacacag ggatattggt 400621 ttatcagtcc tccgacgtaa aggtagacgg aaaccaaatt caaaacggac tgtctgaaac 400681 aaggcgcagc atcggtcttc gcgcagtgct gtcagatgac atcgcatttc tgaataactg 400741 tctcattcaa gtcgttgacg gtgtgaacgt ttccggcgga aatatgatca ttaaagataa 400801 tctcctgaga aaattcagcc ggggcatttg gattgctcaa gggaacgcgg tgattgaagg 400861 gaatacactg aatcctgacg cgtttgaagc agtgccggaa tcatattctg tttccgtcac 400921 aaacaatgcc ggcgccatca tcaaaaacaa tacatttaaa gagttcaaaa attaccccat 400981 ttattgctcc acaagtgcaa aaacctcaat tatcggcaac cacttagagc gatccccgct 401041 tttggtcacc atctatatca gcgcaggtgt gcatgagatt tttgataata ccatttcagt 401101 caacagaaca gccgggaatc cgattgtgat ttatctcaat ggctctgcag gctctatcat 401161 ctctggaaac accatcaata acctctccgc gggcactgcg acagctattc aaacaaacac 401221 gtcaaccaat tccaaaatca tcggcaaccg catttttaaa gggaccatca acaaacacag 401281 cagtgataca atagacggca atatgattgt ctgaaaaaag cgcccccctt taggggttct 401341 tttttttcga tttatagatc acgtacattt ctctcacaag tactaacaca aaaaataaaa 401401 gcacgaccca ttccgcaaat gttgtcatct taaagctgga catattgtta taaacggctt 401461 ttgttaaact gaacccttga agcatgtcca tcaacacaga aatagctaat aaacaaatta 401521 atatgaatcc ggtcacgccc aatatcttca tgcttcatca tcctccgctt ttagtgtcta 401581 tctttggcgg agaagttata ccgcatctaa ccctaatgca taatctcaat tttaaaagga 401641 agaatatgag aaaacgacaa ggaaaggtat ttgtgtatgc ctttattttc taagcgaaag 401701 aacaataccg attcaaaaga caagcagaat acagacgaaa ggaatcagga acagcagcaa 401761 gaaaaagaaa ggccggttct catttctcca agtttagcaa agaatatagc ggaaacgaaa 401821 aaggaagtcg gaagcagctc tgacgtcatc attcgcgaga ttaaaatcgg ggagcaggat 401881 catgtccacc tagctgttat ctatatttct gggctggtcg ataataacac gatccatgag 401941 tcgttaattg acccattggt acaggatgag tctatccaga atactcatgc gatccagcaa 402001 attcttgaaa aaacgctccc gctgggcggg gtgaaagcgg aaaagagctg ggacaagctt 402061 ttttccgagt taatgcttgg caatgcgctc atttttgctg atggccatga tgaagctttg 402121 atttgcagca ctcaaggggg agagcagcgc tccatccaag agccgagcac ccaggtgtca 402181 ttccgcggcc cgcgccaagg gtttacagag tctctgcaaa ccaatatttc catgatccgg 402241 cgatacatta aaaatccgaa tttatgggtt gaaaaaatga aaaaaggttc tgttacgaat 402301 acggatatcg ctctcatgta cattcaagga atatgtgatg aaaaggtgct gaaggaagtg 402361 aaacagcgcc tggaaaaaat agatattgac agtattttgg aatctggata tattgagcag 402421 ctgattgaag atgaaacctt tacgacgttt ccgactatgt atcatacaga acgccctgat 402481 gttgtagcgg gtaatctgtt agaaggaaga ttcgcgatta ttgtggacgg aacaccgttt 402541 gtgcttattg ccccagcctt atttgtccag ttttttcagt ctgttgagga ttattattcg 402601 cgttttgaca ttgcgacaag cataagaatt cttcgtgttt tagtcttttt catttcgctt 402661 gtggcaccag ctgtatacgt ggcagccacg acgtttcatc aagaaatgat accgactcag 402721 ctgttagtgg tcattgcggc ccagcgggaa attgtcccgt ttccggctgt tgtggaggcg 402781 ctgacgatgg aggttgcttt tgagattctg agggaagcgg gagtcaggct gccccgggtt 402841 gtcggctcgg cagtgtcaat cgtaggcgcg ctcgtaatcg gccaggctgc cgtacaggct 402901 ggtatcgtct ctccggcaat ggtgattatc gtggcactca ccgcgattgc gagcttcgca 402961 acaccggcgt ttgcaatggc gatttcagcc cggcttattc ggtttatctt tattattgcc 403021 tcagctgtta tgggttttta cgggctgatt ttagggatca ttatgatgtt tgtccactta 403081 tgcagtcttc gttcattcgg cgttccatat atgtcgccgc ttgcaccttt ttcttcacaa 403141 ggcgtaaagg acgcgctttt ccgggttccg tggtgggccg atgaaaaaag gccggaatcg 403201 gtcagcaagg aagataaggt gcggcagggg aaagatcaac gcccagagcc ggccgcttca 403261 cgaggaatgg tgaacaaaga tttggaagaa ggggatcaga atggtacgta aatgtctatt 403321 agccgttctc atgcttttga gcgtcattgt gctgcccggc tgctgggata agcgggagct 403381 gacggatctt gcgattatct cggcgattgg catcgatcgg acaaacgaca gcaactacgt 403441 gctgcatctt caaattatca atccaggaaa tgttgccggc ggccttcagg gaggcggtgc 403501 tggagacagg ccgcctgtat ctgtctattc gattgaaggt aacaatataa cggaagcact 403561 cagaaaagcc tccatgaagg tatcacggcg gctttatttt gcccatacca atctagtcgt 403621 gatcaatgaa aagctggcaa aagaagaagg tttggatttt gtattagata atcttgaccg 403681 ggacacagaa ttcaggacaa cagcaacatt cgtcgttgcc cataaaacaa aagcagaaaa 403741 tattgtgaaa atcttgacgc cgattgataa aattccgtca aataaagtca ataaaacact 403801 cgatttcacg gaggcacaat acgggcgggt ggtcaaaatc aatattcagg acgttttgaa 403861 aacacttgcc gccaacacta tggcaccggt catccccgga tatatgatga ttggtgacga 403921 taaaaaagga gtcagcatgg aaaacacgca ggcgactgac ccgaaagcca ttcttcaggc 403981 agatggtttg gcggtttttg ataaggcagg atatttaaag tattggctgg aagatgatga 404041 aagcgtgggg gcagtctggc ttatgaataa gatccagcat acgtttatta atgctgactg 404101 gggcaagacg aaggatgcgg tcagcttgca ggttacccat caagatacaa agctggtacc 404161 gaaaatgcgg aacggacgcc cgtacatcca tgtgaaagtg tcggttgaag gtattataga 404221 tgctgtcaaa taccctttcc aattgtctga tcccaaggtg ctggccgcta ttgaaaaagc 404281 gctcaacaaa gagcttgaaa aggaaatcag ccatactgtg aaaaagatta agaagaataa 404341 aatagatttt atcggttttg gtgacacgat atatagaaag tatccggagc agtgggagaa 404401 aatgaaggac acttgggaca aagaatattt gccggaactg cccatcgatg tgaaggccga 404461 gacgtatatc agaaggacgg gattgcgaaa caatccgatc aaacaccagt ttaaagatga 404521 ttaggtctga agaaagggga agtgacagat ggaaaaagcc agaataagca taaggcagtt 404581 gtttgtcatg attatcattt ttgaactggg cagctcctta ttgattacac cgggatcaat 404641 ggcgggcagg gatgcttgga tagcagtttt attaggctgt gcgatcggac tgtttctttt 404701 ctatttgtat caaggcattt atcaatgtta tccgaattct tctccgaaag aatatatgga 404761 tgatatgctg ggaaccaagc tgagctggct gttttcattt ctctatatct tgtactttgc 404821 ctatattgcc gcaagggtgc tgcgtgactt tggagaaatg ctgctgacgt ttgcttatca 404881 tgatacacct atcattattg taaatgcttt attaatggta gtaagcatat atgccgtaag 404941 aaaaggaatt gaagtactcg cacgcgcggc cgaacttctt ttcggggcca tgtatttact 405001 gggcgcgatc ggccttgtgc tgattattgt ctcagggact atagacccgc acaatttaaa 405061 gccggttttg gcaaacggca tttctcctgt ccttcactct gttttcacac agaccatgta 405121 cgttccattt ggtgaagttg ttttatttgt gatgattttc cctaacctga atgacagaaa 405181 agatgtgaaa aaaatgggga tgatcgccat ggctattagc ggattgattg tggcgctcac 405241 cgtggcgatt aatattagcg tgcttgatgt tgatcttaca ctcagatccc agtttccgct 405301 tttaagcacg atccagacaa tcaaggtcga agaattttta gaccggctcg atgtcttttt 405361 tatgctggcg ctgatcatcg gcggcttctt taaggtcagc ctctacttat atgccactgt 405421 ggttgggaca tctacgctct ttaaggaaaa gaacccctct caattggctt atccgatggg 405481 attgggcatc ttaatccttt ctataacgat cgcgactaac ttttcggagc acttgaatga 405541 aggcctgaac gtggtgccgc tgtatattca tttgcctttt caattattgt ttccgctctt 405601 tctgtttatt gtggccgttt ggaaaaagaa acgaagagag aagtcaaaag gggaggaagc 405661 aaaaaaatga taaaaagagc ggggggatgc ggccgccgct ctttttatgt tcacttctat 405721 ataaaagggg gatatagggt gcgcccctgt ctgcactggc agaggcgcgt tttgttatac 405781 gactgcgacg ttttccttca cagtaaaact tcctcttgaa agtctgatat tgatgtctga 405841 cacttttgca atttgttcat cgtgcgtcac cataatgacg catttatctt ccttgtgcgc 405901 cagatcctga aagagccgta cgatctcttt tgatgtgtcc tcatcaaggt ttccggtcgg 405961 ttcatcggct acgataagat ccgtgtcaca gcagaaagcc cttgtaattg atacccgctg 406021 ctgctgtccg ccgctcagtg tgagcacttt ttgccgggct tgtttttcgt tgatgccaac 406081 cttctgcagc atgtcaagcg catatgattc tttgttcttt tctttagaac ctgtgatttc 406141 catagcggtt gtgacgttct gcaaagccgt catatacggg agcaggttgt acgcctgaaa 406201 gacgattgat acatattgat ttctgaaatt ggttaagccg attttagaaa ccgcttttcc 406261 gtcgtaaagg atgtttcctt cttttggtgc gtcaagtccg cctgccagag acaggaaagt 406321 ggttttcccc gtccctgatg ttccgacgat tgtgtagaat tttccttttt gaaagctgat 406381 gttaatatcc tgaaacaatg gctggctttt gtttttatac cagtagccga cttgttgaaa 406441 ttgtaataag ctcataggtt ccgcctcttt ctattcctgt tttgtcaata tcgttttcgg 406501 atgaagccgc agtactgaaa ttgacggcag caatgttgca atgattgcga ttaggatgcc 406561 gatcccgcca agtataagca tgtcgttcat agaaaccgcg acgttcagtg aatcgataac 406621 gtccacgttg gatgaactgt ggccgaacat tttgccgccc atgccgccac cgccgccggg 406681 catttgtccg cttgcggttt gcgttgaatc ggttgatgaa ctgatttgct gggataaaag 406741 ctgatttcca agctgattcg cgacgagatt tcccgtcaca gatgcaaggc cgatagcgat 406801 aacggccaca atcagaatct cagtcaagaa ctgtccaatc aatttccatc gtttttcacc 406861 gatggccatt aacacgccca tttcgtattt gcgctccctg attgacatca tgacaatcag 406921 gccaagaatg acggcgcctg ccactgatac aagatacacc acgtttttag agaaagaagc 406981 cacattttca atcggtccga ccatttgctg gtaaagctga tcgtttgtat tcagtgtgta 407041 cgtatcaaag tcaattgatg ttttcttcgc tgcttttacg aaagtatcca tatttttcgc 407101 gtcgtccata tagtaaacag ctgagtcaat cgtattttta tagtcgtcgc ctttcaatgc 407161 cgctgttgct gtgtaaggcg tataaagctt gttataagga tttaagaaag agaaattttg 407221 ggcttggtca tcacctgaag atgttgtttt ataaataccg acgatcttca gttttactgt 407281 tgtatcctca tccgttgctg attcaattgt gatcgaatcg ccaacgctta aatcattttc 407341 ttccgctaat gtttcgttga tcactgttac ttttttgccg acatctgatt ttgtaatcgc 407401 gcgtccgtct gtgatttttg aatctccgtc agagaaatca tcgactaacg ctgtgctgat 407461 gacaccttca atagaaagat cagcttgaac catttgcggt ccgccttgtc ctccgccttg 407521 actgttttta gcgtttgagc ttgaactgct ggagctggaa tcacttgaac tagagctttc 407581 aatcgcatca aagtttcccg cgttggctga agctgatgtg gtgtaattgt agctcttcac 407641 atgatcaagc gctgcaagct tattcgcatc agacactttg atcggtgtgg attcgaagct 407701 gcgcttttca ccgctgtcct gctgtttttc catttgcttt tggcggtcaa cctgaagtgt 407761 cacgcttcca ccgagttcct gtctggccag ttcgcttgac ttttgtgctg ccgactggat 407821 ggcgaggcct gatagaacaa agacacatat gactgtaaac acaaataatt gcaataacgt 407881 ttttcccttt ttagccttca tattccaaaa ggcccgtttg ataaagttca tttatgttcc 407941 tccgtatagg tatttttatt gataagaccg cctctggggc gcgtcccctt gctgataaat 408001 taatagtagt ccaaaggtat gaaaaaaata tgaacaatct atttctagtt gatgaaataa 408061 aaactaacaa ttgtgaaacg caaaaccttc tgtttaaaat ggtgctatta tataaaaaag 408121 catcaaaaca accggaggat ataatgaaaa tattaatgat agaagataat gttagtgtat 408181 gtacgatgac ggagatgttc ttttttaaag aaggttttga agccgaattc gttcatgacg 408241 ggttagaagg gtaccagcgt tttacggaag aaaattggga tctaatcatt ttggatatca 408301 tgcttccatc tatggacggc gtgaccatct gcagaaaaat aagagagaca agcacggtgc 408361 cgattatcat gctgactgcc aaagacactg aatcagatca ggtcatcggt tttgagatgg 408421 gggcggacga ttatgtcaca aagccgttca gcccgctgac attggttgcc cgcatcaaag 408481 ccgtcatcag aagatataag gcgacaggca aagcggttat tgatgaagat atgattgaaa 408541 cggaatgctt taccattaat aagaagacga gagaagtatt attaaacgga gagcctgtag 408601 aaaatctcac gccgaaggaa ttcgatctgc tttattacct tgtccaaaat ccgcggcagg 408661 tgttctccag agaacagctg cttgagcagg tatggggcta tcaattttat ggagatgagc 408721 gaacggttga cgttcatatc aaacggctgc ggaaaaagct tgccagcgag gacaagcctt 408781 tcctgtatac tgtgtgggga gtagggtata aatttgatga agattaaata tttatatcag 408841 ctgctgctaa gccatatcag cattttgatt ttagcgtttg tcattatcat ttctctgttt 408901 tcccactttg tgaaggaatt tgcctatcag aacaaagtag aggaattgac gtcatatgcg 408961 gtgcagattg caaatgaatt ccaatccggc caggtggaca tgcgcaggct ctatccttat 409021 caggacattt taagcacaag aaagacgcaa tttatcatct ttaatgaaga gcagcagcct 409081 tattttcttc ctgaaggctt tcatcaccca ccaagggaac agctgaagaa atcagaatgg 409141 aataagctga aaaaagggca gactgtcacg atcagggcag atggccgttt tgatgatgaa 409201 gtgtcccttg tggcgcagcc tatatttgtt cagaacgaat ttaaaggcgc cgttctgctg 409261 atttctccga tcagcggtgt tgaacagatg gtcaatcagg tcaacctcta tatgttttac 409321 gctgtgatca gcacgcttgt gattacgatt cttgtgagct ggcttctgtc caaattccat 409381 gtcaagcgga ttcaaaagct gagagaagcg acagataaag tggcttccgg cgattatgac 409441 atccatttgg aaaacagcta cggggacgaa atcggcgtac tggcgtctga ctttaatatc 409501 atggcgaaaa aactaaagca gtcaagggat gaaatcgagc gccttgagaa gcggagaagg 409561 cagtttatcg ctgacgtgtc acatgaatta aaaacaccgc tgacgacgat caacggtttg 409621 gttgaagggt tgaacagcca tacgattcct gaggataaaa aggataaatg cttctcgctg 409681 atcagtgagg aaacgaagcg catgctgcgg ctcgtaaaag aaaatctgga ttatgaaaaa 409741 atcagatccc agcaaattac cttgaacaag ctagacgttc ctctgatcga ggtgtttgaa 409801 atcgtgaaag agcacttgca gcagcaggcg gaagaaaaac aaaacaagct gatgatccaa 409861 gtagaggatc acgtcatcgt acatgccgat tatgaccggt tcattcaaat tctcgtcaac 409921 attacgaaaa acagcatcca atttacgcaa aacggtgaca tttggctgcg cggaatggaa 409981 ggttataaag agacgattat tgaaattgaa gacacgggta tcggcattcc aaaagaggat 410041 attgagcata tttgggagcg attctataaa gcagatattt caagaacgaa cacagcatac 410101 ggtgaatacg gactcggtct ctcgatcgtc aggcagctcg ttgaaatgca ccagggcaca 410161 gtagaaatca agagtgaaga agggaaaggc acaaagttca tcatccgcct tcctttaacg 410221 gcaaaacagc aatagcatac agggcggcgc atcaactgat gcatccgcct tttttgcaca 410281 ccgcttcggt ttattgcgtg ctcccgaaaa caaagattgc gtgtttttcg ggttgggacg 410341 gcctataaac atgataaaat atgacataaa cagtttttga tgggagaggg tgaaggaatg 410401 aagagtgggg taattccttc ttcagcggtc ggtcaaaaaa ttaacgagtg gtacagatat 410461 atccggacat tcagcgtgcc ggatgccgaa gtgttaaaag ctgaaatcca gcaggaactg 410521 aaacacatgc agcatgattc caacttgctg ctttattatt cactaatgga attccggcac 410581 cagcttatgc tggattatct tgagccgtta gagaaattaa atatcgaaga ccagccaagc 410641 ctgtctgaat tatcaagaaa cattgacagc aaccaggcag atctcaaagg gctgctcgac 410701 tattacgtga atttttttcg cgggatgtat gaatttgata agcgggaatt tatttctgcc 410761 attacatact ataaacaggc ggagaaaaag ctctcctttg tcgcagacca tattgaacgg 410821 gctgaattct attttaaaat cgcggaagct tattattata tgaagcaaac gtatttttca 410881 ttgattaata taaaaaacgc ctatgaaatt tacgtggagc aggaaaccta taatgtgaga 410941 atcattcagt gccatttcgt cttcggggtc aacctgatgg atgaaagaaa tttcgaacaa 411001 gccgcacgcc atttcaaatt ggcgctcaac atggcccaag cagaacaaaa agcccagctg 411061 gttggaagag catactacaa tctcgggtta tgctattaca atcaagacct tctagaccct 411121 gccattgatt actttgaaaa agcggtctcc acatttgaaa gcagcaggat cgtcaattct 411181 ctcccgcaag cctatttttt aatcaccctg atttattata aacagggaaa acatgataaa 411241 gcttcggaat atcacaagcg gggctatgaa tatgctaaag aaacagacga tgcagactat 411301 gccgtaaaat tcgagttttt gcaatcccta tatctggatc agcccaatga agaaggaatc 411361 gaacgatgtt tccagtactt aaaaaataaa aatatgtacg ctgatataga ggatttagcc 411421 ctagaagtag caaaatatta ctatgaacag aaatggttta aactgtctgc ttcctacttt 411481 ctacaagttg aagaggcaag aaaacaaata caaaggagtg aaggtttgta tgaaattgaa 411541 atctaagttg tttgttattt gtttggccgc agccgcgatt tttacagcgg ctggcgtttc 411601 tgctaatgcg gaagcactcg actttcatgt gacagaaaga ggaatgacgt aagaacaagc 411661 cccttctcat tagcgagaag gggtttttct tttcaaaaaa acaccgcaag acatagtctt 411721 gcggtgccgc cttcatggag attacgttta tttagtagcc tcctacaaat gcagttccca 411781 caatgatcaa gaggataaat aacacaacaa tcaaagcgaa agaagttccg taacctgaca 411841 ttttgtgcac ctccttgcga gattgcttca gcaaatgctg caaaactgtg gcggacaggg 411901 tcccgcagag acggtcagca gcttagaagc cgccaacaaa cgcagtccct acgataatta 411961 atagaataaa caatacaacg attaaagcga aagaactgat gccgccgtaa ccgccgccgt 412021 tagagtatcc tgacataagg tttcacctcc ctatgaagga tactataaga tatgctgaac 412081 cgatccattt ggcagggata atagtggaca agagaaaaaa tgaagaattc ggctatatga 412141 aggtgatata aaaaaatagc gggcgctgcc gcccgctatt tatgtacgat taagagatca 412201 gcacgcccgc gaaaaattcc tggtataacg cttgaacggc ttttctttct tcggcttctt 412261 ttacgccaaa catcatgctc acttcagaag acccctgatt gatcatttcg atattcacct 412321 gtgcctctga taatgctttg gcggctcttg ccgttgtacc gacattgtgg cgcatcgctt 412381 cccctacaac cataatcagg gcgagatgat gctcgacgat gacttcatcg gcatgcaaat 412441 cctcttcgat ccgtttgatg acgctgcgtt cagtggcggc atccatttgc ccctgccgta 412501 aaatgattgt catgtcatcg attcccgatg gaacatgctc atacgtcaaa ccatgctcct 412561 ccaggatttg aagggctctg cggccaaaac cgatttctct gttcatgaga tacttgctga 412621 tataaatgct gcaaaaaccg gtgtcgctgg caatgccgac gacaggcccg tttgtgttat 412681 cccgcttgct gacgacgcgg gtgccttcgg ctgaggggtt gttcgtattt ttgatctgaa 412741 caggaatccc cgctctgaat gccggaatga gcgcttcatc atgaaacact gaaaaacccg 412801 cgtaggacag ctcccgcatc tctctatatg tcagctcgct gatttccttt ggattctcaa 412861 cgaaggacgg attgacagaa tacacagcgt ctacgtctgt aaagttttcg tacaaatcgg 412921 cttgtagtcc gttggcaaga atcgaaccgg taatatcaga accgctccgt gagaatgtga 412981 tcacatcgcc atccttgctg aatccgaaaa aaccgggaaa aatgatgagt ccgtcacgtt 413041 cccgaagacg atagaggttt tgataggatt caggaagaac ttgcgcgttg ccgggttcat 413101 ttgtcacaaa gaggccggca tccttcgggt ttacatattc cgctttgacg cctttataac 413161 ggaagtaagc ggcgatcagt ttggcattgt tatcctctcc gctggccttg actgcgtcaa 413221 ggtattgttc gggattgctt ttgtctcctt ctaaaagcgt aaacagatca tctctgattt 413281 tttcgataat gctttgcccc agctgaagct cattggcgat gagagcgtac cgttccacaa 413341 cagcttccgc cagttcaggt gcgctgcctg ttgccaaata ttgttctgca catgcgatta 413401 agagatcagt cactttcgta tcctcggcat agtgttttcc cggagctgaa acgactacag 413461 ctttccgtgc cggatctgag gtaacgatgt gaaacacctt gtcaagctgg gcgcctgaag 413521 caagtgagct gcctccgaat ttaacgacct tcatgtttac atctcctaat gtttaaaatt 413581 ttcacacaaa tttagtattt attatctctc tttcagtact gtaaatcaag ggggaatttc 413641 tttctcagga gaacatttgt atttttcacg aggaataatg ttaggtttgc tgaccgtatg 413701 cctgcgttat aaagataaat atggtaaaca gcctaacgtt ttgggatgga aaatggttag 413761 aatgattagt aaaattgata aatgactagg ttaatatttt taaagaatat tgactaaccc 413821 tataaaaatg gtaatatgta aatgataatg ataatcaatt actatatggc catattgttt 413881 tgagtccttg cggagtagga gatacgttct ttttgctgta aggatgtaag gaggcagcat 413941 gaagctacgt tacttattta ttctacttat catattagca gtcacatctg tatttatcgg 414001 tgtagaagat ctgtcgccgc ttgatctctt cgatttaagc aaacaagagg cgtcaacgct 414061 gtttgcaagc cgtttgccgc gattgatcag cattgtcatt gcgggattaa gcatgagcat 414121 ctgcggtttg attatgcagc agatcagcag aaataaattc gtgtcaccga cgacggcggg 414181 cacgatggat tgggcgaggc tcggcatttt aatttccttg ctgctgttta catccgccag 414241 tcctttaatc aaaatgctgg tcgcgtttgt ctttgccctt gcaggaaatt ttctgtttat 414301 gaaaatcctt gaaagaatca agtttaacga caccatcttt attccgcttg tcggtttaat 414361 gctcgggaat atcgtcagtt caatcgcgac atttatcgca tataaatatg acttgatcca 414421 gaatgtgtca tcatggctgc agggagactt ctctttagtc gtgaaaggaa gatacgagct 414481 tctttatctg agtattccgc tcgtcatcat tgcctatgtg tatgcggata aattcacatt 414541 ggccggtatg ggtgaaagct tttctgtcaa cctcggcctc aagtataaac gggttgtgaa 414601 catcgggctc attatcgtgt ccctgatcac gtctcttgtc attttgactg tcggtatgct 414661 gccgtttctc ggtttaatca tcccgaatat tgtatcgatt tacagaggag acaatctgaa 414721 gagcagcctg ccgcatactg tgctgttggg agcggttttt gtgctgtttt gcgatatact 414781 gggcagaatc attatcttcc cttatgaaat ctcgattggc ctgatggtcg gaatcatcgg 414841 cagcggcatt ttcctgttta tgctgttaag gagaaaagcc tatgcgtaac cagatgaaaa 414901 tagctttgct cgttggttta gccattgtat gtattggctt gtttttgttt tatgacttag 414961 gcaattggga ttacaccctg ccgagacgaa tcaaaaaagt cgctgccatt gtgctgactg 415021 ggggagcgat tgcgttttcg accatgatct ttcaaacgat tacgaacaac cgcatcctga 415081 cgccgagcat tttgggcctt gattctctct acatgctgat tcagactggc attatctttt 415141 tgttcggttc tgcgaatatg gtcatcatga ataaaaacat caactttatc atctctgttc 415201 tgctgatgat cctgttttct cttgttttgt atcagatcat gttcaagggt gaggggagaa 415261 atatcttttt ccttctgctt atcggaatcg tgtttggcac gctgttcagc agcctgtctt 415321 cttttatgca gatgctgatt gatccgaacg agttccaagt tgtgcaggac aagatgtttg 415381 ccagctttaa caatatcaat acggatttgt tatggctcgc gttcatcatc ttcctgctga 415441 caggcgttta tgtctggcgt tttacaaaat ttttcgatgt gctgtcgctc ggacgcgagc 415501 acgccgtgaa tttgggcatt gactacgaca aagtggtgaa gcagatgctg atcgtggttg 415561 cgattttggt ttctgtttca acagcgctag tcgggccgat tatgttttta ggccttctgg 415621 tcgtcaacct ggcgagagaa ttcctgaaaa catataagca ttcatactta atcgcaggct 415681 ccgttttcat cagcatcatt gcgctggtcg gagggcagtt tgtggttgag aaagtgttta 415741 ccttctcaac gacgctgagc gtcattatta attttgccgg cgggatttat tttatctact 415801 tgctgttaaa ggagaataaa tcatggtaga ggtcagaaat gtaagcaaac aatatggcgg 415861 gaaagttgtt cttgaagaga cgtcagtcac gattcaaaag ggcaaaatca cctcgtttat 415921 cggtcctaac ggcgccggca aaagtacgct gctgtctatc atgagccgcc tgatcaaaaa 415981 ggattccggc gagatttaca tagacggaca agagattgga gcatgtgaca gcaaagagct 416041 tgccaagaaa atgagcattt tgaagcaggc gaaccaaatc aatatcaggc tcacgatcaa 416101 agacctcgtc agttttggca ggtttccgta ctcacagggc cggctgacag aggaagactg 416161 ggttcatatc aaccaggcgc ttagctatat gaagctggaa gacattcaag acaaatactt 416221 ggatcagctg agcggcggac agtgccaaag ggcatttatc gccatggtca ttgcccagga 416281 cacagattat atctttctgg atgaaccgct gaacaatctg gatatgaaac actcagttga 416341 aattatgaaa ctgctgaaac ggctggtaga ggagcttgga aaaacgatcg tgatcgtcat 416401 tcacgatatc aattttgctt cagtctattc tgactatatc gtcgctttga aaaacggccg 416461 aatcgttaaa gaaggaccgc ctgaagaaat gatagaaaca tcagtgcttg aggaaatcta 416521 cgatatgacc atcccgattc agacgattga taatcaaaga ataggtgttt atttttctta 416581 atatatagaa gaggtgagga gcatgaaaaa gttcgcgtta ctattcatcg ctttggtcac 416641 tgccgttgtc atttctgcat gcggaaacca aagcacaagc agcaaaggtt ctgatacaaa 416701 gaaagaacaa atcacagtga aacaccagct cgacaaaaac ggcacaaaag taccgaagaa 416761 ccctaaaaaa gttgtcgtat ttgactttgg aagcttagat acattagata aactaggact 416821 tgatgatata gtagcgggcc tgccgaaaca agtccttcct aaatatctgt ccaaattcaa 416881 ggatgacaaa tacgctgatg tcggcagctt aaaagagcca gacttcgaca aagtggcaga 416941 attagatcct gatctgatca ttatttcagc aagacaatct gagtcttaca aagaattctc 417001 taaaattgcg ccgacgattt accttggtgt agatacagcg aagtacatgg aatcatttaa 417061 atcagacgct gaaacaatcg gtaaaatctt tgataaagaa gacaaagtga aagatgagct 417121 cgcaaacatt gatcactcaa tcgcagatgt aaagaaaacc gctgaaaagc ttaacaaaaa 417181 cggtctcgtc atcatggcga acgatggaaa aatcagcgcg ttcggcccta aatcaagata 417241 cggcctgatc catgacgtat tcggcgtggc tccggctgat caaaacatca aagcgtctac 417301 gcacggacaa agtgtttctt acgagtacat ttcaaaaaca aaccctgatt acttgtttgt 417361 tattgaccgc ggtacagcaa tcggagaaac atcatctaca aaacaagtcg tggaaaacga 417421 ttatgtgaaa aacgtaaacg cagtgaaaaa tggtcatgtc atctaccttg attctgctac 417481 ttggtattta tcaggaggcg gacttgagtc tatgacgcaa atgattaaag aagtgaaaga 417541 cggtttagaa aagtaaaacc aaaaagagcc tccgctaaat agcggggctc tttttttgtt 417601 aatcagcgtg ccggctgctg ttcggcaggg cgctgaggtt tctttaatgt gaatgagaga 417661 aggaagccga caagtgcaat gacggcagcc actataaaag cggcgttcat gccgtgcagg 417721 gcggcgtgct tcacatttgt cgtgcctgca tgtgccgcct ggttgctcat cacggaaacc 417781 aatagtgcgg ttccgatcga gccgccgact tggcgaatcg tgttgttcat cgcagttccg 417841 tgcggaatca agtggcgcgg cagcgcattg attccggctg ttgtcaccgg catcatgatc 417901 atggcggtgc ctaagagacg aacggtgtat aaaacgacaa tccaagcgag tgacgtatgg 417961 tcagtcagct gcataaacgg cagagatgtc aggaagatga tgcagaaacc ggcaatcgcc 418021 agccctcttc cgccgacacg gtcaaaaatt ctgccgataa tcggcgacat aaagcccatc 418081 acaacggctc ccggcaggag cataagccct gtatcaaaag ctgtgacgtc tctgacattt 418141 tgtgtataaa gcggcaggat ggtttccgta ccgatcaata atgcaaagac gagggttccc 418201 agcagtgttg ttaagctgaa aacgccaaac gtgaagacgc ggaattccag catcggtttt 418261 ttaagcttca tttgtcttgt gataaacaag agcagcgcga tgacacccac cagcagtgaa 418321 atcaagacgg ttgaactgga ccagccataa gagccgacgc ttgagaagcc gtacagaagg 418381 ccgccgaacc caaatgttga aaggatgact gataaaatat caatctgtgt ttttcttaaa 418441 gtcgtcacgt ttttcatcag gatgctggca agaatcaaat caatcacagc aaacggaaga 418501 ataatataaa acaatgatct ccaagagaaa gcttcgacag cccatccgga aagagtcggt 418561 ccgatcgcag gcgcgaatga gatgaccaat ccgaccatac ccatagcctg gccgcgcttt 418621 tcaatcggaa agattgtcag gaatacagtc tgcatgagcg gcatcataat gccggctcca 418681 gccgcttgaa tgatacgcgc tgtcagcaga accgggaagt tcggcgcgaa cgctccgacg 418741 actgttccgg cagtgaaaat gctcattgct gtgatgagca gcgcccggct tgtgaatttc 418801 tcaattaaaa acgcggtaat cggaattaaa atcccgttgg ttaacataaa tgatgttgtc 418861 agccattgtg cttggttggc atcgacattg aaatccctca tgatatgggg aagtgcagta 418921 atcaacaatg tctggttcaa aatcgccaca aacgctccgg ctaacaaaat gccgacaatg 418981 acagaacggt taaaaggttt ttgttcaata cttgtgttca atacatatcc cttcttttct 419041 ctaagtaatt aacagtgttt ttaacatgga aacgggctgt gttaaaacac cggtttgttc 419101 cagatagcca atcagtgatt tgagtaaaaa agcgcggggt tcttccttct tcgcttcttc 419161 ctccagcata gcggctgcgg atgtcagttc atctacgtca tagtccgcgg cggacaggga 419221 agagatgcct ttatgtaatt ccttcaggct ttccgataat aggactgatt tatcctttgg 419281 cttgtaggag gatgctgaat gaatataaag ctcgatggct tcgggcggaa gaagagactg 419341 gcgggtttcc ctgtttttga taatctgatt gagggtgctg atgataaact ctgcgatcgg 419401 gtcaagctca agcggttttt cctcgatttt gatcagcatt aaaaactcac gcatcatgcc 419461 gtgaagaatg ataaccaaat cccacacaaa cgggagaatg gtttctccat acgcctggat 419521 cagcgaatcg cggtgccagc agataatcgt cgatctggtc tgatggatat gctgtttgac 419581 ccggtcattg tgcagcttgg ggtttccgta ggtcagcata ttgaaaaact gctgattccg 419641 cctgaagccc tccagttcca ttttgacctt ttgcgtcaaa cgctcctccg gtgtaagtgc 419701 tgtattttcc tgaagtcttg aggccgcggc caccatttgc ttctggttaa atgacagcag 419761 ctccaaaagc agatcttctt tagattggaa cagcttatat atcgaagctt ttgacatctt 419821 acattcttct gcgatcgcct gcatggaaac cgacgtaaaa tccttttccg aaaaaagctt 419881 tcgcgcggct aacaagatat ctgttttttt atcaagcatc tcatggcttc cttctttctt 419941 gaacattaga aaacccattg gttcacagaa aaccaatgag taacaatgaa aaaattttac 420001 cagataaaca aaatagaagt caatggattt taaccgggta aatgaaaggc ctgccggaaa 420061 atccgacagg ccgaataaga gcttattttt caactttaaa tccttgtttt tcaagcattt 420121 cacggatgtg cggatagtac aggcgctcat agtaggaagc gatgctctgt gaccagtttc 420181 ttgtttcttt tccgtttgtc cgtttattca tgtattcaga catctgttcg tcgtatgcct 420241 gaatgtgaga cgtcagctca tcctgattca aataagtttc ctgatgattg acagcttcct 420301 gcggcaagcg cggttttttc gctgaacggt cggcaggatg cccaatgaca aggccggata 420361 aagggaacac gtatttcgga agctcaagca gttcgatcag ctcttgaggg tttccgcgaa 420421 ctgcaccgat cggaactgtg ccaagtccga gtgactcagc cgctgctgtt gctgtgccga 420481 gggcaatacc agcgtctact gcgccgacaa gaacagattc caatccattt gtgatttcca 420541 ttttgaaatc atgcagatct tcaagcgcaa ttttggcccg gttaaaatct gcgcagaaca 420601 gcaggaaaac aggagcttga tcgatccatg gctggccgcc tgccagctcg gagattttct 420661 ttttgcgctc tttatcctgg actgtgatca cagtcacttg ctgtccgttg atagaagaag 420721 gggctgattg caccgcttca atgatttggt ccaattgctc ctgagctaca ggctcatctg 420781 tgtagctgcg aatcgagcgg tggtctgtta aagatttaat cacttcattc atatgagaca 420841 cccttccttt actcgctaag ctctgtgcgg acaacatcaa gaggagcgct cagcagttct 420901 tttccttttg cgacaaaccc ttggaaatgc gcagtttcgt tatggaattt cattgccgct 420961 tcatctttcc atttttcaag catgacaaat gtattttctt cgcctacttt ttcgaatagg 421021 tcgtattgcg cgttgccttc ctcagctctt gaatgctgaa caagtgattg agcctcgctc 421081 aaaaattcct cgcgtttttc tggttttact ttgatgtaag cttgtaatac gatcatgtaa 421141 atctcctccg tcgttatgcg aatttattgt tcgaatttca tcgaactaaa tgtaacatgt 421201 attctaaatg aggtaaagga aaaaccctta tatagtaaaa ttgtcattct aattgttgta 421261 tgatacattt gtgtcatgaa cattccaaac catccagaaa cagaaacatt gcagctgaca 421321 aaggttcttc atgcacttag tgatccgctt cgtttagagc tcgtcaagca attagctgaa 421381 gcaaaagaaa aaacgtgcag cacctgtgca gatgtgcagg ttgccaaatc gactttgtcg 421441 catcatttta aagttttgag agaatcaggc atcgctcaag ttcggataga aggaaagcgc 421501 cggtattatt cgcttcgcgc tgaagacctt gaaaaggcat ttccgggact gcttgaagcc 421561 gtgctgaatg tagaccagga ccgctggtga atcaatcccc tgtaacgggg atttttttat 421621 gtccgtaaac cgctttgaaa agccgctgca caccctcctg aatatcttct tccttcagcc 421681 gtgcaaagcc gataatgaga gcaggcctgc ccgtttgccg cttgttttcc ttcaagttaa 421741 atcggctcat tccgaatatt tcaagctgca gcccggcagc atgtgacagg atgtcttgtt 421801 cggtgcgcct ggtatcaaat tcggtaacaa aatgcagccc cgcatttgcc ccttttacgg 421861 taacctctcc gctgaactct gcttctaaag cggtgatcag gcgttctctc ttttctttat 421921 aatgctgctt catttttttt atatgcttct gatattcacc agactcgata aattcctgca 421981 gggtgagctg tgtgagtgat gagcaagtct gcagatcata gccccgctgt ttgtatgccc 422041 tcaacagctc aggcggcaac accatatagc tgatccgtaa gccggggaga agggactttg 422101 aaaaggttcc catatagatg acattttgaa aacggtcgag gctttgcagc gccggaatac 422161 tgtctacatc atatgtgaat tcactatcat aatcgtcctc aatgatatat cggcgcggct 422221 cctcggctgc ccagttcagc agctgaattc ttctggatac aggcataatc gttccggacg 422281 gaaactgatg cgacggggtg gtcaccagca catctggctg ctgtctggtg atttcagcaa 422341 tcgacatgcc tttttcatcc agcatgatcg tctttacttg ttttccggca ttcttcaaaa 422401 gctgatacat gcgcctgtag ccaggctcct ccatcgcata cacggcttcc ttgggtaaaa 422461 gctcagtcaa cagctgcatg agcacctgtg tgcctgcccc tatgatcatt tgttccggcc 422521 tgcattttac acccctcgtc agggaaatga gcctcgtaat ggccgctctc acttcatata 422581 tcccttgcgg atgtgacata tcgccgagcg tgcggtatga gcgggaggcc gctttttgct 422641 cgcagcggaa ccagcttttg atcggaaaat ggtctgtatc ggaactcatg tgtgaaaacg 422701 atatccaatc gctctggtcg atgtgaatct cttttaggtc atccggcagt gcaaatggag 422761 ggtgctcctc ggcggaaaac atgtctagtt cctccacgaa gaaacccttt cgttcaatgg 422821 cgtacaaata cccctcagcc agcagctgct gataggctga attcactgaa tttacgctga 422881 ccttgagatt ttcagccagc tcccgcttgg agggaacctt cgagtgcggc agcagattgc 422941 ggctgaggat ttcttttttc agcttttgat aaatttgctg atagatataa tcggcttgtt 423001 ctgaacgatc gagtgtaatc gtgatatcca ttttgtagtt tctccttctg ataccatcaa 423061 aaagttataa ttggtacttt tcatcatacc aaagagaagt cagaatgata agaaaatacc 423121 gacaggggga tattcacatg agtcaaacaa cagcaagcat cacaactgca caatggcagc 423181 aaaaacggga tcaatttgtg tcaaaaggtg tgagcaacgg caaccgcagt ctggcggtca 423241 aaggagaagg ggccgagctg tacgatctgg atggccggag atttattgat tttgcaggcg 423301 ccatcggcac gttaaatgtc ggacactcgc atccgaaggt ggttgaggct gtgaagcggc 423361 aggcggagga gctgattcat cctggtttta atgtcatgat gtacccgact tatatcgaat 423421 tagcagaaaa actgtgcggc atcgcgccgg gcagccatga gaaaaaagcg atttttctta 423481 actcaggggc agaagcggtc gaaaacgctg tgaaaatcgc cagaaagtat acaaagcgcc 423541 aaggcgttgt ctcgtttaca cgcgggtttc acgggcgcac gaatatgacg atgagcatga 423601 caagcaaggt aaaaccttat aaattcggtt tcgggccttt tgcgccagag gtttatcaag 423661 cgccgttccc ttattattat cagaagccgg ccggcatgag tgatgaaagc tatgacgata 423721 tggtcattca agcattcaat gatttcttta tcgcttcagt ggcgcctgaa acggtggcgt 423781 gtgtcgtgat ggagccagtg cagggagaag gcggatttat tattccttcg aaacggttcg 423841 tacagcacgt cgcttcattc tgcaaagaac acggcattgt ttttgttgct gatgaaatcc 423901 aaaccggctt tgccagaact ggcacttatt tcgcaattga gcactttgat gtagtgcccg 423961 atctgatcac ggtttctaaa tcgcttgcgg caggcctgcc attaagcggt gtgatcgggc 424021 gtgcggaaat gcttgatgcg gcagcgccag gggagctggg cggcacgtat gccggcagcc 424081 cgctcggctg cgcggcggct ttggcagtct tggatattat cgaagaagaa ggactgaatg 424141 agcgatctga agaaattggc aaaatcattg aagacaaggc gtatgagtgg aaacaagaat 424201 tcccgttcat cggtgacatc cgcagactcg gggcgatggc cgcaatcgaa atcgtcaagg 424261 atcctgacac gcgtgagcct gataagacaa aagcagcagc gatcgcggcc tatgcgaatc 424321 aaaacggatt acttttgctg acagcgggaa ttaacggtaa tatcatccgc tttttgacac 424381 cgctcgtcat ctcagacagc ctattaaatg aagggctcag catcttggag gcgggcctgc 424441 gagcttaatc attggaaaga aaatggccgg gtctgctatc attttaagta atcatgaaaa 424501 gaaaggaatg ttcaatatgc cagatcaatt aacggtctac aacccggcta cgggcgagga 424561 gatcaaaacg attcctcagc aatcagccac agaggtagaa gaagccattg aacgttcaca 424621 tcaagcgttt aaaacgtggt ctaaaacatc agcgaacgaa agaacgtctc ttttgaaaaa 424681 atggtatgag ctgattgttg aacataaaga agagcttgca gatttaatta caaaggaaaa 424741 cggaaaacca taccaggaag cagtcggcga ggtactttac ggcgcaggct atatcgaatg 424801 gttcgcagag gaagcgaagc gtgtgtacgg aagaacggtc ccggccccga caactggtaa 424861 acgaattgtt gtcacacgcc agccggtcgg ccccgttgct gctatcacgc cctggaattt 424921 cccgaatgcg atgattacac gcaaagcggc gcctgctctt gccgccggct gtacatttat 424981 catcaagccg gcgccggaca caccgctgtc tgcttatgaa ctagcgcgcc tcgcatatga 425041 agcgggcatt ccgaaggatg ttcttcaggt tgtgatcggc gatggagaag aaatcggaaa 425101 tgtgttcaca agcagtccga aaatccgcaa aatcacgttc acaggctcaa cacctgtagg 425161 gaaaatcctt atgaaaaaca gcgctgacac cgtaaagcac gtctcaatgg agctcggcgg 425221 acacgccccg ctgatcgtag atgaagatgc ggacattgac cttgccgttg aacaggcgat 425281 ggcgtccaaa taccgaaacg ccggccaaac ctgcgtatgt gccaaccgcc tgatcgttca 425341 tgaatccatt aaagatgaat ttgctgcgaa actgagcgag caagtgtcta agctgaaagt 425401 cggaaatgga cttgaggaag gcgtcaatgt cggcccgatt atcaacaaac gaggcttcga 425461 aaaaatcgtc agccaaatag atgatgcggt tgaaaaaggc gcgaaagtga ttgctggggg 425521 cacatatgac cgaaacgatg acaaagggtg ctactttgtg aatccgacag tgctcaccga 425581 tgtcgatacg tccatgaaca tcatgcatga ggaaacattc ggcccggtcg ccccgatcgt 425641 cacgttttct gatattgatg aagcgattca gcttgccaac gatacaccgt atggcttggc 425701 tgcttacttc ttcacagaaa actaccgccg cggcatctat atttccgaga atctagagta 425761 tggcattatc ggctggaatg acggcggacc gtcagcggtt caagcgccat tcggcggaat 425821 gaaagaaagc ggcatcggcc gtgaaggcgg ttcagaaggt atcgagccgt accttgaaac 425881 aaaatatttg tccatcggtt tataaaagaa tgcacgctcc tgagagctgc cggattttcc 425941 ggcagctctt tttgtgttcc ggcgaataat cacaacaatt ccagccaaaa taacagcaaa 426001 tacattttga aagaaggttc cccaacaatg gatttattat tggctcttct cccggctttg 426061 ttttggggga gcattgttct cttcaatgtg aaattaggcg gcgggccgta cagccagaca 426121 ctgggaacga cgatcggggc actcattgtt tctatcgtta tttacttttt tgttcagccc 426181 gttctgtccc ttcgcatttt tattgttgga atcgtatccg gcttattttg gtcacttgga 426241 caggccaacc agttgaaaag cattcaattg atgggcgtgt cgaaaacaat gccgatttcc 426301 acaggaatgc agctcgtttc cacctcgctg ttcggtgtga tcgtgttccg cgaatggtca 426361 acaccgattg cgattacgct tggcgttctc gctttgatct ttatcattgt gggaatcatt 426421 ctcacgtcct tggaagataa gaatgataaa aaagagggcg agccaagcaa tttgaaaaag 426481 ggcattttga ttctccttgt ttcgactctt ggttatttgg tttatgtagt cgtggctaga 426541 ttattcaatg tgtccggctg gtccgcgctg ctgccacagg caattggcat ggtggtcggg 426601 gggttagttt taacctatag acacaaaccc tttaacaagt atgcgatcag aaatattctc 426661 ccagggttaa tctgggcagg cggaaatatg tttttgttta tttctcagcc gcgagtcggc 426721 gttgcaacga gcttttccct ttcacaaatg ggaattgtca tttctacgct cggcggtatt 426781 ttcatcctgc gtgaaaagaa aacgaaacgc cagctaatag caattgcgat cgggattatc 426841 ctgattattg ccgccgccgt attcttagga atcgccaaaa caaattcata acaaatggag 426901 gaggatgtat atgtatccgg atttaaaagg aaaagtcgtc gctattacag gagctgcttc 426961 agggctcgga aaggcgatgg ccattcgctt cggcaaggag caggcaaaag tggttatcaa 427021 ctattatagt aataaacaag atccgaacga ggtaaaagaa gaggtcatca aggcgggcgg 427081 tgaagctgtt gtcgtccaag gagatgtcac gaaagaggaa gatgtaaaaa atatcgtgca 427141 aacggcaatt aaggagttcg gcacactcga tattatgatt aataatgccg gtcttgaaaa 427201 tcctgtgcca tctcacgaaa tgccgctcaa ggattgggat aaagtcatcg gcacgaactt 427261 aacgggtgcc tttttaggaa gccgtgaagc gattaaatat ttcgtagaaa acgatatcaa 427321 gggaaatgtc attaacatgt ccagtgtgca cgaagtgatt ccttggccgt tatttgtcca 427381 ctatgcggca agtaaaggcg ggataaagct gatgacagaa acattagcgt tggaatacgc 427441 gccgaagggc attcgcgtca ataatattgg gccaggtgcg atcaacacgc caatcaatgc 427501 tgaaaaattc gctgacccta aacagaaagc tgatgtagaa agcatgattc caatgggata 427561 tatcggcgaa ccggaggaga tcgccgcagt agcagcctgg cttgcttcga aggaagccag 427621 ctacgtcaca ggcatcacgt tattcgcgga cggcggtatg acacaatatc cttcattcca 427681 ggcaggccgc ggttaaacat aaaaagcgac ccagacatga catctggatc gctttcttta 427741 ttaggcacgc tttttcttta caagtgctgc tacagataaa ataatggcag ccgcagacag 427801 caccatcgct gtaatgtcta gagctgaaga acctgagttt tcggaatcgt cttctgtttt 427861 cgtggcgccg tgctcatctg tcacttgctt tgcagacgtg atgtttgtaa tggaatgagg 427921 tgtatcggca tcctcgtcac ctgtccactc aacaatgctg ccgtctttgt aatattggta 427981 tgcgtcccaa gcagcttcct ccgctttgtc agggtttttg gcaacaaagg taaactgctg 428041 gaactggcct tcctgaatgc ctccgtcagt cgcctcccat gtcacggata ctgatttgtc 428101 atcatgtttt tgagtggaaa ccttccagcc cggaattggc tcatattgct ggaattcaac 428161 atccttcggc attttgagga caaccttcgt tgtcggcaga tttttctcag aaggaacctt 428221 cattgtatac gtttcccaag agcctgcagc agactcagcc ggttttacag aaacatgcgc 428281 gctggcaggg gccgtaaaga ataagaggga gccgacaata gccggacata gtgtcaatgc 428341 gatttttttc aacaacgtaa acactcctta attggtcttt gtaaacatga tattgatttc 428401 gttaaagtcg ccggtcaggc cgtggacttt gatcttccag tttccttttt cattaatcga 428461 caggttttga tcttggaaga cgccttttgt tttttctttt aatgtaaagg tgcttttgtt 428521 ttcgctgcct gacaggcctg ttttataaac ggttaacgtg atttgctgga tgtttttcac 428581 gggatcaccg ttatggtcgg tgacccgcag ctcaaaaaca ttttttccag gctggtttgg 428641 gctgatgctg agagaaacgc tttgtccgtt ctctatcgct ttggtttggt agaacggttc 428701 cggcgctggc tcaggcgggc ttggcaggct tgtaaacacg gccgctgtga tcaatacagc 428761 gatgccgatt gcccactccg ctttcaacgt tcggctgatt cctgtgcggc gctgctttct 428821 ggtaagcaga aaatgaattg cgcctaagac cagcatgaaa acaaacagcc cgcttttcac 428881 taaaagagct tgtccgtacg ctgtatggaa cagtgaatcc attgaacgaa tgatgaaaaa 428941 tccattgagc aagcctgaaa acaaaatgac gccgactgca gtgagcgccc atggggagaa 429001 ccgtctgacc gtctcccacg cgagcgtttt gtcaggctgc ctccattctt ttgagagcag 429061 caaaacgagt gccgctattc cgccgaccca gatggaagcg gaagttaaat gaaggaaatc 429121 catcaaaatg ccgaccgttt tttcttcaac gacagcagca tgcccggtaa acgccttggc 429181 aagcaggaga ccgaaaaaga aaatgagcgg cgctgtccaa tagccaaagg atgaaaagcg 429241 gtttttccgt atcgcaggga tgacagacag tgcgagcagc acgaacagcg cagcctgtat 429301 gatccaaatg gagccgcctg ctgtctcaaa cagtgtttct ctgatgtagc ccggctggaa 429361 tgcgctgccc cagccgccgc ctgcgttcgc ttttgtctga atcggaagct gaagcaaaag 429421 cgccagcccc aatgctgcga tcgagccggt caggatacgt ctcgtccgtt tgacgagctg 429481 ttctgatttc cctttatacc agaaaagatg gaagaaaacc gttccgataa acagagataa 429541 ggctgtatac agaatcgcgc gatctgctgc tgttcccgga ttcagcgctg aatcggctgc 429601 tttttggctg ctgaatccgc catccgcttt cccgatactg aacggaatga cgccggaaac 429661 aggatgtcca tccgcggata cggcattcca ttccgctctg tacacatctt taggcagatt 429721 cttcttcagc ttcactgtca tgatgtgatg attatctttt ttgatttcag tcttgtccgt 429781 atccacacgg tcgccgtttg aattatagac tttaatgtaa tgaaaccctt cttcaaccgg 429841 ttcattaaat tcgatttcca cctgcgcagg ggcgcttttt aattcgctgt tttccccagg 429901 tgaagatttg acaatatagg cgtgagcaaa gcttgttttc ggcaggaaaa caagaaaaag 429961 cagaaggatg atccaccatc tgtttcgctt catcactcag acaccacctt ccgctgtatg 430021 tgttgtgtta tttcttggtg caggtgcagc gtttctttcg gtcttgaagc atgtcttcca 430081 gcgcttggtc gaaagtgcag acggctccgc cgaatccttt ttgaaatcgt tcggcatggt 430141 caagtgtcgc aaacggaatg gcctgcggct ggcagcagtg caggtttaat tcagcattta 430201 cgacgaaata agccgaaccg gcactgacgg ttgtctgtaa cagaaaatct ctgcaaatca 430261 agtgtgaaac ctcttccgtt ttatccgcgt aacgcaaaaa cgcgcaatgt gcgcagcata 430321 gctgttcaat gtcttggttt accgtaatca gctgaaccga atgagcttga ttgacgggct 430381 tcaagcaata gctgcacata tgatctgttt gaggtgttcg gacggggagc gtgatgccgc 430441 cggccgtttt aatgacctga tttgactgaa ccagctgatt gacatctcta tataccgtca 430501 tttccgaaac gccgaacctt gcgctgatgt cagaaattct aagcgagcct tcttctttca 430561 gccacttcag tatgtgttgc tgtctattaa tcggaagcat tcatacaccc tcttcattaa 430621 gatctattta agcgtagagg attttagaga cggagacaag taagtggatg ataaaaaatg 430681 tgaaaatgtg ttgaacagca acaaaacgaa acagaaggga ctctggtata atagacagat 430741 ggaatagaaa gtgaggaata ccctatgaaa gaaacaccat gcccgaactg cggcaaacct 430801 ttgacaggcg atatggtcag atcatcaaat gtgccttgtc aatttcgctg cggccactgc 430861 cgggaacggc tttatgaata taaagtttca gctccgatta tgctggtatc attagcggcc 430921 atcgtgctgc ttatttatct tttgatgctc ctccgcaatg cggcaggctc agtgctgcca 430981 gctgtacagc acgtgccgat ggctgtattt gcgcttgtgt gcgcgtatcc cgtttttatt 431041 gtgagtgagc ggatgattgc aaagtacgtg attcaaaatg gcaacatcat ttatagagga 431101 aagagaaaag gctcctgaaa ccaggagcct ttttattttt aaaaaattgt cacagtcatg 431161 tgccaaagtc ctctttactt tcaattgtat agggactgta agcgttttaa catagagtca 431221 aagggaagca tcattctctg aacatatttt tgtatcttac agcgacaaac aaaacaggga 431281 gggtttatat atgcagcagc aagaacagca gcaaggcggc atgaaagtga aagtgcaacg 431341 ctttgggagt tatttgagcg gaatgatcat gccgaatatc ggcgcgttta tcgcgtgggg 431401 tatcattacc gcgctgttta ttccggcagg atggtttccg aatgaacagc tgaacacgct 431461 ggtcagcccg atgattacgt atttattgcc gcttttgata gcgtatacag gcggaaaaat 431521 gatctacgac caccgcggcg gagttgtcgg agcgacagcg gcaattgggg tgattgtagg 431581 atcggatatt ccaatgtttt taggcgcaat gattatgggt ccgcttggcg gatacctcat 431641 taaacagact gataaattat tcaaggataa agtcaagcaa ggctttgaaa tgctgatcaa 431701 caactttacg gcagggattg tcggcgcggc tttaacgatt ctcgcgtttt acgccatcgg 431761 cccggttgtc ttgacgctaa ataaattgct ggcggctggt gtggaagtca ttgtacacgc 431821 taatttactg ccggtagcca gtgtttttgt agaaccggcg aaagtgttgt tccttaacaa 431881 cgccataaac catggaatct taagcccgat cggaatcgag caagcatctc aaacaggaaa 431941 atcaattctg tttttagtag aagcaaaccc tggaccgggg ctcggcattt tgctggccta 432001 catgttcttt ggcaaaggat cttcaaaatc aacggctccc ggtgcggcga tcatccattt 432061 cttcggaggg attcacgaga tttacttccc gtacattctg atgaaaccgg ccctgattct 432121 cgcagccatt gccggcggag caagcggact cttaacattt acgatcttta atgccggact 432181 tgtcgcggca gcgtcaccgg gaagcattat cgcattgatg gcaatgacgc caagaggagg 432241 ctatttcggc gtattggcgg gtgtattggt cgctgcagct gtatcgttca tcgtttcagc 432301 agtgatcctg aaatcctcta aagctagtga agaagacctg gctgccgcaa cagaaaaaat 432361 gcagtccatg aaggggaaga aaagccaagc agcagctgct ttagaggcgg aacaagccaa 432421 agcagaagaa gcgtctgagc tgtctcctga aagcgtgaac aaaattatct ttgcgtgtga 432481 tgcgggaatg ggatcaagtg ccatgggggc atccatctta agaaacaaag tgaaaaaagc 432541 ggagcttgac atcagtgtga ccaacacggc cattaacaat ctgccaagcg atgcggatat 432601 tgtcatcacc cacaaagatt taacagaccg cgcgaaagca aagctgccga acgcgacgca 432661 catatcagtg gataacttct taaacagccc gaaatacgac gagctgattg aaaagctgaa 432721 aaagtaatct tatagaaaga gagtgattgt catgcaagta ctcgcaaagg aaaacattaa 432781 actcaatcaa acggtatcat caaaagaaga ggctatcaaa ttggcaggcc agacgctgat 432841 tgacaacggc tacgtgacag aggattacat tagcaaaatg tttgaacgtg aagaaacgtc 432901 ttctacgttt atggggaatt tcattgccat tccacacggc acagaagaag cgaaaagcga 432961 ggtgcttcac tcaggaattt caatcataca gattccagag ggcgttgagt acggagaagg 433021 caacacggca aaagtggtat tcggcattgc gggtaaaaat aatgagcatt tagacatttt 433081 gtctaacatc gccattatct gttcagaaga agaaaacatt gaacgcctga tctccgctaa 433141 aagcgaagaa gatttgatcg ccattttcaa cgaggtgaac tgacatgatc gccttacatt 433201 tcggtgcggg aaatatcggg agaggattta tcggcgcgct gcttcaccac tccggctatg 433261 atgtggtgtt tgcggatgtg aacgaaacga tggtcagcct cctcaatgaa aaaaaagaat 433321 acacagtgga actggcggaa gagggacgtt catcggagat cattggcccg gtgagcgcta 433381 ttaacagcgg cagtcagacc gaggagctgt accggctgat gaatgaggcg gcgctcatca 433441 caacagctgt cggcccgaat gtgctgaagc tgattgcccc gtctatcgca gaaggtttaa 433501 gacgaagaaa tactgcaaac acactgaata tcattgcctg cgaaaatatg attggcggaa 433561 gcagcttctt aaagaaagaa atatacagcc atttaacgga agcagagcag aaatccgtca 433621 gtgaaacggt aggttttccg aattctgccg ttgaccggat cgtcccgatt cagcatcatg 433681 aagacccgct gaaagtatcg gttgaaccat ttttcgaatg ggtcattgat gaatcaggct 433741 ttaaagggaa aacaccagtc ataaacggcg cactgtttgt tgatgattta acgccgtaca 433801 tcgaacggaa gctgtttacg gtcaataccg gacacgcggt cacagcgtat gtcggctatc 433861 agcgcggact caaaacggtc aaagaagcaa ttgatcatcc ggaaatccgc cgtgttgttc 433921 attcggcgct gcttgaaact ggtgactatc tcgtcaaatc gtatggcttt aagcaaactg 433981 aacacgaaca atatatcaaa aaaatcatcg gtcgctttga aaatcctttc atttcggacg 434041 atgtgacccg cgtagcgagg tcacctctca gaaaactggg agaaaatgat agacttgtag 434101 gcccggcaaa gaaaataaaa gaaccgaatg cactggctga aggaattgcc gcagcactgc 434161 gcttcgattt caccggtgac cctgaagcgg ttgaactgca agcgctgatc gaagaaaaag 434221 gatacagcgg cgtacttcaa gaggtgtgcg gcattcagtc ccatgaaccg ttgcacgcca 434281 tcattttaaa gaaacttaat caataaccga ccacccgtga cacaatgtca cgggcttttt 434341 ttactatctc gcaatctagt ataatagaaa gcgcttacga taacagggga aggagaatga 434401 cgatgaaaca atttgagatt gcggcaatac cgggagacgg agtaggaaaa gaggttgtag 434461 cggctgctga gaaagtgctt catacagcgg ctgaggtaca cggaggtttg tcattctcat 434521 tcacagcttt tccatggagc tgtgattatt acttggagca cggcaaaatg atgcccgaag 434581 atggaataca tacgcttact caatttgaag cagttttttt gggagctgtc ggaaatccga 434641 agctggttcc cgatcatata tcgttatggg ggctgctgct gaaaatccgg agggagcttg 434701 agctttccat taatatgaga cccgccaaac aaatggcagg cattacgtcg ccgcttctgc 434761 atccaaatga ttttgacttc gtggtgattc gcgagaacag tgaaggtgaa tacagtgaag 434821 ttggcgggcg cattcacaga ggcgatgatg aaatcgccat ccagaatgcc gtgtttacga 434881 gaaaagcgac agaacgtgtc atgcgctttg ccttcgaatt ggcgaaaaaa cggcgcagcc 434941 atgtgacaag cgccacaaag tctaacggca tttatcacgc gatgccgttt tgggatgaag 435001 tctttcagca gacagccgct gattatagcg gaatcgaaac atcatctcag catattgatg 435061 cgctggccgc tttttttgtg acgcgtccgg aaacgtttga tgtcattgtg gcgagcaact 435121 tgttcggtga tattttaacc gacatcagct caagcctgat gggaagcatc ggcattgcgc 435181 cttctgcgaa catcaatcca tccggcaaat atccgtccat gtttgaaccg gttcacggct 435241 cagctcctga cattgccgga cagggccttg ccaatccgat cggccagatt tggacagcga 435301 agctgatgct cgaccacttc ggagaggaag aattgggggc gaaaattctg gatgtaatgg 435361 agcaagtgac tgccgacggc atcaaaacac gcgacattgg gggacaaagc acaacggctg 435421 aggtcactga tgaaatctgt tcgcgcttaa gaaagctctg atgaatcagg ccggtggcag 435481 atggctgccc cggcctgtcc atttccttac gaaaatttcc acgaaagtct aaccaagcag 435541 atccaaatgc tgtataataa tttggaattc ttaggaaagc atcgggtgaa ggaagttgaa 435601 tgcaaaaaca atcacgttaa agaaaaaaag aaaaatcaaa acgatcgttg tactcagtat 435661 cattatgatc gcagctctca tttttacgat cagattggtg ttttacaagc cttttcttat 435721 tgaaggatca tcaatggccc caacgcttaa agactcagaa agaattctgg ttgataaagc 435781 agtcaaatgg actggcgggt ttcacagagg agacatcata gtcattcatg acaaaaagag 435841 cggccgctca tttgtcaaac gtttaatcgg tttgcctggt gacagcatta aaatgaaaaa 435901 tgatcagcta tacataaatg ataaaaaggt ggaagaacca tacttaaagg aatataaaca 435961 ggaggtcaaa gagtcgggtg taaccttaac aggtgacttc gaagttgagg ttccttccgg 436021 taaatatttt gtgatgggag ataaccgtct caattcactg gatagcagaa acggaatggg 436081 catgccttct gaggacgata tcatcggtac tgaatctctc gtcttttatc cattcggtga 436141 gatgagacag gcaaaataaa atgcaatgca aaaagaacat ggaacatgac ggcaccgata 436201 ataaagcgcc gtgcacgttt aaaaaaatga tgatgaaacg gtgcggagcc ggctttccgc 436261 cccgtttttt atgatagaaa gcgttttgaa gaaaagggcc ctgttgaaat aaacagaatc 436321 aggattggcg aagccgtgaa gcgcatcgaa ttggtaaatc tcaagatggg tatgctgttt 436381 ttcccgcagt tttttgataa gaagcgctac gtcaaacgac ggctcataat tagggaaaaa 436441 caataggacc gggcaggctg gcatgtgatg aagagagtcg cgtatccggg aaccgtaata 436501 acaaaccgat ccgctcacct caggcatact gctgcatttc catgcgatag tagcccccac 436561 gctgaatcca atcacaaaga tgtgccgtcc ggcgttttgc ctgatcacat tctggatgat 436621 ggtttctccc gttttcagcc tttcgtgttt tgtaaattgt tcgtatgccg ttttttcttc 436681 tttcagtgtg tagacttcat cctcgccgag caggttgggc gtcaacacat catatccagc 436741 cattttgatc agccggccca tctttttcat atggctgttt acaccatata tttcgtgtgc 436801 gagaatgaca agcggttttg ggaacataac ggcctccttt tgtgtttttt ccattatatc 436861 ctatcgtttc actttaggct gagatataat ggtcaaaaaa aggagatata aaatgaactc 436921 attatctttg cctcaccgct atccattttt gtttattgat ggcgtgacgg atagcgagcc 436981 cggcaaacat gcggcagctt ataagctgat tagtgagaac gactggttta tcactgatac 437041 gcaaacagaa atgccgtttt cacttgtgat tgaagcgctt gcgcaaaccg cggcttttac 437101 aggaattaca gatgagaaca gcttgggatt attgtcttcg gtgaagaaag cggaaaagct 437161 gggagaagct gtgcctggtg accggcttga tcttacgttt gaagtcacgc gcaatcggcg 437221 cgggtttgtg ttcggacatg ccaaggcatc agttggagag cagcctgttg ctgaagctga 437281 aatcggcatc tatattgaaa aatgaaaaaa acccttcaca acattttgtg aggggttcta 437341 ttttgtgtcg taatcccgtt cgctttgaga gttatctctt tgctggcgtt tgtgtttttc 437401 atcattcata ttttccttca gctcttcatt aggaatcgga tcggttaagt cgttgtgctc 437461 ggggttttca tttggtttgt tttgctgttt tttttctgtc atgtttgatc acctcaccgt 437521 ttgttttcct cttattcatt ctcctcaaac ataggaaatc gcttttttgt cccgctgggt 437581 ataatgtatt agaatagaga gaagcacaac aaaaagataa agagaggtac atatatgtct 437641 gttcaaagag aagatgtaga tatcaagctg atcgcaattg atatggatgg tacactgctg 437701 aacgacgagc agctgatctc ggatgaaaac cgcaaagcca ttcgtgaagc ggaggataaa 437761 ggtgtgtatg tggtgatcag cacgggccgg acgctgatga cgtgcaggga gctggcggaa 437821 tcgctaaagc tgtcatcctt tctaatcacg gcaaacggca gtgaaatttg ggattcgaat 437881 tttaatttgg tggaacggaa gctgcttcat acggaccata ttcaaatgat gtgggatttg 437941 cggaataagc acaacactaa tttctgggct tctacggtga ataaagtatg gagaggcgag 438001 tttccggaaa acattacgga tcatgaatgg ctcaaattcg gctttgacat cgaggatgac 438061 gatatccgaa acgaagtgct tgaggagctg agaaaaaaca aagagctcga aatcacaaat 438121 tcaagtccga caaacattga agtcaacgcg cttggcatca acaaagctgc agcccttgcc 438181 aaggttacgg aaaaactcgg ctttacaatg gagaatgtga tggcgatggg cgacagcctt 438241 aatgacattg cgatgatcaa agaagcgggt cttggcgtcg caatgggcaa tgcgcaagac 438301 atcgtaaaag aaacggctga ttatatcacg gatacaaata ttgaggatgg tgtcgctaaa 438361 gcgattcgcc attgggtact ataaaaaaag agagtcctaa gatggactct cttttttagt 438421 ttggcaggtt ttattctggg accatggtag gttttctgac aaaagtattt cacaaactga 438481 tatgattcac ttataatgaa ataaagttca aaaattcgga atagtcgttc cgaatttcgg 438541 gacaataaat gacataaagc atatcgtttg ctttggcagg agggattctg tgtttcagat 438601 tgatttaaac tgtgatttag gagaaagctt cggagcctac aagataggcc ttgaccaaga 438661 tattttagag tatgtgacat cagcgaatat cgcatgcgga tttcatgcag gagatcctag 438721 tgttatgcga aaaaccgtcg cgcttgcagc agaaagaggc gtgaaaatgg gtgcgcatcc 438781 gggcttgccg gatttactcg gttttgggcg ccgcaatatg gcgatttctc ctgaggaagc 438841 gtatgatctt gtcgtttatc aaattggcgc gctctctggc tttctaaaag cagagggact 438901 tcacatgcag cacgtcaagc cgcatggcgc tttatacaat atggcggcag tcgatcaaaa 438961 actgtcggat gctatcgcga aagctgtcta taaggttgat cccggcctga ttcttttcgg 439021 tcttgctgag agcgagcttg taaaagcggg agaacggatc ggacttcaga ccgcaaatga 439081 agtgttcgcc gacagaacat accaatcgga cggcacgctg acaccgcgct cccagccgga 439141 cgcactcatt gaaagtgatg atgccgccgt cacccaggtc atcaaaatgg tgaaagaagg 439201 ggcggtcaaa tctcagcaag gacatgatgt gtcattaaaa gcagatacag tctgcattca 439261 tggagatgga gcccatgcgc tgacatttgc gcaaaaaatc agaaaacagc tcaaagcggc 439321 tggaattgaa gtgacagcta tttcagaaca gaggtcaaca taaaggagga acaatagatg 439381 gagcagcaga aaaagacagc aggaaaaaaa gcgggcagct ggtcattgct gatgggcgcc 439441 gcctttttaa tggcgacatc agcaatcgga ccgggtttcc tcacccaaac cgcaacattc 439501 acaaacacac tcgcagcaag cttcggtttt gtcatcttaa tctctattat tttagatatt 439561 ttcgcccaaa ccaatgtgtg gcgcatcatc gcagtttctg gaaaacgagg tcaggaaatt 439621 gcgaatatgg tgcttcccgg actggggtat ttcatcgcca ttctcgtcgt gcttggcgga 439681 ctagctttta atattgggaa tatcggaggg gccgggctgg gacttcaggt gctgttcggc 439741 attacacctg aaacaggcgc tttaatcagt gccgttatcg ccattttgat ttttgtcatc 439801 aaggaagcag gaaaagcgat ggaccgtttt acgcaaatcg cggggttcgt gatgattatt 439861 ttaacggtct acgttgcggc gacgacagct cctccggtcg gacaggcagt cgcaaataca 439921 ttcgtcccgg aacacatcag catatttgcc attgtcaccc tagtgggcgg aaccgtcggc 439981 ggttatatca catttgccgg aggacaccgt ttgcttgatg ccggaattaa aggaaaggaa 440041 tccattccgc aggtgacaaa gagctcggtt gtcggcattt taattacatc tgtcatgcgt 440101 atcgctcttt ttcttgcggt tctaggcgtt gtatcgaaag gcctgcacat cgatgaaagc 440161 aacccggcgg cttctgtctt caagctggct gctggaaatg tcggttataa aattttcgga 440221 ttgatcatgt ggtctgcggc gattacgtct gttattggag cagcctatac atctgtttca 440281 ttttttaaaa ccttttctcc aaaaattgaa aagaattcac gcggtattat tatcggattt 440341 attgtggttt ctacgttagc ttttgtcaca atcggccagc ctgcgaagat cctcgtcctt 440401 gtcggttcac tgaacggctt aattctgccg attgcgctcg gaacgctgct tgttgccgcc 440461 tacaagaaaa acattgtcgg tgattataag catccgcttt ggctgacaag cacaggcgcg 440521 cttgtagtga ttgtaatggc agttatggga atctacacgt tatgtacaca acttcctcaa 440581 ttgtggagct gatataagtg gagcaattaa acaaaatggc gccaaaggat gtacgcgccc 440641 tgatacgaga ggggaaaata aacgggccga ccgcaggcat gtccggcggc tacgcccaag 440701 cgaatcttgt ggttttgaaa aaggaccttg cgtttgattt tctgctgttt tgccagcgaa 440761 atcaaaagcc ctgccccgtg ctggatgtga ctgaagcagg ttcgcctgtg ccgtctctgg 440821 ctgcgccgga tgctgatatc agaacggact ttccgaaata ccgtatttac aggcacggta 440881 tcctaacgga agaagtatct gatattacgc catactggga ggacgatttt gtcggctttc 440941 tgatcggatg cagtttctcc tttgaacagg cactgatcaa taatgggata gctgtccggc 441001 atattgatga ggggacaaac gtctcaatgt ataaaacgaa tatcgattgt gttccggcgg 441061 gggcgtttca cggacagatg gttgtcagca tgaggccggt tcctgaacgg ctggctgtac 441121 gtgctgcaca agtgacctcg cgttttccgg ctgtgcacgg agggccgatc catattggca 441181 atccgggagc aatcgggatt cgcgatctcg ggaaaccgga tttcggagat gccgtttcca 441241 ttcgtgacgg cgaggttcct gttttttggg catgcggagt gaccccgcaa gccgtggcta 441301 tgaatgtaaa gcctgaaatg gtcatcacac atgcgccggg gcatatgctc atcacagata 441361 ttcgagacga gtcgcttgcg gtgctgtagc ctctcgtcat cctgatgaac gagaattaaa 441421 agaggtgaga aagatgactg tacgatatca aatcgaacag ctcggtgatt ctgcaatgat 441481 gatccgattc ggagaagaaa tcaatgaaca ggtcaacggc attgtccatg cagcggccgc 441541 ttatatagaa gaacagccat ttccgggatt cattgaatgt atcccggctt ttacaagtct 441601 aaccgtattt tatgatatgt atgaagtgta caagcatttg cctcaaggca taagctcacc 441661 ttttgagagt gtcaagcgcg atgtcgaaga gcggctggca gaaatagccg aagactatga 441721 ggtcaaccgc cgtattgtag aaattcccgt ttgctatggc ggtgaattcg gtccggattt 441781 agaagaggtg gcgaagatca atcaactgtc accggaggaa gtaatcgaca ttcatacaaa 441841 cggtgaatat gtggtgtata tgcttggctt cgcgcccggt tttccttttc taggcgggat 441901 gtcaaaacgc attgcagctc cgagaaaatc atcgccaaga ccgtcgattc ccgcaggttc 441961 ggtcggtatt gcgggattgc agacaggcgt ttatccgatt tcaacgccgg gcggctggca 442021 gctgatcggc aaaacgccgc tggctctttt ccggccgcag gaaaacccgc cgacattgct 442081 gcgggcggga gatattgtga aattcgttcg catctcagaa aaagactatc acgcctataa 442141 ggaggagtcc aattgagcat gaaagtatta aagcccggac tgctcacaac ggttcaggat 442201 ataggcagaa cgggttacca aaaatacggc gttctggcca gcggcgctat ggacacggtt 442261 tcactgcgca ttgccaatct gttgatagga aacggcgaaa atgaagcagg tctcgaaata 442321 acgatgatgg ggcccggtcc gtcgtttcat ttttcaaaac agacactgat tgctgtgaca 442381 ggggcggact tcacgctgcg tattaatgac gaggaagcgc ctttatggaa gcctgtgctc 442441 atcaaggaaa acagcacggt cagctttggc ccctgcaaac tcggcagccg tgcttatttg 442501 gcggcagctg gcggcattga ggtgcctgcc gtcatggaaa gtaaaagcac atacgtcaga 442561 ggaagcattg gcggacttca tggcagagcg cttcaaaaag aagatgaact gaacattgga 442621 gagatgtcag ctctttcgca aaccatcctt tctcgcttaa gttcgcagct tggaaaacag 442681 ggatttgcag caccgaagtg gtcagtcagc cgcggcagat ttctgccatt gaagaagaat 442741 cccgtcattc gggtgctgga aggaaagcaa tttgcctttt tcacagaaga atcaaaaacg 442801 cgtttttatg aagaagcatt tcgtgtcacg ccgcagtccg accgtatggg ctacaggctc 442861 aaaggagaac cgctcgaact gaaggccccg cttgagatgg tgtcggaagc ggtttcattc 442921 ggaacagttc aggtgccgcc tgacggcaac ccgattatcc tgcttgcaga ccggcagacg 442981 actggcggct atccgaggat cgcgcacatc atatccgctg atcttccgat tgtttcccaa 443041 atcatgccgg gcgagcacgt tcagtttgag cctgtgtccc tccaggaggc agaagcgctt 443101 gcggtagaac gggaacagca tataaaagaa ctgaaaacga gaatgaagat ggaatggctg 443161 acatagcaaa ggggatgaat gatgcagaat aaaaataaaa ccgtagtcaa atctatggcg 443221 ctgcttaatt tgtttttgca taaaccaagc ctaaccttaa gtgaactggt gtcgctgacg 443281 ggaatgccga agacctctgt tcaccggatg gtcagctcct tggaggaaat ggggttcctc 443341 agtcgggatg cgtccggcgc ttattcgctg ggattggtgt ttttggaatt cggacagctt 443401 gtcgctgaca ggctggatat cagaaaaata gcgaaaccgg tgatggaaga gctgtgccgg 443461 gaagtggatg aggccgtgca gttgatcatg agggacggca atgaagcgat atacgttgag 443521 aaaatagaag ggacacagac tgtgcggctg tatacggcga tcggcaggcg ttccccccta 443581 tacgcgggag cgtgcgccag aagcattctg tcctttcttc cccgtgaaga aatcgaagca 443641 tacatcaaac aaaccgagct catttcgatt ggctccggaa cgattaccga tcccgaaaaa 443701 ctgcttcagg agattgatgc ctctgtgcaa aatggctata ctgtcagcta ttcagagctc 443761 gaaaactata cggcggcgat cggcgccccg atctttaacc atgagcgcca ggtggcagcc 443821 ggcattagca ttgcaggctt tgaagcgaga tttacagaag acaggctgcc ctatttaaca 443881 gaaaaggtga aggacgccgc tttacagatt tcaagaaaaa taggatatac ataagtagcc 443941 aatcttttct ctgctgcgta cattaacgta tcgacgttca agagtggagg aaagaacatg 444001 gtgcttcgat atacagctct gggcgattcc ttgacgacag ggagaggctc cgggctgttt 444061 tcacccggct tcgtccagcg ttttggggac atgatggaag ctgacttgaa aacaagaacg 444121 gcaataaaca tatttgccag atcaggtctg aatacagaag agattttggg actcctgtca 444181 tatccctatg tgcaaaaatg tattcgagat gctgatatga taacgatcac agggtgcgga 444241 aacgatctca tcgattcggt cttagcctac caaacctcta aggatgaaac gattttcagc 444301 cgtgtatccg cccattgcca tgagaatttt gaaaagatga ttgccaaagt cgccgagatt 444361 aaaggagaaa atccttcccc gtacgccatt cgtgtgttca acttatacaa tccgtttccc 444421 gaaattgata tcgccggcaa atggatcact tcgtttaatt cacatttaga aacacttgca 444481 tcagcacccc atgtcaaaat cgcggatgcc tatagcatct tcaaaggcaa agaacaggaa 444541 tatctgtcct ttgacggtgt ccatccgaac agcaaaggct atcaagcgat ggctgaagcc 444601 gttcacaagc taggctataa agaattatca gtttcataga aaacgcgcct catgacaggc 444661 gcgtttttta tgtgtgatcg aaatattaaa agaaacttaa aattctctgt cttctgttct 444721 acagacaaac aaagtgcgct agaataatgg agggcgtagg caaatatagc cataacgttc 444781 aatatttcgt atataaggaa ggatggtcct tttgtttcgg atttttaaaa tgtcttttgc 444841 ggttatcatt attatactgg cgcttattgc ttttaactat acggaacaca cctctgtaat 444901 ccaatcggtc atgctcgtct ttcttggtgc ggtcatgttt atgcaggggc ttgaagagcg 444961 caaaaaagaa aatgacggct caggcgcttt taatatttat accgccgttt ttgtatggtc 445021 tgtctccctt atcggtttta cacttcatat tatataaatc tattacacat cctgaaaatg 445081 ctcgaccgtc gggaacgggg tatagaaccg atgaagcaag gctttccact cttgatactc 445141 tgaagaaccg cgaaagcctt ccgtatggtc ctcaagtgtt tcccactcca caagaagcag 445201 atatttatgc gtttcctcca tgcattttga taacgagtga gtgatatagc ccttcatgcc 445261 ggaaataatc ggcgcagctt gccggaatgc atcctcaaac tcttgttcaa ggccttcttt 445321 aatgtgaagc attgctgcct ctctgaccat gctatccctt ctttctgtct tttcaaatag 445381 tctacagcaa acgataggag atttctgcaa aatcggtgaa cttttccttc attttcaaaa 445441 aaatcttgca cgcaccaatt caattaagag aaaataacaa gtggaaggca ggggaaagtc 445501 atgttaaaaa agtgtattct actagtattt ctatgcgtcg gattgattgg gttaatcgga 445561 tgctccaaaa cagattcacc agaggatcgc atggaagcat tcgtgaaaca gtggaacgat 445621 cagcaattcg atgacatgta tcaaagcctg actaaagatg tcaaaaaaga aatctccaaa 445681 aaagatttcg tcaacaggta taaagccatc tatgagcagg ccggcgtaaa aaatttgaaa 445741 gtcactgcgg gagaagtaga taaggacgat caagacaaca agacgatgaa acatatcccg 445801 tataaagtca gcatgaacac aaatgccggc aaagtcagct tcaagaatac tgctgtgctg 445861 aaattagaaa aaacagatga cgaggagtca tggaatatag attgggaccc atcgtttatt 445921 ttcaagcagc tggctgacga caaaaccgtg caaattatga gcattgaacc gaaacgaggc 445981 caaatttacg ataaaaatgg aaaaggctta gccgtcaata cagatgttcc ggaaattgga 446041 attgttcccg gagagcttgg cgataaaaaa gagaaagtca taaaagaact cgccaaaaaa 446101 cttgatttga ctgaagacga catcaagaaa aagctggatc aaggctgggt aaaagacgat 446161 tcgtttgtgc cgctcaaaaa ggtcaagcct gaccaggaga aattagtttc tgaagcgacg 446221 tcattacaag gcgtaacaag aacgaatgtc agctcccgct actatccgta tggcgaaaag 446281 acagcccatt tgacaggcta tgtccgcgcc attacagcgg aagaactgaa gaaaaagaaa 446341 gaaggaacgt acagcgatac gtctaacatc ggtatcgccg gacttgaaaa tgtgtatgaa 446401 gacaagctaa gaggcacaac tggctggaaa atctacgtgc cgcaaaccgg ggaagtcatc 446461 gctgaaaaga aagcaaagga cggcgaggat cttcacctca caattgatat caaaacgcaa 446521 atgaagctgt atgatgaact gaaggatgac agcggggcgg cagtcgcgct gcagccgaag 446581 acaggcgaaa cactcgccct tgtcagcgcg ccttcctacg atccaaacgg atttattttc 446641 ggctggagcg ataaggaatg gaaaaagcta aacaaagata aaaacaatcc gttttcagcg 446701 aaattcaata agacatacgc gccaggttct accattaaac cgattgcggc tgctattgga 446761 atcaaaaacg gcacccttaa agccgatgag aagaaaacaa tcaaaggcaa ggagtggcaa 446821 aaagattcaa gctggggcgg ctattcagtg acacgtgtgt ctgagagact tcaacaagtc 446881 gatttggaaa acgcccttat tacgtcagac aatatttatt ttgcccagaa tgcgcttgat 446941 atgggagcgg acacctttac aaaaggcttg aagacattcg gtttttcaga ggacgttccg 447001 tacgaattcc cgatccagaa atcgtctatt gcaaatgaca agcttgattc agacattttg 447061 cttgcggata caggctacgg acaagggcaa atgcaaatgt ctccgcttca cttggcaact 447121 gcttacacgc catttgttga caatggagac cttgtcaaac cgacgctgat caaaaaagat 447181 tcacaaacag ctgatgtttg gcacaagcaa gtggtcacga aggaaggagc ggcagacatt 447241 acaaaaggtc tgaaaggcgt tgtggaagat gagcgcggat cagcgtatca gcctgtcgtg 447301 aaaggaatca cagtggctgg aaaaacagga acagccgagc tgaaaacatc aaaagatgat 447361 aaagacggca cggaaaatgg ctggtttgtc ggctacgatt acgaaaacaa agacctgctt 447421 gtcgccatga tgatccaaaa tgtgcaggac cgcggcggca gccactatgt cgttgagaaa 447481 gcgaaaaagc aatttcaatc gaattaaaat gtctttttaa aaggagcgaa aggaaaaagg 447541 ggatctgagg ccgaatgaac tagtaagggg gcaaaacccg gtttatacaa agaaaagagg 447601 gattttgcat gcagcgtatt caattggcgg aggatcttca attttcaaga gtcatacacg 447661 ggctttggcg gctgaatgaa tggaactatt cagatgctga acttctaagc ctcattgaat 447721 ggtgtatcga tcacggcatc acgacctttg atcatgcgga tatttatgga ggctatacgt 447781 gcgaaaagct gtttggaaac gcccttgccc tttcgcctgg attaagagaa aacatagagt 447841 tggtcacaaa atgcggtatc gttcttgaat cgcctgaacg gcccgctcac agatcgcatc 447901 attataacac aagcaaatcg catattttgg catccgttga gcaatcgctt atgaacctta 447961 ggacggatta tatcgatatg cttttgattc acagaccgga cccgctcatg gatccggagg 448021 gggtagcaga ggcgtttcag gccttgaaat gctctggcaa ggtcaggtac tttggcgttt 448081 caaattttaa agatcaccag tatcggatgc tggaatcata tttgcctgag aagctcgtaa 448141 ccaaccagat tgagctttcc gcatacgaat tagaaaatat gctcgacggc actttgaacc 448201 tgtgccagga aaaacggatt ccgccgatgg cttggtcgcc tctggcaggc ggcaaagtat 448261 tcactgaaaa cacggataaa gaccgacgtg tccgtacggc gcttgaatcc gtccaagggg 448321 aaatcggcgc cgcttcattg gacgaggtga tgtacgcatg gctgtatacg catccggccg 448381 gcatcatgcc gattgtcgga agcggaaagc gcgagcggat ttccgccgcg ataaatgcgt 448441 tgtcatacaa gcttgaccag gatcaatggt tccgcatttt tacagccgta cagggttacg 448501 atattccata aaaagcatca gtttaccagc tgatgctttt tcaatattgt cacaccgctt 448561 agtgccaaat taccatttat aagtgattga ttctttcttg aaagcgtttt atattaaaag 448621 gaaacctctc tatatcctct actgcatctc cttgcgactt catccgcaca tcaagattgg 448681 ctaggaggtc ttttttatgt atatgactgc cagagaacaa aagctgttaa agcacttatt 448741 attacaaaac agatatataa ccgtaactga gcttgctgag ctgatgcaag tcagcacgag 448801 aaccattcac agggaactca aatcaattaa accgctgatg gaaaccgtgg ggcttacgtt 448861 agataaacag cccggtaaag ggttgaaagc agtgggaagt cccgagggta aacaaaagct 448921 gcttactgat ttatcatatg aacagcatga atacagcgcc gacgaacgga aactgctcat 448981 tctttgttcg ttattagagt ctcaggagcc cgtcaaactg tacacgcttg ctcatgatct 449041 ccaggtgacg aatgccacgg tcagctatga cttagatgag ctcgagaagt ggatttctcc 449101 ctttggactg acactgatcc gcaaaagagg ttttggcatc cagctcatag ggccggagaa 449161 tgcgaaacgg aaaattgtcg gcaacttgat tgtgaaccgt ctcgacatcc aaatgttttt 449221 ggaagcggtt gaattaaaca tcaaaggaaa aaccgattct tcagagaaaa tgttcggggt 449281 tgtcagcaaa ggtgagctgt taaaaatgga gcgcatctta tttcagctca aagaaaaaat 449341 cgctttttca ttgtccgaca gctcctatat agcgctcgtc gtccatctga cgtatgcgat 449401 cgaacgaatt aagcttgggg aaactatcac catggagcaa aatgagcttg aggaactgat 449461 gaatgcgaag gaatacagct ccgctcttga aatcgcgggc gagcttgaac gtgccttcgg 449521 cgtgacgatt ccagaggcgg aggtcggcta tattacaatc catcttcgaa gcgccaatcg 449581 aaaatacaaa acagaataca aagcgcagga aattgagctg gaaacagccc tgcaaacaaa 449641 gcggctcatt gcttttattt cagacaaaat cagaatggat ctgacgaaaa actactcttt 449701 atatgaaggc ttgattgccc atttggagcc ggccgtcagc cgcataaaag aaaatattga 449761 gatatacaat ccgatgaagg aacagatcaa gcgcgattat tttctgcttt atatggcgat 449821 cgaagaaggt gtcgaaaagt attttccggg catgtccttt tctgatgatg aaatcgcttt 449881 tatcgttctt cactttggct cggctcttga aatcaaaaaa gaagaagcaa aagtgaaagc 449941 gcttgtcgtc tgctcaagcg ggatcggctc ctcgaaaatg cttgcctcca gactgaaaaa 450001 agagctgccg gaaattgaat cgtttgatat gtcatctctg atcgagctaa aggggaagga 450061 tgttcaagcc tatgatatga ttgtgtccac tgtaccgatt ccttatgaaa acattgatta 450121 catcatggtc agcccactat taaatgagga agacgcaaac caggtcaagc agtatatcaa 450181 gcggaagatt ccccttattc ttaacaaaaa aagaagctcg aaggaagagg cgcagcaagc 450241 tgatgtacct gacatgctgg aggcggcgga aagcataggg cggtatatgg aagttatcca 450301 agatgttctg cgccatttta cgctagctca actcaaaaca aacccggacc atagcatgct 450361 tctgctagag ctttttcaac agctgaagaa ggatggcctg atccgtgatc cggaaaaagc 450421 cgcggtttgc ctggctgagc gggagaaaca agggggattg ggaatccccg gaacaaacat 450481 ggcgctttat catctcaaaa atgatgaaat cgtcctgcct tttttcaaaa tgtttgatct 450541 cagcaccccc tatgaagtgg atggcatgga cggaaatacc ctcaggatga cacgcattct 450601 cgtcatgatg gcgcctggct cattatctgc tgaaggctcg gagattttaa gcgcgatcag 450661 ctcggcaatt atcgagagcg gagaaagcat ggcggggttt caggaagaag gaggacaaga 450721 attgtatcag cggttaaacc gcatattttt cacatggatg aaagaaaaaa acatactgta 450781 aacctgcatg gcacacgtca aaaatttggc gtgtgttttt ctgtggatgg ggaacaaaat 450841 aagaaaatgt gggactattt tatcattcag tattggaata attccaaaat gaaatagttt 450901 tacaagttat cttttttggg ttaaaatggg tgaggtaagg aagaaaatct aacaaattat 450961 tgaagattca agagaatata ggagatgacg atatggaaac attacagcat ctgattctgc 451021 atgacatgcc gaatagcgaa gaaatagagg ctgtaaaaag cggagaccat acactgacat 451081 ataaaggtta ccgtaaacgg attaatcagc tggcgaatgc catgcttcaa aaaggaattc 451141 aaaagggcga ccgtgttgca ttgctttgca aaaacggcca tcccgcctca actgttatgt 451201 tcgccgcact tgaaataggt gctgttgtcg tacctgtcag ctggcagctg aaaccatatg 451261 aaatgacagg cattttaaaa gcaagtgaac caaaagcgat gttttacgga gcggagttta 451321 aagagatact ggatgaagtt cttcctgaat tgtcctcact gtgtgtaaca atggaaacag 451381 gaacagctta cgaaacatct gctgaatttg aagcgctgtt tgcaggtcct gatcatttgc 451441 cagagacgga aatggtttca cctgatgata cagcacttct gatgtttaca tctggaacaa 451501 cgggaaaccc gaaaagatgc atgattacac atggcggcat atacagatac gttaaaaaat 451561 ccaacagctc aatagcacgt atgaagggcc ttcgttttct cgcgtgccat ccgatttatc 451621 atacgagtgc gctcatttgc atcatgcttg gaacgtttgc agaaacaaca tttgtgttta 451681 caaaggatca agatcctgtt cacatgctga aggtcattga agaagagaag attcagaccg 451741 tgatggctct tcctgtgttc tacacgtatt tgcttgaggc gtgggaaaag caccaaactg 451801 acttatcttc gcttgttatt ttaatgacag gcggaacaaa agtgccgagc agcctaataa 451861 gccgctatct tgatattggc attccgcttg cgcatggcta tggaagtact gaggcttggg 451921 gcatcagcac atggacgcct gatatgggaa tggataaagc ggcatctgca ggaaaacctg 451981 tggcaggtgt taaagtcaaa gtggaagatc ctctgaccgg agaagaactt cctcaaggag 452041 aaatcggcga aatcgttgtt catactccat tcttatttaa aggctatgaa gacaatcctg 452101 aagcaacagc gaaagtgctg caaaatggat ggtttagaac cggagattca ggatatgtag 452161 atgaagatgg ctttattttc atcacgggac gctacaagga tgtcattatt tacggaggcg 452221 ataacgtcta tcctgatcag gttgaagaag ttatccagca gatcccggga atccttgaaa 452281 cggctgtggt cggtattcct gacccgcttt acggtgaaaa accgaaagct tttatcgtga 452341 aaaatggcgg ccagcgcatc acggaagagg atgtcatcgc attttgtaaa gaacgcctgt 452401 ccgcttacaa aatacctgaa gttgaatttg ttaacgaact gccgaaaaac aaccttggca 452461 aggtgaaaaa agacgtcctg cgcaatcagg ctgtacattc ataaaagaag aagcccgtcc 452521 actttatgtg gcgggcttct ttgcagttgc acagacggaa agctcaggct taatgttctt 452581 aaattgtata tcaatgtctt cgaagccggc tgctttaaag tcagcaatca tctgtcttcc 452641 aaatgatttg gttttctcag gactggcatc cgcttcccgc ggctgcatcg taatggctgc 452701 tttgccgcct ggctttaatg cccgataaat ctgttttatg ccttttgttt ggtcattcca 452761 aatggtgtag ttgttaacgg aaatcacttt atcataaaac gaggcgggga gaggaaatgt 452821 ctcgatgctt ccttgtatca ggcgtacgcc ctttggtttc actctgcggg cggccagctt 452881 cagcatggcc tctgatacat caatcccatg aagatgaaca tccttctcgc gtttcagcat 452941 ctgctgcatg cagtatcccg ggccaaaccc gacttctaaa atgctgtccc cgcgcgtgat 453001 acccagctga ttgattgtcc actgattcag tgtttgattt tcagcagcca tgatgtaccc 453061 ggcaatcatg ccgatgacgc cctttggcct gctgaatctt ctagaaagca tgttaatcat 453121 tcagcaacca accccctttt tgagttaatt tcctctcagc gttccatgtg aaacattttt 453181 ctgataaagc aatgcgaagg tgccaagcca tgtttatcca aagagtgtgt gaggtacaca 453241 acaaatagac atgaaaacaa aggaggagaa tcatcatggc aaattatcca aaagaactgc 453301 cggcacaaac tcaaagtcgc cagccgggaa ttgaaagcga aatgaatcca agtccggtgt 453361 atgagtacga ggattataaa ggagcagaca aattaaaagg aaaagtagct cttattacag 453421 gcggcgacag cgggatcgga cgcgcggttt ccgtcgctta cgcaaaggaa ggcgcagaca 453481 tcgccattgt gtataaggat gagcatgaag acgctgagga gacgaagaaa cgtgttgaac 453541 aagaaggcgt aaaatgcctg ctgattgctg gtgacgtagg tgaagaggaa ttctgcaatg 453601 aagcggttga aaaaacggtc aaggaactag gcggccttga catccttgtc aacaatgcag 453661 gtgaacagca cccgaaggaa agcatcaaag atattacgag cgaacagctt caccgcacat 453721 tcaaaacaaa tttttattct caattttatt tgactaaaaa agcaattgat tacctgaaac 453781 cgggcagcgc catcatcaat acgacatcca tcaacccgta cgtagggaac ccgacactga 453841 ttgattatac agcgacaaaa ggggcgatca atgcctttac aagaacaatg gcgcaggcgc 453901 ttgtcaaaga cggcatccgt gtaaatgcag tcgcgccggg tccaatttgg acgccactaa 453961 tcccagctac gttccctgaa gaaacagttg ctcaatttgg gcaagatacg ccgatgggcc 454021 gtcctggaca gcctgttgag cacgtcggct gttatgtgct tctggcatca gatgagtcct 454081 cttacatgac aggtcagacc ctgcatgtca acggcggaaa ctttgtgacg acataagagg 454141 gagtgagaca tatgggcatc acgaaagaag aagtgaacag ctactatcaa aaagcaggga 454201 ttgtattaac ggacgaggaa gtagaccaaa tccagctgat ggattacggc ttaggaaaag 454261 aaagaaaagt cgggctccag ctcttcgtct acgtcaatac agaccgttat tgttcaaagg 454321 aattggtgct gtttccggga cagacttgcc cggaacaccg ccatccaccg gtcgacggcc 454381 aggaaggcaa gcaggagacc ttccgctgcc gctacggaaa agtgtatctt tacgtagaag 454441 gagaaaaaac gccgcttcca aaagttctcc ctcctcagga agacagagaa cactatacgg 454501 tctggcacga aattgagcta gaaccgggcg ggcaatacac gattccacca aacacaaagc 454561 attggttcca ggccggggaa gaaggtgccg tcgtgacgga aatgtcatcg acgagcacgg 454621 ataaacatga tatctttacc gatccaagaa tataaggatg ggcttaacag cccatccttt 454681 ttgtattgaa aaaaacagaa tcatcgctat aatgggtaaa aaaggaaaga gggcgaggca 454741 atgttcactt gcaaggtaaa tgagcacatc accatccgat tattggagcc gaaggatgcg 454801 gagcggctgg ccgaactcat tatccaaaat cagcagcggc ttggcaagtg gctgtttttt 454861 gcggaaaatc caagcagcgc tgacacgtac cgagaaacaa tcattccaga ttggcggcgc 454921 cagtatgccg acctgaacgg cattgaggcg ggtctccttt atgacggcag cctatgcggc 454981 atgatcagcc tgcataacct tgatcaagtg aatcgtaagg cggaaatcgg atattggatt 455041 gccaaagaat ttgaagggaa aggcattatt acagctgcct gccgaaaact cattacgtat 455101 gcttttgaag agcttgagct gaatcgtgtg gcgatctgtg cggctgtcgg aaacgaaaaa 455161 agcagagcgg ttccggagcg gatcgggttt ctagaggaag gaaaggcacg ggatggctta 455221 tacgtaaacg gcatgcatca cgacctcgtc tactacagtc tgttaaagcg tgaatgggaa 455281 ggcgaaaaat aaagagcaca ctttcttgtt taaatcttcc ccggatgtgg aaaagtaaca 455341 gcggagacgt taaaaaggag tgattcgaga tgaatcagca agacattaaa caaaaagtgc 455401 ttgatgttct agatcaccat aaagtaggtt cgctcgcaac agttcaaaag ggcaaaccgc 455461 attcccgcta catgactttt ttccatgacg ggctgacgat ttacacaccg acaagcaagg 455521 aaactcataa agcggaagaa attgagaaca accccaatgt ccacatttta ttaggctatg 455581 attgtgaagg ttttggcgac gcatatgtcg aagttgccgg aaaagcaaag atcaacaatt 455641 cggcagaact caaggacaaa atatggagtt ccaaattaga gcgctggttt gacggcaagg 455701 atgatccgaa tctggtgatt cttgaaattg aaccggagga tatcagatta atgaatgccg 455761 gggagaaaac accggtctca ctcgaactat aaaaaatttg tgttttcagg ggcgatatgt 455821 tattatgaat agctagtaag aaaaataagc aaataaaaaa gaaagtaaac ttcttttttc 455881 tgttttgaga gagaagctta ccgcttccca agcagcataa ccagctgccc ttattctttt 455941 ccttcataac aaatcgcccc taacgatgag atggaaaaaa gacttttttg ttttacaatt 456001 cacaccggcg cggcttcgga gccgcagtga cgattgagag gtagggcttt cgttgtcttg 456061 tgttcaagaa atttccatgg tgtttacttt ccagaatgat tcttcggaac aatgctttat 456121 gaatctaacc cgcctgactt ggcggatgat ataatcttta tttgcgtata gaaaagaata 456181 agacaaaccg cccggcgtac gccggacggt ttttttattg caaaaaacac atcgtactga 456241 aacctccttg tcttctttcc agtcttatct ctaggatgaa attggaggaa gaataacgtg 456301 catgtcatta caacacaagt actttttatt ttttgttttt tattgctgat tcactcgata 456361 gaaaccttag cctatgcgac aaggctttcc ggagctcgcg ttggatttat tgcgtccgcg 456421 ctttctctgt ttaatgtcat ggtcatcgta tccagaatgt cgaatatggt gcagcagccc 456481 tttactgggc atttaattga tgatgctgga aaaaacgcac tggcgattgt aggggagcag 456541 ttccgctttt taattttcgg atcgacagtc ggcaccattt tgggcattat cctgctcccg 456601 tcttttgtcg ctcttttttc acgggcgatt attcacttgg cgggcggcgg cggctccgtt 456661 tttcaagtat tccgaaaggg attctcgaaa caaggattca aaaatgccct ttcctatttg 456721 cgtctgccgt ccatttcata tgtaaaagga tttcatatgc gcttgattcc gaagcgtttg 456781 tttgtcatca acatgctgat cacatcgatt tatacgattg gtgtgctttc ggctttatac 456841 gcaggccttt tggcgccgga gcgcagcacg acagccgtca tggcttcggg tttgatcaac 456901 ggaattgcaa cgatgctgct ggctattttt gttgatccta aggtatccgt tcttgctgat 456961 gatgtggcaa aaggaaaacg aagctatatc tatttaaaat ggacctctgt cacaatggtc 457021 acatcaaggg tggcgggcac actcctcgcc cagctcatgt ttattcccgg ggcctactat 457081 atcgcgtggc tgacaaagtg gttttaataa gaaaggctgg atcataaaga tccagccttt 457141 ttgcgcttcc ttatttatag ttccttaatc cgcggtcgta caaaaaattt ccgaatggga 457201 cgaaagcggc gatgaagccg gcagctgacc atttcagcgg ccatttgaca gagaaggttg 457261 cataagccaa gacaagcaaa tacaaaatga acaacccgcc gtgaaccgaa ccgacaattg 457321 tcaccgcaag cggaaggcct gcccaatatt taagcggcat agcgatgaac aacaggatta 457381 agagtgacat tccttcaata aaacccatcg tgcgaagtct tccgatcggc gtgtgcagca 457441 taaatcgccc tccttgtgga cacgttttca ttttatacta taaacaatcc gggggggcat 457501 atgacagctt tcaaaaaatg ttcggaaaac attcattttt acatgccttt tctagggaac 457561 tgtacttgtc atttacaaaa atacccgaga taatgtgtac aaaatcaaaa aagaaggatg 457621 ttgaaatgaa acttgaccag attgatctga atatcattga ggagctgaag aaggacagcc 457681 gtttgtcgat gagggaatta ggcagaaaaa ttaagctgtc gcctccatct gtaacagaac 457741 gggtaagaca gcttgaatcg tttggcatca tcaagcaata cacgctggag gtcgaccaga 457801 aaaaactggg gcttcccgtt tcctgcattg tggaagcaac cgttaaaaac gcggattatg 457861 agcggttcaa aagctatatt caaacattgc cgaatattga attttgctac cggattgcgg 457921 gtgcagcctg ctatatgctg aaaatcaatg ccgaaagcct cgaagcggta gaagatttca 457981 ttaacaaaac atcgccctac gcgcaaaccg tcactcacgt cattttctca gaaattgaca 458041 cgaaaaacgg gcgcggttag agagtgccgc gcgaagtctg ttataataac aggatgagcg 458101 tgaaagaaag agaagtgatc aagcatgtca aaaacagttg tattagctga aaaaccttca 458161 gtcggccggg atttagcccg ggtactgaag tgccataaaa aaggaaacgg ttatctcgaa 458221 ggcgatcaat atattgtgac ttgggcttta ggccatttgg tgacgcttgc tgatccggaa 458281 ggctacggaa aagaatttca atcatggcgc ctagaggatc tgccgattat cccagaaccc 458341 ttgaagcttg tggtgataaa aaaaaccgga aagcagttca atgcagtcaa atcccagctt 458401 acccgtaaag acgtcaatca gattgtcatc gcgactgacg caggccggga aggtgagctt 458461 gttgcgcgct ggatcattga gaaagcgaat gtccgaaaac caatcaagcg gctgtggatt 458521 tcatctgtga cggataaagc gatcaaggaa ggttttcaaa agctgcgcag cggcaaagaa 458581 tatgaaaacc tgtaccattc tgccgtcgcc agagcggaag cggattggat tgtggggatc 458641 aacgccaccc gtgcacttac cacaaaattc aatgcccagc tctcatgcgg gcgtgtgcag 458701 actccgacgc ttgccatgat tgcaaagcgc gaggcagaca ttcaggcgtt tacgcccgtt 458761 ccgtattacg gcatacgtgc tgcagtcgac ggcatgacgc tgacgtggca ggataagaaa 458821 tcaaagcaga cgagaacgtt caatcaagat gtaacaagcc gtttgctaaa aaatctccaa 458881 ggaaagcaag cggtcgtagc tgagctgaaa aaaacagcga aaaaaagctt tgcgcctgcg 458941 ctttatgatt taacggagct ccagcgtgac gcccacaagc gcttcggttt ttctgccaaa 459001 gaaacgcttt ctgtcctgca gaagctatat gagcagcata agctcgtcac atatccgcgg 459061 acggactcta gatttttatc cagtgacatc gtcccgacgt taaaagaccg tctggaaggc 459121 atggaagtaa aaccgtatgc ccaatatgtc agccaaatta aaaaacgcgg cattaaatct 459181 cataaaggat atgtcaatga cgcgaaggtg tcagaccacc acgcgattat cccgaccgaa 459241 gagccgctcg ttctcagcag tctgagtgat aaagaacgaa agctgtatga cctgattgcg 459301 aaacgtttcc tggctgtatt aatgcctgca ttcgaatatg aggaaacaaa ggtcatcgca 459361 gaaatcggcg gagaaacctt tacggcgaaa ggcaaaaccg tgcagtcgca agggtggaaa 459421 gccgtttatg atatggcgga agaggatgat gagcaggagg atgacagaga tcagacactt 459481 cctgcgcttc aaaaaggcga cacacttgcc gtccgcacgt taacggaaac aagcggccaa 459541 acgaagccgc ctgcccgctt taatgaaggg accttgctgt cagcgatgga aaacccaagc 459601 gcgtttatgc agggagaaga aaaaggcctc gtcaaaacgc ttggagaaac aggcggcctc 459661 ggcacggtgg caacgcgtgc cgacattatt gaaaaactgt tcaacagctt tttaatcgag 459721 aaaaaaggcc aagatatttt tatcacatct aaaggaaaac agctcctgca gcttgttccg 459781 gaggatctga aatcaccggc cttaacagca gaatgggagc aaaagctgtc tgcgatcgcg 459841 gccggcaaat tgaaatcggc tgtttttatt aaagatatga aggcttacgc tcaccaaacg 459901 gtaaaagaaa tcaaaaacag cagccaaacc ttccgacatg acaacattac gggaacggca 459961 tgtccggaat gcggcaaaat gatgctgaaa gtaaacggca aacgcgggac gatgctcgtg 460021 tgccaagatc gtgaatgcgg aagcagaaaa acgattgccc gaaaaacaaa cgcacgctgc 460081 ccaaattgcc ataaaagaat ggagcttcgc ggccaaggcg agggccaaac ctttgcgtgt 460141 gtgtgcggtc accgtgaaaa gctctctgta tttgaaaaac gaaaaaacaa agacaaagcg 460201 cgtgctacca aacgggacgt atcctcttat atgaaaaaac aaaataaaga tgagccgatt 460261 aacaacgcgc tggcagaaca gctgaaaaaa ctcggtttgg ataaataata aaaaaacctg 460321 tgcctatcgc acaggttttt tattggactt aggtcctgtt ttcttaatgt tcaaaaaggg 460381 aaaaaaaagc tagcaatctg catttttttt cttttatagt aaatgtactt tgtaacatgg 460441 cagtcatatt ttcgtctata actatttgtg agcgtctgat ttgcttcagg cgacaaaggg 460501 ggatttgcct gtgaggcatg tactaattgc tgtcatctta ttcttcttat ctatcggact 460561 ttccgcaggg tgtgctgaag ctggaaacaa gacccaaaat cagtcggcga cagaagtgaa 460621 tgccagcccg ctccagccgg cggaatattt catctatcac aatttaatga atgacaaagg 460681 gctgatcaaa accgattttt cagaccagcc ttcttacttg tcggaatctc tcggactgtg 460741 gatggagttt ctgctcagca aaaatgacgc accacatttc caggatcaat atcagcatct 460801 gactgattca tttctgatga gcaatcactt ggtgacgtgg aagattcaaa atggccaagc 460861 gagcgggacg aatgcgctga tagatgatat gagaattatg ctgtctcttg accaagccgc 460921 cgcaaaatgg ggccgcagcg actacgcgca aacggctagg gatatcggca cgtctttgaa 460981 gacatacaat atgaacaacg ggttttttac agacttttac gactcacagg ccgcttcaaa 461041 ggatgtgacg ctttcatacg tcatgcctga tgccttagct gtcttaaaga agaatggaat 461101 catagacgaa gaaacagaac agcggaatgc caatgttctc tattcagctc ctttaaaaaa 461161 tggctttctg ccgaagacat acagctcgga gacgaaggaa tacacatatg atagtgaaat 461221 caacctgatt gatcagcttt acgctgcttg gcatttgccg gaaggggatg aaaaagcatc 461281 tgttttagcg gactggatca agcaggaatt tcagaaaaac ggaaagctgt acgggcggta 461341 ttcggcatat acgaaggagc ctgccgtcca atatgagtct ccatccgtat atgccttagc 461401 cgtattgttt ttgacaaaac agcatgaaaa cagttctgtc atcaaagcca tatatgatag 461461 aatgaatgac tttgaaattc atgatccggt gaaatcgtat tatggaggct atatgagcgg 461521 cactcagacg cattcatttg acaatctgct gccgctgtta gccgaaagga agctttttaa 461581 tgaaaatatc attcagtgaa tcacaaaaat tatttgctta tttttcaggg ctcatcgcgg 461641 ccctgtcttt gtttatttat tatgtgtcag cccagcaatc agaaggtgct ctgatccttt 461701 gcatcacatt tggcgtcatc gccgcaggca tctggttcgg cccgatttac gcgctggcag 461761 tgaccttaat cgtactcttt gttctcggca ccttaatgat gtttttccag actggacaga 461821 catcgctctt tccggctgag gaagggctgc gaatgcttgt cgtgtgggga atcgcgcttt 461881 tgctgttttc ttttatttct ggaagaatcc acgatattac agcagagctt cggcgctcaa 461941 tgacacggct tcaatccgaa attaaaagct atgttgctgt tgacagagtg actggttttg 462001 ataacaagca aaggatgaag ctggaacttt cagaagaaat caagcgggcg gagcgctacg 462061 gcaattcttt tgtgtttttg ctgctccata tgcattattt caaagagttt aagtctttgt 462121 acggtgaaaa agaaacggac cgcctcttcc aatatgtcgg tcagcaaatc aggacaagcg 462181 ttcgggaaac ggataagaaa ttccgtccct ctgacgagcg tatcgggatc gtgctgacgc 462241 acacgcctgc tgaacatatg ccggccgttc tgactaagct gaagaaacaa ttggatacat 462301 atcagctgga aaatggaaag tatgtgtcgc ttacgttcca cgtttgctat ttgccctacc 462361 gcaacgatat ccaaacagct gatcaatttt tagaagaact ggaaaacgag atgatgatga 462421 atgaactata aaggaatcac attgctatgc gtcatgatgc ttctattttc agctattgcg 462481 tcttttcccg tttctgcgca agcgaaagat caggatgccg gcattctcat catctactca 462541 accttggacg gcaaagagtc gtcacaagtc aaaatgctcg atttgcttgc gggccacttt 462601 acatcccatg tgacagtcaa aaaagattca gacgttgaag cgtcggattt caaagggaaa 462661 gaccatgtga tttattacgg ccaaacgaaa agaaagctca gccaaaaatt gctgtctctt 462721 atcagcggcg tgaaaaaacc ggttgtcgcc attggctata acgcaggcca aatcagccaa 462781 ttttctgggc tttcattagc ccgcaaagaa aatgtgtttc aggttcacag caggtcagaa 462841 aaggccgatg tgtctctgga aagcgggctt aacgtgctga gtgtatcagg cctgaaagga 462901 acggcgcttt acaccttcaa agcggatgaa ggcacaacgc attcttttat atggaaaaca 462961 aaaaaaggga atgtgtacat tggattaaca aatttgttaa atgacaattt gatcgtggcg 463021 aaacagctca gagaagcttt cggagagaag gcggggacga cgttattgta tttgcgtctc 463081 gaggatatca gcccgatgtc tgatgaaaaa ctgctgcttc aagccggtac atacctgcat 463141 aagcggcata ttccttttat cctggcggtc attccggttt acttgaatcc ggaaacaggc 463201 gacaaagtgt atttgtctaa tcaaccgaag atggtcaagg tgctgaagaa gctgcaaagc 463261 atgggcggca gtatcatagt tcacggctat actcacgctt atcgctacag tgaaacagga 463321 gagggatttg aattttggga tgcaaaggcg gatcagccga ttacatccgg aaatgccgaa 463381 gaccccccgt ccattttgga gaaagaacag gacttcccga acgaacaagc ctatcacagc 463441 tatcttgaac catttcggga aaaggaagaa acgtatacaa aacaaaaact gacgcgtgcc 463501 attgaggatt tgacatcatc gggtctttac ccgctggcgt ttgaagcgcc gcattacacg 463561 atgtccgaat atggctatca aatcgcctcg cagtatttta caagcatttt cggccaggtc 463621 cagctcagca gcacaacatg gaaaacatcc ggtgcacctc cgtttgtgac tgctccttcg 463681 atgctgcacg gaatgacgct ttatccggaa acgatcggct ttgtcgacac atcgaagcaa 463741 aacccgctcg gtgagatgga ggagcatatc tcccagatga ttgattttga aggcggagta 463801 gccggaggat tttatcaccc gtaccttggg atgaaatatc tgcctgagct ggttgatcag 463861 atggaacgca ttccagacag tgaatggctt gatttaaaga aaacgaaaca aaccgtcaaa 463921 acagacaaag tggaaattca tacaagcggt gacggaacga ttcaggtgaa aaacggcgta 463981 agccccattt acgagttttt cgatcatcac cggcaaaccc ctctggaaaa ggcgttatgg 464041 attctctccg ctgttgtgct cttatttgtc atcatgtttg tcagttatac gttttacttg 464101 agagccacat tgaaaaaacg aatttttaag gagagaagaa gccttgggta atacgctgtt 464161 ctttatctcg ctaagtttaa tatgggttat gcttctctac cacatgttcc tcatgcaggg 464221 cgggtttcgc cactatatga ccttcgaacg gaatatcccg aagtggagag aaaatatgaa 464281 ggaactgccg aaggtcagcg tcctcatccc ggcgcataac gaagaggttg tgattcggca 464341 gacgctgaag gccatggtca acctttatta tccgaaggac cggctggaga ttatcgtcgt 464401 taatgataat tcatcagacc ggacgggtga tatcgtcaat gaattttccg agaaatacga 464461 tttcatcaaa atggtgatta cgaagccgcc aaatgcagga aaaggaaaat cctctgcact 464521 taactcgggt tttgccgaat cgaacggcga tgtgatctgt gtgtatgacg ccgacaacac 464581 gcctgagaaa atggccgtgt attacctcgt gctcggcctg atgaatgacg aaaaggcagg 464641 cgccgtggta gggaaattcc gcgtcatcaa tgcggcaaag acgctgctga cgaggtttat 464701 taatatcgaa acgatctgtt ttcagtggat ggcccaggga ggcagatgga agtggttcaa 464761 aatcgccacg atcccaggca ccaacttcgc gatccgcaga agcattatcg aaaagctcgg 464821 aggctgggat gacaaagcgc tcgctgagga tactgagctg accatccggg tatataatct 464881 cggctatcac atccgctttt tccctgccgc catcacgtgg gagcaggaac cggaaacatg 464941 gaaggtatgg tggcgccagc gcacccgatg ggcgcgcggc aatcaatatg tcgtgctcaa 465001 atttttggcg cagtttttta agctgaaacg aaaacggatt atctttgatt tgttttattt 465061 tttctttacg tacttcctgt ttttctttgg cgtgatcatg tcaaatgcga tttttgtagt 465121 gaatttgttt tatgatttgc atttgtctgt tggatttttg gcaatgattc tctggatttt 465181 ggcgtttttc ttatttatga cagaggtcat gattacgttg agcattgaaa aaacagaaat 465241 gaacaagcaa aactttttta tcgtatttct catgtacttc acatactcgc aggcatggat 465301 tgtgcttgtt atctactctt tattcgtaga aatcaagcac cgtttattca agcaagaggt 465361 caaatggtac aagacagaac gatacaatca acataaaagc gggtgacctt tttgaaacaa 465421 ataatgattt ttctcacaag cttcatgctg ctggcgatga ctggacaaac ggctcttgcc 465481 aaagacgtac aggtcagcgg ttcgctcctt gggaaaagca gccaagaaca agccaaacag 465541 caggtgctga caagcgagct gattacactg tatggatcaa aagacagcgc agagctgacg 465601 tatcagatcc cggcaggcgc ctcttcgggc aatcagcaat tggtaatcga atacgaggca 465661 tcaaatcttt taatttctcc atcatcgtta acggttgtca ttgatgatga accggtcaag 465721 acgttaaagc ttgatggtga ttccaaacgg aaaacagtga agctgaatct gaataaaagc 465781 cagtctgcgc aaggctatca caacgtatcg ctgaaattct acggcgtaat gaaagagggc 465841 gtgtgcgtca gacaggatac atcaggcaac tggatcaaaa tttatccgga cagccggctg 465901 acacttgctg acagcagtga agcgaaggga acgtcgctgg accattatcc gtatcctttc 465961 gcccaatctg gaaatacagc ggaagaaaca gctatcgtca ttccggataa cccaagttca 466021 gcagaaatag aagctgctgt taaaacagaa ggctatttga aaacggtgga cagcagtgtc 466081 agtattgcgt atgtcacgga atctgaactg aaaaaaatcg ataagccgac gattgttatc 466141 ggcgtggaca agcattggaa cggcaaagtg aaaaaactgt tgaaacaagc cgggctacag 466201 gcaaaaggag aaaaccttct gcttgcggag cgggtgctga aagcagaggg caaacagcag 466261 ccggttctgt ttgcgcaagc ggcgtccgag gacgcgctca caaaaaaaat cagcgtgatg 466321 acagatcaga catatacagg ccagctcagc ggcgatacac tttcaatcag caagcttcag 466381 cagactgaaa aaaaagaaag cgataagctg acccttgaga attttggagc gggtgatatc 466441 acaattggag ccgacaaaac atcttcagca cattattttt atccggcttc ggctgtttta 466501 gatgaaaacc aatcggcgaa gctgtcgctt aaactgaaaa agtctgaaac gattcaagcc 466561 tcaacggctg aaaacgagtc agcctctcag gctgcagaac tgaaagtgat gatcaacggc 466621 cagccgcact cggtccggct tgatgaatta ggaaaagaag ataaaaacgg attctatcat 466681 gtcacagtga aagtggaccc taagctgctg caaaaaaacc gctacattga tattcagttc 466741 gtcacgaccg gtttaaagga aaacaaccct tgtaacacca ctgatgaaga aaagtgggtt 466801 tttatcgata aaaacagtac attatcatac gccatcaaag gcatgtcccc gtcagcggat 466861 tttcaagagt ggccgctgcc ttacgccgga aaccaggatc aaacaacgtt aatcgtgctt 466921 cctgacaccg taagccaatc gaagctagag gagctttctc tcgtaacaga atcctttggc 466981 aacgaagcac agcattcata tacggtaaag aaatcatctg acgttacagc aaatgatgcg 467041 aaaggacgaa acctcatttt cataggaggg atcaatcaat tttctcttct gaaggagaaa 467101 tcatcagatc tgcttgtgcc gcaggaaaag aacggctcgt ttgatgtatc tagtttcgag 467161 atgctgaatg agacgacaaa acaagtggta tttacccaag catcggtttg ggattcacgc 467221 tatacaatgg ctgtctttgc accgtcaaaa ggagatggca cggctgtcac aaaagagatc 467281 atcagttatc tgaacagcaa cgatgagtcg gcaaccgtcc ttaatgaaac aaacagccag 467341 caggtgttta caaaccacca gcagctcaaa tcggaaacaa acagttccga tgcagaacaa 467401 ccaacacagg atcatagcca gaaatggatg tatattggtg tgctggcact cattatggtg 467461 gttgcggcag tgttcatttg gattgccgta agacgcaaaa aaagaaagac agatacagaa 467521 taaaacagag gcgattttag cctctgtttt tttatttttg gtaagtaaat tccatttgtg 467581 gaacctgtca ttttattttt ttctctcagc caataagcct ctttacaacg tgcgggaacg 467641 ggagtatgat ctcttttaga aaacaaatcg cttaatctga aatcagagcg ggggacccaa 467701 tagaacggct ttttgccgtt ggggtgaatc ctttttaggt agggctaact ctcatatgcc 467761 cgaatccgtc agctaacctc gtaagcgttc gtgagaggag atgaatgaaa cctgtgttcg 467821 atgttatggc acaggggcat ccgtttgcct ctgtgttttt tgttgttcat ttttgaatgc 467881 aaatcgcata cagagacatc atagcagaaa ggactatcat caacatgtga gagcaagaca 467941 ctgatggatg ttttattgtt ttaattgaaa aatgagaaat taaaagggga agacatcgat 468001 gtatcattca atcaaacgtt ttttgattgg gaaaccacta aaatcccaag cagctggaga 468061 gcaaaaactg acgaaattaa aagccttggc tatgctttcc tcagatgcgc tgtcatctgt 468121 cgcatatggg acagaacaaa ttctaatcat tttggcaaca atcagtgcag ccgcattttg 468181 gtactccatt ccgattgcgg ttggcgttct catcttgctg ctcgcactga ttctttcata 468241 caggcaaatt atttacgctt atccgcaggg cggcggggcg tatatcgttt ctaaagaaaa 468301 tctcggtgaa aaaccgggat tgattgcggg cggttcattg cttgttgatt atattttaac 468361 agtagcggta agtatttccg caggcacgga tgccatcacg tcagcctttc ctgcattgca 468421 tgattatcat gtgccgatcg ctatttttct cgtgttagtg attatgattt tgaacctgcg 468481 cgggctttcg gaatcagcat ccatacttgc ctacccggtt tatctgtttg tggtggcgct 468541 tttggttctc attgcagtcg ggttgtttaa acttatgaca ggacaaatag accagccagc 468601 ccatcataca tcgctcggca cacctgtagc cggcattacg ctatttttgc tgcttaaggc 468661 tttttcctcc ggatgctcag cgttgaccgg ggttgaggcc atttctaatg cgattcctgc 468721 attcaaaaac ccgcctgcgc gaaacgcggc aagaacgctt gcgatgatgg ggattttgct 468781 ggcgattctg ttttccggca tcacggttct cgcgtacggg tatggtacgg cgccgaaacc 468841 tgatgaaaca gtggtttcac aaattgcgtc cgaaaccttt gggcggaatg tgttctacta 468901 tgtcatccaa ggtgtcacat cgcttatttt ggttcttgcg gcaaatacgg gattctcagc 468961 cttcccgcag cttgccttca acctggcgag agaccagtat atgccgcgaa tgtttacagt 469021 caggggcgac cgcttaggct tctcaaatgg gattatcttt ttaggctttg cctccattgt 469081 tctcattatc ttattcgggg gacagacgga gcacttaatc ccgttatatg ctgtgggcgt 469141 atttattcca tttacgcttt cacaaaccgg catgtgcatg aaatggatca agcaaaaacc 469201 aaaaggctgg atcggaaaaa tgctgatcaa ctcctgcggc gctctgatat catttatggt 469261 tctatccatt ctgtttgtga cgaagtttaa tgtcgtatgg cctgtgttaa tctttatgcc 469321 tatcgtcgtt ttgctgtttt ttgcgattaa aaatcactat actgcggttg gtgaacagct 469381 tcgcatcgta gacaaagagc cggaagaaat caaaggcacc gttgtgattg tgcctgtggc 469441 cggtgtcacc accgtcgtgc aaaaatcgat tcactatgcg aaatcactgt ccgatcaggt 469501 gatcgccgtt cacgtgtcat ttgacagaga acaggaaaag aaattcgaaa aacgttggga 469561 agagcttaat aacggagtgc gtctcgtgac gcttcactcc tcttacagaa gccttgtcca 469621 tccgtttgat aagtttttgg aaacagttga ggcaaaagcg aagaaggagc agttttccgt 469681 tatggtgctg tttccgcaat ttataacgaa aaaacgctgg cacaccatcc ttcacaacca 469741 atcggccttc ctcctcagag tccggctgtt ctggaaaaag gacataatgg ttgccacact 469801 gccgtatcat tttaaaaagt aaagctctag gaccaaggga atcaccttgg tcctttttag 469861 cgggaaaagg aggtatgggg gtgtatacac aaggtgcttt tgtgatcgta ttgaacgaaa 469921 gtcagcaaat tctgctggtg aaacgaaaag atgtccctct atgggatttg ccgggcggca 469981 gggttgatcc cggggaatcg gctgaggaag cggcagtgcg ggagatattg gaagaaacgg 470041 gatacaatgc agcgctttct gcgaaaatag gtgtttacca aaggccaaag tttcaagatg 470101 aacagcatct gtttttcgga agcattacag gcggacaagc aatggctgac ggcacagaga 470161 cagcgggatt aaagtgggtt tccccggggc gtttgccgct ttttatggtg ccgaatcgaa 470221 aaaggcagat caatgatttc aagaacggcg ctcaagatgt aaatgtcacc gtcaaggata 470281 gcgggttgct cgcggcgatc gacctgttga aaagaagact gggcaagtga ttcaggtctc 470341 cgggttttaa agcctttctc ctgtggtatt gaaaaaagga aaaaggagga tacgttatgg 470401 cacacaaaac tgcaggacaa gcaatgacag agctgcttga gcaatgggga gttgatcatg 470461 tatacggcat ccccggagac agtataaatg agtttatcga agaattaaga cacgaaagaa 470521 atcaactgaa gttcattcaa acccgccacg aagaggtagc ggcactggca gccgcggctg 470581 aagcaaaact caccggcaag atcggagtct gtctgtcaat cgcagggccg ggagcggtgc 470641 acttattaaa tggtttatat gatgctaaag ccgacggcgc ccctgtgctg gcgattgcag 470701 gacaggtttc ttctggcgaa gtcggacggg actatttcca ggagattaag ctggagcaaa 470761 tgtttgagga cgtggccgtg ttcaacagag aggtacatag cgcggaatca cttccggatc 470821 tcttaaatca ggcgatcagg accgcctaca gcaaaaaagg cgttgcggta ttgagcgtgt 470881 cagatgattt gtttgcggag aaaatcaaac gggagcccgt gtatacttca ccggtgtata 470941 ttgaagggaa cctagaaccg aaaaaagaac agctcgtcac ctgcgcccaa tatattaata 471001 acgctaagaa accgattatc ctggcagggc agggaatgaa aaaggcgaaa cgggagctct 471061 tagaatttgc ggacaaagcc gccgctccga tcgttgttac actcccggca aagggtgttg 471121 ttcccgataa gcacccacat tttctcggca acctcggtca gatcggaaca aagccggctt 471181 acgaggcaat ggaggaatgt gatttattaa tcatgctcgg aacgtcattc ccgtaccgtg 471241 attatttgcc tgatgacacg ccggcgatac agctcgattc agacccggca aaaatcggaa 471301 aacggtatcc ggtgacagcg ggccttgtct gtgattcggc tctcggtttg cgcgaattga 471361 cagagtatat tgaacgcaag gaagacagaa gattcctgaa tgcctgcaca gaacatatgc 471421 agcattggtg gaacgaaatt gaaaaagatg agacagaggc aacaacaccg cttaaacctc 471481 agcaggtcgt ggcccgtctt caggaagcgg cagccgatga tgcggtgctc tctgtagatg 471541 tcggcactgt gacagtctgg atggcgcgtc atttcaaaat gaacgcgaat caggatttca 471601 tcgtttccag ctggcttgcg acaatgggct gcggcctgcc gggagcgatt gcagcgagct 471661 tgtccgaacc ggaacgccag gcgatcgccg tctgcggtga cgggggattt tccatggtca 471721 tgcaggacct tccgaccgcc gttaaatata agctcccgat cacagtcgtt attttaaaca 471781 acgaaaatct cggcatgatt gagtacgagc agcaggtcaa aggcaatatc gactatgtca 471841 caaaacttca aaatgtcgac tatgccgcat ttgcagaaag ctgcggagca aagggcatca 471901 aagtgaccaa agcggaagag cttgcgccgg cttttcatga ggcgctgcac tctgaccaac 471961 cggtcgtagt ggatgtcatg attggaaacg aaccgccgct tcctggcaaa atcacctacg 472021 ggcaggcgaa aggctttagc aagtacatgc tgaaaaactt cttcgaaaac caaaaatttg 472081 aaatgccgtc actgaagaaa agtttgaaac ggttatttta aaaaaacagg ggccctaaga 472141 gcccttgttt tttttttttt ttttggaaac aaatgtattt tcagcatgtt tgaattcata 472201 aaatgatcgg tatatgtatt aggaactgat ttcgccatac tcgaaacaga caaaaggaca 472261 aatgcatctt gtttcaaagg aagatgcatt tgtccttgca tgcttattct tatcaaatct 472321 tacagaactc ttctcataat aggttatttt tcttttttct tcagcccgaa gaagaaagga 472381 aaagcagaac cgaccaagaa ggtgccgaat aaaaacatgc cgccgataaa cacgtggaaa 472441 tttgtgtgtc cggccgtaaa cgccgtgatt agggaaatga tactgagcac gatcatggca 472501 atgccgggcg cgactctcat ttttcccttg gatttatggg cagcaacaga acataaaatg 472561 ccgataacaa taggaacaat ccacaaataa aacagaataa atactgacat catcaaaact 472621 ccgatttttc ttctatcata acaaatttct gtcaaaaagg gtatcaatga gcttttgcgg 472681 aaaaataaaa accggcttta gaagccggtt tttttatcga aacgtatcta caattaaaaa 472741 cacattcaaa gcaacgatca atacagcaat cagccaagac accactgtga tccatttggc 472801 gttgatcaga gatcccatga tccgtttatt gcttgtaaac ataataagcg gaatgagggc 472861 aaaggcgatc ccgaaggaca gcacgacctg gctcagtacg agagcggtcg tcggattaac 472921 acctgacgcg atgatcaaga tcggcggaat gatcgtgata aaacgccgta catacagcgg 472981 aatgcggtag ttgataaatc cttgcataat cacgtcgcct gaaagtgtgc cgacagacga 473041 actggataga ccggcaacga gcagcccgat cccgaacaaa gccgcagaca tagggctgac 473101 aagatgtccg aattgctgaa atgcgacgtc gagatcctca acaaacaggc cgtttttgaa 473161 gaataatgcg gcagccacaa tcagcatact tgcattaata gcccctgcaa tcagcatcgc 473221 tattaaaata tcaataaatt caaacctaaa gatttttttc cgttctgcat cagttttgcc 473281 aaccacccgc cgctgtgtaa gggcagagtg taaataaatg gcgtgcggca taacagttgc 473341 gccaagaata cccgctgcaa gaagcacact gtcggtgcca tgaaacgccg ggacaaaaag 473401 gcccttcatc actgacacgg catcaggctt tgcgaaaaag gtctgcaacg caaaggcgat 473461 cacgaccaca aacagcatac cggcaatacc tgcttcaagt gagcgataac cacggcgctg 473521 aagctccaat atcgcgaaag aaccgatcgc cgcaataata gacgcttcaa gcatcggaat 473581 gccgaacagc aaatacagtc ccagagccgc tccgataaat tccgccagat cagttgcgat 473641 aatgaccaac tcgccctgaa tccataatcc gatcgagaca ggcttcggga attcttcacg 473701 ggcaacctca ggcagatttt tgcctgtcgc aataccgagt ttggcggata gggattgaat 473761 taaaagcgcc atgatattgg aaaataagat cacccataag agcatatatc cgtatttaga 473821 acccgccgaa atattcgttg cgaagttgcc gggatcaata taggcaatgg ctgctataaa 473881 tgcagggccg agaaaaggga gcagccctct gaatcctctg attttcccgt caagcgcatc 473941 ttggacggct ttggaacggg gagattgtgc tgtgatgtcc ttgttcatca tgtctcacct 474001 gaattctgtt tgtttttgcc gtacaacaaa gagtttcctt aaggcaaatt attttatcta 474061 catcatatga ccatcccggt ttcttgtcaa ccgaaaatgt tcaaaataca cttctgaatt 474121 tttccctgtt atgtaacatg atatgtaggg attcgtgata aggtcccata taaaaagaca 474181 tcgtttcatt tcgaaacgat gcctcctgta tctaatgagt ctaggcttcc ttccgcagcc 474241 cgcggaatat aaggcccagc aagaacacga agatggctgc cccgatgatg gccgggaaaa 474301 tagcaaagcc ggcgaggctc ggtccccatg tgccaagaag tccgtgccca atccaagcgc 474361 cgatcagccc ggcaatcata gagccgaaaa ttcctcccgg cagccggttt cctacaatgg 474421 cgctcccaat taatccgata acaattgcaa caactaatga aaccaaaaag ctaagcatca 474481 tgatcacctc tcataaatga tttaccaatc aataaccgct cctgatcatt tcgaaacact 474541 tgaaagcata ttcctttatg atcctgtttt aatctttctc tgcacactgc cgtcagctaa 474601 atgaacaatg acctcagtgc ctttatgcgc cgcgatttcc tttgcccgtt caatcgcttc 474661 tttctttgta tccttgattt cagacacacg tttggcgccc tcggctttga ctgcccagcc 474721 ttttttatgc ttaataacat gctctgcttt attcatgagc tcggggccgc tgccgctgct 474781 tggatcagca tcgcgttctg tctcatcatc atgcgtcagg aaatcatcaa tttcatctgt 474841 agaggcgttt tccgcccatt ccttcgcttt gcttgtcgca attggaatcg cgcgcccttc 474901 ctcatagcct tcatcaatca tcgcattcgc aatgtctatc gccttttttc tcaccggctt 474961 ctcaagattt tttaatgaag caggataatc cttcatcgac caaggcatgt ctatcactcc 475021 ttttcctttt ataaaaatgg tacccgcagg tgaaaaataa aaacgcatcc gaaaaaatga 475081 aggtatacta tatagtagaa aaaacggaag ggaagtgcgg gttgggtgcc aacagaacga 475141 aaagaagact tacatcagca attaaaagag atagagaaat gggaaaaaga tcagcaaaaa 475201 gtctggtttt gggaaaagct cagccgtctc ccgtttcaac tcctggacaa gctgacacca 475261 gaattcatcc agaaaaagat cggcaagctc ttggatgagg tcggcagctt tgttcaaaca 475321 ggcggacagt acctgacatc tgaaaaacag attatcagga tgtttcaaaa gaaactgccg 475381 gaggagatct ttgaatcgct ggaggacatc cggaaagcgc ctcttcctgt catggatgaa 475441 attgcggaag gaatgggcaa aaacagaacc aacgcagcaa ccgttcaagg cgcgacaacc 475501 ggtgtgggcg gcgtgtttac gctggcggca gacattccgg cagtgcttgg cttatcacta 475561 aaaacattac aggatatcgc agtcgcatac ggctatgacc caaaggagaa aaaagaacga 475621 gtcttcattg tgaaatgcct gcagcttacg tcggctgatg ttgtcggcaa aagatcgatt 475681 ttgcaggaat taaaacacta cgatcaagac cgtacatata agaatgtcgc ttctcaaatc 475741 caaggctggc gagaagtcgt tttgggctat cgagacacgt ttggctggaa aaaacttttc 475801 cagatagtgc cggttgccgg aatggttttt ggcgccgctg ccaatcgctc aacattaaac 475861 gacattaccg agacaggcat gatgctgtac aaaaagaggc gcattcttga acgactgaaa 475921 gaaacagaac gagagatgga atagcagaaa gcagacggac accgcgatcc gcctgctttt 475981 tttagtggaa acatacccaa tgtgttttgt ttgtttaaaa gaattgtgag cgggaataca 476041 acaaccaaca ccaattaaag gaggaattca aaatggcaga caataacaaa atgagcagag 476101 aagaagcagg tagaaaaggc ggagaaacaa caagcaagaa ccatgacaaa gaattctatc 476161 aagagattgg tcaaaaaggc ggagaagcca ctagcaaaaa ccatgacaaa gaattctatc 476221 aggaaatcgg cgaaaaaggc ggagaagcca ctagcaagaa ccatgacaaa gagttctatc 476281 aagaaatcgg tgaaaaaggc ggagaagcca ctagcgaaaa tcatgacaaa gaattctatc 476341 aagaaatcgg ccgaaaaggc ggagaggcaa caagcaaaaa tcatgataaa gaattctacc 476401 aagaaattgg ctcaaaaggc ggaaacgccc gcaacaacga ctaatcaaaa gcataaaggc 476461 agacaacctg taaataaaaa agcgatccgg cacatcagct ggatcgcttt tttttggaat 476521 cttctcaatt tatgccgcta ttgagataca ataagtgaaa aaggggtttt cgctaatgtc 476581 caagatgcaa aacttgctcg ccatcgcaaa tgaagtcaaa gaaaagcacg ccaatttttc 476641 aatctcagag gtcaacgacc actgcgtgcg ccttgcggtg tttacgggag aatatgactg 476701 gcaccatcac cctgactcag acgaattgtt tattgttctt gaaggggagc tgctgatcga 476761 ttttaaggac aaagaaaccg cggtgctcaa agcaaatgac agcctgctga tccctaaagg 476821 cacggttcac cgcacacgct cttacgtcag aacggtaaat ctctgtgtgg agcataaaca 476881 agccgaaacc gtcatcatag aggagcagcc atgctaatca aaaagatgat atgtgaagta 476941 gatgctgcaa acgctgaagc atttgcaaaa gcgcagtcac agtgggaagc gttatcgcat 477001 ataagcggct ttatcaaaca ggccggcggc tggcgaaaaa cgatagacga gccgctcacc 477061 gcagaaatca tcagtgtatg ggaaaacaga gaagcctatg atcattttat ggagaacgaa 477121 catgacagca tatacgagga aaacgatcag aaggctgtaa ttctttcgat agaggtgacg 477181 gtgtacgaag aggataaacc gttcgttcac gatctgttac ataaccccga tatccggtac 477241 gaaccaaact ggacggttct gaaggcataa tcaaagccca aaacatcatg ttttgggctt 477301 gtctctttac tcgcgtcccg gaagtgtatt atgaacaaaa ggcggtgctg gttttaactc 477361 cggtttttct ccaaacgttt ttgcttcttt cacatattca aaggcttctc cgtccggcgc 477421 tttttcattc agccagtttt gctcggcgct tacttcgcct tcagagaaat tgataagctg 477481 atgtgagaac tcttgttttt cgagcgcttt cgggaatgta cccggcacaa ccggaccttc 477541 ctgtgcttct aattctttaa tggcggcgag ccattggttc tggtgcatcg tgtcacgcgc 477601 cagcaggaag ctgagcatat ctttgacgcc tttgtcatcc gtcatttcaa acaggcgtgc 477661 gacctgcaga cggccctgag attccgcatt caggttggcg cggaagtctg ccagcaggtt 477721 tccgcttgct acgatataac cgccgctcca aggtacgcct gtactgcttt ccggcatggc 477781 gccaagtcct gatacaatcg catggtgagg gttcatgccg cctaggatgg agccgatgac 477841 cggatcttca gcagcttttt cctgctgatc aagaggggca tcctcaagaa gtctggcaat 477901 catcgttgcg atcatttcaa catgcccgag ctcctcagtt gccgtatcca tcagcaagtc 477961 cttgtatttt tcatttcctc ttgtgttcca gccttgaaat aagtactgca tggcaactga 478021 aatttctccg aattgcccgc ctaaaatttc ttgcattttt ttagcgaata atggatctgg 478081 acgatctggt ttagcaggat gctgcagcat ttttgtgtgc ttaaacatgt acccatctcc 478141 tttttcgttt atctcttttt atatttccga tcgatagaaa gataaacgaa aaacagcgta 478201 tcgagatggg aactatgaat cttttcgcag ctccaacagt tcccggatca gctcccggcc 478261 aaagatgggc tcatactgcc ggtaaacagg gtcaagacgc ttcatccatt cttgtttctc 478321 tttatctgac agctcataaa tatgtatagc agaattcttt ttgatttctt ccagctgctc 478381 cttgttcatt tgttcggcat acgtttcatt ccactccgtt gtctccttca tcgcttcagt 478441 caaaatgcgt cttgtttctg gtgtttgcgc cttccagaag tgttcatcag tcatgacagc 478501 gtagccgaga taaccgtggc tgcttattgt caaatagtcc tgaacattat aaaatttttt 478561 agaatagatg tttgaaattg tattttcttc gccatcgact acattgtttt ctaacagctg 478621 aaaggtagaa ttgaaggatt cctgatgagg tgttgcgcca agcagcttga actgatcctc 478681 aatcacatcg ctttgcataa tgcgcagatc ctgccctttt aagtcatccg gtgttttgac 478741 cggcccttga tttgttgtga tttgcttaaa gccgttcgtc caataggcca atcctttcaa 478801 ttggtttttc tttagagaat caaacagctg tgtgccgatg cttccgttca gccctttttt 478861 gacggcgttg taatctgtaa atgcatacgg cagatccagc actccccatt caggcgagag 478921 catgccgagc ttcgatgtgg agggggcgat aaattgaaca tcgccgtttt gcaatgcttc 478981 aatttcttca atgtccgagt acaggcttcc attcggaaat acttctattt ttatttttcc 479041 gcctgatttt tcgttcacca gatcagcgaa tttattggcg gccagccctt ttggcgtatt 479101 ttcagcaacc acgtggctga atttaaacac gatttgatcc tgcaggcctt cctggtcgtc 479161 atcataaaca atctttttat tgccggtatg atcatggaat ccgataaata aagcggttgc 479221 aattccagcg atcatcagtg cgagacatgc aagcaaactc ttcatgaaaa gccctcccct 479281 atgttaagga taatgggggc tatgacattc gtaaagacct gaaaggagaa gctgatgaac 479341 aaaaagaagc tctcaatccg ttggaaaatc acgatcttat cctatatact cgtcattttc 479401 tcctttttga tcggcggcat tgtgctcatc ggcaacattc agcatacaga ggagcgggag 479461 ctgaaaaagc ggctgatgaa tacggcccgg acggtgtcag agatgacaga agtgaaagaa 479521 gccttggcgc gaaaaaaaca aacagaagcg gttcgccatg cggttgaaga aatcaggatg 479581 attaatgaag cagactatat tgtcgtcatg gatatgaatc acatccgata tacgcatcct 479641 gtcagcacaa gcattggcaa gaaatcagaa ggtgcagacg aggaggcagc ttttgcggag 479701 cacatttatt tctctgaagc aaagggcgag atcggcacgg cggttcgcgc tttttatccg 479761 gtaaaggatc aagacctgaa ccaaataggc gtggtgcttg tcggaaaaac gctgccgggg 479821 atcgctgaca tcctgcttca tttaaagcgt gatatcgcct tcatcgttgt gctgacactc 479881 ggctttggcc ttgctggttc ctttttgctg gcccgccata tcaaaaaaca aatgtttcag 479941 cttgaacccc atgagattgt ccgaatgtat gaagaacgga cagcgacgtt tcactcgatg 480001 aatgaagggg tgatcgctat tgacaatcgt ctcgtcatta cgatcttcaa tgaaaaagcg 480061 aaacagatct ttgaagtgca gggggatcta atcggcaagg tgatttggga ggttctcaag 480121 gattcgcgcc tgcccgaaat cgtggagcgg aacaaagcgg tttataatga agaaattcgt 480181 gtcagcggta aggtgatcat gagcagcaga attccgatcg tcatgaagaa aaaagtgatc 480241 ggcgccgttg cgatttttca ggacagaacg gaagcggcca agatggcaga ggaattgact 480301 ggtgtcagaa actttgtgga ggcgctccgt gtccaaaacc atgagcatat gaataagctg 480361 cacacgatcg ccggtctcat ccagctgggg aaatctgaaa aagccttgca gcttgcattc 480421 caggcgtcaa ctgagcagga aaatgtgact gaatttctgc accgctcgat tcaaaatgac 480481 gctgcggcag gccttctatt aagtaaaatc agaaggggaa gagagctcgg cattgctgtt 480541 catatagatg aaaacagcag tcttcagcaa tttcccgagc atgttgatca gcatgatatt 480601 gtcgtgcttt tggggaatct gattgaaaat gccttcggct catttgaaac cgttcaatct 480661 gaagacaaac gaattgacat tagtatcgaa caaacagatg atatccttgc tattttaata 480721 gaagataacg gctgcggaat tgaaccgaca catatgcctc gcctttatga caaaggtttt 480781 acggtcaata aaactggcgg cacaggctat ggcctgtatc tagtgaaaca aatcatagac 480841 aaaggatcgg gcacgataga agttgattca catgcggggc aggggacatc tttttctatc 480901 gtttttccaa tgaaggggga ggaagcacag catggctcgt aaagaatgga aggttctgct 480961 cattgaagac gatccgatgg ttcaagaggt caataaggat ttcattacaa ctgttaaagg 481021 cgttactgtc tgtgcaacgg caggaaacgg agaggaaggc atgaagctga ttaaagaaga 481081 acagccagat ctcgtcattc tcgatgtgta catgccgaaa aaagacggca tcaagacctt 481141 gcaggagatc agaaagcaaa agcttgaagt ggatgtcatt gtcgtctccg ctgcaaaaga 481201 caaggaaacg atctcactca tgctgcaaaa cggggcggtt gactatatct taaagccgtt 481261 taagcttgag cgaatgagac aggcactcga aaagtacaag caatataaac aaaaaatcga 481321 agcgaatgat acgctgtccc aggaacagct cgatgcgatc ctgaatattc cgcagcaggc 481381 cgtacaggat ctgccgaaag ggttgaatca cttcacgatg aatgaagtca ctgctttttt 481441 gaaacagcaa accgcatccc tttctgctga agaggttgcc aaggcgctcg gcatcgccag 481501 agtgacagcc agacgatatc ttgattactt agaaaaaacc gggatcatca aattggacgt 481561 tcaatacggc ggagtcggcc ggccggtcaa ccgctacgtg ttaaaaggat aaacctgaga 481621 ccaaaaagac caaaatgtcc gttatgatca taaacttccc cagactgtat gaaaacgcta 481681 tcattctagt aagaaagaca caaaaggcga ataggacagg gggatgaagg atatgaaact 481741 gtttaaaaat ttaacagttc aggtcataac cgcggtcatc atcggggtca ttgtcgggct 481801 ggtctggccg gatgtcggca aagaaatgaa accgcttggt gatacattta tcaacgctgt 481861 taaaatggtg atcgcaccaa tcattttctt cacaatcgtt ctcgggattg caaaaatggg 481921 cgatatgaag aaggttggaa aagtaggggg aaaagcgttt atctatttcg aggttgtcac 481981 caccctcgca ctcattatcg gtttatttgt cgtcaatatt atgaagccgg gtgcgggtct 482041 tgattacagc aagcttgaaa aaggagatgt atcacaatac acgcaaaatg gcggtcaggg 482101 aatcgactgg attgaattta ttacacacat tgttccgtcc aacatggttg atgccttcgc 482161 aaaaggggac attttgcagg tcttattctt ttctattctt ttcggagtgg gtcttgcggc 482221 attaggcgaa aaaggaaaaa gcgtcattga tttcttcgac aaggtttctc acgttttttt 482281 caaaattatc ggctacatta tgcgtgccgc gccaatcggg gcattcgggg cgatggcgta 482341 tacaatcgga cacttcgggc tcgattccat caaaccgctg gcaagcttaa tgatgtctgt 482401 ttatattacg atgttcctgt tcgtatttgt tgctttaaat atcatctgca agctttacgg 482461 attcagcctg tggaattacc ttcgcttcat taaggatgag cttttgatcg tgcttggcac 482521 aagctcttcc gaatcggtgc ttccgcgtat gatggataaa atggagcgct acggctgttc 482581 caaatccgtt gtcgggcttg ttattccgac gggctattcg tttaacctcg acggcacatc 482641 catctattta tcaatggcga ctgtcttttt ggcacaggtg tttggagtag acctcagcat 482701 cggccagcaa attacgatta tcctcgttct gatgctgaca tcgaagggag cggcaggtgt 482761 gacgggaagc ggatttatcg tccttgcctc aacgctgtca gcgctgcagg tcattccgct 482821 ggaggggctt gcactcctgc tcggggtcga ccgtttcatg agtgaaggaa gagccattgt 482881 gaacctgatc ggaaacggaa tcgccacgat cattgttgcc aaaagcgaaa atgaatttga 482941 tgaagcaaaa agcatagagg ctgttgaagg catgaaaaaa atgaaaacag cagtctgaaa 483001 aaagaacggc ccatccatgg gccgtttttt taattgttta agaattatta aggtaaggac 483061 agagacctca gcattttttt gttatataat ttacaaatgg atactatatt gaatgaagga 483121 cgtttgtcct aacaggagtg tataaatggc cgctttagtt aaattttttc agcacccggg 483181 agtaaggcgt ttctccatct ttgtcgtgtt aactggtgtg ttatatctat ttaagagcat 483241 gatcaactta atattgctta ccttcatttt cacatttcta atggatcgtt tggagcttgt 483301 cgtgcggcag tttgtaagcc agttcttccg cgtgagccag cgggttgtca ttacgtttct 483361 ttacatgttg ctggctgtgc tgcttacagt cgggggcttt gtgttttatc cggtcgtcgc 483421 ggcgcagatc cagcagctgg taaagcagat taaacatatt gcgtatcatc ctgacagcat 483481 ccctttcttt gatgagatca ccagtgtctt cggagatatt aacatcagtt catatgtcaa 483541 agagggcttc aatgtagtgt atacgtatct ggccgatatc agcacattcg gcttgcaggt 483601 cgtgatggcg ctcattctta gcatgttttt cttatttgag aaaaaacggc tttctgaatt 483661 catggcgaaa tttaaaacga gcaaacttag ggtcttttat gaggagattg cttttttcgg 483721 aagcaaattt gcaagaacgt tcggcaaggt gctcgaggct caatttatca ttgcgctcgt 483781 caactgtatt ctgacgttta tcgcgctttg gattatgcat tttccgcagc tgtttgggct 483841 ttcgattatg gtgttcttcc ttggattgat ccctgtagca ggcgtcgtca tttccctgat 483901 tccgctcagc attatcgcct acagcactgg cggtggaatg tatgtgctct acattgtcct 483961 tgtcatattc gccattcatg cgatcgaaac ctatttctta aatccgaagc tgatgtcggc 484021 gaaaacagag ctgccaatct ttttcacctt cacagtactc attttctctg aacacttctt 484081 cggcatttgg ggtttaatta tcgggattcc gatctttgtg tttctccttg atattctgga 484141 tgtcaccaac aaggaagata ggtctaaagg accccgagag aatagcgata aaaagtagtt 484201 taaaatcgaa taatgagtgt gcctcgatct gccggcctgc ctgttcaggg catggaatta 484261 agactcggaa tcggagcttg gcattgcctt gcacagtggt gaacacaaca ggtgacaatg 484321 cttgtcatca gtacggaaac tgaaaagaac aaacagtcgg agcaaacgct catcatcggt 484381 ttaaccaaac atttggaagc aacaaatgct ataatacaaa cagtgcctaa tgttgggcac 484441 tgtttatttt ttgtcgaaaa aggaggaagg ctttatggct gagccgattt tacatattga 484501 aggcctcgat aaaaaaattg ggtctaaaca gattttaaaa cagatcagca tggacgtcat 484561 ggagggtgaa atcatcggcc ttctcggtcc gaatggttcc ggaaaaacaa cactcatccg 484621 tatcatcgtc gggctgttga aacaaaacag cggaagcgtg acaatcagcg gattccagca 484681 tgatacagag tttgaaaaag cgatggaagc ggttggagcg attgttgaga accctgagtt 484741 ctatccgtac ctgacaggct gggaaaacct caagcacttt gcgaatatgc acaaaaaaat 484801 agcggatgaa cggcttgatg aagtggtgga acgtgtcggg ctgacgtcag cgattcatga 484861 taaggtgaaa acctattccc ttgggatgcg ccagcgtctg ggaatcgccc aggcaattct 484921 tcaccggccg aagcttctca ttctagatga accgacaaac ggcctcgatc ctgcggggat 484981 gaaggatttt cgggatcata ttaaggaact cgcagaaatg gaaggaacag ctgtcctgtt 485041 cgccactcat ttattgcgcg aggttgaaga cttgtgcgac cgtgtcatca tcattcaaaa 485101 aggtgagatc aaagcggaag tcagcttaca aggaaccgat caaaccacag aaaaagcgat 485161 tatagaagtg cagccgcaag aaaaagcgct caattggctg acaggcaatc aatatcaagc 485221 tgagagccaa gacgggacga ttgtagttga ggtggcaaaa gaaaacatac cggagctgaa 485281 ccgatcactt gtcggacaag atctgaatgt attttccatt acgccttaca cgcagtcact 485341 ggaagacgaa tttataaaag cgacaacagc tcatcaagag gagggagaag agcttgtcta 485401 aattaatttg gaatgaacat atgaaacttt ttaatcggaa ggtcactttg gtttctctta 485461 tcctgatggc tgtctttcaa ttcttcatgg cattgatcat taaacggatt gtcatcagtg 485521 ccggaacaga tgaaaacttc atcggctatt tatcgtatac accgagcctg aacattttgc 485581 tgcaggcttt aacgatcgta attgcagcaa caattgtttc gatggaattt gataaaaaga 485641 cgatcaaatt tttgctcatt cgtccggtta aacgccaaaa ggtcttttgg tcaaaattaa 485701 tcacagtcgt gatggtcagc ttctatttgt atttggcata ctacattctg gcattattat 485761 tcggtctctt gttttttggc acatcggtga ctgcggaatc aaagacattg ctggtcaaca 485821 ccttggcgct gatcgggtca aactggcttg aagctgtaat gatgggatta ttcgggctgc 485881 tttgttcttc gctgttccgc aatagcgcgg tagcagttgt tgtttctttt gtcgttttat 485941 acggagcgag tacacttgtt cagctcatga agttgtttga aaacaagtgg ggcagctttt 486001 tgctttttgc gaacactgac tttacgcaat acagaagcgg agagacagcg ttgttttcag 486061 gcatgacgcc attgttttca attggaattc tcatcataca tgccatattc ttcatcgttg 486121 ttggctggtg gtgcttctgt aaacgggatg ttcgggtcta aaggcaagga atgacatttt 486181 tgtgaaaaag ctcacgtaaa tcaatatcat ttgatatttt ggtttatact aaaggtactg 486241 acggaggtgt ctcgattgag gaactttatt accgctttac cgatcgtatt gctgcttgga 486301 ttctcatttg tgtcattcat gtttcagttt gaacatcttg tttatttcag gctcgcgctt 486361 gggttgtttt ctctcgtggg actgtacatg atatataaaa tgaagacggg catccgctat 486421 tttatcatct atctgtatgc cagctggatt gtgttggccg cagtgaccgc ttttgaagag 486481 ccgattttct caagcttttt ctttggcggc ctggtgatga cgatgggtta cctgacatat 486541 atgctgattt atctcggcat gaaacaagac cgggatgcaa atcctgtgta atcgcgctgt 486601 tcccttgggg aacggcgtgt ttttctatac tgggcaaaag gttaacagtt gcggaaaaat 486661 ggcaggaaat ctataataca tattaaattt atcggaatta aaactggggg gctgccggat 486721 gtcattattt atacaaaacg atcaacagcg gcaatggatg gagaaaatcg gacggattgc 486781 ggatgaattt cagcaaacag ctgctgaaga tgacgaacag ggacgttttc ctgcagagaa 486841 aatacaaaaa ctgcgtgatg ctgggtatac agcattaaca ttgccggcat ctcatggcgg 486901 agggggcatt tctgtttacg atatgctctt gtttcaagaa cggcttgcac ggggagatgc 486961 tccgacggct cttagcatcg gctggcattt gagcgtgatc ggggagcttg gagaaggcaa 487021 cagctgggat gaagacgtat ttgcatttgt tgccaaggaa gtccaaaacg gagccgtcat 487081 taacagggcg gcgactgaag cgaaaaccgg aagcccgaca agaggagggc gtcccggtac 487141 acacgccgtc aaaaaggatg gcaaatgggc agtgaacggg agaaaaacct ttacgacgat 487201 gtcacaagct ctggattatt ttttagtaac cgcatggatt gaggacaaac aaacaacagg 487261 cgtgtttctc attcataaag atgatcccgg cttgtcgatt gaagaaacgt gggatatgat 487321 ggcgatgcgg gcgactggga gccatgacct tgtactgaac gaagtaatgc ttgatgagaa 487381 taagctggtg gaactgcttc aagggcctcg tggagctaag ccgaatggct ggctgcttca 487441 cattcctgcg atttatcttg gtgtggctca agctgctcgt gactatgcag tgcaatttgc 487501 atctgagtat tctccaaaca gcttgaatgg accgatcaag aatgtcccgg ccgtacagca 487561 aagaacaggc gaaatggagc ttgaactgct caatgccaga cactttcttt tccatatcgc 487621 tcaattgtat gacgatccgg tgcggcgtcc acacttgacc agcgagctcg gtgcggcgaa 487681 acatatcgtc acaaacgctg cgctgtctgt tgttgataaa gcgatgagaa ttgtcggggc 487741 caaaagcctg gaacgaacca acccgcttca gcgctattac cgtgatgtgc gcgccggtct 487801 tcacaacccg ccgatggatg acgccgtgat acacaagctg gcagctgaag cgtttgagtc 487861 ataaaaaaaa gagccttacc ggctcttttt atgtattgtt ttgctcttgc agattttttt 487921 gatgcttgcg gtcgatcctg tcataaataa cgttcatcag ctttggattg cccataatcg 487981 cctctttgtt ttcctggatc agctgttggt aagttttcac tttacgcttc ggcatgctcc 488041 ggcgccctcc tgacatgttt gtattcactt tctaactccg tcagcgacaa ttcatacaga 488101 tgacgctttg actttttgta tataccattc tgtattaaca gatgaatgag ctgttttttt 488161 ctgatttctg cagactgagg tgtcattgtg tcaccaacct ccaatcaaac gatattgata 488221 atcattatca attaacttca gtatacaatg tccgcaatag cctgtaaaga tgaaaagagt 488281 cctattcttg gccaatttac aaacattcaa caaatcgaca aaaagtttcc cgggcaataa 488341 tttgctgtcg aaatattccg cttcattgaa cgcaccctgc tatttttcat gttttgaacc 488401 atactatgta atagaatgga ggctggtatt caatggagcg gacagaaaat ctgaaaaagg 488461 gagaaaaagg ggcgctcctc aatatttttg catatgtcat ccttgctgtt gtaaagctag 488521 ttatcgggat tctatatcat tctgaagcgc tgagagcaga cgggttaaat aatggaacag 488581 atattgttgc gtcagtagca gtgctgatag gattgcggat ttctcaaaga ccggctgaca 488641 gcgatcatcc atacggccat tatcgggctg aaacaatttc gtctcttgtt gcgtctttta 488701 ttatgatggc agtcggcatt gaagtgttaa tcggcggagg aaaagcgatt gcgggcggca 488761 caacggaaac gccaaatctt atcgcggcat ggacggcgtt aggcagtgct gtgtttatgt 488821 atggcatcta tttatataac aaaaggctgg cagcgtccat taaaagctct gccctgatgg 488881 cagcggcaaa ggacagcagg tcagacgctt ttgtaagtgc cggcgcgttt atcggtgttt 488941 tttcgtccca gctgaagctg ccgtgggttg atccggtaac ggcttttatc atcggcatca 489001 tcatttgcaa aactgcgtgg gatatcttta aagacgcttc acattcctta acagacggct 489061 tccatttaaa agatcttgag ccttacaaac agaccgtcgg caggatcgaa aatgtgcatc 489121 gcctaaagga tgtgaaagcg aggtatttag gcagtacagt tcatatcgag atggtgatta 489181 cggttgatcc gaagcttaca gtagaagaag gccatggagt ggcggatgaa gtagaagaca 489241 aaataaaaca tgaacacgat gtcactcatg ttcatgttca tgtagagcct gacgacataa 489301 aataaggctg tttaacgaat tagcttatat gttcagataa aaattcagtc acttcttcag 489361 gcgttttggc attggcgctg tgaaggtgag ctgttttttc accgttcttg aaaataagca 489421 ggctgggaat gcccattact tggtattttt cagccaggtc aggaagctcg tccttattca 489481 gctcatacca gtcgttttgg ttgtattctt ccaaaatatc gccgatgaac atattcatgc 489541 gtgtgcagtc tgggcaccaa tcagcataaa actttacaat gatttcttta tcagattgaa 489601 tcagttcatt aaattgttcg tttgttgtga tttttttcat atgtcacatc tccttttcaa 489661 tgccatttta atataaaata aaaaggaatt acatacaaat gcattcaaca tcagcatgcc 489721 caaaaataat tagatcattt tccggtgaaa atgataagat agtaaagatg aattgtagtg 489781 gggggagtat ccattgaaaa caagtctagg attagtgtac ggaggaaagt cggcagaaca 489841 taatgtttcc ctgcagacag ctctggctgt aatcaaagcg ctaaatactg agaagtttga 489901 tatacatccg atttatataa cagaaaaagg cgaatgggtt agaggcgccc gtttaactga 489961 acctgtttca aacgtgaaaa tgcttcaatt tgagcaagga ggcagtgctt tttctccagc 490021 tgccctgaac caggagatgt ttccgcagga agcgtcacag caaaatgaag ccatcgacgt 490081 cgtattcccg ctcctccacg gaccgaacgg agaagacggt acgatccagg gaatgctcga 490141 gctgttgaac attccttatg tcggcaacgg agtgcttgct tcctcagctg gcatggataa 490201 agttgtcatg aaacatttat ttgcgcaggt tggccttgct caggctaaat acgcagcttt 490261 ccttaagaaa gactggactc gttctccgaa agaaagctgt gaggaggttg aacaggaatt 490321 aggctaccct tgcttcgtaa aaccggcgaa cctcggctca agtgtcggaa tcagcaaatg 490381 ccgaaaccgt gaagaactgc aaaaagcgtt tgagcttgct ttccaatatg accgcaaagt 490441 cgtcgttgaa gaaggaatta acggccgcga gatcgaaatc ggcgttcttg gaaatgatga 490501 tcctaaatgc tctgttgtgg gagaaatcgc accgaagaca gatttctacg attacaaagc 490561 gaaatatgag gatggagata ctgatctgat gattccggcg attgtgactg atgaggaata 490621 cgcaacaatc agtgatatgg cgatcaaagc gtttaaagcg atcgacggtt caggactcgt 490681 cagagcggac tttttcctga cagctgacgg cgaagttctg atcaatgaag tcaacacaat 490741 gcctggcttt acacctttca gcatgttccc gttgctctgg aaagaagccg gagtggaata 490801 tgctgacctg attgaacagc ttgtggagct tgcaaaagaa cgccacgctg aaaaacaatt 490861 gattaagcat acattctaat gaagaaggac actgccggta aaagggcagt gttttttccc 490921 gtatatacaa aagaaagaga gggaccttac ttgattaagc gaacagtaaa aaacattgcc 490981 gaaatggtta aaggcacact agcaaatccg caatatgaac aaacagtcat tcatggagtg 491041 gcaaccgata caagaaaact ggaacaacat cagctcttta ttccgctgaa aggggaacgt 491101 tttgacggcc actcttttgt ggagcaggcc tttgaagctg gtgtagcggc tgttctttgg 491161 gatcggtcag taccaaatcc gcccgagaat cacgccgtca ttttagtgga cgataccctt 491221 actgcacttc agcagcttgc aaaagcttat ttgcaggagc ttggcacgcg tgtcatcgga 491281 gtaaccggaa gcaatggcaa aacgacaaca aaagatatga ttcacgccgt attggggacc 491341 cagtaccgtg tccacaaaac tggaggaaac ttcaataatc atatcggttt gccgctgacg 491401 gttttagcga tgcctgaaaa tacggagatc gccgtattgg agatgggaat gagcgccaaa 491461 ggagaaattg acctcttgag ccgactggca aacccggatg cggcagtgat tacgaatatc 491521 ggcgaatcgc atatgcaaga cctcggctct agagagggca tcgcggaggc gaagcttgaa 491581 atcataaacg ggcttaaaga agacggagtg ctgatttata tcggggacga accgcttctt 491641 caaaatgcat acagctgcca gacgaaaacg tacggtacgg gaacgcataa tgattatcag 491701 cttcaggatg tcagccagag tgaggaagga acccatttta caatcaaagg gatagaaaac 491761 acgtttttta ttccaatact cggcaagcac aatgtgatga acgccatggc tgcaattgct 491821 gcaggggctt attttggcat cgcgcctgag gatgcggcaa aaggactgag cggcctaaag 491881 gtaaccggga tgaggcttga actcatcaaa acagacagcg gcctttcgat aatcaatgac 491941 gcttataatg cgagcccgac ttccatgaaa gctgcaattc aattgacaga aagccttgaa 492001 ggctacggca aaaaaatgct cgtgctcggt gatatgcttg aactcggcga tcttgaagaa 492061 acgttccata aagagtgcgg cgctgtgatc agccctgata aaattgaccg cgtctttacg 492121 tacggaaaac tgggagcttt tatcgcggaa ggcgccctga aacactttga gaaagaccgc 492181 gtcagccatt acactgagaa aaaagatctc cttcaagctg tgaaggaaaa cgcatcaaaa 492241 ggcgatttga ttttattcaa agcgtccaga ggtatgaagc ttgaagaaat cgttaaagat 492301 ttaatagaga gcccgctttc ataagaaaat attttgcgaa aaaacgcata ttgcatcata 492361 aaataacctg atatgcaaac actaatgtat gccggccgaa aattatgtat atctggccgg 492421 ctgcggctat gatacaatat atataggtta tttcgcgata cgaacatatt cgtccggact 492481 tttcatcgtg acccgaagtt ctccgctgga ttcttgggag cggatggagc agcagccggc 492541 atattcgaga tgccgatctg cttctcatct tattgaaaaa caaatagtgt aatggtaaga 492601 taaaacttaa agtaattcgg gctttgtata cggatggatc ctgtccttct tgtctaaagg 492661 gcagttttat aagtggtaaa tcacgacatt actgaaacag caattagaag gagtttgaat 492721 aatttgacta taacgtttca agattttaat ttaagttctg atctcatgaa agcaattaat 492781 cgtatgggat ttgaagaagc aacaccgatt caggcacaaa cgataccgct cggactttca 492841 aataaagacg tcattggaca agcgcaaaca ggtacaggta aaacagctgc gtttggtata 492901 ccccttgttg aaaaaattaa ccccgagtct cctaatattc aagcaatcgt aatcgcgcca 492961 acccgtgaat tagccattca agtatctgaa gaattgtata aaatcggaca agataaacgt 493021 gcgaaggttc ttcctattta cggcggacag gatattggac ggcaaatccg ggcgttaaag 493081 aagaatccga atattattgt cggaacacct ggacgtcttc ttgaccacat caaccgccgc 493141 accattcgtt taaacaatgt aaataccgtt gtaatggatg aagcggatga aatgctgaac 493201 atgggattca ttgacgatat tgaatctatc ctttcaaacg tgccaagcga gcatcagaca 493261 cttctgttct ctgccacaat gcctgcgccg atcaaacgca ttgcagagcg cttcatgact 493321 gagccggaac acgtaaaagt aaaagcgaaa gaaatgacgg tttctaacat tcagcagttc 493381 tatttggaag tgcaagaacg taaaaaattc gatacactga ctcgccttct tgatattcag 493441 tctcctgagc ttgcgatcgt attcggacgt acaaaacgcc gtgtcgatga gctggctgaa 493501 gctctgaacc ttcgcggata tgcagctgaa ggtattcacg gtgacttaac gcaggcgaaa 493561 cgtatggttg cgcttcgtaa atttaaagaa ggcgcaatcg aagttctagt cgcaactgat 493621 gttgccgctc gcggacttga tatctcaggt gttacacacg tatacaactt cgacgtgcct 493681 caagatcctg aaagctacgt tcaccgtatc ggaagaacgg gccgtgcagg aaaaacaggt 493741 atggcgatga cgttcattac accgcgtgag aaaagcatgc ttcgcgcaat tgaacaaaca 493801 acaaaacgca aaatggaccg catgaaggag cctacacttg atgaagcgtt agaaggtcag 493861 caacaggtta ctgttgaacg tcttcgcaca acaatcagtg aaaacaacct gaacttctac 493921 atgacagcgg cagctgagct gcttgaagat catgatgcag taacagtggt tgcggcggct 493981 atcaaaatgg ctacaaaaga gccagacgac acaccggttc gcttaacaga cgaagcgccg 494041 atggtcagca aacgctacaa gaaccagcgc tcttctaaac gcagagacgg tcaaggcggc 494101 ggctaccgcg gcggaaaagg gaaaagcaac aaccgttctt cctatgacaa aaagcgttca 494161 aacgatcgcc gttcttcagg tgacagacgc cagaaaaaat cttactaatt tgatcgattc 494221 agagcccaaa acatgatgtt ttgggctttt ttatgttcgt gatttgttat tcagcaaact 494281 ttcagctgac ggaagccatt tttctctgta tgcttaagaa tgaaaccttt ctgtaaaaga 494341 gacgtataaa taacgacgaa aaaaagggag gtaggtattt ttgagagagc agccaaaaaa 494401 ccaaatcagt ccagacggat taaaggtttg gcgacttcaa gagatcatca tatccgctgt 494461 ttgcttgctt attgtcattg cagttgcagt gttaagctat tattttcatt ggccgtactg 494521 gatcagcggc gtgctcggcg ctgtttggct gctgggatcg attgtgacgg tctttatcat 494581 tccgaaggtc cgtcataagg tgtggcgata tgaagtccat gaacatgaaa tagatattca 494641 gtcaggtatt tttgtggtga cacgtgtgat tgttccgatg gtcagagttc agcacgtcga 494701 tacgtcacaa gggccattat taaaaaaata caacctggca acggtgaaaa tttccacagc 494761 cgcgaccgtt cattcgatcc ccgctttaga gatggaggaa gcggatcggc taagagactc 494821 catttcccgt ctggcgaggg tgactgacga tgatgtctga accgaaacgc ctgcacccgg 494881 tggcagtcat tttgaattta tgccatacca ttattcaaac gataaaaaat atcattctgc 494941 cattcttttt tgtgtatatt gtcaattcaa accatactgt ccgtttttac ggagccattg 495001 cgctcggtgt gctgttcatc tggcttgtag cggcaagcat tatcaaatgg agaaggttta 495061 cctatcgaat tgaagatgat gaatttagaa ttgaagaagg cttatttgtt acgaaaaaac 495121 gatacatatc gattgatcgg attcaaacaa tgaatacgag cgcgggcctt gtccagcaaa 495181 tctttaagct tgtgaagctg caaattgaaa cagcaggcgg aggcaaggag gcagaagccg 495241 ttctttctgc tatttctgtt gaagaagcgg aacgcatcaa agaagctgtc tttaagaaaa 495301 aagcgcaaag acgagaaaat gaacttgatg aagaacggct tgaagctgaa gaggagttgg 495361 atccgtccgt tgaggtgcaa gagcactatc gcatgaacgc gaaagaattg ctcatggccg 495421 cttctacctc cggcggaatc ggagtcatta tctccgctgt atttgcactt atttcccagc 495481 ttgatgaagt gctgccgatg gattggttat tcgataaatt ttccttcctt cagcacgcca 495541 gcatcggtat ttatgcggta ctcattttta tcggtttatt tatcgcctgg attttcagca 495601 tcgcgggcat gatgtttaga tacgcgaact ttcaaatcat aaaaaaagag caggaactgg 495661 tgatttcaag gggaattatt gaaaaacatc aagtcacgat tccgctgcga aaaatacaag 495721 ccattaaaat caaagaaaat atcattcgcc agcttttcgg ctttgtaacg gtgtccatcg 495781 tcagcgcagg aggcggcgac cgggaaaaag aagaaggcgc tttgaccatt ctctttccaa 495841 tgattcataa aaaaaagctt ccgcacatgc tccgaacatt tacgccggaa tacacgctgg 495901 aagaaaactg ccgccgcctg ccgcggcgcg cgttgaaacg ctatttgttc cgttctgtca 495961 ttttttcact ctttttgatc atcccgttat gtatcttctt tcagccatgg ggctatctgt 496021 cagtgatcct gctgccgata gaattgctct tcggctatct cgcgtataaa gaggctgcat 496081 ggacgatcaa cggggaccgt cttcagctga cgtctagatt tataggcaga acaaccgcca 496141 ttgtactgaa aaaacgaatg caggtctgca agttcagcca atcctatttc caaaagaaag 496201 gccgcttgta taccatttct acttcggtga aatcatcgag ccatatggaa gagttaacgg 496261 tgagggacgt aggtgaagag gatgcagcct tcattttaaa gtggtactca tatgaaaaag 496321 cggacggtta ataccgccgc tccagcgtgt cggcaaaccc tcgcattcgt tgtcaggact 496381 gcgcttcggt gctcaatgcg aagtggatca acggctaaat tctcaggcgt cctgcctaaa 496441 cgccgtcgtc atcacatcct gtgaaagtcc gctcctatgc tcgtccttcc tagacttcat 496501 gggttttcaa tcacgctgaa aagatgacaa aatcctaaaa tgaaaaccat tttaggattt 496561 tgtcaacaat ctgaagcggc ggttaatacc gccgctcttt tttttgcacg cataaaaacg 496621 aaagaagaaa cccgccgcat agtccaaaca aatgggccat catgttaata ttggagttga 496681 taaacgacat gagaacggca aatgcgagca gtgtgatgat cattttggaa tgctcctgcc 496741 caattaactc attgcgaaaa agaaccataa acaggtatac gccaaatagc ccgaaaatgg 496801 cgcctgaagc cccgacatgc acgtaatcaa gcggctctgt aacataagtg ccgatattgc 496861 cgatgatgcc ggagccggcg tatacaagaa ggaaacgcgc ttttcccagc atgcgttcca 496921 aagccggggc aaataaaaag atggacatgg aattaaacag cagatgtgtg aaaccggcgt 496981 gcagcaaaat cggtgtgata agccgccacc attcaccgtt tgcgacacct agattatagc 497041 ctgtgacggt atccctccat aacacgactg aatgggcagg aagtgaaaaa aacagccaga 497101 gaacagcttg caaagccaat ataaaggtga caacggggta aagcctgata aatgtttgaa 497161 aattttcagt ccgtataaac attccgagcc ccttttcttc attttggtat atctatagta 497221 acacgtttat gagacaaacc atttaaatag tacgtacgca aaggaggtta tcatacatga 497281 tttacggcat tgggctggac attaccgagc ttaaacggat cgcctctatg gctgggcgcc 497341 agaaaaggtt tgccgagcgg attttgacgc gaagcgagct tgaccaatac tatgagcttt 497401 cagagaaaag aaaaaacgaa tttctcgcgg gcagattcgc ggcaaaagaa gcgttctcga 497461 aagcatttgg caccggcatt gggaggcagc tcagctttca ggacattgaa attaggaaag 497521 accaaaatgg caagccctat atcatttgta cgaaactgag ccaggccgcc gttcacgtat 497581 cgatcactca tacaaaagaa tacgctgccg cgcaggttgt gattgaaagg ttgtcaagct 497641 agtctgcata ttagggaaac cccactcata tatttgatag tgcattaagg gagacaagtt 497701 gtttgaggct tttatggtac gcatctgttc tgcctaaacg tgtaccgagc gtaccgttaa 497761 agtcaaacaa gcgatttctt ccttttacat caattgagaa aaaggggttg aaaaaggtga 497821 gaaaaagctt tgttttgctt ttaacgggac tgcttgctgt tcttattctt tctgcctgcg 497881 ggcaaaaaac acagcaagat attgtggccg ggttagatga aaaggcgaaa gaatacacct 497941 cgtacaaagc aaaagcgaaa atgaccatcg agacagggag tgagcctcaa gtatacaatg 498001 tggaaatctg gcacaaaaag ccgtctctgt acagggttta tttagaaaat ccgaaaaagg 498061 accaaaacca agtcatttta cgaaatgaaa acggagtatt cgttctcacg ccgtctttaa 498121 ataagagctt cagatttcaa agcgattggc cgaacaacag cagccaggtt tatctgtttg 498181 aatcgctcgt aaaggatgtt caaaacgatt cggatgcagt tttcacagcg aaagaaaaga 498241 aatacgtatt tgaaacaaaa acaaactatc agcataacaa aatgctgccc acgcaagaaa 498301 tcacatttaa caaaaaagat atgagcccgt catctgtcaa agtgatggat actgaccgga 498361 aagtgatggt caaagtagaa ttcagcagct ttgaatttaa taaacaattt gataaagaat 498421 catttgatga aaagaaaaat atgacccttt ctcaaatgga tgtcgccaca agcgcaaagc 498481 cttccgatac atttgcggtc aaaacgccgc tggaactgcc gcttggcgtc aagctgcttg 498541 aagaaaaaga tatatctact gaagacggga agcgcatcat catgacgtac ggaggagaaa 498601 aatcatttac gttaattcag gaaaaagccc agattgccaa ggcttcctcc tccgttacgc 498661 tgaacggcga accggtaaat ctcggctaca ccatcggcgc cctgtcggat gcatcattat 498721 catggacata tgacggcgta gattaccttc tctcttctaa agatctttct aaagaggaaa 498781 tggtgacagt agcgaaaagc atgcagggac aatcatcgaa ataaccgcca aaggccaaac 498841 atgatttggc ctttttttcg ttagacatcg tttcccttta gcctttaatt ttagtatgat 498901 atgtaaatga tattgaataa aagctaggaa gtgtcgtaat gagcacaaaa cctttttaca 498961 gagatacgtg ggcggaaatt gacttgtccg cgataaagga aaatgtcagc aatatgaaaa 499021 aacatatcgg tgaacatgtc cacttgatgg cagttgtgaa agcaaacgcc tacgggcatg 499081 gtgatgcaga aacagcaaag gctgctcttg acgcaggtgc ttcatgcttg gccgtggcca 499141 ttttggatga agcgatttca ctgcgcaaaa agggattgaa ggcgcctata ttggtgcttg 499201 gcgcggttcc cccggagtat gtggcaatcg ctgctgagta tgacgtgacc ttaacaggtt 499261 attctgttga atggcttcag gaggcagccc gccacacgaa aaaaggttct cttcattttc 499321 atctgaaggt cgatacgggg atgaacagac ttggtgtaaa aacagaggaa gaagttcaga 499381 acgtgatggc aattcttgac cgcaaccctc gtttaaagtg caaaggggta tttacccatt 499441 ttgcgacagc ggatgaaaaa gaaagaggct atttcttaat gcagtttgag cgctttaaag 499501 agctgattgc tccgctgccg ttaaagaatc taatggtcca ctgcgcgaac agcgccgctg 499561 gactccggct gaaaaaaggc ttttttaatg cagtcagatt cggcatcggc atgtatggcc 499621 ttcgcccgtc tgctgacatg tcggacgaga taccgtttca gctgcgtccg gcatttaccc 499681 tgcattcgac actgtcacat gtcaaactga tcagaaaagg cgagagcgtc agctacggag 499741 ccgagtacac agcggaaaaa gacacatgga tcgggacggt gcctgtaggc tatgcggacg 499801 gctggctccg aaaattgaaa gggaccgaca tccttgtgaa gggaaaacgc ctgaaaattg 499861 ccggccgaat ttgcatggac caatttatgg tggagctgga tcaggaatat ccgccgggca 499921 caaaagtcac attaataggc cggcaggggg atgaatatat ttccatggat gagattgcag 499981 gaaggctcga aaccattaac tatgaggtgg cctgtacaat aagttcccgt gttccccgta 500041 tgtttttgga aaatgggagt ataatggaag taagaaatcc tttattgcag gtaaatataa 500101 gcaattaact tacctaaatg gagaattcat aaaacagctt tgcttgaaga gtgaataatg 500161 gtatcattat cactggatgg ataaaagagt cgtatccgta agtttggtgg aggtgtatgt 500221 tttttgtctg aatccagcgc aagaaccgaa atgaaaatca gcttgcccga aaacctagta 500281 gctgaattgg atggtgtagc gatgcgggag aaacgaagca gaaacgaact gatatcacaa 500341 gcagtgagag cgtatgtcag cgaacgaaca actcgtcaca accgtgattt gatgagacgc 500401 ggctatatgg aaatggcgaa aatcaacctg aatatttctt ctgaggctca ctttgcggag 500461 tgcgaggctg aaacgacagt tgagcgctta gtcagcggag gataatcatt tgattgtgaa 500521 acgcggcgat gtttattttg ctgatttatc tcctgttgtt ggctcagagc aaggcggggt 500581 gcgcccggtt ttagtgatcc aaaatgacat cggaaatcgc ttcagcccaa ctgctattgt 500641 tgcagccata acagcacaaa tacagaaagc gaaattacca acccacgtcg aaatcgatgc 500701 aaaacgctac ggttttgaaa gagattccgt tattttgctg gagcaaattc ggacgattga 500761 caagcaaagg ttaacggata agattactca tctggatgat gaaatgatgg ataaggttga 500821 tgaagcctta caaatcagtt tggcactcat tgatttttag acatatttgc aggttgctca 500881 aatagagcaa ctttttttgt tttcaaaaaa cataaacgat ataatagtga aataacgaaa 500941 aaatatgttg ttttttattg ggaggtaagc gaatttgatg tcgaaccaga ctgtatacca 501001 gttcattgcc gaaaatcaaa atgaactgct ccaactgtgg actgacacac taaaagaatt 501061 aagcgagcaa gaatcctatc agctgactga ccaagtgtat gaaaatatat ctaaagaata 501121 tatcgacatt ctgctgctgt ctgttaagga cgaaaatgct gctgaaagcc aaatcagcga 501181 actggcgctt cgagcggtcc aaatcggact gtctatgaag tttttggcta ctgcacttgc 501241 cgaattctgg aagcgtctct acacgaaaat gaatgataag agattgccag atcaagagag 501301 cacggaatta atctggcaga ttgatcgctt tttcagcccg attaacacag aaatttttaa 501361 tcaatactca atctcatggg aaaaaacagt atccctgcaa aaaatcgcgc tgcaagagct 501421 gtctgcgccg cttatcccgg tgtttgaaaa tatcactgtg atgcctcttg tcggaacaat 501481 tgataccgaa cgcgcgaaac gaattatgga aaaccttctt aatggcgtcg tcaaacaccg 501541 ttcccaagtc gtgctgattg acattacagg tgtccctgtc gtcgatacga tggttgccca 501601 tcatattatt caggcatcag aagctgtaag gcttgtcgga gcaaaatgcc tgctggccgg 501661 aatccgtccg gaaattgctc aaacaatcgt caacctgggg attgatttat cccaagttat 501721 aactaagaat accctgcaaa aaggaattca aacagcattg gaaatgacgg atcgaaaaat 501781 cgtttcattg ggggaataac attttgagac atccgaaaat cccgatcttg aaactgtata 501841 attgcttatt agtgtccatt cagtgggaac ttgatgacca gacagcatta acttttcaag 501901 aagacttatt aaataaaata tacgaaacag gtgctaacgg agtcgtcatt gacctgacat 501961 ctgtggatat gattgattca tttatcgcga aagtgctggg ggacgtcatt acaatgtcta 502021 agttaatggg ggctaaagtc gtcttgaccg gcattcagcc cgctgtggca gtgacgctga 502081 ttgaacttgg aatcgcgctt gaggaaatcg aaactgcgct cgacttagag caggggcttg 502141 agacattgaa gcgggaattg ggggaatagc gaatgaacga ccaatcctgt gtaagaatca 502201 tgacagaatg ggatattgtg gccgccagac agctgggacg aaacgttgcg aaagaactgg 502261 gtttcggcac ggtagaccag gctagaatta caacggctat ttcagaatta gccaggaata 502321 tttatttata tgccggcaaa gggcagattg gaattgaaca ggtcgcagac agaggaaaaa 502381 aaggcctgaa aatcatagcg gaagaccaag ggccgggaat tcctgatatc cgaaaagtca 502441 tggaagacgg gttttcaacg tctggaggac ttggtgcggg acttcccggg gtcaaaaggc 502501 tgatggatga attcagctta aattccgtag cgggggaagg aacagagata caagccatca 502561 aatggcttcg gtaggaggta agaacgtgga ttttagggag gttattgagc agcggtatca 502621 tcagctgctt agtcgatata tagccgaatt aacagaaaca tctttatatc aagcccaaaa 502681 attcagccga aaaacaatcg agcaccaaat tcctccggaa gaaatcatca gcattcacag 502741 aaaagtgctg aaggagctgt atccaagtct cccggaagat gtgtttcatt cgctggattt 502801 tttaatagaa gtcatgattg gctatggaat ggcttatcag gagcatcaaa cccttagagg 502861 gatacagcag gaaatcaaat cagaaattga aatcgcggca aatgtccagc agacgcttct 502921 cggaactaaa gttcctcagg aggaagcgct ggatatcggc gccatcagtg ttcccgctaa 502981 acagatgagc ggtgattact accactttgt caaagacaag gaatccatca atatcgcaat 503041 cgcggacgtg atcggaaaag gcattccagc ggctttatgc atgtccatga ttaaatacgc 503101 aatggactct ttgccggaaa cgggcataca cccttctcaa gtgctgaaaa atttgaatcg 503161 tgttgttgaa caaaacgttg atgccagtat gtttattacg atgttttatg cgaattacaa 503221 tatggacaag catcaattta catatgcttc agcgggacat gaaccgggat tctattattc 503281 tcaaaaagac aacacgtttt acgatttaga ggccaaagga ctcgttctcg gcatctcgca 503341 ggactatgac tacaaacaat tcgatcagca tctggaaaag ggcgatatga ttgttttatt 503401 ttctgacggc gtcacagaat gcagaacgga aaacggtttc ttggagcgtc ctgatctgca 503461 gaagctcatt gaggaacata tgtgttcctc tgcgcaggaa atggtcaaaa acatttatga 503521 cagcctcctc aaattgcagg attttcagct tcacgatgat tttacgttaa ttgttttgcg 503581 gagaaaggtt taacgtctgt cagacgaggg tataaagcaa ctagtgattt gaaggaaaat 503641 ttgaggtgat acgaatgaat ataaatgttg atgtgaagca aaacgagaat gatatacaag 503701 taaacattgc aggagaaatt gatgtatact cagccccggt gcttagagag aagctcgttc 503761 ctctggcaga acaaggagct gacttaagaa tttgcctgaa agatgtcagc tacatggaca 503821 gtaccggatt gggcgttttt gtagggacct ttaaaatggt gaaaaaacaa ggtggttcgc 503881 tgaaacttga aaatctttct gaacggctga tccgactgtt tgacattaca ggcttgaagg 503941 acatcattga tatttctgca aagtcagaag gtggagtgca atgaagaata atgctgatta 504001 catcgaaatg aaagtgccgg cccaacctga atatgtggga attataagac tgacgctgtc 504061 aggggtcgca agcagaatgg gctatacgta cgatgaaatt gaagacttga aaatcgcagt 504121 cagtgaggcg tgcacaaatg cggttcagca cgcttacaaa gaagataaaa atggggaagt 504181 gtcaatacga ttcggtgtgt ttgaagaccg tttagaggtt attgtggcgg atgaaggaga 504241 cagctttgac tttgatcaaa agcagcagga tctagggccg tacacacctt cgcacacagt 504301 tgatcaatta tcagaaggag ggctcggtct atatttaatg gaaacgctca tggatgaagt 504361 cagagtgcaa aaccactccg gcgtcaccgt agcgatgaca aagtatttaa atggggagcg 504421 agttgatcat gacacaacca tcaaaaacta cgaaactaac taaagatgaa gtcgatcggc 504481 tcataagcga ttaccaaaca aagcaagatg aacaagcgca ggaaacgctt gtgcgggtgt 504541 atacaaatct ggttgacatg cttgcgaaaa aatactcaaa aggcaaaagc ttccacgagg 504601 atctccgcca ggtcggcatg atcgggctgc taggcgcgat taagcgatac gatcctgttg 504661 tcggcaaatc gtttgaagct tttgcaatcc cgacaatcat cggtgaaatt aaacgtttcc 504721 tcagagataa aacatggagc gttcatgtgc cgagacgaat taaagaactc ggtccaagaa 504781 tcaaaatggc ggttgatcag ctgaccactg aaacacaaag atcgccgaaa gtcgaagaga 504841 ttgccgaatt cctcgatgtt tctgaagaag aggttcttga aacgatggaa atgggcaaaa 504901 gctatcaagc cttatccgtt gaccacagca ttgaagcgga ttcggacgga agcactgtca 504961 cgattcttga tatcgtcgga tcacaggagg acggatatga gcgggtcaac cagcaattga 505021 tgctgcaaag cgtgcttcat gtcctttcag accgtgagaa acaaatcata gaccttacgt 505081 atattcaaaa caaaagccaa aaagaaactg gggacattct cggtatatct caaatgcacg 505141 tctcgcgctt gcaacgcaaa gctgtgaaga agctcagaga ggccttgatt gaagatccct 505201 cgatggagtt aatgtaatga tccaggttga agaaaacgag catattcaaa ctctagtata 505261 tcaactgaat aaagaaggga aatcgatttg cggtgacagt ttttttatga aagctgatga 505321 taaggagtta atttgcgcgg ttgctgacgg actgggaagt ggatcacttg ctaacgaatc 505381 ctctgcagcc atcaaagact tagtggaaaa ctatgcgagt gaagacgtag aaagcattat 505441 cgaacgctgt aatcaggcga tgaaaaacaa aagaggcgct acagcatcta tcctgaaaat 505501 caattttgag caaaggcagt ttacgtactg ctctgtcgga aatgtacggt ttattctgca 505561 ttccccgtct ggtgaaagct tttatcctct gccgatttcg ggctatttat caggcaagcc 505621 gcaaaaatac aaaacgcaca ccgccaccta tgaaaagggt tcaaagttca ttatacatac 505681 agatggactc aacgtacctg atatccgctc ccatttgaaa aaaggccaat cggtagaaga 505741 aatatcgaat tcgctgaaaa tgtatacgac atcgagaaaa gatgacctga cctatattct 505801 cggacagctg tcctaaaaaa ccagaaaaag aagctggaca tccggcttct tttttttgcg 505861 gttgactatt aataagtgcg cttattatac ttaataagtg aacttatcat tctgggagct 505921 tatgggatgt ggaattatga atacacagcg atagctgatg tggatgtggg aaaacctgga 505981 actgttatca ggaaacagaa acaatggatc aatgggagac gggtattgca tcagattctt 506041 tgaaaggaca atttcaaaat ggaacggaag gaacattgct tctgcaagga aaaacaattc 506101 tcttatggct tgagcatgtg gagaaacatc gggcgttttc tgtcatggtc aacatgcccg 506161 catagcaatg taataatgga gttttttcac gtgcttcaaa agcaaaaaga agatttgtgt 506221 atcacatatg gaattgtatt agaaggcgct gaagcaaaaa agtggggaga aatcattggg 506281 actgaactgt ctaaagacat gccgacggct gtcagcaggc ttgtccatct ttacggagga 506341 gtgataaaat gaacacaaat tactggatcg gcgttgtgtc agagcaacat gtattaaaag 506401 gcgctgccgg cggttttgca cagctgtgcc atggaaaaaa agccccgctc gccaaaatga 506461 aagagggaga ttggctgatt tattattctc cgagagacgc atatccagac ggcaaactgc 506521 tgcgaagctt tactgcgatc ggcaaagtaa aaagcggaaa catctatccg tatcaaatgg 506581 ctccgaattt tattccatac cgattagata tagactatta tccatgccat aaaatcggtt 506641 tttacgacat taaatcaaag cttgaatttg ttcaggaaac caagcatctt ggctttttat 506701 ttcgcagagg acactttgaa ataagcaaaa aagatttttt gacaatagca caagcgatgg 506761 gagttaacat aagtggaatg gcactctaaa tttagcggtc cgaacacaag cccgggcttt 506821 ttattatggc aggccacgca aagttggcag cggaaagtag gaaaagcatt ggctgagttt 506881 gacctgaccc acgttcaatt tgttctgctg acctcgtgca agtatatgat tgctcacgga 506941 gaaaccgtca cgcaaaaaaa acttgcaagc ttcagccaga ccaatatcat gatggtttcg 507001 gaggttgtgc ggacgcttga gaaaaaagga tttatcgaaa gaagcaaaaa tccccaggat 507061 aaaagagagg tcctcctgtc tcttacagaa ataggaggag aaaaagtaac agcggctttg 507121 ccaattgttg agaagattga tcaagccttc tttgcagctg cgatgaaaaa agagaatttt 507181 ctgagcggct tacaggaact attgaaacat gagtaaagat acgggcagcg ccagctgtct 507241 ttttttatgt gtttttttcg gtttttgata cactagagaa agaacgacaa aattggaggc 507301 tttggttaca tggaaacgtc agccctttta aaacagcaaa ttgcgaaaga aataggttta 507361 tcacaaaaac acgttgaaag tgtcatccgc ctgcttgagg acggcaatac agtcccgttt 507421 attgcccggt atcgaaaaga gcagacgggt tcaatggatg aggttcagat tcagacgatt 507481 tctgaacgct ggcaatacat acaaaacctg aatcagcgaa aagaagaagt catcaggctg 507541 attgcagagc aggataaact gacagataat ctaaaacgta aaatcgagca atcggtgaag 507601 cttcaggaag tggaagacct ttaccgccct tataaacaaa aacgtaaaac aaaggcgaca 507661 gtcgccaaaa gcaaaggcct tgagccgctt gccgactata tcctgacact tccccaagat 507721 gatcatctgg cagcaactgc agaccaatac atcagcgaag aaaaagaagt gttcacacga 507781 gaagaagcga ttgaaggcgc caagcacatt attgcggaac aaatctcaga cgagccgacc 507841 ttcagaaagt ggattcgcca ggaaaccttc aaaagaggaa ccattaagtc tgcagccgga 507901 aagtcggcag acaccgatga gaaaaatgtg tatgaaatgt attacgagta tgaagagcca 507961 attgcaaaag ttgttccgca tagggtgctg gcaatgaacc gcggcgaaaa agaagacatt 508021 ttaaaggtag cgatcgaacc gcctgcggat cacattaagg cgtatttaga aaaacaaatc 508081 atcaaaaatc gctcaacatc cgtaagagag attttgcagg agacaattga agacagctat 508141 aaaaggctga tccagccggc aatcgagcgt gaaatcagga aagagctctc agaaaaagct 508201 gatgaacagg cgattcatat tttctcagag aacttgagaa agcttctttt gcagccgccg 508261 atgaaaggca aaaccgttct cggtgttgac ccagcctttc gaactggctg taagctcgct 508321 gtgtcagatg agaccggaaa agtcttgaaa attgatgtga tctatccgca tgcgccagtc 508381 aacaaaacaa aagaagccca tgaaaaagtg aaaaagattc ttgagcagta tcaagtcgag 508441 atggtggcga tcggaaacgg cacagcatcc agagaaacag agcaattcat cgtcaatgta 508501 ctcagagaca tgccgcgcaa aatttattat gtgatcgtca atgaagcggg agcaagcgtc 508561 tattcggctt cagagcttgc cagagaagaa ttccctgacc ttaaggttga agagcgcagt 508621 gccgtatcta ttgctcggag acttcaagac ccgctcgcgg agctcgttaa gatcgatccg 508681 aagtctgttg gtgtcggaca gtatcagcat gacgtcagcc aaaaacgctt aaatgaatct 508741 ctgcggtttg tcgtcgaaac tgtcgtaaac caggttggag taaacgtcaa cacagcctcc 508801 gccgcgctgc ttcaatatgt agctggatta tcgaagtctg tagcaggcaa cgttgtcaaa 508861 aaacgtgagg aaatcggaaa gttttcaaat cgaaaagaac tgaaggacat cccaaggtta 508921 ggtgcgaaaa cctatgagca atgtatcggt ttcttaagag tgcaggaagg gacagagcct 508981 ttggatagaa caggcatcca cccggaaagc tataaagaaa caaaagcact tttgaaaaaa 509041 ctcggacttt caacagaaca tatcggcacg gcggaattga aggacaaaat caatcagctg 509101 gcgctctctg aaacggcaaa agagctggga atcggcgaaa tcactctgaa agacatttgt 509161 gaacagctga caaggccgga acgcgatcca cgcgataagg tgcctaagcc tttgctgaaa 509221 acagacgtcc ttcagctgga agatttgaaa gagggaatgg aactgcaggg caccgtgcgc 509281 aatgtagtgg acttcggagc gtttgttgat atcggagtca aacaagacgg gcttgtgcat 509341 atctcaaaat tgagcaatca attcgtcaag catcctcttg atgtcgtatc tgtcggcgat 509401 attgtgacag tttgggttga cggcgtagat gtacaaaaag gcagagtatc gctgtctatg 509461 gtaaaataaa agcactgctt acgagcagtg ttttttccta tagaaatacc agcattgatt 509521 cagcagttta atttggtaat tatctttttc aaggaacgct ttttgcatct gctttttaag 509581 ccaatttggc ataggctcat tcctcctcag cttttatcat aagagggaca gtgattacca 509641 tattgtatgc gaacggtgaa ttgtcccgtt caatgttttt taagtgaggt gcaccatgga 509701 taacaaagag cttcaaaagc tgacagagga tatttctgaa acatatttta aaaagccgtt 509761 ccgccatcag gcgcttttta atgaccggct taaaaccact ggcggcaggt acctgttaac 509821 ctcccataac attgaattga acagaaaata tttgattgaa cacggcaggg aggaactgat 509881 tggcatcatc aagcacgagc tctgccatta tcatcttcat cttgaaggaa aagggtacaa 509941 gcacagagac agagatttta gaatgctatt gcagcaggtc aacgcgccga ggttctgtac 510001 accccttaag aaaaaagcgg aaaacaaaaa aacttatatg tatatctgta cgacctgcgg 510061 ccaacagtat ataaagaagc gcgccatgaa ccctgacaga tacagatgcg gaaaatgccg 510121 cggaaaaata aaaagaattt tttcgtgaaa aaggttgacg aatatggcaa gcctatgtta 510181 cattataaaa gtcgtcacga gagataaata aaaacattta cctcttgaca ctgcaaatca 510241 aggctgatat aataagtctt gtctcattat tccacagtag ctcagtggta gagctatcgg 510301 ctgttaaccg atcggtcgca ggttcgaatc ctgcctgtgg agccatattg gagaagtact 510361 caagtggctg aagaggcgcc cctgctaagg gtgtaggtcg cgtaagcggc gcgagggttc 510421 aaatccctcc ttctccgcca taagatttcg atataagttc tcaaccatcg gcccgttggt 510481 caagcggtta agacaccgcc ctttcacggc ggtaacacgg gttcgaatcc cgtacgggtc 510541 attccatttc gttgggctat agccaagcgg taaggcaacg gactttgact ccgtcatgcg 510601 ttggttcgaa tccagctagc ccagccattt ttatttttga aatctaatag taagagccat 510661 tagctcagtt ggtagagcat ctgactttta atcagagggt cgaaggttcg agtccttcat 510721 ggctcaccat ttgtcttttt gcgggtgtgg cggaattggc agacgcgcta gacttaggat 510781 ctagtgtctt acgacgtggg ggttcgagtc ccttcacccg cactttattt acaaagtgca 510841 cgcaaatctg ttttactagg ttaagagcct actaaaccag cacaacacaa tttaatgatc 510901 acgcggtcgt ggcggaatgg cagacgcgct aggttgaggg cctagtgggt gaataacccg 510961 tggaggttca agtcctctcg gccgcatctc aataatacca agggtttaac cacctttggt 511021 attatttttt tgtgtggaaa atacggctat gggagaagac ttgctcacca aaactcacca 511081 gttacttaaa gtaagtcatc caaacggtcg gcggttcctt ctgtttatta ggaaaaagat 511141 atccgttcat tgtaaaagaa acgaaccatg tcctattcgt tcaaaaaaac taaagggtga 511201 tacatattat acatgattaa tatgtatcac ccttttcttt cttgttcaac aatcgcgctt 511261 gaggagaaca taagctaata caactgactc gatttctaaa gttgctccat tcttttttta 511321 aacaactcat ccacaacctg ttttaaaatc tcgtacgact gaatttcctt gctcaattcg 511381 taaatattag ataacacaat taattcatct gcgtgataca tttgttggaa atcaattagt 511441 tcgcgacgaa ttgtttctcg atcacccatg attgtatacc ccagtcgact gtggagaatt 511501 tctaattcaa actgtgataa cgattctagg aagttttcag tgggtggaat aagcttactt 511561 aaattatttg tataaatatc aatatacacc tgcaaatgac ttgcagaaat aaaagatgcc 511621 tcgtctatag attctgctgc aatcacatta atgcaagcga tcacataagg ttcttgtaaa 511681 taagaagacg gttggaaatt ttctcgataa atagagagcg cttcttccat cgaatggggt 511741 gaaaattgag cgccaaatgc atagggtaaa ccaagctttg cagcaatttc cgctgaatcc 511801 gttgaggatc ctaacacaaa aacaggcaca tgcgttccaa tacccggata agcgcgaacc 511861 tcaccctgta cactcttatc cccgacaaaa cgcaaaatat catttacttc tctttcaaag 511921 aaaaacactc cattatggtt ggaacgacga atcacatcgg ccgttttttg atccgttccg 511981 ggtgcgcgtc ctaatgccaa atctacacga tttggatata atgtttcaag tgttccaaat 512041 tgctccgcta cgattaatgg ggaatgattt ggcaacataa taccccctga acctacgcga 512101 atgtcttttg tatttgctaa tatatgttgt acaattgata cggttgctgc acttgcataa 512161 gcgtcgtgat tatgatgctc tgcaaaccaa atccgtttat agcccatatt atctacagct 512221 ttagctaatg acactgcaga atcaatccct tgtttcattg tttctccttg tcttaatgga 512281 gcaactgata aaacagatat atcaaatttt ttcataattt cacctctaaa ataatgaact 512341 tatacaagat caatggaaaa aacattttga aaaattgttt catattaaat ggtgtccatt 512401 cctctttgat ttgcatgcaa ataaatatat actttctcaa acgatcaata cataggcaaa 512461 ataaagttat ttcacaattt cactttactt ttaaagtttt aagcaaacat aaaaaaatgt 512521 tcagtgaaca aaatatgtaa aatacatctt atttttcaga aaggatacaa gaaaatgatt 512581 gatgaaatag ataaaaaaat acttgatgag ctgtctaaaa atagtcgcct tacaatgaaa 512641 aaattagggg aaaaagtaca tctcactgca ccagcaaccg catcaagagt agtaaagtta 512701 atagacaatg gcataataaa aggatgtagt atcgaagtga atcaagtgaa attaggcttc 512761 tctatacatg cttttcttaa tatttatatc gaaaaaatcc atcatcaacc ctatttagct 512821 tttatagaaa cacaagataa ctatgtaata aacaattata aagttagtgg agacggttgc 512881 tatttgcttg aatgtaaatt tccttcaaac gaggtattag atcaattttt aaatgactta 512941 aataaacatg caaactataa agtgtcgatt gttattggta aatagttaac tttataaaac 513001 ggagatgtgc ggtcatataa catgatatat atgctctaaa aaagccctag gttggatatg 513061 gaatttacca agctggggcc tttttataca ttataataac aagcgcatta ttcatcagac 513121 attaatgaag tattataatg cttttttact tccttaatag acaaataaag ctgatagttt 513181 ccatacttca ataaatcatt cagaaggtga tttaaaactt cttgtgaatg aaccgttacc 513241 ttcagaagat aacatgcatc tcccgaaaca cgatgagctt cgctaatttc attacgagta 513301 gcaataaatt tcaataaatc atcatgcata tatgcattca tgaaaaagaa gacaaaggct 513361 gtaaaagaaa accccatctt caattcatca accacaatcg aatatgcttt aatgataccg 513421 ttatcctcca tttttttgat gcgattgcct accgcttgtc ctgtcatatg aattttttca 513481 ccgatttctt tccattgtat ccgagcattt ttatttaata attggagaat ttgaaaatca 513541 attgaatcaa tttgcatagt aactcctttc acagtgaaaa agttttacaa aatagtattt 513601 catgagacca tcgaaaattc aatggaaatt atatatcctt atacagtata aaaattttaa 513661 gaggtgaaaa aatgacaaca gctttattag tgattgatat tcaaaatgat tactttccaa 513721 atgggaagat ggctttaaca aacccagaga aagcagcaca aaatgcggct aaactacttt 513781 cacactttag aaacacaggc gcacctgtct ttcatgtaca gcatatcaca gaaggtaaca 513841 tcgctcattt tttccatcca aatacagaag gtgtcgaaat tcatgagtca gtacgtccat 513901 tagagaaaga gacagtcatt gtaaaacata tgccgaatag ctttttcaat acagatttaa 513961 atggaaagct acaagaagaa ggggttaaag aattagttgt ttgcggtatg atgtcccata 514021 tgtgtattga tgcaacagtt cgttctgcag ttgaacatgg ttatgtatgc caagtggtag 514081 aagatgcttg cgcaacaaca acattgcaaa ttgaagataa aatcgttcct gctgagcatg 514141 tccattacgc atttatggcc gcattaaatg gtgtctatgc aacagtaaaa accacagagg 514201 catttttaaa ataaaagaat ttcctgcgcg aacataacgt ctttcttttc acaagaaaga 514261 tgattcaaca acttaaaaaa ggatgttcag aaaaatactt ctggacatcc tttattcatt 514321 atcttttatt gtttttcagt atcattattc ccatctgata aaagatcaag atgtcctgtt 514381 tttgatccat agtaagacca tatacaggga ttgtttttgc cataaatata gatattgatg 514441 aaggtttaca taaagcacct aattgcttga tttactttaa tgttagatcc ctcaataact 514501 ccattctctt ctaatttctc tactctagct gtagctgctg ggcatgttaa atgtactctc 514561 tcccagatct ttcattgaat tcggctatta tacataattt ctctataatt ttttatctgt 514621 ttgatctatt tgaacgttaa ttcctttcga aaataaagtc aaagagttaa aacacttttt 514681 tttatctatg tattcgaaca ctgctgatat tatacactta actctgtcga tctaagacaa 514741 ataaaaaaag aaagtgagtt gtaaatatga atattacaca aattcgaaat gcaacaattg 514801 ttgtaaaata cgcaaataaa aaatttttga tagatcctat gttagcagag aaaggtacgt 514861 acgctacttt ccctgaaacg atcagacaag atttatttaa tcctttggtg agtttgccaa 514921 catcaattga taacattctg gatggcgtag atgcggtaat tgttactcat ctacacctag 514981 atcactttga tgatgtggca aaaaacgtat tgccaaaaaa catcaaaatg tttgttcaaa 515041 atgaagcaga tgcaaaagaa gtaaaagcaa gtggtttcaa aaatgtagaa gtgctacatc 515101 aagacactgt ttttgaaggg atccaattag taaaaacaaa aggtgaacat ggcagagggg 515161 aagagttatt aaacttaatg ggtgatgttt gtggattagt attcaagcac ccaagtgaaa 515221 aagttttata tgtagctggg gatacagttt ggtatgatgc tatcgaagac gagattcata 515281 cacatcaacc agaaatcatt gtggttaatg gtggagacaa tcaaagatta gatttaggtt 515341 cactcatcat gggaaaagaa gacatctatg aagttcacaa ggctgctcct catgctaaga 515401 ttatatctgt tcatatggaa gctgttaacc attggacact atctagagaa gaattaaaaa 515461 actttagtaa agaaaaagga ttctcaagta atattttagt gccagaagat ggcgagtctt 515521 acacatttta atatgaacac cgacaaataa atagaagaag ctcataatta taaaaactaa 515581 tcatgagctt cttctaataa tgaatatttt aaattttaaa tatatcgaaa atcctaaata 515641 tacggaataa caaaaatgga atgttccaat gatgacaaaa aaacttgaaa agcaacaaag 515701 atgtgtcgtt aggaggtaga attcatggta atgacaaaaa aagatacaaa tatatcaaca 515761 cagcagcctc tttggttaca aggttatatt gattcaccag aaaaacaaaa ccaactttat 515821 aaaaaaacat taaaaatctt gattttttca caaatatttg ggggagcagg acttggagct 515881 gggataacag ttggggcgct tcttgcacaa gatatgatag gatcggaaaa tgtagcagga 515941 attccaactg ccctctttac ttttggatct gccgtagctg ccctgcttat aggagcatcc 516001 tcacaacgtt ttggtcgcag agctggactt gcaggtggtt tccttatagg cggattaggt 516061 gctataggtg tgataatcgc ggctttaatt aacagcgttg ccctattatt tgtttctctt 516121 cttatttatg gagcaggtat ggcttctaat cttcaagttc ggtatgctgg gacagacctt 516181 gcaaatgaga aacaacgggc aactgctgca agtatggcct tagtttctac tactttagga 516241 gctgtagtag gtcctaactt agttaataca atgggggaat ttgcagattc aattggtgtt 516301 cccaatttag ctggtccgtt tattatgtca ggagcagctt ttataattgc tggaattatt 516361 ctcttaattt ttcttcgtcc agatccgctg tttgtatcaa cagctattgc gaatgctgag 516421 aaaaaagacg ataaagtaca aataggagga agtctaaaaa atcctgctat agacaaaaaa 516481 ggaataatgg taggagctgt cattatgatt ttagctcaac taatcatgac agctattatg 516541 acaatgacac cggttcacat gggtcatcac ggtcatggtt taagcgaagt gggattagtt 516601 ataggactcc atattgcagc gatgtatctt ccttcaccat tgactggttt attagtagat 516661 aagtttggtc gcacaactat ggctattgct tcaggtgcca cacttcttgc cgctgggttg 516721 gtggcagcta ttgcaccggc agactcatta tcattgctaa tcctagcact agtattacta 516781 ggggtaggtt ggaactttgg tttactaacg ggaactgccc ttattataga ttcaacacat 516841 ccatctctac gtgcaaaaac acagggaaca ttcgatgttt tattagcact atcaggagca 516901 gcaggtggag ccttgtcagg aatggttgtt gcacattcta gttatacaat actatcaatt 516961 tctggagccg ttttatcatt gttactcatt ccagtagtta tttggtattt tagaaggatt 517021 caggaaaaag cataagctta tataactgtc tttgaagaac ctaagtagac attactttac 517081 cggaacctcc tttttctatt tattatagta aggagttgac atggcattag tggcatgtgt 517141 ataactacac aattatttgg gattcagaga gcatgtaatg aacggaagag ataattattt 517201 atcactttta ttattgtacg gtgttcttgt ggcattaagt tcagtcaatt ttggtctaac 517261 tgttttcttt ttgttttcat cacctctcca tattattaac aaacacgaaa aggattttaa 517321 tgaaaataaa atgattagcg tatgtatctc taattttcaa aatgaatgaa tagtcctttt 517381 taagatttac acacttattc tccaaggaaa aatgactcaa tttttcgatt ttttatgtaa 517441 atcaaaaaag aatcatgtta gagtaggtgt gctgaaaata attcaaaaaa ttattttgcg 517501 atatgattaa agtaatattg ccagagagtt tcaattggac aaaattgtaa gtgtttaata 517561 cactggggct gcaatcaaat atgcacctgg aatcaattgc taaacggggg agtttatatg 517621 aacaacaaga aaaatatctt tgatattgtt atgtacatta ttttcggtgt gttaagtctt 517681 tttctagttg caaaaactga ttatggcact ggagttttag tgtttgttgc aattttatac 517741 ctcgctgtta ttgcttataa aattaagcaa gtatttagta attcagattc ttaaggtgta 517801 acacaaggag gatttcaatt gagaaagaaa agagttatta cttgtgttat ggctgcatca 517861 ttgactttag gctcactttt acctgcaggt tacgcttctg caaaggagga ctctaagaca 517921 accccttctt acgaagaact agctctacat tacaaaatga aaagtgaaaa gatttcatcg 517981 aacgggaaat tagttgaaat tgagtatgtg agtggaaatg aaactcacaa agttcagatg 518041 aacggaaata atcatactgt aaaagtcgat ggcatagaac aaaaaggttt aaactttgag 518101 tatgatgaaa atgttgctaa aagaacaaat tatgaaaaca ataatttgaa atcaaatgaa 518161 ttcacaacac aggctgcaaa acctaaaaag ggataccatt atgtggggac tttatctggg 518221 catacaaaag cagctaaaaa tgcgttatca gttacaatgt cattagtcgg tattgtccct 518281 ggcttgggat gggggagtaa ggctgccact attttattct cttattgggc aaaagaacaa 518341 atccctgatg cgtattataa atatgattta tacgaaaaag gagcaatgac tgatagttgg 518401 tatcagtatg ctacagttca attttttgaa gataaagctc ataaaaagaa aatgggcaaa 518461 ccttggacaa gtactcctgc aaaagtagat ttacctaata gctaatttta aaatcacttt 518521 gtctttataa aggacaaagt gattttttgt tatacagaag taaaatccct cgtctgagga 518581 atcttggaaa aaacttggtt caattttgat ataacatgtt tttttcttgc taatttagtt 518641 tttctatgta tcgctacaca ttctaaataa taagatatta gccggacggt tgatgccaag 518701 ctcaaaagtt tatatggaag tcaaagcata aaaaagggtg ttacaacgtg tagtcttctt 518761 tttattttgc caacgtaaca agtgtgaaag taatgatttg taggatcagt taagaaaggt 518821 ttaagattag atattgaaaa attttatata ttttcaataa aatactggta ctataataaa 518881 tgtatacaga ttgtatggag atgtaattaa ttaaaaagga gttttttaat tgcgttggag 518941 taaatggttc aatgtttttt gtatagtagc attgggatca atatatggtt ataaattatt 519001 tactaaccaa gaagtcagta ctactcgttt aataatagct tctgtaattg tgttgtggaa 519061 tattgttgga ctttttagca aagaatcagt aaaacaagca cagcaagcaa attaaaagtc 519121 ataaagttgg gaaagaagga tgttacttat gtagtatcct tctttattat tccttgaaaa 519181 atgaaacaaa ttggagatta cagcttatat aatcaattga agtcgttgat tattttcatg 519241 aacaggagat ttaatgcttt ctgatgaaat attatcgtat gaatgttgca agaggaaacg 519301 ttactcaaag attacaggga tgtgatgaac actcctcttt atcgcactca cctgacccca 519361 aattgttggg gaagggcagg tacggaagat agagtatttt ttcttcgtaa caaatcgaaa 519421 aggttggata ataaaaaact tataatctaa ggcggtatat agttgtgaaa aaggcgttat 519481 ttcttatatt agaccagtat gcagattggg aaggtgttta cttagcatct gcattaaatc 519541 aaagagaaga ttggtcggtt cacactgttt ctttagaccc tattgtaagc tcaataggtg 519601 gttttaaaac atctgtcgat tacataatag ggttagaacc tgcaaatttt aatttgctag 519661 ttatgattgg cggggattcc tggagtaatg acaataaaaa actattacat tttgtaaaaa 519721 ctgcatttca aaaaaacatt ccaatagcag cgatatgcgg tgcagtggat tttttggcga 519781 agaatggttt gctgaataat catagccata caggtaattt tgtttactta tggaaagatt 519841 acaaacaata taaaccgatt agcagttttg tagagaaaca agcagtaaga gataaaaatt 519901 tggttactgc taatggaact gcccctattg aatttactaa tttaatttta gagatgattg 519961 attttgatac tcctgagaac atagagaaaa tgatgtatat gaatcgttat ggtttttatc 520021 atttttgtga taaatatgga aatccatttg ttgattaatt tgctggaaat gattttcccg 520081 aatagggggc tttgcgattg agttgaattt cctaataaag caaagaaaga tgatttgagg 520141 tcaagtttaa caaataatgc catcaatatt aatttgcagt tatttccgat tcctgatata 520201 ataaagaaga attatttttg ttcggtgtaa aggatagtat gaagattgac ttttcgtctt 520261 gatgatactt tgggcaagga tagtatatac tgtgtggtta cacactagga ggcaacaaaa 520321 atggaacaag gtacagttaa atggtttaat gcagaaaaag gttttggctt tatcgaacgc 520381 gaaaatggag acgatgtatt cgtacacttt tctgcaatcc aaagtgacgg attcaaatct 520441 ttagacgaag gtcaaaaagt atcgtttgac gttgagcaag gtgctcgtgg agctcaagct 520501 gctaacgttc aaaaagctta atcttcaatc gtttatacaa acaggctctt tatatagggc 520561 ctgttttttt atgtctatat catactcaat aaaaaaccct actcaacgtt cgagtaggga 520621 gatgctacaa ggtaatagaa aaagatttaa aacttcaaag gtttgtttac agtataacat 520681 actggattga caatatgcgg aatgtatata aattatttaa tgttttgttc aaatatagat 520741 aactgactct ttttttcact aacctgttcg ttcatttaag taagattaga tgaattataa 520801 aaatggtttc atctaaatgt tatcaactcg catatctctt ttatgagaag aagataaaca 520861 attattattc aatgttgcag tggatataag aaattcttaa aaataatgag gagatcgatt 520921 gtttttttct cctggaaata atcacttaga gatacctaaa acaatgaaag ccctacctct 520981 cttccatcct tacggctcct tgtccgtgcc agtgtgaatc aggatactaa aaaaagtgac 521041 tattttattg agttttttgg taaaacttca atcttcgcag aagaaatgta aataataaaa 521101 atggattaga atgtaggaat aacaaaagag gtcgttaatg ttctaaacat aagttggaga 521161 agatttgctt ttcatcataa tattccgaaa tatcttttgg gatgtatcta accaaaactt 521221 tttatttgtt tttcagtgat tcctttaatt acttccagtt cactaatcaa aaattcatat 521281 gcattatcca gcattttttt ttcgcttgca ttaagtgctt tttctttctt catacgcatt 521341 aaatcacgta caacttcagc accttcttgt atttcacctg tttttatttt gtccgtgttt 521401 attttgtacc tttgcttcca tggcagtaac ctatcggatt ctccatgctg aaaaatgtgc 521461 ataatgtgtt ttaatgcaag tatatcggta actggtcgta tattcgaact caatatttta 521521 ctcgttggaa tcataactgt catattactg attgacattc ttatgacata atactgttgt 521581 ttttcctcta agaattcttt ttcttctatg gcttcaatta tacctgctcc gtgcattgga 521641 taaacaatgt tatcgccaat ttgaaacata tcatccacct ccatatatgg tatccttctt 521701 aagattacca tatatggagg tgtaatatca aaattttaat aataacatga tcgaattttt 521761 gatgtcaata acttttttga aaaaacagat caagcaaaaa caatagggaa cgtgtcggat 521821 ttccaatcag gaaaaggtca attgatccgt gtgagcagtt tttcattggc tcaatgacat 521881 tacagaaatg atttgagtag ataagaaaga acgatattcg tgaaatgtca gctaaaaata 521941 tttaaagcac atgattaagt tctaatttct ttaccgattt gatatggata acggccgact 522001 tacttaatga tgcattttca cttatcttgc aagcagaaaa aggtttgttg ataaacattt 522061 agccaccaaa ttggcattat tatcagggaa attgacaacc ttcaaatggg tattgaggcg 522121 agaagaaaaa taaagaaagg agagattata aatgaagacc agaacataaa gaagtaaagg 522181 ggaaagaaca aggttaattg aaaagcaaac tatataaaat agtttgcttt tttttgttat 522241 gacttcactt ctttttcttt ctctttaatg actaataaaa caccgctcag aattaaaaac 522301 gaacctatcc aaaatgtccc gcctatttgt tctccaagca gaatccatcc gagtaaggtt 522361 ccaaccagag gctgaaaaaa gaaaaagagg cctccacttg aggcatttaa taattgtaag 522421 ccgtggttcc acaataaaaa tgcacaagct gttgaaacaa ttcccaaata caaaaggcca 522481 cctagaattt tagggtcaag cagtagtggc gtaaaaatcg tgctagggga gtaccattaa 522541 cagggactcc atttattaat agaataaact ttatgaattc atttttttgt atgataatgg 522601 cgtcatattc atcgcttgtt gaaatttact tatgaaataa ctggtactgt taaatccaac 522661 ttgataagac acttctgtca cattggattc agggtgttgc agtaataata agcttttttg 522721 aattctataa tccattacat aacgtaatgg cgtcttattc agcattcgtt taaaataacg 522781 gcagcattca gaacggctca gttggccagc ttttgcaatg tcctctaatg tgattttttc 522841 aacataatgg agatggatcc agtttaacat ttgtttcatt cgatgacttt ttatcatttc 522901 agattgatcg tactctaatt gaaaaccatt aacgaccagg tttttccaca ttaacgttaa 522961 ttgcatcgta atgtcaatct catagagcga tgtcttttgt tgaatcaatt gatttatttt 523021 tttaacagca tctagaatat tttttgccca ctgttgattt ccagccaaaa ataaataggg 523081 caaattggtt gaaaacatat agggctgaac atagcttgaa tacagttcct gagataaaac 523141 gaaatggggt gacacattca agcaaatata cgtacaatcc gagccttcct tttcttcggc 523201 catgtgcagg tagccgctat tgataaataa tccatcccct tcgtgaacct ctattttttc 523261 ttcatttatt tgaaagagag ctatcccttt tagtatcaaa acaaattgga tttcatcatg 523321 ccaatgaagc ggaatatagc catttatatt ttgattgatc gttgtcttgt agcaggcaac 523381 tggcaattct accgttcggt gctctgttaa ttcttttaaa ttttgatcga tcacaaaatt 523441 cttcattctg acttcacacc tcaatatatt tatatttttt cattcaattt gagtattttt 523501 tatcatgttt tgcatttatt ataacactat tattatattt attagtgagg agtcatgtat 523561 gaatacttcc aatagaagaa tgggattgtt ctatgttatc acaggggcga catgttgggg 523621 gattggaggc acagtagcca aaaaactttt tcaagaatat caaattgatg tcaattggct 523681 tgtaacgaca cgcttgctta cggctggaat gttactttta atgctgcaac tgttcagaaa 523741 ggatcgttcc caggttattg aggtgtggaa acacaaagcg tcggctggcc agcttctaat 523801 ttttggccta ttgggaatgc tagctgtgca gtacacatat atggcatcca ttcaacatgg 523861 gaatgctgcc gttgctacgt tattgcaata tttatcccca gtaatcgtca ttatctacac 523921 gctgttgcga aaacaaacgg ttcttaccaa acaagatatc ataactgttg tacttgcttt 523981 agtgggttgc ttttttttgt taacaaatgg ttcaatgtct caactttcag tgccggcagc 524041 tgcagtagta tggggagttt tatcaggatt cgcggcagct ttttatactt tgtatgccgt 524101 tggtttatta aataaatttg attctcttgt cgttgtaggt tgggctatga ttattggcgg 524161 ttttgcattg ggttttatcc atccgccatg gcaactggat tttcaacgat taactgctga 524221 ggcgtatgca tatatcttat tcgtgatatt atttggaaca atgattgcgt tctggttctt 524281 cataaaaagc ttggaaagcc tctctccaaa agaaacaagc ctactaggca gtctagagcc 524341 tctatcagct gttgtaacaa ctgtcgtttg gttaaaagcg ccatttggtt cttttcaatg 524401 gattggtgct atttgtatta tagggataac tttaatattg gctttacata aagagccttc 524461 tatggagagt gaaaaatcga tattaaagat taggaatcat gcaaatcggg atatataggg 524521 gctttttttg cttacatgac cggtccggca atgaaaaaca ctggtggagt ttgagccctc 524581 tcggcagtat caaaaatacc aagggttttg acgccctagg tattttttct tcaagaacct 524641 tcaatttttc ttctctgatt gaaaaacgta ttactttttt gtgattggta tccaaatttc 524701 acttttaaaa gatggtgatg ttacatcctt atgctcgttc cacaatattt ctggaccttc 524761 tatttgttcg taatttgacg atggaaacca ttcggaataa atgcgtcccc atacttcttg 524821 cagtgtatcc ggaaatggcc cgattgattc gaatacagcc catgttgagg caggaacttc 524881 aagccgtgag aagttatctg gacaccgttt cgttgtggct gcgccaatat agtgatcgag 524941 ctctccgttt tcctctgtcc gaccttcaga aaaattcgtg gatgcactaa tgaggcctga 525001 tggtgctaca ttagatagct cttttagttt atttattgct ttttcatcta aactttccca 525061 catagatgca atttccggat taattccttt gaaaataata ggaactcttt ttttaatgcc 525121 aacgatgcga aatgcctctt tttcttcaat acggtagttc atttcatttc ctcctttaat 525181 tgttagctgg aaggtcattc gtggataagc tttaagggaa tggccattaa atctggcttt 525241 tgatgggttt atgccatgta aattttggaa tgcccgtgca aaagaatctg gtgagttata 525301 accgtacttt attgcaatat caatcacttt tacattgctg tctttcagtt caaaagctgc 525361 aagagtaaga cgtctgcgac gaatatattc cgataatgaa atacctgcaa ggaaggaaaa 525421 catcctttta aaatgatatt cagagcagaa agcaagcttt gctgcctctt gaaaatcaat 525481 atcattagtg aggttttctt caatatactt taacgcccta ttcatacttt taagcaaatc 525541 catttatttg gcctccttta accaaagaat aacaggagtg aaatgtattt atccgacatt 525601 ctgtgcacag ttttgcagga tgacttatat gaaataaagt aagtgattca cttgtatttg 525661 tacaggtttt attgaagcat gctgttcata aaaaggcatc aataaaagaa agttataatt 525721 gtcttataaa cggcacattc atataattga gtgaaaaagg atgcgtatca tgcctatcaa 525781 ttcttttgaa aattatccga tgagctggaa gccatcgatt gataaagctg aaaagcctat 525841 ttataaagca cttgcagggc aattggaaca ggatatttta aacggagttt tattacctgg 525901 aacaaaactt cctccacagc gagaattggc cgattatcta gatttaaatg tgagtacgat 525961 ttcaaaagca tttaaagtgt gtgagttaaa agggctgctg agtgcgactg tagggagcgg 526021 cacatttgta tcgtatgatg cgttgtcgaa tgcgtattta cttgaggata ctaagccgac 526081 acatttaatt gaaatgggag caatacttcc agatcacgct tcatatgagc ccttgttata 526141 ccaactgaaa aacatggttc atgaggagga ttatgaaaaa tggtttagct atggccgggc 526201 aggtgaaagc ctttggcaaa aagatgcagc tgtaaagctc atccaaagag gcggatttga 526261 aacatccgtt gatcacattt tatttgcaaa tggagggcaa aatgcgattg cagcgacatt 526321 ggcgagtctt tgtaagcctg gagatcgcat cggagttgac catcatacgt accctggatt 526381 aaaaactgtt gcatcattgc ttagtgtgca aatcgtaccg ataaaatcag aaaacgatga 526441 aatgagtccg gagtcacttg aatatgcgtg taaaaacgaa aatattaaag gtttgtattt 526501 aatcccggat tatcataatc cgacgacttc ctttatgtct gttgagaatc gaagaatggt 526561 tgcagacatt gtaaagaaat ataatctgtt tgttattgag gatgcatcgt accatcttct 526621 caacaaaaat ccgcttccgg cactcgcctc attcgcaccg caacaggtta ttcatattgc 526681 aagtttatca aaatcgttag cgccaggcct gcgtttggct tatgtagcag tgccgagaca 526741 atataaggag ccaatatcaa aggcgcttta taatttaaat ataactgttt ccccgctatt 526801 agctgaactt actgctcgca cgattgtatc aaatcaattt gaagtcttaa ttgagagtca 526861 tcgtgaacaa accattcgca gaaatcaact cgtaaaccga tatgttgcgg gatatacatg 526921 tttaggtgtt gaaacaggca tttttcgttg gttgttgtta ccgggtaaaa tgtctggtgc 526981 cgaatttgaa gaattggctg ctcgacttgg cgtgcaagtg tatgcggctg aacgctttgt 527041 agtgggaaat agttgtcctg aaagggctgt aagggtttct gtctgtgcac caaaaacact 527101 tgaagagctt gaacaaggat taatgatcct gagacgtttg ctagacgatc ttacctaata 527161 ttgtttgcca tacaattatg acattgtatg gcttttttgt gcgtgttatg atgatccaca 527221 tctagaggga ggtttataca aaattggctt ttagaaagga aggtcagatg atgttagaca 527281 aggacagcgt aaaagcaata gatgttcaaa ctgcttcatt acagagctac atcagttcac 527341 cagaaaaaca aaaatcgtta tacaagcgta cactattcgt tgtgagtatc tcacaaattt 527401 ttggcggtgc ggggctggcg gcaggagtga ctgtcggtgc gcttattgca cagcaaatgc 527461 ttggcactga tgcgtttgct ggtttgcctt ctgctttatt tactttaggg tcagcaggat 527521 ctgcattaat tgttggaaga ctttctcaac gttatggccg tcgaacaggt ctttcagctg 527581 gctttatgat tggcggactt ggagcaatag gcgttattat ggcagcaatc ataaatagta 527641 ttttcttgtt atttatttcg ttgcttattt acggtgcagg tacagccact aatttacagg 527701 cccgttatgc aggtacagac ttagcaaatc ataagcagcg agcgactgct gttagtataa 527761 ccatggtttt tactacattt ggcgcagtgg caggtccaag cttagtgaat gtgatggggg 527821 atttcgctct ttctattggt gttccatcac ttgctggccc tttcatttta gccgcagcag 527881 catatatgtt agcaggtgtg gtccttttca ttatgcttcg tccagatcca ttagttatag 527941 caagaacaat agaagcggca aatgaagagc ctggtgataa aggacatttg gcggcaactg 528001 agcatacaga aaacaaaaaa gggataatcg ttggggcaac ggttatggtt cttacccaaa 528061 tagtaatggt agctattatg acaatgacac cggttcatat gagacatcat gggcatgact 528121 tgggtgcagt cggtcttgtt attggttttc atataggtgc tatgtatctc ccttcacttg 528181 ttacaggtgt tcttgtagat aggttgggac gtaccgcaat ggctatttcc tctggaacaa 528241 cgttgctttt ggcaggtgta atagcagcat ttgctccggg agaatctatg attcttctcg 528301 tcattgctct ttctttactg ggattagggt ggaattttgg tttgataagc gggactgccc 528361 ttattgtaga ttcaactgat actgccacac gagctaaaac gcaggggaca gtggatgttc 528421 tgattgcgtt gtcaggagct gctggcggag cattatctgg aatgattgtg gcaggttcaa 528481 gttacctcgc attatcactt attggaggga ttttgtcctt attactcatt ccggtggtgg 528541 tatggtctag gggccgctaa agggtaggat tgtttaattt acattaattt gttatattgt 528601 tagataaagt atattgcagc atctaatatt ctaacgaact atagttgctc cattaaatct 528661 attataaaga tttgaccagg attccttata gctgtgtcac tcactgcata ttctttaatt 528721 gaatcacata aaatggttat cggatttgaa aaaggcagga ttactcgctt taggtaaagg 528781 agtcataacg ttgttaaaaa ggttttctct tgttattgtt acactaatga tgtctatcgt 528841 tgttgtttta gcggctgcta aagagtcgcc tggagatcat gtcatctcat ttgatgaacc 528901 tattatcttg atgatctcaa ttggaatcgt tgtattttta ttgatccctc cattagtcat 528961 gtcctttttt ggcaatttgg ttgtaagaat aatatctggt gtataccaat gttttatcgt 529021 tttcactttt ctggggctca ttccaattgg atttcttatt cccaatggct ttttgacaat 529081 tctagtttct attgcaggaa ctttagtcag tatagctagt gttgccgtaa ccttatgcat 529141 tggcaagaat aaaaaagata tataatcatc gaattgttat tttttcagat tgtcagtgaa 529201 ataattatac aaaaagagaa ggcttgtggg ccttcttttt ttgttgttgc atcatcccca 529261 ctttgagctt aatctattga ataataagag aaggaaccta tagaagaata aaataaatac 529321 cgagatgtca aaaataaaac tggacttcat tattgtgaat tcacgtaaat gtaaaaagat 529381 tggaaagagg ggaattcctt catgacaaat agcagaacaa atccgaaggt tgatgaattt 529441 ttaagtaaag cgaaaaagtg gaaggaagaa tttgagaagt tgagaaccat cattcttgac 529501 tgtgagctga ctgaagattt taagtggatg catccttgtt acacatatca taataaaaat 529561 attgttttaa tacatgggtt taaagaatat tgcgcgcttc tgttccacaa aggcgtctta 529621 ttacaggata cagatggaat tctcattcaa caaacggaga atgtacaggc ggcgcgccag 529681 attcggttta caaatgttca ggaaataaat gagctagaaa acattttgaa agcctatatt 529741 cacgaagcca ttgaagttga aaaagccggt ttgaaagtgg atgttaacaa aaatattgaa 529801 ttgaacattc ctgaagaact tcaaaataaa ttcgatgaaa tccctgcatt gaaaattgct 529861 tttgaagctt tgaccccggg acggcaaaga gcgtacactc tttatttttc tcaagccaaa 529921 caatccaaaa cccgagaatc gagagtcgaa aaatatgtgc aaaaaattct cgatggaaag 529981 ggattaaagg attaggcacg ccaaggttca ggctaaagga atagcatcat agcgtaataa 530041 gatcatttct atagaagaaa aacaagcata gtaagatgct tgttttttct taggacaaca 530101 ttcacttact gctgaaatgc ttctaacatt gtatgccact agacagcgtt ataaaatatt 530161 aatgcaacac ctagaaatct atccaatgaa atagctcaat ggtatggctc attacattta 530221 gaatgcctag gagaactaat agaaccggaa gatttttagc aagttactac actccaaact 530281 ttgtttttgt attaatatac cttattaacc attgttttta gtcaggtgca gacaaacgaa 530341 tactgattaa tgaatcatca tgatatcaat gagccgcttg attttttcat cgtcgcctgt 530401 atcaacgtac actgtttttc tgttttttat gatactctca gtcacttccc gcatgacgcc 530461 tttttctata tcatcagcgg aatcccagcg taaaggcaca ttatatacat gaattgtgcc 530521 atccccattg ccatgataag tgactgatcc atccactaaa cgagaacctg ccaactgggt 530581 cacattttct ggatagctgg cacttgtatc atcattagga ttaattggct cgccagccgc 530641 aatatgtcga acatttaatt catctatctc ttgattaggt ccaagttgaa gccaaactct 530701 ggcatattca attttttccg aagagtatgc tgccaataca ttgtcttctt tgcttttctc 530761 ttctgctgaa gaggtatcat ttgcagcttt tgttgcggat tcttctgatt ctgttattgg 530821 ctccgcttca tccttgcgta ttttggtgct ctcttcaggc tcagtgtgtt tttcgtcagt 530881 ttgcacagca gaagcttgat ttgaaggttg ttgtgcttct ccatccttac tgtccgtaca 530941 tccagcaagc aaaatcataa gcagcagggc agtattgcaa taacatatct ttctgcgttt 531001 cttcattttt tcattcctct ctattaattc aggtcagctt catatataag tttatgtatc 531061 taaatattac catggaatag ataggatgat attgaaaact gtttaagaag aggaaacgat 531121 cttgaatagc atcgcgaaaa cctaagaatc ttaagaagtt ttgccccttt ttcttcaggt 531181 attgaatgta aagtgggata taaatgcaaa caaaaacgaa atgccttatc cacctcgtgt 531241 catggcagaa aaagtggggg atttattaga gcggatttga taatggcggc aggtaaatgg 531301 gtgttgactt atatgtctaa gcgggagact caagtctgct cgatcgcata caaaatacca 531361 agggccagca acccttggta tttttatacc ttcatgcatt tttgaagttt atgcttaaag 531421 gtctgcctta ctttgcaaat cgccgagctg ctgcaacgca catgataacg gcgatattca 531481 ctgctacgag tgcccagccc actttctcgt gcagaatcac tgaggcaagc agcagtccaa 531541 aaaaaggctg gagaagctgg agctgcccaa ccgctgcaat tcccccttgg gcaagacctc 531601 gataccagaa cacgaagcca atcagcatgc tgaataagga tacatatgca agactgagca 531661 gtgcgggaac gccgatcgcc gaccatgagt ccggcgtaaa aaagaacgac aatggcagca 531721 taagaggaag cgacagaacg agtgcccatg agatcacctg ccaattcccc agacgccgtg 531781 aaagtttggc cccttctgca taaccaagac cgcatacgac aatagaagcc agcatgtacg 531841 cgtcgccaag cggggatgaa cctcccccct gaatgagggc gaaacctgct actaacaagc 531901 tgccggcagc tgagaaaatc cagaagacgg ggcgagggcg ttcacccccg cgcagtacgc 531961 cgaagactgc cgttgcgagt ggaagaagtc caatgaagac aatggcgtgt gcggatgtga 532021 catgctgaag cgctaaagct gtcagcaacg ggaaaccaat cactacgccg aacgctacca 532081 ctaacaatga aatgagatct cttttggcag gatgctgctg ccggaagatg agaaggagac 532141 ctcccgccag tacaccagct atcgcagcac ggcaaactgt gagaaataac ggatcgaagt 532201 ctgacacagc caaacgggtc gcaggcagcg agccgctgaa aatgagtacg cctataaaac 532261 catttatcca gccatttgtt gttttgttca ttataatcac tccacatatc tttcttgttc 532321 attgtctgta ttttcttaac aaaaccagca gctaaggatt acaatgacta taaactggaa 532381 ttggcctttt ataaacagcc agttttcata aaaaaatgca taccagttag gagaacaacg 532441 cgcaaatgga tatcacgcct tttttgaata gaactctgga tattccgctt tatcagcagc 532501 tttatcggta ttttaaagaa aatatgcatc ggggccgtat tcaaaaagga atgaagcttc 532561 cttcaaaaag actcctggcg aatcagcttt ccatcagcca aacgactgta gaacgtgcct 532621 atgaacagct cgctgctgaa ggttatattg tgagcaagcc aagaagcggg tggtttgctg 532681 attatcatga ttctgatttt gcttatgata gaatgccaag cacaacaccc attcaacaag 532741 aagcagaaga aaataaacaa tggattgatt ttcattatgg gaatgtagat tcttcttact 532801 tccctttttc cgcatggcga aaaagcatgg tcaatagctt agaccaatat ggacacgagc 532861 tttatcggcc gggacatgtt ttaggagagt ttgagctgag aacactcatt gcagagtacc 532921 tgtatcaatc tcggggggtt cattgcggcc ctgaacaagt gattataggt gccgggaacc 532981 ctattctgct gcaaatcttg tgccaagttt ttgagccgaa tatttctata gggtatgagg 533041 atcctggtta tccaagagca cgcaagattt ttgaagccaa ccgcatgaat attgttccta 533101 taccagtcga tgatgaggga atctgtatac agaagatcaa agaacagcag ccaaaccttg 533161 tatatgtcac accttcccat caatttacgc tgggaaccat aatgacaata aacagaagaa 533221 ttcagctgct caaatgggcg gccgaaaatc aatcctttat catagaggat gattatgacg 533281 gggaatttag gtacacagga cagccggttc cttctctgca agggcttgat cagcataacc 533341 gtgtcattta tatgggcact ttttctaagt ctcttttgcc ctcgctgcgt atcagctata 533401 tgattcttcc ttcgcctctt ttaaaaaagg gtcatgaaat cacgtcctta tataagcaga 533461 cagtgtcctg ccacagtcag ctaaccctag ctgaatttat aaaaaatgga gagtggcaaa 533521 aacacatcaa cagaatgaga aaactttacc gcaaaaaaag agccattgta ttagaggcag 533581 tgcaaaggga attaggagag catgtcagaa tccgcggaga aaactctggg cttcgtatct 533641 tacttgacgt ttatttgcca tttggtgaaa aagagttaat tgagaaggcg aaaaaacatg 533701 gagtaaaaat ttatcctgtt tctctttctt atcaacatca tcctcctaca aaaacggtct 533761 cgctcgggtt tgcaggggtt tctgaatccg acataagaga aggcataaaa aaactgaagg 533821 ctgcctggaa gatatgaggg agctttcagt ttagcaaaac ggccaagtga cgactaagtg 533881 ttgagagctg ttcaatattt tttaagtata tgatgagtgc ctgcagtcca ggccacgata 533941 cgtctgttta gcgaaaaaca gaatttttta tttgctcctc acagtgctaa aataaacaaa 534001 atagacaatt gaaaaaatag aggtgtaaga atgaagttag atgagtttac aattggccag 534061 gtcttcaaaa cgaaatcatt aaaagtatca aaagatgata ttatgcggtt tgcgggtgaa 534121 tttgaccctc agtatatgca tgtagatgaa gaaaaagcga gtaaaggcag atttaatgga 534181 attatcgctt ccggcataca aacactggcc atatctttta aactttggat tgaagaaggt 534241 ttctatggag acgatattat agccggaaca gagatgaatc atatgacatt cataaaaccc 534301 gtatatccgg atgatgaatt gtttacaatt gttgaggttc ttgataagca gccaaagaga 534361 aatgaattgg gaatactcac agtattgcta tctacttata atcaaaaaga agtaaaagtg 534421 tttgaaggtg agttatctgt attgatcaaa cgataactca gaaagcccgc ttttcgcggg 534481 ctcgattgaa gcagatgggt gaaagatgtt agcgggtttc ctttgaaaaa taagaggtta 534541 aaacatcata aacaataggc aaagaagtaa atccctcatc ttctagaaaa tgacctccgt 534601 gctgaacttc atataacgca gcatcaattt gttgtgccag atccttgctg aatgaaaaag 534661 gcacaatttg gtcgtcctta gaagcaatga cagcacggtg cttcgcggac tcgatgattt 534721 tttgatgatc aaacgatccc tgtgtaaatt catctaacat ctgtaaagtg ggcaatgatt 534781 tggcaaagcc ggaaacaagt atgattccgc caagctgttt tcgtaattga agatgttcca 534841 aaaatctcaa aatggcgggg caacctaagc tgtgcgcaac caaatacgta ttttcatgta 534901 aagtgtgctg atataaagag agtgtatcca gccaatcctc aagtcttggc tggagcggat 534961 taggcatgtt taaaatgtct gcttggaccc catctgcgag cagacgtttt ttcagccaag 535021 ggaaccaatg atttgttgag gaggctctgt agccatgaat gatatagact tgttttgtca 535081 ttatttcctc ctaagaaata ttttcattca gtataaaatt cctctcattg ggaaacaagt 535141 acgcactttt ttgtaagtag ctttacatat gaggccctcc ttgtgccatt ccccacttac 535201 acatctcatc tatgagggga tacaaagatc gccctctgtc agataacgaa tactctactt 535261 tcagtggggt gtgagaaacc tcagaccgat gaataaggcc gtcagtttgc aattccttaa 535321 gctgtgcgct taacatttta tgggtgatga agggcatagc ccttttcagc tcgccgtatc 535381 tcatcgtttt ttcacaccct aactcataga gaattctcat tttccatttg ccccctataa 535441 gagataaggt gtattcaaat ggggcttgtt tactgcggca caggctattc attgtaatca 535501 aacctccttt tttaagtatc atatcagaat aaattaggat tttcggtgtt gaagtttgag 535561 ggcgattcac gatctgaagt gaaaggggcc gcttgctcaa caggcggcac ggtacatgaa 535621 tgttctaagt caaagagggt taccttactg ttagttactt tatttaaaaa aacgcatgtt 535681 tttagctgaa aatatctatt atggtatatt taaatataaa gaaatatttg agaaatgagg 535741 aatggtatga atacacccaa aaaacataag aaatttaaag cgaaaatgat tctccaaatc 535801 atcatggtta tcattggagg aatcatagcg gcatatggac tagaaacagt gctcattcca 535861 aacagtgtat ctgatggagg ggtgacgggt cttagcatcg ttggttcaca gctattcaac 535921 ttgccgctgg ggattttgat tgctgtgatc aacattccat ttgtctggtt aggatataag 535981 caaattggga aaagctttgc attattatca attatcggaa tcgtatcgct tgccgcgggg 536041 acaagctttt tccaccacac acccgctatc atagaaggag ataccctgtt aattaccgtt 536101 gtcggcggga ttatccttgg attcggaatg gggctggcgc tgcgtaatgg cggcgcatta 536161 gatggaattg acatgcttgc tgtgctgcta tcccgaaaac tgccattcgg aacgagcgat 536221 ctcattctat tcttaaacct atttgtgttt atttttgttt ccacagtatt tggcttacaa 536281 ggggcattgc tttcagtcat tgcttactac attgcatcca aagtgattca tgttgtggag 536341 gaaggcttaa gcggctctaa aacctttcaa attattacaa cccaacctga attaatggta 536401 gagacaatac gtgatcaatt aggccgaagc gccacatata aagaagctta cgggggtttt 536461 tcccacgaga aatttaaaga aatcacatgt gtcatcaacc gtttagaaga aaccaaacta 536521 aaggaaatta ttaatgatat tgataaaact gcctttgtta ccgtgtatga tgtagctgaa 536581 gtgaagggca gcaattttag aaatcttaat catcactaaa aaatagaatg acctttttaa 536641 ccgtaactga catgccgcgg gtaatttaat caaaaacact tttttgaggc ttgtgggtga 536701 ataaccggtg aaggtctgaa tcacagaaat accaagggcg tcaaaaccct tggtattttt 536761 tctggttatt agattttatc ttcagcttta cgtgctgctt cgagcttatc aatcctgtct 536821 ttatattttt ctccccagtc cttcatgtgc aggataacag gttctaatgt tcttccaaac 536881 tcagttaaag agtattcgac ttttggaggg acctgtttat aaacctcgcg gtgaatcacg 536941 ccatcccgtt ccaattctct taattgtagc gtgagcatac gctgggtaat ttttgggtat 537001 agttttcgaa actcattaaa cctcttttta ccgtcaatga gatgataaag aagaatgcct 537061 ttccacttac ctccgatgat atctaatgtt gtctccaccg gacatccttc aaagtcatca 537121 gaagaataat caatgccgag tttacgattt ctcaagctgt tcactcctaa tagtatactt 537181 tttgatacta tatacattca atgtgcgtac tttttatatt ttaatataca tcatataatg 537241 atgtcacatc taaggaatga aaggaatgga tcatatgaaa acactcgtac tcgttgtaca 537301 tccgaatata gaatcctctc gtatcaataa aaagtggaaa gaagccgttt taagtgaacc 537361 agatgtaact gtccatgatc tttatgaaaa atatcgcgat caaccaattg atgtggaatt 537421 tgaacaacag cagctcctgg cccatgaccg tatcgttttt cagtttccat tatactggta 537481 cagcagccca ccgcttttaa aacagtggtt tgatgaagtg tttacgtttg gctgggctca 537541 tggtcccggc ggaaataaat tgaaggggaa agagtgggta actgccatgt ccatcggttc 537601 acctgaacac tcttatcaag ccggcggata taacttgttt tcgataagcg agctgacaaa 537661 accgttccaa gcatctgccc atttagtagg catgacctat ctgccttcct ttgccgaata 537721 tcgcgccaat acaatcagtg accaagaaat tgccgaaagt gcgaatcggt atgtaaagca 537781 tattacaaat atagaattaa acccgaaggt tcgcctgcaa aggtatttga aacagctgga 537841 gagtgtcgat ttaacataaa gattgatttt tgaaaatcct gtactcacca agcaggattt 537901 tttcttgttc agcagaggga ttttaacata tagcaaaaaa agaagaagcc accaaaaata 537961 agctatttgc ttggtcctga ctgcttattt ttggtgaaat acttatttct ctgtgatgaa 538021 ataaagcaaa gcgatgaccg gaaaagcgat tccaatccat aatgctgtac tccatccgcc 538081 tgaggcatat gcccatcctc caattgatga ccctatcgca ccgcctagaa agaagatcgc 538141 catgaataat ccgtttaatc gactgcgaat ttcaggcgcc aacgaaaaaa tagcacgttg 538201 actgagcaca aggtttgcag atacacccat atctaacaga atagcagcgg ccactagaac 538261 tgttataccg acgggggagc tgctctgaat catgagcggc agtaataaag agacaacgac 538321 aacaccgaga gcgattccag tggcaagcct ggttaagcct cgatcagcca ggcggccgcc 538381 tattggtgca gtgactgcac ccgcaatgcc caccaatgcg tagagtgcta ttgccttctg 538441 agaaaaatga aaatcaggac cggacaataa taaaggaaca gttgtccaga acaagctgaa 538501 agctccaaat acaaacgcat gatagatggc acggcggcgt aagactggag tcgtgcgcag 538561 cagcttccac attgaaccga gtaaggcagt atagtttgta tttgctgttg gttttctggc 538621 aggaagcact tttgataata cgatggccag gataacactt accacggcgg acaaagcgaa 538681 tattgcattc cacccccaga tatcagcgac tagactagat atcggacggg aaagcataat 538741 accgagtaat aagccgctca tgacattgcc aacaacccgg ccgcgtgcag cgtctgatgc 538801 aaggtatgat gcaaatggaa caagcacttg ggctgcgatt gatcccaatc cgacgaaaaa 538861 cgcagctgct aaaaacagtg ttccatgctt cacaaatgct gttagtgtca aagccgctgc 538921 gcttagaagg agcgatacaa caataagttt tttgttttcg ataatatctc ctaaagggac 538981 aaggaatagt aagccggcaa cgtatccgat ttgggtgagt gtgacaatca atccagcacc 539041 gcttggagaa agtccaattg ccttactaat taatccgacc aagggttgtg catagtaaag 539101 attagcaaca atgataccgc atgcagttgc gagaagaagg gttaaactgg gtgaaatcct 539161 ctgacctgct tgtttgtttc cattagccat atgaatgaac tcctttttaa gtggtttttt 539221 gagtgtaatc atgacttctc acaagtgatt ttataaactg aacgttcagt ttcgtcgatt 539281 aataaaaata atatactaaa cgttcagttt tgtaaatgga tttctgtttt ctttttttat 539341 tcaatttaag tatactgaac gtatagttta tattgcggga aggaatgatt tatgtgcaga 539401 gtaaacgagg gcggccgcgt gatgaaggaa cgcataaggc gattctctct gcagcctatg 539461 acctattgct ggaaaaaggc ttcgatgcgg tgacagtcga taaaattgcc gagcgtgcga 539521 aagtgagtaa agcaacgatt tataaatggt ggtctaacaa ggctgccgtt atcatggaca 539581 gctttctttc gaccgcgacg gacaggctgc ctgtgcctga tacagggtcg tcagtacaag 539641 atatagtaac ccacgccacg aatttagcta ggtttttgac aagccgggaa ggaaccgtta 539701 ttaaggaatt aataggtgca gggcagttgg atgaaaaatt ggcagaagaa tatcgcacgc 539761 gatttttcca gcctcgccgc ctccaagcga aaggccttct agaaaaggga attcagaaag 539821 gtgaattgag agagaatctt gatattgaag taagcataga tctcatttac ggaccaattt 539881 tctatcgtct gcttataaca ggggatgagg tgaatgattc ctatgtgcgt gatttggtga 539941 tgaatgcgtt taagggagtt caagctacct ctgctacaga gagtatgtag ctgataagaa 540001 ctgcaaaagc tgcggattat atgacaaatt ggttccatcg tacagtgaaa tataagattt 540061 ttgttgctga gcggaatcat cgagggaaaa gttctcttat cggatgtcga aaaagaagtc 540121 attcaatcgt gaatacataa catcatatta ttacattcct tttcatcgat tggaacaagg 540181 gttctatact tcaatggaat accgcaaagt tggagtattt aaacaacagg ggaaaatcga 540241 tggccattat gtaggtgtca tggcaatgga aaaaatactt gcaatgtaaa caggcctcta 540301 aagagacctg ttttttaata tccagatgat tgtctagttt cagcttgggc tctatgacca 540361 ctcccataac tgaaatagtc taatatttat accagaaggg attgtttata taaataaaag 540421 tttatataat gacgggggcg ctaaggaaac gcggggagcg actcaggttt tcgtttcaaa 540481 gttttgatcc ttaagatata cggagcgcta catatggaaa cgtaaagggg aatgtataat 540541 catttggcgt gtatataacg atttgcttat atattgattt gggaaggagg agctcatatg 540601 acgattgatg ttgcggcgat gactcgttgt ttgaaaacac ttagtgatca aactaggctt 540661 atcatgatga gattatttct tgaacaagaa tattgtgtct gtcaattggt tgatatgttc 540721 gaaatgagcc agcccgccat aagccagcat ttgcggaaat taaaaaacgc aggttttgtg 540781 aatgaggaca gaagaggcca atggcgttat tattcaataa atggttcctg tcctgagttt 540841 gatacattgc aattgatctt acatcaaatt gatcaagagg atgaattgtt aaaccatatc 540901 aaacaaaaga aaactcaagc gtgttgccag taaggaggca ttagattgac atcaatgatt 540961 ttggcagtat tcatcttttt attaactcta gtattggtca tatggcagcc gaaaaattta 541021 tctatagggt ggtcagcctg tggaggcgca gttttagctc taatagcagg tgttgtcaat 541081 tttcatgatg tgttaactgt gacagggatt gtttggaatg cgaccttggc ttttgtggcc 541141 atcatactga tatcgttaat tcttgataat atcggtttct ttgaatgggc agcgcttcat 541201 atggctaagg ctgcaaaagg atacggtgtg cggatgttcg tttatgtatc tctattagga 541261 gctatcgtcg ccgcgttatt tgcaaatgac ggtgcagctc ttatattgac accaatcgta 541321 ttagcgatgg tcagagcatt acattttaat gaaaaattag tttttccttt tatcattgcc 541381 agcggattta ttgcggatac cacttcgctt ccttttgtag taagcaattt ggtcaacatt 541441 gtttcagcgg actattttca tattacgttt attgattatg catccagaat ggttgtcccg 541501 tacctgtttt cgctgctggc gagcatcatt gtactttacc ttttctttag aaaaagcata 541561 ccaaaacgct atgatctgac tgaggttaaa aaacctgttg aagcaattaa agatcaaaac 541621 atgttcagac tgtcatggta tatcttaggg ctgctgttaa ttggatattt tgcaagtgaa 541681 tttttttcta tccctgtatc agtggtagcg ggcagcattg caatcatttt cttaatcgct 541741 gcgcaaaaga gtccggccgt ccatacaaag aaagtggtga aagaggcgcc atgggctatc 541801 gtattctttt caattggcat gtacgttgtt gtgtatggtg tccgaaatgc cggattaacg 541861 gatgtccttt cagatgtgat tcaagccgca gctgatcaag gattgtttgc tgggacaatt 541921 ggaatgggct ttattgcggc gattctttct tccattatga ataacttgcc gactgttatg 541981 attgacgcat tggccattgc cggtacagat acacatggga tgatgagaga agcgcttatt 542041 tatgcaaatg tgatcggttc agatttaggg cctaaaataa caccgattgg ttccttagcg 542101 acattattat ggcttcatgt tctttcgcac aaaggtatga agatttcctg gggcacgtat 542161 tttaaaacag gaattatcct cacgataccc actttattga tcacacttgt cggcctgtat 542221 atttggctgc tgataatcca ttcttgtttc taaaaggaca aggtcactat atcaaggaaa 542281 acaatgcact ggtaactctt gccgcagcca aatggctgaa gggtggggga gaaaatacct 542341 tggggctaag tggaatgtgt acagcgcagg aatcgaagct caaggatgac atcgagtgct 542401 gtcaaagcaa tgaaagaagc agggattgat atttcaaatc aaacatcgga gaaatttgat 542461 gatccggcaa aagcacacgg aacagaagaa gtgtttccaa agggtccgtg atgaaattgg 542521 tgaccgttta aaacagtttg ctgtaactgg ggaataaaga atcgatatat tcagcgtttt 542581 cttgggttat ataatacaat gtgttgttca acaggtgtct gcgagctgag tgcagacacc 542641 tgtttttgtt tttatttgtc tgagattcgt aacagggaag ttatttagct ggtgacagag 542701 gaaaattgat ttgtgaacag aatcatgaag gagacggtgt tttaaaggag ttgtctgttt 542761 tgcaggaatt aacaaaaaaa aaatacagta gcttaaaaac aatgtttgat gacaaatatt 542821 gtcccacatt tgtctattca atattagacc aaaccattcc gggagctgtt tatgcagatg 542881 atcaaacctt tcctaaatcg ttttttatag gaactgaatc aggcatttat tttattgcgg 542941 gagaccaagg gaatcgggat tttcatgatt tcattgcagg atattatgaa gaacaagtga 543001 aatcatcaaa acgatttacc ttgttttctt ccagtgatac atgggatagc gtactgaaac 543061 ccatactgaa agatgactta aaccaaatga gaagagctgc attttcttat caaccaaaat 543121 ctttcaaaaa gactttgcaa ctgccaaagg ggcttgtatt gaaaagaatt gacgaagaca 543181 tcatttcaca tagcacagcg tttaacagcg cgtattatga ggagtattgg aattctgtct 543241 cacagtttgc ttcaaaaggt tttggatttg ccgtattaca tggcaatcac gtagtaagtg 543301 agtgtacctc tatattttta gggcataatc gagcggaaat ggatatctat acacttgaag 543361 aatatagagg actggggtta gcttattgcg tagcaaatag gtttatagcg ttttgtatgg 543421 aaaatgggat tgttcctagc tgggattgtg atatttgcaa caattcgtcc attgcattag 543481 cagctaaact agggtttaag acggtaacgg aatacactat ttactactct ggctaacctt 543541 aatgaaagaa ccttaaaagg agataccaac cgatgttggt atcttttttg ttttagagtt 543601 tttttaccct tttagcagaa aaatgggtga tgaaaatctt attcatttta tttactttta 543661 ggtaggtaaa acataccccg ccaactgtaa ccactccgcc tagcagagag agcagtgtgg 543721 gtatctcgcc gatccagagc caagatatga tcaaggctaa agccggtgta acataaagtg 543781 aaagggttgc ttctgaagca ccgacgaatg aagtgacata tgctagtgcg aagtaaggaa 543841 taaccgtcgg caataatcct aagtaaacga tagacaaagt tgcgcttatt gaagcgttca 543901 tcatctcttc gcctaagcct ggcagaaaca caagcatagg tattgttccg ccccaaatgg 543961 tgaatgtaac gaatggaata aaaccatatt tttttatata gcgggcttga aaaacgaaat 544021 aaatactctc cgaaaatgct gccagcagga tgaccaagat accgctcatt gaatatgtaa 544081 agtctcccgc cccaaatgca atcaataata cacccaataa actgatcata gagccaagcc 544141 atttcgtaaa tccaaaatgc tctttataaa acaggcggga tagcatggct gagaagatcg 544201 gtgccgtagt aacgagtaag cttgcaactc cggcactaac tgttttttca ccgatgttca 544261 gcaaaatgtg atagaatgca aatcctaaaa accctaaaag aaaaatggca ggaatgtctt 544321 tcaagtcggg taggcgcatc tgagtcaaaa cagcaaaaag caataatgcc atagagccga 544381 ttaacaaacg aaataaagca aggtgttctg gcgtgtaccc ttcaagtcct gcgcgaattc 544441 ccggaaaagc agatgcccat aaaccaatca tgagactatg agatatcatt atttgaactg 544501 ttttctttcg cattcctctc actcctcttt acaaaaacca accagttatt taatgtgttt 544561 ctatactaat aaagatttga tgatatggct tcaaccagtt caatagattt tgacccaacc 544621 aatttatttt aaggagaccg attctatgag ctttccagaa gaaaaaaaga tgaaaaagct 544681 ccctaagtac agacaaatcg ttcattttat taaagagaaa ataggaaatg gagagtggcc 544741 gattggaagc aagattccaa gccagcgcac gcttgcaaaa gattttcagg taaatcggag 544801 cacagtgatt acagcgttag aggaattgat ggccgatggg ctaatagaag gcacaatggg 544861 gaaaggcaca gttgttatca acaacacatg gacactgatg gctaagaatt ctgctcccga 544921 ttgggatcaa tatgtcacct ctggcattca gatgccaagc cgaaaaatcg ttcaagagat 544981 aaatcaatca gaatcaaata cagaccttat acagctcagt aaaggtgaac tttcagctga 545041 gatttttcct ttggctgtta tgaaagagat gatggggaag gtatctcaac acatggaggc 545101 attcggatat gaagaaccaa aaggttactt acctttgagg gaggcattaa gcaactattt 545161 aaaaaccatt ggaatcaacg tctcatcttc ttccattctg attgtctcag gagcgttgca 545221 agccttgcag ctgatatcaa tggggctgtt acaaagagga tcaaccgttt atcttgatca 545281 gccctcctac ctttattcat tacacgtatt tcaatcagct ggtatgaagc tgactggact 545341 tcctatggat aatgaaggac ttttgcctga aaatgttcat ttaacaagag gagagcgggg 545401 aagggctatc ttatatacaa atccatgttt tcacaatccg actggtattc ttatgtctaa 545461 aaagcgacgg gaagaaatcc tagcagtaag tgagaataca cagcttccta ttattgaaga 545521 tgacatttat cgtgagttat ggatcgatga aattccgcca tatcctatta aaacaattga 545581 taaaaatgga cacgtactgt acataggaag tttatcgaaa acattaagcc caggtttgag 545641 gattggatgg atcgtcggac cggaaccggt gattgaacgt ttatctgaca ttaaaatgca 545701 aacagattac ggatccagtt cgctatccca gagagtagcg gcagagtggt ttacttccgg 545761 ccactaccag cagcatgtag aaaaggttag gcagcaatta aaggtgagaa gagaattggc 545821 cttgagtgct ttagaaactc atttgaaaga agtggcgaca tggaatatcc caaaaggagg 545881 gttttttgtc tggataaaaa tattgccttc catatcaatg aaattacttt atactaaagc 545941 cttatcaaaa gggattctga tcaatctcgg cagtatctat gctcaggaaa aagggaatta 546001 tattcgctta tcatatgctt atgcatctct tgaagacctt caaaagggga tttatgagtt 546061 gggtttaatg attaaagaat tggcaagcag gtaactttta tatccttaaa tggatgtttc 546121 actaaaaaag agatcaagcc taatgatcgc ttgatctgat aataacaagg gttactagaa 546181 tagaccaaat catggttcgg tcttaaaata atcatgtctc tgaacgaaaa gtctttccga 546241 cttctcttcc taaaccaaag tagtgtctga aattatagat aagcgggctc catttggaag 546301 ggttgatatg gttttcgtcc agaatgatac tttcctcggc atgaaaatgt agtgcctgcg 546361 tctctacaat tgcgaatgac gattcatatt ctggaagccg aatgtgtttc acttcggctt 546421 cgatttggat agggcattct ttaattcgtg ttggtgatac tgtttttgat tgtaaaggcg 546481 ttaaccctgc tgcctcgtat ttttcttttt tatatgtaaa tccgatctgc ttctttaaag 546541 gcggtatact cttttttccg ctataagatg aaattctttc aacgttttcc cataaatccg 546601 ggccaggcaa gtttatgaca cactctttgt gtctttccaa attgtcgatg gcttttcctc 546661 ccagtcctac tccaaggatt atataatgtc caagagccca agaagaagac ataggactaa 546721 tattagtggt tccatcctca ttcaatgtgg ttagaagaaa tgtcgaggta ccataataca 546781 tgatcttggg tttgatttcc ttaaatcgac gagtgtcttg ttttttgatg tccaacgttt 546841 tttcctcctt gtcacgctta catttatatt gtaaaggatt aacatttcaa ctatcatcga 546901 aatatgaatg taaggaggaa aatcatgaat cctaatattg caaaaatctc ttcgttgcta 546961 tcagatccct cgcgttcttc cattcttctc agtctgatgg atggaaggat acaccctgcg 547021 ggagagcttg catatctcgc taacattaaa cctcaaactg caagttttca cctgaataaa 547081 ttgcttgaag caaagctgat tagcgtagag aagcatggga gacatcggta ttacagattg 547141 gctgactcag atgctgcaaa tgtgatcgaa caattgcttc atattgcgcc taaagcaaaa 547201 gtcaaatctt taaaagagtc aaaagagaaa aaggacttgc atttcgcccg gacctgttat 547261 gatcatttgg caggttatgt gggcgtgcaa atggcacatt cactagttga gcaggggatg 547321 ttaaaaaaag ttgatttaaa ctttgaggtg acttcagagg gtgctttatt cttttcgaag 547381 ttaggcatca atgaagagca acaacggaat aagaggagag cctttgcccg ctgctgtttg 547441 gattggagtg aacggcagca tcatattgca ggagcattag gaaacgccct attggtgcgc 547501 atgttagaag aagaatggat cgttcgtatg cctaaaacga gagcgattag gattacacaa 547561 agcgggaaaa tcgcgtttga aaagcaccta aacgtgaaga tttaggattt tgaagcggaa 547621 acatcagatg atgaggcacg atatctagga ggagtaagat ttgttctaat cttactcctt 547681 cttcttattt tgaagcagct cgattcccca ttgcaataga gatgcggttc caactgttta 547741 tttgattaat gatcagaaca aggtcaacat attgttcctc atcataatgt tcccgcaccc 547801 gatgatatag ctcatcagga acccttttag atggaatgag cgtgatgtgt tcagatagtt 547861 cgagagccgc tttctcttca ggtgagtaaa aatcacattc attccaagca tgtaaacagt 547921 aaattcgctg ttcagtttct cccattttgc gggcatcgga cgtatgcata tctatgcaga 547981 aggcacagcc gttcatttga gagactctga ttttgattag ttctctcgtc gttcggttaa 548041 ttgaggattg tttcgtgtat ttctccatat ccatcatgat tttcatacct tcaggtgcaa 548101 tctcatagta ggacactctt tgactcataa agcaagactc ctttccatag aatacctaga 548161 ttgtatcccg gtattgatca ttttaccaat gtgcggtttg aatgacagct gtttcagcgt 548221 cttttggaaa gaagcttctt tgaataaaaa taagggtagc cagcaatgat gagtggagct 548281 gctaatgcaa gcagtatcca tgagcctgat tggctgtctc tagtgactct aatgaatata 548341 taagtaccga tcagaaaata taataaagca cctagaaacc aatacatgtt cattcctctt 548401 tttccttgct ttttggttgc gcatttttgt ctgtcatatg gcttaatcga tcagggttct 548461 gattttttaa taccttttcg gtccggattc cttttctctt taatgataaa attgtgagat 548521 caatcgattt caatgatgat cattccttca atgaatagta agttccttat gattttaaag 548581 gtaaatttga aaagataaaa cgtacataga ggcagaacgt tcatgtacgt ttgggcaatg 548641 atcacttgtt ggaaactcta atgtttccct gcacctgata ttgttgtgtt ccttctcttc 548701 ctataaaatg attggataca tgtatgtttg cacgttgaaa tatgggttcg attttcatga 548761 atctctattc ggtgaaacag gtaaaggaag tggataaggt ttgcttataa ggaatccttt 548821 taaagataaa tattactcac atgataggcg ggcattaaac atgcttgcac tcagagtgcc 548881 gggcctggct tttattctca tgatctatat agcctctatc gtgctgcaat ttgtttctgg 548941 gggctggtcc attttattgc tttatgcgtt taccatatta atcgccattt ttgctttgct 549001 tcattggcac tcatatcgct gggttaagaa aagagtgatt ctgtatttcg cggtacaagg 549061 tttgatcacc tttgcacttg ctaatctcat gactggcttc tttatacttg tgattatcgg 549121 cctttatgca tttttaattg gacaaattat aggaatggca gacagaagaa ggacttttct 549181 cattctttat ctattgctgc tgctggtcat aaattcggcg tatcaccttc ataaaggtga 549241 agttttgcat tttattgtta ttgctgcgcc gatcatgatt gtcatcatca cttatgccgc 549301 aacatttttt gcccaagtcg atgaaaaaat aaaagctcaa ttgactcttg aaaggctgga 549361 gctggctcat cagcaggtag aacagctgac gctgcagaac gaaagacagc ggatggcccg 549421 agacttacac gatacgcttg ctcaaggtct tgtcagttta aatatgcagc tggatgcgat 549481 tcatgttcat ctcgccaaag gcaacacaga gagagcgaag gaaatcatac aacaatcgat 549541 gaaaagagtg aaaagcacaa tagctgatgc acgttcagct attgacgatc tccgcagcaa 549601 atcagaagaa atcggtgttt taaaagaaag aattacctcg ctaatggatc attttataga 549661 gtcgacaggc atggcttgtt tattagatta cagattgcat caggtgctgg atgtgcgtac 549721 agctgaaaac tgttattaca tcattggaga atgcatgacg aatgcggcaa agcatgctga 549781 ggcgaaaaca atctggatat ccatttggga tgatgaaaag ggaaggctcc atttaacagt 549841 taaggataac ggcaagggat ttgatgttga aaaaggaaag aaaaagagag gacattatgg 549901 gcttcttggc atacaagaac gcgtcagggc aataaatggc caattcaata tcaagagtac 549961 aaaattgaaa ggaacacaaa ttgagatcac tgtaccaatt cagggagaga tgcaagatga 550021 ataaggtttt aatcgttgat gaccatcttg tcgtgaggga aggtctgaag cttttaattg 550081 aaacgaatga tcaatacacc attataggag aggcggaaaa tggaaaagta gcagtccgtc 550141 ttgcagatga attagaaccg gatatcattc tgatggattt gtatatgccg gagatgagcg 550201 ggttagaggc cattaaacaa ataaaagaaa aacacgatac ccccatcatt attttgacta 550261 catataatga agatcactta atgatcgaag ggattgaatt aggagcgaaa ggatatctgt 550321 taaaagatac gagttcagaa accctttttc acacaatgga tgcagccatc agaggaaatg 550381 tgctattgca gcctgatatc cttaaacgtc tgcaagaaat ccaatttgag cggatgaaaa 550441 agcagcgcaa tgagacgcag ctgacagaaa aggaagtcat tgttctaaaa gcaattgcta 550501 aaggtcttaa aagcaaagcg attgcctttg atttgggcgt ctctgagcga acagtaaagt 550561 ccagattaac gtccatttac aataaattag gcgcgaattc aagaactgag gcagtaacga 550621 ttgccatgca aaaaggtatt ctgacaatag acaactaaac tgcatatttg aaaattgccc 550681 aaacgtacat gcccgaatgt acgttttttt catttcattg tcaactacaa tgagaaagaa 550741 tgtgatcaag caatgtgttg aaaggagatt atcatgtcaa aaatgttata tacattagga 550801 ggatgggttg ctcgcaatcg cataaaagca atatgtgcgt ggatcgttgt gttagttgct 550861 gcgataggcc ttgcagtgac cttgaaacca agtttttctg aggatatgtc catacctgac 550921 acaccttcgg aaaaagcgat ggatgtgatt caaaaagaat ttcctcatgg tcctgataaa 550981 gggagcatac gggttatttt cggtgctggt gatggggaga aacttactgg gaagccagca 551041 aaaaaagcaa tagaagatac gttcaaagaa atcagtaaag atgattctgt tgactcgatt 551101 gcaagtcctt ttgtgacagg gacaatcgcg aaagatggca cagttgccta tgctgatatc 551161 cagtataaat catcagcaga tgatataaag gattactcta tcaaacactt aaaagacagt 551221 ttgaaaatgg ctgatgatga aggattgcaa actgagctaa gcggagatgt accgggagcg 551281 gagatggaga taggcggtgt ctctgaaatt gtcggcatta tcttggcttt tgtcgtttta 551341 gccattacat tcggttcttt attaatagca ggtttgccga ttttaactgc actgattggt 551401 ttaggtgtaa gtattggact ggttttgatt gggacacaag tatttgatat tgcttctgtc 551461 agtctttcat tagccggaat gattggcctt gctgttggta ttgattatgc tttatttatt 551521 tttacgaaac accgccagtt tttaggcgaa ggcatacaaa agaatgaatc aattgcgaga 551581 gccgtgggaa cagcgggaag tgcagtggtt tttgccggac ttactgttat cgttgcactt 551641 tgcggattaa ctgtcgttaa cattcctttt atgtctgcga tggggctgac agcagggctt 551701 agtgtactga tggctgtttt ggcttccatc acacttgtgc ctgcggtctt atcgattgca 551761 gggaagcgga tgattccgaa atcaaacaag aaaatagaaa aacaaagcac tgaaacaaat 551821 gtctggggac gctttgtcac caaaaatcct atcatgctaa gtgtatgcag cattctgatt 551881 ttgatcgtca ttagtatccc atctatgcat ttggaactgg gcttgcctga tgctgggatg 551941 aaagctaagg ataatccgga tcgccgggca tatgacttgc ttgccgaagg ctttggagaa 552001 ggatttaatg gccaattaac aatcgtagcg gatgccacaa atgctacaga aaataaggcg 552061 gaggctttcg cagatgcagt gaaagaaata aagggcttag accatgtagc aagtgtcact 552121 cctgcaatgc ctaataaaga agggaacttt gccatcatta cggtcgttcc tgaaacaggt 552181 ccaaatgatg tcacaacgaa agatttggta catgatgtac gcagtttatc agataaaaac 552241 ggagtagatt tgcttgttac tggatcaact gcagtgaata ttgacatttc agatcgcctg 552301 aatgatgcga taccggtgtt tgctgtactt attgttggct ttgcgtttgt attgctgacc 552361 atcgttttcc gttcgctgct tgtgccgctt gttgctgttg caggtttcat gttgacgatg 552421 acagccactc ttggaatctg tgtatttgtc ttgcaagacg ggaatctcat cgactttttc 552481 aaaatacctg aaaaagggcc gatactcgcg ttcctgccga ttttatcgat tgggattctg 552541 ttcgggttag ccatggatta tcaagtattc cttgtcagca gaatgcgtga agaatatgta 552601 aaaacaaaca atccagtaca agccattcag gctggattaa aacacagtgg tcctgttgtt 552661 acagcagccg gcttgatcat gatcttcgtt tttgcaggat ttatctttgc aggcgaagct 552721 tctattaaag ccaatgggct ggctctttcc tttggtgtac tctttgatgc ctttattgta 552781 agaatgacac tgattccaag tgtcatgaag ctgatgggga atgcagcctg gtatttgccg 552841 aaatggttag acaagattat tccgaatgtg gatatagaag ggcatcaact gacaaaggaa 552901 atacagccgg aaatagatca tgaacaaaag aaacaaatca gtgtgtaata gaaaaagcag 552961 atcttttatg atctgctctt ttgcttatgg tagtatttag aagatgaagt cggcagttaa 553021 aaggagacgc ttatggcgcc atcactcatt ttcgatatgg atggaacttt gtttcatatt 553081 ggcagaagct gcatcatact agcaggcatc ccaggagaag tgacatgatt ttttgacttt 553141 gcattcacta cttgatgcca aggatcttga gaatccttct tgaaaataaa ggattttaca 553201 actgatcata taagaaacct aaagaaacaa gcacacaaaa ccagctgcgg gttttgtcca 553261 agaaaaatag agtccataag agggactcta ttttttgaag tgcccggcta gaagcatatt 553321 gcaggacttt atgaatgcaa atcactatct tataagccct taccgtgaaa tgcctgtttc 553381 tgcattgaaa aaacgcatta cacgttcatt tacgtaagtg ggttgttcca tcgataaaac 553441 atgtccggca tttttaatga cttccgcctc aatatctgga acgaatgaag aggctcggtg 553501 cagggctgag tggggatcat agatgacttc atgttcacca agtaataata ggataggaac 553561 tcttgctgaa cgtaattcct catcggtaaa aacatacgga aatccgtcgg cattaggatt 553621 tggatttctt gatccatcct gccacattac ccctgcctta aactgcttca caaaaatcgg 553681 gtgcagcaca ttctgatcat tcatcatcca atttaagaat gtttcaactc catttgacgc 553741 tgtaaggcca agagcgtatt tgtagaaatc gtgatgaaat ggcaaaaacg tttctgccgg 553801 actcagtata gctgcgcttt ttactctctc aggcatacgt aaaaggaaat tcatcgtatg 553861 gagaccgcca agcgaaagtc cgatcatgtg ggacttttcg atccccagat tgtcaaacac 553921 atcaagaagc caattggcgt aatccgttct tgtaccgctt acattctcag gaatactctt 553981 gtttttatca cctatgatat caactgcata agttctgtat ttactgctcc aatcggcgat 554041 gttgggatac cacatcgtcg agctgaataa tgctccgtgg agtaatacaa gcggcggggc 554101 atcctctggg ccgcttgcaa tcacatgtgt ttgaccaaaa cgagtagata tatagaatga 554161 tttacaacgg accggccaaa gactaaggct ttcattataa gtttgataat agcggatacc 554221 gttgtcactt aattcgggaa tactagatga atggtttgac atacaaatgc ccctcccaat 554281 tttgtttaaa tgaatgtgcc gtttcgtgat ggggaatctg attttgatat aacagacttt 554341 atttacaata taatacagtt gttattagac gtcaaatcca agatgaaaag gaaaaaaacg 554401 attgaaacag attattgaaa atcaatataa cagaatatta acctcctttg tggagccgct 554461 tcattaaaac cgcaatccaa atgcatgaat cacaaaaatc acaacaggag ggatcaggag 554521 ggaaggcagc agattcagtg ttttgaactt cttgattcca agaatgctta gacctgaact 554581 gaggatgagt atgcctccca caattgtgat ttcattaata aggtctgtat tgattgcgct 554641 ctccattact tgtgcaaata aatagatgga gccctgccag gaaaataata caagtgcggc 554701 agccgctatt ccaaaaccaa aagttgaagc gagcacaatg gaggtgatcc catctaacat 554761 cccgtttgtc agaaggtatg tataatctcc atgcaaagcg gcttcaacag ggcctaatat 554821 tgacagcgaa cctatacaaa ataataagac cgcagttgat aagccctctg ctaaattgct 554881 tttagaaaat ttgttcacca gcttgttgaa tcgtaattct aaattgatga tctggcctag 554941 caaacctcca atggctaaac tcacgatgaa tagaatgggg tatttactat caggcaaatg 555001 ctgtgtaatg gcgttgatcc ccagtgcgac cgcagcgaat cccattgcct gcatcaaaat 555061 atcctggtat tcatctttaa tgcctttttt gaatatcccc ccgattatgc ttcctgcaat 555121 gatcatcact gtgttaaaaa tcgttccaaa cataagcttt ctcctccaaa aatcattcct 555181 gcataaaaaa taaaccctct agttagtaga gagtcaaggg agatcaaaac atattcatga 555241 gattatttga tgggcagcag gatttcagtc acgtaattat ctaggttatt cgtaatgcca 555301 taatcaatga gtgtgatttc gattgagtcc cctgctacct cataatgatg ttctttcata 555361 tatgccagta attttttgta gtatggttcg gcttctggat gtgacccttt aaacctaatt 555421 tgcagatatt ctcttgaagg aaagatgatt tctgaagaag ttttttcatt ttcatcttca 555481 agaatcataa atatactgga atatttgtca aactgttttg ctttcacatt tgctgcagaa 555541 atggataaac caatcttgcc tatgaatata tcttcgttta cattcaggtg ggttctcaat 555601 tcagctaacg aatgttcgat atcatggccg agaacatatt catgctgcaa ataggccaca 555661 cgcattgcgg gaagtttgat ttttgaaatt tgatgtaacg gcatgttaac ggcatcttct 555721 atatgtgtga tgcgtcggga gatctttcgt tcaatgcgtt ccaattcttt cttcttgcga 555781 tcaatttcaa cctgctggct ttttagtaaa tgaagaagag tgtttgtatt ttgagagtta 555841 taaaaatcaa gaagcttatt gattggcagg cctagggccc tcaaatactt gatggtatcc 555901 agccgctcaa actgttgggt agaataatat ctatagttcg tttgctcatc tttatattcc 555961 ggtttcaaaa ggccgatttc atcataatac cgaagagcag agattttcac attgaataac 556021 tttgacactt ctccaatcga aaaaaattcc ttcattctaa caacctttct gtcctatgat 556081 tgatatacac acattatata gtacggcgag tactaaaggt aaagtttgca gcataaagaa 556141 aaaactcctt ctaaaaagga gcttttcatt cttcgaaata aggatttaca tggatgagca 556201 cttcttctac atctgaaaac tgtcttttga tttcatttcg aatttcgcgg gcaatgtcgt 556261 gtccctgctt aattgtcaaa tcatgatcca aagataaacg gacatcaagc aatttatagt 556321 ggccatgttc tcgcgcgcgg attctatcaa ttcgttttac ctgatcacat tgaaaaataa 556381 cagctttata ttcctctatc agctcgggat caacactctt ttccatgagc acatcaacag 556441 acggcctgat taattccatt gaaatcttaa aaatgaggta agcaacgatt gcactggcaa 556501 tggcatcggc gtacaacaga taggaccatc cacggctgtt tccgatgata gccaacagga 556561 cgccgataaa agcggcaaga gaggcaacga tatcgccttt atgatcgtac gcaatcgcta 556621 taatcgcttt gctgttccat tttttccctt gctttataga ataacgatat aagatttcct 556681 tagccacgta cgaaatcaga gccgcaaaca atgcgctgta ttggggaacg cttggccctt 556741 taacaaagga cagaatcgct tctatgagga tataaacgga tacgatcact aagataattc 556801 ctacaatcgc ctcactaatg acttcagctt ttccgtgacc aaaaggatgg tcttgatcgg 556861 gcggtttatt ggaaattccg atcactgcca agactgcaat cgaagcaacg acatctgccg 556921 cggaatgtat tccgtctgca aacacggctt cactatcgcc taccagccca aaaaagacct 556981 ttcctgccat taagatcaga ttggcgatca atgcaatcaa agcaactttt ctgcttattt 557041 gttctctttc acttgccatt ttttcctcct ataaaactgc acaaaaaaat aggagtgctc 557101 tatatacgct ctccgtatcc tttcctgtgt aatcactttg tttatcatac caattcaatt 557161 tcgagtgggt ctatagcaac gttgtttcct gtttactaat aaataaggtg acagaaaaaa 557221 agttggagct atgctaaaaa ggtcatacag caaacaaatg agttcttatg taacaacagt 557281 gatgattcgc tattaaaatg ctgccgtcag tgaaaaattt ccacctaatt ttcaaaaacc 557341 tattgacatg agaagatctg tattttacta ttatctcata ttcaagatat tttaatttga 557401 gatatttggt cggaaagatc agcgatcaag cgcaactcta agtgttcaat cgttgtcagt 557461 tcttttacac aatattcaat atgatttttt ataacataat atctcgaatt cgagataaaa 557521 gggagtgtag cgtaatggct gaatttactc atttagtcaa tgaaagacga tctgcaagca 557581 attttctttc aggtcatcca atcacaaaag aagatctcaa tgagatgttt gaattggttg 557641 cattggcacc atcggctttt aatttgcagc atacaaaata tgtgacggtt cttgaccagg 557701 acgtaaagga aaagctgaag caggccgcaa acggacaata taaagtggtt agctcttctg 557761 cggttctctt ggtattaggg gataagcagg catatcaaca agcggccgat atctatgaag 557821 gtttaaaggt attggggata ttaaataagc aagagtatga ccacatggtg caagacaccg 557881 tttcgtttta tgaaaacagg ggagaacaat ttaagagaga tgaggcgata aggaatgctt 557941 cactttctgc gatgatgttt atgctgagtg ctaaggaaaa aggctgggat acctgcccga 558001 tgatcggctt tgatgcggaa gccgtaaaac ggattttgaa catagacgac caatttgagg 558061 ttgtcatgat gattacgatt ggaaaagaaa aaacagagag cagaagaccg cgcggctacc 558121 ggaagcctgt gaatgagttt gttgagtata tgtaaaagga gcggataaaa atggctaaaa 558181 aaacgatggg aattcatcat attacagcga ttgtcggtca ccctcaagag aacacagatt 558241 tttacgcagg agtgcttggg cttcgtttgg tcaagcaaac tgtcaatttt gatgacccag 558301 gtacgtatca tctttatttt gggaatgaag gcgggaagcc gggaacaatc attaccttct 558361 ttccgtgggc cggagcccgc caaggcgtca ttggagacgg tcaagttggc gtgacttcgt 558421 atgtcgtgcc gaaaggggct atggcatttt gggaaaagag actagaaaag ttcaacgttc 558481 cctacaccaa aatcgagcgc tttggggaac aatatgtaga atttgatgat cctcatggac 558541 tgcacttaga aatcgtggaa agagaagaag gagaggctaa tacgtggact ttcggagaag 558601 taacgcccga tgttgccatt aaaggttttg ggggtgcaac cctattatca gagcagcctg 558661 acaaaaccgc tgacctttta gaaaacatca tggggctgga gcgagtcggc aaagaaggag 558721 acttcgttcg ttatcgttcc gccggtgata tcggaaatgt gattgacctt aagttaacgc 558781 ctattggccg cgggcaaatg ggggccggaa cggtgcatca catcgcttgg cgggctaacg 558841 atgatgaaga tcagttagat tggcaaagat atattgcttc ccacggatat ggtgtaactc 558901 ctgttcggga tagaaactac tttaatgcca tttacttcag ggaacacggg gaaatcctgt 558961 ttgaaatcgc aactgatccc ccaggctttg cacatgatga aacacaggaa acaatgggcg 559021 aaaaactgat gctgcctgtg caatatgaac cgcatcgcac acaaattgaa caagggctgc 559081 tgccgtttga agtaagagag ttagattgat ttgacacata aaaaataaag aaacatatat 559141 tcaattgatg attgctggat ggtactgtca gcaaagaatc agataaaatc aaagatgagg 559201 agagatacaa atggaagatg caggactgtt gcttattcgt ataatgattg gtgtggtgtt 559261 tttgttttat ggcacacaaa aattattcgg ctggtttggc ggatacggga ttaaaggaac 559321 cggacaatgg ttcgaatcaa ttggggtgaa accaggaaac gttgcggccg ctctatcagg 559381 tcttggggag ttagtaagcg gaattctatt tattttaggc gtattcctcc cgcttggagc 559441 tgctatcata acaatcatca tgttaggtgc tatcgtaaaa gtccatggag cgaaaggttt 559501 tgcgaatggc gccggaggtt ttgaatataa cctggtgctc attgcagttt ccataggggt 559561 tgcactcatc ggttcaggag cttacgcttt gcatttttaa tacgaaagta tgtaagaaca 559621 gttgctgctt gtcagtaact gttcttttat tttcacattt tcggcaagct tgcaggtact 559681 ctgcaaagca aaaaagcgga tatcataaat ataaatctgt atagtgaatg atacgtattg 559741 atgagcttgg tcatgaaaaa cagacctatt tgaaggagta aatggatgaa agagatgaca 559801 ggattacatt cattagtttc tatagaaaac tttatcaaac agcacaaatt cagttttatt 559861 tatatatcaa ggcctggctg tacagtatgt cacgcagttc tgccccagct cagaatagta 559921 ttggatcagt ttccaaacat caaattgggg catatcaatg ctgacgatgt agcagaggtc 559981 gccggcagat tttcagtttt caccgttcct gtgcttcttt tgttcattga tgggactgag 560041 tttctaagag aagcccgttt tgttcatttt gaacagcttg aacaaaagct gaaaagggtt 560101 tatcgattat atgaaggcga ataaaggaat aaggcaaaaa aagaactcaa atgagttctt 560161 tttttattct tcactaggcg aagaagggtt atcaacctgc ccttgatcac ttgtatcatt 560221 atcacaactt gctgaaataa taattgaatg agaaggagag taatctccta atgtgaaatt 560281 cactccgtaa tttttgctgt tcgcagtatg gctgttttgc aagttttgtc cgatatctgt 560341 attggcgttt tgtgtcattc catttatcgt gagatttgag atgttgattt gagatcgcat 560401 gcttcaaaaa ctcctttcac tcagaagtag ctgtcataaa ggacgctggc agtctattta 560461 cttctatgat attgcgtttt tatatcattg catcaacata atggtaaaaa taatagcgag 560521 tgaatgatca tcttttgaag atgatcaacc tatcagcaga aataaagccg cctgataaag 560581 aggcggcaga tcgttatatg tcatctatga atttgatgta tcgtttttcg tttgcctgaa 560641 ggataagata gtcgttttta atgatgagta ggagcctata gcagcgtagc cataaaacca 560701 gcccataaat acgccagaaa agaggctgtg tcgatggctt atgaaaacag aaatgacaag 560761 gcctgttatt aaggcaactg acggtacaaa agttttgggg attttcaata atattttgag 560821 gatttgggtt atcaatatga tgattggaac agctatcaca gcatcccaaa agttcgtgtg 560881 aataattgga aaagccatac ggcacctcat gaagtgttta tttcttaatt tttacgctaa 560941 aagcttggaa agcagctctt ggatcgcata tgttacattt tgggcttgat tggcggagct 561001 tgtttggctt aaagcattgg attcaaaaac caaacctgta ttactcccac cggaaccctc 561061 tgttgtttta gacacagaga acgggctgat ggaaactgca aatccgttat taaaaacgct 561121 gttcccggat atcgaatgaa tataaactgg gaatttcatc attcatctct cctctctgtt 561181 atgactgttt atacaatatg gtgtgtgagc agcagttgct taaacaaaac ggcaaaaact 561241 ttcagtaaga gacaaaaacc tgcaaaatgc cacaagcgcc ttttgttaat gcagcttttt 561301 agggacgttt tttttatttt ttttgccaac ttcatcaaaa atattctgat tgccagactg 561361 ggcttgtccg tccttattta tgaaatcggg gtgaatgagt tttttcagat ccctgactgt 561421 taaaggcttg gcgtcatcag ttaattctat tcctaattgc ccgtttgcct ctaatgtcgc 561481 aattttgaca tcttgtatag ccgtaacgcc gtgaagcctt agctgcattt caagctggtc 561541 agctgtaagt ctcatcttct ttaagttttc gatatgaagc tgtccgtttt caatgacgat 561601 ttttgctttt ccggttaaca tcttttcaat ggtgttcgat ttcatttgga tccattccat 561661 aacgatgagt gtgcttgtga aaattgccgc tgcaattaat gttttgaaga ggctgtactc 561721 gatgattggc tgaacgataa tagttccgat cgaaatcatg acaaccgttt gagtcgacgt 561781 catttgtgcg attgatttcc ttcctgaaat tctcagcaaa atgaccccgg ctacaatgag 561841 aacaagagat tcccaagtga aattcatgct accacctgac caatgatgaa ttagatttgt 561901 catgggattg gcttttcttc cggccaatcg caatttaata tatccgaaag gcagtcggtt 561961 cattctgtcc tgaaccgaac aatatttttg gtatagatgg atatattaag ccaaacaatg 562021 atagcaacag gagttttttg gccgaaacaa tctgggaagc ggggagcgcc ataacatgat 562081 tgaacttgaa gttgtcatta gaacggttgc cagctttggc ttgctgttaa tcgcagaacg 562141 aattttaggc aaacagacaa tctctcaaat gacgattttt gattttattg cggcgatcac 562201 actaggggcg attgctgccg gattagctta caatacttca ataaaaccgc acaatatggc 562261 catttcgttt agtatttttg tgctaaccat ttttctaatt tcgtttctgt cgataaagaa 562321 caggaagctg aggaaatttt ttgccggaga tccaacagtg ctgattcaaa acgggaagat 562381 acttgaatca aatatgagga aaatgcgtta cacacttgat tatttaaatc agcaattacg 562441 ggaaaaagaa atatttaata tcgaagaagt tctttttgcc attcttgaaa cgaatggtca 562501 gctgactgtg ttaagaaaac cgcaattccg gcatgtgacc aaacaggatt taatgattgc 562561 ggtaaaccaa gaacaaaggc ttccgataga acttattatg gacggagaaa tcattgagaa 562621 taatttaaag cagaatcgtt tgacggaatc ctggcttttg gaagaattgc gaaaaagaga 562681 cataaaggtg aaagagaccg tgtacgcagt gctgctgggt aatggggata tttatgtgga 562741 tcaatataaa gaccatatat cagtccctat ggataaggaa tgaaggaaca atcaatctta 562801 aagcccctta ttgaacgcaa cggtttcaac ttgtcttggg tacgaaatat gcagaagccc 562861 gtttaacagc tgaatctgta acaaatgagt ttcagcggct tcgggaagct gaatgattcg 562921 ctcaatttct ccgtaatacc gttcacgcag cacttccatt tcggctggaa aaacaggcgt 562981 gatcgttcct ttgatcagca gctgggtttt agacagtaaa cggatcgtta attcttcctc 563041 atacacaccg ggcatttcca caatgataaa attatattcc tcatcttgat aaaagtcgta 563101 aacaaacgta gaagcttcgg aatcaaaaaa atgttccggg gctttatatt tgagcacatt 563161 tgtccaaaag tcactttgtt tatattcatt cgtaatctca agccactttc gaattttttc 563221 gaaatccata tgagattctc cttaaatttg atttgaaatc ggcgcagaag ggtttccgat 563281 ttggtcttgg tcactaacgt ctgaatcaat atttccagtg tttaaaagtg aagacgtagg 563341 cgaaagatcc cctaaggaaa agtttgctcc aaaatatttg ctgttcgcag tatggctgtt 563401 gtgcacagtc ggaccgacat ctatatttcc gttttgcgtg acgccgttga tcttaatatt 563461 tgcgatatta atttgatatg gcatagacga aaccccttta atctaaaatt ggcggtggtg 563521 caatcggagg agcattaacg ttggatgtat cagagttgcc gatagatgtc tggtcattta 563581 catcaggatc gtttaagaag ttttccatta cggattctgt aggtgatgta tcaccgaaag 563641 aagagttggt cccttgagat ttttgattgt tggtagggct gttataagca gcttcgccta 563701 ttgtaattga accattgccc gaaatactgt tgatcttcaa ataatatagg ttgattactg 563761 tagacggcat cccatcacac ccttccatct ttctgtacag tacattatgc gccgctgcac 563821 ccaattgttc cttgcattta cgggcaaaac tctatctggc cccggagtga tgctcaatta 563881 tcagtgaatg aaaagccatt gatataggaa tcaatgaatt gattcagtta ttcgaaatgc 563941 atgagacctt ttaataaagg aagctggcaa acaggatcag tttgaaataa ttgacaatga 564001 agctaatgcc atgaaataat actcgtgagt aacattactc gtgggtatta tttttggggt 564061 ggtcctagtt gaaaagtaaa ggagtagaaa gccgaaaacg attacttaaa gctgccgcta 564121 atgaattttc ggttcgggga ttccatgacg cgaaggtaag tgaaattgtg aaaaaagctg 564181 ggttcacgca gccttcattt tacctgtact ttcaaagcaa agaagccatc tttgccgagt 564241 taataaccga ttttcactct cgagtcagaa agctgacaga gtcacttctt ctggaaaacg 564301 gattaaacac ggaggatgtg tcaaaacggg tactgctagc tgtagagact gtttttcaat 564361 ttttggatga ggacaaggat ttaaccaaga tcggcttttt tctcaacccg gaagcaaaac 564421 aaatgaaaaa agacttggcg atggttttga aagagaactt agaagcagaa cagcggcttg 564481 gctattttca ctctgaactg gatatggaaa ctgtcgctga gtgtttggtc ggcatgattg 564541 aacatttaac cgaatcattt ttgttaaccg gaatcaaaga tccggcaagc ctcgcagcag 564601 aggttgtgaa tcttttaatt tacgggatgc ttccgaaagg gaatgatgta agatgatatc 564661 tattatgatg aaagtcagtt tggcagtttt tatgcttgcg ggaggcatca taaaggtaag 564721 ccgcgttccc tttcaagttg agcattggcg gcattatcaa tatccattat ggtttctgac 564781 tgttactggc attcttgaaa tagccggggc acttgctatg acagcgggaa tttggaatcg 564841 gtatgcagca attggagcag gtgttctgtt tgtcgttctc atggcgggag caattcatgc 564901 gcatatgttt cgagcaagac aatctgtcat catggcgata caagcgatga tttgtttgat 564961 tgtttcaatc atgatcatca tggggagtta cacgtaagct tttcactaat gtttaagaac 565021 aagcccattt gcaggaaatc tccttttctt atcgaataat agaaagtcca ggaattaact 565081 gaatcagtaa aatagagctc catttctgtg ttattcgtcc ggcatcagct gggctttttt 565141 tataaaggag gaatacagga tggcattcac tttggaagac atgactgagg aagagttcga 565201 agcctttcgc gggatgtccg tgcaaaattt tgcgaaacaa aacataacgt caggaacttg 565261 gacggaaaaa gaggcatttg agaaatcgga gcaggcatat gagaacatga ttccgaatgg 565321 gcgagacagc agcaatcatt atttttggaa catcacaaat gaccaaggag aaagaatggg 565381 ctggctctgg ctgtatgctg atccattaca tccgcaaaag gaagcgttta tctattcctt 565441 tggattgtat gaagcctttc gcggaaaagg acttgctcaa ttggcgcttc aaacgcttga 565501 tgaaagagca agagagcttg gtgcggaaag gctggctcta catgtatttg cacacaacga 565561 gacagccgtc tatctttatc agaagatggg ctatgccatg accaatatac gtatgcggaa 565621 acagctatgc tgaaaagccg cttacgttac ccaaatacaa catgcctatc tggaagcggt 565681 ggcagggtac tataagtcat cattagaaag attaaggtca tgggaggctt gaacatataa 565741 agaaaaagga caacagctgt tgtccttttc aatgccgctt gaactttctc cctcagtctt 565801 ttttgtcttg atgatccagc tcttttattc gtttcgtaag ctcattgaaa gcctgatcaa 565861 gctccttata ccctttatca tttggcgtca taaaactgag ctttcccagc acttcttgtc 565921 tttctgtctc aagctttaac cgaagctcct cccgctcatt tctttctgaa ggaacgtcgt 565981 ttaactgctt ttcgatgccg ttgtttgaga tgacgagttt actgtttgtt gttttttcga 566041 gaaagtatcg gtcatgtgaa accgccagca atgtgccgct gtattgtgac agtgtttctt 566101 ccagctgttc gcgtgacggc aggtcgagat ggtttgtcgg ctcatctaaa atcagcacgt 566161 ctttttcctc cagaatatat gccatcagct tgatctttac acgctcaccc atactcatat 566221 gcttgatcgg ttcagtccat tgggcggctg taaaacctaa gtgcctcatc agattttgaa 566281 cgtgccccct tgctttgaat gtttcattct caaataactc ttccggtgtt tgttctaaag 566341 gcaaatcaaa cacctcctgc gttaaatagc cgatgtttgc ggacggcgac acccatacac 566401 ttccttctgc tgtttcctgt cccagaatga tgttcagtaa tgtcgttttt ccgctgccat 566461 tggggcctat gatcgcaacc ttttcgccgt gctgaattgt aaagtttgcg tttttaaaga 566521 gagtcctttc tccaaacgct tttgttacat tctgaacttc taaaaaacgt tttcctgttt 566581 tgtgggttgt atcgattgaa aagcggactg tatattctgg ggtaacgggt tccgcctttg 566641 ctttttcaag ctctttttca agccgcttct gcttggattt tatctgggca tccgtacgct 566701 tcgcttttac ccggtgatat tctttaaacc cttccttttt cgtcgattga gcatgggctt 566761 tttccgacca agaagcgagc ccattcattt gtgcttcaat ccgttcaacc attttttgct 566821 gcttttcata ttcacgctgc tgggtgagtc ttttcttctc ccggaacttc atatacccgg 566881 agtaattccc tttgaattca atcagcgtct gatcctcaag cgaccatatt tttgttgcgg 566941 cttcgtctaa aaaatatcga tcgtgagaaa cgagaatcac agtgccgtta taatgtttca 567001 gctgttggat gagaaattgc aagctttttt catcaaggtg gtttgtcggt tcatctaaca 567061 gcagcagatc tgcatcctct gatagtcctt tcgccagccg cgctttcagt ttttcaccgc 567121 cgcttaactg atgaaaatca cgaagaggca catgccattt ctccagtaac ttcttttcgg 567181 caggtgtctg atccgcaaag gaatacgccg cggtttcctg ttcaaccaaa gccagtttta 567241 tatccttccg aaggatttga ccctgtgcag gggctaagtc attgtgaatg aggtgcagca 567301 acgtagattt cccagcgccg tttttgccga taatcccaat gatatctcct tgctgaacac 567361 tggcgtttac atgtttaaaa acagtttgat cctttacttc atagctaacg tttgttaatg 567421 ttacgatctc tttcatccat atccctcgct ttaaagggag aataaaaaaa tcctcccaaa 567481 tgtgttggaa ggattagccg tgcctgtgca tgatcaaata agctattttt tataaatagc 567541 agtgtcgtat atatagaaaa tgggcagact aatcctattt tttgatttga aatattgatt 567601 tcaaacggta aaaataagat tagttaatca ttgtccaccc atcatccctt cttgttttga 567661 ttacaaacac tatagcatac ctttaaattc aaaagcaaag gtcattttca tcaaaaaaac 567721 tcctgctctc atttttgagg caggagtttt gagtcttatt gatgcttcgc ttttctcact 567781 ttataaatca caatcagcaa aataaaccaa accggtgtga caaataagga aacacgagta 567841 tcctgtgcca gtgccagcac aaccagaaca aacgccagga acgcaagaat caggtaattt 567901 gtaaacggat aaagcggaag cttaaacttg tttgttttcg ctaattcagg tcttgttttg 567961 cggtatttca tatggcagat gaccgtaatc ccccaaatgt agataaagca tacggttgaa 568021 atacttgtga tcagggtgaa tacgccttct ggcatgatgt agtttaacgt aacaccgatt 568081 aaaatcacga tagctgaaaa gaataaagca tttctaggca ctttacgctg agtcagtttc 568141 gccattgact caggcgcatt gtgatctttc gccagggaat agaccatacg gcttgtactg 568201 aatacagcgc tgttgcatgc tgaagcagcg gatgtcaaca caacaaagtt gataatactt 568261 gcagccccga cgatgccaac agcgacaaat acttgtacga atgggctttc gctgggattg 568321 atgatatccc aaggatagat gctcataatc acgagaagag ccccgatata aaaaagcagc 568381 acacggacag gaatattgtt gatcgcctta gggattactt tttcagggtt ttctgtttca 568441 ccggccgtaa gcccgacaag ctcaatgccg acaaaagcaa acacaaccat ctggaacgag 568501 aggataaacc cgtgcatgcc attcgggaac aggcctccgt ggctccagag gtttgtgaag 568561 ctggacactc ctgagcttgt ggaaaagcct ttgaaaatca tcacaaggcc aatgacgatt 568621 aacgccaaaa tggcaatgac tttaatcaaa gcgaaccaaa attctaattc tccaaaaagc 568681 ttgactgtcg ccagattcat aatcagtaaa ataataagag cgattaagcc aggcacccat 568741 tgcggcacac ccgggagcca atattgagtg tagagcccga ctgctgtcag atcagccatc 568801 gcaatggaaa tccagcagaa ccaatatgtc cagccggtga taaaagctgc catatcgcct 568861 aggtagtctt gtacaaaatc cacaaaagag tgatagttca agtttgataa cagcagttca 568921 cccagcgatc tcataattaa aaagcaaatg atccctgtga tcatataagc aaataaaatc 568981 gaaggtccgg caaaatgaat cgatttgccc gagccgagaa ataagcctgt cccaatggct 569041 ccgccgatgg cgatgagctg gatatgcctg tttttcaagc ctctctgcaa cgtttgctga 569101 tttatattgt ctttcgtcat gtcgtctgtc actttatgtg ttcctccatt gaaaattgtt 569161 tattgagtca gcaatctatt tttaatgatt attataacac taaaatttct atctttttta 569221 ctaaaaaagg attgatgaaa agaattttaa tgtgatttgg actatttccc gaaaaaagcg 569281 gctccattta gggagccgct tttttatgct ttttcagttt ttgtcataaa caggtagagc 569341 ccgtaatctg tcggtgcgga tgcgtagcct gcctgccgca gcattgctgt gatattgccg 569401 cggtggtatg tcccgtgatt gacaacgtgg ggaagcagtt cggaaacagt tgttttcatg 569461 attccgcttg agggattttg aatctggagt ggcttattga gctgttcttt ttgctgtaaa 569521 aatagtatat agcgctcgga taacctcaga aaaaggtctt ccatttcctc tatttcttta 569581 gcctctgtct gttctttaag ctgttcagct aaagccaacg catcgctcaa ggttttgccg 569641 gaaaacactt caatccagcc gagatcagaa agataaacat gagacaatac atgggatatt 569701 gacggaaaca cgctttgaat ttcttgatgg tatatctctt ttggaagctc ttttaatcgg 569761 ttgaatattt gttgattggc ccagacgtta tattcataca atttgaatgc aaaatctgac 569821 atgttaaaat tccccctttc gtgtgtatag ctttcattat acacgaacat gagttcttat 569881 gtagagtgct cgaaaataaa atttgttgac atatatagtt tagaggaata aactaattga 569941 cattgaacat aaagtttagc ggggtaaact ataatgagga ggggaagata ttgaatgaac 570001 aaaagctatg tcaggcgata aacctgtttg tggaagtcct gcttgaaggg acagaatttg 570061 tgcatcgtga aatcaatcag gatgtcttca agcatatctc aagggaacag gcagacctgt 570121 tgaaaatttt aaaagtcaag ggcccaacct ctcccggcag cctggccatg taccaaaatg 570181 tacataagag cgcgatctct aacagactga aaaagctgct cgaaaaggga ttggttcaat 570241 gggacgactg tccggaaaaa agtgataggc gctctaagct tattaacatt acacccagtg 570301 gtgaacacat actagaagaa ttagattctg ccatctttaa cgcgctcaaa ccgttgattg 570361 atgatataga tgaggaacac ttacattcta tcatcgagat attcaccatt ttaaaaagca 570421 aatttaaagg aggagattct gccgaatgag agcaatcatc aaattcaagt gggcaattgc 570481 agccatagta ttagcactta ccgtcgtttt gagtttgttt tctccgaact taacggagct 570541 ggccaatcaa aaggggcagg cccagcttcc cgctgatgct gtttcagaaa gggcaaacgc 570601 cattttaaaa caagcgggag aagacaataa ttcgatcagt gtagtcttta cattagacaa 570661 cgctataaag aaagaaacag agaatcagct ccggataata attgataaaa tcaaaaagat 570721 cgacggtgta gaagaggtaa catctcctct gtcagcggaa aaagaagtca aagaccagtt 570781 gatgtcgaaa gacaagaaaa ccgttctcat gcctgtcacg attacaggtt ctgataaaaa 570841 ggcggaaaaa attgcggacg agatttatca aatcgttcct gatgacttga cggcatatat 570901 tacgggagct tcccttatca accaggattt cgctcacagc tcagaggaag ggcttaagaa 570961 aacggaagtg ataacagtct gcctgatcat cggtttactg ttgatcgtgt tccgatctgt 571021 tgtgacgcct tttatcccga ttgtggttgt cggtttttct tatctgatca gtcaatctat 571081 actgggcatc cttgtataca atgttgattt tcctatctcg acgtttacgc aaaccttctt 571141 agttgcgatc ctgttcggca ttggaacaga ttactgcata ctgcttctta cacggttccg 571201 tgaagaattg gcaaacgggc atgataaaaa agaagcggcg cttatcgctt accgcacagg 571261 gggaaaaacc ttatttatca gcggatttgc ggtattgatc ggattttccg ccttaggatt 571321 tgcgaagttt gcgattttcc aatccgcagt aggggtagca gtcggtgtgg gaattttaat 571381 gatcatcctc tacacactgc tgccattatt tatggtgacg ctgggtgaaa aattattctg 571441 gccttctaag aaagtgctgt cacacagtga taacaaacta tgggcgtttc tcggcagaca 571501 ctccgttgcg cgtccgtttc tgttcattgt catcacggtg gtgattacgc ttccgttcat 571561 cttgacctat gatgaccaga tttcattcga ctcaactgcg gaaatcagca gcgattataa 571621 atctataaaa gctctcgagg ccattaagga tggattcggg gaaggaaaag cgttcccgat 571681 caatgttgtc gtaaaaggag acaaagatct tacaacagct gatacaatcc cctatctagg 571741 aaatatcagc aaagcgatcg agaaagttga tcatgttgac tctgttatga ccattacgca 571801 gccgactggt aaaaaaatca aagatttata tattgataac cagctaggat cggtttcaga 571861 cgggctggat aagacggtga aagggattgc cgatgtccaa agcggattaa cggatataga 571921 aaacggactg aatcaaatgg cagggcaaac cggctcggcc tcaaatggag ggtctggcgg 571981 ttcactgggc gatgcggcag atggcttggg caaaatcaat cagcagctgc agctcgtgag 572041 caaacagatt tcccaaaccg gcaataccgc acagaccgtg cagcagctta cggcaataag 572101 cggacagctt ggccagattc aaaccggcct tgaacaagcg aaccaacagc tctcaggcca 572161 gcaggcacaa gccggaacgc tgacagaaag cctgaaaaag ctgtccgaag gcgtgaaaag 572221 cgcaaatgag ggcctgacga aagtctctga cggtattaca gcttccagtg atatattaga 572281 ggacatgagc aaaagtccaa ctgtaagaga tactggcata ttcattcctg atcaagtaat 572341 gaaggacaaa gactttaaga agtcaattga ccagtattcc tttgcagacg gcaaaggtgt 572401 tcaattaagt gtcgttctgg attcaaatcc gtactcagaa caagctatta cgacaataaa 572461 ccaaatcaaa aaagctgtcg caaacgaagt tgacggcact cctttggaga atgcacagat 572521 cgtgtacggc ggggtcacga gtatgaatgc ggacttaaag gagctatcca caacggactt 572581 ctccagaaca atggtgatta tgattatagg cctgtttatc gtgttaacca ttttgttccg 572641 ctcaatgatc atgccgattt atatgatcgc gtcattgctg ctgacgtact atacgtcgat 572701 atccataaca gaattaattt ttgtaaacgg cttaggaaac gcgggtgtca gctgggcagt 572761 gccattcttc agctttgtca tcttgatcgc gttaggggta gattattcga tcttcttgct 572821 ggatcgattt aaggaagagg tgcaccttgg cattgagcaa ggtgtcgtca ggtcaatgag 572881 caaaatggga tctgtcatta ttacagctgc cattatattg gccggtacgt tcgcggcgat 572941 gatgccttca ggtgtcaata cactgatgca ggtggcaagt gttatcatca tcgggctctt 573001 gctttacggc cttgtcatac ttccgctctt catcccggca atcattgcga cctttggaga 573061 aggaaactgg tggccgttcg gcaggaagaa aggaaaagag taatcgagag aagagtgatg 573121 aatggtcatc actctttttt catgactaaa cgactaactt cagacgtgtt acccaaaaag 573181 atcagacgat caaacggcgg ctgtacttaa aaacaaagag cccggaaaac attcccgggc 573241 tctttgtttt atttccattc tgcaattgta tcaatcggca gacggtagga agcatagcct 573301 tcgtctgctg cttttccgat agaaagtagc ataaccggta cataacgttc tttatctaat 573361 ccgaaggttt ccgcgatgtt ttctttatcg tatccgccga tcgggtttgt atcgtagcca 573421 tgcgcgcgtg cagtcagcat cagctgcatg gaaacaagac ctccgtcaat caggatcgtt 573481 tcacggttga cctgtgccgg aagcttttca aaatgtgcgg tcagcgcggc gatttgtctg 573541 tctttgacct cctgcggcat gtaaccaagt tccacggctt ttgaatagat ttcttctaga 573601 tagtctgcgt tgttcatgtc tgcaaataca gcgatgacag cagatgatgt tgtgacttgt 573661 gtttggttaa agcttgcaag cggtgcgagc ttttcttttc cttccgggct gtcaatgaca 573721 agaaaacgcc atggctgcgc gttaacagaa gatggggcag ttgttgcttc ctctaagatc 573781 tctgtcattt cttctttgct gatttttact gccggatcat agttgcggat agaacggcgg 573841 cctttcataa tttccataaa atcgtttgtt ttgatcatgt tgatacactc ctcttaagct 573901 tcgatattat ttatattgtt tcgcatgcgc gccagcacat caatgagcag gcggcgttct 573961 tctgcgctta catttgcgag catttccttc atgaaacgct ccttttcctt cttagaagac 574021 tcaattcgct ctcttccttg gtctgttaac cgaacaaggg tgatgcggtt gtcctcaggc 574081 ttgcgccgcc ttgataccat gcctttggat tccagctgtt tcaggtgtct ggtaacggct 574141 gcgctatcga tatttacttt cttttgaagg tcgctttgac tgatctcatc tgcatgataa 574201 agcaatgtca gcaattccaa acgagattgg ctgatgcccg tgcatgcctc gaacttcacg 574261 ccaatcacct tgttcacgcc ttgcagctga tataaaatct cggcttcctc tgaacaaaat 574321 gacgccaaaa cccatccctt ctttcctgtc aaaactatta attgatatat caatgattga 574381 cacgtcaatt aatatacaac gattgatttc atcttgcaag ccatttgcac ttttgaacaa 574441 cctcccagcg cataaaattc gctaggctag aacttagcaa aaaaagctgg ccgcttcttc 574501 agatgatgct ggtcacgatg attccctgca tcattcccat ttataggtgt tcggaatatc 574561 actttgccgg cccgtgctca agcggctttc acaggctgaa agttatgata caatatacaa 574621 atgtttcaca gcttcaatcc atagttggag ctgacatcca ttatataagg gactaggttg 574681 aagggaaggt ttgataacat gctgcacaat ccaactggaa aagaacgctt ggcactagcg 574741 tttctgctcg gcatgcttgc tatattgggc ccgcttaata tagatatgta tttgccaagt 574801 tttcctgaaa tcgcgaaaga tttatcagca agtgcttcac ttgttcagtt aagtttaaca 574861 gcctgtctgg tcgggcttac gatcggccag ctgattgtcg ggccggtcag cgatgcgcag 574921 ggaagacgaa aaccgctatt aatctgtatt tttttatttg cgttatcttc tctgttttgt 574981 gcactgtcgc ccaatataac aactttagtg gctgcgcgtt ttttacaagg cttcactgct 575041 tctgcagggc ttgtgctgtc tcgcgcaatc gtccgcgatg tgtttaccgg aagagagctt 575101 tctaaatttt tctcgctgtt aatggtcatt accgcggtgg cgccaatggt tgcgcctatg 575161 acaggcggtg ccattttgct tttgccgttc gcaacgtggc atacaatttt tcacgtctta 575221 atgatcatcg gatttttact agttcttctg attgcattga ggttaaaaga aacgcttccg 575281 ctggaaaaac ggattccaag ctcaatcgga acatccgtca aaacgatggg cagcctgctg 575341 aaggatcgat cctttatggg gtacgcgtta actgtcggat ttattcacgg gggaagcttt 575401 gcatatgtgt ctggtacgcc ttttgtatac caggatatct acggggtgtc tccgcaggta 575461 tttagtattc tttttggcat taacgggctg gcgattatat cgggcagctt tatcatcgga 575521 cgctttggcg gaatcattca tgaaaaaagc ctgcttcgta tagcggtcat tacggctatg 575581 attgcgacgg ctgtgctatt aaccatgacc atgattcacg gtcctcttgc tacattagtc 575641 atatccattt tcatttacat gattacgatc ggcatggttc tgaccagcac gtttacccta 575701 gccatggaaa agcaggggca ccgcgccgga agtgcaagtg cgctgcttgg aatgcttccg 575761 ctgctcctcg gttcaatcgt gtcaccgctt gtaggcatta atgagacaac agccgttccg 575821 atgggagcca tcatgtttgt gacagctgtc atcggctcac tggcgttttt tggattaacg 575881 aaagaacgag tagggcagaa ttcataaaaa aacctgacat gacgtcaggt tttttgtttt 575941 atttagaata acaacagcag gcctgcaatc gccggagtca aaaagatggc tgatttcaaa 576001 accacctttg gcatgaggtt ggtgaatttc gcgcctacat aggccccgca cattgtcccg 576061 accagaactt tgacaagtaa aacgtaatca acaaaacctt ctgtaatata tccgatgcct 576121 ccacctacag ccagagggat gatcacaagc atcgtcgttc cgacagaatg gcgaatggac 576181 agattcagca taatcattaa accgatttga ataaaaggtg ccgacccgat gccgaatgtg 576241 ccggaaagaa cgccggctgc aattcctaag atgaccgctc tcgtatacgt tgaaagagtg 576301 ctttgattca cttgagcctt ctcttttaaa ataaataatc tgattaaaat gagaattgct 576361 gataaaaata acattccagc cgtcaaataa tgaagcaaat cagccggaat aaaagaagtc 576421 agcttggcgc cgaaaaatga gccaaccgca gcaaagcctc cgactattaa gccgattttc 576481 atttgaatgt taccctcgcg atagtggctg tatgcccctg ataagcttgt aaaagccatg 576541 ccggcaagcg aagtgcctaa agccgtatga atcgggatat ggaaaagaag cgttaaaagg 576601 gcaatgacaa agccggctcc accggcgcca ataaagccta aaataattcc tagaagaaac 576661 ataacaagaa taatgagcat attttttcct ccattgaaaa gatgtaaaaa tgtaatcgtg 576721 cgctattctg gcggaggtat ggtgtcctat tgacgaagaa aaacacgccg ttttttcagt 576781 tgccagtagt ccgtcgaccg tcgttcagca aacatatcgt acctcaaatt cagggatctg 576841 acaaggcagt ttgttgcttc ccattaccat ctgttatatg attttgatga agaaaagccc 576901 ttgaatatat tcaaaagagg tattatatat ggacgatttt aaattagata agccgactcc 576961 ctactacctg caattttata accagctaaa aaaaatgatc ttcaacggga cttttaagcc 577021 tggggaacgg ataaacgaaa cacagctggc gaaaagcttt ggcgtcagcc gctctccgat 577081 aagggaagcc atgcgattgc ttgagaaaga tggtttgtta aaagcggatg accgaaatgg 577141 gttttcgatc acgtcgttaa cggcaaaaga tgtagatgag atttataaaa tcagaattcc 577201 gctggagcag ctggcagtcg aattagtcat agacgaagcg gacgaagaag agctgaccat 577261 actcgaaaaa cagcttgaag aaacagagaa agcgattcac aacggcacgg aagatacaga 577321 aatcattcgt ttaaaccaaa aatttcatga gctgctggtt gatttcagcc ataacagaca 577381 tttgaaaaat ttgcttgagc atgtaaatga cctgattcat ttttgcagaa tccttaatta 577441 taccggcgac caccgcgcag aaacgatact gcgtgagcac cgcaggatat ttgaagaagt 577501 gaaaaagaaa aacaaagaag cagccaaaca acatgtgctg gctcatttca atcatgactg 577561 tgagcatttg aagcatgtgc ttgaagaagg taaagagaat tgatttgtat gatccggtac 577621 caagggagag cagaaccctt ggtatttttt tatgtattca ccacatatct aagaggcccc 577681 gttaataaga ttttatgatg gtttgactaa cgaataatgg gggttaaata tgtttatcca 577741 tatcgtcggg cctggtgatt ctttgttttc gataggcaga agatacggtg cttctgttga 577801 tcaaatacgg ggtgtgaatg gtttagatga aacgaatatc gtgccggggc aggctctgct 577861 tatccctctt tatgtatata cagtccagcc gagagatacg cttaccgcca ttgcagctaa 577921 agcgtttgtg ccattagagc gactgcgagc ggccaatccg ggcatcagcc caaatgcttt 577981 acaagcggga gcaaaaataa cgattccttc gatctcaaat tacattgcgg gaacgttaag 578041 tttttatgtg ctccgaaacc cagacctcga tcgggaatta atcaatgatt atgcgccata 578101 ctcgtcttcg atttcaattt tcgaatacca tattgcaccg aacggcgaca ttgcaaacca 578161 attgaatgat gcggccgcta ttgagacaac ttggcaaaga cgagtcacgc cgctggcaac 578221 aataacgaac cttacatcag gaggcttcag tacggagatt gttcaccaag tgctaaacaa 578281 tccgacagcg agaaccaatc tggtcaacaa catttatgac ttagtttcca caaggggata 578341 tggcggtgtc acaatcgatt ttgagcaggt gagcgccgcg gatcgcgatc ttttcactgg 578401 atttttacgc cagctgagag atcgacttca ggcgggaggg tatgtgctga cgatagctgt 578461 tcctgcaaaa acaagtgata atatcccatg gctgaggggc tacgattacg gggggatagg 578521 agcggttgtc aattatatgt ttatcatggc ttatgattgg catcatgcgg gaagtgagcc 578581 gggtcctgta gcgccgatta ctgaaataag gagaaccatt gagtttacga ttgcgcaggt 578641 gccgagcaga aaaatcatta tcggagtccc gctctacggg tacgactgga tcatcccgta 578701 ccagccgggc acagttgctt cagcgatttc aaatcaaaac gcaatcgaaa gagcgatgag 578761 gtaccaagcc ccgatacaat attcagccga atatcaatca ccgtttttcc ggtacagtga 578821 tcagcagggg cggacgcatg aggtatggtt tgaggatgtc agaagcatga gccggaagat 578881 gcagatcgtc cgtgaataca gattgcaggc tattggcgct tggcagttaa cgctgggctt 578941 tacgccgggc ccatggcttc tgcggaaatt ttttacgatc agaaaagtgt aaaaaaagac 579001 accagagctt gggtgtcttt tttttgatta agtccagagc agcagaatag ttcattcatt 579061 tgtaccttgc atgggttgtg ttcccatttt acgattagta gtagtctgat caaacaaaga 579121 gtcagaatac gatttgagag ggagttgtct acatgaagac agtattgatt ttgaattttc 579181 ctgcggaagg ccatgtgaat cctactttag gcattacgaa agcgttttcc gataagggat 579241 atgatgtcca ttatatatcc actgaaaaat ataaaaaacg attagaagca gcgggagcaa 579301 cggtccatct tcaccgggat ctgctgcgaa cgacacctat tcatgtcggt tcgcccaatg 579361 gcattcttga tttcgtgaaa atccatatca aaacgtcatt ggacatttta cagattgtca 579421 aagacttatc taagagcatt caatttgatt ttgtttatta tgataaattc ggcgcggggg 579481 aattggtgag ggattactta gatattccag gggtctcttc atcggcgtct ttcctgtttg 579541 gcgaggagca tctgaaaatc ctgccgctgc atccggagtc tggagcgccg cttgaattgg 579601 atcaagagtg cgaagacctt ttggcaaaaa tgaaagaaac gtacggtgtt gccccgaaaa 579661 acctggttca attcatgaac aataaagggg aattgaacgt agtgtataca agccgttatt 579721 ttcagccaga aagtgatcgt ttcggggatg aatgtctatt tatcgggccg agctttccaa 579781 agagagcgga aaaaacagat ttcccgattg aacagctaaa agatgagaag gtcatttata 579841 tttcaatggg gactgtactg gatcatacag aggatttctt caacctttgt attgatgcat 579901 tttcaggctt taacggaaaa gtcgtcatcg ctgccggaga aaaagcggac ctgaccaaat 579961 taaagcaggc gccggaaaac tttatcattg ctccgtatgt ccctcagctg gaagtgctgg 580021 agcaatcgga tgttttcatt acacacggcg gaatgaacag cgtaaacgaa ggcattcatt 580081 tcagcgtgcc actggttgtc atgcctcatg acaaggatca gccgatggtg gcgcagcgtc 580141 tctctgaact ccatgcaggc tatgtcatct ctaaagatga agtcaatgcc caaatattaa 580201 aacaggccgt agatgaggtt ttgcgcaacg atcagtatac ggcaggcatt aaaaaaatca 580261 atcaaagctt caaagaatgt atggacatgg aagaagtgat ggagcggatt gatgagttga 580321 ttcgccaaaa aaacaaataa gaaaaagaac tcccgtacct tgtacgggag ttcttgattt 580381 aaaacttgat tttgattttt tgagcatcac tgattttctt atggttatgg tcaaagacgt 580441 cacttgtcgt gatttcgatc cacttgatct cttttgtttt cttctcagca tccgcggcct 580501 tatcatgagc atggccgctt gatgcgttca caataaagcc gagatttccg gacttttcgg 580561 cgccgccttc caattcgccg tttaactctt caagataaat atctttgttc caatcaaagg 580621 tttcacccgt atttgttttc atcaatgcaa tcggcgcaac atttactttt tttgtagagg 580681 tgttcttgat atcaacgaaa accttaacga aatcaaactc ttcatcgtgt gttaactcat 580741 gaaagtaatc aatcatgctg tagtccgggc gcaagtggat cagcttcatt tcttttactg 580801 ttaactccac gtcgccaatt ttataggttt tgttcacttg tttgatatct tttaagacag 580861 cttttccttt atcatctgaa aacgtttggc cgaccttatg caatgtccgg tcatcagtta 580921 cctgggaatt aggctgataa tcatctgtgc tgtccttctg ggatgaagtg ctttgcggct 580981 cagcttttac tgttttctcc ccgcctgcat gctgtttttc agtactggcg tttgatgagc 581041 agcccgcaag catgatagca aaaacgagaa ttgaaagaat tcttctcatg atgattcctc 581101 cattaaaaag agatcccgtt acttcataca agcaacggga caccttgtat tcttttactt 581161 atcgttaatc ttaatgttgt attgtaaagc cttgaaaaca tttttggcga tttctgtatt 581221 gtcgatttgg ccggcaaatg tctcactaga cggaccgtat gcatagacgg gaacatcttc 581281 accggtatgt ccgcctgttg tccatccagt gtgagagcgt ttattaaaga tgttctcgat 581341 tgcgttatcg atatccagta cttccttcga ttttgccgct tcttcaacag attgaatttc 581401 ggcttttgtt aaagccaatt tcttttgatc gatatatgtt ttcaacgttt tttcaacatc 581461 cgcgccgtca gcgatctttt ctgccataaa gtctggtgtg cgctttgcgg ctttaatggg 581521 ttcactgaac cagttgtaga tgccgtccgc accgatggaa tatccgccgg ttgagtggtc 581581 agccgttgcg acaaccaatg tgtgcttgtc ttttttagcg aaatcaatag ccgccttata 581641 agcttgttcg aagtcttcca tctcgctcat ggcgccaacg atatcattgt catggcccgc 581701 ccagtcaatc tggctgcctt ccaccatgag gaagaatccg tctttatcct tgtttaattt 581761 tttaatggct gtgtttgtca tatctttaag tgatggaata tccttcgtac ggtcaatctt 581821 tttaggcagg ccgccgtcag cgaataggcc gagaacttgg ctgtctttgt ttttcagcat 581881 gtccttgcga tcatccacgt agctgtaccc cgcctttttg aattccttaa tcaaattacg 581941 gtccttacgg tcaaaattgc tctttcctcc gcctagaagg acatcaattt tgtgcttgcc 582001 gttgaccatc tcatcaaaat aatcatccgc aattgagttc atattttttc ggctgtggtc 582061 gtgtgaacca aaagaggccg gagtggcgtg tgtaatttct gaagtggcca caagtcctgt 582121 tgcttttcct ttttctttcg cagcttcaag caccgttttg gcttctgacc cgtcgttatc 582181 aacggctatg gcattattgt atgttttaat tcccgcagac atagccgttg ccgccgctgc 582241 agaatccgtt acattttgtt caggatcatc ggggtaagtt gtttgctggc cgacaagata 582301 ctgatcaaaa gccgtaggct ccacaacttt tgtcttttta ttatccttta agtatcgata 582361 agcagacgta taagacacac ccataccatc accaatcaga acaataacat ttttaatttc 582421 gtcttggttc ccctttttct tttcctgggc gctggcttca ggcacactgc cgctggctaa 582481 gctgctgaac gcaattgatg ataaaaccgc gataggcagt aatttcttcg ggaatttttt 582541 caactggata acctcctaaa tatagatgaa tctcaatgac aacccaatta tatttttaaa 582601 ctgttaagct agtattaatc gattttaaag attggattta caagaataat gaactggcac 582661 ccttaaataa tggttattct tttatgagaa gttttagaag gaaagagcga tagtactaaa 582721 gaaataaatt ggaggaatag atactggccg tggataggcg gactgaaatc tgctatagtc 582781 gcatagaagc aacccgctta catcttgaac aatttaaagt attacgttgg aaagaggtat 582841 tgtgtaagca catgtctgag cagttcatat ggagtggcat cattttattt taggagggaa 582901 caacatggac gttttttctg agtacttagc ggggattgct gacccgttcc accgagaaag 582961 aacggaagag gtgttaactt ggataaaaaa taaatatcca aatttacata cagaaataaa 583021 atggaatcag ccgatgttta cggatcacgg tacatttatt attggcttta gtgtttctaa 583081 aaagcattta gctgtcgctc ctgaaaaagt aacgatagcg cacgtagagg atgatattgt 583141 gaaggccgga tatgattaca ccgagcagct gatacgtatc ccttggaacg gtccagttga 583201 ttatacgcta cttgagaaaa tgattgagtt taatattctg gacaaggcgg actgctccac 583261 tttttggcgg aaatgaagaa aaaggcataa catatgagct gtataaaata tgttacgcct 583321 tttcatttgt ctatttttcg ttttgatcat ctattgctgc ttttcatcaa acaaggtctt 583381 ttcattgagc gtaagctgac tcgcagaata atgattacct tgtttccatt tcacttcaat 583441 cgtaatatca tggccttcaa gctcatgttc atctaaccgc tctaaaaaag aaacggactt 583501 ttcttttgcg cttccatcag aaaaagtgcc tccagcataa tcatgcatcg ggatttccgt 583561 gtcagaactc agcagaactt catcatcctt ttttacaatc agtgattcca gataagtgtt 583621 gtctatttca attgtatcac cgatccaata aagtttgccg ctgtattcat tcggtgcatc 583681 ttcatttttt gtgaaaacag cttcccaatt ctgatctttg ctttctccct gccaatttgg 583741 atactccaaa cgaacatgat gaatcaggtg ataggaaaaa aagatcaagc agaaagcgat 583801 taataggaat gccgtgaaaa tgagagggta tttataatga ctggacataa aagactccta 583861 ttcgtttaat caattacctt cgaaaataga atttcatccc gaatcaaaat gccgttttca 583921 gccacctcgg gaatctccgg cttgagtcgg cgcgcttttt caactgcgtt cggaaacact 583981 gcggcgaatt gatagcctct cttttgataa aacgctatcg catttacatt atcattcgtt 584041 gtgataagct ttattcgttg acaatgtgca tgtttagcct tctcttcaac ctgctgaagt 584101 aaagctgtgc cgattccttt attttcaatc atactatcta atgaaataat ttcacaatct 584161 ttcccatcta ttgtgtatgt aatacagcca atgatttcgc cgctttcatt tactgcggca 584221 aatccatcta attcatcaca ccgaaaaatg ccgctggaaa tcgccatctc gggtgtaccc 584281 caatgcttgg caaaaaaatc ggtcaacata tgtttcgcta tctcattgtt tgggatgatg 584341 atcatcataa cactcctcta ttgaaagatt gcatatgtac tatcaatata aacaatatat 584401 aacaaaaaaa atagatgttg aggtgacggc atggaaatca gcgatatcat ttacgggcag 584461 caccatatag acggagtgct ggaagagctt atcaaaagcg ctcctgtgca aagattaaaa 584521 ggaatctatc aaggcggagc aagcttttta gtcaatcgaa agtggaatgt gaccaggtat 584581 gagcactcca tcggcgtgat gctcctcatc aaaaagctcg gaggaacgat agaagaacag 584641 attgcgggtc tgctccacga cgtatcacac acagcttttt ctcatgtggt cgacgttgtc 584701 tttgaaaatc aagcagaaga ctatcatgaa aacatctttc aacaagtcat tgttcactct 584761 gaaatcccgg acattttaca aaaacacggc tatcatactg aagaactttt atctgacgat 584821 tcaaggtgga cattgctcga acagcccgca ccggagctgt gtgctgatcg gacagactat 584881 acgctgcgtg atatgtaccg atatggacac attaacctgc acgaagcgca aacctttttg 584941 gatcatctta ttgtgagaaa cggaaggatg tttcctgata gtattgaagc cgccgaatgg 585001 tttgtcagtg tgtactacaa ggaagtaatt gatttctttt tgaatcctgt gaatgtatat 585061 ggatatgaat atttagcgcg agcattgaag gcagcgctgc ggcatgatgt catatctgca 585121 gaggatctgc tgaaaacgga ccaagaggta ctgaacatcc tgcgtgcatc aaaaaatgaa 585181 gaagtcctga gcttgcttac atccattcat cccggcatac aagtaataga ggatgacatc 585241 cagtacgatt tccatcaaaa gaagaaaatg cgcctaatcg atccatccat ttttcttgat 585301 gacaaatgga tcaaatcctc aggtgtttct gaaaaggtga ggaaaatggg tgaggccgct 585361 tatcaaaaag caaaaaaagg tgtgtatata aaaatcttaa agcagtaatt gccgcctgac 585421 agcggctttt tttatgtttg gctttgcaaa caaaggggaa taggacaaac tgcgggaacg 585481 ctttatgaga atatcagcgt atttacatac cgttcggggg tatagtatta tcgagagggc 585541 atgttttcat tgtctgcggg caaaagttac aggaaaaaaa tgaagcaaag gagaatgaac 585601 atgaaaatct ctaaatatgc actgggaatt ctgatgttat ctctagtttt tgttttatca 585661 gcatgcggca ataacaacag tacgaaagaa agcacacatg acaatcattc agactcctca 585721 acacatgaag agatggacca ttccggatca gctgacgttc cagagggatt acaggaatct 585781 aaaaatccga aatacaaagt aggcagccaa gtaatcatca atacttctca tatgaaaggc 585841 atgaaaggtg ctgaagctac ggtaacaggc gcctatgata caacggcgta tgttgtttct 585901 tatactccga ctaatggggg acagcgtgtg gatcatcaca aatgggtgat ccaagaagaa 585961 atcaaagatg ccggagataa aacgttacaa cccggagatc aggtgatttt agaggcttct 586021 catatgaaag gcatgaaagg agcaacagcc gagatcgatt ccgcggaaaa aacaactgta 586081 tacatggttg actacacatc gacaacgagc ggcgaaaaag tgaaaaacca caaatgggtc 586141 acagaagatg agctttcagc taaataataa aaaatcctcc ttttacaagg aggatttttt 586201 tgctgtttga acaggtcttg ttaaagaaat gaaagcaaac aggacagcga tgatcacaat 586261 cgatccgccg caccatgccg ttgacaccac agtacccgtc tgatccaaaa caacaccgcc 586321 aatggctgag ccaagggcaa ttccgacttg gagggccgat gtgttaaagc tttgctgaat 586381 gtcagacgaa tcaggtgcaa tttcaattaa atagctttgc tgagccgggg cgaggctcca 586441 gctcagaaga ccccaaatca ccatgacagg caaaaagaaa atcatagacg atgtagacag 586501 cggcagtaag aacataatga tggcaaagga accggtcacc agcaaaatgc tcttaaagga 586561 accaagccgg tcagatagcg ctcctccgaa agggcctccg catacagcag atatcccgaa 586621 aaggaaataa caaatgctga cccagaaaga gctcaggtga agagtctctt ctaaaaacgg 586681 cgcaaagtaa gcgtaaagcg tgtagtggcc agctaatgta aacatcgtga cgaggtgtga 586741 actcgcgatt ttcagattac cgatcgtctt gagttgttcc cggaaaggaa tcattttctc 586801 cgccggtatt ctttcaaaga agattgaaat aatcagcatg gagatcagtg ccaacaggcc 586861 gatgccaagg aacaaaatcc gccacccgaa ggaatcgctg attaagattc cgagcggcac 586921 gcctaatgcg atagcagagc tgaatcccat aaaaataatt ccgattgcgc gggctctgta 586981 ttcaggcgct acaattttcg gggcaattgt taaagaaagc acaacaatca gccctgtact 587041 cattgctgcc aataccctag ataccatcag tgttgcgaaa ttagggctga aataggcgac 587101 aagattgcta aggaagaaaa caaataaagc aattagatat aagcgcttcc gctcaatctt 587161 cgcagtcaat gccaaaagca gcggcccaga tactgcatat cccagcgcaa acacactgat 587221 cagctgtccg gctgaaacaa tggaaatgtc taaatcattt gcgatctgag gaagaattcc 587281 ccccacaatt aactcaacca atccgactgc aatcgtagaa gctgcaagca ggaaaacttt 587341 gaaattcata acaaactcct ttacttaaat gttttgataa ataaaaaaaa tcctgattac 587401 aaaaaatgtc ataaacaaat tttgtaatca ggattttacg gttcctggta gacaccctca 587461 aaccatatta ttgaggttat acaagtgata atagctattt aattgattcg tttccgttga 587521 tgagtgtacc acattatgaa tgaatcttcc atagaaaaat ttataaaacg gtgaaccgga 587581 aaaaaatatg attatattta ttttataaaa gtatagacat ttaaaattaa atgactataa 587641 taatcaatgt aagcgtttta ataacagggg ggatagcagt tgaaaaaaat attactcgcg 587701 tgcagttcag gaatgtctac cagtttattg gtgacaaaaa tgaaggaata cgcacagtct 587761 atcggtgagg aagcggagat ttgggctgtt ggccaggata aagcaaaaga agacatgaga 587821 aaagcggatg ccgttttgat cggtccgcaa atgagctttc tgaaaagcga gctccaaaaa 587881 gaagcagatc aatacaacat tcaagttgaa gtcattgaca tgatggccta cggaatggca 587941 gatgggaaaa aagcgtatga gcaggcattg tccttaatgg tgaatcaata atggaacaga 588001 tgaaaatcac gaatttaaca gacgagcaaa tcagttttca gctaatcctg cacagcggaa 588061 atgcccgcag ctgcatcata caatcactgc gcgcctataa agaagggaaa aaggacgagg 588121 ctgatgccct cattgccaag gcggagcagg atttatccgc ggcccatgac attcactttc 588181 aaatgataca gaaggaatcc ggcggagaag caacagcttt ttcattgctg cttatgcatg 588241 cagaggatca tctgatgtca acattatcca tgaaagaatt agtgaaagag atgcttgatc 588301 tctttaaaac caagaatata taaaaaatcg gggtggatag ggtgttcgag aaaatcagcc 588361 aattccttgt tccaattgca gggaggttaa acaataaccg ctatttgcaa gtgttgcgtg 588421 atgcatttat gctggctttc ccgctgacga tattcgggtc catttttgtc gtgttaacga 588481 atttgccgtt tctaaacaaa atcatgaacg cctcaatgct tacgtcgttt cagtctcatt 588541 tcggcattgc ctccacggcg acaatgggca ttatgtctgt ctttgttgtg ttcgggatag 588601 gctattacct gtcgaaaagc tatcaggtcg aagctgtatt tggcggagcg atcgctttgg 588661 tttccttttt gctcttaacg ccatttatca ttcagccgga aacaggtgat gccattacag 588721 gggttatccc ggtcgatcgt ctcggtgcaa aagggatgtt tcttgggatg attacggcat 588781 ttctttctgg cgaaatttac agaagaatcg ttcaaaaaaa cctgacaatc aaaatgccag 588841 ccggcgttcc gcctgctgta gcaaaatcat tcgccgcact tattccggct tttatcacat 588901 tgactgtatt tttgctgatt aacgtaatgg tgactctgtt ttttaaaaca aatatgcacg 588961 acgtcattta tcatgcgatt caggctccgc ttgtcggact tggaagcggt atcattccaa 589021 cactgattgc cgtgtttttc attcaaattc tttggttttt cggactgcat ggacagatca 589081 ttatcaactc cgtgatggac ccgatttgga atacactgca ggtagaaaac ctttctgctt 589141 acacggcggg aaaagaaatc cctcatatta tttcaaaacc gtttatggag atttatacag 589201 tagggatggg cggaacaggg atgacgcttg cgattgtgtt taccattctc atattcatga 589261 aaagcaggca gatgaagcaa gtatcaaaac ttggcctcgc tcccggtatt tttaacgtaa 589321 acgaaccgat tatctttggg cttccgattg tcatgaatcc gatcattatt gtgccttggg 589381 tgctggcacc gatggttgtt acgctcgtca cctatctggc tatgtcagcc gggctcgttc 589441 cgcctccaac tggtgtgaca gtgccgtgga cggttccatt attcattaat ggcatcatgg 589501 cgacgaactc aatcatgggg ggcgtgatgc agcttatcaa tctgctgatt gtcttcgtga 589561 tctggtttcc gttcctaaaa gcaatggata aattaaatct ggcaaaagaa aaagaacagg 589621 ctgtgcagga gacagctgct cagcaaaatg ataacagcat aaaaatgtga cataagggga 589681 gagagacttg gcacatacag aacaatatcg ttttccaaag gatttttggt ggggatcatc 589741 cgcttcagca acacaaatgg agggtgccgc cgacagagac ggaaaaggcc agaatatatg 589801 ggattattgg tttgaaaaag aaccgcatcg tttttttgat catgtcggac ccgcagacac 589861 atcccaattt tacgacaact ataaagaaga tatcaggctg atgaaggaac ttggccacaa 589921 ctcgttccgg atgtcgattt cctggtcacg tttaatacca aacggaacgg gcgagatcaa 589981 cgataaagcc gcagatttct ataacaatgt cattgatgag ctgatcgcta acggaattga 590041 accttttgtc aatttgtttc atttcgatat gccgatggcg cttcaaaaaa tcggcggctg 590101 ggtcaacaga gagacggttg acgcgtatga aaactatgca agaacttgct tccgtttgtt 590161 tggcggccgg gtgaaaaaat ggttcacgca taatgaacca atcgttcccg tagaaggcgg 590221 atacctatat gattttcatt atccaaacaa ggtcgatttt aaagaggccg tccaggttgg 590281 atttcatacg atgctatcaa gtgcccgcgc cattcaggct tacagggaga tgaagcagga 590341 cggaaaaatc ggcatcatct taaatttgac cccttcatac ccgagaagca gccatccggc 590401 ggatgtgaaa gccggggaaa tcgcagacgc gttttttaac agatcttttt tagacccatc 590461 tgtcaaaggc gaatttccca aagagctggt tgacattttg aagcatgaag gctttatgcc 590521 tgattacaac gctgaagatc tcgacatcat caaaaagaac acggttgacc tgttgggagt 590581 gaattattac cagccgagac gtgtgaaagc gaaagaacat cttccgaatc ccgacgctcc 590641 ttttttgccg gacaggtatt ttgatcccta cgtcatgccg ggccgcaaaa tgaatccgca 590701 tcgcggctgg gagatctatg aaaaaggcgt ttatgatatt ttgatcaatt taaaagaaaa 590761 ctacggcaac atcgagtgtt ttatctctga aaacggtatg ggggttgaag gtgaagagcg 590821 attcagggat gaacaaggca tcattcagga tgattaccgg attgaattta taaaagagca 590881 cctcaaatgg attcaccgcg ccatacagga aggctcgaac gtaaaaggct atcacttatg 590941 gacgttcatg gacaactggt cttggacaaa tgcctataaa aaccgatacg gatttgtatc 591001 agtcaatctt gagaaagacg gagaaagaac cgtcaaaaag agcggaaaat ggttcaaaga 591061 ggttgctgag catagcggtt tctagatttt cctaaaggtc aagatcttcc ggcaatcatc 591121 ataacgaata gagatgacga aaatccgcaa cattgatgaa atagggaaaa gaacttatga 591181 tatccgtaaa agcttatgtg atatcaaaca gctgccggag gataccaatg aataaatacg 591241 aaatcattgc aaatgaaatg agaaatagaa ttaaaaataa cgtatatccg atcgatcagc 591301 ccattcctga tgaagtatct cttgcaaaag aatttaactc aagccgcatg acgatgaaga 591361 gagccttgga taatttagtt gccgagggtc tgctgtttag aaaacgaggc catggcacgt 591421 ttattattca atctgcaata caggatgacc atgtccatgt agtcagcaat gagattctcg 591481 gattgaccaa cttgctgaaa gataaaaaaa tcaaaagcaa ggtcattcag tttgaagtgc 591541 aatttcccac tgaggaagtg gccgcccatt tgtctattga tcagaaaaca ccggtttatt 591601 atgtcgttcg gctgcgaatt gtagaaggtg aaccctatgt attagaaaaa acatatatgc 591661 cgactcattt aataccgggc attaatgacg atgtccttca tgattcgatc tacaatcata 591721 ttacaaatgt gctgcagctc aaaatcgccg gaacgcatcg gaaaatcaga gcctgcaaat 591781 ctgatcatat tgaccagcag catctgggct gtaaacagga tgatccaatt cttgaagtgg 591841 aacatgtggg cttcttagat accgggattc catttgaata ttccttttca cgtcatcggc 591901 atgacaagtt tgttgtgact tctgtaaaca tacggcgctg attgcggaga caacaaggag 591961 gccatctgca tgcttggcgg tattgaagca ggcggcacaa agtttgtttg tgctgtcggt 592021 agagaagatg gaacgatcat tgacaggata gaattcccca caaagatgcc ggatgaaacg 592081 atagagaaag taattcaata ttttagccaa ttttcattac aggcaatcgg catcggctcc 592141 tttggtcccg ttgataacga taaaaccagt caaacatacg gtaccattac ggccacgccg 592201 aaagcgggct ggagacacta tccctttttg caaaccgtta agaacgaaat gaagatccca 592261 gtcggattta gtacagatgt caacgctgcg gcgctgggtg aattcctttt cggtgaagcg 592321 aagggtcttg acagctgcct gtatataacg attggcactg gcatcggagc gggggctatt 592381 gtagagggga ggctccttca ggggctgtca cacccagaga tgggccatat ttatatccgg 592441 aggcacccgg atgacgtata ccaagggaag tgcccttatc atggagattg ctttgaaggc 592501 ttagcttcag gccccgctat cgaagcccgc tgggggaaaa aagccgcgga tttatcagat 592561 atagcacaag tctgggaact ggaagggtac tatattgccc aagcactggc tcagtatatt 592621 ttgatccttg cacctaaaaa aatcattctt ggcggcggcg tcatgcaaca gaaacaagtg 592681 ttttcttata tctatcaata tgtaccaaaa atcatgaaca gctacttaga tttttctgaa 592741 ttatcagatg atataagtga ttatattgta cctccacgtt taggcagtaa cgccggaatc 592801 atcggcacgc tagttttagc gcatcaggcc ttacaagcag aggcagcatc cggggaggtg 592861 cgatcatgac gcatccatta tttttagagc ctgtctttaa agaaagacta tggggaggga 592921 cgaagcttcg tgacgctttt ggctacgcaa taccctcaca aaaaacaggt gagtgctggg 592981 ccgtttctgc acatgcccat ggctcgtcgt ctgtaaaaaa tggcccgctg gcaggaaaga 593041 cacttgatca agtatggaaa gatcatccag agatattcgg gtttccggat ggtaaggtgt 593101 ttccgctgct ggtaaagctg ctggacgcca atatggatct ctccgtgcaa gtccatcctg 593161 atgatgatta tgcaaaactg cacgaaaatg gcgaccttgg taaaacggag tgctggtata 593221 tcattgattg caaagatgac gccgaactaa ttttgggaca tcatgcaagc acaaaggaag 593281 agttcaaaca acgaatagaa agcggtgatt ggaacgggct gctgaggcga atcaaaatca 593341 agccaggaga tttcttttat gtgccaagcg gtacactcca tgctttatgt aagggaaccc 593401 ttgtccttga aatccagcaa aactctgata caacatatcg cgtatacgat tatgaccgct 593461 gtaatgacca gggccaaaaa agaactcttc atatagaaaa agccatggaa gtcataacga 593521 taccgcatat cgataaagtg catacaccgg aagtaaaaga agttggtaac gctgagatca 593581 ttgtttatgt gcaatcagat tatttctcag tgtacaaatg gaagattagc ggccgagctg 593641 cttttccttc atatcaaacc tatttgctgg ggagtgttct gagcggatca ggacgaatca 593701 taaataatgg tattcagtat gaatgcaatg caggctcaca ctttattctg cctgcgcatt 593761 ttggagaatt tacaatagaa ggaacatgtg aattcatgat atctcatcct taatgaatgg 593821 gggagttgca tttgtttaag aaacatacga tctctttgct cattatattt ttacttgcgt 593881 ctgctgtttt agcaaaacca attgaagcgc atactgtgtc gcctgtgaat cctaatgccc 593941 agcagacaac aaaaacagtg atgaactggc ttgcgcacct gccgaaccga acggaaaaca 594001 gagtcctttc cggagcgttc ggaggttaca gccatgacac attttctatg gctgaggctg 594061 atagaatccg aagcgccacc gggcaatcgc ctgctattta tggctgcgat tatgccagag 594121 gatggcttga aacagcaaat attgaagatt caatagatgt aagctgcaac ggcgatttaa 594181 tgtcgtattg gaaaaatggc ggaattccgc aaatcagttt gcacctggcg aaccctgctt 594241 ttcagtcagg gcattttaaa acaccgatta caaatgatca gtataaaaaa atactagatt 594301 cttcaacagt agaaggaaag cggctaaatg ccatgctcag caaaattgct gacggacttc 594361 aagagttgga gaaccaaggt gtgcctgttc tgttcaggcc gctgcatgaa atgaacggcg 594421 aatggttttg gtggggactc acatcatata accaaaagga taatgaaaga atctctctat 594481 ataaacagct ctacaagaaa atctatcatt atatgaccga cacaagagga cttgatcatt 594541 tgatttgggt ttactctccc gacgccaacc gagattttaa aactgatttt tacccgggcg 594601 cgtcttacgt ggatattgtc ggattagatg cgtattttca agatgcctac tcgatcaatg 594661 gatacgatca gctaacagcg cttaataaac catttgcttt tacagaagtc ggcccgcaaa 594721 cagcaaacgg cagcttcgat tacagcctgt tcatcaatgc aataaaacaa aaatatccta 594781 aaaccattta ctttctggca tggaatgatg aatggagcgc agcagtaaac aagggtgctt 594841 cagctttata tcatgacagc tggacactca acaagggaga aatatggaat ggtgattctt 594901 taacgccaat cgttgagtga atccgtaatg tcacaattaa gaaggtgctc aagaagtttc 594961 ttgagcacct tcccactgga ttaagcattc atatcgccta acccaggact gtgttcattt 595021 ggtatttcag gaagcactgg tacgggaaac cctgccggag gatctattac ttgtaactct 595081 ccgccatttc ggcttggaga tttcccttga tagatttcac tgattctcgt ttcatccaac 595141 ctaaagttaa aatgtgtatt atggtagcct aattcgacat actttctgca ctcaggatat 595201 ttattaatgt cataattcgg cacagggagc agcttcgccc attcaacgcc caatgtctcg 595261 agcgctttcg cgaatgcatt ctggtgagca ttgtcgcgta caatcagaaa agcaagtgtt 595321 tcgcggaacg tctgattaga gctcatttca taaattcttg ttttttgcag cacacctgtc 595381 gactcaagaa gcaggttatc cagcaggtca gtaattaagt ttccgtggtt atacacccac 595441 gacccgttcc acggattgcc ccctgcatca acaggaaggg aactttgcgc tccaataata 595501 taatgatgag gattagcatg tttaaccgct tcatcaagtg gcgcttgatc tgtaccttga 595561 ctgccgacac cttcaccgcc tgattcatct aataaagcat tgattgtgtt ttgaaccagt 595621 tcaacgtggg caatctcctc taaaaaaatg ccgcgaagca gatcgcggta ctgtttctgc 595681 tttcctctga aattagagct ttggaaaaaa actgcatcat tgtacgcatt tctccgtaat 595741 gaccgcctaa tatctcctgc aggaccttag cagctgccgg gtctggcttg tccggtttaa 595801 tgatattaat cagttcctct ttgtagtaat acataacacg cctcatttct tcttaagaga 595861 ttttcttata ttatttgtaa gatgagataa aatatataca tgataagcat gggaaggcgt 595921 gaaagaagaa aataaaaaaa tacaggaaaa gtgttgacca aataaaacag gcatggtata 595981 ttattaaacg tcgctgatga acagcgtgaa acaaaacaga aaaacaaaaa agttttccta 596041 aggtgtttac aagattttaa aaatgtgtat aataagaaaa gtcgaattga aaaagattcg 596101 aaaaaacatt aaaaaacttc ttgacttcaa catcaaatga tagtatgata gttaagtcgc 596161 tcaataagcg cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg 596221 gttcgactcc tctcgggcgc gccatataag ataccacgcg ggtgtagttt agtggtaaaa 596281 cctcagcctt ccaagctgat gtcgtgagtt cgattctcat cacccgctcc attattgaat 596341 gatctttgaa aactaaacaa gacaaaacgt acctgttaat tcagtttttg aaaatcgcac 596401 agcgatgtgc gtagtcagtc aaactagggc ctgcacgatg caggtcacac aggtgtcacc 596461 gcgggatgcg gtggacttaa cctgtgatcc atttatcgga gagtttgatc ctggctcagg 596521 acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg aacagatggg agcttgctcc 596581 ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa gactgggata 596641 actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt caaacataaa 596701 aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt tggtgaggta 596761 atggctcacc aaggcaacga tgcgtagccg acctgagagg gtgatcggcc acactgggac 596821 tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc aatggacgaa 596881 agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa gctctgttgt 596941 tagggaagaa caagtaccgt tcgaataggg cggtaccttg acggtaccta accagaaagc 597001 cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt tgtccggaat 597061 tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc ccccggctca 597121 accggggagg gtcattggaa actgggaaac ttgagtgcag aagaggagag tggaattcca 597181 cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg cgactctctg 597241 gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag ataccctggt 597301 agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca 597361 gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac tcaaaggaat 597421 tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc 597481 ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt cgggggcaga 597541 gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc 597601 aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta aggtgactgc 597661 cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg 597721 gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg ttaagccaat 597781 cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg aagctggaat 597841 cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt gtacacaccg 597901 cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt ttaggagcca 597961 gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag 598021 gtgcggctgg atcacctcct ttctaaggat attatacgga atataagacc ttgggtctta 598081 taaacagaac gttccctgtc ttgtttagtt ttgaaggatc attccttcga aacgtgttct 598141 ttgaaaacta gataacagta gacatcacat tcaattagta atacaagata tcacatagtg 598201 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 598261 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 598321 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 598381 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 598441 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 598501 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 598561 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 598621 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 598681 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 598741 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 598801 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat cccgtgcaag 598861 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 598921 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 598981 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 599041 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 599101 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 599161 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 599221 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 599281 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 599341 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 599401 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 599461 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 599521 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 599581 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 599641 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 599701 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 599761 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 599821 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 599881 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 599941 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 600001 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 600061 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 600121 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 600181 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 600241 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 600301 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 600361 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 600421 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 600481 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 600541 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 600601 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 600661 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 600721 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 600781 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 600841 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 600901 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 600961 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 601021 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 601081 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 601141 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 601201 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 601261 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag cattactttt 601321 atcatcgcgg ggtggagcag ttcggtagct cgtcgggctc ataacccgaa ggtcgcaggt 601381 tcaaatcctg cccccgcaac caaatatatg gttaaataag gagtgcccta agggtgcaac 601441 caaaataatc ctatacaaat atggtccggt agttcagttg gttagaatgc ctgcctgtca 601501 cgcaggaggt cgcgggttcg agtcccgtcc ggaccgccat taatgtaaac gaaacgatca 601561 tgttttcgtt ttttttgtgt tttcttttac tgtatcttct gcttggtgtc atagccaagc 601621 tttctttata tcgggaacat cttggatatt ccagcaaaat tcgataaact aggaagagca 601681 caaataggca taagcagggt tgaaaggagg ttttggttca tggatgaatt tgatttgata 601741 catagcatta ctccgcggac cattcaccat tcttccgttg atgtaggaat aggtgatgat 601801 gcagcgctct acactgcgaa acacggcgtt caggaaattg tttgtgttga tactatggta 601861 gaagacgtgc acttcaaatt acactattcc tcacctgaag atatcgggta caaggcgtta 601921 gccgttaata taagtgatat tgccgcgatg ggaggcattc ctaagtttta tctggtatca 601981 cttgcggtac cttcaaaatg gactgaatct gaaatcaagg cgatgtatga aggaatgaat 602041 gaactggcga aactatatca tatggatctg attggcggcg atacagtttc taccgctgac 602101 aaattagtcg ttacagtcac tgtaatcggt gaaattgaaa agggacaggc ctgtttgcgc 602161 agcttggcaa aaccgaatga tattgtgttt gtaaccggtg aaatcggttc ttctgcagca 602221 gggctttctt tattgctgga agagactaat cctcaaaact catctgtgga aacggattac 602281 tttatccaca ggcataaacg gcctgagcca agagtaagcg tcggcagatt atgctcgatt 602341 tttaaacggg cagctttaaa tgatgttagt gacggattgg ctagtgaact gaacgagatt 602401 gcagaagcca gctgtgtttc aattgaaatt gttgaaagca tgcttccaat tcattctgat 602461 ttgcctaagc ttcatcctaa ctggaaagaa tgggctttgt ttggcggtga ggattttgag 602521 ctgacaggga cggtttcaaa tgaggagtgg gaagtgttga agcaggagtg cgcagcgctt 602581 catcttccca ttacaaagat tggctatgtc agggaaaaaa caaaatctaa agtgatccta 602641 aaaacagatc aaacatcaat gatcttagag aaaaagggat ataatcattt taaataagac 602701 gggtgactcg tgtgaagcaa ttaaaatgga gaactgtaaa tccagaagaa acaaaagcaa 602761 ttgccaagct gacggcagcg tttgctaaac cgggagacgt cctgacatta gagggcgatt 602821 taggtgcagg aaaaacgact tttacgaaag gttttgcaga agggctggga attacacgta 602881 ttgtaaacag tccgactttt acaattataa aagaatataa cgatggcgta cttcctcttt 602941 atcacatgga tgtgtataga atggaagatg aaagtgaaga tttgggactt gatgaatatt 603001 ttcacggaca aggtgtctgt ctcgttgaat gggctcattt aattgaagaa cagctgccac 603061 aggagcgact gcaaattgtc atcaaaagag ctggtgatga tgagcgggaa attaccttta 603121 ctgctgtcgg gaatcggtat gaaatgcttt gtgaggagtt aagtagacat gacaatatta 603181 gcaattgata catcaaatta tacattgggc attgcgctgc ttcgagaaga cactgttata 603241 gcagaataca ttacatattt gaaaaagaac cactctgtaa gagcgatgcc tgctgttcat 603301 tcattgctga atgattgtga tatggcaccg caggaccttt ctaaaattgt cgttgcaaaa 603361 ggccctggtt catacacagg agtaagaata ggtgtgacgt tggccaaaac acttgcctgg 603421 tctttagaca ttccaataag tgctgtatca agtcttgaga cgcttgcggc aaatggccgg 603481 cattttgacg gtctgatcag cccaatcttt gatgctagac ggggacaggt gtacacaggt 603541 ctgtatcaat ataaaaatgg gcttttagag caagttgttc cagatcaaaa tgtgatgctg 603601 gcagattggc tggagatgct aaaagaaaag gaccgccctg ttttgttttt aggccatgat 603661 acttctcttc acaagcagat gatcgaggat gtgcttggaa caaaaggatt cattggaact 603721 gccgcccagc ataacccgcg cccttcagaa ttggcttttc tcgggaagga aaaggaagca 603781 gctgatgttc atgggcttgt cccggattac ttgcggctgg cagaagctga agcgaaatgg 603841 attgaaagtc aaaagtaggg tgataggatg aaaacaaaag cagcggtcag aaatatgcgg 603901 cttgaagata tagatcacgt atacgaaatc gaagcatcct cctttacgtc tccttggacg 603961 aaggattcgt tttatcatga gctgctggaa aatccgtatg ctcattatct cgtgattgaa 604021 aaggacggcc atcttgctgg gtattgcggg atttggattg tgatggacga tgcccagatt 604081 acaaatatag cgataaaacc agagtatcgc ggccagtctt taggagaaac gctttttcgc 604141 tcagctgttg aactgtgcaa agaaaaagac gcaaggcggc tttcgcttga agtgagggtt 604201 tcgaatcatc ctgctcaagg cttatataag aaattcggga tgcagcccgg cggaataaga 604261 aagaactatt atactgataa cggggaagat gcgttaatta tgtgggtgac gataaatgag 604321 tgagcaaaaa gacatgtacg tattaggaat tgaaacaagc tgtgatgaga ctgctgcagc 604381 tattgtgaaa aacgggaaag agatcatttc aaacgtagta gcctctcaaa ttgaaagcca 604441 taagcgcttc ggaggcgttg ttccggaaat tgcttcaaga catcatgttg aacaaatcac 604501 tttggttata gaagaggcgt ttcgcaaagc tggcatgacg tatagtgata ttgatgcgat 604561 tgcagtaaca gaaggtccgg gactggtggg agcgcttctt atcggagtga atgccgctaa 604621 agcattgagc tttgcatata acattccgtt agtaggcgtt catcatatag ccggtcatat 604681 atacgcgaac cgtcttgtag aagacatcgt gttcccggca ctggcattgg tcgtttcagg 604741 aggccataca gaactggttt atatgaagga acatggatca tttgaagtca ttggggaaac 604801 ccttgatgat gcggcaggag aagcctacga caaagtggcg cggacgatgg gattgccata 604861 tccgggtgga ccgcaaattg acaagctagc tgaaaaaggg aatgacaata ttccgcttcc 604921 tcgcgcatgg cttgaagaag gctcttacaa cttcagcttt agcggattga agtctgcggt 604981 gatcaatacg cttcataatg catcccaaaa agggcaagag attgctccgg aagatttgtc 605041 tgccagtttc caaaatagtg tgatcgatgt cttggtaacc aaaacggcgc gcgcggcaaa 605101 ggaatatgat gtcaaacagg tccttttagc cggaggagta gctgcaaaca gaggcctcag 605161 agctgcatta gaaaaggaat ttgcccagca tgaagggatt acgcttgtca ttcctccatt 605221 agctttatgc acggataatg ctgcgatgat tgctgctgct ggtacaattg cttttgaaaa 605281 aggaattcgc ggtgcatatg atatgaatgg ccagcccggc cttgaattga cttcttatca 605341 aagtctcacg agataatagc gtgagacttt ttatctgttt gttattaaca gacaattcac 605401 aatttatcca catatctgtg agtaattata gagatattga tggataaagg gctgaggtca 605461 ctgttaataa agtggataaa ttcagaatat tttgtggata gtgtgtataa agcgcttact 605521 ttgtttattt attaggggat gttctgtgga taaaaagcac ctctaaaaag aggtgcttga 605581 cttttttaat cttcttctgt ggatagttct tcccattcgg acaaaagaga ttccagctcc 605641 tgattaagct tctcattgtc tgcatggata gcttgtactt tttcatgatc ctgatagact 605701 tcagggtcac atagcaattc atcattgcgg ctgatgttct cctcaatggt ttgaacggtg 605761 gtttcaattt cttcaatccg acggagtcgt tggcgctctt tctttttcca ttctttttct 605821 tcctcgtagg aacgtttgga gtcagacttc actgtagctg gcgttttatc agtttcctct 605881 tgctgattca ttttctccaa ttcaagctgc tctgtttttt tctctgtata ataatcgtaa 605941 tctcccagat actcctctat atggcttgaa gaaagctcca atactcttgt ggcgattctg 606001 ttaataaaat atctgtcatg tgagacaaat aacagtgtgc ctggataatc aatcagcgcg 606061 ttttcgagaa cttctttgct gtctaaatcc agatggttcg tcggttcatc aaggatgaga 606121 aagttggctt tttgaagcat cagcttagct agagccaatc ttgctttttc gcctccgctc 606181 agtgaatgaa ctggtttcag cacatcatct ccggagaata agaaatttcc gagacacgtt 606241 ctgatttctt tttctgggag cccggggtac tcgtcccaca gctcatcaag gacacgttta 606301 gaggaagtca actcagcctg ttcctggtca taatagccga cactgacatt tgagccgtaa 606361 gaaattgttc cctgatctgg ttttagggtg tctattaatg ttttcagcaa tgtcgattta 606421 cctattccgt tagggccgac aagcgcagcg ctttctcctc ttgtgagcat gaatgacact 606481 tctgttaaaa gcggcggctg gttttcatag ctgattgtga gatcctgaac acgaaggact 606541 tcatttccgc tctgttttgt aatatcaaaa tgaaagtttg cggatttttc atcgccaagc 606601 ggttttgaca tgacatccat tcgctcaagc tgctttctgc ggctttgcgc ccttttggtg 606661 gtagaggctc tcgccagatt tcgatctacg aagtcctgca gctttgcaat ctcgtcctgc 606721 tgcttttcat acattttcag atctttttca tactgcgcgg ctttttggtc gagataagcg 606781 ctgtagttgc cgtgatactt tttgctttct gctcttgata cctcgtatac ctggtttact 606841 actttgtcca aaaagtagcg gtcatgcgaa acgatgagaa tggcgcctga atagccttgt 606901 aaataatgct caagccaggt aagcgtatca atatccagat ggtttgtcgg ctcatcaaga 606961 atgagcaaat caggctgtgt taatagaagc ttacctaaag ccagtcttgt tttctggcct 607021 ccgctgaggc tttgaacctg tgtagaatcg tcaaaatggc tgaagccgag accatgcagc 607081 acagatctaa catccgcttc atattgataa ccgcctttat ctttgaattc ctgctgaaga 607141 cggtcgtagg ttttcatgat gctttctaat tcacccgggt cagctgccgc cattttttct 607201 tccatagccc gcatttcctt ttccattgct tttaagtggt caaaaacagt cagcagctct 607261 tcttttatgg taagcttaga atccaagcca gtatgctggg cgagatatcc cattgtaata 607321 tctttcggtt taataatttc gcccttttca tacgaaagct ggcctgcgat aattttaagg 607381 agcgtggatt ttccggcgcc atttcttcct acaatggcga tgcgatcacg atttctgact 607441 tccagcttta tattgtttaa aatagtatca gcaccaaatg atttggacag ctgattaact 607501 tgtaagatca tcatattatt tcacctctgc tataataagt taagtgtagc ttatgaacca 607561 gaagtcagca aacaatacat tggccatata agacatagag aagaaaatag tgtatgatct 607621 gtttaaggag cgttttaata tgaatggatt ttctcatttt aatgaacagg gcagagccca 607681 gatggtggat attagcgaaa aatcttcgac tgtccgtact gcggcggctg tttcaagcgt 607741 acacatgaag aatgaagtgt acgagaaaat acaaagtcac gatatcggca aaggagatgt 607801 actggctgtc gcacaggtgg caggcattat ggccgcaaag caaacgtcga atatcattcc 607861 gatgtgccat ccgctttcat tgagcggggt agatatatcg tttgactgga aaataaaaga 607921 agcagaagtt atacttcata taaaagcaca ggtcaaaacg aaagggagta caggtgtgga 607981 aatggaagcg ctcacttctg catcggtgtg cgctcttacc gtttacgata tgtgcaaggc 608041 ccttgataag ggaatggtca tcggccctac tttcttgctg gagaagacag gcgggaaaaa 608101 cggtgacttt aaaagagaac tatccgagta taatttggag gaccaaaaat gaataaggat 608161 caatcaaaaa ttccgcaggc gacggcgaaa cggctgccgc tttactatcg ctttttaaag 608221 aatctgcatg cgtcaggaaa acagcgtgta tcatccgctg aactcagtga tgccgtaaag 608281 gttgattctg ccacgattcg gagggatttt tcctattttg gagctcttgg caaaaaagga 608341 tacggatata atgtggatta tttgctgtct tttttccgga aaacgcttga tcaggatgag 608401 atgacagacg tcatcttgat tggtgtcggg aacttgggaa cggcatttct tcactataat 608461 ttcacaaaaa acaataacac aaaaatttct atggcttttg atataaatga gagtaaaata 608521 ggaactgagg taggcggcgt gcccgtctat aaccttgatg accttgaaca acacgtaaaa 608581 gatgaatcag ttgccattct tacagtgcca gcagttgccg ctcaatccat tacagacaga 608641 ttggtcgcat taggaatcaa gggaatcctt aattttacgc cggcccgttt gaatgtgccg 608701 gaacacattc gaattcatca tatagattta gcagttgagc ttcagtcact ggtttatttt 608761 ttgaagcatt attcagtttt agaggaaatc gaatagaggg aaaggaggag cccaaatatg 608821 ccgatcggtc ctggaagcct tgctgttatc gcaatcgttg ctctgattat cttcggtccc 608881 aaaaagctgc ctgaattggg gaaagcagcg ggagacacac ttcgtgaatt taaaaacgct 608941 actaaaggat taacgagtga tgaagaggaa aaaaagaaag aagatcagta agttaggatg 609001 acacgaatga aagtgaatca aatgtcgctg ctggagcata ttgctgagct tcgaaaacgg 609061 ttgctgattg tagcgctggc gtttgtcgtt ttctttattg ctggattttt tttagcaaag 609121 ccgattattg tgtatctgca agaaacagat gaagcgaagc agcttacgct taacgcgttt 609181 aacctgacag acccgcttta tgtgtttatg caatttgcgt ttatcatcgg catagtcttg 609241 acctcgccgg ttattcttta tcagctttgg gcttttgtga gcccgggcct ctatgagaaa 609301 gagcgcaaag taacgctcag ctacattccg gtctctattt tgctgttttt agcgggctta 609361 tctttttcat attatatttt atttcctttt gttgttgatt ttatgaagcg gatttctcag 609421 gacttgaatg tcaatcaggt gatcggaatt aatgaatatt ttcattttct tctgcagctg 609481 acgattccgt ttggactgct gttccaaatg ccggtcatcc tcatgttttt gacaaggctc 609541 ggaattgtga caccgatgtt cttggcgaaa atcagaaagt atgcgtattt tacgctgctg 609601 gtgatcgcag ccctgattac accgcctgag cttctgtccc atatgatggt cacagtcccg 609661 cttttgattt tatatgaaat cagtatcctt atatcgaagg ccgcttatcg gaaagcacag 609721 aaaagcagtg ctgccgatcg ggacgtgtct tctgggcaat aataaaaaat ccatttctca 609781 tgcgagaaat ggattttctt tatttttggt tctttttgat tttaaatgaa aaggcgaaca 609841 tcttaaaaga aatgctgatg ttgtaagcgg cgaacaccat cagcaggatg gagtaaaatg 609901 accacatgct gcctggcgag cttgcggcaa gataagtaaa gatgcaccct acggcaaagt 609961 agatcattcc ccaaactacc gggtttctca taaaaataat cctccaataa tcaattgcat 610021 ttgtgtgctc tgctgttcaa ggtaattacg aacaggctca agctgcatga tgacgacgaa 610081 tgtattcatc attaaatggg cgaaaatcgg cacccatatc cgttttgttc tcgcatataa 610141 aaaggcaaag gtaaagccca ttgctgtata tagaaggaga tgcttcaaat cagcgtgaac 610201 aataccgaag ataaccgagc tgatcagtcc tgcgaaaaag aaattcgttt tttcgtacag 610261 cgcgccgaaa atgatttttc tgaagatgat ttcttctaat ataggcccga cgatggaaga 610321 aacgataatc atgagcggga ctgcctgaat gacatccaga atcgcttgtg tattttctga 610381 ttctcttccg atgccaaaaa cataatattc aatagagcct gctattcctt gagagaaaag 610441 ggcaatgaaa aaaccggcta tcgcccaaag gatagaaagt ccgattgagt ccttctgtcc 610501 gtttcgcagc gtttctttcg gaacggttct cagaatgagc agaacaacaa cgagacaggc 610561 gataaagctg ataacggacc ataatccttg tgcatgcagc atattttcat ctgtaggctg 610621 tcctccggca taaccgaatt taaataacaa gggaatcgcg attaatgcgg aaaactgcat 610681 gatgatatat gtcaaaataa taaaccaata ctgttttctc aaatggtatg tactcctttg 610741 ttaagtgggt ttcgttcatc tacagctatt gtaacataat cggtacgggg gtgaaaaagc 610801 taacggaaaa gggagcggaa aagaatgatg taagcgtgaa aaatttttta tcttatcact 610861 tgaaattgga agggagattc tttattataa gaattgtgtt agcactcttt agtgctgagt 610921 gctaaaatta catattcata ctattgagga ggttatttca ttgttaaagc cattaggtga 610981 tcgcgttgtc attgaactcg tagaatctga agaaaaaact gccagcggaa ttgtgttgcc 611041 ggattctgca aaagaaaaac cgcaagaagg caaaatcgtg gcagctggtt caggtcgcgt 611101 gttagaaagc ggagagcgcg ttgctttaga agtaaaagag ggcgaccgca ttatcttctc 611161 aaaatacgca ggtactgaag tgaaatacga aggtactgaa tacttaatct tacgtgaaag 611221 cgacatttta gctgttatcg gctaattctt aaataaacaa tacttaaaac atttgaggag 611281 gtcttgtaaa catggcaaaa gaaattaagt ttagtgaaga agctcgccgc gcaatgcttc 611341 gcggtgtcga tgcacttgct gatgctgtta aagtaacttt aggaccaaaa ggacgcaacg 611401 tggttctaga gaaaaaattc ggttctccgt taatcacaaa tgacggtgta acaatcgcta 611461 aagaaatcga gctagaagac gcgtttgaaa acatgggtgc taagcttgtt gctgaagtag 611521 ccagcaaaac aaacgacgtt gccggtgacg gtacaacaac tgcaacagtt cttgcgcaag 611581 caatgatccg tgaaggcctt aaaaacgtaa cagcaggcgc taaccctgta ggcgtgcgta 611641 aagggatgga acaagctgta gcggttgcga tcgaaaactt aaaagaaatt tctaagccaa 611701 tcgaaggcaa agagtctatc gctcaggttg ctgcgatctc tgctgctgat gaggaagtcg 611761 gaagccttat cgctgaagca atggagcgcg taggaaacga cggcgttatc acaatcgaag 611821 agtctaaagg cttcacaact gagcttgaag ttgttgaagg tatgcaattc gaccgcggat 611881 atgcgtctcc ttacatggta actgactctg ataagatgga agcggttctt gacaatcctt 611941 acatcttaat cacagacaaa aaaatcacaa acattcaaga aatccttcct gtgcttgagc 612001 aggttgttca gcaaggcaaa ccattgcttc tgatcgctga ggatgttgaa ggcgaagcac 612061 ttgctacact tgttgtgaac aaacttcgcg gcacattcaa cgcagtggct gttaaagctc 612121 ctggtttcgg tgatcgccgt aaagcaatgc ttgaagacat cgctgtcctt actggcggag 612181 aagtcatcac agaagatctt ggccttgacc tgaaatctac tcaaatcgct caattgggac 612241 gcgcttctaa agttgtcgtt actaaagaaa acacaacaat cgttgaaggc gctggcgaaa 612301 cagacaaaat ttctgcccgt gtgactcaaa tccgcgctca agtggaagaa acaacttctg 612361 aattcgacag agaaaaatta caagagcgtc ttgctaaact tgctggcggc gtagctgtca 612421 tcaaagtcgg cgctgcgact gaaactgagc tgaaagagcg taaacttcgc atcgaagacg 612481 ccttgaactc aactcgcgca gctgttgaag aaggcatcgt atccggtggt ggtacagcgc 612541 ttgtaaacgt atataacaaa gtcgctgcag ttgaagctga aggcgatgct caaacaggta 612601 tcaacatcgt gcttcgcgcg cttgaagagc caatccgtca aatcgcacac aacgctggcc 612661 ttgaaggatc tgtcatcgtt gagcgcctca aaaacgaaga aatcggcgta ggcttcaacg 612721 ctgcaactgg cgaatgggta aacatgatcg aaaaaggtat cgttgaccca acaaaagtta 612781 cacgctcagc tcttcaaaac gctgcgtctg tagctgcaat gttcttaaca acagaagctg 612841 ttgtcgctga caagccagaa gaaaacggtg gcggcgcagg aatgcctgat atgggcggca 612901 tgggcggtat gggtggaatg atgtaataaa gggatattaa cccttataca tcaatgtttt 612961 aaccgtctta aaaaactaga caaagcgtga ataaaaaaag agaaggtctt tcatcagttt 613021 actaaactgt tgggagacct tttctccata ttagcggtca tatgagcata aatgtccatc 613081 gtcgtattta tgtccgaatg accaaattgt tgctggattt ctttaatgcc tactcctgcc 613141 tcaattagta aggaggtatg ggtatgccta aaagagtggg gggtgacatt ctttttatcc 613201 cagctttttt gagcagccgt ttaagtctag tctcaataac ctttcttaat tgcggatgac 613261 catcctcccg ctcaaaaata aatgatgagt cttgataaat caatctattt ttaagcttaa 613321 tttcattttg ataaatttta ttttttttta gtagattgac atcgtttcat caattcgaac 613381 gatatcaaca gatcctgttg ttttaggtgt tagcaattgg tatttttcaa tttgattgtt 613441 aggggtgtat agggtctttg tgacctggct tatcattgaa atctgtccat tttaaagcaa 613501 gaagttcacc aattcttagg tcggtctagg caagtacggt aaagaccaaa tggtccattt 613561 ctagcccgtc agattgagcg agctttagaa aatgtgtcag cacctctttt tccaatgctt 613621 tgttgcttct tgggtaattg aaaatcccca gttgggttca ttttaataat cccttgagtt 613681 ttagcttttc ggaaaatcat acggccgcag gcatgaatac ctcccaaaca attgtgactg 613741 tattgctcgt tcagttctaa cgtgcggtct tcatacattt ttttgtgttt tgctaatcgg 613801 gtattgaccc aatactgcga taaaatgcat cattttcttt tcactggccc gtacactgct 613861 tatttttacc ccactccggt tgtaaatctt aagccaacct tttgcaaatg ttttgaaggg 613921 catatctgac tccttaataa aagtcccgtt gtcgttttgg agttctacgt gacgggctgc 613981 tactggggct tctttctttg ttttaaatct tcctttggat atttctagac gttttttggt 614041 taaagggtca atgcctagta gatatgataa ctccacgtct taccgcattg cttgagtttt 614101 gccatttatt tgtccctaac taattttttt tcatcaaatt ggtctttaag tgagtttaat 614161 aatttttgtt tctctcgact ggtcaataat tgcccttcat atttcaaaag attggataaa 614221 tttgagatgg aatcaatcct gatggatggt accgtagact ttaataagaa acgaaaggcc 614281 aactgcgact tcagttggcc tttcctattt ataataaaga aattgagtga gattgctgac 614341 agaactacgt actactcgtt ttctttagtt gcccttgcta atcgttcaac ctctccccga 614401 atcccaatcg caggctccca cgaatcaatc aaacgaatcg ccttctgatt agattccacc 614461 gctttcgttt tctctccttt acgatacaac agctgcgcca ttccgtagtg atagtagatc 614521 agttcaactt gattggcgtt atgtttgtca tagagcattt gctcaaaggc ttcttccgct 614581 ttttcaaact gatcacattt cacgtaagcg acacccagat tgaaataggc ttctatcgtt 614641 ttttcgccgc cgtatgtgga gctgatttca tttgccgctt cgtataattg aatggcttct 614701 acatgataac ctctcgcaaa gcttaagtca ccgcgaacca atagaactct gtgttgaatg 614761 gtaggggaaa tcggttgatt ttcgatttcg tttaaaattg tctctgcttt ttcctgttgc 614821 ccgtctttta aaaacagcct tgctttgagt gcatgtcccc aaacctttag atcataggca 614881 tcgtgagcgt ctgattgttc aagaatcttc agcccggctt ctatttgctg aagcgctccg 614941 tctaaatcat tgacttccat caatgcccag cctgaggtgt cgattcggaa gtacgcttct 615001 cgtgtgtgtt ggcctaagtg atgggcggcg tcggccgctt tgcgtccgta ttcgattcgc 615061 aggggcaggt tgattctgct tagaaaatgg ctaatgcggg tgatgagttc gattaggatt 615121 tctttttgtt cagtttcact tgcccattgg atgaccttta agatgtttgg ccattcttgt 615181 ttcatttgat ctaagttccg tcccagcagg tagctccaat agatagagtt gggctgttcc 615241 cgctttaaat gggtttcggc ataatcaata taatagtgcg cccagcgatt gcgggcttct 615301 ttttcatatt cgtgctgttc ggacaagtgc tgttctccgt aagcgacaac ggtttggtgc 615361 gctaagtatt gtgtcctgcc ttggcttcgt tccggctgaa tcagcgcata tgaccgcatt 615421 tgttccatag cgtaatgaaa acggcgggcg tctaatccgg ctgctgccgc caggcttttt 615481 tcatcaggcg gcttgctgaa aaagcaaagc gtctgccaga gctttcgcgt atcttcattg 615541 catctatccc aggtgcggcc aaagaggaat tcaaacaatt ccagcagtga gtagcctgct 615601 tttccaagct catgaatcag ctgctgagcg gggatgtcat cgtctgacat ataggcaatg 615661 ctgagtgcca tggctttcgg gtttccggca gtcgctgaaa tgaattcgtt tttcaggtca 615721 gatgatagat gtaacagctg ctccagcttt tcccgtttac gtgggaggtt gcatgtttgt 615781 aagcagtgat gcacttcttg ttgaaaaaat tcgtgggcat ctgtttggtc aagaccgctt 615841 agctgaatgg ctgtcatttc tccgaagctt tcccgataag tttgctttac gttttcccgc 615901 gctgtaagga gaacttttac gccttgcgga aggctggtga taaattcatg aatgtcacgt 615961 tctgcagtat caatgctgtc aacgatcagc aggatcggtt tttctctagt gtaattggct 616021 aacgcattgc ggacgacaaa ccgttttaca ttgattgatt tatcgatttg ttctttgcgt 616081 ccgagctgat aggcgatcgt atttaaaaaa tcgctaaagc ttaatccttt ccaatcagcg 616141 ctgacccaga tgatgctgtt gaatgccggc caaactgaag tatcgtcgac acaggaatag 616201 gcggcttcaa gagcaattgt ggtttttccc atgccggccc agccggtgat taaacagact 616261 ggtgatggag aaagcatcca ttgccgtatc gcttccatat caaagctgcg tccgataaag 616321 cgtccggacc agcgtgaggg taaattatgc gtgatgggct gttctgtaag cgcattcgtt 616381 tcttggccgg gtctgtcatg aaacagccgt tttactacat tttcaatttc gccttcactc 616441 ggagccccga ataatccgtc ttttcgcagt attttcgctt ttttcaaaca ggatgctgcc 616501 catacaggca atgcgggttt gatgactggg atagtggtgg cttccagcaa gtcggtcaac 616561 cactcgatat ccaagtcggt cttttcgaga atgatccaga tcattccgaa cagttttccg 616621 tcgtcgattc ttccgggaat gtagtttgcc cccatctgtc cgatccagct tttgatcgtg 616681 tttggggaga ctcccagctg gagtgcgatt ttatctatgt aagactgtcc tgttttttca 616741 ttctttttcc ttctgacttt ataatcagga tgaagtttta gcgttttgac gccaggtgcc 616801 agcatttgtg caaattgttt tcggttttca agttcagcca taagcctgca cctcctatta 616861 gtactatttt atcaatccag cgttttttgt atatgaaaaa ataaaagtac agtgccgctg 616921 tccttttata cagcaggaaa ggctgttgaa cgtgttaaaa agcagataaa atgggggcag 616981 taacagagaa aacaaaaatg tatgcactta cattttattt tctaaagaaa ggaacttgcc 617041 aaatgactca cacagtacct caaaacatga aagcggctgt tatgcacaac acaagagaga 617101 tcaaaattga aacattgcct gtgcctgata tcaatcatga tgaagtgttg attaaggtga 617161 tggctgtcgg aatttgcgga tctgatctgc attactatac aaatggccga ataggcaact 617221 atgttgtgga aaaaccattt atccttgggc atgaatgtgc gggtgaaatt gccgctgtcg 617281 gatcatctgt cgatcaattc aaggtgggag accgcgtcgc tgtagagccg ggtgttacgt 617341 gcggacgctg tgaggcgtgc aaagaaggac gctataatct ttgcccggat gtacagtttt 617401 tggctacacc gccggtagac ggtgcgtttg tccaatatat taaaatgcgt caggactttg 617461 tttttttaat cccagactca ctttcttatg aagaagctgc tttgatcgag ccgttttctg 617521 tcggtatcca tgcggcggcc agaacgaagc tacagcccgg atcaacgatt gcgattatgg 617581 ggatgggccc tgttgggtta atggctgttg ccgcagctaa agcatttggg gcaggcacaa 617641 tcattgtcac cgacttagag ccgctgcggt tagaagctgc gaaaaaaatg ggagcgactc 617701 acattattaa tatacgtgaa caggatgcac ttgaagagat taaaacgatc acgaatgata 617761 gaggcgttga tgttgcttgg gaaacagcag ggaatccagc ggcattgcaa tccgcactgg 617821 cttctgtgcg ccggggcgga aaattggcga ttgtcggttt gccttcacag aacgagattc 617881 cgctcaacgt gccgtttatt gcggataatg agattgatat ttacgggatc ttccgttatg 617941 ccaatacgta tccaaaggga atcgaatttc ttgcttcagg cattgtggac acgaagcatc 618001 tagtaacgga ccaatattcg ctggagcaga cgcaagatgc gatggagcgg gcgcttcaat 618061 ttaagaatga atgtttaaaa gtgatggtgt atccaaatcg ctgagtgaac agggaggatc 618121 ttcgtattct ccctcttgtt tactggaaat gaaaacggat tcttggggtg ggaaatgatg 618181 attggaacag aaaaagtaac ggcattgaag gcgaagcatc agtcaaaatc cagcaccggc 618241 ctgtcctggt ttgaacgaat cggttatgga ttcggcgata tgtcgtataa tattatcttt 618301 cagtttgtaa acgcatactt attattttat tatacagacg tcggcggcat tcagcctgcg 618361 gtaatcgcaa ctttgtttct tgttgtgcgt gtgctggatg ctatttttga cccgatcatg 618421 ggattgattt tagataaaac gaatacaagg tggggaaaag caaggccata tttgctgtgg 618481 gtggcatttc cttttgcgct attcacattc ttatgtttca cgacgcctca tttcggtgag 618541 accggaaata tggtatatgc gtatgtcact tatattctgc ttgggatgtc ctttagtatg 618601 caaacgatcc cggtgaacag cttaacgggg cggatgacga attcggtgga ggaacgaacg 618661 gttctgacca caacccggat gattttggtg tatatcggca ttcttttatc catttcctgt 618721 gcgacaccgc ttgcaactgc tatcggagga gaggatcagg cgtttggatt tcagatgacg 618781 gcgctcatct atgcggctgt cagcatcgtt ttgaatctat ttagtttctt tactgtacgg 618841 gagcggattc agcctaaaaa gagaaaaaaa caagggatca aaaagacgtt atccgtttta 618901 ttcaaaaaca aacccttgct catgttaatt tcatcatttt tggcttttgc gatcgggttt 618961 aatattaagc tcagcacgat ggtgtattat tttacgtata acgtaaacca taaagagttc 619021 gtgtttatgg gcaccgtttt atttttcggg gcagcgctga tcagcaattt gtttattcct 619081 ttcttttctg agaagtgggg cagaaaacaa gtcatgatta tcacggcagc tctatcgctt 619141 atttcttatg ccggcctgca ttttacgccg tattcttcaa ttccactcat tttcatttgg 619201 cttttcgctt cgggattttt cacaacgcct ttaaatacgc ttgcttgggg aatggttgcg 619261 gattgcgtcg attatgcgga atggaaaacc ggaattcgcg cggatggtgt tgtgatttcg 619321 agcatgagct ttattaataa gctgggtgtt gcgttagccg ggtcattttc ggccatttat 619381 ttaggaatcg ccgggtatgt ggcgaataca gaccagacag ttgcgtcgtt gaatgcgatt 619441 aaaaatatga atgctttgat tccgggattt ttcattttgc tttctattat tcttatcgcc 619501 ttctatcctt taacggaaaa aagatataaa cacatcatct ctgagctgga gcaaaggtct 619561 gcgagataaa tagatgtaaa atttttaata ttcaatgttg tatttatggc aaaaagtaat 619621 atactgagac tgtaatctag actttataaa tgagtgtgat aatatgcgta gtcattctgt 619681 agtttgtatt ggggaattgt tgattgattt cttttgtacc gatgttgacg ttgatttaat 619741 ggaagggcgc caattcctga aaagtgccgg cggggcaccg gcgaatgtgt cggcagcgat 619801 tgccaagctg ggcggagacg ccgctttcag cggaaaagta ggaaaggatc cgtttgggta 619861 ttttctgaag cgaacattgg acgctgtaca tgtcgatacc tctatgctgg tgatggatga 619921 gaaagcgcct acaacgcttg cttttgtttc attaaaacaa aatggagagc gtgactttgt 619981 ttttaataga ggcgcggacg ctttgtttac gctggaggac attgaccagg aaaaactaaa 620041 cgaagcgaaa atccttcatt tcggctctgc gacggcactg ttatcggatc cgttttgctc 620101 agcctattta cggttgatgt cgattgcgaa agacaatgga cagtttattt cgtttgaccc 620161 taactaccgt gaagatttat ggaggggaag agtctcagag tttgtaagtg ttgcgaaaaa 620221 agcgatcgct gtaagtgatt ttgtgaaagt cagtgacgag gaacttgaga ttatcagcgg 620281 tgtgaaggat catgaaaagg gagttgcgat ccttcatgag atcggagcca acattgtcgc 620341 tgtgacactt gggaaaagcg gaacgcttct ttccaatgga aaagaccgtg aaatcattcc 620401 aagcattccg gtgacatcaa ttgactcaac aggggcggga gatgcttttg tcggtgcggc 620461 tttatatcaa ttggcaaaca cggatcagat tcaatctgta gatgctgatt ttgtgaaact 620521 gcgtgagatt gtggcgtttg ccaataaggt cggagctctt gtgtgcacta aaattggagc 620581 gattgatgca ctgccgagtt tggatgagat tggagtttct ttgtaaatca ttgaagatgt 620641 ttcttgaaag tctttggact tttgggggca tcttttttta ttgcttacat ttttgttcag 620701 gtaaaaagtt gtatattttt tgtttgaaat gtcatttttt attaaaaaag tgaaactttt 620761 aacgataata aatagtatat gtaacaaggg ttaccgaatt agctttagga ggaacgatat 620821 aatgagtata attggaagat ttaaagatat tatgtctgcg aatatcaatg ctttattgga 620881 caaggctgaa aatccggaga aaatggtaga tcaatattta agaaatatga atagcgattt 620941 ggctaaggtt aaggcagaaa cagcagctgt tatggctgag gagcagagag caaaaagaga 621001 atatcacgaa tgccaggcgg atatggaaaa gatggaaagc tatgcaatga aggcgctgca 621061 agccgggaat gagagcgatg cgagaaaatt tcttgaaaga aaaacatctt tggagtcaaa 621121 gctttctgag ctgcaggcgg cgaatcaaat tgctgcaacc aatgccgcac agatgagaaa 621181 gatgcatgac aaattggtat ctgacattgg agagctggaa gcacgcaaaa atatgatcaa 621241 ggcgaagtgg gcagtagcga aaacgcaaga aagaatgaac aaactgggcg cttctgtttc 621301 aagtacaagc caatcaatgt ctgcattcgg ccgaatggag gacaaagtaa ataaggcact 621361 tgatcaggcc aatgcaatgg ctgaactgaa cagcgctccg caggatgata tggctgatct 621421 gtctgcaaag tatgacactg gcggttcaag ccaggttgat gatgaacttg cggcgttaaa 621481 agcgaaaatg atgctcgata agtaatacat aggaggccgc agctttcggc tgcggcgtca 621541 ttttatcata aaatgtgaga gggaacggta atgataatat cttataagtg tccgaactgc 621601 ggcagtgata tggcatttga cagtgaaacc ggctcgttat cctgcagcag ctgcggaaga 621661 caggacaata ttgaaagcct tccgaaagaa aacattgcgg cacggttttc tgatgatgaa 621721 gcaaaagaat atcaatgtaa aaactgcggt gccgttttga tcacggaagc tgaaacgaca 621781 gcaacgacgt gcagcttctg cggaggtgct gcaatacttg ccgatcgttt atcaggacat 621841 ttggcgccgg cgaaggtcat tccatttaca atcagcaagc aagaagcgga gcaggcattt 621901 cgaaagtggt gcaaaaaagg ccttctgaca ccaagaggtt tcatgtctgc tgatcgtatc 621961 aaaagcatca ccggcatgta tattccattt tggatgtttg atttaaatag tgaagtacag 622021 gtgagagcaa actgtaccag agtccatcaa tatgaagaag gggattatat ttgcacggaa 622081 acagagcact ttgaagcgtt tcgtgatatc aatctcgatt atttgaaaat ccctgtcgat 622141 gcctctgaaa aaatgaaaga cgaattaatg gacaaattgg agccttattc atacgaagag 622201 ctgaaggact ttcaaacggc atatttggcc ggttatattg cggaaaagta caattatacc 622261 gatgaggagc tttttccgag ggcaaaagag aaaatcagca gttatataga ttcatacatc 622321 cattctactt tttccggata tacgtcagtc aatgtgaggg acaaacatat tcacacgaaa 622381 aacgtgaaca gcttttacgt tttgcttcct gtttggatgg tcagttacga ttatgaaaga 622441 gcggagcata tctttgcgat gaacgggcaa acaggaaagg tcgttggaaa gccgccgatc 622501 agtcgaggaa aagtggctgc atggtttagc ggaatagcag gcgggacatt tcttgcgttg 622561 aagctcgtct cattgatgat gggaggcgga ttttgatgcg tggatttttt gggaaagcga 622621 tctttgttgt gctggctgtt ttcatcatga tgcctttact gggtatcgaa gcggtaagag 622681 cctctgaatt gcagcagcat gtgtacgatc gcgctcatct attgtcaaaa gcggagatcg 622741 gaaaacttga atctctctcg gcaaagctgg gtgcaaagag ggacactgat ttcatcatta 622801 ttacgaccaa aagcacaaac ggtgaagata ttgcagacta taccggcgat ttttatgatc 622861 gttacggaaa aggcagtaca gccattctga cgattgatat gacaaacaga gaagtgttta 622921 tcgcaggctt taaaaaagcc gaacagtatt tggacaacag caggctcaat agcatcagaa 622981 atacgatttc atctgattta tccaatgaaa attattttga agcttttgag acatatattc 623041 agctttccta taaagatatg ggcataaaac cgggagtaaa ccctgacaac atattcttta 623101 catggtggtt tcagctgatt gctgccatcg cagtcggggg aattgcggtt tcaatcatgc 623161 tttatcatgc aggcggcaaa gtaacggtta atggaagtac atatatggat cagcgtacgt 623221 ctgatgtgat tgatcaatac gacacttata ttagaacgac tgtaacaaga gaaagaaaac 623281 catcagataa agacagcggc agcgatggcg gtgttacgaa aggcggcacg tcatacagtg 623341 ggagccgggg cagtttttaa atgtaagaaa tagagaaagg gagaggcgta atgtcgtttt 623401 tcagaaatca attagcgaat gtagtagagt gggaagaatt tagagatgat atgatttttt 623461 ataaatggaa caatcgtgaa atcaaaaaag ggagccgttt aatcattcgt cccggacagg 623521 atgctgtctt tttgaacaat gggcgggttg aaggagtctt tcaagatgat ggcgattatg 623581 atattgaatc agaaattatt ccattccttt caacgttaaa gggctttaag tttggcttta 623641 acagcggcat gcgagctgag gtgctgtttg tcaatacgaa ggaatttacc gtaagatggg 623701 gaacaaaaca ggcgataaat attccggcag cgggaatgcc aggcgggatg cccattcgcg 623761 caaacggcac atttaatttc aaggtgcagg actatatcag cctgattgat aaaatcgctg 623821 gcgtgaaaga tcaatatttt gtagaggata ttaaaacccg tatcatttct attctggatc 623881 agcttctcat gaagtggatc acaagagaag ggaaagatat gtttaatctt caagcaaacg 623941 cttttgatat tgccaaggga attcaagagg acttagatat gcaattaata agcgacggga 624001 tgacggtcac tggttttcaa atcatgagct ttaattatcc tcaagaggtt caagatatga 624061 ttacaaagaa cgcttcctac ggtatggttg gggatgtgaa cagataccag caaatatcaa 624121 tgacggatgg aatggcatcc ggaaagatga gcggaagcgg agcggcttcg gatatggctg 624181 gaatgatgat gggaatgaat atggccaatc agatgatgaa ccaaatgaat cagaatcagc 624241 aggcacagtc atcaggccca cagtcaactg gcagcggaag caaaccgaat ttctgtccaa 624301 actgcggaac aaaaacgggc gaagccaatt tttgtccgaa ttgcggccag aagcttgtat 624361 aagaatcata cagtgaaaag tccggagtga tcagcactcg ggactttttt atttaggaga 624421 ataagcatta cctattgctt gctcctgaac aggccatttt cgagcccccg cttggataat 624481 tcccagcagc aattgacgac gttcctttat tgaattgacg gcaatttgaa atgtttgctt 624541 tgataaagcc ggtatgcctg attgttgaag ctttgagatg tctggttctg gcggcgcttg 624601 ttctgcagga tggatatagg cagtatgaac ggtatccaga tagtttttga tacttgagcg 624661 cgcttctttg atatgaagct gattcggctg atattgttca ggaattccgt atttgaaaat 624721 ggttagagcc tcatccaata cagcaacagc tataatggat gattcctgat gctgcgtgct 624781 gtggtaaaaa tgaaggatgg ggaaggcgtt atgctgagcg gtcagctttc ccagttctga 624841 tgaggcagcg acaagaagaa aatcaatgtc gtgaaaatct ttgccattcc atgcattatg 624901 gacgatttca gttccgtcat gccctagact taatacactt tgggcaaagg agcgtttttg 624961 attaaccgca ctcaagacgg aaatcaaata cgtgacagaa aatgtgatgg taagcagtcc 625021 ttgagctgtt tcaataatcg tgacaagctt ccataggcct ccgttcggag cgaggtcgcc 625081 atttcctaat gtaaacatga catagccgga aaaataaatt cggtctgacc aggaagccgg 625141 ttcttttgat tgagtttcca taagtgagtg agggtcactc gagtaaatca aaacccaccc 625201 gctccaaaat agactgatcc atatcactaa cgtcaggcat aacagcagag gaccagccat 625261 acttagaacc tttgcgtggt caccgctgat tttgcggcag cccttccaca gccaggcaga 625321 caggcatctt gtgatcgggc cggcaccgct ctctaaccat aacgtggtcc ataaaaaatc 625381 aatcatcccc gctgtcaata ataaaaggcc tgcaatgata taaccctcat tcattttggt 625441 tgcctccctt aagtcagcct tcttttattt tcttctctat ttccttttat cctgagtctg 625501 aaacaattga acgaatgttt gattttacag agaaaaatag gtgggagtta cccaacactt 625561 actcattttt caatatgaac agaaaatcac aagatttttg acttgattca cacattttca 625621 tgaagaaaaa cgttcatttt ccccttgaat tggtgatttt ccttttatag agtaaaaaat 625681 tttcagaaat ttatattgac tgaaagcgtt tttataatta tgataatatc agatataaca 625741 aaaatgtcac tataacatca ctacaattga actattaagt gactaataaa taccaaatga 625801 acgaggttat gcacaaagaa atgaccattg ttcttttaac gagaaatgaa atcgcttcca 625861 tagggattga catgctaaga agaagggaag gttatgaggt tattggataa aaacatgaac 625921 aactattttc tgaagcctgc ttacgaaatg tgaggaaggc agcagccctg gaataagttt 625981 ttgacatacg cattttgaaa aagactgggg gaaacagtat gaataaacaa ggaaatcaaa 626041 tgtcattttt acgtacaatt attttagtct ccactttcgg cgggcttctt tttggctatg 626101 ataccggtgt gctcaatgga gctttgccgt atatgggaga gccggatcag cttaatctca 626161 atgccttcac agaaggcctt gtcaccagtt cacttctttt tggagcggca ctgggtgctg 626221 tgtttggcgg caggatgtct gattttaacg gccgccgcaa aaatattttg ttcctcgctg 626281 ttatattttt tatttcaacg attgggtgta cgtttgcacc aaatgttacg gtcatgatta 626341 tttcccgttt tgtgctcggt attgcggttg ggggtgcatc cgtaacggtg cctgcctatt 626401 tagcagagat gtctcctgtg gaaagcaggg gacggatggt gacgcagaac gaattgatga 626461 ttgtatcagg acagcttttg gcctttgttt ttaatgcgat ccttggaaca acaatgggag 626521 acaactccca tgtgtggagg tttatgctgg tcattgcgtc acttccagcc ttgttcctgt 626581 ttttcggcat gatcagaatg cccgagagtc cccgttggct tgtttctaaa ggaagaaaag 626641 aagatgcttt gcgtgtattg aaaaaaatca gggacgaaaa acgggcagca gctgagctgc 626701 aagaaattga attcgctttc aaaaaagaag accagcttga aaaagcgaca tttaaagatc 626761 tttcagtccc atgggtgcgc cgtattgtgt ttattggatt agggattgcg attgtacagc 626821 aaattacagg tgtgaattcg attatgtatt atgggactga aattctaaga aattccggtt 626881 tccaaacgga agccgcttta atcggaaata ttgcgaatgg cgtgatttcg gtattggcaa 626941 cattcgtcgg aatctggctg ctgggaagag tggggcgccg gccgatgctg atgacaggct 627001 tgatcggtac gacaacagca ttattgctaa tcgggatatt ctcacttgta cttgaaggat 627061 caccggcact tccgtatgta gtcctgtcat taacggtcac atttcttgct tttcagcagg 627121 gcgccatttc accagtgact tggctgatgc tatctgaaat tttcccgctt cgccttcgcg 627181 gactgggaat gggtgttacg gtattctgtc tgtggatggt gaattttgca gtcagtttca 627241 cgtttccgat attgctggca gctatcgggc tgtccacaac gttctttatc ttcgttggat 627301 taggaatttg ctctgtcttg tttgtgaaga ggtttttgcc ggaaacgaaa gggctttcgc 627361 ttgagcagct ggaggaaaac ttccgcgctt atgatcacag cggggcaaag aaggattctg 627421 gggctgaagt gattggataa tttaaaaaag aatccgcacc cgagtgcgga ttctttttgg 627481 tttcaaatta gttaggtcta acaaggattt tgacttggct tttctcttta ataagagccc 627541 cgaagccttc ctcgatcaaa tcatctagta cgattttttt cgttacgagt ttgtcggctg 627601 agaaatagcc ttctttcatt aatgacaata cagccgggaa gatgtcgcgg tatccgataa 627661 ttccttttac tgtacgttct ttgattacga tatcgttcgg atggatttca gcaccttttt 627721 cccaaatgct gacgatgacg gtttcaccgg caattgtagt ggactggatg gcttgtcgta 627781 acaccactgg gacaccagtg acttcgaatg ctacgtcaac accgcctcct gtacgttctg 627841 caatctcagc gactacatcg tctgttttag acggatcaac gatgatcgcg ccaagctcct 627901 cagctttttg ctggcgttca ggagaaagct caacagcgta aatatcagtt gcaccggcag 627961 ccttcagcgc ttcaatgaca agaagtccga tcgggccgca gccgaataca gccgctttgt 628021 cgcctgcttt gagtttgctt gagcggacag cgtatagagc aactgcagaa ggttcaacga 628081 gcgcgccttg ttcatatgat aattcatcag gaagtttgaa caaaagctct tcatccacag 628141 agacgtattc agagaaaccg ccgcctccgc cggctaagcc gaggaatccc atttgttcat 628201 caaggttgta ggcgccttgg tggccgtgtg tagcaaaaat cggctcgact acaacgcggt 628261 ctccaacttt ataattttca acgccttctc cgacttcgac aacttcaccg gagaattcat 628321 gccccattgt gacaggtgcc gtttcatttg ttaatgggtg cggtttgtca accggaataa 628381 agatcgggcc gcccagatat tcgtgtaaat cacttccgca gatgccgcac catttgactt 628441 tgatctttac ttttcccggc tccgtttttg gctcttcgat atgttcaata cggatatcct 628501 tttggttatg ccatcttgct gccttcatgg attaccactc ctataacttt tgatgtgagt 628561 aattccgcac cggtcaatat gaactgttca caaaatcgcc atttttaaaa ccaaaaaaga 628621 aatgaaattt ttatataata taatctacgt ttttttgaaa aaaagaaact ttaaagaaaa 628681 aagggtctcg cacactcttt tttctttata tgagagtatc aatcgtttac atagctatga 628741 atttggtttg aacaatacgg taatggttcg ttcatattga atgcgacaac tactctatca 628801 ataattataa ctctaatact gctattataa taggataatc ttccatggtt tattttagca 628861 gaggtaactt ttttgacttt gtaacattac tgtaaggata ttgaaataaa aaatagctgg 628921 ttgatcgtgt ataatcttcc tagatgttaa caaacagggg gacgaaatgt tgaagaaagt 628981 cattttagcc gcttttatct tagtaggaag tactttggga gcttttagtt tttcatcaga 629041 tgccagtgcg aaacatgtga acggaaatat tacttggtat aatggagtcg ggaaaaaagg 629101 ctcttcaggt aagaaacttg gacattggga ttgtgcgacc aaaatcggat ttgatgttcc 629161 tagaaacggg acaaaaatca gagcttatgc aaaagcgaag cctaaaaagg tgattacggt 629221 ttataaaaat gatgttggca gaatgcctaa tgcagtgctg gatgttagcc ctaaagcgtt 629281 taaagcgctt ggatacccat taagcaaagg taaagtagcg gggcattaca gctattaatg 629341 tacatatata atctggaaag caagaagtca cattcttgct ttttctattg gtggagataa 629401 aagatgaaaa aaagaatcat attattatta gcagtgataa tagcggcagc tgccgcgggg 629461 gttgcgtttt atgttgcaaa ggataaaggc catgagaagg ctgctgatgt ttcagtcaat 629521 accgaaagcg gtgatgagct gctggtttca attacagata cggatctgct gacaaagtat 629581 tatgaaaatg acaaggtgat ccatgaggag aagctgacca gctatccggc atttgccttg 629641 gatcaaaaac agcaggtgct ctattatacg ggcaataatg aacagaatga aatgaggctt 629701 tttaaattgg atctgaagtc tcataaaaaa acgatgcttt ataaaggcgc ggagagtgcg 629761 gacagtttat ttttatcaaa ggaccgttca accatctatt tccgcttagg aaaagcggac 629821 gaaagcaatt ttcgaatcgc cgcttttgat ctgaagacga aaaagtataa aaatctttat 629881 cctgccgcta atgatcagga tgacaccgtc agcagcttct tttataacca aaaaaacgat 629941 tcatttgcat tgcttcatta ttctgtagaa gaagactaca agaaaacaga tgaagcaaac 630001 gaaaagggca tcgaccctga accgacaacg attcattttg cggaaggccg ccaaaataaa 630061 tttaatgagc tgaaaagcct gaaccaattt atcagcgata ttgctgtttc tgatgatgat 630121 aaacgtattt tattcacatc atatacgcaa aaaggaacgg agcaaaccgc ttctattcaa 630181 atgctcaatg cggatacgaa aaaatatgaa agcatcatct caaatcaaaa atcatttaag 630241 ctgttaattg acgcacagcc tcagttttct aaggatggga agaacattta ttttcttgcc 630301 gaagccaagg gggctaaaaa gctgaaggac gaaacagggc gtgaagctaa ggtgcggacg 630361 atttattcct atagccttga gaataagacc ttcaaaaaag tatgggaaaa tccgaacggc 630421 atcatcaaca gcttttttgt gattaactaa taaaaaccac tcggcatgag ctgagtggct 630481 tttttaatgg atgaggtgca gggctaatga tccgagccat ttaaagatat gaatcagagg 630541 taccgacaaa aacagaagtt caacatatga gttcattgca acattcagct ttttgaacgc 630601 agctcttttt ttcaagtctt tttgctgctg gtttgagatc acgttatcac tcctcttata 630661 tccatattat accattaaaa cagacaaaaa agccctaaac gtttacagtt ttgggcttct 630721 ttcttcgtat ttggcctctt gcaatgagag gcttttattc tgaaatatag aattttgtct 630781 ccgttcgggg tttgtttgct tgcgggagac tgcatttgtt atagggaaga actagcttgt 630841 tttcgtttgg ctgttgtttt ggagattcac taatgaacgg atgccgtcga ccattttact 630901 tccgcacaaa gggcacaatg gcgtatcact gctggcgaag ttttttcggg tccagccatt 630961 acagtcttct tttgtgcatt cccaagtact cacatcttcc tttggcagcg gttcttgatt 631021 tcgtttgtta tagtaagaca taaagtcact tcttccctca tgtattttac tgcacatttc 631081 ctattgtctc atacttttcc ctaatctcct aattcctttt tctttatgac tttccaataa 631141 ccccatctaa aaaggagagg agtgtgctgt taaaagcatc tggctcttct aaaaacgggc 631201 aatggctgct tttaggaaag gtaacgagtg tcgcgtttgg aatattgctg cgcaagtgtt 631261 ccccagctgc tgtagagaaa aatttcttgt cttccccgaa gcacagcaat gccggcacat 631321 tgatgttttg gagggtgccc cggtaatcag cggccgtttg gttaaataaa atcgtgctag 631381 aaatggcagc cggctgtttg aggatttctg ccagcatcca ttctgtttcg gtctcggcag 631441 gcggttctgc gaacatattc tggatgaagc tttcgtagaa aggcagcggg tcagtttgaa 631501 tggcgtgcat cgctgttttt aagccgtcaa aatcaaatgg accatgttcc cagccctccc 631561 attgatagtc cgaagcggat tgatcgatga tcacagcggc ttgaatgtta tcattcccaa 631621 actgattgag ataatcccat acgacaaaag cacccattga ccagccggca agaacgacat 631681 gatcaagctc cattgcattt agaaattccc ttatgtcacg ggcatattgg gaaatggtgt 631741 ggccgtgaag cactttgtca gattcgccgt gtcctctaag atcaagacga atacattgat 631801 aattggcaga aagcaccgaa aattgtttgt ggaaaaattg tccgctcatc agcaccccat 631861 gtataaacag gatcggcgtc ccgctcccgt gtgtttcata gtaaaggcgt gtctgatctt 631921 ctaatatgat gtatggcatg tttctcctcc tttagtttcc atcatgagta tggctggctg 631981 ctgttgagct gatgatggca gctgtcgcgg ctgcctgctg cgcttgaatg actgtttcga 632041 tagcggtgta tagtcctgat tccatcagca gatttttctc catatgctca ctgagataga 632101 ggctgacagc aattttaaag ttcatttcct tttgccattt aaaagctttt tcctggttta 632161 attcgtcagt gatgcacaaa acggttttga tatctggctc ttccagaaat gtgaggagag 632221 caaggtctgg ataatgataa tcctttgttt ttttgacaga ttcagtgatc gattgatata 632281 tctgtttgca agcggaaaca agcatttcgg gctctttttc actttgcaag gccagaatat 632341 ggctgacctg atgtaagtac tgtccttttt taaagccgtt ggctgccagc agttgatagc 632401 atgtttccgc cttctgtagc gcctgcaaac cttttccgtt ttctccaagc agtacggcaa 632461 gcggaacatt ctgagttgaa gtgaggaaat aatgattttt cttcatctgc tgataaacag 632521 ctagccccat gttcatctgt tctttttggt ttgtcgtttc agatttgccg gtgagcaaga 632581 tcagagcgga aaggtatgtg aacatatccc gcttataccc tagcttcacc atttcattgt 632641 atacatcgat gaaagtctga aatgtttgtt ttgcctcatg ctgaaaatga atgtccagaa 632701 tagatgcaac agtaaagcgg tggtgtgaat tgagtgttga gaagctgccg atgtttgatt 632761 tgatatagct gctcaaatca taaaagcgct gaaaatcaaa ctctctttta ttcacaatat 632821 atgcagaaga aatgagcatt aatatctgat cgtgtgaaac tttccatttt aattttgttt 632881 ttaattcagc ataaatggaa atgtaatgct ttgttttttc atgtagatcg tgtgtgagca 632941 taaaaagcag ctccttttgt tgtttttacg taatacgata aatagggcca aaggtttcat 633001 aaagaaaaaa cttgcctgct agaggcaagt ttgtcgggtt atttatgggg atcagttata 633061 tccatcggtc tcatcatgtc atagtcttca tgctctagaa tatggcaatg ccatacgtat 633121 cgtccgctgt acggaccgaa tgtcgccgcg attctcagga cttcacctgc atgcgcttga 633181 atggtgtctt tccagccctt ttcacttggc ggcggcggga cagccggacc ggtataggac 633241 aattccccgc tttcttgata acgggcgata tcaaacggcc gccggtctaa tacacggaag 633301 gagactagat gcaggtggat cggatgtgtt ccgcgtgtcg ggttgataat ggaccatatt 633361 tcagttgtgc cgacttttgg tgtttctgtg acgggatcgt gccagcgttt gttattaagc 633421 agaaggacgg gtctgccgta ttcgtcctgg gtgcctgcca gttttaacgt tctgatgttt 633481 tgtattcttt catgctgtac cgaagggtat gaggcgaggt acttcggctt tctgctttcg 633541 tctttttgtg ccaatggttt tgtgactctg aattgcatga tattcgcatc tgtttcagga 633601 ttgacgtcac cgccgcagcc cgcgctgttt gccaaaatga tcgattctcc ttcatatgct 633661 gtgaagtcaa tgatgatatc gtaacgttca gcaggcgcaa ggctgaaaga attcagttta 633721 acagatcgcg gcaggagccc tccatctgaa ccaatctgaa taaaatctcc gccattatcg 633781 agtgacaggt tataggttct tgtattggag gcgttgatga cacggaatcg gtatttcctt 633841 ggctcgactt ccaagtatgg ccataccttc ccgttgacga gtatggtttc tccgcaaaaa 633901 gccggaacga ttgaaggatt aggcagtgac ggagaagggt tttccggtgc gctcggataa 633961 aacaaagaac catcctcatt gatcgtgcgg tctgtgataa gaagcggcac atcgtattcg 634021 tctgaaggca gttttaagcg tttttccttt gggtcatgaa tgatatatgc accgacaagt 634081 ccggcataga catttagcct ggtgagcgcc atggcgtgat cgtgatacca caatatagcc 634141 ccgcgctgct ggtttggata atgataaacc tctcttttga aataaggtcc tgtttgttca 634201 aagtctttgg aaaaccaagc ctccggatac ccgtcactat catctggcgt gacgccgccg 634261 tgtaaatgaa caacagtctt tacctcgggc tcttcatgct ggctgtcact gtgatgaatg 634321 gtgtgatcaa tcggaaggaa atgcgtggaa ggaaggttat tcatccattt tacatatacg 634381 ttttcatttc ttttaacctc aatggtcggt cccggaaata agccgttgta gccccacagg 634441 cgggttggag ggagatcgcg atggagctga tgagtgcatt cctccatggt gacttcgtag 634501 tatgtttttt cttttgattg ctgtactggc tttagtgtat ctgggattgg gagagcatcc 634561 acaaattttt caagtgtcat tttcatctgt ccttatctaa attttccaaa ttggtactat 634621 agttaatgac aataaggacg tgatggttac aaaaaatctt cgtgctgcag cccgcccgaa 634681 gaagaaaata acaaaatcct aaacggcagg ccgtttagga tttgatcagc attaaggcag 634741 gatatcgggt tgctgctgtg tgactgggtt ggcagccgct ttctcgctca ccttgcgttt 634801 tctgaacaca aggtaagaaa tcagaacgat tcccgtgatg acgcctgtca gcagcagctc 634861 gtctctcatg gaatcaataa acgccatgga cactaaaatt ccgcaaatgg cgatgatggt 634921 caagtaggtt aggaaaggga agagccacat tttgatcttc aatgcttctg ggtttgtttt 634981 ttcgagtttt ttccgcattt tcagctggga aacggcgatg acaagataga cgagtaaagc 635041 gattgcgcct gatgagttga ctaagaataa aaagacggta tccggtgaaa aatagttcat 635101 tacgaccgcg atataagaga aaaatgtccc ggccacaatg gcttgtacgg gaacgccttt 635161 tttgctcaat ttcataaaac ggcgcggcgc ttcatttctt tctgcaagtg aatacagcat 635221 tctggatgtg gtatacaaac ctgaattcag gcaagagagt acggctgtga ggacgataaa 635281 gttcataatc tgtgcggctg cgggcactcc tatatgctca agtacagcga cgaaagggct 635341 ttctaaaata tttgctgaat tccatggcaa cagcgccacg acaatggcga ttgagcccac 635401 gtaaaagacg atgatgcgcc atacaacgga tctggtggct tttgtcacag attcgatcgg 635461 gttggatgtt tcccctgctg caatggcaac gatttcagtt cccataaaag agaagatgac 635521 aacgacaatg ccgagcaata cggagctgat gccctccggg aaaaatccgc ctttgcctgt 635581 aagattcgaa aaaccgactg gctcactgcc cggtgcaaag ccaaaaataa aggcaaaacc 635641 aacgattaga aaagcaatga tagtcacaac tttaatgagg gagaaccaat attcaaactc 635701 accgaaagac ttaacggagt agacgtttgt cagggtgagc acaatggtca agatcaaact 635761 tgtcagccac agcggaatat catggaacca gtattgaata atgccagcac cggcaatggc 635821 ttcgatcgct atgacgatca cccagaaaaa ccagtacagc cagccgattg taaatcctgc 635881 ccacggtccg atggcgtcgt gagcgtattg agaaaacgat ccgctcgtcg ggtttacggc 635941 agacatctca ccgagcattc tcataataaa aatcaccaat aatccggcta acgcgtaaga 636001 aacaacggca cccggaccgg tcgagtgaat cactgaaccg ctgcctacaa ataggccggc 636061 tccgattaca ccggcaatcg aaatcattgt catatggcgg gtctttaatt ccttttttaa 636121 tcctgattga gactggttca taagttacct ccttttaaaa tgcaatcatt actgaatatt 636181 atgataattg aaactctatc ataaatatac agtttgtcga aaattcgtgt aagaaaatat 636241 accagcttat ttcaaatttg tagtgttttg tttgcgcttt cagcgaatgt gtggaaaaaa 636301 tgtttcgttt tttattcgct gtgtgatttt gcgtaatatt tacaattcga tagaatgcga 636361 gaagcactgg tgtccttggg tttgatggga tttttggcgg agcaaataaa ttggatgaga 636421 gaaaaagtgt tccttcgtca ctatttttct gtggcgggtg aatcatgttt ctgtagaccc 636481 actgcggatc agctttgtaa gataataata ggaaaatgtg agcgagagga ggttttgtat 636541 ggagagatat gatgaactga aaaagggaga atccggagcg ctggtcagca ttgccgcgta 636601 tctagttctt tccgcaatta aactgatcat cggttatctt tttcactcgg aagcacttac 636661 ggcagacggg ttaaataaca caactgacat tattgcttct gttgctgtgc tgattggcct 636721 gcgcatctct caaaagcctc ctgacgaaga tcatccatac ggccactttc gagcggaaac 636781 gattgcatcg cttatcgcat cgtttattat gatggttgtc ggactgcaag tgctgttcag 636841 cgccggagaa tctatttttt ctgctaaaca agagacgcca gatatgattg cggcttggac 636901 ggcagcgggc ggggcagtcc tgatgctgat cgtttaccgg tacaataaaa ggctggccaa 636961 aaaggtgaag agccaggcgc tccttgctgc ggctgctgat aataaatcag acgcattcgt 637021 cagtatcggc acatttatcg gcattgtggc tgctcaattc catcttgctt ggattgatac 637081 ggtcactgcg tttgtgatcg gtctgcttat ttgcaagacc gcatgggata tctttaaaga 637141 gtcatctcac tctttgacag atggattcga cataaaggac atttccgctt ataaacagac 637201 aatcgaaaaa atctccggtg tgagccgttt aaaagacata aaagcaagat acttgggcag 637261 tacggttcat gttgatgtgg tggttgaggt atcggcagat ttaaatatta cggaaagcca 637321 cgatatagcc aatgaaattg agcggagaat gaaggaggag catgcgattg attattcgca 637381 tgttcatatg gagcctttag aacaaaaata atggagcttc ctgtcacagg aagcttcagc 637441 gtgtcgacaa accctcgcat tcgttgtcag gtctgcgctt cggtgctcac gaattagaac 637501 attcgctccg ctcctatgct cgtccttcct agacttcaag ggttttcaat cacgctgaaa 637561 agatgacaaa accctaaaat gaaagccatt ttaggatttt gtcaacaatc tggagcttcc 637621 tgccacagga agcttttttg tgtgttttgg ccagctttat tggtaacaat ttgctagaat 637681 cgttttttta tacagattgc tttttgtggt aaagttaggt tacattatga tgaattttgt 637741 agatgactag gaggaaaata atggcatatc aagaagacct gcatcctttg ctggggaaag 637801 cagttgaaca tattaataga gtaatggttg gaaaacgaga catcgccata ctcagcttag 637861 cagcccttct tgccaaaggg catgtgctgc ttgaggatgt acccggagtc ggaaaaacga 637921 tgatggtccg cgcgctggca aagtcaatcg gcgccgattt caaaagaatc caattcactc 637981 cggatttgct gccatctgat gtaacagggg tatctatcta taatgcgaaa acgatggaat 638041 ttgaatatcg tcccggccca attatgggaa atatcgtgct ggcagatgaa atcaaccgta 638101 cctctccgaa gacacagtcg gctttgctcg aagcgatgga agaggggagc gtcacggtag 638161 atggccatac gatgcagctt gccgatccgt tttttgtgat ggcaacgcaa aacccggtcg 638221 aatatgaagg gacctatcct ttgccggaag ctcagcttga ccgtttttta ttcaaacttc 638281 ggatgggtta tccgtccttt aatgaagagc ttgacgtctt atctcttcag gaaaaaagcc 638341 atccgattga gacgcttgag ccggttattg caaaagaaga cttcatcttt ttacagaggg 638401 aagtgcaaaa tgtccgtgct gatgacagca ttaaggaata tatcgttgaa attgtgcaga 638461 aaacgagaca gcatccttct gttcaattag gcgtcagtcc gcgcggctca atcgccctca 638521 tgaaagcggc acaggcatac gcgctgctgc atcatcgcga ctatgtcata ccggatgata 638581 ttcaatattt agctcctttc acgctgccgc accggatgat gcttcatcct gaggcaaaat 638641 ttgaagggat tcaggcagaa gcgatcgtaa gggagatcat gtcagctgtg aaggtgccgg 638701 ttcaaaggtc ggcggtccgc tgatgaataa gaaatggcaa tggctcgtat atggttggaa 638761 gctgattata ttaactttat tgacggctgc tgttttttct tatgcgatgt ttcagggcgg 638821 ctttgtcagc tggtttttgt tttacgcgtt tctccctttt gtcttgtatg ccgggctgtt 638881 ggccttgtat ccgctccgtt cttttcaggc ttcaaggcaa atggataaaa cacaattgca 638941 tgcgggggac aggctgggcg taacggttac gctgagaaga aagctgccat ttccgctgat 639001 gtatatggtg attgaagatt gcctgccaga aggtatcgag tcattaaatc gagacggagc 639061 cgcggccaaa cggctcgttt ttccttggtt taaacggagc atgacgatgt cgtatgaatt 639121 agctcgggta ccgcgcggag agcatcactt tcattctgtc agggtgcgaa ccggggatgt 639181 tcttggcttg attgaaaaaa cagcattttt tgagctggat gataccttgt ttgtttatcc 639241 attctatcag cgtttttcct atcaggtgaa tgagaggcat caggaagacg gtgtaagcgg 639301 ttcttctcct attcatcagc accattcctc agtcgcagca agtgtgcgga attatcagcc 639361 gggagaccgg tttgctgcgt tagattggaa gacatctgca cggcggagcc agctgatgac 639421 gaaggaattt gagccttctc gcagcaaaaa tctgtttctg ctgatggacc gtttttcctc 639481 agacgcattc gaagaggtcg tttcagtgac agcttcgatt cttcattctg ttttaaaaaa 639541 cggcgcgggt gctggtctgg cttccatcgg gaaggaaaaa aacattttcc ctattcagga 639601 aggggatcag cattttaagc acatgcttcg gcatttagcc atcgctcatt gtgatgcggc 639661 agacccgata agccgatatg cacgggaaga gctgggaaag ccatctgttc gccaagctga 639721 tcaagttgtt gtcacgggac agttaacgga agatatgctg cacctcgcag aaataggagg 639781 cggccgggtt acggtgatac tggcaaaaga gaaagatgct gagctctctc aagctgaaaa 639841 tgtcatgatt gaacgcatga tgaaacgcca aatcagagtt cggatcatga ggggcgggcg 639901 agtttcgcgt gttgtttaga aagagaggtg actggttcac atgccgcacg atgatcacaa 639961 gggaagccgt ttgagcttgc tgttatttta ttttctggct tttttattgc tgtgggagtg 640021 gcttaggccg cttgacagtt ttactgaaac gaaacataca ggctttttta gtgtctttat 640081 cggcttgacg tttctgctga cttttttcag gatgaggtgg tttgtcaccg ttcctttttg 640141 tgtcatattt acattgatct cgatacacat cctgttttat caaggatcta tattcgactt 640201 gagctgggtc agctcttttt tgcaggatgt ctatctgaat atcacgctga ttcaatcagg 640261 gcaatggaat gacatgattc cttcatttcg gaccctgctg ttttttgtgc tgctgtggct 640321 gctggtctat ctcctgcatt attgggtgat ttaccagaga agaattttgt ttttcttttt 640381 gatgacagta gcgtatatta cgattcttga tacctttacg ccatatgatg ccacttttgc 640441 cgtaatccgt atcgtgctga tcggcttctt tatgctgggc cttttatact tggaacgcat 640501 taagctgatg gaaagaatca cactgccaaa aacatctgtc ctgaaatggt ttcttccttt 640561 atctgtattg gttttggctg caacgggatt cggactcgcc gctccaaaat cagagccggc 640621 ttggcctgat ccggtgcctt ttcttaaaaa aatcactcat caagaccgcg tgtctgcagg 640681 ggaaagcaaa atcggatacg ggaatcatga tgaatcactc ggcggcccgt tccagcagga 640741 tgctacacct gtttttacat ggcagggaaa agagcgtacg tatttccgtg tggaaacgaa 640801 ggacacgtat accggaaaag gctggattga aacagacaca ggcatgtcgt atcagcttag 640861 caatggaaaa gttgaaaatc tgtggtttga ccataaggtt gcgacagagc gccgcaccgt 640921 ccgtgtaaaa gtcgataagc actacgggta taaccatctg atgtatccga ttggtgcgga 640981 aaccattcag ccaaagcagg ctgtctcact tgaaatgaac ggcaacacgg agcaaatttc 641041 tccgatcagt gaacaagccg gtgaaatcag aaatatgggg aattatacag taacgtacaa 641101 ttccccggtc tataagctgg atgaactgag aaaggtaaaa gtgagaaaaa acagtgagga 641161 gtacacattc agcgatcgct acatgcagct tccagattca ctgccagagc gggtgagaac 641221 ccttgcgatc aaactgactc aggatcacga caatatgttt gataaggtga aagcggttga 641281 ggactattta gggtcaaatg cgttcacata tgaaacagaa aacgtgacca ttccgaagaa 641341 tgatgaagat tatgtcgatc aatttctctt tgaaacgaaa atgggttatt gtgataactt 641401 ttcttccgcc atggtggtgc tcttgcgctc ggccggcatt ccggcccgct gggtaaaggg 641461 ttatacgtcc ggcgaataca aagaagcagg gaacaaaaat ggcagcattt acgaagtgac 641521 aaataacaat gcccattcct gggtagaggt gtatttcccg gaacagggct gggttacatt 641581 tgagccgact aaagggttta caaatccggc tcaatttaca tcttctgaca caaaagactc 641641 tggcagcgat agcagcagct cgccgaagaa agcaaaagag aaacagaaag aagagaaaaa 641701 acagccgcaa aaagaggaaa aacaaaagga aaagcgggag ccagctgttt ctaaaaagcc 641761 gtccgcttcg catactaatg ccggtgcggg cttgtatgca gcgcttgcgg ttcttgcagt 641821 cctcctggtg gcagctgtat tgctgtatgt tttccgctcg ttatggattc ctgttttcgc 641881 cgtgaggaaa ttgaagcggc gcagtgatca gcacgcgttt tttgaggcat atggcgcgct 641941 gctgaaacaa ctgaagagaa aaggactgcc gaaacgagac agtgaaacgc tgcgtgatta 642001 tgcaaaacga attgatgaaa aatacgacat agaagacatg tcaaagctga cattaagcta 642061 tgaaagggcg ctttacagaa atgaagattc ttcggcgcta tggaatgatt cgagagagtt 642121 atgggaaaat ttaattaaaa gaagatggtc ttgaccgctt atcgacgtgt tgttagaatt 642181 agtgaatatt atcggagtct gggagcgagt tggcctgact ccggcaaacg gccttgccaa 642241 agagggcgga gcgagcttca tatctgtcct cgtttttttc tgtgtcaaaa aacttagagg 642301 agattaggtg acaaccatga caaagttagt gaatgaaatg attcttgtcc ttgatttcgg 642361 cagtcagtat aaccagctga ttacacgccg tatccgtgaa ttcggtgttt acagcgagct 642421 gcatccacat acattgacgg ctgaagaaat taaaaaaatg aatccaaaag gaattatttt 642481 atccggcggt ccaaacagtg tgtatgatga aaactctttc cgctgtgacg agaaaatctt 642541 cgagcttgat attcctgttt tgggaatttg ctacggcatg cagctgatga ctcattacct 642601 tggcggtaaa gttgaagcgg caagccagcg tgaatacgga aaagcaaaca tccgcatcga 642661 aggcacacct gatttgttca gagatcttcc gaatgaacaa gtggtttgga tgagccacgg 642721 cgatttggtt gtagaagttc ctgaaggctt cactgttgac gcgacaagcc atcactgccc 642781 gaactcagca atgagcaaag cggacaaaaa atggtatggc gttcagttcc acccggaagt 642841 gcgccactct gaatacggca atgatcttct gaaaaacttt gtattcggtg tttgcgaatg 642901 cgaaggcgaa tggtcaatgg agaactttat cgaaatcgaa atgcaaaaaa tccgtgaaac 642961 ggtcggagac aaacaggttc tttgcgcgct aagcggcggc gttgattcct ctgttgttgc 643021 tgttttgatt cataaagcga tcggcgacca gctgacttgt atctttgtag accatggtct 643081 tctccgtaaa ggcgaagctg agggtgttat gaaaacattc agcgaaggct ttaacatgaa 643141 tgtgattaaa gtagacgcaa aagatcgatt cttaaacaaa ctaaaaggcg tttctgatcc 643201 tgagcaaaaa cgcaaaatca tcggtaatga attcatttac gtgtttgatg atgaagcgga 643261 caagctcaaa ggcatcgact accttgcaca aggtacgctt tacacagata tcatcgagag 643321 cggtacagca acggcgcaaa cgatcaaatc tcaccacaat gtcggcggac ttcctgaaga 643381 catgcagttt gagctgatcg agccgttaaa tacgctcttc aaagacgaag tgcgcgcgct 643441 tggcacagag ctcggcattc cggatgaaat cgtatggcgt cagccgttcc caggaccggg 643501 actcggaatc cgcgttcttg gcgaagtaac agaagaaaaa cttgaaatcg ttcgtgaatc 643561 agatgcaatc ttgcgtgaag aaattgcaaa tcacggctta gagcgtgata tctggcaata 643621 cttcactgtt cttcctgaca tccgcagcgt tggtgttatg ggtgacgcaa gaacatatga 643681 ttacacaatc ggaatccgcg ccgttacatc aatcgacggc atgacatctg actgggcgcg 643741 tatcccgtgg gatgtgcttg aagtcatttc gacacgtatc gtaaacgaag tgaagcacat 643801 taaccgcgtg gtgtatgata ttacaagtaa gccgcctgcg acgattgagt gggaataaga 643861 atcaattaat ggaaaccatc tttttggcaa ttttgccggg aagatggttt tatttgttta 643921 ttacgaacaa aatccgattt tgcgcgacta ttgttcgctt tttgtattgt tttttcaaaa 643981 tgaacttggt acaatagaca cagaaatcaa ataagatgaa ttcgtataat cgcgggaata 644041 tggctcgcaa gtctctacca agctaccgta aatggcttga ctacgtaaac atttctttcg 644101 tttgatataa ataaaacacg gttatttatt caaactgaaa tccgtctgta gtcaagcgtc 644161 ccaaaatgta ttgggacgtt ttttatttgg cgttttcagg acagaataaa tagcaaagag 644221 tgaagggagt caaatagctt gaaaacgttt tttcagtttg atgagctggg caccagctat 644281 cgcaatgaaa tcattggcgg attaacgact tttttatcta tggcatatat tttgttcgtc 644341 aatccgatta cgcttgcttt ggagagcgtg aaagattttc cggaggcgct gagaattgac 644401 cagggtgcgg tctttacggc gacagcgctg gcgtctgcag caggctgtat cttaatggga 644461 ttaatagcga gatatccgat tgccatcgcg ccgggtatgg ggctgaacgc gttttttgcg 644521 ttttctgttg tccttggtat gggtatttca tggcaggcag ctttgtccgg tgtttttatt 644581 tcaggtctta ttttcgttgc tctttcttta acaggttttc gtgaaaaaat catcaacgcc 644641 attccgcctg agctgaaatt ggcagtcggt gcggggatcg gcctgtttat tacatttgtt 644701 ggattacaag gttcaggaat cattacagcg aatccttcta cgctcgtcac gatcggaaac 644761 attcacagcg gtcctgtgct gttaacgatt ttcggtgtga ttgtcacggt tattttaatg 644821 gtgcttcgcg tgaacgcagg cgtgtttatc gggatgctat taacagcggt agccggcatg 644881 attttcggtt tggttccggt tccgactcaa attatcggca gtgtgccaag ccttgcgccg 644941 actttcggac aagcgtggat tcacctcccg gatattttct ctgtacaaat gctgatcgtt 645001 attttaacat tcttgtttgt cggatttttt gatacagctg gtacacttgt tgctgtggca 645061 acacaagctg gtttaatgaa ggaaaacaaa ttgccgcgtg cgggccgtgc gcttttagct 645121 gattcatctt ctattgtgat cggtgccgtg cttggtacgt ctacaacaac ttcttacgtg 645181 gaatcaagct caggtgtcgc tgcgggtgcc cggtcaggat ttgccgcaat tgtaacaggg 645241 attctctttt tactggctac gtttttctcg ccgctcctat cagtcgttac gtcaaatgta 645301 acagcgccgg cgcttattat tgttggtgca ttgatggtgg cgccgcttgg caaaatcgct 645361 tgggataagt tcgaagtggc cgttcctgct ttccttacca tgatcatgat gccgttaacg 645421 tacagcatcg cgactggtat tgccatcgga tttattttct atccgattac aatggtgtgc 645481 aaaggaaaag caaaagaggt tcatccaatc atgtacgggc tgtttgtcgt atttatcctg 645541 tactttatct tcttaaaata aggaatgaaa aaccagctgc actggcagct ggtttttttg 645601 ttgcaaaaga taaaaccatt tcatacgata taccgtcatg tagatgtgcc gccatgcttt 645661 acttaaatgg aaatgacttg actgttcagg aaggcttcgg taccttatat aagtgtttta 645721 ttttcttgct gaatggtatt ccgccgtatt tttttgatag gagttgctga catgacggaa 645781 gaaagaaaag aaacgtttga agaagaaatt aaccagagtg aaagaataga tgcagatgaa 645841 gaaccgctat cgagaatgtc cagaaaggcg agccggcaaa gcaagcagaa gcaaaaacaa 645901 aagcagaaac cgcgccagga acgcggtgaa tcaactgtta aagacaagct tgcgtctgtt 645961 tgggcagcca tcaacagata ttgcggtttt gcgttctcga ttttaaaatc tccggcgaaa 646021 actgtcgtaa cggatggttt ttctcattat aagtacggtc tgatttcaat gcttatattc 646081 agtatcattt tttcaattgg gaattggttt cagttaaagg caagctggaa tcggccgctc 646141 ggtttcggag aacgccatca tgctttctat gacgggtttt tagttgttct tgtgtatttg 646201 ctgatctttt tcgcggtaat ggtctttgct atatgggctg tctcccgcta tatgatgaag 646261 cagaaggtga cgttcagaga agcggctgcc gtattgggtt cattgcttgt acccgtaatt 646321 gctgtttcaa tcctttggct gatctttgcg atcgtaaata tcccaatgct gacagtactg 646381 tttacggtgc tgatcttgtt ttccatcttt tttatcatcg cgctgtatgt acagcgtgtg 646441 taccaggcgg cacaagatgc accaattgat tatatctatt gtgtatttgc agtagttgcg 646501 atagcgctgc tgtttacggc agtgacttgg ccgtttattt ctgaatatat tacggcgtcg 646561 ttgattccgc tttaatgaaa aaaccggcta atcctagccg gtttttttat gtcacacttt 646621 ttacaaatat atctaaaaaa catagttgat ttgtaggatt aacccgtgta tgatggggaa 646681 aatgctgaaa acgtccagcg caaaaacctt tatgtttaag gaggatgatg gacatggctg 646741 atgtacttcg ccgagcaatt aaccaaaaga agcaattttt aaaaaccaaa ttactgctct 646801 cggaatttta tcaaggaaga ggggaacagc ttgctgacta cacgctgagt gagcttgaga 646861 aagaatacaa gtcccttcag aaaatgaaaa aagagatctg acaatagata taaagaggtg 646921 agtctgctga aaagcgggct tttttgtttt gattttgaaa aggcgagaaa gagggtaaac 646981 tactactgtt caacacataa aagcgtgtcg aaatattttg cttaagctta cgggcgaagc 647041 tgattgtaaa cggctcattt ctctagtaga atatgaatgc tttgtgcaag ctgaagagta 647101 gggggatgaa taaaatgatg caaaccatct tatcaaatgg gatagccatg gttctcataa 647161 ttctcattat taatattgtc tatgtgtcat tttttacgat aagaatgatt ttaacgctga 647221 aaggacagcg ttatttagcg gccggcatca gtacgattga aatactggtt tatgtgacag 647281 gactgagtct ggtgctcgat aacttagacc agattcaaaa tgtgatcgcg tacgcgctcg 647341 gttacggtct tggcgtaatt gtcggcatga aaatagaaga aaaattggcg cttggctata 647401 ttatggtcaa tgtgattacg aaggagctcg atcttgatct tccgaagcag ctccgtgaaa 647461 aaggctacgg cgtgacaaac tgggtggcag gcgggcttga aggcgaccgc acagcccttc 647521 agatcctgac gccgagaaga tatgaactcc agctatatga tacgattaaa acacttgatt 647581 caaaagcctt tattattgcg tacgaaccaa aaacaatcca cggcggcttc tgggtcaaag 647641 cggtgaagaa gaggagaatt aaagaataat ggcaaagccg aagaagaaaa agtttgaagt 647701 gacagagcag caaacgattg atgcggtgct tcagcaaatg aaagaagaag gatatctgcc 647761 tgtaaggcga atggaagagc ctatttttat ggaaaaaaag gaaaatgggt caattcagat 647821 cgttccgtgc gggaaaaaaa tcgtatttga agggaaattg atctaaaaca cgaacattag 647881 tagaatgaat ttttgtatcg ttcgataata tcgttgacat tatccatgtc cgttgttaag 647941 ataaacatga aatcaaaaca cgacctcata taatcttggg aatatggccc ataagtttct 648001 acccggcaac cgtaaattgc cggactatgc aggaaagtga tcgataaaac tgacatggat 648061 atatcgcaga agcgaacgac tgacgataca tgtaccatgc ccggtttgta ttgcttcctc 648121 ataagtgcaa tgcagagcgg gtatttttta ttttctgaaa acaaaagcat tagaaggtgg 648181 ggaacagaat gcagccgcta gtaggaatca tcatgggaag cacttccgat tgggagacaa 648241 tgaaacacgc atgcgacata cttgacgaac tcaatgttcc gtacgaaaaa aaggtcgttt 648301 ccgctcaccg gacgcctgat ttcatgtttg aatatgctga aactgctaga gaaagaggca 648361 tcaaggtgat tattgccggt gccggaggag cggcgcatct gccagggatg acggctgcga 648421 aaacaacact gccagtcatt ggagttccgg ttcagtccaa ggcgctgaac ggaatggatt 648481 cacttctttc catcgtccaa atgcctggag gcgtgcctgt tgcgacaaca tccatcggca 648541 aagcgggtgc tgtgaacgca ggcctgttag cggcgcaaat tttgtcagca tttgacgaag 648601 accttgcccg taagctggat gagagaagag aaaatacaaa acagacagtg ttagaaagca 648661 gtgatcagct tgtctaaaca aatcatctat ccgggagctg taatcggcat tatcggcggc 648721 ggccagcttg ggaaaatgat ggctgtgtcc gccaaacaaa tggggtataa agtcgcggtc 648781 gttgatccgg tgaaagattc gccgtgcggg caggttgcgg atgtcgaaat taccgctcat 648841 tataatgacc gtgaagcgat tcgaaaattg gctgaaatca gcgatatcat cacatatgag 648901 tttgaaaaca tcgactatga tgcgctgcat tggctaaaag atcatgcgta tctcccgcaa 648961 ggaagtgagc tgctgcttat tacccaaaac cgtgaaacag agaaaaaagc aattcaatcc 649021 gcgggctgtg aagtcgcacc gtacagcatc gtcaaaacaa agaatgaatt gaaacaggca 649081 gtacaggagc tcaggcttcc ggcagtgctg aaaacatgcc gcggcgggta cgacggcaaa 649141 ggccaatttg tgataaaaga agaggcgcaa atggagcagg cagccgctct gttagaacac 649201 ggaacttgca ttcttgaaag ctgggtttct tttaaaatgg aactgtcggt gatcgtcgtt 649261 agatcggtaa acggtgaaat ttcaacattt ccgacagctg aaaacattca ccacaacaat 649321 attcttttcc aaagcatcgt gcccgcacgg gtagagaaag ggattcagca gaaggctgct 649381 gatctcgcag ttaagcttgc agatgagctt aaccttgtcg gaccgcttgc tgttgagatg 649441 ttcctgacag aggacggaga gcttttggtc aatgaactgg cgccaagacc gcacaattca 649501 gggcattata cgctggacct ttgcgagacg agccagtttg agcagcatat cagagcggta 649561 tgcgggcttc cgcttgggaa gacagatttg ctgaagccgg gcatgatggt gaatcttctc 649621 ggcgatgaag tgaagcttgt tgaggaagac ccggagcttt taaaagaggc aaagctatat 649681 atatacggaa aacatgaaat caaaaaaggc cgcaaaatgg ggcatattac atttatgaag 649741 cagcctgaag acgaatggat tcaggagatc acaaataaat ggatgaatag agacggagga 649801 caagcagaat gatcgaacgt tattcaagac ctgaaatgtc cgcgatttgg acggatgaaa 649861 acagatttca agcatggtta gaggttgaaa ttcttgcctg tgaagcgtgg gcggagcttg 649921 gcgtcattcc gaaagaagat gtaaaggtta tgcgcgaaaa cgcgtcattt gacatcaacc 649981 gcattttaga aatcgaaaag gacacgcgcc atgacgttgt cgcttttacg cgcgctgtat 650041 ccgaatcact gggcgaagaa agaaaatggg tgcattacgg cttaacgtca actgacgttg 650101 ttgatacggc tctttcctac ttattaaaac aggcaaacga tattttgctc aaggatcttg 650161 agagatttgt tgacattata aaagaaaaag cgaaagaaca taaatacaca gtcatgatgg 650221 ggcgcacaca cggcgtacac gctgagccta caacattcgg cttaaaactt gcgctttggc 650281 atgaagaaat gaaacgtaat cttgagcgct tcaaacaagc gaaagcaggc atcgaggttg 650341 gaaagatttc cggtgctgtc ggcacatatg cgaacattga tccatttgtt gaacaatatg 650401 tctgtgagaa gctcggattg aaagcagcac cgatttccac tcaaaccctt cagcgtgacc 650461 gccatgctga ctatatggca acacttgctt tgatcgcgac aagcatcgag aaattcgctg 650521 tggaaatccg cggactgcaa aagagtgaaa cacgtgaagt agaggaattt ttcgcgaaag 650581 ggcaaaaggg ttcatctgca atgccgcata aacgaaatcc gattggctct gaaaacatga 650641 caggcatggc gcgcgtgatc cgcggctaca tgatgacagc ttacgaaaat gttccattat 650701 ggcatgagcg cgatatttct cattcttcag cagaacgaat tattcttccg gatgcgacaa 650761 ttgcgctgaa ctacatgctg aaccgcttct ccaacatcgt gaagaactta acggtcttcc 650821 cggaaaacat gaagcgcaac atggaccgca ctctcggcct tatctattct cagcgtgtgc 650881 tccttgcttt gattgacaca ggcctgactc gtgaagaagc ctatgataca gttcagccga 650941 aagcaatgga agcgtgggaa aaacaagtgc cgttccgcga gcttgtggaa gcggaagaga 651001 aaatcacgtc acgtctttct ccagaaaaaa ttgctgactg ctttgattac aattaccatc 651061 tgaaaaatgt tgatctgatc tttgaacgtt taggtttagc atagaagaag cttttagcgg 651121 cttcttctaa gccgccgcag tttgaaaatt cccaacattc gggttaggag gccttccgtg 651181 aatattgtga agaatgaact tttatacgaa ggaaaagcaa aaaagatcta caaaaccgat 651241 gacgaaaaca cgctgtatgt cgtgtataaa gactccgcca ctgcctttaa cggcgagaaa 651301 aaagcagaaa tcagcggaaa agggcgctta aataatgaaa tttcaagcct cattttcaaa 651361 caccttcatg ctaagggcat taacaatcat tttatcgagc gcatttcgga aacggagcag 651421 ctcattaaaa aggtaacgat tgtgccgctt gaagtcgtgg taagaaatgt tgtggcagga 651481 agcatgtcca aacgtctcgg cattccagaa ggcacggagc ttgagcagcc gattatcgag 651541 ttttactaca aggatgacgc gctgggtgat ccgctcatca cagaagatca tatttggctt 651601 ttgaaggcgg cgactcctga gcaggtagaa accattaagt ccattacaac aatagtaaat 651661 gaagagcttc aaagcatctt cgacgattgt catgtcagat taatagattt caagcttgaa 651721 ttcggtttag atgcagaagg gcaagtgctt ttggcggatg aaatatctcc tgacacatgc 651781 cgcttgtggg ataaagaaac gaacgaaaag ctggacaaag atttattcag acgcaatctg 651841 ggaagcttaa ccgacgcata cgaagagatt ttcaatagac tgggaggcat tcatcatgta 651901 taaagtaaaa gtttatgtca gcttaaaaga aagtgtacta gatccacaag ggagcgctgt 651961 ccagcatgcc ttgcacagta tgacttacaa cgaagttcaa gatgtgcgca tcgggaaata 652021 catggagctt accattgaaa aatctgaccg tgatcttgac gtgctagtga aagaaatgtg 652081 cgaaaaactt cttgcgaaca cagtgattga agattataga tatgaggttg aggaggtagt 652141 cgcacagtga aatttgcggt gattgtgtta cccggctcca actgtgatat cgatatgtat 652201 catgctgtaa aggatgagct cggccatgaa gtggaatacg tctggcatga ggaaacaagc 652261 cttgacggct tcgacggcgt gttaattccg ggaggatttt cttacggcga ttacttaaga 652321 tgcggcgcca tcgcccgatt tgcgaatatt atgccagctg tcaaacaagc agcggctgaa 652381 ggaaaacctg ttcttggcgt ctgtaacgga ttccagattt tacaggagct tgggctgctg 652441 ccaggcgcaa tgagacgcaa caaagatctg aagttcattt gccgtccggt tgaattgatt 652501 gttcagaacg acgaaacctt attcacagct tcctacgaaa agggagaatc gattacaatc 652561 ccggttgccc atggtgaagg gaatttctac tgtgatgacg agacgcttgc tacattaaag 652621 gaaaacaatc aaattgcttt cacatacggc tctaatatta atggaagtgt cagcgacatt 652681 gccggtgtcg tgaatgagaa aggcaatgta ttaggcatga tgcctcaccc tgagcgcgcg 652741 gtcgatgaac tgcttggaag cgccgacggt cttaaattgt tccagtctat cgtgaaaaat 652801 tggagggaaa ctcatgtcac tactgcttga accaagtaaa gaacaaataa aagaagagaa 652861 actgtatcag caaatgggtg tcagtgatga tgagtttgca ttgatagaat ccattcttgg 652921 aagattgccg aactacacag aaatcggaat tttttctgtc atgtggtctg agcattgcag 652981 ctataaaaac tcaaagccga ttctgcgtaa attcccgaca agcggcgagc gtgtgctgca 653041 ggggccgggg gaaggcgccg gaatcgttga tatcggtgat aaccaagcgg ttgtgttcaa 653101 aattgaatca cataaccacc catcagctct cgagccttac caaggcgctg cgactggcgt 653161 aggcggaatt atccgtgatg tattctcaat gggtgcacgc ccaatcgctg tattgaactc 653221 tcttcgattt ggtgaactga cttcaccccg cgtgaagtac ttgtttgaag aagtagtagc 653281 gggtatcgcc ggatacggca actgtatcgg catcccgaca gtcggcggag aagtgcagtt 653341 tgacagcagc tatgaaggaa atccgctcgt caacgcaatg tgcgtcggtt taatcaacca 653401 tgaagacatc aaaaaaggcc aggcaaaggg tgtcggcaac acagtaatgt acgtaggagc 653461 gaaaacaggg cgtgacggca tccacggcgc tacgtttgct tctgaagaaa tgtcagactc 653521 gtctgaagaa aagcgttctg ctgtccaagt cggcgatccg tttatggaga agcttttgct 653581 tgaagcatgt ctggaagtca tccaatgcga cgccttagtc ggcattcagg atatgggagc 653641 tgccggttta acaagctcaa gtgcagaaat ggcaagtaaa gccggttctg gcattgaaat 653701 gaatcttgac ctgattcctc agcgcgaaac aggcatgacc gcgtatgaaa tgatgctttc 653761 tgaatcacaa gaacggatgc ttttggttat tgagcgcgga cgtgagcagg aaatcatcga 653821 tatttttgac aagtatgatc ttgaagcggt ttctgtcgga catgtgacag atgataaaat 653881 gcttcgcctg acacataaag gagaggttgt gtgcgagctg cctgttgatg ccttggcaga 653941 agaagcaccg gtttaccata agccttctca agagcctgct tactatcgcg agtttttgga 654001 aacagacgtt ccggctccgc aaattgaaga tgcgaatgaa atgctgaagg cccttcttca 654061 gcagccgacg attgcgagta aagagtgggt ttatgatcag tatgactaca tggtgcgcac 654121 gaatacagtt gtcgctcctg ggtctgatgc tggtgttctc agaatccgcg gaacgaaaaa 654181 ggcgctggcg atgacgacag actgtaacgc gcgttatctc tatcttgatc ctgaagtcgg 654241 agggaaaatt gctgtcgctg aagcagcgcg caacatcatt tgctcaggcg cagaaccgct 654301 tgcggtgaca gataacctta acttcggaaa ccctgagaag ccggaaatct tctggcagat 654361 cgaaaaagcg gcagacggca taagcgaagc gtgcaatgtt ctcagcactc cggttatcgg 654421 cggtaacgta tcgctttata acgaatcaaa cggcacggcg atctatccga caccagttat 654481 cggcatggtc ggcctaattg aagatacagc gcacattaca acacagcatt tcaaacaagc 654541 aggagatctc gtatacgtga tcggcgaaac aaaaccagag tttgccggaa gcgagctgca 654601 aaaaatgaca gaaggccgta tttacggcaa agcgccgcaa atcgatcttg atgtagagct 654661 gtctcgtcaa aaagcactgc ttgacgcgat taaaaaaggc ttcgttcaat ctgcgcatga 654721 tgtgtctgaa ggcggcttag gcgtagcgat tgcggaaagt gtcatgacga cggaaaacct 654781 tggcgctaat gtgactgtag aaggggaagc ggcgttatta ttctctgaat ctcaatctcg 654841 cttcgtcgtt tcagtgaaaa aagaacatca agctgcgttt gaagcaactg tcaaagatgc 654901 agttcatatt ggtgaggtaa cagctgacgg aattctggcg attcaaaacc aagacggaca 654961 acaaatgatt catgcgcaaa cgaaagagct tgaacgcgta tggaaaggag ctatcccatg 655021 cttgctgaaa tcaaaggctt aaatgaagaa tgcggcgttt ttgggatttg gggacatgaa 655081 gaagccccgc aaatcacgta ttacggtctc cacagccttc agcaccgagg acaggagggt 655141 gctggcatcg tagcgactga cggtgaaaag ctgacggctc acaaaggcca aggtctgatc 655201 actgaagtat ttcaaaacgg cgaactcagc aaagtaaagg gaaaaggcgc tatcgggcac 655261 gttcggtacg caacggctgg aggcggcgga tacgaaaatg ttcagccgct cctcttccgt 655321 tcccaaaaca acggcagcct ggcgcttgct cataacggaa atcttgtcaa cgccactcag 655381 ctgaagcagc agctcgaaaa tcaagggagc atctttcaaa cctcttcgga tacagaggtt 655441 ttggctcacc tgatcaaaag aagcggacac ttcacgctga aggatcaaat taaaaactcg 655501 ctttctatgc tgaaaggcgc ctacgcgttc ctgatcatga ccgaaacaga aatgattgtc 655561 gcacttgatc caaacgggct gagaccgcta tccatcggca tgatgggcga cgcttatgtg 655621 gtcgcatcag aaacatgcgc atttgacgtc gtcggcgcaa cgtaccttcg cgaggtagag 655681 ccgggagaaa tgctgatcat taatgatgaa ggcatgaaat cagagcgttt ttccatgaat 655741 atcaatcgtt ccatttgcag catggagtac atttatttct ccagaccaga cagcaatatt 655801 gacggtatta atgtgcacag tgcccgtaaa aaccttggga aaatgctggc tcaggaatcc 655861 gcagttgaag ctgacgtcgt aaccggggtt ccggattcca gtatttcagc ggcgatcggc 655921 tatgcagagg caacaggcat tccgtatgag cttggcttaa tcaaaaaccg ttatgttggc 655981 agaacgttta ttcagccgtc ccaggctctg cgtgagcaag gcgtcagaat gaagctgtct 656041 gcggtgcgcg gggttgtaga aggcaaacgc gtcgtgatgg tggatgactc tatcgtgcga 656101 ggaacaacta gccgccggat tgtcacgatg ctaagagaag cgggtgcgac agaggtgcat 656161 gtgaaaatca gttcaccgcc gatcgctcat ccgtgctttt acggcattga cacttccaca 656221 catgaagaac tgatcgcgtc ttcgcattct gttgaagaaa tccgtcagga aatcggagcc 656281 gataccctct catttttgag tgtggaaggg ctgctgaaag gcatcggcag aaaatacgat 656341 gactcgaatt gcggacagtg tctcgcttgc tttacaggaa aatatccgac tgaaatttac 656401 caggatacag tgcttcctca cgtaaaagaa gcagtattaa ccaaataaaa cttgaaaaat 656461 gacataaagg cagcgcagtt cggctgcctt tctctttctg ccctcgttcg gggagatatt 656521 ttgaaaagcg ccttaaagga gtgaatagga tgtctgaagc atataaaaac gcaggagttg 656581 acatcgaagc cggatatgaa gctgtaaaac gaatgaaaaa acacgtggag cgcacgaaac 656641 ggcttggcgt tatgggcagc cttggcggtt ttggcggcat gtttgacctg tctgagcttt 656701 cttatcaaaa accagttctc atttcgggaa cggacggtgt cggcacaaaa ttaaagctcg 656761 ctttttccat ggataagcat gacacgattg gcgtggatgc tgttgcaatg tgtgtcaatg 656821 acgtgctggc acaaggtgca gagccgctgt ttttcctcga ttatttagcg gttggcaaag 656881 cggacccagt gaaaattgaa cagattgtac aaggtgttgc ggaaggctgt gagcagtcag 656941 gttcagcctt agtcggcggt gaaacggctg aaatgccggg gctctataca gctgatgaat 657001 acgatattgc cggtttctca gtcggagtgg cagaaaagga cgaaatcgtg actggagaaa 657061 aaattgaaga gggccatctg ttgatcggcc tcagctccag cggccttcac agcaacggct 657121 tttcccttgt cagaaaagtg cttctggatg atgcggagct ggacctcgat acaacatatg 657181 agccgtttga acgcccgctt ggcgaggaat tgcttgaacc gacaaggatt tacgtgaagc 657241 ctgtgcttgc cgcggtcaaa agcggaaaaa tcgacggcat ggcgcacgtg acaggcggag 657301 gatttattga aaatattccg cgtatgcttc cggaaggctt aagtgcggaa attgatcatg 657361 gctcatggcc gatcccgccg attttttctt tcttgcaaga gtacggcaag ctaaaggaag 657421 aagacatgtt caacgtcttt aatatgggta tcggttttgt tttggcagtc aaagaagagc 657481 atctgacaga tgtgatcgga acgcttgaaa gccatggcga aaaagcctat ttaatcgggc 657541 gtgtgaaaaa aggtgaaggc gtcacattcg gcggtgcggc actttcatga aaaagtttgc 657601 ggtatttgca tcaggaaacg gttcaaactt cgaagccatc gtcacgcgtt tgaaggagga 657661 gaactgggat gcgtcagcag cgctcctcgt ttgcgacaaa ccgcaggcga aagtcatcga 657721 acgggcggaa gcattccaca ttccatcctt cgcatttgag ccgaagtctt atgaaaacaa 657781 ggctgcattt gaacaagcca tcattgaaca gcttcgtctt cacgaggttg aattgattgc 657841 tcttgccggc tatatgaggc tgatcggtga tacgctcctt caagcatatg ggggaaaaat 657901 cattaacatt cacccatcgc ttcttccggc gtttcctgga atcgacgcag tcggacaggc 657961 gttccgggcg ggtgtgaagg tggccggaat caccgtgcat tatgtcgatg aaggaatgga 658021 tacaggtccg atcatcgctc aaaaggcaat cgaaattgat gaacatgata cattggaaac 658081 aatcgaacag cgaattcaca agcttgagca taaatggtat ccgagtgtga ttaaacagct 658141 attaggatta aataacagag gtgaaaaggc atgaccatta aacgtgcatt aatcagtgtt 658201 tcagataaaa caaatctcgt tcctttcgta aaagaactga cagagcttgg cgttgaagtc 658261 atctccacag gcggaacgaa aaagcttctt caagaaaacg gtgtggatgt gatcggaatt 658321 tctgaagtga caggctttcc tgaaattatg gacggccggt taaaaaccct acacccgaat 658381 attcacggcg gccttctggc ggttcgcggc aatgaagagc atatggcgca gatcaatgaa 658441 cacgggattc agccgattga cctcgttgtc gtcaacctct atccatttaa agaaacgatt 658501 tctaaagaag acgtcacgta tgaagaagcg atcgaaaata tcgacatcgg cggacctggc 658561 atgctgcgcg cggcatcaaa gaaccatcag gatgtcacgg ttatcgtcga tccggccgat 658621 tacagcccag tgctaaatca aatcaaagaa gaaggcagcg tatctcttca gaaaaaacgc 658681 gagctcgcgg caaaagtatt ccgtcatact gcggcatatg atgcactgat cgctgactat 658741 ctgacaaatg ttgtcggtga aaaagaacca gagcaattca ctgtgacatt tgagaaaaaa 658801 caatcgcttc gctatggaga aaacccgcat caggaagcaa ctttctatca aacagctctt 658861 cctgtcaaag gctccattgc gcaagcagaa cagcttcacg gaaaagagct ttcttacaac 658921 aacattaaag acgcggatgc tgcagttcaa atcgttcgtg aattcactga accggctgct 658981 gttgctgtga agcatatgaa cccgtgcggc gtgggaacag gaaaaacgat cgcagaagcg 659041 tttgacagag cgtttgaagc ggataaaaca tctatcttcg gcggcattat cgcgctgaac 659101 cgtgaagtgg acaaggcaac tgccgaagcg cttcacaaca ttttcttaga aatcatcatt 659161 gcgccttcat tcagccaaga agcgctcgac gtcctgactg cgaagaaaaa tctccgtctg 659221 ctgacgcttg acgtatccgc cgctgttcaa aaggaaaaac agctgacatc cgttcaaggc 659281 gggctgctga ttcaagattt agatatgcac ggcttcgatg atgctgagat tagcattccg 659341 acaaaaagag agccgaacga gcaagagtgg gaagacttga agcttgcttg gaaagtcgtg 659401 aagcatgtga aatcaaatgc gattgttctc gcgaaggaca acatgacagt cggcgtggga 659461 gcaggccaaa tgaaccgcgt cggatcggca aaaatcgcaa tcgagcaagc aggggaaaaa 659521 gcgaagggca gcgcgctcgg ttcggatgca tatttcccaa tgccagatac tgtcgaagaa 659581 gcggcaaaag cgggcgttac agccatcatt cagccaggcg gatcgatccg agatgaggat 659641 tccatcaaaa aagcggatga atacggcatt gccatggtat tcaccggcat cagacacttc 659701 aaacattaag gggatgaaaa cgacgtgaat gtattaatta tcggtaaagg cggaagagaa 659761 catacgctgg cgtggaaggc agcgcaaagc agcctcgtcg agaatgtatt tgccgctccc 659821 ggaaatgacg gcatggcagc ttccgctcag cttgtaaaca ttgaggaaag cgaccacgca 659881 gggcttgtct catttgcaaa acaaaatcag gtcggcctga ccattgtcgg ccctgaggtt 659941 cctttaattg aaggtctggt ggatgaattc gaaaaagcgg gcttacatgt gttcggtccg 660001 tcaaaagctg cggcgatcat cgaaggaagc aaacagttcg ctaaggattt aatgaagaaa 660061 tacgacattc cgaccgcaga atacgagacg tttacatcct ttgatgaggc gaaggcatat 660121 gtgcaggaaa aaggtgctcc gattgtgata aaagcagatg gacttgcagc tggaaaaggc 660181 gttactgtgg ctatgacaga ggaagaagca attgcgtgct tgcatgactt tcttgaagat 660241 gaaaagttcg gtgatgcgag cgcgtccgtt gtcattgaag aatatctttc tggtgaagaa 660301 ttttctctaa tggcctttgt caaaggggaa aaggtgtatc cgatggtgat tgcccaggat 660361 cacaagcggg cgtttgacgg agacaaaggc ccgaatacag gcggcatggg cgcctactcg 660421 ccagttccgc aaatttcgga agaaacggtc cgccatgctg tagaaacgat cgttaagccg 660481 gctgcaaaag caatggtaca agaaggccgt tccttcactg gcgttttgta cgctggattg 660541 atgcttactg aaaacggctc gaaggtcatt gaatttaatg cccgtttcgg cgatccggaa 660601 acacaggtcg tgcttccgcg catggaatct gatctggtac aggtgcttct tgatctttta 660661 gatgataagg aagttgactt aagatggaag gataccgcgg cagtgagtgt tgtgcttgca 660721 tcagaagggt atccggaaag ctatgcaaaa ggcacgccga tcggcagcct tgcagcagaa 660781 actgagcagg tcgtggtctt ccatgccgga acgaaagcag aaggtggaga gttcgttaca 660841 aacggggggc gcgtcgccaa tgtgacggct tttgatgaaa cgtttgaagc ggctagagac 660901 cgagtgtaca aagcggttga tgaaattttc aaaccgggac tctttttcag aaaagacatt 660961 ggggcacgcg ctttaaaggc tgcccaaaaa taagtgagga aaacccgcag aatagctgcg 661021 ggttttttgt tatcaaaaag cgggatggca gctagaagaa gaaagcacaa cgagcgtggt 661081 tggttttcca tgggccatcg aggtgtcaat aaaatcctca agcgtatgta ccgattcagt 661141 cacgaccttt gtcacatagc tgtacatccc cgtgatgcgg tggttttctg ctacatcagg 661201 atgcgatgtt gcaaaggcgg cgtagtgctt gcagcttttc ggctccatga gaataaaagc 661261 ggtgacatgc ttgtttagtt tttcgtaaca gatattcgcg ctgtagccgg taatcactcc 661321 tttgtcttcc agcttcctga cacgctccgc cgcgcttggc gagctgagtc cgacaagctt 661381 tcccagctca accatcgtta atctgccgtt tcgctgcaaa tgcgagagaa tctgaaggtc 661441 tgtatcgtcc atttgtctgg ctcctttaca tatttaggcg aatgaatgaa aattcctttg 661501 atcgtaaggt aatgctgttg atttaacttc attgtagcat atggatgccg tcttattttt 661561 tctataataa agccatcaat cagagagggg gcatcatgtt gccagaattg cagcgctcta 661621 ttacttggat acaagggacg gcgttaacga ttggggcggt tttaggatgc gggatattaa 661681 tcctgccgtc tgtcaccgcg gacacggccg gccccgcttc tttatttgtt tgggtgttca 661741 tgtccttctt atcctttttt cttgtcggca cgctggcccg gcttgtgaaa atagcgccta 661801 gcgcgggagg aatcacggct tatgtgcagc tggcctttca gaaaaaagcc ggggctattt 661861 tgggctggat catgttaggg tccgttccga tcggcgttcc catcatcgct ttgactggcg 661921 cgcattacgt cagttacatc acagaggcgg ccgattggca gattacattg attgctggtt 661981 gcatgctggc tatatctatt ttgcttcata tgagagggat tcaactatca gcaaacatta 662041 gtacactcgt tatatgtgtc atcgtatttc tgcttgtcac ttctattgct gtgtcattgc 662101 cacacgtcac gatagcagaa ttcaagccgt ttcttccgca tggctggtct gccgctggat 662161 ctgtttctgt tatgattttt ttctcttttg taggctggga aatgattacc ccgttggctg 662221 aggaatttca tcgtcctgaa aaagatgtcc cgctcagctt gtttttggca gcgtcttgtg 662281 tggcggggct gtatatcatg ctgtcatttg tgaccgtggg tactcattca tatggagaga 662341 atggagaaat tgcatcgctt gccatgctca tttcaaaagg agcaggagaa agcggtgtat 662401 atgtcacggt atgtttagcg ctgtttatta cattcgccac catccatgcc aatattgccg 662461 gtttttcaag aatggtgtac gcattggcga gagaggggca catacccgta ttttttggaa 662521 aactcagtgc gacaaaacgt acgcctattc gcgttttgac agcgatggcc gcagtgtttg 662581 gcttagtgct tgcagcgcat ggtctgtttc aaatcgattt gacgactctg ttgaaagggc 662641 cgagcgcggc ttttatcgca tcttacatat gtacaatggc ggcagcactg aaactgctgg 662701 gcaggagaga tataggctgg tggatggcgc tcggggcatt tgtggcgtgc gcggtgattt 662761 attcattcag cggctgggca ctgctttatc cggcagtgct ggcagctgca ggatatttct 662821 atatgaaaac aaagggtggg cataaaaaaa agcttgatca cgttttgtga tcaagctttt 662881 ccatttatcc gttttgatgc tcgttatttc cagaatcgct gtgttgaaac atgtaggtca 662941 caggacagaa gcgcaagatt cccgaacccg ctttcatggc ccccataaag atgtaaaaga 663001 gatgcattct gcaccaaggt tttttcgtaa actttgcact ggcggctgac ataatcgtca 663061 atccgcaggc gattctgaac acggcattga tgagactgat gtttggcttc aaggaaatcc 663121 gctcctttta cttaaaaaag ttttttaatc gaaccttcaa aaatttgtaa cgtttttatc 663181 gtgcgtgatg aggaaggatg tgataccatg agtctaatac atgtaaagga gagtatgtga 663241 atgtccgaac gcacctttaa ctggaaaaac aaagacatca gggcacaggt tgatgttgta 663301 gactcaaagc tgcttccaac gctcctttta cggaatgctc tcgtcttaaa tccatatgta 663361 aaacaatggc tgaaaaaaaa catttggatt tatcaggacc gcattgttta tgtgggtcat 663421 gaacttccga atagagccga agaaattcat acgattgatt gtgaaggaaa atacattgtg 663481 ccaggttata ttgaaccgca cgcacatcct tttcaaatat ataatcccca aacactggcg 663541 gaatatgtgt ctcaatacgg aacaacgaca ttcgtgaatg ataacttatt tttgcttttg 663601 caaagcggaa aaaagaaagc gcttacgatt ttgaatgaac tcaaaaagca gcctgtccag 663661 tatttttggt ggtcacgcta tgacctccag accgaggttc tgaacgagga ccacgtcctt 663721 ccatttgacg tcagaaaaca gtggattgaa catccggatg tgattcaagg cggagaaatg 663781 accggatggc ctcgcctggt agatggtgat gatttaatgc tccactgtat gcaagctaca 663841 aagaaacaga gaaaacgtat tgaagggcat tttcccggcg cttctgataa aacgcttaca 663901 aaaatgaagc tgttcggtgc ggattgtgat catgaagcga tgacaggtga tgaagtgatg 663961 agaaggctgg aactgggcta ttatgtttcc cttcggaact cttccattcg ccccgatgta 664021 agaaaaatct tgcaagagct gcatgagaag ggcttccgct attatgacca cttcttttac 664081 acgacagatg gcgcaacccc gaatttctat aaaggcggca tgacaaacga gctgattcgc 664141 attgcgttag aagaaggcgt acctgcaatc gacgcctaca atatggcatc atttaatatc 664201 gcaaagtatt accaaatgga tgattattta ggagttgtcg gaccgggcag actggcatcg 664261 ctaaacatac tggaagatcc gttaaatccg aatccagtga ctgttctgtc aaaagggacc 664321 attctgcgtg aaaacggctg tgatttgaag gcgtttacaa agacggactg gcacaaaggc 664381 ggtcttgtcc cgcttgagct ttcatatgat atgacgatgg atgacttgca gttttctatg 664441 ccgatgggcg tgaaaatgcg gaatgcggtt attatggagc catatatgat tgagatcgac 664501 aattcgatgg aacagctctc gtttgaccat gatgaaagtt atttgacgat gctcgacaga 664561 cacgggaaat ggcgcgtcaa tacgatgata aaagggtttg cctcaagcgt gcagggattt 664621 gtaagctcct ttacgacgac gggcgacatt gtcgcgattg gaaaaaataa agcggatatg 664681 ctgctcgctt tcgcccgcat gaaagaaatc ggaggaggaa ttgttttagc ggagaacgga 664741 aacattctgc atgaaatccc gcttgcgctg tgcggctgcg cctcttcgga agcgtatgaa 664801 gacgtgcttg agaaggaaca aaagctgaga gatcttttga ctgaaagagg ctatgagttt 664861 tgcgatccta tctatacgct gctctttttg caaagtacgc accttccgta tatacgcatt 664921 acgccaagag gaatattcga cgtcatgaaa aaaactgtac tctttccatc gataatgcgt 664981 taaaatataa aagagcaggg agccgacata tgaaaaaatg gatgacagtt tgcgcgctgt 665041 gtttcgtgtt ttttctgctg gtatcctgcc agcagaagga tgctgtcccg gatactgcaa 665101 agaagctgaa agctccttta acggggctaa agactgaaca gaaagtgact gaacgccgcc 665161 ctgttgctgt tgtggtgaac aatcacccga aggcgaggcc gcagtcgggt ctgtctaaag 665221 ccgacattgt catagaagcg ctagccgaag ggcaaatcac aagatttctg gccattttcc 665281 aaagccagat gcctgaaact gtcggacctg tgcggagcgc gcgggaatat ttcgtcactc 665341 tcagcaatgg ctttgacagc atatttgtcc atcacggctg gagtcccggc gccaaaaagc 665401 agctggaatc cggagctgcc gattatatga acggattgga ttttgacgga agcttatttt 665461 ggagagctga tttcagcaaa ccgccccaca attcctatac gtcttatgat tacataaaaa 665521 aggcggcaga acaaaagggt tataagctga agcaggaaac aaatccgctg ctgtttcaaa 665581 catcagatgc aaaacctgca aatgaatctt acaatgttcg ggtagattat ggaacaaata 665641 acgttacaaa tcttgtcgaa tacaactatg ataaaaaagc tgaattttat acaagaagct 665701 ctgatggtgt cataacgaca gaccgggaaa ccggaaagcc ggttgcaatg caaaatattt 665761 tcattgttga agccagccat catattattg atcaagatgg aaggcgggac atcgacttgg 665821 aatcaggagg aaaaggtctg ttgtttcagc acggaaacgt cattgaaaca gactggaaac 665881 aagtgaatgg cagaattgtg ccggtaaaag acggcaagtg gcttccgttt gtgccaggaa 665941 agacttggat caatatcgta cctgatcttg atgcggcttc cattagtaaa ggagaaggtg 666001 tgtaacgatg caaatcgata aattacgcgg caaagagctg gaccagttat ttaactcgat 666061 cttatcgctg aaagacctgg aggaatgtta ccgattcttc gatgatctat gcacaattaa 666121 cgaaattcaa tcgctggctc agcgccttga agtggcgcgc atgcttcgcg aaggaaacac 666181 gtatcataag attgaaacag aaacaggcgc ttccacggct acgatttccc gtgtgaaacg 666241 ctgcttaaat tacggaaatg acgcttatga aatggcgctt gaccgtgtga aggagacgga 666301 aacagagtct tcttccaaat aaaaaaccgc cctgccgtct ggcaagggcg gtttctttat 666361 gaaacaaatt gatggatcag gttgtcgata ttgatgatac tgccatcctc tttccgatag 666421 acaacatgct ccttggaaaa atgaatcggc gaattaatcc ctgctgcggc tgcaaggtta 666481 aatagtccct cgcgcaatga aataacgtag ttgcagacac gatgctgttt ttcctcaacg 666541 ctcagtgctt tttgcaattt cggatctgtc gtcgccacac ctgccggaca ggtgttggtg 666601 tggcagacga gagcgcggat gcagccaacg gaaaacatca tgccgcgtgc gatgttaaca 666661 aagtcagcgc cgagggctaa ggcgaccgcg attttatcag gagtcaggag ctttccggaa 666721 gcaaagattt tcagctggct gcgcaagccg tactgtttaa gaagcgtgtc cacaataggc 666781 agcgctgtca taatcggaag gccgactgta tccgcgagct cgtaaaagga agctccggta 666841 ccgccttcac ttccgtcgat cgtgataaaa tccggatgct ttccgctttt ctgcatatga 666901 gagaaaagct catgcaattc ttcaggatgc cctgcgacca gtttgatgcc gactggcttt 666961 tgtccgacat ctctaagttt ttcaataaag tcgagcattt caggagggtt tgagaattca 667021 taaaagcggt tcgggctgtc aatcgacttt ccaggttcga cattccgaat gtctgccact 667081 tcctctgata ctttggcgcc gtccacatgg ccgccgcggg ttttcgctcc ttgtgccagc 667141 tttagctcaa acgctttaat ctggtcaatc ctgctttttc ttttaaattc ctcccacgaa 667201 aattccccgt ttcttttgcg cacgccgaat aggcccggtc cgatttggca aatgatatcg 667261 gcgccgccct ttaagtgata ttcagacaat cccccttcac ctgtattcat ccaggtgccg 667321 cctgccagat ggagcccttt tgagagcgcc gtaacagccc gttctccaag agaaccgtag 667381 ctcatggcag actggccgac taagcccttc acataaaatg gcttctcgca tgtatgctcg 667441 ccaatcacct gtacatcatc aggatggaga aaatacgggt ctgccttgat atgttcggca 667501 tgctccttgc gtttgaacag attgtcagca tccattttat agatttgggt ttcaattttt 667561 ggcgtttgat ttacatgcat ttcttccctt tgttttggaa acatagcgtt acggatataa 667621 tagccaggtt tatcaaaatc tcttacagat ccaaagccca tcattctgct tttgtatttg 667681 ccggagatga cggtttgctc atattccttt cgtgaaaatg gctgctcttc attgtcattg 667741 ctgtataaat actgtctgag ctccggcccg attttttcaa ggatataccg aaaccttccg 667801 atgacgggat agttgcgaag aattgagtgc tcctgctgtt tttcatcctt tatgtagatc 667861 caggcaaaca agacgatcgg gatagcgatg atcccaatga taaatgcgat gagtgctatt 667921 atgatggttt ccatctctca gcctcccttt ttatgtaacc atttccacag tagaacactt 667981 tccaaacaat agcagaagga atctggtgaa aaatgtgtgc tcctgccgat acaggactca 668041 ccatgcaggt actgccatat gctctctttt tttatgaaaa aagaatcaaa acaccttttt 668101 cagtgaataa cgagattaac ggctttttcc gtttttccgc gctatgtgaa tttgttataa 668161 tgtttaaatg gtaacaaacg aatggaggaa cgtatgacgt gtacgatgta acggagtgga 668221 agcatgtctt taaactcgat ccaaataaag atttgcctga cgaacagctg gagattcttt 668281 gcgaatcagg aacggatgcg gtcattatcg gaggaagcga tggtgtgaca gaggataatg 668341 tcctgcggat gatgtctaag gtaagacggt ttttggtgcc gtgtgtccta gaggtatcag 668401 cgattgaagc gattgttccc ggctttgact tatattttat tccgagtgta ttaaacagca 668461 aaaacgcgga ttggattgtc ggaatgcacc agaaagccat gaaggaatac ggagaactga 668521 tgtctatgga agaaatcgtg gcggagggct actgcatcgc aaatccagat tgcaaagccg 668581 cggcactgac tgaagcggac gccgatctga atatggatga tattgtcgcc tatgcgcgtg 668641 tgtcggagct gctgcaactg ccgatttttt atttagaata cagcggcgtg cttggagaca 668701 tagaagctgt caagaaaacg aaggctgtat tggaaacgtc caccttgttt tacggcggcg 668761 gcatcaagga tgcggaaacg gccaagcagt acgcagagca tgcggacgtg atcgttgtag 668821 gcaatgcggt gtatgaagat tttgacaggg ctttgaaaac agtagcggct gtgaaaggcg 668881 agtagtaaat tgtacggatt tggtttatga tagaacgtat gttttgtata ggcgggtgaa 668941 caaattttga attatattag caatcaatta ctaagcggtt taaaccccgt tcagcaggaa 669001 gcagtcaaaa caacggacgg gcctcttttg ctgatggcgg gagcgggtag cggaaagacg 669061 cgtgtcctga cccatagaat tgcttattta atggcagaaa agcatgtggc gccgtggaac 669121 attctggcga tcacatttac aaataaagcg gcacgcgaaa tgaaagaacg tgtggaaagc 669181 atcctcggac ccggcgcgga cgatatctgg atctccacat tccacagcat gtgcgtgcgg 669241 atcttgcgca gagatatcga ccggattggg atcaaccgaa atttctccat ccttgatacg 669301 gctgaccagc tttcagtgat caaggggatt ttgaaggagc gcaatcttga tccgaagaag 669361 tttgacccga gaagcatcct cggcacgatc agcagtgcaa aaaacgaatt gaccgaaccg 669421 gaggaattct ctaaagttgc tggcggctac tacgatcagg tggtcagcga tgtatatgct 669481 gattatcaga agaagctatt gaaaaaccag tcgctcgatt tcgacgattt aattatgacg 669541 acgattaaac tgtttgacag agtgcctgaa gtgcttgaat tttatcagcg caaattccag 669601 tacatccacg ttgatgagta tcaggatacg aacagggcac aatacatgct cgttaagcag 669661 cttgccgagc gtttccagaa cctttgcgtt gtgggggatt ctgatcagtc aatctacaga 669721 tggcgcggcg cggatatcac caacattctt tcatttgaaa aagattatcc gaatgcaagc 669781 gtgattttgc tagaacaaaa ctatcgttca acgaaacgga ttttgcgcgc ggctaacgag 669841 gtcattaaaa acaactctaa ccgcaaaccg aaaaatttgt ggacggaaaa tgatgaaggc 669901 atcaagattt cctattatcg cggtgataat gagttcggtg aaggacagtt tgtggccggc 669961 aaaattcatc agcttcacag cacaggcaag cggaagctgt cggatatcgc catattatac 670021 cggacaaacg cgcagtcccg tgtgattgag gaaacgcttc tcaaagcggg cttgaactat 670081 aacattgtcg gcggcacaaa gttctatgac agaaaagaaa ttaaagacat tcttgcgtac 670141 ctgcgcctcg tatccaatcc ggatgacgat atcagtttca cgcgcattgt caatgtgccg 670201 aagcgcggag tcggcgcgac atcacttgaa aaaatcgctt cgtatgcggc cataaacggc 670261 ttgtcctttt tccaagcgat tcagcaggtt gattttatcg gcgtcagtgc caaagcggca 670321 aacgcgcttg acagctttag acagatgatt gaaaacctga ccaatatgca ggattactta 670381 tccattacag agctgacaga agaaattctt gataagacgg aatacagaga aatgctgaag 670441 gctgagaaat cgatcgaagc ccaaagccgt ttagaaaata tcgacgagtt cctgtctgtt 670501 acgaaaaact ttgaacagaa aagtgaagac aagacactcg ttgcgttcct gacagacttg 670561 gcattgatcg cagatattga tcagctcgat cagaaggagg aagagtcagg cggcaaggat 670621 gcgatcaccc tgatgacact gcacgccgcg aaaggactgg agtttccggt tgttttcttg 670681 atggggcttg aagaaggcgt cttcccgcat agccgttcac tcatggagga agcggaaatg 670741 gaagaagaac gccgccttgc gtacgttggg attacaaggg cggaacagga gctttatctg 670801 accaatgcta aaatgcgcac cttgtttggc cggacaaata tgaacccgga atctcgcttc 670861 attgctgaaa taccggatga tttattggaa aacctaaatg agaaaaaaga aacaagagcg 670921 acgtctgcga gaaaaatgca gccgagacgc ggccctgttt cacgcccggt atcctacgcc 670981 agcaaaacag gcggcgacac cttgaactgg gcagtcggag ataaggcggg ccataaaaaa 671041 tggggaacag gaactgtcgt cagcgtgaaa ggcgaaggag aagggacaga gcttgatatt 671101 gccttcccga gccctgtcgg cgtgaaacgc ctgttagcag catttgctcc tattgaaaag 671161 cagtaattga agaggaaagg aagaagcaga tggacaaaga aacagcgaag cagcgggcag 671221 aagaactgcg ccgcaccatc aacaagtata gctatgaata ttacacctta gatgaaccga 671281 gcgtcccaga tgccgaatac gacagattga tgcaggagct gatcgcgatc gaggaggagc 671341 acccagacct cagaacgcct gactctccta cgcagcgcgt cggcggagcc gtgcttgaag 671401 cgtttcagaa agtcacccac ggcacaccga tgctcagtct gggcaacgcc tttaatgctg 671461 atgatcttcg tgatttcgac cgccgtgtgc gccagtccgt cggcgacgat gtggcgtata 671521 atgtggagct gaaaatagac ggtcttgctg tttctctccg ttatgaagac ggctattttg 671581 tcagaggggc cacaagaggt gacgggacga cgggagagga tatcacggag aatctgaaga 671641 cgatccgcaa tatccccctt aaaatgaacc gtgagctgtc gatcgaagtg cgcggcgagg 671701 cgtatatgcc gaagcgttcg tttgaagcac tcaatgagga acggattaaa aatgaggaag 671761 aaccgttcgc caatccgcga aatgccgcgg cgggatctct cagacagctc gatccgaaaa 671821 ttgcagcgaa acgaaacctc gatatcttcg tctacagtat agcggagctt gacgagatgg 671881 gtgtagagac gcaaagccaa gggcttgatt ttctcgacga actcggattt aaaacgaatc 671941 aggaacgaaa aaaatgcggc agcatagaag aagtcattac gctgatcgat gagcttcagg 672001 cgaagcgcgc ggacctgccg tacgaaatag acggcattgt cattaaagtc gattctctcg 672061 atcaacagga ggagctcggt tttacggcga aaagcccgcg ctgggccatc gcgtataagt 672121 ttcctgctga agaggtcgtg acgaagcttc tcgatatcga attaaatgtc ggcagaacgg 672181 gtgtgattac gccgactgcg attcttgagc cggtaaaagt tgccggcaca acggtctcaa 672241 gagcatccct tcataacgaa gatttaatta aagagaagga cattcggatt ttggataagg 672301 ttgtcgtcaa aaaagcgggc gatatcatcc cggaagttgt gaatgtcctc gttgaccagc 672361 gcacaggaga agaaaaggaa ttcagcatgc cgacggaatg tcctgaatgc ggcagtgaac 672421 tcgtccggat cgaaggagaa gtggcgcttc gctgcattaa ccctgaatgt ccggcgcaaa 672481 tccgggaagg gcttatccat ttcgtttccc ggaatgccat gaacattgat gggctcggcg 672541 aacgagtgat cacacagctg tttgaggaaa accttgtccg caatgtggca gatttatata 672601 agctgacgaa ggaacgagtc atccagctcg agcgcatggg cgaaaagtcc actgaaaacc 672661 tgatcagctc catccaaaaa tcaaaagaaa attcgttaga gcgcctgctg tttgggcttg 672721 gcatccgttt tatcggatca aaggccgcaa agacgcttgc catgcatttt gaaagcttgg 672781 agaacctgaa aaaagcctct aaagaggaac ttctcgcggt agatgaaatc ggtgaaaaaa 672841 tggctgatgc tgtgatcacc tattttcata aagaagaaat gcttgaactc ttgaatgaac 672901 ttcaggagct gggcgtaaac acgctctaca aaggcccgaa aaaagtaaaa gcagaggaca 672961 gcgactctta ctttgctggt aaaacaattg ttctgacagg aaagctggaa gagctgtcaa 673021 gaaacgaagc caaagcgcaa atcgaagcgc tgggcggaaa gctgactgga agcgtcagca 673081 aaaacacaga cttagtcatc gccggagaag cggcgggaag caagctgaca aaagcacaag 673141 agctgaacat tgaagtgtgg aatgaagaac agttaatggg agagctaaag aaataagagg 673201 agtgttttct attgaaaaag acgttggcat tggcggcaac ggcggcagta ttaatgctgt 673261 ctgcctgctc gtcaggtttc gggggggaga aggaggaaga gattacgcaa aagacggcga 673321 aatcgtcaga aaaagcgatt gtcccgaaat ataatatctc tgactcctat tacaaaatgg 673381 tgctgccgtt taaggcaggc aaagcgcgcg gcttaacaac ggaacagctg aatacaaggc 673441 tggacattga cgaatttgaa acagggctga tgcgccttgc ccaagattct ttctcaactg 673501 acgattatct gttccaagaa ggacaatatt tagatgagga tacagtatta agctggctgg 673561 cacggaaaaa aacgggctct gatttgaaaa aagccgaaaa agaagataag aacttcaaaa 673621 atgaaggctt gaacccggcg ctcccgagtt ctggttcaac agaagaaaag aacgaaagca 673681 gcccaattta tttagcatcc atgcttgagc acgattattt agtcagaaaa gacaagaatt 673741 ctatccagct tggcggcgtc atgatcggac tggcgttaaa ctcagtgtat tactatcgtg 673801 aaaaaactgg cgacccgcaa aaagaagtgg agattaaaga cagcacgctt cgccagcagg 673861 gagaaaaaat tgcacaggag gttattaacc gcctccgcaa aaaagataac ttgaagaatg 673921 tgccgattac cgtggcgctc tacaagcagg cgtcaaaaac atcgattgtg ccggggaact 673981 tcatcgccaa aacagaggtc aaagcaggct ctactgatat ctcaaattgg gatgacatca 674041 atgaaaaata tgtattctat ccggcggata caaccacagc agaaaagtac ccggatgaca 674101 ccgaggtctt taagcggttc aaaaactcaa ttgaagaata tttcccgaac tatacaggcg 674161 ttgtcggtac agcgctgtat gaaaatgatg aaatgaagaa aatgaagatt gacataccaa 674221 tgcaattcta cggaaaaagt gaagttgtcg cgtttaccca gttcttaacg ggtgaagtga 674281 tggactacta ctctaagagc tcagttgatg tcgaagtcaa tatcacgtcc tcagacggac 674341 aggaagcggt cattatccgc aatgccggag ataaagagcc gactgttcac atttatgact 674401 gatagaaaac ccttgtgcca tattggcaca agggttttta tgttacaatt aacaggaaaa 674461 gggaaaatat tttcacttct gccgaaacac aaatcaaggg gaggtatgtt gatgctggaa 674521 atcgtgtgaa aacaatcatt atcaaatcta tagcaatgaa aggatgttag acgtgcataa 674581 agatatcaaa aaaatatttc atgaagagca ggttttggca gaagctgcag cgagatacgg 674641 tttctcaaaa gatcaggtgc gttttctggc tgatgcggaa aactatgtat atgaatgtat 674701 gaaagacaat caaccttata ttttaaagat tacccatacg attcggagat cttctgatta 674761 tatgatggga gagatggaat ggctccgtca ccttgcaata gggggaattt cagtagccaa 674821 accgctcccg tcgctgaacg gaaaagacgt agaagcagtg ccggacggaa acggcgggtc 674881 atttttattg agagtgtatg agaaagcgcc ggggcaaaaa gtggatgaat cggactggaa 674941 tgaaacgcta ttttatgagc ttggcagata cacaggcagc atgcacagcc tgacaaaaag 675001 ctacaaattg agcaatcccg ctttcaaaag acaggaatgg gatgaagagg agcaattaaa 675061 gctgagaaaa tatgtgcctg aagatcagat aaaggtgttt cagcaagccg attctttgat 675121 gaatgaactg cggaggctcc cgaaaagcca ggacaactac ggcttggtgc atgcggatct 675181 gcaccatggc aattttaact gggatcatgg caaaatcacg gcatttgatt ttgatgatat 675241 cggctacaac tggtttgtta acgatattag cattcttctc tacaatgtcc tgtggtatcc 675301 tgttgtgcca tatgatgata aagctgcgtt tacagaagaa tttatgacgc attttatgaa 675361 agggtactgg gaggaaaatg agcttgaccc tgcatggctg atgataatac ctgatttcct 675421 ccgccttcgc catatgctga tttacggatt gctgcatcag atgtttgacc ttaacacaat 675481 aggagaagag gaaaaagaaa tgctggccgg tttcagaaga gatatagaga atggcacgcc 675541 gattacagca tttgattttt cagcactggt gtagatagaa aaagccaatg ggattccagt 675601 cccattggct tttataatgt atcacacttc acgccgacta cgccttcaat ggctttaatg 675661 tcatagtaga catcggtcgt gtatctgttt ttatggacgc ggaccttcac ttccataatt 675721 ggaaaatcct tttcgcctag gtcgtcgatc cgaacggagt gtgctttgat atctcttctt 675781 ttcatttctt ttaaaatctc tgtcattttg tctttatcag aaagtgacat tctgatgcgg 675841 atgtcttttt cctgcaggcg gtcggggccg atttttctga ccacccatgg gagaaattcc 675901 acactgatca ggatgaacag aagactggca aacgcttctt tataaaaacc ggctcccgta 675961 gcaagcccga gccccgctgc cccccagatc atggccgatg tcgtcaggcc ggaaatgaca 676021 tcattgcttt ttcgcaggat gacaccggcg ccgataaacc cgacgccgga gatgatttgt 676081 gccggcagac gaagcggatc catcatgatg cggtagtatt tagggaaatg atatgccgca 676141 ttaatactga cgatcgtcag catgcatgag ctgactgcga tgacaataca ggtttttaat 676201 ccgagcggct tattttttaa ttcgcgttca agcccgatga ccatgccaat caatgtggca 676261 atgcccaatt tcaataaaat atcaggatca atataccagc tcaacagcaa acttccccct 676321 tctctatggt gtttttaaat aaatatgatt ttctcacagt atttatagca aaacaagagc 676381 acaaaagcca ccaagctgcg cttgatggct tattgcttac tttttgcgtt ttaacagctt 676441 ttccatgaca ccgaataatc ggtaagaggc ttttgcagga cgttttgtga tcatgctgac 676501 aatgatgccg gcaatcatac tgagaataaa cccagggatg atttcgtaca caccggttga 676561 ttttgccagg ccggttgtaa tccagatcaa cacggtcgca gccccgacaa tcatggcagc 676621 aagcgcgccc cattcgttca ttcgtttcca atacagactg agcagaatcg caggcccgaa 676681 agctgaaccg aagccggccc aagcgtatcc gaccaaatca agaatggtgc tgttcgggtt 676741 caatgacaag agtaccgcga taacggcaat gactaagacg gacaatcgcc cgatcatgac 676801 caattcttta tcagaagctt ttcgtctgaa aaatgaccgg tataaatcct ctgttacagc 676861 acttgctgtg accaagagct gtgaggaaat cgaactcatg atggcagcca aaatagctga 676921 caataagaac cctgtaatta atgggtggaa caagatttta gagaagataa tgaaaatcat 676981 ctccggatct tttacagcaa ctccgaattt atgggcgtat gcaacaccga ttaaacccgt 677041 cagcacggaa cctagaactg taatgatcat ccagctcatg ccgattcggc gtgcaggttt 677101 taaatcttta atgtctttaa tggccataaa tcggacgatg atatgaggct ggccgtagta 677161 gcccaacccc caggctaaat aggaaataat gctaatgacg ctcgcgcctt taaaaatatc 677221 caataaatgt ggattaacag cgtcgatttc atggaaagtc ggagcaacgc cgcccacatg 677281 ggtaaaagca acgatcggca caagcactag tgctgcaaac atgatcgcac cctgcacgaa 677341 gtcagtcaga ctgacagcaa ggaaaccgcc aaacagtgtg tataacacga caactgcggt 677401 ggtcagaaac aggcctaatt tgtaatccgc accaaaagca gattcaaaca gccgtccgcc 677461 agataccata ccggaagagg tatacaatgt gaaaaagatc atgatgatca atgcagatac 677521 gattttcagc agtgatgaag aatgctggaa tcgtttatca aagaaatcag gaattgtaat 677581 cgcatcatct gccgcttctg tataagcacg cagccttgga gccagcagca agtaatttga 677641 gtacgccccg attgtaagac ctaaagcaag ccataaggtg gacagccctg tcgcaaacat 677701 cgcgccggga acacccatca gcatccatcc gctcatatcg gccgcgccgg cagacaaagc 677761 agtaacgaat ggtccgaggc ctcttcctcc aagcatgtaa tcattgatgt cagtggtttt 677821 cttgaatgca taccagccga ttaacagcat ggcaataaag taaattccta aagatataat 677881 aatttcaata ctcacgtttt accctctctt catttctaat aatgttgcat cacctctcaa 677941 attgatggtg ccagttaagc agcctggcgt aagtgcaaaa caaaagaaat tcttttgcgg 678001 gtgcacttgg taacttaacc taacaaagta ttcccggcca ttcaagcgat gaaacattga 678061 tcataagctg gaaataccgt tgcaaaccta gaagggaata aagaataaaa cgctttcaaa 678121 aaataattaa agtaaaaata ttcagaaaaa tatttcgttt ctccttctcc tcattttagt 678181 ataaaatata tagggtattg tttcgaaaac acaggcctgt ctcaaggcgt tttgttgctt 678241 taaagggctt gtttttgata tgatcagtat tatatgactt aacggagaaa tatgtggagg 678301 tggatcatat gtcacgaatt tcaatagaag aagtaaagca cgttgcgcac cttgcaagac 678361 ttgcgattac tgaagaagaa gcaaaaatgt tcactgaaca gctcgacagt atcatttcat 678421 ttgccgagga gcttaatgag gttaacacag acaatgtgga gcctacaact cacgtgctga 678481 aaatgaaaaa tgtcatgaga gaagatgaag cgggtaaagg tcttccggtt gaggatgtca 678541 tgaaaaatgc gcctgaccat aaagacggct atattcgtgt gccatcaatt ctggactaaa 678601 ggagggacac aagaatgtca ttatttgatc ataaaatcac agaattaaaa cagctcatac 678661 ataaaaaaga gattaagatt tctgatctgg ttgatgaatc ttataaacgc atccaagcgg 678721 ttgatgataa ggtacaagcc tttttggcat tagatgaaga aagagcgcgc gcatacgcga 678781 aggagcttga tgaggcggtt gacggccgtt ctgagcacgg tcttcttttc ggtatgccga 678841 tcggcgtaaa agataatatc gtaacaaaag ggctgcgcac aacatgctcc agcaaaattc 678901 tcgaaaactt tgatccgatt tacgatgcta ctgtcgttca gcgccttcaa gacgctgaag 678961 cggtcacaat cggaaaactg aacatggacg aattcgccat ggggtcatct acagaaaact 679021 cagcttacaa gctgacgaaa aacccttgga acctggatac agttcccggc ggttcaagcg 679081 gcggatctgc agctgcggtt gctgcgggag aagttccgtt ttctcttgga tctgacacag 679141 gcggctccat ccgtcagccg gcatctttct gcggcgttgt cggattaaaa cctacatacg 679201 gacgtgtatc tcgttacggc ctggtcgcat ttgcgtcttc attggaccaa atcggaccga 679261 ttacacgtac ggttgaggat aacgcgtttt tacttcaagc gatttccggc gtagacaaaa 679321 tggactctac gagtgcaaat gtggacgtgc ctgattttct ttcttcatta actggcgaca 679381 tcaaaggact gaaaatcgcc gttccgaaag aataccttgg tgaaggtgtc ggcaaagaag 679441 cgagagaatc tgtcttggca gcgctgaaag tccttgaagg tctcggcgct acatgggaag 679501 aagtgtctct tccgcacagt aaatacgcgc ttgcgacata ttacctgctg tcatcttctg 679561 aagcgtcagc gaaccttgca cgctttgacg gcatccgcta cggctaccgc acagacaacg 679621 cggataacct gatcgacctt tacaagcaaa cgcgcgctga aggtttcgga aatgaagtca 679681 aacgccgcat catgctcgga acgtttgctt taagctcagg ctactacgat gcgtactaca 679741 aaaaagcgca aaaagtgcgt acgttgatta agaaggattt cgaggacgta tttgaaaaat 679801 atgatgttat tgttggaccg actacaccga cacctgcgtt taaaatcggt gaaaacacga 679861 aggatccgct cacaatgtac gcaaacgata tcttaacgat tccggtcaac cttgccggcg 679921 taccgggaat cagtgtgcca tgcggattag cagacggact tccgctcggc ctgcaaatca 679981 tcggaaaaca ctttgatgaa agcactgtat accgcgttgc tcatgcattt gaacaagcaa 680041 cagaccatca taaagcaaaa cctgaactgt aaggggtgaa aagaattgaa ctttgaaacg 680101 gtaatcggac ttgaagtcca cgttgagtta aaaacaaaat caaaaatttt ctcaagctct 680161 ccaacgccat tcggcgcgga ggcgaatacg cagacaagcg ttattgacct cggatatccg 680221 ggcgtcctgc ctgttctgaa caaagaagcc gttgaattcg caatgaaagc cgctatggcg 680281 ctcaactgtg agatcgcaac ggatacgaag tttgaccgca aaaactattt ctatcctgac 680341 aacccgaaag cgtatcagat ttctcaattt gataagccaa tcggcgaaaa cggctggatc 680401 gaaattgaag tcggcggcaa aacaaaacgc atcggcatca cgcgccttca tcttgaagag 680461 gatgccggaa aactgacgca tacgggcgac ggctattctc ttgttgactt caaccgtcaa 680521 ggaacgccgc ttgttgagat cgtatcagag ccggacatcc gcacgccgga agaagcgtac 680581 gcatatcttg aaaagctgaa atccatcatc caatatacag gcgtttctga ctgtaaaatg 680641 gaagaaggct cacttcgctg tgacgccaat atctctcttc gtccgatcgg ccaagaggaa 680701 ttcggcacaa aaacagaatt gaaaaacttg aactcctttg cgtttgttca aaaaggcctt 680761 gagcatgaag aaaaacgcca ggagcaggtt cttctttccg gcggcgtcat ccagcaagaa 680821 actcgccgtt atgatgaagc aacgaagaaa accattctta tgcgtgtcaa agagggatct 680881 gacgactacc gttacttccc agagccagat ctagtcgagc tctacattga tgatgaatgg 680941 aaggaacgcg taaaagcaag cattcctgag cttccggatg agcgccgcaa gcgttatatc 681001 gaagagcttg gcttgcctgc atatgacgca atggttctga cgctgacaaa agaaatggct 681061 gatttcttcg aagaaaccgt tcaaaaaggc gctgaagcta aacaagcgtc taactggctg 681121 atgggtgaag tgtcagctta cctaaacgca gaacaaaaag agcttgccga tgttgccctg 681181 acacctgaag gccttgccgg catgatcaaa ttgattgaaa aaggaaccat ttcttctaag 681241 atcgcgaaga aagtgtttaa agaattgatt gaaaaaggcg gcgacgctga gaagattgtg 681301 aaagagaaag gccttgttca gatttctgac gaaggcgtgc ttctgaagct tgtcactgag 681361 gcgcttgaca acaatcctca atcaatcgaa gactttaaaa acggaaaaga ccgcgcgatc 681421 ggcttcctag tcggacagat tatgaaagcg tccaaaggac aagccaaccc gccgatggtc 681481 aacaaaattc tgcttgaaga aattaaaaaa cgctaataaa aaagcagccc ttagaggctg 681541 ctttttttat ggtcaaattg agataaagac aagatgaggg cccgaagcct ttcaacttct 681601 ttgtcgttgg ttccggccaa attggacagc atgcctttaa taatcggctt gcgcggttta 681661 tcctgagtca attcttcctc gataacatca agtgacacgg tgatatcctc gggcagcgtg 681721 ctgttttctt tcactttctg aatgtcctca agcagctggt cttttcccgc aggcatcggg 681781 ttaaaaatgt cttttgatac aatcggattg agtgcagaac ggctcagccc ctgtacaaga 681841 tcatccagtc tctcaataat aaaggctgag atttcttctg catcgatatt aagctcaccg 681901 ttaaatacca tcacgttcat ataggaatgc acaatgcctc ttgccatgat ggacagatct 681961 gcgacatacc gctcgattcc ttcgccatag gataccagca aggcgttccg gtacagctta 682021 tccgtctcca tggttacttt gtaaaagtat tgcttgattt cttgattttc cggaatgata 682081 ttttcggtaa gcaaaagaac gataaaatct ttatgatcgc gaaaatcctc aaattgagcg 682141 ccaatttgct tttttaacac ttccttaggc ggctttccgg cgagatcttc ttctatattt 682201 ttcattttgt tcatagacat accgatataa tattcacagg cagataacag cagcgcttct 682261 ttcgatttga agtgcaaata aaaagcgccc ttcgaaatgc cgcattcact ggcgatttct 682321 tggatcgtcg tagctgcgaa tccttttttc gcaaataaac gaatgctggt ttttatgatt 682381 ctctcttttt tttcattcat gacgtgcttc cccttaatcc ttgaaaaatt tagtaaaatt 682441 ttctggtata tgagttgacg ttgttgcgtt ataacgttta gtattatata gaatgaccag 682501 tcagtcaata aaaaatgtaa tggaggatat gatgaaccac gttattaatt tcgttctgaa 682561 aaacaaattc gccgtatggc tgatgacgat tattgtaacg gcagccggct tgtatgcggg 682621 tatgaatatg aagcaagagt ctattcctga cgtgaacatg ccttacttga cgatcagcac 682681 gacatatccg ggtgcaacac caagccaagt ggctgatgaa gtgaccaaac cggttgaaca 682741 agccgtacag aacttggacg gtgtcagcgt tgtgacgtcg acgtcctatg aaaacgcatc 682801 gtcggtcatg attgaatatg attatgagaa agatatggac aaagcgaaaa cagaagcagc 682861 tgaagcgtta gaaaacgtca acctgcctga tgacgcgaag gatccggaga tttcacgcta 682921 cagcttgaac tcattcccga ttctgacgct gagcgtgtcc agtgataaag ataatctgca 682981 agagctgacg aaacaagtgg aggacagcct cgtttctaag cttgaaggca tagaaggcgt 683041 tgcgtccgtc caagtatcag gccagcaggt ggaagaggtt gaattctctt tcaaagaaga 683101 caaactgaag gaatacggcc ttgatgaaga tacagtcaag caagtgattc aaggttcaga 683161 tgtgacaact ccgcttggat tgtacacatt cggaaatgaa gaaaaatctg tcgtcgtcag 683221 cggcgatatt gaaacaatta aagatttgaa gaatatgaga atcccgacgg catctgcttc 683281 aagtgcaggc agcagcgcag catctcaagc aggtgcgcag agtgctcaag cagcccaaag 683341 cgcgcaagcg gcagcacagg tgcagcaaag cgcaagcaca gcagtgccga cggtcaagct 683401 ttctgacatt gctacaatta aagatgtgaa aaaagctgaa tccgtttcac gcacaaatgg 683461 caaagacagc atcggcatca acatcgtcaa agcaaacgat gcgaatacgg tagaggttgc 683521 cgacgatgtc aaagctgagc tgaaaaagtt caaagaagac cataaaggct tcaattacag 683581 cgcaactctc gacatggcgg agccgatcac acagtcagtt gacacgatgt taagcaaagc 683641 catcttcggt gctatttttg cgattgtgat tattctctta ttcttaagag atatcaaatc 683701 aacattaatt tctgttgttt caattccatt atcattgctg atcgcactcc ttgtgctgca 683761 gcagcttgat atcacattga atattatgac gctcggcgca atgaccgttg ccatcggacg 683821 tgtagtcgat gactccatcg ttgtgatcga gaacatttac cgccgcatga gactcaaaga 683881 tgagccgctc cgcggaaaag ccttggttcg tgaagcgacg aaggaaatgt ttaaaccgat 683941 catgtcatca acgattgtga caatcgcggt attcctgccg ctcgcacttg taggcggaca 684001 aatcggtgaa ttgtttattc catttgcctt aacgattgtt tttgcgcttg ccgcatccct 684061 agtgatttca atcacgcttg tgccgatgct cgcacacagc ctgttcaaaa aatcattaac 684121 cggtgcgccg attaaagcga aagaacacaa acctggcaga cttgcaaaca tctataaaaa 684181 agtattgaac tgggcgctga gccacaaatg gatcacgtct atcatcgcgg ttctgatgct 684241 ccttggaagc ttgttcctcg taccgttaat cggtgccagc tacctgccgt ccgaggaaga 684301 aaaaacgatg cagctcacat acagcccaga accgggtgaa acgaaaaaag aagccgaaaa 684361 tgaagctgaa aaagcggaaa aaatcctgct tgaccgcaag catgtcgata cggttcagta 684421 ttcattaggc tctggcagcc cgcttgccgg aggagattct aacggtgcgt tattctatat 684481 caaatatgaa agcgacacac ctgactttga taaagaaaaa gataacgttc tgaaggaaat 684541 ccaaaagcaa tctgaccgcg gagaatggaa gtcacaggac ttcagctctt caggcaataa 684601 taacgaatta acatactatg tgtatggcga ttctgaaaac gatattaaag acacggtcaa 684661 agacattgaa aaaatcatga aagatgaaaa ggatctgaaa aacgtaaatt caggcctttc 684721 cagcacatat gatgagtaca catttgtcgc tgaccaagaa aaactaagca agctcggttt 684781 aaccgcgtct caaatttctc aggccttaat gtcacaaaca tcgcaagaac cgctcaccac 684841 tgtgaaaaaa gacggcaaag agcttgatgt gaacattaag acagaaaaag acgagtataa 684901 gagtgtgaaa gatttagaga ataaaaagat cacttccgcg actggccagg aagtcaaaat 684961 cggcgatgtg gcaaaagtga aagaaggatc aacatcagat accgtgtcaa aacgtgacgg 685021 aaaagtctat gcagatgtca caggtgaggt tacctctgac aacgtcacag ccgtatcagc 685081 tgctatccag aagaaaatcg ataagcttga ccaccctgat aacgtatcga ttgacacagg 685141 cggcgtatca gcggatatcg ctgattcctt cacgaagctc ggtttagcga tgctggcagc 685201 aatagcgatc gtttaccttg tgctcgtgat taccttcggc ggagcactag cgccatttgc 685261 gattctgttc tcattgccgt tcacagtcat cggtgccctg gtcggacttt acgtatcagg 685321 tgaaacgatc agtctgaacg ccatgatcgg tatgctcatg ctgatcggta tcgttgtcac 685381 gaatgccatt gtcttaattg accgcgtgat tcataaggaa gcggaaggcc tgtctacgag 685441 agaagcgctc ctggaagccg gctctacacg actccgtccg atcctgatga cagccattgc 685501 gacaatcggc gccttgattc cattagccct cggcttcgaa ggcggaagcc aggtcatttc 685561 aaaaggactc ggcgtaacgg ttatcggcgg tttaatcagt tcaacgcttc tgacgctcct 685621 gatcgtgcca atcgtatatg aagtattggc gaagttccgc aagaaaaaac cgggaacgga 685681 agaagagtaa aaaacaaaaa gcctcagctc tgctgaggct ttcagcttgt tgaaaaaccc 685741 tcgcattcgt tgtcaggtct gcgcgtcggt gctcacgaat tctacattcg ctccgctcca 685801 atgctccccc ttcctagact acaagggttt tcaatcaagc tgaaagaatg ttaaggatga 685861 caaaagctca aaacaagaat cagttttgag cttttgtgcg ttttcacctg taagattatg 685921 tacattttgt tgcgattttt ttaactcata gtataattaa aggttgttag tgtaaaaatg 685981 gatcggatac tcttaagtag gatgatgaga taatgaaacg tgcacgcata atatacaatc 686041 cgacttcagg acgggagatc tttaaaaagc atcttgccca ggtcctgcaa aaatttgaac 686101 aagccggcta tgaaacctcc acccatgcga cgacatgcgc aggagacgct acacacgctg 686161 ccaaggaagc ggcattgcgt gagtttgacc tgatcattgc ggcaggcgga gacggaacga 686221 tcaacgaggt cgtcaacggg cttgcgcctt tagacaatcg tccgacactc ggtgtgattc 686281 ctgtcggcac aacgaacgac ttcgccagag cgctcggaat cccacgcgag gatattttaa 686341 aagcggcaga tacggtcatt aacggcgttg cccgcccgat tgatatcgga caggtcaacg 686401 gccagtattt tatcaatatc gccggcggag gccgtctgac ggagctgacg tacgacgtgc 686461 caagcaaact gaaaacaatg ctcggccagc ttgcttatta tttaaaagga atggaaatgc 686521 tgccttcact tcgtccgaca gaagtcgaga ttgaatatga cggcaagctg tttcaaggtg 686581 aaatcatgct gtttttggtc acgctgacaa actccgtcgg cgggttcgaa aagctcgcgc 686641 cggattccag cctgaatgac ggcatgtttg atttgatgat actaaagaaa gcaaaccttg 686701 ctgaatttat cagggtcgcc acgatggcgc ttcgcggaga acacatcaac gaccagcaca 686761 ttatttatac aaaagcgaac cgcgtgaaag tcaatgtatc agaaaagatg cagctgaacc 686821 tggacggcga gtacggcggc atgctgccgg gcgaattcgt gaatctgtac cggcacattc 686881 acgtcgtcat gccgaaggag aaagcggaac agttggatga ctaaaacttg gcttggtaag 686941 ccaagctcag aatgttgaca aaatcctaaa acagttttcg ttttaggatt ttgtcatctt 687001 ttcagcgtga ttgaaaacct ttgaagtcta ggaagggcga gcatcggagc acagcgaatg 687061 ttgaattcgt gagcaccgaa gcacaggcct gacaacgaat gcgaaggttt gcctacacgc 687121 tgaaacttgg cttgaatagg ccaagttttt ctttcgctta aaactagagg tgattataga 687181 tgaaaatgaa acccccagta gaaaaaaatg aatactacga tgtgacattt gaggatttga 687241 cacatgaagg agcgggcgtc gcaaaggtcc aaggcttccc gatctttgtg ccgaatgccc 687301 tacccgagga aaaagcccaa atcaaagtga cacgcgtcaa aaaagggttc gccttcggcc 687361 gcctgattga gctgaaggaa gaaagcccgc atagaacgga cgccccatgc ccgatttaca 687421 aacaatgcgg aggctgccag cttcagcaca tgacctacga aggccagctc ctgtttaaac 687481 agaaacaagt caaagacgtc ttagaacgca tcggcaagct ggacctttca aaagtcaccg 687541 tgcacccgac actcggcatg gaagacccgt ggaactacag aaacaaagca caggtgccgg 687601 taggagaacg ggaaggcgga ctcgtcgcgg gattctatca gcaaagaagc catgacatca 687661 tcgacatgag cgcctgcctg atccagcaat ccaaaaacga cgaagccgtt caagctgtca 687721 aagacatttg cgcaaactac ggtgtcaaag cctacaacga agaacgccac aaaggctggc 687781 tccgccacat catggtcaga tacggcgttg ttacgggcga aatgatgatc gtcttcatca 687841 caagaacaag cgacttcccg cacaaagcga agatcatcga agacatcaca gcgcaattcc 687901 cgcacgtcaa atccatcgtg caaaacatca acccaaacaa aacaaacgtc atttttggca 687961 acgaaacaaa cgtcatctgg ggcgaagaat acatctacga cctcatcgga gacgtcaaat 688021 tcgccatctc cgccagatcg ttttatcagg tcaacccaga gcaaacaaaa gtgctctacg 688081 acaaagcgct tgagtacgct gagcttcaag gggaagaaac cgtcatcgac gcttactgcg 688141 gcatcggaac gatttctctc ttcctggcaa agcaggcgaa aaaagtgtac ggtgtagaga 688201 ttgtgccgga agcaattgag gacgcgaagc gaaacgccga attaaacggc aacacaaacg 688261 cagagtttgc tgttggagaa gcggaaaccg tgattccaaa gtggtacgaa gaaggcatta 688321 cagctgatac gctggtcgtc gacccgccaa gaaaaggctg cgacgaagcc ctcctgcgga 688381 caattgtgga gatgaagccg aagcgggtag tgtatgtgtc ctgtaatcct ggcacgcttg 688441 cgagagattt gcgggtgctt gaggatggcg ggtacgtgac gcgcgaagtg cagcctgtgg 688501 atatgtttcc gcatacgaat catgtggagt gctgtgtgtt gataaaatta aaagaataaa 688561 tagtcaaaaa tctatgctga tggaactgtt ggttctctaa aacgataatt gatttcaatg 688621 gttccatttg catgtacttc tatttcatct actaacaaat gaagcatttc gggggtaagt 688681 gtaccttcct tcatgaattt atctaagctc tttttaaaat caattatttc tttttcaatc 688741 ttttgaaatt ctaggtcctt agatagttgg tgaagggtag tttcaaaatt tgaaatatct 688801 tcattggtga tatttatggc taattggtaa tcttctttag atataacacc attagcaaga 688861 gagataacta aattggattt atctctcttt ttatcgttta atttttcatt aatttcgatt 688921 atcttagatt cgattttttc tttgtacttt aacgcttttt cacttaattc tttaaaataa 688981 ttttccttac tgaatttcaa atatatctta tttaggttgg ttattacttt atcagttaaa 689041 tctatttcac ttacgtaatg atcactacat gcttttaaac catgtttatt ataacttcca 689101 caaacataac cttttcgatt ctttttaaaa tgcattgacc tcctgcaatc tttgcaaacc 689161 gcagtatttg taaagagatg tacttcagct tgaggtctcc ttctttttct agttattaaa 689221 atctcttgta caataagaaa gtcttctaaa ggtatgattg gttcgtggct tttttcaata 689281 attatttggt tttctaggtt aactgacctt cttcttttac tggtaacact cggtctatat 689341 tctctacatt gttgtagtgt cccagtatag tgaggatttt cgagaatttt tcttattgaa 689401 gatccgtgcc atttgtcagt agcgttcttt ttgcgggcaa gctgcgaggg actagtgacc 689461 ccttcgttat acaatcccct tgctattgca tcaaagcctt ttccagcaat atattctgaa 689521 aagattctaa tatttactat tttctctgcg tttgctgaat ttgagagaga tatgattgta 689581 gaacgaactc aagaaggtaa aatgttggcc aagcagaatc cggatttccg agaaggaaga 689641 cccaaaaagt tcacaaagca gcaaatcaat catgcattaa cattactaga aaatcattcg 689701 tataaacaag ttgaagatat gactgggata tcagtttcta cacttgtaag agctaaaaag 689761 aagaaagctg ctgaagctat aaatggataa atattgtgaa ttaattattc aatatcttga 689821 gaaattttta taaaagtaat caaaagttta atgggggaaa cgaaatggcg ctcattgatt 689881 tagaagataa aattgctgaa atagtgaatc gagaagatca ttcagatttc ttgtatgaat 689941 tactcggtgt atatgatgtt ccacgagcta caattacgcg cttgaaaaaa ggaaatcaaa 690001 accttacaaa acgggttggt gaagtacact taaagaataa ggtgtggttt aaggaggcta 690061 agaaaggaaa gctctttgac gcccttattg atatagaaca acaagttgaa tatctttcag 690121 ctaagccacg atatttatta gttactgact atgatggagt attagcgaaa gatacaaaaa 690181 cattagaggc tcttgatgtt aaatttgaag aacttcctca gtatttcgat ttcttccttg 690241 cttggaaagg tattgagaaa gtagagtttg aaaaggaaaa ccccgctgat attaaagcag 690301 ccgaacgttt tgcacggata tatgatgtac ttcgtaaaga aaacaatatt attgagacta 690361 atagagggtt agatttattt cttattcgtt tactgttttg ttttttcgca gaagatactg 690421 acatcttcaa acgaaatagt tttacgaatt taattaagac tttgactgaa gaagatggtt 690481 caaatctaaa taaattattt gctgatttat ttatcgtgtt agataaaaat gaacgagacg 690541 atgttccatc ttatttaaaa gagtttccgt atgtaaatgg ccagttgttt actgaaccac 690601 atacagagtt ggaattttct gccaaatcca gaaagttaat tattgagtgc ggtgaattat 690661 taaactgggc taaaatcaat cctgatatct ttggttcaat gattcaagct gttgcttctg 690721 aagaaagccg tagttattta ggtatgcact acacaagtgt ccccaatata atgaaggtta 690781 ttaaaccgct tttcctagat aaacttaatc agtctttttt agatgcatac gatgattata 690841 caaaacttga aaatcttcta acacgaatcg gcaaaattaa attctttgat cctgcatgtg 690901 gttcagggaa ctttttgatt attacctaca aagaattacg gcgtatggaa atcaatatta 690961 taaaacgact tcaagaactc ttgggagagt atctttatgt accttcagta actttatctc 691021 aattttacgg aatagagatt gaagattttg cacatgacgt tgcaaaatta tcactttgga 691081 ttgctgaaca tcaaatgaat gaagaattaa aaaatgaagt tcataatgca gtacgcccaa 691141 cgttaccact tcatacagca ggggatattc gttgtgcaaa tgctattagg gttgagtgga 691201 ctgaggtttg tcccgcacaa ggatctgaag aagtatatgt ttttggtaat ccaccgtatc 691261 ttggttcaaa aaaacaaaac aaagaacata aatctgatat gttatcaatt tttggaaaag 691321 tcaagaatgg taaaatgctt gattatattt ctgcttggtt ttactttggt gctaaatacg 691381 cttcaactac aaatgcaaaa gttgcctttg tatcaacaaa ttcagttact caaggggaac 691441 aggtttctat cttatggaat gagttattca agtttggaat tcaaatcaat tttgcctata 691501 aatcttttaa atgggcgaat aatgctaaaa ataatgctgc ggtaattgtt gtgattgtag 691561 gttttggccc gttagatacc aaagtaaaca agtatttatt tgttgatgaa acgaaaaagc 691621 tagtttctaa cattagtccc tatttaactg atggtgaaaa tattcttgtt tcttctagga 691681 cgaagccaat ttcagactta cccaaactgc attttgggaa catgcctaat gatggcggag 691741 gattactctt taccattacg gaatatacag acgcaatcaa taagtatcct gaattagttc 691801 cctattttaa aaagtttata ggttcagtag agtttattaa tggtggttta cggtattgtt 691861 tatggcttaa tgaagcaaaa tatgaaaaaa taaagtctaa tcctctaata caagaaagaa 691921 tctcaatttc aaaaaatcac agggaaaaat caacagataa aggaacgaat aaacttgcat 691981 taactccgtg gaagtttaga gatactcatg aaacaactaa ttattccatt gttgttccat 692041 ctgtgtcttc tgaaaataga ttttatattc caatgggatt agcaggtgca gatacaattt 692101 tgtcaaatct aatttatgta atttacgatg cagaaattta ccttctaggc attttgatgt 692161 cacggatgca tatgacttgg gtaaaagctg tagccggaag attaaaaact gactataggt 692221 actctgcagg tttatgttat aacactttcc ctattcctga attatcaaca agaaggaaga 692281 atgaaattga agaagcaatt cttgaaattc ttgatcttcg tgaagagcag ggtggtacat 692341 tagcagagct ttataaccct tcaacaatgc caattgaatt aaaagtagca catgaaaagt 692401 tggatggaat tgtagaaaga gcgtatcgtc aaaaacaatt tgaatctgat gaagaacgct 692461 tagaagtatt gcttaaattg tatcaagaaa tgacagaacg gtaggtgtaa ggtgtatgga 692521 aaatataatt gaaattaatt ataaccaaac tggtaaaagt aagaaaacaa atgaatacgg 692581 tatgcgtgaa atgcaggcaa gagcttttga aaaacgtaac tcacaatatc tcttagttaa 692641 agcaccgcca gcttctggga aatctagagc tttaatgttt atcggtttgg ataagctcat 692701 aaatcaaggt ttgaggaaag tgattgttgc tgtacctgaa cgctctatag gttcttcatt 692761 taaaaatacg gatttaaaaa gttatggttt ctttgaaaat tggaaagttg atcctagaaa 692821 taatttaact gttggcggag ataactctaa ggttaaatct tttgttcgtt ttatggaatc 692881 ggacgatcag gtgttaatat gtacgcactc tactttgcga tttgcgtttg aaaaaattga 692941 tgataaagca tttgataatt gtttacttgc aatagatgaa tttcaccatg tatcggcaga 693001 tgtcaattct cgattaggtg aattgttaag aagtattatt cataattcat cagcacatat 693061 tgtagcgatg actgggtcgt atttccgtgg agattctgta ccaattttat taccagaaga 693121 tgaggaatta tttgacaagg taacttattc ctattatgaa caacttgatg gatatgaata 693181 tctaaaggga tttggtatag gatatcactt ctatcaaggc cagtacacat cagctattaa 693241 tgaagtattg gatacaaata agaaaacaat cgttcatatt ccaaatgtaa actcagggga 693301 atcgacaaag gataagtacg atgaagttgg taagatactt gatatgattg gtgaagttga 693361 atatcaagat gatgatactg gaattattta tgttaagcga cattctgacg gtaaaacatt 693421 gaaaattgca gatttagtag atgaccaagt tggaagagaa aatgtcgttg cgtatttgcg 693481 taatattgaa gccctagacg atttagatat aattattgct cttggtatgg cgaaagaggg 693541 ctttgactgg ccgttttgtg aacatacttt gacagttggt tatcgtggct cacttacaga 693601 aatagtacaa ataattgggc gctgtacacg tgatagttac aataaaacct atgctcaatt 693661 taccaaccta atcgcaatgc ctgatgcaaa ggatgaagta gtgacttata cagtgaatac 693721 aatgcttaaa gctatttctg cctcactttt gatggagcag gtccttacac ctgactttaa 693781 atttaaacgt agaagaaatg aaagtgaaaa atcttctact acaggagaat tattcgttaa 693841 gggattgaaa gaaccatcaa cagaaaatgt caaaaagatt attgaaaatg atattaatga 693901 tttaaaagca aaaatcatgc aagattcaca agtccaaaaa acatttagtg gagaagtaga 693961 tcccaaagta ttgaacaaag tgttgattcc gaaagttatt caaaaagtat atccaaattt 694021 atcagatgag gaaattgagg aagttagaca gcacgttgtt ctagatacag ttatgaaagg 694081 tgctaagtct gaagttgtag gaagtaaaga atttataaga atggcagata agtttataaa 694141 cattgaggat ttagatatca atctgattga ttccatcaat ccgttccaaa aagcatttga 694201 ggttctatcg aaagaattga actcaccagt gctaaaactg attcaggaaa ctattgatgc 694261 aaaacgtatt aattttgatg aagatgaact agtattcata tggccaaagg tttaggaatt 694321 ttatcgttca actggtagaa gacctgattc aaaatctgaa gacccacttg aaaggcgtat 694381 gggtgaagct gtattataca tgcaagagct taggaggaaa cgtgaaaatg gcaagtaata 694441 gataccattc tattaatgaa atcatggaaa gtcagctgtt ttaccaaatc acaacaccac 694501 ctaagaaaac acaaaaagcc cagtatgatc ctgaagttga aaagtttttg gagattattg 694561 aattcgtcaa agaaaatggg cgagaacccc aaaaagtccc tactgattta actgaaagaa 694621 gtttagcaag tcgattaatt gggattcgga aagatcctga tcgtatggaa tatttgaaag 694681 agtatgatga aattggatta cttgaagtaa gatcgaagga actaacaatt cctaaaattt 694741 cttcaattga tgatattcta aaaagtggct tatctgcatt attaggtgat aatttaaata 694801 atgatataac taggtcaatt tttgatacaa gttcacttca aaaggttacg acaatgcctg 694861 aatacgttgc aaagcgtaaa aaaataaaag attttggaaa gtttgaagag ctattcaaga 694921 agtgccacaa ggaaattaca gagggtaaac gaaaaatttt aactttcaaa aatgaacaag 694981 acatacagtc aaatagtttt tatatattaa aaggagttct tctttatgtt gaagatgtgg 695041 gagaacgtaa aaaagcaaag ggaaaaacca atgctagact tcgatgtata tttgaaaatg 695101 gaacggaatc agatatgtta ctacgttcct tatcagcgga gttatataaa catggtagac 695161 gtgtgaccga caatgaagat acattgttgg ataatgttag agaagatgat gtttcgactg 695221 gctttattta cgtactaaaa tctttgagta cagatccgca aattagttcc attaagaatt 695281 tatataagat cggttttaca actggttcag tagaaaatag aatcaggaat gcagaaaatc 695341 aatcaactta tctttatgct ccagtagaaa ttgtaaccac atatcaagtg ttcaatatga 695401 atgctagcaa atttgagacg gcaatccatc atgcgctagc aaataataat ttggatgttt 695461 ctattttggg ggcaaatgga aagatgttag ttcctaaaga gtggttcgtt gtcacacttg 695521 aagatttaca agctgtaata gatgagattg tgatgatggt tcatctttat gactaaatta 695581 gtatattagg attttagtat taataataat tttatagtag actatgaaaa aatttgatgc 695641 cataacaata acttgttccg ctttggagtt tgtcacaatt gtagaattat gtgttgcgag 695701 tattaatagg aaggggttga gcgaccgcaa aaaaaatttt cggtgctgtc cgcaaaaggg 695761 agtttgggtg ttttgcgtta tatttggttg tgtgaaggtt agcggaaact caattcgtga 695821 agttaggatt gcggttatta cgactgagta gtttcgtcat actcttttag cagtttttct 695881 gtcttatgca tttctttgag catcggattc atgtagtcgt tagctgattc tagatatgct 695941 ctcgtcagag tgtctagttt atttctaact ttagagaggt cttcttcgaa ttttccatcc 696001 gatgattgaa ggataaattc ttttgcctct tcatatcttt ttaatatgtt tttcaccatt 696061 ggagttggat tcttttgatt tattgttttt attacagtga ttgttaaatt tatttgtttt 696121 attaattctt ttcttactgt caaggtgatg ctccttttaa atctctattc tatttgagag 696181 ttgctatatc tgtttaatgg tttgatagac tactcatctt tataatttag agcaattttt 696241 acaacttgtt ccgctgtgta atcttcattg ctccagaaaa ttaaatcact tggtgccgga 696301 taaggaacat ttttctctaa taaatcgaga tattcactga ctttctcatc atctaatgtt 696361 gggttcatta attcctttac aagaaagatc aactcttctt ttgtcagttt atccattgtt 696421 tgccctccaa tagattgtat ctccattgat tttacaaatg actttatttc ttctgataat 696481 gttataggtt gtttgcataa tgatagataa ttgtcttgag aaaagttagt ctcattatag 696541 agtttattaa ttgtatttat aacaatatat tcatatggaa aacctctaaa atatctttat 696601 tttagattgg tttataaaaa atagctcagc agagtagggc tgagccattt tttaattata 696661 gaccgaggta actaattaca aattctttat catcctcatc ttcaggcaaa ataccaaggt 696721 ttttatattc ccatattgcg attctttcat atccatctaa ttctgaggct aaaatatcat 696781 cataattata atctaattgg aattctccgc tacgatccaa tgttagtgta aggttagtcc 696841 aaacatcatc gttattattt ctgtgttcag ttcttaattc ttcaaaaagt tctcttagtt 696901 ctcttaacaa cgtcttgaaa atatccttgc ttacgttgta atggctaggt atatcttgtg 696961 aataaataat ttgattattt tctggtgttc tgaaatgaaa aagaaccatt gtggaatcat 697021 ctaatacttc tgcataaaga tatatctttg tccattcacc aggtatgatg tcattgagtt 697081 tttctccaat aagttgatac aaatcttgca tcttcctagt ttccattctt ctaaccccca 697141 ggctgatttt taatagagac gcttatttct tttctgctcc caattttgta ggttacatcg 697201 aaatatgatg gtctaagtga atccccagaa tagactggtt ctatttgaac tgctactttt 697261 ttaggtggtt ttttgcttag ggcttttgcc cactcctgct ccatctcata ccatttccca 697321 ccgctcctat taatctgaga attcatcggc acgatattgt caaactggcc tgagcctttg 697381 aattgggtgg cgattaaatg gccgccgtca tcgtcaggct ttcggtcctg gggctttcca 697441 gcattcgttt gtgcatattg gtttcgtttc gcttctccca gctgcaagtc tgctttgaca 697501 cttgtaattc taccatagtt gtcagtcgtg tacgtgtagc cttcttttgt tttgtagatg 697561 atattaggct tcagcacttt ctttctgctc catcttgcga aatgctcgcc gtatttgacg 697621 gttaccggcg gtacatgtgg cgctggagtt cgtcttccgc ttgatgacgt tccgtatggt 697681 ttcggcagga tgaccttggc gaatttttgc agtccttctt taagcgtgac cccgttgact 697741 gcgttgtaag gaacgcctgc cggcactaaa tcatgacggg gatgatacgg gagaatatcc 697801 gcaagtgtga gatctccgat ttgatttaac ttggttttga cgtgtttttt tgatacttca 697861 atgcctgtgt ttactttttg tttgatgtga tcaacggttt gttttgagac tgttatggct 697921 ttttgggctg ttgctgattt gcttgctgct gttttgactt tggtcgtcac tttggcggct 697981 gtgccagttt ttgagacggc tcctacgcct tttgtgccga caattgatgt gacaacagtg 698041 ccaaccgcat atgacaccca tcttgctctt gagtaggtgt caccattcac catgtctttt 698101 tgatacgatt cttcgattgc cgctgaaatg gcttcatacg ttttgatcgg gtgagccatc 698161 gctccggtaa tcgcttcaac ggttcctccc ggatctgtga ccatatccca caggcctacg 698221 accgcgtctt tcccggaatc ataaaggccg acggcaaccc ctttgaagcc tgcttcaagc 698281 tcacgcgtgt tttcaatttg ggtgaagtat ctctgttgtt cagctgtcag attttcatag 698341 ccgatcgttt ttgccatttc gtagaattca tcggcatctg cataatcgta gtttttcagt 698401 ctttctttca gtttctcaat ctcgcgttcc ttcgcttcct ctttcttaat cttcaagtaa 698461 gcctcagtcc gcttttcaat gtcgcctttt ttcttatgta tgtcactctc acggtacgcc 698521 ttggcgttgt agtggatggg tgtggcgttt ttgcctttac ccgttgcttc ttggagcttt 698581 tggaagtcgg atttgatgaa ttgttcgttt ggttcagaca gggcgtattc tgttttcagg 698641 tcttcgtcca aggcgtccaa tttttccagt gtttttttgc gtttgtcgtt ggcatcggcc 698701 agctcgtctt tgaaggtttc tgttgaaaac aggtcgagcg ggaggatgtc gtcgatatcg 698761 tttaggatgt ctttcatcgc ttttttctgt tcggacatga tggatttaga ttttttattg 698821 gcatttgcca gttcgtgctc caggaaggat tcttcgatgt atgcgtctga gaggcctttg 698881 tcttcggcgg ctccggcgat gctgttgaaa aatgcgattt tcatgtcgat gtagtcgatc 698941 cactggtcgg cgacgccgac gtggtcgtga tagaatgcct tgatgttgct ggcgcctttt 699001 cctgagaatt cactgtcact gagatcagcg actcctttta acgcttttct caagttgacc 699061 atttgcgttc ttagttcttt gtactctttt gcacggtctg tcgcttccga aagcagtgtt 699121 ttcgcttcaa atactttcat gaccatttcc cttcttttgt tcgctcaata tcaaaatttt 699181 accacgggtc gggataaggt gggggtgaga acgtgttttg gtggaaaaat gagtcatttg 699241 gcatgtgtct ttattcgtgg agggattgga ggaaacatgg tcgaaatgat attgattgct 699301 acacattttt tggaagtttg tattctatat tgttttttaa ggagcatgtt gatgacgaaa 699361 aaacggatta catttggttt attagtttta atggtatgtg tcatcctgtt tgttctgtat 699421 gttcagttac gcaataaaga tagtattcct gtccaatctt ccgccattca ccccgaagaa 699481 gaccgcatct tttttattta ctccaatcct ttcataaaag aaagcgtgct gctttcaacc 699541 tctacaggcg aacggtttaa caggcgtacg tttaaggtgg cggatgtgcc ttatattcaa 699601 acgaaatctt atgcatcaac agaccttgta ttattggcgg aacacgagcc tttttactac 699661 acgctggaga aggatgtgat caaagagcat ccgctgtcag atccatttgc gttttggtat 699721 gaggggaagg atgtcactat tgaggcctat aatgttgata cgacgggaaa tgagatccac 699781 ataaacgaca gaaaaacgaa aaaggaatat acccttacct tgcctccgct tgtcacaatg 699841 ggggccagtg atgagaactt tatttatatc attcaaagca tgtctattta cgtgattgac 699901 agaaaaacag aggaaatgat tgagaccctg agcttagcct catacgctga tcaattcgca 699961 gactcggagg aatttatcgt cgcgagctcg gatcataaat tgactgtgat tgaaaaaggg 700021 acatggaaga cgacatatat tgcgtatcct gaagatcttg aatatgcaga tactgtgtac 700081 tatgacaaag aaagcggcag tttttacgtg gcgtacgagg acaaagaggg tggagcgaac 700141 ttgctggaat atggggagga tttttctatt cacacataca gcttgaaatt cccttatatg 700201 gaggcgaagt ttaaggggaa tctattgtat atagttgccc aggaagagca taaaaagggc 700261 atcggcggat acgtgggtgt gtttgatatc cattctaagg agatgcttta tcagtttgat 700321 ttgcctgagg aacaggtgaa ggttcaggat tttgttgtgg ttgacaataa gtgaatacta 700381 tatgaaatag aatgacaaag acccttgcat aaagggttct tttttatgaa aaaaacaaat 700441 tgacaggatg aaaaaacaat ttcttccttc tatattgttt tcaaaatttg ggattgatag 700501 aatatgacat atctcataga gaaggaggga agccgttgag tcaagccata ccgtcttcgc 700561 gtgttggtgt taagattaat gaatggtata aaatgattcg ccagttcagt gttccggatg 700621 ctgagattct gaaagcggag gttgagcagg acattcagca gatggaagaa gatcaggatt 700681 tactgatcta ttattctctg atgtgttttc ggcaccagct gatgcttgat tatttggagc 700741 cgggaaaaac atacgggaat cgccctacag tgacagagct tcttgaaacg atcgagaccc 700801 ctcagaaaaa actcacaggt cttttgaaat actactcttt gtttttccgc ggcatgtatg 700861 aatttgacca aaaagaatat gtggaagcga tcggatatta tcgcgaggcg gagaaagaac 700921 tgccgtttgt gtcagatgat attgagaaag cggaattcca ttttaaagtg gcagaagcgt 700981 attatcacat gaagcaaacc catgtgtcga tgtatcatat tcttcaagcc ttggacattt 701041 atcaaaacca tcctctatac agcattagaa cgatacaaag cttgtttgtg atcgccggca 701101 actatgatga tttcaaacat tatgataaag cgctcccgca tttagaggcg gcgctggaat 701161 tggcaatgga cattcaaaat gacaggttta tcgccatttc tctattgaac attgcaaaca 701221 gctatgacag atcaggagac gatcagatgg ctgtagaaca tttccaaaaa gcggcgaaag 701281 taagcagaga gaaagtgcct gatctgcttc cgaaagtctt gtttggatta agctggacat 701341 tatgtaaagc gggccaaaca cagaaggcgt ttcagttcat agaggaagga ttagaccata 701401 tcacagcacg ttctcacaaa ttttataaag aattgtttct gttcttgcag gccgtgtaca 701461 aggagactgt tgatgaacga aaaattcatg atcttttaag ctatttcgaa aaaaagaacc 701521 tgcacgctta cattgaagca tgtgcccgga gtgctgccgc tgtttttgaa agcagctgtc 701581 actttgaaca agcagctgcg ttttatcgga aagtgctgaa agcccaagaa gatattctaa 701641 aaggagagtg tttatatgcc tattaagaaa aaagtgatga tgtgtctggc tgttactcta 701701 gttttcggaa gcatgtcgtt tccaaccctg acaaactccg gtggatttaa ggaatcgaca 701761 gatcgaaata cgacgtatat cgatcattcc ccttacaaac ttagtgatca gaagaaagcc 701821 cttagctagg gctttttctt gctttacgga agacgttcca ttttccacat cgcggcattc 701881 cttctatttc taacgcaaga cactcgaaac aaccaaacca tttgaggtat aatggataaa 701941 gtgaataaca gtatttagat tgatatatat gaaagagagt ggaacatcat gggccgtaag 702001 tggaacaata ttaaagagaa gaaggcgtct aaggacgcaa atacgagtcg gatttatgcg 702061 aagtttggcc gtgagattta tgtggcggcg aaacagggcg agcctgatcc ggaatccaac 702121 caggcgctga aggttgtgct tgaacgtgcg aagacttaca gcgtgccgaa aaacatcatt 702181 gaacgtgcga tcgagaaggc gaagggcgga gcggaagaga attacgatga gcttcgttat 702241 gagggcttcg ggccgaacgg atcaatgatt atcgttgatg cgctgacgaa taatgtaaac 702301 cgtacggcgc cggaagtgcg tgcggcgttc gggaaaaacg gcggaaacat gggtgtgagc 702361 ggatctgttg cttacatgtt tgacgcgacg gctgtaatcg gtgtggaagg caaaacggct 702421 gacgaagcgc ttgaaatcct gatggaagcg gatgttgatg tacgtgacat tttagaagag 702481 gatgacagcg cgatcgtgta tgccgagcct gatcaattcc atgcggtgca agaggcgttt 702541 aaaaacgcgg gtgtcgagga atttacagta gcggagctga caatgcttgc gcaaagtgaa 702601 gtaacgcttc cggatgatgc aaaggaacag tttgaaaaat tgattgatgc attagaagat 702661 ttggaagatg ttcagcaggt atatcataac gttgatttag gtgagtaagg agtgagcagg 702721 ctgttatggc ctgctttttt tgtcccggaa attgttttag ctgtatgtag gcggccgcct 702781 atacgatcta taagatattc tcatactctg gactgtaacc tatgtgaagg agagagtaaa 702841 tatgactgat acaagacata tgtatggcgg acctggtttt ggtcattatc agggctttgg 702901 tattggccac ccgggctatg gcatgcaaag cacaggctat ccgggctatg gcatgtatgg 702961 aggccacccg ggctatggca tgcaaggcta cccagatcac ggcatacatg gaggagtcgg 703021 cggctatccg ggatatggtg ggtacggcgg ttacccaagc ggcggctatg gaggctctcc 703081 gggaactgga agctatccga gcatgcacca tgaaaatgat ggccatcacc actattatca 703141 ccatcatcat gatggaaaag ataatcttca tcaccatcat caccatgttg gaaaggataa 703201 tcatcaccac catcatgatg gtcattatgg ccaccatcat caccatatgg gccactgggg 703261 aaaagacggt tataaataaa gaagatgatg ataaaaagag gacactcttg cagatcaaga 703321 gtgttttttt agcttttttc ttgactgttc agtctggaaa atggtaacat ttgtttcagg 703381 aggtgatcat tttttgggga ggaataaaga atttgatacg gcgcttgttc ttcacagggc 703441 gatagaggtt tttggagagt atggctacga aggaacgtct cttcaggatc tgctctctca 703501 tttaggcatt gcgcgccaaa gtttgtatga tacgtatgga acgaagcgtg atttgttttt 703561 gtccgctgtg aaatcgtatc ttgaagggaa aaacgctgcc gttatggaaa ggcttgaagc 703621 gccaggatct gtaaaggaag ccattcgtga tatttttcag gagggtgtca atgccctgag 703681 ggatccggaa cgggcgaagg cgtgctacat tattaacagc gcgattgaac agatcccgca 703741 tgaccctgag cttgcccggt attttgaaag acaatccaag cagcttgagg acgcttttta 703801 tcacgggctt ttaagagcga aggatcaagg agaattgaat ggcgaagata ctgatatatc 703861 tgcgcttgct cggtacctga atcagagcag gctgtcactg acatttattg caaaagtgac 703921 ggcagatatg gatcggcttc aggaccatgt tgacgtgagt ttatcagtgc ttgattaaca 703981 tgtggtaaag gattctttgc ccatgtatgt actttttgga ctgaatagtc tagaaataaa 704041 aatgaggtga tgatgaatgt tgatgaatga gtttgaaaaa gcatgtgaaa cattgagaaa 704101 gtttatggct tatatgcttg agaaggacat gaagagctgg acggagcttt gggatgagaa 704161 tgctgtattt gagtttcctt atgcgccgga gggatcacca aaaagaatag aaggaaaagc 704221 ggccatttac gattatatta aagattatcc taagcagatt catctttctt catttaccgc 704281 tccgacagtg taccgttcag cagactcgaa tacggtgatt gcggagtttc aatgtgacgg 704341 ccatgtgatt gagactggac tgccttatcg ccaaagctat atcagtgtca tcgaaacgag 704401 agacggccgc attgtgcgtt atagggatta ttggaatccg cttgttgtaa aagaggcctt 704461 tggaggatca tttttgcaaa cagaggagag tgggaaatga tgaaacagaa tccgatttta 704521 atcacgggcg ggaccggcac agtcggcagc cgaatcgcca gccgtttaat aaagctggga 704581 tacagagtgc gtattgcaag ccggaaaaag ggcgcgcttg ctgatgctga gtatgtgtat 704641 tttaattgga agtacgcctc cagttttacg cctgctctgg aacaggtaaa acagatctat 704701 cttgttgctc cggtcggtgt atttgatccg gctccctatg tgcttccctt tttaaaggaa 704761 gcaaagcgtc tcggcgcaaa gcgggtagtg atgcaaagtg cgtctgttgt ctccgagaac 704821 ggtcccgtgt ttggcgcgct tcaccaggca gtgcgcgagt ttccagaatg gacggtgctg 704881 cggccctcat actttatgca aaatttcatc aatgtccagc accgcatgtc tattcaaacg 704941 gaggggcgca tcacaacggc ttcgggtgaa ggaaaacttg ggtttattga cgctgatgac 705001 atcgcagaaa cagccgtcag ggctttgatt gatgatgttc ctcatcaaac acatcatatt 705061 ctgacaggtc ccgaggcgct gagctatgcc gaagcggcgg agatcattgg agctgcggcg 705121 ggacgccggg tggagcatgt cagcatttct cgttccgagc tgcagcataa aatggaggca 705181 ggaggtttgc ccgcggatta tgcccatttt atggcgaagc ttgatgaggc aattagccat 705241 ggtgcggaac atcgggtaac ggatacagtg aagcgtgtga cgggaaaaga acctcgttcg 705301 ctgtcagagt ttgcggctgc tcatgctgca tattggacct cattttggac tgaatagtct 705361 agaaagacct tcggcgcttc cgaaggtctt cttattgaaa aagctaagtc gtgttttagt 705421 cataatcatg cctcctgcct catacctatt aaggtcattg tttttgagaa aggaggagcc 705481 ggaatgaagg atatgcagcc gtttacgcct gtcaaatcat atacgccctt tcacagccgt 705541 tttgatccct gtccgcccat agggaagaaa tattacagaa cgccccctaa cctttatatg 705601 acctttcagc ctgagcacat ggagcagttt tcgccgatgg aggctttgag gaaaggcacc 705661 ctttggaagg atctctatga tttttatgaa aacccttatc gagggggaga cgcacatggc 705721 aaaaaaggtt gacgccgaat attatcgtca gctagagcaa atacaggctg ctgattttgt 705781 gcttgttgag ctgagtcttt atttaaatac acatcctcat gatgaagatg cgttgaagca 705841 attcaatcaa tattccggct attcaaggca cttaaaaaga cagttcgaat cctcttacgg 705901 accgcttctg cagttcggca acagccccgc gggcaaggat tgggattggg gaaaagggcc 705961 atggccgtgg caagtataag gaggaatgcc tgaatgtggg tgtatgaaaa gaagctgcaa 706021 taccctgtca aggtcagtac gtgcaacccg acgctggcga agtatttgat tgagcagtat 706081 ggcggagcgg acggcgagct ggccgcggct ctccggtatt tgaaccagcg ttatacgatt 706141 cctgataagg tcatcggcct tttaacagat atcggcacgg aggagtttgc ccatttggaa 706201 atgattgcga ccatggtcta taagttaacg aaagacgcca caccggagca gctgcgtgaa 706261 gctgggcttg gcgatcatta cgtcaatcac gacagcgcgc ttttttatca taatgcggcg 706321 ggcgtgccgt ttaccgcgag ctatatccaa gcgaagggcg atccgattgc cgatttatac 706381 gaagatattg ccgcagaaga aaaggcgcgg gcgacgtatc aatggctgat tgatatttcg 706441 gatgatcctg atttaaacga ttccctgcgt tttttgcgtg agcgtgaaat cgtacactct 706501 atgcgcttca gagaagcggt tgaaatttta aaagaagaac gggataaaaa gaagattttc 706561 taataggcag attggcctct ctttcataca cccttttaca tacagagaaa atggtctgtt 706621 tttgcagttt ggtctgcatt ataatcaagg tgtgtgtgca agcttacttt ttgattggga 706681 ggcctttatg acagctttta agattgagaa cgaaacgatt gcagatggat tttacgcgtg 706741 tccggccgtc tatgaggatg cagaatcgat taccgggttg ctcgtccgaa cagctgaatg 706801 gctccgggat cggggttcta accaatggag cggacttctc aaagggcaag atatacatga 706861 tatcacgggg tcaattgaaa agggacatgt gtttgtgttt aaaaaagatg aagagcttgc 706921 ggctgtcgtg atgctgctgc ctgcaccgag cgagtgggac cggacgcttt ggggagacga 706981 tgggcatgag gagtccattt atttacaccg cctcgcagta agccgccggt ttgcgggaca 707041 ggggcttgga gcccgcgtcc ttcagtgggc ggagacgggc atacactttc cggaaaaaac 707101 gcggatccgg cttgactgtg tcgctgatag tgacgccctg cattcctttt atcggcgtat 707161 gggatatgaa ttcatgggtg ctgatgcgtc cggatatcat ttgtttgaga aagagattac 707221 ggcagaataa gcgtcctttg cagggggctt ttttgtcttt ttctaaaagg gaggcaggcg 707281 atgtgtggtc aatattattt gtgacaggga ttgtgacggc ttgtctgttt gctggcgtat 707341 ccgtattgat gcggatgaga tttcctgaca aaagtcggcc ggaatggatg ttggccgggc 707401 tgatcgtcct tggtgtgttt gcgatctggt acagcctcgt gtatgtacgc ggctgggaag 707461 gggctgcgct cggaatgctt ggattcaatg tcattttcgg agccattgcc ggatatttga 707521 tcgataaggc catccggcgt tacaggaaaa gataaggctg ctgccgtctc tcaacaggtc 707581 gaaattttca cagaccggca ggaattttct ttcgaaagga gaaatacata ttactttaaa 707641 atgaaagcgt tttccaaagc aggaaggtga tgttgatgat acacagtgtg gcaaatgggc 707701 tgaatcattt ttgtacgtgg gtgatgagac tggcctattt gaatgtgctt tggattttgt 707761 tttctcttgc aggcctggtt gtatttgggc tgatgcccgc tactgccgcg atgtttacag 707821 tggcgagaga atgggcgaag gggaatacag atgccccggt gttttctgtc ttttttcgga 707881 cgtttaaaaa ggaatggcgg gcatcacaga tcctcgggct tatcgttgtg acggctgccc 707941 tgtttctgtt tgcggatatg cggatagcgg ctcagatgga ccagcctgtg ctcgtcaatg 708001 tattcgtgag cattagtttg attttcgcgt ttgttgtgct gtatgtgttc ccggtatttt 708061 ctcattttga cgtaaaaatc agagaggtgc tgagcatcag ctttttcatt gccttcagtc 708121 gtccggcggt gacgcttttg atggcagcgg gcgctgtcgg tgtgctttgt ctcgttctgt 708181 ttcatgtcac gtttctattg tttttcagcg ggagtttact cagcctgatc ttaacgaagc 708241 tgtcctttaa agcgtttcgg tcaatggatc agcggcagga gaaagaaaag gcggcatgaa 708301 gaaaagagtt gctggctggt acaggcggat gaagattaag gataagctgt ttgtgtttct 708361 atcgttgatt atggccgtat cctttctgtt tgtatacagc ggggtccagt atgcctttca 708421 tgtgtatgat gagcagattt accgcaagtc ctcggaggtg cttcggatgt cttctgaaag 708481 gatcgaagac gagctgaaga agatagagga tgtgtcatat gaaatcatta cagacgaaca 708541 gattcagcgc atcctgagca tgcaaaatcg ggatgatacg tatgatcaat atcaaatgaa 708601 gcaggagctg tgggatcagc ttgcgggata tgccagcgat gaaaagtaca tcgattccat 708661 tcatgtgatt gatgcccgcg gctcagagta ttcagccgga agcagttctt cagatctttt 708721 gcagcaggag caggaagagg tatttaagcg agcgaaagcg aaaagtggaa gaaatctttg 708781 gatgacgctc ggcgggtcag accccgtcct gatttcagca cggcagatca ggtcctatca 708841 ccagctgagt ctgaacggct tgggcatggt actgatccag gtcaatgtaa aacagatgat 708901 tcgtgatgtg ccgaaggatt ggggcgattc agtcggagac attatgattg ctgaccaagg 708961 cggtaatttg gtgtatacgg cacatgcatc agcgcatgtt cctgaggcag caaaagagac 709021 gttgaagcac cccggttatg acttgataaa aaagaatggc aaacgttact ttatttctta 709081 tcttcaatca tcctaccaaa attggagcta ctataacgtt atcccctttg atcagatgtt 709141 cgcaaaaatt tcctttatga aaacagtgat cggcacatgc tttcttctct ttttctgtgt 709201 ggttttgctt ttcggaagga aaatcgccaa cagcatcacg gagccgattg aacagcttgt 709261 gaccgcgatg aaatcggtac agcacagcgg cattgaagca ggtgtgtcgc tttctctgcc 709321 ggaacataca caggatgagg ccggcatgct gaaccgccat tttactgtca tgatgaaacg 709381 gattaatgag ctgatggaag aaaatgtgga aaaacagctc atcattaaag aaaccgaatt 709441 gaaagcactg caagcccaga tcaatccgca ttttttatat aacacgctcg agtccatcaa 709501 ttggctggcc aaggcgaatc agcaaaagca aatctcaaaa atggtggaat cgctcggttt 709561 tcttctgcga aacagcatac atatgaagaa ggatatcgtg accattcagg aggaggcgga 709621 cattgtacgt cactatatga ccattcagcg atttcgattt gaagagcgcc tgaaattcac 709681 gttggatatt gacgatgagg tgaagcattg cctcattccg aaactgacgc tccagccgct 709741 tgcggaaaat gcgattcaat acgcgcttga accctttaca aggccatgcg ccatccggat 709801 tcaggcgaaa aaggcgaagg gctgtgtctg tattacggtc gaagataacg gccctggcat 709861 ggatggacgg attcttgaat caacgggtgg aagaggaatc ggactttgga atattcgcga 709921 gcgcatcagc ctgacattcg gagagccata cggattgcgg attcatagtg agcatgaaaa 709981 ggggacgagg attgtgatca caataccgtg ccgaaatgag gtggtgtgat gtataaaata 710041 ctgctggctg atgatgagag gattatcctt gatggaatgg cgggaatcat tgagtgggag 710101 tcgcttggcg cctcattgat cggaaaagcg cagaacggac atgaagcata tgaaaagatt 710161 gtacataagc agccgcatat cgtcatcaca gacgtcaaaa tgcccggcat ggacgggctt 710221 gagctgatca aaaaggtgtc agccgtcagc ccgtcggtgc aatttatcgt cctgtccggg 710281 tttggagagt ttgagtacgc aaaggaagcc atgaaatatg gggtgaagca ttatttgctg 710341 aaaccctgca atgaacagca gattatcagc tcgctggagg aaatcattgc tgagctgaag 710401 cggcaagatg tgcacaaaaa gaaaacagcc catctgaaac acgagctgga ccatatccgt 710461 tcctttgcag ccgatcaata cttggaaggc ttgatcgccg gtgtggccca gctttctccg 710521 ccgccttcac ttgccggaaa aaagatccgc ctcttgatct taaaagggga acaatctatt 710581 gatgctgcag ccagagaggc actcggatcg gcactgacag cggtttgcag cagcggtgaa 710641 tggaccgtgc tcgccgtaga ggagaacgcc gctgaaaagg tggcggaggt ttttgcggac 710701 cgcaagatgg ccatcagtca ggcgggagaa ctccggcacg cggggcagct gtttcgtgac 710761 acagctgaag cgtctggtga cctgcatggg agcgcagtga tttcaaaaat gatcaggctt 710821 attgccgacg agctcggaaa tccgaatctg tccttaaaat gggcggcgaa ggatatgctg 710881 tttatgaatc ctgattatct cgggaagtta tttaagcagg aaacaggcga gaaattttcc 710941 caatatgtta cacgggtgcg tcttgagcat gcgatgaagc agatgaaaat aaggagggac 711001 gtgagcgttt cagaaattgc tgaagaaatc gggtttggcg ataatccgaa gtatttcagt 711061 cttgttttta aaaaatatac cggtctgaca ccgtcagaat tcagaagaaa acagggaggc 711121 gcttccgcag gatagccatc tctgtttttt tgactttcgc cactgttttt tgagtgtttc 711181 gccctatccg aacgctttaa aataaaatgt aagcacttac attaaagggg ggattggttt 711241 gaagaagatt tgttacgtgc tgttatccct tgtctgcgtc tttttgttca gcggatgttc 711301 agcgggtgaa gaggcctcgg gaaaaaaaga agatgttaca ctcagaatcg cgtggtgggg 711361 cgggcagcca aggcatgatt atacaactaa ggtaattgaa ctatacgaga aaaagaatcc 711421 gcacgtccat attgaagcgg aatttgcgaa ctgggatgac tactggaaaa agcttgcgcc 711481 catgtctgcc gccggccagc ttcctgatgt cattcaaatg gataccgctt acttagccca 711541 atacggaaag aagaaccagc tggaagattt aacgccgtat acaaaggatg gaacgattga 711601 cgtcagttca atcgacgaga atatgctgtc gggcggaaaa atcgacaata agctttatgg 711661 atttacgcta ggtgtcaacg tgctgtctgt gattgccaat gaagatttgc tgaaaaaagc 711721 cggtgtgtct atcaatcagg aaaactggac gtgggaggat tacgagaagc tggcgtatga 711781 tcttcaggaa aaagccggtg tctacggttc caacggaatg catccgcctg atattttctt 711841 cccttattat ttgcgcacaa agggtgagcg cttttataaa gaagacggca ctggcctcgc 711901 gtatcaagat gatcagctgt ttgtcgatta ctttgaacgg cagctgaggc tagtgaaagc 711961 gaaaacgtcc ccaacacctg atgaaagcgc acagattaaa gggatggaag acgattttat 712021 cgtcaaaggc aaatcagcga ttacatggaa ctactccaat caatatttgg gctttgcccg 712081 gctgacagac tcgccgctgt ctctctatct gccgccggag caaatgcagg aaaaggcgct 712141 gacactgaag cccagtatgc tgttttccat tccgaaaagc tctgagcata aaaaagaggc 712201 agcgaaattt attaatttct tcgtgaataa tgaggaagcg aaccagctga ttaaaggcga 712261 gcgaggcgtt ccagtctccg acaaggtggc ggatgcgatt aaaccgaagc tgaatgagga 712321 agaaaccaac atcgtggagt atgtagaaac cgcgtcaaaa aacatcagca aagccgatcc 712381 gccagagcct gtgggaagcg cggaggtcat caagctgctg aaagatacgt cagatcagat 712441 tctgtatcag aaggtatcgc cggaaaaagc cgccaaaacg ttccggaaaa aggccaatga 712501 gatattagag aggaataatt gacgggaaat ggggctgacg caatgaaaaa aagccggagt 712561 ataagaaaag acaatctggc gggatatgct tttatttctc cgtttatcat cgggttccta 712621 tgctttacgg tgattccgat gggggcgtcc ctgtttctgt ccttcacgag ctatgacttg 712681 tttacggcgc cgaaatggat cgggctcgac aactttaagg aaatgtttac gggtgacgaa 712741 aagtattggc agtctctgaa ggtgacgttt acgtatgtgc ttgccggggt tccgctccgc 712801 ctcggcttcg cgctttttat cgctgtcatt ttaaacaatg cagcaaaagg aacggccatt 712861 tacagaacgc tcttttatct gccttcgatc atcggcggga gcgtcgccgt ggcgattatg 712921 tggcgcaata tttttggcaa tgacggggtc atcaatgcgc tgctgttttt tgtcgggatt 712981 gatcaaaaaa ttctttggta ccagaatccg acaagtgcgc tgtggacatt gattctgctg 713041 tccgtctggc agttcgggtc gtcaatgctg atttttttgg ccgggctgaa aaacattccg 713101 tcttcgtatt tggaagcggc aagtgtggat ggggcaaatc gggtgcagcg tttcttcaag 713161 atcacgcttc cgatccttac accgattatt ttctttaacc tagtgatgca gacgatttct 713221 gcttttatga catttacacc tgcctatatc atttcgaagg gcgagggcgg gccgcttgac 713281 gggacacttc tctattcgct ctatttgttc cagcgtgcgt ttaactattt tcaaatgggc 713341 tacgcatcgg cgatggcgtg ggtcatgctt gtcattgtcg ggctgattac gctcatattg 713401 tttaaaacat cgtcatattg ggttcattac gagtcaaagg aggaatgacg gatggagccg 713461 gtcaaccagc ctgtcagaga agccccggtt tttgagagaa aaaaagccgg gcgcgtcagt 713521 cccaaacgca tactgttcca tgtttttacg gcaacgctgg cggtgttgct gctgtacccg 713581 gttatttggc tgtttgtcag ctcgtttaaa gaaagcgcca gtatttttac aacctcacat 713641 tctctcattc cagacccttt tattctcagt aactatgctg aagggtggaa gggcattgcg 713701 ggacagccgt ttctgacgtt tattaaaaac tcggcgatta ttgtcgggct gtcaacaatc 713761 ggtgccgtca tgtcatcggc tgtcattgcg tacggatttg cgcgtatacc gtttaaggga 713821 aaaaaatttt ggtttgcgtg catgatgggg acgttaatgc tgcctcatga agtgttgatg 713881 attccgcagt atattatgtt tgcgaaatta gactggctga attcctttaa accaattgtc 713941 gttccgcaat ttttcgggca tgcgtttttt atctttctga tgatccagtt tatccggacg 714001 attcccgagg agctggatga agccgcgcga atcgacggat gcggacgctt tgcctgcttt 714061 tggcggatca ttctcccgct gattgccccc gcgcttgcga cgtctgcgat tttctccttc 714121 tattggaagt gggaggagct gattcagccg ctcttgtatt tgaataagcc ggagctttac 714181 cctgtttcac ttgcgctgaa gctttttctc gatacagagt cggcttcgaa ctggggcgcg 714241 atgtttgcca tgtcagccgt ctcgttattg cctgtgattc ttgttttctt tttgtttcag 714301 aaatatatcg ttcagggcat cagtacgacc ggattaaaat aaaaaggagt gttgcagatg 714361 gcacagctta tctttgatga agaaaaggtg acgtcggtta ttgaccggat cgtgaaacgg 714421 acatttcaga tggattttgc gtgggattgg ccgggcggcg ttgcgtttta cggtgtggcg 714481 gaggcctatg aagcgacgga aaacgaggaa tatatcaatc tgttaaaaac gtgggtggat 714541 gaacagctgg aggatgggct gccgccgctt tcgatcaacg gagtttccat tgggcatacg 714601 cttttgttcc tccacaaggt gacaggtgat gacgtgtatt tggaaacagc ggccgagatg 714661 gcggaatatg tgctgcataa ggcgccgcgc tttggcgagg gtatccttca gcatacggtg 714721 aatgcggcag aatacgtatt ccctgaacag gcatgggcgg atacgctgat gatggctggg 714781 ctgtttatgc tgagaatcgg gcgggtcatg gagcgtgagg attattttga agacggcctg 714841 cgccagtttc acggacatga ggatgtgctt caggaccctg tcacgaattt gtactaccac 714901 gcctgggaca acaaagcgca aaatcatctg tcggggattt attggggcag ggcgaacggc 714961 tgggcggcac tcacgatggc aaaggcgctc ccgcttattg aggtgacaca tccttccttt 715021 atgatcatcg acggatcgct cagagaccag ctgagcgcgc ttgtccggct tcaggatgaa 715081 tcagggctgt ggcatacaat tttggatgat ccggattctt atctggaggt ttcggcatca 715141 gcgggtattg cttctgctct gatgtcgagc ggaaagctgt atacaaaata tgtgcagaaa 715201 tcgcttgccg ccattttgga tgcagtggaa gaggacggac gggtcagcag ggtatcggcc 715261 gggacagccg tcatgaaaaa tgccgaagga tacaaacagg tgccttacaa acgaatacaa 715321 ggatgggggc agggacttgc gctgacgttt cttgctgatg ttttgaaaac gaaaaaacgc 715381 ttgtatcagt aaagatagcg gcggggggag agggatgaaa aaacagcctc aacagaagga 715441 acgggtttct cgctggaagg gaacgtattt caaaagaaac tttgtcttca ttttgctgat 715501 tgcctgtatt cccggattgc tgactggcgg cgcaatctac tttctttcga tcgacaaggt 715561 ggagaaagag ctgcagagat cgcatgaaac acaggtggcg cgtgaggtca gccgaatgga 715621 tgagaagctg ggagtgcttg aactggcact cacccagatg gcctacgatt cttcactgat 715681 gaacggattg gccgagaggg atttggagaa agactttacg ttctcctatc aattaacgaa 715741 aaagctgttt cttttgcggg atcagcagcc gctgatcgag caggcttcca tctttctgaa 715801 cagcccccgg ccacttgtgc tgagccctga atacagcgct ttgacagaac aggaggcgct 715861 tcgcaagtat cgctcgctgc ttgcctcaga ccacagcatt tattggaaac ggtcgggaaa 715921 ccaagcgatg ctgatccagc tcattccggg cgcggcggag aaaccgttcg gcgcgatcat 715981 gctggcggtt gatccgaaag aaatggaatc aatcctgcaa agcttgtccc cctatcctga 716041 tggcagtgcg ttgcttttag atcaaaatcg agaggtgctg tttcatgagg gggaaaaaga 716101 ttttgaaaag actttacttc atgagataaa aaaacagcct gctgagaacg gccattttca 716161 gatggaatgg aaaggcaagg tgtattctgt ctcctttgga gaaatgaacc ggatgcatca 716221 gcaatggacc tttgtgtcag cggcgcctct ttcagctatt acagcgccga tggtgttttt 716281 atcaaaagtg atcatcgtga tgctggtcat ttgcatcggt ttggcggtgt gcatgacatg 716341 gtatgcatca aaaaaaatct atcgtcccat ccagcatttg cttggcttgt ttaccggagg 716401 agagaagaaa acatggcagg cgtccgggca ggatgaattc aaatggattg aaaagagatg 716461 gcaggatcta tcccttgaaa gccggaagct ccaacagcag ctcctgcggc agacgcccca 716521 tatgaaaaag agttttttgc agcatctctt acagagcgat ttttactatg acaacgagga 716581 aagcctcaga tttcggatgg aggaggctgg ctggaacatc ggcggaaacg tgtttcatgt 716641 gcttgatcta caggtgacag ggctccgctg tgaaaaaagc atcttccgtg aaggtgatga 716701 acagcttgcc gtgtttacac tgactaatat cgctgaggaa ttggcggcta aacgcgtttt 716761 tcagctctcc atacttgata tcggccggct ttctgtcacc gttcttgtga tgaaaacaaa 716821 cagctctgat ctgaaggcgt atataacgga gctggcacgc caatttggag atgtaaccgg 716881 actatgcctg acctcgacat tgagcagcaa gacggagcgt gtcacggaaa ttccttcttt 716941 atttcaggat gtgaaatgcg gcaaatcccg caggaagttt gctaaccggg atcaggtcat 717001 tgatttgcag gccgacttcc ctcgggatga gcagttcgct ccttattacc cttttgagct 717061 ggaaaaacaa attgttcaga ccatccggct ggaaagaaaa caggaagcca aggaactgat 717121 agatggatgt atgaaggaac tgtcggaaaa agcggccata gacaggcatg tgcattccgc 717181 cctgattcag ctgttttccc gcattcagga ggatattttg cattccgggc tcaatcccag 717241 cgaactgttt cagcaccgga atccgtttct tgatatttca gaattgcgcg aacctaacga 717301 agcggcggcc tggctgatgg atgtagtggt gacgccttac ctttccaagc ttgagggcag 717361 aaaaaacaga cagcaaaagc agctggcaga acgtgtgatt gcgatgattc acgaacagta 717421 tatggcggac atttcattgg aaagctgtgc cgatgcgctt ggcatgaatt cctatacgtt 717481 aagcaaggca tttaagcaag tgaccggcat taattttatc gattatgtga cccagatcag 717541 aatcgaaaag gcgaaagaac tgctggtcaa tacgaataaa aaaattcatg atgtgtctga 717601 agaagtcggc tatcgccaca attatttcaa tcggattttt aaaaaacagg tcggcatgcc 717661 gccgggtgtc ttcaggcaaa tgtatcagga aacgccgtga aaggagagaa catgtgatga 717721 agaaaccgat tcaagtattt ttagcggggg attccactgt gagtgactgc ccgcctcatg 717781 aagcgccgat ggcggggtgg gggcaggtat tcgggcaatt gttttctgaa ggtgtgctgg 717841 tccgcaatca tgccaaagga ggagcgagca ccaattcttt tgtggaggaa ggaaggcttc 717901 aagcaattgc cgagcacatc acacaaggcg attatttgtt gattcaattc ggccacaatg 717961 accaaaaacc gcgggggacg aagccgtact ccacatttca gcagtttctt accttgtttg 718021 cagatacggc acgcgaaaag ggcgcgcatc ctgtgttcgt cacatcggtg cagcgccgcc 718081 gctttgatga aaacggacgg atcgagcata cgctcggtga gtatcccgat gcgatgaaag 718141 cactggcgaa ggagctcgat gtacctgtga ttgatctgct tgcgaaaaca aaggtgctgt 718201 atgaagcata cgggccggag gagtcgaagc gattgttcgt ttggtttcag ccgaatgaac 718261 atccgaatta cccggacggc attgaggaca atacgcattt ttcggaaaaa ggtgcaatgg 718321 aggttgcgaa gcttgtggca gaaggcattg aagagctcgg acttccgctt aaggaccacc 718381 ttgtgagccg ggagggaaaa gaacatgtat aaggaaggcg cttgcttgta ccgcaatccg 718441 ctccggtcta aaagcgatgt gaaggattgg cggatggagg gaggcggaca gatctcattt 718501 gacgatcaca gcttgcacct gtcacatgtc caggatgaag cgcactttgt cttttggtgt 718561 ccggaaacct ttccagacgg catcattgtg acatgggact tctctccgat cgagcagcct 718621 ggactgtgta tgctgttttt tgccgctgcg ggtattcgcg gcgaggattt gtttgaccca 718681 agtctcagga aaagaacagg aacataccct gagtatcatt caggagatat caatgccctc 718741 cacctgtcgt atttccgcag aaaatacgcg gaggaaagag cgttccgcac ctgcaattta 718801 agaaaaagcc gcggtttcca tctcgccgca atgggggccg atccgctgcc ttctccagac 718861 gacgctgatt ctccgtatcg tatgaagctg atcaaagaca aaggctatgt gcacttttca 718921 atcaatggtc tgcccattct tgagtggatg gacgacggca gcacatatgg gcctgtgtta 718981 acaaaaggaa aaatcgggtt ccggcagatg gcccccatga aagccgttta cagggatttt 719041 gccgtgcatc aagcggtgag aagatgaaga cgactgtaac ggatgcgctt tatgcaggct 719101 gcgaagcggt ggtgaaaata gcatggctca acgggctgtg gctgttgttt acacttttgg 719161 gcggcgttct tttcggatgg gcgccgagca cagctgcgat gtgtgccgtt ataaggaaat 719221 ggctgatggg gcaaaaggat gtcccgatat tttcgttatt tctcgatacc tataaaaaag 719281 agtttctcaa ggttaatgcg atcggattgg cgttttcggc tcttttgctc atattgtctg 719341 ccaactatca ttatttttct gccagtacga attggctgtc ctttgccgta acaagctgca 719401 cgctgcttgc agggcttttg tatatcatcg cgctgatgta tgtgtttccc ctttatgtgc 719461 attaccagct cccgcttcgc aaatatattc cgcaggcact gctgtttggc gccatgagac 719521 cgctgacaac tggctgtatg ctgatcgggt gcggatttgt cctttatttg ctgtatacgc 719581 ttcctggcct gatcccattt tacggcccgt gtttatttgg gcttgtgttg atgttttttg 719641 ctcttagggg atttcaaaag acggaggccc agcaccatca agccgggtaa caaaaaaatg 719701 acaaataagc aaaaaagtgc agtgtccgaa ataggcagat gcaaaaaagt gaaattgaag 719761 acagctcaca aagcgcataa aatccaattt aagtaagcgc ttacagataa atgagaagga 719821 gctgtctgat gattagacga aggaaacgca tgtttaccgc tgttacgttg ctggtcttgt 719881 tggtgatggg aacctctgta tgtcctgtga aagctgaagg ggcagcgcgg cagatggaag 719941 cgctgaaccg ggggcttgta gcggtcaaga cggacggggg catttttgtc agctggcggt 720001 ttcttggaac cgaaaacgca tctgttttgt tcaatgtgta cagagacggg caaaaactga 720061 atgctgcgcc tgtcaaaaca acgaactatg tggataaaaa cggttcggcg ggctcaacgt 720121 atacggttcg ggctgttgta aacggtaccg aacagccggc ttctgaaaaa gcctccgtat 720181 gggcgcagcc gtatcattcc gtcccgctgg ataaaccggc tggcggcacg acgccaaagg 720241 gtgaatctta cacgtacagc gctaatgacg caagtgttgg cgatgtggat ggtgacgggc 720301 aatacgagct gatcctgaaa tgggacccgt ccaactcaaa agacaattca caggatggct 720361 atacgggtga cgtgctgatt gacgcgtata aactggacgg cacaaagtta tggcggatca 720421 atctcggcaa aaacatcaga gcgggcgcgc actacaccca gtttatggtg tatgaccttg 720481 atggtgacgg aaaagcagaa gtggcaatga aaacggcaga cgggacaaaa gacggcacgg 720541 gcaaagtaat tggaaatgcc aatgcagatt acagaaatga acaggggcgt gtgctttcag 720601 gccctgaata tctcactgtg tttcaaggtt caaccgggaa agagcttgtc accgcaaatt 720661 ttgaaccggc gcgcggcaat gtgtcggatt ggggagacag ctacggcaac cgtgttgacc 720721 gttttctcgc cggcattgcc taccttgatg gacagcggcc gagcctgatc atgaccagag 720781 ggtattacgc taaaaccatg ctagttgcct ataacttcag ggacggaaag ctgtcaaagc 720841 tttggacgct ggactcctca aagtcaggaa atgaagcgtt tgccggacag gggaatcaca 720901 acctgagcat cgcggacgtt gacggggatg gaaaagatga gattattttc ggctcaatgg 720961 ctgttgatca tgacgggaaa ggcatgtact cgaccggctt aggccatggg gatgccctcc 721021 atacaggaga tcttgatccg ggccggccgg ggcttgaggt gtttcaagtt catgaggaca 721081 aaaatgcaaa atacggctta tctttccggg atgctgcaac tggaaaaatc ctttggggcg 721141 tttatgccgg caaggatgta ggccggggaa tggctgctga tattgacccg cgttatccgg 721201 gacaggaggt gtgggcaaac ggttctctct actcagcgaa aggggtcaaa atcggaagcg 721261 gggttccgtc ctcgaccaac ttcggcatct ggtgggacgg cgatctgctc cgggaacagc 721321 tggacagcaa ccgaattgat aagtgggatt atcaaaacgg cgtatcgaaa aatatgctga 721381 ctgcatcagg cgcagcggct aacaacggca caaaagcaac accaacgctt caggctgatc 721441 tgctcggtga ctggcgcgag gaagtggtgt ggagaacgga ggacagcagt gctctgcgca 721501 tttacacgac gaccattccg actgagcaca ggctgtatac gctgatgcac gatccggtgt 721561 accggcttgg catcgcctgg caaaatatcg cctataacca gccgccgcac acaagcttct 721621 ttttaggaga cggcatggcg gaacagccaa aaccaaatat gtatacgcct taactgaaag 721681 ggggaaggaa cgggctgcgc gcagcccgtt cccatcaaat gaaaccaaaa aagaggcaaa 721741 tggaatacct gaccagaggt ttgattgcgg tacagacaga acagggcgtg tttgtcagct 721801 ggcgttttct cggcacggat catgagacga cggcttttca cctttatcgg gatggaaagc 721861 ggatcacccg cgatccaatc gctgaaagca ctaattttct cgatcaaaac ggaacggctg 721921 actctgttta tcaagtggcg gctgtcaata aaggacggga agaaaagctt tccaagaaag 721981 ctcgtgtttg gcaggaaaat gtcctggagg ttcctcttgc caaaccggaa ggcggtgtga 722041 cgccggacgg aaagccgtac acttacagcg ccaatgatgc cagtgtcggg gatatagacg 722101 gggatggaga atatgaaatg atcctgaagt gggacccgtc caattcaaaa gacaacgctc 722161 atgacggtta taccggggag gtgctcatag atgcctataa actggacggc acctttttgt 722221 ggcgcatcaa cctcggcaga aacatcagag cgggtgctca ttacacgcaa tttatggtgt 722281 atgaccttga cggtgacgga aaagcagaaa tcgccatgaa aacagctgac ggcacaacag 722341 acgggaaagg acatatcatc ggtgatgagc aggccgattt tagaaacgaa cagggcagaa 722401 ttttgtccgg tccggaatat ttgaccgtgt ttaaaggaga aaccggtgag gcgctcacga 722461 ccgtggaata tgaaccgccc cgcggcaagc tggaggattg gggagacggc tatggaaacc 722521 ggatggaccg ttttctcgcc gggaccgctt atttggatgg ggagcggccg agccttgtta 722581 tggcgcgcgg ctactatacg agaaccgtgc tcgtggcata cgatttcaga aacggaaggc 722641 tcaaaaaacg atgggtattt gactccaacc agccgggaca tgaagcatac gcaggacagg 722701 ggaaccacag cttgagcgtg gcggacgtcg acggagacgg aaaggatgaa atcatatacg 722761 gcgcaatggc tgtcgatcat gacggaaccg gcctgtactc aacgggcctc gggcacggag 722821 acgcgatgca tgtaggggat ctggacccgt cacgaaaagg gcttgaagtg ttccaggtgc 722881 atgaggacgc cacgaagccg tacggactgt cgctgcgaga tgccggaacc ggtgagatat 722941 tatggggcgt ccatgctgga actgacgttg gccggggcat ggcggctcat attgatccaa 723001 gctacaaagg atcgctcgtc tggggaattg atccgccggg caatgatggc atgtcgtacg 723061 ggcttttcac gagcaaaggc gaaaaaatca gcgacaaagc gccctcttca gccaatttcg 723121 ccatctggtg ggacggtgat ttggtcagag aactgcttga tcatgactgg gacggaacga 723181 tcggcaggcc aaagattgaa aaatgggatg ctgaaaacgg ctgtctgaag acgatatttc 723241 agccggccgg cgtgttgtcc aacaacggca cgaaaggaaa cccggttctt caggccaacc 723301 tgttcggaga ctggcgggaa gaagtgatat ggagaacgga agacagcagc gcgctccgta 723361 tctatacaac aacacatctc acccgccact gcttttacac gctgatgcat gatccggttt 723421 acaggctcgg catcgcctgg cagaataccg cctacaacca gccgccgcac acgagctttt 723481 acctcggaac gggaatgaaa aaaccgccga agcccgccct gtacatagcg ggaagcaaag 723541 cggaggcgcc gctgtaggag gactaaggga taagacgcaa aggctgaacg ctacgccaag 723601 atgattagag aactggcagg acgaaccaat gctcaagcgc tgtacgcacc ggttttttca 723661 agggaagagc tatccgtgat ggaagctgta taaaaaacga ggaggaatga aaaaatggca 723721 aatcatattt atcttgccgg cgattcgact gttcaaacgt atggagacag cacaaatcaa 723781 gggggctggg ggcagtttct cggctcgcat ctgccggagc atattcaagt gatcaacaga 723841 gcgatcgggg gaagaagctc gaaaacattt gtggaagagg gcaggcttca ggcaatcctc 723901 gatgtgattg agccggatga ttggctgttc gtgcagatgg gccataatga cgcgtcaaaa 723961 aataagccgg agcgctacac cgagccctat actacttata aacaatattt aaagcagtat 724021 atcgcaggcg cgcgggaaaa aggcgcccat ccgcttctca ttacccccgt agcccgcttt 724081 cattacgaaa acggcgtgtt tttgaacgat tttcctgatt actgcattgc catgaagcag 724141 acggccgctg aggagaatgt ccagctcatt gatctgatgg agaaaagtct cgctttcttt 724201 actgagaagg gcgaggaaaa agtgtacacc tattttatga tttcagaagg gattaacgat 724261 tacacgcatt ttacaaaaaa aggcgcaaat gaaatggcga aacttgtggc aaaaggcata 724321 aaggagctcg gcctgccatt gacagaatcg atcatcaaag aaaggtgaaa atgtgatgag 724381 aaaactgtat catggcgctt gctattatcc ggaattatgg gatgaagaga cgattcagca 724441 ggacattgac atcatgcgtg aagttggcgt aaatgttgtg cggatcggcg aatttgcctg 724501 gtcagtcatg gaacctgaag aaggaaaaat tgacgtcggt tttttcaaag aaatcatcgc 724561 ccggctgtat gatagcggga tcgaaacgat tatgtgcacg ccgacgccta ccccgccgat 724621 ttggttctca catggccggc ccgaacgcat gcatgccaat gaaaaaagag agatcatggg 724681 gcatggctcc cgtcagcatg cctgtacgaa caacccgtat ttccgaaaaa aagccgccat 724741 catcaccaca gccatcgcca aggagcttgg ccggctcccg gggctgatcg gatggcagct 724801 agacaatgag tttaaatgcc atgttgcaga atgcatgtgt gagacatgct tgcgcctatg 724861 gcatgactgg ctcaaaaatc gctacggggt aattgagcgc ttgaatgaag cttggggaac 724921 cgatgtgtgg agcgagacct atcagacgtt tgagcaagtc ccgcagccgg gaccggcccc 724981 gtttctgcat catgcctctc tacgcactat gtatcagctg ttttcgatgg agatgatcgc 725041 ttcgtttgcg gatgaacagg ccaaaatcat ccgctgctat tcagatgcgc cgatcacgca 725101 taacggatca gtcatgttca gcgtggacaa tgagcgaatg tttcagaatc tcgattttgc 725161 ctcctatgac acgtacgctt cgcaggaaaa cgcctctgcc tttttattga actgtgattt 725221 atggagaaat ctgaaacaag ggcgcccgtt ttggattttg gaaacgagtc cgtcgtatgc 725281 cgcctcgctt gaaagctccg cttacccgca cgcagacggg tatttgcagg ccgaagccgt 725341 atcgtcctac gccttaggga gccaggggtt ttgctactgg ctatggcgac agcagcgttc 725401 aggcagcgag atttcccacg gttcggttct cagtgcctgg ggcgaaccca ccatcggcta 725461 tcaaaatgtg ctggcggttg agcgggcaag aaaggaaatc gagcctatta ttctatcgac 725521 tgaacccgtt caagccgagg cggcgatgac ttactctgac agagcaaaag catttattaa 725581 aactgagcct caccggggac tccggcatcg ttcgcttgtg acgcattttt atgaacgtat 725641 tctcaacacg gggattcacc gtgaccttat tccggaaggc gctccactgg acggctatcg 725701 cttgctgttt acgccatttg tgccgtattt gtcttctgaa tttatcaaaa aagcttcggc 725761 attcgctgaa gcgggcggca tctggatcac cgggccgctg acaggaggac gcacatgcga 725821 gcataccatt cataccgatt gcggacttgg cgaacttgag aaaacgtcag ggatcaaaac 725881 actttttacc tttccgatga atgagaacgt gaatacagga aaagcgtttg gcatcacggc 725941 gccgctcgga ctgtggagcg cggtgtttga cacagagagc ggaaacaccc ttggcacggt 726001 tgaagcagga ccgggggcgg gccatgcttt tctgacggaa cggaattacg gcgaggggaa 726061 aattgtcatg ctgggctcgc ttccatccgg gaaagaaggg gatgcgatgc tggaagcgct 726121 cgtcaggcat tatgcggagg aagctgttat ttccagccgg tcggatgtga cacccggcac 726181 gatcgttgcc ccgcgtatag gcgaaaacgg ccttgtgtgg atcgttgtga atatggatgg 726241 aaaaggcggg agcgtgacat tgccggaatc gggaacggat ttgttgacgc accgcttgga 726301 aaaggcgggg agactggcgg tcggaccgca tgaataccgt gtgattcaat ttgacaatca 726361 cagctgattc tttgtatcga atcagctttt ttctatggag ggagagacag atgaaaaaga 726421 tcaaatggtt atcaggacag ccaaaggtga caagcggcgt gacgtggggc atgccatgga 726481 aaaaaggaga attaaaaaaa ggagaccgtc tggcgcttat gaatgaaaac gcggaaacgc 726541 gatatgtgca aagcgaaccg tcggcctatt ggccggacgg gagcatcaag tggacgaagc 726601 acgcggcggt gtttggcggt caggaaaacc aaagctttac agtgcacaaa agagaagtgc 726661 cgcagccaac tgaatcgctc agcattcttg agacagagca tgatatccaa gtggatacag 726721 gagcactcgt ttgtaccatt cataaaacag gatctgattt cattcaatca ttgcagatca 726781 atggaaagcc gatcgccgca ggcgggaggc tcgttgcgat aagagaaacg agaaaagagt 726841 cagcggcgaa aatggttctt ttgcatgaaa ggtctgtcag ctttatcaaa cgggcggcga 726901 ttgagcagag tggtcctgtc aaagcagtag tcaaaatcga gggagtgcat gtgcttcata 726961 aaacgtatga ggaatggctg ccgtttgtca tccgattaac gttttatgcc gggctgtctg 727021 agatcggcct tgtgcacacg cagctgattg acaggagcgg taaactagaa ttcgttaagg 727081 ggctcggcat cgaattcgac ctttttttgg agggagagcc gtacaaccgc catttccgct 727141 ttgcgggaga gaaagggatg tataaagaac ccgcccagct gtttggcaca cgtaaattca 727201 atgaacgata tccgctttat gaaaaacaaa tcaatggcga aatgctgtct ccagatgaag 727261 agcataagga atggtttgca catggcacac agaatgcggt ttgggacgat gtcaagatcg 727321 tgcaagattc cagcgatcat tacagcctgt caaaacggac cggaaaagat tatgcgtggg 727381 ttggaatgct gcatggcagc cgggcgaagg ggctctgcta tgcgggcgga aaaaatggcg 727441 gtgtggctct cggcctgcgg tatttctttg agaaatatcc ttcagcactg gaaatcacag 727501 gtcttgccgg cagccgcccc aaaatgacta tctggctttg gcctccggac ggcgaagcga 727561 tggatttgcg gcattataca ggaaacactc acgtggccag cgcgtatgaa ggctttgatg 727621 aaatgcgctc tgatccgaca ggcattgcga acacaaatga aataagcctg gcgtgctttt 727681 cgcacatgcc gtctgacgaa gtcctcaatg cgctggctga caaatggcag gcgcccccgc 727741 tcattgtatg cgagccggac gtctattacg aatcaaaagc actcggggta tggagcatca 727801 ttgacacatc ccatccgctc aaaaaagagc tggaagaaca gcttgatgcg gcctttctgt 727861 tttataaaaa ggaagtagag caacgcagat ggtacggttt ttggcattat ggcgatgtca 727921 tgcatacgta tgacccgatc cggcatatgt ggcggtacga tctcggcgga tacgcatggc 727981 aaaacaatga gctcgttccg accctatggc tgtggcaggc gtttttccgc tcaggcagag 728041 aggatatctt ccgaatggca gaagccatga cccgccatac gagtgaaacg gacagctttc 728101 acctcggtga atatgccggg cttggctcac ggcataatgt tgtgcactgg ggatgcggct 728161 gcaaggaagc gagaatcagc atggccgggc ttcataaatt ctattattat ctgacgggtg 728221 atgaccggac gggagatctt ttgacagaag tgaaggatgc cgattatgcc cttgtcaaaa 728281 ccgatccgat gcgcgctttt tacgagaaag gcaagcaccc gactcacgcc agaacgggac 728341 cggactgggc ggcgttttgc tcgaactggc tggcggaatg ggagcggacc gaaaattcgg 728401 aatatctcaa aaaaatcgaa acgggaatca actgtctgaa gcggctgccg ctccgcttat 728461 tatctggccc gacatttgaa tatgatccgg cgacctcgat gcttcatcat atgggagacg 728521 gcattgcggg cggatatcat atgatcattg ccttcggcgc gccgcaagtg tggatggagc 728581 tggctgagct tcttgatgac tgggaatggg aggatatgct gagtgaattc ggcgaatttt 728641 acacactcag tgatgaggaa aaacgaaaaa aaagcggagg cgctcttcat gacgggcatt 728701 ttcactggcc gatgttcgcc gccggtatga cagcctacgc cgcaagaaaa aagcaagatc 728761 ctcatctcgc cgccaaagcg tggaatcttt tgctagaaga taagctcagc catacgccgc 728821 ttccgatcaa accggagcgc atcgagacat ggacgcagct agaggagctt ccatgggtga 728881 caacgaacac tgtctctcaa tggtgtttaa atgtcatagc ggcgctggaa ctgatcggag 728941 attcccttcc ggcaaaaaaa gaaacatcgg gcaaaaaagg ataacagccg gaatttcata 729001 ggagaaatgg tgcaaaaaat gaagattgca agaatttatg taagcgcttt atattgagag 729061 gggcaaaggg gaaatgcaaa ttgaaaaaag ggggacttac gcaacatgaa aataagaatg 729121 cgaaaaaaat ggatggcctt gccgcttgct gccatgatga tcgccggatg cagccattcg 729181 gaaacatcca attcagcaag cggttcgaaa gatacgatca aaattatggc gccgctctta 729241 tcgccggaaa gcccaagtga taagagccct tcattaaaag cgctcgaaaa atacacaggc 729301 aaagagatta aggtcacatg ggtgcctgat tcatcctaca acgacaaatt caacatcgtc 729361 atggcttcag gagagatgcc tcacgcgatt gtcattaaag ataagtcagc cggctttatc 729421 aaatctgtca aagcaggggc gttttgggag ctgtctcctt atttaaaaga ctacaagaat 729481 ttaagccagg cagatgaaaa gattttgaag aacagctcgg tgaacggcga ggtgtacgga 729541 atctacagaa cgagggatct gatcagggcg tgtatgatca tcagaaccga ctggctgaaa 729601 aatgtcggtc tggatatgcc ggaaacgctt gatgatttct atgaagtgct gaaagccttt 729661 aaggaaaaag atcctgacgg aaacggcaag gatgatacgt acggcatggt cgtgccgaaa 729721 tggatgggac tcggcaacgg aagcccatgg gatgttctgc aaatctggtt cggcgctccg 729781 aaccgctacg gtgttgaaaa cggaaagctg attccagatt ttacaacgaa ggaatacatg 729841 gatgcgctca cgttttttaa aaagctctat gatgagggct tgatcaataa ggactttgct 729901 gtcatggatt ctgcgaagtg gaatgatccg gttgtaaaag gaaaagcggg tgtcatcgtt 729961 gatacaggct caagagcgtc tcaaatccaa agcgcgatgg aggaggcgga tgagtcgaac 730021 aaggatatca ttgatatcgt cggctcgctt gagggaccga atggcaagcg caccttcccg 730081 acatctggtt attcaggcat gatcacgata ccaaaatcaa gcgtcaaaac cgaaaaagag 730141 ctgaaagagg tgctgtcctt cctcgataag atgaatgata aggaagcgca gattctcacg 730201 aacaacggag tgaagggccg caattacgag ctcaaggacg gcgtattcac ctcacttgaa 730261 aaaaacaata aatctctcct gtatgagcat gaaggcttgg cacagttcag catgtcgatt 730321 ccgaaaagcg agtattacat cgaagaccag aaaaccaagc tcttccagca tcgcaaggac 730381 atcataaccg aaggagaaaa aatagccgtc tttaaccctg ctgagtcgct tgtatctgat 730441 gtctataccc aaaaaggagc ccagcttgac aacatcatcc tcgacgcgag aacacaattt 730501 atcattggag aaattgatga aaaagggttc gatgatgcgg tggagctttg gaaaaaaagc 730561 ggcggcaatg aactgatgaa ggacttgaac aaattgtacc aatcgtcaaa ataaaccgat 730621 gcgcctgcct ttcggcgggc gccccggtat cacgaaagga gaacagatat ggaaacagtg 730681 ccgaagaaga gagatgcacc tgttctcacc gctggaaaag gcatcagctg gatggctgcg 730741 ctcaaacggg acaaatggct ttatcttctt cttattcccg gtctgcttta tttcttgatt 730801 ttcaaatact tgccgatgtg gggtgtgctg atcgctttta aagactattc gccatatctc 730861 ggcttctgga aaagcgaatg ggtcggcttt gattatttca aagacttttt tatgaatccg 730921 gattttttcc ggctgctgcg caacaccctc atgctggcga gtctggatct tttgtttgcc 730981 tttcccgcgc ctctcatttt ggctctgctt ttgaatgagg taagaaaggc cgtgtataaa 731041 agatgtatcc aaacctttat ttacgtaccc cattttgtat catggacaat tgtggtcagc 731101 atcaccttcg ttttctttac tgtcgataca ggtgtgatca acaaattgat tatgagcctg 731161 acaggtgagc agatttcttt cttgtcggat gcagactggt tccggccaat gattgtgatg 731221 caaagcattt ggaaggagac aggctgggga acgattctat ttttggcagc gcttgctacg 731281 gttgatcaag agcagtatga agcggccatc atggacggag cggggcggtt caggagaatg 731341 tggcatatta cgctgccggc gattagaagc accattatcg ttttgttgat tttaagaatc 731401 ggcagctttt tgaatcttgg ctttgaacag gtgtatttga tgacgaactc actcaaccgc 731461 agtgtggctg acatcttcga cacgtatgtg tacatgatgg ggattaccca aggggcgtat 731521 agctacagca cggcggtcgg tttgtttaaa tcagttgtcg ggattatctt gatttttggc 731581 gccaattaca ttgcgaaaaa gtttgatcag gaaggattgt tttagaggag ggagaggtat 731641 ggctgaaatt cacacgatgc acaacaccaa agccggacgg gtgtttgacg tctgcaacat 731701 tctgtttctc ggcggtgtcg gcgcgattac cattttgccg tttttatata ttatcgccgg 731761 ttcctttgcg acagaagcgg aactcgccca gcggagcttc tttattttcc cgaaaacctt 731821 tacacttgat gcttacaagt atgtgttttc gacaccgacg ttccttcgaa gcatgggcgt 731881 gtccatcttc atcacggtgg ttgggacggc tgtacagctg ttttttacct tcacgatggc 731941 gtatccgctg gcgaaacggc atgtgaaggg acggaatctg ctgttgaatc tggtgatttt 732001 ctccatgctg ttttcaggcg gcatgattcc gacgtacctt gtcgtaaaat cacttggcct 732061 tttggatacg tattgggcat tgattctgcc gatggcgatt aatccgttca accttattat 732121 tatcaaaaac ttctttcagc agctgccgcg cgagctggag gaatcagcaa aaattgacgg 732181 ctgttccgaa atcggcgtct tctggcggat cgccctgcct ctgtcaaagc cagttattgc 732241 gacctttgcg ctgttttatg cggtcgggat ttggaatgat ttcttccacg ctctcttata 732301 tatcaatgac agtgcaaaat ggccgctgca aatggtgctt cgccaagtca caattttatc 732361 ggatttaacg gcgaccaatg gtgatacgat gcaaaatgca gttccgccgg agcagggaat 732421 taaactcgct gtcattgtca ttgcgacgct gccgattttg gcggtctatc catttttaca 732481 aaaacacttt gcaaaaggaa tgctgatcgg ttcggtgaaa ggctgagaaa gggagtgttt 732541 catatcagta cattagatca gattaagatt gcctatatcg gcggggggtc ccaaggctgg 732601 gccagaagcc tgatgagtga tttgtcgatt gatgaacgga tgtcaggcac ggtggcgctc 732661 tatgatcttg attttgaagc cgctcagaaa aatgaagtga tcggcaatca cagcgggaac 732721 ggcagatgga gatatgaggc tgtttctact ttgaaaaagg cgttatcagc cgcggatatc 732781 gtcattattt ccattttgcc gggatcactg gatgatatgg aagtcgatgt gcacttgcct 732841 gagcgctgcg gtatttatca gtctgtaggt gatactgtcg ggcctggagg gatcatcagg 732901 ggcttgcgtg ctgtgccgat atttgcggaa attgcccggg caataagaga ctacgcacct 732961 gaatcatggg tcattaatta tacaaacccg atgtctgtct gtacaagagt gctgtataaa 733021 gtgtttcccg gcatcaaagc gattggctgc tgccacgagg tattcgggac gcaaaagcta 733081 ttggcggaaa tggtcacgga aaggctgggg attgaggtgc cgcggcgtga ggatatccgc 733141 gttaatgtgc tcggcattaa ccattttaca tggatcacaa aagcctctta ccgccatatt 733201 gacctgttgc ctatattccg tgaattcagc gcgcactatg gggaatcagg atatgagctg 733261 gagggggaat gctggaggga cagcgtcttt tgttcggcac accgtgttgc gtttgattta 733321 tttgaaacgt atggcgccat ccctgctgcg ggtgacaggc atctggcaga gtttcttccc 733381 ggcccatacc tcaaacagcc tgaagtatgg aaatttcatc tcacacctat atcattcaga 733441 aaacaagaca gagctgagaa acgacaagaa acagaacggt tgatcgtgca acaacggggc 733501 gttgctgaga aagcttcggg agaagaaggc gtgaacatca tagcggctct tctcggattg 733561 ggtgaactcg tcacaaatgt aaatatgccg aatcaaggcc aggtcttaaa ccttcctata 733621 caagccattg tcgaaacaaa cgcattcatc acaaggaacc gtgtccagcc gattttgtcc 733681 ggagcgcttc cgaaaggtgt ggaaatgctg gcggctaggc atatatccaa tcaggaggca 733741 gtggcggacg caggtttaac aaaggatact ggcctcgcgt ttcaagcctt cctcaatgac 733801 ccgcttgtcc agattgaccg cagtgatgca gagcagcttt tcaatgacat gctccaatgc 733861 atcatgcaaa gctgagcttg ccgattagct ctttccggtt tagaaaggaa agcattgacc 733921 atactgatag tataatcaag aagtaggtgc tatcaatatg ggaaattatt taagtgttgc 733981 ggtagaactg gtctgcggtt taggcatttt atttatcatc ttaaagcttc tcgggaaaac 734041 ccaattttct caaattacgc cgtttgactt tatttctgct ttaattttag gtgaattggt 734101 cggaaatgcc gtctacgatc atgaaatcaa aatcaaagaa attatttttg cttcgctatt 734161 gtggggcgtg ctgatttata ttattgaatt tatcacgcaa aaaatgaaat catcgcgaaa 734221 gttcttggag ggcgagccga atatcgtcat ccgcaaaggg gagcttcaat ataaagtaat 734281 gaagaaaaat aagatagaca ttaaccagct gcaaagccta ttgaggcaag ctgggagctt 734341 ttcgatccaa gaagtagaat atgcgattct tgaaacaaac gggatggtca gcgtgcttcc 734401 aaaatcagac tttgacaaac cgacaaataa ggatttgcag attccttcga agtccgtttc 734461 tctgccgatc acgttaatca tagatggaga gattgtgcgg gataatttga aggaagcagg 734521 tgtggatgaa cagtggctga aacaagaatt gaaaaagaag aacattgata agacagagga 734581 cgtgttattt gcagaatggc ataaaaataa gccgctgtat actgtaacgt acgaacaaag 734641 cagatcaaca tgactcttag aaaaaagctt gcagcaaggc gcaagctttt tattgattgt 734701 atgtcccttg tttgacagca cgtacatggt acatgctcac ttcagtgctg atcagatagt 734761 caggctttgg tttgcctttg tttgctttat ggccggcgat atgcgcatcg cttttttccc 734821 attgcttcca gtgatcctct gattcccagc gaatcatgac aacaacttct tcatcaccgc 734881 ggcgcacatt tttctcaagc actgtcacat caattaaacc ttcttgtttt tcaatgattc 734941 cttcagcgct gaaacgttct atgactttat ctgcaaagcc ttctttaacc gtcatttttc 735001 tcaactgtac aaacatttgt ctcactccaa tcattctcac atatgaataa ttgtaaatga 735061 aattcattct caatgtcaaa gaaagcgcag ggcggaatcg aaccgccgtg cgcaacagtt 735121 tattctttta ataaaaacac atttccgtct tcgtccttaa attgaacgaa ggtgccccac 735181 tccatttgat tgggctcacc gagaaattct acaccgtttg tcttcatttt ctcgtatgta 735241 ccaaagatgt cttcgcattc aaacacaata gaagccttca tttgctctga gcctttcatc 735301 atggctttcg ggtaaatgac taaacgagtc tcggctcctt ttggcgcaac ctccagccag 735361 cttgcttcag gtcccattgg gtgatccgct gcaatatcaa agcctacctt ctctgtccaa 735421 aattgcttcg ctttctgctg gtcctcgaca tatacagcaa cagtgccaat ttgtttgatc 735481 atagggaaac ctccaagttg aaaagataat aatactataa cctgtttacg gccgaagtaa 735541 cataaaaaaa tcagccggga aaccggctga ttattaaaat gagcagctta caacatcgat 735601 gtgatttgtg tctaaggcga aataaaccca gcggcgccgt gaggaatccc aataaaagcc 735661 gccgacggat cttctgccaa ggatgatcgg gtaaaaccaa aatgagcggc cattggttaa 735721 ccagacatag gtaaatcgga aaaggcaagg acgaatggtg attggttcaa ctaacaaaac 735781 ggctccttga gaaccctgcg gttttggggg tttcgctggt atttgggaag gaggaggtcc 735841 ctgcggcgca ccgccgaagc ctgggctggc accgctgcca ataccagggc cggagccgcc 735901 gccaaagcct ggaacagcac caccgccaat gccaggaccg gagccgccgc cagagcccgg 735961 aacagcgccg ctgccaatgc caggccatgg atatcggtat tcatattcaa aagcaggcca 736021 aggctcataa aaatgccccg caaacatata aggatcaaca taatacatgt gataacgtcc 736081 tttctcattg taaactgtac attgcagttt atgcgggcgg actcttattg gtgcattcgc 736141 ctaaggatat gaagctggaa tgctctcaga gagcagaatc atttgatttt tctctagtct 736201 tattcacaat tccgatttat cattttataa tgaaagtgct tctattacga aaaaggagac 736261 agaccgtgaa tatcgatcaa ttattatatc aatatatcat agacaacact gcggatatta 736321 ctgagaaatg gttcagtttg cgttgccagc taaaaggcga gctatattcc gccagccatt 736381 taagtgaaga aacgaaaaca cttttaaccg agcagcatac atttaccaat ataacaatcg 736441 caagcgcatt tctggaggat caaaccgatt ttcaagaaaa catgacaaaa tgggcgcaaa 736501 acgttgcgaa aaacagggta gagcaggatg ttcaagtgca tgaggtcgta gaagccatat 736561 ccaattcaag aatctcattc tgggacgcag tcgccacatt tataaaagag aatcaggaga 736621 ttgtgacaaa tgaggatgca gaccgatgga accgcattgt gaatcagtcg ttcgataagc 736681 tgattattga attctccgag cagtaccaaa aattcatgct gatgaggctt acatctcagc 736741 aggaactgat ctcagagctt ggctgcccgg tcatttccat tgccgatgga atcgggatat 736801 tgccgcttat cggctccatt gatacaaaac ggcacaggtc attttagaaa cagtgccggt 736861 ccgctgtgtc gagagaaaaa tcacaagcct cgtcgttgat ctttcgggtg ttccgattgt 736921 ggataccatg gtggctcagc aattgtacaa cctgtctaaa acacttttct tattaggcgt 736981 caaagccgta ttttcaggaa ttcgcccgga tgtggcccaa acatcgattc aattggggct 737041 tgattttagt gaatatgaaa cgtacggcac gctgaagcag gcattagaaa acatgggtgt 737101 ccgctgtatt gttgaggaat tggaagaaaa caaataggaa gtttccaggc atatgattgt 737161 ccgtcaccgg gtgatcatat gcctttttga tttgaacaga aatcaccatt gatttatcga 737221 aaaaaacata atattataat tcttataaga atactgtgaa ttaaaaccta ttcaacaggg 737281 gggaaggtct tttggtttct aaatcaacga ttgatccgga agtgattgaa aaaatcatca 737341 gctcgctgga aacactcgat ttcggcacgg ttcagattac ggttcatgat tctcagatta 737401 cccaaattga gaaaatagaa aagcaccgtt tttcgctgaa aaggaaagaa tcaaaatgat 737461 aatgtaaagg gcgtttgttt tcattaaatt ctccttaaaa catatacata tttcatccaa 737521 tttttatata atagaccttt aagatcattt tttaggagga tttttgacat gcaagctacg 737581 gttcacgaga gtaagcaatc gatcatgcaa cgcattttga cagtctttgt cttcacattg 737641 ctgatcgcga ctgtcggcct ttttatcggc caatttgttc ctgtcgcttt gatgctgccg 737701 ctttctattc ttgaagtggc gatgattatt ctggccttct ggatgcgcag aagaaaagcg 737761 gtcgggtatg cgtttgtata tacattcgcg ttcgtttccg gcattacctt atttccgatc 737821 gtcagccatt acgcttccat cgccggcgcc tatgtcgtgc tcgaagcctt tggctctaca 737881 tttgtcattt ttgccgtctt gggcacaatc ggcgcaaaaa tgaagaagga tttatccttc 737941 ctgtggtcgt ttctgctggt tgcggtgctc gcactcgcag tggtagggat tttcaacatt 738001 ttcagcccgt taaactcagc ggcgatgatg gcgtattccg tgatcggaac catcgtcttt 738061 tccctttaca ttttgtatga tttgaaccaa atcaagcacc gccacattac ggaagacttg 738121 attccggtta tggcgttatc gctgtaccta gactttatca acttgttcat caacctgctc 738181 cgcttcttcg gcattttgag cagtgatgat taatgaaaaa gcgtctgtca ttggataggc 738241 gctttttgcc atacatcaaa aaggcaggtg gagtattggt gaaaaaacaa atgggcgcat 738301 atgtatctct ggcagcagct atggcgatcg tcggcagttc tgtcgttgtc ggcaagctga 738361 tggtcgaacg gattccggtc tttctttcct caggattgcg ttttttgatc gcttctgtcg 738421 tattgctcat gctgctgttt tgcattgaaa aagggtttcc ggctttgacg aaaaaagatg 738481 tgttcgtatt actggtgcaa tcattcacag gcgtgttttt gttcagtatt tgcctgctgt 738541 atggggttca atatacgacg ggaacggaaa gcggcatttt gacaagcaca acccccatgt 738601 tgatcggtat tttatccttt ttcctgctga gagaaaaaat tgagaaaaag acgctgatcg 738661 gcattttgct ggcggtttgc ggcgtaatgg cgattaattt gtttggagcc gggagccaag 738721 acgggacgcc gcacgcctta ttcgggaaca tgctgatcat tgctgcagtc attggcgaag 738781 cgttgtttac attgatggcc aagctgctat ccccgcatat ttcggcactg gcgatttcga 738841 ccttcgtatc gctcttcggc ttcctgtttt ttctcccgtt tgctttgttt gaggcctctt 738901 catttgatta cagcgtgccg actgttttgg attggtcgta tgtgctgtat tacgcgcttt 738961 ttgtcactgt tttggcgttt tacttatggt atagcggggt gacgaaggtg ccggcgggtg 739021 tatcgggcat tttcacatcc gttcttccgg tctcagctgt cattttgtca ggcgtgatat 739081 tgaaggagcc atttgagttt gtgcatttca tcggcattgc atgtgtcatc ggcggcatat 739141 ttgttacggt cataaagaaa aaacagccgg atgcgtatcc ggctgcagaa gaaaagacgc 739201 tatagcctgt ccggatcgga cgggtttttt agtctttaaa cacgctcagc ctttcaaaaa 739261 gatcaccaag catcttcacg aacatgtctt tttcctcgtc gctgtagttt tccatgacag 739321 cggatatttt gctgaaatgg ccgggcagaa attgctccag gcgtgctttg ccttctgttg 739381 tcagttcaat gctgattttt cgtttatcct ctgtgtgatg cctgcggctg acaaaaccgt 739441 ctctcgccag cccgtctagc aggcctgtaa ttgttgcttt cgtgacattt gaccgcttgg 739501 caagctctgt cggacttaac ctatgatcct tggcatcaaa gagcagcatc aggattttga 739561 attttccttc tgaaagccct cggccagcaa agtaatgctc catcacatga ttcatttttt 739621 ttgaaatatc aaaaagagat aaaaacaatt caagagagcc ggcgtcaata ttggcatacg 739681 tttcggcgtg ctctgttata tgcttatatt tcggtaaatg ttttaattcc atcgcaatta 739741 gctcccgtac attcgttgtg acacgattat aaaggaggga aaaccataac gcaacttggc 739801 ttggagatga ttgacagctt ttcttgggac atagtaaggt aatatagtta ggcgcctaac 739861 taatacatat agagctgaaa aggtggttat tgatatgaaa catatgttaa tagcaggagg 739921 cggaatcggc ggcttgtcag cggccatttc tctccgtaag gcagggtttt ccgtcacctt 739981 atgtgaagcg gcttcagaaa atcgaaaaac aggtgcgggg attcttcagc cgcaaaacgc 740041 actggcggtg ttgaaagaac tgggcgtatt cgaagattgc tgtaagcacg gctttcaaac 740101 agaatggttt aaaacgtttg atgaacaggg gaatttgctg tttcaagtca gtgaatcctt 740161 tttagacgat tcacttccgg gacgcaataa tatcctgcgc aaaacgttaa atgacattct 740221 catgaagcat gccgaggcag tgggtgtaga catcaagtgg gggaaaaagg ttgtcgccta 740281 tgaagaaact gctgaatcgg tcactgcctt atgtgaagat ggagaaaaga tgcaggctga 740341 cattctggcg ggctttgacg gcattcactc cgttgttcgt gataagatgc tgcaaaagga 740401 aacggaaaaa gagcatctcg gcatgggagc gtggcgcttt tatatcgaac ttcctgatta 740461 cacattcgag gacgcaacat tcatgtatag aagcggagac acacaaatcg gggtggtgcc 740521 attggcacaa cacgctggct atgtcttcgt cctccagcct tgcacgagcg attactggga 740581 tgaggaagat acccggtttg atagagtaaa agagattctt tctggttttc gggggctgga 740641 ttttgtcaca aagcacatgt caaaacagca tcctgtcatc tttaacaaac tggagcaggt 740701 cgccgtgcag gagccatggc ataaaggccg cgtcatcatc ggaggagacg ccgcccacgc 740761 cggtgcgcca accctggcac aaggagcggc aatggcgatc gaggatgcca tcgtcctcgc 740821 cgaagaactc caaaaccacg ccgaccacga aacagcatta caggcgtact ataaaagaag 740881 agccccacga gcgctcaaag tccagaacct atcatctgaa atcgtccgcc gcaggctgaa 740941 aggagagccg ggagcggaag aactgattgg ggagtgctat gcggtgttga gggaagggta 741001 ttaaatagga aaagtccaga aagtgatttc tggacttttt agtcttgctc tgttttattc 741061 cttatccgct caatcacctc atgcagcccc tcaggcttat aaaactccac cggtgaactg 741121 cctttctcaa acgaaatcgt ctcggcttca atcagcgcga catagcgccc gtttactttt 741181 gcgagatgaa tagaatcgcc aaaatccgct agcaatccct taatctctgt ttctccgact 741241 ttcattttca gctgggcctc tggcgtgtgc tcgatgattt gggcggaggc ttcgatgact 741301 tgatgggtgt cgaggcgctc ttggatttcc cgtttttcgc ttgcttccca aatctcaatg 741361 tcgtgctcga actgcttgag ttcttcgctg ttgtcttcaa atgtctcgta gacgtgctct 741421 tgtaccatgt tcatgacctg atttttcatg atttctggca tcgattctcc gtactcgacg 741481 aatttcagaa agtcctcaaa atagcgggcg tgcgaggcct ggtggatttt cagttcacct 741541 tcctcgacca ttccttcctc tggcatgtac gggtattgga tgcttttcat gttttttgtc 741601 gtgatcgcca tttcgacttt tttaatgaga gaagacgcgt cagagatgcg ggcgaccttc 741661 ggctcaaaat cacatttcat aatgaagaca aatgactcat caaagtattt tctcggcacg 741721 gccgaagcga cgagaaacac gccgccgcga accgcgcttg tgtcaaggta cgtgcggacg 741781 aactgctcgc tcagctcatt gaagtcttct tttgtttccg ccagacgcgc gcggttgaac 741841 atgttgtagt ttgggttgga atcgagctcg tggccgggct cgacgataaa atggccgatt 741901 ttcgtcggca cctgctcgga ctgcggatgg cggtcggctt tccgtttaac gatttttttc 741961 agttccccgt cgagaaagtc cttcagctcg ctttcttcaa attctcccgt atcaagggtc 742021 tggaagtgct tgaactgctt gttcgcctgc tcatctttgc cttccacctg tatgacataa 742081 aaggataaaa accgaatttc aaaatccata tataaactca ccttattcgc gtattgtaca 742141 gcttctcaag tatagaaaaa acagcgatca tgcgtcaatt gggagaacgg aataatcatg 742201 accatgaaag ggaaatgtag tcaaatagaa ggcatttcat acggaaagga atggttcgat 742261 gaaggaaaca agcccgattc ctcagccgaa gacgtttggg ccgctcggca atttgccttt 742321 aattgataaa gacaaaccga cgctttcgct gatcaaactg gcggaagaac agggcccgat 742381 ttttcaaatc catacacccg cgggcacgac cattgtagtg tccggccatg aattggtgaa 742441 agaggtttgt gatgaagaac ggtttgataa aagcattgaa ggcgccttgg aaaaggttcg 742501 cgcattttcc ggtgacggat tgtttacgag ctggacgcat gagcctaact ggagaaaagc 742561 gcacaacatt ctgatgccga cgttcagcca gcgggccatg aaggactatc atgagaaaat 742621 ggtcgatatc gctgttcagc tcattcaaaa atgggcaagg ctcaacccga atgaagcagt 742681 cgatgtcccg ggagatatga cccggctgac gctcgacacc attgggctat gcgggtttaa 742741 ctaccgcttt aacagttact acagagaaac gccccacccg tttatcaaca gcatggtgcg 742801 ggcgcttgat gaagcgatgc atcaaatgca gcggcttgat gttcaagata agcttatggt 742861 cagaacaaag cggcaattcc gctatgatat tcaaacgatg ttttcgttag tcgacagcat 742921 tattgcagag cgcagggcga atggagacca ggatgaaaaa gatttgctcg cccgcatgct 742981 gaatgtggaa gatccggaaa ctggtgaaaa gctcgacgac gaaaatatcc gctttcagat 743041 catcacgttt ttgattgccg gccatgaaac aacgagcggc ctgctttcct ttgcgactta 743101 ctttttattg aagcatcctg acaaactgaa aaaggcgtat gaagaggtcg atcgggtgct 743161 gacggatgca gcgccgacct ataaacaagt gctggagctt acatacatac ggatgatttt 743221 aaatgaatca ctgcgcttat ggccgacagc tccggctttc agcctttatc caaaagaaga 743281 cacagtcatt ggcggaaaat ttccgatcac gacgaatgac agaatttctg tgctgattcc 743341 gcagcttcat cgtgatcgag acgcttgggg aaaggacgca gaagaattcc ggccggaacg 743401 gtttgagcat caggaccaag tgcctcatca tgcgtacaaa ccattcggaa atggacaacg 743461 ggcctgtatc ggcatgcagt ttgcccttca tgaagccaca cttgtgttag gcatgattct 743521 aaaatatttc acattgattg atcatgagaa ttatgagctt gatatcaaac aaaccttaac 743581 acttaagccg ggcgattttc acatcagtgt tcaaagccgt catcaggaag ccattcatgc 743641 agacgtccag gcagctgaaa aagccgcgcc tgatgagcaa aaggagaaaa cggaagcaaa 743701 gggtgcatcg gtcatcggtc ttaacaaccg cccgcttctc gtgctgtacg gctcagatac 743761 cggcaccgca gaaggcgtcg cccgggagct tgctgatact gccagtcttc acggcgtaag 743821 gacaaagaca gcacctctga acgaccggat tggaaagctg ccgaaagagg gagcggttgt 743881 cattgtgacc tcgtcttata atggaaagcc gccaagcaat gccggacaat tcgtgcagtg 743941 gcttcaagaa atcaaaccgg gtgagcttga gggcgtccat tacgcggtat ttggctgcgg 744001 cgaccacaac tgggcgagca cgtatcaata cgtgccgaga ttcattgatg agcagcttgc 744061 ggagaaaggc gcgactcggt tttctgcgcg cggggaaggg gatgtgagcg gtgattttga 744121 agggcagctt gacgagtgga aaaaaagcat gtgggcggat gccatcaaag cattcggact 744181 tgagcttaat gaaaacgctg ataaggaacg aagcacgctg agccttcagt ttgtcagagg 744241 gctgggcgag tctccgctcg ctagatcgta cgaagcctct cacgcatcca ttgccgaaaa 744301 tcgtgaactc cagtccgcag acagcgatcg aagcactcgc catatcgaaa ttgcattgcc 744361 gccggatgtt gaatatcaag agggcgacca tcttggcgta ttgccaaaaa acagccaaac 744421 caatgtcagc cggattcttc acagattcgg tctgaaggga accgaccaag tgacattgtc 744481 ggcaagcggc cgcagtgcgg ggcatctgcc attgggccgt cctgtcagcc tgcatgatct 744541 tctcagctac agcgtcgagg tgcaggaagc agccacaaga gcgcaaatac gtgaactggc 744601 gtcatttaca gtgtgtccgc cgcataggcg cgaattagaa gaactgtcag cagagggtgt 744661 ttatcaggag caaatattga aaaaacgaat ttccatgctg gatctgcttg aaaagtatga 744721 agcgtgtgac atgccgtttg aacgattttt agagctttta cggccgttaa aaccgagata 744781 ctattcgatt tcaagctctc caagagtgaa tccgcggcaa gcatcgatca cagtcggtgt 744841 cgtgcgcggc ccggcgtgga gcggccgtgg cgaatacagg ggtgtggcat caaatgattt 744901 agctgagcgt caagccggtg atgatgtcgt gatgtttatc cgcacaccgg aatcccggtt 744961 tcagcttccg aaagaccctg aaacgccaat tattatggtc gggccaggca cgggagtcgc 745021 gccatttcgc ggtttccttc aagcccgcga tgttttaaag cgggagggca aaacgctcgg 745081 tgaggctcat ctctattttg gatgcaggaa cgatcgggat tttatttacc gagatgagct 745141 tgagcggttt gaaaaagacg gaatcgtcac tgtccacaca gccttttccc gaaaagaggg 745201 catgccgaaa acatatgtcc agcatctcat ggctgaccaa gcagatacat taatatcaat 745261 ccttgaccgc ggtggcaggc tttatgtatg cggtgatggc agcaaaatgg ccccggatgt 745321 ggaggcggca cttcaaaaag cgtatcaggc tgtccatgga accggggaac aagaagcgca 745381 aaactggctg agacatctgc aggataccgg tatgtacgct aaggatgtct gggcagggat 745441 atagataaag aagactggag acatccagtc tttttagtcc tttcgaaaaa atggtgatcg 745501 cgctaaacat tgatgcatac aataacttca gtccgccgga agggcgggct gtctgcaaaa 745561 cctatttttc gtttttgcta gtttatgtta ttcttatact cggtatctat ttcttttttc 745621 aaaggcacac atgacaaaag aaatcctttt tttatttccg agaaaaaaat gtgaaacgaa 745681 atgaaggttt ctttcgtcca gtgattggtt tccaaatggt tgtaataaaa atgatatggt 745741 gcgaaacata aatattccgg cttgccgcgg tgtatttatt gttgtgtgat gccttgattt 745801 tgtttggaaa gaaggaattg gaaggcagga tataaagagc aggtaaatat gaatgaagaa 745861 cttaaagtgt ttaagaaagt agaggttgcc atgaagaaac ttttttctta caaacttagc 745921 ttttttgtgc tggctgttat actgttttgg gcaaaaacgt atttatccta caagactgag 745981 tttaatcttg gggtaaaagg cacaactcag gagatcctcc tgatatttaa cccattctca 746041 agcgccgtct tctttttagg actggctttg ctggcgaaag ggcgtaaatc agccattatt 746101 atgctgatta tcgatttctt gatgacattt gtgttatatg caaatatttt attctatcgt 746161 ttctttgacg atttcttgac gttcccgaac attaaacagt ccggaaacgt tggaaacatg 746221 ggagacggga ttttcagtat catggccggt catgatattt tctatttctt agatattatc 746281 attttgattg cggtattgat ctggagacct gaattaaaag aatacaaaat gaaaaaacgc 746341 tttgcatctt tagtgatcct ttctgggatc gcactgtttt tcatcaacct gcactatgcg 746401 gaaaaagacc gtccgcaact gctgacaaga acgtttgacc gcaattatat tgtgaaatat 746461 ttaggtttat acaactacac catttatgac ggtgtacaga cggctcaaac agagacgcaa 746521 agagcctatg caagcagcga tgatttaaca agtgtcgaga attacacgac gtctcattat 746581 gcgaaaccaa acgccgagta cttcggctct gccaaaggca aaaatatcat taaaattcac 746641 ctcgaaagct tccagtcatt cctgattgac tacaagctaa acggtgaaga ggtgacgcct 746701 ttcttaaata aacttgcgca cggcggggaa gatgtgacgt attttgataa cttcttccat 746761 cagacaggcc agggaaaaac atctgatgcc gagctgacaa tggataactc gatcttcggt 746821 cttcctgaag gctccgcgtt tgtgacgaaa ggcgaaaaca cctaccagtc gcttcctgcg 746881 attttagacc agaaggaagg ctatacaagc gccgtcctgc atggtgatta caaatcgttc 746941 tggaaccgtg accagattta caaacatatc ggatatgaca agttcttcga cgcaagcacg 747001 tatgatatgt cagatgaaaa tgtgattaat atggggctta aggataagcc gttctttaca 747061 gaatcgattc caaagcttga atctcttaaa cagccatttt atgcgcattt gattacattg 747121 acaaaccatt atccgtttaa ccttgatgaa aaagacgcgt ctcttaaaaa agcgacaaca 747181 ggcgataaca cagttgacag ctacttccag acagcgcgtt accttgacga agcgcttgag 747241 caattcttca aggagctgaa ggaagccggc ctgtatgaca actcagtcat catgatttac 747301 ggtgaccata acggtatttc tgaaaaccat aaccgagcga tgaaagagat tcttggaaaa 747361 gagatcacag attatcaaaa cgcacagaac cagcgtgtgc cgctgatgat ccgcgttcct 747421 ggcaaaaaag gcggagtgaa ccatacgtat ggcggcgaaa ttgacgtcat gccgacactt 747481 ctgcacttag aaggaattga ttctcagaaa tatatcaact ttggtactga tttattctct 747541 aaagaccacg acgatacggt ggcattcaga aacggagact tcgtaacgcc gaagtacaca 747601 tcagtcgaca atatcattta cgatacgaag acaggtgaaa aactgaaagc gaatgaagaa 747661 acgaagaatc tgaaaacaag agtgaaccag cagctgagcc tttcagacag tgtcctgtac 747721 aaagacttgc tgaggttcca taaactaaat gatttcaaag ccgttgatcc gtcagactat 747781 cattacggca aggagaaaga aatcaaataa gatgaaaaag agccttgagc gggcgcattg 747841 ccttcgctca aggctctttt tttggttata caaccaactt gaaaaaatag attccatttg 747901 gtcaccaagg ctggctttct ctcatatcat tacagtagat tttgaaaccg gattgaaatc 747961 ggacaaatta tcggggaaat gccttgatag attgtgaaga tgtaccaggt ttcgaactca 748021 atattcatag agatgagggg tagagatgaa agcggtcatt ctctgcggcg gaaaaggaac 748081 gagaatgagt gaagtcacga atgacattcc taaaccgctc gccatgatag gcggcaaacc 748141 gattctatgg catattatga aaatttatca gtactacgga gtaaacgagt ttattctgct 748201 tttgggctat aaaggagaaa aaatcaagga atactttctc gactatgaat ggaagcacaa 748261 cagcctgaca ctcgacagct ctacgggaga ggtacagatg ctggggcagc ctgaaacgtg 748321 gaaaattacg tttttggaga ctggggtaga tacgctgaca gccggaagaa tcttgcaggc 748381 gaaagactat atcggtgatg aaacatttct gctcacctat ggagacgggc tggccaatat 748441 caatcttttc catctcatca gctatcatca gacaaaaggt gctgccgcga ctgtcaccgg 748501 cattgacaaa gtctcgcagt ttggcacctt gacagttgag gatggcatgg cgaaaacatt 748561 ttctgagaag acatcaagtg atggaatcat caacggcgga ttcttcgttc ttagtccaaa 748621 ggttttcgat tatttgccga aggacgggaa cacgatgttc gaagatgaac cgctgaagaa 748681 ccttgccaaa gatggggagc ttgctgtgta ccgccattac ggattttgga cggccatcga 748741 tacgtataaa aatctcttag aagtcaacaa aatgtggaat caaggacaac aagtatggaa 748801 ggtatggtga attgatttga gtttctggaa aaataaaaac gtatttgtca cgggatgcac 748861 aggtctttta ggaagctatt tggtgaaaga gctgatcgaa cagggcgcaa acgttacggg 748921 gctagtcagg gatcatgtgc ctcaatccaa tctttatcag ggagaacata tcaagaaaat 748981 gaacatcgtg cggggctctc ttgaggactt ggctgtgatt gaacgcgcgc ttggcgagta 749041 tgagatcgac acagtctttc atcttgctgc acaagcgatt gtcggcgtgg caaaccgcaa 749101 cccgatttct acctttgaag cgaatatcct cggcacctgg aatattctcg aagcctgccg 749161 caagcatccg ttaattaagc gggtcattgt cgcttcaagt gataaagctt acggcgatca 749221 agaaaacctt ccatacgatg aaaacatgcc gctgcaaggc aagcacccgt acgacgtctc 749281 aaaaagctgc gcagatctga tcagccacac ctattttcac acgtacgggc ttccggtctg 749341 cattacgcgc tgcggaaact tatacggcgg cggagatttg aacttcaacc gcatcattcc 749401 tcagacgatt cagcttgtgc tgaacgggga agcgccggaa atccgaagcg acggcacatt 749461 tgtacgggac tacttctata ttgaagacgc cgttcaggct tatctgcttc ttgcagaaaa 749521 aatggaagaa aacaatcttg ccggagaggc ctttaacttc agcaatgaga tccagctgac 749581 cgtacttgaa ctggtagaga aaatattaaa gaaaatgaac agtaatctga aacctaaggt 749641 gctgaatcag ggaagcaatg aaatcaaaca tcaatattta tccgcggaaa aagcaagaaa 749701 gctgctgaat tggacaccgg cctacactat tgatgaggga cttgaaaaaa cgattgagtg 749761 gtatacggaa ttcttcaaaa agtaatgtga aacgaggtga acaagactgt gaccagcgcg 749821 tattgcaccg ttttatcaaa aggaagatta tatcaggcag tcgctttgtt taagtcgtta 749881 gagcaagttg atcaagacag tcccattttt atactttgca tggatgaaga tacgcaccgc 749941 gtgttacaga agctgaagat gaagcagctg aaccttgtgc cggtggccgc tcttgaaaat 750001 gaattgctgc tgaagctgaa ggaaactaga gatcaaagtg agtattgctg gacgatgaag 750061 ccgatctttc tgcaagctgt gctgaacagc aatcctgagc tggagcgtgt gacgtatatt 750121 gacggggatc tctttttcta tgcagatcca tcgccgattt ttgaaaacca gccggactgc 750181 tcggtgttgc tttcacgagg ggatattgta atcccttctt ttgagaaaga gcagattgac 750241 atgctgcagc gtcttttagg cagatataat tccgggttta tcagcttcaa gcatgatgat 750301 gcaggcacgg attgcttgga gtggtggaag gaacgctgtc ttgaggaatg caaaaatgca 750361 ccgggtgaag ggaaattcgg tgatcagggc tatttggatt atatgtctga gctgtttccg 750421 aatgtgtgtg acattacaac acccggcgtg aacatcggcc attggaatta tggacagcat 750481 acgttttcct ggaaagatgg ccggatcgtg ctggaggatg gcagtccgct gatcttttat 750541 catttcagcg gataccgaat cgtcagcatc aatgaaatca aacagattca tgaaacaacc 750601 cgcacagatc tgccgtttgt gcatgaactg tatcaagaga cactgccgca tatcattcag 750661 cacatgcaaa cgttagaccc tgaatttaac ggttttgctt caaaagatga caacaaataa 750721 atgagtaaat acaggaagtg aaaatgaagt gaaagcaagc gttattattc ctgcatataa 750781 ttcgaaggag cgtctttaca acagccttct gtcattaaac cagcaggagt gcgatgaaga 750841 atttgaagtc attgtagcgg acaatggctc tgaggacggg acgctctcga tgcttgagtc 750901 atttcaagct gattttccgc tgatctttac acggattaaa gaaaacaggg gcattgcgta 750961 cggacgaaat caggcgcttc gcaatgccag aggagacatc ctgattttcc atgacagcga 751021 tatgcttgcg gcaaaggacc ttgtggcaaa acatattaaa gcccatgaga acgaagagaa 751081 tctcgtcgtg tgcgggttgt tttggaaacg gatctacagt ttttactatg aacgatttga 751141 agaagaacat aaggaacagc tcgcaaagct cacaggtgaa atgccgaaga aagacaaaca 751201 aaagctgctg gaggaagcgg acatcaaaaa cggaagcttt cttgataaaa gctttgacct 751261 cgataccgac tttatagacg tgctcaagaa gattttagat gagtacggcg atgacttgaa 751321 aggctatcat atgccatggc gcttttttat cacgaataat tcctctgtga aacgcaagca 751381 tgtggttgac ctcggtttat ttgacgaagg cattgtgcgg tacgggtttg aggattatga 751441 cctcgggatc aggcttcatc aggccggatt gaccttcagg cttcgccgtg atattgtcag 751501 tgttcatcag gaacatccaa gcaattgtaa gtctgtagac gatattcggg caaacattgc 751561 ctatatgtgc gataaataca ataacatccg ctccttagac gttcatctcg cttttaatgg 751621 gccgttcccg cctgacatga cgaacagaat catggctgat attcaaaagc tgctggaatc 751681 acagaaatat gatatgctgc tgaatctgtt tcttgagctt ctgcatgttg ttaaagagcg 751741 caacattgat ccggattggc gaaagaaatc cccaagggtg acggcgaaaa gctttgattt 751801 gcaaactgtc cgcaagcttc tgcctaaggc gaagaaaaag ctaggcgtga acgattttgc 751861 caacgcactg tatgcgcttg tcaacgattt gctgcacgtg gatcttagat cattggatgt 751921 ggtataagtg agtacatttc atttttcaac gatagtgtca aggacacata tctttaagct 751981 catgcctatg attcattctc tccatgagca ttgcgatgat tttcatttat atgtgctgtg 752041 tgtcgaccag aaagcgtatg aattgcttca gcacgttcca tgggagcatg taacctttgt 752101 gcagctgcat gaaatggaag acccggagct gttgaaagcg aaaagcaaca gaacgtttca 752161 tgaatattgc tggacgttaa agcccgcctt tttgtttcat gtgatgagca agtgggatga 752221 cgctgaatac tttgcccata tggatacgga tctatttttc ttttctgatc cggcacgtat 752281 ttttgcagaa aacccaacgg cgtctctgta tttgactgat catcgtaatt cgccgcgctt 752341 catgtcctac tacgaccgaa ccggacgctt taatacaggc tttgtcggcg ccggtaatac 752401 aaaggaagca tatgaagcgg tgtggcagtg gagacaggac tgtattgaat tttgcacggt 752461 cgaaatggat acggaacgaa agacatatgg tgatcaaaga tatgtggaga aatggccgga 752521 gcagtttaaa ggtgttcatg ttgtcaaatc cataggagcc aatacagcgc tttggaatat 752581 cgaaaactat aaggtcgggc aaaaggacgg ccgcgtgtat atagatgaaa cgccgctgat 752641 tttctatcat ttctctgggt ttacgctggt gacagaaaaa gagtttaatc tttgctggta 752701 ctaccggatt gaagacgaag cgacaattaa gatgatttat atgccctata tattaaatct 752761 gaaaagatgg attgatgaaa tacagtcggc gtttccggac tttgcggatg gctttatccc 752821 gaagcacgca gtgcctgaca ctcattttat ccagctggat taaaaaaccc cctgccgcct 752881 ggcaggggtt ttttcagcta tgccattctc tcagcttctg gtcacttggc aataggaagg 752941 caaggatgcc gaggacaggg agaaaggcaa tggcgatcat cgtcggggtc agtcccgcgg 753001 catcaatcag agcgcccagc gccacagcgc cgattgcgcc catcccgaag gcaagcccga 753061 cggttaaacc ggacattgtg ccgatttttc caggaactag ctcctgtgcg tagacgaccg 753121 ttacagaaaa gctcgacatc agaaccaagc caatcaatgc gagcacgccg taggcgagaa 753181 ccgggccggc aaatggcagc acaatcgcca gcggcgccga gcataacagc gaaccgagga 753241 taacgaagcg ttttccaaaa cggtctgcaa gcgggccgcc gagaaacgtg ccgatcgcgc 753301 cgaacagcaa gaagacaaaa atatagcttt gtgcctgctg aatgcttacg tgataggtat 753361 ccatcgcgta aaacgtgtaa aagttaccga tcgcactcgt ataccaagaa cgagcaaaaa 753421 tgagaaatat aataataata agagcagata caacagattt ggtgatggcc gtgttttcag 753481 ccgttttctt ttgcttgcct gatttctggg caaggctgcc gagacgtgag gcgtaccatt 753541 tcgcaatata catgagaaac ataacagcaa gcgcggcgac aagcgtgaac caaacagcgc 753601 cgaattgccc gagcggcaca aggatcagcg cggtgatcag cggtgccatc gcctggcctg 753661 agtttccgcc cacctgataa atcgattggg cgagcccgcg ttttgtgccg gcggccatat 753721 acgccacacg ggagccctcc ggatggaaaa tggccgagcc taatccaatg aaaaacacac 753781 agcataagat cgttatgaat gacggggcaa atgcaaggcc caaaatgcca agcatgctgg 753841 cggtcaaacc gactggcagc gcatacggcc gcggccgttt atcggtatac cagccgacaa 753901 caggctgcat gacggatgac accatgttta atgtgaaagc aatgatgccg agctgtgtaa 753961 acgtcaggct catggagcgt tccaaaatag ggaacatggc cggaatcaca gcctgaagcg 754021 aatcgttgag catatggcaa attccgataa taatcaaaat cggatacacc gtggtgcctg 754081 gtttttgaac tgttttttct tttaacgggg cggcgatagc cattgagtct cctccttaca 754141 tatataacca aagcatacca ccatattatt cataaggtga agaatttatc aagaggaaaa 754201 aagattctta tgaaagaaat accgtcagcc tgattagcag ctgacggtat tttcgatatt 754261 caaaatgtga tatagctctt caagcttacg aatctcatag gttggtatga tctctggcac 754321 attcggcttc atgtcagggt tcatccagca agtatcaagc ccggcgagct gtccgccttt 754381 gatatcagca gttagtgaat ccccgatgat taatgtgtgc tctgctgaaa attgaggaat 754441 ccgttcaaac acgtaattga aatattcctt catcggcttt tggaagccgg tgtcttcaga 754501 aacgaaaatg tccttgaaga atggaaataa tcctgaatca cggagacgct tatattgtgt 754561 gtgagacacg ccgtttgtca cgatgtacaa atcaaactgt tgctgcagat ttgagatgag 754621 atcaaatgca ccgtcaataa gctgatgtcc ttcttcaaga aagcggcggt atttttgctc 754681 aagcaaagcg ccgtccgctt cgtaaccgta ctccttgagc aaagcggaaa aacgtgtgtt 754741 tacgacttca tcccgtgtca tcttaccttc ttcaaaggct ctccagagac cttgattgat 754801 ggttttatac tgcgccttca tgtcatttgt taaaggaatg ttctgatctt caaacagcaa 754861 acgcagggct aaagcttctg ccgcttgaaa atcaaggatg gtatcatcta catcaaataa 754921 taaagtgcgg tatcgcttca tctgtgtgtc tccctttctc atatgtattc aaagtatagc 754981 acataaaaaa aggaaaaagc cggcgggtga ggcaccgccg gctgaaaaga gattatttgt 755041 ttaataagct gtgttttctc gaatatagga agtaaaccag cgttccgaca gcgatccaga 755101 tgacaaatga aagccatgtg acgccgggaa ggctgtacat gaaccaaagg cagatgcctg 755161 cgctgataat cggcacaacc ggaacgaatg gcactctgaa ggacgctttg atttcaggat 755221 gtttctttct taacacaatg acagcaatgg aaatgaccgt aaacgcggca agtgttccca 755281 tgttcaccag atgggccagc gttccgaggt taataaagcc ggcgattccc gctgcaacga 755341 tccctgtcag ccatgtgttg cggaacgggg ttttaaatga cggatgaacc tttgcgaaca 755401 atccaggcag aaggccgtct ctgctcatgg caaatgtcaa gcggacctgt gcgtacagca 755461 aagcgagcat caccgtcgta atcccgataa tcgcaccgac agaaataatt ccggcaacag 755521 cgtcctgtcc gacgaatttc agcgcaaagg atacaggatc tccgacattc aatttggcat 755581 aaggcatcat gcctgtcagc acaagcgata ccgcgatgta cagaaccgta cagacggcta 755641 gagctgaaat aatgccgacg ggcatgtttt tttgcggatt tttcacttcc tctgatgcgt 755701 tagaaaccgc gtcaaaccca aggtacgcga agaatacagt ggcagcgcta agtatgacgc 755761 ctttcatccc gaatggcata aaaggagacc agttatccgg tttcacatag ccgatgccga 755821 caataatgaa caataatatg atcgcgattt tcatcagtac gatgacgttg ttaaagcgtg 755881 tgctttcctt gacgcctctg ctgacaatcg cagtgatgag gagaatgatc accgcagccg 755941 gaaggttaaa tacggcgccc gccatgcttc ccggcgctcc tgtcagtgca gccggaatat 756001 gaagattgaa gccggcaagc agtgattgaa agtatgaaga ccagccggtg gcaaccgccg 756061 acagtgcaat gacatattca agcatgagat cccatccgat caaaaaggcg agcagctctc 756121 caagtgtcac gtatgagtat gagtacacgc ttcccgaaat cggaatggaa gacgaaaact 756181 cagcataaca gaaagcagcc agcgcacagg cgagccccgc taaaataaac gatatgatga 756241 gggcgggacc tgcaccggtc gctgccactg ttcctgtaat gacaaaaatc cctgtaccga 756301 tgacacaacc gataccgagc aaggttaaat caaatgcgct taacgtacgg gcaaggcttt 756361 ttgacttgct ctgcgcactc aatgtttcaa gcggtttttt tctaaataat gaactcatca 756421 aaagttcctc ctagaaatat tcaaaatatt ctaatcatta tatgcagttc ttgttgtatt 756481 atattgtcga aatttgacgt agtcaataaa atatttttct gctttaaatg atagaagcga 756541 aacagcgttg tcgtatcata ggatagtaat ttttactaat cgtatattca attttatgca 756601 agatgaaccg atagaaaaaa tagattcgcc catattttga tttgcggtta taaaggagat 756661 gctgaccatg tttcaatatg aagagttgaa taaacagttt atcggcggga aatggcagga 756721 gggcagcagc ccaaatgtat tggaaaacaa aaatccttat actcaaaaaa cattcacaac 756781 attccgtaaa gcgactgctg acgatgtaga tgaagcgtat cgggcagcgg cgctggcaaa 756841 gaaaaaatgg gatgcggtca acccgttcga gaaaagaacc attttagaaa aagccgtcac 756901 gtatattgaa gaaaatgaag aagccattat ttatttgatt atggaggagc taggcggtac 756961 aaggctcaaa gcagcttttg aaatcggtct tgtcaaaaac atcataaaag aagcggcaac 757021 gttcccaatc cgcatggagg ggaaaattct tccgtcaaca atagatggca aggaaaacag 757081 attatatcgc gtgccggcag gcgttgtcgg tgtcatcagt ccgtttaact tcccattctt 757141 tttatctatg aaatcagtgg cgcctgcact cggagccggc aatggcgttg tgctaaagcc 757201 gcatgaggaa acgccgattt gcggcggaac gctgattgcg aaaatttttg agaacgcggg 757261 aattccagcg gggctgctga atgttgttgt cacagacatt gctgaaatcg gcgacagctt 757321 cgttgagcat ccagtgccgc ggatcatctc atttaccggt tctacgaaag tcggcagcta 757381 catcggacag cttgcgatga agcattttaa aaagccgctt cttgagcttg gcgggaacag 757441 cgccttcatc gtacttgagg atgcagatat agaatatgcg gtcaatgcgg cggtgttcag 757501 ccgatttaca catcaagggc agatttgcat gtcagccaac cgcgtgcttg ttcattcttc 757561 tatttatgac aagttccttg agctgtacca ggcaaaagtg gaatcgctga aagtcggcga 757621 cccaatggac cctgatacga ttatcgggcc attaatcaac agcagacaga cggacgggct 757681 gatgaagact gtagagcaag caattgaaga aggcgctgta ccagtgaagc ttggcggatt 757741 taacgggacg atcgtggaac cgacgatctt aaaagacgtc aaaccgttca tgagcattgc 757801 caaggaagag ctgttcggac cagtcgtctc ctttatgaag tttgattcag aagacgaagc 757861 ggtggatatc gcaaacgaaa ccccgtttgg cttgagcggt gccgtacata cgtcaaatct 757921 tgagcgcggc gtggcttttg cgaaacgcat tgaaacaggc atgattcacg tcaatgacac 757981 gaccatcaat gatgaaccga atgtagcctt cggcggtgaa aagcaatcag gcctcggccg 758041 tttaaacggt gagtggagcc tcgaagaatt tacaacgctg aaatggatct cggtccagca 758101 cgaaaaacgc agcttccctt attaatgaaa aggagtgaat ggaattgacc ataaatacgg 758161 aaaaagaaac cgcagatatt ctggacgcat ttatcaaagt agccccttat ttaaacagcc 758221 tggttcagga tgatattaca atcggcattt atgatacgga aaaactgctc gtgaatatac 758281 cggccaaaac cttttcgctg aacgtaaaag ccggcgatcc gctgcaggaa ggggatatca 758341 tcacagatgc catccgcagc aatcagaaga agacgagcat ggttccgaaa gaattgttcg 758401 gcttcccatt gatcgcgcgt gccatcccgc tgcacgacga gaatggaaga gtcattggag 758461 gcgtcggcct cggaacgagc cttgaggagt cgtcaaagct gcatgatgtc gcggaaagct 758521 tatcagctgt tgttgaacaa acagccgcgg ctatttccga catttctgaa tcaattaacg 758581 ggttttcaac tcaaatgtcg ggcatttcct ctcaggcgaa aaaagtaagc gaaagcgccg 758641 gtgaaatcgc cgatatttca gtaactgtta aaggcatctc ggaccaaagc aatctgctcg 758701 gcttgaacgc cgcgatcgaa gcggcaagag caggggagtc cggaaaagga ttctctgtcg 758761 tcgcagatga gatcagaaag ctagcgacgc attcaaaaga aaatgtcggc caaattgacc 758821 agattacgaa aaaaatccac agcctgctga aagggctgga ggaatccatt gagtcgatta 758881 accagcatac agacggacaa gccgctgctg ttgaacaaat ttccgccacg atgcaggaga 758941 tttcaggaag cgcgcagcat cttgcgaaaa tggccgaaaa agcgcttgag gaagagtaag 759001 agaccgggga caaacatccc cggtcttttt cttatcctgc atttccatga aattcgtctg 759061 acgttttact agttttattc cagcggctga tttaaaatgt acacatgaac ttacgtgagg 759121 attgatagga accatgagca tattaaaagc ggaaaatctt tataaaacat acggagataa 759181 aacattattt gaccatatct cctttcatat tgaagagaat gagagaatcg gattaatcgg 759241 gccgaacgga acaggaaaat caacgctgtt gaaagtgatt gccggcttgg aatctatcga 759301 agaaggagaa atcacgaaat ccggaagcgt gcaggtcgaa tttcttcatc aagacccgga 759361 gctgcctgcg gggcaaacag tgctggagca tatctattcc ggtgaatcgg ctgtgatgaa 759421 aaccttgcgt gaatatgaaa aagcgctgta tgaactgggg aaagatcccg aaaatgaaca 759481 gcgccagaaa cacctgctgg cagcacaagc gaaaatggac gcgaacaatg catgggatgc 759541 aaacaccttg gcaaaaaccg tattgtctaa gctgggcgtc aacgacgtaa caaaaccggt 759601 caatgagctc tcaggcggcc agaaaaaacg ggtggccatt gccaaaaact taattcagcc 759661 cgctgatttg ctcattttgg acgagccgac aaaccatttg gataatgaaa cgattgagtg 759721 gcttgaaggg tatttaagcc aatatcccgg cgccgtcatg ctggtgacgc acgatagata 759781 tttcttaaac cgtgtcacca accgcattta tgagcttgaa agaggcagcc tctacactta 759841 caaaggcaac tatgaagtgt ttttagaaaa acgcgcggaa cgggaagcgc aggctgagca 759901 aaaggaaacg aagcggcaaa acctgctgcg ccgcgaactg gcttggctca gacgaggagc 759961 gaaagcccgc tccacaaaac aaaaagcgag aattgaccgg gtagagacgc ttaaagagca 760021 gacaggccct cagtcatcag gttcactcga ttttgccatt ggctcgcacc gtctcggaaa 760081 acaggttatt gaagcggaga acgtcatgat cgcttatgac ggccgcatgc tcgtcgaccg 760141 ttttaatgaa cttgtcatac caggtgaacg gatcgggatc atcgggccga acggcatcgg 760201 gaaaacaacg ctgttaaatg cccttgccgg ccgtcatacg ccggacggag gcgatattac 760261 gatcggacag acggtcagaa tcggctacta tactcaggat catagtgaaa tgaacggtga 760321 gttaaaagtc attgactata taaaagaaac ggcggaggtc gtaaaaacgg cagatggcga 760381 tatgattaca gctgaacaaa tgctcgagcg tttcctcttc ccgcgttcga tgcagcagac 760441 gtatatccgc aagctgtccg gcggggaaaa acgccgttta tacttgcttc aggttctcat 760501 gcaggagccg aatgtcctgt ttctcgatga gccgacgaac gatttggata ctgaaacatt 760561 aagcgttctt gaggattata ttgaccagtt cccaggcgtc gtcatcaccg tatcccatga 760621 ccgctatttc cttgaccgcg tcgtcgaccg tttgattgta tttgaaggaa atggtgtcat 760681 ttcccgcttt caaggctcct atagcgacta tatggaggag tcaaaagcga aaaaagcggc 760741 cccaaaaccg gcagctgagg aaaaaacggc tgaagccgag ccgaagaaaa aacggaaaaa 760801 gctttcttac aaagaccagt tggaatggga cggcatcgaa gataaaattg cccagctgga 760861 agaaaagcat gaacagcttg aagctgacat cgccgcagca ggcagtgatt ttggcaaaat 760921 ccaagagctg atggccgagc aggcgaaaac ggcggaagag cttgaggctg cgatggaccg 760981 ctggacagaa ttgtccctca tgatcgaaga actggaaagc taaaaagcgt ggccgcagca 761041 ggccgcgctt tttttcacat aatggacaaa aacgaaccgg cctgcttatg ttaggataaa 761101 gttgtgtgtc agcggcacat ggaaaactaa cggagatgat gaagtatgac atgggcgatc 761161 gtgatgttaa ttctcatgag tctggtgaaa atcgtattaa cctgtcttcc tacaggcgtc 761221 atagaatggc tgctcggcaa atttgaagtg cacgccaagc tgagtgacga aaatgcgagt 761281 ctctctctag atggaaaacg cctcgagggt gcagagaagc agaaagtgat tgatcaattt 761341 aacgaagcta tcttcctgga aaaatattat atctatccag gtgatgaaga gcgttattta 761401 catccggaaa acggcggcac gcctctggtg atagatacaa aaaaaggaaa aaaagacgtg 761461 aagctgttcg tgtaccgcta cgacgaccat atcgacgtcg tgaaacagta caagaagaaa 761521 gtgatcgcgt atcgagtgct ttctgaaagc cttcaaaaag agtctctgtc agtggcggga 761581 agtttagctt aaacaggaaa gtgaaagacg ggtgctgtat gctgctcgtc ttttttattg 761641 ttttttaaaa cttaacgttt acgttaaggt tcaaaaggtg tataatggta acagaaacgg 761701 cgaaggggga tttaccttgg aatggatgaa gattgatcaa gtggccaaaa gaagcgggct 761761 gacaaagcgg accatccggt tttatgaaga aatcggcttg attccggcgc cgaaacggac 761821 agacggcggt gtaaggcttt attcagagga tgatatggag gagcttgaga aagtcatcag 761881 cacaaaagag gtgctcggtt tttcccttca ggagcttcag catttcatgg aaaccagccg 761941 ccagctagag ttaaacaaag aggggtattt gttgtcactg gatcctaagg aacggaaaga 762001 aaaactggag gaaattcagg aaaccctgaa tcaccagctg gatttgattg atgagaaaat 762061 ccgcacattc caaagcttta aagaacgcct gcagggcatg aaaggcaaag cggaacgcgc 762121 cattcaatca atcgaatgaa aagtttgtta aacgctattt ttgtagcgtt tcttttaatg 762181 gaataaagat ggaggttagg tcaaatggat aagacaacac aagtgaatca gaaaacgggt 762241 ttgctcagcc agccaaaagc ggtatgggct gtcgcgtttg cctgtgtgat ttcttttatg 762301 ggaatcgggc tggtcgatcc aattcttccg gccattgccg cacaattgca tgcttcacct 762361 agtgaagtat cactcttgtt tacaagttat ttgcttgtaa ccggatttat gatgtttttc 762421 tcaggagcca tttccagccg catcggcgcg aaatggacat taattctcgg acttattttt 762481 attattgtgt ttgcggggct tggcggcagc tcaagctcaa tcgctcagtt agtcggctat 762541 cgcggcggct ggggattagg gaatgctttg tttatttcaa cagcgcttgc ggtcatcgtt 762601 ggcgtgtcag tcggcggcag cgcccaagcg attattttgt atgaggccgc gctcggtctc 762661 gggatttctg tcgggccgct tgcaggcgga gagctcggaa gcatttcatg gcgcgcaccg 762721 ttttttggag tatctgtcct gatgtttatt gcgttaatcg cgatttcttt catgcttccg 762781 aagctgccga aaccggcgaa acgcgtcggt gtgtttgatg cgatgaaggc actcaaatat 762841 aaaggcctgc tgacaatggc ggtatcggca ttcctataca actttggatt ttttattttg 762901 ctagcttatt ctccgttcgt actggattta gatgaacacg gtcttggata tgtcttcttc 762961 ggctggggcc ttctgctggc gattacgtca gtctttacgg cgccgctcgt gcacaaagcg 763021 ctgggcacag tgcgttcgct agtcgttctc tttatcgcct ttgcggccat tctcgttatt 763081 atggggatct ggacagacca tcagactttg attattacat gtatcgttgt cgctggtgct 763141 gtcctcggta tggtgaatac gatcatgaca accgctgtga tgggttctgc gccggttgaa 763201 cgttcaatcg cgtcttcagc ctacagctca gtccgcttca tcggcggcgc gctcgccccg 763261 tggattgcag gaatgctgtc agaacacttt actgcaagca caccatatac agtaggcgga 763321 atcgtcgttt ttgtcggcat gcttgtcctt ctcatgggac gtaaacatct tgctggaatt 763381 aaggcggggc attaataacg aaagacactg cgcatatgca gtgtcttttt attcgttata 763441 atgcatcata atcgaattgg tgcaggaaag gacaaccttt atgacacaat tttactattt 763501 tccggctgaa aactcccttt agaaaccggt tttttcggtc agcaagaacg gcgttcgcgg 763561 aaagggcatc cgcttcggtc aggcattgat gcggctggga tttatcttgc agaagctgag 763621 aatgtgtccg ttcatttacg attgccattt cagtgatggt tcatgctgta gaggggacgt 763681 ttgccatgga taaggcaaaa cctgacgaat atgatcagaa atgtttagaa acgctctatc 763741 aatacataca cagcgtcatg aaaaacagct tttctcggtc gagtggttta ccgcttggga 763801 agatgaggag gattttgagc tgtctgccaa aagagagctg acacttgatg aattcacatc 763861 tccattgcag ctcattttaa aagacagaga gcttttgaga atcgttcaga aaaaatggca 763921 gtaaaaaacc cgccctttag caggcgggtt tttttataaa ttaaagcact ttcgtcgtcc 763981 aagactcgca gttccacgtt tctgtcgcaa tatccatata aaagtctggc tcgtgggaaa 764041 tgagcagaat ggagccttta tattctttca gggcgcgctt gagctcttcc ttggcatcgg 764101 catccaagtg gtttgtcggc tcatcgagca ccagcaggtt tgtttctgag ttgattagct 764161 tgcacaatct gactttcgct ttttcgcctc cgcttaatac ggagacgcgg ctttcgatat 764221 gctttgtcgt cagcccgcat tttgccagag cggcacggat ttcatactgc gtataagaag 764281 ggaattcgct ccatacttct tcgatgcacg tattgttgtt tgtttccttg acctcttgct 764341 cgaaatagcc ggtatagatg tgctcaccgc gttcaacaga gccttcgagc ggctggattt 764401 caccaagcaa acttttcagc aatgtcgttt ttccgatccc attcgcgccg taaagggcga 764461 ttttttggcc gcgctccatg cggaggttga gcggacggga cagcggggaa tcgtaaccga 764521 tcacgagatc cttcgtttca aaaatcagct tgcctgacgt tctcgccggc ttaaagtgga 764581 attccggctt tggcttttct gccgcaagct cgatcatatc catcttatcg agtttctttt 764641 ggcgggacat cgccatgttt ctcgtgctga cacgcgcttt gttgcgggcg acgaaatcct 764701 tcagctccgc gacttcctgc tgctgctttt tgtaggccgc ttcaagctgc tgttttttca 764761 cctcgtagac ttccataaac tgatggtagt cgccgacata acgtgtcagc tcttgatttt 764821 caacgtgata aatcaggttg atgacactat tcaagaacgg aatatcgtgg gaaatcagga 764881 tgaacgcgtt ctcgtattcc tgcaggtagc gtttcagcca ttcaatatgc tgttcatcaa 764941 gatagttggt cggctcatcg agaagcagaa tttccggctt ttcaaggaga agcttagcga 765001 gaaggacctt tgtgcgctgt ccgccgctca aatcggtgac atctcgctct aaaccgatat 765061 cgctcaaacc gagaccgcgg gcgatttctt ccaccttgga atcaatgaca taaaaatcat 765121 tgtttgtcag cgcgtcttga atgacgccga cttcttcaag cagcttctcg agctcgtcgg 765181 gatcagcctc gcccattttg ttgtaaatct cgttcatttc ctcttccatc gcaaataaat 765241 aatggaatgc gtctttcagg acgtcgcgaa tggattttcc tttttccagc acggtatgct 765301 gatcaaggta tccgacacgg acattttttg accattcgac ttttccctca tcaggttcaa 765361 gctttccggt aataatattc atgaaggttg attttccttc accgtttgcg ccgatcaagc 765421 cgacgtgctc gccttttaac aggcggaagg aaacgttatt aaaaatggcc cggtccccga 765481 aaccgtggct taaatccttt acagataaaa tactcatgtt tacacctcta tcgttatcaa 765541 acacgcacaa tcggcgtgta atattcaccc ttttgattat aaaggaggat tcggaatgtt 765601 gaaaggtata ggaaagaaaa agaaaaattg cgttccgggc gaggttttga gatactatgg 765661 aatagatttc aggaattgag gagaacaaaa tgacgcaaac ttggccattt ttacataatg 765721 cacaatcatt tatacaagag aattggaatg cttccggctt tcaaaagcca acccctgttc 765781 aggagcaggc agcccagctg atcatggacg gaaaggatgt cattgcagaa tcgccgacag 765841 gcacagggaa gacgctggcg tatgcgctgc cggtcttgga gcggatcaaa ccagagcaaa 765901 agcatccgca ggcggtgatt ttagcgcctt cccgtgagct ggtcatgcag atttttcagg 765961 tgattcagga ttggaaagcg ggctcagagc tgcgcgcggc ttccttaatc ggcggggcga 766021 atgtgaagaa acaggtcgaa aagctgaaga aacatccgca tatcatcgtc ggcacgccag 766081 gcagggtgtt tgaactgatt aaagcgaaga aactcaaaat gcatgaagtg aaaacgatcg 766141 tgcttgatga aacggatcag ctcgtcctgc cggagcatcg cgaaacgatg aagcaaatca 766201 ttaaaacaac attaagagac cgccagcttc tatgtttttc tgccacgctc aaaaaggaaa 766261 cagaggacgt gctccgcgaa ttggcgcaag agcctgaggt gttgaaggtg cagcgaagca 766321 aggcggaggc agggaaagtg aagcatcaat acctgatttg cgaccagcgc gacaaagtga 766381 agctgctgca aaagctgtca aggcttgaag gcatgcaggc actcgtattt gtgagagaca 766441 ttggcaacct gagtgtatat gcggaaaaac tggcatatca ccacgttgaa ctcggcgttt 766501 tgcacagtga agcgaaaaaa atggagcgag cgaaaatcat tgccacattc gaagacggag 766561 agtttcctct tttattggcg actgacattg ccgcacgcgg tttagatatt gaaaacctgc 766621 catacgtgat tcatgctgat attccagatg aagatggcta tgtccacaga tcaggacgaa 766681 caggccgggc cggaaaagaa ggcaacgtgc tgagccttgt gacaaaattg gaggaatcta 766741 agctgaaaaa aatggcgaag aagcttggtg ttgagctgag tgaagctgtg tatgcaggcg 766801 gaaaactgaa gacgaaataa aaagaagggc gaagagccct ttttttgttg taaaataata 766861 gaaaagattt tgcgcggagg tgggaaaatg gcttcaatag acaggtttca agtaatgcag 766921 gagccagagc tgaaaatcct tgaacactgg tttgagaatg aggataccag acggagaatg 766981 gatgggatgc tgctattaga tgagtggtat gcacgagtaa ataaagataa acacgatact 767041 gtcatcatgg cgtatgatgg acagctgccg gcagggatgg tcgttattga gttcggagag 767101 gagcggacat atattggatt gatcgtcaat cctttgtacc ggcttaaagg gtatggaaaa 767161 cagatactgc aaaagctgat gaccgaacct gattttacta gcgtgcgaga atgggtggca 767221 tgcattgaag aagacaatcg aatcagttta gcttgctttc aagcagcagg attcacttta 767281 gaagacacgg aacctgatga agatggtttt cttacgctga ttcttcgcaa ctgatctcat 767341 cgaaacacaa aaggagggca aaaagccctc ccgttttcat cttcattcag ctcggatcac 767401 tgaccttgat cagctgtttc cctttatttt ctcccttaaa taaaccgaga aacgcgtcag 767461 gaatgttttc gaagccttct gtgatggttt cctcgtaatg gagtttacca gccttcagcc 767521 attctgccag ctgttttgct ccctcagaaa aacgatcgga gtagtcgctt acgataaagc 767581 cttgcatcag cgacttcgtt ttaatgagtt ttgattggac acgagggccc atgtcatctg 767641 cttcgctttc tgcgttatag gaagaaatgg cgccgcacac cggaatgcgg gcaaattcat 767701 tgagcagatt catcaccgcg tctgaaatcg gtccgccgac attgtcaaaa tacacatcga 767761 caccgtcagg acaagcgttt tgaagcgctt tttggatatc atccgctgtt ttgtaattga 767821 tggcttcgtc aaactgaagc tcctgtttta aatagtcgat tttttcatca gagcccgcga 767881 tgccgacgac tcgcgcgcct ttgattttgg caatttgccc gactgttgaa ccgacggctc 767941 cggcagctcc tgagacaacc acggtttcgc cttccttcgg gcgtccgatg tccagcaatc 768001 cgaagtatgc tgttaagccg gtcattccca aaatgccgag ataggccgaa gcgggagcaa 768061 ggcttgtatc aatttttcgc aaggcagact cgctcacagc ggaaaattcc tgccagctga 768121 gatttccgat gacgatatcg ccttttttca gatgattccc gtctgacaca acttcagcga 768181 taacccctcc agaaagcgct ttatccaagg cgaacggctc aacatatgac ttcgtatcct 768241 gcatacggcc gcgcatataa gggtcaaccg atacataaag cgttttgaca agcacttccc 768301 cttgcttggg ttcaggaacc ggaatggttt caaagcgaaa gtcttcatga acaggaatac 768361 cttgtggacg tcttgctaat tgaatttgct gctgagatgc tgtcattttc atcctcctat 768421 cacttggttg acaccactgt aacatggaca ggagaggaaa tacaaaaggt aagctggcat 768481 acaaaaaagg ttatagatga gcttatgctt tctacaagct cttttgtttt aaaagttctc 768541 tttagtcatt tatcattatt agaaaacaga acagaaaaag agctcctgta cacctagcta 768601 agattggcta gtgtgtatgt cgattctttt tcatattctt gcaagcatct gcgaggggga 768661 gcttagtcgt tcacattttg ctttcgcatc aatctgcaat agcaaagtct atgcgatttt 768721 tttacatcag caaagatttg ttcaattttt tccttttatg ccgagttttt ctgaaacaga 768781 taattgatgg tactcaacca ttttcttttg gtcaataaag taatgtttac ttattaatta 768841 aacacgcgaa aaagcaaacg aaaacataat taaattttat atatttatta aaagcttata 768901 tgtttattta cctttttttt gaattgtaat tgagaaaatc catatattgc ggacactaat 768961 aaaagaatac ctgctgaaac ataaactaaa cgaactccaa ggaaatctga aatagcccct 769021 atagccagaa ttgaaaacat aaaaatgaac tgtactaaag aagaccttgc agacattata 769081 ttaattcgag tttgctcggt tgttatgttc tgaataagtg tttcttgtgt aagatctctt 769141 aatatataag ccggccccat aaagagaacc aaaattagag ctaagtatga attacttata 769201 aaaccatata ttaaagttaa acttccatat gagacagcgc caattaacat aaaattaatt 769261 aacttatttt gaaatctctc cgacagctta tatattataa atccccctat catcgaacct 769321 aaataatatg ctccattaat aaatccccac catgattctc ctttatgcaa gacttcgtta 769381 acgaaagcta aagagacaga tcctatccaa atcattcctg cccatgactc aattaaatcc 769441 ataataataa ttgttctaag tttcttttgg ctaaataaat accgccaacc acttactata 769501 ctcttattgg gagaattttt ttcacgtatg acagaattag cgtggccatg tggtagacaa 769561 aataaaagag aaagaagaga tgtaaacaac aaaaagatag taagtataat ggtatatccc 769621 tcacctaaaa atgcaattat gagaccacct aaagaccagc ctacaaattg aaaagtttgg 769681 tccactgtag ataataatcc atttgctttt actcttctat caggagagat tatttcccct 769741 ataattgcac tttttaaagg tgagaaccat ccattaaaaa aggaaataca gctaataata 769801 ataaagacta aaatgagagt ttgattagag taagttctta ataaagcata gaacaaacat 769861 attaataaca gcatttgtat caattgagaa ataattattg taagaggcag ttttaatcga 769921 attgttatta acggtaatat agcacttcca aaaatacgaa aaataatact tattaatgtc 769981 accatagagg cgatggttgt cgaattggtc attttaaaca aaaacgaaat cactaccata 770041 gtatatagag aaaaacctaa atttgtagtg gtctggctaa ataaaataga ataataacct 770101 ttactcatat gtatcctccc ttggaataat ttttctcggt aaagagctta aacatattta 770161 aacaccttaa aacaacaaaa gtaaagaaaa aatttccttg taaactattt acttttattc 770221 tatttattgt tattgtttat ttaagttctc tgactattct atcaatattc agggaaccac 770281 atatcttatt aaagggggga aaaccatgag aaaattaaga aaaaactgga gaaaatcgat 770341 tgttagcccg gttctttata ctaatgaaaa atggtaaaca cttagggaat agcatttaat 770401 gctattcctt atttcaacaa acaaatcggg aggttatcgt aatttgactc tattaatgca 770461 agatcataaa tcaatttaca ataaagatat agaaatatta attgaagttg aagaacttat 770521 tacttctgtt ccagaaaata aaaaaaatga ttttaagagt ttaatcgata atagaattat 770581 gactctacta aataaaattc aacaccctgt agcagcggaa aatgtgtttg ggatgtgtat 770641 tgcttatccg aatacttaca taaggtatag attaattgat ttcgttgaaa aatgggtacc 770701 ttatttctct gctgtagaaa ctataatcaa tctaacccag gatccggatg atttagtttc 770761 ttttaaagct atggatgtct gtgcaaatca taaaattgaa gaatctgtag catatttgtc 770821 ttcgattatt gatgatgtcc gggagagtat aagctaccct aaaaaacctg tgggattagg 770881 ggcccaaaaa gtattaagta cattattaga tatattcggt gttgaaaaac atgaagagct 770941 agtaatgcta aaaaattatt ttgatcaaaa tggtatactt cctaataact ttgactttga 771001 agaaaaaatt cctcaaagtc taatagagga attcgaaaaa acagaagaag atgggatgat 771061 tttaattccg ggtggctttt ttgaattcgg tttaaatgaa aatgaaattc ctgacaaaac 771121 atttaattgg aaagatgctg ttcctagaca aaaagtatgg ttacctccat tttttatcga 771181 taagtatcct gttacaaata aagattatga tatctttacc gagttcatag aggaaaatgg 771241 gcatatattc tgtcatccta atgaaccgca gaataaacaa catagaagaa atacatattg 771301 ggatgatagg tatttagata atcatcccgt tacaggtata gatttttatg atgcatttgc 771361 ttacgcaaga tataagggga aagaattgcc aaccgagttt caatgggaaa aagctgctcg 771421 aggcgaaaag ggtaatgtct ggccttgggg agataaattt gatcctgcaa aggttcaata 771481 tgctggaagt ctttataatg aacccattac ttctttaaag tcctggagag aaaatttatt 771541 aaaagctcat gctgataaag aattaaatca tttaacaagt gatatttttg aacaaaatgg 771601 tgaaagtccc tatggagtat gcggtatgat cggcggaaca tgggagtgga ctagaagtga 771661 gcttaaaaca aagagagctt tccaccctat ttttgagaat gtaccattta atagtgttaa 771721 ctcatttgcc gttcttaaag gaggatcatt cttctctcat ccaggcttaa tgttcccttc 771781 ttttagagca aaagatattc ctttctgtcg acacaatgaa atggggatta gatgcgtaaa 771841 gaatattcca gtatataaaa ttagagaatc aattaatggg ccaattacta ataaagcaat 771901 ttattaatca ttctaggtta gagacttgat aaaagtatac taacattgtg tagtaatgtt 771961 cagcttgtag aaaaaacaat gttttttcta caagatttta ttttaaatgc ttttcaaaat 772021 tatcagggat tgagaatcag aaaaagagcc attaagctcg atcttagcta ggtattacga 772081 tcttctgtat attattgtga gaaatataga agattcagtt agttagcatt tcgattttaa 772141 gctgagcctg caatagcaaa gcatctgttt tgattattct ttttctgata cataagctaa 772201 ttttgtcgct tttctttttt gtcttttcac gcatttcgag gatgacttac tataattctt 772261 tcagcttttc tatgtgttaa gattcgaata gatgaaataa ctttaacaag ttggtcaata 772321 agaacagatt taactttatg ttaaaagagt atctcgtata gaacataaga agaatgacga 772381 gttttttaag attatcatca attatgtgag aataaaatat tataagggaa aatgaaggct 772441 gtcacgtttc tcgacagccc tagggaattc ctctcctttt catttcgccc gtaatttcgg 772501 gcacagtccc gtcggcaggc acattggctt ctggtcgatc gggcttctca tgatgcagca 772561 ttccaagccg aagacttcac ggaaaaatgg ctgggtgaac acatcttccg gtgttccggc 772621 gttgtatatt tttccgtcca gcacactgat cagatagtca gcatattgag cggcttggtt 772681 taaatcatgg agcaccatga caacggtgcg gccatggtcg cggttcagct ttttcagcag 772741 ttcaagcact tcaatctgat gtgagatgtc taaatacgtg gtcggctcat caagcaaaag 772801 caaatcagtg ccttgcgcaa gtgccatgga aatccaggct ctttgtcttt ggccgcctga 772861 gagggcatca agtgtccgat ccttcagttc aatcatgccc gttgcttcca gcgcccactc 772921 taccatgtca tgatcctctt gggtatgctt ggataacagc tttttgtgag gatgtctgcc 772981 aaaatagcat aattcctcta ccgtcaatcc ttcaggagcc tgaggagatt gtggaagaat 773041 ggccagtttt tttgcgactt cttttgatgg ctggcggtgg atgtcttttc cttctagtag 773101 cactgtaccg ctttttgggg ccatcagcct ggcgagcgat ttgaggattg ttgatttacc 773161 gcagccatta gcgccgatga gcgcagtgat ttttccttct tctatcttta agtcgactcc 773221 gtcaataatc actgtactgt catatgaaag agtgagctgg tctgcagcca gttttcccat 773281 ggtatcctct ccctactgtt tcctcgcttc gaatttcaat aaatataaga aataaggcgc 773341 gccgatcacg gctgtcagta ttccggcagg tatttcaacc ggaggcatga tgccgcgccc 773401 taacgtatct gcaattaata atataatagc accaatcaat gccgatgcag gcagtaaata 773461 tttagctttt tctccggtaa gccgtctggc gatatgcgga gcaagcaagc cgataaaacc 773521 gattgagccg acgacggcta cacagcttcc cgccagcgcc accgcggtga aaatcaggat 773581 gaatctcagc cggtttgcgt tttctccgag accctgtgca agctcatccc cgagtgacat 773641 aagatccagc ttcggtatga gtatgcagac gatcggaaaa agaatcaaaa gccatggcgc 773701 aagcagcttg acttcttccc agtttcttcc ccagaggctt cctgtcagcc aaatgagtgc 773761 agcattcacg tcgcctggaa acttgaccat catatattgc attccggcgt ggcagaccgc 773821 gcctaaagca atgcctgata aagccagtga agagggctga atgctctttt ttcgggctat 773881 cattaataat agtacagcaa taatggcggc tccggcaaat gcggagaacg gaagcacgta 773941 taccggcgac tcaggaaaga tgagaatcac agccatcgcc gcaagtccgg agccttttga 774001 aatgccgaca acgtccgggg aagcgagcgg atttcggatc acaccctgta aaatcgctcc 774061 ggcagcggca agtccagcac ctgccaaaat cgctaatata atgcggggaa ggcgatattg 774121 ctggatgata aattcaaagg aatgatccag tcccagcaga ttcgtcacta ccgcatcagg 774181 tgaaatgtat aatgcaccga ttccaatgct gatgacggac agaacgatta aaatcacggc 774241 caatatgagt atcgccagta aggggcgttt ttgttttctg gttgttttct tcatttcagg 774301 tttcgccctt tccttgccaa atataagaaa aacggcgttc cgataatcgc ggtgacaatg 774361 ccgaccggtg attcataagg aaatgcaatc catctggcca gaacatctgc gtacaccagc 774421 aaaatggcac cgaacagtgc cgaaaacgga agcacgtatt gataatgttc tccgatcagc 774481 ttgcggacaa tatgcgggac gagcagcccg acaaagccaa tcggcccggc gacggctacg 774541 gaagcgccgg aaagaattaa aataatcaaa ctgatcagaa tcctgatgcc gttcatattt 774601 tgtccaagcc cttttgctgt ttcgtctccg agaccgagaa cagaaacaga accggaaaat 774661 acgagggcaa gcccgatgcc aatgacagaa aaaggagcga tggttatgac gtcctgccag 774721 ttgctgccgt cgattgcgcc tgtcatccag tacagaacat cctcacctga ctcatttaaa 774781 ataatgatgg cctgtgtcat agaggagagg aacaagtgca cggccattcc tgacagcgcc 774841 agcttgacag gcgtcattcc gccggatgag gcaatcatat acacaatcgc gccgcctgct 774901 gccgcacccg caaaagcgaa tataacagat gaatagggcg atgccggcag aatgacgaga 774961 gaagcaacaa caaaaagcga tgcacccgca ttcacaccga aaatttgggg tgaagccaga 775021 ggatttctgg tcatagcctg catcagcgcc cctgctacag ctaggctggc gccgacaaaa 775081 acgccgatta atgtgcgggg aaggcgaaga gtagagatga tgagctgttc ctttgaaccg 775141 tcccatacaa aaagatattt caatgaatct atgatgctga tgtctgaggc tcctactgaa 775201 agattcagcc caagcccaaa tataaaaata atcagtgcaa tgataaacat catcagtctt 775261 gatgatgagc gccgtttggc tgaatgatac aacagtctca cttccttact gcgtctggtt 775321 gcaaaaacga agaagcaagg attcccctcg cttctcattt gtcctattta ttatacactt 775381 ttttaagcac atctttggcg cttgtttcac tagacttgat gcctctgaat cttgtccaag 775441 tgtcacggtc cgcatcatag acttgtccat ttttcaccgc tttgagattt ttccagagcg 775501 ggttcgtttt ccactcatct acaatggttt tgccttcgtt ggctgagatg aacaaaatat 775561 caggatcgat tttgctcaat tgctcaaggc tgacctcttg ataggcgtta tctgacttca 775621 cagcgtgtgt aaagcctagc attttaaaga tttctccgtc ataggatgat gatgtatgaa 775681 gctggaagga atccgctctt gcaacgccga gaacgatgtt gcggttttca tctttcggaa 775741 gttcggcttt tagatcgttg atgacttttt tgtgctcggc aagcttttct tttccttcat 775801 cttctttatt taatgcttta gcaatggtcg taaagctgtc gatcgtttcg tcatatgtcg 775861 cttcacggct ttttaattca atcgtcgggg cgattttttt cagctgttta taaatgtttt 775921 tatggcgctc agcgtcagcg atgattaaat caggcttcaa ggaactgatg acctcaagat 775981 tgggttcgct gcgtgtgcct acagatgtgt aatcaatgga gctgccgaca agctttttaa 776041 tcatatcttt tttgttgtca tctgcgatgc ccaccggcgt aatgccgaga ttgtgaacgg 776101 catccaagaa tgaaagctca agcacaacca cccgcttagg tgtgccgctt actgtcgttt 776161 ttccttcttc gtcatggatc actctggaat ccttagactc gcttttgccg cttccgttgt 776221 tattctggct tgatgaacag ccggatacaa tgaggcaggc gagcaataaa acactcatga 776281 tggcaatcaa cttgttagaa taggtgcgca tgtcattctt ccttttttca gatttagtaa 776341 tgagaatcat tatcacatgt aacactataa tagcatggct tatcatgtca atattttttt 776401 agtaaagaaa gctgcgtttt tactgctttc tcatgaaagc atcatcagac acaaataagt 776461 ggtatgcagc gttaccgtgt cttcgagaca aaaacgcatg ggcgttggct ttagaggttt 776521 cgaacatatc agcagtgaca taaggaagga gagtgctgag ataaccggac aatttctttt 776581 ctatttcatc tgttagtgca aattcaatgt cgccgatatt catgataatc gagaaaacaa 776641 agtcgatatc gatatgaaaa tgttcctcgg caaaaaccgc aagctcgtga attcctggtg 776701 aacatccggc acgcttatgg aaaatctgtt tgactaaatc actcacaatc caagcattgt 776761 attgctgttc tggtgaaaag tattgcatta gacatacctc ctgctcgtac ggataaaggc 776821 agcgtttcat ggtcgtgtgc tccgtgcagc ggcttctcct taattttgat ttttctgaaa 776881 ataggtcccg ttcctatcac tttaccatgg acggaaaaca aatagctact accattcctc 776941 ctgtttttct cttcaatgtt ctggaatctg tttcaggtac agacgatcgg gtatgaaaga 777001 aatatagaaa acatgaagga ggaatatcga catgaaacca gttgtaaaag agtatacaaa 777061 tgacgaacag ctcatgaaag atgtagagga attgcagaaa atgggtgttg cgaaagagga 777121 tgtatacgtc ttagctcacg acgatgacag aacggaacgc ctggctgaca acacgaacgc 777181 caacacgatc ggagccaaag aaacaggttt caagcacgcg gtgggaaata tcttcaataa 777241 aaaaggagac gagctccgca ataaaattca cgaaatcggt ttttctgaag atgaagccgc 777301 tcaatttgaa aaacgcttag atgaaggaaa agtgcttctc tttgtgacag ataacgaaaa 777361 agtgaaagct tgggcataaa gcaaggaaaa aaccaaaagg ccaatgtcgg ccttttggtt 777421 tttttgcggt ctttgcggtg ggattttgca gaatgccgca ataggatagc ggaacatttt 777481 cggttctgaa tgtccctcaa tttgctatta tatttttgtg ataaattgga ataaaatctc 777541 acaaaataga aaatgggggt acatagtgga tgaaaaaagt gatgttagct acggctttgt 777601 ttttaggatt gactccagct ggcgcgaacg cagctgattt aggccaccag acgttgggat 777661 ccaatgatgg ctggggcgcg tactcgaccg gcacgacagg cggatcaaaa gcatcctcct 777721 caaatgtgta taccgtcagc aacagaaacc agcttgtctc ggcattaggg aaggaaacga 777781 acacaacgcc aaaaatcatt tatatcaagg gaacgattga catgaacgtg gatgacaatc 777841 tgaagccgct tggcctaaat gactataaag atccggagta tgatttggac aaatatttga 777901 aagcctatga tcctagcaca tggggcaaaa aagagccgtc gggaacacaa gaagaagcga 777961 gagcacgctc tcagaaaaac caaaaagcac gggtcatggt ggatatccct gcaaacacga 778021 cgatcgtcgg ttcagggact aacgctaaag tcgtgggagg aaacttccaa atcaagagtg 778081 ataacgtcat tattcgcaac attgaattcc aggatgccta tgactatttt ccgcaatggg 778141 atccgactga cggaagctca gggaactgga actcacaata cgacaacatc acgataaacg 778201 gcggcacaca catctggatt gatcactgta catttaatga cggttcgcgt ccggacagca 778261 catcaccgaa atattatgga agaaaatatc agcaccatga cggccaaacg gatgcttcca 778321 acggtgctaa ctatatcacg atgtcctaca actattatca cgatcatgat aaaagctcca 778381 ttttcggatc aagtgacagc aaaacctccg atgacggcaa attaaaaatt acgctgcatc 778441 ataaccgcta taaaaatatt gtccagcgcg cgccgagagt ccgcttcggg caagtgcacg 778501 tatacaacaa ctattatgaa ggaagcacaa gctcttcaag ttatcctttt agctatgcat 778561 ggggaatcgg aaagtcatct aaaatctatg cccaaaacaa tgtcattgac gtaccgggac 778621 tgtcagctgc taaaacgatc agcgtattca gcgggggaac ggctttatat gactccggca 778681 cgttgctgaa cggcacacag atcaacgcat cggctgcaaa cgggctgagc tcttctgtcg 778741 gctggacgcc gtctctgcat ggatcgattg atgcttctgc taatgtgaaa tcaaatgtta 778801 taaatcaagc gggtgcgggt aaattaaatt aagaaagtga aaaacacaaa gggtgctaac 778861 ctttgtgttt tttaattaat taaaatgttt attaacttag ttaaggagta gaatggaaaa 778921 ggggatcgga aaacaagtat ataggaggag acctatttat ggcttcagaa aaagacgcag 778981 gaaaacagtc agcagtaaag cttgttccat tgcttattac tgtcgctgtg ggactaatca 779041 tctggtttat tcccgctccg tccggacttg aacctaaagc ttggcatttg tttgcgattt 779101 ttgtcgcaac aattatcggc tttatctcca agcccttgcc aatgggtgca attgcaattt 779161 ttgcattggc ggttactgca ctaactggaa cactatcaat tgaggataca ttaagcggat 779221 tcgggaataa gaccatttgg cttatcgtta tcgcattctt tatttcccgg ggatttatca 779281 aaaccggtct cggtgcgaga atttcgtatg tattcgttca gaaattcgga aaaaaaaccc 779341 ttggactttc ttattcactg ctattcagtg atttaatact ttcacctgct attccaagta 779401 atacggcgcg tgcaggaggc attatatttc ctattatcag atcattatcc gaaacattcg 779461 gatcaagccc ggcaaatgga acagagagaa aaatcggtgc attcttatta aaaaccggtt 779521 ttcaggggaa tctgatcaca tctgctatgt tcctgacagc gatggcggcg aacccgctga 779581 ttgccaagct ggcccatgat gtcgcagggg tggacttaac atggacaagc tgggcaattg 779641 ccgcgattgt accgggactt gtaagcttaa tcatcacgcc gcttgtgatt tacaaactgt 779701 atccgccgga aatcaaagaa acaccggatg cggcgaaaat cgcaacagaa aaactgaaag 779761 aaatgggacc gttcaaaaaa tcggagcttt ccatggttat cgtgtttctt ttggtgcttg 779821 tgctgtggat ttttggcggc agcttcaaca tcgacgctac cacaaccgca ttgatcggtt 779881 tggccgttct cttattatca caagttctga cttgggatga tatcaagaaa gaacagggcg 779941 cttgggatac gctcacttgg tttgcggcgc ttgtcatgct cgccaacttc ttgaatgaat 780001 taggcatggt gtcttggttc agtaatgcca tgaaatcatc cgtatcaggg ttctcttgga 780061 ttgtggcatt catcatttta attgttgtgt attattactc tcactatttc tttgcaagtg 780121 cgacagccca catcagtgcg atgtattcag catttttggc tgtcgtcgtg gcagcgggcg 780181 caccgccgct tttagcagcg ctgagcctcg cgttcatcag caacctgttc gggtcaacga 780241 ctcactacgg ttctggagcg gctccggtct tcttcggagc aggctacatc ccgcaaggca 780301 aatggtggtc catcggattt atcctgtcga ttgttcatat catcgtatgg cttgtgatcg 780361 gcggattatg gtggaaagta ctaggaatat ggtagaaaga aaaaggcaga cgcggtctgc 780421 ctttttttat tttcactcct tcgtaagaaa atggattttg aaaaatgaga aaattccctg 780481 tgaaaaatgg tatgatctag gtagaaagga cggctggtgc tgtggtgaaa aagcggttcc 780541 atttttccct gcaaacaaaa ataatggggc tgattgcggc tctgctggtc tttgtcattg 780601 gtgtgctgac cattacgtta gccgttcagc atacacaggg agaacggaga caggcagagc 780661 agctggcggt tcaaacggcg agaaccattt cctatatgcc gccggttaaa gagctcattg 780721 agagaaaaga cggacatgcg gctcagacgc aagaggtcat tgaacaaatg aaagaacaga 780781 ctggtgcgtt tgccatttat gttttgaacg aaaaaggaga cattcgcagc gcctctggaa 780841 aaagcggatt aaagaaactg gagcgcagca gagaaatttt gtttggcggt tcgcatgttt 780901 ctgaaacaaa agcggatgga cgaagagtga tcagagggag cgcgccgatt ataaaagaac 780961 agaagggata cagccaagtg atcggcagcg tgtctgttga ttttctgcaa acggagacag 781021 agcaaagcat caaaaagcat ttgagaaatt tgagtgtgat tgctgtgctt gtactgctgc 781081 tcggatttat tggcgccgcc gtgctggcga aaagcatcag aaaggatacg ctcgggcttg 781141 aaccgcatga gatcgcggct ctatatcgtg agaggaacgc aatgcttttc gcgattcgag 781201 aagggattat tgccaccaat cgtgaaggcg tcgtcaccat gatgaacgta tcggcggccg 781261 agatgctgaa gctgcccgag cctgtgatcc atcttcctat agatgacgtc atgccgggag 781321 cagggctgat gtctgtgctt gaaaaaggag aaatgctgcc gaaccaggaa gtaagcgtca 781381 acgatcaagt gtttattatc aatacgaaag tgatgaatca aggcgggcag gcgtatggga 781441 ttgtcgtcag cttcagggag aaaacagagc tgaagaagct gatcgacaca ttgacagagg 781501 ttcgcaaata ttcagaggat ctcagggcgc agactcatga attttcaaat aagctttatg 781561 cgattttagg gctgcttgag cttggggagt atgatgaagc cattgatctg attaaagagg 781621 aatatgcgat acaaaatgaa cagcatgatc ttttattcca taacatccat tcgcagcagg 781681 tgcaggccat tttgttaggg aaaataagca aggcatcgga aaagaaggtc aagctggtga 781741 ttgatgagaa cagctcactc gcgcctcttc ctgcgcatat cggcttgtcc catcttatta 781801 cgattattgg caatttaatt gataacgctt tcgaagctgt agcggagcaa agcgtgaagg 781861 aagttttgtt ttttatcacg gatatgggcc atgacattgt cattgaagta tcagacacag 781921 ggcccggtgt gccgccagag aaaatagaag ctgtgtttga gagaggctat tcttcaaagg 781981 ggatgaggag aggctacggt ctggccaatg tgaaagactc agtgcgtgaa ctgggcggct 782041 ggatcgaact ggcgaatcaa aaaactggcg gggcggtatt cactgtattt ataccgaagg 782101 agaaacaaag ggggaatcca tttgattcac atcgcgattg cggaggatga ttttcgagtt 782161 gcgcaaatcc atgagagatt gattaaacag cttgatggat tcaagattat cggcaaggcg 782221 gctaacgcaa aagagacatt ggcgcttttg aaggaacaca aggctgattt gcttctgctg 782281 gatatttata tgccggacga gcttgggacc gcgttgattc ctgatatacg aagccgattt 782341 cctgaagtgg acattatgat tatcacagcg gcaacagaaa cccgtcattt gcaggaagcg 782401 ctaagggcgg gaattgccca ctatttgatc aaacccgtaa cagctgacaa gttcaggcag 782461 gtgctgcttc agtataaaga aaaaaggaag ctgctcatgt ctcagccgga ggtcagccaa 782521 tccatgatcg accatatttt tgggaacggt gtgaagacag ctttgccggc agaggatttg 782581 ccgactggca ttaattcgat tacactgcga aaaattaagg aagcgcttca gactgcgtca 782641 gaaggattga cagcggagga acttggggaa aaaatggggg cgtcacgaac aactgcccgc 782701 cgttatgccg agtaccttgt gtcaaaggaa gaagcaagag ccgagcttga atacgggatt 782761 atcggcaggc cggagagaaa atattatttg gcggcggatt agatatgaaa aaatctataa 782821 tcctattgaa tattctattg atctttatgc agggtgatat caggcaggcg gctgcgccgc 782881 gcctgccgga cgggccgata gaaattgtcg tccctgccga accttctggc ggctgggatg 782941 tcacagcgca ggcgatccaa tcagttttga ggcagaagca gatcgtgaag gatgatgttc 783001 atatcgtcta taaatccggc ggcgggggag agaaaggctg gaaatatgtc aacaaaagca 783061 gcaaacaaac catcagcatg acgtccagcc taatattgag caatgatctt ctcgggcaaa 783121 gcaaattaaa aatgtccgat tttacgccgc tcgccattct ctccaaggaa tggcagacgg 783181 ttgcattgcc aaaaggatca gcgttaacaa atggcaagga tgtgctgaat gagatcaaca 783241 tgcatcccgg caaggtgaga atcggctttg ccccggggtt tggcaatgat gatcagctct 783301 cgttcgtcag agcggcagat atgtacggca ttgacccgtt tgacattcaa ttctcacagt 783361 atgacagcag cgaacagctc attcaggcgc tgatcagaca tgagatagaa gcggcttcca 783421 tgacactttc tgaagcgaaa ccatatgaac gaaacggcga tatcacgtta gccgctgtaa 783481 cgtctgataa aagacttccc ggttttccaa atgtaccgac gtggaaggag cagggaatcc 783541 cgtttgtttt ttctcattgg agagggattt tgggcccgaa aaatatgtct gaggaagaga 783601 tttcttactg ggatcaagcg ctaaagaagg tcacctcctc acctgaatgg aagcggaaaa 783661 taaacgaaca ggactgggaa agcttttatt taaacagcag ggaaacgaaa cggtttttag 783721 aagagcaatc tgctttttat caaagcatca tgacaggaaa ttaaaatccc gacatcccgg 783781 gatttttttc atgccgaaaa ttgatcaaaa agaacaaaac ggttttaaaa aattaaaaat 783841 acaaaaaaac caaattattt acttgcggtt ggttttccca tacgatggca aaaaggcaag 783901 acaaaaaggg gagtaaggga gaaaaaaatg taagcggatt catttaaggg ggaatggatg 783961 tgttagcaat cttaggcttt ctcatgatgc ttgtgtttat ggcattgatc atgacaaaac 784021 ggctttctgt tttaacagca ttagttttga cgccgattgt gtttgcgctt atcgccggat 784081 ttggatttac tgaagttggg gacatgatga tttcggggat tcagcaagtc gcgccgactg 784141 cggtcatgat tatgtttgcg atcttatatt ttggaattat gattgataca ggcctgtttg 784201 atccaatggt tggcaaaatt ttaagcatgg tcaaaggaga ccctttaaaa attgttgtcg 784261 ggacagcggt tcttacaatg ctcgtcgcct tggacggaga tggctcgaca acgtacatga 784321 ttacgacaag cgccatgctt ccgctctatt tgctgctagg catccggcca attatcttgg 784381 caggaatcgc gggagtcggc atgggaatca tgaacacgat tccatgggga ggtgcgacgc 784441 cgagggcggc gagtgcgctg ggggttgatc cagctgagct tacagggccg atgattcctg 784501 tcattgcaag cgggatgctt tgtatggtgg cagttgcgta tgtgcttgga aaagcggaac 784561 gaaagcgcct tggtgtgatt gaactgaaac agccagccaa tgccaatgaa ccggctgctg 784621 cggttgaaga tgagtggaag cggccgaagc tttggtggtt caatttattg ttaacgcttt 784681 ctttaatagg atgtttagta tcgggtaaag tcagtttaac cgtactgttt gtcattgcgt 784741 tttgtattgc gctgattgtg aattatccca atctcgagca tcagagacag cgcatcgcgg 784801 cgcattccag caacgtgctg gctatcggtt caatgatttt tgctgcgggg gtgttcacgg 784861 ggattttgac aggcacgaaa atggttgatg aaatggcgat ctcgctcgtg tccatgatac 784921 cggaacaaat gggcggattg atcccggcga ttgttgcctt aacaagcggc attttcacat 784981 ttttgatgcc gaatgacgcg tatttctacg gggtgctgcc gattttatca gaaacagctg 785041 tcgcatacgg tgtggataaa gtggaaattg ccagagcctc tattatcggc cagccgattc 785101 atatgctgag tccgcttgtg ccatccactc atttgcttgt cggactcgtc ggagtttcta 785161 ttgatgacca tcaaaaattc gcattgaaat gggcggttct cgcagtgatc gtcatgacgg 785221 ctatcgctct attgatcggt gcgatctcta tttccgtatg ataattcagg cgtaatgaca 785281 cacactaacg gcatacaaca ttccggaggt gtcattatga gtgatcctta tatgccgctg 785341 acttcagtca gaagcggagc ggggttcgaa gcggcaaaag gggtgcacgg cctgactgtg 785401 caaattgcga atgtctattt tattcagctg ccttctgaac ctcactcatt tgttttaatt 785461 gatgccggca tgccccaatc agccggcgtg attgtcaatg aagccaaaca aagattcggt 785521 gaagggtttc agctgaaggc gattatcctc acacacgggc actttgacca tattggggca 785581 atcgaagaga tccttgagca ttgggatgtg cctgtttata tccattctcg ggaaatgcct 785641 tatgtaacag gtaaagagga ttatcctccg gctcgtcctg acagcaagag cgggctggtc 785701 gctaagctgt cgccgctgtt tccgcggcac tctatcgata tttcctcaca tgtccaggca 785761 ctgccggaag acggttcagt tccttttctt gacgagtgga tgtggatcgc gacaccagga 785821 cacacgccgg gccatatttc gttattccgc gatgacggcc gcgtgcttgt ggcaggtgat 785881 gctgttatta cagtggaaca ggagaaaatg gctgacgtct tgatacaaaa acaggagctt 785941 cacgggccgc cggcttattt cacgcctgac acagagacgg ccgctgagtc cattctaaag 786001 ctggccggtc ttgaaccgga agcgttattg accgggcacg gcataccgat gaccggcaaa 786061 aactttcgaa gtgacttaac tgaattggca aatcggttat cgtctatttg acacccgcac 786121 cacgcgggtg ttttttattg ttttccagga agttgcagaa aaatcatttg tcttgccgct 786181 taaaaacgat acaatgaaaa gcatgaagtg atgtgaaggg gagagtttgt tggaagaaaa 786241 agaaatactc tggaacgaag cgaaagcgtt tattgccgca tgctatcagg aattgggaaa 786301 ggaggaggaa gtgaaagacc gtctcgcgga cattaaaagt gaaattgacc tgaccggaag 786361 ctatgtacat acgaaggaag agctggagca cggagcgaaa atggcttgga gaaacagcaa 786421 ccgctgcatc ggcagattgt tctggaattc gctgaatgtt atcgacagac gagacgtccg 786481 gacgaaggag gaagtgcgtg atgccctctt tcaccatatt gaaaccgcca ccaataacgg 786541 gaaaatcaga ccgaccatta cgattttccc tccggaagag aagggtgaaa agcaagtcga 786601 gatctggaat catcagctga tccggtacgc tggatatgag tcagacggag aaagaatcgg 786661 cgacccggct tcctgttccc tgacagcagc ctgcgaagag ctcggctggc gcggagagcg 786721 aacggatttt gacctgctgc cgctcatttt tcgcatgaaa ggggacgagc agcctgtctg 786781 gtatgagctg ccgcgttcac ttgtgattga ggttccaatc acacatccgg acatcgaggc 786841 gttttctgat ttggagctga agtggtacgg cgtgcctatt atttctgata tgaagcttga 786901 ggtcgggggc attcattata atgccgcgcc atttaacggc tggtatatgg gcacggagat 786961 cggagcgaga aacctcgcag atgaaaagcg gtacgacaag ctcaaaaaag tagcgtccgt 787021 gatcggcatc gccgctgatt acaatacgga tttatggaag gatcaagcgc tagttgaatt 787081 gaataaagct gtgctgcact cgtataaaaa gcagggtgtc agcatcgttg accatcatac 787141 agcggcaagc cagtttaaac ggtttgaaga acaggaggaa gaagcgggca gaaagctgac 787201 gggggactgg acgtggctga ttccgccaat ttcacccgct gccactcata tcttccaccg 787261 ctcctatgat aactcaatcg ttaagccgaa ctatttttat caagataagc cttatgagta 787321 aacaatagaa aatcgatgat ggccttcaag gctgcgggat tcagtcacag agatgtcggt 787381 aacctttgag aaagggcttc cgttctttac agcctcaaca aacgattgca gggcgttttc 787441 cggaccctct gccaaaatct cgacacgccc gtcatcacgg tttttgaccc agccggccag 787501 ttttcgctta tcagcttcca tttgaacaaa atagcgaaag cccacacctt gaacccggcc 787561 gtctacaatg attcggtatt gaagcatgta aaaaccacct tttcttttta tgataatcaa 787621 tcattttaca acctgtaaag gggatgtgtt tgtatgaaac aagagcgcta ttcagttctt 787681 tctcttaatc tgggaaaacc gcagacgctt gaatatgacg gaaagaaaat cgaaaccggc 787741 atcatgaagc ggccggctaa atcagccgtc atgctgtatc gggagaattt tgaaggagac 787801 ggacaggcgg acctcgtcaa ccacggcgga cctgataagg ctgtctgtgt ctacccggcg 787861 gagcattatc cgttttggga agagttcctc tcaagaccgc tgtcaaatgc cgcatttgga 787921 gaaaatctga cggtcgcggg cctgactgag gagaatgttt gcatcgggga tgtgttcaga 787981 cttgatgaag ctgttgttca ggtcagccag ccgcgccagc cgtgtgtaaa gctggcgaaa 788041 aagtttggtg taaaagaaat ggtgctgaag gtccagcaaa ccggctatac agggttttat 788101 tttcgcgtgc tggaggaggg cagggtgtct cccggcgcga accttgaatt gctgtccaga 788161 ggagagaaag gcatatccgt ccagttcgcg aaccgcatca actaccatga tgcaaaaaat 788221 ctcaccgcca ttgaacggat tttaagtgag gctgcactat cggaaagctg gagagcgtcc 788281 tttatgaaaa aaaaggacag gctgctgccg gttgaataga aaaaagccgc gcatatcaac 788341 gtgcgcggct ttgccatatt taagattgtt ttttctttga ttcaagcagg ttggcaagaa 788401 aataggtttt atagctttga agctttcttc cttcatggtg cgtgatcccc tgctttttta 788461 gttctgccac ataccagcct ttactgccgt aatgcatgtc agaaaactcc tttccctatc 788521 tgatttcgaa acgattggca ttgtaacatc tataaaaaga tgctgaaaag agatgcgggg 788581 aaaactgagc ctttcgcact agatgtacga atgttcttct gaatgtatat gcggagcaaa 788641 agccgaatat gatttaatgg ccggttagtt tgatcatgac aacgccaaat gtcataatgg 788701 cgaaaacaat gccgatatat gtgagcatcc cgtttttttt cttaacgccg taaacggtca 788761 taatgatgcc ttcaatgaaa aaaatgatgc cgaaaataat aaaccacatg cagataaagg 788821 ctcctttcac agacataata gtagtgtagc atatctgaaa gagccgggct gtgacaatat 788881 caagaaagcc gggcgcatat cgcccggctc atgttttatt gtttatcaac caatttgacc 788941 agaagctgtg ccaaatgttc tttctcatct tcgtctgcaa cgctccaaag ctcttgcagc 789001 agcatttctt caccgttttg cggctcttca tgctttgcga ggtagtctcc caggatcgca 789061 gcgcttttta caagcttgcc gtcatccaat cccagctttt tgcctcggtt gacttgtttt 789121 ttcaggtagc ctttaaattc ctcaaagtct tttaaaatgt cttcttttat tgtgccatgc 789181 atcgcgttca tttcgttttc aatttggatt ttttcttgat ctctgttcat tgcaagacct 789241 cctcgtacag aataatgatg ctttacctgc aattggagga ggttaaacct gccggaagcc 789301 cggaatgtgt tttacagttt cgtcaggata atcggttcat cttttgtgat gacgatcgtg 789361 tgttcaactt gggcaaccat gcttttatcc ggcgtcttga acgtccagcc gtctccagct 789421 tcaacaatcg tttctgcttt cgttgaaata aacggttcaa gcgcgatgac tgtgccattt 789481 ttgaacagcg cattatcaaa cggatcataa tagttcatga tgtggttcgg cgcttcatgc 789541 aggcttcggc cgattccgtg gccggtcagg gttttgatga cggtaaagcc ttgagagcgt 789601 gcttcatgat aaacggctct tccgatctgg ttttggcgct tgcccgcttt tgcctgctga 789661 agcccctttt gaaaagcgtt ttccgcgcat tggcaaagct tatgaaggcg ttcttctcct 789721 tcaccgagca caaatgagat gcctgtgtcg gaatagaagc cgccaaattc agcggagatg 789781 tcgatgttga caaggtcccc tgcttttaaa attttggatg tgcttggtat gccgtgagcc 789841 acttcatcat ttacgctgat acatgtcaca cctggaaaat cgtattcctt ctcaggagct 789901 gaaacggcgc cgtgctcatc aagcacagct tttccgataa ggtcaaggtc ttttgtgctc 789961 atgccgggct ctgccttccg cttcatttct tcacgcgcaa gcgcgacgat tcttccgatt 790021 tttttcaggc cttctaattc ttgatcgttt gttacaatca tctgtcattc ccgctttctt 790081 tttaaataat ctagattaag cttaccacaa ctgtcttaaa aataggaaac acacggacct 790141 gggaaaaaag aaataccccc gggaaaattg gtatagatca ctagatatct tatatggtat 790201 atttgaaaaa aaagggtatg agggggatgg gtatgctttc atttttacaa aaactcggga 790261 agtcatttat gctcccgatt gcggttctgc ctgcggttgg aattatcctt gcgcttggca 790321 gagaggatgt atttaatatc ccgtttgtct atcaggcggg gacggcggtt tttgatcatc 790381 tgccgcttat ttttgcgatc ggtattgcca tcggcatttc aaaagacagc aatggggcag 790441 cgggtttatc aggggcgata tcgtatctga tgcttgacgc ggcaacaaag acaattgata 790501 aaacaaataa catggcggtg tttgggggaa ttattgccgg tttaattgcc ggttacacct 790561 ataaccgctt caaggatacc aagctgcctg aatatctcgg gttcttcagt ggcagacggc 790621 ttgtgccgat tttaacagcc attattacga tcattttagc gggcatattc ggagtggtct 790681 ggccgccgat tcaatcgtgt atcaactcgt ttggagagtg gatgctcggg ctcggcggca 790741 tcggggcagg catattcggc ctattcaaca ggctgttaat tccgcttggc cttcaccatg 790801 tgctgaacaa tattttctgg ttccaattcg gagaatataa cggagtgaca ggggatttgg 790861 cgcgcttttt cgcgaaagat ccgactgcgg gcacatatat gaccggattt ttcccaatca 790921 tgatgttcgg tcttccggcg gcgtgtctgg ctatggttgt gactgcgaag ccgtctaaac 790981 ggaaagcgac ggctggaatg atgattggat ttgctttaac ggcgtttatc acagggatta 791041 cggagccgat tgagtttgca tttatgtttt tatctccgct tttatacgct gttcacgcgg 791101 tcttaaccgg gttatcttta tttatcgtca actggctcgg catccgctca ggcttctctt 791161 tttcagccgg agctatcgat tatgtgctca gctatggaat cgcggaaaaa ccgctgcttc 791221 tgcttttggt aggtatatgc tatgcggcag tatactttat cgtgttttat gtactgatta 791281 aggctttgaa tttaaaaacg cctggacggg aagacgatga tgtggatgaa gtgctggatg 791341 aaaatactgt tcaggatgta aatgaaaaca tcatgctgaa agggctcggc ggaaaagaaa 791401 accttcaaac cattgatcat tgcgccacaa ggctgcgact gactgtgaag gataccgctt 791461 tggtggatga agcactgcta aagaaagcag gcgcaaaagg ggttgtcaaa tcgggcgggc 791521 aatcggttca agtcattatt ggcccgaatg tggaatttgc agctgaggaa ttgagggctg 791581 ctgtcaaata aaaaagcgga gagggcaacc tctccgcttt ttcttattta tcttcgttat 791641 cctttgacgt ttcggaagaa tcttcgtcat gttttgtgta atcataatca gaaggattca 791701 ccttcttaaa acctttcggc tcgtagaacc gcagcaggtc tccgtttatg attttatcgg 791761 acatttcaag ttccttcttg acgagtgagt cttctgactt gtcgacttcg gattcatcga 791821 gttcttttcc ggttttcgtg tcgtaatact taccggatat tttcgtgtac ttcggtgaaa 791881 taaagtctcc gtttcggaac ggaatcactt cacggtgttc tttcgataaa atatcagaac 791941 cggacatcag atagtccttc gtatccactc cgagcagatg cagaatggta ggagccacat 792001 caacgtctcc ggcatattta tgaactttct cgcccttcac gccggcagcg tggataaaga 792061 gcggcacccg ttgaagctgg gcgttgtcgt aatcagtgat ttcatccttg ccaagcactt 792121 tcgccatcgc tttattgtgg ttttcagaga tgccgtagtg gtctccgtac atcacaataa 792181 tcgatttatc atataacccg tcttttttca gatcattgaa gaattgttca atggactgat 792241 caaggtaatg ggctgactgg aaatagttat cgacgacaga gtcaccaaag tctccagccg 792301 ggaagtctgt atccccctca tccattccga atgggaagtg gttggaaagg gtaatgaact 792361 tcgtatagaa cggctgcggc aggctttcca gcagcggcat tgattctttg aagaacggtt 792421 tgtctttcat gccgtagttt ttcgtgtttt cttcgttcat gtcatagtaa gcagaatcaa 792481 agaatttatc aatgccttcc gccttgtaca tttcgttacg gttccagaac gtctgcgtgt 792541 tcccgtggaa agtagcagat gtgtaattct tagacttcag aatcgccgga acggattgca 792601 gcgtgttttg cgctttgttt acgaaaactg aaccttgagc cagcgggtac agagagtttt 792661 ccatcataaa ttcagcatca gatgttttac cttgtcccgt ttggtggaaa aagttatcaa 792721 agtagaacgt ttcgttatca tgtgccagtt tatttaagaa tggtgtcact tctttgccgt 792781 caattttata gtcgatgata aatgactgca aagattcaag tgaaacgtaa atgacgtttt 792841 ttccttccgc tttgccgaaa tacacgttat tcggcacatc gtaattggct ttcatgtagt 792901 tttctacttc cgttacgtcg ctggaatcgg caagcgcgcg ctggctgttg gacttgatat 792961 tctgtacagc gtcataaatc gtgaaattgt atgttcccaa gtatttcaca agatagttcc 793021 ggtcgaatga tcttgtcagc aattcaggac ggtctgattc cgcaactgcc aggttgatca 793081 agaacacaag aattgaagac gcaaaaataa ttcggaacga ttttttgctt gacgtttcgg 793141 caggcttgtt tactttgatc gccaagatga tcaggatgat cgtatcgata aagtaaaagg 793201 cgtcagtcgg tctcatcagc gaaaatgcgc tgtcaccgag ttggccgccg tttgttttag 793261 cctgcataat gaccggaatt gtaataaaat cattgaaaaa tctgtagtac acaatgttgg 793321 cgtacagtaa aaaagacatt aaaaaatgaa tcactataat ggctgtctgc tgtaattttt 793381 tcttgaacaa gagtccaaag ccaagaaaga acaagcttga gctaagagga ttcacaaaaa 793441 gcaatatttt ttgtatcgtg ttgtctattc ctaagttgaa attcaggaca taaccgacat 793501 acgttttgat ccataacagg acgaccgcaa ttaagaagaa ggccagtcct ctttctttta 793561 taaatgtttt cattgttaca ctcctttttt ccgatccagt tcgagcgaaa cgatagaaaa 793621 aacgaacgta tccaatataa cacgaatcag cagattagaa aagtgaaaat cgtatgaggg 793681 agaaagtggc gaaaaacgcc gtcgaatcaa cgtttcgctt tgatattacc aaatgtaaaa 793741 caaggtatct ttctagaaat aaaggaataa aatggtacat tgagaattgt atgataaaat 793801 ataaggtata gataaaaaga ggtgaaatga tggatttttc ccatattgtg tctgaagata 793861 aaattaagcg cgccatcaaa gacggggact ttcaaaacct cccgggaatg gggaagccgc 793921 tgccgaagga tgacgcggca cacttgccgg aatcgctgcg catgggctat cgtattttga 793981 aaaacgcggg aatggcagag gacgagggcg cgctcaaaaa agagcttatg accatcgacc 794041 atttaatcga aaagtgctat gacgaaaaag aacgcgagca attaatcaga aaaaaatctg 794101 aaaagcaatt gctgcttgat aagcttgtcg acaaaaaagg catgttttca aagccagcat 794161 ccgcttttta taagaataaa gtatatgacc ggcttggacg aaacagacct tcttccagct 794221 gatttgtctt gtctgcagga tggcgattga taaaagccat cctttttatg ttccaagttc 794281 tatgtcaaaa ggtttatgtt tttccatcta tgggaaatga ttcataaacg aaaaaagggt 794341 gatgggatgg aacgactatt agtatggata gagcatatat ctgattggct gtggggtccg 794401 ccgctaatca tcctgctgac ggggacgggc ttgtatttca ctattttgct gaaaggtttt 794461 caatttcgct atcctttata cattttcaaa cagacaatcg gcagtgtagg aaaaaagccg 794521 aagggagaag gcacagtcac accgcttcag gcattgacct cagccctcag ttcaacgatc 794581 ggtgcagcga acattgtcgg tgtgcccgcc gctattatgt ttgggggacc aggagcggtt 794641 ttttggatgt ggcttattgc cttatttgcc atggcgatta agttttctga aagtgttctt 794701 gctgttcatt acagagaaaa aaatgagcag ggtgaatacg tcgggggacc gatgtattac 794761 ataacaaaag ggctgcgcat gaaatggctc ggcgtattct tctctgttgc gctgattgtg 794821 gagctgattc ccagcattat ggttcaggga aattcggttt cagtctcgct tgccgagacg 794881 ttttctttca ataaaatata cgcaggaatc ggaattgcat ttttgattgg gttagtggtg 794941 ataggagggg taaagcggat cggaaaagta acagagtttg tcgtgcctct tatggcaggg 795001 gcatacgcag gtgccggtct cctgattgtt ctcatgaatc tatcatcagt gccggcgttt 795061 ttctctctcg ttttttcaaa tgcgtttacc tcttcttcag cagttggagg gttcgcaggt 795121 gctgcgttgg cggaaaccgt tcgctgggga tttgcccgcg ggctgtattc taatgaagcc 795181 gggatgggaa cagccccgat tgcacatgcg gcagcaatga ctgatcatcc tgtgcggcaa 795241 gggttttggt ctgtgatcgg cattgtcatt gacaccttaa tcatctgtac gactaccgct 795301 tttatcgtcc ttgcatccgg tgtatggaca gggaagaacg cctcaaatga cccggcagca 795361 ctgacaacgg ccgcatttca gcactatttc ggttctggag gaggatactt cgtttcggtt 795421 tccctggtct tctttgtcgt atcaaccatt atggttgtca ttttttacgg cgtaaagcaa 795481 gctgaatttc tgttcgggcg gctggcagga catgtgatta aattcgttta tttagcggct 795541 attatcatag gtgccgcagg cggagcaaaa gccatttggg gcgtattgga cttagcattg 795601 gtttttattg ttgtcccgaa tgtgattgcg ctcttgttat tgagcagaaa ggtaaaagcg 795661 ctgtacaccg aattctttac atctgaacag tactacctga aagatataag aaaaacgaaa 795721 caaaagcctg tttatccaac aaaagaagct aaaaattcct agtgttttgc ttttgcgccg 795781 aacaatgctt tgctttttat gatcaaataa atgagtaaag gcagcaaaag agaaatcact 795841 acattaatga ttggtttgat tctgttaaag tcgattagct gatttgtatt taaaaaaaac 795901 caaaagccgc atacgactga gaacatgccg gttggtgtat acatggcttt cgggtcgatt 795961 tttgagtgta aaaacgaaag gccgtatacc acgatatata gggaacctgc tatcttcacc 796021 ataatgaccg gaatccaaaa agccgcgatg atcaggtctg agcgatccag aaaatccgta 796081 atgcggatct gcctgatgac catataagca ggatcaaaga aagtagatgt caggttggga 796141 ccaaagacag aaattgaaga aaataacatc acggccagca ataaagcgcc cagcagtatc 796201 gcgaaaatgg tgtattttag cgggacgctc cggtttgaga agagaagcgg aaggataatc 796261 aattccccca ttgtcccaaa cgcgtaatag cctgattgaa ggtatgggat tagaccttca 796321 aaaacaggtg tcaagttttg aagctcaatt tgtgtggcca gcgtaaatgg aaggaacaag 796381 accaggatgc cgaatggaaa taggaatatc tgcgccattc tggtcaatgt ttcttttccc 796441 tctctggcaa tacagatcgc cacaaagata ataacaccgc caagaacagc cattggtgtt 796501 ctcgggagaa ataaaatgtt aatcaaattg atgaaaaaac gtatatcatg agcattgatt 796561 aacaggaaat acaaagaaaa cagtaaaatg ataatccggc ctgcgattgg tgaggaatcg 796621 ctcagcagct catagatatt tttatcctga tgctttttca tcagcctatg catgagccag 796681 agtgccggaa tcacgatgac aacgccgagg atgtagctgt gccaggcatt ttgttttgct 796741 gattcgatca tgagaatcgg agcatgcttt aatccgactg ctaacgtata cagagctccg 796801 aaaaataatc cttggtatgc agaggtcttg tccataaagc acatcctttc tgtcatgttc 796861 aaaacggaat atatttaaac aggtgcccca gccgcggaag caggggattc actctcatat 796921 aaatccatag aaaagcactt cctgcaatta gcaggctgaa ggcccatttt gttagattgt 796981 tagcggaacg aaaattcttc cattcatatg cgtatatggc aatgcacaca atcaatgtct 797041 gtacgatata gctgatcatg ctgacgcacc tccattaatg gctgatcgtt ttgtatagga 797101 caccgccctg ctcaatcgtc acaattggga cgacgtgaac ctccatatcc ttatatacct 797161 cttcccattc ctttttcagc agattcttcg tggttgccgt gcttctgatg gtcctgtctt 797221 gaaagccggc cgggtccgcc tttagctttt gcaaacgatg aacggtgctg atcacgtcct 797281 tctttatggt tctgtttaat gctttttgaa tgatgtaata ctggtcattt tctctcgtct 797341 cataggttga ttggttttcc ataataattc ctttggctct gatctcgatt gtcattgaca 797401 gctttccgtt tttttcagcg gcatgaaagg atgcattgga cttttgaagc tgaatggatg 797461 cttgccccat ttgattcggc aggtctacta tgaattctgg ctggcgggct tgattcagca 797521 acatcagggc tgctgtcatg tgttcatctt tgaaaatatc catcaatctg tcctttttaa 797581 agatcgcaag cccgtcaatt ttcaaattag atttgccttt ccctccaggt tttgttttag 797641 atgcagagat gaccggtgca tacggatcac tgcctatttc tactagatca gacatgaatc 797701 tgcttaagaa aacggggcgg ctcgttgcga taatggccag ctcccgaatc atttccgccg 797761 gaaactgttc aagctgaaca tcggtattta aaatgtcccg cgcttctccc cggctgacta 797821 aaatgagcgc cgttaatctg ttctgcggat ttcgcgttaa aatatcaaag actggggcaa 797881 cgccgtctct cgccatatcc tctccaataa tgactgtacg tctgtgggac gtattgattg 797941 tccgtgacaa ggaggtttgc agcttgttgt tcgcttctct gatcgtagtg ccggaagctg 798001 aatcaacata ccatgttttt gaaccggcag ttccgccgcc gccccctgtt tgtccgccta 798061 attggccgac caagggaatc tgcatggcca ctcgatactg atcttttttc ttatcaatgg 798121 ctgagctgac aacaaatgca atgtcattga tttctgtccg gtcccagcac cccgttagaa 798181 ggatacaaat gagaagcggc aaaacacact tatatattgt tttcttcatc ttttgggtcc 798241 tctcttttcg ctcccttctg tccgttgccg cgcgaatacg tgcccggcct tctggtcatc 798301 gtccaccaag gcgccctgac aaaaatatct tttacttcat ctcgtttaaa cggagaaatc 798361 ccggataaat aaggaatgcc gaaagattgc agcttgcata aatgaagcac taagataatc 798421 gtgccgagca taatgccgaa tatcccaaaa atactcgcca aaaacataag cgggaaacga 798481 agcatcctga tggagatagc taagttaaac cgcggaattg taaatgacgc gatccctgtt 798541 aacgatacga tgatcaccat gggggcagac acaattcccg cttcaacagc ggctgtccca 798601 atgactaggg ccccgagaat actgacggtc tggccgatgg ttttcggcag gcgcactccc 798661 gcctcacgga gagcctcaaa agaaatttcc ataatcaatg cttctatgat ggcggggaaa 798721 ggaatcggtt cacgcgcaga ggccacactg aacattaagt ttgtcggcat taagtcctgg 798781 tggtatgtaa taacggcaac ataaatagcc ggcaaatata aagcaacgaa taaaaacata 798841 tagcgaagcc agcggattaa gttagacatc aaataacgct catagtaatc ttcactggcc 798901 tgcataagct gccaaaacgt aatcgggcct gttaagacaa agggcgtatt atctgtgaaa 798961 atggcaaatc ggccttcgag aagctgggcg gcgacggtgt ccggcctttc tgtgtattgc 799021 agctggggga atggcgagta cgtgtcgtct tcgataaatt cttcaatata tccgctttct 799081 aagacagcat caatctttat ctttttgatt cttttttttg ctttgtcaat aacctttgga 799141 tcggcaagcc cgtcaatata ggccaagaca acatcggttt tggttttcgt gccgatttta 799201 aaagagatca ttttaagctg aaacgttttg acgcgaaagc gcacaagagc ggtattgacc 799261 ctgaggcttt cagtgaagcc ctctcttgac cctctgatgg tcgattctgt tatcggctct 799321 tcaatgcttc ttctttgtcc gccttttata tttaagatca ggccttttga gtgcccgtcg 799381 gcaaataaaa ccgcgttccc ctcaatgatg gatgcagcca ctttgctcat actcgtttct 799441 aatgcaacac ttgaaattga tagagtattt tgcagcgcct cttcatgttc atctatttga 799501 tccgtcaaat gcattaagaa agggcggagg gcgtgatcct gaatatgttc agattttaca 799561 attccttcga tataaacaat aaatccgcac agcccgtttc caaagtcaaa ttgtctaaat 799621 acgatgtctg agcagccttc tgttaataag gtcagatttt cgaggttttc cttcaaattg 799681 ggagagatcg gtctgtcctg attgtcttca agctctttga tgagctgaag cgctttgtcg 799741 cgtttattca tagaggctca ccctgctttt taatgtcata ttcaataagt gcttgtgact 799801 tttagggtaa ccttgtctgt ttcatatatt ccagactagg atgaaagcgc tataaaaaag 799861 tgttgactac ctgtatatac aggaatacaa tatgattata agttgtatat acaagttata 799921 aaaacggata cggaggggtt ggcatggggg aactgaacaa atcggcacgt cagattgtcg 799981 aagcagtcgg cggtgctgaa aatattgcag cggcaactca ttgtgttaca cgtttgcgtt 800041 ttgctttaat agatgaaagc aaggttgacc aagagatgct tgatcaaatt gatgtggtaa 800101 agggatcatt ctcgacaaac ggacagtttc aggtcgtaat cggccaggga actgtcaata 800161 aagtatatgc tgaactggtt aaggaaacgg ggattggcga gtcaacaaag gatgaagtga 800221 agaaggcctc agaaaaaaat atgaatcctt tgcagcgtgc tgtgaaaacg cttgcagata 800281 tttttattcc aatattgcct gcgattgtca cggcgggtct tttaatgggg atcaataaca 800341 ttttaacggc ggaaggcatt ttcttcagca caaaatcgat tgtgcaggtt tatccgcagt 800401 gggcggatct tgctaatatg attaacctga ttgcaggcac ggcctttacg tttttgcctg 800461 cgttaatcgg atggtctgcc gtcaagcggt tcggcggcaa tccgcttctc ggcattgtgc 800521 tcggggttat gctcgtgcat cctgatttgc tgaatgcgtg gggatatggc gcggcagaac 800581 aaagcggaga gatcccggta tggaatctat tcggcctaga ggtgcagaaa gtcggctatc 800641 agggccaggt gctcccaatt ttgcttgctt cttatatgct ggcgaagatt gaggtatttt 800701 taacaaaacg cacacctgag ggcatacagc tgctcgttgt cgcaccaatt acgcttctct 800761 taacaggatt tgcctctttt atcattatcg gcccgattac atttgcgatc ggtaatgtac 800821 tgacttcagg gcttatctcg gtgtttggtt cttttgccgc actgggcggt ctgttatatg 800881 gcggtttcta ctcagcgctc gtgattaccg gtatgcatca cacgtttctt gcagtcgacc 800941 tgcagctcat cggttcaaag ctcggcggca cctttttatg gccgatgctg gcgctttcta 801001 atatcgcaca aggttcggcg gctctggcca tgatgtttat cgtgaaggat gagaaacaaa 801061 aaggcctctc cctcacatca gggatttctg cttatcttgg cattacagag cctgccatct 801121 ttggggtgaa tctgcgatac agattcccgt ttatcattgc aatggtcagc tctggcctgg 801181 ccggaatgta tatttcttct caaggtgtgc tggcaagctc cgtcggtgtc ggcggcgtgc 801241 cggggatttt ctcaatcatg agccagtact ggggcgcgtt tgcaatcggg atggctattg 801301 tattgatcgt gccgtttgcc ggaacatacg cgtatgcgag attcaaacat aaataacaag 801361 tggggagcgg gacgtgttga acgttccctt ttcccgtttt caatttaaat atggtggtgg 801421 aaacagatga aaacagaaca aacgccatgg tggaaaaaag ctgtggttta tcaaatttat 801481 ccgaaaagct ttaacgatac gacaggaaat ggtgttggcg atctgaacgg cattattgaa 801541 aagctggatt acttaaaaac gctacaggtg gatgtgcttt ggctgacgcc gatttatgat 801601 tctccccagc atgataatgg gtacgatatt cgtgattatt actcgattta tcctgaatac 801661 ggaacgatgg aggattttga gcggctagtg tccgaagcac ataaaagaga cctgaaagtc 801721 gtcatggatc ttgttgtcaa tcatacgtca acagagcaca aatggtttcg cgaggcgatc 801781 tcttcaatag acagcccgta ccgtgatttt tatatatgga aaaaaccgca ggaaaacggt 801841 tctgttccga cgaactggga atcgaaattc ggcggctcgg catgggagct tgacgaagca 801901 tcgggccaat actatttgca tctgtttgat gtgacgcagg ctgatttgaa ttgggaaaat 801961 gaagaggtca gaaagcatgt ctatgacatg atgcattttt ggtttgaaaa gggaatagac 802021 ggctttaggc ttgatgtcat caacctgatt tctaaagatc agcgctttcc gaatgcggag 802081 gaaggcgacg gccgctcttt ttacactgac gggccgcggg tgcacgaatt tctgcatgaa 802141 atgaacgaaa aggtgttttc acattacgac agcatgacgg tcggtgagat gtcttcaaca 802201 accgtagacc actgcatccg gtatacgaat cctgacaata aagaacttga tatgacattc 802261 agcttccatc atctcaaggt tgactatcct aacggcgaaa aatgggcctt ggcgccgttt 802321 gattttttga agctgaagga gatcctatct gactggcaaa cggggatgca cgcaggaggg 802381 ggatggaacg ctctgttctg gtgcaatcat gatcagccgc gcgtcgtatc aagatatgga 802441 gatgatggcg catatagggt gaaatcggcg aaaatgcttg ctacggccat tcatatgatg 802501 cagggcacgc cttatattta tcagggcgag gagctgggga tgacgaatcc gaagttcact 802561 gacataagct cctatcggga tgtcgaatcg ctgaacatgt atcacgcctt taaggaaaaa 802621 ggaatggctg atcaagatat tacagccatt ttacaggcga aatcccgtga caattccaga 802681 acccccgttc agtgggatgc tacggaaaat ggtggtttta caacgggcac accatggata 802741 ccggttgcag gaaattaccg ggaaatcaat gctgaagcgg cgctgaggga tcagaattcg 802801 gtgttttacc attatcaaaa attgattcag attcgcaaaa tgtatgacat tgtgacagag 802861 ggtacgtatg agataattgc aaaggatgac ccgaacattt ttgcgtatct cagacacggc 802921 agcaatgaaa agctgctcgt gatcaataat ttttacggga cagaggcggc ctttacactg 802981 ccggactctt tagcgcctga cgaatggaag gcagaggtgc tgttgacgaa cgatgaagca 803041 agggaagggc ttcagaacat gacgcttcgc ccatatgagt ccattgttta tcgtttaacg 803101 aaaccgtgtt aaactaagct gggtggtcca taatgaaggt gaataaattc atcacaattt 803161 ataaagacat cgcacagcaa attgaaggcg gccgatggaa agcggaggag attcttccgt 803221 ctgaacatga gttgaccgca cagtacggta catcaagaga aacggtccga aaggcgcttc 803281 atatgctcgc gcaaaacggt tatatccaga aaatcagggg aaaaggctcc gtcgtgctca 803341 atcgtgaaaa aatgcagttt cccgtttcgg gccttgtcag cttcaaggag ctcgcgcaaa 803401 cgcttggcaa agaaacgaaa acaactgtac acaaattcgg gctggagcct ccgtcagagc 803461 tgatccaaaa acagctccgg gccaatctgg atgacgacat ctgggaagtc atcaggtcta 803521 gaaagattga cggggaacat gtgattttgg acaaggatta ctttttcaga aagcatgtcc 803581 ctcacctgac gaaagaaatt tgtgaaaact ccatatatga atatatagaa ggagagctcg 803641 gtctttcgat cagttacgcc caaaaagaaa ttgtagccga gccgtgtacg gacgaggaca 803701 gagagctgct cgatttacgc ggctatgacc atatggtcgt ggtgagaaac tacgtctttt 803761 tggaggatac cagtttgttt caatatacgg aaagcagaca ccgtctcgac aaattccgat 803821 ttgttgattt tgcgcggcgg gggaaatgag agaggcgcct gcctgcggca gcgcgctttt 803881 ttgtttggta tcaaaattga tactatccaa caaaaatgtg cgtactttta ctttttatca 803941 taatggctac aatagagatg agagtaatct aaaggagagg tgttttacat ggcagatcta 804001 aagacacaaa ttctggatgc atacaatttc aggcatgcga ctaaggaatt tgacccgaat 804061 aaaaaagtgt cagacagcga ttttgaattt attttagaaa caggaagact gtctccgagc 804121 tcactcggcc ttgagccttg gaaatttgtc gtcgtccaaa atccggaatt ccgcgagaag 804181 cttcgtgaat acacatgggg cgcgcaaaag cagctgccga ccgcaagcca tttcgtcctg 804241 attcttgcgc gtacagcgaa ggatatcaaa tataatgcgg actacatcaa acgtcattta 804301 aaagaagtaa aacaaatgcc tcaagacgtg tacgaaggct atttaagcaa aacagaagaa 804361 ttccagaaaa acgatttgca tttgcttgaa agtgacagaa cattgtttga ctgggcatca 804421 aaacaaacct atatcgcgct tggcaacatg atgactgccg ctgcgcaaat cggtgttgat 804481 tcctgcccga tcgaaggctt ccagtacgat cacattcacc gtattcttga agaagaaggc 804541 cttctggaaa acggaagctt cgatatttct gtgatggtgg cattcggcta ccgagtgaga 804601 gaccctcgtc cgaaaacaag atctgctgtt gaagatgttg tgaagtgggt ttaaaagaag 804661 aaagctgctc gcatagcgag cagctctttt ttatgcctga ttcgctctat tctgttttct 804721 cctctgatgt aagtacattg ccgttccgag tgcgctgatc agaaatccgg ccaacaggat 804781 cgagtacatg gatgtggctg tgtccggaag caggccgcca gccggaccgt ctgttcctga 804841 tccgcccgaa ccgtttccac cagagccgtt agtcggttga gtgccgggag gcgtatcatt 804901 tcctccgttt ccgtcagttg gctgttttcc gcctggtttg tcggagcctc cgccatgatt 804961 gccgtcatca ccgcctgtcg gttgatctga cgggaatgcc ggcggtttgt tgtttgaacc 805021 ggaatttaag atcgtgtatt cgctgaagtg gtttgtatat cctgtcacca tatcatcatc 805081 gactgatccg tgacctgtct ttgtgaaagc tttctttttt ctatcgacgt gataaatggc 805141 agggttatgg gcttcttcaa tatcaaacat gcgaagcgaa agctgtacgg gctccttgaa 805201 tgattttatt tcttttcctt tttgcttcac tgtaaagtca tatacatctg acagtgacac 805261 atccaattct cccgtagact tgattccgat tgcagtgtct gcggttttaa ggttcgccat 805321 tggcatcttc atgctgtacc agtagttgaa catcgtcaat gaaggatctg actctctttc 805381 tttcaaaagt ttgacctgat cttttttcac tttaagattg ataggcttct cttgagatcc 805441 ttcatgtatt ccataataga caaatggcgt gttggcattt ttagcataaa tcgcaaattt 805501 gtcttcatca agtgtccagc tgccgtcctt ctgctttgtc ggcaggaata cttctttgat 805561 tcgtccttca actttaggag agaccttgtt tcctagtttt ttcagctgtt cggtgaaaat 805621 ctcataatca acgtagccaa ggtcttcacc atgggaggct tctgtaaaga cagaatatcc 805681 gtctcctccg gcaccgacaa aattatttgt tgccacgcgg taggtatcat ccgtatttat 805741 agcaactttg tctccgttag gcgattcaat tttcacttct aacacacggt gtccaggttt 805801 gttgtttaat gtaaaggtat attcgattcc ggccacctga gggaaagcgc cgccgccatt 805861 ttccacattg cttaggcctt gttcaagggc ttctttaatt tgttttccgg ttaaatcggc 805921 cacgtaaagc gtattgccga acggcatcac gttgagcacc tcgccgagtg tgatatcacc 805981 tttgtcaatg cctgctctga tgccgccgcc atttgttatc gctattctgg cgccggctgc 806041 ttctttcgct tttgccagca taccgtccgc gatgaagttt ccgagattcg tttctttcgt 806101 gcgcacatgc tcacgctggc cgtcaagcgc cacatccgtg tagccgactt tttcattttt 806161 cacgtcctct aattcatttt tgaactgatc gagctcttgt tttgcttctg ggttttcttc 806221 tgtatgttca tcaattggca gcacgctcag atttgattta tctgtttgca caacgccttt 806281 ttcatcaaac gcgacatcaa cgcgccccaa gaattggccg tattcttttg cctgcgccac 806341 gatcgtcggt tcttcgttgt tcacgacctc cattttgtct acgagggtgt gagtgtgtcc 806401 gccgatgatc aaatcaatgc cttttacttt tttggctagc tcaagatccc ggttatgtcc 806461 gatgtgggtt aaagcaataa ttttatttac cttttcttct tcttgaatcg ctttgacggt 806521 gttttgtgct gtttcaaagg catcattgaa tacgatgctt ttgcccgggc ttgatgtggt 806581 ggctgtatct tctgttgtca ggccgaatac ggcgactttc tccccgtcaa cgtctaacag 806641 aatgtaaggg tgaatgccgg cctctttctt ttcacctgcc gtaaaggttt gcggcttttt 806701 gacaaatgat ttcagcttgg gctcatttga cacatctacg tttgcactga caatcggaaa 806761 ttccggcgct tcaaagtgat agcggttcgc cggatcaacg gttgcgctgt ttccgcttag 806821 aaaatcagaa agcaccgtcg ggcctttgtc aaattcatgg tttccgaagg tcatggcgtc 806881 atagcccatc atgttcatca ttttcagatc ggccaaaccg ttccatttag taaaatacag 806941 atcgccggaa aacacatctc ccgcatcaag gagaatattg tgatttgttt cgctgcgtac 807001 ttcgttgatt ttcgtcattc gtctcgctgc atcatcgaga tgggcgtgcg tatcattggt 807061 gtgcatgacg gtcagatccc acagtccgtc tttaggagga tctggatttg aatcatcatc 807121 gaattgcagc ttatacacac catagccttc attcgcagac ttgcctacat aagcgacatc 807181 gtctgcttta tcggcaaatg gcttggccaa aagcgaggat tcaaacgtca gattcgtgcc 807241 ggaaacaggc gcgattgacc agttgttgtc tgcttttgga ttgactgttt tttgttcaat 807301 aatgtaatcc atcagcacct gcctattttc aactgcagag ccgtggacaa ttttatcgct 807361 cgtcagatga gggaacccgc cgcctccgga cgcacgatag ttattggtga ctacgagaaa 807421 ttcctggctt gggctgatcg gcttgccttc ataggaaaga ttgatgatac gggatgaatc 807481 cgcattgatc acttttccgt tctcattgta tttagccggt tttgtcacat cgacctgata 807541 tgtgacaccg tcaatcacgt caaaattata ggagcggaaa ttctcgttca gcaaggcctg 807601 gtcgccgcct ttagctggat caatttgatt gaattggcct gctgacatct ccagccagtc 807661 cttgacctcg ctgcctgtca gcttgacgat ttgaacagta ttatcgtaaa gatacaagtc 807721 accgacattt ttaatcgcaa gatctccggc tggaatgttt gtatagtaat tggctccgtt 807781 tctgccgcct gctttaaacg gcgctccagc ggataaaatc ggcaggttct tgtactcggt 807841 atccttcatt tctttttcag cgtaccactt ttgcgcgtca gtcacgatct gaatggaagg 807901 atcatctttg acctgtgcaa agaagctgtt aatatctgct tcggttttgc cgactggctt 807961 tcggacatac tccagtgtgt tttggtgtgt ttgctgaatg gtgtttgtaa cggtttcgtt 808021 tcttgatgtg acgttgccag caatagattc aatacttcct ttggaatctg ctaccttcca 808081 tgagccgtcc gccttttcaa gcttgaggtc aatcacgcct aaatatttgc cccagctgct 808141 tggcatgacg acaggaatgc cgttaattgt tcccttttcc acattgaact gagcaacacc 808201 cgcatactcg gcggaaggaa agagtccgtg ctgatggccc gagataatcg cgtcaatgcc 808261 tttcgttttg gtggcaaggt caaacacggc gttttctgcg cctgatgatt gcgcctgctt 808321 ttcaatgccg gtgtgggcga gggcaataat gacatctgcg ccttccgcct tcattttcgg 808381 gatcgtttca ttggcggatt ctacgatatc ctgcacctga acttgcccct cgagattctt 808441 tttgtcccat gtcatgattt gcggcgggac aaagcctatg tagccgactt ttactttctg 808501 ctcattaccg ttttcatcaa tgagggtttt ttcattaatc acatacggcg tataacggtt 808561 ttcgccgcta gttgttttga cgttggcatt tacaatcggg aaatcggctc ctttgattgt 808621 gccgtcgaga aagtcgagcc cgtagttgaa ttcatgattg ccaagcgttc cggcgtcgta 808681 tttcagcgca ttcatgacgc tgataatcgg atgggttttc gtgccggaga taatgtcgtc 808741 tttttgatat ttcaccgcgt attcacccag cggattccct tgaatcaagt cgccgttatc 808801 cacaagcagg gtgttagggt tttgctcgcg gtgcttttgg atcaattgcg ctgttctcgc 808861 cagaccgaaa tccgccgttt ctttgtcgct gtagtaatcg taatccatca tgttggcatg 808921 aatatcagtc gtagccaaaa tactcagatg cacctgagga gccgcgcttt cttctgcatg 808981 aatgggtggt gttgggagga ttaggctaag tatcataatt gggggcaaaa gaatacggag 809041 aatgttttcg acgtgtgttc gtcttttctg tattctcacc agttctccac ctttcaacga 809101 aatttgtgtt acagctccta ttgtaagaat attttgtaac tatttgtagg tgtttcttta 809161 tgattattgt aaaagggaga aaaatgagta ttatgtagca gtatcaaacg acaaatactg 809221 ggcatttatg cttatcgttt gtcacaatcg cggaatgttt attttagtgt ggctggggta 809281 gagtgtttta tgtagacata taaagcggga ggttatgaat catggggaaa aaaattgcag 809341 ttgttttaac atattatttt gaggacagcg agtacactga gcctgcgaaa gcctttaaag 809401 aagcgggaca tgaactgact gtcatcgaaa aagaaaaagg aaaaacagta aaaggcaagc 809461 agggaacagc ggaagtgacg gttgacgcgt ccattgacga cgtaaattct tcagactttg 809521 atgcgctttt gattcctgga ggattttcac cagaccagct tcgcgctgac gatcgtttcg 809581 tccaatttac aaaagcgttt atgactgaca aaaagccggt atttgccatt tgccacggcc 809641 cgcagctttt aatcaatgcg aaagcgctcg acggccgaaa agcgacgggc tatacgtcca 809701 ttcgtgttga catggaaaac gccggtgccg acgttgtgga caaggaagtg gttgtttgcc 809761 aggatcaatt ggtcactagc cgcacaccgg acgatatacc ggcatttaac cgcgagtcat 809821 tggcattgct tgagaaataa gaaaaaacgg acgctcttgg gcgtccgttt ttttgttgct 809881 taggcttgag cacctgtcag tttcttgtac ctgtaataca agaaagcagc tgcagccgtt 809941 ccgatgaccg caatgccgaa gtcgaatatg aaaatatggg cgatgccccc cgcttttgcg 810001 ataagccctg ttgcaatcgg cagcagaatc gatgcaagac ttgaagcagt cgctacaatt 810061 ccggtaacgg ttccttttcg cttccagaaa agctctgtca ttaacgtaat ggtaatttga 810121 aacacacccg cagttgaaaa gcctaagaaa aaggcagtga tgtccagcac aactgggata 810181 tgaacggtca gcatgactgc gagcgtacat aaagtaataa taggatataa gagcgttatg 810241 aagacaggtt tgacccatct attcagcaaa acggctaata ataaaacaga tgccagagat 810301 cctatactat aatagctcag caattgtaca gatgctgatt cagctaaacc ggctgccttt 810361 tgcgcgtagc tcgggagcca gatttgagaa accgtaaata aagccgtgga tgtaaaaccg 810421 atgataatca gtgcggtgcc ttccttctga aaaacgggtt cagacaagaa aacgggagat 810481 tcctgttggc cgctattagt tggtttctta tgttttttag gaaacgaaag cgttgataaa 810541 taaataatat tcaggagata gaccgctgcc ggcagataaa aagcaaatcc gtaaaacatg 810601 ctgtggtctg ctaaaaatgt gatcaaaagc ggcaaaagtg cggcccccac agacataaag 810661 gctttaacca agacatttgc cgaaccggaa gcagacggaa agagctcggt tagggccgga 810721 tatgttccgg catccatggc tgaattagcg actccggcta ataaagcgaa cacaaacgcc 810781 agctcatagc tcggtgataa aggaataccg actaaaaaga cggccataat tcccgcagaa 810841 gcgacaacaa gcggctttct gccgatttta tctgatagaa cgccggaaat gccgtatgtc 810901 agcagtttgc caaacccgat agcggcaatg acataactga tgccggtcgg atcggtattc 810961 cactgttttg ttaatgaaga catattggat gcgagaatga tgttgaccat ccccagaaag 811021 aagtagttga tatacattcc ggatgctgtt ttgatagatg tcgtttgcat gcttgtactc 811081 cttcaaatct tattcgaaca ctttgctgtt ttggtttggg gaaatgataa aaaagactcg 811141 ccgagtttcc ggccagtctc cattatttac gaagcgaggc taattcttga gcaatcgcct 811201 gcatttcact tgggctgaat gattcttttt tcatcaccat tctgtgaagg tacgtgaggt 811261 cttcaatctt ctcatcactg aaatcctccg ctttgattac gccgacgttc agcatgttca 811321 gcttttggga aatctcttca atcatttgag ttaatgtttc tgtatttggg ctggacaaag 811381 ggttccatcc tttctatgcg caatataggt atgttttatt ctaacagaat tccatcagaa 811441 aaaaacccta ttctaaaagc aggctgttca ttccaaaaaa gtgaagacat cagttgaaaa 811501 gaaaatgaac atcctactaa gatattcatg aaggtttctt tttagagaaa taggggcaaa 811561 gaatagggag gttgcacatc atgataagcg tgttatttgt ttgtttaggt aacatttgcc 811621 ggtctccgat ggcggaagcg atttttaggg acctggcagc caaaaaagga ttagagggga 811681 aaatcaaggc ggactcagcc ggtattggcg gctggcacat cggcaacccc ccgcatgagg 811741 gaacgcagga gatattgcgc agagaaggaa tcagctttga tggcatgctg gcgcgtcaag 811801 tcagcgaaca ggatctggac gattttgatt acatcattgc aatggatgca gaaaatatcg 811861 gaagtctcag aagcatggcg ggttttaaaa acacctcgca tatcaaaagg ctcttggact 811921 atgttgaaga ttcagatctg gctgacgtac ccgatcctta ctacacaggg aactttgaag 811981 aggtctgcca attaatcaaa acgggctgtg agcagttgct tgcatccatt caaaaagaaa 812041 aacaattgtg agtgaaagga gaatttgcat gaacaacgaa cgtttaatgc tgaaagggat 812101 atttctcgga gctgcggcag gcgcggcgtt atcactgctc cataagccga caagacaggc 812161 gtgcgggatg agatggctga catgcaagca taaactttca ctgtacaaaa gcaacccaga 812221 gctgttaaaa aacactgtca tcacaaaagt ggatgaggcc aaaaagctcg cccgaacgct 812281 ttcaaaggaa gtcgactttg tgaaccagca ggtgaaagag ctgaagaaaa caacgccgca 812341 agtgatggaa ctcgtgcaag aaacgaaaga gcatttttca aaaaaatgat caaacatgcg 812401 aggtgagacg acatgagttt tttgaaagag cttttcagca gatacaccct tcatgaagga 812461 caaagtaaat cagcggagct ggcgtatttt tttctattgt cactgtttcc gtttttgatt 812521 tttatgctga cgctcaccgc gtatcttccg ctttctaccg atgatgtttt aggagtcata 812581 gaacaatatg ctcccgccag tgcgatgtca ctcgttgaat ccattaccca tcaaacctta 812641 aataatcgaa atggcggttt gctgtcattc gggattatcg ccgcattatg gtctgcgtct 812701 aatggaatga atgcgatcgt ccggtcgctg aaccacgcgt atgatgtgga agaaaaccgc 812761 tcttttatca ttgttcgtct aacctcgatt tttttgacga ttgccatggt atttacgatt 812821 ttagtggctt tgcttctgcc ggtatttggc cgggagattg gaaggctcgc ttctgacttt 812881 gtcggcgcgt cggatctgtt tttatccgtc tgggccgcca ttcgctgggg tgtcagcccg 812941 cttgtgcttt tgattgtttt ttccgcgctg tatgtgattg cgccgaacaa aaagctgtct 813001 ctccggtttg tcatgccggg tgcggtcttt gcgactatcg gctggatcat tgtcagcaca 813061 ttgttttcat tttacgtcag cacgtttgcg aactatagcg ccacttacgg gagcatcggg 813121 ggaatcatcg ttctgatgat ttggttttac ttgagcggca ttttaattat cctaggcgga 813181 gaaatcaacg ctcttttaca taaacgtaaa aagcttcctg atgaaaatcc ctaccattag 813241 cgcaccctat aaacgaactt cggttcaaaa agaagtcggg gggatatcgt gatgaccaag 813301 catacgaaaa aaggcggaag ccataacaaa caaaactcga aaagcaaatc gagccataaa 813361 acaagcggaa gcgccaacgg acaaaacggc taccattagc ataaaagcct cctgacatga 813421 tgtcgggagg ctttttgatt aagaagatga agaataggtt tcagccggtg accagctttt 813481 cggtttgccc agcacaaggg ccagccacac agagctaagc gtgagagtaa tgaagtagaa 813541 caagtttgcg ctttcaaatg tctgcatata ccagccgccg gcaactgggc cgaggatgct 813601 accgagactg aatgtaatgc cgcaaagcag gtttcccgcc ggcaggaggt gaggcggaag 813661 aaggtctgtc atatagctga tgccaagtgt aaaggttgat ccgactgcca ttcctgcaat 813721 aaaaaagcag ccgccgatca cgtagggcga aggaaataca ccggcgatga aaaagcaaag 813781 agccccagtc agtaaaatca ccagcagcac attccgcctg ccgtatttat cgctgaggat 813841 gccgagcgga aactgaaaga taatgcttcc aatcgcaaat gcgggaagga tgatcgctac 813901 tgcgtctact gatatcccca aacggagcgc gtacaccgga aagcttccgt tcagcgccgt 813961 ttccagaaag ccatagccaa atgtaggcat aaaggcaacc cacccaaaca gcatggcctg 814021 ataaaatcgc ctgaaactat tgtctgattt ggtttcatga ggactggttt ccgggtatgc 814081 attttgtaga aagaaaacaa aaagccacgc aaacagactg atgcagccgg acacgataaa 814141 aggaagcgac ggactcagct tgacaagcgg caccatgaac gggcctgcgg caaagccaag 814201 gccaaaggaa agcccataaa tagacaggtt tcttccgcga ttttgttttg atgacatgga 814261 ggtcacccac gtttgcgtag aaaagtgaag catgtggtcg ccgattccaa tgaacaggcg 814321 aagcaggaac cagacccaaa ctgactgaag ccaaataaat ccgaataagc ttaaaatgac 814381 aatgcttccg cccatgacga tcagcggctt gaacccgagc tttctgagcg gtgcttccat 814441 aaacggcgaa gccaaaagca caccgatata cagcccggtc gcgtgcaggc cgttgatagc 814501 agcggattct ccatttgttt caaaaatgat tgaaatgaca ggcagcagca tgccttgtga 814561 aaacccggaa atggaaacga gcaagacaag gataaagaaa tgaaatcgtg acatcgtgtc 814621 agttctcctt atatggaatc tatgttgatc gtacaacgtt ttccaaaagc aggcaacctg 814681 aaaaaagcct atatcacgct atacatttgc cctcgtgtaa tcatgaaggt ttttgtgaag 814741 aataaaaata aaacaagtca taaaaaagga gctatttcac catgaatcgt atctttttta 814801 ttttagtggc ggccggtgtt ccgctttctg tgattggcag tttgatgcat tggccttccg 814861 cggttctatt tgcagtttat tgcgtgacga ttatcgcgct tgcaagctat atggggaggg 814921 cgacagaatc actgtccatc attgcaggac cgcgtatcgg cggtttgttg aatgcaacct 814981 tcgggaatgc ggtggagctg attatttccc tttttgcatt aaaagaaggc ctgacaggaa 815041 tcgtgcttgc ctctttaacc ggttcagtgc tggggaacct gttgctggta gcgggcctat 815101 cgttttttgt cggcggttta aaatataagc ggcaggaatt taatatccat gatgcccgcc 815161 ataactccgg gcttctgatt tttgccatca ttgtcgcctt tgtgattccg gaggtattct 815221 ctgttggtat gggaaacgcc agcaagctca atttaagcat cggcatcagc atcattatga 815281 ttctgttata tgtggcggcg ctgtacttta aacttgtcac gcatcggggc gtttatcagc 815341 cgaataatgc cgctcagact gaagaagagg aagagccaga atggtcaggg aaggttgcga 815401 cgattgtctt gtttgcggca acgattgtgg ttgcatacat atccgaaaac ctggtccata 815461 cctttcactc ggtggctgaa cagttcgggt ggagcgagct gtttattggg gtcatcatcg 815521 tggcgattgt aggaaatgcg gcggagcatg cgtcagcgat tattatggcc ttcaaaaata 815581 aaatggacat tgctgttgaa attgcagtag gctctacgct gcagatcgct atgtttgtcg 815641 caccggttct cgtcatctgt tctatctttt ttccgacaag catgccgctt gtatttacat 815701 tgcctgagct cgtcgcgatg gtatcagcgg ttctcttgat gatcgcgatt tcgaatgacg 815761 gggattccaa ctggtttgaa ggggcgacac tgcttgctgc atatgtcatt atggcgatcg 815821 gctttttcct tctttaacct gaaaaaatga tggataacaa caaagcggga tgaaaagact 815881 aagggaaaat gccatagaaa gagtgatatg atgaaaaagc tatttcattc cacacttatt 815941 gtgttgttat tctttagttt tttcggcgtt cagcccatcc acgcgaaaaa gcagtttaag 816001 gttcctaatt ctgtcgcaag catttcaaag gaaaacacgt atccgaatgc ttcacaggat 816061 cagccaatgc ttcagccgag caagctggca aaggaattgc tcgatcattc tgaggtaaag 816121 attgaaaatc cgcatctcat caaaatgctg aatgaatcca acatatccgg cacaccgctt 816181 gcagtagggt accgggcgac aatatttctc gggaaatggg cgctcggcta tgaatcaaat 816241 gaaacagtcg caaactggga atataaaaaa atcaatacaa accgtgcgga taaccgcggc 816301 gggaaagaaa cggctgaaat gcattatgcc caggaacagc agtacagagt gaagggcggc 816361 ttgacagcta aagttccaaa tgctgaagat gtcaaaagca tgatgatgca aaaagcaatg 816421 aagaaaacga acctcccgct tgcatttgag acggtcatcg gggctggcac aaaacgggat 816481 cagatttata aagtcgctcc taaaaaaatc ggttatctac atgcatatgc accggctgtg 816541 aatgaaaaag gaaaagtgac ttacggagaa gtgtacttag tgctgaaagg aaataaacga 816601 aaactcgtcg tgaaaaatgt cacgtcacag ggaatcggcg cgtggattcc ggttcaagat 816661 catgtcacgt ttggctttca gctttcctca ctgccaagat aaataaaaaa ctgattccaa 816721 ctcggaatca gtttttttgt ttattgggtt ctctcgattc ggaccgcttc ctcaagcatt 816781 tgcacattgt tttggtagag ctggcgaacg agaacccgtc ttactgcaag gctggcactg 816841 aaataatcat catctttcac catgccttta accgtaaatt cgacgccgcg attgatttta 816901 ttcaatgcgg tgatgccgtg gatttgaaac ggttctgtcg gattgccgaa ttcatcccgc 816961 ttcaatgaat cacgaagctc ttcattcagc atgtcacatg cctcttccaa cacgctgtac 817021 acgcggtccg gatcttcttt aaagctgata agaaaggatt cggtaatccg cataaaatca 817081 atattatagt tctctatttg tctgacctcg ccgttgctga tggtgagcag cttcccgctc 817141 cattcccgga tttgcagcga gcggaggccg atttcctcca ctgtcccgtt gaacaagttg 817201 ttgacggtga cataatcgcc tttgtgcagc tggcgttcat atattaagaa tacaccagcc 817261 agcacatctt tgatcagcga ttgggcgcca aaaccgatca cgatacctgc tacgcccgcc 817321 ccggccaata tcttgccgaa atcatgcaca aataaagaaa taacgtaaaa gataaaacca 817381 attgttgccg tatactgggt gacagaacgg acaaggcttt caatcgtttt ttcctttttt 817441 tcttcaataa agtccgtccg tttaaaaaat agctgtacca gccggttgat gataaagaca 817501 ccgatccaaa ggataacggc aacgaggaga atatcgacga ttttattttg aaaaatctcc 817561 gtaagtgttt ctttcatccg catctaactc ctggcttgac gttttgtgaa gtctgtatcc 817621 tgataataac tgtttttgac aagaacattc ggtccgaggc accggacatt cgggcagtgg 817681 caactcagtt ctttcgcaag cttggtctct ctccactttt cataggcgga agggaggctg 817741 tccgtctgaa tgttgccaag cggcggggta tcaccgaaat cggtcacgat aatgtttccg 817801 tcgaaaatgt tcacattcag gcgggatcgg ccgtcagggt catttcgcac tgtgacgttt 817861 ttcgccgcgc gaagccggcg aagcagcttt tggtcgtctt cgtccggact gcaggcataa 817921 aacggcagcg ttccgaacag catccacgta ttttcatcac gaatatccag caagcggtga 817981 atggcctgtc tcatctcttt caggctgagg gattcaagag cgcttgcgaa atcgcttgga 818041 tacattgggt ggacctcgtg acgctgacat ttcatatctt ctgtgatttg gcggtgaata 818101 tgctcaatat gcggaagtgt tcgtttgttc agcatcgttt ccgcagatac cattactccg 818161 gcatccacga gcgtgcggct gttttcgatc attttttcaa aatagcgcgc gcgctgttcg 818221 aaggtcggtt ttctgtccat catggcaaag ccgatttcag caaaatcttc aactgttccc 818281 cagttatgtg aaatatgtag cacatcgaga tacggaatga tccattcgta ccgctcgatg 818341 tcgagggtca gatttgaatt aatttgtgtc cgcacacccc gttcatgggc atatttcaat 818401 aaaggaacaa catattcttt tactgatttc aacgaaagca tcggctctcc gcctgtgatg 818461 ctgatggatc tgaggcgcgg gatttcctcc agccgtttta acagaagatc tattggcaga 818521 gcattcgggt ctttaggctg caatgtatag cctacagcac aatgctcgca tctcatattg 818581 cacagtgtcg ttgttgtgaa ttcaacgttt gtcagctgca tgtctccgta ttggtcaaca 818641 tccatatagg cttcccaagg gtcaaactcg ggcgtaatcg gacgcagctt cgtgttttgt 818701 gtcatgacta tctaactcct ttataaatgg gcatactaac gctgccaaca gttaatttta 818761 gacctgattt gccaagatcg caagtagcgc ggcgattgaa aaacggcaaa aaatgagcta 818821 ccataataaa aaatgaatgg aggaacagaa tggggaacgc cgtaaacaat aaagatcagc 818881 agattgatta tttaaagaac agacttgaca tgtttatgaa cgtcatcgat tcattagacc 818941 ctgaagcaac cgacgttgaa gatatagaca ggcttatcag catgcttgat gacctggaag 819001 ccaaatacga acgttttaaa aaagattggg aataaaaccg cgtgcccgcc gcggtttttt 819061 tattggcata aagcaacagt ataaaacaaa gtctctatct gtaaaataag aaaaaatgca 819121 gaaggagcgc tggccatgaa gtggatgtgt tcaatatgct gcgccgccgt attgcttgcc 819181 ggaggtgcag cacaggcgga agcggtgccg aatgagccga ttaattgggg ctttaaacga 819241 agtgtcaatc atcagccgcc agatgccggg aagcagctga acagtttaat tgaaaaatat 819301 gacgcgtttt atttagggaa tacaaaggaa aaaacgattt acttaacgtt tgataacgga 819361 tatgaaaatg gctatacgcc aaaagtgctt gatgtcttaa aaaaacatcg cgtaacagga 819421 acgttttttg tcaccgggca tttcgtaaag gaccagcctc agctgatcaa acgaatgtca 819481 gatgagggcc atattatcgg caatcattcc tttcaccatc cggatttaac gacaaaaaca 819541 gctgatcaga ttcaggatga acttgattca gtcaacgaag aggtttataa aattacggga 819601 aagcaggaca acctgtattt gcgtccgccg cgcggcgtgt tcagtgagta cgtactgaaa 819661 gaaacgaaac gcctcggcta tcaaaccgtt ttctggtcgg tcgcttttgt tgattggaaa 819721 atcaacaacc aaaagggaaa gaaatatgcc tacgatcata tgatcaagca ggcgcacccg 819781 ggagccattt acctgcttca caccgtatcg agggacaatg cagaagcgct ggatgacgcg 819841 attacagatc tgaaaaaaca gggctacact tttaaaagca ttgatgatct gatgtttgag 819901 aaagaaatga ggctgccgtc tttgtaaaag agaaagacct ctccttaaac ggagaggctt 819961 ttctttattt tatacattta atcagtgcgg cccagtccag atccccgaag cctttctcaa 820021 tcccgctttc aaaatggctc ttggccagct cggcaagagg aagatttgca gaaacccgtt 820081 ttgcggcggc gagtgccagg ttggtatcct tcagccctaa agacattttg aagccggccg 820141 gctcaaattt ctgctcggcc ataatggttc cgtaattttg atagactgga gaaccaaaga 820201 gcgcgctggc gatttctaaa aattgttttt gttctaagcc gtatttctcc atcattaaaa 820261 aggattcaga taacgcctcc agcatggaca caagcaagaa attaatgctg attttggctg 820321 catttgccgt cttgctttct tcgccgacgt caaatatctg ctggctcagg ctgtcgagca 820381 gaggcttggc agcttgcttt gcttccgccg gtccggctgt tatgatacgg agcgcggctt 820441 tggctgcggc atccggtctg ccaaggacag gagcggcgag aaaaaattgt cctttctctg 820501 catgagccgc tgcgagcttt tctgagaact caacactgat tgtgctcatc gagatgtgta 820561 tgccgttctc tgctaatcct tcaagcagcc cgtcttctcc gaatgtcacg gtgctgacag 820621 aatcatcatc tgcaagcatt gtgatgacaa tatcagcgga ctttgccgcc agccgcggcg 820681 tatcagctgc ctgtgcgcct tctgtgacaa ggtcttctgt cttttgtttc gtccggttat 820741 agacagtcaa ttcgtagcct gcttgaagaa catttcgggc aatgggctgt cccatattgc 820801 cgagtccgat gacagcaatt ttcaatctaa tcactccctg aatatttttt ccattataaa 820861 caatatgaac agaatatgca tagcgatcgg cttacaacaa aaaagaacag ctgctcgctg 820921 tcctcattta aaaatattga accatccttt atgtacaaac caaatcagca ttccaatcac 820981 aagcgcggcc atcaggccaa gtacagcgaa atatccgtat ttccaatgca gctccggcat 821041 aaagtcgaag ttcataccgt atacaccggc aataaaggtg agcgggatga aaatggttga 821101 tacgatcgtc agtgtcatca taatcgcatt catccggttt gagtttagcg tcacgtagct 821161 gtcacgcaag tcggacgtca tgtcacggtt ggattccaca atttcagaca actttaacaa 821221 atgatcatat atgtcgctga aataggcttt cgtttcccgc tgctctttca catggtcaag 821281 gcttaaaatc cggtagagca aatcacgcat cgggataatc gtccgtctca aatgcaatag 821341 gtctgttctg agatcaaaca cctcgttcat cagcgttcca tacgttttgt ggggacggct 821401 ttcttcaatt tcattcagcc ggtcttcaat tttatacacg agaggaaaat attcatcaac 821461 aagctgatcc atgatcatat aagaaatatg cccgggccct tttttcaata tgtccggtga 821521 agcatacaaa cgctcccgga ctttagcgat accgggcgtt tcgtgtaaat gaaaggtgac 821581 gacaaatttt tcgccttgaa agatatcgac ttcctccgtc tcaagtgttt ccttattcag 821641 cgcatgaatc acgtaaaaac gatagccgtc ataatggtca agctttggcc gctgcatatg 821701 ctggaagcaa tcctcaatgg caagcgggtg aaaatgaaaa aaatctctca ataacgccgt 821761 ttccgtatcc tccgggccgt aaaaatcaac ccagtaccat gcaatatcag gctgttccac 821821 tcgttcgatc ggtatatttt tcagcagctg atgctctgtt gtgattgcgg taatgttgat 821881 cataaacaac cctccacctg ccattatatc atgcggtctt tatgagaaaa gtatacggta 821941 ctctctgcct aattccagcg gcatgttata ctgaacaaaa acggaaaaaa gggtggatct 822001 catgtggaag gaaaaagtat ctgtcacgcc tccgtatcat tttgaccgcg tgctggacag 822061 gctgtcttta gaccccctca atgctgttga tcgagaggcg agggaagtcc gtgtgccaat 822121 cagaaatcaa gcgggggacg tatgtattgt aaaggtacag gcgttaggcc atgcgggcga 822181 gcctgagttc ctcgtcagcg gggaaacgga tcagggagaa atgatgaagg aaatcaagcg 822241 gatttttcaa tgggaaaatc atttgcagca cgttctggat catttttcaa aaacgagcct 822301 gtccgccatt tttgaagagc atgccgggac gccgcttgtt ctggactaca gcgtgtacaa 822361 ctgcatgatg aaatgcatta tccaccagca gcttaatctt tccttcgctt acacgctaac 822421 agaacggttt gttcatgcgt ttggcgagca gaaggatggc gtgtggtgct atccaaagcc 822481 ggaaacgatt gcggaactcg attatcagga tctgcgtgat ctgcaattca gcatgagaaa 822541 agcggaatac accattgata catcaaggat gatcgcagaa ggcacactca gcttgtcaga 822601 gctgccgcat atggcggatg aagacattat gaagaaactg atcaaaatca ggggtatcgg 822661 cccgtggacc gtgcaaaacg tcctcatgtt cggacttggc cgtcccaatt tattcccgct 822721 tgccgatatc ggcctccaga atgccatcaa acgccacttt cagctggacg ataagccggc 822781 aaaggatgtc atgctggcga tgagcaagga gtgggagcct tatttaagct atgcgtcttt 822841 gtatttgtgg aggagtatag aataattcgt ctgacaatga aggaaatcct gcaaacgtgt 822901 tatactagaa agatgtgaaa aaaccatttc actttctgcc atccgcagaa agcttcatat 822961 agaaacggag agaacaacgt gaaccaacaa aagaaacagg cgcccgtcga actgaaggtc 823021 ggacaaactt ttccgctgac gattaagcgt ctcggcatta acggagaagg tgttggctat 823081 tttaagaaaa aagtcgtctt cgtgcccggc gcgcttcctg gcgaagaagt tgttgtgcag 823141 gccacaaagg tccagccgaa gttttcggag ggccgcatta agaaaatccg caaggcatct 823201 gagcaccggg tggcaccgcc ttgccctgtt tatgaacaat gcggcggctg tcagcttcag 823261 caccttgcat acagccagca gcttcgggaa aaacgtgata tcgtcattca gtctcttgaa 823321 cgccatacga agtttaaagt tgaaaacatg gaaatcaaag aaacgattgg catggacaac 823381 ccgtggaatt accgcaataa aagccaattc cagatcgggc gctcgcaaag cggcagcatc 823441 atcgccggct tatacggcct tgattctcat gatatcgtgc cgattaaaga ctgtatcgtt 823501 cagcatccgg caacgaacaa aacaacaggc atcgtccgcc gcattttaga ggacttcaat 823561 gtgtctgttt ataatgaaag aaaacgaaaa ggcgacgttc gcacgatcgt gacgagagtc 823621 ggctttgaaa caggcgaagt gcaggtcgtg cttgtaaccg caaaagaaac gcttccgcac 823681 aaggaagaaa tcgtcaaagc gattcaaaag cgattgccag aggtcaaatc cattattcag 823741 aatgtaaacg gggcgaaaac ctcagtgatt tttggtgaga aaacaaaaca gctcgccgga 823801 aaaacagtga ttcaagaagt gctcggcgac gtatcttttg aattgagcgc ccgcgctttc 823861 ttccagctca atccggaaca gaccgtcaag ctgtatgatg aagtgaaaaa agcggcgcag 823921 ctgaccggaa aagaaaaagt cgttgatgcg tattgcggcg tcggcactat cggcatgtgg 823981 gttgcggacg gagcgaagga agtccgcggc atggacgtca tcaaggaatc aattgacgat 824041 gctaagaaaa acgccaaaaa acacggcatg gcaaatgcca catacgtaac aggaacagcc 824101 gagcactggc tcccgaaatg gacgaaagaa ggcttccgcc cggacgtcgt cattgtagac 824161 ccgccaagaa cgggctgtga cagcacgttc ttggacacga tcaaaaaagt caaaccgaaa 824221 cgctttgtct acgtttcctg caatccatcc acgcttgcga aagatttgca gacgctgtcg 824281 aaggactatc gcgtggacta tattcagcct gtcgatatgt ttccgcagac ggcgcatgtt 824341 gaagcagtgg cgaggcttgt attaaaatcg tctaactaaa aagaacattt cccagtcata 824401 aaatagtttt cctaataaga cctggatttc ggtaaaataa acaattccga tttccgggtc 824461 tttttcgtgc gcagctcttg tcctaacggt ctgttctcaa ttttatcttc cttcttttcg 824521 cggagatctt tattttaact ggcgaaaaga attgaaaaaa cgtgttgaaa agcaggtgaa 824581 aaaaagcgtt atttaaccgg aaaaatatcc tcccagtatg tttaaaatac atgagtagaa 824641 tgatgtaaaa tcatagatgt attttcataa tttgtaaaat tatatattga cttgcagtta 824701 ttacgtgtga aatattgatg ataggaatat aaggaaagta tggcgtatat catttcaaga 824761 gtcattcgat gtaaaaagtt gaaacattgt aataaatgaa agaggtgaaa atgatggcca 824821 accccatttt aaaatgcata acgtatgagc actacaacaa ttaaataata gtgccgagac 824881 gataacaact attacagtaa tacctacaat ggttatatcc ttgcgacaat catgcttcat 824941 aatataatga ttttagattg acacttggct aaaaagtatt gcagagaagg aaatggataa 825001 ttaaatggat aaagtatata aaagaagttg gtttcaaaca tttttggcat ttttagtatc 825061 tcagctttat tttaattttg tagaattaac gggatggggt cctaagtata gagaaatgaa 825121 tggattccca gcaaacatag ttgaactaga tttctttcaa acatatcttt cattctatga 825181 taatccatgg tttaatatta ttactgtttt cttgggagtt ttcactatta tacaaataat 825241 tacagggata acaaaggata ttcgaaatta aagcaataac ttctgatgcc ttatttaatg 825301 atgaaagaaa atgtacactt tcttaattat cttatgagtg aagactgcga cacttagtca 825361 gcagtctatt ttatggttct ggatcaggat taccgaatta taaccctata caaatatata 825421 gtaggttgcc acttgctgcg ttggttattt tctaaatcat gagcaaatcc caaatgattc 825481 agattgaagt tcttgaattc ttttaaataa gggtttattt tctcttctca tcctctttac 825541 tccatgtgat tcacaagtgg tagcagctta agtaggtttt ttcattctct tgagtactca 825601 gttataccac ccccaactca atttgcttta tctctattag tttttccgca aatatgatat 825661 agagatacgg atatggtgta gtgttaaata tcttatcttc aataacaggg caattatttt 825721 gcgttggtaa tatggagaac tcatatgata ttctatttag gttggaatcc tttttatcca 825781 aaaagttcaa aagcaaggcc actaagaaag acgaaggtca gcgccagtta accagaatat 825841 aaaaaatagg gtagataatc atcccacgtg aaatcttcaa aatttactat agattgataa 825901 gaaatgcttt cgcatgcgat aagtgtaaaa gaagcatggt cagtttttaa tttgggataa 825961 aggttcagcc gtatcccata atgaaaggat ttgatttttg ttatgacaga aaatttctgg 826021 cgtgaattac cacggccgtt ttttgtactg gcaccaatgg aagatgtgac agatgttgtt 826081 ttccggcatg tagtaagtga agcaggcaga ccggatgtgt tttttacaga gttcacaaac 826141 tcagagagct attgccaccc ggatgggaag gatagcgtgc gcggccgttt gacttttaca 826201 gaggatgaac agccaattgt ggcccatata tggggagata agcctgaaaa cttccgtaaa 826261 atgagtattg gcatggcaga gttaggattt aaaggactag atatcaatat gggctgccct 826321 gtgcctaatg tggcggggaa tggaaaggga agcggcctta tttgccgtcc tgcagttgcg 826381 gcagaattaa tacaagctgc aaaagcaggg ggattgcctg taagcgtgaa gacaagactt 826441 ggatacacgg atgtggatga atggcgcgag tggctgacac acattttgaa acaggatatt 826501 gcgaatcttt ctattcatct gcgtacaagg gcagaaatga gcaaagtaga tgcgcattgg 826561 gagctcatcc cagagattaa gaaacttcgt gacgaggtgg caccagatac attgctaaca 826621 ataaacgggg atattcctga ccgtcaaact ggcttgaaac ttgctgaaca atacggcgtc 826681 gatggaatta tgatagggcg cggtattttt acaaatcctt tcgcttttga aaaggagccg 826741 aaagagcata gcagcaagga attgcttgat ctcttaaggc tgcatctgga tctccatgat 826801 gaatattcaa aagaagaagc ccgtccatac aagcctcttc ctcgcttttt caagatttat 826861 ctccgcggat tccgaggggc aagtgaatta agaaatcaat gcatgaacac aaagtcaaca 826921 gatgaagtgc gtgcattgct cgacgacttt gagagaaagt atcttgatgg gatagagtaa 826981 cagcagtgct tgattcaaaa aaggctaaca aaataaaggg atttttacac aattcttgac 827041 taaaataaac ctggattttc ggtaaatccg ggtctttttt gtacgcagct tttactcagc 827101 ctgtcttttc tctaatttat tgtaagaaaa taatggtata tttagtggag atatcatata 827161 aagggggaga ggaaaatgaa acggctatgc atcatcccct gcggcaagaa aaaaatctgg 827221 gatgtccagc ctgatgccgg gccggtaaga gcagaggacg cttatctcag cccgtttcat 827281 caggcgtgcg agcggtatgc aaaaacattt ttcgatgagt gggtgatttt gtcggcgaag 827341 cacgggttcc tccgccctga tgatctcgtt tcgggaaatt acgatgtcac ttttggcacc 827401 ggtcatccgg aaatcatgac agcggacgag ctgcgccgtc aatttcacga aaaaggcttt 827461 tctgatatcg aagagctagt catgcttggc ggaaaaaaat atcgaagcgt tctaaacgcc 827521 gtcatcggag aacaccagca tatcagctgg ccgctatcat catacaaagg cataggctat 827581 atgctccaag cgctgaaccg ggctgttgaa gaaaagcatg aactgtagca cgtacatatg 827641 aggaaaagag tgggaacatg aaaaaacttg tgtttggctt gcttgccatt gtgttattcg 827701 gatgcggact atatatctat catgtatggt tcggtgatcc attttcgaaa aatgctgcag 827761 aacagaagct agtgtcttat gtgaaacaaa cctatcctaa gaaagaaatc aagatcacga 827821 atggggtata taacgctaaa acgtctgaat atgtatttga agcaacctcc caatctcatc 827881 gctacccaat gtgtacgaag ggatttctgc atcctaaagt aacgtgcgat ggaattgaag 827941 aagcgtatac cgaatcagta gcaaaacatg taaatgaaga agcaacgaag gcaatcgaag 828001 cagatctgaa aaaagcggtt cctcgattta taaaagctga tgctgctttg agtatcgaaa 828061 acggacagtt cacgttagat acaaaatgga acaaaaagct ggctgaaaaa gcgcctatga 828121 gcatgacgat tcagttagac gccagcgggt tatcaaaaac agatgccgca aagatggcgg 828181 aaacggtcag aaaaacgctt aatgaaaagg gatatacata ctcaaacggc acgatagact 828241 gtatgcagaa ggacggggac ggcggtattg gatatgtcaa atattcaatt gattttcttt 828301 caaaagcagc tattcagtca aacgatgcag aggaactagg aagttaaaaa gatttccaag 828361 gaaataaata cgtcgatcat tgtcaaaggc cgggtgatat ccggtctttt ttttgcatgc 828421 tgtaaaacga gacaaatgaa tcagtttgag acaaaacgag acacacgtct caaactgtct 828481 ccaaagtgaa gatgagaaga ctgattttac gggctcaaaa gactggcaca cttcttgcat 828541 ttataatggt gaaccctaaa tagaaggagg cgcacaaaat gaaattgtta aaacgagaag 828601 gcttgtcatt aactgaggaa aaagcgctgt ggatgtacca aaagatgctg gagatcaggg 828661 gctttgaaga caaagtgcat gaactgttcg cccagggagt gcttcccgga ttcgttcatt 828721 tatatgccgg tgaggaagcc gtggctgtag gggtgtgcgc tcatttacat gatggcgaca 828781 gcattacaag cacccacagg ggacatggac attgtatcgc caaaggctgt gacctggacg 828841 gcatgatggc ggaaattttc gggaaagcga ccggattgtg caaaggcaag ggcggttcta 828901 tgcacattgc ggatcttgat aaaggcatgt taggcgcaaa tggaatcgtc gggggcggct 828961 ttacgctcgc atgcggatca gcgctcacgg ctaaatataa acagactaaa aatgtaagcg 829021 tttgcttttt cggggacggg gcaaataacc aaggtacctt ccacgaaggg ctgaatttag 829081 cggctgtatg gaaccttcct gtcgtatttg ttgctgaaaa caacggctat ggcgaagcta 829141 ccccatttga gtacgcatca gcctgtgatt caatcgccga tcgggcggct gcttataaca 829201 tgccgggggt tacagttgac ggcaaagata ttttagcagt ttaccaggca gccgaggaag 829261 cgatagaaag agcaagaaac ggcggcggcc cgtctttgat tgaatgtatg acctacagaa 829321 actacggcca tttcgaagga gatgcccaaa cctataaaac gaaggatgaa agagttgagc 829381 accttgaaga aaaagatgcc attcaaggtt ttaaaaacta ccttttaaaa gaaacagatg 829441 ctaataagct gtcagacatt gaacagcgtg tcagcgaatc gattgaaaaa gccgtctcgt 829501 tcagcgaaga cagcccatat ccaaaagatt cggagctgct gacagatgtg tatgtgtcat 829561 atgaaaaagg aggaatgtaa gagatggcga gagtcataag catgtcagac gcgatcaatg 829621 aagcaatgaa gcttgcgatg agaaaagacg aaaatgtgct tttgatcggt gaggatgtcg 829681 ccgggggagc ggcggtcgat catttgcagg atgatgaagc atggggcggt gtattagggg 829741 tcacaaaggg actcgtacag gaattcgggc gtacaagagt gctggacact ccgatttctg 829801 aggcaggcta tatgggagcg gctatggctg cggcatcaac cggtttgaga ccgattgccg 829861 agctgatgtt taacgatttt atcggcacgt gctttgatca ggtgatcaac caaggggcga 829921 aattccgtta tatgttcggc ggaaaagcgc aagtgccgat taccgtccgc accacatacg 829981 gagcagggtt ccgggccgct gcccagcatt cacaatcgct gtatggcctt ttcacgagca 830041 tccctggact gaagacagtt gttccatcca atccgtatga tgccaaaggt cttttgcttg 830101 cagcaataga agataatgat ccggtgtttt tctttgaaga caaaacgtcc tacaacatga 830161 agggcgaggt gccggaagat tattatacaa ttcccctcgg aaaagcggat atcaaacgcg 830221 aaggcaatga tgttacgctc tttgcagtcg gcaagcaggt caatactgcg cttgaagcgg 830281 ctgcacagct ttcagagagg ggcatcgaag ccgaggtcct tgatccccgc agtctgtctc 830341 ctctggatga ggatgcgatt ttcacatcgt tagaaaaaac aaaccggctg atcatcattg 830401 atgaagccaa tccgcgatgc agcattgcca cggatattgc tgcgcttgtc gctgacaagg 830461 gctttgattt gcttgatgcg ccgattaaac ggattacagc gccgcataca ccggttccgt 830521 tttcaccagt gcttgaagat caatatttgc cgacaccaga taaaattgtc agcgtcacgc 830581 ttgaattgct tggcgagccg gcattgaatt aaagggggga cacaaatggc ggtaaaagta 830641 gtgatgccaa aattgggaat ggccatgaaa caaggggaag tatcgatatg gaataaaaaa 830701 gtaggcgacc cggttgaaaa gggagaaagc attgccagca ttcaatcgga gaaaattgaa 830761 atggagatcg aagcgcctga aaaaggaacg ctgatcgata tcaaagtgaa agagggagaa 830821 gaggttccgc ccggcacagc tatctgctat atcggggacg ccaatgagtc ggtgcaggaa 830881 gaggcggggg cgcctgttgc tgaagacaat atgccgcaag ccgtccagcc cgtcaaacaa 830941 gaaaacaaac ccgcagcctc caaaaaagat cgaatgaaaa tatctccagt cgccaggaaa 831001 atagcagaaa aagcaggatt agacctaaaa caactgaaag gaactggacc aggcggacga 831061 atcgtgaagg atgacgtaac aaaggctctt gctgaacaga aaaaagatca agcaaagcct 831121 gtttcggagc agaaagcgca ggaaatcccg gtgacaggca tgagaaaggt catcgctgcc 831181 cgaatgcagg aaagcctggc aaacagcgcg cagctgacga tcacgatgaa agctgatatc 831241 accaagcttg ccactcttca aaaacagctt tcaccaactg cggaagagag atacggcaca 831301 aaactgacga tcactcattt tgtctcaaga gccgccgttc tcgctctgca agctcaccct 831361 gtgctgaaca gcttttatca aaatgagcgc atcatcacac atccccatgt gcaccttggt 831421 atggctgtag ccttggaaaa tggcttagtg gtgcctgtca tccgccatgc tgaaaagcta 831481 tcgctgattg aactggctca atccatctca gaaaatgcca aaaaagcacg cgagggacgt 831541 gcgggaagcg aagaactgca aggatctact ttctccatta caaaccttgg cgcgtttgga 831601 gttgagcatt tcacaccgat actaaatccg ccggaaacag gcattctcgg catcggagca 831661 agctatgaca caccggtgta tcaaggggag gagatcgtca gaagcacgat cctgccactc 831721 agcctgacat ttgatcacag agcgtgtgac ggcgcccctg ccgctgcatt cctgaaggcg 831781 atgaaaacat atttggaaga acccgcagca ttaattttat aggaaaagca ggtgaaaacg 831841 acatgacatt agccattatc ggcggcggac ctgcaggcta tgcggctgcg gtttccgcgg 831901 cacagcaggg cagaaacgtg ctgctcattg acaaaggcaa gcttgggggg acctgcctga 831961 atgaaggctg catcccgaca aagtctttgt tagaaagcgc aaacgttctt gataaaatca 832021 agcatgccga cagctttgga atcgaacttc cggcaggtgc gatatcagtc gattggagta 832081 aaatgcaaag ccgaaaacaa caggttgtca gtcagcttgt ccaaggcgtt cagtacctaa 832141 tgaagaaaaa tcaaatacag gttgtaaagg gaacagcctc ctttctttct gaaagaaagc 832201 tcttgatcga aggagaaaac ggaaaagaaa tcagagaggc ggaccaagta ttgattgcct 832261 ccgggtcaga gccaatcgag ctgccttttg ccccatttga cggcgaatgg atcctcgaca 832321 gcaaagacgc gctttctctt tccgagattc cgtcttcact agtcattgtc ggcggcggtg 832381 tcatcgggtg tgagtatgca gggctgttcg ccagattggg atcgcaggtg accatcattg 832441 aaacagcgga ccggctgatc ccggctgaag atgaagatat tgcccgtctc tttcaggaga 832501 aacttgagga agacggtgtc gaagtgcata cttcatccag attagggcgg gtggatcaaa 832561 cggccaaaac ggcaatatgg aaaagcggtc agcgagagtt taaaacgaag gccgattatg 832621 tgctggtggc gatcggcaga aaaccccgtc ttgacggatt gcagctggaa caggccggag 832681 ttgatttttc tccaaagggc attccggtga atgggcacat gcagacgaac gtgcctcata 832741 tttacgcgtg cggagatgct atagggggca ttcagctcgc gcatgccgct ttccatgagg 832801 gcatcatcgc tgcttctcat gcttccggaa gggatgtcaa aatcaatgag aaacatgtgc 832861 cgcgctgcat ctatacgtcc ccggaaatcg cgtgtatcgg aatgacagaa cgacaggcaa 832921 gaagcatata cggggatgtg aagatcggcg aattttcatt ttccgcaaac ggcaaggcgc 832981 tcattaaaca gcaagcggaa ggaaaggtca aaatcatggc tgaaccggaa ttcggcgaaa 833041 tcgtgggtgt ctcgatgatt ggcccggatg taaccgagct catcggccaa gcggcagcga 833101 tcatgaatgg tgagatgacg gcagatatgg cggagcattt tatcgccgcc catccgactt 833161 tatcggaaac attgcatgag gcgctgttaa gcacgatcgg ccttgcggta catgcataat 833221 aaaggaaaaa gcaggcgcat ggatataagg cgcctgcttt tttattgttg aaagcgcttt 833281 atttttcccc tacaatagat gaaaacggcg tgtaagggag gagcgatcaa ggaaatgaat 833341 tcggtcccaa acgatttgca aacctggaaa cgttttgtga aagacggtgt gcttgacgaa 833401 gcccgattaa gaaaacggat tgcagagtca tggcatcgct gcaaaaaagc tgaggtcaat 833461 ccttatttag aaaaaggccc gaaggtttta cagcaaacgg agctggatca gcagtcaaaa 833521 aaacattcat tcttcttgac gaccgcaaag ccttacctcg aaaaactgct gcctgccata 833581 aaagaaatgg aaatgatggc gctgttaatt gattcagacg gtgttgttct ggcattggac 833641 ggccatccgc gcgcgctcta tgaagccaaa cgcatcaatt tcgtcgaagg ggcatgctgg 833701 acagaaacgg ctgtcggaac aaatgcgatt ggcacggcgc tccacatcag cgagccggtt 833761 gcaatacaag gatcagagca ttactctatc gcttcccatc tttggaactg ttcagctgct 833821 ccgattcacc atgaggatgg cagccttgcg ggtgtaattg acatatcatg cccggcggca 833881 ggcgcgcatc ctcatatgct tggtattgcc acggcgattg cctatgccgc tgaacgggaa 833941 ctcgcagcta aaagccgtga gaaagagctg gagctgatca gccgttttgg ggagagagct 834001 gcatccagtg tgccgatggt gctctgtaat accaagcagc acatcatcag tgcgagcatg 834061 ccgattcgaa cctcaatgcc ggattggcag ggccggcacc tgtacgagtt gaaggaacgg 834121 ggctattcaa tcgaaaatgc tgtcaccata ggagatggcg gcacttgttt ttatctttcg 834181 gaacaaaaga aaaagaaggc gtttcgattc aatggagtga tcgggcaaag cggccgatcg 834241 caagcgatgc tgatgcacct tgaacgagca gctgcgacgg atgcatcggt ctgtttgtcg 834301 ggtgaaacgg gtacggggaa ggaggtcgcg gctcgcgcgc ttcatgagaa cagtgagaga 834361 cggcacggtc cgtttgttgc tgtcaattgc ggagcgattc cgtctgattt gattgaaagc 834421 gaactgttcg gatatgcaga gggcgctttt acgggagcga aacgaaatgg ctataaaggc 834481 gcctttcaaa aagcgaatca aggcacatta tttttagatg aaatcggaga aatttcccac 834541 tcgatgcagg ttgcactttt acgggtgctt caggaacgca agataacgcc aatcggcggg 834601 acgaaagaaa ttccggttga tatcagagtt attgccgcca cacattgtga tttacgcgag 834661 cttgccgaaa acggaaaaat cagagaggac ttgttttacc gtcttcatgt ctatccaatt 834721 gaactccctc cattacgcga tcgcaccgag gatatcccgg atctctttga gtactacaaa 834781 cagaagaatc attggccagg cgatcttcct tctgattttt gtaatgtgct gaagcaatgg 834841 aagtggccgg ggaatatccg cgagctgttt aatgtgtttg aacgtctttc tatcagattt 834901 ccggacggcc ggctgagaga tgaatcgctt cccgctttac tggaagccgc tggattgccg 834961 gccagctctg cagaaaaaaa gccggctgct gccggcgtgc ttacttttcg tgagcaaatc 835021 caaaaggata tgatgatcaa agcgcttgaa tctgcaaaag gaaacgtctc tcaagccgca 835081 aaaatcagcg ggatcccccg aagcactttc tacaaacgcc tgaaaaaatt caacttgtcc 835141 gctgaatcat aaagcatact tccttcagga aatggaaacg ttatgtattg aaggagggtg 835201 ttacgatgaa tattcaaagg gcgaaagaaa ttgtagaatc tcccgacatg aagaaagtaa 835261 catataacgg cgttcctatt tacattcagc acgtaaatga agaaactgga acagcaagaa 835321 tttatccgct tgacgaaccg caagaggagc atgaagtgca gctgaacagc ttaaaagagg 835381 attaaacaaa aatggcccgc ttcataagca ggccattttg ttatccgcgc ggcgcaaata 835441 aaataacaca gacaccgatg agacaaatga atgcgccgat ccagtcatac agatcaggtg 835501 ttttccggtc aacaagccat ccccacagga ccgcaagcac gatgaatact ccgccataag 835561 cggcgtatac acggccgaaa gatgggaagg actgaaacgt cggaagaatg ccgtatacaa 835621 tgaggatcag cgccccggcg attccgtagc cagctggctt tgcctctctc agccatagcc 835681 aaaccagata tccgccgcca atttcagcaa gccctgccgc gagaaataaa agaatggtaa 835741 tcagcatcat gagcactcct caatttgcat ttatctttca ttatagagga ggagagcttt 835801 taaagcttcg gatgattctc aaattccttc aaatacgctt ttcgctgaac ctctgtaaat 835861 tggctgatcc aattgttttg agcctcttca ttcaaatggg gaaggatata gcgttcaacc 835921 gcttcgaaaa acagcggatt cgtgatgatg ttccaggtcg ggattcgaac gattttgccg 835981 tctgttttct cgatgataat atcctcaaaa aagatccctt tcaaactgta ttgatggcgt 836041 cccatataaa gccgcttcac ctcggaaaac agcacgctgc gctttctcaa gaagatttcg 836101 ccactaggtc cggtctttat ggtgaaaatg acatttccac ggcttgtgaa cgcaggaaaa 836161 gccataaaga atgtgatcaa tccataaatc atcgccagta atccgccgcc caaataaagc 836221 agggcatatt tagattcaaa cgtgagggct tcagacacca gccagactcc cacaataaag 836281 gcgccccctg tagcgaggaa cagccaagcc cttagaaaca tcatgctttt tacttcaatc 836341 atgtgctgcc cctaaagctt cggatgattc tcaaattcct tcaaatacgc actgcgttgg 836401 atgtctgtaa actgtccgat ccaattgctt ttcgcctctt cattcagatg tggaaggata 836461 tagcgttcaa ccgcttcgaa aaacaacgga ttcggaatga tgttccaagt gggaatgcga 836521 atggtcttct gatccacggt ttggatcaat atatcttctt ggaagattcc ttttagacta 836581 aatttatggc ggctcatctc aattttcttg atatcagtaa acgtaacaga cactttgtca 836641 gtgaacactt ctccattttt tcctgtcttg atgcggaaaa tggtatttcc ccgcggggtg 836701 aaagccggaa agaagatgat aaataaatat aaacaaaaca aggtgaacag aaagccagca 836761 ggaatggcta ataggtaata tttcgtttga aacgtaatac ccatataaaa gagccacaaa 836821 catgctaatc ccataccggc agatccgaca aaagcccata ttctcaggaa cattttgctt 836881 ttgacttcaa tgatttcttg gtttttcaat gcttttctcc ttttgttaat tcaattctta 836941 tcattttgaa atgatttgat ttacaacatc cttatgagca gggaggatag aaaattcatt 837001 ctgggtgatg cctgtgacaa gccaagtatg gtgggccccc ggcaggacga atgccatgtc 837061 agccacttca ggagtgttat cttttccata tgccagacgc ataagtgtat ccattttccc 837121 tttccgcaaa gccagatcat ttgcaaatcg ggtaacgtcc tcttggtggt catgtttttc 837181 aaggaactct tttagatatg aagggttgtc tgaagcgccc tccaagagtt tttcaaattc 837241 atttgatgtc aatgttacaa tcgattctct tttatcctct gtatctatta tatgtaaaaa 837301 ctcatctgtc ttagcaagta acccttcact tgattccatt tttgtaatgc gatggacttg 837361 ttcatcaaaa aggagttcgt gagagtaggt gccgaatttt gatacatggc atgacacatt 837421 ctgttcggca ccttgcccgt taaatttaga aagcttcact gtatagtcag cgtcgtttaa 837481 tacatggata aacggacagt actcgtcctt taaccgatat tgatggttcc gatattccgc 837541 tgcatccttg gctaagagtg agcggcacgc ggcttcaaat aaggcgccga gctgttcatc 837601 ttctatttcc ggaaaatagg cctgcttcaa ggccattccc tgttcaaaaa acccttcgct 837661 gtaaaagcaa aacaagagtt cttctatgct aattgtaaac tgcttcattg tttattctcc 837721 tatccaaatg aaaatttccc tttaaggaaa tgggttgcgc cgtgtataag cgaatccgct 837781 gttttctttg ctttttccat tccttttttc gcgctgtcta tccctttatg tatcgattta 837841 ttcgccgcat ctatgccgtc attcactgat ttgacgactt tgccggctga ttccagccct 837901 tttttggctg tatcaacaac agcatggatc ggttctttca gctttaaggc tgctttttca 837961 gcaaaaccgg ctgtatattt ggcgatttgt tctccgacga ctccgccaat gtatgaacct 838021 gctgccccaa gaaggacagt acccacaggt cctgcaaagc ttccgattgc accgccgatg 838081 acagcaccag ctgtggcacc gccggcaaca aaaatcgtat tattcacagc attcccgacg 838141 gccttggcgt tttcacgctt gagaacttcc ggtttatcct ggtattttgc ataattttca 838201 gcaattttca cgcctgctcc gaatgtttcg gtcgctccgg taatcagtgt ggcggtaatg 838261 gcatttcctt tcgcgaatct caagcccgtt tttcccacat ccttcaaagt ggagcgtacg 838321 ccggcttcat taagaaatcc ttttgtgtag cttctgacgc tgtttgaaaa atccaccgtg 838381 tcctgaggaa agtattttgt aaacttttta tgtaccaaat ctgaaaatgg acggtttgtc 838441 tttttcaaca aatatttagg attcaaaagc actcttgccg ctttttgata acgtgagctg 838501 tcaacggccc tggaaatatc caagagcagt tttgagtgct gggctgtatg caagccgctt 838561 ggttgtttca caaatttcgt aagccctaat ccgtaatatt ttccctgcgt cagcataaga 838621 gcggttaagc ttgtcatcgt accgtatttg tcgtaggcat tgtagagctt tcgcaaaata 838681 tcatcttgtt ccacaaattt atcgcctgtt tttctgatga aaatctcatt gtcactcagc 838741 ttagtgacga gcgcctttcc tgagctccac gcatcgccca ctccagaaaa acagctgctg 838801 tagcggggat cgcattgcaa aatcatctgc cccagctcca catgcaggtc cttatatttg 838861 ttttccatat cagttaattc agtgactaca tcatttgcaa gctgttcgag cttatccgga 838921 tcaactgcaa tgtttcctga cacaccgttc acctcccgag tttatgtctt tcctctcttg 838981 ctttacgctc cagttcttcc attctggcaa tttcagcttt tcgttcttct attttgacag 839041 cggcagcctt cagctcttgg cttgtttcaa gcagctcctg ttcgaattga tcgtaggcgg 839101 ctttcgtttc ctcgaaatcc tggtcaaacg aatctcttgc tttgccctgc caagcatctc 839161 ccaatgcaga taaccgggat tcaagcagca ttttggagct tctgacctct tctgcggccg 839221 cactatactt gtttgccagc tcaatgactt tatatgagtc caacttttgt cccctgcctt 839281 ttctaaattc acgcacaatt ggatgtttta tataaatgat tataaataat tcggcatgta 839341 tccgaatcgt acaaaagaac cttttcataa gaattggaag ggcgtatatt cacttaaaat 839401 tcacagttgg tgagacttta agattacaaa aaaggtaaaa aaaccaaatc tctcagacat 839461 aaggcaaatg agaaatttcc cgctctatgg gaaaaaacac taaagttgat caaatgacct 839521 aagtgcgcca aacgtgttac gggacgagct atctcatggt ataaatggaa ttgtaaacgt 839581 tatcaaggag gtcgtcatat gaagaaaaaa tcattctcaa tcgtaatagc gggcggaggg 839641 agcactttca ctccagggat cgtactcatg ctcttggacc atttggagga gtttccgatc 839701 agaaagctga agctgtatga taatgataag gagagacagg atcgaattgc aggcgcctgt 839761 gacgttttta tcagagaaaa agcgccggat attgaatttg cagcgacgac tgacccggaa 839821 gaagctttta cagatgtcga ttttgttatg gcgcacatca gagtagggaa atacgcgatg 839881 cgcgcgcttg atgagcaaat tccgttaaag tacggagttg tcggccagga gacgtgcggg 839941 ccgggcggga tcgcatacgg tatgcgttcg atcggcggtg tgcttgaaat attagattac 840001 atggaaaaat actcgcctga tgcgtggatg ctcaattatt ccaatccggc ggcaattgtg 840061 gctgaagcta cgagacgcct tagaccgaat tctaaaattc tcaatatctg tgatatgccg 840121 gttgggatcg aagaccggat ggcgcaaatt cttggcttat cctcaagaaa agaaatgaag 840181 gtccgctatt acggattgaa tcatttcggc tggtggacat cgattcagga tcaagagggc 840241 aacgatttaa tgccgaagct gaaggaacat gtatcccaat acggttatat tccgaaaaca 840301 gaggctgaag ctgtggaggc aagctggaat gacacgttcg ccaaagcgcg tgacgtgcag 840361 gctgcagatc ctgacacact gccgaatacg tatttgcaat attatttgtt cccagatgat 840421 atggtgaaaa aatcaaatcc gaatcatacg cgggcgaatg aagtcatgga agggcgcgaa 840481 gcttttattt tcagccaatg tgacatgatc acacgtgaac agtcctcgga aaacagcgaa 840541 attaaaatcg atgaccacgc atcgtatatc gttgatcttg cccgggcgat tgcctacaac 840601 acaggtgaaa gaatgctgtt gattgttgaa aataacggtg caattgcgaa ctttgacccg 840661 actgcgatgg ttgaggtgcc atgcatcgtc ggctcaaatg gacctgaacc gattaccgtt 840721 ggcaccattc cgcaattcca gaaagggctc atggagcagc aggtatccgt tgagaagctg 840781 actgttgaag cgtgggcaga gaaatcgttc caaaagctgt ggcaggcgct gatcctgtca 840841 aaaacagtgc cgaacgcgcg tgtggcaaga ctcattcttg aggatttagt ggaggccaac 840901 aaagacttct ggcctgagct tgatcaaagc ccaacccgca tatcataaat gaaattcccc 840961 cattttcgaa tctgtaattg tatataatag aaagaaaatg gggggatctg atatgcagct 841021 cgaagaactg atcaatcagc actacagcaa attgaatgac aacgattttc atattttaaa 841081 atatatattg aatcataagc acacatgcta tcaccttgga atcgacgcgc tggccaaagc 841141 ttgcagtgta tcgcgttcct caattttacg gcttgcccaa aagctcggtt tcagcggtta 841201 cagtgaattt cgcgtctttt taaagtggga agatcagccg gaagaaggcg agagtatgag 841261 ttttgaaaag ctgcttgatg atattgaagc aaatttgaag tttttacgga caaaggacat 841321 gacggacatg tgccagctga ttgatgcagc tgaccgcatt ttcgtctacg gttctggaaa 841381 tgcgcaaaag atatgcgccc gcgacctgca aagaatgttt attccgcgcc atcgctatct 841441 tattttgatt gaagacacaa atgaatttaa tttgatgcgc gatgatttta aagtgaacga 841501 tctgtttatc atcatttctc tttccggaga aacaccggag ctgattcctc aggcaagaat 841561 gctttctgca aagggtattc cctttatttc cattacgaat ttaaaaaaca atgtcctcgc 841621 ccagctgact ccgcataatc tttatgcgac aagcaaacct gtgacattaa gcgatagaac 841681 ggaaattgtc gcttttgcac cgttttttct cgttggcgaa gcattgttcc gcgcatatgt 841741 tgattacaaa gaggcagaaa aaaatgacaa tgagtagcag ggggttctgg tatgatgcaa 841801 aaaattcagc gctttggaag cgcgatgttt gtgcctgttt tattattcgc gttcgccggc 841861 attatcgtcg gtatcagcac gctctttaaa aataaaaccc tcatgggacc gctcgccgat 841921 cctgacggtt tttggtatca gtgctggtat atcattgagc agggcggctg gactgttttt 841981 aaccaaatgc cgctcttatt cgccattggc atcccggttg ctttggcgaa gaaagctcag 842041 gcacgcgcct gtttggaagc gcttactgtc tacctgacat tcaactattt tgtcagcgcg 842101 atattgacgg tatggggagg agcatttggc gtcgacatga atcaagaggt cggcggaacg 842161 agcgggttaa cgatgattgc gggcataaaa acgctcgata ccaacatcat cggagccatc 842221 tttatttctt cgattgtcgt ctttttgcat aatcgctatt ttgataaaaa actgcccgat 842281 tttctcggca tctttcaagg ctcaacatat atcgtgatga tttccttctt tattatgatc 842341 ccaattgcgt tggctgtgtc ttatatttgg ccgatggttc aatcgggaat cggctcgctt 842401 caaagcttcc tggttgcttc tggggcggtg ggcgtttgga tatacacgtt tttggaacgg 842461 attttaattc cgaccggcct tcatcacttt atttacacgc cgtttattta tggcccggct 842521 gtagcggaag gcgggatcgt cacgtattgg gcacagcatc tcggcgaata ttcgcaaagc 842581 gccaaaccgc tgaaggagct ctttccgcaa ggcggattcg cgcttcacgg caactcgaaa 842641 atcttcggta ttccgggtat cgccctggct ttttatgtga cagccaaaaa ggaaaagaaa 842701 aaactcgtcg cagggctgct gattcctgtc acactgacag cgattgtcgc cggtattaca 842761 gagccgattg agtttacgtt cttattcatt tcacctttct tatttgcggt tcacgccgtg 842821 cttgccgcca caatgtcgac agttatgtat atggccggcg tcgtcggaaa tatgggaggc 842881 ggactgattg aggcggtaac cttgaactgg attccgctct ttggcagcca cggtatgaca 842941 tatgtgtatc aaattttgat cgggctctcg tttacagcaa tttatttttt cgtcttcaga 843001 tttttaatcc tcaaattcaa tatcgctaca ccaggacggg aaaaggatga acagcaggaa 843061 acaaagctat attcgaaaaa ggaatacaga gaacgaaaaa acaaggatga aacggcctcc 843121 gctgctgaaa cggctgatga caccgctttt ctgtatattg aagcgctggg cggaaaagac 843181 aacatcactg aagtcacaaa ctgcgccacc cgcctcagag tcagtgtcaa ggatgaaaca 843241 aaggttgaac ccgacagcgt attccgcgcg cttggcgcac acggcgttgt caggaacggg 843301 aaggcgtttc aggtaattat cggattaagc gtgccgcaga tgcgggagcg tgtggaaaaa 843361 atattgaatc aataaagact gccctccttt tcgggagggt tttcgtttgc cgtcaaaaag 843421 accgccatag taaagtaaag aaagagacaa tcgagtaaaa aggggtttgg aggcttttac 843481 atgcaaaagg ctttgtcgtt tttaaaacca tattcattgc tggcgggaat tgctctgatt 843541 cttatgctga cggagcttgc agttgaactg atgcagcctt tattgattgc aaaaatcatc 843601 gacgatggga tattgaagca agatctgcgg catgtatgga tatggggcac ggtcatgatc 843661 gggctgaccg tgttatcctt tgcggcgggg atgctgaatt ccttttatgc cgcccatgtc 843721 agccaaagct tttcctatga tacgagaaaa gggctttttc aaaaaatcca gtccttctcc 843781 tattccacat ttggacagtt ttcgtcctct tcttatatta caaggctgac aaacgacgtc 843841 acacaggttc aaaatatgat ttttatgagt ttgcggttta tgctgcgggc tcccttaatg 843901 attgcaggcg gcattgtgct gtcgcttgcc gttaatgtga aactcgggtt ttttctgctt 843961 gtgaccattc cgatcctgat cttgtttttg ctatgggtat taaggaaagg cggggcactg 844021 ttccgctcag tgcagaaaag gctggatcaa gtgaacacca tcatgcagga aaatttaatt 844081 gcaatcaagc tgatcaaagc gctgcttcgc ggcagccacg aagtcaaacg atttatcaaa 844141 gccaacacaa ggctgatgga aaaaacggtt tcggcctttc agcttgtgga attcacgatg 844201 cctgtactga tgctgctgat gaatctctgc atccttttga ttttgtgggc ggggtcctac 844261 agtattacga gcggaagcac tcaggttggc gatgttgttg cgataattaa ctacgcaaca 844321 cgaattacag gcgcgctttc gatgtttccg tttttgatta tgattttcac ccgggcgaag 844381 gcttcagggg atagaatcgg tgaggtgctt gaaacagaag gcgacgagcg ggaggaaggc 844441 accatatctg atcgtttgtc aggacggatt gagtttcagc atgtatcctt tcgctatcct 844501 gaaatggaca gagaagcgct caggaatgtc tcattttccg caaagccaag agaaacgatc 844561 gcgattctcg gtgcgacggg ctcgggcaag tccacgcttt ttcagctcat tccgcggctt 844621 tatcagccgg attcaggccg catttacata gatgaaaagc cggttcaaga tattccggct 844681 gaagggctgc gcaggcaaat tggatatgta ccgcaggaag tcctcttgtt ttccggcaca 844741 atcaaagaaa acatcgcttg gggcaaagaa aatgcttcac tagatgaaat aatggatgcg 844801 gcaaaacttg cgcaaattca tgaaacgatt ttaaagctcc caaatggata tgacactgtt 844861 ttggggcaaa gaggcgtcaa cctgtccggc ggccaaaagc agcggatttc cattgcgcgg 844921 gcgctgattc gaaaaccggc tatccttcta ttagatgaca gcacaagcgc gcttgatctg 844981 caaacggagg cgaagctgct tgaagcaatc agcacatacc attgcacaac tttgatcatt 845041 acacaaaaaa taaccacggc gatgaaagct gatcagattt tgctgcttga ggacggcgaa 845101 ctgattgaaa aaggcactca cagtgagctg ctttctgaat ctcagttata caagcgcatt 845161 tacgagtcac aattcggaag ggaggggagc gagtcatgct aaaagacatc cgcaagcctt 845221 tccaatatcc caaactgcca attgacaaaa aagaaggcgc gaaaaagcgg gcgaaagcaa 845281 aggatacaaa gggcacactg agacgaatct ggtcttactt ggctgaaaga aaaggactgc 845341 tcatacttgt catgctaatg gttgtcatca gcgccatatt cggactcctt ggtccctttg 845401 tgatcggaaa ggccatcgac cattttatcg tcgggaaaac ggtcagcggc ttgattcctg 845461 ttttgcttct tctgctcgct atctatatca ttcagtccct gtcgctttgg tttcaaaact 845521 attggatgat tacgatctcg cagggcacgg ttttcagaat gagaagcgaa ttgttcaccc 845581 atctgcatga gctgccgatt ccattttttg ataaacagcg gcacggcgag ctgatgagcc 845641 gggtgacgaa tgacatcgaa aatgtcagtt ctaccttaaa cacgtcagtc attcaaattt 845701 tgtcaagtgt gatcaccttt gtcgggacga ttgcggtgat gctgtacatg agcccgctcc 845761 ttactttgat tacgctgacc attattccgg tgatggcagc gagcctgaaa tggatcacca 845821 accgaacggg aaagctgttt aaagaacagc agaaaaacct tggtgatctg aatgggtata 845881 ttgaggaatc tgtttcaggc gcaaaggtca tcaaagcata ttcacgtgag aagcagatta 845941 ctgctgaatt cctcgaaaaa aacgctgcac tcaagacgtc gggcttttgg gcgcagacga 846001 tttccgggtt tattccgaag gtcatgaact ctttgaataa cttaagcttt acaatgattg 846061 cggcaatcgg cggtttgttt gcgctgaaag gctggatctc gatcggctcc atcgttgtct 846121 ttgccgagta ttcaagacaa tttacacgcc ctttaaacga tctggccaac cagtttaata 846181 cgatgctgtc cgcaatcgcc ggcgctgaac gggtgtttga cgtgcttgat gaaaaagaag 846241 agcgcgagga tgaaaagaac gccgtgcatc agcccatcca aacaggcagc attgaattcc 846301 gggatgtgtc cttcggttac gataaagggc agcagacact gaagcattta cagtttaccg 846361 tgcctgcggg gcagtccatc gcgtttgtag gaccgacggg ggcggggaag acaaccgtca 846421 ctaaccttct cgcccgtttt tacgagccta acgatggaaa aattttaatc gatggtacag 846481 atattaaaac ccttactaga gcaagcctaa gaaaaaacat ggggtttgtt cttcaggatt 846541 ctttcttatt tcagggaacg atcagagaaa acattcgcta cggcaggctt gatgcttctg 846601 atcaggaagt cgaagccgct gcaaaaacag cgaatgccca tagttttatt gaaaggctgc 846661 caaaagggta tgacaccgta ctgacgcaaa acggttcggg catcagtcaa gggcagaagc 846721 agttgatttc tatagcgagg gcggtgcttg ccgatccggt tcttctcatt ttggatgaag 846781 cgacaagcaa cattgatacc gttacagaag tcaacattca agaagcgctc gcccgtttaa 846841 tggaaggaag aacaagcgtc atcattgccc acaggctgaa caccattcaa agagcggacc 846901 agattgtggt gctaaaaaac ggtgaaatga ttgaaaaagg cagccatgac gagctgattc 846961 ggcaaaaagg attttacagt gacttatatg aaagccaatt tgagaaatag acctttgtcc 847021 tgcacagagg tctttttttg ttacagtttt atagtacttt tatttcattt tcgtaaaatg 847081 taacaaaatt acttgacgta aacaagttat gtatatatac tagcttacat taagtaagtg 847141 ataacattta tcaaggagga taaaatgaat aaatcatttg aaattggcac attactttta 847201 agagttatta caggtattat cttttttgtt cacggtttat caaagtttca gggaatggag 847261 ggcaccatcc aatttttcgg cagcataggc cttccaagct ttatggcgta tgtcatcgca 847321 gcgattgaac tgattggcgg agtgcttgtc ttcttcggat tggctacacg tattgtcggt 847381 gtactgttcg ctcttacact gatcggcgcc atcatcactg ttaagctgaa agcgccattc 847441 atgggcaatg cagaatttga ttaccttctg cttttgacat ccattcacct ggcgcttact 847501 ggaagtcgat tcctggcgct ggacccattt gtgtttaaag gaaaaaagaa cggaaacgtt 847561 tcagcataag aaaagaggca tgcagcatga ccagcattca tgaggataca cacattggct 847621 atgccaaact cacaattcgc agtctggagc gttcgcttca gttctactgt aacgtcatcg 847681 gttttcaagt cttaaaaaag acggaccgcc aagcggaatt aacggctgac gggaaacgcg 847741 tactgcttat tcttgaagaa aatccgagcg ctgtcgtctt gcctgaacgg tctgtgacag 847801 gcctttatca ctttgcgatt cttcttccgg acaggaaaga acttgggatc gcgctcgccc 847861 gcctgattga acacggcatt gctatcggac atggagacca tgctgtcagc gaagcgctct 847921 acctgtctga tcctgacgga aacggcattg aaatgtacgc tgaccgcccc cgcagcacgt 847981 ggcagcgtga tcgggaagga aactacgtca tgacgacaac cgctgttgac attgagggcc 848041 ttctggaaga ggcaggagat gagcggaaaa catcgcttcc gaacgataca atcatcggac 848101 acattcatct gcatgtcagt gatttgaaag aagcaaaggc gttttataca gatgtactgg 848161 gctttgacat tgtcggaaac tatgcgggca tgtccgccct cttcgtttca gccggggggt 848221 accaccatca tatcggctta aacatttggg cgggaagaaa tgcgccgcct aaaccgacaa 848281 atgccagcgg actagattat tatactgttg tcctgcccca ccaagaggag ctggatttgg 848341 tggcaaaccg agtcaaacat gccgggtatt cgattgaaga gacggaaaac agctttcgtg 848401 tgaaagaccc tgtttccggc gcctatatta catttgtgat ttaactgcaa tccccttgcc 848461 gaaataacgg cagggggatt ttttattttt gtccgccttg ttatgatgag agaaccaact 848521 tgttaggagg cgtttacatg gaactcaacc accttgtgac gggcaaaata gcattaaatc 848581 aatatgtgca tcgcttagag caaaaggatg tttcatttta cgtccactac tggggagcga 848641 tgacgaacca ctataacaca ctgcttcata agcattcctt ttatgaaatt tgttacgtgg 848701 taagaggtga aggatattac cttgaaggcg atcgtacata tccgcttcgt gaacagacga 848761 tttttttgtc aaagccggag catttgcacc aaatcaaaag tgaaacaggg ctgttccttt 848821 tttacgtcgc tttcgagctg agcgaggatc agtcaagcgc cgaatggatc aaagtgatgg 848881 aagaagtgaa acaaagcccc tttatcacaa tgcaattgaa agatggcgaa ccgccgggcc 848941 tgctttggaa aacgttaatg ctgcaagcag cgcaacctgt caatgctttt gacaaagaga 849001 tcctatctca tttgtcgcat gcattgatcc tgtcattaat ccaaaccttt ctcccgtacg 849061 cccaacgccc gaaacaaaag cagcccattc acacatcttc tgctttgctg acagaggtga 849121 aactgcacat aaaagacaat ctgtcacagc cgttaaagct gacggatgtc gctagccact 849181 ttcatatctc agggaggcat ttatcacgtt tatttgcagc agaactgggc gtcagctact 849241 cagaatttgt ccaaaatgaa aaaataaaca aagctgccga actgctgaaa tcaacgaatt 849301 tgtcgattaa agaaatagcg gaagaaatcg gtttctcagt acattatttc actcgcgtct 849361 tttccgctaa aatcggcagc tctccagggc ttttccgctc cctttataaa gactcaaaaa 849421 tgaccgcatt tcaaatcaat aaaccttttc aaaaaatcga acaggccaag ccgcacgaat 849481 aagatgtcct gaaatgacaa aacaatgtct tcatatgata aagacgcgag aaatctcgtt 849541 gtcttataat ctttttagaa agcggttaca acaaggggta ttgctgaagg agggatgcat 849601 tggcttatgc ttggtgtcgg gtgctctgcc attcttgaaa gaaggggaag aaagccgtga 849661 gtacaaaaaa gaaagaggct gtaataggaa aagaaagctt agctcataaa gggcttttac 849721 gaacgattac attggtatct acattcggcg gcctgttgtt cggttatgat acgggtgtca 849781 ttaatggggc acttcctttt atggcaactg caggtcagct gaatcttaca cctgttacag 849841 aaggactggt tgcgagttcc ctgcttctcg gggcagcctt cggggcgatg tttggaggac 849901 gtctgtccga tcggcacggc cgccgaaaaa cgatccttta tttagcctta ctcttcatcg 849961 cagccacact tggctgtacc ttttcaccaa acgcgtccgt gatgattgcc tttcgttttc 850021 tgcttggact ggcggttggc tgcgcttctg taacggttcc aaccttttta gcggaaattt 850081 cgccggcaga acgcagggga cgaatcgtga cacaaaatga actgatgatc gtaattggcc 850141 agcttctggc atacaccttt aacgccatta ttggcagcac aatgggggag agcgcaaatg 850201 tatggcggta tatgctggtc atcgcgacac ttccggctgt tgtgttatgg ttcggaatgc 850261 tcatcgtgcc tgaaagcccg cgctggctgg cagctaaagg cagaatgggt gacgccctgc 850321 gggtgcttcg gcaaatccgt gaagacagtc aggcacagca ggaaataaaa gaaatcaaac 850381 atgcgattga gggcacagca aaaaaggccg gctttcatga ttttcaagag ccgtggataa 850441 ggcgcattct attcattggg attggaatcg ccatcgtaca gcaaattacc ggtgtcaatt 850501 cgattatgta ctatgggaca gaaattctga gagaagccgg ttttcaaaca gaagctgcat 850561 taatcggcaa tattgcaaac ggtgttattt cagttattgc ggtcattttt gggatatggc 850621 ttctcggcaa agtccgtcgc cggcccatgc tgatcatcgg acagattggc acgatgacag 850681 cccttctgct gatcgggatt ttatccattg tccttgaagg aacacccgcc ctgccgtatg 850741 ttgtgctgag tttgaccatt ttgtttcttg cgtttcagca gactgccatt tctacggtga 850801 cgtggctgat gctctcggaa atctttccta tgcatgtgcg ggggcttggc atggggatca 850861 gcaccttctg cttgtggaca gctaactttc tcattggatt cacctttccc attttgctca 850921 atcatattgg gatgtcggcg acatttttta tctttgtcgc tatgaatatc ctagcgattc 850981 tatttgtgaa aaaatatgtg cctgagacaa aagggcggtc acttgaacag cttgagcatt 851041 cctttcgcca gtatggccgc cgcgctgatc aggaaatcca aaatcaaaca actcacttat 851101 cgtaacctga gataccagga ggaatctatc aatgaaacta tcttatgtaa cagacagcct 851161 agggcatttg ccttttgaag acatgctcaa ttttgccgca aagcttggga tcgatacact 851221 tgaaatgaca accgggggct ggtcgccggc acctcacttg aatcttgatg aattgctgca 851281 aagcagcgaa aaaagaaaag aattttcaca agcgctggaa aagcggaaca tgacactttg 851341 cgcattaaac tgctcgggga accctttaga tccgggtgaa ttgggcaaat cgcacagaga 851401 cataactgac aaaacgatgg agctggctgg attattaggc gtcaaaaaag tgatcatgat 851461 gagcggtttg ccagccggcg gcccggacga caaagtgccg aactggatca catacacagt 851521 aagctggcct cccgttttaa aagatatcct caactatcaa tgggaagacg ttgcgatccc 851581 atattggaag aagcttgtca aaaaagcgga ggcctgcggc gtggggaaaa tagcgcttga 851641 gaacttcagc tctcaattag tctataatcc tgagactctc tttcggctca gaaatgcagt 851701 cggcccgatg gtcggtttga atcttgaccc gagccatttg ttatggatgg gcgcagaccc 851761 gatcatcgca gcaagggagc tcggctcagc cattcaccat gtccatggga aagatgtcag 851821 aattgaaaga tatttatcgg cggtcaacgg acttttagaa acaaaagaag tgacagatcc 851881 tgcaaaccgg gcgtggaatt acgtagctgt cggctgtgga caggatttac agtggtggaa 851941 ggaatttttt tcagttgtaa aaatgatggg atatgaaggt gaggtttctt tagaaatgga 852001 ggatctgacg atgtcacctg aagcgggcat ccgtacttct gtagaagctt taaaacaaac 852061 catcagccaa taggaggttt tcatgatgct aaatggagaa agaatcatct ctaagccgct 852121 tcgctgggca atggtaggcg gcgggcggct cagccaggtt ggatataaac atcgtattgg 852181 agcgctgaga gacaatactg cttttcaatt aactgctggc gcttttgata tcgatgccga 852241 aagaggaaaa gatttcgggg tgaaccttgg agtggatgcg gaacgctgtt atcccaacta 852301 tcaaaccatg tttgccgagg aagcgaaaag acaggatggc atagaggtag tatcgattgc 852361 cactccgaac ggcactcatt atgagatttg taaggcggcg cttgaagcag gagtgcatgt 852421 catctgtgaa aaaccgctgt tcttcacttc agcagagggg caggaaatca aagcgctcgc 852481 agagaaaaaa gggaaaattg tcggcgtgac gtacggtttt tcaggcaatc aaatgcttct 852541 tcaaatgcgt gcgatgattg aacaaggaat gatcggcgat attcgcgtgg ttgacttgca 852601 gtacacacac ggtttttgtg caacagatga aggtgaaaag ataagcgctg cacagaaatg 852661 gcgtgtcgac cctgcgatcg ccgggccaag ctttgtgctg ggcgatttat ctacccacac 852721 gtattatatg tcacagctta ttatgccaaa gatgaaaatt aaggagctgc tgtgtgaccg 852781 acagagcttc gtcggcagcc gcgcaccgct agaggataat gcccatgtgc tgatgcatta 852841 tgaaaatgga gcggtcggaa cgatgtggac atcgtcaatc aatgccggat gtatggatgg 852901 ccatagaatc cggattgtcg gctcaaaggc aagcattgag tggtgggaca gcaagccaaa 852961 tgaactgacg tatgaagtgc agggagagcc gggccagaca ctcgttcgcg gcatgccgta 853021 tttagatgat gtttgcaacg ccgatgaacg actgggcgcc ttacacagcg aagggctgtc 853081 cgaagcatgg gccaatattt atcttaaatt tgccattgcg atagacgcca aaaaccgtga 853141 agatgaagaa atcttgaaca acttggttta tcctgacatt gatgcaggga tcgagggcat 853201 tcgctggatt gagaactgcg tgcgctcggc aaaccaaggg tcagtttggg ttgaatttaa 853261 ataaatgagg gaatgcgccg catatgacat aaagttcata tgcggttttt attttccaga 853321 aactcctgtc aaaaatgccc tgaggcaggt atgataagaa gggaattggg tatcgggagt 853381 gatgagcgtg aaagctcttt tttttacgag aatgttcacc ttgatggtga gctgtttaat 853441 gtatctgtcc attgtgaaag aggataactg gtttggatat gtatttatag cagcaggtgc 853501 tgccatgtat gcagccaatc atgttttgct gacaaaagag acaaatgcca tctggttctg 853561 cctgattgat attgcaatcg gcttttcgtt cggatttatc tttcccggca caggtttgtt 853621 cattattatg ctttgtccgg ttgcggtcgc cttttttctg cgggggtttc ctaaaagaac 853681 agcatggtct gtcttatgtc tttcctctat tttatttttg accgtcctca tccgtacata 853741 tgcgatgttc ggcaatgaat ttgtcattga tcatttgact agcatgacat tcgttgtctt 853801 ctgcggtgtc gtgggcaaat taatccgcaa gctgttggat gcgcaggata cggcaaaaca 853861 gcagtttcag gaactgacgg agtcccatct ggcgctgtct gctgcacatc aggagctcca 853921 tttatatgcg aagcaggttg aagagctgac tgccatttac gagcggaaca gaatggcgcg 853981 tgaaatccat gatacagtgg ggcataaaat gacggccctt ctcgtccagc tgcagctttt 854041 gcgtgaatgg caaaaaagag acagccaaaa agcggatgag acagtaggtg tctgtgaaac 854101 acttgcccgt gaagcgcttg atgatgtccg cttatcagta cgcactctgc aaactgaaaa 854161 cgatccttcg ctaatcgaat cgctgaaaca gctgacagag gacttttgca aaaatgcagg 854221 agtcacaaca gaatttgcgg tcagcggtga tcctgcaatc atcccgctgt ctctccatcc 854281 gaccctgatc agaacggtgc aggaagcact gaccaatgcc aaacggcacg gcggcgccgc 854341 agcctgttcg atacagcttg cctgcacaac ggacagcatc agccttgtca ttaaggatga 854401 cggcaaaggc aatcctgagg cagcacttgg ttttggtctc ttgaatatga aaaagcgggc 854461 agcggagcat ggcggaatga tccgctttga aagcgaacgg gatcaaggat ttactgtaaa 854521 tgcagaattt tcacttgcca ataaaaaatg gagcttcggg cccgtgcagc aaaaggagag 854581 tttatcatga ttaagatcat cattaccgac gatcaggata tcgtcagaga agggctggca 854641 tccctgctcc agctccgaga agagctcgat gtgatcgcaa cggcgcgaaa cggacaggaa 854701 gccttcgaaa aggcgaaaga gctggagccg gatatcgtgt taatggacat ccgcatgccg 854761 gtttccaacg gggtggaggg aacaaaatta atcacaagct cgctgccaag cgtaaaggtt 854821 ttgatgctga caacctttaa ggattcagcg ctgattgctg aagcgcttga agagggagca 854881 agcgggtatc tgctgaagga tatgtctgca gatacgattg taaaagcagt gatgactgtt 854941 cattctggcg gaatggtgct tccgccggaa ttgactgccc aaatgctgaa tgaatggaag 855001 cgtgaaaaac agctgaaagg aataaatgag atagaaaaac ctaacgagct gctcgacctg 855061 accgagcgcg aaatcgaagt tctggctgag ctgggatacg ggctgaataa caaagaaatt 855121 gccgaaaagc tttacattac agaaggcaca gtcaaaaacc acgtttcaaa tattatcagc 855181 aagctggctg tcagggacag aacccaagcc gccatttact cggtcagata tggtgtatct 855241 gtcttttgac atatgacgtt ttgcatatac gcttctctga aaaggccttt tacaggcctt 855301 tttttcatgc cctatgttct atctgccgct acatgccgca cgcctttctt tcttctacaa 855361 tggcaatgga tcaaaaaaag gagtgagacg acgtgctgca agcagaaaac atcaaaaagg 855421 catacggaaa aaaaacaatc gtgaaaggca tttctttttc cctcaaaaag ggggagtcgt 855481 tcggtctgct cgggcctaac ggtgcgggga aatccacaac catctcgatg atttccggcc 855541 ttgtgccgca tgacagcggg aacatcacgg tgggcggcta tgttatcgga aaagaaacgg 855601 ccaaagcgaa acaaaaaatc ggcattgttc cgcaggaaat tgcattatat ccgacgctga 855661 cggctcatga gaatcttatg ttttggggga aaatgtacgg acttacgcac ggtgaggcca 855721 aaaaaagagc ggctgaggtc cttgaatatg tcggtctgac tgagcgggct aaagataaga 855781 ttgaaacatt ttccgggggg atgaaacgaa gaatcaacat cggtgcggct ttaatgcata 855841 agcccgagct gctgattatg gatgaaccga ctgtcggtat tgaccctcaa tcgagaaatc 855901 acattttaga aacggtcaaa cagctcaacg aaacgggcat gacggtgatc tatacgagtc 855961 attacatgga agaagttgag tttttatgcg accggatcgg gataattgat cagggggaaa 856021 tgattgcgat tggcacaaaa actgatttgt gcagccgcct tgggggcgat accatcattc 856081 agctcacggt cagcgggatc aatgaagcgt ttcttgtggc gatccgatct ctggcccatg 856141 tgaatgatgt aacagtacat gaattagagc tcaaaattga catttctgcg gctcatcatg 856201 agaaagtcgt cacaagcctg cttgctgaag ccactgctca tcatataaac ctgctgtctc 856261 ttcaggtgca ggaaccgaat ctggagcgcc tgtttctgaa tctgaccggc cgcacgttgc 856321 gggattgagg agggacggca atgaaaaaaa gcatatggat cgcatggaaa gatgtgaaaa 856381 tcagaatcac ggacagaaaa gggtttatga tgcttatcct aatgccgctc atcctaacct 856441 gtattttagg cgcagcgctc ggatcagttg ttgacggagg cagccggatt gatgatatca 856501 aagtcggcta cattcaatca gaccagtcag atacagcaaa catgtttaca aaagatgttc 856561 tcaaaaaaat gaagtcgata aaggtcacaa aagtcggcag caaagacaag atgaaaaaac 856621 tgattgatga aaagaaaatc gatgtaggca tcgttatccc gaaccattgg gaagccggca 856681 aaacctcagc tgttgttaat gccgctcctg atcaaacatt gaaaagttcc atcattgaaa 856741 cagctgcaag ctcatttata gagcaatata aagcggtaaa ggaagccgcg tcaggctcaa 856801 tggactacat cagtaaaacg gaagctgtaa agcaaggaaa acttgaccct gcacagtttg 856861 cagaaaagct ggcaaagacg ctagaaaaag aaacaggtga caagcttact attgcggaaa 856921 aatctgtcgg cagcaaagcc gttaccagtt ttcaatacta ttcggcggca atgctttgca 856981 tgtttatgct gtttcatatc acagtcgggg cgaaatcatt tttacaggaa aaggatacgg 857041 agacgcttgc cagaatgctg atgacgcctg cgcaaaaatc cgtcattctc ttcggaaaat 857101 ggcttgggac gtatctgttt gccatcatac aatttttcat atttctgatc gtcacaatca 857161 acgtatttgg tgtggactgg ggcggtaatc tgctgttagt gagtgtactc gggctttctt 857221 acgccgcagc tgtatctggt atttcaatgc tgcttgcgtc gtgcatcagc gatatgaaaa 857281 ctgcagatgc gataggcggc ttcggcattc aattgcttgc ggttctcggc gggtccatgc 857341 tgccgctgta ccaatttccg gacgtcttgc agtctgtatc caaagcggtg ccaaatcgct 857401 gggcgcttga cggctttctt tctttaatgg aagggggagg ctgggctgac cttcaaaagc 857461 ctgtgcttct ttttgcggcg atcggctttt gttcacttgt aattggtatc agacggcttc 857521 atacaagata aggaggtaca aaaggtgaaa aaaattctag ccatttgcgg cattgagctt 857581 tctctcattt ttaagaagcc acagaactat ttgatcatgt ttgctgcccc gcttttgctt 857641 acctttgtat ttgggagtat gctcagcggc aatgatgata aggtgcggct tgcaatcgtt 857701 gatcaggacg atacgattct ctcacagcat tatattcggc agctgaaggc acacgatgat 857761 atgtatgtat tcgaaaacat gtctgaaagc aaagcgtcag aaaagctgaa acaaaagaaa 857821 attgccggga tcatcgtcat ttcccgctcg ttccagacac agctggaaaa aggcaaacat 857881 cctgagctga ttttccgtca cggccctgag ctgtcggaag cgccgatggt caaacaatat 857941 gcagaaagcg cattggcaac gctcaatatt caggtgaccg cggcaaaaac ggcatctcag 858001 acagcgggag agaactggaa ggcggcgtat aaaacggttt tcgccaaaaa acatgaagat 858061 atagttccgg ctgtaacacg acagacgctc agtgataaaa aagagggtgc ggaagcaagt 858121 gacacagcct ccagagcagc agggttttcc atcctgtttg tcatgctgac catgatggga 858181 gcggctggaa ccattttaga agcaagaaaa aacggcgtat ggtccagatt gcttacagcc 858241 tctgtcagcc gagccgaaat cggtgctggg tatgtgctgt ccttctttgt cattggctgg 858301 attcaatttg gaatattgct tctttccacc cattggctgt ttggcatcaa ctgggggaat 858361 ccggctgcag ttattgtatt agtgtcactt tttctattga ccgttgtcgg cattggattg 858421 atgattgcgg ccaacgtcag aacgccagaa cagcagcttg cgttcggcaa cttgtttgtc 858481 atcgcaacat gtatggtgag cgggatgtat tggccgatcg acattgaacc gaaatttatg 858541 caatccatcg ctgaatttct tccgcaaaag tgggcgatga gcgggttgac agagattatc 858601 gctaacggtg cccgcgtcac agatattctc ggaatctgcg gcattttgct tgcatttgct 858661 gcgatcactt tcgcagcggg gctgaaagcg ctccgagcct aaaaaacatc tgccgtttag 858721 gcagatgttt ttttgcatgt gggtacattc gtatgggtgc agcctgaact gcggttaatc 858781 cttatctatc atagctaaaa ttgattccag ccaagaaacg taatttttct cccgctccag 858841 cgctttcgtt agcacaagat agtggccgaa gtccggtgaa gaaaatgaca tcggctctgc 858901 tgaagccata agcttttcat agcttccctg taagtcagaa agcttggcct ggcgtttttg 858961 cagctggtct ttgaacaaat cagaagcctc ctggcgcgat agacaagaaa tgaaataagc 859021 cttcagcata aattcatcct tcaccgtctc gggtatcggc tggtggcgga tcagccagtc 859081 atgcagctcc tgctttccgc tgtctgtcag ggtgtacatc tttttctcca gctttgtgcc 859141 ctgaatcgtt gtccggaacg tgataaatcc ttcatccgtc agctttttga gctcagggta 859201 aatctggctg tgcttggcgc tccaaaactg gccgagctcc tctttaaaat aactcgtaat 859261 atcgtatcca ctcaattcgc cttttcgcaa aagccctaat atggcgtatt ttaatactct 859321 catgctatcc tccgtgtctg gctgtttcgc aaaacagatg agccggtgct caactgtgat 859381 tctaactgcc tattcccctt attatagaaa agggaggaag ggaacacaac cgggctcttt 859441 ggaaatgaag ataaaaggtt tgtcagaagg tatccgattt atctccgtca atataaaaga 859501 gatttaaatt taattttcag aaaaaatagt aacgatattg attttttata tataatagga 859561 aattggtggt atgaaaattt tttgggggaa taaacgtgaa aaaagtactt atggcattca 859621 ttatttgttt atcgctgatt ctatctgttt tagccgctcc gccgtctggc gcaaaagctg 859681 agtcagtaca taatcctgtc gttcttgttc atggaataag tggtgcatca tacaactttt 859741 tcgctattaa aaactactta atttctcaag gctggcaaag caacaaactg tacgcaattg 859801 atttttatga taaaacagga aacaacctaa ataacggccc gcagcttgct tcatatgttg 859861 accgtgtttt aaaagagact ggggcaaaaa aagtagatat tgtggctcat agtatgggag 859921 gcgccaatac gctgtactat attaaatatt taggcggggg caataagatt caaaatgtcg 859981 taacgcttgg aggggctaat ggtttagtgt catcaaccgc gctgccgggc acagacccta 860041 atcaaaagat cctctataca tctatttaca gtctcaatga tcaaattgtc atcaatagct 860101 tgtctcggtt acaaggagcg cgaaacatcc agctttatgg catcggtcat attggcttgc 860161 tttctaatag ccaagtgaac ggctatatca aagaagggct gaatggcgga ggcctcaata 860221 caaattaata tcttcaaaaa acaacctgct gtctccgtta cagtgggttt tttcgtctga 860281 gaaagccata gggtcttatg accttagtct atcatgcata cgtcaattta tgacatcagg 860341 cactttttca aatagagcgg acatgttaag gtacaaccat cgatttctat caatttgaaa 860401 taaaaggagc gctgttatgc aaattaaaga aatttttatg atccgctgca tttcgtgctt 860461 aagtgtcgtc ttgctccata tcatttcaat ggtcctgatg cttcaggcag aagctcttgc 860521 agatatttct cacactgttg attctttccg cacactcctg atgttcagca cgcccgcttt 860581 tattttcatc tctgaatttt tactggcccg ttcttatcct gatggggtgc ctgacggttt 860641 tttaaagaag cggggaaaag tgatttttgt tcctttttta tttatcgcag ccatcgatgc 860701 gctgctgatg accagtgcga tggggggaga ggtaaccttt ctcgcgtttg tgcaaaaata 860761 tctggcgaac gtattcttag gaaactttat cggatacttc attctcgtca tctttcaatt 860821 ttacatgctg catatgatgt ttcatgagta tttgaaaaaa gcatcgccga aatgggtgct 860881 gtctatctca tttgtggtga cagccgctta tttaggctat ttctccgcag ccagcccggc 860941 tcctgcttct gaagagggag gggcatttcc gttcttctgg gttccgttcg caggctggct 861001 tttctacttt tgtctagcct actattgcgg aaaagaatac aagcgttttt tagcgctgct 861061 gaaccaatac cgctgggtgg tgtacggcgc cgcaattgct tctggggcgc tggttgtcac 861121 tgtttcttat gtcggtgaaa tcggcatgat cagctcgaag cggcctgata tcatgctgta 861181 ttcaacaagc atgattttcc tgtgttttca tttgttttcc aaaatgaagc atgtgccgaa 861241 aatcatgatg tttatcagca actattcctt ttcgatttat ctgcttcatg cctattttat 861301 gattataggc tacgtgttgc ttttgaatat gcccgaaatt cctgccgtac cggctgttct 861361 cctgttgttt gccgtgtgca cagccggccc gattatgacc tcatgggcgc tgaataagtt 861421 caaatacggg tatttatttg tggggaaaat ttatcagcca aaacagaaga aggtaacagt 861481 cgaagtgcgt gatcacgcag ggtgaaaaac aagcggcagg agggctcctg ccgcgtttct 861541 ttacttctca tccgcttgca gaactgtttt taaatatagt tttgcagact cagcaagtcc 861601 agatacatca gccttttctt catcgaaata cagggcgttt tgaatgatgc cgtcattcat 861661 attgaggaaa aacttggcga tagtcgcaag aggctgaacc ggctgaaact ctccctgatc 861721 gatccctttt tgcaatagcc ttgaaaacct ttccacaaaa agatcatacc ttttctccaa 861781 atactgccgc cgttcttcat tgcgccaagc tgtcactaaa tattcaaatt gcaccggcgc 861841 cagcgtatct gctacatctc gcaggccctc agtcagttca tccaaatagc tggaaatgga 861901 ggcccaaaca ctttggtgtt cagctgattt atcaagcttt cggagtcctt catccagccc 861961 tgtttcaata atgcggcgaa acatctcctc agtgcttgaa aaataaagat agacaccgcc 862021 ccggctgaaa cctgactctt ctacaacatc cttcatcgtc gttaattcga atccttttcg 862081 tttaaaaacc gttttggcag cctctaaaat ctctgcctgc cgtttatcct tgtgctcctt 862141 tgttactttt ggtgacaaga tatcgcctgc tttctgcaat tttcttacct ataagtgtaa 862201 tcaacccaat catgatcagc aagcagccac agacaagaaa agcaagtgat acaccgatcc 862261 attccgccag cacgcccccg cccgccatgc cgaggataga ggcgagggtt gtcgcactct 862321 gaatagcgcc gaacacccta ccgctgtaat cgacaggcac tgttgtttgc acgagaatct 862381 gaaatggaat atggacgagg ccgaaagccg cccccatgat gaaaaaagca aatataaaga 862441 gagtgatgcc ggcaattccc ataccgctta ggaatggcgc acctccagtt gctagtccaa 862501 gaagaagggt tccagctgag aaataaagca aataagaagt gattcgccgt ctgccggtaa 862561 tggccgctgt aaggagcatc ccggctccgc ttacggccat gcaccagcct gccagctcgg 862621 gcggagctcc tgaaaaggag cggataagaa taatcgcttg ggaatcacca atctgcaaaa 862681 caaagagaac gacacaagct gttagtaagc ctgttaatag aagcggcatc cgtttcaaaa 862741 actgaaggcc ttccttgata gaagtaagtg ctgctgtttt ttcttgaggt gtattggctt 862801 tttgtaaaaa agcatctctg ggaaggaaaa acaaaatgac agcggaaaga aagaaggcgc 862861 cggcgtttat ataaaaaaca gagtgtatcg agaaagcagc gatcagcgtg ccgccaaggg 862921 cagggccgaa gatttttgag ctgttatcaa tgatgctgct gacggaaacg gcctgctgaa 862981 tgtgtgcttc cggagccaat tccttaagct ttccgttttt agcaggtaaa aaaagtgaag 863041 aaaaacagct ctgaacggat agcaatacgt aaagctgcca aagctcactg acataaacgc 863101 agctgataac agtgagggca cggccgattt cagatagaaa catgatcgtt tttctgtcaa 863161 aacggtcggc aagcagaccc gatacaggtc cgagtacaat gacaggcaaa gcaaacgaca 863221 tcattaaaag cgacatatct aatggagaag catgaagctg aaaagcggct aatgttagca 863281 cggccaaaat gtgaagccag tctccaagtg aagaaatggt ttgcgaggct aacagtgtca 863341 tcagtccttt ttgattgcga aacaacggtt tttccatgat tcatcctcct gattattaaa 863401 atgacactag tgtcgttttt aattgtatgg gaaaaagaca caatatacaa tctttttctt 863461 gtaaaataaa ggagaagatt gaatagaagg gagaacattc atgacatcag tcaatctaag 863521 ctacccaata ggagaataca agccgaggga atccatatcg aaggagcaaa aagataaatg 863581 gattcaagta cttgaagaag tgccggcaaa attgaagcaa gctgtagagg tcatgacgga 863641 cagccagctt gacacaccgt accgggacgg tggatggacc gttcggcaag ttgttcatca 863701 tctggctgac agtcatatga acagctatat tcgttttaaa ttgagcttga cggaagagac 863761 accggctatc cgtccgtatg atgaaaaagc atggtcggag ctaaaagact cgaaaacggc 863821 agatccgagc ggctcactcg cgcttttgca ggagcttcac ggaagatgga cggctctgct 863881 ccgcaccctg acggatcagc aatttaagcg cggattttat caccctgata caaaggagat 863941 cattaccctg gagaacgcgc tcggcctgta tgtctggcac tcacatcacc atatcgctca 864001 tattacggag ctttccagac ggatggggtg gtcttaacgc ttttgccggc ggaaagccgg 864061 aatactgata gcagcaatca ccagaagtga gaccacagca gccgctgcat ataaatgatc 864121 atagccgctg gcgacactcg catgaatggc gtcgcttatc gcggttttga cttcaggaac 864181 gggaatgcgt tcgatttgtt cttgtaaaga agaaacttca gaactgtcga tctccggaat 864241 catctgcatc gccttttctg aatatccgct gtccgataag cggctgttga tctcatcacc 864301 tatttggtca aacccggctg tgataaaacc tgcataaaga gtaggcgcca aggtcagtcc 864361 aatttgcctt actaatgaaa gcgtgccaag agctgtaccc ttatttgttt ttgccgcttc 864421 tgatacaagg acgttcagcg gagcgcctaa cagaaagcca aaaccgatcc cagctgccac 864481 acttgcgatc acaaactccc atttttccgt gacccagagc ggaaataaag caaaccccgc 864541 acatgagatg attcccgaaa gaataacggt ttttacagga ccttttttgt cggtaagtgc 864601 tccgccaagc caagcgccga ttccggaagc caacgcaagc ggtgtcatcc aatagcctgc 864661 ttttgcggca gggacaccca aatactgttc gacatatgac gggataaaaa tgactgccgc 864721 caagagcccc ccggataaca aaccgatgat aagcgtgcgc tgaaacatat ggtttcgcag 864781 cagagaatac gccaaaatgg gatcgcctcc tcgcatttca actctctttt catacgagat 864841 aagcgctgca aaacagagta tgccaaaaat aatacatcca taaacctccg gattccccaa 864901 gctgtgtaag agatttgccc cgtcaagatt ggtcatgccg tacatcacag ctaaaatcga 864961 cagggacaaa aggaagattc cggccgcatc gaggcgctta gcctcaggtg cttttgtttc 865021 cgcgataaaa catgcgccga aaacaaccaa tagcacggca atcggcaaat taatcaaaaa 865081 tagccaatgc caagacccgg tccaatcaag cagaaagctt ccgatatttg gcccgagcac 865141 agcggccatc ccgttcattg cgccaagcag cccaagcgcc ttcccctgtt tttcctttgg 865201 aagggtcgcg agaatgtgag agctgccgat gatgaaaatc ccgccgcctc caagcgcctg 865261 aatcagccgc gatatcagaa agagcgggaa gctttggctc aaagcaacaa gcaaagaacc 865321 aagtccgaac aggcaaacct caatgagaaa gagttttttt ctgccgtagc ggtcggaaag 865381 ttttccgacg attggcacac tgacgctaag accgagcgta taaagggtaa tgccccatga 865441 tccccaggaa ggggaaacgg aaaacgactc gtttatcgtt gttaaagcag ccgaaataat 865501 tccgttatct aaagcagcca taaacacgcc aatcgtaaac aggctgattg cccacttttg 865561 gcttttctgc tctgttaatg cttcagacat tttcgtcaac tccttttagt tcacttgaaa 865621 tatattattc attttaaatg aactaaatgt caaataaaaa aagcctgctc ccgcagtttg 865681 cggatgacag acttactgat ttattctttt ttcgcattct ctaatgctct tgaaaggata 865741 gacagccctt cgtaaacagc ctgcttttct tcaggggaca gcagctctaa tgaacgcttc 865801 aatttcaggt ggcccttttc atacaaaccc cggaaaatct ttttcgcatt ctctgtcaac 865861 tgaacaacta cagagcggcg gtcctcttca gaatgtgagc gtttgacaaa tcctgatttt 865921 tcaagccggt caagcagccc agttgtattg gacagggaag cccccatttt ttcagcaatg 865981 tcgctcactt tcaatgttcc atggttgttt aatagcatca gcaccttcat ttgcggcatg 866041 ctcatatcca gtttcatcca ctcggacaca tcaccgagcc cggcggacgt taagactttc 866101 atatagagca cccatatttc ccgttcctcc gatgaaagaa tgttttcgtt taagactgtt 866161 gtatcgtgta aattatattc catttcatca cttcctcatc attcactcct cttaccatat 866221 tactcgattt tcactcctga aagaaagtga gcagaaaccg catgcgggac tttgtccgaa 866281 aaataacggt agtgtataat gagttggaga ttattggggg agaggatcga actagaatat 866341 gattggagag accattgctg attaaaaaga atgctttatc aatattaaaa atcgtttttc 866401 ctattgctgt tttgctattt gttatttatc aatcgaaaaa agaactgaca aatctgtcat 866461 tcaaacgtac gctcatggtc atcaacggac tggaacgaac ggatttattc atgcttgtgt 866521 tgatcggctt gctggctgtt gcggctatgt cgctgtatga ttacgtcctg aagtactcac 866581 tgcgcctatc gatcacaaac ggaaaagttt tcagggtttc ctggatcgcc aattcattta 866641 ataatgtgtt gggattcggc ggtttagccg gagtcgggtt aagaatgatg ttctataagg 866701 agcatacgaa agaccataag gcactcgtga aaggaatcgc ctggctcaca tcatctatgc 866761 tgctcggatt atctgttttc agcattttcg ttgctgcgag agtgctgcca gttgatgaag 866821 tgattcatga gaagccttgg ctgtgggcgg tcgttatcgg ttttgcactg atattgccgt 866881 tatctttagc ggtgtccaaa ataaaagacc gcaaagctgg ggacgaagag aatgcggata 866941 aagtgaaaaa tccgattttc gcatatattg gagcttcagt tgttgaatgg ctcatggccg 867001 ggaccgtcat ctattttgct ttgttcgcta tgggcattca tgcagatatc aggtatgtgt 867061 tcggggtgtt cgtcattgcg gcgatcggag gaatgatcag cctcgtgccg ggcggcttcg 867121 gctcgtttga ccttttattt ttgctgggga tggagcagct tggctatcat caagaggcca 867181 tcgttacttc tattgtgttg tacaggctcg cctactcatt tatcccattt atcttgggac 867241 tgttctttgc cgccggcgac ctgacggaaa atacaatgaa gcggctcgaa acgaacccgc 867301 gcatcgcacc ggcaattgag acgacaaacg ttctgcttgt tgttcagcgt gcggtattag 867361 tgagaatttt gcaaggctcg ctttccctta ttgtgttcgt agcaggtctg attgtcttgg 867421 cctcagtttc cttgccgatt gacaggctga cggttatacc gcacattccg cgcccggcgc 867481 ttttgctgtt caacggcctg tccttaagct cagcgctcat tctgctcatt ttgccgatcg 867541 agctttataa acggacaaaa cgttcctaca cgatggccat tacagcgctt gtcggcggct 867601 ttgtgttcag ctttttaaaa gggcttaaca tcagcgcgat attcgtactg ccgatgatta 867661 tcgtattgct tgtgctattg aaaaaacaat ttgtccgcga acaggcatcc tatacactgg 867721 gacaattgat attcgctgtg gcgctgttta ctgtggcgct ctttaactac aatctgatcg 867781 cgggctttat ttgggaccgg atgaagaagg tgctgcgtca cgaatatttc gtccacagca 867841 cctcgcatat tacacatgca accatcatgg cgatcatcat tgtgccgctg ttcttcttga 867901 tatttacagt ggtctatcat aagagaacga aaccgatcgg agagaaagct gaccctgagc 867961 gtcttgctgc gtttctcaat gaaaaaggcg gcaacgcgct gagccatctt ggttttcttg 868021 gagataagcg gttttatttt tctagcgatg gaaatgcact gcttctgttt gggaaaatcg 868081 ccagaaggct ggtcgtgctc ggcgatccat ctggccaaag agaatcattc ccgctcgtgc 868141 tggaagaatt tctgaacgaa gcgcatcaga agggattcag tgttttgttc tatcaaattg 868201 aacgagagga catggcgctg tatcacgatt ttggctacaa cttctttaaa ttgggtgagg 868261 aagcatatgt agatttaaat acatttacct tgactgggaa gaaaaaagcc ggccttcggg 868321 caatcaataa ccgctttgag cgggaggagt atactttcca tgtggatcat cccccatttt 868381 ctgatgcgtt tttggaggag ctgaagcaaa tctcagacga atggctcggc tcgaaaaaag 868441 agaagggatt ctcgctcgga ttttttgatc cttcctattt acagaaagcg ccgatcgcct 868501 atatgaaaaa tgcagaagga gagatcgttg cattcgcaaa tgtcatgccg atgtaccagg 868561 aaggagagat atcggtcgat ctgatgcgct atcgcggcga cgctccaaat ggcattatgg 868621 acgcattgtt tatccgtatg tttttatggg caaaggaaga gggctgtacg tcatttaata 868681 tggggatggc acccttggcc aatgtcggca ctgcctttac atccttctgg tccgaaaggt 868741 ttgccgctgt catttttaat aatgtcagat acatgtacag tttcagcggc ctaagagcct 868801 ttaaagaaaa atataaaccg gagtggcgag ggaaatactt agcgtatcgg aaaaacagat 868861 ctctttctgt caccatgttc ctcgttacac gtctgattgg caaaagcaaa aaagactccg 868921 tctaataaga cggagtcttt ttttatttcg tttttaagaa gtaggtttca atatcatcaa 868981 gcaggtagtt tgcggcttta attccgcctg cggttgtcca tacgacgtca tcgacttcat 869041 gtgcattacc tgacttcacg gccttcaggt ttttccatag tgaactgctt gtccactgat 869101 tggcccattt ttcattttct tttgcattat cggctttata agtgaaataa aacagcacat 869161 cagcatccat atcaggaata gattctttac tgtcggttga gaacgtaaat tggtcctttt 869221 gtttcttaaa cagttccact tgtttttcag ggcgtttgaa gccaagctgg tctaaaataa 869281 tcccaggaaa tgaatcggta taatagattc ttgattcacc ggataaaaag cgtacgactg 869341 aaacggtttt gtttgtctgg tcgcccagct tgttttttaa atcagaaaca cgtttatcaa 869401 aatcggcaat gacttccttg cctttgtccg ccttattcac cgcgttggcg tatagagtca 869461 ggttatcctt ccagttcccg gccaaagatt cagcaaaaac agtcggcgca atcgcattta 869521 actgatcata aattttttcc tggcgcactt tgtttccaat aatcaaatca ggctttaatt 869581 ctgcgatggc ttccacattc ggttccgttt caagaccgac gtttttaaca cctttcatgt 869641 catctttcag atagtcatac cacgggtcgc ccttccatga ctttacggct ccgaccggct 869701 taatgccaag cgctaagagc gcctctgttc cttcattagt taaaacaaca atccgttttg 869761 gattggcggg gatgttgtct gatgtcccca ttgcatgttt gaccgttctt gttttgctgc 869821 ttgacacctc gctgttgctt gaactttctg aactattaca ggcagaaagt accataacgg 869881 ccattaaaaa tacgaatagc atgctgatat gctttttcat ctttttcctc ccaatattga 869941 aattcattat catttagatc ataataagca gtgttaagag tgtcaatccc taattgagga 870001 ttattctcaa aaacaaacat tacatagtaa ataactagga gaattagatc atgatctgca 870061 aaaaggcatc ttcaaaatgg attgtgttag tatgtctgat tttcatttta ctgacggctg 870121 tctgcgcaag cgtcgtgtat ggctatacag gtacgtcatg gagacaggtc tatcaggcgt 870181 ttacttcctt caatggaaca aatgagcatg tcatcatcaa ggatgtcagg cttccgcgcg 870241 ctttggttgc gacagtcgtc ggcgcctcgc ttgcagccgc gggcgctctc atgcaggcgc 870301 tcacaaaaaa tccgcttgcg tcaccgggga ttttcgggat taacgccggt gcaggttttt 870361 ttattgttgc cggatcgttt tttctgcata ttcagtcacc tcaggcatta gtatggagct 870421 cgtttctggg ggcagcattt accgctgcga tcgtctatgc agcaggctcg cttgggaggg 870481 aagggctgac gccaatcaaa ctgacgctgg cgggagctgc catggcagcc atgttttctt 870541 ctctgacaca gggcttgctg tctgtcaacg aactcgagct tgcccaggtg cttttttggc 870601 tgactggctc tgtgcagggc cggagtctgg atctgttgat gacgatgttt ccatatgcag 870661 cggcagcgct ggtaatctgc ttctttctcg gccaaaaaat taatctcctc gttatgggag 870721 aagatgtggc aaaaggactc ggccaaaaaa caggcctgct gaaatttgtg atggcgcttt 870781 gtgttgtcat gcttgcaggg tccgctgtcg ccattgccgg gccgatttct tttatcggca 870841 tcattattcc gcattttgcc cgctttgtcg ttggtaatga ttatcgctgg gttctgccat 870901 tttccgctgt tttgggtgcc attttgcttg tttgcgcgga tatcggtgcg cgatatatca 870961 ttatgcctca ggaagttcct gtcggggtca tgaccgccat catcggaatg cctgtgtttg 871021 tgtacatcgc aagaaggggg gcgaagctat gaaacttcgt tttggcgtta ctgcggctga 871081 aaagaaagca tggatcgtct ttttggtttt actggggtta acagctgctg tactcatcat 871141 aagcgctggt ctcggacaaa ggtttattcc tccctgggat gtagcaaaaa cattctttgg 871201 tgcaggttcc aagctggatg aactgatgat catgtcgttc cgcatgccaa gaattttgac 871261 ggctttatgc gccggtgtct gcttggcagc ggcaggcgcg atattgcagg ggctcgtcag 871321 aaaccctctc gcatctccgg atattatcgg aataacagga ggagcggcgg tagcggtcgt 871381 gcttttaatg atgttcttct cagaccgcag cagttcactt acgatcagtc tgtcatggct 871441 tccagcagcc gcatttatcg gcgcatcggc tgtcgggctc atcgtctatt tactggcata 871501 caaaaatggc gcctccacat ttcggctggt gcttatcgga atcggatttt caatgtcggc 871561 gcaggcgatg actaccctgt tgatgatcaa aggcccgatt taccgagcat cacaagccaa 871621 tgtgtatatc actgggtcag tttatgggtc aaactggcag catgtaaaaa tagctattat 871681 cttatctgtc attctcttat tcatttgttt tgtcgcgcta aaaaatatga atatacaggt 871741 gctgggtgaa gatattgcgg cgggtgcagg aagcgctgtg cagcgaaatc gttttttctt 871801 gctccttttg agtacggctc ttactggttg tgcagtttca gttgccggca caatcggttt 871861 tgtcgggctg atggcgcccc atattgcaag acggcttgtc ggctcatctt atggcgcgct 871921 gctcccagcg tcggcactta ttggagctct gctcgtttta acagctgata tcgtcggcag 871981 aaccttattt gctccggtgg aagtgccggc cggcgtcttt acagcggcta tcggcgcacc 872041 ttattttatt tatttgctct ataaaacaag aaattcttaa tcgttacacc cattttctta 872101 aaaaagaaaa tgggtttttt tgataatgac tgaagattcg taattatttt tgctatactg 872161 acagagacat tgataaagaa agggcggcag atgaatgaaa gaagcagagg tattaaaata 872221 tgaagcattt acaagcagtc ccggcaaagg aaaccccgca ggcgtcgttt tgcagggaga 872281 cgattatacg gaagacgaga tgcagatcat agctgaacgt gccgggtatt cagaaacctc 872341 ctttatccga aaaagcgagt cggccgatct tgaactccgt tactttaccc ctggacacga 872401 aatgaatttg tgcggtcatg cgacagttgc ttctctttac gcattatgtg agaaaggaat 872461 gctggagagc ggtaaaacgt acagcatcca aacgaaagcg ggtatcctgc ctgtgaagat 872521 ttctgaaaaa gatggccgca ttcatatcac gcttgaacag gcctctccgc aattcaaacc 872581 atttacaggc gatcggaaaa aacttgcgga cgcactgggt atcaccgatg aagattttca 872641 tgaagacctt ccgattgtgt ttggcagcac tgggatatgg acagccatcg ttccgcttaa 872701 atcattggag gcttccaaaa aaatggtgcc agataacaaa caatttccgg aagtgttagt 872761 tgatctgcca aaagcttcag tccatccgtt tacctttgaa accgtccatc ccgacagcga 872821 cctgcacggg cgccactttt catccccgta ttcgggaacg attgaagacc ccgtgaccgg 872881 cacagcatcc ggcgtgatgg gggcttatat gaaacattat ggcaatgccg agcagcataa 872941 atttatcatt gaacaagggc aggaaattgg aaaagacgga aaagtggaga tcgaaatgaa 873001 cgaagccggc ggccatgtga aagtgaacat gacaggaaca gccgtttact cagaaacccg 873061 tattcttaaa atctaatacg gatgatggtt tacaaaaaga tgcactttcc gttatcatta 873121 tgaaatgata atcattttca attgcatagg aaggtgagac ggtatgcctc aaaccgaaca 873181 aatacatcag cattcagtac tgagggacat catacgcagc agaagatcga ttcgaaagtt 873241 taaacaagag ccagtacctt cagcagtcat tcttgacatg cttgaaacgg caaaatatgc 873301 gccaaatcac agagtgacag agccatggag atttatttac gtttccagtg agacaggtaa 873361 agcgaacctc attaatacat ttgcagcgtt ctctaagaaa tccaagccgg atatgacaga 873421 ggaaaagctt caaaatttca aaaacacact tgggcgcgtt ccgggatttc tcctcgtcgt 873481 gtttcaggaa gatgaaaacg aaagagcgcg ggacgacgat tttgcggcaa caagctcgtt 873541 gattcaaaat cttcagcttc tcgcttggga aaaaggaatc ggcatggttt ggaaaagcgg 873601 aaaaatcctt tatgacaaag aagtccatca ggcctttggt ttacaggata atgagcgttt 873661 cgccgccatc atacaaacag gttatcctga cgaggcgccg gaagtgaaaa aacgcacacc 873721 gatccgcgac cgattcactg aaatgtaaaa aaccccttgt ctcaaacgga gacaaggggt 873781 ttttcattaa cgagatttct ttttcgctct gttgtcggct gctttcgcac gctcttgcgc 873841 ttcgcggtca tctgcatcag caagctcggt tgaatattct tcgtaaacgc cgtcagtttc 873901 cctttttaag gcatcgggaa cttgtggaag cttttgtttg tttttatcac ggtttttgtg 873961 gatatgattt ctgcccatat caaattcccc ctaaaaagtg atatcaaaca aatatagtat 874021 ttggttttaa ggggctatgt attcctactt ccgcttagca gctttttccg cttttttaaa 874081 ttcgcctgaa taaagaactt cctgcatttt tttcaggttg gcgccttgct ggtgcttctc 874141 cctctttttt tccataaaaa ggacctcctt caaccatgtt attcttaagg ttgacgcttc 874201 ctgctgtttt tatacagtct ttcggtccgc tatcagctgt gagagtgcaa attcaagatc 874261 cgaatatgta aaacgaaatc cagaggttat cgcttttttc ggaagagcgc gctgtccttt 874321 cacaatcaaa agactcattt cacccaatgc ttttgataaa aagaattccg ggacggggag 874381 ccagtgcggg cggtgcttca cccgtgcaat cgtttttccg aattgcttca tgtccacagg 874441 attgggcgcg gtgacattca ttgggcctga gatgccggcg ttttccaccg catatcggat 874501 catctgggcc gcatcctcga catgaatcca tgacagccac tgccttcccg ttccgatcgt 874561 tccgccggcc agaaacttat aggggagaat catgagcggg agagcgcctt tttctccaag 874621 catcacgcca aatctcgcat aaactgtccg gatgcccatc gcttcaatat gctgtccttc 874681 cttttcccac aggtgtgcag tatggctgag aaaatcctca tctgacgttg cagaatcctc 874741 tgtgaaagtt ttctcaaggc ttgtgccgta aatgcccacg gcactggctt ggatcaatgt 874801 cttcggcttc tccttctgtt tctgaataag ccgctgcact tcacgcgtcg cattgatacg 874861 gctggagaga atgtgctgct tcgttttttc tgtccagcgg ccaaaaatcg attttcccgc 874921 aagatttatc cagacatcaa tatgaggaag ttcctgctcc ggtgcggctc cttccgacag 874981 ccattggaca tatgtcatat ttttttgttc agtttccctt gcgtttcttg ataaaatata 875041 aacatggtgt ccctggcggg taagaacgcc tgtcagatgc tggccgagaa aaccggttcc 875101 gcccgtcatt gcgatattca tgaacatctc tcctcatcgt tctaataaat atactttacc 875161 tcattgtaat aaaagaaaac gcgtttcagg cctgagaagg gagattaaga tgccgtttat 875221 tacaaaaata tcaacgcaaa aaaagaatac ggaacgcttc aatatttttc tggatgataa 875281 atacgccttc agcgtggacg cggatgtgct cgtgaaattt gagctcaaga agggaaaaga 875341 actcgatgat cttgacatca ttgagattca atacggcgat gaagtgaaga aaggcttcaa 875401 ccgtgcgctt gactttttat cctatcgaat gcggtcgacg aaagaggtcg aggatcactt 875461 aaagaaaaaa gaaacctcgc cccccgtcat tgcggaagtc atccataggc ttaacgatta 875521 caagtactta aacgaccagg aatttgccgc agcctatgtc agcactcaca aaaaaacaaa 875581 cggaaaaggc cctgatgttt tgttcagaga gctaagagcg aagggaattg atgacgatac 875641 aattaaggag gcgctaagtt ccttttcctt tgaagatcag acaagagaag cggtcaagca 875701 tgttgaaaag cttctcaaaa aagataaaaa gctttcgacg aaagaactca aacagcgcgc 875761 ccagctgcag cttcagcgca agggcttctc atttgatgtt atcagcgcgg cgatggatca 875821 gattgaatat gaaaatgatg aagacacaga gaaagaagcg ctgcgccttc acgcggaaaa 875881 agcgtttaga aaataccgct atgacggctc atatgaaagc gccatgaagg tcaaacaatt 875941 tttattccgc aaaggattct cactcgattt aatcgagcaa ttactgcagg aagaggagta 876001 ctgaaatgga gaaacgatac agtcaaatga caccgcatga actcaatacc gaaatcgcat 876061 tactttctga aaaagcaaga aaagccgaac agcatggaat cataaacgaa ctggcagtgc 876121 tcgaacggaa aattacgatg gcaaaagcat atttgctgaa cccggaagat tactcaccgg 876181 gagaaacata tcgtgtggaa aacactgagg acgagtttac catcagttat ttaaatggcg 876241 ttttcgcatg gggatacagg acctcttccc ctcagcaaga ggaagcgctg ccaatctcag 876301 tattgcaaga aaaagaataa agcgtaacag gaggctgatg atcagcctct ttttgtttgc 876361 agcacattta cacgaattct taaagaaaaa atcattgaat tcacttgaaa aatcttttaa 876421 gatgaaactc gttgtttttt aaaatcaaag gaggcgatga cgttgagtat caaaaaccca 876481 tctgtaaaat ttattatatt tgttcttatg atttgtacat tttcaatcgg ctatacagaa 876541 tacgcggtga tgggtatttt gacgtcgatt gccaatgact ttcatataca ggtttcatcc 876601 gcagggcttc ttgtcacggc ttatgcggca agcgtttgtt tgacagggcc gctcgtcacc 876661 atcatttccg tcaagcttcc gagaaagcct gtgcttcttg ggctgatggc gatatttatc 876721 ctttccaacc tgatgagcgc actggcgccg aattttgcgg tattggccat ttcaagaatt 876781 ttatctgcgt ccattcacgg cgctttcttc gcgattgcca tggtattcgc aagtgaaatg 876841 gttccgccgg aaaagcgtgc tgcagctgct gcttcaatga acggcggact gacagtggct 876901 ctaatgcttg gtgttccatt cggctcttat ctcggagatg tcctgaattg gagagcggtg 876961 ttttccatca ttacggcact tggtgtcatc ggatttttag gccttatggc tgccgtgccg 877021 aacagaaaac caaaagtgat cccaatgctt atgaatgagt ggggtgtttt taaacacaaa 877081 caagtgctgt tttccttcgc gattaccatt ttaggctatt ccggtgtctt tatcgcctac 877141 acctttatcg aacccatttt gaggcattca gccggattca gcacggttgg cattacaggt 877201 gctctctttg cgtatggatt gggaggcgtt gccgggaatt tctttgctgg aaaggtaccg 877261 ctgcctttgc tgactcggac gatgatcggc gtaatgatcg gtttaatcgg tgttctggct 877321 gtatttcctt acatcgccat ttacccggct gcagccattg tggcaacgtt cctattcggg 877381 gcatgcgcat tcggcacgcc gcctcttctg caaacaaagg tcatttcctc atctgagggc 877441 ggcacaacca ttgccgcagc tgtcagcgta tcagcattta accttgccaa tgcccttggt 877501 gcatggatcg gcggaatgat tttaaacgga acaggctctt attcctggct gtttgcagga 877561 ggtgcgctta tgaccgcatg cggacttgtg ctttctacct tcgcacactt atcagaaaag 877621 aagagcgtct acgaatatca agtcaataaa gggtaaaaaa cagctgcagt gtatgcagct 877681 gttcttcttt accgtttgcc tgaggctctc attctttctt gaggatgctg attgatagat 877741 ccgtcagcac gctttgaagc atagtcgtcc tttgctctcg gttcaccctg aaatttgttt 877801 tcgttttcgt aaggaaatcc tttttcttta tttcggacca tgtcatatcc ccctaggttc 877861 gagatcaaaa agttgcgtct tttcagatga agacgtaagg ttagtatatg gagaacacca 877921 cgtaataaag cgttattttt ttcctgaaga aaggagactg cacacatgaa tatgtacatt 877981 gagaaactga ctaatctgct tctggaaaag aacgagatga tcagctatat acaggcaaaa 878041 acgtgggtgg aattgttatg gagcgatttc gaagcaacct acgcaaaagc cggacacgcc 878101 tatcaaggtg aaaaaatgac tgaaaaaatc gtcacacaat ggattgaaaa ctatggcggc 878161 cagctccacc tttttcaaag ctcccgtaac gacgtgaatg attacttaaa tcaaagcaga 878221 ggccttttgc attaaaaacc tgccgttaac gaccggcagg ttttttcatt ttcttaaaat 878281 taccttaaca ggaagaaatc ataaacaaaa catgtttcac cagcctgtca atcagggaat 878341 accacttata tcttgtcaaa atgcgaggag gagctttata tgaaaaagaa acaagtaatg 878401 ctcgctttaa cagctgccgc aggactgggt ttgacagcac ttcattccgc tcccgcagca 878461 aaagctgcgc cccttcacga catatctgtc agcatgccat catccgatac ttacatcata 878521 aaagcaggaa agctgaatgt ccggactgag ccaaatcatg aaggtgatat tctcggcact 878581 gtatcatcag aacaaaaggt aaaagtcgat aggttcgtaa atgccgattg ggctcaaatt 878641 catttcaaag gaaagaaagc atatatttca actcactttt taatgaaaac cgcaagccaa 878701 gcgaaaacaa cgaaacagac agccttctat acaccgacgc ccgaaaacgg aaaagctaag 878761 cagctctcat ctggaacaga ggtgacaata cttgggtggg gattcagtga aaacggcgga 878821 tttgacttca cttgggcgtt cgtggattat ggcggagtta aaggctatat tcacacaaag 878881 gatttacaaa tgcgataaaa aggcaggccg aggcttgtct ttttgcctat gcatgaaaca 878941 tttcttcttt ctgcacgtaa caatgagaaa ggagatgatg atatgacggg tttagtcggc 879001 ggagggctta tgatcattgc gggcatactg atcaaactgt ttcctcccaa atcgatcaac 879061 agtgtgtacg gatacagaac gagacgctca atgtcagatc aaagattatg gaatgaagcg 879121 aaccgttaca gtgcatcatt aatgatcctg tcaggcttgg tgattgcggg aatgggtttg 879181 ctgctgggat caaacttgtt tattcttcag cttatcctgc tgattgccgc ctgtgtcata 879241 acatttatgc taacggagaa aaggctgaaa atcatgacgc acagtcaagg aggagataga 879301 agtggacgga gttaaatgcc agtttgtcaa tacgaacgga atcacgcttc acgttgcagc 879361 cgcaggacgg gaagatggcc cgttaattgt cctgctccat ggatttcctg agttttggta 879421 cggctggaaa aatcaaatca aaccgcttgt tgatgcgggt taccgggtca ttgctcctga 879481 tcagcggggc tacaatctca gtgacaaacc ggaaggaatt gattcgtatc ggattgatac 879541 attaagagat gatatcatcg ggcttattac gcaattcact gatgaaaaag caattgtcat 879601 cggtcatgac tggggaggag ctgtcgcatg gcatttggct tccacacgcc cggaatatct 879661 tgaaaaactg atcgcgatca atatcccgca cccgcacgtc atgaaaaccg taacgccgct 879721 ttatccgccg caatggctga aaagctcgta tatcgcatac ttccagctgc ccgatatacc 879781 ggaggcatca ctaagggaaa atgattatga tacattagac aaagcgattg gattatccga 879841 ccgtcccgcg ctttttacat ccgaggatgt cagcaggtac aaagaagcgt ggaagcagcc 879901 gggcgcgctg acagctatgc tgaactggta cagagccctc agaaaaggaa gcttggcaga 879961 gaaaccctct tacgaaacag taccttaccg aatgatctgg ggaatggaag accgcttttt 880021 gagcagaaag cttgcgaaag agacggaaag gcattgcccg aatggacatc tcatctttgt 880081 tgatgaagct tcccattgga ttaaccacga aaagccagcc atcgtcaatc agctgatttt 880141 ggaatatctt aagaaccaat aagctaaaat ttctctccat ccgtctgtca taatggcaga 880201 ctttttctgt gcgttttttt tcatagtctg ttttaaacat gacaaaataa cattaaaaat 880261 catgaatgtc accataaaat tgtaacaaaa aacaggttta aacgacttta aaaaaaggaa 880321 tagccttact gaagatttgt gtaaaactcc cctaaggcaa tacttaaaaa gaataataaa 880381 aagaaggtgc cttaatgaag caaggattaa tctcgattat tatcccgtct tacaatgaag 880441 ggtataatgt taaactcatt catgaatctt taaaaaagga atttaaaaac attcattatg 880501 actatgaaat attcttcata aacgacggaa gtgttgatga cacgcttcag cagatcaaag 880561 acttggcagc gacgtgcagc cgggtaaaat atatatcttt ttctcgaaac tttggaaaag 880621 aagccgcaat tttggcgggc tttgagcatg ttcagggcga ggcggttatt gtcatggatg 880681 ccgatctgca gcatccgaca tatttgctga aggaatttat caaaggctac gaagaagggt 880741 atgaccaagt cattgcccaa aggaacagaa aaggggacag ctttgtccgc tcactcttat 880801 catctatgta ttacaagttc attaataaag cggtggaagt cgatttgcgt gacggtgtcg 880861 gtgacttcag attgttaagc cgccaagctg tgaatgcact tttgaagctg agcgaaggaa 880921 accgcttctc aaaaggcctt ttttgctgga ttggctttga tcagaaaatt gtattttatg 880981 aaaatgtcga acgaaaaaac ggcacctcca aatggtcgtt cagcagtctg tttaactacg 881041 gaatggacgg cgtcgtttca tttaatcata agccgctgag attatgtttt tatacaggca 881101 ttttcatcct gctgctttcc atcatttata tcattgccac attcgttaaa attctgacta 881161 acggtatttc tgtgcctggg tatttcacca ttatctcagc agtgttattt ctcggcggag 881221 tacagctgtt aagtcttgga ataataggtg aatatatcgg ccgaatctat tatgaaacaa 881281 aaaaacgccc gcattatttg atcaaagagg cgaatatccc gaacaaagac ctgcctgaaa 881341 cgaacgaatt aaaaagcatg cggcgtctga caaaaatgca ctgaaaatac caagcgccat 881401 tggcagtgct ttttttgcgt gtctattatc ttaaaagcaa gactggagaa ttcatatgaa 881461 aagaaaacat atcatgatct atgcggccag tttgctggtg tccgttctgg cacacgcttt 881521 ttttgtgaaa gaatgggcgg aaggcaggta tatgacaggt ccgggtgacg ggcttgcgca 881581 aatgatcgta tttaaaaaat tattatttga ccaatataca cacgggaatt ttttctacaa 881641 ttattcattc ggacttggcg gcggcacatt cagtcagctc ggctattatt tttctgcgtc 881701 ttttcttttt cttgctgtgt ctgccgctgt ttggctgctt caagccgtcc agctgatcgg 881761 agaaacggat acgctttttt gggcagagtc agctgttttt atcagtattt tcaaattgag 881821 cttgatcatc tttacgtccg cttctgtttt tcattatctt cttaagcaca gggcggcatc 881881 gttcacggga gccgtgttat acggcgtctc aattatttat ttccgtcacg aagcgtattg 881941 ggaatttttc accgatacaa tggtttggct tccgctgctt gtgcttggcg cagaaaaaat 882001 tattagagag cggcgtccgg cgtggtttat cgttgcgtgt tcgctgacgt taatcaacaa 882061 tttttacttt gcatacataa accttatatt catcggaatc tatgtgctgt tcagatggct 882121 gatccgtttg gaaccacatg aagagaaaag atggattcaa atcagattat ttctcgtttc 882181 aggcttcatt tcttttggca tcagtgcggc ggcgtttgtg ccggtagtat acggtttttt 882241 aaacaacctg cgccctccat acagccagaa aatagagtgg ctcaatttcg atgataatat 882301 cttattttcg agccggatca tcattgtgcc ggccgctttt ctgctgtttt tgtttattat 882361 ttctttttac aaaaaccgtg tgtttcgtct ctttgccggg ttgagcctgc tgtttattct 882421 gtttcatttc agtccgtatg cggcaagcgt ctttaacggt ttttccgccc cgcaaaaccg 882481 gtttgaatat gttctggcct ttaccattgc gggagcagct gcggctggtt tgtcacagct 882541 gtctgaattg aaacggaaag aactgctccc ggccgcagct gtcgtcctgc ttctttactt 882601 gtatcatatc caaaggtata agctcgatat atggaagcct gcgaatgaaa gtattctatt 882661 gctcttactc atgacaatcg cagccttgtt tgctgcagct tttgcgaaaa aacgggcaaa 882721 aatggctgtg tacggtataa tcattctttc ttcgctgttt gtcgccaact cctatcaaaa 882781 atacgcgctc tcagaaggcg gcgatttgga cagtgtgaca aaagaatatc ttacaagtga 882841 ggaatacaga gggcgggaat catctgagct catcagacgt ttacagaagg aagacgatga 882901 cccgctcatg agaatcgact ggatgaacgg ggtccgcaat aatacgccaa tcatttacgg 882961 atttaatggc ttcagcgcgt attccagcat tttaaacaaa gatctgctgg ccttctattg 883021 gaatgattta agcatcgata tgggcaggga aagcgtcagc cgttacgcgt cattgggaga 883081 cagggcgaat ttatacagcc tgctttacgg caaatattat atgaccgaaa aaacaaacga 883141 agccagcgtc ccgtacggct tcaaaaagca tttagaaaca gagcattatg cagtttatga 883201 gaatcagtac atgcttccat tcgttaaaac agcggatgcc atatacagcg aaagtgagct 883261 ggaccgattg cccgctcttg cgaaagaaca ggcgatgctg aaaggaatta tattaaaaga 883321 tccatcagga aaaacggagc agacaccaaa accgtccaat ttgatcacca agtcggacat 883381 caccgcaaaa caagcccagt atcaaaacgg gctgctaacc gtaactggag aaaacggagg 883441 agagctgatc atcaccccga aacagccatc atccgctccg ggagactact atgtcagctt 883501 ttatttgaaa agcaaagcaa aagacaaagg atttacatta aaggtaaatg attatgtcac 883561 aacaaggaaa tcgaacaaat cgatctataa aaccggagta aataatataa cggtaagagt 883621 gcctaaatca ggccatatct caatcaatct tccgaaagga acctatgagc tgagaaacat 883681 agcgctctat gaagaaaatt accaaacgct gaaaaacgct gtaatgcaaa ataaaacaga 883741 gaaagcagac aaactgaatt ggaacaaaaa tcgactgacc ttttcctatc atctgtcaaa 883801 agaccagtac atcatgcttc cgatcccata tgaaaaaggc tgggagctga agatcaacgg 883861 aaaaacacag aagatcgaaa aagcggatta tgcttttata ggcttcaagg cgcaaaaggg 883921 agacaatcac attgagctga cttactatcc gccatacttc aaaatatcgg cgatcatatc 883981 tctcgtcagt ctgctgcttg ctgtttttta tataagacgt aaaaagcccg gctctatata 884041 gagccgagct ttaatttttt ctgaagtttt tcttcgctga atatccatcc cgtataggat 884101 gaacgaatcg tgagatcatg gccgatatga acaattgcga caaacggata atggcctttg 884161 ctccgataac gcaggtcgat aaatctcacc tcataatgat ctttaaacgt atccacttcc 884221 caccggtata ccggagaaaa ggacagaaac gccgcgatgt tatcatcctg ctttgccgca 884281 tgcattacat cggtttcagg aacaggcacc cgattaaatg tatccagaat cacgacatgt 884341 ccttccatgc ttcttcctac atagaaagca tgtgctgtcg tcactgcgat tcgccattgc 884401 ctgaatttca tcgttggaga aataataatg ctttcgatct catcatgaat catctcatga 884461 agcttccgtt taattctcag ctgcatgatc aggcgcacca agtagtagcc taccaatatg 884521 atatataagc tgagaaacgt gatgccggga ctcccgcctg cataccaaat cgcgatagct 884581 gccagatggc tgataaaaat aaacggatca aacgtattaa tcagcccgag cgcaacccat 884641 tttttcgaaa acggacgaat ggcttgtgtt ccataggcgt tgaatatatc aacaaagaca 884701 tgcagaacga ctgccagcag tgtccacagc cacaggtgca gaaaatcggc ctgaggataa 884761 aataaataca gaatcgccgg gatgatgaca gaccaaaaca aaacggcggg aattgaatgg 884821 gtaaatcctc tgtgattcct tatataaaca gcattgtttt taagctttaa cacagtatca 884881 atatccggag cctgagagcc cgcaagcgtt gcgatcataa cagcgtgagc cattgccgga 884941 tctgatccga caacaggatc aagcgtcgca ataccgccca gtgcgatgcc cataacgaca 885001 tgtgtgcccg tatccatagg tgacctcctt gcagggtgat cctgcacatt cactttgtaa 885061 gaaattcccc attttcatat acccaatttt taaactgatt caatcgttct catatgtttc 885121 cgctttttct ttattactat ttaatgtaac atattatcgt actgtgccct tagtgtacaa 885181 caaaaaacag tctaaagaaa agcggggcgc gaaagactgg ggagaaacac atatgaacgt 885241 acttgaagac aaattaaaac aaaaagacat acagcaattt cgcgatgatt taatctcatg 885301 gtttgaacga gagcagcgcg ttttgccgtg gagagaggac caagatccat ataaggtgtg 885361 ggtatctgaa gtgatgctgc agcaaacgag agtagagaca gtgattcctt actttctccg 885421 gtttgtagaa caattcccga cagtggaagc gctcgctgat gctgatgaag aaaaggtgct 885481 gaaagcatgg gaagggctcg gctattattc gcgagtcaga aacctgcaaa gcgcggtaaa 885541 agaagtgaaa caggaatacg gcggcattgt tcctccagac gagaaagatt ttggcgggtt 885601 aaaaggcgtc ggcccttata caaagggagc ggtgctcagc attgcctaca ataaacccat 885661 tcccgcggtt gacggaaatg tgatgcgtgt catgtccagg attctatcta tttgggatga 885721 tattgccaaa ccaaaaacaa gaacgatctt tgaagacgcc atacgagctt ttatttccaa 885781 agaaaaacca tctgaattta atcagggctt gatggagctt ggagccttga tctgtacgcc 885841 aaaatcaccc tcatgcctgc tttgcccggt tcagcagcat tgctcagcat ttgaagaagg 885901 cactgaacgg gagcttccgg taaaaagcaa aaagaaaaag cccgggatca aaaccatggc 885961 cgcgatcgta ctgactgatg aagacggaca agtgtatatc cacaaacggc cgtctaaagg 886021 tttgctcgcc aacctgtggg aattcccgaa tcttgaaaca caaaaaggga tcaaaactga 886081 gcgtgaacag ctcattgctt tcttagaaaa cgaatatggc atacaagctg atatcagtga 886141 tctgcaaggt gtagtcgagc atgttttcac ccacctggta tggaatattt cagtgttttt 886201 cggtaaagta aaacaagtgt cggataccag caagctgaaa aaagtaacga aagaagagct 886261 cgaacaattt gcgttcccgg tgtcacatca aaaaatctgg aagatggcag gagaagcagc 886321 cgccatctcg gctgctccgt aaaccattct taatcgtaag agacgcgcgt gccgtggctg 886381 tagtccgctt cattgcgctt cattccgccg cgcgcttcaa tttcttgcgt taattcccgg 886441 tattttgatt ggccttcttc gttcaaataa ggcataattt gctgaaaggc atgatgaaaa 886501 taagcgagtt cactgttctt ccaatctttt ttggaaacca tgttcaattc gctcatatca 886561 cgtccgacat acataacaga agaccccctt taaagttctt gccattattg tttgtggaaa 886621 taaaagaact atacgctaca aggagatgag gaaaaatgga acaaaataaa tgtgcactcg 886681 taacaggaag cagccgcggt gtcggaaaag cggccgcgat cagacttgct gagaacggct 886741 ataacatcgt cattaactat gcacgcagca aaaaagcagc attagaaaca gcggaagaaa 886801 tcgaaaagct tggcgttaaa gtgcttgtcg taaaagcaaa cgtaggacag cctgcaaaaa 886861 tcaaagaaat gtttcagcaa attgatgaaa cgttcggcag acttgatgtt tttgtcaata 886921 atgccgcttc aggagtacta agacctgtca tggaattaga agaaacacac tgggactgga 886981 cgatgaacat taatgcgaaa gcattgcttt tctgcgctca ggaagctgcc aagctaatgg 887041 agaagaacgg tggcgggcat attgtcagca ttagttcatt aggctctatc cgctatcttg 887101 aaaactacac cacggtcggt gtatcaaaag cagcgttaga ggctttaacc cgttatcttg 887161 ccgttgagct ttcaccaaaa caaattatcg tcaatgctgt ttcaggcgga gcgatcgaca 887221 cagatgcgct gaagcacttc ccgaatagag aagatctgct tgaggatgcg cgccaaaata 887281 cgccggcggg acgcatggtc gaaattaaag acatggttga tactgtggag tttctagtgt 887341 cttccaaggc tgacatgatc cgcggacaga caattatcgt tgacggcgga cgctcactgc 887401 tcgtttaaaa atttttaaaa aagaggaata gctatacgat cacctgcaca ttctaatgac 887461 cgtggaggtg ataacaatgg ctaactcaaa taacttcagc aaaacaaacg ctcaacaagt 887521 tagaaaacaa aaccaacaat cagctgctgg tcaaggtcaa tttggcactg aatttgctag 887581 cgaaacaaac gctcagcaag tcagaaaaca aaaccagcaa tcagctggac aacaaggtca 887641 attcggcact gaattcgcta gtgaaactga cgcacagcag gtaagacagc aaaaccaatc 887701 tgctgaacaa aacaaacaac aaaacagcta atcactgaaa cagaaaaaag cacttcatct 887761 tcgggtggaa gtgctttttt ctgtttgaaa aacgacaaaa cttgtggaag gtctacagaa 887821 tgagtcaaag ggtttgcttt atggagatcg aaatgattaa aggaggaaat gtttatactt 887881 tcatcaggct gaaggaggaa ccgatgaccg aatttgaaaa gctggtaagt gaacagatga 887941 aaacgatgga taagcttctc gatctccaat cagagctcga ccgctgcaaa caaattgagg 888001 cggaactccg gcatttggaa agggatgcaa ggctgcgtgg gattcaggct gaaattgcgg 888061 taaaacggaa acaccttgcc gatatacagg atatgtttca aaagcagaca gagcaggtca 888121 ttcgttcata tcgcagctca gaaaagccgt cttcctttgt gtagtgcagg aatgtgccat 888181 tccccggccg gaatggctct tttattttca tttttcaatt tgtaacgtta taataggtaa 888241 aagacgttgt cggtaagcaa atttggacat actaactgta gggctttata gaaagtaggg 888301 gagaaatatg ggctatccca aggaaggaga aaccattcaa attcacagct ataagcacaa 888361 cgggctgatt catagaattt ggaatgagac aacaatctta aaaagtacag aaatgtgtgt 888421 catcggagcc aatgaccgga cgatggtaac cgaatcagac ggccggacat ggataaccag 888481 agagcccgca atctgttatt ttcacgcaag acaatggttt aatgtcatcg ggatgctgag 888541 ggaagacggg gttcattatt attgcaacat cagttctccg tttgcctatg atggcgaagc 888601 aattaaatat attgattatg acttagatgt taaggttttt cctgacatga cctacaatat 888661 tctcgatgaa gacgaatatg atgatcatcg gaaagccatg aattatccaa aagaaatcga 888721 cagtatttta agagactact taaatacgct gctccattgg attcaccagc gtcagggacc 888781 gtttgcgccc gagtttgtcg atatgtggta tgaacggtat ttgcgctata caaaataatg 888841 gttacgtaaa aacctgttgc ggggtacaac aggtttttca catgggctca cacacatcat 888901 gataaagaga gagggggaat caaccgtggg ggttatgaaa cgctacatgc aattcgtcaa 888961 accttataag aagcaaattt tcgttacagt gttaatcggg atcgtaaaat tctccattcc 889021 gcttgctctc ccattgcttc tgaagtacgt agttgacgac attattcaag gaggcggcac 889081 ggccagtgac aaaaccacgt cattgttcac gattatggcg atcatgttcg ccttattttt 889141 aattttgcgc ccgcctgttg aatattaccg gcaatatttt gcccagtgga ctgccagcaa 889201 ggtgctttat gatataagag ctaagctgtt tgaccatata caaaaactga gccttcgttt 889261 ttacgcgaat acaagaacag gggaagtcat ttcccgagtg attaatgatg tagaacaaac 889321 aaaggatttc gtcatcacag ggctgatgaa tatatggctc gatatgctga cgattttgat 889381 tgtaatctct atcatgctca cactggacgt taaattaacg ctgatctcta tcgttttatt 889441 cccattatac ggaatatcag tgaagtattt ttacggccgt ttacgaaagc tgacaaggga 889501 gcgctcacag gctcttgctc aagtgcaggg gcatttgcat gaacgcattc aaggcatgcc 889561 tgtcatcaga agctttgcga tagaagatca tgaacaggct caatttaatg agaaaaacgg 889621 tcatttctta gataaagcca tccgccacac gaattggaac gcgaaaacct ttgcggtcgt 889681 taataccatt acagatttgg cgccgctcat cgtcatagcg tgcgccgggt attttgtcat 889741 taatggaccg ctgacagtcg gaacaatggt cgcgtttgtc ggatatattg acagaatgta 889801 caaccctgtt agaaggctga tcaattcctc tacaactttg acacagtcaa tcgcatcaat 889861 ggacagggtg tttgaattta ttgacgagcc ctatgaactc actgacaaac caaatgcgat 889921 aaaggccgat cagattcgcg gaggagtgga gtttcaaaac gtttcgtttc aatatgagaa 889981 ggacaaagaa aatattcttc atgatgtatc cttaaaagta aatagaggag aaactgtagc 890041 tctcgtcggc atgagcggag gaggaaaatc aacgctcgtc agcctgatcc caagatttta 890101 tgatgtaaca agcggcagac tgctgattga tgggacggat attcgcgatt atgaagcaag 890161 aagccttcgc aaccaggttg gtatggtgct tcaagatacc tttttattta gtgaaacgat 890221 tcgggaaaat atcgcgatcg gcaagcctga tgccacactt gaagagataa tcgaagccgc 890281 caaagctgca aatgcccatg aatttatcat gagttttcca gaaggatatg agacccgggt 890341 gggggaacga ggcgttaagc tttcaggcgg acaaaagcag cggatctcaa ttgcgcgggt 890401 attcctgaaa aatccgccgc tcctcatttt agatgaagct acatcagctc tggatttgga 890461 aagtgagcat tacattcaag aagcgatgga caaactggcg aaggatagaa caacttttgt 890521 tgtcgcccac cgtttatcga caatcaccca tgcggataag attgttgtca tggaaaacgg 890581 gacaatcatt gaaatcggaa cccatgatga actcatggac tatgagagcc aatacaagca 890641 cttatttacc attcaaaatt tgaactaaaa catcaatctt atatcctttt aacgaaggat 890701 ataagatttt tttgtatata aaaaaacccg gctgtttaac cgggttactc ttctgtttct 890761 atttcgcagt ctttcggatg atacgtttga aaacttgtga taagtgtttc taaatgttca 890821 agctgctcgc gatattccac ggcgcttgcc ataatattga gcatgttgta atcaataagc 890881 tcctcatccg tattctgctg attttttaaa aatgactttg ttaaaagctg cttataccgg 890941 atgccttctt caaccgcgtc atcatgcggc ttgatttttc cgacaaacct catcaaaatc 891001 cgctcgtgcc agtaaagcag gtaatcaagt tcttcagtca atgtttcctg aaactcttcc 891061 ggcatatgat agatctcgtt ttccagacga tgcagcttct tcaatgtatc aagcgcccga 891121 tttgcagtaa taatggcctg tctgaacagg acaagctttc ttgatttcac ataagtcgtt 891181 ttcttaaagt aacttctttc ttctttatat agaagatatg tctgatcaag cttgatcatt 891241 ttttctttca gtttttcaat atcctctttc aaaatcgaat gctctgtcga ctgccgcatg 891301 gacaatctga tccacttcat aatttcttcg gtgttttcga cggtattatg aatcagcttt 891361 gtttcgtact taggaggcaa aaacacaagg ttgacgataa aggaagaaag cacccctaag 891421 atgactgtgc ttgttctgat cagcgcgaac attaaaaagt cgtcaccggc agattctaat 891481 atcgcaatga ctgttacaag agcaattgaa attgtatgtt caattttaag tttcagcatg 891541 attgtaatga caataactgc tgttaacccg atcataatcg ggctgggtcc gaaaataagg 891601 ccgaacactg tggcaatcac agctccgatg atatttgctt gaacctggtc aataataatg 891661 agaaaagagc ggtaaatcga cggctggatc gcaaatatcg ctgcaattcc agcgaaaatc 891721 ggcgcgggaa gcccgatcca cgaagccaaa taaagggcaa gtgtaatcgc aatcccggtt 891781 ttgaaaatgc gggcaccaag tttcattggt ttgtgcgtgc attcctttct atagtaaatt 891841 gtgtgacata gcaaatgggc taatccttaa aattcccggt tagtttattt gctaaacaat 891901 taagtaatat acagggatcg atacaaatat tcaagctatt tttctagaaa aagaccaaaa 891961 tcttacacgc tgtttgattc cataaaaaaa caggagctca aagctcctgt tcaaggtatt 892021 tgattctagt tttttagatg tttaaatgca tcctcgaccg ctgtaagcgt gtctttaata 892081 tcctgctctg tatgtgctgt ggtaataaac caagcttcat acttagaagg tgctaaatta 892141 attccgcgtt ccagcatcag cttgaaaaac gtagagaatg tttctccgtc actccgttca 892201 gcctgctcgt aattttccac tttctcatca gagaagtata ccgtgagcgc accttttaac 892261 cggttgaccg taatggtgat gccgtgtgtt tctgcgtgct tcaaaatgcc ttcctcaagc 892321 atagcgccaa ggtgatcaag cttttcatac acgccttttt ctttgagcac ttccagacaa 892381 gcgatgcctg ataggatgga agcggggttc cctgccattg ttcctgcctg ataagcaggc 892441 cctagcggag ctacctgctc catgatttct tgtttgccgc cataggcccc aatcggaagt 892501 ccgccgccga taattttccc gagtgctgtt aaatctggtt tcacctgtaa gagatcctgc 892561 gcgccgccat acataaagcg gaaagccgta atgacttcat cgtaaataac gagagcccct 892621 gcattatgtg ttaattcatt tacttgttct aagaagccct ctttcggctc cacgataccg 892681 aagttgccga caatcggttc aacgagaacc gccgcgattt cactgcccca tttttcaaga 892741 gctgctttat agctatcgat atcattaaat ggtactgtga tcacttcgtt tgcaatgctt 892801 ttcggtacac cggctgagtc tggtgtgccg agagtagacg ggccggagcc tgcggcgaca 892861 agcacaaggt ccgaatgccc gtgatagcag cccgcaaatt taatgatttt tgtccggcct 892921 gtatatgcgc gagccacgcg gatggtcgtc ataacggctt ctgtacccga attgacgaat 892981 cttactttgt ccatagcggg aatggcttct ttgagcattt ttgcaaatgt aacctcgtgt 893041 ttcgttggtg ttccatacaa tacaccgttc tctgctgctt ttttaatcgc ttctgtaata 893101 tgcggatggg catgtcctgt aataatcgga ccgtacgccg ctaaataatc gatgtatttg 893161 ttgccgtcca catcccaaaa ataagcgccg cttgctttct ccattgcaac aggagaaccg 893221 ccgccgactg ctttatatga tctagacggg ctgtttacac cgccgacaat gtgctgtaat 893281 gcctcattgt gaagttcaat tgattttgta tgcaagaata aaaacctcct atatctccat 893341 gcgtcctttc tattgtagca tgcttccgaa caagaacaat ggcttcgggc ttcagattca 893401 gctgagatgg ttgtaatctg gacaagaatt ggatacgctt aataaaaaaa catccggagg 893461 taacgtaatg actatagaaa tcggacaaaa agcgcctgat cttgagttaa aaggtgatca 893521 tggggaaaca gtaaaattat cggattataa aggaaagtac atcgtgcttt atttttatcc 893581 aaaggacatg acaccgggat gtacaactga agcatgcgat tttcgggaca gtcacgaaag 893641 cttcgccgaa ctggatgccg tcattatcgg cgtcagcccg gacagccagg aaaaacacgg 893701 aaaatttaaa gagaagcata accttccatt tctgcttctt gttgatgacg agcataagct 893761 ggcggaagca tttgatgtgt ggaagctgaa gaaaaacttc ggaaaagagt atatgggaat 893821 cgagcgttcc acttttttaa ttgataaaga aggccggctc attaaagaat ggagaaaagt 893881 aaaagtaaag gaccatgtag ccgaagcgct tcaaaccctc aaagatatgt ctgaaaagta 893941 aatctctatg agcctatgct tacttttacc ctgatatcaa ttgacaaatt atcgtagaaa 894001 gagttacact aattataaac attacaatgt aagaattttt tttagaagag aggtgcatga 894061 cggatggctg cacatgaact aaaagaagcc ttagaaacgt tgaaggaaac cggagttcgc 894121 attactcctc aacgtcatgc gattctggaa tatctcgtta actctatggc tcatccaaca 894181 gcggacgata tatataaagc tctggaaggg aaatttccta acatgagcgt agcgacggta 894241 tataacaatt tgcgtgtgtt ccgggaatca ggtttggtaa aagagctcac atacggtgat 894301 gcttccagca gattcgattt tgtcacatcc gatcactatc acgcgatttg cgaaaactgc 894361 ggtaaaattg tggacttcca ctacccgggc cttgatgaag tggagcagct cgctgcccac 894421 gtcacgggct tcaaggtaag ccaccaccgt ttagaaattt acggcgtctg ccaagagtgt 894481 tcgaaaaaag aaaatcatta aaaataagct gaccgcacga aacggtcagc ttattttatt 894541 tcgacatttt ctttttatta taagactcat caaattcttt tccttctaat cccttatcta 894601 aagtcagcgg ctctcggcaa tgcatgcaca tatcgactac tcctaaaacc tttgtctctt 894661 tatcacagcc tggacaaatg acgcgaaccg ctttagtcga aagcattccg atccaaaagt 894721 aaactaccgt gctgagaccg atggataaaa gcccaagtat cataaacaaa ctagaaagca 894781 aaactgactc tttgaaaaag atcccgatgt acataatgat aaacccaacg aaaaccaaac 894841 ttaacgcaaa tgttctgatt ttattaattt tgctggagta tttcgccatg tccatccccc 894901 tctgttttaa ctatagcaca aacccgatgg gattttcttc atgttttcgg ttgaactgga 894961 atttacatat ggagagttac tgtgaaattg tttataatag ttcaatgtgt ttagaaaaaa 895021 ggaatttcgt tttaaccata gaattgaatc aaatagagaa taaaaaaatt tgaacaattg 895081 cattggagga atagtgatgg aaaatcttct ccgtccaatt taccaagaaa gagcaagtca 895141 ccccaataca ttggctgtca ttatgattga gagaagaaac aaaacatctt ccttaacaga 895201 taactttgat gcagctttgc tggtgattgt aaaggatgct gatgagccag tttttataaa 895261 gcattatgaa tttgatcatc aaacagcttc tttgcatgtg gtaacagatt ctcagattca 895321 agaatggatt ttgcttggaa caaatagaag aatcatagat tggattgtaa atggcagagt 895381 cttgtttgac cgtaatgaat acgtagttga actgattgac aggctgaata catttccgtt 895441 tgccgaacgt aaactgaaga tcggactcga atacggcaaa ttaatcagaa ggtatgttga 895501 agggaaagct ttttttgaag ccaatcaatt tttagatgcc tacaatgccg ttgttcatgc 895561 gctgcatcat ttagcacgta ttgaagtaat cgacagagga ttccatcccg aaaccacggt 895621 gtggagccaa gtgcgccaga tggagcccca agtgtacaaa ttatattccg agctgattga 895681 aagtcatgag agcctggaaa aaagacttga attattattc ttagcaaatg attttctcat 895741 ccattccaaa gccgagatcg gttcggcgca tcttttcgaa gtaatgaaag aaaaagacat 895801 ttggcaattc ggtgagcttc ttcaacatca tgacctaaag cactttaccc aagatcttgg 895861 cgttatgctt gattacttga cggaaaaggg acttatcaac gtctgccaga tagaaacgaa 895921 aggacaggct gtctatcacc gaggatattc ttttaaaaaa ggtgttgact ctgattcttg 895981 accgtgttat attattaaac gtcgctgatg cgcttctgag aaaacaagct cacagcggcg 896041 ggaaaataaa tcaaaaaaac atttgacaaa agaaagtcaa aatgttatat taataaagtc 896101 gcttcaacaa gaagtgaaaa tgatctttga aaactaaaca agacaaaacg tacctgttaa 896161 ttcagttttt aaaaaatcgc acagcgatgt gcgtagtcag tcaaactagg gcctgcacga 896221 cgcaggtcac acaggtgtcg ccgcaggatg cggtgaactt aacctgtgat ccatttatcg 896281 gagagtttga tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag 896341 cggacagatg ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta 896401 acctgcctgt aagactggga taactccggg aaaccggggc taataccgga tggttgtttg 896461 aaccgcatgg ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc 896521 gcattagcta gttggtgagg taacggctca ccaaggcaac gatgcgtagc cgacctgaga 896581 gggtgatcgg ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag 896641 ggaatcttcc gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt 896701 tcggatcgta aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct 896761 tgacggtacc taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta 896821 ggtggcaagc gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc 896881 tgatgtgaaa gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc 896941 agaagaggag agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac 897001 cagtggcgaa ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc 897061 gaacaggatt agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg 897121 gtttccgccc cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg 897181 caagactgaa actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta 897241 attcgaagca acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata 897301 ggacgtcccc ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt 897361 gagatgttgg gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag 897421 ttgggcactc taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat 897481 catcatgccc cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc 897541 gaaaccgcga ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa 897601 ctcgactgcg tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg 897661 ttcccgggcc ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg 897721 tgaggtaacc ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt 897781 aacaaggtag ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg 897841 gaatataaga ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga 897901 tcattccttc gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaattag 897961 taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg gcgcacggtg 898021 gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc ttcggggagc 898081 tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc gtaatggagt 898141 ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact gaaacatcta 898201 agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc gaaacgggat 898261 tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg gagttacaaa 898321 agaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca gccctgtagt 898381 caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga aattccgtcg 898441 gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata gtgaaccagt 898501 accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc tgaaaccgtg 898561 tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta gaatgaaccg 898621 gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg aaagcgagtc 898681 tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta cccatgtcca 898741 gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga aaagtgcggg 898801 gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg ttctctccga 898861 aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg attggactag 898921 gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact tatccttggg 898981 agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga ccgccagcta 899041 aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca accaggatgt 899101 tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg agtgactctg 899161 cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc ttcgaacagt 899221 ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg agcgcttaga 899281 agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac cgaatgccta 899341 aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc gaggccgaaa 899401 ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca tttgagcaat 899461 ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca agcagttagg 899521 ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag cgaaatatag 899581 tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga gaggtgcccg 899641 taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag agaactctcg 899701 ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct gttagggtgc 899761 aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa cacaggtctc 899821 tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga aggttaagag 899881 gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg ccgtaactat 899941 aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac gaaaggcgca 900001 acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg tgaagatgca 900061 ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg atattgaatg 900121 ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca gcttcggtgg 900181 aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc ccttatcggg 900241 cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa aaggtaacgg 900301 aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta aaggcacaag 900361 ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt agtgatccgg 900421 tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg ataacaggct 900481 tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc ggctcatcgc 900541 atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag cggtacgcga 900601 gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg caggaaattt 900661 gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt gtaccagttg 900721 ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg aaagcatcta 900781 agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag atccctgaaa 900841 gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct gacagatact 900901 aatcgatcga gggcttaacc atatttttga atgatgtcac acctgttatc tagttttgag 900961 agaataagtt tttcaaaaaa acacttgatt ttctcaagaa tacatagtat aatgttaaat 901021 gtcactgaaa ttgtctggtg atgatggcga agaggtcaca cccgttccca tgccgaacac 901081 ggaagttaag ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggaca 901141 tcgccaggca gacttcattc cgcagtagct cagtggtaga gctatcggct gttaaccgat 901201 cggtcgtagg ttcgaatcct acctgcggag ccattattgg agagctgtcc gagtggtcga 901261 aggagcacga ttggaaatcg tgtaggcggt caactccgtc tcaagggttc gaatcccttg 901321 ctctccgcca ctgatactta tacataatta caattgaaag tctgggcccg ttggtcaagc 901381 ggttaagaca ccgccctttc acggcggtaa cacgggttcg aatcccgtac gggtcattat 901441 atgatggagg attagctcag ctgggagagc atctgcctta caagcagagg gtcggcggtt 901501 cgagcccgtc atcctccacc attatatcat cgcggggtgg agcagttcgg tagctcgtcg 901561 ggctcataac ccgaaggtcg caggttcaaa tcctgccccc gcaaccaaat tttaaaatgg 901621 tccggtagtt cagttggtta gaatgcctgc ctgtcacgca ggaggtcgcg ggttcgagtc 901681 ccgtccggac cgccatttga atacttaggc tcggtagctc agttggtaga gcaacggact 901741 gaaaatccgt gtgtcggcgg ttcgattccg tcccgagcca ccacctatgc cggtgtagct 901801 caattggtag agcaactgac ttgtaatcag taggttgggg gttcaagtcc tcttgccggc 901861 actgtttttt caaaatttaa tgtggagggg tagcgaagtg gctaaacgcg gcggactgta 901921 aatccgctcc ctcagggttc ggcagttcga atctgccccc ctccaccatt tataggggca 901981 tagtttaacg gtagaacaga ggtctccaaa acctccggtg tgggttcgat tcctactgcc 902041 cctgccaaat ttatgacatc ttgagattat ggcggttgtg gcgaagtggt taacgcacca 902101 gattgtggct ctggcactcg tgggttcgat tcccatcaat cgccccatat tatcattggg 902161 ctatagccaa gcggtaaggc aacggacttt gactccgtca tgcgttggtt cgaatccagc 902221 tagcccagtc tcacttttta tatcaactgc atataatgta ttaagtccat taaaaatgcg 902281 gaagtagttc agtggtagaa caccaccttg ccaaggtggg ggtcgcgggt tcgaatcccg 902341 tcttccgctc caattacggc ggcatagcca agtggtaagg cagaggtctg caaaaccttt 902401 atccccggtt cgaatccggg tgtcgccttc ttattgccgg ggtggtggaa ttggcagaca 902461 cacaggactt aaaatcctgc ggtaggtgac taccgtgccg gttcaagtcc ggccctcggc 902521 accaatttta cttacatggt aagttgaatt ggtgtttgtg ttttatcatt ataactaatc 902581 atattaatga tctacataag tagatcattt ttttaatgct ttgatttatc ataacaagtt 902641 aagttccgag gcctattata aagcggctgt atagctagtc tttcaacact tttattttat 902701 atttccataa aaactttttt gaaatacgtt gacactttat gagatccatg atatatttat 902761 attcgtcggt tagatacgac gtaaaacttg ccggtgtggc ggaattggca gacgcgcacg 902821 actcaaaatc gtgttccttc tggagtgtcg gttcgacccc gaccaccggt atactgaaaa 902881 acccgtttct taacagaaac gggtttttat tttttattaa agaaaaggag cctcggctcc 902941 tttttatact tactcagcgt attggtctag gatctcttct agcacctctt ctagctcttc 903001 tgtatcttca agctctgatt ggctgaaacg gacgcgtaca agctgttctc cgtcattata 903061 catctcttcc aaccaccctc ggagtcctct tgctctgcgg tcgacttcga aaatgatttc 903121 caaaccgtct tcgtctaaaa ggaaaatgag ctctaattca tcaagcatct gacgataata 903181 tccggaagtc ggaacgaatt cgaattcttg aacgaacgga agacgacgct ggaagtaggg 903241 cgcttgttcg cagtctgctt cgttaagacg gaagcccagg ttttcgattg cttcaagcac 903301 attttcaatc caagggtgcg cttcaacgaa aatgcggtca tgatcggatt tatcgatacc 903361 gccttgaatg tcaaggtctg tcaccacggc aacctctact ttccctacag tgatcggcgt 903421 atctagaggc agagtgaatg tgaacggaaa ttgatgctct tcaccaggct gtatggtaaa 903481 tgaaccagtg acccggaaag aatgaattgt agcgtatttc cggtgctctt catcgtcttt 903541 tacaatgaca taccgtgtgc taagctgtaa atcgatataa cggatgtcct gagcgatttt 903601 tccgcctttg acatgtaccg ttccctgtac ttcttctcct ggaaaatatg cgtctttttc 903661 taaaattgta tctacttttg cagctccaat tccggcactt gccgcaagct tcttaaaaaa 903721 tgacatgtta gatcttcccc tttttctttt ttctcaacag atatacgtaa gaaggaggaa 903781 aaaagattcg tttgattcat acttttttcc tattattcgt ctcggcctag ggacagacta 903841 agaataatat tgaaaataaa ggagtcgatg gaagtgaata aagaaagttt ggttgcagat 903901 gaattacaca gaatgttttt ggctggtgag ctgcaaatca cagtagagga ggatataaac 903961 aatatttccg aaaggctgag aaacggcgat ctcagtttag accgattaag cggtgaagac 904021 gtgtttataa aagaaacggt aaatgaggct ttaagaagag tggagcaata aaaaagagac 904081 ggcatctcat ctttgagatc ccgtctcttt ttgtggtctt tgctgtaaga taaaagcgaa 904141 tcgatttgga attgctcacc cgagccaccc cttttctaac agaagatctg acagttcatc 904201 atggagataa acagctgtat ctaattgatc atgcaatgct cttctgatgt ggggattttc 904261 ggttgctgtt gttgcgacag tgtatttgtt aatgctggtt tttattgttg ttaacaaatc 904321 aagaatatct ttgggacaaa gactttgttc aatgggaaac cacctccttt gtttttttag 904381 cagctcctga taagaaagta tttgactttg tttcttgctt ctatacaaaa tgctataata 904441 agcaacaaat tttgttgggg ggtgtgatga tgaagcagat tattgcgatg gggggcgggg 904501 gtttttcgat ggagccggat aatttgtccc tcgatcaata tatcctcaat caatcaaaac 904561 gagagcagcc tcgtatttgt tttttgccga cggcgagcgg agattcccaa aactatattc 904621 agcggtttta tcatgcattt caaacattgg attgcgtgcc gtctcattta tctttgttta 904681 agccaccatc atcagattta gtttcttttg ttatggaaat ggacgtgatt tatgttggcg 904741 ggggaaatac gcggaattta cttgtgttat ggaaagagtg ggggctggac catattctca 904801 gggaagcatg gaagaacggt gtggttgtag ctggaataag tgccggtgcg atctgctggt 904861 ttgaagaagg ggtgacagat tcagccggac cgctgacaag tttgaaaagt ttaggttttt 904921 tgcaagggag cttttgtccc cattatgacg gggaaaagga tcggagaccg gcataccacc 904981 agctgatatc taacaagttc ttatgcagtg gctatgcagc ggatgatggg gctgctctcc 905041 atttcataaa tgatcagctg tttcagactg tgagttcaag gtcgggtgca aaggcatatc 905101 gggtgatgat ggctgaacat gaaatagctg aaatcccgtt gccggtcaaa tatttagggt 905161 gaaattggct gaatattatc tatattcctc tttttttcag attgatttta tgataagatg 905221 agtgcgaaat caatagttac tgggggtgcc cgctttcggg ctgagagaga aggcaagctt 905281 cttaaccctt tggacctgat ctggttcgta ccagcgtggg gaagtagagg aattgttttt 905341 gttattgtct tgctgggcaa taatatgttt ctttctgact gtaaccgggt tcatttatat 905401 gaatccggtt ttttgtgctg gttatgggct tgattttgtc ctttcaaacg tagaaagggg 905461 aaggaaaagt aatgcaaaac aattcagtgc agcaagccaa catttccatt atgtcaagtt 905521 tttcaggcag caagaaggta tacgtggagg gttcttcttc ggacatccaa gtgccgatga 905581 gggagattgc attgagtccg acgacgggat cgttcggcga agaggaaaac gcgcctgtgc 905641 gtgtctatga tacaagcgga ccgtatacgg accctgaagt aaccattaat attcaagaag 905701 gattaaagcc gctccgccaa aaatggatca cagagcgcgg tgacgtggaa gagtatgaag 905761 gtcgggctat aaaaccagaa gataacggtt ataaaaaagc aaaaccaaac gtaagctatc 905821 caggattaaa gcggaaaccg ctgagggcga aggcaggtca aaatgtcaca caaatgcact 905881 atgcaaaaaa ggggatcatt acacctgaga tggaatttat cgccattcgt gagcatgtgt 905941 ctcctgaatt cgtcagagac gaggtagcca gcggccgggc gattattcct tcaaacatta 906001 atcaccctga aagtgagcca atgattatcg gccggaattt tcatgtgaag attaatgcaa 906061 atatcgggaa ttcagcggtt acgtcatcca ttgaagaaga agtggaaaaa atgacgtggg 906121 ccatccgctg gggagcggat acgatgatgg atctctctac cggaaaagat attcatacga 906181 cgcgtgaatg gattatccgc aattgccccg tgcctgtggg aactgttccg atttatcagg 906241 cgcttgaaaa agtaaacggc gtagctgagg atttaacgtg ggagatttat cgtgatacgc 906301 taatcgagca ggcagagcag ggagtggatt attttacgat tcacgcgggt gttttgctta 906361 ggtatgtacc gctgactgcc aaacggacaa ctggtatcgt gtcacgcggg ggagcgatta 906421 tggcgcagtg gtgtctggct catcatcaag aaagcttttt atacacacat tttgaagaaa 906481 tatgtgagat tatgaaaatg tatgatattg ctttctctct tggggatggt ttgcgtcccg 906541 gatcaattgc tgatgccaat gacgaagcgc agtttgctga attagagacg cttggagagc 906601 tgacgcaaat tgcctggaag catgatgttc aggtgatgat tgagggtcct ggacatgttc 906661 cgatgcataa aatcaaagag aacgtcgata aacaaatgga catttgtaaa gaagcgcctt 906721 tttacacatt ggggccgttg acaacggata ttgctccggg atatgaccat attacttcag 906781 cgatcggagc ggcgatgatc ggttggtacg ggacagcaat gctttgttat gtaacgccga 906841 aggagcattt ggggctgcca aaccgtgatg atgttcgtga aggagtcatt acatataaga 906901 tcgctgcgca cgctgcggac cttgcaaaag ggcatcccgg agcgcaaatc cgggatgatg 906961 cgttatcgaa agcccgtttt gaattccgct ggcgggatca gtttaattta tctcttgatc 907021 cggagagagc ccttgaatac catgatgaaa ccctgcctgc tgaaggagca aaaaccgctc 907081 acttttgttc catgtgcggt ccgaaatttt gcagcatgag aatttcacag gatattcggg 907141 attatgcgaa gaaaaacgat ctcagtgaag cagaagccat aaataaagga ttaaaagaaa 907201 aagcaaaaga gtttgtcgat acgggaagca atttatatca ataaaaaaaa tgaagatgga 907261 gaatgctcca tcttcatttt tttagaaaaa cagagagcgt cgaagcggag gaatactctg 907321 ttcaaagcgg aaaacatttt ctggatcata tgtcgttttg acacggcgga gtcgttcaac 907381 gttttcgccg taatatgttc ttggccagtt tctgatttcg atatctggcc aatttacgta 907441 gtctcccatc gtttctttcg aaagggacgt tctcagcccc tcaatccagc ggacattttg 907501 tcttttttct ccaggggatg tccagtttgt taagtattcc tgggcgatga ttgcgtcacg 907561 ataataaaat gccgtttggt cgggagcgac ccgtccggct gccccgccga gtgcttgctg 907621 ccagacactg gcgttttgat tcggagcgtg ctctaaaaag tgttttattg ttgagatcgc 907681 acgttctgat aatggctttt caatgaaaga gccggagcgt ttcatttttt gaggctgatt 907741 gcctcccggg ctgttaaaaa aggttaccgc ttcaatgaat ggcgttgttt ttaccattcc 907801 gcttgtcgga cttcctgctt tcaataaagg ctttaacagt ttttttaact ctgtttttgg 907861 cccgacaaat tggccgaggg cttctatgcg gtttacttct ttaggccaaa actctattga 907921 tgatgtaagc cggtcatctg tatacggggc ccagttctgc cacgtgttat atacttcctc 907981 aaaatcatcc catccccatg taatagaaaa aatcgacact tgagagatgg gcactgcttt 908041 aaatgtcatg gaggtgacta tgccgaaatt gcctcctccg cctccctgag acgcccaaaa 908101 taagtctgga tgatttgaac agctgactgt aatcagatca gcgccctctt tttcgtctgc 908161 tacgatcatc tcaagctgca cgaggctgtc gcaagtaaga ccggcagccc ttgttaaaag 908221 tccaattccc cctccgagag ttaaacctgt gagccctaca ttagcaatgg tgcctgcggg 908281 aagcgtcagg ccgtattgcc agagtgtccg atagacttct cccaattcag cccccgcttc 908341 aatataggcc agctttttat cctgattcac agttattttt ttcatctcgc ttaaatcaat 908401 aacaagaccg ttatttaaaa gggaaaagtt ctcatagctg tgtctgccgc ctctaatacg 908461 gaaaggcaca cggttttcac gcgcccattt cagcgcattg agtgcatcct gtttgttttg 908521 gcaaaacaca atgatgtcag gatacctttc taagcttagg ttaatattgg ttcttgcttc 908581 gttatagtcc ggatcatccc gtgtcacgat acgtccggtc aattttgtct tttccacact 908641 cccacatctc tttctctcgt attctagttt ctctagctta tgcgtcaggg gaaaagagtg 908701 tataaggaaa aagcggggat gcaatctgat acagtgtcaa caccctcaaa aaatagttga 908761 caggtcggta ttgtatgaat taacatggtc agtacaaatt tttcaaattt atcgcgctga 908821 tcggaacacc gaaggctctt atcgtttaga taagggcctt ttttgtatga aaaagggggg 908881 attattgatg ggagtcaaaa aagaaaaggg gagaaaacga ttcaggaagc gaaaaaccta 908941 cgggaatcag attttgccgc ttgagctgct gattgaaaaa aacaaacgag agattataaa 909001 cagcgcggaa ctcatggaag aaatttatat gaagattgat gagaagcata cgcaatgtgt 909061 aactaaatat aaaaaaaccc gctgactaca acgggttttt gcatttctcc attaagaatc 909121 ttttttaatc ggcaatccaa ggccttctgc cacgcgtttt ccgtattcag gatccgcttt 909181 gtagaagtgc tcgatttggc gcagcttgat ttcttctttt tctaccggct tcatggcatt 909241 aacgatattt tcaacaaggc gggtacgttc atcttcactc attaaacgat acagatcgcc 909301 ggcttgagtg tagtgatcgt agtgatcgta gcttacgctg tcagcgatac cttgtaccgg 909361 atatgctgct tgcttatcct caggtgactc ttttggaccg ccgaagctgt taggctcgta 909421 atacacagat ccgccgccgt tatcatcaaa acgcatttgc ccatcacgct gataattgtt 909481 tactttgttg cgtgcgcggt tgattggcag cgcttgatgg tttgcaccga cacggtagcg 909541 gtgtgcatca tgataagcaa aaagtcgacc ttgaagcatt ttatccggtg aaacatcaat 909601 accaggcacg agggttccag gtgaaaatgt cgcttgttct acctctgcaa agtagttttc 909661 cggatttctg tctagaacca tgcgtccgac ctcgattaac gggtagtctt tttgagacca 909721 aacttttgtg acatcaaacg gatcgaaacg gtacgtattt gcatcttcta aaggcatgat 909781 ttgcacatat agtttccatg caggataatc accgttttcg attgcgttga aaaggtcttc 909841 tgtatggtaa tcagggtttt caccggcaat ttttgctgcc gtattgacat caaggttttt 909901 cacgccttgt tctgttttaa agtgatattt aatccatacg ccttcgcctt cggcatttgt 909961 ccatttgaat gtatggcttc cgaagccgtg catgtggcga agtgtcgcag gaattccgcg 910021 gtcagacatc aggattgtca cttggtgcag tgactctggt gaaagtgacc agaaatccca 910081 tacagccgta gggtttttca ggtgtgtttt tggatctctt ttttgtgtat ggatgaaatc 910141 agggaactta atcgcatcgc ggataaagaa tacaggcgta ttgttgccga cgatgtcgta 910201 gtttccttct tcagtataaa atttaacagc aaatccgcgc gggtcgcgaa ctgtgtcagc 910261 agagccaagt tcaccggcaa ctgttgagaa acggatgaac aacggtgtgc gtttgccgac 910321 ttcagaaagg aaagcggctt tcgtgtattt tgttacgtcg tttgtcactt caaaatatcc 910381 gtgtgcgcct gctcctttgg cgtgaacaac acgttcagga acacgttctc ggttgaaatg 910441 ggccaatttt tcgagtaaat gtacatcttg aattaaagtt ggtccgcgag aaccggcagt 910501 cattgagttt tgattatctc caaccggagc gccccagcta gttgtcagtt tatttgaact 910561 catgttatca cctcttggaa tttataagaa cataatatca tctctaagta aaaagtcaat 910621 attattttat aattattata aaatagttat ctctattaat cgatatatag tatcgaaatt 910681 gttgaaaaac cttgttgtaa cagcttttta tgacacttaa taatttttgg agaaataatt 910741 tttccttctc tatttgcgaa acaagcagag taagtgataa acaaggatat caaaaatcgt 910801 atttaaaaaa gagttgacat atcggaataa tttgaattaa catgttattc aaacaaaaaa 910861 acaattgggc agctgatcgg accgccgaag gctctcatct ctacaagaac agagatgggg 910921 gcctttttgt tttttttgaa ggcggggttg gcagaaagag agggataaaa gtggctgtga 910981 ccatcagcat caaagaaaag gcatttgttc aagaaggccg caaaaacacg gtcttagaaa 911041 acatagaatt atcaatcgca ccaggcgaat ttctaacgct tatcggaccg agcgggtgcg 911101 gaaaaagcac cctgttaaag attattgcag ggcttgattc tgaatatgac gggagtgtgg 911161 aaattaacgg ccgcagcgta acagctccgg gtattcagca aggatttatt tttcaggaac 911221 accgcctctt tccttggctg actgttgagc agaatattgc agccgacttg aatttgaagg 911281 acccaaaagt caaacaaaag gtggatgaac tgatcgagat tgtcagattg aaaggatcgg 911341 aaaaagcata tccgcgcgag ctgtcaggcg gcatgtcaca aagagtagcc atcgcccggg 911401 ccctgctgcg ggagcctgag gtgctgcttt tagatgaacc gtttggtgca ctcgacgctt 911461 ttacaagaaa acacctgcag gacgtgctgc tggatatatg gaggaagaaa aaaacaacga 911521 tgattctcgt gactcatgat atagatgaat ctgtttattt aggaaatgag cttgcgatcc 911581 ttaaggccaa accggggaaa atccataagc tgatgcccat tcacctggcg tatccgcgaa 911641 accggacgac tccggatttc caagcgatca gacagagagt gctgtcggaa ttcgagaaaa 911701 cagaagattt ggagtacgca gaaggatcag ggatatagaa agggcggaag cggaaatgaa 911761 aaaaggactc attgtattgg ttgccgttat ttttctgctc gcaggctgtg gagcaaatgg 911821 agccagcggt gaccacaaac aattgaagga aattcgtatt ggtattcagc aaagcttaag 911881 cccccttttg attgcaaaag aaaaaggctg gttcgaagat gcatttgaaa aagaaggcat 911941 caaagtgaaa tgggtggagt ttcaaagcgg tccgccccaa tttgaaggcc ttgcggcaga 912001 caaacttgat ttttctcaag tcggtaattc gcctgtgatc gctggacagg cggcaggcat 912061 tgactttaaa gaaatcggtt tgtctcagga cggcttgaaa gcaaacggca tccttgtcaa 912121 tcaaaacagc ggcattcaag acgttaaggg cttaaagggg aagaaaattg cagtcgccaa 912181 aggcagcagc gggtttgatt ttttgtataa agcgcttgat caagtggggt tgtcagctaa 912241 cgatgtgaca attattcagc ttcagcctga tgaagcagct tccgcatttg aaaacggatc 912301 tgttgatgcc tggtccattt gggagccgta cttgtcctta gaaacaatga aacacggagc 912361 aaaaatcctt gtgaacggag aaagcacaga tttatattca ccgggtttta ctttagtaag 912421 aacaaagttt tcagaagagc atccagacga agtggtccgt tttctgaagg tgtttaataa 912481 agccgttgta tggcaaaagg aacatctgga tgaagcagcg gacttatatt ctgacattaa 912541 agatctcgat aaaaaggtcg tcgaaaatgt gctgaaaaat actgagccac ttaatgagat 912601 catcagtgac gacattgtga aagcacagca ggaaacagca gattttcaat ttcgaacaaa 912661 ggcgatagat aagaagattg atgtgaagga tgttgtcgat aacactttta tcaaaaaagc 912721 attagaggag cattcctcag gaggtgatca atgatgaaag cagaggctgc gggctcgctg 912781 cccaaaacga atgcggaagc ggtgcgaaaa aagcccggaa ggaagagata cggctggatg 912841 aaggggcttt tactgcccgc tgtcatcatt gccatctggc aggtcatcgg cgggctgggg 912901 gttgtgtccg ctacagtgct gcctacacct gttacgattg ttctgacctt taaggagctt 912961 attttgtccg gcgaactgtt cggccatctg caaatcagca tttatcgggc ggcacttggt 913021 tttttgcttg gcgcggggct tggattgatg atcgggattt tggccggatt ttccaaacgg 913081 acggagctgt atcttgatcc gtcgttgcaa atgcttagaa ccgtacctca tctggccgtc 913141 acgccgctgt ttattttatg gttcggattt gacgaagtat ctaaaatttt gctgattgcg 913201 ctcggtgcct tctttcctgt ctatatcaat acgtttaacg gcatccgcgg ggttgacgcg 913261 aagctgtttg aagtcgcccg ggtgcttgaa tttaaatggc atcagcagat atccaaagtg 913321 atattgccgg cagccctgcc caatatattg ctaggcattc gcttatcgct cggcattgca 913381 tggctcgggc tcgttgtggc agagctgatg ggctcaagct cgggagtcgg ctatatgatc 913441 atggatgcga gacagttttc acaaacgaat aaagtctttg cagggattat catttttgca 913501 gtggttggaa agctgacgga ttccttcgtc aggctgcttg aacgaaagct gttaaagtgg 913561 agaaacagct acgaaggata aaagatataa aggggagatg aatatggaaa ttctttggtt 913621 tataccgact catggagacg cgagatattt aggatctgaa agtgatggac ggactgcgga 913681 tcatctttac tttaaacaag tcgcgcaggc ggcagacagg ctgggatata caggagttct 913741 tctgccaacg ggaagatcgt gcgaggaccc gtggcttaca gcgtcggcac tggcaggaga 913801 aacaaaggac ttaaagtttt tagtcgcggt aagacctggt ttaatgcagc cttctctggc 913861 agccagaatg acatccaccc tagaccgcat ttcagacggc cggctgctga tcaacgttgt 913921 ggcagggggc gatccgtatg agctggcagg cgatggcctg tttatcagcc atgatgagcg 913981 ctacgaggca acagacgaat ttttaaccgt ttggcggaga cttttgcagg gagaaacggt 914041 ttcctatgaa ggaaagcata taaaagtgga aaacagcaat ctgcttttcc cgccgcagca 914101 agagccgcat ccgcccatct atttcggtgg ttcgtcacag gctggaattg aagctgccgc 914161 aaagcataca gacgtgtact tgacatgggg tgagccgcct gaacaagtaa aagaaaagat 914221 agaaagagtc aaaaagcaag cggcaaaaga agggagatcc gttcgatttg gcattaggct 914281 gcatgtcatt gcccgtgaaa ctgaacaaga ggcatgggaa gcggcagagc gcttgatcag 914341 ccacttggat gatgacacca ttgccaaagc gcaggcagct ttgagccgtt acgactcttc 914401 aggccagcag cggatggccg tccttcatca aggcgatcgg acgaagcttg aaatcagccc 914461 gaatctgtgg gcggggatcg gcctggtcag aggaggggca ggaacagctc ttgtcggtga 914521 tccgcagacg attgccgacc ggatagcgga gtaccaggca ctcggcatag aatcgtttat 914581 attctccggc tatccgcatt tagaagaagc gtattatttt gcagagcttg tatttccgct 914641 tttgccgttt gaaaatgatc ggacgagaaa gcttcagaac aaaaggggag aagcggtagg 914701 aaacacttat tttgtcaaag agaaaaatgc atgagtttaa ctaaaataca gccccccgaa 914761 catggtatga tattcaaaaa aagggggctt tttttctgaa aacattgaga agcgcggcag 914821 tcatttgcct catagctatg ctgtcagcat gcggacattc aaaacagatg gaaatcaaag 914881 cggcggacat atcagatctt gaaaaaaaca gaatggatgt cgcagcttca caggcattca 914941 ctgccgaagc cgtcaatatc ggtgaaggta tttcttcagc tgacatgtac atcgaacatt 915001 atcaaaaggg aaagcttgtt gagaggtttg gaccggttcg tgcagattat tcagaggaaa 915061 aaactgatac catacaattt gtttattttg agaatgaaga gggggaagga aagaataaac 915121 ataccaccat tcattttggc attgtggata aacagggaac tatagcggct gattcatcgg 915181 tgaaacgcga cgatagcaca acacaggaaa tgactcagaa tatttcatcg ccggaaccga 915241 ttactttcga gaagcctgct ttgatcggca gcagtattag agggactgac gagacaatgc 915301 acacctctga acataaaaaa gagctcatta agcatcaaga tgcgttactg tattatgtgg 915361 aattgcatca ttagaatggg cggcttcagg ccgtctgttt tacaaagcgg tatgcttgct 915421 tttttgaatg gtgaatgata cattttaaat cgtaacaatt tcgatttaaa gggaggctat 915481 gtgacttggc taaaaaatca aaagtggcaa aagagttaaa acgccaacag cttgttgagc 915541 aatacgctgg tattagacgc gagttgaagg aaaaaggaga ttacgaggca ctcagcaagc 915601 tgccaagaga ttcagcaccg ggaaggcttc acaaccgctg catggtaacg gggcgcccga 915661 gagcatatat gaggaagttt aaaatgtcca gaatcgcttt cagggagctg gcccataaag 915721 gccagattcc cggtgtgaaa aaagcaagct ggtaagaaaa aactccggcc gattacagcg 915781 cgccggagtt tttttcgttt ttcttgaaag agatgacgta ggaaaggtgc tggatgatca 915841 tgatgataaa cacaataata atagggaaaa acggaatgcg cgattgaaat agcggataaa 915901 aaatgagaag aaccgctgcg gcaggcagcg agaagtagac agcgatatat gacgcgcgac 915961 atgcttttgc cgtcatcatc tgctctcttt catcctgctc ttcaaactca tcaggcagaa 916021 gtagctgctt tctggcaggg cggctttttt tctgtaagta caaataaacc gcagacgccg 916081 caacaaacag aataaaggga gtgaggttta aatcaaatac catcccgccg ctctttgtgc 916141 cgaaaaaaga tgctatgcct tctgaggctt caaagtatga aatcagcgcc cagcatgcaa 916201 ggccaaataa aacaaggtga aaagctgctt ttgttttcat gctcatctta gttttcctcc 916261 tctaaccaaa agacatcctc cattttcatg gagaaggctt tgcagatttt cagtgctaac 916321 agcagtgagg gaacataatc gcctttttca atcgctgcca cagtctgtct tgtgacgccg 916381 accgtttctc cgagtttttc ctgagaatag ccgaagcgtg ccctcagctc ttttacttta 916441 tttttcatca tgacgtctgt ccccttcaca atctcgattg attatattgt atagtatact 916501 taacattatg taaatggaac ttaacaactt tacaaaaaga taactttttt tcgacaaaat 916561 ttttatattc ccttgacgaa aaataaataa acatgtaata taaaaaaagt cagagcggta 916621 ctgttgctga caatcacaaa tgcgggtgta gtttagtggt aaaacctcag ccttccaagc 916681 tgatgtcgtg agttcgattc tcatcacccg ctccatacat acgttattaa cgcagtgttt 916741 cgtttctcag ataaacgaag tattgcgttt ttttatgtga aaaagaacac ggtattcgtg 916801 ttcttttacg taagccaatg tactgtatgg gtgccgccgt gaatttgttc aaacattttc 916861 gttaatgatg ataagaggtt aacagcgctg cttttctcaa tcgatggcgg gaaaaaaatg 916921 atttgcagca tattcttagt ctcgtttgaa acgggatagt ggttgacgct gtttttgaaa 916981 tcgccaaaaa tgccgttttc atcagagaaa agcagtatgt tttctttttc tcccaatgag 917041 atccggaccg gctcatgaag ctttccggca tcataaatca taataggcag agaatatttt 917101 aatgcgaaaa aatcgattgt gtcatgggcc gagtctttac tttccatgaa ttgttccttg 917161 gatatcggga ccagcatgtc ctccattggg gttgtttctc cctcaaatga agggttaagc 917221 tgtttaaaga gtttctgcca ttccttgacg aaggattcat cggatatacc gccgtccgca 917281 tagtcgaaaa acaaggattc ttgaaacagg cggagtctgc ctttcagcat ttgcggtgag 917341 gagccgactt cgatattctc ataaatgaca gcagctgcat gtaagccggc cgcacgttca 917401 gtaataacag aatcaagttt gatattcact agcattcact ccagttacgt gatatcaacc 917461 tattataaac gctgtgtcgt tttatcacaa agaaaggagg ctgtgcaaaa catgaacgtt 917521 tatcagctca aagaagaatt aattgaatac gcgaaaagca ttggcgtaga caagattggt 917581 tttacgaccg ctgatacttt tgacagttta aaagaccgtt tgattcttca agaatcactc 917641 ggctatctct ccggctttga agagccagat atcgaaaaaa gggtgacgcc gaagcttctt 917701 ttgccgaaag cgaaatcaat agtggcaatt gctctcgcat atccttccag aatgaaggat 917761 gcgccgagaa gcacgagaac tgagcgcagg ggcatttttt gcagagcttc ctggggaaaa 917821 gactatcatg atgtgctgag ggaaaagctt gatctgctgg aggattttct aaaaagcaag 917881 catgaggata tcagaacgaa gtcaatggtt gatacaggtg aattgtctga tcgcgccgtt 917941 gcggaacgtg ccggaatcgg attcagtgcg aaaaactgta tgatcacaac acccgagtat 918001 ggctcttatg tgtatttggc ggaaatgatc acaaatatcc cttttgagcc tgatgtgccg 918061 attgaagata tgtgcgggtc ctgcacgaaa tgcttggacg cctgcccaac gggagcactg 918121 gttaatcccg ggcagcttaa tgcgcagcgc tgcatctctt ttctgaccca gacaaaagga 918181 tttttgcctg atgaattccg gacaaaaatc ggaaaccgcc tgtacgggtg cgatacgtgc 918241 caaacggtat gccctctcaa taaagggaag gattttcatc ttcatccgga aatggagcct 918301 gatcctgaga ttgccaaacc gttattgaag ccgcttttgg ccatcagcaa tcgggaattt 918361 aaggagaaat tcgggcatgt ctcaggttct tggcgcggaa aaaaaccgat tcagcgaaac 918421 gccattctcg cgcttgccca ttttaaggat gcttccgcac tgcctgaatt gacggaactg 918481 atgcacaagg atccgcgtcc tgtcatcagg gggacagccg catgggcaat cggaaaaatc 918541 ggagaccccg cctacgcgga agagcttgaa aaagcgctgg aaaaagagaa ggatgaagag 918601 gcaaagctgg aaattgaaaa aggaattgag ttgctaaaag cttcaggcat gactaaacaa 918661 ggcctgtcct gacatacgta tagagcagaa ggaaaaaaca cttgagatca tccaagtgtt 918721 ttttctctat aaaaaagtat ggcgggtggg gtgagcttga agtacatttt agaacaatta 918781 gcggaggagc ggctgggctt tctggttaac gggcatgcta tgagacagga gtctcaagtc 918841 ggagacctta aagtcatgga gcgtaagaaa aagcttctgg aaaaacgtaa agttgacatc 918901 ataaaagcga aagcaaaggc cgtgattaat catgtgcggg ttgaggatga cggaacgacc 918961 tgcctttcgt ataccatcca ttacgaatac gtgtgtaagg aacaagatga cagcttgtat 919021 atagaagagc acatagagga gcgaatggct ttcctgtatg atcacatttt gattagtgat 919081 caggaaattg cgaaaaagcc ggctggattt catgaaggga ccagtattat tgactattct 919141 gaagctgaag aggaaagaga agcgtttggc agggcttttc aatacgatcg tctcggcgct 919201 gtccaatatg ccgagaaatt ttggaacaag cgcaatcctg cttataaaaa tttcagcgat 919261 aactgtacaa attttatttc tcagtgtctt catgcaggag gcgcgccgat gcgcggtcat 919321 ccgaacaggg gatcaggctg gtggatgaaa caaagctcat ggagctacag ctggacggtg 919381 gctcactcta tgaaaatgta tttgtcgaat tcaaaggccg gactgcgtgc ggtgcgggtg 919441 aaatcagcgg aagaactgat gccgggcgat gtgatttgct atgacttcga aggagacggc 919501 cggtttaatc atacaacgat tgtcgtggca aaggacaaag gcaatatgcc gcttgtcaac 919561 gcccagactt atgacagcag gatgaggtat tggtcatatg aggattctac ggcatacacg 919621 ccgtcaatac gatatgcctt ttttcatatc gttgatgata cgacaaaaga gtaattaatg 919681 ttataatgat gggcggataa gaaaaacaga ggtgaacatt gtggcattac atgtcgtttt 919741 atatcaacca gaaattcccg ctaacacagg gaatattgca cgtacttgtg cagcaaccaa 919801 tacaacgcta cacctgattc gtccgctcgg cttttcaacg gatgataaaa tgctgaagcg 919861 tgccggactc gattattggg agtttgttaa cgttgtgtat catgattcgt tagaagaatt 919921 gtttgaggca tataaaaaag gcaagttttt ctttattaca aaatttggcc agcagcctca 919981 tacatcattt gattacactg atcttgacga ggattatttc ttcgtgttcg gaagagaaac 920041 aagcggtttg ccaaaggatt taattcaaaa taatatggac cgctgcctgc gtcttccgat 920101 gacagagcat gtcagatcgt taaatctgtc caatactgcc gcgattcttg tttatgaagc 920161 gctgcgccag caaaattacc gtgatttaaa atagtgaaaa acccgctcat cgatgatggg 920221 cgggtttttt tgcggatgtt gaaatgcttt gtttcgtttt tgggcttaac aacgtaacag 920281 tgttatgtta caatgtaccc atcaaaggag ctggacttat ggaagaacaa ttaatctcta 920341 aaaaagaatt acttgaaaga acatcgattt catacggtca gctgtatcga tggaagcgga 920401 aaaacttaat acctgaggaa tggtttattc gtaaatccac atttacaggg caagagacgt 920461 tttttccgag agaggagatt ttaaaacgta tatcaatgat tcaaaagatg aaagaaaatt 920521 tgtctttgga tgaaatgagg gaaatgctgt cgccgaaaat gaaggatgtc agcatgaccg 920581 ctgatgaatt gcttcataaa ggtttggttt caaggcctgc tcttgaagcc tattcagaag 920641 acggaggaag tccggttttt tcatccagcg atttgctttc gctgtttgtg cttgagggcc 920701 tgctgcagtc tggaaatgtc agccttgcag aagcaaaaat ggctgcagag gtattaaaga 920761 agcatgatac tgaagagatt gaaaaacaga cggagctgat tgtgctccgc aagctcggtg 920821 tcacaacttg ttttatagcg gctgcggcgg acagcatttt gtttgaatca tccgtaaagg 920881 ttgtggaacg ggtagattta ttaaaagctt cagaggaatt aaaaacaaca tttatgcagg 920941 agggccatca atggatgtag tggaaaagct ggtgataaat ggatcaggaa gttctaaggg 921001 aggaacattt caatcagttg agattaatgg cagcgggaca gtggccgggg acgtggagtg 921061 tgacactttt tcttttaatg gaaacggaaa agcggacggc agcgtcaaag cgaaagcggt 921121 aactatcagc ggttcaggaa agatacatgg agacgttgaa gcagaatcta tccggatgaa 921181 tggcactggt tttattcaag gagaggtatc tgcaaaacaa ttgaaaatcg ctggatcatc 921241 aacatttggc ggcactgtca aggctgatgg aattgacatt agcggaaaag ctgtcatgga 921301 agcagattgt gaaacagaaa cctttcaatc agaagggaaa tgcaaaatca gcgggctttt 921361 aaatgcagac caggtgatca ttaagctttc tgcaggggaa agctatgcgc gggagatcgg 921421 ctgccgccat cttcaagtga cctgcagaaa aggaatgctg acattgctca gattgatgcc 921481 gcagcctgtt ctaacagcag agctgatcga aggtgacgtg attgaattga caaatacaaa 921541 ggcgaaaacc gtgcgcggta ataaagtgat catcggcccg gattgccaga ttgaaaccgt 921601 cgaatacagc ggggactata cctgtgatcc aagcgcgtcg gttgaaacat ccacaaagtt 921661 gtaaggagga tcgtaatgga gacaacaaaa ctgggaaatt taaaattata tggcgctggg 921721 catgccgcag gaggcgcgta tcacaatgtc agcatcaaag gagaaggtat agttggagaa 921781 gggctgtctg ctgtaggctg ccgcatatac ggaacgggcc tttttctcgg aaaagcagag 921841 actgagcggc tgcgtgtgct cggagaaagt gaatgtaaag gcgatctgac agccggcaaa 921901 atcaatatat atgggacaat gaaagtcagc ggctcacttc aatttgatcg attcaatctg 921961 aaaggccaga ctgaaattgg cgggaatatg actggagaat cctgcgatgt gaaagggaag 922021 cttagcgtaa taggtgattg tgaaacagaa atgttccatg tcacaggctg tgttgatgta 922081 tcggggttat taaattcggg tgagatcaag ctgggattga gccatgatat aagccatgtg 922141 caggaaatcg gcggaacaac aattacagtg aaaagacgcg cgagtttttt tagccggaag 922201 aaagggaagc tgatcgccga tgtcatagaa ggagatcggg tttatttgga gaataccgaa 922261 gcggcagttg tcaggggaaa agaagtgatc atcgggccgg gatgcagcat cggaacgatt 922321 gagtacgaat acaaatgtga atgcgatccg cattcacaga ttaaagaaaa aacaaaactg 922381 taaaacattg ttctgttata caaaaagggt gctctttcag gagcaccctt ttttattctt 922441 ttccaggctt gctttcgtat cctgcggtaa aaattgatac taaaaaagtg acaatgacac 922501 ccatcatgat gattgttttc accgtctctc cccctcttca atttttccgt gctgtccgag 922561 tctggatgat tctgtatttt tctttattat gaacggtcgc agtctgcctt gtcaacgatg 922621 tatgagtatc tttattttta agaaaccaaa gcatgtatca cgagatggcg gcatagattg 922681 tatcaaagta ccttatttgc atagtgtatc aaacatgata gaggaggtcc ttatggatat 922741 attaaagaaa attgaaaagt acagagagga agagcagcgg ctgaaatggg aaggaacttt 922801 cgccgattat ttggagatta ttaaagaaaa tccgatggtc gcgcaatctg ctcattctcg 922861 agtttttaat atgataaaag acagcgggat agaggagatt gacggacgca agaagtacag 922921 tttttttgac cgcgagctgt tcgggcttga agaatctctg gagcgtcttg tggaagagta 922981 ttttcatccg gctgccaaac gtctagatgt cagaaagcgg attctattgc tgatggggcc 923041 tgtgagcggc ggtaaatcca cgctggtcac aatgcttaaa aaaggtctcg aagcgtacac 923101 gctgacagat aatggcgctg tatatgcgat taaaggctgc ccgatgcacg aggaccctct 923161 acatttaatc ccccatcatt tacgcgatga cttttacaga gaatacggca ttagaataga 923221 aggaagtctt tctcctttaa atgtcatgag gctggaggaa gagtacggag gaagaattga 923281 ggatgtgaag gtggagcgca tcttcttttc agaagataag cgtacgggaa ttggaacatt 923341 cagtccctct gatccgaaat ctcaggatat tgccgatttg acggggagta ttgatttctc 923401 aacaatcgcc gagtacggtt cagaatcaga tccgcgcgct tatcgatttg acggagagct 923461 gaataaagcg aaccgcggga tgatggagtt tcaggagatg ctgaaatgtg atgagaaatt 923521 tctctggcat ttgctttcct tgacacagga agggaatttt aaagctgggc ggtttgcgtt 923581 aatttctgct gatgagctga tcgtggctca cacgaatgaa acggagtatc gctcatttat 923641 ttctaataag aagaatgaag ccctgcactc aagaatcatc gtgatgccgg ttccttataa 923701 tttaaaagtg tctgaggaag agagaattta tgaaaaaatg attgcagaaa gcgatgtggc 923761 ggatgttcat attgccccgc atacgttgaa ggtcgccgcg atgttctcaa tccttacccg 923821 gttaaaagag ccgaagcggt cggatattga tctggtcaag aaaatgagac tgtatgatgg 923881 ggaaagtgtg gaaggatata actctgtcga cgttgaggat atgaaaaaag aatataatga 923941 tgaaggcatg agcggaattg atccgcggta cgtgatcaac cggatttctt caacgattat 924001 cagaaaaaat atggaatcga ttaattctct cgatgtcctt cgctccttaa aagaaggtct 924061 tgatcagcac ccatcaattt caagcgagga cagggagcgg tatttgaatt ttatctctgc 924121 cgcccgcaag gaatatgacg atattgcgaa aaaggaagtt caaaaagcgt ttgtttattc 924181 atatgaagaa tcagcaaaaa cacttatgga caattacctc gataacgtag aggcctattg 924241 caataaaaac aagcttcgtg atcctttgac aggagaggaa atgaaccctg acgaaaagct 924301 gatgagatcc atcgaagagc agatcggcat ttcggaaaac gccaaaaaag cgttccgcga 924361 agaaatttta atccgcatct cggcctatgc gagaaaaggc aagcggtttg attacaattc 924421 ccatgaaaga ctgcgtgaag ctattcagaa aaagctgttt gctgatctga aggatgtcgt 924481 taaaattacg acctcaacaa aaacgccgga tgagcagcag ctgaaaaagg taaatgaagt 924541 cgtggcccgt ttaattgatg agcacggcta caactcgacg agcgccaatg agctgctgaa 924601 atatgtcggc agcctgctga accgataagc aacgtgaccc gtccgaatag ggcgggttat 924661 tttgtcccat tttctaaata gtttgtcaat taaacgtgca tatgtgcata tgatgaatat 924721 aaatcttttc aaaagacttg tttcataatc tggcacaagc cggaatacgt atgtatcacg 924781 accacaaatg gttaaggagg ggaattcatg tcccaaaatg acagcggcca ttttttgatt 924841 tctgaggaaa actggtccct ccatcgcaaa ggcttcgatg accagcagcg ccaccagaaa 924901 aaagtgcagg aagcgatcaa aaacaatctt ccggacctcg taactgagga aagcattatt 924961 atgtctaatg gaaaagatgt agtgaagatc ccaatccgtt cacttgatga gtataaaatc 925021 cgttataact atgataaaaa taaacatgta gggcaaggag acggcgagag ccaggttgga 925081 gatgttgtgg cccgggatgg atcagacaaa aaacaagggc ctggaaaagg gcagggtgcc 925141 ggtgatcagg caggcgagga ttattatgaa gcggaagttt cattaatgga tttagaagaa 925201 gcgcttttta aagaattaga gcttccgaat ctccagcaaa aagagcggga caatatcatt 925261 catacagata tcgagtttaa tgatatccgt aaaacagggt taaccggtaa tattgataag 925321 aaaagaacga tgatgtcagc ctttaaacga aacgcaatgt caggaaaacc gtcgttctac 925381 ccaatttatc cggaggacct gaaatataag acgtggaatg acatcacaaa gcccgaatca 925441 aaagccgtcg ttttagccat gatggataca agcggcagta tgggggtttg ggaaaaatac 925501 atggccagaa gcttcttttt ctggatgacc cgttttttgc ggacaaaata cgagactgtg 925561 gaaattgaat ttattgccca tcatacagaa gcaagagtgg tctcggagga ggattttttc 925621 tcaaagggag aaagcggcgg aacaatttgt tcttccgtat atcggaagtc gcttgagctt 925681 attgatgaaa agtacaatcc cgcccgctat aacatttacc cgtttcattt ttctgacggt 925741 gacaacctga catctgataa cgcgcgctgt gtgaagctgg tcaatgatat tatgaagaag 925801 gccaatctgt tttgctacgg cgaggtcaat cagtacaaca ggcattcaac gttaatgtct 925861 gcatataaaa atgtaaaaga tgagaaattt aagtactata ttttaaaaca gaaatctgat 925921 gtttttcagg ctctaaagaa ctttttcaga aatgaagagt ctggtgtaag ccatcaattt 925981 tcgtaatgaa aagcccattt cagggctttt ttttatttaa taaaagcaag aaaacgcttg 926041 cgaaaaaaat acgggagaaa aagaaatttt tcctttgaca aatcttcttt catttattaa 926101 tattttatct tgtgaactat tattgaggaa tgaggtgaaa aggagttgac tgaatcagaa 926161 cgtgctttgc tcacttttga acagctcttc gatacgtctc gggcgatata taaaaaacag 926221 aagaagatat tggagattgt gcttgagcct tttgatatta cagtccttca atatttgctg 926281 atgtttaaaa ttcatcaaag cggaagcacc ccgctaagca agctggcaat gtcgcttgat 926341 cttaagcctg cttctgtgac gcggatgaca gatattctgt ataagcgcca attgatgaat 926401 cgatatgaca gtccggatga ccgccgtatc gtcatgattc agttaaccga agagggggaa 926461 gaactgatag aaaaagccgc tgtgcaatat gcaaaaatgg gtgctggctt gtaccaaaag 926521 cttgatacct cccagctgca gtatttgcgc aaactagccg gaagtttaac gaagcttgct 926581 gaaggctgtt cagaaaaaag cggtaattaa aaacttctca catattttca ccagctttcc 926641 gcaaaatgat agaggatgaa acgaaaggag aaaacaaaat gaacagagga cgtttaattc 926701 tgaccaacat tatcggtttg attgttgttc ttgcaattat agctggaggt gcttactact 926761 attatcaaag cacaaactac gtaaaaacag atgaagcaaa agtagcgggc gatatggctg 926821 ctattactgc tccagcagca ggtaaagtat ctgactggga tctggacgaa ggaaaaacag 926881 tgaaaaaagg cgacacagtt gcaaaaatca aaggtgaaca aactgttgac gtaaaatcca 926941 ttatggatgg cacaattgtg aaaaacgaag tgaaaaacgg acaaaccgta caagctggta 927001 caacaattgc acaaacgatt gacatggaca acctatacat cacagcaaat attaaagaaa 927061 cagatattgc ggatattgaa gtaggaaata gtgtagacgt agtagttgac ggagaccctg 927121 atactacatt tgacggtact gtagaagaaa ttggttatgc gactaactca acttttgata 927181 tgcttccttc tacaaattca agcggaaact acacaaaagt aacacaaaaa gttcctgtga 927241 aaatttcaat caaaaaccca tctgataagg tgcttcctgg aatgaatgca tctgttaaaa 927301 tttctgagta aaacagatca gtcatcaaac catgaaagga ggttgtctta gatggctaca 927361 ggcaaagaaa aaaatgcaaa aaaccctatg tcattgctga ttgtgctaat ggcgggttta 927421 tttttggcaa ttctaaacca aacactgctt aatgttgcaa tgccgcactt aatgactgaa 927481 tttggcgtaa gtgcaacgac gattcagtgg ctgacaacag gttacatgct tgttaacggt 927541 gtattgattc cgttatctgc tttcctgatt acacgatttg gccagcggag tctctttctc 927601 gtcgcgatgt tttgttttac gctcggtacg ttagtctgcg gtatcgcacc taacttctct 927661 acaatgctga tcggccgttt gattcaggcc gtgggcggag gtatcttgca gccgctcgtt 927721 atgacaacca ttctgttaat tttcccgcct gaaagcaggg ggaaaggaat ggggattttc 927781 gggctagcga tgatgtttgc tccagcggtc ggcccgactc tttccgggtg gattattgag 927841 cattatacat ggcgcattat gttttacgga cttgtgccga tcggcgcaat tgttatcatt 927901 gtggctttct tcatctttaa aaatatggtg gagccgcaaa aaatcaaact cgatactctt 927961 ggcgcaatcc tctcgattgt cggattcgcc tccttattat acggagtcag tgaagccgga 928021 tctgacggct ggaccgaccc gattgtattg tctacagtta ttatcggagc cattgcaatt 928081 gttgcttttg ttgttcagca attgcgtcat gatgatccga tgcttgattt cagagtgttt 928141 aaatatgaca ttttctcact ctcgagtgtc attaatatca ttattacagt ggcactttac 928201 actggtatgt tccttttacc gatttatctg caaaacctgg tcggctttac ggcgcttcaa 928261 tccggtctgc ttctgcttcc gggtgcgatc gttatgctga ttatgtcacc gatctcaggt 928321 attttgttcg ataaattcgg accgagaccg cttgcgatta tcgggcttct cgtgacagtg 928381 gtaacaacgt atcaatacac gcaattgaca attgatacac catatacaca catcatgctg 928441 atctattcaa ttcgtgcatt tggtatgtct ctcttaatga tgccagtcat gacagccggg 928501 atgaaccagc ttcctgcccg tctgaacagc cacggaacgg cgatgagtaa cacgcttcgc 928561 caaatcagcg gatcaatcgg aacaagttta attacgacga tttatacaaa ccggacgaca 928621 ttccattatt cacaaattgc agataaaaca agcacggcgg acccgaactt cctccatgcg 928681 ttccaaaatg cagtttcgaa tttaatggtg aatatgaatg tgtcttatga tacggcgaaa 928741 acatatgtgt actcacatat ttataaacac gcatcactcg attccaatgt catggggata 928801 aatgatgcct ttatgtgggc aaccttattc tgtgtagcag gtttgatttt aagtatcttc 928861 ctgcgtgacg tcagaaaaga taaattgcgt aagaagaaaa aagaggagct ttcattactt 928921 cctgctccaa aagaagctaa ggaatcttaa tctgtacagg gaggtttcct gaatgaaaat 928981 ttatgtagtg tatgatagtg aaggcgaaca tactaaagtg cttgcagaag cgattgctga 929041 aggcgcgaga gaaaacgacg cggctgaagt gttcatcgac catgtagatc aggctgatat 929101 ccgcaagctt aaagatatgg atgcgattat ttggggatgc ccagggcatt tcggaacaat 929161 cagctccggt cttaaaactt ggatcgacag acttggctac ttgtgggctg aaggcgagct 929221 gatcaacaaa gtcggtgctg tcttctgcac aacggcaaca acacacggcg gcttggaaat 929281 gacaatgcac aatttaatca cgccgatgtt ccaccaaggc atgattgttg tcggactgcc 929341 tggcaacgtg cctgaaaacg cactttatgg ctcttattac ggagcaggtg tcacttgtcc 929401 ggtagacagt gatgagttaa tgtctgagga aggtattcag cttggacgcg cgttgggaag 929461 acgtgtcagc caagtcacag gaaacctaac agcaggacag taaggagagg ttgaaatggc 929521 cattattata gcaataattg ctgctgtcat tgtcattgcg gcccttatta catttaacgt 929581 ccgcaacgcc tcacctggac ctgagaagca agaagcaacc gatagaatcg cacctccaga 929641 agaggaaaaa aacgaagcgc attaccctgc tgaagcaagg gctgccgagc atacgccatc 929701 cgttgtcaaa aacgattctc caaaagagaa gcgtgacaca atgggtgatg atatttacag 929761 gcaggcgctg caaaagttta agcattctga tgaagttcat gcagaagaag aggtcactga 929821 ggaaagtgac aaaatgcagg accgcagcta tcgtgatgcg ctgctctcta tgaaaaataa 929881 gaaaaagtaa tgaaaaaggc aaatccgttt actcatgcgg gtttgccttt tttgctgttt 929941 ccatcaatta tgtttttatc aaataaatcc atggaatatg ttgtattcca ccttgatcta 930001 gtgtactatg ttactcatac accgaggatt ttttccggga ggtaaagaca tgaattcttt 930061 tttaggttta ttaaagaaag atatcaagct ttcaagaatg tggctgctag tatggatatg 930121 cggaatcatt ttcttattgg gaacaggcca tattatagct tctcgcacga aagaacctct 930181 agtcattttt ggtttttttg ttgcagttgc tttttttctg cttttcttat ctcctgtttt 930241 tgttttttat caccttcgca aggaagggaa atcacagctt tggctgtaca atccaaatgg 930301 cggcttatgg ctgttttctt ctaaattggc agcatctttg ctctatcaat ttgtgattca 930361 gttggcatta acagcctatg gcatatggat gtatcatatg ctctctgtaa aaaatctgct 930421 ggagcatcaa gttgatataa cgagtacagt ggctttgctg aatatgtatg ggcttatttc 930481 ttcgttagat atgtcagtaa cagtcattgt gttttggact gtttttcact ctctcagaaa 930541 ttggcgcgga atgcggtggg ctgcgatggt tctgttggtc gcaatgtggt tattcttcga 930601 tgaatacatc ataagccctt tggttgaatc tcaaaagcat ttctggcctg taacagtcta 930661 ttgcaatttt gatttccact tccacaatgt ttggagattg gaactaaaac ctatccatct 930721 gtctgtgcta gggtttccta ttgctatagt catcacattc ttgctgctca tcatggcttc 930781 aaaactgctt gatcgtaaag tagaggtgta aatatggaca atcaattcca atcctcgaaa 930841 ccgatttatc tgcagatcgc tgatcagatc ttttataggc tggtcaggaa ggagctgctc 930901 ccaggagaca agcttccttc agtaagagaa atggcgattc aaactaaagt aaatcccaat 930961 acaattcaaa gaacttacag tgagatggaa aggctgggta ttgtggagac aagaagaggt 931021 caagggacgt ttattgcgga aaaagcagaa atcgtagacg agctgaaaga caagctgaca 931081 cgagaggtgc tggaaggctt tgtcaagcaa atgaaagagc tggggctaac gaaagaagaa 931141 atgttagaag ggattaaaac attcacagag ggaggctaaa atggaaatca agctagaaca 931201 tgtatcaaaa aaatacggcc gccatacggc cgtcaatgat gtgtcaatca ccctatcatc 931261 cggacggatt tatggcctga ttggaccgaa cggcagcggc aagtcaacga ccctgaaaat 931321 gatggctggc cttctgtttc cgacttcagg atttgtaaaa gttgatgaag agcaggttac 931381 gagagaaatg gtgcgtcaaa cggcttatct tactgagctt gatatgtttt atccgcattt 931441 cactgttaaa gatatggtga atttttatca gtcgcagttt cctgattttc atacagaaca 931501 ggtttataag ctattgaatg agatgcagct gaatccggaa aaaaagatca aaaagctatc 931561 aaaaggaaat cggggcaggc tgaaaatcgt tcttgcttta gcgagacggg cagacgtcat 931621 cttgcttgat gaaccttttt ccgggcttga tccgatggtc agggattcca tcgtaaacag 931681 ccttgtgtcg tacattgatt ttgagcagca gattgtcgtg atcgcgacac atgaaattga 931741 tgaaattgag actttgttag atgaagtaat catcctcgcc aatggagaaa aagttgcgca 931801 gcgtgaagta gaagatattc gtgaacagga aggcatgtct gttttgcaat ggtttaaatc 931861 aaaaatggaa gtttgctaga aagaggagga atatgatgaa aacagtgttg gaattgaaaa 931921 acgtgactaa aaacatcaga ggccgaacga tcattgatga tctcagtttt acgattcgtg 931981 aaggcgaggt attcggtttt ttaggaccaa acggagcggg gaaaacgaca accatccgga 932041 tgatggtggg gttaatgaag ctgtcgaaag gtgatgtcct catttgcggc caatcaatta 932101 cgaaagaata tgccaaggcg attaagcata tcggagcgat cgttgagaat cccgagctgt 932161 ataaattttt gagcggatat aaaaatctcc agcaattcgc aaggatggtc aagggtgtca 932221 cgaaggaaaa aattgatgaa gttgttgaac tggtcggttt aacagacaga atccacgaca 932281 aggtgaaaac atattctctg gggatgagac agcgtcttgg cttggcacaa tgccttctgc 932341 acgatccgaa agtgctgatt ttggatgaac cgacaaacgg ccttgatccg gcggggatca 932401 gagaaatcag agatcattta aagaagctga cccgagaaag aggaatggct gtcatcgttt 932461 caagccacct gctgtcagaa atggaactga tgtgtgatcg aattgcgatt ctgcaaaaag 932521 gaaagctgat cgatattcaa aatgtaaaag atgaaaacat tgatgagaat gatacatatt 932581 tcttccaggt tgagcagccg agtgaagccg ctactgtttt aaatcagtac gatttgctga 932641 gtaagacaaa tggtgtagaa atcaaactgg ctaaagagga agtccctgcg gttattgaat 932701 tgctggtgat gcagcaaatc cgtatttatg aggtcaaggt cataacaaaa tcattagagg 932761 accgtttctt agaaatgaca ggtgaaacaa aagaggaggt tcagcatgct taatttgatt 932821 tataatgagt ggctcaaaat tttcagccgt gccggaacat gggtgatgat cggaattctg 932881 gggctgacaa tggttggatt tgcatttttg gcgaatcatt tttctgccgg tgaatcaaat 932941 tcccattgga aacaagagct tcaagcacaa aacgccgaat taaagaaaga aatcaaagaa 933001 gatccttcac tgaaagatgg gtataaagaa acaatcacac tcaatgacta tcgcatcgag 933061 cataatatcc ctagtgacac gggctatacg gtatggtctt atgtaacgga ttcagcaaac 933121 tttaccatcc ttaccggtct gtttactatt atcatcgcgg ccggaattgt cgcgaacgaa 933181 tttaattggg gaacgattaa gctattaatg attcggccgc tcagtcgttt tcaaattttg 933241 atgtccaaat atattacagt tctcctgttt gggctcctgt tgctgttgat tttatttatc 933301 ggttctactt tattagggtt gatcttcttc ggaacgggtg gtgaaaccgc cgcgaatatt 933361 catttaatct ataaggatgg ccatgtcatt gagcaaaaca tgatggggca tttggctaca 933421 acgtatcttt ctgaatccgt ctcggcttta atggtggcga cgatggcgtt tatgctgtct 933481 gcggtattca gaaacagctc tcttgcggtt ggtttttcca tcttcttgtt ggttgccggt 933541 acgactgcaa ctgcatttat tgcagcgaaa tttgactggg caaagtatat attgtttgct 933601 aatgtcgact tgactcagta tgtggatggc acaccgttaa taaaagggat gactatgacg 933661 ttttctctcg tcatgctggc gatctacttt atcatcttcc tgttgcttgc tttcggaatc 933721 ttcatgaagc gggatattgc aaactaataa aaaaagctgt tttgcttatg caaaacagct 933781 tttttgtcaa aataaaaact gcaggtttgc acctgcagtt tttcatatca atttatgctt 933841 acgcttcttt agtaacgtta gcagcttgtg gtccgcggtt tccttcaacg atttcaaaag 933901 aaacagcttg gccttcttct aaagttttga agccttcgcc ttgaatagca gagaaatgaa 933961 cgaatacatc gtcttgacct tctacttcga tgaatccgaa acctttttca gagttgaacc 934021 attttacttt accttctaac atgaaatttc ctcctaaagc gatcataacg cttaaattca 934081 ctattcttgc tcttaacaaa ctttcaagac gaaaactctt acaaaacttt cttcttaaag 934141 atagttcgaa caaaaataat tacctttact ctaccagtaa tcttcagaaa aaacaactgc 934201 ttattgaaat ttttttcgga aaataccata tttatttttc aatttgatat ttatttacgg 934261 aaattcatct gttttctcga tatgtgatca tacgtttgcc ttagtattcc ttcattttgg 934321 gaagataagt aataggaatt gacaacctta ttggatatga gtaaggtaaa agttaatcaa 934381 tattacaaat gacaacgttt atcaactaag agagcgtatg atttttatgt ctgatattgc 934441 ttgcatgctc taatacatag ataggagtat ggtcacaatg aaaaagtggc ttatatgcag 934501 tttcgtcctt gttcttctcg tttcatttac tgcatgttca ccgtctgcag aacatgaatc 934561 gataaaaatc gggattgctg agtctgacgg ggcaatatgg aactatattg ctcaaaaggc 934621 tgaagaggca gggctggata ttcagctgat ccctttttct gattatgcgg agtctgatat 934681 cgcacttgct aacaaagaaa ttgatgccaa cgcctttcaa accatttcat attttcagtc 934741 gttcactgaa aaatacaaac ttaatttggc accgctcggg acgacataca taacgcccat 934801 gggcatttat tcaaaacgat atgaacgaat ccgagatata tcgcggggag ctgtcgtttc 934861 tgttccggat aaagcgttcg attttggcag ggcgcttacg gtgctccagg aagcgggttt 934921 gctaacgctg aaaaacggat ttaacggaac aggttcagtt gatatgatta aagataatcc 934981 gagacacctg aaattaaaag ctgtccggca acaggatgca gtgagcggtg ccgacgtgtt 935041 tgtcatgaaa ccatcagaag caaaaaaagc gggcttgaac ccgaaaaagc atacgctaaa 935101 gagcggcgga ctcatgtctg aggaagagat gaatttgatt gttgtcagag cggaggatca 935161 agatcgggaa gcgctgcaaa ccattcttga gctttatcaa gctgatgata cagcggcatt 935221 tatagaaaaa gaatatcagg gagatcttgt cccggctttt ctgcctttga aacgtctttc 935281 agattggaag aatgaattcg aacattgaat tcattctttt ttttctgaaa aacacactct 935341 gttccgtccc gtttctttcg ctttgtaaag catttgatcg gcaagaatgg gcaaggatcc 935401 tggctgttcc gtattattgg ggtaatgagc ggcccctagt gatatcgtaa ctgaaagctc 935461 gtcgccgttt gttaatacaa tcggtgcatc acttacagtg ctcctgatcc gttcagcgat 935521 ccgggctgct ttatcaagag aacagttcgg caggagcacg gcaaattctt caccgccgat 935581 ccgagcggca ggatcagtat ttcggatggt ctgcttcaga cgtaacccta gctctttgag 935641 cacctgatct ccttcatgat ggccatattg gtcattgatg gtcttaaaat gatcgatatc 935701 catataaatc agtgcaaatt gaaaatgcgg ggtatcggcc gcctgctgat acagagcttt 935761 tgtggtttct tcaaattttc ttcggttata cacgcctgtt aaaaagtcaa agtgcgcctg 935821 aaacttatat tgtttaaaaa gaagatgtgc atttgtttca tgatcaataa tatataaact 935881 gagcatgccg cccgctattg atatgatcca aaaatacaaa tgaagttcgt atgaatgtaa 935941 atctataaga aaataaaagg aaaaggagat caagctattt gtgattatta aaagatagaa 936001 agcatgtttt agttgaactt tttttcttct agaaacaatg agtgacggaa tggcagcgat 936061 acaaatgata ataaccgagt atagtgcaga tgtgttcatc gtaatcagca agcggcctgc 936121 agtgatcatg gccagggccg ttgccgttga aacccagcct ccataaagag cggcaatcat 936181 aatagggata tttcgaagat caataattga atgctgatag gtaaatccaa aaaccatcag 936241 aataaccccg agcaaaccgc aggccagtcc tttaacagct tgaaaggata tgctgtcttt 936301 tttatgtact agcctttctt taaacaggtg ggtgaagaga taattaaatg tgattaaaat 936361 ggtcaaattt acaaacagtt ctttcagcaa atattatcac ccttatataa ggtactaaag 936421 atggaaggga aagaaaagaa caaaaaaggc attatataag gtttttttac ttgaattgat 936481 aagttaaaat aattcgcact tgacccatcg gaattagtgt aatatagtaa atgagaaaat 936541 ttgaagggag agtttacctg ctttggagac tttactggtt gtattacatg tatttatttt 936601 atttttactt atcttagggc tctttgttat gcagaaaaaa catgtttcct tctctaaacg 936661 tgtatttact gcgctggggc tggggattgt attcggattt gcgcttcagc tgatttacgg 936721 cccgacttca aatatagtca ttcaaacagc cgactggttt aatattgccg ggggcggata 936781 tgtcaaattg cttcagatgg ttgtcatgcc gctcgtcttt atttcgattc tcggcgcctt 936841 tacaaagctg aagctgacaa aaaatcttgg gaaaatcagc ggtttgatta tcgggatttt 936901 agtagcaaca acagcagttg ctgcagctgt cggtatcgcg tccgcgcttt catttgatct 936961 gcaggcgatt caggttgacc aaggaagtac agagctttca cggggacagg agcttcagca 937021 gaaatcagag gatatgacag cgaaaacgct gccgcagcag attgttgaac tgctgcctgg 937081 aaacccgttt ttagatttta cgggagctag accgacttca acgatcgctg tcgttatttt 937141 tgccgctttc cttggagtgg cattcctcgg cgtaaaacac aaacagccgg aacaggcaga 937201 aacatttaaa aaactggttg atgccgttta tgccattgtc atgcgtgttg tcacactcat 937261 tttgagactg acgccttatg gggtgctggc catcatgaca aaaacaattg caacgagtga 937321 tcttgacagc attctaaaac tgggcatgtt cgtgattgca tcatatgccg cgttaatcac 937381 tatgtttatc attcatttgc tgctgctgac gttcagcggc ttgaatccgg tgatttattt 937441 gaaaaaagcg gtgcctgtac ttgtatttgc atttacgtca aggtctagcg caggtgcttt 937501 accgctgaat attaaaacac agagaagcat gggtgtaccg gagggaatcg caaactttgc 937561 cggttcgttc ggtctttcga tcggccaaaa tggatgtgcc ggcatttatc ctgcgatgct 937621 ggcgatgatg attgctccga ctgtcggcca aaatccattt gacccggtgt ttattatcac 937681 tgttatcgca gtcgttgcca tcagctcctt cggggttgcc ggagtcggcg gcggagcgac 937741 attcgcggcg cttcttgttt tatcatcatt aaacatgcct gtcgcgctcg ccggtttgtt 937801 aatctcaatt gaaccgttaa tcgacatggg gcgtactgct ttgaatgtca gcggaagcat 937861 gacatccggt cttattacaa gtaaggtcac aaaagaaatt gatcaagggg catttcatga 937921 tcaatccaga gtgattgaag ctgaagaagc gtaacatatg aaaacgtgta atccaagagg 937981 attacacgtt tttttaacgg ccaggctcta agtcctccag catttccatc atcgtgttgt 938041 cgtccatgac attcattgcg ttttgttcaa aatgaatggg ttcagcataa tgcggctgtc 938101 tttttttcgc ggctgtctca gtttgcctag tttgagactg tgtatgctga tgctgtggtt 938161 gctgctgtcc agcgtgctgg tgctgacggc cattttgccg ctggctttga tgctgcgaac 938221 ggtcctggtt atcaccgctg cttccgctgc ttccgctaaa tgcttgtttg accatgtttc 938281 ctacattaga agcatcaaac gtgttatttt ctgaatttcg tctgttcatt tgtcctgtga 938341 taaacccgct gattctttgg cggatctgag gtgataatgc agtaataagc atagttgatc 938401 ctatgatcaa tgctgcgggg ctgattcctc ttcgctggtt gaacaacatg atccctcctt 938461 tgcagtgtat tcatattttc cccctcgtta gacaaattaa ccgttatatt tcccgggaaa 938521 gcatttcctc cagatttgca tgcataatta aagccagtta gaaaaaccta taagtaaagt 938581 gataaaggag gaattcacat gtttggaaaa aaacaagtcc ttgcgtctgt gcttcttatc 938641 cctttgctta tgactggctg cggtgtagcc gaccaaggtg agggcagacg tgataataat 938701 gatgtaagaa acgtaaatta tcgaaatccg gccaatgacg atatgcggaa tgtaaacaat 938761 cgggataacg ttgacaacaa tgttaatgat aatgtcaata acaatcgtgt aaatgacgat 938821 aataacaacg accgaaaact tgaggttgct gatgaagcag ctgataaagt aacagaccta 938881 aaagaagtaa agcatgccga tatcattgtg gctggaaatc aagcctacgt tgcagtcgtt 938941 ttaaccaatg gaaataaagg tgcagtagaa aacaatctga agaaaaaaat agccaaaaag 939001 gtaagatcta ctgacaaaaa cattgataat gtttacgttt cagctaaccc tgattttgta 939061 gagcgtatgc aaggatatgg aaagcgtatt caaaatggtg acccaatcgc cggattattt 939121 gatgaattta cacaaactgt acagcgtgta ttccctaacg ctgaataaat gaaagaagcc 939181 gcacaatttg tgcggctttt tctttgcgtt aatgacacac tgcgaactca ggctgcatag 939241 agtaaaaata aaaaggtaca agacggaccg gctcagggag ggagacgttt gcgggatggc 939301 ataggaaagc gtgcggcatc cgctctattc ctgtgcggag tccttgtgat gctggctgta 939361 agctcagcca tcgtatcaag cgcgatgtat atcctgtctt ttccaggtca ggcatctgga 939421 ataacaaaag aacaagtgac gaagcacatg aagaaagagt cattcaaaca ggccgatatt 939481 tattacactt ctaaggaaaa gtccttactg ccattgacga aagaaacgct tgaatatgcg 939541 gtcagtatta atcagattat gattggatat tcgaatcaaa agcctattga cattattttt 939601 tttcctaatg aaaaacagat ggaggcttac tccggtttat tggatgtagt tggtttttat 939661 tctgaacggg agcagctgat cggattgttg cctgaagaga aaaagaaact gttagaaggg 939721 gacgaggtag cggtttattt gtaccagaga ttgttgattc atgaatactc gcaccatgcg 939781 tttcaccaga aattgaagga gcttgagacg gatcccgatg agtttccgtt atggtttcat 939841 gaagggttaa gcgagtggat tgcgaactat gaattgctca tagatccgat cacgttttct 939901 gtcgtgccct ttgaccgttt gcagactgat cgagactggc aggaagctag agccgaatat 939961 gacactgatg tctatttgca aagcttttat atgatcgatg agctgacgga caaatacggg 940021 aaagacatta tttcagaaat gattaaggaa acggcaaaaa aaggggactt tgaaaaaggg 940081 tttaaatcag caacaaagga aagtcttgat caatttgaaa aagattttaa gaaaaaattt 940141 gaaaaaaaca gtgcggcatt ggatagtatc tatccaatgc ctttgttatt agtgaagtcc 940201 ttgctgaccc attccgcctt gtgtcggagg catttgtcct tgggcagggg cgaatgaatt 940261 tcgcagctgt tccatatcct gcgcatcaag ctgaggaacc tggtaatagc cgtgtttgtt 940321 ttggtatagg aaaatttcaa atgccatttc aacatactcc tgaatttgcg cagacagtac 940381 gcgtcttacg gccggatttg tcatttccag agaagccatc gtcagcatag aagcttgtgc 940441 tttaatcgcg caaagcattt gtcggctgat gatgctgtca tcaatatcat tcatggattg 940501 aacaggtttt ttaggctgtg acggctgcat gccgtaaaca gtctggttgt cttccttcat 940561 catataagtt gctgtttttt gtgaaggttc gcttcctgtt ttgaagcatt ctgcagttat 940621 attgtattga gatgtgatga attgatgttg acgatcaagg atgtttagta attcttgatc 940681 cttacagaat tgtctcagca tcataaactg atcaagcaca gtaagtgttc cggaaagcac 940741 ctcatgcata tcaaacattt catgtccgcc gtggttttta tgcggtttgc caggaatacc 940801 tttgttcatt tgggattgct gctgctgatt gaactgatcc aaaccgaatt cctccttttt 940861 tttcagatca gctgtatttt gtgtcagtct gccgtgtatt atgcagaagc ctgaaaggaa 940921 ttatatgctg tctgtcgaaa tgataagcag acaaaatcgt tgtcattatg tgtataaggg 940981 aggaaatatg atgaggcgta ttctgcatat tgtgttgatc acggcattaa tgttcttaaa 941041 tgtaatgtac acgttcgaag ctgtaaaggc agctgaaccg caacagccta tatcgattga 941101 gaaggcaata cagcaaaaag aaggacaggc acttgtcgaa ggatatgcag tcggccaggc 941161 tgtttccccg cagcattata aactgacaag ccctttttca aatgattata atgttgcgct 941221 ggcagaccgt aaaaacaaaa catcgcccga acacatcctt cctgtgcaaa tcccctccgc 941281 cttcagaagc caatttgggc tgcaaaccaa tccgcttctt cttgggaaaa agataacggt 941341 tcaaggaaag cttgaaaatt actttaacac gacaggactt aaaaacgttc agtcgatgaa 941401 cgtaaccgat gacacaaaaa ctccgccggc tgaacagcaa gtgaccataa atgaagcacg 941461 gggaaggctg aatgaagaag taacgataaa agggatcatt acagctgatc aaaacgcaat 941521 cggaggcggg aagctgtcga cctttttgca agatgaaacc ggaggcatta acatttattc 941581 gccatcccct gaacaatttc ccgaattaaa agagggtatg gatgtcacgg tgacagggaa 941641 aatcacgtct taccaggggc tgaaagaaat cgttccaaac tcatcaggca tcaaaatcaa 941701 ccagtcaaat caatccctcc ccgcccccaa acacttaaca atcaatgaac ttattaacgg 941761 cagcctaggt gatcagtatg aaggacgcct tgtgaaacta accgcttttg tttcctcaat 941821 tccaagttct cctgccggcg gcggttacaa tgtaacaatg attgatgacg accatcatgc 941881 aatgacgctc cgggttatga atgaaacagg ggtgataaac gagcttgatg agggcaaatg 941941 gtatgaattt accggtgtgt taagcagata ccaaaccttt cagctgcttc cgcgaaaatc 942001 ggctgacctg aagctgcttg aagagcagcc cgcacctccg tctgcagagg gagaatatga 942061 agggattgtt gaccgggtag ttgacggcga taccattcat cttaaatctc cggtgcttgg 942121 aacgacaaaa atccggtttg taaatgtaga tgcacccgaa acatatcaca caccaaaaaa 942181 tgacgcagat gaaaatcaat taagatttgg caaaaaagca tctgactatc taaaaacggt 942241 tctgtccccg ggtgataaaa ttactgtcaa ggtcgggagt gaagccaagg acagctatgg 942301 cagattgctc ggacaagtca taaccgaatc aggttcaaac gtgaacttag agcttgtaaa 942361 aaacggctat gctccgacgt attttatttg gccggttgac aatgaagagg attatcagca 942421 atttcaggcc gcagtagccg ctgcaaaaaa agatcaaaaa ggaatttgga atgaaaacga 942481 tcccctcatg gaaatgccgt ttgaattcag agccagagag caagggaaag gcctgacaag 942541 atatgtgggg gactcgtcga ataaaacata tgtgcagcca gctgactgga agaagatagc 942601 tgtggaaaac agaattttct tcgcctcagc aagtgaagcg gagagcgcgg gatataaaaa 942661 aaggcaaacg gcacctcaag aacatgtgcc gcttagaatt ctcagcatga atgatttgca 942721 tggcaaaatc gatcagcaat atgagcttga tcttgatgga aatggaactg tagacggcac 942781 gtttggacgc atggattatg ccgccgcata tttaaaagaa aaaaaggctg aaaagaaaaa 942841 ctcgctgatt gtgcacgcgg gagatatgat cggcggaagc tctccagttt cctctcttct 942901 tcaggatgaa ccgactgtag aactgatgga ggacatcgga tttgatgtcg gaaccgtggg 942961 aaaccacgaa tttgatgaag gcacggatga acttctgagg atcttaaatg gcggtgatca 943021 tccgaaaggc acaagcggat atgatggaca gaactttccc cttgtatgtg ccaattgtaa 943081 aatgaaatca actggagagc cctttttgcc ggcttacgac atcattaatg tggagggcgt 943141 acccgttgct tttatcggag ttgtcacaca gtcggcagct ggcatggtta tgcctgaagg 943201 aataaaaaat atcgagttta cagatgaagc aacagcggtg aataaggcgg ccgaagagct 943261 caagaaaaaa ggcgtgaagg ccatcgcggt tctcgcacat atgtcagctg aacaaaacgg 943321 caacgccatt accggtgagt ctgctgatct tgcaaacaaa acagattctg aaattgacgt 943381 gatttttgcc gcgcataatc atcaggttgt taacggtgaa gtgaatggaa aactgattgt 943441 tcaagcgttt gaatatggaa aagcgatagg tgtcgttgat gtagagatcg ataaaacgac 943501 aaaagacatt gtcaaaaagt ccgcggaaat cgtatatgtt gatcaaagta aaatcgaacc 943561 ggatgtcagc gcgtcagcca ttttaaagaa atacgaaaca attgcggaac cgattatcag 943621 cgaggtagtc ggcgaagccg ctgttgatat ggaagggggg tattcaaatg acggcgatac 943681 acctcttgga aacctgattg cggatggtat gagagctgcc atgaaaacgg attttgccct 943741 tatgaatggc ggcggcatac gtgaagcgct gaagaagggt ccaattacgt ggggagatct 943801 ttacaatatt cagccgtttg gaaatgtgtt aacgaagctt gagattaaag gaaaagattt 943861 aagagagatt atcaatgcgc aaatctcgcc ggtttttggg cctgactaca gcatcagcgg 943921 gtttacgtat acgtgggata aagaaaccgg aaaagcagtt gatatgaaaa tggcagatgg 943981 caccgagatc cagcccgatg ccacatatac attgaccgtc aacaacttta tggcgacggc 944041 gacaggagcc aaatatcagc caatcggact gctgggaaaa aatccggtga cagggcctga 944101 ggatttggaa gcgacagttg agtacgtgaa gagttttgat gagccaattg cgtatacaaa 944161 agagggaaga attaagcttg ctgaagccag tgatattgaa gaccctgtaa cagaagaccc 944221 gataacggaa gagcctggag atgatccggg gacggaggat ccgattaaag aggatccaag 944281 gccaggtgaa gatttgcctg atataaaaga aactccggga acagcaccgg ttcatcagct 944341 tccgccttca gccatttcga gattcaatga aataccaatc aacaacacaa aaaccgctga 944401 tactgctaat agcatcagca cattgccgtt acaaaccgag actgcggaaa gcgggtctga 944461 tcatcagctt ccggatacgt cagcgggcta ctataacttt atggtaatcg gtgcggcggt 944521 gacattgtca ggaacttatc tatatgtcag aagaaaaagg agcgcctcca gaacgtgaaa 944581 aaagttattc cactattcat cattgctgcc ggcctagtga tcgcaggcta tggaggcttt 944641 aaattgatcg atacgaatac gaaaacggaa cagacattaa aagaagcaaa gctggcggct 944701 aaaaagccgc aggaagcttc ggggacgaaa aatagcacag atcaagcaaa gaacaaagca 944761 tcatttaagc ctgagaccgg ccaagcgagc ggcattttag aaataccgaa aatcaatgca 944821 gagcttccga tcgtggaggg caccgatgct gatgatttag aaaaaggtgt cgggcattac 944881 aaggacagct attatcctga tgaaaacgga caaattgtgc tgtcagggca tcgggatacc 944941 gtgtttcgcc ggacgggaga gctggaaaag ggggatcagc tccgtcttct cctgtcatat 945001 ggagaattca catatgaaat tgtaaaaaca aaaattgtcg ataaggatga cacatctatt 945061 atcacgctcc agcatgaaaa ggaagagctg attctgacga cctgctatcc gttttcatac 945121 gtcggaaatg ccccgaagcg ctatattata tatggaaaac gagtgactta aaaagccgag 945181 gcagtgcctg cggcttttct tcatgaaaaa tatgtgcggc aaaggttttt catatcagca 945241 gggaaagggg cttcagcaac tatgagctcg tctgttatcg ggtgaaccgc ttgtacttta 945301 ttggcgtgca gtgcctgcct gtttagcagc ttgctcccgc ctccgtaaag cgagtctcct 945361 gtcaacggat ggccgaggct cgccagatga acacggattt ggtgtgttct gcctgtttcc 945421 agctctaatt caacgagcga cagccgttct ttcgcattgc tggccattac cttgaaatga 945481 gtgacggctg tttgcccgcc tggtgaaacc cggcgtcttg tcgggtgtga gcggtctctg 945541 ccgatcggtg aattaattgt cccttttttc gtccgtagct taccttcagc gatagcggta 945601 tacgtacgct tcagcgtctt tttctctaac tgctggtcta agatggcgtg tgccaaacga 945661 tgcttggcaa aaacgatagc gccagatgta tcctgatcaa gacgatggac gtggcgcacc 945721 ttacatgttt cgccatttat ctgataatga tacgcgatca aattagccag tgtgccggtt 945781 tgcccatcct cattcggatg cgtcgcgatg ccagcgggtt tattgatgat gagcatatga 945841 ttgtcctcaa ataaaatatc aagctcgcca tactccggaa tgaccgaaga tgcttcactt 945901 tcctgaagat caatgaacac gcggtctccc ttttttacaa tcatattgtt taagacggat 945961 tcgtgattga cctttatctg ttgatgggac atccagtctt gtatcactgg tttagaagct 946021 ttgagcgctg ttttgagtac ggaaaacagc cattggccgt cctgtttttc attgatgagg 946081 atctcaagcc ctctgccttt ttggttcatg ttaaatggct ccttttcgaa gcggaaggct 946141 gctgtttctc ataggaaaca cttaccttag ctttcgcgtt tttttctgtg ctattcttga 946201 gtaagactta ggatattcga tggcaagaaa ggtgattgac gtgagaattg tgaacgcagc 946261 aactgcagaa caggagagct ttatcaagga gctgtctatg gagctgatcc atgatgtatt 946321 tcctctttat ttctccgaac tggacattca gcgctttaaa aagaaaggcg ttctgtcttt 946381 aaataaccat tattaccaag gaacattaaa agaagcattt caaattatgg cttgtctgca 946441 aatgatacat attatcctga ccaagccttc gccgcactct gatttgagtg atcaggcgat 946501 ttttgaaaaa aacagcaaga tgctgaatga ttttgggatt tattttccgt ttgctttttc 946561 tgactttcaa aagaagacta acaaagcctt tttcggtcaa agaaggctga tataatcatg 946621 cggcaagggc ttttctattt ttagaaaagc tctttttgta tcagagaaat catatcataa 946681 aacctttcct ctaactccct ttttaaacgg ctcgtgtctg aacatactaa tgattgaaag 946741 gggtgctgac aatgagttca gttaaagata caatgacaac gcaggtggca accgtttctc 946801 cgaatcaaac gattcaggaa gcggcttctc taatgaaaca gcataacgtc ggggcgatcc 946861 ccgttgtaga gcaaggtgtt ttaaaaggaa tgctgactga ccgtgacatt gcattaagaa 946921 ctacagctca gggccgtgat ggccagacac ccgtttcaga agtgatgtca acagaactcg 946981 tatcaggaaa ccctaatatg agtctggaag acgcgtcgca gctgatggcc cagcaccaaa 947041 tccgccgcct tcctattgta gatcaaaaca atctagtcgg gatcgttgcg cttggagacc 947101 tggcagtcaa tcagatgtcg aacgagtctg cgggatcagc gctgacaaac atttctcacc 947161 aaaacattca ttaataagaa agagcttgca gtgtgcaggc tctttcttca cataaaacct 947221 tactttttga aagcagactt gtttcggggt atagtgagtg tatacatatg tctcaattcg 947281 tactaaagga gttgtaccca gtgattaaag cgttaatttt tgattttgac gggcttattc 947341 tagatacaga aacacacgaa tatgaggttc ttcaggaaat atttgaagag cacggctcag 947401 tgctgccgct atctgtctgg ggaaaggtca tcggaactgc tgcgggtttc cggccttttg 947461 aatatttaga agagcagatc gggaaaaagc tgaaccatga agagctcaca caattgagaa 947521 gagagcggtt tgccaaacgc atggaatcag aaaaagcgag acctggtgtc gaagcgtatt 947581 tgaatgcggc aaaggattta ggcttaaaaa taggccttgc ctccagctct gattataaat 947641 gggtgtccgg ccatttgaag caaatcggcc tgtttgatga ttttgaagtt attcaaacgg 947701 cggatgatgt ggaagaggtg aagccgaatc ctgaactcta tttattggcg gcaaagaacc 947761 tgggggtatc gccagcggaa tgtctcgcgt ttgaggattc tgtcaatggt tcgattgctg 947821 cgaaacgtgc aggcatgaag tgtgtcattg tcccgaataa agtaacgggt accttgatgt 947881 ttgaagacta tgatcacagg cttgaatcaa tggcggagat ggagctcgcc ctattgcttg 947941 atcatctgaa ctcacaaaac tagaaaggag cgagtaggtt gtctgagaaa ttagatttga 948001 cccggtttga aaagaaaatg gttatccgca atatcgaaga gaaagacatc gacaagatta 948061 tcgatcttca aaaggactgc tttccaggaa tggagccttg gaagcgggag catttaatca 948121 gccatttgga gcattttccg gaaggacagt tttgtgcaga attcgaaggt gaaattatcg 948181 gttcgtgctc aagtctcctg attaactttg atgaatatga tgaccgccat acgtggcagg 948241 acattacaga tgacggttat atcaccaacc ataatcctga cggcttgaat atgtacggaa 948301 ttgaagtcat ggtgcacccg aaatacagac gaatgaagat cggccaccgt ttgtacgagg 948361 cgagaaagga cttagccaga cgcttaaacc tgaaaagcat catcataggc ggacggattc 948421 caaactatca caaatatgca gaggaaatga cagcgagaga gtatgttgaa caggtgacac 948481 gccaccaaat ttacgatccg gttctttctt ttcagctgat gaacggcttt acccttatgc 948541 gaattaaccc gaactatctc ccggatgata cagcttcgat caagtatgcg acgctgatgg 948601 aatggaataa tgtcgattat ctaccgcagc agacaaaacg ctattataaa tcggcgttcc 948661 ctgttagaat ttgtgtgatc caatacgaaa tgaagaaaat ttattccttt gaggaatttg 948721 cgaatcaagt agaatactat gtcgatgttg cttccgacgc aagatctgat tttgcggtgt 948781 tcccggaaat tttcacaacc cagctgatgt ccttccttga ggaacggtca ccgagcttgg 948841 cggtgcagag aattaccgag tatacagaag attacatcag cctgtttact gacttggctg 948901 tgaagtataa cgtcaacatt atcggcggat ctcatttcgt cgaagaggaa ggcaagatct 948961 ataatatcgc ttacctgttc agacgggacg gaacgatcga gaagcaatac aaactccata 949021 ttacgccgaa tgaacgcaaa tggtggggga tcagcgcagg agaccaagtt cgcgtgtttg 949081 atacggactg cgggaaaatc gcgatccaga tctgttatga cattgaattt cctgagcttg 949141 cccggattgc ggctgataaa ggagccaaaa tcatctttac gccattttgt acagaagacc 949201 gtcaaggcta tctgcgtgtc agatactgtt cgcaggctag agcggttgaa aatcaaattt 949261 atacggttat ctctggaacg gtcggaaacc ttccgcaaac ggaaaacatg gatatccaat 949321 acgcccagtc aggcatcttt gccccgtctg attttgaatt cgcccgagac ggcattgtcg 949381 gcgaaacaaa cccgaatatt gaaatggtcg tcatcggcga tgttgacctg gaaattctca 949441 gaagacagcg ccaaaacggt acagtgcgcc agctaaaaga cagacgacgt gatatttatc 949501 atattcaata taaaaaataa ttcccaaaaa acccgcctga attggcgggt ttttttaaac 949561 aaaagcggaa ttgtttaggt gctttcttta aaataaaagt aaattgtata gtggatgtgc 949621 cttatggagt ttctgtattt tcgccatttc ctatatcata cagaaaacgg ctaggcttca 949681 cattgctatt gcaatggctg tccaagttgt ttcgagtgcg acctttatca gtacgatgct 949741 gagcattgtc actttgcctg ttttgctttg gaagctgcat cctctttctt cttgagaaag 949801 gggatgtttt attatttacg cggtttattg actctgaccc ggtctggctt tatattgaag 949861 gcagggaaat catcaccaag acatcacata aagagaaggt ctgtttcaat tgaattggca 949921 ttatagggaa cgctaatgaa atggagatga tggggatgga aaacattcag caaaatcagg 949981 gattaaagca aaaagatgag caatttgtgt ggcatgccat gaagggagcg catcaagcgg 950041 acagcctgat agcccagaag gccgaagggg cctgggtaac cgacacagac ggacgccgct 950101 atttggatgc gatgtccggt ttgtggtgcg tcaacattgg ttacggcaga aaggagcttg 950161 cggaggctgc ctatgagcaa ctaaaggagc tgccttacta cccgttaacg caaagtcacg 950221 cacccgcaat tcaactggcg gaaaagctga atgaatggct tggcggcgat tatgttattt 950281 ttttttccaa cagcggatcg gaagcaaacg aaactgcttt taaaattgcc cgccagtacc 950341 atctgcaaaa cggcgaccac agccgttata aattcatctc aagatatcgg gcataccacg 950401 gcaatacatt gggagcgctc tcagctaccg gacaggcgca gcggaaatat aaatacgagc 950461 ctttgagcca agggttcctg catgcagctc cgccagatat ataccggaat cctgatgatg 950521 cagacacgct tgaaagcgca aatgaaatcg accgcatcat gacatgggaa ttaagcgaaa 950581 cgattgccgg ggtcattatg gagcccatca ttacaggcgg aggcatccta atgccgccgg 950641 acggatatat gaagaaggtg gaggacattt gccggcgcca cggagccctt ttgatttgcg 950701 atgaagtgat ctgcgggttt ggacggacag gtgagccgtt cgggtttatg cactacggtg 950761 tgaagcctga tatcattacg atggcaaagg gaatcacaag cgcgtatctg ccattgtcag 950821 cgactgctgt gaaacgggac attttcgaag cgtatcaggg ggaagctcct tatgaccgtt 950881 tccgccacgt gaacacgttc ggcggaagcc cggctgcctg tgctttggcg ttgaaaaacc 950941 tgcaaattat ggaggacgaa cagctgattc agcgatcccg tgatcttgga gcaaagcttt 951001 taggtgagct tcaagctctg agagaacacc cggcagtcgg ggatgttaga ggaaaagggc 951061 tgctgatcgg aatcgaactc gtcaaagaca aattgactaa agagccggct gatgccgcca 951121 aagtaaacca agtggttgcg gcgtgcaaag aaaaagggct gatcatcggc aaaaacggcg 951181 atacagtcgc cggctacaac aatgtcatcc agcttgcgcc gccattttgc ctgacagaag 951241 aggacctttc ctttatcgtg aaaacggtga aagaaagctt tcaaacgata taatataaaa 951301 gtgaattatt aaaggagcac atgatgagtt ttcacaacca gccgatctta ccggctattc 951361 gcaatatgaa gcaatttgat gagtttttga acagttcatt ctcttacggt gttattcttg 951421 atattcatct cggccagctg aagggcgtga tcaaagaagc gcaaaagcac ggaaagaaca 951481 tgatggtgca cgtcgatctc attcaaggga ttaagcatga cgaatacggt gcggaattta 951541 tatgtcagga tatcaagccc gctgggatta tttccacaag atcgaatgtg attgccaaag 951601 cgaagcagaa gaaaatttat gccattcagc gcctgttttt gcttgataca agcgcgatgg 951661 agaaaagcat ggagtttatc ggcaagcata agcctgactt catcgaagtg cttcccggca 951721 tcgttccgtc actcattcag gaaataaaag agaaaacagg gattcccatc tttgccgggg 951781 gtttcatccg tacggaagag gatgtagagc aggcattgaa agcgggggct gtagctgtca 951841 caacatctaa taccaaattg tggaaaaaat atgaaaactt tttgacggaa agtgattgac 951901 accgctttca tgcactgata caattgcact aggttaatac attgtgatgg agaactcgga 951961 gaccacagca gctctttacg gcaaatgttt atgcacccgt aaagcggttt gttgtggttt 952021 ttttattctc ttcttctcta tcatgctttt taatcgtgac tttaggagga atgtgctatg 952081 acagcatttt ggggagaagt catcggtacg atgctgctta tcatttttgg tgcaggtgtt 952141 tgtgcaggtg tcaatttaaa gaaatcgctt tcattccagt ctggctggat tgttgttgta 952201 tttggatggg gattgggtgt tgccatggcg gcatacgcgg ttggcggcat cagcggtgcc 952261 catttgaatc cggcgctaac gatagcgctt gcatttgtag gagattttcc ttggaaagag 952321 gttccggttt atattgcggc gcaaatgatc ggagcgatca tcggtgcggt gattatttat 952381 ctgcattacc tcccgcactg gaagtcaacg gatgatcccg ctgccaagct gggtgttttc 952441 tcaacagggc ccagcattcc gcatacattt gcaaacgttt taagcgaagt gattgggaca 952501 tttgtccttg tacttggaat cttggccata ggtgcaaatc aatttacaga aggacttaat 952561 cctttaatcg tcggtttcct cattgtagca atcggtattt ctctgggagg caccaccggc 952621 tatgctatca atcctgcacg tgacttaggt ccgcggatcg cccacgcttt tcttccgatt 952681 ccggggaagg gctcatcaaa ctggaaatac gcatgggttc cggtagtcgg cccgatttta 952741 ggcggatcat tcggcggtgt attttacaac gctgcattta aagggcacat cacaagcagc 952801 ttctggattg taagcgttat attggttgtg gtattgttag gactctatgt ttatacgaaa 952861 tcacattctg ctaaaacatt atcaaattct aaatatattt aatcaaaggg gagacatctt 952921 atggaaacgt acattttatc cttagatcag gggacgacaa gttcaagagc gattctgttt 952981 aataaagaag gcaaaattgt ccactctgct caaaaggaat ttacacaata cttcccgcat 953041 cctggctggg ttgagcataa tgccaatgaa atttggggct ctgtcctcgc ggttatcgcc 953101 tcagtcatct ctgaatcagg aatcagcgct tctcaaattg ccggcatcgg catcacgaac 953161 cagcgcgaga cgacggttgt gtgggataaa gatacaggaa gtcctgtcta taatgcaatc 953221 gtttggcagt ccagacagac gtccggcatt tgtgaggaac ttcgtgaaaa aggatataat 953281 gataaattca gagaaaaaac agggctttta atcgatcctt acttctccgg cacgaaggtg 953341 aagtggattt tagacaatgt ggaaggcgca agagaaaaag cggaaaaagg cgagctgctg 953401 tttggaacga ttgatacgtg gctcatttgg aaaatgtcag gcggaaaagc gcatgtgacc 953461 gattactcca atgcctcaag aacactgatg tttaatattt acgatttaaa atgggacgat 953521 gaactgctcg acattctagg cgtaccgaaa tccatgctcc ctgaagtgaa gccgtcctct 953581 catgtgtatg cggagactgt tgattatcac ttcttcggaa aaaatatccc gattgctgga 953641 gcggcaggcg accagcagtc cgcattgttc ggccaggcat gctttgaaga aggcatgggg 953701 aaaaacactt acggcacagg atgtttcatg ctgatgaata ccggggaaaa agcaattaag 953761 tccgaacatg ggcttttgac aacaatcgct tggggcattg acggaaaagt gaactatgcg 953821 ttagaaggga gcatttttgt cgcaggctct gccatccagt ggcttagaga cggtttgaga 953881 atgttccagg attcatcgct aagcgaatct tatgcagaaa aagtggattc aactgacggc 953941 gtgtatgttg ttccagcatt tgtcggactg ggaacgcctt actgggacag cgatgtgcgc 954001 ggttcggttt tcggcctgac aagagggaca acaaaagagc actttatccg tgcgacactg 954061 gagtcattgg cttatcagac caaagatgtg cttgacgcaa tggaagcaga ttcaaacatt 954121 tcattaaaga cgctccgtgt agacggagga gctgtaaaaa acaatttcct aatgcagttc 954181 caaggagacc tgttgaatgt tcctgtggag cgcccggaaa ttaatgaaac gactgcactt 954241 ggcgcggctt atttggcggg tatcgctgtg ggattctgga aggaccgttc tgaaatcgcg 954301 aaccagtgga atctggataa acggtttgag cctgaattgg aagaagaaaa acgaaatgag 954361 ctgtataaag gctggcaaaa agccgtgaaa gcagctatgg cttttaaata aagtaatact 954421 atggtataat ggttacaagt taataagaac ggtcctgaga tgaggagaga ccacagcacc 954481 aaagtgtaag catgcacttt ggctgttgtg gtctcttttt ctatttaccg tgacaacaag 954541 gaggaaacgt aatgatgaat catcaatttt caagtcttga aagagatcgc atgctgacag 954601 acatgacgaa aaaaacatat gacctattta ttatcggagg aggaattaca ggagccggaa 954661 cagctcttga cgcggcatca aggggaatga aggtcgcact aagcgaaatg caggactttg 954721 cggcgggaac atcaagccga tcaacgaagc tggtacatgg cggcttgcgc tatttaaaac 954781 aatttgaagt gaaaatggtc gctgaggtag gaaaagagcg ggcgattgtg tatgaaaacg 954841 gcccgcatgt cactacaccg gaatggatgc tgcttccgtt tcataaaggc ggcacattcg 954901 gttcatttac aacatctatt gggttaaggg tttatgactt ccttgcaggt gtgaaaaagt 954961 cagaacgaag aagcatgctt tcagcaaaag aaacgctgca aaaagagcct ttggtgaaaa 955021 aagacggctt aaaaggcggc gggtactatg tggaataccg cactgacgat gcgagactga 955081 ccatcgaagt catgaaggaa gcggttaaat tcggggcaga gcctgtgaat tactccaaag 955141 tgaaggagct tctttacgaa aaaggcaaag ccgtcggcgt attaattgaa gatgtgctga 955201 caaagaaaga atataaagtg tatgcgaaaa aaattgtcaa tgctacaggc ccttgggtcg 955261 atcagctcag agaaaaagac cattcgaaaa acggaaagca tttgcagcat acaaaaggca 955321 ttcaccttgt atttgaccag tctgtctttc cgctgaaaca ggctgtatat ttcgatacac 955381 ctgatggccg gatggtattt gcgattcctc gtgaaggcaa aacatacgtg ggaacaacag 955441 acactgttta caaagaggcg ctggagcatc cgcggatgac aacggaggat cgtgattatg 955501 tcatcaaatc aatcaattac atgttcccgg aactgaatat cactgcgaat gacatcgaat 955561 ccagctgggc ggggctgcgt ccgctgattc atgaagaagg caaagatcct tctgaaattt 955621 cacggaaaga cgagatttgg acatctgact caggcctgat caccattgcc ggcggaaaac 955681 tgactggata cagaaaaatg gcggagcaca tcgttgatct tgtccgtgat cgcttaaaag 955741 aagagggcga aaaggatttt ggaccatgta aaacgaaaaa catgccaatc tctggcgggc 955801 acgtcggcgg ttcgaaaaat cttatgtcct tcgttaccgc gaaaacaaaa gaaggaattg 955861 cagccggttt atcagaaaaa gacgcaaaac agcttgcgat cagatacggc tctaacgtag 955921 atcgcgtctt tgaccgggta gaagcgctga aagatgaggc cgcgaaacgc aacattccgg 955981 ttcatattct tgctgaggca gaatacagta tagaagaaga gatgactgca acccctgctg 956041 acttctttgt ccgcagaacg ggacgtttat tttttgatat caattgggta agaacatata 956101 aagatgccgt tattgatttt atgagcgagc gattccaatg ggatgagcag gcgaaaaaca 956161 aacatacaga aaacctcaac aagcttttac acgatgcggt cgtaccgctt gagcaataaa 956221 tcataacggg ctgtctgcag cccgttattt ctttttacgt gccgaaaggg ggagatctca 956281 ggttatcaag tgacagaggc acccgcttca tataaaataa tggcataagc tgatacatag 956341 gaggacgaat atgacttgga gaaagagcta tgaacgctgg aaacagacag aacatttaga 956401 tctggaatta aaagagcgcc ttattgaatt agagggagat gaacaggccc ttgaggactg 956461 tttctataaa gaccttgaat tcggtaccgg cggaatgcgc ggggaaatcg gcgccgggac 956521 aaatcggatg aatatttaca ctgtgcgcaa agcatcggcc gggtttgcgg catacatctc 956581 gaagcaaggt gaggaagcga aaaaacgggg cgttgtcatt gcttatgatt cccgccataa 956641 gtctccggag ttcgcgatgg aagcggcaaa aacacttgcg acacaaggca tccaaacata 956701 cgtgtttgat gagcttcgcc cgacgccaga gctgtcattc gctgttagac agctgaacgc 956761 ttatggtgga attgtggtaa cggcaagcca taacccgcct gaatataacg gctacaaagt 956821 atacggggat gatggcggcc agctgcctcc aaaggaagcg gacatcgtca ttgagcaggt 956881 aaacgcgatt gaaaatgagc tgacgatcac agtggacgaa gaaaataagt taaaagaaaa 956941 aggcttaatc aaaatcatcg gtgaagatat tgataaagtt tatacagaaa aactgacgtc 957001 catttctgta catcctgaat tatcggaaga agtagatgta aaggttgttt tcacaccgct 957061 gcatggaact gcaaataaac cggtcagacg cggtcttgaa gcactcggct acaaaaatgt 957121 aacggttgtc aaagaacagg aactgccgga ttcaaacttc tccactgtta catcgccgaa 957181 cccggaagag catgcggcat tcgaatatgc cattaagctt ggggaggagc agaatgcaga 957241 tattctcatc gcgacagatc ctgatgctga ccgcctcggc atcgcggtga aaaacgatca 957301 aggcaaatat acagtgctga caggaaacca aaccggagcg ttgctgcttc attacctgct 957361 ttctgaaaag aaaaaacaag gcatcctgcc tgataacggt gttgttctca aaacgatcgt 957421 cacaagcgaa atcggccgtg ctgtagcttc ttcattcggc cttgatacga ttgatacgct 957481 gacaggcttt aagtttatcg gtgaaaagat taaggaatac gaagcatcag gccagtatac 957541 cttccaattc ggttatgaag agagctacgg ttatttaatc ggggattttg cccgcgataa 957601 ggacgccatt caggctgcgc ttttggcagt tgaagtttgc gcgttctata aaaaacaggg 957661 aatgtcattg tatgaggcgc tcatcaatct ctttaacgaa tatggttttt atcgtgaagg 957721 gctgaaatcc ctgacgctga aaggcaaaca aggagcagag caaattgaag cgattcttgc 957781 ttccttcaga caaaatccgc cgcagaaaat ggcgggcaaa caggttgtca cagcagaaga 957841 ttacgctgta agcaaacgga cgcttctgac tgaaagcaaa gaagaagcca tcgacttgcc 957901 aaaatcaaat gtattgaaat acttcctgga agacgggtct tggttctgtc tccgtccttc 957961 tggaactgag ccgaaggtta aattttattt cgccgtaaaa gggtcatctt tggaagacag 958021 tgaaaagcga cttgccgtcc tttctgaaga tgtaatgaag acggtggatg aaattgttga 958081 gtcaacagca aaataattca agtatgagct gggtcattgt aaatgatccg gctttttctt 958141 tttctcatcc aaaagtctga aagaaaatca tcctacaagt gaagcaatga aatacaaaaa 958201 actggtataa tcttaaatac aagatcaatg ccggagtgag aaacgtgagc aaaacgagga 958261 tggaaaaatt aaaaacgctg aaaacgattg cggaaacctt aaatcaaggg cacgatatca 958321 aagcaacact ggatgaggtt ttaaaagagt tgctgagtct gacaaacctt caatccggat 958381 ggatttttct gatcgaagaa gatgggtctt atacgttagc ggccgacgct tatctgcccc 958441 cggctttaag ccgcaaggaa aaagtgctga tgtgcgaagg ggagtgttac tgcctgacga 958501 aattcaataa cggagggctt agaaaagctg caaatatcat gaactgcaaa cgcatcgaat 958561 cagcagaaaa cctgcattgt tttgacacag aagggattac gcatcatgca actgtgcctt 958621 tagaagacgg ggacagaaga ttcggattgt taaatgtagc ggcggccgga aaaaccatgt 958681 ttgatgagga agagctgcat ttactcgagt ctgtcgcctt tcagatcgga acggcaatcc 958741 agcgtatgag gctttctgaa tatcaacaaa aaaatgctct tttaatggag cgtaaccgcc 958801 tcgctcagga gcttcacgat tcagtcaatc aaatgctgtt ttccgtcagt ttaactgcca 958861 aagctgcgaa gacactaaca aaagatgaaa atttacagca gatgattgat ttcatccaaa 958921 acctatcaca ggacgcgctc gcagaaatga aagcgttaat ttggcagctt cgccccggag 958981 gattggaaaa agggctggct gaagccatta aaagctatgg tgcgctcatt ggattgaaga 959041 tcatttttac acaaaaaggc tgtcctgttc tgactgatga gcaggagcat atgctatggc 959101 gtgtcgtaca ggaagcttta aataactgca aaaagcatgc cggaacggat acggcgtatg 959161 ttagtctgac tgcttctttg tgccatgcgg agctggatat catcgatcat ggggcaggat 959221 ttcgctatga agcgcatgcc ggtctgcctt cacttggcat aaaaggtatg aaagagcgag 959281 cggaaaaagc cggagctaag ttttggattg agtcagcgct tggaactgga acaaagctgt 959341 ccatcaggct tccgctaaaa agccgaaaag gaggggcggt atgaaaattg tcattgctga 959401 tgatcatcat gttgtcagaa agggtctgcg ttttttcttt gccacccagg atgatattga 959461 agtcgtcgga gaagctgcaa ctggattaga agccctccgt gtcatcgaag agacaaagcc 959521 ggatcttgtg ctaatggatt tgtctatgcc cgagatggac ggcattcaag ccattaaaaa 959581 agcaatacag caatttccgg atacgaatat cattgtgctg acgagctact ctgatcagga 959641 gcacgtcatc cccgcgcttc aggcaggcgc gaaggcgtat caattaaagg atacggagcc 959701 cgaggaattg gtgaaaacac gacaagtgca tggtggcgaa tacaagcttt ctacagctat 959761 tatgccccat gtgctgacac atatgaaaaa tcagcacgac ccggaaaaag aaaaatacta 959821 tcaattaact agaagggaaa aagacgttct gactgaaata gcgaacggga aaagcaataa 959881 agaaatcgca gcagccttgt ttatttcaga aaaaacagta aaaacccatg tatcgaatct 959941 tttagcaaaa cttgaagtgg ccgatcgcac gcaagcagcg cttttcgcag tgaaatataa 960001 cctgaatgga gagatctcaa aatgaacatg ttagtcataa atggcacgcc aagaaaacat 960061 ggcagaacaa gaattgcagc atcctatatt gcagctctgt atcacacgga tttgattgat 960121 ctaagcgagt ttgtattgcc cgtttttaac ggtgaagcgg aacaatctga actgttgaaa 960181 gtacaggagc ttaagcaacg cgttacgaaa gcggatgcga ttgtattatt atcgcctgaa 960241 tatcacagcg gcatgagcgg cgctttaaaa aatgccttgg attttctaag cagcgaacaa 960301 ttcaaatata agcccgttgc attattggca gtagcgggag gcggaaaagg cggcatcaat 960361 gcgctgaaca atatgagaac tgtgatgcgg ggtgtctacg ccaatgtcat tccgaagcag 960421 ctggtgcttg atccggtgca tattgatgtt gaaaatgcta cagtggctga aaacattaag 960481 gaaagcataa aagagcttgt cgaagaactc agcatgttcg caaaagcagg aaatcccggc 960541 gtctaaacgc cgggatttgt ttatgtgaga agggctattt gatcttcata agtcagctct 960601 gtggcatgat caatatatcg gagaagggaa tacagcatct tttctaaaac ggcgtaatcc 960661 tgttcaaaat gatacgcatg cagaaaatgc tcaattcgtt ttgataacaa atcgtcctct 960721 gtacgcacca ttaaaattaa taaattatcc cattgagaac gatgggtgta ataaagcgct 960781 ttatcgtaat cggcataatc catgaatcgc ttctcctttc ttgggtgaga agttcatgat 960841 tagtttatgc cgcatcctct gttattgacg gggcaaaact tgccgtctgc gtcagtaaag 960901 gggtagcaat atgagggaga cataaaatca aaatgcctga atgaagatat cgcttttggt 960961 aaacctatga gggaatatat tctgggtaca ggagactgaa aaaatgaaat ccctgccgta 961021 taccatcgca cttctttttt gcggattgat tatcgtgtca atggctgcaa aaggtcattc 961081 aacggacaca gacgagtccg ttcaaaagtg ggaacagctt gcctggagca aaattcagga 961141 tgaatataag ggcgcttcat tttctgatta tgcttatatg gggcgtacag aggtgaatga 961201 tcagcagact aaagatgtct ttcgggtgac agtcagacag aaagatgaca ctttttctgt 961261 tcgggccgaa gtctattttc atccggtgac aaatcatatg atcagcatca acgtctttag 961321 gctctaataa aaaactgtac agccgttaag gccgcacagt ttctgttttt agaaatatcg 961381 ttttgcaccg agatagcgct gtttccagta agagttgttc atattggaaa tgacaactcc 961441 ggaatcgttg gcatttatga attccccgtt gcctaggtaa attccgacgt gggaagggcc 961501 ggctttatat gttgaaaaga aaacgaaatc tccgacagca ggctggctaa ctgatttcat 961561 tgtgttccaa tatcccgctg ccgttaatct agatacggat gtgactttgt tcagtacata 961621 gtaaatgaat ccgctgcagt caaacccgga cggtgtcgtg cctccccagc gatacggaac 961681 cccaagctgc gctttagcgg ccgaaatcat tgtgttaatc ttcgcactcg ttgagctggt 961741 ggtgtttgaa gaaccggatg aagacgatga tgaagctttt ccggaaatga ccagcttttg 961801 gccaacctgc aagacatccg tttttaaatt gtttttctca cgaatctgct gagctgttac 961861 attaaatttt tgagcaatca cccataagga atcaccgctt ttcaccgtgt atgtagtcgt 961921 cgtgccggag cttgcatttg acgaagaaga cgacgatgat gaagagcctg aagatgcttt 961981 acctgtcagc ttcaatactt gtccaacgta aagcacatct gatttcagat tgttgatatt 962041 tcggatttgc tgtacagtca ggttatagtt gtttgcgatt ttccaaagtg aatcaccgct 962101 tttaacggta tatttagttg ttgctgaagt ttggttcgat ttggatgaat tgtctttaga 962161 agacgtatca gagccgcttg attttgtttt caacacctga ttcacgtaaa tggtgtctga 962221 ttttaagttg ttcaagacct tcaattcagc gatggacata ttgactttgt ttgcaatttt 962281 ccaaagtgaa tctccaagct gcaccttata tgttcccgta gaagatgaag aacttgaact 962341 cttattagaa ctgctttttg aactggagct tgaactctta ttagagttgc tttttttact 962401 ggaactagag cttgaagaaa cagtaccgga cacctttaat ttctgcccag cacgaattaa 962461 atcgctgctt agtccgttta attttttcag ttcctgcacc gtcattttaa actcatttgc 962521 gatcagccaa agtgaatctc cgcttttcac tgtgtaaaca gaacttccgc tcttcttggt 962581 tgttgagctt gaagtagatg aagaagtgct ggatttgctg cctggaatag taagcgtctg 962641 gccgatcgac agaacagtag tcgaaagatg attggcggat gtgagggccg ccacacttgt 962701 gttataggtt tgggccagtt tccataaaga atctccgctt ttgaccttaa tcgttgctgc 962761 ttcagctggt gtcactacta aagttgtgcc gacaatcgca gatgctgtca gccctgctgc 962821 taatttcttt ttcatcttag ctctcctttt tcccccaatg attttgcatt tgctgtttct 962881 tttttatatc ggcacatttg tctcatcgtt ttgccttttt ataaaaatag ccaaattatc 962941 ttaacaataa gggggaaaaa gggcataaaa aaagaaggaa tcttaatcta ttccttcatt 963001 tttaaaagct tcatgatatc ttctttgttt ttgacgaggt cgcgcagtgt gtatttgtct 963061 aaaactgcga ggtaggctaa aagcgcttca ttcagcacat gttttaagcc gcaaaccggg 963121 gaaataacac agagattctt gttcgcatca aaacattcaa caatattaaa atcgtcctcc 963181 gtttttctga caacctcacc gatgttgatg tcttcagggt ccatgcctaa tcgtatgccg 963241 ccgccccgtc cgcgtatcgt ttctacgtag ccgagctggc cgagcctgta tatgactttc 963301 atgagatgat tttttgaaat agaatacgtt tcggcaatct gttttatatt tgaaagttct 963361 ccgggacgct ctgcagccag aaaaatcaac actcttaatg aataatctgt ataattggtt 963421 aacttcataa taagacctca gaataagaca ttttctatat cttatcataa tcgattgaaa 963481 aatgaaaaaa aaggaattaa aaaacatgca cccagctggg tgcatgtttt ttgcttacat 963541 gtcattcggc ggattttggt ttttacggtt tttttcgatt tctgtgtttt gcattttgcg 963601 ttcaaatgta gacagataac gtgatgcaaa atccttaccg ccaaggccga aggataaacc 963661 aaaagcaagt gcgaagccgc taagaacgat gatgaacgcg gaattgacga ttgtcgcagc 963721 gacacccagc tgatccaggg ccataaagaa agcaagtgcg ataatcgtat atttagcaat 963781 aggcgctaaa gacttgaatt cctgaccttt tatcatgctt gcgagcactt ttctcaccaa 963841 ttctcctgcg taaaggccga gtccgagaat gaatactgcg acaaggacat tcggcagata 963901 cgcgatgatg ccggtggcaa tttctacgag gaagtgcagc cgaacaattt gaagcgcctc 963961 agctgtaaag agcagaatga caatgatttg cgcaatcata ccgacaactt gagacaagga 964021 cagctttgca ggcgttccgg cttccatgcc cattttccct aagacagaat caaagcctgc 964081 gcgatggagc agtccggaca ccatggattt cacccatttt cctgcccaga tacccgctaa 964141 tacaagcacg atggcaatca tgatgttcgg aagcatgttt aaaatcgtat tcagcataga 964201 gacagctggt tttgaaatgc cggcgacatc cagctgatca agcgctgaaa tgaccaccgg 964261 aatcataatg agcacataag cgattgttcc gatgactgct gaaaggcttg tgtcttttaa 964321 gtaaattgat aaacccatac gtgccgcgaa tctttcggtg ccgatgcttg caaggaaatt 964381 cgtaatgata tcacggacaa ggcgggcaac aagccatccg attaatacga taagcgccgc 964441 tgcaaataat ttcggcagaa aagcgagcac gctttccatc atatttgtaa aaggacctga 964501 aatgccgctg attttcaaag aagataagac ccctggcaga aaaacaagca gcacgagata 964561 aaagacaatt tgtgaagcgg tattgacagc ctggtgaata tcttttcctt cagacaccaa 964621 attccacttg cgcagtttgt cactcgtgtt cagcttcatc ccgatttttt tgacaaggaa 964681 gctcaaaaca gaagctgcag cccatcctaa cagcagaatg agtccggctt tcagcacgct 964741 tgggatcgca gctgcaatcg ccgaaagcat actgacaaac ggcgatgcca ctgttgtcag 964801 gtgcaaaatg ttaaagaata aaataaagac gatgatcagt gcgataaaat aaacgacctt 964861 gcttatgact ttttccgagg aatagcgtga aggctttttc ccagcaaaga gcttgtcgtc 964921 gatttttgtt ttgctgagtc ctttgtatac cgctttttca atgattttag caatagccca 964981 gccgattaat aagacgagta aagcaatgat tacgtttggc agcttactga gataagaaga 965041 aaacacgtct gctacattca attggtatcg ctcctttttc gtagtatggt gtgtgtttac 965101 ccacttatcc aataagcaaa cagatgaatg tgccggggga attttttctt gcccgagtga 965161 gactatcatc ttttgtctgg cgggctcata cattatagat aagtccaagt aggggggatt 965221 cggttgaacg cggaggagaa gaagggatta cagcgggcaa ttgaggaaat taccgaaatt 965281 gcaaaaggat tcggccttga tttctacccg atgagatatg aaatctgccc ggctgaaatt 965341 atttatacat ttggcgcgta cgggatgccg acaagattca gccactggag cttcggcaag 965401 cagtttcaca agatgaagct gcactatgat ctagggttaa gtaagatcta tgagctggtc 965461 attaactcag atccatgcta cgcttttttg ctggacagca actcactgat ccaaaataaa 965521 ttgattgtcg cacacgttct tgctcattgc gatttcttca aaaacaactg ccgtttccaa 965581 aacacgaagc gcgatatggt ggaaagcatg gcggcaacag ctgaacggat aaaacactat 965641 gaacaggttc acgggataaa agaagtcgaa tcttttttag atgcaatcct ttcgattcag 965701 gagcatatcg atccgtcgtt ggtccgacca aagctccaat ggagtgtgga tgatgaggaa 965761 gaggagattg aagaggcagc cacgccttac gatgatctat ggtctttaga tgaaaagaaa 965821 ccgaaaaaac aagtgaaaaa atcgaaaaaa ccgttcccgc cgcggcctga aaaagatatc 965881 ctgcttttta tcgaggagca ttcccgggag ctggagccat ggcagcgtga tatattaacg 965941 atgatgagag aggaaatgct ttatttctgg cctcagctgg aaaccaagat tatgaatgag 966001 ggctgggctt cctattggca ccagagaatt atacgtgagc ttgatttaac ctctgatgaa 966061 gcgatcgagt tcgccaagct gaatgcaggt gtcgttcagc cgtccaaaac aggcattaat 966121 ccttattatt tagggctgaa aatatttgaa gacattgaaa agaggtacaa caacccgacg 966181 gaggaaatga agaaaatggg cgtgcagcct gactccggcc gggagaaaat gtttgaggtc 966241 agggagattg aatccgatat ctctttcatc cgcaattatt taaccaaaga attagtcatg 966301 cgcgaggatc tttatttgtt tcaaaaacag ggccgagatt ataaaatcat cgataaacag 966361 tggaagtcgg tgcgcgacca gctcgtaagc atgcgggtaa atggcggttt tccatatttg 966421 acagtaaacg acggcgatta tatgaaaaat aacgaactct atattaagca ttggtatgag 966481 ggcatagagt tggatttgaa atatttggag aaagtgcttc cttatttatt ccagctttgg 966541 ggaagaagcg tgcacattga gtctgtgctt gaggataagg aagtcatgtt ttcgtacgac 966601 ggaaaaggtg ttcaccgcag atatttataa aaaagaggat gcagcgttct gcatcctttt 966661 tattttccag tttttaaaat cttaaatatg atgtttgcct ggtccgtatt gttaatcaat 966721 ccgcggaatt tttcttttcc ggggccgtac gcgtataccg gtacttcttc gccggtatga 966781 tcggtactcg tccatccgct gttggagcgg gtattaaaaa tcttgatgat ggctttggag 966841 gcccctttgc ttttgtcagc ctgtgcagct gcttcaacgc ttttgatttc ttcagatgtg 966901 actttcagat tggcatagcg ggcgagcaca tctttaaccg gcttgccttc actgattttt 966961 ttggccatga attcaggtgt tttcttagcg gagagaatcg gttctgcgtg ccaattcttt 967021 tccccgtttg cgccaatggt aaagccgccg gttgtatggt cagcagttgc aatcacaagt 967081 gtatgtttgt cttttttcgc aaattcaatc gcggctttat aggcctgttc aaaatcttta 967141 acctcgctca tggctcctac tgtatcattg tcatgggccg cccagtcaat ctggctccct 967201 tcgaccatca agaaaaatcc ttttttattt tggttcaggc gatcaattgc tgaaaccgtc 967261 atgtctttga gagacggtgt tttactgtca cggtcgagcg ctttagcaag ccctccatct 967321 gcgaaaagcc cgagcacctg ctgatcttta ttttttttca atgcttgttt agttgtcaca 967381 tagctgtagc cggcttgttt gaattccttt gtcaagtttc tgtccttgcg gttaaaataa 967441 gattttccgc cgccgagcag cacgtctatt ttatgtttgc cttttatctt gtcatccata 967501 tagctgttgg cgatttggtc catgtttttc cgtgattcat tgtgggcgcc atatgcggct 967561 ggagtggcgt ggttaatttc agacgtggcg acaagccctg ttgacttgcc ttgctgtttg 967621 gcctcttcaa gtacagattt cacttttttt ccgtttttat cgacgccaat tgcattgtta 967681 tatgtcttaa cgcctgtcgc taatgctgtt ccggctgctg ctgaatctgt aatattatag 967741 tcagggtcat ccggatgcgt catcatcatg cctgtcaggt tccggtcaaa ttctgttaac 967801 ttcgggttat tcggtgtgtc accgttattt ttcatggaac ggtaggctct tatgtaaggc 967861 gtccccatgc cgtcgcctat catcacaatg acatttctga tctcagcttt gtcttgtttt 967921 ttggcgctgg ccttttctgt ttgctgaagc tcagctccgg caaagattcc agctgtaagg 967981 acagaaacag cggcgattgg cagaagtttt gatttcatat tttgaaacaa actcattttt 968041 ttcatgcctc ctttaatgta ttccgtttat catgttaggg aaactttgtt aaatgcggct 968101 gttgatcatg taaacaataa gtaaagcctt gtaaggaaat gaaaaaacgc ttttcgttat 968161 cttgccttat ttgatgtaaa gcattcattt ttcagaaaaa tctttacctc tctgtctttg 968221 catgatatgt ttgtttaaat aaaaaaactg cggataacca cagctctcct cgaatatact 968281 ttatcactca tttttccgat atatgagccg accccgaaag tttttcattt atttccttta 968341 tgttgaaaaa catcccataa aacatgacaa aagcactcgt tttttgtcac ctttgcaatg 968401 aaaatgaaat atttaatacc cttaaaaact tttttttaga acgaataatt aagaaatttg 968461 tcacatgaag tcaagactat ttctgatggg aatctatcct tataatagaa atcaataaga 968521 ttaatttaaa aaaagagata catatatata gagttaacat ttggggagga aaatatgaaa 968581 aagcaaatca ttacagctac gacagcagtt gttttaggat cgacgttatt tgcaggagcg 968641 gcatctgcac aaagcattaa ggtgaaaaaa ggcgacacgt tatgggatct ttcaagaaaa 968701 tacgacacaa cgatcagtaa aattaaatca gagaaccacc ttcgttcaga cattatttat 968761 gtgggacaaa ctttatcgat taacggcaaa tctacaagtt caaaaagcag cagttcttct 968821 tcctcttctt ctacatacaa agtaaagagc ggggacagcc tttggaaaat ttcaaaaaaa 968881 tacggcatga caatcaatga actgaagaag ctgaatggct taaaatcaga tttgcttcgt 968941 gttggacaag tcctgaaact gaaaggttca actagttcaa gcagctccag ctcatcaaaa 969001 gtgtcatcgt cttcaacttc tacttataaa gtgaagagcg gagacagcct ttctaaaatt 969061 gcgagcaaat acggcactac ggttagcaaa ttaaaaagct taaacggctt aaaatcagat 969121 gtaatctatg tcaaccaagt attgaaggtg aaaggaacaa gcacaagcag ctcaaaacct 969181 gcttcatctt catcgtcttc aagcagcaaa acgtcatcta catcacttaa tgtgagcaag 969241 ctggtttctg atgcaaaagc gttagtcgga acgccatata aatggggcgg aacgacaact 969301 tcaggctttg actgcagcgg attcatttgg tacgtactga ataaacaaac aagtgtgggc 969361 agaacaagca ctgcaggata ctggagttct atgaagagca ttgccagccc gtctgttggt 969421 gatttcgtct tcttcacaac atataaatcc ggcccttctc acatggggat ttacattgga 969481 aacaacagtt tcattcatgc aggatctgac ggcgtacaaa tcagcagcct gaacaacagc 969541 tactggaagc ctcgttacct cggtgcgaaa agattctaat ttttagagaa aacccgttca 969601 ttggaacggg tttttttcat tagacggagc acaggcgttt tggttgctcc taaaaatgaa 969661 aatgtgataa aaaatccaag aacttttttt ctttcttatt ttcataaagg gcaatcgcgt 969721 aagcgccggc atagggcagc tgtacagact gataaggaat tctgatcatc tgtttctctg 969781 ctaactcacg ctttactgta gataaaggca gaaatgaaac tccgagtcct tccttgataa 969841 accgtttcgt tatatgtgtt tgagtgacct tcattgttct cacaaatgga aatgtcattc 969901 tgacttgacg gagcaagtcg tcccagtaat caggatgatt gtgggtcaaa agcaggtatt 969961 gttcgagcac ctctttggca tcaatttcgt tgtcttctat gaaacgctta tcgggcgggg 970021 caacaaggac gacagggtct ttgtataagc agtggcagct taaagaagaa gactgtacct 970081 ttaaacagct tagtccgata tctgcttccc cggctttaat cagtgacgcg atttccgctg 970141 attcgaaaat cgtaaccgcc atttctgttt ccgtattcat tgctgtgtac cgcttcatga 970201 cagaaggaag cactgtatct gcaataagcg gagaaaccgc gagctgtaag gtttgagagt 970261 agccttgtct cactctgtga agctctgcca tgctgttttc ataatcatca agaagcctga 970321 gcgcatacgg caaatacgcc ctgccttcat cagtcagctg gatttgcctg cctttacgct 970381 cgaacagctt gcagctgatt tctttttcta attgcttgat atgtacggtc acagtaggct 970441 gagataagaa aagcgtttcc gccgtttttc ggaagttctc atattttgca gcggtcacaa 970501 aggtgtgaag ccatttgaaa tccatttcta ttctccctct gattaatatt tttaattaat 970561 tccctttaaa atattgatta ttttttaaat attatattta ctataataac agaaaaggat 970621 agggggaata caaatggtac attacggatt aaagggaatt acatgtgtag aaacatccat 970681 cagccatatt gatggtgaaa aagggcgtct gatttacaga ggacatcatg caaaagacat 970741 cgcactgaat cacagctttg aagaagcggc ttatttgatt ttatttggaa aactgccttc 970801 aactgaagaa ttgcaggtat ttaaagataa gctggctgcg gaacggaatc ttccggaaca 970861 tattgagcgc ttgattcaat cactgccaaa caacatggac gatatgtcgg tgctgagaac 970921 ggttgtttca gcattggggg aaaatacgta cacattccat ccgaaaacag aggaagcaat 970981 ccggctgatt gcaatcacgc cttctatcat tgcatacaga aaaagatgga cgcgcggtga 971041 acaagcaatt gcaccttctt cccagtacgg acatgtcgaa aactactatt atatgctcac 971101 aggtgaacag ccttcagagg caaaaaagaa agcgcttgaa acctatatga ttctggccac 971161 ggagcacggc atgaacgcat cgactttttc ggcacgagtc acgttatcta cagagagtga 971221 tttagtgtca gccgtcacgg ctgctctcgg tacgatgaaa ggtccgctgc acggaggtgc 971281 tccttctgcg gtgacaaaaa tgcttgaaga cattggagaa aaggaacatg ctgaagcata 971341 tctgaaagaa aaactcgaaa aaggagagcg cttgatggga ttcggccaca gggtgtacaa 971401 aacaaaagac ccgcgggcag aagctttgag acagaaagca gaagaggtgg ccggcaatga 971461 ccgtgatctt gatcttgcgc tgcatgtaga agcagaagcg attcgtttgc tagaaatcta 971521 caaaccggga cgaaagctgt acacaaatgt tgaattttac gcagctgcag tgatgagggc 971581 catcgatttt gacgatgaat tgtttactcc gaccttttca gcaagccgaa tggtagggtg 971641 gtgcgcccat gtactggaac aggcagaaaa caacatgatt ttccgcccgt cagcgcaata 971701 taccggtgcc attcccgagg aagttctttc ataacatatt ttggcgttta ttcatttctg 971761 tcgtgtggta acgttcagta tcaaccacat gtctaggagt gatgaatgtg aacccaatgg 971821 acagacaaac agaaggacaa gaaccgcagc atcaggacag acagccgggc attgagtcaa 971881 aaatgaatcc gctgccgctg tcagaggacg aggattatcg aggaagcgga aaactgaaag 971941 gaaaagttgc gatcattact ggaggcgaca gcggaatagg gagagcagca gctattgcct 972001 ttgctaaaga gggggctgat atctccattc tatacttaga cgagcattcg gacgcagagg 972061 aaacacgcaa acggatcgaa aaggagaatg tccgctgcct gcttatcccg ggagatgttg 972121 gggacgagaa ccattgtgaa caagctgtgc agcaaacagt ggaccatttt ggtaaactcg 972181 atatcttagt gaacaacgcc gctgaacagc atccccagga cagcattctc aatatttcaa 972241 cagaacagct ggaaaaaacc tttcgcacaa atattttttc catgtttcat atgacgaaga 972301 aagctttgcc tcacctgcaa gaggggtgtg ccattattaa tacgacatcg attaccgctt 972361 atgaagggga tacggcgtta attgattatt ccagcacaaa gggtgcgatt gtttccttta 972421 cgcgttccat ggcgaagtcg cttgcagata aaggcatcag agtgaatgcg gtggcgcccg 972481 gtccgatttg gacaccgctt attccggcga cattccctga ggaaaaagtg aaacagcacg 972541 gcttggatac cccaatggga agaccgggac agccggttga gcatgcaggc gcctatgttc 972601 tgctggcgtc tgacgaatct tcctatatga cagggcagac cattcatgtg aatggcggcc 972661 gttttatttc aacgtaatca acgaaaaacc agctcaagag ctggtttttt gtgtggtgaa 972721 aaatttcaaa ataaaaaatt tgtcgatttt tctaacaatt ttgttttcat ttttgcaatt 972781 ttatatataa tattgagtag gagaaaggaa tgattcgcga ccagtacaaa tatagtagaa 972841 aaaaaagaat aatgaccatt gttactcatg aattcagaaa attcaaataa aatatataaa 972901 aatagatgat cgggagttga aggggaatga aagggagcgt ttttaggaag aaaagcattc 972961 aggatttaat cgctgcgacg agcggggaaa agtctttaaa aagagaatta ggggcatttg 973021 atttaacgtt gcttggaatc ggcgccatta ttggcacagg gatttttgtt ctgacgggaa 973081 caggcgcagt cacggccggt cccgggctga cgatttcatt tgttgtggcg gcgttggctt 973141 gtttattcgc cgccctgtct tacgcggaat ttgcgtcaag tgtgcctgtt tcaggttcgg 973201 tgtatacatt cacttatgcg acattgggag agcttatggc ctttattatc gggtgggatt 973261 taattttaga atacatgctg gcggtaagtg cagtgtcggt cggctggtct ggttatttcc 973321 aatcgttttt atcagggctt ggcattcatc ttccggttgc tttaacagcg gcaccgggcg 973381 cagtgaaagg cacctttacc ctgtttaatc ttcctgcatt cgtcattgta atggcgatca 973441 catatttgct ttatttaggc atcaaagaat caaaaagagt caacaatatc atggttatct 973501 tgaagatact ggttgttctg ctgtttatcg cggtggcagc cgtttacgtg aagccgcaca 973561 actggcagcc gtttatgcca atgggctttg gcggcgtgtt cagtgcagcg gcgctcgtat 973621 tctttgcttt tatcggattt gacgctgtat cctctgctgc ggaagaaacg aaaaatcccg 973681 cgaaggatct gcctaaaggc attattttct ctttactggt ctgcacgatt ttatatgtca 973741 ccgtatcagc catcatgact ggggttatcc cgtttgctca atttgcgggt gtggatcatc 973801 cggtttctct tgttcttcaa agcgcagggc aaaattgggt ggcaggcatc attgatattg 973861 gcgccgtgtt gggaatgaca acagttatgc tcgtgatgct ttacgggcag acccgcgtca 973921 tgtttgccat gtcgcgtgac ggacttgtgc cgggttcact ttctaaagtg catccaaagc 973981 acaaaacacc ttatgtagcc acttggtttt tcggaacgat gtcggcgctt ctcggctcac 974041 ttgttccgct ggatgaactt gcaaagctgg tgaacatcgg gacgttgtcg gcatttgtcc 974101 tgatttctgt ggcagttatc gttttgagaa agaaacagcc tgatcttccg agagctttta 974161 aatgcccggg agttcccgtg atcccaggcc tggcgattct gttctgcctg ttcttgattt 974221 taaatctggg atgggtgacg attgtccgct tcctagtgtg gctgttaatc ggcttggtaa 974281 tctatttcct gtattcaaga aagcattcaa aattaaatca ataacctttt gataaagaga 974341 gcggccatac aggccgcctc ttttctgttc ttggcaaatg aatctataga aatgaagaca 974401 aaaataagag ataatatagg ctggaaagga agtgacgttt attgtctgag caaaaaccag 974461 tccaatgggc ttcgaaaatt ggtttcgtca tggcagcggc cggctcggct atcggcttgg 974521 gcgcgatttg gaagttccct tacgtagcgg ggaccaatgg gggaggagcc ttttttctta 974581 tcttcgtgtt atttaccatc ctcttaggct atccgctttt ggtgggggaa tttatttttg 974641 gaagacggaa ccagacgaat gccattgatg catataaaaa agaagcgccg cgatcagctt 974701 ggtttcttac ggggtggatc ggcgtagcgg cgtgtttctt agtgctgtcg ttttacagtg 974761 taatcggggg atggattttg ctgtatatcg tgaaaacagc gtcaggatca ctgtccgggc 974821 tttctcaagc acagtatggc gctctttttg cttctattat ccaaaatccg gtgcagacgc 974881 tcgcggctca gcttgtcttt atggcactga ctgtactcgt tgtcgcaaga ggggttcaaa 974941 aagggattga acgggtaagc gcggtgatga tgccgatttt gtttttattg tttattctgc 975001 tcgttcttcg gtctcttacg cttaatggtg caatggaagg cgtaaagttt ctgcttgtgc 975061 ctcatttcgg cgatctgact ccggaatcca tattattcgc gctgggacag gccttcttta 975121 cgttaacact gggggtttcg gtgatggtga cctacagctc ctatttgccg aaaacacaaa 975181 atatccctcg ttcggcagcc tccattgtct tgatgaatat cattgtgaca ctcttggcag 975241 gtttggctat ttttccggcg gttttctcat tcggttttca gccaaatgaa ggaccgacat 975301 tgctgtttac agtgcttccg gccgtttttg aacagcttcc gttcggcaca ttgtttttta 975361 tcggctttct cgttgcattt ttatttgcag ccttaacctc agcattttcg atggttgaaa 975421 ttatcgttgc cacaatcgga aaaggggacg aaaagaagag aaaaaaactg tcatggacga 975481 gcgggctttt gatctttttg gtcggaatcc catgctgctt gtcttatggc gttttgagtg 975541 atgtgcacct atttggcaaa acgttttttg atattgccga ttttaccgtc agcaatgttt 975601 tgatgccttc aggcgctctg ttaatttctc tatttatccc gctgaaaatt tcgaaaagcg 975661 aactcttggc tgaaatgcga aatggatcaa atgcaggtaa agcattcttt tacacatggt 975721 tttatttgct tcgttttatc gtgccgcttg ccattattat cgtgttctta aatttaatcg 975781 gaattttatc attttaaaaa acaggctccg tttccggggc ctgtttttta tttaataaga 975841 tgatatcaac ggtgcccatg ccgttttcag tttttggatg ccgagcctga tgtcctcttc 975901 tgacaaaccg ccataaccga ttaagacaga agtaaaaggc gtctgttcta tatatgaggg 975961 agacacggga tagagggtta caccgtggtc agcggctgct tgtattgctt cttcctcact 976021 tgctggaaac aaaaggcgca gcagaatgtg aagccccgag ttcttaccga gaatctcaac 976081 ggtgtttccc agttcagagc gaatggcttc taacaggaca gcgtgttttt ttcggtataa 976141 gcttctcatt ctatttatgt gtttttgcca ctctccggtt tcgatgaagt ctgccagtgc 976201 caattgcgag tgggcagaaa cggtctgctt cattaactga acattgtttt ggatcggttc 976261 catgagttca gggggcacaa tcatgaagct gagccgcaag gaaggcagaa gtgactttga 976321 aaaagtgccc agatatatga ctctgccatt cggatcaaga ccctgtaaag acggaatggg 976381 atggccgctg tagcgaaatt ctccatcgta atcatcttct ataatgaatg aatttgtttc 976441 tgccgcccat gccagcagct cctgtctgcg ggtaatcgtc ataatggtcc caatcggaaa 976501 ctgatgcgaa ggagtcgtat acatgagata aggattctga cggtagagct catccggcag 976561 gacgccttct gcatcagaac aaatcggagt gacatccatg tgatttgctt caaacatcct 976621 tcttgaacgg tgaaagcccg gttcttcaaa gccgattttt gtacctggct ttagcgaaag 976681 gcaaagattt tgcagaagca cggtggttcc tgcgccgatg ataatctggc cgggttcaca 976741 atttactccc cgagacagcc tgacgaatcg ggcaatcatg tgcctgagtt cgtattctcc 976801 ttgagggtcg ccagaggtgt gaaacgatcc ggaatagcga tcaagacttt ttactatgct 976861 ttttctccat gcgttaaagg gaaagagggt cggatcaacg ctgccctgat ggaagtcaat 976921 agcaggtgcg tttttttgat gtaatcccgg ctgtacagac tgctgaaaat ggtcaggagc 976981 tgtcgggaat cctggttcta cttccgccgc gaaccagccg attttcggct tgcttttgac 977041 atagccctca gcagttaatt gctcataagc tcgttctata gttgccgtgc tgacatcgag 977101 caagctggag agcctgcgtt ttgacggaag tcttgttccc tttgtgattc gcgcatgtga 977161 aatttcttgt ttaaaaaagg tataaagctg ttcatacagc ggtgttttgc tctttttatc 977221 aagaaacggc gtaatatcca tctcatgtct cctttgtagc tggcatggtc attttttctg 977281 atattggcta tttggcaaat gccatttatt agctatgatc attgtaacga aaggaaaggg 977341 gattgagaag atgatccata tgaaacaatt aacctcgaaa gaagaatggg ctgagtcgta 977401 tccgattatg agtgaattga gaacagaact ggatatagag acgtatttac aaaggcttga 977461 agcctgtgtg cagaaagaat cgtatatgct gtttgcctta tatgaaaata cagcaatcag 977521 agcgctgtgc ggggctctgc cgagagtttc cattcataaa ggagagcact tgtggattgc 977581 ggatcttgtt acaacggcac cttgccgatc aaagggatac ggcaaaatgc ttttggatta 977641 tgcctcagac tgggcgagaa aagccggact cggttttgtc agtctttcat ctggccttca 977701 gcgtaaagac gcacatcgat tttatacaga taaaatgggt tttactatag aaagttattt 977761 gttccgaaaa ccggtataac gaaaaaagac gcctgaaaag gcgtcttttt taaaagccaa 977821 actgtaaatt cgtatctaca gatacaatgg tatacacaca aataatcaca aagagattaa 977881 ggatgacgcc gagcaggcct ggacctgtgc gccctctctt gatgaagagt tcaacaacgc 977941 cgaacggaac ggcagccatg gcgaacggaa gcatttgata ggaataaaac gtgacgttgc 978001 tgataatggc caaattcagc aacagcaggg acagaaccgc tgtcccgaca gagatccagc 978061 cgaatacatt gtgttcttta aaaattctta ccagttccat aattccacct cgccgacatt 978121 cgctgatttt acagatttat ttttcagcat gcgctggatt tccttggttg gccctgtaac 978181 gaccgaaccg tatacattga caccgttttt ctctacataa tctaatcggt tatctacatt 978241 caggtctttc cgttttgaaa tgacctgagc ccatttttcg tgtttggaca tgaatttcag 978301 ggcgttgata aactgatcgc cattcgactt gccttttgta ttaagggcgg ccaagaactt 978361 tgaatccttt ccaggatagc caagaggttc tgtggaagct gtcttatttg tgtttttctc 978421 tgtttcgatt gcgttccaca aaaagctcac atcatagcct ttgaatttgt tatacacgtc 978481 ttttgtcgga tatgcacggt catatgaaag gtagacctct gataccgttc cttcaggcaa 978541 tgtgcttaac gttttttctg cttttgcggt cgtttgttca gacttgtttg aaggatgtgt 978601 aaagtaatgg ccggttttat tcacttctaa gtcatagtag tttactgccg gcgcttttac 978661 tttgttataa aacatttcaa cccgttcatt ccctacggca gccgtcttcg tgccaatctg 978721 cttttgcagc gggaattccg tattcattcc aaatagcttc acttggcttt tcagtccgga 978781 agtatcaaca agaacattcg gcatggtcag ggctacagtg actgcggcag tttccataaa 978841 ctcattgccg gtgctgtgtt ttccacccat tccgtaatag aggtagcttc ccagcgtaca 978901 aagcggcaaa atcatcaatg tcgaaatgac ggcaagcaca gaaattcgca aataagactt 978961 gcgtttgccg taggctaaaa tcgctttttg tttttcagga ctgatgctga gatcccaatc 979021 gttatcgtcc tctagttcgc tgtcaatcag ttcctgatat acttcaagct tctcgagttc 979081 ttcctcaaat gcagtcattt cctggtcgct catttcccca tttttatatt gatcaaaacg 979141 ctttttaaat tcttcattca tcattaacac ctctattata aagtgctttc agccgctgtc 979201 tggcacgaaa taaaacactt ttaaaattcg cctctgaaat attcataata tgggatgctt 979261 ctttgtagtt taactctttt aaataatata gcgttaaggc ctcccgataa ttatcgggga 979321 gctcggacat ataaccagtc agcacttcct ttatctctac ctgatgggca ggactttgaa 979381 cagcattttg aaagaggctt ccgattaagt catcagaaat ggttacttct ttcttatgct 979441 ttctgacgta atcaatgaag gcgtttcgcg ccacttgaaa aagccagggc tttactttgc 979501 tgtgatcata ggagtgaatg tgtatgtatg cccgcataaa ggtttcctgc agtaagtctt 979561 cagcaagatg cttgtctttt gtcatggaga gcaggaacct gtaaacatca ttcatgtaca 979621 tttggtaaat ttcatcgatc gtcactgcct tttctcccct ctatgttata cacgcataag 979681 aaaggtttaa agttgcacat tacatgcaaa cggctttttt atacctaatc aaacaccatt 979741 actatatagt acccaaaaat ggccgcaaaa gatagtgcgg agaaaggttt aacatttttt 979801 ccagagggga aaagatagtg aaaaagtgaa ggagtggcac aatggaatat accagtatag 979861 cagatacagg aatagaagcc tccagaatcg gcctcggcac atgggccatt ggcggaacga 979921 tgtggggagg cactgacgaa aaaacatcga ttgaaacaat ccgcgccgct cttgatcagg 979981 ggattacact gattgacacc gcaccggctt acggcttcgg gcagtccgag gaaattgtcg 980041 gaaaggcaat caaagagtac ggcaaaagag accaggtgat tctcgcaacg aaaacggctc 980101 tggactggaa gaacaaccag ctgttccgcc atgcgaacag agcgagaatt gtagaggaag 980161 ttgagaattc tttgaagcgg cttcaaacag actatattga tctttatcag gtgcattggc 980221 ccgatccgct tgtgccaatt gaagaaacgg ctgaagtcat gaaggaatta tatgatgcgg 980281 gaaaaatccg ggcgattggc gtcagcaatt tttcaattga gcaaatggat acatttcgcg 980341 ccgtcgcacc tctccatacg attcagcctc catataatct gtttgaaaga gagatggaag 980401 agagtgtcct tccttatgcg aaagataaca agataacaac attattatac ggcagtttat 980461 gcagagggct gttaacaggc aaaatgactg aagaatatac atttgagggc gatgatctgc 980521 gtaatcacga tccaaaattc cagaagcccc gctttaaaga gtatctttct gctgtgaatc 980581 aattggataa gctggcgaag acacgttatg gaaaatcagt gattcacttg gctgtcagat 980641 ggatcttaga tcagccggga gcggatatcg ctctttgggg agcaagaaag cctgggcagc 980701 ttgaggccct atctgagatt acaggctgga cgctgaacag tgaagatcag aaagatatca 980761 atactatatt ggaaaatacg atatcagacc ctgtcggacc ggagtttatg gccccgccga 980821 ccagagagga aatataacaa aagctgaggg cgaatcctca gctttttggc gtttaaacga 980881 gagaaatctt aaaaattagt accaggtaat aaaaaatatt gttataatag atgacagaaa 980941 gaatcattga ttacgacaaa ggaagtgcga tatgtataag ttttgtgcaa atgctttaaa 981001 agttattctt tctcttcgcg gaggagtgaa ggtgtataac aaagaaaacc ttccggccga 981061 ttcaggtttt gtcatcgcgt gtacacattc cggctgggtt gatgtgatta cactcggagt 981121 cgggattctt ccttatcaaa tacactacat ggcgaaaaaa gagctttttc aaaataaatg 981181 gatcggttcg tttctgaaga aaattcatgc ctttccggta gatcgggaaa atcccgggcc 981241 aagcagtatt aaaacgccga ttaagctgct gaaagaagga gagatcgtcg gtatcttccc 981301 aagcggaaca agaacctctg aggatgtgcc tttgaaaaga ggtgcggtga cgattgcgca 981361 aatggggaaa gcgccgcttg tccccgctgc atatcagggc ccttcaagcg gaaaagaatt 981421 attcaaaaaa ggaaaaatga agctgattat cggtgagcct cttcaccagg ctgattttgc 981481 ccacctgcct tcaaaggaaa gacttgcagc aatgacagag gctttgaatc agcggattaa 981541 agaactagag aataaacttg atcagctata aggcgttctg agagattgtc ctgaaactgt 981601 gaaaataaga aaagcaccct atacaaggtg cttttcttat tatgcttcct gctggttagc 981661 tgtctccaga agttcttctt cttgaagctt tttcacttca atatatgcga cgtggtggcc 981721 gtcaatttca ttaatgatga attcgcagcc ctcttcgatg atggaatcat ctttttcaac 981781 atcgtatttt tgagtaagga accagccgcc gattgtatcg acttcttcgt tctctaaatg 981841 gatgcctagc aggtcgttta cttggtcaat taacactttt ccgtcaagaa tataatggcc 981901 ttcgccgatt ttgcggattt cgctaatttc atcaatatca aattcgtcgc ggatttcacc 981961 gacaatttcc tcaatgatgt cctcaaccgt cacaagcccg gcagtaccgc cgtattcatc 982021 agacaaaatg gccatgtgga ccctctcttt ttgcattttg acaagcaggt cttggatcgg 982081 cgcagattca atgacatgaa tgatagggtt gacgaattga gaaatggtgg aatcaacaga 982141 tacctcaccg ctgatgcagg cggtcagcac ttctttaatg ttaataaccc cgataatgtt 982201 atctttatcg ccctcttcca cagggtagcg ggtatatttt tcaatctgaa tgatgtccat 982261 catttcagaa atcttgatat catgcggaag gctgacaatt tcggtccgcg gaatcataat 982321 ttctttcgcg agcctgtcgt caaattcaaa gattttattc acatatttaa actctgattg 982381 gttgatttca ccgcttttat agctttcaga caaaatgatt cgcagctctt cttctgagtg 982441 agccagttcg ttttctgaaa cggtctccag gccaaatgct ttggtcaata accgtgcgga 982501 attgttcaaa agccaaatga atgggaacgc gatgcggtaa aaccaaatca gcggtttcgc 982561 aaacagcata gacactgctt ccgccttttg gatagcgact gttttaggtg caagttctcc 982621 gacaacaacg tgtaagaacg tgataatggc atacgcaaaa ataaacgata tgacatgtga 982681 aagggaacct ggaacgttca tttggacgaa aagcgggtga agcagccttt cgatcgttga 982741 ttcacctaaa acccctaatc cgatggaagt caatgtaatt ccgagctgac acgcagataa 982801 atattcatca agatgcgtgg tcactttttt tacggctatt gctgctttat ttccttccgc 982861 gatcagctga tcgatccgtg agcctctgat tctgataatg gcaaactcag atgccacgaa 982921 aaatgccgtc agggcgatta aaacagcaac taaaatcaaa ttcactatgt ccaattagaa 982981 ccttcactct agcaatgaga atgaaggtaa cacctcctgt tagataaaat ggttttaact 983041 taacagcagc ataaatgatt ggaacacggc gagcttttca ggcgggagtt tgcttttcag 983101 cttgtcacga tcctcgggct tcagccgttc aaaccgatgc aagattccgg agatgttttg 983161 attcatatga tcaatttcta atgccagatt tccaatttca tcatcaagtt tagctgaaga 983221 gggaaactgg ttctccagtc gatctttaat atcggacagg gccaatcgct gcttcttgca 983281 atctacaata aatataagtc gtttgagtgc attttcgtcg tagtaacggt aatttgaaca 983341 ggatctggcc ggcgtaagca gaccgagatt cgtataataa tcaactgtcc gtttcgttac 983401 tccggcgagt gccgctagtt cactgatgcg ataagtctca gccccatcta tatccctccc 983461 aaccatcacg ttatagttat gagaatagtt taatatatga acggtgtctt gcacaagttt 983521 attgtttttt ttagaccgga attggaagtt gtggaattca tcatctgatt gaagtaacat 983581 aggaagatag aattttcaaa tttttatatg cggaagggac agatgaaatt ggctgggtta 983641 tcccgggaag ttgaagaaaa cttaaataaa ggatcatgga ttcgcaagct gtttgatgaa 983701 ggtgcaaggc tgaagaagga gttcggggaa gaccaggtat ttgatttttc actcggcaac 983761 ccgattgttg aaccgcctga agcttttaag agagcgttaa tagaggaagc tgaaaaaggc 983821 agccacggat acatacaaaa ccaagggctt cttgcagcga gagaaaaagt cgcgcaattt 983881 ctgggctcgc gttttgaagc tgatttctca gcggagcgca tcgtcatgac ggtgggcgcg 983941 ggaggcgctt tgaatgttgc gttaaaaagc atcgtaaacc ctggggaaga ggtcattatt 984001 cttgcacctt attttgccga atataagttg tatattgaga actacggggg aaaagccgtc 984061 agctgcccgt tgacaagccg gtttgagatc gacattgaag cggtaaggca atcgatcact 984121 ccacagacga aagggctgat tctcaataca ccgcataacc ccacaggcac tgttctcagc 984181 cagaaaaata tagacgattt aggcgcttta ttaaaagaaa tagaagagaa gagcggccag 984241 acgatttatg tgctgtttga tgaaccgtac agtcaattaa tctatgatga agagctggca 984301 aatccgtttc aatcgtacca tcgtgtgata ttggccagct cattcagtaa agatctcggc 984361 atagccggag agcggctcgg gtatatcgga ttggacagcc gaatgccgga tgcggacctt 984421 ttgatcaacg cttttgtgta ttgtaatcga acgcttggat ttgtgaatgc ccctgtcatg 984481 atgcagcggg ctgtggcacg aatggatgat ttaagagtag acgcgagcgc ttataaagag 984541 cgccgggatt taatggtaga cattttaaaa gaagccggtt ttgaatttga aatgccaaag 984601 ggaggtttct ttgtttttcc gaaatcgccg attgaagatg aagttgcatt ttgcgtgcat 984661 gccgcccaaa aatacaaatt attaattgtg ccgagcagcg gttttggaat gagcgggcat 984721 ttccgattat ccttcagtgt gccgatcgag cagattaaaa actcacggga cattttcatt 984781 tctttatata aagattttgc ttaagaaggc aaagaaaaga aaacagtttt caaggctgtt 984841 ttctttttat atccgcaaaa tccttcctct tccaatccag acaggcgcag aattgacaag 984901 caggcatgca gttaaggctt tcttcatgat aaaagtctaa aaattaaaaa tcatttttgg 984961 aatgagttgt gttacaataa aatatacaat ttataatcaa actttgactt ttggaggtgg 985021 tatgatgggg ccctctgctt aggcaacaat acaccgcgta cctcaatgtt aaggaaaaat 985081 gattatatca ggaggtgact ccttatcctt tgttgagagg atagggttaa atggacgata 985141 ttgacagtct gattttaatt ggcgtgctca ttgctttaac cgcgtttttc gttgcaagcg 985201 agtttgcgat tgttagagtg aggagatcca gaatagatca gcttatcaca gaaggaaaca 985261 aacgggcgat actcgcaagg cgtgtcatta cagatttgga tgaatattta tccgcatccc 985321 agctaggcat tacattgaca tcaatcgggc ttggcgtact gggtgagccg gcctttgaac 985381 ggctgctgca tccactgttt gaaccgctcg gcttgccgga ctcggtttca catgcagtct 985441 cttttgcagt cgcgtacggc ttgatcacgt tcctgcacgt tgttgtaggt gaactggccc 985501 cgaaaacggt cgcgattcaa aaggcagaac agctgacttt actgatagcg ggccctttgc 985561 gtttattcta tttgctcctg tttccgttta tttggatcct caatggatcg gcgcggcttt 985621 tatgcgggat gttcggtttg aagcctgcgt cagaacatga tggttcccat tctgaggaag 985681 aactcaggat gctgttatct gagagtttaa aaaacggaga gattaatccg tctgaatata 985741 aatatgtgaa taagattttt gaatttgata atcggatcgc caaagaaatt atgataccgc 985801 ggaaggaaat ggctgctgtg tcaactgaga tgacgatggc cgagatgctt gaagtcatgc 985861 tgaaggaaaa atacacgcgc tggccagtca cagatggaga caaagacagt gtgctcggtt 985921 tggtcaatac gaagcatttg ttttctgatt tgctgtttat gacagaagaa gaacgaatga 985981 agatgacgat ccatccgtat gtgaggccgg tcatcgaagt gattgaaacg atcccggttc 986041 atgacttgct gattaaaatg cagcgcgagc gcattcatat ggctatattg tcggatgaat 986101 acggaggaac ctcgggactt gtgacgacag aggatattct tgaggaaatt gtcggagaga 986161 tccgagatga atttgatgaa gatgaacagc cgctgatcca aaagcttggc gacggccatt 986221 atgtgatgga tggaaaggtt cggatcgatc aggtgaacag ccttcttggc gcatcgattc 986281 aagaagacgt cgatacgatc ggcgggctga tattaaaaga aaacatcgat attgaggctg 986341 gtgaatccat tcgcatcggt tcatatacga taaaggtgct gaagatggac ggccgattaa 986401 tcaagcaaat cgatataaaa gaagaagccg gcaacacaac cgggattacg gcgcaccaca 986461 agctgccgct gcccgagcct gtgatgctga acagtgcaac cttgagcgag aaataagctc 986521 aaggtttttt tatattgtga ttgtccagcc gcaccaaaat gcaaaaagcg acccgcaaag 986581 tgtcaggacg atgtacaaga tgctttcttt tacacgtttg gccataagga gttgaatagt 986641 ttcaacgctg aatgtggaaa aggtcgtaaa ggcgccaaaa aaccccgtgc caatgataag 986701 cgagaccgaa gcatttgcaa cgtgaagtcc tgtaaatatt ccgagcccga gagctccgag 986761 aatattgact gtcagtatgc caatgggcag gctgagacct ttggttttgg cggttatgac 986821 attgccaagc cagaagcgaa gcattgcgcc aagtccgccc cctatgaaaa tacccgctag 986881 tgtcattttt cctgcagccc ctttctttgc tgaatgcctg ctatgcgccg tcccacaaaa 986941 acaccaatca gtgcaaatat gatccctgat atcaatgagg ctgccacata taaaagagcc 987001 aatgagggtt gtccttgcaa aagcatcact gtttccttag aaaacgtgga cattgttgtg 987061 aagcctccgc aaaagccggt gcctaaaaaa gccgacagca gaggccgttt tgccccgatc 987121 ataaaaaatc cggtcaaaat gcctaataga aggctgcctg ccgcattttc cagccaggtt 987181 gccgccggga actgaccggt gtgtatccat aagtttaatc cgtatcggag gcaggcgcca 987241 agcgcgcctc cgataaaaac cgcgctatat attttcatgt ttgccatcct ttatgatgaa 987301 atccgggtaa tctgtaacga tgccgtccac gcccatggct tgtaattttg ccgctgtctt 987361 ttgattgttg acagtccatg caaatatgtt taagccattt ttattgatgg agccgatcat 987421 cagacggtta agccgtgtgt gttttatatt gacatagttt gcaaaagagc ggaaggcctt 987481 catctgattt ctggacagca tgccaaagtt gggccttgta atgaccgctg tcggaatcga 987541 aggataaagc tcgcggaacc tttggacgga gcggaactga aaggattgaa caatattatt 987601 gatagaaaaa gaaaattgcc ctaatagctg tcccacctct tcttcaattc cgacttgaga 987661 cggatggcct tttagttcaa ttaaaaggcc gatttttttg tggtagcgct tgagcaccgc 987721 ttccagggtt ggaatacgct ctccttgaaa agcgggaccg taccagcttc ctgcatcgag 987781 tttttgcaat tcctccaagg taaaatcctt aacaaagccc gatccgtttg ttgttcggtc 987841 aaccctgtca tcgtgtatca caacaatctg cctgtctttt gtaagctgga catccagttc 987901 gatcatatct gcattcattt tcaccgcaag gtcaaatgcg gcaatcgtat tttccggagc 987961 gtagccggat gctccgcgat gggcaatgat gtacaagcta agtcagctcc tcgtatgggc 988021 atttctgtta ttgtatcaaa tccatatatg caccgcgata caaactggtg aattttttct 988081 gccatatcgg aatggtccgg gctgaggaat gcgtataact aaaaaaagac actcagcgta 988141 tcagaacaca tttcgtcaga aaattaggtc tttcgacatg ttcacaacaa aatatgatcc 988201 tttataatag caaaaaagga ggcgagatca tgggaaaagg gagaatcaga gtggaggaaa 988261 gaattaaagc cgaaacggat gctgaaatgc aaaaagcaac tctccttgat cagacacaaa 988321 cgaaaaaagg taagtgactg tccctattga atctggctga tagatgaatt gagaaatgac 988381 cccggcgttt cgccggggtt ttgtgctgca taagacattt aaatgaacat ccttacgaat 988441 attttagtat aataaacaat tgattgggat agaggggaga cagtcatgcc ggattatctg 988501 cagcagtatt ttacgcttga taacatcata caaatcggca tcagcttggc gattttgctg 988561 gtgtttctta tacttagaaa attattcaca agatattttt ttaacctgct ttttaatttg 988621 acaaaccggc cgaaaacaga aatttttaaa caggtggttc tggcgtttga taagccggcc 988681 agatggtttt ttgttgccct tgggctgttt ttagcgatcc ggtattcacc gtttttagat 988741 gagcaaatgc cggtcatcag caaaatatac cgctcactga ttgtggcgct cttgtgttgg 988801 ggtctttgta atttgaccgc aacatcgtcg tttatcttcc ataaggtgaa ccagcgcttc 988861 gagcttgaca tggatgacat tctggccccg tttttatcca aattgctccg ttttgtgatc 988921 attgcgctca gtgtcagtgt gatcgctcag gaattcaatt atgatgtcaa cggatttgta 988981 gcgggccttg gtcttggcgg actggctttt gcgcttgccg cgaaggatac catcagcaac 989041 ttcttcggcg gtattatcat tattactgaa aagccgttta caattggtga ctgggtggag 989101 acgtcgacag taacaggatc agtcgaggat attaccttta ggagcacgag attcagaaca 989161 gcacaggggg cgcttgtaac ggtgccgaac tctacgctgt cgatggaagc gatcacgaac 989221 tggacaagaa tgaccaaacg ccagattacg ttttccatcc atgtgtccta cgctacgccg 989281 attgagaacc ttgaacgctc cattcattct ctcagaacaa tgctcttaga gcatgagggc 989341 gttgataatg aaataatcat ggtcaacttt gatacgtttg ccgacagcta ctacaattta 989401 ttttttaact tctatacaaa aacgacggtt tgggctgaaa accttaatat tagagaggat 989461 atcaactata aaattattga gattttaggt gcagaaggcg ttcagtttgc atatcccggc 989521 caaatggttg ttgtcaagca aaagcacgaa agcgaccaat tccaggtgaa tctaaataaa 989581 gaggaaaagg aacgggctta aaagagagac ttcgtctgac agaggcggag tctttttcat 989641 ggtaaaataa gagaaaaagg cggtgttgag ttggaaacat tcaaaagtat tctacatgaa 989701 gcacagagaa ttgttgtgct gaccggagcg ggaatgagca cagaatcagg gatccccgac 989761 tttcgttcag cagggggcat ttggacggag gatgcctcaa gaatggaagc gatgagcctt 989821 gattattttt taagttatcc gcgtctgttt tggcccaaat tcaaagaatt gttccagatg 989881 aaaatgagcg gcagctttga accgaatgaa ggccatttgc ttttagctga gctggagaag 989941 caagggaagc aggtcgatat tttcacgcaa aacattgacg gtcttcataa aaaagcgggg 990001 agcaggcatg tgtacgaact gcatggttct atccagacag cagcttgtcc ggcatgcggc 990061 gcccgatatg atcttcccca tttgctggag cgggaggtgc cggagtgcac ggcggccgga 990121 aacaatgggg acatttgcgg aacggtatta aaaaccgatg ttgttctctt tggcgatgcc 990181 gtcatgcact ttgacaccct ttatgaaaag ctggatcaag cagatctttt attggttatc 990241 ggcacgtctc tcgaagtggc tccggctaga tttgtgcctg aggatgcaag cctgattccc 990301 ggcatgaaga aagtcatcat aaaccttgaa ccaacgtatt gcgacagctt gtttgacatg 990361 gtcatccatc aaaaaatcgg cgagtttgcc cgaagtttgg gcatgaaaaa gtgagccgct 990421 ttatgcgcct cactttttta ttcatgaaca ggaaccattg tgtcctctaa cactccgaag 990481 gaatagcctt tttcttttaa tttattgatt agtaccggca gcgcatttac agtagcagga 990541 agatcatgca tgagaattac atttgggcgg cttgaagagc tgtgttccat attctcaagc 990601 tgctgtaata cggcggtcac atactgtgaa ttccggtatt tccagtccat gctgtcgatc 990661 gtccaatccc agtacacaaa cccatctttc tccagattgc gaatttgtga ggcggttagt 990721 gacggcttgc ttccgtatgg cgttctgaca agatcggttt tatatcctgt aatgtcctgc 990781 agcgtgtcac gcgcctcctg catttctttt agcggagatg tcggtgtttg atagaacaat 990841 ctgttattgt gggtaacgcc atgtaaaccg agtgcgtggc cttccttttc tgctcttttc 990901 acagcctgct tgaattcgtt catccgcggt gacagcataa aaaacgtcgc ttttacatca 990961 gcgcttttca gtacgtcgag caagcgggtt gtaacggctg aagggccgtc gtcgaaggtt 991021 aagtaaaccg ttttatctcc catgttctgc tttgtctgca gatgttttat caggagatcg 991081 ggggagtcgt ttttcagctt aaggctttcc ttctcatctc gaagctggcc gtttgttgtg 991141 acagtgactt cctttgcttt cgttgaactg ttggaataac ccaaaatcac cataagcaaa 991201 agcagcacac ataaaactgc taaacttgca aatttaaaag caagcgaaac tgcagaagga 991261 gaagcctctc ctctcgtttg tcgcataaca atctctccat tggcataaaa tctctacata 991321 atgctgtaca gcaggcagct tatgaagatg ccttatgttt acaacctatg tattaccagt 991381 caagtataca ggaataaaac tggaaagcac atagaaaatt tgtcgaaatg tcagatttta 991441 aggaaaaaat aaactccttt ccgctataga tctcttgatc tttctgtttt tcagcttgtc 991501 caatatggta gaattagtga taatgacagc ttgaatgaca tcagggacat ctcgaaaagg 991561 gagggctttt atgaaggttt tagtcaatgg ccggctgatt gggcgcagtg aagcatcaat 991621 cgatttggaa gatcgcggtt atcagtttgg tgacggcatc tatgaagtga tcagggtgta 991681 caaaggagta ttgttcggct tacgtgagca tgcagagcgt tttttcagaa gtgctgctga 991741 aatcggaatt tcactgccat tcagtataga agatctcgag tgggacctgc aaaagcttgt 991801 acaggaaaat gcggtcagtg agggagcggt atacattcag acaacaagag gtgtggcccc 991861 gcgaaaacac cagtatgaag ccggcctcga gccgcagact actgcctata cgtttacggt 991921 gaaaaaaccg gagcaagagc aggcatacgg agtggcggcc attacagatg aggatcttcg 991981 ctggttaaga tgtgatatca aaagtctgaa tttactgtat aatgtcatga cgaagcaaag 992041 ggcctatgaa gccggagcat ttgaagccat tttacttagg gacggcgttg ttacggaggg 992101 tacatcctct aacgtttatg ccgttatcaa cggcacagtg cgaacacatc cggctaatcg 992161 gctcattctc aatggaatta cacggatgaa tattttagga ctgattgaga agaatgggat 992221 caaactggat gagactcctg tcagtgaaga agagttgaaa caggcggaag agatctttat 992281 ttcgtcaacg acggcagaaa ttattccggt cgtgacgctc gatggacaat cgatcggaag 992341 cgggaaaccc ggaccggtga ccaaacagct tcaggctgct tttcaagaaa gcattcaaca 992401 ggctgctagc atttcataaa tgaacgaaga aaagagcccg ctttttacag cggggctctt 992461 tttatttttt aacaaatcca atcaaaatgg agatcattgg cgatatatag aggaagaacg 992521 taaatgggat gtagtctatg actggaacac caagtgcgct cgccataaat gcgccgctga 992581 cgccccaagg aatcaatggg ttaattaatg ttccgccgtc ctctaatgat cttgtcagaa 992641 attttcgctg gatgtttcgt ttgtcatata aagatttaaa tgattgtccc ggtattaata 992701 tcgataaata ctgttcgccc gttgccaagt tgacgccgat gcttgagcag acagttgctg 992761 caacaagacg gccttttgag cggatgcctt tcatgacgcc ttccaatagt gcagaaatca 992821 atccgatttt ctccatcaat ccgccgagtg caaaagcaat cataatgaga gagacagagc 992881 ccatcatgga ttgcagtccg cctctgttaa taattttagc ggctgcctca ttgtcagttt 992941 cgaaagttgt gccattttgt aaagctgtca taaacgcctg caggctgctg tagggtacaa 993001 aaatagcagt caaaattccc gaggaaataa ttccggcagt cagaacgggg attactgata 993061 cccgtttcat tgccagcaaa acgactaaga gcggagaaag aagggcccac ggtgtcacgt 993121 ttgcagcatc ttttattccg gttatgacct gctgaatatt atcggttgaa gcagcgtccg 993181 ctgacactga tgaaccgaga aagtaaaaca gaacgacagt gatgagcaaa gctggaatgg 993241 ttgtgcccat catatggcga atgtgttcaa agattggtat ttcgcctatt ccggctgcaa 993301 agttggttgt gtccgacatc ggcgacattt tatccccaaa acaagcgccg catatgactg 993361 cgcctgctgt ccattcaagc ggaacgccag ccgcgctcgc cacgccgatc agcgctactc 993421 cgattgtgct tacagttgtc agacttgagc caacaagtgt gctgatgatc atacatgaaa 993481 acaaagcagt caacagaagg tggcttggtt caataaagga tagggcataa actgtcatag 993541 tcggtattgc gccgctgtac atccaggcgc cgattaagat gccgatcagc gctagaacaa 993601 taatcggctg tacgccgttt ttgatcccgt ctacaatccc tttttcaatg ctcttccagg 993661 gaaatccaaa ccataaagct gctgctgaaa gcatgacaac acttaaaaac agcgggatat 993721 gaggttctac atgaagcaag aataagcaag aaataataat gcacaacatg aatataaata 993781 aaccgacggc taacggaaac gtcagctttt tttgagaatc caaaataaca ccccatattt 993841 atctttaatg cttttgtgct tttgggcacg aaagcattat aacagaaaaa aacgaaaatc 993901 tatgtttttt cacaattatg aatataaaag aagtgagcac agggcgtgct cactttacaa 993961 tcaggacggg tatatccgat ttcgctgaaa gcttttcact tacacttccg aatattagct 994021 ttttcagcct gttttggtct ctgcttccgg ttacgatcat atcggcagaa atgcggtttg 994081 catgctcgat aattgattca gccggatcgc cttctaatat atcgatatct ccatctgcct 994141 gctgttcatt cagcatcatt ctggcttcgg cgatgacttc ttccgtacgg tcttcataga 994201 tcattggctc aggtgatgtt acatccgata tcagcggatc aggaacactt gtcatgcctc 994261 cgctgatata gcttgcctca gctgcgggtc tgggcgggtc gatgacggtc tgattgtctt 994321 tcatatcatg tgaatgggcg acggtaatag cggcatttac ggttttagca agatcaatgg 994381 ctgtcagaag cgctttctta ctattttcac ttccgtcaaa cgcaacaatg atacggtcag 994441 catggaacat ccttctcacc ctttcaaagc gtcttacaac actactaccc gaatttgagc 994501 acaattaacc ttttcctatt caagtaatga ttgacaataa aaggttttgt ttatatgatg 994561 ataaaaagat gaaatcagaa tggaaggagg gtttgctatg ccaaggaatt tgcgtgttta 994621 tcaaacagtt tcatattggc gcggcaaacc ttttgttctg ttttcgtgaa cggtttttta 994681 ggtcggaccg cgcgctgaaa agcgctgtgc gtaacatatc ggttaaaaaa ggcatggagc 994741 tgacgcttca tgcctttttt atatacaaaa tctaaggaaa gacaggtgta tgggatgtga 994801 agacaaatac agaggcgagg gcagttcgtg ccaaactgga tgaaaaaagc tgcaaggaaa 994861 aaatagaagg cggctgatga ggagatgggg atagatgttt tcagttttga aaaagcttgg 994921 ctggtttttt aaggcgtact ggctgcgcta tacgattgcg attgtccttt tattagcagt 994981 caatgtcatt gaaatgtttc cgcctaagct cttggggaac gccatagatg atatgaaagc 995041 aggggcattt actgcggaag ggctgctgtt ttatatcggt atcttttttg tgctgacggc 995101 ggccgtgtat atcatgtctt atttttggat gcatcagctg tttggcggag cgaatctgat 995161 ggagaaaatt cttcgtacga agctgatggg gcatttgctg actatgtcgc cgccgtttta 995221 tgaaaaaaac cgaacaggcg atttaatggc acgagggaca aatgatcttc aggccgtcag 995281 tttaaccaca gggtttggca tcttgacgtt agttgattct acgatgttta tgatgacgat 995341 ctttttgaca atggggtttt tgatcagctg gaagctgacc tttgccgcca ttatcccgct 995401 tccagtcatg gcgattgcaa tcagtctata tggaagtaaa attcatgagc ggtttactga 995461 ggcccaaaac gcgttcgggg cgctgaatga cagagtgctg gaatctgttt caggcgtgcg 995521 ggtgattcgc gcgtatgttc aggaaacaaa cgatgttcgc cggtttaatg aaatgaccgc 995581 tgatgtttat cagaaaaata tgaaagtggc ttttattgat tcactgtttg agccgacggt 995641 aaaactgctt gtcggcgcaa gctatctgat tgggctcggc tacggagcgt ttcttgtatt 995701 ccggaacgag ctgacgcttg gagagttagt gtcctttaac gtttatctcg gcatgatgat 995761 ttggccgatg tttgcaatcg gtgaactcat taatgtgatg cagcgcggca atgcgtcatt 995821 agatcgggta aatgaaactc tttcttatga aacggatgtg acagatccaa aacagcccgc 995881 tgatcttaaa gagcctggag atatcgtttt cagtcatgtc agctttacat atccaagctc 995941 aacaagtgac aatcttcagg atatttcatt tacggtgcga aaagggcaga ctgtcgggat 996001 tgcaggtaaa accgggagcg gaaaaacgac aattattaag cagcttttgc gccagtatcc 996061 tccaggtgaa gggagcatta cattttcagg tgtaccgatt cagcaaatcc ctcttgaccg 996121 tctccgcgga tggatcggat atgtgcctca ggatcattta ctgttttcac ggactgtaaa 996181 agaaaatatt ttatacggaa aacaggatgc aactgataaa gaggttcagc aagccattgc 996241 cgaagcacat tttgaaaaag atttgcacat gcttccgtcc ggtctggaga caatggtcgg 996301 tgaaaaaggc gtggcactgt caggcgggca gaaacaaaga atttcgatcg cgagagcact 996361 catggcgaat ccggaaatct tgattctgga tgattcactt tccgctgtag atgccaaaac 996421 agaggctgca attatcaaga acatcagaga aaaccgcaaa ggaaaaacga catttatttt 996481 gacacaccga ttatccgcgg tagagcacgc tgacctgatc cttgtgatgg acggcggcgt 996541 cattgctgag agaggcacgc atcaagaact gctggccaat aatgggtggt accgggaaca 996601 atatgaaaga cagcagctgt tcactgcgga agaaggggga gcaggggcat gaaaatagga 996661 aaaacgttat ggagatacgc acttctttat cgaaaattgc tgatcacagc cgtccttttg 996721 ctaactgttg ccgtcggtgc agaactgact gggcccttta ttggcaaaaa aatgatagac 996781 gaccatatcc tcggcattga gaaaacatgg tatgaagctg cggaaaaaga taaaaatgcc 996841 gttcagtttc acggcgtctc atatgtcaga gaggaccgat tgcaggagcc tgtttcaaaa 996901 gcaaaagaag cgcatattta tcaagtggga atggcgttct attttgttga tcaggctgtc 996961 agcttcgacg ggaatagaac ggtttctgac gggaagctga cgatcacaaa cggagacaag 997021 agccgggcat atgctgccga aaagctgact aagcaggaac ttttccagtt ctatcagccg 997081 gaaataaagg gaatggtgtt actgatctgc ctgtatgggg gcttgcttgt gttttcggta 997141 ttctttcaat acggacagca ttatctgctg cagatgagcg ccaatcggat tattcaaaag 997201 atgaggcagg acgtgttttc gcacatacag aaaatgccga ttcgctattt tgacaacctt 997261 ccggccggaa aagtcgttgc gcggattacc aatgatacgg aggctattag ggatttatat 997321 gtcacagtgc tttcaacatt tgtgacaagc ggaatctata tgttcgggat attcacggct 997381 ttgtttctgc ttgatgtgaa gcttgcgttt gtatgtctgg caattgtgcc gattatctgg 997441 ctgtggtcgg tcatataccg gagatatgcg tcatattaca accaaaaaat ccgctcgatc 997501 aacagtgaca ttaacgcaaa aatgaatgag tcaattcaag gcatgaccat tattcaggct 997561 ttccgccatc aaaaggaaac aatgagagaa tttgaggaat taaatgaatc acatttttat 997621 ttccaaaaca ggatgctgaa tttaaactcc ttaatgtccc ataatctggt caatgtcatc 997681 cgcaatcttg cgttcgtctg tctgatctgg cattttggcg gtgcgagcct gaatgcggcg 997741 gggattgttt ctatcggtgt gctgtacgcg tttgtcgatt atttgaaccg gttatttcag 997801 ccgatcacag gcatcgtcaa tcagttttca aagctggagc ttgcaagggt ctccgccggg 997861 cgtgtttttg aactgcttga agaaaagaat acggaagaag cgggtgaacc ggcgaaggag 997921 cgcgcgctgg ggcgggttga atttcgtgat gtgtcatttg cgtatcaaga aggtgaagag 997981 gtattaaagc atatttcctt tactgcgcaa aaaggcgaaa ccgtagcgct cgtcggccat 998041 accggatcag gaaaaagctc gattttgaat cttctgtttc gtttttatga tgcgcaaaaa 998101 ggtgatgtct taattgatgg aaaaagcatt tacaacatgt caagacagga actcagatcc 998161 catatgggta ttgtgcttca ggacccgtac ttattctcgg gcacaatcgg atctaacgta 998221 agtctggatg acgaaagaat gactgaagaa gaaataaaaa atgcactgcg gcaagtcggt 998281 gctgagcctc ttcttaagaa gcttccgaag ggcattaatg agcccgtgat tgaaaaaggc 998341 agcacgctat cctctggaga gcggcagtta atttctttcg ctagagcttt ggcgtttgat 998401 cccgcgatct tgattttaga tgaggcaacg gcgcatattg atacagagac agaggccgtg 998461 atccagaagg cgcttgatgt cgtcaaacaa ggacgcacca ccttcgtcat cgctcaccgg 998521 ctttcaacaa tcagaaatgc tgatcagatt ttggttcttg ataaaggaga aattgttgag 998581 agagggaacc acgaggaact gatggcatta gaaggccaat attatcaaat gtatgaactg 998641 caaaagggac agaaacattc cattgcataa cgctcaaaaa cccaaaacaa tcgtgttttg 998701 ggtttttggt ttatgtagtc aataagccag tccgacacgg tttccgacat actcacctgt 998761 aacgagctca cgatataaaa agtccgcagt atcgccgacc gaaatgcttg tgccgccctc 998821 aggcaaaacg ttacgctccg tacgataaac gccggttgct gttccgtccg ggaggtaagt 998881 ggggcagatg attgtccagt ctaatgatga ttctttaagc atttcgtata cttttgcatg 998941 ctccttggct gcgcgggtct gctttcgttt cgattcattt gtttcaaacc ggtattttcc 999001 cggttcatat cgggaatcta ggatccctgc ggtgccgatc gtaataagcc gtttgatatg 999061 ctgttcctcc ataacggaga gaatgtgtgc catagcagtt gacaaggtat catcaccatc 999121 tgtgcctaga cagctgatca cgatttcagc attctccatt atttttttca catcttctaa 999181 gcggcgggcg ttccccatga cagttctgtc ttttgaaagg ggaagatcag catgttgaga 999241 tctgatcaga gcgaaaatat caaatctttc atctgctgca gcttgtgtta aaaaggcttg 999301 tccgacgcgg ccgctggctc ctaataaagc gattttcatt aaaaaacctc ctcgcctttc 999361 attataaaag gatgttctca gtttgaacag cgcgggaaag aatacctgta caaataaaca 999421 gaacgatggg aaacatattc atgaatcatg gatacactta cgaattgaac cagctcccaa 999481 ttcacaatgg tgatgaatga caccccgatt ccctcccttt ttttctagga tatgtggagc 999541 aggaaaaaag ggtgacaaaa taaagagagc gcggaaaccg cgccctctat agccatatat 999601 tgaattgtta ttgaactctg ccgcccattt gctgctgagc gaaagatact aaacgttttg 999661 tgatttctcc tccgacagaa ccgttagcgc gagaagttgt gtccgctcca aggttaacgc 999721 cgaattcaga agcgatttca agtttcattt gatcgatagc ctgagctgcg ccaggaacta 999781 gtaagtcatt tgaagagttt tggttagcca tgtgtaaaat ctccttttta tttagtatgg 999841 ttgggttaac tggagttgca ccaatctgtg aacccttctc gggtgtcact gccgcctcgg 999901 cgtaacccaa tgctttgccg gcttgttact acgtattatg ttaaaatggc cggaaaatca 999961 tgcggagaat tgtgtggtaa atcttgagaa ataaaaaaag cttagccgtt taggctaagc 1000021 tagtcataaa tatgaaaaag catcagttca tgtatctcgt ttgtaagagc aggctcgtca 1000081 gcgcgggcgg gaaacaagtc tccccattca atctcaccgc tcttatgata gatgccttca 1000141 taatgggtcc ctttataata aaatgaaatt ttccatccgg gcagcttttc ttttgggaac 1000201 aaaggtttcc agctgaaatg agaaatcatt acggccacgc tccttacatt tggtatcaat 1000261 tgacctaaat aaaaacggct tatgttcatt gtatcattgt ttcagaacat cattgaagag 1000321 gcctaaatat gcagtttgtc ccagctttgg ataaagataa gcccgcttta ttaaaaaagc 1000381 ggacaggtta cgaaggccac aatgcttccg gagatgtgat tgccttctca gataaatatg 1000441 acgcgtattc aaaacttctt cgttttgtaa gagaatcaac atgatgcaaa tttggatgag 1000501 aaaaaatgct tcggcccggg cgcgaattcg cttcaaacat ccatacttta ccgttctgat 1000561 caatgccaaa atcgaaacca atctccccga taaatccctc gatatgatca tgaaggacat 1000621 ggcttgcagt cagtgccgct gcagaaagct ttttaatgac ctcaactctt tcagcgggat 1000681 catcgtatac ttccgcaagt gtctttacag tgccgccgtt agaaagatgt gttgtaatgc 1000741 tgttctttcc ggaaattttt acggcgattg ctgtcactgt ccattttcct tttctgtttt 1000801 tattggtatg gacacggaaa tccgctggtt tgccttgaaa ttcgatgaga tcaacacctt 1000861 gctgaatgag aaagtcggac gggttgtgat gtttttgaaa ttctgcaagg aatgaggcgg 1000921 catcggaata atcaattgat gtaaaagttt tggcgtcatt cgtatgcttt accgtcaggc 1000981 cgccatctgt tcttgtcagc tgataaatgc cggtgccgag tgctccattt gccggtttga 1001041 tatagacttt tttgtatgcg ccacagagct catctatcag ctccacagac ggtgtcagct 1001101 cggatctagg caaaaagggt gccgttcttg gatctttttc gagcaattga tgaacgttcc 1001161 atttattgaa aaacgtttta ttaaaccatg ggatctgata ttcatcgatc agcctctttt 1001221 ttgtatgttg caagagaagt gaatcttcaa tttttcggtt cggcaaacgg tcataaacga 1001281 cgttcggcaa tggaacgatt tttttctccc agccgttttc cctgtaaagg aggccttcaa 1001341 tcgtgccttc ctcccaattg atttggtgcg cgccaaaaac gaagcagtag cccccggctt 1001401 gctcgtgtaa cgtgacaagt ttagaaaaaa agagggaacg atccttaaat gggcgttcaa 1001461 gagatacagt aaaccctgcc gtaaagatgc cgactaacgg cccgatatgc actgtatgat 1001521 catgaatcag tatatctgcc ctgcttcggt ggggaagcaa aagctcatga aacagatttt 1001581 cagagagaag cacggtttgt tccagatgcc gtctgtaagc aacgtggcat ctgacaacct 1001641 tcgttccgaa tgcggcatgc aaaagtccgt cttgcttcag cgaagagggc agaaacaggg 1001701 tgttttcact ggttttgtct atgccgatca aaaaccgttt aggattcacg cggaagaact 1001761 cctttctggc tttgctcaga aaacagatat tggcagcgtt ttaggggaca agtgtacagc 1001821 tgttcttttt gctcgggaga gacacgcagg attgacttcc tgcctggttt ggaattgata 1001881 tctaaaatcc aaattctccc gtcctttgca agacatatat caagaccgag ttcaaacaac 1001941 ggcccatagc gctcgtcaag ataatacgga accgattggg taattgaaaa cacatcatct 1002001 agtaaaacca cttgctgttt tttcggtata tcttcaaacc aggagtcaaa tgtcagcgca 1002061 tcagatccgc ctgacaaatt ggccagcagc ccgtgtttgt atccgcgtct tactgccttt 1002121 ccgactgtat tccattcacc tgcttcgttt ttttccataa acagacgaat atcacaaggg 1002181 tattgttcct tatcttgaat gtttaagtaa ggctgaagca aatattgatg ctgaagcact 1002241 tttttgcacc atgttttaaa agaagtctgg ttggaaaacg tttttgtctg cttatccttt 1002301 ccgatgtgat aagtagcagt gatgtttttc ttgcccagct tcaaaagaat cacgcctctg 1002361 cctcccgcgc cgaatgccgg tttaaggatg caggcttttt ctttggataa aaaggagtga 1002421 atttgttcgt agcggctcac ctttatcgtt tcgggaatat agggattgat tacagagtgc 1002481 tgctgcaaat cgtgaaggac ggtccactta tcgggaagac cccgcccgat aaattccgtt 1002541 ttcggatatt ttttgagcca ctcaacgatt ggttttgctt tttgggaatg tgaatccttg 1002601 ccgtaaaaac agcgatcata aatataatct ggaatcgcca tttcagtttc gttccatgtg 1002661 ctgctggccg aatgatagac cgatgctttg acacgcaaag tgtcaggtga aatatcaaat 1002721 ggtgtaaacc ggatgaaacg tatgccgaat tcgggtgctc ttttggccag ttctgcggaa 1002781 taatccgctt catgctggcg ggataaggac ataaaaccga gtgttatcat ggtgagactc 1002841 ccccttttat tcaaaagctg ccggcgggtg tccgcagctt tacactaaat acatgtaaga 1002901 cgaacgcagc tgacggtatt ctactttaca gaatacgatt ctccaccttg ccctattcca 1002961 aaagaacaag ctgattttct aagaacagga atttgtctcc tcgtttgcta agtgattgca 1003021 tgagcctcta taatacgtat aggtacataa tctatatgaa aaaagctgaa gcacagatgg 1003081 aggaagatga ataggaatgg gtattgcagg aacctttatt tttatgatcg tgatcggcgc 1003141 tgccattgga gcggtgacca atcatttagc aattcaaatg ctgtttaggc cgtataaagc 1003201 gtactatttg tttgggaaac gagttccttt tacgcccggg ctgattccaa gacggcgaga 1003261 tgaacttgca aaacaaatgg gactgatggt agtcaatcat ctcttaaccc ctgaaggcat 1003321 taaaaagcgg ctcgtctctg atgcagccaa aacgcaggct cttcgagtgg gggaacagct 1003381 gattcaaaag ctgtcacttt ctgaagtgac agtaaaagaa gcgcttgaaa aagccgggat 1003441 gaagcgcccc gaaaaagctg ctgatgcatg gatcagcagc tggaccgatg ataagctgca 1003501 tgagcttttc cgccaatacg gggaccaatc gttaaaagag ctggtgccta tagaggtgca 1003561 ggaaaagctt gaggaaaaaa ttccgatgat ttcaggatat atattgtcac ggagtgtccg 1003621 ttattttgaa agtgatgaag gaaaaatccg tcttggcaat atgattgatg actttttaaa 1003681 agagcgcggc atgcttggaa gcatggtgca attgtttctt ggcaattcaa gccttgcgga 1003741 tcgcgtgctg ccggagctgc tgaaattctt gcgcaatgag gaaacaaata aattgctttc 1003801 tgatctctta aaaaacgaat ggggcaagct gagggagtat acgtttaatg aagcagatga 1003861 aaaatggaat gcaaaggcgc tcattttcag tttgaaacga agagtgctgc aagcattttc 1003921 gactgcccct ttcttcaaca atacgattgg cacgcttacc gtccgctatg aatctgagct 1003981 gacccagcaa atgctgccgg cactattaga caaattgctt gaaggtattt cgtccaacct 1004041 tgaaagtgtc ttaaaacggt tgcgtcttga ggaaatcgtc aaggagcagg tggatcagtt 1004101 cccggtggag cgtcttgaag aaatggtgct gtccatttca aaaaaagaat ttaaaatgat 1004161 tacctatttg gggggccttc tcggcggaat tataggcgcg attcaagcat tgtttgtcat 1004221 ccttttttaa gaagaaatgg tttttgatta atgaaaggag ctccatagtc tgttatagtg 1004281 gagtggtatg tcaaacggca atgatgaaag gagctattta caatggctgt taatttttat 1004341 gatgtagcgt atgatctgga aaatgcatta cgcgggagcg aagaattcac ccgtttaaaa 1004401 aacctttacg acgaagttaa cgcagatgaa tcagcgaagc gcatgttcga aaacttccgt 1004461 gatgtacagc ttagactcca gcaaaaacaa atggcaggag aagagattac acaagaagaa 1004521 gtgacgcagg ctcaaaaaac agttgcgctt gtacagcagc acgaaaaaat ttctcagctg 1004581 atggaagcgg agcagcgcat gagcatgctg attggtgaat tgaacaaaat cattatgaag 1004641 cctttagaag agctttacgg cagtgttgaa ggctaataag caaaatccct tcttggataa 1004701 gaagggattt tttattcact cagcaaactt ggaaatccaa tgaatctttt acctctccat 1004761 tgatgatgac tgataatgta tgaattcctt tgtaatgctt tctggtggtt aaatccttaa 1004821 aggattggat tcttgtgtat gacttcgttt cgttttttcg tatatttgtt tctgttattt 1004881 taaatacttt ctgatgacgc tggcctcttg cttttacaaa atcaattgcg tactcaattc 1004941 ttactttttg atccctgtct gaatgaatat agaaagaaaa ttcaaggctt tcgccaataa 1005001 ctatacgttt gggctggcat gttaaatcat gtagttgtat cgaatcagca ttttcataac 1005061 caaaaagcgc taaggcctgt ttatcaccct tttttaataa ggtccgatag gcgtgtttga 1005121 taatccagtc tgtatgggga tgtgttccgt accattgatc tgcgactttt ctcagtaaat 1005181 gaggatgcgt ttttgatata tcattaaggt tgttggccac gctttttctt acatataaag 1005241 actcgtcctg catcagcttc tcaaggatcg gcaatacggg ggaagggtcc gatttcaaag 1005301 ccggtatcga ttttccccat ggcaggcggg gcctgctgcc ttcgctcgca agtcttctca 1005361 cgtgttcatt tttatgctca gaccatgcaa gcaattgtgc aatcatcttt tcttgatcta 1005421 acagcaaaaa aggccttaca gcaaattctg aggtcgaata ttgcgtaaag gattccaatg 1005481 cctttattga ttcttcccaa tgcgctaacc cgtactgttc cacataatct ggaaataaaa 1005541 ttccgctgag tcctttaaaa tgaggggctg tatcccgtaa aattgtgagc gcttcaacgt 1005601 attgttttgg caaagtttcg tataaagaaa ctgtcacgcg gcgcatccgc tcttttaaag 1005661 tgagttcagg ccagtcctcc agccgtaatg tatccaagaa tctgtttttg ttaaaatcag 1005721 gataggatga ccttacatga tggatcaact gagatatcag ttcttcatta tatatttctt 1005781 ttaaatcagc catataaaca ccgctttttc gtttattatt tatattgtat gggaatgtac 1005841 gttctggatc aagtgtatag tcctaaaaat taacaactga tcctaccacg gatatacaaa 1005901 agttggttac tttttttagt taaaaaaacc cttgtcatcg gaaaggaaaa ctgagataat 1005961 aacattgaaa gcgcctacac ttacctattt caaatggata cggtcgcata tcatgccgtt 1006021 atatagaggg gataagcaac agagagtaag tgttcggagc gcatcattgg tcaaacaagg 1006081 ggttcctgat acatgatttt tcgtaaatcg aaataacgat attagggaga atggctgctt 1006141 cgatcgtatc ctatcaacaa gccatacata aagtctgctg agccaggctt tttttgcttt 1006201 aagaaaaggt tgttctaaac acagagacag ggtcatatcc tatacacaag tacagtcatc 1006261 aaggaggggg acatctctgt gtcaaaacaa ttgcttgcct taaatataga tggagcgctg 1006321 cttcggtcga acgggaagat tcatcaggca acgaaagacg cgattgaata tgtaaagaaa 1006381 aaagggattt acgtcacact tgtgaccaac cgtcattttc gctcagcaca gaaaatagcg 1006441 aaatcgctaa agcttgatgc caagctgatc acccatagcg gggcatatat cgctgagaaa 1006501 attgacgccc cgttttttga aaaaagaatt tctgatgatc atacctttaa cattgttcaa 1006561 gtgctggaga gctatcaatg caatattcgg cttcttcacg aaaagtattc catcggaaac 1006621 aagaaaaagg tgaattcgaa tttattaggg aaagcactca ttcatccgtc tgacccgatc 1006681 ttttatccag tccagttcgt tgaatcatta agcgatctcc tcatggatga gccggtgagt 1006741 gcacccgtca tcgaggtgta cacggagcac gacattcagc atgacattac agaaacgatt 1006801 acaaaagcct tccctgcggt ggacgtgatt cgcgtaaacg atgagaaact gaatatcgtc 1006861 ccgaagggtg tctcgaagga agcgggtttg gccctcgtcg cttcagagct gggcctgagt 1006921 atggatgatg tcgtggccat tgggcatcag tatgacgatc tgccgatgat cgaacttgcc 1006981 ggtcttgggg tagcgatggg gaatgccgtt ccggaaatta agagaaaggc agattgggtt 1007041 acaaggtcca atgacgagca aggtgtcgct tatatgatga aggaatattt ccgaatgcag 1007101 cagcgaaaag gatttcttga taagttccac atgaaacgtg tgtaaaaaag ccgctcgcgc 1007161 cctgacaggt gcggcggctt ttttgccgga ttgattttag cagtttattt ctgtacacta 1007221 aagaaagttt tgaatctgat aaattaggtg atgaagttgc aaattaaaat agaaggcata 1007281 catgatgacc gcctgcatcg gcctctgcaa aatattgcaa atttgtttta tgaagagtgc 1007341 gagcttgcgt atggcggaga ggagcccgca gattttgtca tttctttagc gttgtcacaa 1007401 acggatgagc atgtgacggt ttctggagaa gtgaagggta ctggcataaa ggaacagcat 1007461 acaaaattct tttctccaga catgactgaa aaagaagctt ttaagcaagt gaaaaacaca 1007521 atttcttatg tgtatctcaa tcttcttcag gcgcatacgg gcattacgca gaagtgggga 1007581 atcctcacag gaatccggcc cacaaagctg cttcataaaa aactgcaaag cggaatgtcc 1007641 aaggagcaag cgcatgctga gttgaaaaaa gactatttaa ttcatgatga aaaaatcatg 1007701 ctaatgcagg aaattgttga ccgtcagctg gcggcagtgc cggatttgta ccgagtaaag 1007761 gatgaagtca gcatttatat cggcattccg ttctgcccga caaaatgcgc gtattgcaca 1007821 ttccctgcgt acgctatcca aggacaggcg ggcagagtcg gctcattcct atggggactg 1007881 cattacgaaa tgcagaaaat cggtgaatgg ctgaaggagc atgatgttaa ggttacaacc 1007941 atttactttg gcggcgggac gccgacaagc attacagcgg aggagatgga tctgctgtat 1008001 gaagaaatgg tccgctcctt cccggatgtg aaaaacattc gtgagattac ggtggaggcc 1008061 ggtcgtcctg acacgattac agaagaaaaa ctcgccgttt taaacaaata tgacattgat 1008121 cggatcagca tcaatccgca atcctacgaa aacgaaacgc taaaggcgat cgggcggcac 1008181 catacggttg aagagaccat tgagaaatat catctgtcac gccagcacgg catgaataat 1008241 attaacatgg acttgattat tggtttgcct ggggaaggcg tgaaggagtt caggcacagt 1008301 ctttcagaaa cagaaaaact gatgccggaa tcccttaccg ttcatactct ttcatttaaa 1008361 cgggcgtcag aaatgacgag aaacaagcat aagtacaaag ttgccggcag ggaagaggtt 1008421 tctcaaatga tggaagacgc ggtagcctgg acgaaagagc atgggtacgt gccttattat 1008481 ttataccgcc agaaaaacat tcttggaaac cttgaaaacg tcggatactc tttgccggga 1008541 caagaaagca tctacaacat tatgattatg gaagaggtgc agacgattat tggcatcggc 1008601 tgcggcgctg ctagtaaatt tattgatcgg gatacaggga aaattacgca ttttgcgaat 1008661 ccgaaagatc cgaaatcgta caatgagcgc ttcgagcact acacggacga aaaaatcaaa 1008721 tatttagagc agatttttga aaaaacgaca aagcagcact gattacagtg ctgctttttt 1008781 tatccctgtt tttttgcggg ctgaacctca ggcttccatt taaatacctt gttcagcaag 1008841 cggtaaattc gttttgattc ctttgtgaca agcggtccca aaatcgccag aatgaggaca 1008901 tataatgcgg caaacggctt taatgtggcc gacagtccgc cggctatccc gagattcgca 1008961 acgataatcg aaaattctcc ccgcgatacg atcgtcagcc cgatattcga tgaagcctta 1009021 tgagaaagcc ctgcgcgtcg tcctgccacc attccggcga taaaatttcc cagaatggtc 1009081 aaaatcactg cacccaacgc aagccaaacc gcttcaccaa gcgaaaacgg atcgatgctg 1009141 aggccgaagc tgaaaaagaa catcgcaccg aagaagtcgc gaaacggaac aacgaggtgt 1009201 tcaatcctat cggaatgctc tgtttctgaa aagaccaaac cgagcagcag cgcgccgatt 1009261 gcttctgcta catgaatcgt ctctgaaaaa ccggcgataa aaaagagtgc tgcgaaaatg 1009321 acgataataa acacttcgtt tgagcgaatg tccaacagtt tgttcaacag cggcgggagt 1009381 tttcttgctg cgataaaaaa cagcagcata taaccgaagg cgatcaaaat ggacaagagt 1009441 gcactcccta cggatgtcgc atcacctagt ataaggccgg aaacaacgga cagatatacg 1009501 gcaaggaaaa tatcttcaaa catgatgatg ccgagaatca attcggtttc cgggttggcg 1009561 gttcttttta aatcaacgag cacttttgcg acaatcgcac ttgacgagat tgtgatgacg 1009621 cctgcgagga tgaggacttc cagaaaggaa aatccggtga taaacccgta aagcagtccg 1009681 aggctgaagt taatcaaaat ataaatcgtc ccgccgaccg cgattgattt tcctgatttg 1009741 attaacttcc cgacagagaa ttcgagtccg agatagaaga ggaggaacag tacgcccatt 1009801 cgcccgaaaa actcgatgat ttcactgctt tgaataaatg ttagatcaat aatccccatt 1009861 ttcggcgcgt gcggtccaac aagcattccc agcacaatca gaaacggaat aatcgaaaat 1009921 ttaattttat tggcgatcac actggcgatt gccacaagca caagtgcagt tccgacttca 1009981 aatacaagat ggtccatcgg ggctcacacg ccctctccag aaagaaaatc gtgaatcagt 1010041 ttcttcagat gctttctctc acctgagagg acaagggtgt cattttcttc aataatcgaa 1010101 tccgctccgg gatttaggag cttttcctgg ttgtgtttga taatcgcaat aacagtgaca 1010161 tcgtaattct ggcgaacatc aagctcaccg agtgtgcgtc cgatcgattt ggcgcctttt 1010221 tcgaccttaa accattcaat aataagatcg ctgaaggcca tttcgatgga ctccagagct 1010281 tgcggtttat agaccatgcc cccgagaata gctgcaattt gccttgcttc agaatcatcc 1010341 aatgaaatat ttgaaagaag ctcatccggg tcccggtcat taaaccggta aatttccctt 1010401 cttccgtcat catgaatgat aatcgtcatt ttttcgtggc ttcttgtttc gatttcaaac 1010461 tttttgccga tgcccggcag atcgttttct ttaatattca atgaaaatcc ctccgaatgt 1010521 agtgttggca gtatggggtg agttacaaat aaaacttgag caaattatat tcggaggtaa 1010581 ttagactggt atttgacagg gacggccaaa gccttttcca gcctgtttat cagcggttcg 1010641 tcaagtggtt tgacagagag ctgcctgaca gactgcgcca gcgggctgta ctctttgatc 1010701 agctcagccg ggtgcatgct gcccggcgat ggcgtttttg ccgattgtgt ttcctgcgga 1010761 tatgaagaca taggcacata gctgtcagtg cttgcttcaa actgggaagg cagaaccacg 1010821 tccgaagggg gaaagtacac cataaataaa cttaacagaa aactgatcag caatttatcc 1010881 atgttccttt cctcccttct catcaagata tcccttcttt ttcactatat aaaactttat 1010941 gtttccattc aaacaatatg catttttcag tatctattga ccttgaaaaa taaaaaggtt 1011001 tatttgggga tggcggggaa tgtataggag aaagaaaaaa gtaagcgcat acatggaggt 1011061 gcttttaatg gagtttgttc aatatgcatg taatggggcc gttgcagaga ttatcctgaa 1011121 tcggcctgat gcccatcacg ccctgaatga acagatgctg tctgaattga aggaggcagt 1011181 cgaaatggcg gctgcaagcg aggcgctcat cgttctcctg agaggaagcg ggaaaggctt 1011241 ttcggccggc ggtgatatca ggatgatgac gtcagagcat gaccctgacc aatttaaacg 1011301 gctgatggat acgattgagg ctgtcaccct gaatttatat cagatgaaga aagtgacaat 1011361 tgcagccatt catggtgctg ctgcgggact gggcctgagt ttggcgcttt gtgcggacat 1011421 tgtgctcgct gaaaaaaacg ccgttctcgc gatgaatttt atcggcattg ggcttgttcc 1011481 ggacggcgga ggacattatt tgctgaagaa aagaatcggt gaagcaaaag cgaaaaaact 1011541 gatttggagc ggaaaaaaac tatctgcctc ggaagctgcc gatatggggc ttcttgatgg 1011601 gacatttgcc ggagaccctg ccgaaggcgc aagacccatt atcgaaaccc tgttggcctc 1011661 ccctcttttg gcgatgatcg aaacgaaagg tatttttcaa agcctccaaa ttgaagaact 1011721 gaaaaaagtg ctatcccttg agcgcagcgc ccaagagaga atgagaagga ccaaggatca 1011781 ccaagaagga atccgtgcct ttttagaaaa acgggagccg aagtttcaag cgtaacagat 1011841 cagccggaaa gctgatcatc tgtgaaacaa aatcagcttt ccggctgcat tgactaaacg 1011901 atgagtatga ctatgaagct ctttttcttt taagagggct tcaccatgcg tttttgccgc 1011961 ttcttcatgt tctgcctcga attgctcgtt taccagcgtg ttccccgaag gatcaaatac 1012021 ggtaaggaaa taatcagcca tcaggtttct cctccatttt aaggtttatc agtctttctt 1012081 catttatatt ctaaaaagga aatcaaaatc ctttattatg ctttatccaa aattagtata 1012141 taatgggtca gggaaggagg agattcagtg cttacaattg atcacgtaac gaagacattt 1012201 ggagattata aagccgttga cggattggac ttagatattc cggaacagca aatgttcggt 1012261 ctattaggcg caaacggagc gggaaaaaca acaacgtttc gcatgatcct aggattatta 1012321 agcattacgg agggctcaat cagctggaag ggccgtcctg tgaattatca tatcagcaac 1012381 aaaatcggtt atttgccgga agagcggggc ctttatccga aaatgaaggt aagggatcag 1012441 ctcgtctatc ttgccagatt aaaagggatg gagaagcgag aggctgtaaa agagctcggg 1012501 acatggcttg aacgcttcaa tattacagat tacgagaata agaaggtgga agagctttcg 1012561 aaggggaatc agcagaaaat ccaattcatt tcggcagttt tgcataagcc ggagctcctg 1012621 attcttgatg aaccattcag cggcttggac cctgtcaatg ttgagctgct aaaagaggcc 1012681 gtgatctcgc tgaaaaacag cggtgtttct attttatttt caagccatcg gatggaacat 1012741 gtggaggagc tttgtgagaa cctttgcata ttgcagaaag gaaaaccggt tgtacaaggc 1012801 aagctgaagg agatcaagcg ttctttcggt aaaaagaatg ttaccattca ctccgatgac 1012861 gatctgcgct ttttgcagtc ccatgaaggc attcttcaat ggaaggaaac ggcagacggc 1012921 gtcaagctgc agattgccaa tgaagacatt tctcaagaga tttttgcgat gctccaagga 1012981 aaagggttta tcagaaagtt tgagcttgaa gagccgtcac tgcatgatat ttttatagaa 1013041 aaggtggggg ccgtctatga ataaattttg gatcatgctt tctcatacat acaaaaataa 1013101 gattatggca aaatccttta ttatttcgac tgtcatcacg gtgctgcttg ttttagttgt 1013161 aacgaatctg gagtcgatca tttctttgtt tcaaggtgac gatgcgaaag aaaaaatcgc 1013221 cgttgttgat gaaacaaacg aattatatcc ggttttttct aagcagctga aagcggtgga 1013281 tacagacggc gatcttgatg tgaagctgtc gaagcaatcg gaggatgagg tcacaaagca 1013341 agtcaaagat gaatcactcg atggcatgct catcatcaaa cgagatgaaa aagggaccat 1013401 ttcaggaaca tataaagcgt taacgatttc tgatgaaagc acgtatcaaa cactgcagca 1013461 ggcgctgacg caaaccaaaa cagctgtcgg aacagcggag ctcggcgtgt cgcaggaaac 1013521 gattagcagc ctttatgcgc ctgttactgt ggggcagaag gcgctgaaag aaggggcaaa 1013581 gtctgaggaa gagcttggcc agacggtagg gcttgtttac attatgctgt tcgtcattta 1013641 tttctcggtg attatgtatg ccagcatgat agcgatggag gtcgcaaccg aaaaatcttc 1013701 gcgagttatg gaaatcctga tctcaagtat gccgccgatc cagcaaatgt ttgcaaagct 1013761 gcttggtatc gggcttgtcg ggatcacaca gcttgctatt attataggag ccggctctct 1013821 gtcgcttaag ctgaaccaaa agagcgaaac ggcttcatct gtcggcggat tccttaattt 1013881 gaccgacgta tctgcaacca ctgtcatcta tgctgtcatt ttctttttgc tcggatactt 1013941 tttgtacgcg acacttgccg cgtttctcgg cagtgtcgtc agcagaatag aggacgtgca 1014001 gcaaacgatc acgccgatga cgcttttggt tgtcgccggt tttatgatcg cgatgttcgg 1014061 tttgaatgcg cctgacgcag gatttattac ggtaacttcg tttattccgt tctttacgcc 1014121 aatgattatg ttcctgcgcg tcggcatgct tgatattccg ttctggcagg cggctgtcgg 1014181 aatcggaatc acactgctca ccattgtcat actggccgtt atcggcgcca gaatttataa 1014241 aggcggtgta ttaatttacg gcaattcaag cgcgttcaaa gcgatcaaac aagcgctacg 1014301 tttagcgaaa aactgattgg aaaacagcct ggggattctc aggctgtttc tttattgaca 1014361 gaacgtgcat tcgcaagaat tcggtgctaa aataagggta cttcatcctg gaaaggagca 1014421 gaatgttgac tgatctaacc tttattcatg cggcagatct tcatcttgac agcccgtttt 1014481 acgggatatc gcatctgccg gagccgattt ttgcccggat taaagaaagc acgtttgcaa 1014541 gcgtgagaca tatgatagac gccgcagtga gagagcacgt tgatttcatt ttgcttgcgg 1014601 gagatctgtt tgatgaagcc aatcgaagct taaaggctca gctctttttg aaaaaacagt 1014661 ttgaaagact cagagagtgc ggaatttcgg tatacgtcat ctttgggaat cacgatcatc 1014721 ttggcgggga gtggacgccg attgaatggc ctgagaatgt ccatattttt tcgtccgctg 1014781 ttccagaaga aaaatcgttt tttaaagaag gcaggcgcat agcaagcatt tacggcttca 1014841 gctatcaagc cagagcattg atggaaaacc aagccgcccg ctatcggaga tcaactgacg 1014901 caccgtttca tatcggcatg ctccacggca cgctgtcagg atctgaagga cacgatccgt 1014961 attgcccgtt tacacatgac gacctcgtga aaagcgggat ggattattgg gcgcttggcc 1015021 atatacataa acgccaggtt ctatctgccg agcatccggc agtcatttac ccgggaaaca 1015081 cgcaagcacg ccatataaag gagacgggag ataaaggcta ttatctcgtt catgtgacaa 1015141 acggagatat atcttatgaa tttcagagag cgcatgatgt cctgtgggaa aaagcggcgg 1015201 ttgatgtgac ggaggcaaag aatatgacag ccctcttcca aatggtggag gacacgtttt 1015261 cgaagctgcg gaaaaagggg agccctgttt gtgtaaggct tgttttacaa gggacggcgc 1015321 cggaatggct gctggaggcg ccaaaaggca ccttggatga gtttcttgaa gctcttcagg 1015381 aacaagaagc ggaagaggaa cgtttcgttt ggcctcttag attggacgat gagacagaaa 1015441 acgaagcaaa cctaacaaac cttgatcctt tttttggcgg tttatttgaa gacattgatc 1015501 gcagcgatct gtcagacgtg ctggaagggc ttgagcggca tccagtgtat agaaggcacg 1015561 cggaccggtt tagccaagag gaggtaaagg aaataaaaga gcaggcacag ataatattga 1015621 aaagacagct taaggtgctt gatacatgag gcggtgacag ctttgcgaat tatatcttta 1015681 catatctacc aatacggaaa attttccaat cggacctttg acttttccgc ctctcctgtc 1015741 caagtcatct acggattaaa tgaggcagga aaaacgacga tgatgtcatt cattgaaagc 1015801 atgctgttcg gttttccgaa aacgaaaaag tatgaaccga aaacaggcgg tgtctacggc 1015861 ggtgttcttg aagctgaaca tcctgagtat ggggtgctga agatcgaacg gacgaaaggg 1015921 actgccgaaa aactaagcgt gtacacagaa aagggcgaag taaagcaggg agatgtttta 1015981 aagcagctgt tccagggcac agacaggtcg ttgtacaaag ccatatattc gttcgacgta 1016041 ttcgggctgc aggaaattca cgcctttaat cgggacaaga taggggaatt tttgctcttt 1016101 tccagcttgt ttggtgctga agccgtatca aagcttgatt caaggctgac gaaggaaagc 1016161 gaaaggctct ataaaccaaa tgggcgaaac cctcaattga atcaggagct ggaaacgctt 1016221 aagcagctgg cagttaagct aaaacaggct gaagcagagg aagcgggcta tcatcagctt 1016281 ctcgaggaaa aacgaacgct tgaagcccgc cttgcagccg cggaaaccga attgaaagag 1016341 acggcgggac atatccgaat gattgaggga gcgattgagc gaaagccgct gctaaatgaa 1016401 aaagcgacac tcgaacaggt gattgcagaa tttccggaac acgcaggaca atttcctgct 1016461 gacggactgc atcagctgga aaaatatgaa tcccatcttc acccgaaatc agcacagctt 1016521 gaggcgcttc gggtgaagat ggcggagttg gacaaacaga ggcaaaagct tatccccgat 1016581 aaagaactat tggcgaaaga aacgctgata caagagcttt cggcagcgtt tcatatgtac 1016641 caatcctggg gagaacagct ggcagccatt caggcacagc tgcgccagac gtctgcgcag 1016701 acagcggcag ggctggaaca gctcaataaa acggatgaaa atgagctcct gaatatgaac 1016761 acctcatatg attatgaatg gcagcttcag caagcggtgc agcaatatgt acaggcaaga 1016821 gacagaaaac ggcagcttga cgagacgttt gaacttgccc ggcaagagct ggaagacgcg 1016881 gaaaaggccg ttcgtgccgc ttcgtccgcg attcttgaaa acagccaaag aaaagataaa 1016941 gaagcagctc ttagagcata tgatgaaaca caggggcagc accaagagca agcgaagctc 1017001 agagaacagc taacgttttt tgaaagacag caggctaaac agaaaaagac tgtcattgca 1017061 gctggtatgt tgttcatcgt tctcttttct ctgctgcagc aatggattcc cgccataagt 1017121 ttcggcgctg cacttattgt gtattggctt gtttcaggaa agtcgtcttc tcgaaacagc 1017181 cgagagacaa gacagcccat gacggatatt tcaccagcag aagctgaaat gcttagagaa 1017241 gcgttatggg aggatgaccg caataagcag caccttctca cacagcgtgc agcgctccag 1017301 caaaaagagg cggcgtatga aagggtcatc cagcagtttg aacagtggga agccgaaatg 1017361 gcgccgtcct ttacacaggt tgagcgtttt atgaatgagc tcggatttaa ggaagatcca 1017421 tcatttttgc ttgatgcata cagcttaatg aaggatgtta aaaaagaagt gaagaaaaag 1017481 catgagctga ccatagaagc aggcaggctg aaaaagcacc ggagaacatt cgaagaacgc 1017541 gtcagtatgc ttcttcccgt gaatcagagt caggatatct ccatttcgga cgcccttcac 1017601 acattgcgga aaaacattga acgtgaaaaa gaaattgaga agcaaaaaaa ggaaattgaa 1017661 acagatattc attatacaaa ggaacagatg cttgaacttg agcaagaaat acagtatttc 1017721 cacgcacaga ttgaacagtt atttgccgcg gctgctgcaa aagacagaga tgcgtttttt 1017781 gccatagccg ccatcagcag gcaattgaag gatacggaga acaagcttca tcacgtaaac 1017841 gcacagcttc aaggcgggta cccggaggaa cttgaactgg cggattccaa tacgctttct 1017901 gaattgaaag ataagcaatt tgttgagaat gaaagaaaag agcggctgac tgaggagatc 1017961 gagcagctcc gcagccaaat cgcactgctc tcagtcaaac aggaacaatt agaggcttcg 1018021 ggaatggtct cagacctcaa gcttcaaacc gaaatgcaaa aagaacgtgt gaaagaaacg 1018081 gctaaaaaat gggcctccat acaaatggtc aaacaggtga tcagaaacaa attggagcgg 1018141 cataaaaaaa tcgagcttcc gcgccttctg gagacggcag gagaattttt ccgtcctctg 1018201 actgacggaa actaccaaac catttatttt tccgaaacgg atgattcgat catggttatg 1018261 catcgcgatg gcactgtcta tcatgcggaa gagctgtcac aagggacgtg tgaacagctg 1018321 tatacagcga tccgctttgc tttggccgtt acgcgccagg gtgagtcaaa gcttccgttc 1018381 cagcttgacg acagttttgt tcattttgat caggaaaggc tgaaacgtgt attacatgtt 1018441 ctgtatgatt tatctgaagg cggtaggcag attttgtatt ttacatgcca tgagcacgta 1018501 aaagatgcat ttcatagcag ccaaatcatc catttggtgt cataaaagag gttctatagc 1018561 tgaaaatcgg tatgtgatat actggtatta tgtaagatac ggagggagct ttaatagaat 1018621 ggctaaaggg attatgctac atgaggttgg cgaacaggtg gaccagtatc tattgattaa 1018681 atcctcgacg aaagggattg caagcaatgg aaaaccgttt ctgacgctga tgctgcaaga 1018741 ccagtcaggc gatattgaag cgaagctgtg ggatgccaag caaagtgatg aagtgaccta 1018801 tgcgccgcag acgattgtca aggtcgtcgg cgatgttcac cattatcgcg gacgcaccca 1018861 gctgaagcta agaaatatca gaccggtaag cgagcaagaa aacgtcaata ttgatgattt 1018921 tttagaaacc gcgccgattc cgaaaaatga aatgatggat accatcactc aatatatatt 1018981 tgaaatgaaa aatccgaata tccagcgaat cacaaggttt ttggttaaaa aacacgaagc 1019041 tgagtttatg gattatccgg cggctacgaa aaaccaccat gagtttgtct caggtttggc 1019101 gtatcatgtt gtctctatgc tgaacctggc gaaagcaata gcagatttat atccttctct 1019161 tgatcgtgat ctgctttacg ccggtgttat cctgcatgat cttggaaaag tgaaggagct 1019221 gtccggccct gtttccactt catatacggt tgaaggcaat ttgctcggcc atatttccat 1019281 catggtgaca gagctttcaa aagcggctga ggagcttcaa atcgattctg aagaggtgtt 1019341 aattcttcag catttgattt tgagtcacca cggcaaagca gaatggggca gcccgaaacc 1019401 gcctatggtg aaagaagcgg aaattcttca ctatatagac aatctggatg caaaaatgaa 1019461 tatgatggac agagcgcttg agcgcgtgaa gccgggcgag tatactgaac gtgtatttgc 1019521 actggaaaac cgttcctttt ataaaccgac atttcataaa taacttaaaa aggactgatg 1019581 ctgacatatt cagctcagtc ctttttgatg cgtctttccc gcacataact cgtctcattc 1019641 ccgcatatgg ttaagaataa agaatctatg caaaggggga ggagcccgtg ttattttttc 1019701 cgtggtgggt gtatctttgt attgtaggca tcattttcag cgcatataaa cttgtggcgg 1019761 cagccaaaga ggaagaaaaa gtagaccagg cttttattga aaaagaagga cagatttata 1019821 tggagaggat ggaaaaggag cgagaacgcc gcagttctca gcagcatgaa gaagaaaatc 1019881 aaaaccattc catcgcataa aaaaagctgt gcggctcaat gagccgcaca gcttttttta 1019941 ttatttagaa ttgcttgaag atgaagaagt gctgttgctt gttgaagatg tattaaatgt 1020001 gtctttcaga tctttatctt ttacttcgat gtcagccttc ttcatgactt tttgaacagc 1020061 ttcctgaaca gctgcgttgt catttaattt ttgttcaagc acttcagatt tcagttcttt 1020121 tttcatatca tcatatttgc cgcgttcttc tgtcttttta atgatatggt agccgtattg 1020181 cgttttgaca ggatcactga cttcacctgt ttttaatttg aatgcagctt tgctgaatgt 1020241 ttcgtccatt tggccttctt ttgcgaacca gccaagatcc ccgccttttg aagcagagct 1020301 gtctgttgag tattctttcg caaggtcttc aaacttctcg ccttttttca gctttttctc 1020361 tacttcttca gctgtctttt tatcagcaac aaggatgtgg cttgcacgga ttttgccttt 1020421 taagccttcc cagtactctt tgatatcggc gtctgttact ttgatgttat ctttagccgc 1020481 tttttgtgtc agcaattcat attttacttg ttctttcagg taatctttgc catattgctt 1020541 ttcgagggca gtatattgat cgccaagctg cgttttgtat tctttcagct tgttgtcaat 1020601 ttctttatcc gaaactttat acttcttgtc caatactttt tcttgcacta gctgtgtcag 1020661 tacgcttgcg ccagctgttt tcttcatgtt tgtgtaaagc tcgccttttg tgacatcgcc 1020721 tgcgtctgtt tttgcgataa cttctttgtc gccgctgctg caagcactga gagcgaggat 1020781 gcttgtagca gtgatagctg ctattgcgat tttcttcatt gttttcaaac actcctaatc 1020841 attccaaatt aaattaccta tgcgtatcat aacatattgt ggctttctgt aaaaagattt 1020901 taaataaagg gcattcgtct agtcaaactt ttgctgatga catacttata tattgatcaa 1020961 gaaaaggagg tatgtaacat gagcggagga tactctaacg gattcgcgtt gctcgtagta 1021021 ctgttcattt tgcttatcat cgtaggtgca gcttacatct actaagcagc ccgaggatcg 1021081 cttgcaacat aagcgatcct ttattttcac tagcgcctaa tcgtttcaaa catgaattgc 1021141 ataacatgta attggtaaat aaagcttatt acaggaggtg ctatttaaga tgggtgaagt 1021201 atttgcaggc ggattcgctt tattggttgt gttatttatt ttattgatta tcatcggcgc 1021261 ttcttggctg tactaatcaa cataaaaaag catagctgct taatcagcag ctatgctttc 1021321 tttcgtattt acactgtaaa ggagatctcc acaaacgaag agatcagtaa aattaatata 1021381 gatacattaa taaatcggaa taccttatct tgccgctctt caggaatctc tctgacaagg 1021441 cataatgtat tggtgagcct gtttatgaaa tataaaataa acacggcagc cacgataaaa 1021501 tagaataaaa tgatgggaga ttccccctct ctctgaactg tcccatatta cattaccaaa 1021561 tatttattaa aaaagataga atgcaaattg aaaaatcgcc accagcacca gggtttgact 1021621 acttttcaac aagaatatcc aagccgtcag cttcctgatc aataaaagcg gttttcggtg 1021681 cttttatcag cttgagagcc agcaggaaat caggcagaca gtagccggcg tgaatgcccg 1021741 agatcatgca aaaataatga gcgtgattcg gaaatgccag tgctgcgtaa aacaataccg 1021801 gtgtaatcag caagaacggg ctgacgagtg aaatcagcat tgttgttttt ggtatacgtt 1021861 tccatgtgcg catgcgcaat atgtaaaact ttttttctat ttttcttttt ttgcagatga 1021921 ttggcaggac atggatgact ttatgtacaa ataaaataac gacgagcaaa ccgccgaata 1021981 aagatacata ttcatcgctt aagcttgtgc caggccgcag cagctcaaaa gctaaaaagg 1022041 tagatataaa aaccaaaatc ataaaacata cagcagttaa tattatgcga acggcgccat 1022101 aatccttcat gagatttatg gtcttccagc aattcatcaa agtcatcctt ccatacatct 1022161 tgaatagaat ctcaaaataa tttactcctc ccaagagaaa aaatcaatgc ttttttaaga 1022221 aaaaatatca tccggcaggt atttttttga aacaagcaaa caaactgcga aatatggggt 1022281 tagaactttc ttctcagtga attatcagct aaaataagat taaagataga aagaagtggt 1022341 gtggatggat tcgatggatc atcgcattga gcgattagaa tattacatac aattattagt 1022401 gaaaacagta gatatggaca ggtacccctt ctatgcgctt ctcattgata aagggctgag 1022461 caaggaagaa ggggaagcgg ttatgaggat atgcgacgaa ttgtcggaag agctggcaac 1022521 acaaaaagcg caaggatttg taacctttga taagctcctt gcgctttttg ccggacagct 1022581 gaatgaaaaa ttagatgttc atgaaacaat ttttgccctg tatgagcagg ggctttatca 1022641 agagctgatg gaagtcttta tcgacatcat gaagcatttt gattaactgt ttacaggttc 1022701 gagctcttca gccggttcat ccgccgcact gtcctttgct tttttcttca attttccgtt 1022761 tacgctttca aagtcattgt caatattggt gagtgacgtt tcgaaaattt ccataaaatc 1022821 atcgccgtag atatggcgta tcatacacat catttctgcc acttcaggaa attttccgaa 1022881 taaatgatat aaaggctgtg accctttaaa aacagcgttg cgtgtcggat caaattcctc 1022941 aagcaagctc cagaatacct cggtaccttc ctcagtcaat tggacatatg tgttccgttt 1023001 atcattcagc cgtttggaga accttaaata tccccgttct tccagctttt ttgaaaagtt 1023061 gaatgcggtt gatacgtgca tgaccccgaa tttcgcgatt tcagaaatgg aagctccatt 1023121 caattgatac gcaatccata aaatatgatg ctcattaata ttcaggtcat acggtttgag 1023181 ccattgctgc caatccttct cgatcgattt ccaaagagcc ttgctaagct gagccatttt 1023241 ctgggtgaaa accagagctt ctttcacatc atagggcggt tccactcgat tcattacgtc 1023301 acctgcttct ctttttcttt ttctctatta tgccaataaa ataaagatta ataaagatga 1023361 aaatgtaaga attttttaat aaattcacaa accattgcga cgaaagggtt tttcggccaa 1023421 aaaaaatacg ggtccaattt tggcccgcat ttttttcttt tgaataggat attagttttg 1023481 taaggttttc tccagctgtc tgattttctc ttcgatatcg gcaatttctt tttgcagatc 1023541 ctgctggtga ggcttgatct cttcctgcca ttttttaatt gatgtttgga gctcgccgcc 1023601 cacgtcttta ataacatccg tgctttcttt tgccgctttg atcagctggt cttttaatgc 1023661 aagcccgtct gactttaagc gtttgattgt ttcttcaaaa gaatcataat tggttttcat 1023721 tttttcacgc agctgctttc ctgaggaagg tgcagtaaga agaaccgctg ctcctccgat 1023781 gatgccgcct acgaatagtc ctgttaatag agaacgtccg ctcgccatta caatcacccc 1023841 gtctttttct tcaaaatagg attcattcag catttttcat ttttgttgaa agcctgaact 1023901 tctatacata gcttgcttta ttttagcata ttttttaagt gaaaaggagg gagaaggttg 1023961 tctgtctttt tgattgtatt atcctgcatc acccttgcct tcgcttcagg cgctgtttac 1024021 tatatcaaac ttctcagcca ggctgcttct tatccgccca agagggttat ccggcagaaa 1024081 gcgcttgttt gttcaaccgg aaccgccttt acactatgtc ttatcttttt cacaaaactc 1024141 ctcgcttaaa acatgctgac atgctgcggg cgctctgttc aaaaaaacct ctcccggaag 1024201 cggaagaggt tttgtgtgac aattatttag cagcttccat aaagcttgaa cgccttaaaa 1024261 tggtttgcac aatcggataa ataatgatca ttgagattgt attcagcaca gcggccggca 1024321 gaacaacagc cgcgaacaat gcggcgaaac cgcccggtaa accgacgatc aataaagctg 1024381 acgatagaaa cacaattcct gataagatgg tcccgatcac tgtcagcaca gcggctgcac 1024441 ctgttttccg gctctttctg aacaagagaa acagggagaa gaacagaaac gctgatacgg 1024501 gtttatcaat gatgttaggg atctgtccgg ctggaaacgc ggttgtaagc gcggaaatga 1024561 ttccggtcac gatcccgatg acgagtacat tttgcacccg cgggaacagc agaatgccca 1024621 tgaacatcat gatcagcatc atatctggtt tcatgccgcc taaaaagggc ggaataatgg 1024681 aatgaagcgc tgcgccgatt gcggcaaaca gagccataat gactaactct tttgttttca 1024741 taactatgct ctcctctgct aagctttttg ccctccaata atatgctcat catttattgc 1024801 gaaggcttta cagaatgtgt tatgcaaaca gtataccaaa cggacggttt gcatagccag 1024861 actttttact cattttcctg ctggaatttc ttcatgaacg cagctaattt ttcacagtct 1024921 tcgagagaga ccgcgttata aatagaagcg cggcagcctc ccaccgaacg gtgtccgcca 1024981 aggccgatca tcttcgcatc ttttgctttc tgaacgaatg ttttcgttaa ttcgtcatcc 1025041 cgaagcgtga atgtgacatt catgcgtgag cggctgtctt ttctggcatg tcctttatag 1025101 aagccgttgc tttcatcaat acagctgtag agaacctgcg ctttttgttc attgcgctgt 1025161 tcaacagctt ccacaccgcc gttttccttg agccattcca gaacgaggct cagcatataa 1025221 atcgcaaatg tcggcggagt gttgtagagt gaatccgctt tgacatgcgt ggaatatttc 1025281 aagatttttg ggacgttcgc attttcattt tgcagccagc tttttttcat gatgactaca 1025341 gtcacgccgg aagggccgag gttcttttgg gcgcctccgt agatcacatc aaatttggac 1025401 acatcgattt ttctgcttaa aatatcgctg gacatgtcgg ctacgagcgg aattggagaa 1025461 ttcggaaact cctgccactg agtgccgaaa attgtattgt tggatgtgat atgtaaatat 1025521 gcgccgtctt ttacatccgt aaggtcaacc tctggaatat aactgtaatt gtctgtttca 1025581 cttgtagcgg tgatagacgt gttcccgaac agtttcgttt ctgccagtgc tttttcagac 1025641 caagcgccgg tcatcacaaa atgtgcggtt ttttcaggtg ttaaaaagtt catcggaagc 1025701 attgagaatt gaaggcttgc cccgccttga agaaacaaga tatcgtaatc ttccggaatg 1025761 cccatcagtt cgattaagag gcttttcgct ttttggtgca ccgcttcata ctctttgctg 1025821 cggtgggaaa gctccataac agacatgccg gattcgttaa aatcaataaa ttctttctgt 1025881 gctttttgca gaacttccag tggcagcgct gcaggacctg cgttaaaatt cgttgtacgt 1025941 tccattatga tctctccctg ttttccacgt taatgtataa aataatacaa ttatcctatc 1026001 acaaaaattc agttttttga taaaaaatta gaattatcaa aagaaattga cggatgtttg 1026061 cgaaatgttc acaaaataaa ataacctcat cttatgatga ggccaggcgt tttgcgatag 1026121 aggaagagat gttctgcaga tcctccggtt tataatcatc agcatgcgtt ttccaaaccg 1026181 ctccgaatcc atctcctttt ccgtagcgag ggataatatg catatggtag tggaacacag 1026241 attgtccagc tttttcgccg ttattgttca gcgtatttaa gccgatcggt tcaaattcat 1026301 cccggatagc gcgggcgatt tttggaacag catggaaata ttgttttgct aattcatctg 1026361 taaattcata tacattctca atatgtgttt tcggaatgac aagcgtatgg ccttttgtca 1026421 cttggctgat atcaagaaag gcaagtacat gttcatcttc atacaccttc gctgatggaa 1026481 tgtcgccggc aataatttta caaaagatac aattctctgc acaatgcatg agggttcctc 1026541 cttatgaaat tgtttagtat gtatacattc atcgtaccac agaaatgcag aaaatagaaa 1026601 acaggatgaa cggcgagcgt tcaccctgaa tgcagaggaa gagcttatat gaagaaaatg 1026661 tgttatgcct ttggtaagca cctcatttgt caataaaatg aagacttgtt taatgcctaa 1026721 cgattcctgc gataaacacc tcatttgaca atttgcttca tacatgaaga attcatcaat 1026781 tcagtgaaga gaaatggttt gagcattgga catgtttatt ttctatccaa ctgtttctaa 1026841 gacgtctttg acaaacacct catttttcag ttgatatgct tttcctctac aacttttatg 1026901 atgtccagaa ccctgtctct ttatgacagc aaattcatca tttgttaaaa gggaattgtt 1026961 tcaaatcagg ccttgttttt ggtactatga agaaaaacac tataagggga gaaactatgt 1027021 ctctgctatc ggtaaaagac ttgaccggcg gatatacaag gaatccggtt ttaaaaaacg 1027081 tatcattcac ccttgaaccg aatcaaattg tcggcttaat cgggctgaat ggtgctggta 1027141 aaagtacaac aatcagacac atcatcgggc tgatggaccc gcataaaggt tcaatcgaat 1027201 taaacggtaa aacgtttgct gaggatccgg aaggctaccg ttcacaattt acctatatac 1027261 ctgaaacacc tgttttatac gaagaattga cgctgatgga gcatcttgaa ctaacagcca 1027321 tggcatatgg actgtcaaaa gaaacgatgg agaaaaggct gcctccgcta ctaaaggaat 1027381 tccgaatgga aaagaggctg aagtggttcc cggcccattt ttctaaagga atgaagcaga 1027441 aggttatgat tatgtgcgca tttttggcag agcctgcgct ctacattatt gatgagcctt 1027501 ttctagggct tgatccgctt gccattaacg cgctgcttga acggatgaat gaagcgaaaa 1027561 aaggcggggc gagcgtgctg atgtcaacac acattttggc aacggcagaa cgctattgcg 1027621 attcgtttat tattttacat aacggcgagg tgcgggcgcg cggcacgctg tcagagctca 1027681 gagagcagtt tggaatgaag gacgcggcgc tggacgattt gtatcttgag cttacaaagg 1027741 aagacgctgg ccatgaataa tatgcttgat atttggcagt cgcggctgca ggagcatatc 1027801 aaagaaacaa gaacatacat gaaatatatg ctcaacgatc acctcgtcat tgttttgatt 1027861 ttttttctag cgggcgctgc aagctggtac agcaaatgga tacgggacat tcccgctcac 1027921 tttccgtcct tttgggtgat ggccgtgctg ttttcgctcg tattgacaag ctcttatgtg 1027981 cgaacgcttt tgaaggaggc tgaccttgtt ttcttattgc ctcttgaagc aaaaatggag 1028041 ccttacttga agcaggcgtt tgtctacagc tatgtgtctc agctgtttcc gctgattgcg 1028101 ctgagcatcg ttgcgatgcc gctttatttc gcagtcactc cgggagcttc gctcgtatcg 1028161 tatgccgcgg tctttgtcca actgttgctg ctgaaagcgt ggaatcaggt aatggaatgg 1028221 cgaacgactt tccaaaacga ccgcagcatg aaacggatgg acgtcatcat tcgctttgcg 1028281 gcgaatacac tcgttcttta ttttgttttc caatctgttt atatgtatgc gcttctcgtc 1028341 tatgtcatta tggctgttct ttatctgtat atgtcttccg cagcaaaacg gaaaacattt 1028401 aaatgggaga gccatattga gtccgaattg agacgaaagc agcgtttcta tcggattgcc 1028461 aacctgttta ctgatgtgcc gcatttgcga aagcaagcca aacgcagagc ttatctcgac 1028521 tttttgctgc ggcttgtgcc gtttgaacag cgcaaaacat ttgcctatat gttcacccgc 1028581 gcctttttgc gttcgagcga ttatttgggc attcttgtca gattaacgat cgttttcgcg 1028641 ctgatcatta tgtatgtctc agccagcccg ctgattgccg cggttttgac tgtgtttgcc 1028701 attttcatta cgggcattca gcttctgccg ctcttcggtc actttgacca tctggcgctt 1028761 caagagctgt accctgtgca aaaagaaaca aagctgaaaa gctatttctc tctattaaaa 1028821 actgcactta gtattcaagc gctgctgatg tctgttgcat ctgcctatgc agccggcttg 1028881 accggttttc tgtacgcgct gatcggttct gccgttctga tttttgttgt tttgcctgct 1028941 tatatgacga ccaggctgaa aaagcacgga aagctgtgaa ctgaaaagag gtaatcaaat 1029001 gacagataat cagctgctga tgcaggaagc tttggaatgg aaaatgcatt ttttgcgaaa 1029061 ggattccatg tttgaacgct tttcgaagcg tgtccagacg aaggtgaatg aacggattcc 1029121 tgaaaaaatc catacggtcg tcaccgagag tgtgaaaaaa atggtagaag cgacaatggc 1029181 cggctctaat atcatcacct ataaaaagga tacaagtgca ctgtcgctca gtgaaaaaaa 1029241 cgaattggcg aaaaaaacga ttgtttctta tcaaaaagtg gcagctgctg agggagtcgg 1029301 caccggagcg ggcggcattt ttttaagcat tgctgatttt ccgctgctgc tttcaattaa 1029361 gatgaagtgt ttatttacct tgtcttccat ttacggcttt gatgtcaagg atgcacaaga 1029421 aaggatattt ttgctgctcg tgtttcagct tgcgttttcg agtgatgatg gccgtaagtc 1029481 gcttttttct gtcatcgaaa attgggagac ggagaaaaag agcatcgact ggagagtgtt 1029541 ccagcaggaa tatcgcgatt atatcgacgt cgtgaagctt tttcagcttt tgccgggcgt 1029601 aggagcggca gtcggcggaa ttgccaatta taagctgctt gctcagcttg gagaaacggc 1029661 aagacatgtt tttcatctga ggatattaaa ggaaacagcc ggagaataaa cactccggct 1029721 gtttttttat agctgatgat aggtgatcgc agcgccggca aggaccttgg ccgctgtcag 1029781 catggctttt tcgttgatat caaatttcgg atggtggtgg gaatagactc gctctggctg 1029841 ttcgggagcg gcgcctgtaa agaaaaaagt gcccttcacg ttttgtaagt aataagcaaa 1029901 atcctcgccg cccatttgtg gttcaccgtc aatgacctgc tgaacgccct cggtattctt 1029961 tgcggtgctc accaagtggt tcgtttctgc aggatggttc acaaccgctg gataaccctg 1030021 ttcataggtg tactcatagg acgcgccgtg catgctgcat attcctttta caaccgcttc 1030081 aatttctttc tccagaatgt cccggacatt ttcatcaaaa gaacgcgctg tgccgatgag 1030141 tactgcttgg tctgcgatga cattaaacgg attgtcggcg atgaaggagc ctgtcgaaat 1030201 gacggcggat tgaatcggat tgactttgcg gctgacaatg tgctgcaaag aggaaacgat 1030261 ttgcgaaccg attaggacgg cgtctttagt atcatgcgga tgagcgccgt ggccgccctt 1030321 tccgaagact ttaatcgtaa atcggtctgc cgccgccatt acggcgccgg ggcggcagag 1030381 aatagttccg agcggctcag ttgcccaaag atgagtgccg aatatcacat ccgtgttttc 1030441 gagacatccg tcatcaatca ttggctttgc gcctccagga taatattctt ctgcatgctg 1030501 gtggatcatc acaaatgttc ccttcagttc atgtctgttt tggtgaagga ccttggccac 1030561 tgcgagaaga gctgcggtgt ggccgtcgtg gccgcatgca tgcatgacac caggcacttt 1030621 ggaggcgtaa gggacatctt tttcatcttg aatggggaga gcgtcaaagt cggccctcaa 1030681 agcgactgta gggccgggtt cgcttccttc tatatttgct aaaacccctc taccgccaac 1030741 gtttgtgcgg attgggactc ctaacgattc ataataggaa gcaataaatg cggcggtttt 1030801 ttcttcttga aatgagagct caggatacat atgaaaatgg cgcctgatct caaccatttc 1030861 ttcaaaacag ccgtcgagct gtttgtttat ctctttctgc agtgtggata tggacaaagc 1030921 cgcttccccc ttttctatgc ttttccatga ttgtatagaa aaagtctgaa tatttcaact 1030981 catgctgttt taaagcatca tcacagctgc gagggttgtc accaaaaggc caatcgcgac 1031041 gggaatgaag ttttttctgg caagctcaaa aggatcaact ttgcaaatgg ccgcggcggg 1031101 aatcaaagcc catgggacca gtgttcctcc gcccacccag atggcagaga tttgtccgag 1031161 cgcggtcaga atagcgggat cggcatggag agcggacgaa aagagctttg cgatggagcc 1031221 ggcgagagaa atgccagaaa atcctgagcc gtcaaggcct gttatggctc cagcggcagt 1031281 taatgcagtg gcggcaagct cctttgacat aggcatcata tgggataaag caatgccaag 1031341 atcgttgaca atgccgtggg aacctttagg gagtgaagtg cccagtatgc tttcatagcc 1031401 tgagtcgcca agataaaaga aagcggcaat cgggatgacg gggccgaaaa ccttaaaacc 1031461 gaacttaaat ccgtcaataa aatagccggt gattttttca agccctttat gcttatacac 1031521 gaaaaaatga acggtaaaga ggatacaaat tgcagacccg ccaattaacg cggttgcatc 1031581 atttccttgt aggttaaaca agagcatgca ggcgatatct gcaagaaagg caagcggaat 1031641 caaaaaagcc agtatggacc gcaggcgttt tggcaagtac agcgagttgt cttgttcgcc 1031701 ggaaagaacg ggggaaaaag aagtgggatg ctcctgtttt ttgcgttcgc gctgaatcat 1031761 gataaaggca gcagttgttg ttgtcacacc cataatcagc acaagcggaa tactggccga 1031821 gacgacatca ccgactggaa tgcctgctgc atccgcagtc agctttggcg ccgcctgaat 1031881 gacaaagtct cctgacaggg caaaaccgtg tccgaataag ttcatggcca tggccgcggc 1031941 aagaggcgtc aaaccggcac gtgcggctgc ggggagcagg acggcgccga tcaaagcgac 1032001 acccggagaa ggccagaaga atagagaaat ggcgaacatc aggcctccaa tcagccaata 1032061 ggcagtcaca ggccctctca caaggcttgc aaagggagaa atcatcgctt catttatccc 1032121 tgtttttgtt aacaaatcac tcattgaaac gataaagcaa atgatgaaaa tcgtgggcag 1032181 cagttcgccg gccgcataga taaagctgtg gaataaactg ctgacagaag ctgaaagtga 1032241 atggctggcc catagcgata tgataaaaat gccgaataga gaaataaatg tcgtgtcttt 1032301 tctcagcagc ataaatagga taattgcacc gataaaaaac acatacagaa catggacagg 1032361 caaaatcccg acttccatca tcgatcactc cttccgctta cagattattc ataggcgggc 1032421 ggaaggtgcc gggacagagg ggagggttat gatggaagat gaacattgat ctgtttcagc 1032481 tgctcaatca gatgatgcct taatcctcta ttcgcttttt gcagatgttt tgggaagcat 1032541 tcaggagaaa aaatgacgca cccttcagca agccagtttt ttctataggc gatgatgctt 1032601 tccgatggct ctatatgagt tatcctcgtg ctgcatctcg tactcatcaa atccgaactg 1032661 aaaaccgcag cacgggcaga tttcatgaga atgattgcct tcatgatcat atggcggttc 1032721 agccaatcct taaacccgca gactgggcaa gtatgcttca ttttgctttc ctcccaataa 1032781 aataagctgc cggacatgcc ggcagctatt cgacagcgaa atatgtggtg acataggaag 1032841 gccgggagaa gatcgacgtt gtgtcaattc cggcagatgt atcgcgtttt ttgtgggctt 1032901 ctttgtaaga accggactgc tgccagtctt gaaaggcgct ttccgtttcc cacaaggtca 1032961 gaatgacata ggtgtcactg tcaagcggac ggagcactcg aattgcttca aagccaggct 1033021 cgttttcgac ttttcccgct ctgtttttaa atctgttttc aaacagcgga cgcccttcct 1033081 gagtaacggc aatattgttc aatactgcaa aaccgggatg tttgatctct ccgacttggt 1033141 caatgacttc ataagcgtgt ggtgcctgga aaacggtatc tccgtttgtt tcatgaatta 1033201 aaatggcgtt ttcctgcccc tgcatcaaaa ggatattttc tgagggatgc ttctgtacga 1033261 tcgtttttaa aaaatcggct gtcccatatg taatataaac cttcatatca gccacctcct 1033321 gcttgctagt atatcaaaac aatggtataa gtttctattg gcgagtgctt cgaacataat 1033381 tccaaacaat ttttcccata ctacctttag aaaggcgagg tgagttcatg tttaagataa 1033441 agaaaaagaa actttttata cctatcatta ttttagtgtt aactgctttt ctcgctttaa 1033501 taggatatat ttcaattatt tttctcggcc attatgtcat agatgaaaaa aagcttattc 1033561 ttcatgcttc ttcaaaaatt gttgatcaaa acggagatga ggttgcaagc ctgtatacag 1033621 aaaatcgcga gccggtctcg atcaatgaga ttcctaagca ggtcagagaa gcgtttatcg 1033681 ctgttgagga taaaaggttc tatgagcatc acggcattga tgcaaaatcc gtcggaaggg 1033741 cagtgtaccg cgatatatta gcaggcggaa aggtggaagg cggaagcacg atcacccagc 1033801 agcttgccaa aaatattttt ctgacacatg acaaaacatt tctaagaaaa acaaaagaag 1033861 tgatcattgc gattaatctt gaacgggatt acagcaagga caagctgctt gaaatgtatt 1033921 taaaccagct ttacttcgga cacggggttt acggcataca agcggcgtcc cactattatt 1033981 ttaataaaga agtaaaagat ttgactgtat ctgaaggcgc tgttttggcc gctattccga 1034041 aggcgccttc tacgtactct ccaattttgc accctgataa aaataaggag cggcgtgata 1034101 caattctagg tatgatgaat gaccaaggct atatcagtgc gaaagaggct gtcaccgcac 1034161 agggccggac gcttggactg catgtgaaga aacagtcgga aacaccttgg tttgacagct 1034221 acattgacct tgtgatcaaa gaggcggaag acaagtattc catttccgga gagcagcttc 1034281 ttcaaggcgg atacacgatc aaggtgccgc tcgattcgaa gctgcagaag acggcttacc 1034341 aggtgatgaa agagggaagc tattatcccg gaacagatca gaatgccgag ggaagcgcgg 1034401 tctttattaa taacaagaca ggcggtgtag aagcggccat cggcggaagg gattacacat 1034461 ccaaaggata taaccgtgtc acagctgtcc gccagccggg ttccacattt aagccgcttg 1034521 ctgtatacgg accggcgatg caggaaaaga aatttaagcc atattctcta ttgaaggatg 1034581 agttgcagtc ctacggagat tatacgccga aaaactacga cagccggtat gagggcgaag 1034641 tcactatgtc tgacgccatt acgtacagca aaaacgcgcc ggctgtctgg acgctgaatg 1034701 agatcggcgt cgaaacaggg aaatcttatt tgaaagcaaa cggcattgat atccctgatg 1034761 aaggccttgc tcttgctcta ggcggcttgg aaaaaggcgt ttcaccgctc cagcttgccg 1034821 gcgcgtttca tacatttgcc gcgaatggaa cgtatactga acccttcttt atctcgagca 1034881 taatagatga agacggagaa acaatagccg atcataaaga agaaggaaag cgggtattca 1034941 gcaagcagac gtcttggaat atgacgagaa tgctgcagca ggtagtcaaa aagggaacgg 1035001 ccacgtccgg cacctatcac ggcgacctgg cgggaaaaac aggttcaaca tcttatacag 1035061 gcgtctccgg cgcgacaaag gacgcctggt ttgcaggcta tacgccgaaa ataaccgggg 1035121 cagtctggat gggctatgac aaaacggatc aaaaccatta tttgaaagcc gggagctcat 1035181 acccgacgcg gctgtttaag gatattttga cacaggcagg agaaaccggt catgtgttca 1035241 caaagcctaa aaacgttaaa gaactggaaa gcccgattga gctgaagccg gtcaaaacac 1035301 tcacagccga ttacacattt aaagcagcgg ggctctttac tattgaatta aagtgggacg 1035361 ctcaagagga tgatcgggcc gtatacagaa tttatgtaaa caaggacggc gaggagacgc 1035421 ttcttgattc ggttgaaggg aagggaagct atgaaattcc ttatgccaac ttattttcgg 1035481 gcgcgtctta taaaattgtg ccttataata cacagacaaa aagagaaggg gaaggaaccg 1035541 attacgttca gccaaaattg ttttcctctt aatggaattc ggcgattttt tgaactttga 1035601 gctacatttc tataccattt gcctaaaaca aggtatagtg taataagtca agaaatacga 1035661 acgtatggtt gccgtatgaa aggtggaaat cagatgagta aacgagaaac gtttaacgag 1035721 acgtttttaa aagctgcgcg gggagaaaaa gcggatcaca cgcctgtgtg gtatatgagg 1035781 caagcagggc gctcacagcc ggaataccgc aagctgaagg aaaagtacgg attgtttgag 1035841 atcacacatc agcccgaact ttgtgcgtat gtcacaagac tgccggttga gcaatacgga 1035901 gtcgatgctg caatccttta taaagatatc atgacgccgc tgccgtcaat cggtgtggat 1035961 gttgaaatca aaaacgggat cggtcctgtg attgatcagc caatccggtc tctggcggac 1036021 attgaaaaac tcggccagat tgatccggaa caggacgtgc cgtacgtgct tgagacgatt 1036081 aaactgcttg tcaatgagca gctgaacgtc ccgctcatcg gtttctcagg tgcgcctttt 1036141 acgcttgcaa gctatatgat cgaaggcggc ccgtcgaaaa actacaataa aacaaaagcc 1036201 ttcatgtaca gcatgccaga tgcatggaat ctgctgatgt ccaagcttgc cgacatgatc 1036261 atcgtgtacg tgaaagcgca gattgaggca ggcgcaaaag cgattcaaat ctttgattcg 1036321 tgggtcggcg cattgaatca ggcagattac agaacataca tcaaacccgt gatgaaccgg 1036381 atcttttcag agctcgcaaa ggagaatgtg ccgctgatca tgtttggcgt tggcgcaagc 1036441 catcttgcag gtgattggca tgaccttcct ctcgatgttg tcgggcttga ctggagactc 1036501 ggcattgatg aagccagatc aaaaggaatt actaaaacag tgcagggcaa cctggacccg 1036561 tccattttgc ttgcgccatg ggaagtcatt gagcagaaaa cgaaggaaat acttgatcag 1036621 ggtatggagt cagacggctt cattttcaat cttggccatg gggtatttcc tgatgtcagt 1036681 cccgaggttt tgaaaaaact gacagcattt gtccatgaat attcacaaaa caaaaaaatg 1036741 ggtcaatatt cctaagcata tcttttggta tcttaatgat atcctgtcaa aatgtttgta 1036801 tcagatcatt aaagagggtg taaacagtga gtagaaagaa aatggggctt ctcgtgatgg 1036861 cgtacggcac gccttataag gaagaagata ttgaacgtta ttatacacat atcagaagag 1036921 gcagaaagcc tgaacctgaa atgcttcaag atttgaaaga cagatacgaa gcgattggcg 1036981 gcatttcacc gcttgcccaa atcacagaac agcaggcgca taatctggaa cagcacttga 1037041 atgaaattca ggatgagatt acgtttaaag cgtatatcgg actgaagcat atcgagccgt 1037101 ttattgaaga cgccgtagca gagatgcata aggatggcat tacagaagca gtcagcatcg 1037161 tgctggcgcc gcatttctcc acgttcagcg ttcagtccta caacaaacgc gccaaagaag 1037221 aggctgaaaa actcggcggc ttaacgatta cgtcagttga aagctggtac gatgaaccga 1037281 agttcgtgac atattgggtt gaccgagtga aggaaacata tgcgtcaatg cctgaggatg 1037341 aaagagaaaa cgcaatgctc atcgtatccg cacacagcct gccggaaaaa atcaaagaat 1037401 ttggagaccc gtacccggac cagcttcatg aatcggcgaa attaattgct gaaggcgcag 1037461 gcgtttccga atatgctgtc ggctggcaaa gtgaagggaa cacgcctgat ccttggctcg 1037521 gacccgatgt tcaggattta acacgtgatt tattcgaaca aaaaggctat caagcatttg 1037581 tatatgttcc tgttgggttt gtcgcggatc acttagaagt gctttatgat aatgattatg 1037641 aatgcaaagt ggttactgac gatatcggcg caagctatta ccggccggaa atgccaaatg 1037701 ccaagcctga atttattgat gctttggcaa cagtcgtatt aaaaaaatta ggacgttaaa 1037761 gaaggcgatg aacatgagtg acggcaaaaa acatgtagtc atcatcggcg gcggcattac 1037821 cggtttagcc gccgccttct atatggaaaa agaaatcaaa gaaaagaatc tgccgcttga 1037881 gctgacactt gttgaggcaa gtccgagagt cggcgggaaa atccagactg tcaagaaaga 1037941 cggctatatc atcgaaagag ggccagactc atttctggaa cgaaagaaaa gcgccccgca 1038001 gcttgttaaa gacttaggtc ttgagcattt gcttgtcaac aatgcgaccg ggcaatccta 1038061 tgtgcttgta aaccgcaccc tgcatccaat gccgaagggc gctgtaatgg ggataccgac 1038121 aaaaattgcg ccgtttgttt ctacgggtct gttttccttg tccgggaagg cgagagctgc 1038181 tatggatttc atcctgcctg caagcaaaac aaaggatgat cagtcattgg gagaattctt 1038241 ccgcagacgt gtcggagatg aagtggtcga gaacttaatc gagccgctac tatcagggat 1038301 ctacgcaggc gacattgaca agctcagcct gatgtcgaca tttccgcaat tttatcagac 1038361 ggaacaaaag catagaagcc tgattctcgg catgaaaaaa acaaggcctc aaggctcagg 1038421 ccagcagctg acggcaaaaa aacaagggca gttccaaact ctgtcaaccg gtttgcagac 1038481 ccttgtagaa gagatcgaaa agcagttaaa gctgacgaag gtgtataaag gcacaaaagt 1038541 gaccaaactt agccatagcg gctcttgcta ttcgctcgaa ctggataacg gcgtcacact 1038601 tgatgctgat tcagtaattg tgactgctcc gcataaagcg gctgcgggaa tgctttctga 1038661 gcttcctgcc atttctcatt tgaaaaatat gcactccaca tccgtggcaa acgtcgcttt 1038721 aggtttccct gaaggctccg tccaaatgga gcatgagggc acgggttttg tcatttcaag 1038781 aaacagtgac tttgcgatca cagcctgtac gtggacgaat aaaaaatggc cgcacgcagc 1038841 gccggaaggc aaaacgctgc ttcgggcata tgtcggaaaa gccggagacg aatccattgt 1038901 cgatctatca gataatgaca ttatcaacat tgtgttagaa gacttaaaga aagtcatgaa 1038961 cataaacggc gagccggaaa tgacatgtgt aacccgatgg catgaaagca tgccgcagta 1039021 ccatgtcggc cataagcagc gtatcaagga gctgcgtgaa gcacttgcat ctgcgtatcc 1039081 gggtgtttat atgacaggcg cttctttcga aggtgtcggc attcccgact gcattgatca 1039141 aggaaaagct gccgtgtctg acgcgcttac ctatttattc agctaaaacc tccgctttat 1039201 cgcggaggtt tttttgatgt gcaatggcaa tattgtgtaa aaaatgattg aattgaacag 1039261 caggttatga tacatttgca tatgtactta atgactaaaa tgttcaaacg gtcagtttcg 1039321 aggtgaatac aatgtcaata gatcgaaaaa agctcatttt ggaggcggct acaaagtctt 1039381 tcacgcagtt cgggtataaa gcgacgacaa tggatcttgt cgcaaaactt gcgaacgtgg 1039441 ggaagggaac catttatact tttttcaaaa acaaagaaga gctgtttgac gagattttca 1039501 ctactttatt aaaggaaatg aagcaaaaag cggatgaagc gatggagccg agccttccgt 1039561 tccatgaaaa tgtgcacaga gcgctgtttg ccattctgga gttcaggaaa acacatcagc 1039621 tgacgattaa aattttccaa gagaatgccg agattggtac aatggcagtt caggaagtga 1039681 tccagaaaat ggagcgatcc atcctgtctt atatcaaaag caagattgaa gacgggatca 1039741 aaagcggcgc aatcaagccg tgcgaccctg agctgacagc ctttgtgatg ctgaagcttt 1039801 atatcgcgct catttttgac tgggaaaaac aacacccccc gcttgataaa gagacaattg 1039861 cgggactgct tgaattgtat gttgtcaaag gattgtcagc gaactagata atcctttctc 1039921 tttgcaagaa aatgaccatt ttttatgatg agtcagtttt agaatggagg catcaggatg 1039981 aacacaatac gaagtcagtg gaaagacatc gtaacaagta aaaaattatt gattcccatc 1040041 atcgccattt tgtttgtccc gcttatttac agcggcgtat tcttaaaggc ttattgggac 1040101 ccgtacggca cagttgacca gctgcctgtc gttgtcgtca accaagacaa gggagcaacg 1040161 tatgaaggag aaaaacttca aatcggtgat gatctggtca aagaattaaa ggataataac 1040221 aactttgatt ggcatttttc caatgatctc gaccaatcgt taaaggactt attgaatcaa 1040281 aaatattatt tagttgtcga gattcctgag gatttttcta agaatgccag cactgtatta 1040341 gacaaaaatc cgaaaaaatt ggatctgaaa taccatacaa atgcaggttc taactatgta 1040401 ggggcaacga tcggcgaaaa agcgattgat aaactgaaag cctctgtttc aaaagaagtg 1040461 accgagcaat atacgaaagt tatttttgat aactttaaag atatcgcaaa aggtttgagc 1040521 gacgcgagca gcggcgcgaa aaaaattgat gacggcacaa aggatgcgaa aaacggaagc 1040581 gcccagctga aagaaaatct ggcgaagctg aaggaaagca ccgctaccat cagtgacaaa 1040641 acagcgcagc ttgcagatgg agcggctcag gtgacgagcg gcatccaatc acttgacagc 1040701 tcgctcggta aattccagga cagcagcaac cagatttatg ataaatctag tcagcttgca 1040761 gcaggatcag gcgagctgac aagcaagatg aatgaacttc ttgccggact tcaaaatgtg 1040821 cagaagggta cgcctaatct tactaacggg ttggatcagc tcaacagtaa agtccaagaa 1040881 ggttctgaga aagcggcaaa agcggaaaag atcattaatg cgctcgattt aacgaagctt 1040941 gaaactgctg taaacaatct ggaaaagtca gaaactgcga tgaaggaatt caaaaaacag 1041001 ctgactgact ttgaaaacag tttgaaaaac cgtgatcagg catttaaaaa tgtcatcaat 1041061 tcgagtgact tcttaacagc ggagcaaaaa agccagctga ttaattctgt tgagaaaaag 1041121 cttccgcaag ttgatgcgcc tgattttgat caaatattaa gccagctacc tacagctgat 1041181 cagctgcctg acatcgcaac gataaaaagc tctcttgaag acgtgaaagc gcaggtggcg 1041241 caggtgaaag ccatgccgga agctacatct aagctttata acggcgcaaa aacaatccaa 1041301 gatgcgattg acagattaac tgagggagct gataagatat acaacggttc tcagaagctg 1041361 acagatggcc aaactaaact gacagcgggc atcggtgaat ataataagca gttcgcaaaa 1041421 gcaaaagcgg gctcagagca attggtgaca ggaagcagcc aagtatccgg cggattgttt 1041481 aagctgttag acgggtctaa acaggtccaa agcggatcat caaaacttgc agacggatct 1041541 gcatcacttg atacaggttt aggcaagcta ttggacggca caggagagct gtctagtaag 1041601 ctgaaggatg cggctgacca aacaggagat atcgatgctg atgatcaaac atacggcatg 1041661 tttgcggatc cggttaaaac caaagatgat gccattcatt ccgttcctaa ctatggaaca 1041721 gggctgacac cttatatcct gtcaatgggc ttgtatgtcg gcggcatcat gctgacggtt 1041781 gtcttcccgc tgaaggaagc gtcaggacgt ccgagaaacg gttttgagtg gttcttcagc 1041841 aaattcaatg tcatgatgct tgtaggaatc attcaatcat tgattgtggc gacggttctt 1041901 ctattgggaa ttggtcttga ggtagagagc acgtggagat tttacgtgtt tacgatcatt 1041961 acgagtctcg ctttcctggc gataattcaa tttttggcta caacgatggg caacccgggg 1042021 cgatttatcg cagtcattat tttagtgctg cagctgggag cgagcggagg aaccttcccg 1042081 ctggaattgc ttccgaattt ctatcaggtc atccacggcg cattgccgat gacctacagc 1042141 attaacggat tcagagcagt catttcaaac ggtgactttg gctacatgtg gcagatggcc 1042201 ggcgtcttaa tcggcattgc cctcgtcatg attgcactaa gcattactta ctttacaatg 1042261 ttaagccgga aggaagaaac atcagaagaa cagccggctt cataaagaaa aagaacttgt 1042321 ttccttggaa acaagttctt tttttgttac atcccccatt taataagcaa tcctgtatag 1042381 gttaatccgc cgccaaaccc gaaaagcaaa acgatttgat cttttttcag cttcccggct 1042441 ttcactgcga gatcgagcgc caaaacaatt gaaaccgaag acgtgtttcc gtagtgctca 1042501 acactagtga gcgttttttc aatcgggaac ggtgtttttt cacaaattga ctcgatcatg 1042561 cgcaagttgg cgctgtgagg aacaaaccaa tcgagatcat cggagctgag tcctgcttta 1042621 tgtaaaagcc gttcaaattc gccagggacg gttcttgcgg cccatttata tacctcgcgt 1042681 ccgttttgca ccatttttcc ggaaccgaca agctgcacac cgtttatttc atttcgcagt 1042741 ccggcacgat acaaaatatc gccgccgttc ccgcttgttc cttgtacaga cgcaagaaat 1042801 cccggcgtct cttcatctcg ttctactaac agcgcacccg cggcatcgcc gaacagtacg 1042861 catgtcgttc gatcggtata atcggttacc tttgataacg tctctccggc gatgacgaga 1042921 attttttgat gaaggccaga tgtgatcaat ccatttgcca aatggaggcc gtatgtcagc 1042981 ccggcgcatg tcgcattaat atccagcgcg ccggtgcttt cccagccgaa atattcctgt 1043041 acgcggcatg ccgtactcgg aaaggcgtaa tcggatgtgg ttgtggcaac gaggatcata 1043101 tcgacatcat caagcgttcc tttataacgg ctcttgagat tcttcaccgc ttctatgcat 1043161 aaatcagagg taaattgatg ttcatccgca atccggcgtt ctctcattcc tgtgcgctga 1043221 acgatccatt catcagaggt atcaacgatc ttttctaaat ctgcattggt taaacgtctg 1043281 ctcggcgcat aggtgccgat agctgtaatt tttgcttttg acatatgaat cactccttat 1043341 ggtcagatta taacactaga tattagtatc tggtactaaa aagaaggttt ttttacaaaa 1043401 aaagagaagt gtagatagga atctatgaaa aagaaaaagg aggctgaaaa atggtcagtc 1043461 aagaagcagt agtctttttg gcattatccg gggctattgc gtttctgttg ccaatcgggc 1043521 tgattgtatg gtttaagcga aagtatggtg cctcgcttaa agtgtttttt attggcgctc 1043581 tcacgttttt tgtcttcgct cagctgctgg aaggcggcgt tcatgtttat gtactgcaag 1043641 tgaatgaaat gacgaaagaa gcgatgcagc atccattatg gtatggcatt tacggctgct 1043701 tgatggccgg catttttgag gagtgcggaa ggtatttgat gatgcgattt tttatgaagc 1043761 gccatcatac ttgggcagat ggtctggctt tcggggcagg ccatggcggg cttgaagcca 1043821 tcctgattac aggcttgtcc tctatctcac ttattgtata cgcatttgca atcaatagcg 1043881 ggacgtttga acagcttttg gtcaatggcg acgtcaaaca ggcgcttttg ccgatacagg 1043941 agcagctgct gcatactcct tcgtatgaat ggatgctggg cggaatagaa agaatcagtg 1044001 ccattgccgt ccagattggt ctgtctctgc ttgttttgta cgcggttaaa aaccgccggc 1044061 cgctgttttt gctgtattct attcttttac atgcactgtt taatgtcccg gcggttttat 1044121 atcaaagagg aatcatagag catgctgcag ctgttgaaat cattgttgct cttatagcgg 1044181 ctttatcagt ttattggatt gtaaaagcaa aaagggtgtt tcaataaaag gtccaagcag 1044241 cagcaatgcc cgcttggaaa aatgtgaatg gaaatattca ttaagcatgg gtcatcagaa 1044301 tatttctgat tcagtcttta gcaatgacag caagaatgtc tgtgtttttt acaagagaaa 1044361 caatggtgtt tctttttctt cttctcgcaa gggtcatggc attctttctt tttcttgcaa 1044421 tggtcgtgga aatctttatc gaaccactcg tcaaagaacc aaaaatcatc gaaccaatcg 1044481 tgacaacgac atttctgttc atgtgaatga cgacagcaca tagaaatccc tcctcttccc 1044541 atgctctcta cagcatatga gagattgata ggaaaagatt ggacgggtcc ctcgggaaaa 1044601 gagtatattt taagtagaaa ataaaaggag gaatgcccta tgacgtccgt acgtaaaacg 1044661 atggagctca ttaaagaact tgtatcgatc ccaagcccga caggaaatac atatgaggtg 1044721 atcaattata ttgaaagcct tttaaaagaa tggaaggtag aaacggttcg gaaccacaag 1044781 ggcggcttaa ttgcaacgct tccaggacgc gacacatccc ggcatcgcat gctgacagcg 1044841 cacgttgaca ccctcggcgc tatggtgaag gaaattaaag cggacggccg gctgaaaatc 1044901 gacttaatcg gcgggttccg ctacaactcg attgaggggg agtattgcca aattgaaacc 1044961 gcctcgggaa aaatgtacac aggcacaatc ttaatgcatc aaacgtctgt gcacgtatac 1045021 aaagacgcgg gaaaggctga gcggaatcaa gagaatatgg agatccgcct agatgaacct 1045081 gttcactgcc ggaaagatac ggaggagctt ggcattggcg tcggagactt tgtgtcgttt 1045141 gatccacgtg tcgagatcac atcaagcgga tttattaaat cgcgccattt ggatgacaaa 1045201 gcaagcgtcg ccttattgct ccgcttaatt catgaaattc aaacagaaga cattgagctg 1045261 ccgtatacaa cccattttct tatttccaat aatgaagaaa tcggttacgg cgggaattcg 1045321 aatattcctc ctgaaacagt tgaatatttg gcggttgata tgggcgctat cggtgacggg 1045381 caggcgacgg atgaatattc agtatcaatc tgtgtgaagg atgcgagcgg gccgtatcat 1045441 tatcagctca gaaagcattt agttcaatta gccgagaagc atcatattga ctataagctt 1045501 gatatatatc cgtactacgg gtctgatgcg tcagcagcga tcaaatccgg gcatgatatt 1045561 gtgcatggcc tcatagggcc gggaattgac gcttcccatg catttgaacg cacccataaa 1045621 tcatctcttc gccataccgc taagcttctg tattactatg tacagtcacc aatggtataa 1045681 gggggaggac caatgaagat ttataagctg aaaagcacat tcggttggga aggtgatgac 1045741 gggttgggag aacagctgat tcagcagatc cttgccggag aaaaaagcgc cacgtgcgcg 1045801 ccgaaatcat tgtattcaaa agatgaattg agggacgttt atcaaacagc gggtcagctt 1045861 gttaccgttt atgataaaca tgacaatcca agatgcaata taaaagtaac agatgtcttt 1045921 gaaaccacct ttggtgcgcc tgatatgagg ttagtcaaag gagagggcaa tggagaccga 1045981 attgaggagt ttcaagagga tcatcggatg gcatgggcgg aactgatcaa aagcggtgaa 1046041 ctggagctga atgaggatac tgttttgatt acagagttgt ttgtgcttgt taaagattaa 1046101 aaaagcctgc ggggcaagaa ccccgcaggc ttttcattaa ccagaaatgg ttgcgttttg 1046161 ttctgttttc gattgggaca taacagtttc tgctttcgca ggattaaaca tgccttccca 1046221 tttagacatc acaacggcag caagcgcgtt accagtcagg ttgacaactg tacgtgccat 1046281 atccatgatg cggtctacgc cggcaataaa ggcaagtcct tcagccggaa cgccgatggt 1046341 gccaagcgtt gcaagcaaga caacaaaaga agtaccaggt acggcagcca tccctttgga 1046401 tgtcaccatt aagacgagca caagcgtaat ttggtgccaa atcgtcaaat caatgccata 1046461 tacctgtgct aaaaagagtg cggcaataga ttgatagaga acggaaccgt ctaagttaaa 1046521 cgtgtaaccg atcggaatga caaatgaaac aatgcctttt ggacatccga ttttctccat 1046581 tttttccatg atacgcggaa gaaccgtttc agagctggac gtactgaacg ccagtaagat 1046641 ttcgtccttc atgtaagcaa ggaacttgaa gatgctgatg ccggcaattt ttgcgacaat 1046701 cccgaaaata acaattaaga agaaagcaag cgcgacataa accaatccga cgagctttcc 1046761 gagagagata agagaaccga gtccgaattt agacacagtc actccgataa gagcgaaaac 1046821 gccgaatggc gccactttca tcacaaggtt tacaacgtgg aacatggcat gggatacacc 1046881 ttcaaaaaag gctaatacag gcttgcctct ttcaccgatc gcggaaatac ccaatgcaaa 1046941 tagtactgta aagcagatga tggctagaag atccccttcg accaatgact ggaagaagtt 1047001 tgtcggcaca atatggagga acgtttccgc cactgattta ttactttgtt ctttttcagt 1047061 ttcaacatat tgactgatgt ccgatttttg agcttcgtgt atattaactc ctgtacccgg 1047121 atggaagatg tttgcaaggg ctagtccgag aataatggca aaagtcgtga tgatctcgaa 1047181 gtacagaatc gttctgaagc ctaatttacc gacttgcttt ccatttcctg caccggctac 1047241 accgatgatt aagctggaga caacaatagg aatcactatc attttgatta agcgtaaaaa 1047301 gagatccccg attggctgca ggtaagtagg caatgctggg ttgccatacc aaatgacgcc 1047361 aacaatgaca cctagaataa gtccaacgaa tatttgtgtg gctaatccaa acttaattct 1047421 tttcatagat tacctcccaa aaaacaaagt atcaacatat atcatgaata gacatatatt 1047481 taatctcact attagatcaa attataatag ataagaaatc aattcgtcta tagtaaatta 1047541 tatttcgaaa ataaagaata ttcaatgaca ttatgataat caccagaatt atctaaaaac 1047601 aggtgagctt tgacctaacc tgactattat ttcaaaatta agagatatgt gaaaaaataa 1047661 gaaaatccca cgcgtaaggc gcgggatttt cgctcattac aaatcgttta cttttataca 1047721 gtcattgcag atattaccat aacactcatg ctgctcttct atcttttttc cgcattccgc 1047781 acactttttc gaaggcaggt ttctaaaaaa ttctgtgatt ttccccagca taaccaatcc 1047841 ctctttcccc tttgtagtga tttcattgta atataacaga ttacaaaaat caataactgt 1047901 tttgatacaa tgtttaaaac atgctttttt caagaaaaat gggtatattg aaggaggacc 1047961 aatttttttg aaaagatagg aggacattat gaaagttaca gttatcggat gctatggcgg 1048021 ttttccggcc gcaaatgaag cgacgtcagg ctatttgttt cagtcaggtg attactctct 1048081 gcttgttgat tgcggcagtg ccgtattgtc taagctgttc ggatatgtgc cggcggaaaa 1048141 gctggatgcg gtcgttctgt ctcattatca ccatgaccat atcgctgata tcggaccgct 1048201 gcaatttgcc aagcaagtcg gttcgtttct cggcaaagga gagcatacgc ttccgattta 1048261 cggacatgat gctgatatag aacagtttca aaagcttaca tataaaacac atacaaaagg 1048321 gatcgcctat cagccggatc agccgctgac tgccggtccg tttacgatca cctttttaaa 1048381 aacgattcac ccggtgacgt gctatgccat gcggattact gacggcagcc acactgtcgt 1048441 ttatactgct gattccagct atcaggattc atttataccg ttttcgaaag atgctgattt 1048501 attgatctca gaatgcaatt tttatgccga tcaagacgga acaagtgcag gccatatgaa 1048561 cagcctggaa gctgggcgca ttgcaaaaga agccggagcg ggagaactgc tgctgacaca 1048621 tttgccgcat tttggcgtgc atgacaacct tcgcaaagaa gcgaaaaccg tttttaacgg 1048681 agaagtgaat attgcgaaat caggttttgt gtgggaagga taaaggagga gcaccatgtt 1048741 atttatagac aatcaaaata tcaatgatcc gcggatcaat cttgctatcg aggagtactg 1048801 tgtaaagcat ttagaccctg aacagcaata tttgctcttt tatgtgaatc aaccgtctat 1048861 tatcattggg aaaaaccaaa atacaataga agaaatcaat acaaaatatg ttgaggaaaa 1048921 cgggattatc gtcgtccgcc gtttatcagg cgggggcgct gtgtaccatg atctggggaa 1048981 cttgaacttc agctttatta ccaaggatga cggggacagc tttcataact ttaaaaaatt 1049041 cactgagcca gtgattcagg cgttacatca gcttggggtt gaagccgaat taagcggccg 1049101 gaacgacatt gtagtagatg gccggaaaat atccggaaac gctcagtttg caacgaaagg 1049161 ccgtattttc agccacggca ccctcatgtt tgattcagcc attgatcatg ttgtatcagc 1049221 attaaaggtg aaaaaggata aaattgaatc aaaaggcatc aaatcgatca gaagccgagt 1049281 ggcaaacatc agtgagtttc tcgatgataa aatgaccacc gaagaattcc gcagccattt 1049341 gcttcgccat atttttaaca caaacgacgt tggaaacgtg ccggagtata agctgacgga 1049401 aaaagattgg gagaccattc atcaaatttc gaaagagcgc tatcagaatt gggattggaa 1049461 ctacggccgc tcaccaaaat ttaaccttaa tcattcgaag cgttatccgg ttggatcgat 1049521 cgatttgcac ctggaagtca agaaaggcaa aatcgaggac tgcaaaatct tcggagattt 1049581 cttcggtgtc ggtgatgtat ctgaaattga aaacctgctg gtcggaaaac aatacgaacg 1049641 cagcgtcatc gctgatgtgc tcgaaggtgt gaatctcaag cattactttg ggaacattac 1049701 gaaagaggat ttccttgatc tgatttacta aggcaaaaca catcgtttga aagagcggtt 1049761 gtgtttttga aataatggag gcaggaggga ttcacatgaa agtgttttta atcggagcga 1049821 acggacaaat cgggcaaaga ctcgtctctt tattccaaga taatcctgat cattccatca 1049881 gagcgatggt cagaaaagaa gaacagaaag cgtctcttga agctgccggt gcagaagctg 1049941 tgcttgcgaa tctggagggc agcccggaag aaatcgccgc tgcggcaaaa ggttgtgacg 1050001 cgatcatttt cacagccggt tccggcggca gcacaggcta tgataaaacg ctgctggtgg 1050061 atcttgatgg agcggcaaaa gccattgaag ctgcggccat tgccggaatc aaacggttta 1050121 ttatggtcag cgccctgcaa gcccataacc gtgaaaattg gaatgaggca ctcaagcctt 1050181 attatgtggc caagcattat gctgataaaa ttctggaagc gagcggttta acctatacga 1050241 ttatccgtcc gggaggcctt cgcaatgagc ctggaacggg aactgtttca gcagcgaagg 1050301 atctggagcg gggatttatt tcccgtgatg acgttgcaaa aacggtcatt gcctctttag 1050361 atgagaagaa tacggaaaat cgggcctttg atctgacaga aggagatacg ccgattgccg 1050421 aagcattgaa gaaactatga cagtactgac actcagggct ttttgctctt gagtgttttt 1050481 ttctgtttct ctataatgga gaagaaagct tggcttcaat aatgaatgac tattcattca 1050541 cttaaggggt gggagaatga atcttgtttc aaaattggaa gaaacagcat ctgagaagcc 1050601 cgacagcatc gcatgcaggt ttaaagatca catgatgacg tatcaagagc tgaatgaata 1050661 tattcagcga tttgcggacg gccttcagga agccggtatg gagaaagggg accatttagc 1050721 tttgctgctt ggcaattcgc ctgattttat catcgcgttt tttggcgctt taaaagctgg 1050781 gatcgtagtt gttcccatca atccgttgta cacgccgaca gaaattggtt atatgctgac 1050841 aaatggcgat gtaaaggcaa tcgtgggcgt tagccagctt ttgccgcttt atgagagcat 1050901 gcatgaatcg ctgccaaagg ttgagctcgt cattttatgc cagacggggg aggccgagcc 1050961 ggaagctgcg gacccagagg tcaggatgaa aatgacaacg tttgcaaaaa tattgcggcc 1051021 gacatctgcc gctaaacaaa accaagaacc tgtacctgat gataccgcgg ttattttata 1051081 tacgtcagga acgactggaa aaccgaaagg cgcgatgctg acacatcaga atttgtacag 1051141 caatgccaac gatgtcgcag gctatttggg aatggatgag agggacaatg tggtctgcgc 1051201 tcttcccatg tttcacgtgt tttgtttaac cgtctgtatg aatgcaccgc tgatgagcgg 1051261 cgcaactgta ttgattgagc ctcaattcag tccggcatct gtttttaagc ttgttaagca 1051321 gcagcaggcg accatttttg ccggtgtgcc tacaatgtat aactacttgt ttcagcatga 1051381 aaacggaaag aaagatgatt tttcttcgat ccggctgtgc atttcgggag gcgcgtccat 1051441 gccagtcgcg ttgctgacgg cgtttgaaga aaaattcggt gttaccattt tggaaggcta 1051501 cgggctctcg gaagcatcac ccgtcacgtg ctttaacccg tttgacaggg gcagaaagcc 1051561 gggctccatc gggacaagta tcttacatgt cgaaaacaag gtcgtagatc cgctcggacg 1051621 cgagctgccc gctcaccagg tcggcgaatt gatcgtgaaa ggccccaatg tgatgaaggg 1051681 ctattataaa atgccgatgg aaacagagca tgcattaaaa gacgggtggc tttatacggg 1051741 ggacttggca agacgggatg aggacggcta tttttacatt gttgaccgga aaaaagacat 1051801 gatcattgta ggaggataca atgtgtatcc gcgggaggtg gaggaggtgc tgtacagcca 1051861 tccggacgtc aaggaggcgg ttgtcatcgg cgtgccggac ccccaaagcg gggaagcggt 1051921 aaagggatat gtggtgccga aacgctctgg ggtaacagag gaggacatca tgcagcactg 1051981 cgaaaagcat ctggcaaaat acaagcggcc tgccgccatt acgtttcttg acgatattcc 1052041 gaaaaatgcg acggggaaaa tgctcagacg ggcactgaga gatattttgc cccaataaaa 1052101 tgaaaaagcg aagcggttag cttcgctttt tcattttcaa tcctttgctt cttttttaat 1052161 aatatttagc agcgcctttg tatcattttt gcttaatttg tagtatgtgc catccttcaa 1052221 aaaaacggct tgctggctgc cgtcaatcca tagtctgaat gagtcatacc ggtctttatg 1052281 aaacttgatt gtcccttcgt aatcaggggc tgatgttttt tctgtcttca cctgttttcc 1052341 ctgattcata atatccagca tatctttgac gtgctgtctt ttttcaatct cgatatcttc 1052401 ctggccgctt gaagacagtg tgatcaaatc cgcgtctacc gattgataca catcgcctga 1052461 tcggctgtaa agataaaaaa atgcgataaa cacaagaccg attaccacga tggctgccac 1052521 tatttttttc atttgcatca ctccaaacat tgttagtttt cccagcgatc ggggtttcca 1052581 tgcttaaaag ggtggaaaag tgcggaacac agcttggttc taagaatttg aatttatgat 1052641 tacaatagaa gtaacgggtt gatgtgagga gtgaggcgtt atgcgcaagt ggattgcggc 1052701 agcaggactt gcttacgtgc tgtacgggct gtttttttat tggtattttt tcctgtcggg 1052761 tgattccgca ataccggaag ccgtgaaagg gacgcaggct gatccggctt ctttcatgaa 1052821 gccgtctgag ttggcagtgg ccgagcagta ttcgaatgtc aagaattttt tattttttat 1052881 cggggtacca cttgattggt ttctgttttt tgttctgctt gtcagcggtg tttcaaagaa 1052941 aatcaagaaa tggatcgaag cggccgtgcc ttttcggttt ttgcagaccg ttggttttgt 1053001 gtttgtgctt tcgctgatta caacattggt gacgctgcct ttagattgga taggctatca 1053061 agtatcgctt gactataaca tttccacaca gacaacggcc agctgggcta aggatcaggt 1053121 tatcagcttt tggatcagct ttccaatctt tacgctttgc gttctcgttt tttattggct 1053181 gatcaaaagg catgaaaaaa aatggtggtt atacgcctgg ctgttaacag tgccgttttc 1053241 gctgtttctg ttttttattc agccggtcat tatcgatcct ttatacaatg atttttatcc 1053301 gctgaaaaac aaagagcttg aaagcaaaat tttagagctg gcagatgaag ccaatattcc 1053361 ggctgaccat gtatatgaag tgaacatgtc agaaaaaaca aatgcgctga atgcctatgt 1053421 tacaggaatt ggggccaata aacggattgt attgtgggat acgacgctga acaaacttga 1053481 cgattcagaa attctgttta ttatgggcca cgaaatgggc cattatgtca tgaagcacgt 1053541 ttacatcggt ctggctggct atttgctcgt gtcgctcgcc ggattttatg tcattgataa 1053601 gctttacaag cggacggttc gcctaacccg cagcatgttt catttagaag ggcggcatga 1053661 tcttgcggca cttccgctgt tattgctttt gttttctgtt ttgagctttg cggttacgcc 1053721 tttttctaat gctgtctcgc gttatcagga gaataaggct gaccagtatg ggatcgagtt 1053781 gacagagaac agagaagccg ctgttaaaac gtttcaggat ttggccgtga cggggctgag 1053841 ccaggttgat cctccggtgc ttgtgaagat tttcagaggc agccatccgt cgatcatgga 1053901 acggattcaa catgcggaga aagaagagaa tgcgccggaa catcaggatg ctgacaaata 1053961 aaaagaagca ggtatggagg aacctgcttc tttttactat tattgtgcag ctgcttgtac 1054021 gttgattaac ccttttccat agtagaaaga gtttccaaga tatgttgcag tgctttctaa 1054081 acgatcacgg acttgcgcgt ttgtccaagt cgggtgctta gaaagaatta acgctgctgc 1054141 tccggcaacg tgaggagtcg ccatggacgt tccgttataa gcgccgtaag tgcctccagg 1054201 aagtgtgctt tggatggaca cgccaggagc catcacatca agctcagaac ctgcgctgga 1054261 gaatgaagct ctttggttgc tgctgtttac cgcacctact gcaatagtag aaggatattt 1054321 tgcagggtag ccgactgtgc ttgtgcttcc ggatgaacct tcgtttccgg ctgcggcagc 1054381 aacgacgata ccgctggaaa cggctttgtc aacgactgtt ttcagcgctg tagaaccagt 1054441 aggtccgcca aggctcatgt tgataacatc catattgttg gaaatggccc actcaatgcc 1054501 gttaataatc cagctatatt ggccgcttcc tgttgaatca agcactttta ctgcatataa 1054561 tgatgcgctt ggcgctacgc ccagaacacc gattgagtta ttaagagcgg caatcgtacc 1054621 ggctacatgc gtaccgtgag aactgccgtc ctggtatggg tttgtttcag aaggtacgaa 1054681 gcttgctccg cctctgacgt ttaagtcagg atgagaagag tcaattccgc tgtcgataac 1054741 agctactttt acgttagagc ctgtgtagcc ttgagagtga agagccggcg ctttaatttg 1054801 agaaatgcca taaggaacag attgcgcata ttcatgtgca atatgatctt cttccacata 1054861 tgcaacgctc ggatcttttt tcaattcttt tacagctttt tcatccaatg ttgctgcggc 1054921 cgcgttaaca tacttaaatt gcttttgaac ctttccgcct ttttcagaaa taacatcctt 1054981 tttcttggcg gaactcatgg cactcattgt ctgtttaaat ccgacaatgt atttcttttc 1055041 tgtactgctt tttccggcag cctgcgcaga catgttgctg aacgccatcg taaagattaa 1055101 cgttaacgca aacaacaagc tgatccacaa ttttttgctt ctcactcttt accctctcct 1055161 tttaaaaaaa ttcagagtag acttacttaa aagactattc tgtgaattta ttgtaataga 1055221 tggaataata ttttagtaga cccatttttt tgagatgatt ttatctctat ttaggtatat 1055281 catctctcgc tatttccgta gagactcgaa ataactattt tcatacagaa aagaacgaaa 1055341 atagacatga gtaaatgttc attatgctga aatgtcatgc ttttttaggt taaatgctcc 1055401 tgagtcccgg caaattcctg tcgaaaaaat tcgttcaaat gacctgcgtg tgcttccgtg 1055461 agaacaatgg atattatcgt gatatttttt caaagcatga tgataaaagt attctgaaaa 1055521 ataaacttta cagaaaaggg atagaatgaa aaaattattg agagggagga agaaataaga 1055581 tgaacattcg ccaagcaaag acatcagatg cggccgccat tgcgccgctg tttaaccaat 1055641 atcgggaatt ttatagacag gcatccgatt tgcaaggggc agaggctttt ttgaaagctc 1055701 gtttggaaaa tcacgagtct gttattttga tagcagaaga aaatggagaa ttcataggct 1055761 ttacccagct ctatccaacg ttttcttctg tgtcaatgaa aaggatatac atattaaatg 1055821 acttatttgt cgttcctcat gcgcgtacaa agggagccgg cggccggctg ctttctgccg 1055881 caaaggatta tgcagggcaa aacggggcaa aatgtttaac acttcagact gagcaccaca 1055941 accggaaggc aagaagcttg tatgagcaaa acggctatga agaggatacc ggatttgtcc 1056001 attattgtct caatgtgccg gcgaagtgaa aatggcggct tgatgatttg gttttttgaa 1056061 cgttcttcgg ttacgatata aatgaaaagg agtgtgccga atgtcaacgt tatttcaagc 1056121 cttgcaggca gaaaaaaatg ccgatgatgt ttcagtccat gtgaaaacca tatcaacaga 1056181 ggatttgccg aaggatggtg tcctgattaa agttgcttat tccggcatta attacaaaga 1056241 tggtctggcc ggaaaagcag gaggcaatat cgtcagagag tatccgctta ttttaggcat 1056301 tgatgctgcg ggtacggtcg tctcttccaa tgatccgcgt tttgcggagg gggatgaggt 1056361 gatcgcgaca agctatgagc tcggtgtctc acgtgatggc ggattaagtg aatacgcttc 1056421 ggtgcctggt gactggctgg tgcctttgcc acagaatctt tcgttaaaag aagcgatggt 1056481 gtacggaacg gcgggattta ctgcggcgtt atcagtgcat cggcttgaac agaacggtct 1056541 gtctccggaa aaaggcagcg tgctagtcac aggagcaacc ggcggtgtcg gcggaattgc 1056601 ggtatcgatg ctgaacaagc ggggttatga tgtggtggca agtaccggaa accgggaggc 1056661 ggctgattat ttgaaacagc ttggtgcaag cgaagtaatc agcagggaag atgtctatga 1056721 cggaacgctt aaggcgctgt ccaagcagca atggcaggga gcggttgatc cagtcggcgg 1056781 aaaacagctt gcctcgcttt taagcaaaat tcaatacggc ggatctgtcg cagtgagcgg 1056841 cttaaccggc ggaggagaag ttccggcaac cgtgtatcct tttattcttc gcggagtaag 1056901 cctgctcgga atcgattcag tatattgtcc gatggacgtc agagccgctg tttgggagcg 1056961 catgtcttct gatctcaagc ctgatcagct gctgaccatc gtggacaggg aagtatcatt 1057021 ggaagaaacg ccgggtgcgt taaaagatat tttgcaaaat cgcattcaag gaagagtgat 1057081 tgtgaagctt taacaggatc agcttgcaga gaatgttatt tttctgcaag cttttttgtg 1057141 gacaggatga tcagctgctg aactgctgtg tcgcgaaaca agattttcct gtaagccgaa 1057201 ctttctcttc tcattttaaa aataattggt gataatgatt ctcattccgt gttatactac 1057261 tcttggacat cttaaccata gaaactacca acaggagaga ctggaacata tgaaaaaaac 1057321 actgattatt cttacagttt tacttctttc tgtcttaacg gctgcttgct cgtcttcaag 1057381 cggcaatcaa aacagtaaag aacataaagt ggcggtaaca catgatttag ggaagacaaa 1057441 tgtgcctgag catccgaagc gggttgttgt tcttgagcta ggttttattg atacactgct 1057501 tgatctcggc attacgcctg tcggggttgc cgatgacaac aaagcgaagc agctgatcaa 1057561 caaggatgtg ctgaagaaaa ttgacggcta cacatctgtc ggcactcgct cacagccaag 1057621 catggaaaaa atcgcttcat taaaacccga tttaattatt gctgacacga cccggcataa 1057681 gaaggtgtac gatcagctga aaaaaatagc gccgacgatt gcacttaata atttaaatgc 1057741 tgattatcag gatacaattg acgcttcgct tacgattgca aaagcagtcg gcaaggagaa 1057801 ggaaatggag aaaaagctga cggcgcatga agaaaagctt agcgagacaa agcagaaaat 1057861 cagcgcgaac agccagtccg tgcttttgat cggaaataca aatgatacca ttatggccag 1057921 ggatgaaaac ttctttacat cgagactttt aacacaggtc ggctaccgat atgcaatcag 1057981 tacgtcaggc aatagcgatt caagcaatgg cggcgactct gtgaatatga aaatgacact 1058041 ggagcagctg ctgaaaacag atccggatgt gatcatcctg atgacaggaa aaacagatga 1058101 cctcgacgcc gacggtaaac gcccgatcga aaagaatgtc ctttggaaaa aactgaaggc 1058161 agtgaaaaac gggcatgtat accacgtgga tcgtgcggtg tggtctctgc gccgcagtgt 1058221 agacggggcg aatgccattt tggacgagct tcaaaaagag atgccggctg ctaagaaata 1058281 aaagaaaaga caggcaaacg cctgtctttt tcttatttga taaagccgga taagtggctg 1058341 ttgatattat agtcttttat ccgccatttt tcttctgcaa attcaatgtt gctgaggcag 1058401 gcgttgacga gacgggtgct ttgaagctcc gggtcaccgc cggatatttc tgtcagcagg 1058461 gcgtgaattg ccgcaccgtg cgccacgatc agcaccttct tgtttggata cgcctgattc 1058521 acttttgcca aaccgcccat cagcctgtca gtgagttctt ctaaggtttc catattcgga 1058581 tagatgttat ctggatagcg ctttgtccgt tcctccagcg gcatgccctc cgcgtcgccg 1058641 taatcgcgtt ccttaaaatc atccatctcg actatcggaa gatgcagata ttcattaata 1058701 atttccgcgg ttcttttcgc tcttttcagc gggctcgtca caataatatc ccaagaaaag 1058761 tcctttacat attctccggt ttctcttgct tggcgttcac ctgttgcgtt tagcgggata 1058821 tcggttttgc cttggcattt ttgctgcagg ttccaatcgg tttctccatg tcttactaaa 1058881 caaacggctg tcataaaatc cccttcctga ctttattcat atcgctatta tactaaatcg 1058941 aaagcgtgtg tcctatgaaa aagcctatgc aagaacttca aataataaag ccagtccgat 1059001 tccgccgccg cttccgatgg ctgcaacagc atattgacag tctggccgtc ttttcgcttc 1059061 ataaaacaat ctggttacca gagctgcacc tgatgcaccg tacggatggc caagagctaa 1059121 ggcgccgccg cgcacattga tttttgaaaa gggaatgccg agttcttgcg agcagacaca 1059181 aattttgacg gcaaaggctt cattgatttc aaataaatcg atatcatcag gtgttacatc 1059241 gtgtgtatgt aagagctgac gaatcgcgac aaccggtgcc gcgggcggaa agttggggtg 1059301 aatgccgctg acagcgctgc cgataaaccg aagcacaggc ttaagtccca gggctgctgc 1059361 tttttcttct tccattacca aaagagcggc tgctccgtct gctatgccac tgctgttggc 1059421 tgctgtgact gttccggagc tggtgtcgaa aaccggcttt gcacggggaa taatcgcttc 1059481 tattggccgc gttttcaaaa atgcttcgtc cgtctccaat tccccgagag caacaacttc 1059541 ttcacggtaa aatccttcat catgcgcgtt cctgctgcgt tgatggctga gaagcgcgta 1059601 ctcatcctgc atgcttctgc tgatggaata gcgtgcagcc gtatattctg ccgcaatgcc 1059661 catgtctgga tcgccgatcg catctggaga aaagcgagcc cgttctgaaa aaggggattg 1059721 gctgctgctt tctgagccgc ccgcgatata catcgtgccg gctcccgctt gaataaggct 1059781 gcaggcatag cgcacagctt caaggccgga gccgcactgt ctgtcaattg tcattccggg 1059841 aaccgataaa ggcagtccgg cttgaagggc tgacagtctg gccaggttgc cgcctctgcc 1059901 agtagcgttt ccgagaatga cctcgtcaac ttgatcctct agctttcggc tgagacagcg 1059961 gatgatggga gccgccaaat cctccggcag gaagggcttc agcagtccgt tttgatttcc 1060021 aaagatcgtt cgttttgcat caacaataac cgcattcatt tatactgtac actctcttcc 1060081 agccattttt tcactctgga acgggcaatt tttccgctgc tcgtttccgg caagctgtct 1060141 gcaaacaccc attttttcgg aattttatag gaggctaatt tctgtttaca ccaggctttc 1060201 agtgttctgg cattagcgtt tccaagaatg acagctacag cgatttctcc ccaatactcg 1060261 tcgggaatgc caacgacagc cgcgctttca acctctgggc aggcgagaag cacacgttca 1060321 atttcttctg ggaaaatatt taatcctccg tacacgatca tcccgttttc tcttcctgat 1060381 atgtatagaa agccctcttc atcaacgtag cccatatcat ctactgtcat ccattcatct 1060441 ggtgtgctgc cgttcacata gccggaaaac ctcatcgggc ttttgacaaa tatttttccg 1060501 atttctcctg gctggcagcg ttctcctcca gcgttgcgga tttcgatccg gacattatga 1060561 aaagggcggc ccgctgaatg cggcttccgt ttgctgtctt ccggtgaaga aaacgtcaca 1060621 aaactaagct ctgatgtgcc gtaaaaatcg tacagcttga gatgaggcca tgcagcggca 1060681 agcttcttct tggattctgc cggccagtct gcgccggatg aaatgatttt gacgggactg 1060741 tcgggaaaac cctcaatcct tgcgagggcg tctgtcatcg tcggtacggt atagagaaca 1060801 ctgatggatt cacggcacag ccattccttc gctttggcag gagaaaactt tttcagcaaa 1060861 caaacggttc ctccgagaaa caaagtgctg acagccccat ataggaagtg agaggacatt 1060921 aacgctccgg gaatcagaac cttatcatct gatgaaatcg aaaaatctgt ttctgtacag 1060981 gtaaagctct ccatccatga gcggtgagat cgcgtaaagg ccttcggttt tcctgtcgag 1061041 cccgacgtaa atcccatata aaaagggtgc tccggatcaa tggtaggcaa gggatcagcg 1061101 gctgcctcag aaatatctgc catacagtta tccagcaata caacaggtgt ctggctatct 1061161 gtcagtttgt ttttgaaaaa ggctaaagta accacaagat ccgcattgct tatggacagc 1061221 cgctccttac attcagccgg gctccagcgt gtgtcgatgg gaatggccgt acatccagcc 1061281 gctgcggctc cggcaaacag ctgtaaaaac gcgagactat ttgggagcag gatcgccaca 1061341 cgattcggca tgctcggctg tgaccgcagc caatttgcgg tttgagagac aagccgatcc 1061401 caatcatggt acgtgatttg ctccgattca gtctggatcg ctacacggcc gggcgatgtt 1061461 tcggcagtag atgaataggt atgagtaatt gtcatgtatt gtcatcctcc ttttgtaaac 1061521 atcgtatcag aaagagacaa ggcttgagtg atttttatcg ccagaaatgc agatacagcc 1061581 gcttttatca aatcaccagg cacatatgca aggctcatga aggcggcctg tgacaaatca 1061641 atatgcatga taaaagcttg taccggtata ccaagcagat aaataaagat gatgccgaat 1061701 acgatatgag tgaaaaagag acgcaatact gtcaccttcc gcagcctgtt agcggctaaa 1061761 ctgatcagcc atgaagcgag gggataagca atcaaaaagc ctgcgctcgg tccgaaaaac 1061821 acaccaaaac cgcctcgtcc gccgggcaac agcggcgctc cgaaggcgac gagcagcaaa 1061881 aagacaagct ggcttaagaa agcagacttt ggcctgagaa tgctgcctgc caacatgaca 1061941 ccaagcgttt gcaatgtaat cggaacgggt gtaaaggata agaagagagg gggcataaag 1062001 ccgagcactg ccatcagcgc ggtgaaaatc gcaatatgca tcatgtcgat taatttcagc 1062061 atgtgaaatc ctccaaaaag taatcaaata tggttataca ataaatgcag gtaattatta 1062121 tgtcaactga tttttaattt aagtttacat aatgaacgca aaaaaaccgg ccgtatggca 1062181 gaccggtttt tgatggttat tcttctgtca ggatgacaag cgaatcaacg gaagcggcca 1062241 catgggaaac ggcgcggctg acttcctgaa gccctccaag aaaggcttgc agatcgacgt 1062301 cgattttgcc tgattgctct ttgctgattt tcatgctgtg gacgatttca tcgaataagc 1062361 ggttaatttg cgtcattttt tctttacttt cgctgactag ctcattcacg tctttgatat 1062421 gcttggatac aatgttgatt tgtgtattcg tattgttcac aagctcagaa acagtagaga 1062481 cggttttttt cgtatcctca gaaagcttcc gcacttcatt tgccacgaca gcaaagcctt 1062541 tgccgtgttc tccggcgcgg gcggattcaa tagatgcatt gagcgagaga aggtttgttt 1062601 gttcagctat gcctgtgacg atgccgaaga ttttttcaat ttgctgcgcg atttcatcca 1062661 gcttgaccat ttctttttcg atttggacaa ggcttgtgtc aattttgttc atctgttttt 1062721 gctggacttc tagctctttt tttccgccga tcgacttttc ttcaacagtg ctggatgtta 1062781 cagtgccggc tttggatgct tgagaaatgc cttcagattt gtccacaagc tcttgaactg 1062841 atctgcttgt ttctgaaaac agattggcaa tcgatccaga ggtttcttga attttctgat 1062901 gaagaaggtt tttcttttct tcttgttcat cacgggtctg gttgtactcg ctttgaaacg 1062961 cttcaaggac aagctgctgt tctaagttca agatttttgt tgttgcttta atggctttta 1063021 gcagttcttg ctgatttgta atggacgctt cataaatgtc aatcattgac aaaaggagct 1063081 cttgaaacgc acccatatac cattttggca aaaggccgat tcttaaatgg atggaggcga 1063141 ttcggttacg cttttcaata aattcatcat cgataacgcc tgcaaacatt tcctgaatat 1063201 gccgttttaa cgtttgtttt aagcggtcaa ctgagctgtg atcattaatg atatccatca 1063261 atgagctttc atggtcaagg tttttataaa acgcatcgac gatatttacg atattttctt 1063321 gaatgagtgg ctgaagctgc tctaacacat aaagctcagc atctcccaac ctgaccattt 1063381 tgagctgttt tttgacatct gcatgtttgt ttgtgagctg aatgcggttt ttttgttgtc 1063441 cgtttgaatc tgaaaagtaa gctgtttctt gttttctgtc ttttttaaat aacaatacaa 1063501 tgatccccct tgggaaaaat ataattttta ctttttggct ttttaagcct ttttcttttt 1063561 tatcggccaa gggaaacatg aatgaagctg cagatgaaaa atatttgaaa aaacgttcat 1063621 taaaatgaac ggtttaatcg agatctattt gttttaatgg tttaatggcc ggaccctcta 1063681 caacttcgcc agatggctta aagcgtgatc cgtggcacgg acaatcccac gtatgctcac 1063741 tgtcgttcca ctcgacctcg cagcctaaat gggtacaagt cgtatcaacg agatggaggc 1063801 agcctgtctc atcacgaaat gctcccgctc gcctgccgtt tatggtgacg gctttccctt 1063861 ctcctggcga aatgtcttca aattggacat caggcttttc aagctttcct tttatcaaat 1063921 gcttggcgac atctgcattg taggaaatca ctttctgcaa cccgggattc agatggaaac 1063981 gggacggcgt gaaaatgctt tcgtatgggt tttctttttt ctccacaagg tctgacaata 1064041 aagtggctgc gactgctgag gacgtcatgc cccatttttt gaacccggtc gctactagaa 1064101 tattgtcctc attttccgac atcggcccga taaacgggat tttgtcgatc gtcactagat 1064161 cttgggtgga ccaataatat ggaatgcttt cgatgccgat ggtgctttcg gccagttgtc 1064221 tcagtgtttc ataatgtgta gacatggctt ttccctggcc tgttttatgg cttactccgc 1064281 tgaagagaat cagcttttca ccgtttacaa ccgtatagcg gagcgccact gacggctgat 1064341 cgatactcaa atacatgccc tcgggatact cgatcttcgg cttgatggca aggacataag 1064401 atctgtcgga gtacattctc gcagcatata atccgcctcc gtcataaaaa gggaagtggg 1064461 aacagcatat gataaagcgg ctcttaatgg cgtgccggct ttttgttacc acttcgggcc 1064521 tttcgccttt tttgatatca agcgcaacgg tctcttcata aattcggccg cctttttgaa 1064581 caatttgctc cagaagcgct tttaagtatt gaagcggatg aaattgagct tgattcttca 1064641 tgacaagcgc cagcttagaa cctaagggaa ttggaagatc cttgataagg tctctttcaa 1064701 ttccgagctt tgtgtatgcc tcatgctcgg tgtggatttt ttgaacagcg ttttcatttg 1064761 ccgtataaag atatgcgtct tgctcgatcc attcacaatc aatttgatgt tcatccacaa 1064821 tgccttttat gtaatcaatt gcgttttggt ttgcttcata ataaagcctc gcatggttta 1064881 atccgaaatg gcggataaat tcgtcgtata tcatgtcatg ctgtgcggta actttagcag 1064941 ttgtatgcgc agtggttccg ttaagaacct gatttgcttc aatcaaaacg acacggaagc 1065001 ctctcttcgt aagttcatat gccgttgtga ttcccgtaat cccgcctccg ataatggtga 1065061 cgtcacattc agtgtcctct tgaagcgcag gaaaagaagg caggtcagtt gatgttttcc 1065121 agtatgtttc aggtgcttcc tttgcaaaat gttgattagc caagccgtta tacctccaat 1065181 cagatttatt cttaattttt ccatattcta tcttttcata cataggaagc aggcattgtt 1065241 cataacataa taaggttgaa aaggagtgat ttcattggcg aatcaaaaaa agaaaacatt 1065301 accgcctcag caccagaacc agcagcctgg ttttgaatat ctgatggacc cgcgtccggt 1065361 ttttgataag ccgaagaaag cgaaaaaatt agagggcaaa accgctatta ttactggagg 1065421 agacagcggg attggacgcg ctgtctcggt gttattcgca aaagaagggg ctaatgtggt 1065481 cattgtgtat ttgaatgaac atcaggacgc cgaggaaaca aagcagtatg tagaaaagga 1065541 aggggtaaaa tgcctgctga ttgcaggaga tgtcggggat gaagcgtttt gcaatgatgt 1065601 ggtcgggcag gcaagccaag tgtttccatc cattgatata ttggttaaca atgcagctga 1065661 gcagcatgtc cagcccagca ttgaaaaaat caccagccac cagctgatca gaaccttcca 1065721 aacaaacatt ttttccatgt tttacttaac aaaggcagtg ctgcctcatt taaaaaaagg 1065781 gagctctatt attaataccg cttcaattac cgcctataaa ggcaataaaa cgctgatcga 1065841 ttattcagcg acaaaaggcg cgatcgttac gtttacaagg tccctttccc agtcgcttgt 1065901 tcagcagggc atacgggtca atgcagtggc accgggtccc atttggacac cgcttatccc 1065961 ggccagcttt gccgcaaaag acgtggaagt gtttggttca gacgtgccga tggaacgccc 1066021 ggggcagccg gtcgaagtgg cgccaagcta tctatacctt gccagcgacg attccacata 1066081 cgtcacaggg cagacgattc acgtcaatgg cggaacaatt gtgaacggat aataaaaagc 1066141 caatccttga aggattggct tattcgctct gcttgagcgc tgcatattct ttagagagcg 1066201 taagaaacgc atctttatct ttttcgtcca aggctttgtt aatttggtcc gtcagcatgg 1066261 caagccgacg gttatacaag gattcatcga gcaccatttg aatgtaaata tccgtcattg 1066321 tgacatcgaa ttcttttgtt ttttgcgtgt tgcgggactt catgagctca gtgtacgatt 1066381 ttttctcttt cataaagaat ccccccaatg ccttttttat agtatatgga taacggtcga 1066441 aaaaatcaat aaatttttat aatttttaga caactaatac ttggcaatct atcgacatat 1066501 cctgcaaaat gccgtaaacc ggcaagtctt atgaaagtaa aatcggttta ttactagtca 1066561 tttagtacca ttaaatatca ttaaaagatg attttatctt aaatgttaaa aaaacctgtc 1066621 gttttacaaa aacagatgat agattattag tataaatttt gcagaaaaag gatggaggcc 1066681 ataatatgag tcagaaaaca gacgcacctt tagaatcgta tgaagtgaac ggcgcaacaa 1066741 ttgccgtgct gccagaagaa atagacggca aaatctgttc caaaattatt gaaaaagatt 1066801 gcgtgtttta tgtaaacatg aagccgctgc aaattgtcga cagaagctgc cgattttttg 1066861 gatcaagcta tgcgggaaga aaagcaggaa cttatgaagt gacaaaaatt tcacacaagc 1066921 cgccgatcat ggtggaccct tcgaaccaaa tctttttatt ccctacactt tcttcgacaa 1066981 gaccccaatg cggctggatt tcccatgtgc atgtaaaaga attcaaagcg actgaattcg 1067041 acgatacgga agtgacgttt tccaatggga aaacgatgga gctgccgatc tcttataatt 1067101 cgttcgagaa ccaggtatac cgaacagcgt ggctcagaac caaattccaa gacagaatcg 1067161 accaccgcgt gccgaaaaga caggaattta tgctgtaccc gaaagaagag cggacgaaga 1067221 tgatttatga ttttattttg cgtgagctcg gggaacggta ttagaaaaat aggaaggagc 1067281 tgaccgaaca gggcagctcc tttcataaag ctatgccgtc ggaattcctc cggtgatgcc 1067341 atatacctga gatgtcacat agcttgaatt ctctgaagct agaaatacat aaacatcggc 1067401 caattccact ggctgcccag cgcgatttaa tggagctggc ggcgtgcctt gtccgaattt 1067461 cgggatgttt tccgtcggct gtccgccgga aatttgcagc ggtgtccaaa ttggtccggg 1067521 cgcaactgaa tttactctga tgcctttgga agcaagctgt tttcccagtc cgacggtaaa 1067581 gccgataatg gcgtttttcg ttgctgcgta atctaacagc atcgggcttg gattatagcc 1067641 ttcaactgag gtagttgtga taattgaagc tccctccggc aaatacggaa gcgccgcttt 1067701 tacaacccag taaagggaaa agacgttcac ttcaaatgtt ttatagattt gttcagtagg 1067761 cagatcttcg atgttttcga ccgcttgctg tttgcctgca acgagcgcta gcacatcaag 1067821 tccgccgagt tcgtgatgcg actgtttgac tagatcttgg caaaaggatt cgtcgctcaa 1067881 gtctccgggg atcagcactg cttttcggcc ttctgcttca atcagctctt ttacctcttc 1067941 agcatctggc tgttcctcgg gcaagtagtt aatagccaca tcggcacctt ctctggcgta 1068001 agcaattgcg gcagcgcggc cgataccgga atcgccgccc gtgacaagcg cttttcgacc 1068061 cgttagttta cctgatcctt tgtagctttt ttctccgcaa tcagggacag gcttcatgtt 1068121 cttttgcagg cctggcggtt cttgatattg ttcgggaaat tcatcatgaa aaaatgcttt 1068181 tataggattc gtaagatttg aatcagacat cagcaacgct ccttttctgt ttggtgtaca 1068241 ttcgtatgtg tacccctgag cataagcaga aaaacatgtt ttggcagttt gaatagtgaa 1068301 ggaaaaagaa aacaagaaaa aacaaagcct tcttccatat ttatcttgtc aaataagact 1068361 atatgaatta tgataaattc gagctataaa tcaactaaat attgggtgtt gggagagtga 1068421 atcgtcatga aaaaagcggc ggcggttttg ctgtcactcg gtctcgtttt cggtttttca 1068481 tacggagctg gccatgtggc ggaagccaaa acaaaggtga aggtctataa gaactgcaag 1068541 gagctaaaca aagtatacaa aggcggagtg gcccgcacat cgaaggtgaa aaacaaaggc 1068601 ggaaaaacga agtacaagcc ttacgtttct aaggcacttt acgatgccaa taaaaacaaa 1068661 gaccgcgata aagatcttat cgcctgtgaa cggtaaataa gaaaaagcaa tctggtgtcc 1068721 agattgcttt ttttatgctt aggccgcctg atcggccgca gcgcttttcg ccttccttgt 1068781 cataaggctg actgccatca tgaccgtgat attcaaaagc agggcgacga tgccgacatt 1068841 caagtctttt gcggcttgcg gcagagccgg aaataaagtg ccgatcgtcg tttccgtcat 1068901 tgtaatataa gtaactgctc cgacacctgc aataatgccg gcgaaagctc cttgctttgt 1068961 caccatatta tgcttgagca ggctgaacaa aagggcgggg aatagctgtg tgacaaggct 1069021 gtagcccatc aaaagcagcg taacgatggt attcccgcct ttgaaggtaa aatacaccga 1069081 aatcagcgca atcaccggca ctaaaaactt agcaagcgcc gatacttgct gttctgtcgt 1069141 gcggggcgcg attaccttgt acacattttt tgcaaacagt gtggaggcgg acattaagat 1069201 catagaccct ggcacaagtg ctgtcagcag tccggcagca ccgataattc cgacaaacca 1069261 agggtcaaat gcttgcagag acagtctcaa aagcgacaaa tccccgtctg cgccattcag 1069321 atctggaact tgcaggatag ccgcaaagcc gacgaaaagg acgaagagca ggaccagctg 1069381 gtacaaaggc atgatgatgg cgtttttacg aaacactttt gggttttcgg ctgaatacga 1069441 agcggaaaac gtgtgaggcc acatgtaaaa accaagcgct gtcaagagta cggttgaact 1069501 gaaccaggcc acactttgtc ccgattcggg gagcgtaaga aagccaggct ttgccgtttc 1069561 aatctgctga aacatgtctt gaaatccgcc gtagtaatga attggcaaat acacacctaa 1069621 aaacagaacg acaaccagaa tcatgatgtc cttcacaacc gatatccagg cagacccgtg 1069681 aatgcctgaa accataacat aaaccgtgat ggaaacagcg ccgatccaga tggcagcggt 1069741 cggggtgatt ttgccgtacg aggtttccga tacaatcagc ccgaggcctt tcagctgcag 1069801 tacaagatag ggaatgagtg cggcgatgcc gaccagtgaa acgagaatgc caagcagcgg 1069861 actgttgtat ttttttgtga aaaaatcaga ctgcgacatc agtttatgct gtttcgcgta 1069921 cgtccaaact gctggaagaa gccagtaaga aaggatgtag gccagacatc cgtaggcgat 1069981 gatataaaag gctggaccgc cttttccgta ggcccagccg ctgccgccga gaaacgtaaa 1070041 agtagtataa atttcgcctg ccatcaaaag gaagacgaaa acagttccga agccgcgccc 1070101 tccgaccgtc cactgctcca ggttcatgtc ttttcctttt tgggcgcgta taccgagaaa 1070161 aatactcaag agcaggacac cgaagatgat gatgagagct gcattcattc tgcttcctcc 1070221 tttttatttt ccttgtcgag gacatacaca atcgccatca gcgcagaggt caaaagagcc 1070281 cacatcacaa tataggcaag aataaacggc atgccgaaca catagggggt caccttattt 1070341 gcaaaaggga tgccgagtaa gattccgata aagggtaaag cggcaagaac gtgaatcagt 1070401 ttcatagaat cctccttcta tttaggattg aggtgtacaa gcctaagcgt actgaaaatg 1070461 atgtcgcaga tatcgcagca catgtcattt tttggagtga aaggctgtgg ttcgaattat 1070521 aaataaattt attttgtttg tatagtgtga attgtctgaa attaatgctc tgaatcgccc 1070581 gaagagggaa cgggcagtat gattcaaaag gctcagagtc tgtctggggc aaatagatag 1070641 tatgttaata attcgctgac ctgctcacgg attcgcggat taaaatagcg atggttttct 1070701 tcataaccgt cgatgacaaa tgtatagagt gtaaaggcct catcgcgttc cgtctcgcgg 1070761 attgcaattt ttcttttcct cagttctttt ctgacctcca tcaaatcctt ttgtgctatt 1070821 tttaatgatt cgctgataag ctgtttataa ggatgcttca attttaatgt gctttcttca 1070881 attccggcga gatcacggtt aaaaatcgta atggccatgg gcaaaaagag agcccgttca 1070941 attaaatcgt atatttcctc ctgcagattt ggcatattga ctccttcttt ctaagggaac 1071001 gtttgttcta tttgtattct atatcggctg gtgaaatgtt tcaagacaga aaaaatcacc 1071061 aaaacttttt agttttctgc tgataatgtg tagaataagg atagacaaac ccggtaagga 1071121 gtataaatgt tggagcattt tttatcctat ttgacacaag aacatttaac tgaattattt 1071181 caaagctata gggctttcgg tccgctcatt gctgtgctgc tgcctttaat tgaagcattt 1071241 ctcccgtttt tgccgctgat cgtgtttgtg gtggcgaata cgaactcgtt tggcttgtgg 1071301 gaaggattca tcctatcctg ggcgggatca actgctggtt ccattctcgt ctttttgatt 1071361 gtccgtcaat acggacagag aaaattgctt ggatttatcc gcagtcatcc gtctgtcaga 1071421 aagctgatgt tatgggtgga aagacacggc ttcggtccca tgtttcttct gctttgtttt 1071481 ccatttacac cgtcagccgc ggtgaatgtt gttgccggtt tgtcaaggat cggaacgcgg 1071541 ccgtttattt tggcggcagc ctcggggaag cttgtcatga tttttatgat cagcttcatc 1071601 ggatatgatc tgcacgcgct gattacacag ccgattcgaa cggtcatcgc cgtattggtg 1071661 atcactgtct tatggtatgt cggcaaaaag gtggagcggt atctgcatgt aagagccagt 1071721 cagcgtgagc atgatggagg gagacagtaa catgaaaaaa cggttttggt ttcttgccgg 1071781 tgtagtgtcc gttgttctcg ccattcaggt taaaaatgct gtctttattg attacaaggt 1071841 agaaggcgtc agtatgaacc cgaccttcca ggaaggaaac gaattgttgg tcaataaatt 1071901 ttcgcatcga tttaaaacca tccatcgttt tgacatcgtc ctttttaaag gccctgatca 1071961 taaagtgctg attaaacggg taatcggctt gcccggtgaa acgatcaaat ataaagatga 1072021 tcagctgtat gtgaacggaa agcaggttgc tgagccattt ttgaagcatt tgaaatctgt 1072081 ttctgccggc agccatgtaa cgggtgattt ttctttgaaa gatgtgacgg gaacaagcaa 1072141 ggtgccgaaa ggaaaatatt ttgtcgttgg agataatcgc atatacagct tcgacagccg 1072201 gcattttggt ccgataagag aaaaaaatat tgtcggtgtg atttctgatg ccgaataaaa 1072261 agacgctaat tgaagaggcg tctttttgta tgccgtttgg aaaaatgtgt tgaagaaaaa 1072321 tttgtaagga gctataatca aaattgttac ctgtgtaaca aaatttatat atttttttga 1072381 ctggagggcc gtttttattg gtttttgttc gtttttcatg aaacaaaagg agtggtgaat 1072441 gatgatgaaa tatgaagcag tgattatagg aggagggccg gttggattta tgctggcttc 1072501 tgagcttgca atagccggag tgggaacatg tgtgattgaa cggcttgaaa aacctgttcc 1072561 gcattccaag gcgttgacgc tgcacccccg aacgctggag cttcttgaga tgagagggat 1072621 tttagagcgg ttcgtatcca agggaagcaa gatacctacc ggacattttt caatgctgga 1072681 tacccgtctg gatttttcag gcttggatac gagctgtcct tacacgcttt tgctcccgca 1072741 gtccaaaaca gaaaagcttc ttgaagatca tgcacgaagc ctgggaacag aggtgtttcg 1072801 gggtgccgag gcgctggcgg ttacgcaaaa cggggaagcg gtccaaacaa tttttaagga 1072861 tcgggacggc agtgtacgga cgatcacaag caagtttgcc gttggggcag atggcgccgg 1072921 gagtaccgtc cggaaacagg cgaaaattga gtttccggga acagacagca ctgtcaccgc 1072981 tgcgcttggg gatgtggtgc tcctttctcc gccgccgtca ggtgtgctgt ccctttgcac 1073041 aaaagagggc ggtgttatga ttgttccgtt atctccagac cgataccgtg tcgttgtgat 1073101 cagcccttat cgcacacaaa cgccgaaaga tgtgcctgtg actgaggaag agctgaaagc 1073161 tgacctcctg cgaatttgcg gaactgactt cggtttaacc gacccttcgt ggatgtcgcg 1073221 gtttgggaac gccgcgcgcc aagcgaaacg gtatcgggac ggcagaatct ttcttgcggg 1073281 tgatgccgcg catattcatt ttccggcggg cgggcaagga ctgaatgtcg gccttcagga 1073341 tgcaatgaac ctcgggtgga aactggcggc ggccatcaaa ggctctgcgc cttcttggct 1073401 tttggacagc taccatgatg agcggcatcc ggcagcggaa gggctcctca gaaacacgga 1073461 ggcacagaca aagctgatcg atttcactca agcaggcctc catttgcgaa gcatgatgtc 1073521 ggagctgctg gccttccctg atgtgaatcg atatgtagcg gggcaaattt ctgcgctcga 1073581 tgtcagatat gaagctgatc gtaccatgcc gccgaatcgt ttgaacgggg caaggctccc 1073641 tgacatgaag ctgattcttt ccgacggcaa ttcggaacgg ctgtacagct ttctccaaaa 1073701 cgggacattc gttttgctgt cattgaggca ggaagctgat gatcatatcg aagtaaaagg 1073761 cttacgtacg gtaaccgcct cgcttgcaga accgaatgaa aagttgcgga atgtgcatac 1073821 catattgatt cgtcccgatg gacatgtagc ctgggcggtg gatgcatcag cgcccgattg 1073881 ttccgaggtg attcaaaaag ggatcagccg ctggttttcc gtcaccagcc gagtataatt 1073941 caattcgatt gtttcatctg taacaaaacg gtatgataga agaaacaatc gaatgaaaaa 1074001 ggatggaaaa cccgatgaac acagatcata cgaaacgcaa tctttttgaa ttgtatgcgg 1074061 agctcattca tcagcaggag aaatgggagg ggcttattaa agccttttta tctgacgaat 1074121 tgaggaagct ggatgtagag cacgggagta aatctcaatt gacgatgaca gaaattcatg 1074181 ttctatcctg tgtcggggac aatgaaccaa ttaatgtcac gtcgatagca gaaaaaatga 1074241 atacgacaaa agcgactgta tcacgcatca gcacaaaatt gctcggcgca ggcttccttc 1074301 acagaacaca gctcagcgat aataaaaagg aggtctactt ccgattgacg cctgctggaa 1074361 aaaagctgca cagtttgcac aaatattatc atcagaaggc tgaacagcgt tttctgtcat 1074421 tttttgaccg ctataccgag gaagagattc tttttgcgga acggctgttt cgggatctgg 1074481 tgacaaaatg gtatccgtcg tcagaagaaa ttgaaggggg gcttcctagc atttttaaat 1074541 aaaaaacacg cactgcggtg cgtgtttttc gctttgtttc tatctttttc aaggctgtaa 1074601 cgtaaatcag atttcctctt gaagaatgaa attcaagatg ttcaggaatt tgcactgctt 1074661 atacgatatg tctattagta tctttatttt atacgttttc tactgtgttt ttgatgcttt 1074721 gttttcaagt gaaatagggt cttctgtttt agttctccta atctttacag aaatacctac 1074781 tagaatgacc gccatagttg taaatattcc catggttaat aagatcgtat cctggtttaa 1074841 actccatcca attaagaaag agatgatcgc tcctccgaaa cttgccgagg caataaataa 1074901 acttgtaact tcgtcaacgt acttctgaat aatgattgat gctagtgtta aagcaatggg 1074961 aaatatcccc gctatactta ggccaatcaa aaatgtacca ctcaattgaa gtattgggtt 1075021 acttatataa gagaaggcaa tcaacaaaac aattaaacaa ctacagctaa aaagaaggta 1075081 tttggaaaaa tcaagccttc tacttacgaa accaatcaat attcttccta tgatgatccc 1075141 tacccagaaa aaggagacac ttataagact aatttgttca ttgtcttggt ttatcatgat 1075201 tgaaggtaaa aagttggcaa aatttgtttc aattccagca tataggaaag cgaaaaatac 1075261 aaaaaagcct aattgctttg atttttttct atctcctata aagtattgaa atgctcctcc 1075321 atctggaaag gtcacttgtt ggttagcatt cttagcgtac tctcggttct tagacaagaa 1075381 aattaaccac cctacgaata ggacgaataa aaaggtgaat atacagtaat atggtaaaaa 1075441 ccagttattg atatctatga aggaattaat taataatggg aaagataaag cgcctaatcc 1075501 aaagagaact tccagcttac tcattttttc tgcattactt tcgaaattag caataacaaa 1075561 tgaaccaact gtcgtttcta atgtgcctgc tccatatcct aagagaaaag ccattacaat 1075621 aatataatac caatccttgg ttagaaaaaa gatacttaac gctacaagca ttattgtcaa 1075681 agctaaagta agtgtcctaa aatgactgta tttcttaatc attaaaggtg cgattaatac 1075741 tccgcttaga aatccggtaa actggaagaa gattatgacc gaaatatcat ctgttgtctt 1075801 gttaaaagcc tctaataaaa atggtgtcaa actccctgtt gatatatgga taatacctac 1075861 tgtaaaaaag aaagcatatc caaataaata tgtccctctt aacattcatt acacccctat 1075921 atgaaaaagc aggaaagtaa attcctgctt ttttagtaac ttctctcttt gaaatactag 1075981 ttgactgctg aaacagacat gggttgagag ttgctgtctt tctcaaagaa catttctaat 1076041 acttcctgag atctaaaacc atcactaaaa gaagggatct caacccaatc attctgagtt 1076101 gatgcaatcc aattgattaa ctcgcttcta aaagaatcag cccatccata aaactcgttt 1076161 ggcggatcgt ttaataggct ttgcggtact gggcagtcta ccacgttcaa gccatctatg 1076221 agcttgtaaa cgtgaggatt acctgtgtgg tatttaaact cttttttgtg tccaactacc 1076281 tcaatgctaa aaccacagtc ttcaggtaca gaacactttg atgtgatgat atttacaaat 1076341 accttgttct tcagctggcc ataaatttct gcatagtcat ctacaagtac ctgtttatcc 1076401 tcttttgttt ttacatttgt gttcatcttt gcccttactg attctgtgat gaaatcactc 1076461 tcgaacaaat accataccat gtcaataagg tgaataccca gatcccccaa tgatccactc 1076521 gtcttcttac tattagcgtc atctctccaa gtaaacttct tacgtctaag tgcactattt 1076581 ttcttgaagt gtacttttat ggacagtatg ttacctagtt cattattgat aattaagctt 1076641 tttaagatat ttacgtaaga taaatatcta taattaaatc ccatactggc tcttacgctc 1076701 aacctttcag cagtatcttt cattatgctt gcttcttcaa gagaaatagc cataggcttt 1076761 tcacataata catgcttatg ttttcctaat gcttgcaaag catgttcttt atggcaaaag 1076821 tttggtgatg ctacaattaa accttctgag gcatcaatta gttcatctac gttttcaaat 1076881 gacttcccgc cgaaagtttt cacaaagctt tccgcatttt gttgatttat gtcatatacc 1076941 cctactaact ctgcattttt tattgtagat aaagcagttg catgcgctct tgcaatacca 1077001 cctgcaccta tgatgcctat cttcttcatt tttatttcct cctcatgatc caattaattt 1077061 ttttaaggta ttagtaattc cttttgagta ctcactatca gttataaggt tgtgcaagtt 1077121 tttggcttcc tgtgttgcat tttttagcag atatccattc cctactgtct gtaacatacg 1077181 aacatcattt ccactatccc caaatgcgat agctctttcg gtatttaggt tgtatttctc 1077241 taacataaac gttacaattt cattctttcc tgtccctatg gggataaaat ctacatcata 1077301 gctgtcttct ggatcgcctg ctaagggatt acaccgattt atatttactg aaacgccgta 1077361 ttcttcgcag attttttcaa tagctaatag gtttttcttg tcgtttattt catcttgttc 1077421 ctgatagtag aagttatgct tataccgtga ctttcctaat tgggtttgag gattcaaaag 1077481 aatgttatga ttttcatgca gctgtttcac aagtttttca accttttctt tactaaaccc 1077541 ttcatttatg cgactgttcc acttgttatc ttgctgaccg aagttatgct ctgaaaagta 1077601 cgtaatttca gttccaagat cactagctat aaaatgcgga aaatatctaa attttcctcg 1077661 tcccatttta tcgagaatag attctatact gctcccagta acccatccga ttattagctc 1077721 cccatcttta cttttttgtt ctagatagtc ttcgagttca tagatgtctt gttgcttttg 1077781 ttcgtcgatt gtatgcggaa aatacgtttc atcaaaatca caaaaaacaa tatattgagg 1077841 atgttcaacc gtggataacg ttttatactc cgatttcttg cttaataaca tgaaacagtc 1077901 cctccattac tctgtcttgt tcttctaaag taaatgacgg atataaaggc aaatgcagta 1077961 cctgactatg agccttttcc gtatgaacca attggagtcc tgcatacttg tcctgtacta 1078021 aaggagtttt ttgcatatga gaaagtattg gataatatac atctgtttga acaccaaaat 1078081 cttcatttaa tttagtcatg atatctgccc tatcttctgt tcttacctta ataggaaaca 1078141 gatgccatac atgatcttca cttaattctg gtaattcaat atagccttta ttctgcaact 1078201 ctgctaattg ggtaatgtat ctatccgcca agaacaatct tttgaagttg tttaatgaaa 1078261 ggtacttcat tctctctaaa ccaattgctg cctgtaaatt gtccattttt gaattaaatc 1078321 caaaattgat gactttctta ttttttacat ttacttcaaa accgtgataa ctaaattgaa 1078381 tgcatttttt agcgagttct tcattatcag ttgctattgc cccagccttg ccacatacac 1078441 caaaattctt atagggatta aaacttaatg tagtgatgtc tgcatacttt cctaagtctg 1078501 tcagtccaat tccttggcag gcatcttcaa ttacttttaa tttataacga tttgcgattt 1078561 gacggatatg ctgcatgtct gaatgttttc cgtataaatg cacaggtaga ataaactttg 1078621 tataaggagt tattgcttct tcaattttgt caggatcgat gcagaatgtt tgtgggttaa 1078681 tatctacata gataggaacg cctcccgaag ctaacacagc attttcagta gctgaaaagc 1078741 tattagccgg catgataact tcatcccctg ggtttaaccc taaagccaat aaacctatca 1078801 taatagcatc ggttccactg ctggttgcaa ttacatacct tttatgtaaa tatgtagata 1078861 aaactttttc gaattgctct aaatagggac cactcgtaaa ttttccagtt ggcaaaactt 1078921 cagttaatgt atttaagata tcttccactt catcattggt tattaatctg tctacaggca 1078981 aaaaagggac tttactgatt tcacgatttt tttgatagtt gaaaaggtca tgttcaatat 1079041 ctatcttttc ttttaatact tgtttccacc gctcgtttac aatactgtct tcaataacaa 1079101 gttcttttcc ttgtacgtca ccttttaagt gttttaatag tgacatgttt tctttgcttt 1079161 tacctgaaat cttaacctgt ttttgcatga acagtacctc caatgatttt ataatctaaa 1079221 aatttattac aaatttatcc tagtttctga aatcggtaac atgtcaacaa cttttttaag 1079281 gaagggaaaa tatgcctaca attgatgaaa tagcaaaatt atgcaatgtg tctaaaacca 1079341 cagtgtcaag agtattgaat aatcatcctt atgtgtcgaa agaaaaaaga gatatgatct 1079401 taaaggctat taacgaactt gactacactc ccaattattt agctcggaat tttaggagaa 1079461 ataagacaca aacgatagct ttatcggttc cgagtatcga ccatccattt tttgctcaat 1079521 taataaaagg ggtctctcat gaagtactgt ttaagaatta caaggtaatt gtatttcaga 1079581 ccttttatga caaacagacg gagctagaat tactagagtt attgaagcat aaagaagtgg 1079641 atggcattat tcttgggact ttagaaaatg aatgggatca gatatcccct ttcttaaagt 1079701 atggtcctat cttattatgt aatgaatatc atcactcagc ggacatcacg ataattgggt 1079761 atgatgaatt tgaagccgca tacatggggg tagtacattt aattgaaaga gggcataaaa 1079821 aaattgggtt ttgttttgat actccatata gcgaagctca atgtcagagg aaagagggtt 1079881 atttgaaagc tttacaagat tacaatttac atcatagaag cgaatggata ttcggcgaaa 1079941 tgtttaatat cgaggatggc tttcgtgttt ttcataagat aaaggatcta aaggacagac 1080001 cctcagcaat atttacagga aatgatcaag tcgccgcagg gattattaaa caggcgatga 1080061 aaaatggctt taaagttcca gaagacttag ctgtaattgg ttttgacaac caattgattt 1080121 gccaagtcgt tactccgacc ataacaacaa ttgatatccc cgtaatagaa ttaggccaac 1080181 aggctgtgtt gaaaatcatc gagtccattt cgggtaatgc ctctttaaac agaagaatta 1080241 ttaaactgcc aacaaagctt attataagag aatcaacgta acgatagatt tccctttaac 1080301 attttatatc tttatataag aaaaagaggt tattcatttt aacctctttt tcaatcgtaa 1080361 gtcgtcaatt atttctttca tttcaccctc tggcagcact cacttcaaat ctgatccatt 1080421 aacaacgaaa tatccgctta tatttcctca tctcgatggt ttgcgaatta aaagttcttg 1080481 aacccttttt tcaactaggc actactgccg ctgattgagc tctttttgtc ttttttttca 1080541 ccatgaagat ggtgaagcag gcgataaaac ggcggcagca gggcaataac cagaatgacg 1080601 cgaatgacct gaaccgcaac gacaaaggtg gaatcagcat gtaaggtaac tgacgtcgtc 1080661 gccatctctg caatcccgcc gggcgcaaat gccagaacag aagtgatgag cgaaattcct 1080721 gtcagctcgg aaacgatcac ggcgctcaaa aacattgctg cgattaaacc gacggacgag 1080781 acaaacccga cgatgataat acgggtgacg ccggcaaaca tgcttttgta catcttagag 1080841 ccgatcgttg ccccgagaaa tacttgtgat acatggttag cttgtgacaa ccaccatgcc 1080901 gtcatgtcgt gccctgtcac cgcagctccg ccaacatgta caattgctac accgagcatg 1080961 ctgccgagca gccatggagc tggaaatttt aaaaatttcg cagctttgca agctccccag 1081021 gcagcgagaa taagaatgac ggtccacaaa acgggagcga gcctaaaatc tgtcgttgca 1081081 gaagaaatcg tctctgctgc ggcacttgcg gtacgatctt gttttgtata gatcagaatg 1081141 actaaaaacg gaatggaaag caccacgagc agcacacgca tcatttgaac gaggctgact 1081201 atagcggtat tggcgcctac ttcctgtgcg atgctcggca tggcggaaag tccgccggga 1081261 gcggtgccga caaagctagt catcatatcc gttttgctga aacgccaaag cacatatcct 1081321 gacagcatgg ccagcaggat agacaatatc agcataacgc cgactgaaaa ccaatggtct 1081381 ttgagaacag agagaacgga taaattcagc ttttggccca attcgatgcc gaggatcatc 1081441 tgcccgaggg cgagccatcg tcggttaatt cctttttggt ctggtgccat catcagccat 1081501 gccggccgta tcatggcgag gcagcaggcg acaatcagtg ttccgatcat ccatccaatt 1081561 gatattccgg ttaatgaaag aataaacccc ccggctgcac tgattgcgat aaaccataga 1081621 tctttgagga gattttcgtc tttcttcaat gtaaaaccct tcttcctttt tcacgtaaca 1081681 ctccaattgt tcacgtagtg aatgtattta ttactatagt atatttttgt tgataaagaa 1081741 attatgaatt attttctata agcgattcac ttttcttatg accttgtgtt cgagcttttc 1081801 tattgtgtaa gtcagagata aacccgctgt cagcagacac acggcaagag cgtaaaaaat 1081861 cacttctccg ccaaatgatg tcaggatcag cccgcctgcc agcggtccga ttgagcggga 1081921 tatatcccaa tgcagaccat agacagcata aaaccggccc agcaaatgag gcggcgccaa 1081981 tttcgatatg aaggtctgga tgtgggttag cccgatgctt tcaccaaccg tcatcaccgc 1082041 tgccgtcact aaaagcattg tcagagaggt tgagcatgca aagccggctg ccgcaaggga 1082101 gtagcaaata taagtaatga agaggatcgt tttcattgaa agcttttcgg tccctttgac 1082161 aagaggtact tggagaacac agctgaataa agcttttgct gctgaataga tggtcagcat 1082221 ggacagataa tcagaaaaca tgtttttgct gaacagcctg tatgttgttt ctgtttgtgc 1082281 atataacatg ctgatgggga gagaaagcag caaaagaagc aggacaggcc tgtatattgt 1082341 aaagctcgcg gacattttcg gggtaacagc tgggtgtagc ggctttgtct caggcagttt 1082401 cagtgcagcg atcagaaagt agataaacaa tgctgcagca tctaatgcga atatccacac 1082461 ggggttatga ttgtacagca gcatccccac tagcggtcct gccgtcagac ccgtcgaata 1082521 gatcgcattg atgaccgcaa acacttccga acgtctgctt tccggcgtgc tttcagcgat 1082581 ttgggcgcgg gaagcgggaa tgtacaacga tcttccgatg ccattcatga catagagaat 1082641 agcgaaaaca tacgcatgct cagcaaatac aaaccctgtc attgccgctg attgaagaag 1082701 caatgcggtc aaaatcgctg tgcgccgccc aagccgatcc gtcacccgtc ctgcagcgag 1082761 cgtcaggaaa atatcagcaa atggctgaag gctgatgatc agcattggca tcatgatact 1082821 gccgtttaat tgttcatgca gatacagcac cataaaaggt cccatcattg cacctgtcag 1082881 gcttgtcagc aattcgccga aaaagcggag ccgaacggga gcggtatatc tcgattttat 1082941 agagtgaaaa ctggtcaaca tgtgatcgcc gcctttcgct gtttgatata gtagtagtgt 1083001 atagaagggg cggcggccca aaaagtgaag aaaagaagag ataaaagttc cccttttgtc 1083061 gggaggtgcg gggattgaag ctgatagagc actacgtggc gcttgtaaaa acaggctgcg 1083121 ccgagtatgg gcaaatgaac gaaatgacgc tcactgagat tgccgactgt ttattttgta 1083181 cagaaagaaa tgcaaagctc attttacata agctggagaa cagcaattgg attatccggg 1083241 aaagcggggc ggggcgcggc cgcaaatcta aaatcgcgtt tcttcggagg cctgaggaac 1083301 tgcttcttca aactgcaaag gaatatacca tgtcaggaaa gcttaaaaag gcaaaggagc 1083361 tgcttcagca gtatcagtcc gcgtttccag ggcttcaaaa cgaatataac atgtggctat 1083421 cagaggtatt cggatttgtg acggagacag gcgagaatgg ggcgaaggat gtcctgcggc 1083481 tgttcatcac gcctgaatct gtcagcagtt tggatccatg ccaaatattt ttgcggtctg 1083541 agggccattt cgtcaaacag atatttgata cactcttcac gtttgattcg gatatgcagg 1083601 agccgaagcc tcatttggtt catggatggg aagaggtcgg aaaaaaacaa tggagatttt 1083661 ttcttcgaaa aggtgtgtta tttcataatg gacagccgct gacatcgcgg gacgttgcgt 1083721 ttacatttca gcgctttttg gaactggctg acaacccgta taaatggctt ctgcacggag 1083781 tgaaacaagt cttagaaaag ggcccttatt gtgtggagct catactcgat aagccgaatg 1083841 cgcttttgcc gtatgctctt tgtgatgaac ggctgtccat actgccggca gaacagggcg 1083901 gcgggaaaaa tggaacaggg ccttttcaga tgaatcagca acatagcggg atgcttgtgc 1083961 ttgaagccaa tgagcgctac ttcaagggac gcccctattt ggatcgcgtt gagtttgtgt 1084021 tttctgagca agccggagag atgaacggtt ttaccattca agaaaaacaa acatgtcctg 1084081 agcagcaaac tgtctttgat gagcggcatg ttcagtattt gtcgcttaat ctgaaaaaga 1084141 aggggcctct tcagcaccga agctttagaa aagcgctccg gctgctgatt tcctctgaac 1084201 ggctcgttcg tgaagcggga gggcaccgaa gaattccggt tacgtccttt ttgcatccga 1084261 gtccttttga gtgggagggc gtttcgccat ctgaattgtt gaaaaaaagc ggatacgagg 1084321 gcgaaacaat cgtgctttat accttttcgg aaacggatca tcgtgaggac gccgaatgga 1084381 ttcaaaatat ttgcgcccag cacggtatca ggcttacact tcaattctgt gatgctgctg 1084441 atctgcgacg gccggaaatc gtgcagatgg cggatatcat tcatgacagt gcgacgtttt 1084501 atcaagacag cgagtttggt tttctgcatt tgctgctgtc ggagaacagt ttcttgtatc 1084561 agcatctatc tgaaaagctg acacagattt gctcaggaat gacagagcgg atgttttcca 1084621 tgcctgaccg ctgttcgaga atcaacatcc tgcgtgacat tgaccggcag atgatacagg 1084681 agctgaacgc gatcccgctg tatcaaaatg tgctccaggt gacatcaagt aaaaatgtaa 1084741 aaggcctggt gcttgatgaa gagggatgga ttgatttgta ctccgtatgg ctgtccaaat 1084801 aaaaagaggg ttcttttttg aaccctcttt tttacgctgc catgctgcgg cattgttcag 1084861 cacaggtgaa gcaggctttc gcacatgctt ggcaatgatc atgatcgtgc tttccgcatt 1084921 cagtgccgca tgcttcacaa atatcggcgc aaagtgcaca aatttctttc ataaacgggc 1084981 tgtccgtttg catggctttg accgccagcg cgcaaatatc cgcgcattcc ctgtcaagcc 1085041 ggatgcatcc gctgagatga tgctgcacgc tttcttccaa gcatttagtg aaacaatgat 1085101 tgcaagcctt catgcaatcg atgcaagcct caatacaagc ctcagaatat tgctccatgg 1085161 ttgattcccc ctgtatgaca gtatatggtt ttatgtttca cggctgcatt tgaaaaaaac 1085221 aggggagtgt gtttttagct aaggggatat gtacatatac cctgaatggg tatatctaac 1085281 gttccatcag atagtatagg aaccagacag cgtgattttg ttcatcacgt gctgcgcgcg 1085341 taaagacgcc tttcgctttt aagtttgacg tttcctcggc cgcacgcaag taaaagtcga 1085401 cggtttcttg ttcatcttta aaagcggcgt ccagtcctct tgtgaaattg tccgggcatt 1085461 cttccgtttg tttcggcatg atgtgtttgc cggtaattga accatacagt gtggaaaatt 1085521 cacggaggtg gcgaatctcg tcacgcctga tttcttcaat ctgttttctg acctcatcgc 1085581 tgtgggcgag ttcggcaagc ttgcggtagc attgaatagc actgaattct ccgttgatgg 1085641 ccttctgcaa attccgaatc aaaacaggat cttcccggta tggcaccgga tagggatagt 1085701 agctgtaatg caaggggatt caactccatt cttaggaatt gggcttctgt aaaagtatat 1085761 gttgggcagg gagagatgtg cggagataat cagcttttta tatgtgaaaa ggccgttttt 1085821 accaatagat cagattggtc attttcgtca acattcgata aaatatagag agataaaaag 1085881 agaggggtct tctaatttgg gagcagagtt tttagtaggc aggtccggga gtggaaaaac 1085941 gaagctgatc atcaacagca ttcaggatga attgcgccgg gctccattcg ggaagccgat 1086001 catttttcta gtcccggatc aaatgacgtt tttaatggaa tacgagcttg ctaaaacgcc 1086061 agatatgggc gggatgatac gcgctcaagt gttcagtttt tcacgattgg cctggcgcgt 1086121 cctccagcat acgggaggaa tgagcaggcc gtttctgacg agcaccggcg tacaaatgct 1086181 cctgcggaag ctcattgagg agcataaaca ggagttcaaa gtctatcaaa aagcgagtga 1086241 caaaagcggg tttaccgcac aggttgagcg gatgctgaca gagtttaagc gctattgtct 1086301 ggaaccggag gatatccgcc ggatggcgga aagcggaacg gcttccgagt atcgcggaga 1086361 acgtgtttta tctgaaaagc tccatgactt atcaattctg tatcagcaaa tggaaaaaag 1086421 cctcgcagat caatatcttc actctgagga ttatttgaca ttgctggcag agcatatccc 1086481 gcttgcggaa gatataaaag gcgcccatat ctatgtggat ggcttttatc agtttacccc 1086541 gcaggaattc agggtgttgg agcagcttat ggttcatgcg gagcatatca cgttttcgct 1086601 cacagcggac aagccgtcat atgagcggga gccgcatgaa ctggaattgt tcagaatgac 1086661 ggggaaaacc tattaccgcc tgcatcagaa ggcgaaggaa ctgaatttgg acattacgta 1086721 taaagagctg agcgggactg agcggcatac aaagacgccg gaattggcgc atctagaggc 1086781 acagtatgaa gcgcgtccgg ccattccata cgcagaaaaa caagaagccc ttactgtgat 1086841 gcaggccgca aacagacgag ctgagctgga aggcattgct cgggaaattc acgccctagt 1086901 cagagagaag ggatatcgct ataaggatgt agcaattctt gcgcgccagc cggaagacta 1086961 caaggatatg gtgaaggaag ttttcgcaga ttacgagatt ccttatttca ttgacggaaa 1087021 agcatctatg ctgaaccatc cgttaattga atttatccgg tcgagccttg atgttctgaa 1087081 agggaattgg cgttatgaag cggtgtttcg ctgcgtgaaa accgaactgc tattcccgct 1087141 caatgaaccg aaggccaaag tgagagaaca ggtcgatcag ctcgaaaatt actgtatcgc 1087201 ctatggtatt aaaggcgacc gctggacaaa gggcgatcgg ttccaataca ggcgttttgt 1087261 gtcattggat gatgattttg cgcagactga tcaggaaatc gaaatggaaa acatgttgaa 1087321 tgacacccgc gattggattg ttccgccgct ttttcagctt caaaaacgca tgaaaaaagc 1087381 gaagacggtt caagagaagg cggaggcgct ctatcgttat ttagaagaga cggatgtgcc 1087441 gctgaagctg gatcaggaaa ggcagcgtgc tgaggatgac ggcagaatca ttgaagcgca 1087501 gcagcatcag caggcgtggg acgcagtcat tcagctgctt gaggagtttg ttgaaatgat 1087561 gggagatgat gagatttctc ttgatttgtt tcagcaaatg atagaagccg gcgcggagtc 1087621 gcttacattt tctctaattc cgcctgcgct tgaccaggtg tttgtcggca atatggattt 1087681 gtccagaatg tatggcacct cctgcacctt tgtgctcggg gcaaacgacg gcgttctgcc 1087741 ggcacgccct gatgaaaacg gggtcctgtc ggatgatgac cgggaatggc tgaaaacgat 1087801 tggggttgag ctatcctcag gcggacgaga gcgtttgctt gatgagcact tcctcatcta 1087861 catggcgttt tcaagtccgt ctgaccggct ttacgtatcg tatccgattg ctgatgcgga 1087921 aggaaaaacg cttttgccgt cgatgatcgt taagcggctg gaagaactgt ttccgcatca 1087981 taaggagcgc ctgttaacaa atgaacctga acaggtcagc gatgaggaac agctgatgta 1088041 tgttgtgaat aaaagcgtgg cacagtcctt taccgcgagc cagctcaggt tatggactcg 1088101 ggaatacgac atcagcgacg tctggtggag cacgtacaat gtgctgatga gtgagcagga 1088161 caggctgcaa tcgaaaaagc tgttctcaag cctgtttttc cggaatgaag tgaagcagct 1088221 tgaacgcagc gtgtcgagac agctctatgg tgaacgtatt cagggcagtg tatcgagaat 1088281 ggaaaccttt aacgcatgcc cgttttccca ttttgcgtca cacgggctgc atttgaagga 1088341 acggcaattc ttcaagcttg aagcaccgga tatcggccag ctgtttcatt ccagcttaaa 1088401 gctgatttcg gacaggctgc gtgagcaaaa gctggattgg cgcgatttaa cgaaggagca 1088461 gtgcgagctg ttttcctatg atgcggtaga gcggctggca ccgaaactgc aaaaggaaat 1088521 tctgctcagc tcaaaccggc attattatgt gaaggaaaaa ctgcaaaaaa ttgtgacacg 1088581 tgtgtccggc attttaagcg agcatgcgaa agcgagcgga ttcgtaccga tcgggcttga 1088641 actgggcttt ggaggaaaag ggccgcttcc gccgctgacc tttcaactga aaaacggctg 1088701 tacgatggaa ctcgtcgggc gaattgaccg tgttgataag gctgaaagct caaaaggcct 1088761 gctcctcagg attgtcgatt ataaatcaag cgacaaaggc cttgacttag cggaagtata 1088821 ttacggattg gcactgcaaa tgctgacgta ccttgattta tcgattacac attcagctga 1088881 ctggctcggg atgagggcga cgcctgccgg agtgctgtat ttccatattc atgacccgat 1088941 gattcaatct aatctcccgc ttgggcttga cgagattgaa caggagatct ttaagaaatt 1089001 taaaatgaag ggcttgctcc tcggtgatca ggaagtggtt cgcctcatgg atacaaccct 1089061 tcaagaggga cgttcaaata tcataaacgc cggcttgaaa aaagacggct ctctcagatc 1089121 agactcagca gcagtcggtg aaaaggaatt tgatcttttg acaaagcatg tgcgccgcac 1089181 cttccaagaa gcgggcgaac aaatcaccga cgggcgcgta tccattgagc cgtacaaaat 1089241 gaagaacaag acgccgtgca catactgtgc gttcaaatca gtatgccaat ttgatgaatc 1089301 actggaagaa aacgagtatc gcccattaaa ggctgaaaag gacaagacaa tacttgagtg 1089361 gataaaaaag gaggcggatg gcaatgaaca ttcctaaacc ggcagacagc acatggacag 1089421 atgaccaatg gaatgccatt gtttcaaccg gccaggatat tcttgtggca gcggctgcgg 1089481 gctctggtaa aaccgctgtg ctcgttgaac gaatgattcg gaaaatcacc gcggaggaaa 1089541 acccaataga tgtagaccgt cttctcgttg tgacatttac aaacgcctca gcggcagaga 1089601 tgaagcaccg aatcgcagaa gccttggaaa aagagcttgt acagcgcccc ggctcgctgc 1089661 atattagacg ccagctgtct cttttaaacc gggccagcat ttcgacgctc cattcctttt 1089721 gcctgcaagt gctgaagaaa tattactact tgatcgatct tgatccgggc tttcggatag 1089781 ctgatcagac ggaaggcgag ctgatcgggg atgaagtgct tgacgagctg tttgaagacg 1089841 aatacgcaaa gggcgaaaag gcgttttttg agcttgttga ccgctatacg acagaccggc 1089901 atgatctgga tctgcaattt ctcgttaaac aggtgtacga gtattcccga tcccatccca 1089961 acccggaggc gtggctggaa agctttgttc atttgtatga tgtatcagaa aagagcgcca 1090021 tcgaggagct gccgttttat caatatgtca aagaagatat tgcaatggtg cttaacgggg 1090081 cgaaggaaaa gctcttgcgc gcgcttgagc tgacgaaagc gccgggcggc ccggcgccgc 1090141 gtgctgacaa ttttcttgat gatcttgctc agattgatga actgattcag catcaggacg 1090201 atttcagtga actatataag cgggtgcccg ccgtctcttt taagcgtgcc aaagcagtaa 1090261 aaggggatga gttcgatcca gcgctccttg atgaggcgac agatttgagg aacggcgcaa 1090321 aaaaactgct tgaaaagctc aaaaccgact acttcacgcg aagtcctgaa cagcacttga 1090381 aaagcctagc cgagatgaag cctgtcattg aaacgctcgt acagcttgtc atcagctatg 1090441 gaaaacgatt cgaagctgcg aaacaggaaa aatcaatcat cgatttttcg gatttggagc 1090501 attactgttt agcgattttg acagctgaga atgacaaagg tgaacgtgag ccgagcgagg 1090561 ctgcaaggtt ttatcaggaa cagtttcatg aggtgctcgt tgacgaatat caggatacca 1090621 acctcgtgca ggaatcgatt ctgcagctcg tcacaagcgg tccggaggag actggtaacc 1090681 tgtttatggt aggagatgtc aaacagtcga tttatcgatt caggcttgcg gagccgcttc 1090741 ttttcctctc taaatacaaa cggtttacag agagcggaga aggcacgggg cggaaaatcg 1090801 atttaaataa aaatttccga agccgggctg atattttaga cagcacaaac tttttattta 1090861 aacagctgat gggcggcaaa atcggtgagg tcgattatga cgagcaggct gagctgaagc 1090921 ttggtgcagc gtatccggac aatgacgaga cggaaacaga gctgctgctg atcgacaacg 1090981 cagaagatac ggatgcaagc gaggaagcag aagagcttga aacggtgcag tttgaggcaa 1091041 aagccatcgc taaggaaatt cgtaagctga tttcatcgcc gtttaaggtg tatgacggaa 1091101 aaaagaaaac acatcgcaat attcaatacc gagatatcgt gattttgctc cgttcgatgc 1091161 cgtgggctcc gcaaatcatg gaggagctga gagcacaggg cataccggtt tacgccaatt 1091221 taacgtcagg ctattttgaa gcggtcgaag tcgccgtcgc gctttctgtg ctgaaggtga 1091281 ttgataatcc gtatcaggat ataccgcttg cctctgtgct gcgctcaccg attgtcggag 1091341 cagatgaaaa cgagctgtct ttgatccggc ttgaaaataa aaaagcgccg tactatgagg 1091401 cgatgaaaga ctacctggct gctggtgacc ggagcgatga gctttatcaa aagttaaata 1091461 cgttttacgg acatctgcaa aaatggcgcg cgttttcgaa aaaccactca gtatctgagc 1091521 tgatttggga agtgtaccgc gacaccaaat atatggatta tgtcggcggc atgccgggcg 1091581 gaaaacagcg ccaggccaat ttgcgtgttc tttatgacag ggcgcgtcaa tatgaatcaa 1091641 cggcatttcg cggcttgttc cgtttcctgc ggtttatcga acgcatgcag gagcggggcg 1091701 atgatcttgg tacggcgaga gcgctcagcg agcaggagga tgttgtccgc ttaatgacga 1091761 tccacagcag caaagggctc gaatttccag tcgtgtttgt agcaggtctc ggccggaatt 1091821 tcaacatgat ggatttgaac aaatcgtacc tgctggataa ggagctcgga tttggcacga 1091881 agtatattca tccgcaatta cgcatcagct atccgacact tccgctcatt gcgatgaaga 1091941 aaaaaatgcg cagggagctg ctgtcagagg aattgcgtgt gctctatgtt gcattaacga 1092001 gagcgaagga aaagctgttt ctgattggct catgtaagga tcatcagaaa cagcttgcaa 1092061 aatggcaggc atccgcgtcc caaactgatt ggcttctgcc ggaatttgac cgctatcagg 1092121 cgagaacgta tctagatttc attgggccgg ctcttgccag gcacagagac ttgggggatt 1092181 tggctggtgt gccagcacac gctgacatct caggtcaccc ggctcgtttt gccgttcaaa 1092241 tgatccattc ctatgatttg cttgatgatg atctggaaga aagaatggaa gaaaaaagcg 1092301 agcgcctaga agcgatccgc cgaggtgaac cagttcccgg ctcgtttgcg tttgatgaaa 1092361 aagcccgcga gcagctgagc tggacctacc cgcatcaaga agtgacgcaa attcggacaa 1092421 agcaatcagt ttctgagatc aagagaaaaa gagagtacga ggatgaatac agcggcaggg 1092481 cccctgtaaa accggctgat ggaagcattc tgtacagacg tcccgctttt atgatgaaaa 1092541 aaggcctgac agcggcagag aaagggactg ccatgcatac ggttatgcag catatcccgc 1092601 tgtcacatgt gccgtcgata gaagaagctg agcagacggt tcacaggctt tatgaaaaag 1092661 agcttctcac tgaagaacaa aaagacgcta ttgatataga agaaatcgtg caatttttcc 1092721 atacagaaat cggcggacag ctgatcggtg ctaagtggaa ggaccgggaa ataccattca 1092781 gcttagcgct tccggccaag gagatctatc ctgatgcaca cgaggcagat gagccgcttt 1092841 tagtgcaggg tattattgac tgtctctatg aaactgagga cggattatat ctattggatt 1092901 ataagtcgga ccggattgag ggcaaattcc agcatggatt tgaaggagcg gccccgatct 1092961 tgaagaaacg atatgaaacg caaattcagc tgtacacgaa ggcagtggag caaattgcaa 1093021 aaacaaaggt aaagggatgt gcgctttatt tctttgacgg agggcacatt ctgacattat 1093081 agcgagatcc ataagctccg gaatttcagg cggagcgggt ctcgttttct atataaaaga 1093141 gaggtgaaag catttgcgga ttttacatac ggctgactgg catcttggaa aaacgcttga 1093201 aggaagaagc aggctgagtg aacaggccga tgtgctggat gaactgaata cgattgtaaa 1093261 ggatgagcag atcgatgcca ttgtaatggc gggggatgca tttgacaccg taaacccgcc 1093321 agctttagcc gagcagctgt tttatgaaag cctgtctgcg cttagcgaca gaggaaagcg 1093381 cccgatcgtc gtcattgccg gaaatcacga taatcctgac cgtttgtccg ccgcttcacc 1093441 gctgacacat gaaaacggca ttcatttaat cggttatccg acaacagagc cgattcatat 1093501 tgaagtgcct tcagcaggag agcttttggc ggttggagcg ctggcgtacc catctgaagc 1093561 gcggttaaat gaagtgctat ccgatacgtt tgatgaaaag ctgctccgtg atcactatga 1093621 tgtgaaaatc aggcaggcgt ttgagcatat gacaagccgg ttccggaccg atgcagtgaa 1093681 gattgccgcc agccatattt atgtggcagg cggaaaccaa accgattcag agcggccgat 1093741 tgaagtcggc ggtgcataca cggtggctgc tgaaagcctg ccggcagatg ccgcttacgt 1093801 tgcgctcggc catttgcatc gcccgcaaac gatcaagcgg gcgcggacgc ttgcgcgtta 1093861 ttcaggatct ccgctcgcct acagcttttc tgaagcgggc tacgctaaat cagtgacgat 1093921 tgtggacgca aagcctgggg aagaggccac ttggcaagag gtgttattat caagcggcaa 1093981 gccacttgtg aagtggaaag cggcaaatgg attaagtgag gtgtacagct ggctggatga 1094041 aggcagagat cagaatgctt ggattgactt ggaaatccgt gtcgcggacc agctgtcact 1094101 tgaagagatt cacaggctgc ggaaggcgca cccgggcttt atccatatca ggccggtttt 1094161 tgaagaacag aacaaagacc gggaacggat cgaggttaaa catgtctcaa tcgaggaccg 1094221 ctttaagaaa ttttatgaaa aacaaactgg cggtgcggtg ccggatgaag aaatggtgaa 1094281 gctgttttta gagcttgcat caggcgttga agaggaggat gcgaaatgaa gccgatcgcc 1094341 ttaagcatta aggggctcca cagctttaga gaggagcaga cgatagattt tgaaggcctt 1094401 tccggtgccg gtgttttcgg cattttcggc ccgacaggaa gcggtaaatc ctctatactc 1094461 gacgcaatga cgcttgcttt atacggaaag gtggaacggg cggcgaataa tacgcacgga 1094521 atcttaaatc acgccgaaga tacgctgtct gtgtccttta cctttgcgct tcagacgaat 1094581 caccaaatct catacaaagt cgagcgtgtg tttaagagaa cggatgaaat gaaggtaaaa 1094641 acggcacttt gccgcttcat cgaaatcaag gacgagcata cggtgctggc tgataaagcc 1094701 agcgaagtga ataaaagagt ggaggagctc ttagggctga cgatcgacga ttttacgaga 1094761 gcggtggtgc tgccccaagg gaaatttgct gaatttctgt ctttaaaagg ggcagagcgc 1094821 aggcatatgc ttcagcgttt atttaatttg gagcaatatg gagacaggct tgtgaaaaag 1094881 ctgagacggc aggcgcagga agccaatgcg agaaaaaatg aaatgcttgc tgaacagtcc 1094941 ggtctcggtg aggcgagctc agaggcagtg gagcaggctg aaaaggttct cgaacaagct 1095001 gaagcccggc tggaagcgat gaggaagaac cgtgatcagg cgaaggagcg gtttacagag 1095061 catcaggaga tatggaatgt ccaaaaggaa aaatccactt atgaagaaga ggaaaaacgt 1095121 ctcgcagaag aacagccgca tatagacagc atgcaaaaac gcctgctgga agcagaaaca 1095181 gcagcagccc ttaagcccta tgcggaccgg tacgcagaag cgatccagca tgaggagcaa 1095241 gctgaaaagg aacaaacgct agcccaaaag gatttagcag accggacagc tttctttcag 1095301 caaaaacatg aagagtatga agcgtggcgc cagcataaaa gcgagaaaga gcctgagctt 1095361 ttagccaaac aggaacagct ttcacgcttg caggaaatcg aaatcaaact gagtgaggcc 1095421 aagcaagagg aagagcgcaa aaaggctgac ctccggcaga aagaagaggc tcttcaatct 1095481 gtcatgaatg aattagagac cgtaacagac cgcctgacac gagggcaaaa cagacagaca 1095541 gaattgaagc agcagctcaa atccctgcag gtgacatccg atgagcgaaa aagctgccag 1095601 caggccgcag agatggcatt gcgcatcaga caaaccgagg aacaaatcaa aaaagagaaa 1095661 aaacgaagtg aagaattgaa cctcgtgctg cagaagatga atgaagagaa gaatacactc 1095721 gttcaaaaga cggaagcgga agaaaacaac atcattcagg catatgaggc agttcaaact 1095781 gtgtaccatt tggtgtgcga aacggaacgc tcattaacac gtatgacgga agaggctaga 1095841 aagagtcaac acacgcttca cttacagcgt gaaaaagcaa gggtggcact gctgacaaaa 1095901 gagttagccc aaaagctgac tgccggaaag ccttgcccgg tatgcggttc aaccgatcat 1095961 gatccatctg cctcggtaca tgaaacgtat gaagccgaca gccatcttga agaggacatc 1096021 aaacggacag atgtgttatt gacggaagct gcagctctca gccaggagat tctttcagcc 1096081 aaaattatgc ttgaagaaca gtccgcgcgc tttattgaac agtgtccgtt tttgcagaca 1096141 attcaagcac agaaccttga agcggcagct tccttcgaac atcagccggt gtatgaagca 1096201 tttgaaactg ccaaatttga atggaaacga atcaagcagg acattctttc tgttaagaca 1096261 cgaatggcac aaatgattgg cgcctatcag gagtctttaa aaaaggccga gcagcttaat 1096321 gaaaaaatcg gttttgaaaa aagagaagcc gaccgtattg aaagcatcat cagtgagctt 1096381 caatcctcaa tggacagcag tctgaacatg tttaaagaag catttcagaa tcaatctgtg 1096441 gacgaagcag aaaaatggca gcaagccatt gaagaaaagg accgggctgc agaagaatgt 1096501 gaaaaacgaa ttgagaagag tatcgcgttt cttgctgagc atgaagcaca aaaggaaaaa 1096561 ctgcgggaat cgggacaccg gcttgagcgg gaaaagctgg agcttcatta tgcggctgaa 1096621 cgcatcaaga gcgtgatagc tgattatgag cacgaactcg gagattatgc aaaaggagat 1096681 tcgattcaaa tcaaactccg ctctgtccag caggatctaa agctgttaaa ggaaaaagaa 1096741 caatctttat atgaagaact gcaaagcgcc caaatgaagc tcaaccaagc gaaaagccgc 1096801 gcttctgcaa gcgagctcac tcttcaagag gcgaagggca gattggaaaa agcaaaagct 1096861 gcttggcttg agcatacaaa aaacacctcc attacccgga ctgaggaggt tgaacaaagt 1096921 ctcatcccag ctgatgaact tgaaaagatg aaaaccggca tagaccagtt tatggataaa 1096981 ctgaagcaaa atgctgcaaa cttaaaacga gtagcagaga tacttgccgg cagagcatta 1097041 tcagagagcg aatggaacga aaccgttgca gcattacaag aagctgagga cgcatttggc 1097101 gctgctatag aggaaaaagg cgcggccgca aaagcactgg ctgtcattcg cgaccatcat 1097161 aaacggttta atgaaattga agctgaactg aaaaaatggc agatgcatat cgacaggctg 1097221 gacaagctgc aagctgtgtt taaaggcaat accttcgtcg aatttttagc tgaggagcag 1097281 cttgaaagcg ttgcgaggga cgcctcagca agactcagta tgctgacaag acagcgctat 1097341 gccatcgaag tagattctga gggcggcttc gtgatgcggg atgacgcgaa tggaggcgta 1097401 cgacgcccgg tttccagttt gtctggagga gagaccttcc tcacctcgct ttcacttgct 1097461 cttgcgctgt ctgcgcagat tcagcttcgg ggggaatacc cgctgcagtt ctttttctta 1097521 gatgaaggct tcggcacact ggatcaagat ctgcttgata cggttgtaac ggccttggaa 1097581 aaacttcagt cagacaacct ggctgtcggt gtcatcagcc atgtgcagga actgcgtgca 1097641 cggcttccga aaaagctgat cgtccatccg gctgaaccga gcggccgcgg tacgcgggta 1097701 tcacttgagt tgatgtaagg gaggagcgga tatggcaaag cagattgccg gaatatgtga 1097761 gctgtgcggc cggagcgatg tccagctgac agagcatcat cttacaccga aagaggaagg 1097821 cggaacgttt ttgccgacag cgatgctctg tattccttgt cataaacaga ttcatgcctt 1097881 atataccaat caagagctcg ctgtacgttt aaatggaatg gctgaactca gaagcgatcc 1097941 agagcttgcc cggtttgtca aatggatcag aaaacagccg cctgagaagc tgatcaaaac 1098001 taagaaatca aatgaacgaa aaaagaaaaa atgactaaaa agcagccctc tctttgcaga 1098061 gcggctgctt ttatccgttt ccaaccatat cctgatcgtt gacatcgggg tctatataat 1098121 ttgtcgcgtt gactgcatta tttaatagaa ggaaatctcc cgtgtttcct gctcccgaac 1098181 cgagcgcaga ttttgaagag cttttcggag aaaggtaaaa ggaatcacca aagtttacga 1098241 ctccgcccga tatggaattg atagctatag gcccgacaat tgctggcata aacgacaccc 1098301 tttatcgaag tctctgttta ttatatgttc ttggcgggcg attgtgagcg cggagactga 1098361 atctgtctga tatgtttgag tctcgcatca ccgcgaataa gcgaagctga tccggcatgt 1098421 aaaacagaag aggctgagac cccttgaatt ttgatgctgc gaacataaat agccggcacc 1098481 tcgtggcaaa acgcgctttg tacacctgtt tcggggagcg gcttcacggc ctgctgctga 1098541 aagatctgat actccttttt gttaaatgag ccttcattat ggtaaaacgt ggacagagaa 1098601 cgctgcacag caaatacttt tacactcata tcgatttcat ttgtgtcgcc aacttgaaac 1098661 acacttgcga tcccgagaga attaaactta actagtctga tgcgcgatat gcgtttaagc 1098721 attattctgg cgcaagcgga gcaaacggcc caataataag agattcaggc ggtgtatcaa 1098781 aaatagaaga caggtagatg gattcagtgt ctccgatgtg gaaaacggag gaactggaca 1098841 caccgttcat ccgaatatcc ccgacttcca agctgcggtt gatgactgta aagatcatgc 1098901 ttgctcatct cctttcattt ctgatggaat atgctccaga aagtgttcta cagcgcggat 1098961 gacatcacgc ttcacatgct cagcgatatg ttctgcatat tgtgcaggcg gtgtattttc 1099021 ttcttttttg atatgggaca tataatagtg aatcctgctg tccatttgtt ttctgatgtc 1099081 ttcaataaca tgatgtctgt ttgtatcgtc aagtctgctg tcatattgat tttcaagctg 1099141 ttccaaaata tctgggattt cctcggttaa gtacatgtcg acattctggc ggatctgctg 1099201 catgagctga gcgctctctt cctgctgcat catcccgatt tgcggtgtcg actggctgac 1099261 gtcaaagttt tggacgctgt tcgggtcagt cggatttaaa ccgatattca aagtcccgtc 1099321 gagcctttcg attttcagct gatcaaattt atactccaca cgctcaatgg tagtggccgg 1099381 ccgctgtttc atcgtattca tttcagtttg aatctctttc agctgacgtt cgagctgctg 1099441 aatgtgaatc gcctgctgct gaacgaagga attcaagttt tgcaggtaag aggaaacaga 1099501 ttgatcatac atgttcttca cctctttcat atgattaacg gccaggaggc tggagcggga 1099561 ccaatgaacc tgtgtcgggc tcctgcagct ggagcggttg ccctgagcca gaaacttctg 1099621 gtgccggctc tacatagctt cctgtattat acaaatttga cagtgacttg attgatccgg 1099681 cgctcccgat ttgcagaatg gaggagttgc tgattgattc cagccggaga tagttgattt 1099741 gaatggtttg attaatatag aagttcatga gcctcactcc ttttacgcat tggccacgat 1099801 cggctgatca accgcatcat tgtcatacac attcgtcgcg ttttgataat tcatcacctt 1099861 gaggctgtcg ccggtattaa agctgccagc accggcaaac gttctgacct gagcctgagg 1099921 agaaatcgta atgcagtccc cgatgtgaac gactccgctc gtaccaatcg cattaatttt 1099981 aaacgctccg acaatggccg gcatacgagc acatcctttg ttgaaaaatt aaaaaaagac 1100041 aggtaaagtg aaatgacaat tccgatttca attgggctat tcacgatagc ttatgacaaa 1100101 cgcacatatg tgtgagagaa attttaaggg gacatatcgg ctctttgtga aagcgtttta 1100161 ttttttcggg ccgttatgtt taaacatggc aaaagaggat gttgggtata aattgagcgg 1100221 aaatgcggcg aaggatgccg ctatccgcct atggtgattt ttgtttattt ctttggtgtt 1100281 tttgcgtgta gaatgctttt tggagtatgt cgtgctgcgg tattcgattt ttgggcgggc 1100341 acattctcgc cctgaggtat atctcagaag tgctgagcaa aaatcggagt taaatgtggt 1100401 gtattctaat tgttatagaa aatgatttac atacgggagt tttcaagata tctcccaaaa 1100461 atcatttctt ctttaatccg ggtattcagc aggatatcca gctcttggct gcattgaatc 1100521 gtttcttttg aattcatgcc gtatttttgt gcggtttcaa ttagtgtgat cctcatttct 1100581 tcaattttac tgttcattac gctatctcca attctagatt ttattttgat ataaatacag 1100641 gatatcgtta gtataaccta ttttggctca aaaggttgcc tttcgtcaat ttgactaaaa 1100701 aagcgacaat ttttgctgcg gcctttttta atggagaaag gactaaagtc ttgctaagtg 1100761 tgcttgcaaa aagtcctgcc gttcctcaat ttctctaagt atgttggtct gctccttttc 1100821 gatttgaaag gggctttttt tgataaaagg atcatcagca gcactttgac aaatgtcaag 1100881 gtgccattcg ttgatgagag gagataatcg ttcaatagta aacgaccgct tcagcacgtt 1100941 tttcattaag gtgtgatatt gcgacctgaa ggcgggaatg gatagaagcc ttgacgaaag 1101001 cgtctttcct tttgtcagaa gcgggtcttc ttcataccat tcttgtacgg caagcgatct 1101061 tgtctccatc ggggaaacgt aaagccgacc ggattcgttt aaacaaaatg tgtagtaaaa 1101121 gccttgattg gtgcaggtgt tgccgatcag ccacaaaaaa aacagcttga catccagata 1101181 caatttaatc ctttcagcca attcgtcatc tccggctgtg cggatcagta tgaaaaattc 1101241 atgtaagaat gccgaggaat cattgttaaa aagggacaat ggaacccttg gatcggccgt 1101301 cttcactccg taactccttt taccggctgg ctgatggttc ttgatgttca aataaatgcc 1101361 ttcaggctgg ccattgatgg tcagaaagct gtacgaggca acgggagcag gtacgccgat 1101421 ctggtcaaaa aaacaatagg cgagtctgcg ccgcatcagg gacggatcat cctgttctgc 1101481 attcaaaaaa agtgtccttt caccaagcag agacttttcc cagctgattt cataggatgc 1101541 cttttccgct ctgtcacgct gtgtgagaag aatgggagaa acagatcgat ctgttacgaa 1101601 aagccccttg gctgtacctt tccttttcag ctgctcccga tgaaaaaata aatgcacgcg 1101661 ctccatattc tttcctcctt ctcaaaacga catttgtatg atatgtagag caagcccgtc 1101721 ctgaaacgaa atgaaaacgg aattgagaaa aagggatttc agcattcgac agagaataca 1101781 tgaaggagca ttctgattta aaagatgatg gaggaataac atgaaatttg cgacagggga 1101841 actttacaac cgaatgtttg tcggcctgat cattgacgat gagaaaatta tggatttgca 1101901 gaaggctgaa aaaaaactgt ttgaacttga gacgattccg ggatcgctga ttgaatgtat 1101961 cgcagaaggg gataaattcg ttgcgcatgc aaggcagctg gccgagtggg caaagaaacc 1102021 gaatgatgag ctgggatcat ttatgtattc attatctgag gtgaagctcc atgcacccat 1102081 tccgaagcca tcaaaaaata tcatctgcat cggcaaaaac taccgggatc acgcgattga 1102141 aatggggagc gaggctgata ttccggagca tccgatggta tttacaaaat cgccggtaac 1102201 ggttacgggg catggtgata tcgtaaagag ccatgaagag gttacctctc agcttgatta 1102261 tgagggagaa cttgctgtcg tgatcggaaa aagcgggact cgcatttcaa aagaagatgc 1102321 atatgaccat gttttcggat atacgattgt gaatgatatc acggcgcgtg atctgcaaaa 1102381 aaggcataag cagtttttta tcggaaaaag cttggatacg acatgtccga tggggcccgt 1102441 gcttgtacat aaatcatcta ttcaggagcc agagcgcctc aaggttgaaa caagagtcaa 1102501 cggcgagctg cgccaatccg gttcggcaag cgatatgatc ttttccattc cggaattaat 1102561 tgaaaccctc tcaaagggga tgacgcttga agcgggcgac attattgcca ccggtacgcc 1102621 gtctggtgtc ggcaaggggt ttacgcctcc aaaattcttg cggtcaggtg acaaaattga 1102681 tattacaatt gatccgatcg gaacgctgtc aaaccaaatt ggctgaataa aactggaggg 1102741 cggacccgga cccgcccgtt ttttctgata atcatctttg tgacagagga caagttcatg 1102801 gtactataag tggggtaatt tatctgatag ggggaacata tatgacacac ctacatatta 1102861 cgacatgggt ggtagcgctg attctgcttt tcgtcagcta ctcgctgtat tcgtcaggaa 1102921 gtgcaaaggg cgcaaaaatc actcatatga ttctgcggtt attctatatc cttattattt 1102981 tgacaggagc tgagctgttt gtccgtttcg ccaactggaa cggagaatac gccggcaaaa 1103041 tgattctggg cattatcacc atcggcctga tggaaatgct cctcatccgc aagaaaaaag 1103101 aaaaatcaac aggaggcctg tgggtcggct tcgtcattgt ccttttgctg acagtgctgc 1103161 tcggtctgca tttgccaatt ggttttcaat tgttttaata gaaaaaccta tgaacccggc 1103221 tctttgatag agctggtttt ttttatattt atcccctcat attccaaatc atttaaaata 1103281 accttaaaat tccctgtaag cggtatctcg tcctatgaaa ttatgatacc ttcaaggaga 1103341 ttcattattt tgcaggaggg ataacatgaa acgcagaaaa ttcagctcgg ttgtggcggc 1103401 agtgcttatt tttgcactga ttttcagcct tttttctccg ggaaccaaag ctgcagcggc 1103461 cggcgcgatc gatcaggcgg ctgctctgga aaacggcaaa gagcagacag gcgccatgaa 1103521 ggagccggaa caggtgaaat ggtacaaagt gaccccggga gcaacggata ttcagaaaaa 1103581 ctcacatatg gcactgaccg taaagagtga ttcagtactg aatgtatctg tatatccaag 1103641 taaggaaaaa gcgcttaaag atgagacgtt tgagatgtac cgttctttca cagcggagga 1103701 tggaaaaagc gaagtcattt ttccatacgc gtggagcggc ccttactatg taaaagttga 1103761 atacctcgga gaagaagaac cagaggacgg cggaacggca gaagcagctg cagaagccaa 1103821 gtatacgatt gggtataaag gcaccaaaaa acagccgtca gatttagaag aggaagaagc 1103881 ttgtccggtt gaaatgagtg tcgatcagaa gaaatcagga aaaggcatcc tggataagtt 1103941 gagatcgatt cgtgatgagc agctgagcca aacagcagaa ggcaaagaac tgacaagcct 1104001 ttattacaaa gcagcaccgt ttatcgttgc aaagctcgca ctcaataaaa cagcaagaaa 1104061 tgaaatctat caggatcttg tgacattaaa gccgttattt gacgatgtgt cagaaaacgg 1104121 agcatcatct tcgtataagg tcactgaaaa ggatcaaaaa gcgatcaacc ggctatatga 1104181 taaagcttta caatcagtcc cgtcattcct taaagaggag ataaagaaac aagcggaccg 1104241 actaaatatg aagcagctgc aaggcaaaac agcaggagcc attttaacag aaaacaatat 1104301 tgcagcaaaa agtgaagttc agacaacaaa ggttattttc aaggtgaagg acaataaaag 1104361 cctctcatcc gtacataatg aaatgaaggg cttttctgca agcgcgcaat cgaaaaaaga 1104421 catatctaat gtgaaaaagg caaagaaact gtttgacaat ctgtattcat ttgaacttcc 1104481 gaaagacgag aaacagaacg gcgcatatac ggcaagcgcc aaaagggtca aaagcgctgc 1104541 tgcgacacta tccaagatgt ccaatgtaga gtttgcggaa cccgtacagg aatacaaaag 1104601 cttggcaaac gatattcagt acccttatca atggccgctt aaaaacaacg gtgaaaacgg 1104661 cggtgtcaaa aatgcggatg tgaaatatga gcctgccaac acattgctgt ccaaacgcaa 1104721 gcttaacgat acactcattg cagtagtaga cacaggcgta gacagcacgc ttgccgattt 1104781 aaaaggaaaa gtaagaacag atctcggaca caattttgtc ggacgaaata acaatgcaat 1104841 ggatgatcag gggcatggga cgcatgtcgc aggcattatt gcagcccaaa gcgataacgg 1104901 ctattcaatg actggattga atgccaaagc aaaaatcatc cctgtaaaag tgcttgattc 1104961 cgcaggttcc ggagatactg aacaaattgc tctcggcatc aaatatgctg ctgacaaagg 1105021 agcaaaggtg attaatttaa gtttaggcgg aggctacagc cgcgtgcttg aatttgcttt 1105081 gaagtacgca gctgacaaaa atgtcttgat tgccgcagcc agcgggaatg atggagaaaa 1105141 tgccttatct tatcctgcat cttctaaata tgtgatgtca gtcggcgcaa cgaatcgcat 1105201 ggatatgacc gctgatttct ctaactatgg aaaaggtctg gacatctctg ctccagggtc 1105261 tgatatcccg agcttagtgc cgaacggaaa tgtcacgtac atgagcggaa cgtctatggc 1105321 gacgccatat gctgccgccg ctgcgggact gctgtttgct caaaatccta agctaaaaag 1105381 aacagaagtt gaggatatgt tgaaaaagac ggcagatgat atttcctttg aaagtgtcga 1105441 tggcggagaa gaagagttgt atgacgatta tggcgatccg attgaaattc cgaagacacc 1105501 tggtgtagac tggcattcag gctacgggcg gctgaatgtc atgaaggctg tcagcgcagc 1105561 tgatttacag cttaaggtca acaagctgga aagcactcaa acagctgtca gaggaagcgc 1105621 gaaggaaggc acccttatcg aggtgatgaa cggcaaaaag aaactcggca gcgccaaagc 1105681 cggaaaagac aatgcgttca aggtgaatat cgcgactcaa aaacaggatc aagtactgta 1105741 tctgaaagca acaaaaggcg atgcgaaaac atcgtataaa gttgttgtcg tcaaaggaaa 1105801 accttccggc acaccgaaag taaacgcggt gaaaacgaag gatacggcag taaaagggaa 1105861 ggcaaacagc aaagcgatga tcagagtgaa aaacaaatca aagaaagtca ttgcttctgc 1105921 caaagctgac gcaaaaggaa cgttttcggt gaaaatcaaa aaacaaaaag ccggaacggt 1105981 gctgtacgtc acggctgtgg atacagataa aaaagaaagc aaggaagcaa aagttgttgt 1106041 tgaaaagtaa ccaaaaagcg gtgctcgatg caccgctttt ttatttgcgc ccccgttgga 1106101 ctgctgtgta cataatggat cgctttccgt ttgaagccgt ccattcaaaa cggtctcctg 1106161 tcccttcgct gctgtagttg tagtgatgct gcatcgcgca ttgtgcggtg tcatttgaaa 1106221 agtgataaaa ggacacaccc tgccccgccg aagtattcga aaagactcct ttattataag 1106281 aaaagacgca atcgaatacc gataagccga agctgtgcaa gtgctgcaga aatgcgagaa 1106341 aggtttcgtc gtcaagcgaa tccaaaagcg ccatgagcgg ccgcttgact gatttctcat 1106401 agcggatgcg ttctccgccg gaaagggaga tgttttctgc accgcatgcc aaaaccaact 1106461 tgtcctgaaa gccggcttgc tcccactttc ctttatgatg gatccagatt gggctgtgtt 1106521 ggagactgtc cgccagcagt atatcgcctt caccgttttc gattaagcag atgccgtctt 1106581 caatgaggat ggtgccgtat tcccactttc gttcctctgt atataacaat tgtttccgtt 1106641 tcatccatgc tgtctccttt ttcttcattc ctctcttttc tttccaattc aagcctgtcc 1106701 catacaactc ttttatggac aaatcaacta tctgcctata gatgcataaa cttactaagg 1106761 tgctgaaaga aacgaaattg ttacgaaaga aacgggattg gagctgatgt cacatgtgtg 1106821 gaattacggg ttgggtcgat tttaaaaagc agctcgtcca ggaaaaacaa acgatggaca 1106881 gaatgacaga cactctttcc aaacgagggc ctgatgattc aaacgtttgg ggggagcacc 1106941 atgttttatt cggacataaa agacttgcgg ttgttgatat tgaaggcgga cgccagccga 1107001 tggcgtgtac ctataaaggc gatacgtaca ccattattta caatggcgag ctttataaca 1107061 cggaagattt gcgcaaagaa ttgcgggcgc ggggccatca attcgagcgt acgtcagata 1107121 ccgaggtgct tctgcacagc tacatcgagt ggcaggaaga ctgtgtcgac catctcaatg 1107181 gcatattcgc tttcgctgtg tgggatgaaa agcgtaatct gttgtttgcc gcgagagacc 1107241 gtctcggtgt aaagccgttt ttttacacga aggaaggctc ttcatttctc ttcgggtcgg 1107301 aaatcaaagc aatcctcgcg caccctgata taaaagcgcg agtggacaga acgggacttt 1107361 ctgaaatttt cggtcttgga ccgtccagaa ccccgggcac tggcatattt aaaggcataa 1107421 aagaaatccg cccggctcac gcgctgacat tttccaaaga cggacttaat atttggcgtt 1107481 attggaatgt tgaaagcgaa aaacatacgg acagttttga tgacacggtt gccaatgtca 1107541 gatcgttatt tcaggacgcg gtgacgcggc agcttgtgtc ggatgtgcct gtttgcacat 1107601 tcctatcagg cggtctggac tcaagcgcga ttacagcgat tgcggcgggc cattttgaaa 1107661 aggaaggaaa agcaccgctt catacttatt cgattgatta cgaagagaac gataaatatt 1107721 ttcaagcaag cgcttttcag ccgaatgatg acggaccatg gattgaaaaa atgacagagg 1107781 ctttcggcac aacgcaccac aaatgcgtca tcagccaaaa agacctcgtt gatcatttgg 1107841 aggaagctgt actggtcaaa gacttgccgg gaatggcaga tgtcgactca tccctgctgt 1107901 ggttttgccg ggaaatcaaa aaggactttg tcgtcagcct atcgggagaa tgcgcggatg 1107961 agattttcgg cgggtacccg tggttccata cggcagatgt tgagtctggc tttccatgga 1108021 tgagatcaac ggaggagcgg atcaagctgc tttctgactc atggcagaaa aaattgaatc 1108081 tgaaagaata cgtaaatgcc aaatatgaag aaaccttggc agaaacgcca ttattagacg 1108141 gagaaacggg tgtggataaa gcaagaagac agctgttcta tttaaatatg ctttggttta 1108201 tgacgaacct tttggatcgg aaggatcgca tgagcatggg ggcgagcctg gaagtgcggg 1108261 tgccgttcgc cgatcaccgg cttgtggaat atgtttggaa tattccgtgg gaaatgaaaa 1108321 tgcatgataa tcgggaaaaa ggcattttgc gcaaagcgct tgagggcatt ttgcctgatg 1108381 acattttgta tcgcaaaaaa agcccatatc cgaaaacaca tcatccggaa tatacaaaag 1108441 gcgtcagcga gtggctgaaa acgatcagaa gccaaaagga ctccgtgctc cataccttac 1108501 tggacagaaa acaattagat cagcttttag aaacggaagg ctcctccttc aaggtcccgt 1108561 ggttcgggca gctcatgaag gggcctcagc tgatcgccca tcttgctcaa attcatacat 1108621 ggtttgaagc gtatcgcatt gatattgacg agaggtaggt tcaatacaaa tgtgattaaa 1108681 agccagagat gtatagattt aaataagaag gatagatgag cagggaaata tatgctctat 1108741 ctatcctttt ttgtacaaca gcactatcga attgcccccg cattccttca ataagaatga 1108801 ataggtttta atgttctgcc gataaaacta gctgataccg ggcttaactt taattcccta 1108861 gcccatacag aaagttgacc aatatggtga atttcgtgag cgatgatatg gtgtaatatt 1108921 tcatctcgcg tatataaaac acctgtctcc caaggaacgc ttacaagttc atcttttatt 1108981 tgatctgaat gtgtttgtaa aacatcaatt atttcagttc ggaatgtatt tgagagagat 1109041 ttcactttat tgagtgtttg ataatcagcg aactgaacag cgatatcttc ttttccttgg 1109101 atagcacgaa tccaactata ttccacatca ataatatgaa aaagggtata taaaatattc 1109161 tctactccgc caagacgatt tttaagtaat tcttcagtgg ttagttgatg acaccaagta 1109221 aaccattgat ctctaacctg ccagttatat tcaaaaaatt tcatcactaa actcactcca 1109281 atactatcat gtatcataac aattagccct tttttccgtg attcctctat taatgaagtg 1109341 atgattgaga aatgtttaca ttctacctgt tgtatggcat taaaaataat aatgcatatc 1109401 tcgtcgatga tgctgtgcgt cttgttactt ttacaaagta agaatcggca ttttcttcat 1109461 atacaattag gaaaaaacat actagacttg aagaagcagt gatacatagg agtgagaaaa 1109521 tgaaagagat aaaagaagct taccagcaat gcggacagat tgttggcgaa tacgcgccag 1109581 cctgtttcaa agcattatca tatctcccgc taaagcaaag acaagcctct tgggcagtat 1109641 tgtcgttttg ccacacggcg gccagtgcag acgaaaaggt attgcccgca tttgaagcta 1109701 aagctgatca tgtttaccaa aggacaaata acggtaaaca acatctatgg aaggcttttg 1109761 atcatgcgta tcggaccttt acattggaaa gcgaaccttt tcgggagttt attgccgcac 1109821 aaaaagaaga cgccaagccg tatgatgacc ttgatgaact gctcatgtac gcatatcgga 1109881 cgggcggtgc tgccggattg atgctgctgc cgatactgac acgccgaaaa caagatcagc 1109941 tcaaacaagc agccgtctct ctcggcttgg ccatacagct ggttcgcttc ttaagtgatc 1110001 ttggcacaga tcagcaaaaa aaccgcattc cccgtcaggt aatgcagcaa ttcggctata 1110061 cagaggctga tctccaaaaa ggcaccgtaa ataaagcgtt cacaatgacg tgggagtata 1110121 tcgcttttga agcagaagcc taccttgaag agtgtcagga tgccttgccg ctatttccgc 1110181 agtattctca aaaaacggtg aaagccgctc ttcatttgca ccgggctgtt ttagaaaaaa 1110241 tccgggcgaa gcagcacgat gtatttcaat atcacttcgc tctcacagag accgaagtga 1110301 agcagattct gtctgatatc taaaaaacac ccggccttga ttgagccggg tgttacgcca 1110361 tacctttttg aatccagata cgtgagcgcc atcttctgta cattaagatt ccccggaccc 1110421 attcatccgc gataaaagaa atccaaatgc cggcaagacc gaaaccgagg tggatgccga 1110481 aaagataagc aagcgggagg ccaatgcccc acattgaaat cattgccatg taaaccggga 1110541 atttcgcatc ccccgcggcc cgcagagagt taatgataat gacattaaac gagcggcctg 1110601 gttcaaggat aatggtcatg gcaatcaata ggcttgcagt tgctataatg tcagggcttt 1110661 gtgtgaagag tccgatcagg tcttttgaaa agatcgtcat caaaacagag gtagccgcag 1110721 caattccgag tgcccaatat aagctcttca tgcagcgctc ataagcggca tcaaattgtt 1110781 tgccgccgat ataacggccg attaagattt gtgtaccctg gctgatcgca gtgccgaaca 1110841 gcaaaataaa catcgtaata ttttgcgtat acacttttgt tgtcaacgcc tgcgcgccca 1110901 tgatggcgat aaaatacgtg actatcattt gcgacaggtt gtatgaaagc tgctctcccg 1110961 cagaaggaat gccgattttc agcagcttgc gcaaatgctc tttatgcata tgaaagactt 1111021 ttttcagcga catcttcagc tggatgcgtt tgttgacaat cacaatcatc gcgattaatc 1111081 cgatgacgcg ggcgatagat gtggacatgg ccacaccggc aacaccgaga acaggaaagc 1111141 cgaacaaacc gaaaatcaca acaaagtttc cggcaatgtt taaaatgttc atgccgatag 1111201 tgacaaacat tgtatctttt gtgtagccgt agctttttaa gatcgcgctg aatgtcatga 1111261 ttaaagcctg aataaaggac agacctccga caacttgtaa aaagactttc gcatcaggca 1111321 tcagtgcgtc tgataatccc atcatatgaa gcagagggac agccgcgaaa aagacgacgg 1111381 cgctgatggc caggctgatg aagaagttgg cgccgattga cacataagcg acttccatgg 1111441 cttctttctt ttgccgtgag cctagaaatt gtgaaatgat aacggtcgtt cctgttgcga 1111501 taaagctgaa catcacgata attaaattta aaatctggtt gctgacgccg actgctgcca 1111561 cgctgttatc cgagtattgg ctgagcatca gtgtatcggc attacccata aacatatata 1111621 atgagacctc aataaagatc ggccaagtaa gcgaaaataa tgagaacgtt ttgtcagcgg 1111681 gttttttcaa agcagttgat ttgaagacag cttgtttcat cgtgtctaac ccctttcgta 1111741 aataaaatca acgttttaaa gtgtacctcc atttccttat aataaaaagg gatagaaacg 1111801 atacttcttg taaaaatccg acttaaaaag gaggatgatt caaatgcctc gcatcctgtt 1111861 tacagtcccg ccttttccgg tatttatcgc agctggggaa ggggttttta aaaaaggaga 1111921 aacccatgtg aaacgtgtat tctccgtgtt tgatctgata tatgtcaaac agggaacgtt 1111981 atatataacg gaaaatgaaa catcgttttc tgttgaaggc ggcgagtaca tcttgctttc 1112041 tcccggtctt gaacactacg ggacgaaggg cagtgatgaa gcaacctcct actattggct 1112101 tcacttcgat gaacatcgat atgaatttac ggcaaaggga ggcagcaact ggtctgagct 1112161 tcagcaggaa aaagggagct tcgaagagct ggcccgctac ggattggcct tgccgagaaa 1112221 aggcaaggtg cagcgcccgc agtttatggc gcagcagttt gaaaagctga tcgattactc 1112281 cgcggaaaac tctgatttgc cgctcagaaa gcaaatttta tttgaggagc tgatgctgca 1112341 tcttcaaaaa gaagcgttcc aaataccgtc tgcgaaagag cgggtagcct gggaggcggc 1112401 ccggtattta caggagcact ataaggaaaa gacgacaatc aaggatctgt cgctcgccct 1112461 tcactatcat caggattatg tgagccgctg catgcagcag gtgctcggcg taactccggc 1112521 acaatacacg aaccgggtga gaatgacgga agcgaagcgt cttttatcct ctacaaatga 1112581 taaaatgggc gttattgcgg aaacggtcgg aatggaagat ccgacatact tttcaaaact 1112641 ctttaagcag atagaaggca tttcaccaat tgaataccgg aaaattgtca gccggaaagt 1112701 tcaataacca gacgagggat gaacatgaaa acaacaattt acgatgtggc aaaggcggcg 1112761 ggtgtttcga tcacaactgt gtcccgtgtg ataaacaata cggggagaat cagcgataaa 1112821 acacggcaga aggtcatgaa tgtcatgaat gaaatggcat acacgcccaa tgtccacgcc 1112881 gcggcgttaa cgggaaaacg aacgaatatg atcgctctcg tggcgcctga tatttcaaat 1112941 ccgttttacg gcgaactggc caaaagcatt gaggaaagag cggatgagct cggttttcaa 1113001 atgttgattt gcagcaccga ttacgatccg aaaaaagaaa caaagtattt ttctgtgctg 1113061 aaacagaaaa aggtggatgg cattattttt gcaacaggga ttgaaagcca tgacagtatg 1113121 tctgctttgg aggaaatcgc cagtgaacaa attccgattg ccatgatttc tcaggataag 1113181 ccgcttcttc cgatggatat tgttgtgata gacgacgttc gtggcggata tgaggctgcc 1113241 aagcatcttc tgtcactcgg ccacacgaac atcgcctgca ttatcggaga cgggtcaacg 1113301 acaggcgaaa aaaatagaat caaaggcttc cgtcaggcga tggaggaagc gggcgtgccc 1113361 attgatgaat cacttatcat ccagacgcgg ttttccttgg aaagcggcaa ggaagaagcg 1113421 ggaaaattgc tcgacagaaa tgctccgact gctatttttg ccttcaacga cgtattggct 1113481 tgtgccgcca tacaagctgc gagaataaga ggcataaaag tgccggatga tctttctatc 1113541 attggttttg ataatacgat actcgcagaa atggcggctc cgcccctgac aaccgtagcc 1113601 cagccgataa aagagatggg gcggagcgtc atcgaactgc tggcagaagc aatagaggga 1113661 aaacgaaagg cgaaacaaaa aatagtgctc ccgcctgagc ttgtagtcag acattctaca 1113721 tcaccgctca acacatgagc ccgctaatga gcgggttttt tcattatgac agttgaagcc 1113781 aaaaaaacat attgcgtgta aaccaaaggc ggtgtaaaat ataaccatct tttgagaaag 1113841 cgcttgcgca aaatggcaga gcggatagaa ccgctgtttt tttagctgtt aagagaaaac 1113901 gctttctcaa agcgagcccg aaatgagata aaggagagga tgggacgtgg aacatcaagt 1113961 aagatgtgca gtattgggat taggaaggct cggttattat catgcgaaaa atctcgtcac 1114021 cagtgtgccg ggggcaaagc tggtttgtgt cggtgatccg ttaaaaggga gagcggagca 1114081 ggttgccaga gaactcggta tcgaaaaatg gtcagaggac ccgtatgaag tgttagaaga 1114141 tcccggcatt gatgctgtca ttatcgtaac gccgacaagc acacatggtg atatgatcat 1114201 caaagcagcc gagaacggca aacagatctt tgttgaaaaa ccgctgacat taagccttga 1114261 ggaatcaaaa gcagcttctg aaaaagttaa ggagacaggt gtcatctgcc aagtcggctt 1114321 tatgagacgg ttcgatcccg catacgcaga tgccaaacgg cggatcgacg ctggagaaat 1114381 cggcaaacct atctattata aaggctttac gcgcgaccaa ggcgcgcctc ccgcagaatt 1114441 tatcaaacac agcggtggaa tttttatcga ctgttccatc catgactatg atattgcccg 1114501 ttatttgcta ggggcggaaa tcacttctgt ttcaggacac ggcaggattc tgaacaatcc 1114561 gtttatggag cagtatggcg atgtggatca ggcgctgacg tatattgaat ttgactcggg 1114621 cgcagcgggg gacgtcgagg caagcagaac ctctccatac ggacatgaca tccgggcgga 1114681 ggtgatcggg acagagggca gtattttcat agggacattg agacatcaac atgtgaccat 1114741 cctatcggct aaagggagca gttttgatat cattccagac tttcaaactc gttttcatga 1114801 agcctactgc ttggagcttc agcatttcgc cgagtgtgtc cggaatggaa aaacaccgat 1114861 tgtgactgat attgatgcga cgatcaattt agaagtgggt atcgccgcaa ccaattcctt 1114921 tcgaaacggc atgccggtac agctagatgt gaagcgcgct tatacaggta tgtaaaagct 1114981 aagtatgttg catttgaggc tttccgcaaa aaaagcaagg gcattttagc ccttgctttc 1115041 tcttttctca tataaatagt acatataatc agtaggtacg cctgaatggt ccagctgtct 1115101 cagcatggcg gttacgttcc ctctgtggta agtgccgtga ttgacgacat gcaggatggt 1115161 gtctgcatag gttgattcca gtgtacctag tttcggatgc tgcattgtga aggtctgttc 1115221 taagtccgtc tggcggctga agaaatcatg atactgtgac tccagctcgg cagcgtgctg 1115281 tttaatcgct gccatattac cttgcgcgga ctgtaatttg cctgcgctgt ctataatctc 1115341 ttggtaggcc actcccgaaa gaacattcag ccaaatgtag tcagccctgc acatatgaag 1115401 cagcacgtcg ctgacagaag gaaatacgct ctttacttct tgataggcag tttcctccgg 1115461 caggttttcg atatgggtaa atattttctt gtttgcccaa gaatgatagt cataaaactg 1115521 ttttgcatca gtcatcagca tgcccccttt tctaagaaat tcgttttttt catctgtttc 1115581 tccttcaatt gcaaaagagt gacaccccaa aatatcctgc cgctgcccac attaccgctg 1115641 cagagcattt gtttacgatc agcataagcc tgccgctcgt atctatcgtc tgaaacaacc 1115701 ggcccgctat tgcaaggctg atgaaccaaa tccaagacac agcgatgcag gcggccataa 1115761 agagccattt ctcaagcccc gaatattgaa gagagctcgt gccgatgacg ccgatcgtgt 1115821 ccagaatggc atgcgggttt aaaagagaaa cagcggccgc aaacgcagct tgcttttttg 1115881 gtgtgaacgt atgtttctca ttttggcttg tgttcggacg gatgttccaa gtcacccagc 1115941 ccatataaag caaaaataaa aatccgccgg ccatcatgac tgtctcaaac acaggcagct 1116001 cctgcacaat gacagacacg cccgcaacgg ctaatacaat taacaaggta tcgcagactg 1116061 aagcactgat gacagctggg agagcccgcc aaatatgctt ttgcaacgcg ccttgctgaa 1116121 aaataaacac attctgcact cccagcggca aaattaagcc aaacgcgagc acaattccgt 1116181 gaatgattgc attcatgctg aaaaagctcc tttcacattt tttttcaatc ataagagaga 1116241 ttgtcactaa agtctccagc catttggttg ggttaggaac cagccaaatg tataatgtgt 1116301 aaaaaagggg ggcatgacct tgtcgcaatg gcagccaagc cgaaagtcgg atgttccgct 1116361 gcatcggcag atcgaacaat atatgaaaga caagattctt cacggagagt gggctgtagg 1116421 gacgaaaatc ccctcacaga gaacgctggc cgacatgttt caagtcaacc gcagcacagt 1116481 cacagcagcc atagatgaac tcacgtctca aggcttgtta gagggaagaa aaggcggcgg 1116541 tacgaaggtt gtaaacagta cttggagcgt gctgacggct gagcctccgc ttgattggag 1116601 cgattacgtc cgttcgggca ttcatcgcgc caattcttcc atcattcaag ctattaatca 1116661 gaacgaacca agagcggata tcatcagatt aggaactgga gaactttcac cggatcttgt 1116721 gcctgctgac acaattggac ggatgtttca gcaaatcaat ccgggcgtcc tgtctttagg 1116781 atatgagcag ccgaaaggaa accgtcagct gcgggaggca gtggccgacc atttaaaagg 1116841 aaagaagatc catgtgtcac cgtctgcaat tttaattgtg tccggtgcac ttcaggcact 1116901 tcagctcatc tcaattggac ttttaaaacg agattctgtc attttgacgg agaagccgtc 1116961 ctaccttcaa tccttgcatg tatttcaatc agctgggatg cggcttcgcg gcttgccgat 1117021 ggatgatgaa ggggtcaaag cggggcttgt ttcttctaat cgaaaacaat atggaggaca 1117081 gctgctttac acgattccgt cgtttcataa tccgacaggc acagtcatgt cagagcagcg 1117141 aaggaaagag atcatcagcc tgtcaaaaaa agagcagatg cccatcattg aggatgatgc 1117201 gtacggtgat ttatggtttg aagaaaaacc gccgcagccg ttgaaagcaa tggatcatga 1117261 gggcaatatt ctgtatctgg gcgcgttttc aaaaacggtt agccccggtc tgcgaatcgg 1117321 ctggcttgcc ggtccggagc cggttattga aaggctggcg gacattaaaa tgcagacaga 1117381 ctacggatca agcggcctgt cccagtgggc ggctgccgag tggctgtcac agggatatta 1117441 tgaagagcat ctgacttggg tacgcaggaa gcttaaagaa aggagagacg ccgccgttca 1117501 ttttctcgag cggtatgccg gggacattgc cacgtggcgg attcccgcag gcggctttta 1117561 tatttgggtg acatttcaca aaaacctgcc tgtcagccgt ttcttttatg aattgctgaa 1117621 acggcaggtg cttgtgaatc ccggctatat ttatgacggt gaagaccgaa acagcatcag 1117681 gctgtcatat tcctatgcat ctcttggaga tttggaaact ggcattaaag cggcagctga 1117741 aacagcacgc cgcctgatga tgtcctaggc tttggttata cgatgacagc tcccagtgcc 1117801 ctggcgaagg caatcgcgtg ctcaggtgcg attttgcagc ctttcaattt gtcgagggag 1117861 acatgaagct gttcaaaacg gcacgtgctg atgtccatgt tttgaaggga cgtgccggta 1117921 aagctggcgc cttccaattc gcatccgtca aagtgtgtct gctggagcac cgtatcgctg 1117981 cattcacttt gcataagagc acagtgatca aatcgaactt gtttcatatt tgagtacgaa 1118041 aatgagctga aatgtccgtg gcattcctcg aatgaaacat tccgcagcgt tgcttccgcc 1118101 acattcattc caaccatttt tgactgctta actgaagttc tgtgaatgac agccccgctg 1118161 aaatcggcgt ttgataaatc gcatttttca aagatcacat cggtcagttc aatatgccga 1118221 aaagacacat cgataaagac gacatttctg aataccgttt tttcaacaca tagtctttcg 1118281 atatcttcgc cgcagatggt gcaatcttca aacaaatgca tgctgattac atcatcctgt 1118341 gtcacggcat catgaaaatc tgcggtttgc aggttttccg gtatgttcgg tttttgaatt 1118401 gcgattttat tcatgtgatg acatcctttg ctgcccgaaa aacagaggct tccgggttca 1118461 atttaataga tcgttaagga aattgataca tatagtaaat cgtgaagagc cttttcttgg 1118521 tacagcagcc cgcttgtttt gtaagcataa atggaaagct tcctatacgt caaggcgttt 1118581 acaggccgaa aaagccaaag ggaacaggag gaatgcggaa tggggcatta catcaaaacc 1118641 gaggagcatg tgacactgtt tgtagaggat atcggacatg gaaggccgat catctttttg 1118701 cacgggtggc cgttgaatca taagatgttt gaatatcaaa tgaatgagct tccgaaaagg 1118761 ggatttcgtt ttatcggcgt tgatttgcgg ggatatgggc aatctgaccg cccttgggaa 1118821 ggctacgatt atgacacgat ggccgatgat gtgaaagcag tcatttatac gctgcagctt 1118881 gagaatgcga ttcttgccgg tttttcaatg ggcggcgcaa ttgcaatccg ttatatggca 1118941 aggcatgaag gagccgatgt tgataagctg attttactgt ctgcggcggc ccccgcgttt 1119001 acaaaacgcc cgggttatcc gtacgggatg aggaagcagg atattgacga tatgattgaa 1119061 ttgttcaaag ctgatcggcc caaaacactg gctgatttag ggaaacagtt ttttgagaaa 1119121 aaagtgtctc cagagcttag gcagtggttt ctcaatctga tgctggaggc ttcctcctac 1119181 gggacgatcc actcgggcat cgcattaaga gacgaagatc tcagaaagga acttgctgca 1119241 atcaaggtgc cgacgctgat cctgcacggg agaaaggata gaattgcgcc gtttgatttt 1119301 gcgaaagaat tgaagcgcgg catcaaacag tcggaattgg ttccgtttgc aaacagcggg 1119361 cacggagcat tttatgagga aaaagagaag atcaacagtt tgattgcgca gttctccaac 1119421 tcataagaaa aaacccgaca ttgatcgggt tttttatata attcctctgt tttgcagtgc 1119481 gttaatgatg agatcagctc catcggaaat agaggtctgg tcagactcaa tgatgaaatc 1119541 gggtgaaagc ggcgcttcat acggagaatc gatcccggtg aaatgtttga tctctccgtt 1119601 tcgcgctttt ttataaagcc cttttggatc gcgctgttca caaacatgca gcgggcactt 1119661 cacataaatt tcgaagaact cacctttagg aaagagcgct ctaaccatgt cccgatcctc 1119721 tctgaatgga gaaataaaag ccgttaaaat catttgcccg ctgtcgacaa acagcttcgc 1119781 cacttctccg atccggcgga tgttttcaat cctgtcacca gtctgaaatc caagatcttt 1119841 gtttaagccg tggcggatat tatcaccgtc aagcacgtag ctctgaatgc ccttgcggta 1119901 aagcttttca tcgacagcat tggccagcac cgattttccg gagccggaca aacctgtaaa 1119961 ccaaaggacg cagcttttgt gtccgtttaa ggactgtctg tcagactttg agatggcagc 1120021 gggatgccaa atgatgttcg gattgtgtgt cattgcaatt ccccgctgtt ttgcttgatg 1120081 gcaacaggct gttggtgaag tcccttgatc agcacggctg cgacctcagg ccggctgaat 1120141 tctttaggcg gctttttgcc ttggcggaga agctctctca cttttgtgcc tgataagtgg 1120201 atgtggtctc tcgggctgtg cggacatgtt ttggaggtgc ccatgtttcc gcattttcgg 1120261 caataaaagc tgtgctcaaa aaacagcggc ttgatgccca gctcttcctc tgtgaatgat 1120321 tgaaaaatat tttgggcgtc gtatgttcca tagtagctgc cgacacccgc gtgatcacgg 1120381 cctacaataa aatgggtaca gccgtaattt tttcggacga gcgcatggaa aatcgcttcc 1120441 cgcggacctg cataacgcat ggcggcaggg aaaaccgata acatgacacg atcctttgga 1120501 taatagtgat taagcaaagc ctggtagctc tccattctga tatcgctggg gatatcgtct 1120561 gactttgttt ctccgacaag tgggtgaagc agcagaccgt cgaccgtttc taacgctgtt 1120621 ttttgaatgt attcatgcgc tctgtgaaca gggttcctgg tttgaaagcc gacaatcgtc 1120681 ttccagccga gtttttgaaa ggccgctctt gtttcagcgg gcgttgcata aaactgttcg 1120741 aaagatttgt caggcaggct gctgaccgtg ataggccctc cgatatagta atccgggcgc 1120801 gccagcaatt tttttacgcc tgggtgggca ggatcgtttg ttttaaaaac agacagtgct 1120861 tcttgtgttt tatcaggctg gtatatatcg gtgactgtga tcatgccgta ggtaacaccg 1120921 tctttcacaa gcttgacgtg atctccggca gacagctgtc ttgctgtttt ttctccgaca 1120981 ggcagcgtaa tcggcaggct ccacggcaag ccgtttgcca gcctcatctc tttcacaacg 1121041 gaatgataat ctttttctcc caaaaaacct gttaacgggc tgtagccgcc gatcgcaata 1121101 agctccagat cactcagtgc aagctgatcc agctctgctt ggcacgcgca cccttcaaaa 1121161 tggcatgcgg gatcacagcg gttgattaat acccctccgt ggggttcgtt tccattcaac 1121221 gtgttcaacc tccatttata cgtttccttg ttttcttttc tgcacttaat gaaagtttga 1121281 catcagcgcc ttaacatcat ttcgattctc acatcaagaa cctgccatcc gctattcttg 1121341 atgcaggccg cattctgttt tctcccgtcc ggcccatctt ccagccctct catcgttcgg 1121401 gtccggggaa ggcagtgtac acatttcaca gcctatgctc ggataatgtt gatcgtgcag 1121461 tttgttataa ggcaaattgt gcaggcggat gtacgtccaa acgtcatccc atgtccagtg 1121521 gataagcggg caaattttga tgagctcaaa cttctggtcc aggtttacgt attgaatatg 1121581 ctttctcgtt ggtgactgat cccggcgcag tcctgaaatc caagctgtca tgccggacag 1121641 gtgctttttg agcggttcga ttttccgcaa ttggcagcag aggttcgggt tatgcttcca 1121701 cagctctccg ccgtacttcg tcccctgttc tgttaagctc agctcgggtt cgagcatctg 1121761 gattgcaaat cccggatatc gttctttgac ggtctcgatc agctcatatg tttcctgaaa 1121821 atgaagcccg gtatccaaaa agatgatgtg tgcgtttttg ttgatttttg atattaagtc 1121881 gagaagcacc attccttctg cgccaaagct gcaggcgtac acaatctttt ctccgtacgt 1121941 tcggtaagcc catttcaaca catcgagctc atcgatcaat tgatccgtta tctgtttgga 1122001 cagcatgtcg ttccaagtgt catatgtgat ggtttcgttc aatgttttcc ccccgtttgc 1122061 atctgctttt tttatctatt gatcgagtta taggcagact attcattttt tgcataaagg 1122121 ttcaggtttt aggtgccgcg cccgcctaaa atgaggtgcg gaaccattaa gagcccggct 1122181 gaatatgctt tttagcaaaa tggttttatg cccaaggaga ggtagtatgc cgattgccat 1122241 ttatcagggg catcatcatt cgcttgcccc ggcggacatt aacatcgtca ttgatgtcat 1122301 cagagccttt acggtcgccc attatgcgtt tatcggcggg gcgaaagaga ttttgttggt 1122361 ccggacagct gatgaagcct ttgcgctgaa agacacctat ccggattatg ttttgacggg 1122421 agaggaaaag ggggtcggta tcagcggatt tgatttagat aattctccaa aacgtatggc 1122481 tgggcagaat atgacggata aaagcctgat ccagaaaaca acaaacggcg tcacagcagc 1122541 attgggggcg ctgaacgcaa agcatctgtt cgtaactgga ttttccaatg ccaaaacaac 1122601 ggcacagcat gtgaaaaagc tcgtcgcaaa cgattgtgtc ataaacatag tggcttccca 1122661 tccatccggt gatgacgata tggcatgtgc ggagtatatc aaaggcatca ttgaagggac 1122721 aaatgtggta acggctgcgg aggcgattga aagaataaaa ggctcttctg ttgcggagaa 1122781 gttttttgac tgccgccagc cattgtttga ttcggaagac atcgtttact gtacaaaaga 1122841 actgacgggc gatttcgtga tgaaagtgaa acaagatgga gaagttccaa cgatagagag 1122901 ggtcataata tgaatgattt ttcactagaa ttgccagtga gaacaaacaa gccgagagaa 1122961 accgggcagt ccattttaat tgataacggc tatcccttgc aatttttcaa agatgcgata 1123021 gccggagcgt ccgactatat tgattttgtg aaattcggct ggggcacatc attacttacg 1123081 aaagatcttg aagaaaaaat cagcacactg aaagaacatg acattacatt tttctttggc 1123141 ggcacactgt ttgaaaagta cgtaagccag aaaaaagtga atgaatttca tcggtactgc 1123201 acctatttcg gctgtgaata tattgagatt tcaaacggta cgctcccgat gacaaataaa 1123261 gagaaagcgg cttacattgc cgatttttct gatgaatttc ttgtgctcag tgaggtgggc 1123321 agcaaggatg cggaattagc aagccggcaa agctctgagg aatggcttga atatatcgtt 1123381 gaggatatgg aagcgggcgc ggaaaaagtg attacagaag ccagagaaag cggaacggga 1123441 gggatctgtt ccagcagcgg cgatgtcagg tttcaaattg ttgacgacat catttcctcg 1123501 gatattgata tcaacaggct gatttttgaa gcgcctaaca aaacgcttca gcaagggttt 1123561 attcaaaaaa tcgggccgaa tgtgaatctt gccaatattc catttcatga tgccatcgcg 1123621 ttggaaacgc tgcgtttagg gctaagatcc gatacctttt ttctgtaaaa tagcggctgc 1123681 ggggctctcg tcgtgaagag agcctctgcc tattattttt tatggcggta cataggcgtg 1123741 agatagggaa gtgaggtcag gcggatgttg tagatgaagt cgatgactct tgtcgatatc 1123801 acctggcata tgagggcttg aatgacgatg ccccagtcaa taatagacgc ggtgaccata 1123861 aaaatgatgc aattcatgat gagcaggatc gttccaggat tcccgccgcg gtagatagaa 1123921 atcatcagag caagggctcc gaatcctccg ttcgaaattt tatatttgta taaaagtccg 1123981 attccgagtc ccaataacac tgcgccgctt gccagatcaa gccacaggtt agatgtgata 1124041 tcaggaaaaa ctgcatcaaa gatcaatacc gagacagagg tgacggtgat agaagcgagg 1124101 gtgccggtga atgttctcat ctccagccat tttaaagcgg taaaaagcat tgatacattc 1124161 acagcccaca ctgaaaatcc gtgggggatt tgaaacagat aatgcaatag caccgcaata 1124221 cctgctgcac cgcctgtcgg aatatcatgc ggaaataaaa acaaggacat gccgagtcct 1124281 tgtagtacgc cgcctacgac aatcataaac gtaagttttg ctttcatcag cagttcagcc 1124341 attaagtcat ttgctccttt atgaaaagac ttgtccgctg ttttcatttt atgaggctgt 1124401 ccattattta tgtctcaaaa taaagaaatg gcccagctta ataggctgag ccatcccact 1124461 tgtagcgatt gacgatctcc atattgatct ctgtgccaat gccttttcct ttcgggatgt 1124521 ggaccattcc ttttgaaggc tgcaggctga cgagatctgt aaaaggattc tccatgacgt 1124581 cccactcgat cggttcaatg tgatcgttct tcattttaga ccatgggggc agacaggctt 1124641 gtgcaaataa agcatagagc cgtgagagcg atccgtcata tgcatgggcg gatgctctga 1124701 cgccgaaata acgcgcgagc tggaggcagt cccgaaactc atcaattccg ttgacatgca 1124761 tgacatcggg ctgaatgata tccaaacagc gctgtgaaag gagaggcaca tattgcgccg 1124821 ggcctttcat gttttctccg ccggcaacag gaacagacaa acggcttcga agcatagcgt 1124881 aatcctgcgg ctgatcaaag ggcaaaggct cctcaagcca gccaatgttc gtccattcgg 1124941 agaaatagcg ctcccattta aaagccgcag cggcatcgta gctttggttt gcgtccagaa 1125001 tcatcgtaat ggagctgcct gctgtatgct gcagcgcatt gatgtgccgg acatcctcct 1125061 tgaatgaagt cccgccaatt ttgactttga tttgctcaaa accttttttc aactgggctt 1125121 caacattgga gactgagcgg ctgatccatt gcggggagtc tgagtacgat tgaaaagacg 1125181 cgtacacagg aatctcctct ctgtatcgcc cgccccataa ttcgcaaacc gaacaatccg 1125241 cagctttggc tgcaatctct gtcagcgcca tgcttacagc ggaggccgcc cgctggtgcc 1125301 atttttgaat cgtgcgcact aatgacaggc ggctgccagc ctgttttcct aatagaaatg 1125361 ggatgatccg cttcgtaaaa ccgacatgga gagcagggag ccaatcaacg cattctcccc 1125421 agccgtctat cccgctttcg gtgataatcc tgatgagata acaagtccga tatcgtttaa 1125481 acccattggc atctccgtat ggcttttcta atcgatgaaa tagcggaaag gtttcaatcc 1125541 gtacaatttt cacactgggt gctacctttc ctcagcgggc tggagccgat tgccagccat 1125601 tttagggtct tctttttctt ttgtttcttc attgttttgc ttcacatgga tgagcatcat 1125661 cacaagaatc ccgacaacga gagtcaatcc cgcgatgctt aaaaacatgc cgggtctgga 1125721 ccattgcatc aggcggccga aaatcggagg accgatcgct acccctaaga aacgtacaga 1125781 gccgtacagc gaggtgacaa atccccgtct ttctttgccg acagccccgg taatgaaact 1125841 gttcacacaa ggaaggacaa gacctgagcc tatactgctc agtacaagaa cactgataaa 1125901 aaggacaaga ttttcaatga atgacagtgc cgcgtaggat acggtcatga acgccaatcc 1125961 aagtacgatc agctttttca ttaacgattg cttttgcccg attttgcttc ctgttgtata 1126021 ggacgtcaca cacataacca aaagcgggat cgctaaaatt aagccttttt tcacgccgtc 1126081 ggtgtcgtat gttttttcaa gaacatctga gagataaaac aggatgccga ataaagtaaa 1126141 caaacaggtc gcaccggcta aataagcggt aaacagccat ctgccttcat gtttaaagac 1126201 acttaacagc ccttttgcat attgtccgat tggtggcggt tctttttcct ttttcttttc 1126261 tttaataaaa atccaagtca gtacgatcga aatgatacaa aacacaggaa aggcaaaaaa 1126321 cgcgccatac cagacaagca gggcgatcag cgagccaatg atcggcgata gcactttccc 1126381 catgccgttt gaagcttcaa caaggccgag caccttgctc tcctgggcgc ctttaaacag 1126441 atctcccgtc agtgccatgg caattgggcc ggttccggct gccccgattc cctgtaacgc 1126501 tcgtcctgcc atgacccaag gataggcatt gtcaaaaaaa cctgccgcaa acccggctaa 1126561 caaaccgccg gcaccataca aaattaagca gggaataatg atgactttcc ttgagaatcg 1126621 gtctgcgaga taaccgacaa tcggaatcgc aaatgctgca atcaaggaaa atactgtgat 1126681 cacgagactg acttgaaatt gtgataaatg aagttcagat ttcatttttg gcaaaatcgg 1126741 aataagcatc gagtttccta gggttaatat taaagggatt gaaccgattg ccacaatcgt 1126801 cattccgtta ttttgttttg atgattccat ctcagagcac actccttttc ttctgcttag 1126861 aatgtccctg atggcttcgt ttattcagcg atcagacagc aaaaaaccga acagaagata 1126921 cctgttcggg aaaaaagagg gttaaccgag agcctgtgaa atcaaagcat ataagtgtcc 1126981 attttgaata ggcgcttttt tctgatagaa caaaatcgga ggttcatcat ctttatgaaa 1127041 tcccatttct atcaggctgt catgcagaga cgtgtgttca ctcggtatat cgattcgcat 1127101 cggcccttgt ttgccggccg ccagccttgt aattatctgt gctgcaacat ctgatgatgg 1127161 agcgatgata gggccgaatt tcaaattggc cggtgtctgt acagaaagtc cgtagccaat 1127221 gagctgtccg tcctgatttc tggcgatgat acattcgcat gaagcagaaa taagctgctg 1127281 caaaaggttt gatcgatctc cgccaaaggc agccagatcc gccgcggtta agtcgtgaaa 1127341 gtcttgttct ctaaaggatg tcagttcagc atcaagcttt tttgtataag gttgaaaact 1127401 gtgacagctg tactttcgca ctgaacctgc cgtatgaaaa cctgcttttt cataaagcgg 1127461 caaaccttct tttgtggcgc aaagcctgat ggcggtgttt tcatccgttt gggtaataca 1127521 ggcgtttacc atacgccggc caagaccgag ccgttgatat tccttgtcaa cgataacaag 1127581 gccgatagaa gtaagacggc caaacaaaaa caagccgatg caggaaataa tatcaccgct 1127641 gacattttga taaccgaaaa agcgtccctg ctgaacaagc agtttcagct cttgttcgcc 1127701 ataatccggc cacccggctt gcccgcaaag ccgcaataag ccggaaacgt gttcttcatg 1127761 aagcttaatc agttcatcta ctacgtccat aagatcacct gcttgttcta agtgttttgt 1127821 acatgacaat atgattgcca atgccgggaa tgtcaaatgg ttcgccaagt tccttccagc 1127881 caagcttggc atagtagccc ttgacatggt gtcttgcgtt gcaccatacc gcctgaacgc 1127941 cgctctccgc cagtttgtgc tccgcgtgtt tgatcagcgt gcttccagct ttttgatcgc 1128001 gatatccctc gagcgttgcc atgcctctca gccgatacgc agaggcttcc gttaataaag 1128061 gctgactttg cggggaaaaa gaagcgatgc tgatcagcgt tccatcataa aacacgccga 1128121 gatgaaagga gccttctgcg tgatcctctt tatatttgca ttgttcgatg gattgatggg 1128181 gacgcagaat gcgatgccgg atttcatatg tatcttccac ggaaatggtt ttgacttcga 1128241 gcataatgtt cctcctcatg attgtttttc tatatcgtaa cacgaatctc gttgaaaaag 1128301 actgcccgat tcgatcaggc agtcttttgg aaattaatgc aaaaagatat tttggcgctg 1128361 ctcatctttt tgctgaatat atgatgtgag ctcagcggtt aagtcagatc tgaggaaagg 1128421 cgttatcaag tagatgccgt taaacagctc gcatgccgta tccagcaggg agcgtgcaat 1128481 tgcaaggcct tccgcctttt gcttttcttt atcttcaccg gcatgggcca ttttttcgcg 1128541 aatcgtatca gacagcttaa tgccgggaat ttcattatgg atgaattcgg cattccggct 1128601 gcttgtcagc ggcatgatgc cgatatagat cggcgtcttc agatgttttg tttcgttatg 1128661 gatatcgaca agctgctgct cggaatagac aggctgagaa acaaaataat ctgcgccgca 1128721 atctattttt ttctcaagcc gttttaccgc tttatccaga tggcggacgt taggattaaa 1128781 tgcggcggca actgagaaat tcgttttctt gccgagcggt tttccagaca gagacagacc 1128841 ttcattgaat tgtttgatca gcctgattaa atcaaaagat gttaaatcat atacagacgt 1128901 cgccccagga aaatccccga ttttagaagg gtcacctgta atagcaagca cgtcattcag 1128961 ccctaacgta tcaaggccca ttaaatgtga ctgtaagccg ataatgttac ggtcacggca 1129021 cgtaatatgg acaagggaac gcatatcgag ctgctgcttg acaagggcgc cgcaggcaac 1129081 attgctgatc cgcggggtcg ccaaagaatt gtcggcgagt gtcagggcat cgattcccgc 1129141 ttcttttaat tcagcagcag cggacagaaa tttgtcaaag cttagttttt tcggcgggtc 1129201 cagctctacg ataatagagc gttttttcgc tgcgatctca tccaggccgg gctcggttcg 1129261 ctcgtgatga acagaaatga attctttcgc ccgggttttg acttcttttt ccgtaatcgg 1129321 agccagcccg ccaaccgctt ccgccatcgc cctgatgtga ttcggcgttg tgccgcagca 1129381 gccgccgata atccgcgcac cttgcttacg gaattctgac gcgctgtttt gaaaatacgt 1129441 gtcgtctgtt tcatagacga gccgtccctc ttcaagcgaa ggaagactgc tgttcggata 1129501 aacggataag aatacgtcat caaaaatcgg cacttcgctt agcgcttcaa tcatgtgata 1129561 agggccgagg cggcagttaa tgccgacaat atcagctccg agatccgcaa tcgagcgcaa 1129621 tgcgtcagaa agcggcgttc cgtcctgcaa tacgccttgc tcgtgcatgg agacattgag 1129681 cataatcgga agatcagtct ctttgcgcgc gattttcagc acttcacggg cttcttccaa 1129741 atcataatat gtttctaaca gcaagccatc cggctcttca tgcagcagca gatacagctg 1129801 ctcgcggaag ctgcgcttaa tttcgtcaag actgtatgcg tttttattaa atgtgcgtat 1129861 gccgcccatc gttccaagca cgtatgcatc gcctgctgaa gcccgcgcga tctttacggc 1129921 ctcctgattc atttttttga tgtcatcctc aagcccgtgt ctggataatt taatatagtt 1129981 ggctccgtac gtattcgttt gaataatgtt ggctcccgct tcaacgtacg ctttatgtat 1130041 gcgctgaatt tcctccggct ttgaaatatt gagctcctca aaacacctgt caatgccata 1130101 ggagtagagg agcgtcccca tggcgccgtc accgattaac acctgtcttt gcaaatcttc 1130161 taaaagtccc attgtctgcc tcctttattc acatcagcaa ggaaaaaaga gaaataaaaa 1130221 aagtcctctt aagaagaaga ctttgtcagt gattttgtct cttcttatct tccaagctgt 1130281 tcgagcttgc tggatttagc accttggtca tggctgatcg ccattacacc ggttgctgaa 1130341 gcttcgtcgg gccagtccct ctgcttctct tgataagaac ggatatgaaa ttttcgtgtc 1130401 aggaagtgcc aaaagatatc tggcgttttt ccctttctcc aaatttaccg aaaataaaga 1130461 caataatcaa taggaatcag aaaatttatc tgaaatttat aaattgaacg tcaattggca 1130521 gatctgctcc ccgtacagct gagataatct gctgcaggtc atctttgttt tttccggtga 1130581 cacgcacttg atcatcctgc acctgagact ttactttcag tccggagttt ttgatgatcg 1130641 tattgatttt ttttgcgttg tccttgtcaa tgccttgaac aagctttgca cgctggcgca 1130701 ccgttccgcc tgacgcgttt tcaaccttgc cgtaatcaat gttttttgtc ggtacgtttc 1130761 gtttaatcaa tttgctgacc agcacatctt tcagctggct taatttgaat tcgtcatcgg 1130821 aaacgaggac cagctcctct ttatctaaag aaatgtcgct tttgctgcct ttaaagtcat 1130881 atcgggtact gatttccttc agtgcgattt ggattgcgtt ttgcacttca ggcaattcca 1130941 ccttggatac aatatcaaat gaactttctt ttgccatatg aaaacctcca taacatttaa 1131001 cttatgtgtt gattatagta gaataaagag aaacttccaa cagaacaaag aatcaatttg 1131061 tgatgattgg aaaaaatgtt aacaaaatcc gcagagaata agcggaacag gaaggacgat 1131121 agcatgagac cagggcagca attaaccttg agtatagatc accaaaccga cttcggttac 1131181 tttttaaccg atggggaaga tacgattctc ttacataaca gtgaaatgac tgaggatatc 1131241 gaggacagag acgaagtaga agtctttata tacgtagacc agcaggaaag gcttgcggcc 1131301 acgatgaaaa ttccgatcat cagcgcggat gaatatggct gggttgaagt ggtggataaa 1131361 gtggaagata tgggcgtttt cgttgatgtc ggtttatcga aggacgcact agtcgcaact 1131421 gagcatttgc cgccgtacga agatgtctgg ccgcaaaaag gggacaaact ttactgtatg 1131481 ctgaaggtga cgaaccgggg gcgcatgttt gcgaaaccag cgccggaaga tatcatcagc 1131541 gaactgttta ccgacgcttc agaagatctg atgaataaag agctgacagg tacggtgtac 1131601 aggctgatcg catcgggttc attcgtgatc acggatgacg gtatccgctg ttttattcac 1131661 ccgtcagaaa gaaaagagga gccaagactg ggttcaagag tcacaggccg ggtgattcaa 1131721 gtgaaagaag acggttcagt caacttgtcg ctgcttccga gaaaacagga tgcaatgtca 1131781 gttgatgctg agtgcattct aacgtatatg agaatgagaa acggtgccat gccgtacagt 1131841 gacaaaagcc agcctgacga tatcagagaa cgttttaata tgagcaaagc cgcctttaaa 1131901 cgcgcgctgg gccatttgat gaaaaacgga aaagtgtatc aggaaaatgg atggacatac 1131961 gagaaaaaat agcatgaaaa cggctcgcct gcagcagact gcggagcgag ccgttttttt 1132021 atgtctagtt taattcatca accagcgttc tgattgccat ttcgcgatcc acattgtctg 1132081 aaatcgcaat cggcgtaata tcaatggcga gaatgatcag aatcagggca cctgctgcag 1132141 caacataaga aacataatag aaatagttag cggtatcaac agtgttgaca agctcggcct 1132201 gaactctgga tgtatcatcc ttagaagcgg cgatttcctt tgcagcttct actttttctt 1132261 caacgatttg acctgctttt ttcagcagtt catccacttt caatgcatct ttgctgtaaa 1132321 cagctttctt caggttatca aaaaagtcag catcctcttt tttaatatca gcgacaacct 1132381 gattggcaaa agcctttgcc tgttttgtgt tgagtttgtc tgtcatcgct ttattaaaga 1132441 cctctggaag ctgtttgcca acttcccctt gggcaaacac aaagccttta aaaatttcct 1132501 cacctgaata ctcaagctgc tttgcctgtg ccacactttc ttgctgcttc accaaaaaca 1132561 cagtcgtcac caatacaacc gacaaaaata ctagaaacgc cttcttcaaa ctgaaacctc 1132621 tcccttcttg tgttttttat tccacaacag tctgcgaata tatgtaaatt gaatcgtgga 1132681 atcgatagga gtgagataca atatcaaaat gccggccatg ataatcgaaa aactgatgag 1132741 gcccagcatg actgcaaaaa tctcatgcat aaaaacagcg atgatcaaaa tcaatctcca 1132801 atgcttcttc ggcgcaaaca gtgccgcgaa gatgacaatt tgaaccagca gcgtccccca 1132861 tgtcggaatc accacgaacg gacttgttac aattggcttc gttaacgcct gaaaaaagcc 1132921 gttgaagcca atggtttttt cctgggcgaa ataatagacg gccgttccgt ccacccattc 1132981 ctgctgagat agcttagcga cggtagagtg aaaataaagc accgccactt ggattctgat 1133041 cacaaaataa gaaataaaag ctgttatttt tccaagtgtt cttttgccct ctataggtct 1133101 cgtactccaa tgccattttc tcggatcggt cagcgtgatg ggaagcaata aaaaggtcat 1133161 gactgctgct gcctgctcgc ctccgtcgat gacgatcagc gatgactgca ggctgtaact 1133221 gacataccaa tgcagaaccc cggtgattct ggggcgccag ccaatgacaa caagcaccag 1133281 aatggcaatg cagacccatc tgaaaagatt taacatcata tagttatttt cgccgagaca 1133341 aaagagactg agattcattt tacaagctgg atagctgctg atcccgctgg ctggcttcat 1133401 aatgaggctc gggtgattga tgagcagcgt cagcaggctg gatagcgcaa tgatgcttcg 1133461 cgcgaggcca tatacatttg tccacgggtt tctttcgtcc catctggtga tggtctgttt 1133521 tatgttttcg agcatgagat cacaaccttg actatgcttt ttacctgata agacgaaggg 1133581 gtatatttag aatagctcca aggaacaata tcctctttcg tcaaatagta gctgccacaa 1133641 agcagcgggc ggggagcggg tgtttttaat tgcacggttt tggctttgct tttgcatgcg 1133701 ccgaggtcct tttctttaca tgctgtccac tgttccttgc cgacttggct gtagatcacg 1133761 cccatttcaa cgccttgtga ccgcccatac cgatacaggc cgaataggtt gtcagccctc 1133821 atattgggcc atctgacctt ggcgctggca ttttcagcct catataagcc gattgcagta 1133881 tcacgcggat ttttgctaaa aaagccccag ccctgaggga ggatgctgga catgagaaat 1133941 ttggagtcct ttgtcagcgg aatcggggtt gtccctaagc tgccaataat agaaaacaga 1134001 aatagcgaac cccaaaggat tgaaaaaatg acaaaaaatg atatcgattt ctgcattcga 1134061 ctgctccttt taacctgaag aatcgttttt acacttttca taatataaaa acatttatgt 1134121 aataaaaagg ttaaaaagta tgagaaattc catttttgtt aaaaggaaaa acaggacatt 1134181 ttacactgct atatgtgatt gatatatagt gtttttttcg atatatttaa accatgaaaa 1134241 cgaatcaagt taatgaccgc tggattgttc aatttcgaaa agggattttc gagctggcca 1134301 tcctatccct tctgcgttct aaaccgatgt acggttatga gctgacgtca tccttaaaaa 1134361 ccacctcggc gctggctatt tcagagggag cgatttatcc gattttgaaa cgtatgaccg 1134421 agaagggatg gatcgaattt ttttgggaag attcactgga cggcccgaaa agaaagtatt 1134481 acaaaatgac gcaaaaagga gaagaaatgt taaaagaacg gctggagaaa tacctggaaa 1134541 cccatcaagc cttactgtct ttatcggggg atttgctatg aatggacagc ttatcattga 1134601 ccgatacatg gaggaactaa atgcagagct ggcgaatatg cctgatgtag agagagaaaa 1134661 cgctatcgac gaattaaagg ggcatatcac cgctttcgtt caagacagaa tcaaagccgg 1134721 ccttagtgaa gaggaactgc aggaagctgt tgaatctgaa ttttctcatc cgaaggagct 1134781 tgccgaattg atgatgggtg atgggggaga gacgaaaagg aggaggtctt tattgggcaa 1134841 aagctggatt tcggtccttc tcattgtcac gattatcgcc ctgccgctgc tgccgtccga 1134901 cttcagacat ctgccgctgg ctgtttattt aatggtgctc gccggatatg tatggaagcg 1134961 gaaaaaattg gtgatgtttg caggtgtcag aaaaaacaaa atgcgctctc aaaaggagat 1135021 tgtcaagatt tcgcgagtcg gtgcggttta tctgctgttt ttagcagtgg tgctcctttt 1135081 gagcccgttc ctcaatgcgc ttgtcgtcct gctgctgatt gcagtaagct gcgccgcttt 1135141 ttttcttttt cttaacatca agtaatcttg taggaggctg taagatggaa atcagcatca 1135201 attatctatt aattgtcatc gcgcttttat tctttgtggt tgcctatttt gtcggaatca 1135261 aaaaacaaac ctggatgttg gctgggttta acgaggcgcg tatacgggat aaagatcggc 1135321 tggccagaat agcaggctac tttttcttga attccggttt gttcattttg ctgaatagtt 1135381 ttatctcatt tcaaggtcag gagcagctca tacctccgct tatactggca tatggagcag 1135441 gggttattat ttatgtcaat aaaaaattag tagagtagaa aaagaagggc agagcgaaat 1135501 atctctgccc ttcttttttg ggaaaataag aacgaagcac cacatacaag tttttgtatt 1135561 tttgatagga tgaagaaaaa tggtagattc caaaatagga aggatgtggt gttttgcgca 1135621 acttgaccaa gacatctcta ttactggccg gcttatgcac agcggcccaa atggtttttg 1135681 taacacatgc ctcagctgaa gaaagcatcg aatacgacca tacgtatcaa accccttcat 1135741 acatcatcga aaagtcaccg cagaagccgg tacaaaacac aacccagaaa gaatcgctat 1135801 tttcctatct tgacaagcat caaacgcagt ttaagctcaa agggaatgcg aacagccatt 1135861 ttcgcgtttc gaaaaccata aaggatccaa agacaaaaca aacgtttttt aaattaacgg 1135921 aggtttacaa aggaattccg atttacggct ttgaacaagc ggtcgcgatg aaggaaaaca 1135981 aacaagtgaa aagtttcttt ggaaaggtgc atccgcaaat caaggacgtc tccgtcacac 1136041 cgtctatttc tgagaaaaaa gcaatacata cagcaaggcg tgagctcgag gcttccattg 1136101 gaaaaatcga atatcttgat ggggaaccaa aaggcgaatt atatatctat ccacacgacg 1136161 gtgaatatga tctcgcctac cttgtgagac tctcgacatc tgaacctgag cctggctatt 1136221 ggcattattt catcgatgcc aaaaacggaa aggtcatcga gtcctttaat gccattcatg 1136281 aagcggcagg tacaggaatc ggcgtgtcag gtgatgaaaa aagctttgac gtcacagaac 1136341 aaaatgggcg cttttatttg gctgacgaaa caaggggaaa agggatcaat acatttgacg 1136401 cgaagaacct gaacgaaacc ttgtttacgc ttttgtctca actgatcggg tatacgggca 1136461 aagaaatagt cagcggcacg tccgtattta atgaacctgc ggctgtagac gcacacgcaa 1136521 atgcgcaagc cgtttacgat tattacagca agacatttgg ccgtgattct tttgatcaaa 1136581 acggagcaag gattacgtct accgtgcatg tcggcaaaca atggaacaat gctgcgtgga 1136641 acggtgtcca gatggtatac ggggatggag acggttcgaa atttaagccg ctgtctggat 1136701 cgctcgacat tgtcgcgcat gaaatcacac acgcagtcac acagtattcc gccggtcttt 1136761 tatatcaagg agaacccggt gcattaaatg agtccatttc tgacattatg ggcgcgatgg 1136821 ctgaccgtga tgattgggag atcggcgaag atgtctatac tcctggtatt gcaggagatt 1136881 cattgcggtc attggaggac ccatctaagc agggaaatcc agatcattac tcgaaccgct 1136941 acacaggaac agaggattat ggcggagtcc atatcaattc gtccattcac aataaagcag 1137001 cttatcttct tgcagaagga ggcgtgcacc acggtgtaca ggttgaaggg attgggcgtg 1137061 aagcaagtga acaaatttac tatcgggctt taacatatta tgtaacggca tctacagatt 1137121 tcagcatgat gaagcaagcg gcgattgaag ctgccaatga tttatacggt gaaggctcga 1137181 agcaatcagc ttcagtcgaa aaggcgtatg aggctgtcgg cattctatga gcaaacaaaa 1137241 acagtcagga cacagagtct gactgttttt gtttgctcat tttcttaaaa agaatatcgc 1137301 caatgtacct ggaccggcat gcgagccgat ggctgaactg attggatgca taatgatttc 1137361 tttcggcttg aacgcttcct caatcaggtg tttcatatcc gtggcttttt ctttgttcgc 1137421 ggcgtagcta atcccgacgg tttgattgct ccaatcatcc ccgcgctctt tcataagctc 1137481 gatgatccgt ttgaaaagtt tcttctgtcc gcgaattttt tccagaggca caagcttgcc 1137541 gtcctccatc tgaagcagcg gtttaatatt caacaggccg ccgacaaaag cggacgtttt 1137601 ggatatccgg ccgcccctcg cgagatatgt taaatcatca acggtaaaaa tgtgttcaag 1137661 ctggctgcaa aagttcttta cagacgtttc aatttcttgt attgtattcc cgttgataca 1137721 gagatcggca gcatgccgga cagccagacc gtatcctaat gaagcgcatt tggaatcaat 1137781 gacccgcaaa tcgaaatcgg ggaattcctc cttcacttca ttggcgatca ttacagctgt 1137841 ctgatacgtg ccggagagac ctgaggaaaa ggcaatgtaa agagcgggat cacctgtttc 1137901 ggcatattgc aaaaacacat ttttaatcgt ttgcggtgag gcttgggacg tcttaggcgt 1137961 ttctccattt tgcatcgctt caaatatttg atccgcatga attgtgactg catcttcgaa 1138021 ttctttatcg ccgagagaaa ccctgagcgg aataaagcca atgccttttt cttcaaaata 1138081 agaacgaggc aaatcagtgg cgctgtcagc gatgagatga actgtcatat tgcttccctt 1138141 ctttccgtta tcgctcgtta tcatgagagt taagccaact atatcatatt aatttgccaa 1138201 aatcgtgttc aaatatttgt tttaagggaa aacataataa agaagaaaga gcggaggaac 1138261 atgccatggt actagatcaa acaaaaaaat tactcatcgt catcatcggc gctttactca 1138321 atgctgccgg gctgaactta tttttgatac ctgcagatgt atatgccagc ggatttacag 1138381 gtgttgccca gcttttatca agcgtcgttg atcaatatgc ccccttttac atatcgacgg 1138441 gaacgctctt gttcctctta aacattccgg tcggtatttt aggatggctg aaggtcggca 1138501 aatcgtttac agtgtacagc attttaagtg tcgcactcac tactctgttt atggggatcc 1138561 tgccggaaac aagcctgtca catgacattt tgctgaacgc ggtgttcggc ggcgtcattt 1138621 ccgcagtcgg tatcggctta acattaaaat acggagcttc gacaggcggg cttgatatcg 1138681 tcgccatggt acttgcaaag tggaaggata aacccgtcgg cacgtatttc ttcattctga 1138741 acgggattat catcttgacg gcaggattat tgcaaggttg ggagaaagca ttatataccc 1138801 tggttacact atatgtgaca acgagggtga tcgacgccat tcacactcgc cacatgaagc 1138861 ttacggcaat gattgtgacg aaaaaagcgg acgaaatcaa ggaagccatt tacggaaaaa 1138921 tggtgcgcgg catcacaact gttccggcaa aaggagcatt tacgaacgaa cagaaagaaa 1138981 tgatgattat cgtcatcacg aggtatgaac tgtacgattt agaaaagatc gtcaaagaag 1139041 ttgatccaaa agcatttacg aacatcgttc aaacgacagg gatttttggt ttctttagaa 1139101 aagactgacg aaagcaggtg gaagtcgtga aacggctgct tgtgatgctc ctccccgtgc 1139161 tgcttttgat aggctgcggg aaagatgagc agacagaacc cgataaggag gtatcaggcg 1139221 gaatggagaa tcaagaggtt gttttatcta ttgacgcaat tcaggagcct gaacaaatca 1139281 agtttaacat gtcgctgaag aaccaaagcg aacgtgctat tgagtttcaa ttcagcacag 1139341 ggcaaaaatt tgaacttgtc gtgtatgatt ctgagcacaa agaaagatac cgttattcga 1139401 aagaaaaaat gtttacgcag gcttttcaaa acctgacgct tgaatctgga gaaacatatg 1139461 atttctctga tgtgtggaag gaagtccctg agcccggaac ctatgaggta aaggtgacat 1139521 ttaagggcag ggcggaaaat ctcaagcagg ttcaggctgt tcagcagttt gaagtcaaat 1139581 aagaggctat ggcgagtcgc catagccttt ttttattgca gtttgtccag ctgattttga 1139641 aattgatgca actgttgacg ttccgcatct gtcgaattgg catacgcaga agatacagca 1139701 tttttggctc tcagaatcgc ttgctcctga tcgccttcct caaagccgtt tgtcaccatg 1139761 accgcctgtt gaacaaatga ttttgcctgc tgaaacagtt catttctcat ttaatattca 1139821 tactgccttt cagccgagtc tcgtgccgcg gcatgctggt gagcttcttc taaagtagac 1139881 cgatatggaa atcttgcggc gtgtagcccg atggagtctt taccctgctg aataaacctt 1139941 ctggatttgc ttcgtttacc cattttgaga ctgccccctt ccatactttg acgagatgag 1140001 tcgtcttcaa tagtatggtg gggtaaagta aggtttatga gtgggaaaaa ttaatacgga 1140061 ccttctttaa agtgagaaat attctttcaa aaaccttgcc acgccgtcct cttcatttgt 1140121 ggccgtagtt cggttggcaa tctgcttgac cgcgtcaatt ccatttccca ttgcaacgcc 1140181 gcagcctgca aattcaagca tttccaaatc gttatcctca tctccaaaag caatgatccg 1140241 ctccctcggc acgccgtaat aatcgctgat tttctgcagg ccgaccgctt tattcatgcc 1140301 gcttttgata atttcaatga catgccaagg agcggcccat cttctatggt cgatcacctc 1140361 ggcatgcaca tccgataaat atgagcgtat tgccggcaca tcctcttcct ttgcatgtat 1140421 gagtacggac gtcacatctt caccgagatt ttcccgcaag tctccgaccg ttacatttgt 1140481 tgtgttcatg ttaaaggcat ctatcaggtg ctcatcatgg taatgaaagt atacgtcgtc 1140541 aatcacttca gcaagcacgt tatgtacgtt gtagctctcg ctgatatcca cgagctgttt 1140601 gacaacatca agcggcagtg acgtatgata ccgtccccag ctgtcgtctt gcggatgatg 1140661 gacaaatgct ccgttaaaat tgacaattgg cgttgtcagc tccatctgct ggtagtacat 1140721 ggaacttgaa cgatacggac ggcctgttga gatgcagaca taatgcccgt catcttttag 1140781 gcgctgtatc gtatgaaggg tgttttcaga tatggtttta tcatccttta ataatgttcc 1140841 atctaaatct aatgcgatta aatagggttt tgtctccatg aaaagctcct ttaaccttag 1140901 attttgcttg ttttgcctta cttacagtgt agctttttac catctttatt gtctacatgt 1140961 tacacttatg attatggtta tcctaaggag gggcacattg tgatacaaat tgagaatcaa 1141021 accgtttccg gtattccgtt tttacatatt gtaaaggaag agaacaggca ccgcgctgtt 1141081 cctctcgtga tctttataca tggttttaca agcgcgaagg aacacaacct tcatattgct 1141141 tatctgcttg cggagaaggg ttttagagcc gttctgccgg aggctttgca ccatggggaa 1141201 cggggagaag aaatggctgt tgaagagctg gcggggcatt tttgggatat cgtcctcaac 1141261 gagattgaag agatcggcgt acttaaaaac cattttgaaa aagagggcct gatagacggc 1141321 ggccgcatcg gtctcgcagg cacgtcaatg ggcggcatca caacgcttgg cgctttgact 1141381 gcatatgatt ggataaaagc cggcgtcagc ctgatgggaa gcccgaatta cgtggagctg 1141441 tttcagcagc agattgacca tattcaatct cagggcattg aaatcgatgt gccggaagag 1141501 aaggtacagc agctgatgaa acgtctcgag ttgcgggatc tcagccttca gccggagaaa 1141561 ctgcaacagc gcccgctttt attttggcac ggcgcaaaag ataaagttgt gccttacgcg 1141621 ccgacccgga aattttatga cacgattaaa tcccattaca gcgagcagcc ggaacgcctg 1141681 caatttatcg gagatgaaaa cgctgaccat aaagtcccgc gggcagctgt gttaaaaacg 1141741 attgaatggt ttgaaacgta cttataaagc actaagttat taacaagagc tgaatttacg 1141801 ttatactgta gaaaaaagga gtgagggaac gtggaagaag cattaaaaga aaacatcatg 1141861 ggcgccctgg aacaggttgt cgatcctgag cttggcgttg atatcgtgaa cctcggcttg 1141921 gtatatgacg ttgatatgga tgaagatggc ttgacgcaca tcaccatgac gctaacatca 1141981 atgggatgcc ctttagcgcc gattatcgtg gatgaggtga aaaaagcatt agcggacctt 1142041 cctgaagtga aagacacaga ggttcacatt gtatggaatc cgccttggac tagggataaa 1142101 atgtccagat acgcaaaaat tgcgcttggc attcaataaa acaaaaaagg acagcctgac 1142161 atgtgaggct gtcctttttt acagctgaaa ggagtgaaag gaaatgatgt acctgctggc 1142221 agttttatgc ccgccgcttg ctgttttgtt ttcgggaaaa ccgtttcagg ccttgctgaa 1142281 tctcatattg acctgtatct tttggctgcc gggcgcgatt cacgcctgct ttatcgtcgc 1142341 cgaccgccgt gccgaaaaac gggcaagaag ataatttgga aaaatgagga cgcagtcatg 1142401 gtataatggt cataaaaaca gcagggagag cactatgaaa aagaaattgc ttgcattcgc 1142461 gctttgtact ggcgcgtatg cggccctgtt tgcgtactct gtgaactcag agcaaaaaac 1142521 agccacaagc gagatgacgg atgtcagccg cctgatgcct gtaaaaataa agcagacagt 1142581 gaaagggcag gaagaggaaa tgctcattga cacagtcaaa gaggcaaatc gaaaaaacat 1142641 aaaaatttca atcgccgggg cccagcactc catgggcggc catacatatt atgaggacgg 1142701 catcgttctc gacatgacgg gctacaacaa aatcctgtca ctcgatcaag agaagaaaac 1142761 catcagggtg caaagcggtg caacgtggaa tgatatccag aaatacgtga atccatacgg 1142821 actcgcggta aaagtcatgc agtcacaaaa catttttaca atcggcggat ctctcagcgc 1142881 aaatgcacac ggacgtgata ttcgctacgg ctcgctaatt gatacagtca aatcattccg 1142941 gcttttaaaa gctgacggga tgattatcac tgtcactcca aaagatgatt tgtttacggc 1143001 ggtcatcgga gggtacggcc tttttggcgt gattcttgat gtaacgcttg agctgacaga 1143061 tgatgagctg tatgtcatga agacagaaaa aatgaattac agcacatact cagactattt 1143121 ttcaaagcat gtaaaaggaa atccagatgt ccgaatgcat ctggcgcgaa tttcaacagc 1143181 gaaaaaagga tttctgaaag acatgtatgt cacgaattac gtattggcta atcatcagga 1143241 tcagctgtcc tcatacagcg aacttaaaga agacgagtat acgggagcca caaagtttgc 1143301 actcggcttg tcaagacggt atgaatgggg gaggaattgg ctgtgggaca cacagcaatc 1143361 ctatttcctg agccagaacg gcacagagat ttcacgcaat aacgtcatgc ggtccgaatc 1143421 aaagtttctt gagtatgaaa acaatgacaa cacagatgtt ttgcaagaat actttgtgcc 1143481 cgtgaaggag tatgggtcct atattgatga cctgagacaa acgctgtcgg acgaagatct 1143541 gaacctgctg aacattacga tccgctacgt gcagaaaaat gaaaaggccg acctttccta 1143601 tgcgaaggac gatatgtttt cgctcgtact attaataaac gagggctttt caaaagaaga 1143661 ccaggcagat accgcccgaa tcatcaggcg catgacagac gttgccatca agcacggcgg 1143721 cagctattat ctgccttata tgacctacca gacaaaagcg caaatgagac aggcatatcc 1143781 gaaaagtgaa gcgttttttc agaaaaaacg aacctatgac ccggatgagc gctttatgaa 1143841 ttacttttat cagaggtata aataatgggg aaaaacaaat taaaatggct gacattatca 1143901 caaagcagcg tgtttttcgc aagcagctta atctttccgt tttatattct gtttgtgaaa 1143961 aatatcggct caagctacac acagttcggt ttttcctacg gattgttcgg gttgagcgga 1144021 gcgcttattt acccgctcct cggacggctg tctgaaaggt ttgacagccg ttattttctg 1144081 cttctgaact cgtgggggat ggctgttctg cttttatatg tcccgcatat cggaagcgtc 1144141 gttcaagtgt atatcgtcca agtgctgtta gggctctttg gagcgatgca aaagcatgga 1144201 gaaaaagtgc tgatcgctaa ttttacagac agtggagagc gtggaaagaa gatcgggaat 1144261 taccattttt ggacagctgt cttttcagca gcagccatta tgctcggggg ctttctcgct 1144321 gactttttca cagtgcaaat gattttttat gcaagctcta ttctatattt tttgagtgga 1144381 ttgatgatga tgaaaacagg ctgacgcggt cagcctgttt ttttatgcgg ctgaaatgcg 1144441 gcaccgcatc aacgtttttg tgctggagtc gtgctgattt tttttgagcg gaattcccat 1144501 tgaacagaaa atttataaat gaataaaaat attaaatata cgattgaatt aatttttatt 1144561 catgttataa tgttaaataa tttcacaaag accaagaggg tgaacttgtt ttgaaaatag 1144621 gaattgtagg tgctacagga tatggaggca ccgaacttgt caggattctt tcgcatcatc 1144681 ctcatgcaga ggaatgcata ctttattcat ccagcggaga agggaatgtc tatagcgagg 1144741 gttatcctca tcttaccggc ttagcggatc agcagctgaa gccgattgat atgaatacga 1144801 tcaaacacga aatagatatc atgtttctcg ctgcgccgcc cggagtatca agtgaattga 1144861 ctccaaagct ggcagacgcg ggaattacgg ttattgatct gtcaggtgat ctgaggataa 1144921 aagaaccggc tgaatatgaa aaatggtata aacggacagc ggcaccgaag gcggtgattc 1144981 aagaggcggt atacggtctg gcagaactga atcaactgca aattcaacag gcgaaactca 1145041 ttgccaatcc aggctgtttt ccaacagctg ttttgcttgg cctcgcgcca ttggctcaaa 1145101 agaaactgct cgatgaatct ttcgttatcg ttgacgcgaa gaccggtgtt tccggagcgg 1145161 gaagaaaagc atccatggga actcattttt ctgagctgaa cgacaatttt aaaatttata 1145221 aagtcaatga acatcagcac acgccggaaa ttgagcaggc gctgaatgaa tggcagccag 1145281 gtctcgggcc cattacattt tcggctcact tggttccgat gacaaggggc atcatggcga 1145341 cgatgtatac cagattaacc tgtgacctaa ccgcagatga cctgcatgat ttatattcgg 1145401 aattttacca agattcatat tttgtgagag tgaggccaaa aggtcagtac ccgcaaacga 1145461 aagaagtgta cggcagcaat ttctgtgata tcgccgtgac cctcgatgag agaacgaaca 1145521 gagtcacgat cgtctcggta atcgataatt taatgaaggg tgccgccggt caggcagtgc 1145581 aaaactttaa tttgatgaat ggctggaatg aagaaactgg actcaccatc acgccaattt 1145641 atccatagaa cgggagagaa tcgaaccatg attcagttaa gtgaagatca aattgtaaaa 1145701 gtaacaggtg atgtatcctc gccaaaaggg tttcaggcaa agggtgtgca ttgcggactg 1145761 cgctactcga aaaaagacct cggcgtcatt atcagcgaga caccggccgt gagtgcagca 1145821 gtttataccc aaagccactt tcaggctgct ccgatcaaag tgacacaaga cagcttaaag 1145881 cacggaccga cactgaaagc cgtcatcgtc aacagcgcca ttgccaacgc ctgcacggga 1145941 gaacagggct taaaggacgc atacacaatg cgggagagct ttgcttcaca gcttggcatt 1146001 gagccggagc ttgtcgctgt ttcatcaacg ggtgtcatcg gcgagcattt agacatggaa 1146061 aaaatccacg cggggatcga actgctgaaa gaaacacctg cgggatcagg cgattttgag 1146121 gaagcgattt taacaactga tacggtgatc aagcagacgt gctatgaact ggcaatcggc 1146181 ggcaaaacag tcacgatcgg cggagcggcc aaaggctctg ggatgataca cccgaacatg 1146241 gccacgatgc tgggatttgt gacaactgac gcggcaatcg aagaaaaagc gctgcaaaag 1146301 gcgcttcggg aaatcactga cgtttcattt aaccaaatca cagttgacgg agaaacatcc 1146361 acgaacgaca tggtattagt tatggcgaat ggctgcgccg aaaacgagtg cctgacagaa 1146421 gaccatccag actggccggt ctttaaaaaa gcgctcttgc tcacttgtga ggatctagct 1146481 aaagagattg ccagagacgg agaaggcgcg acaaaactaa ttgaagccca agtacaggga 1146541 gcgaaaaaca atcttgatgc aaacgtcatt gccaaaaaga ttgtcggctc aaatcttgta 1146601 aaaacggcag tatacggaac agatgccaac tgggggcgga tcatcggagc catcggacac 1146661 tccgcagcac aggtgacggc agaagaagta gaggtttatc ttggcggcca atgcctgttt 1146721 aagaataacg aacctcagcc attctctgaa tctatcgcca aggaatacct tgaaggagat 1146781 gaaatcacca ttgtcatcaa gatggctgaa ggggacggaa acgggagagc gtggggctgt 1146841 gacctgacct atgactatat caaaattaac gcgagctatc gcacgtaata aaggggagcg 1146901 aaatgaagaa aacaatcgtt tttaaatgcg ggggaagcgt catccgtgag ctgtcggagg 1146961 aattttatca aaatctgaaa gagctgaggg cgtcaggctg gaagctggca atcgtacatg 1147021 gcgggggacc ggaaatcaca aatatgctga aacggttaaa tatcaagaca gagttttcgg 1147081 gcggacagag gaaaacaacg aagccggtgc tggaagtggc ggaaatggtt ttatccggtt 1147141 ctgtcaataa atttttcgtt gctgagcttg ccaaacacgg actgcgagcc gcgggcattt 1147201 ctggtaagga tggcggtctt ttggaggctg attatctaga tccggaaaca tacggagaag 1147261 tgggagaaat caaaaaagtc gatgcgtcca tggtgaacgc gctgatggaa aatggcatca 1147321 tccccgttat tgcgccgctg tctatgacaa gcgactgcaa aacgctgaat gtaaatgctg 1147381 atctggctgc ttcagcagtc gccggagcgc ttgaagccga taagctgatg ttcgtcacgg 1147441 atgtcgatgg aatcatgaag gaaaagcagc gtctggacgt cctgacccct aaggagattc 1147501 agatgctgat caagcaggaa gtgatcacag gagggatgat cccgaaggtc aattcagcct 1147561 tgtcagcttt atcagatcag gtgtctgaag tcatgatcgt aaacggtaaa ggatcattct 1147621 tcgcagaaca aacctttcaa gggacaaaaa ttgtcaaagc aaaggaggct gtttcatgag 1147681 cagcttgttt caaacctacg gccgttggga tattgacatc aaaaaagcaa agggaacgta 1147741 cgttgaggat caaaacggca aaacgtacct tgatttcatt caggggattg cggtatcaaa 1147801 tctaggacac tgccatgaag cggtgacaga ggcagtcaaa aaacagcttg acagcgtatg 1147861 gcacgtatcc aacctgtttc aaaacagtct ccaagagcaa gcggcgcaga agctggcagc 1147921 gcatagtgcg ggagatcttg tctttttctg caacagcggc gcggaggcga atgaaggtgc 1147981 gataaagctt gccagaaaag caactggaaa aacaaaaatc atcacttttc ttcagtcgtt 1148041 ccatggccgc acgtatgcag ggatggctgc gaccggacag gataaaatca aaacaggctt 1148101 cggcccgatg cttggaggct ttcactacct gccatacaat gatccttctg cttttaaagc 1148161 tcttggggag gaaggcgata ttgccgcggt gatgcttgaa acagtgcagg gagaaggagg 1148221 agtcaatccg gcgagtgctg aatttttatc agccgtacag tcgttttgca aggaaaagca 1148281 agcccttctc attattgatg aaatccagac cggcatcgga cggacgggaa aaggcttcgc 1148341 atatgagcac ttcggactct caccggatat catcacagtc gccaaaggat tgggaaacgg 1148401 ctttccggtc ggcgctgtca tcggaaagaa acagcttgga gaagcgttta cccctggttc 1148461 tcacggaacg actttcggag gaaacatgct ggcgatggct gctgtgaatg ccacattgca 1148521 aattgtattc cagcctgact ttttgcaaga ggctgctgac aaaggggcgt ttttaaaaga 1148581 acagcttgag gcagagctaa agagcccttt tgttaaacaa atccgaggta aaggattaat 1148641 gcttggaatt gagtgtgatg gcccggttgc tgacattatt gctgaattgc agacattagg 1148701 cttgcttgta ttgccggccg gcccgaacgt gattcggctg ctgccgccgc tcaccgtgac 1148761 taaggatgaa atagcagaag ccgtcagcaa gctgaaacag gcaatcgctc atcattccgc 1148821 tgtaaaccag tgattttttt tcgatataaa ggcataaaaa ttcattttta taattaatta 1148881 ttcatcaaga ggtgggctgt tagatggaag gttatttagt gttagaagat gggacatcgt 1148941 tcagcggcga gctggacggt catgaaaact gcacgggaga agctgttttt ttcacaggaa 1149001 tgacaggcta ccaggaagtg ctgacagatc catcatataa gggacagatt attgtattta 1149061 cctacccgct gattggcaac tacggcataa atgaaaagga ttttgaaagc aagaaaccgc 1149121 aagtaaaagc cgcggttgtc tatgaggcgt gtgatcactt ttctcattat gaagcggtat 1149181 acagcctcaa ggagtatcta cagaaatgga atattccgct gttaacccat gttgatacga 1149241 gggctgtcgt gaagaaaatc cgggcaaacg ggacgatggg tgcgacagtc acagcctcta 1149301 aagaaggagc tgagattgcc cttcaaccag agaatgtggc agagcaggct tccgcccagg 1149361 aaatcagcac attcggcgac gggaataaac atatcgctct cattgatttt ggctataaaa 1149421 agtcaatcgc atcatcactt gtcaaacgag gctgcaaggt taccgtggtg ccataccagc 1149481 aaatggaggc cgtatacaac atcaaacccg atgggctatc gaacggacct ggagatccga 1149541 aagccattca gccatattta ggaaagatca aaagcatcat cagccgcttt ccgactctag 1149601 gcatttgtct cggacatcag ctgatcgcgc tcgcgtttgg agggaatact tttaagctgc 1149661 cattcgggca caggggagct aatcatccgg tcatcgaccg taagacgaaa cgggtcttta 1149721 tgacaagcca aaaccacagc tatgtggttg atgaacagtc gattaatgaa gaagagctca 1149781 ccatcaggtt tcatcatgtc aatgatacgt cagttgaagg gcttgcccat aaaaaactgc 1149841 ctgtcatgag tgttcaattc cacccggaag cccatcccgg acctgcggaa agcgaatgga 1149901 tttttgatga ttatctaaag aatgtgatac cagcaaggag agaaatcgcg catgcctaaa 1149961 gacaccagta tttcaagcat attagtaatt ggctcaggcc cgatcatcat cgggcaggcg 1150021 gcagaatttg attattcagg cactcaaggg tgcatcgcgc tgaaggagga gggctaccgg 1150081 gtaattctcg tcaacagcaa tccggcgaca attatgactg atgaagcctt cgctgatgaa 1150141 atttattttg agcctctgac agcagaaagc ctgacagcca tcattaagaa agaacggcct 1150201 gatgggcttc ttgccaattt aggcggtcag accgcgttga atttagcggt ggagcttgaa 1150261 gaaacgggtg ttttaaaaga gcacggcgtc aaactcctcg gcacatccgt tgaaacgata 1150321 caaaaaggag aggaccggga aaaattccgt tcgttaatga atgaattaaa acagcctgtg 1150381 ccggagagtg aaattgttga taacgaggcc gatgccctcc attttgcgga atccatcggt 1150441 tttcctgtta ttatcagacc agcttacaca ttaggcggaa agggcggagg aatcgcccct 1150501 gataaagaag cctttacagc tatgattaag caggcgctat tagcaagccc gatcaatcaa 1150561 tgccttgtcg aaaaaagcat tgccggcttt aaagaaattg aatatgaagt catgcgtgac 1150621 agcaataaca catgcattac cgtctgcaat atggaaaata tcgatccggt cggcgtgcat 1150681 acaggtgact ctatcgttgt ggcgccgtca caaacattga cagacgaaga ctatcaaatg 1150741 ctgcggacag caagtctgac gatcatctca gcacttgatg ttgtaggcgg ctgcaacatt 1150801 caattcgcgc ttgatccatt cagcaagcaa tattacgtca ttgaagtgaa tccgcgtgta 1150861 agccggtcat cggctctcgc atctaaagcg accggttatc cgattgcgaa gatggccgcg 1150921 aaactggcag tcggatacac tcttgacgag ctgaaaaatc cgctcacagg ctcgacttac 1150981 gcaagctttg aaccggcact ggattatgtg atcgtcaaat ttccgcgctg gccgtttgat 1151041 aaattcaaaa acgcagaccg caagcttggc acaaaaatga aagccaccgg tgaagtgatg 1151101 gcgattgaac ggaatttaga agcggcgata caaaaggcag ccgcgtcgct tgaattaaaa 1151161 aatatcggga cacaccttcc agagctcagc gggttgtcaa ttgatacgct atgggatttg 1151221 gcaatcactc cggatgaccg cagatttttc gttgtcatgg agctgttgag ccgcagcgtc 1151281 tcgattgatg acatccatga aaaaacaaaa attgatccgt ttttccttca tacctttgac 1151341 aacatcatca aattggaaaa ccgcctgatg gaagcaggga gcgatctctc ttttgaatta 1151401 ttgaagaaag caaaggaaaa gggattctca gacgcaacga ttgcctcgct gatcagcaaa 1151461 acagaagaag aggtgcgcgc gcttcgcaag gagatgggca ttacgccttc ctttaaaatc 1151521 gtagatacat gcgcggcaga gtttgatgcg aaaacaaact atttttactc cacatatttc 1151581 ggagagaccg atggagacat cagccgcaaa gagaaaaaac gcgcgctcat tatcggatca 1151641 ggcccgattc ggatcggcca aggcgttgaa tttgattaca gtgctgttca cggtgtgctg 1151701 acactgcaag agcttgggtt cgaaaccatc atgattaaca ataacccgga aactgtcagc 1151761 accgattatg aaattgcgga ccgcctgtat tttgaaccga tgacaacgga gcatattgta 1151821 aacgtggcgg agcaggaaaa tattgatttt gcaattgtgc aatttggcgg tcaaactgca 1151881 atcaatgctg ctgaagcgct cgaaaaagcc ggcattactc ttcttggcac atcatttcaa 1151941 acgctcgacg tgttagagga tcgggatcaa ttttatcagc ttcttgacga gctgggattg 1152001 aagcacgcaa aaggagaaat tgcttataca aaagaagaag ccgcttcaaa agcgagtgag 1152061 atcggctatc cggtgttaat ccgcccatct tacgttatcg gcggaatggg catgatcatt 1152121 gttgactcgc aagcccagct ttctcagctg ctgaatgatg aggacagcat gccatacccg 1152181 attttaattg atcagtatgt gtctggaaag gaagtcgaaa ttgatttgat ttccgacggc 1152241 gaggaagtct ttatcccgac atataccgag catattgaac gggcaggtgt ccattcaggg 1152301 gacagttttg ccattcttcc cggaccgtcc atcacgagcg ggctgcagca gggcatgaaa 1152361 gatgcggcac aaaaaattgc ccgaaaactt tcatttaaag gcatcatgaa cattcaattt 1152421 gtgatcgaca atggaaacat actcgttctt gaagtgaatc cgagagcgag ccgcacggtt 1152481 cctgtcgtca gcaaagtaat gggcgttccg atgattccgc tcgccacacg tctgctggcg 1152541 ggagcgtcct taaaagatct aaatccggca gttcaaaatc atcatggagt tgccgtgaag 1152601 ttccctgttt tttcttctca tgcgatccag gatgtggatg tcaagcttgg accggaaatg 1152661 aaatcaacgg gagaaggcat gtgtgtcgca tatgattcta acagcgcctt gaaaaaaatc 1152721 tatacaagag tctggagtca aaaaggaagc atttatttgc aaaacgttcc ggaagatgtg 1152781 aaggagttag cagaaaacgc aggttttaca atacatgaag gaacatttgc ctcatggatg 1152841 gaacaggaag gaaactcgct ccacattaat ctgagcggtt ctgaagaagc acgcaaagaa 1152901 cgtttggaag ccatgacgca cggcatcccc gtctttacag aagaagaaac tgtgcgggcg 1152961 tttttacaaa gcggttcagg ccatccgcag cctgtatctc tcaaagacct ctataaaaag 1153021 gaagtggcat catgcacaca gtgacgcaaa ccagtttata cggaaaagat ttattaacgt 1153081 taaaggacct tagtgaagaa gatataaacg ccttgctcgc agaagccggt gagctgaaac 1153141 aaaacaaaat tcagcctata ttccatggca aaaccttggc gatgattttt gaaaaatcat 1153201 caacgcggac ccgtgtttca tttgaagcgg gcatggcgca gctgggcggg agcgccctct 1153261 ttctaagcca gaaagatctg cagctggggc gcggtgagac tgtcgctgat acggcaaaag 1153321 tgctgtcagg ctatgtggat gccatcatga tccggacctt tgaacatgaa aaggtggagg 1153381 aacttgccaa agaagctgac attccggtga tcaatggact taccgataaa taccacccat 1153441 gccaggcgct ggcggatctc ttgacgatta aggagataaa agggaagctt aaaggcgtaa 1153501 aagtcgcgta catcggtgac ggaaataacg tggcgcactc cttgatgatc ggctgcgcga 1153561 aaatgggctg tgatatctcg atcgcttcac caaagggata tgaagtgtta gatgaagcag 1153621 ctgaagcggc aaagacatat gcacttcaat ccggctcttc tgtcacgctg acagatgatc 1153681 cgattgaagc tgtaaaagac gcggacgtga tttattctga tgtgtttaca agcatggggc 1153741 aggaagcgga agagcaagaa cgtcttgctg tctttgcgcc ttatcaggtg aatgcggcgc 1153801 tggtcagcca tgccaagcct gactatacat ttttacattg tctccctgcg catcgcgagg 1153861 aagaagtgac tgcggagatt attgacgggc cgaactctgc agtgttccag caggcggaaa 1153921 accgtcttca tgtgcaaaaa gcactgctga aggccatttt atataaaggg gaatcatcaa 1153981 aaaactgctg agccaaactc agcagttttt ttgatggcaa catattcaca gccgcttagg 1154041 cgcatactac agcaaaaagg aaaaggagga aaaacagtgg gacagcagca ccaattccgg 1154101 cccggacaga aagcgcctaa taacggtgtc tacgtagaaa tcggcgagac agggagcatg 1154161 gttaaaaacc ctcaaaaggt ccatctgtca gcaggggaaa tgttccccga aacatcaaac 1154221 cacaaccggc tgtggaccta caaaagaaag ccgtgaccac taaaaaaccc aaaacaataa 1154281 atgttttggg tttttggctt tttaatgctg gcttgcattt ttgttcatag gcatgatttc 1154341 tgctaaaacc atgattaaga catacagtac aacagcaatg acagatgatg ttttgaaatt 1154401 atacgtaacg ctgttcatgc ttgcaaccaa gtagcatgcc atatgtgata aaaggaacgt 1154461 ccaaataaag gcaataatat atcgcacgtt tccacctcgt ccttctcatt ctattctaaa 1154521 agttatcata ccatacaaaa agcgaagggg gaatccaatt ttagcagaaa gtgaggtgac 1154581 aaaagagtct gattcgtcac actttaatgg taaaatataa aacgtcaatc agtataatag 1154641 ccaaaaatgt aaaaggctag gactttacct tattcgtttc ttttctattt acataagata 1154701 gcgtgagatg aagtgtgaaa ggaggcgggc aagcgatggg aataacggaa agatactttc 1154761 aactgggaac ggagcataat gtcattcatc tgccctatcg cccgaacggc ttcggcatct 1154821 ttatcttggg ggacagaacc cactttgtcg gacatgattc aagcttttgg cagcagcatt 1154881 atggcagaaa tcagcttctg agcatgttga tgaatgaagg atacactctt tttaacagca 1154941 atctgttcgg aaggcattgg ggggcggaaa aagcagtcac ctatgccaaa cagctgatac 1155001 attctgtgct gaagcaggaa atcctcaatc cgaagattca tattttagca gaaggcatgg 1155061 gtgctctcgt ggccgatgaa ctgcttcgtt tttccccgga tcatatccgc tcagccgcaa 1155121 tgttgaatcc ttgtctcgat cttcaggcac attatgaatc ggaaaaagaa aataaatttt 1155181 tctataagca atttttgaaa gaagtatcga aaagctacgg aatttctgaa aaagaagcgg 1155241 aagcgattcg ttataaaaca attcaaagct acccgagcgg cgtaccggtt catatatggc 1155301 agcgtatgac cggagctcca tatccctaca gcgtacatgc ggaagttttc aaggaaaaac 1155361 agcaaaagca aggctcaccg gtcgacatga catttcattt atttgagcat ccaagcagaa 1155421 tttatgcatc aatttgcaaa ttctttcata gtcatgaaaa agaattatag agaatataat 1155481 gacaacagcc ttctcttttg cggaggctgt tttgttttgg gaaatgaaaa accggaaggg 1155541 cggcagatgc aatggaatca acgctgattg taggtgcgga cgaatttttc ggcctttcat 1155601 tatgtgagcg aatgatggat gaaggcatac atgttgacgt tgttctggcg gaaacagaag 1155661 ataaaatgag acaaatgtac ttagaagaaa gactcatgtg gcttgggaga aatgaactct 1155721 ttcgccagct tgaacacatt ggagaccaaa attatgatac aatttgtatc cagttcggaa 1155781 gttttttgcc tttagaccaa tatgattctc cttatatttt agtatatgaa gaagaccgaa 1155841 aagaatggga taaacgtgaa aaaacaggct cggaaaaaac cgtgatcctg ccgaaaatgt 1155901 acgggccatg gaaagaagaa acagaggaag acggctatta cacaaacgac gtggctgacg 1155961 agttgctgag attcctgtta gaaccaagcc gtcatagcaa agatcagctt tttgaattgc 1156021 aagtcacaga gaaaacctca aaagaagaag caaaaacaaa aattatcgag tggaaaagac 1156081 aattttcatc aattttcgac aaatattaag aaaaaccttc catgtttcga gttttctaga 1156141 tacaataaac gtataaaaat aatacatgtt atagcttgtc aaaaggagtt gaacatgact 1156201 tgatcacaag gcttgtcatg atcttttctg tcctcctttt attgagtgga tgtggacaaa 1156261 ctccgttcaa aggaaaaatt gagaaggtcg gcatgctctt tcctgatacg attaatgacc 1156321 tcgtatgggg cacaaaaggg tataaaggat tactgaatat acaatccaaa tacaatgtgg 1156381 acgtctatta taaagaaggc gttaaaacag aagaagatat cataaatgcg attgaggatt 1156441 ttcataagag gggcgtcaat ctgctctacg gccatgggag tgaatatgct gaggtgttta 1156501 acttggtcgg cgaagattat ccagatatgg aattcgtcat ttccaatgcg aaagcgaaag 1156561 ctgataatgt aacaagtgtc cattttagcg gggaagcaat gggctttttt ggaggaatga 1156621 ctgctgccca tatgtcgaaa acgaatcagg tcggtgtaat tgcttccttt acgtggcagc 1156681 ctgaggttga cggttttatc aaaggggcca agtatgaaaa tccggatata gaggtaaata 1156741 cgaaatatac ggatcattgg gatgatgata caacagcagt aaagctttat cagaaaatga 1156801 agaacgaagg cgcggatgtt gtgtatcccg ccggagacgg gtataatgtt cctgttattc 1156861 agcaaatcaa aaaagacggt ctttatgcca taggctacgt cacagatcaa tcggatctgg 1156921 gcgagaatac cgtattaacc agcacggtgc aaaatgtgga caaggcctat gaaatcattg 1156981 ctgaacaatt taataaaggc acccttgagg gcggcgatca ttactacgac ctgaacacgg 1157041 gagtcgttga gatgggaaca ttcagcccgc tcgtcgatca agactttcag caaagaatcg 1157101 ccaagctgat caaaacatac aacaaaacag gcgagctgcc aaaaaacgag taatggagtg 1157161 acgtcacatg cagcacgaaa aatcacttga attcttgcaa attgccatga aatatctccc 1157221 tgaagcgaaa gaacagcttg agaaatcagg cattgagctc tcaatggagg ccatccagcc 1157281 gtttatgaat ctatttacaa cggtaatggc ggaagcttat gagcttggca agtctgacgc 1157341 taaatctgaa acagaataag aagaagccac ttttttgaaa gtggcttttc acatgatttt 1157401 ctttttaata gcggagagca tgggcgcaag ctcctttaaa gcgggcttga tttgatcaag 1157461 agagttcata attgaaccga tttggtccat aatatgcatg taattaatcg tctcttcgtc 1157521 gtttgtctga gaaacctgag aaacttcctc ttgctgttcc tcctccttct cttctgttgg 1157581 ttttgctgca tcgccgaaca tcattcttga aaacacatcc aactgcatac gcctcctttc 1157641 catataccat actctatgag taagatgaac tgatagttta gacgaatata ttgccatgtg 1157701 aaaaaaaata ggatagaatt agtacctgat actaataatt gatcacaacc tgattgatct 1157761 tctaaattta agatataaag gagtcttccc taatgaaagc tggaatactt ggtgttggac 1157821 gttacattcc tgagaaggtt ttaacaaatc atgatcttga aaaaatggtt gaaacttctg 1157881 acgagtggat tcgtacaaga acaggaatag aagaaagaag aatcgcagca gatgatgtgt 1157941 tttcatcaca tatggctgtt gcagcagcga aaaatgcgct ggaacaagct gaagtggctg 1158001 ctgaggatct ggatatgatc ttggttgcaa ctgttacacc tgatcagtca ttccctacgg 1158061 tctcttgtat gattcaagaa caactcggcg cgaagaaagc gtgtgctatg gatatcagcg 1158121 cggcttgtgc gggcttcatg tacggggttg taaccggtaa acaatttatt gaatccggaa 1158181 cctacaagca tgttctagtt gttggtgtag agaagctctc aagcattacc gactgggaag 1158241 accgcaatac agccgttctg tttggagacg gagcaggcgc tgcggtagtc gggccagtca 1158301 gtgatgacag aggaatcctt tcatttgaac taggagccga cggcacaggc ggtcagcact 1158361 tgtatctgaa tgaaaaacga catacaatca tgaatggacg agaagttttc aaatttgcag 1158421 tccgccaaat gggagaatca tgcgtaaatg tcattgaaaa agccggactt tcaaaagagg 1158481 atgtcgactt tttgattccg catcaggcga acatccgtat catggaagct gctcgcgagc 1158541 gtttagagct tcctgtcgaa aagatgtcta aaactgttca taaatatgga aatacttctg 1158601 ccgcatccat tccgatctct cttgtagaag aattggaagc cggtaaaatc aaagacggcg 1158661 atgtggtcgt tatggtaggg ttcggcggag gactaacatg gggcgccatt gcaatccgct 1158721 ggggccgata aaaaaaggtg aggtgcacac aagatgacta aaaaaagagt agttgttaca 1158781 ggacttggag cattatctcc acttggcaac gacgtcgata caagttggaa taacgcaatc 1158841 aacggtgtgt ccggaatcgg tccgatcact cgtgttgacg ctgaagaata tccggcaaaa 1158901 gttgccgctg aattaaaaga ttttaatgtt gaagattata tggataaaaa agaagccaga 1158961 aaaatggacc gctttacaca atatgcggtt gtggctgcga aaatggcggt tgaagatgca 1159021 gatcttaaca ttaccgatga gatcgcgccg agagtcggtg tttgggtagg ctccggtatc 1159081 ggaggacttg aaacactaga gtctcaattt gaaatcttct taacaaaagg cccaagacgg 1159141 gtaagcccgt ttttcgtgcc aatgatgatt cctgacatgg cgacaggcca gatttctatt 1159201 gcattaggag caaaaggggt gaactcttgt acggttacag catgtgctac aggaacgaac 1159261 tccatcggtg acgcgtttaa ggttattcag cgcggtgatg cagacgtgat ggtcacaggc 1159321 ggaacagaag cgccgctgac aagaatgtca ttcgccggct ttagtgccaa caaagcgctg 1159381 tctactaatc cagatccgaa aacagcgagc cgcccgtttg ataaaaaccg tgatggcttt 1159441 gtcatggggg aaggtgcagg gattatcgtt cttgaagaac ttgagcatgc cctggcccgc 1159501 ggcgctaaaa tttacggaga aattgtcggc tacggctcaa ccggagacgc ttatcatatc 1159561 acagcgccgg cccaagacgg tgaaggcgga gcgagagcga tgcaagaagc cattaaagat 1159621 gcaggcattg cacctgaaga aattgattac atcaatgctc acgggacaag cacgtattac 1159681 aacgacaaat acgaaacaat ggcgattaag accgtttttg gcgagcatgc gcataaactt 1159741 gcggtaagct ctacaaaatc gatgacaggc cacctcttag gagcagccgg cggtattgaa 1159801 gccattttct ctatcctggc cattaaagaa ggcgtgattc cgccgacaat caatattcaa 1159861 acacctgacg aagaatgtga tttggattat gtgcctgatg aagcccgcag acaggaactt 1159921 aattatgttc tcagcaactc attaggattc ggcggacaca acgcaacatt aatctttaaa 1159981 aaatatcaat cataatcaag ccaaaccggc tgcccttaaa gggtagccgg ttttttttgt 1160041 gtgcatagga ttaaaagagg aggcgatcac atgagtgtag aacaaacata tagctggctc 1160101 aggaaggccg gttcaataga tgatttggcg cattacatta tcccgctttt ttcaggtgcg 1160161 gagaaaaaga actggaaggg cattctgggg catcttcagc atcatgggat gtttaaaaac 1160221 ataaaagagg gtattcagac ggtttccaag ctgaaggaaa aaggttttta cggacatatc 1160281 caaaaggaag aacagtacct caaaaacaaa tggcaaggtc ctgatgtacc aattgttacg 1160341 ctgccggttg atgaacgaaa caggagaatc cgtttagaat tcggatcaaa atcaggactc 1160401 gcctttcaag acaaaatgtt cctttttctt tcgtcagatt tagattttgg gtcggtatct 1160461 gcccttatga cgcatgagta tcatcacgtt tgccggttag gtcatctgac aaaagaggaa 1160521 aaggatgtca cattacttga tacaatcatc atggaagggc tggcggaata tgctgtttat 1160581 gagaggttcg gccgaagtca aacggctgaa tggacgactt ggtatacacc ggaacagctt 1160641 caggctttat atgaaaaaaa gattgcgccc catcgggata tcaaacggga taatcgatta 1160701 tttccccagc tgttattcgg caaaggatat cagccaaaaa tgcttggata cgcagttgga 1160761 ttcaatattg taaaaaaata tttaaccgcc agcaaggcaa gcaccgcaga cgggctgtcc 1160821 attcctgctg agaccttttt ggatgcaatg ctttaaaagg ataaaataat ggaatttcat 1160881 taataatatt acatttatcc taaaaaattc ttgattttgc aaaatgattg taataatata 1160941 caactataaa atttttcgat aattcaatat tatttattat ttctgaataa agggattgct 1161001 ttctcttgaa aacgtttgac aacaagaggg gggaaagggg agctagcatg agcacacttt 1161061 tagaagtgaa taatttaaag acttattttt tcaggaaaaa ggagccgatc cctgcggttg 1161121 acggagtcga ttttcacatc agcaaaggcg aaaccgtcgc gcttgtaggt gaatcgggct 1161181 ccggaaaaag cattacttct ttatcaatta tgggcctcgt ccaaagctca ggcggaaaaa 1161241 tcatggacgg ctctattaaa ctcgaagaca aagacctcac ctcattcact gaaaacgatt 1161301 attgcaaaat ccgcggtaac gaagtatcca tgatctttca ggaaccaatg acctccctta 1161361 atccggtgtt aacaatcgga gaacaaatta ccgaagtgct gatttaccat aaaaacatga 1161421 agaaaaaaga agcccgtcaa cgagctgttg aactcttgca gatggtcggt ttctcccggg 1161481 cggagcaaat tatgaaggag tacccgcatc ggctgtccgg cggtatgaga cagagggtga 1161541 tgattgccat cgcactgagc tgtaatccta aactgctcat tgctgatgaa ccaacgacag 1161601 cgctggacgt gacaatacaa gcccaggtgc tggagctcat gaaagatctc tgtcagaagt 1161661 tcaatacatc gattcttctc atcacacacg acttaggtgt cgtgtctgaa gctgccgata 1161721 gagtgattgt catgtactgc ggacaagtcg tagaaaacgc cactgttgat gacttatttt 1161781 tagaaccgct tcatccgtat acagaaggcc tgcttacgtc aattcctgtt atagatggag 1161841 agattgataa attaaatgcg attaaaggca gtgtgcctac accggataat ctgccgccgg 1161901 ggtgccgttt tgccccaagg tgcccgaaag ctatggataa gtgctggaca aatcagcctt 1161961 cgcttttgac acacaaaagc ggaagaacgg tgagatgctt tttatatgag gaagagggtg 1162021 ccgaacaatc atgacagcag ctaatcaaga aacaatctta gagcttcgtg acgtaaaaaa 1162081 atactttccg atccggtcag gcctttttca aagaaaagtc ggtgatgtaa aagcggtgga 1162141 tggtgtttca ttttcgttaa aaaaaggaga aacactcgga atcgttggag agtcgggctg 1162201 cggaaaatcg actgccggca gaacgatgat cagactgtac aaaccgacag agggccaaat 1162261 tctttttaaa gggcaggata tttccaatct gtcagaggag aagctgcgga agagtgtccg 1162321 caaaaatatt caaatggttt tccaagatcc atttgcttcg ttaaacccga gaaagaccct 1162381 gcgttccatc ataaaggagc cgtttaatac gcacaacatg tataccatgc gtgaacgaaa 1162441 cgaaaaagtt gaagagctgc ttgcaagagt agggcttcac ccgtcgtttg ccggccgtta 1162501 tccccatgag ttttcaggcg gccagcgtca gcggatcggc attgccagag cactcacttt 1162561 gaatccagag ctgatcattg cagatgagcc ggtttccgca cttgatgtat ccattcaggc 1162621 ccaagtgatt aacttgatgg aggaattaca ggaagaattt aatcttacgt atctatttat 1162681 ctctcatgat ctgagtgtcg tccgccatat cagcgacaga gtcggagtaa tgtatcttgg 1162741 caaaatgatg gaactgaccg gcaagcatga gctttatgac aacccgcttc acccatatac 1162801 ccaagcgctt ttatcctccg ttccggttac aagaaaaaga ggttctgtca aacgtgaacg 1162861 cattgtcctg aagggagaac tgcctagtcc ggccaacccg ccaaaaggct gcgtattcca 1162921 cacaagatgt cctgttgcaa aaccgatatg caaggaacaa ataccagaat ttaaagaagc 1162981 tgctcccagc cactttgtgg cttgtcacct ttatagctaa tgttgcccgc acagctttga 1163041 gagggggtat gcacactaca taaacaacag cctagaagaa cgaacatttc aagaggggga 1163101 atatctaatg aaaagacgga aaaccgcact gatgatgcta agtgtattga tggttctggc 1163161 catcttttta tcagcctgct cgggatcaaa atcaagcaac agcagcgcga aaaaatcagc 1163221 aggcaaaccg cagcaaggcg gggatttggt tgttggttca atcggagaac ccacactttt 1163281 taactctctg tattctaccg atgacgcaag tacggatatt gaaaatatgc tgtacagctt 1163341 tttaacgaaa acggatgaaa aactaaatgt gaaattgtca ctcgctgaaa gcattaaaga 1163401 attagacggc ggccttgcat atgatgtgaa aattaaaaaa ggcgttaagt ttcatgacgg 1163461 aaaagaactg actgcagacg acgtcgtatt tacgtacagt gtccctttaa gcaaagatta 1163521 caagggagaa cgcggttcaa catatgaaat gctgaaatcc gtagaaaaaa aggcgattac 1163581 gaagtcttgt ttaagctgaa atataaagac ggtaatttct acaacaatgc gttagacagc 1163641 acagctattc tgccgaaaca tattctcggt aatgttccga ttgctgattt agaagaaaat 1163701 gagtttaaca gaaagaaacc aatcggttca ggaccattta agtttaagga atggaagcag 1163761 ggccaatata ttaagctcga agcgaatgat gattactttg aaggaagacc gtatttagat 1163821 actgtgacgt ataaagtcat tcctgacgca aatgctgccg ttgctcagct gcaggcaggc 1163881 gatattaatt tctttaatgt gcccgccact gactacaaaa cggctgaaaa attcaacaac 1163941 ctaaaaatcg ttactgattt ggcattaagt tatgtgtaca tcgggtggaa tgaaaaaaat 1164001 gaattattca aggataaaaa ggttcgtcaa gcgctaacaa ccgctcttga ccgcgagtca 1164061 atcgtcagcc aagtattaga tggagacggc gaggtagctt acattccgga aagcccttta 1164121 tcttggaact atcctaaaga tatagatgtt ccgaaatttg agtacaacga gaaaaaagcg 1164181 aaacagatgc ttgcagaagc cggctggaaa gatacgaacg gtgacggcat tctggataaa 1164241 gacggaaaga aattctcgtt tacccttaaa acgaaccaag gaaacaaagt ccgtgaagac 1164301 atcgctgtcg tcgttcagga acagctgaaa aaaatcggca ttgaagtgaa aacccagatc 1164361 gttgaatgga gcgctctcgt tgaacaaatg aatcctccga attgggattt tgatgcaatg 1164421 gtcatgggat ggagtttatc cacattcccg gatcaatatg atattttcca ttcaagccag 1164481 attaaaaagg gtttgaacta cgtttggtat aaaaatgccg aagcggataa actcatgaaa 1164541 gatgcaaaat caatcagtga cagaaagcag tattcaaaag aatatgagca aatctatcaa 1164601 aaaattgcgg aagatcagcc gtatacgttc ttgtattatc ctaacaacca tatggcaatg 1164661 ccggaaaatc ttgaaggata caaatatcat ccgaaacgtg atttgtataa tattgaaaaa 1164721 tggtggcttg caaaataaat ttcccttaaa ggggagggag agcgttttct ccctcttctg 1164781 tttttaataa ggaaagtaaa gggggacaag tatatggctg catatattat cagaagaacc 1164841 ttaatgtcta tcccgatttt attgggaatt acgattttat catttgttat catgaaagcc 1164901 gcgcccggag atccgatgac attaatgatg gacccgaaaa tcagccaggc tgacagagag 1164961 cagtttattg aaaaatacgg tctgaatgat cctcagtacg ttcaatattt aaagtggcta 1165021 ggcaacatgg tgcagggtga tttcggaacg tctattgtca gaaaaggaac gcctgtttca 1165081 gaattgatta tggcaagact acccaatacg ctcctgctga tgctggtttc aacgattttg 1165141 gctcttatga tttctattcc gttcggtgtc ctgtcggcaa agcggccgta ttcaaaaatc 1165201 gactatggca ttacatttac ctcgtttata ggcctggcta ttccaaactt ttggtttgga 1165261 ttaattttga ttatggtgtt atcggtaaat ctcggctggt ttccaactgg gggtgtcgag 1165321 acactgaata ccgaattcaa tatatttgac cggattcatc atttaattct gcctgcattc 1165381 gttctagcta cagctgacat ggccggactg acgagataca cgagatccaa tatgcttgat 1165441 gtattaaatc aagattatat tcgcacagcg agagcaaaag gatttaaaga gaacagagtg 1165501 ctatttaaac atggattgag gaatgcatta ttacccgtca ttacaatttt cggtttgatg 1165561 attccttcat ttatcggcgg atctgtcgtt gtcgaacaaa ttttcacttg gccgggatta 1165621 ggaaagctgt ttgtcgattc agcattccag cgcgattatc cggttatcat ggcaatgact 1165681 gtgatctcgg cggttcttgt cgttgtcgga aacctcattg cagacatcct ttacgcgatt 1165741 gttgatccgc ggatcgaata ttaaaaggag ggaaacagag atgtcagagc tgcaaacaac 1165801 tccctcgccg gagatcaggc tgaaagaaaa tatttcgaaa aagccagaaa caatgacaaa 1165861 gattttctgg gaaaaattct cgaaaaacaa actggccatt ttaggtgccg ttattctttt 1165921 tatcattatt atgtctgctg ttttcgcccc tttaattgca ccttatcccc aagagcagca 1165981 aagcctgctt gataaatata aggcgccggg ccttgaacat ctgatgggaa cggataaatt 1166041 tggacgtgat attttcagcc ggatcctata tggagcgcgt gtctctttat tggttggatt 1166101 tgcgtccgta gtcggttcga ttttgatcgg aacggtttta ggagcattag ccggatattt 1166161 cagaggaata gtggatgctg tcattatgcg tgtagttgac attgtgttat ccattcctga 1166221 tattttcttg ttgatcacgc tggtcaccat cttcaagccg ggtgtggaca aattgatttt 1166281 aattttctgt ctcacaggat ggaccacaac agcacgatta gtaaggggag aattcttgtc 1166341 gctccgttca agggaatatg ttcttgctgc taaaacaatt ggaacaaaaa cgcacaaaat 1166401 tattttttct catatcctgc ccaatgcgtt agggccgatt atcgtgtcag ctacgctgaa 1166461 agttgggtct gttattctag ctgaatcggc gctaagctac ttgggctttg gaatccagcc 1166521 gccaatcgct agctggggga acatgcttca agacgcacag aatttcacag taatgattca 1166581 agcatggtgg tacccgttat ttcccgggct atttatttta atgaccgttt tatgcttcaa 1166641 ctttgtcggt gatggcctgc gggatgcgct tgacccgaaa aatattaaat aaaaatgaat 1166701 atcatatctg ttataaaata tcaccaaatc agaaaaaagc aggtctcctt tagtcagaaa 1166761 atatacaaag agatctgctt tttatgattc ttacataaac ccagtgattc cagatttcct 1166821 caatctcttt ggaataattt ctctatccct tgcctatact gtggacaaca gtttttataa 1166881 aagtgagggg ttagagatgt tatttcttca tgatgtgtgg gtcaattggt ttgaagggga 1166941 agaaaatggc tacaatgtat gccactttca cgaatggcgc aaggaagata cggttgagct 1167001 tttggatcag gtgccgctgt taagggtgcc gtcagtactg tttcattaca tagaaaacga 1167061 tttgtcagag cttccgaaag gtttgcttga agacgtacat cagaaatcgt acattcgaaa 1167121 aaatcatgag cggacaaagc ttgagtattg ttttgtcgta acagacggaa tcggcatttt 1167181 agctgttgac acgatcggct acacgatccc tgtcagaaaa agccgtctaa tcccaagaca 1167241 ggagcagctc gtttatgaaa tggtaaaaga tgtagagcct gaaacatatg aatttgagcc 1167301 aaagaagctg gaatcctcca aggaatatca catcttatca ttagcaccag aacatgtcag 1167361 aggactgaca agaaaagaac ggcaaattaa gcagctgatg tttatggcgc ttgaccaatt 1167421 aaaagggctg aaaaaccgag cggaaattgg ctactggtac acagagtgga atccgcatat 1167481 gtatgaacaa atcaaaagga tgagctttga agagatttgg gacatgctgt ataacgaaac 1167541 aattgaaggc tggtcggaca aacacctagc tttttgcgaa aacctaataa aaggacagcc 1167601 ttttttcgaa aagctttggg aaatggaaaa cgaatcaaag gtcaactgaa aaaaaccgct 1167661 ctttgcaaag agcggttttt tgattagcgt ctttttcttc caagacccat ggcattctcc 1167721 atttttttca gcattttgtt tgctgtccga ttcgctcgtt ccgcgccttc atcaagaatc 1167781 cggtctaatt cttcagattc tatcagctcg taatagcggt cctggatcgg ttttaatgcg 1167841 ttcactacga cttctgccaa atcaccttta aactcgccgt agccttttcc ttcgtacttt 1167901 gcttcaagct cttcaattgt cgtattgccg aggattgaat aaattgtaag aaggttggaa 1167961 acgcccggtt tgttttcctt atcaaatttg acaatgcctt cagaatccgt tactgcgctt 1168021 ttgattttct tttcaagctg cttcggctca tccagcaatg taatataagc tttctgattc 1168081 ggatcagatt tgctcatttt cttcagcgga tcattcagag acatgatacg tgcaccgact 1168141 tttggaattt tcacttccgg aatcgtaaag atgtcgttgt attttttgtt gaagcgttct 1168201 gcaagattcc gcgtcagctc aaggtgctgc ttttgatcct cgccgacagg tacaagatcc 1168261 gttccgtaca gcagaatatc agcggccatc agcggcggat atgttaacag gccggagacg 1168321 acagcttcat tgcctttgga tttgtcctta aattgagtca tccgctcaag ctcgccgata 1168381 taggcgacac actgcatcat ccatccggcc tgcgcatgtg cggggacctc tgactgaata 1168441 aacaatgttg ctttttctgg atcaagtccg acagctaagt aaagcgccgc gagattgcgg 1168501 atattctttc taagctcaag ccggtcttga ggaacagtta tcgcatgctg atcgacgatg 1168561 caaaaatagc tgttataatc atgctgcagt tcgacaaact gcttcattgc accgatatag 1168621 ttgccgagcg tcactgagcc gcttggctga atgcctgaaa aaatcgtttg tttcatgaaa 1168681 acatcaacct catttcttaa aacataataa aaaaggctca ttcttcccct gtaaaaaagg 1168741 gacgaatgaa ccgtggtacc accctgatta ttccattaaa atggaatcac tctgacgttt 1168801 gtaacggaga ctgctccggc tgagcctact tttttccagt tcggtcagct gctccaaagt 1168861 ccattccaca ttgcccgtta tctgctccca gcaccgcaga ctctcttcaa acaggtgaaa 1168921 cgtgtactac tctttttcat agcaagcttt tcttttgatt gcttcattat aaatcaatta 1168981 taaccaattg tcatcatgaa aaaacattct tttttccagt aaaattgtaa taatataaat 1169041 aacacgagtg ctgtaaaatc cttaaatgat aactgctatc agcgtaaaaa caggcagata 1169101 ttatatgtaa aaagcaatat gggcagaaaa cacatgaaaa agtttttaat caatttatgc 1169161 tttaaatggt agaaggatat tatgttcatg gaagaaaaac taacgaagtt taaatatttt 1169221 aaattgataa aataatattg caataaatta tttgtttcat tataatgaac ttgttcactc 1169281 tattgttaca gcttttttac aaaaataatc agaaaagacg gaacagaata aaagttgtgg 1169341 aaactcaggt tcatttgtct gatatttctg aggatttagc cgtaaggagc tgaaaattat 1169401 tattaggggg tttgcgaata tgaaaaaacg ttggtcgatt gtcacgttga tgctcatttt 1169461 cactctcgtg ctgagcgcgt gcggctttgg cggcagcgga tcaaacggtg aagggaaaaa 1169521 ggacagtaaa ggaaagacga cacttaacat taatattaaa actgagccgt tctccttaca 1169581 tccgggattg gcaaatgatt cagtatcagg cggtgttatc cgtcagactt ttgaaggatt 1169641 gacacgtatc aatgcagatg gtgagcctga agaaggcatg gcttctaaaa ttgaaacgag 1169701 caaggacgga aagacatata catttaccat tcgtgatggt gtgaaatggt ctaatggaga 1169761 ccctgtaact gcacaagatt ttgaatatgc ttggaaatgg gcgcttgacc ctaataatga 1169821 atcacaatac gcttaccagc tctactacat aaaaggtgct gaagcggcga ataccggaaa 1169881 aggcagccta gacgatgtgg cagtaaaagc tgtgaatgac aaaacgctga aggttgaatt 1169941 aaataacccg actccatatt tcactgaatt aactgcgttc tatacgtata tgccgatcaa 1170001 taagaaaatt gcagagaaaa ataaaaagtg gaatacaaat gccggagatg attatgtatc 1170061 aaacgggccg ttcaaaatga cggcatggaa acacagcggc tctattactc tcgaaaaaaa 1170121 tgaccagtat tgggataaag acaaagtcaa actgaagaaa atcgatatgg ttatgatcaa 1170181 caataacaat acggaactaa aaaaattcca agctggcgaa cttgattggg ccggtatgcc 1170241 gctcggacag cttccgacag aatccctgcc gaccctgaaa aaagacggtt ctttacatgt 1170301 tgagccgatt gcaggagtgt attggtacaa attcaacact gaagctaagc cattagacaa 1170361 cgtcaatatc cgtaaagctt taacatattc gcttgaccgt cagtcgattg ttaaaaacgt 1170421 tacgcaagga gagcaaatcc cggcaatggc tgcagtgccg cctacaatga agggatttga 1170481 ggataacaaa gaaggatact tcaaagacaa tgatgtcaaa acagcaaaag aataccttga 1170541 aaaaggccta aaagaaatgg gcttaagcaa ggcatctgat ttgccaaaaa tcaaattgtc 1170601 ttacaacact gatgacgcac acgcgaaaat cgctcaagca gtacaagaaa tgtggaagaa 1170661 aaatttaggc gttgatgttg agcttgataa ctcagagtgg aatgtctata ttgataagct 1170721 ccacagccaa gattatcaaa tcggccgtat gggctggctc ggcgacttca atgatcctat 1170781 caacttcctt gaattgttcc gcgacaaaaa cggaggaaat aacgatacag gctgggaaaa 1170841 tccagaattc aaaaagcttc tgaatcagtc acaaactgaa acagataaaa caaaacgtgc 1170901 agagctgctg aaaaaagcag aaggtatttt cattgatgaa atgccggttg ccccaatcta 1170961 tttctatact gatacttggg tacaggatga aaacctaaaa ggtgttatca tgccaggtac 1171021 tggtgaggtt tatttcagaa acgcatattt taaataaggc tacgtctgaa aataaaagac 1171081 ctcaaggtat atggggagaa aagccccata tacctttctt actgatggag tataaaaatg 1171141 taaaaaccat ggaggtgttc ccccttgcta aaatatatcg gaagacgctt agtctatatg 1171201 attatcacac tatttgtgat tgtaactgtg acattcttct taatgcaagc agcaccgggc 1171261 gggccatttt caggtgagaa aaagcttccg cctgaaattg aagcaaattt aaatgcgcat 1171321 tatggcttgg acaagccgct gtttgtacaa tatgtcagtt atttgaaatc agttgcaatg 1171381 tgggatttcg gaccgtcatt taaatataaa ggtcagagtg ttaacgacct gatcagttca 1171441 ggtttccccg tttcatttac tcttggagca gaagctattc tcctcgcttt agcgttaggt 1171501 gtattgtttg gggtcattgc agccctttac cataataagt ggcaggatta taccgtcgcg 1171561 attttaacga tatttggtat ttcggttccg agctttatca tggcggctgt tctgcaatat 1171621 gtgttctcca tgaagcttgg gctgtttccg gtcgcggggt gggattcctg ggcatacacc 1171681 tttttgcctt ccatcgcact tgcttccatg ccgatggcgt ttattgccag actttcccgt 1171741 tcaagcatga tcgaagtgtt aaacagtgat tatatccgca cagcgaaagc gaaagggctt 1171801 tcccgcccag cggttacagt gcggcacgcc attcgaaacg cacttttgcc ggttgttaca 1171861 tatatgggcc cgatggccgc acaggtctta acggggagct tcattattga aaccattttt 1171921 gggattccgg ggcttggtgc acacttcgtc aacagtatta caaaccgtga ttatacggtc 1171981 attatgggtg taacggtgtt cttcagtgtc atcttgctat tgtgtgtatt aatcgtagat 1172041 gtgttatacg gcattattga tccaagaatc aagctttcca aagcaaagaa aggagcctag 1172101 gccatgcaga acattccaaa aaacatgttt gaaccagccg cagcgaatgc cggcgatgca 1172161 gaaaaaataa gtaaaaagag cctttccctc tggaaagatg cgatgcttcg cttccgcagc 1172221 aataagcttg caatggtcgg gcttatcatt atcgtactta ttatccttat ggcaattttt 1172281 gcgccgatgt tctcaaggta tgattattca actactaatc tcttaaatgc ggataagccg 1172341 ccttcaaaag atcactggtt cggaacagat gatcttggac gggacatttt cgtccgtaca 1172401 tgggtagggg cgcgaatctc aatctttatc ggtgttgcag ctgctgttct cgatttgctg 1172461 atcggcgtca tttgggggag catttcaggc ttccgcggag gaagaacaga tgaaatcatg 1172521 atgcgtatcg ctgatatcct ttgggcagtt ccttcattat taatggttat cttactgatg 1172581 gttgttcttc cgaaaggtct atttacgatt attattgcca tgacgattac aggctggatt 1172641 aatatggcca gaatcgtgcg cggacaagtg ctgcagctga agaatcagga gtatgtgctt 1172701 gcttcacaga cactgggtgc aaaaacatcc cgtcttctat ttaaacatat cgtgccaaac 1172761 gcaatgggtt ctattttggt cacgatgaca ctgacagttc ctactgcgat ttttacagaa 1172821 gcctttttaa gctatttggg acttggtgtt ccggctccgc tggcaagctg gggaacgatg 1172881 gcttctgacg gattgcctgc attgacctat tatccgtggc gtttattctt ccctgccgga 1172941 tttatctgca ttacaatgtt tggttttaac gttgtcggcg acggattaag agacgcattg 1173001 gatcctaagt tacgtaaata agggagtgat acgggtgaca cgcctattag aagtaaaaga 1173061 tttagcaatt tcatttaaaa catatggcgg agaggtccag gcgatccgcg gagtgaattt 1173121 ccatctggat aaaggggaga cgctggccat tgttggagaa tcaggttccg gaaaaagtgt 1173181 aacctctcaa gcgattatga agctgattcc aatgcctccg ggttatttca aacgcggtga 1173241 gatcctgttt gaaggaaagg atctggtgcc gctgtccgaa aaagaaatgc aaaatgtccg 1173301 gggaaaagag atcggcatga tattccaaga tccgatgacc tctttaaatc caacgatgaa 1173361 ggtcggtaaa caaattacgg aagtgctttt taaacacgaa aagatctcga aggaagcggc 1173421 taaaaaacgc gcggttgaac tgctggaatt agtcggtatc ccaatgccgg aaaagcgggt 1173481 gaaccaattt ccgcatgaat tttcaggcgg gatgagacag agggttgtca ttgccatggc 1173541 gcttgcagcg aatccgaaac ttctgatcgc cgatgagccg acaactgctc ttgatgtaac 1173601 gattcaagcg caaattttgg aattaatgaa ggatttgcaa aagaaaattg acacgtccat 1173661 catctttatc acacacgatc ttggtgttgt ggctaacgtt gctgaccggg tcgctgtcat 1173721 gtacgcggga cagattgtag aaactggtac ggtagacgaa atcttctacg acccgagaca 1173781 tccgtacact tgggggcttc ttgcatccat gccgacactg gaaagttcag gagaggaaga 1173841 gctgactgca attccgggca cgccgcctga tttgacaaac ccgccaaaag gagatgcttt 1173901 tgccctgcgg agctcttacg cgatgaaaat cgattttgaa caggagccgc caatgtttaa 1173961 ggtatccgat actcattatg taaaatcgtg gctgcttcat cctgacgcgc caaaggtaga 1174021 gccgcctgaa gcggtaaaag cgaaaatgcg taaactggca aacacgtttg aaaaacctgt 1174081 cttagtgaga gaagttgaat gaattgactg aaaaactatt agaaatcaaa catttaaaac 1174141 agcactttgt cacgccgagg ggaacggtta aggctgtaga tgatttatca tttgatatct 1174201 ataaaggtga aacattaggg ctggttggtg aatctggctg cggtaaatcg acaacaggcc 1174261 gaagcattat caggctgtac gaagcaaccg atggtgaggt gctgttcaac ggcgaaaatg 1174321 tgcacgggag aaaatcgcgg aaaaagctgc tggaattcaa ccgcaaaatg cagatgattt 1174381 tccaagaccc ctatgcatcc ctgaatccga gaatgacagt tgctgatatt attgctgaag 1174441 gccttgatat tcataagctg gcaaaaacga aaaaagagcg gatgcagcga gttcatgaac 1174501 tattggaaac agtgggattg aacaaggaac acgcgaaccg ctatcctcat gaattttccg 1174561 gcggccagcg ccaaagaatc gggattgcca gagcgcttgc tgttgatccg gaattcatta 1174621 tcgcggatga gccgatttcc gctttggatg tatccattca agcgcaggtc gtgaatttaa 1174681 tgaaagaact gcaaaaagaa aaagggctca catacctgtt tattgcccac gatttatcga 1174741 tggtcaaata catcagtgac cgcattggcg tcatgtattt cgggaaactg gttgagcttg 1174801 cgccggcaga tgagctttat gaaaatccgc ttcacccata tacaaaatca ttgctttctg 1174861 cgattccgct tcctgatccg gactatgaga gaaatcgcgt tcgccagaaa tatgatccgt 1174921 ctgtccatca attaaaggat ggggaaacga tggaattccg tgaagtcaaa ccgggacatt 1174981 ttgtgatgtg cacggaagcc gaatttaaag ctttttcatg attcatcaat ccttcaagag 1175041 atttctcttg aaggattttt ttgcgtcttc atagaaagtg agaatgataa catttacaat 1175101 tagaggaaaa agcggaggcg aaatacgatt caatttctgc ataacaaaaa tgtttttgcg 1175161 ctattgctgt ctcaatcttt tcaatcttta gcaggagtcc tcgtcacaat cgttttaatg 1175221 gtccggatct atcaaatgac tgactccgtt tttttggcgg gccttatttt atcgttcatg 1175281 tcgtttgcga gtatagcagc aagcttttgc gtctctccgg tgcttcgcat tctcggtttt 1175341 aaaaaggtgc ttgcgggagc gaatctgctg agagcggtct ttattatact gatggcatac 1175401 agcgtcactc atcacggaca ggcattcttt tggattacgc tgctgtttgt gttttgtttt 1175461 tccttcgcgg gcgctttttt tcagccggca agatttgcgc tgctgccgat tattgttcca 1175521 aagaagcaat atgtaaaagc gaatggtgtg atctccctct cgaatcaatt gttcttaaca 1175581 gcaggctggg gccttggagg ccttctgacg tacgccgtcc cttttgaact cgttgtcggc 1175641 gctgccattt gcctgtttgt tctatcggga gcttccatca gtgtgctgca tgtaaatgaa 1175701 gaagaggctg caggaactgc tgaaacagca tctgtcagaa gtatatggaa ggatttaatg 1175761 atcatcccta ttgtaagaga cattactgta atggacatgt tagaagcttt ggcgggttcc 1175821 gtatggtcat ctgctattct cctcgcattt actgcggctg ttttgcatga aacagaggtg 1175881 tggtggggga tgtttaacgc ttcctatttt ataggcgcaa ttgtcggcag tgtgattgct 1175941 attcgttttt cttctttttt tgagcggaat atgggctatg ccattatgtt cagctcgctt 1176001 gtaatgtcgg cgctgaccct tttgttttca ttttctccag tcccattttt atgcgctctg 1176061 gcttgtgctg caatggggcc tttttatcag gtgcgtgata tttgccagga aaccatgctg 1176121 caggaagtta ttcccgagca gaaacgaatc ggaatcatgg ctgcaaaaaa tgcgattttg 1176181 actccttggt caggcgtcac ctactccatt atggggctag tggctgatgc tgctggtgcg 1176241 aaaatagctt ttatcgcggc tgctgcatta tatatcatga catttctgat tgcactggcg 1176301 cagccccgtc tggttcatta caggcgagaa aatcgagttc aatgagaaac acttcaaaat 1176361 gaacggagca gctggctccg ttttgctgaa aaaaaaatga aaccatggcg gaagttcgca 1176421 cgtctttata gatgtaaggc tgtttaaaca agaagaaatg gggtatatct aaaagtatga 1176481 agacaacgaa ctcataagga gcaaatcaat gaactggtat gaaaagctta gcgagtactt 1176541 tccaattgaa gaaatgaaat caaaagcgca tatggaagct cttctgaaag agcgaagcga 1176601 tatttatcat aaagatgaag gcaaacatca tattttaatg tttgcggaat tcgattcttt 1176661 tatcttcgtt gattatctgt atgtgtctaa ggatgcaaga gggcaggggc ttggcggcaa 1176721 attgatcgcg aagctgaaaa agaaaaataa gcccatattg ctcgaggtgg aacctgtgga 1176781 tgaagatgat actgatacag aaaaacgcct gaggttttat caaagagagc atttcaagca 1176841 tgctcagtca attgggtacc ggcgccggtc attggctacg aatgaagtaa acaagatgga 1176901 gattctgtac tggtcaccaa aaacagaatc agaagaagaa attcttgaag ccatgaaaca 1176961 gacatatgaa aacattcata cttataaaga tgagaaatgg tacggagaat cgtacgaaaa 1177021 aacggatgag gtcttggaaa tcatcgatga agaaaaacaa aaaaatattt tcgatcagtt 1177081 aagctaattg agaataagaa catatcatga acattaaaaa tttgctggat tgacacattt 1177141 ttttcttagg atactgttca cacttacttt tttatagtat aatacctgta aagattcctt 1177201 ttttagagta atttcaattt aagaataaaa tagatgttca tcctactaat tagaggagtg 1177261 aagatgaatg gttacactat acacatcacc aagctgtact tcatgcagaa aggcgagagc 1177321 gtggctcgag gagcacgaga ttccatttgt agaaagaaac attttctctg aacctttatc 1177381 aattgatgaa ataaaacaaa ttcttcgaat gactgaggac ggaacagatg aaatcatctc 1177441 aacccgttca aaagtattcc aaaaactgaa tgtgaacgtt gaatctatgc cgctgcaaga 1177501 tttgtaccgc ttgatcaacg agcatccagg tttgcttcgc cgtccgatca tcattgacga 1177561 aaaacgtttg caggtcggat ataacgaaga cgaaatcaga cgtttcctgc caagaaaagt 1177621 tcgctctttc caattaagag aagcacagcg tttggcaaac taatagatcg tatcatcaaa 1177681 agaaggctga gtcatcagcc ttcttttatt tttcaacctg ctggtaataa atgctcgcaa 1177741 ggatgacaaa cgcaaccgtc aaaatgggga ggagcgtttc gactgtgccg tgctgcgcca 1177801 taaaaagcga cagctttttg tctctgacaa tcatttctcc gccagtataa gcaagcagcc 1177861 cgcttcccgc gtaaatcaga agcggtattt tctctagtgc aatatggatg agtttgctgc 1177921 cccaaataat aaccggaacc gatacacaca atcctataac aacgagagaa aactcaccgt 1177981 gtgaagctcc cgcaactgcg atgacgttgt ccagcgacat aaagagatct gcaagcacaa 1178041 tcgttcgtat cgctctccac agggaggtgc tgcttttaat gtgtttcgtg tctttttttt 1178101 caatcagcag ctgatatcct aaatacagca ggaaaattcc gccggcgcac tgcaagaacg 1178161 gaatgttcaa aagatatact gctgcacttg ttaatccgat tctcatggca acggcaataa 1178221 atgttccgag aataatggct tgctgtcttt gcttgtccgg caaatgtctg ctggccatgg 1178281 caataacaac cgcgttatct ccgccgagga tcaggtcaat cccaacaatg acgagcagag 1178341 aaatcagata gtcatgctcc atgaagcggc acctcgcttt cagtccttcg cttgtactac 1178401 tactatatga gacaggtcat attttatgat atcagccgcc tgatctgccg ttttttaggc 1178461 aaaggtgcat ttttatttct tttgtgactg ttttatcata aaatagaaat acaaaggaat 1178521 tcacactggc cttggttaag gttaagatgt ggacggaatg ggtaaagtgt agtaaagtac 1178581 aattaatcgg gagcttagat gtcccttcaa catcttatat agaagggaag gttggcaaat 1178641 ggaaattgaa agaattaacg agcatacagt aaaattttat atgtcttacg gagatattga 1178701 agatcgcggt tttgacagag aagaaatttg gtataaccgt gagcgcagtg aagaactttt 1178761 ctgggaagtc atggatgaag ttcatgaaga agaggaattc gctgtggaag gcccactttg 1178821 gattcaagtt caggcactgg acaaaggatt agaaatcatc gtcacaaaag cccagctttc 1178881 caaagacgga caaaagctcg aactgccgat tcctgaggat aaaaagcaag aaccagcatc 1178941 tgaggatctt gacgccttgc tggatgattt ccagaaagaa gagcaagccg tcaatcagga 1179001 agagaaggag caaaagcttc aatttgtctt gcgatttggc gattttgagg atgttatttc 1179061 tctatctaaa ttgaacgtta acggaagcaa aacgacttta tattcgtttg agaaccgata 1179121 ttatttatat gtagattttt gcaatatgac tgatgaagag gttgaaaatc agctaagcat 1179181 cctgctggag tacgcaactg aatcctcaat cagcatacac cgtcttgaag agtacggcaa 1179241 gctgattatt tcagagcatg ctctagaaac gataaaaaaa cactttgcat catagcaaac 1179301 cgatttcctt ccggaaatcg gtttttttta tgcacgaaaa tgccatttta gagatgtgaa 1179361 aaatcaaaaa catatagaca agcagaaaat acagcgaaca ggagttgatc atcttttcca 1179421 gaaagtatac ttcatctgga aaggagagat gacaattgtt tagtgctgtg actgaagacg 1179481 gccaaatgtt tcaccttcta ggcgctcagc aaaaccagaa attaaagcgg agacggttct 1179541 tctgtccggt atgcggggga gagctagctg tgaagctcgg acttcaaaaa gcgccgcatt 1179601 ttgcccataa acagaacaag tcctgcgcca tagacatcga gccggaaagc gcctaccact 1179661 tagaaggaaa aagacagctg tatgtatggc tgaaaacgca acgggcttca ccaatattgg 1179721 agccgtatat aaggacaatc aaccaaagac cggacgtcat ggcaagaatc aaggagcata 1179781 tgcttgctgt tgaatatcaa tgcgccacta tcgctccaga tgtctttcaa aagcggacag 1179841 agggcttcaa acaagaagga atcatcccgc agtggattat gggatacagc cgcttaaaac 1179901 ggactgcttc gtccttttat cagctttcaa cttttcattg gcagtttatc aatgcaagtc 1179961 catacagaga actgatatgt tattgtcctg aaaggcgttc ttttctccgg ctcagccaca 1180021 tcattccatt ctacacaaac cattcttatt cctcagtcca aacgatccct atccatcggg 1180081 caggtgcagg cgatcttttt ttcactgaac cgaaaccctc aattcaatat tcaggctgga 1180141 cgaaagcgat tcaccgtttt cgccataaac cccatcggtt taactcaaag gaaacaaatc 1180201 gccttaggct gctgttttat gagaaacgac agacgccttt ttcttttctg ccgactgaag 1180261 tgtttgttcc tgttagaaaa ggggcagttt ttaagagtcc ggtttttgtg tggcaggggt 1180321 ttctttattt gtttatgacg gatcttggag gtaaacgtgc gccaattcgt ttttcagccg 1180381 ttttgcagca gtgcaaactg cacattcata ataagaacat tgcactcagg tccgaatgca 1180441 gcgaagagtg tctttcagaa gcggttaaac agtatattga ttttttgtgc aagaagggat 1180501 ttttaaggga gactcagaaa gaagtatatg tgctgaatca gcctgcagga ggcatacact 1180561 ccatgcagga tctcatagaa agagaccgca gctgttttat agaatgagtt tgtcttattt 1180621 ggctcaccct aagacaaagg tggtgggcag gctgtgaaag gcacaaaagg aaaggttttt 1180681 cgtgttttta ctgctttttt ggcattcgtt ctcttcatta ctgcatatga tttgacaaaa 1180741 ggcagtgaaa aaccggaaga tattcacaac acaagtttat tgagaaacag ctgttttttc 1180801 aattggcttg aatcaaagaa gacgaggggg atcaccatgg ctgaggaaaa aaaagcaaac 1180861 caactgcctg acagaagtga ggtaaaggca gaagacacat ggagacttga ggatattttt 1180921 cctagtgatg aggcctggaa taaagaattt caagctgtaa aagaattaat tccgaattta 1180981 tctaagtata aaggaaagct ggcagattca gctgatcatt tatacgaggc tcttacgtat 1181041 caagataaag tgatggagcg gctaggtagg ctgtacacat atgcgcatat gcgctctgac 1181101 caggatactg ggaactcctt ttaccagggg ctgaatgaca aggcgggaaa cctgtataca 1181161 caggccgcaa gcgcgacagc ttatttggtt ccggagattt tatccataga agaagacaaa 1181221 ctgcagcagt tcattcttga aaaagaagaa ttgaagctgt actctcatgc gattgaggag 1181281 attacaaagg aacgtccgca tgtgctgagc gagaaggaag aggcgctgct tgctgaagcc 1181341 tccgaggtac tggggtcatc ttcaaataca ttcagcgtgt taaataacgc agatataacg 1181401 tttccatcca ttaaagacga agatgggaat gaaaaacaga tcactcacgg caactttatt 1181461 aatttcttgg aaagtgaaaa ccgtgaagtc cgcaaaaatg cgtttgacgc agtgtataaa 1181521 acgtacggac aatataaaaa cacaatggcc acgacgctaa gcggcactgt gaaaaaggac 1181581 aacttctacg cgagagtgaa aaagtacaag tccgcgcgtg aggctgcgct ttctaacaac 1181641 agtattcctg aggaagtata cgataacctt gttaagacga ttaataagca tttgccgctc 1181701 ctgcaccgct atattgcgct aagaaagaaa gtgcttgagc ttgatgaagt gcatatctat 1181761 gacctgtata caccgcttgt gaaagatgct gggatgaagg tgacatacga ggaagccaaa 1181821 gattacatgc tgaaaggcct cgcaccttta ggggaagaat atgcctctat cctaaaagaa 1181881 ggactggaaa accgctgggt ggacgtttac gaaaataaag gcaaacgcaa tggggcttat 1181941 tcatcaggag cttacggcac gaatccgtat attttgatga actggcataa taacgtcaat 1182001 aatctcttta cgctcgtgca cgagtttgga cattccgtac acagctacta tacgagaaag 1182061 caccagcctt atccatacgg caattacagc atctttgtcg cggaagttgc ctctacgaca 1182121 aatgaagcgc tccttggcga atatttgctg aacaatttag aggatgaaaa acagcgctta 1182181 tatattctca accatatgct tgagggcttc aggggaacgg tcttcagaca aacgatgttc 1182241 gctgaatttg aacatctgat tcatacaaag gcgcaagaag gcgagccgct tacacctgag 1182301 cttctgacaa atgtctatta cgacctgaat aaaaagtatt ttggagacgg catggtgatt 1182361 gataaggaaa tcggccttga atggtcgcgt attccgcact tctattacaa ttactatgtg 1182421 tatcagtatg cgacaggtta cagcgctgcc caagcattaa gcagccagat tttgaaggaa 1182481 ggaaagccgg cggttgaccg ttatattgac ttcctgaaag cgggaagctc acaatacccg 1182541 attgatgtcc tgaaaaaagc gggtgttgat atgacgtctc cagagccaat cgaagccgcg 1182601 tgcaaaatgt ttgaagaaaa acttgatgaa atggaagagc tgctgatgaa agtcaagcag 1182661 tcttaaaaaa gtaagcctgt gcggaaatga cgcacaggct tttttaaaac cctttaaagg 1182721 ttttccggtg attcaagcgg tagagggtaa acaaaataga cagaaacagc agaggagagg 1182781 taatataaag cggcagcata tgcatcatgc ctaagatatt caagcagaaa aaaacagcaa 1182841 tgcacacaat tgagatcaaa gtagacatca tggcggtcct cctcgtcctt tttccttata 1182901 aggatatgag tgaatgcact tcgttatgtt ttgtgacaaa aatatgaaca ttaagcatag 1182961 aggttgtcaa aagtcgacat cttttgttat cataaggatg tgaaattgat cacaaacaaa 1183021 cattacccct ttgtttgacc gtgaaaaatt tctcccatcc cctttgttgt cgttaagaca 1183081 tatgaaaccg cgcttatccc ggcgcggttt ctttagtgct aaaaatggaa cgtacgtttg 1183141 gttatggcat aaaaaaacag cctcaagcat atgcacgcct gcggctattt ttcacatgat 1183201 tgatattcat cagaataagt gctgagagac ttccaaaaca ttccgtgttt ggcttccact 1183261 ttggcaacct ttttagcaaa cgccagtttt ttcatttctt tttctacctc ttcaaggctc 1183321 aggtcatata caagagcaat ttccttcgag gcaacgaagc ggaaatattc aataaaacat 1183381 tctaaaggcg gtgtttccga cggcttcggc tcgtcgccaa gcatctcaaa taaaatttct 1183441 tcatatacat catatgagta gctgccagga actttaagcc cttcatcctc atgctgcgta 1183501 ttaaaaaacg tcagtgtcgg attaacagaa acatccatct cggcagcaat tttcatgtca 1183561 cattgaagcg ccttgaccgc gctttgagaa tgcagatctt ttttgaattc ttcaagatcg 1183621 agacttgtat tttcagcaat ctccaaaagc acgttttcat ccgtaatatt tttctttgaa 1183681 acaaataggc tctcctgcat atttctgaga aattgcatgc cggcttttcg tccttgcagt 1183741 tcggctgctt taaaagcgag agcagccata taaggcgatg aaagcggctg atcctgttcg 1183801 aaccagacat tgccgtcaca tgacatgcca gagcggctcg cgatcttttc ccatgcttct 1183861 gcgagaagat gcttttttcg ctttttattt aaagcggtaa ggcttgcgga agcgataatg 1183921 cgtaaggtga aaaaacgtcc gtatctgatt ttcagctttt tgatgacggg ctctaaggac 1183981 cagcattcag gacataaagg gtctacaaac atataaattt caagcggttt ttttggatga 1184041 ccgtggcaat gggcgaagta tagctcatgc tgatagtttg tcaagatgat cgatcctccg 1184101 cttccgtttg attcaccata tgccttgctg tcaactccag ccggccaaac aaaaactcac 1184161 gaatttcgcc ctccagccct acatggtcca ttgcgtcctt catacagctg agccacgcat 1184221 cagctctctc gtttgtaatt ggaaagggaa gatgccttgc tctgagcata ggatggccgt 1184281 gttcctcagt ataaagagga ggcccgccta aatactgagt taagaattgc ttctgtttcc 1184341 tggcggtttc tgtcaaatcg cttggaaaaa tcggcttcag caaaggatga gacgcgacac 1184401 gctcataaaa agtatcaaca agttgcgata gaagttcctc tccaatcgct tcataaggtg 1184461 cgttaaacga ttgtcccatg ttgactactc ctttaaatat ggctaatagg aatcataaat 1184521 cctattgcaa aaagtaattt tctgtatttc attgtttcat ctagatttat tttagcaaca 1184581 aggcatcatt tctacaaaca aactgccttt tatgcgtttg atgactcatt tcggctgaca 1184641 gccggggttt gtatttcata tcatatcaca taaaaatcag gaatgcgtaa gatttcactt 1184701 cgcaaaaaaa ccagagggaa agagcacctc tggttacgcg taataaactg aagttatttt 1184761 ttttacatag ttttgcgttt cttggaaagg aggaatgcct ccgtatcggt caacattccc 1184821 cggtccggcg ttgtaagccg ctaatgccat agacacattg ccgtcgtatt tatccagcat 1184881 ttgttttaaa tatttcgttc cgccctccac attttgctgc ggatcaagcg gattggaaac 1184941 gccaagtgag cttgctgttg acggcatcag ctgcatgagg cccatcgcac ctgctccgct 1185001 gaccgctttt gcattaaagc ctgattcctg tttgatgacg gcgcggatca gtttttcatc 1185061 aacgccatat ttatcagcgg cttttttaat cgcactgtca atagagaagt ctcccgaacg 1185121 gatctgattt gcttcatgtt tgtttgaagc tgaatctgca acagctgttt cagtgctttc 1185181 tgccgctttt gtgactgaac ctgaattgct gctcgtatat gagttaagcc catacgctga 1185241 aagcagtgac ggcgctgttg tattcgcgct gttcagcatg ctgagcgggc ttggcgatga 1185301 agaaggtgct gattgctgag atgtcagacc gtttgtatat tggctgagca aagaactgaa 1185361 acttgaaagc gggctttccg tattctgagt gtccgagctg ctgcgtgcat tagatatgga 1185421 ctgtaatgcc tgaagctgaa gtaatgctgc ccaattcgtt acattcacga tgtcattcca 1185481 ccttatatag actttcgttt ttcttcataa aaacgcagaa ttttattttt ggtttcgcgc 1185541 tgaggaatgc tgaattgctg aagcagcttt tcgaaggctt gtctgccctc atgccaatcc 1185601 gccgcctcaa attcaatttc atagtcctct ttatttaaat atcggctgtg gtctaaaact 1185661 attaagcctt tttctgtttc tttttccgca cggtttgttg ctaaagatcc aaagtattgt 1185721 atggcatccg tatcgatctg aagcttgtgc agctggtcct tcacagggcc ctcgggaact 1185781 gaaaatccag cgagatctga tacctctgaa agctgctggt gcgtttccag aagccccaca 1185841 tcagccggct cctttaatgt aaggacatac tttccgtttt ttctgcggat acgaagcgca 1185901 gcatgttttt gtttcagcgc gaagctgtct gtatcaaaat aatgattctt ttgatctgta 1185961 aaatcttttt ctgtcagctg gagtgccgat gctatgtttt tgaattcttg tttggtcagc 1186021 atgtttttaa attcgatttc aatctcttgg ctcatgatgc tcttcctttc cgccctgtaa 1186081 atcttatttt tactattatc tctttagatg ttaggtttat caatatcgag ctcgatatga 1186141 taaaatgaat ctgtactttg tttaaaaaag gagagcatta tgcaaaacag aatcgaaatt 1186201 ttgaatgcaa cattatcgga tgatcagctt cgccttgcct gtcagacaga aggaaacgaa 1186261 gcggaacgca agccgtcagg tcaaatgctt gttgattctg accactttgc ttttgtatac 1186321 atacttgaat tagctgattc ttttgaatat gtcattataa aggaacatgt atggccggaa 1186381 ctgaagcagg cccatgcaca aaaaataccg gttgttttag aggcaggaga ccaaacaatt 1186441 gaactggcag gcctgcatga ggagctggaa tatcttttag aaaatataaa agataatgca 1186501 aactatggag aagaaatgga agaaaaagtg aaacgcgtgt ttttatagaa actggttcgg 1186561 aattggggga tgtatgatgg atgacaaaca atgggagcgt tttttagtgc cgtaccgcca 1186621 ggctgtcgaa gagttgaaag tgaagctcaa ggggatccgc acactatatg aatacgagga 1186681 cgaccattca ccgatcgaat ttgtgaccgg acgcgtcaag cctgtggcga gcatacttga 1186741 aaaagcgaga cggaaaagca taccgctgca tgaaattgaa accatgcagg acattgctgg 1186801 ccttagaatc atgtgccaat ttgtcgatga catccaaatc gtaaaagaga tgctttttgc 1186861 cagaaaagat ttcaccgttg tggatcagag ggattatatt gcggaacata aagagagcgg 1186921 ataccgatca taccatcttg ttgtgctgta ccctttgcag acggtatccg gagaaaagca 1186981 tgttctcgta gaaatacaga tccgtacact ggcgatgaat ttttgggcga ccattgaaca 1187041 ttcattgaat tataaataca gcggaaacat tcctgaaaaa gtaaaactaa ggcttcagcg 1187101 cgcttctgaa gcggcttccc ggcttgatga agagatgtcg gagatcaggg gtgaagtaca 1187161 ggaagctcaa gctgcctttt caagaaagaa aaaaggaagc gagcaacaat aggtaaaggg 1187221 gaagaagagc atgaaatttg ccgtatcatc aaaaggagat caagtttctg atacgctgaa 1187281 aagcaaaata caggcgtatt tattggattt tgatatggaa ctggatgaaa atgaaccgga 1187341 aatcgttatt tcagtcggag gcgacggaac gcttttgtat gcttttcaca gatacagcga 1187401 ccgtttggac aaaacagcat ttgtcggcgt tcacacaggt catctgggtt tttatgccga 1187461 ctgggttcct catgaaattg aaaaacttgt tcttgccatc gcgaaaacgc cgtatcatac 1187521 agtcgaatat ccgcttctcg aagtcattgt gacctatcac gaaaacgagc gggaagaaag 1187581 atacttagct ttgaatgaat gtacgattaa aagcatcgaa ggaagccttg ttgctgatgt 1187641 ggaaatcaaa gggcagctct ttgaaacctt ccggggcgac ggcctctgcc tgtcaactcc 1187701 atcaggcagc acagcctaca ataaggcgct gggcggagcg attatccatc cgtctatcag 1187761 ggcgatccag cttgcggaaa tggcttcaat taataaccgc gtgttccgta cggtcgggtc 1187821 acctctgctt ctcccatccc atcatgattg catgattaag ccgagaaacg aagttgactt 1187881 tcaagtgacg attgaccatt taacccttct ccataaggat gtaaagtcga tccgctgcca 1187941 agttgcatcc gaaaaagtgc ggtttgcgag attccgtccg tttccatttt ggaaaagagt 1188001 ccaggattcg tttattggaa aaggtgaata gaaagaggac atatcgtgga gcattttttt 1188061 atcagaaaga acattacttc cgctgaggac gggatgactg taaaagaata tgccggtgaa 1188121 ctgggaattt cgaaacgtct gctgaccgat attaagtttg gcgggggaga cctgcagatt 1188181 aacggtgagc atgtgacggt caaatacgtt ttgaaagagg gagatcttct tatcgtgaag 1188241 tttcctgagg agcaggtgag cgagacgctg ttggcagagc ctgttccgct cgatatcctt 1188301 tatgaggatg aacatgtgct tgtgataaac aagcagccgt atgtgtcatc aatcccttcg 1188361 agagagcacc cctccggcag cattgccaat ggaattattg atcattatca aacaaccgga 1188421 gtgagggcga cagttcatct tgtcacccgg ttagaccggg atacatcagg tatcatgctt 1188481 gttgccaagc atcgatttgc ccactccatt ttatcgtctg cgcaaaaaaa cggccttgtg 1188541 aaacgccggt atgcggcagt ggttcacggg cggatggcac agatggaggg aacagtcgat 1188601 gctccgattg gcagacatcc tgacagtatt attgaacgga cggtaacgcc agacggccag 1188661 aaggctgtta ctcattttta cgtcacatgt gcaaatgatg acatgacctc ggtggcattg 1188721 cagcttgaga ctggacgaac ccatcaaatt cgtgttcata tgagctatct cgggcacccg 1188781 ttgtgcggcg atacactgta cggcggaacg agacaggaaa ttggccggca ggctctgcac 1188841 agcgagcatc tttcgtttat ccatccgctg acacaggaga acatgaggtt tcatgctcca 1188901 ctgcctcagg acatgagcaa actgataaaa ggagagaatc attgattctc tcctttttta 1188961 tatggggcga aatcttgatt cgtcgtaagg cagggagctt ggaacagaga cggtttctat 1189021 ttctggaaag cgaaagcctg tcagttgatt tccgaacacg cagcctgtat caatgttgat 1189081 ggtgcgattg accttccgag gctctttcac aggtgtatga ccgtatacca cccaagcctt 1189141 tccgttatag gctgccgccc aatcacgcct gatgggtctg ccgtccggat atgtttcacc 1189201 cgtcacgtca ccgtaaagca caaagtcctt cactctgcgg gtatatttgc cgatatcgtc 1189261 agctcttatg ccagcatggg cgacaactaa ttctccatta tgtaagatgt cgtaaagcgg 1189321 cgctgtttcg tacagcttca taaactgttc gctgactgat tttttctcat ctttggaaag 1189381 ttcctcaagc tctgccgctg ttgtttcgag accatgcatc acttttaccg gatttccttt 1189441 taagtaacga tataatttat tgcaatggtt tcccgggaca taacgcacag cgcctttttc 1189501 gtaagcgccg gctacaaatc ggatgacctc tatcgatttg ggccctctgt cagttaaatc 1189561 tccggcaaaa acaagcaccc tgccttcttc atggacaggt actccatttt tgattgtata 1189621 gccaagcttt tggattaatg cagtcatttc gtcatagcag ccatgaatat cgctgatgat 1189681 atcgtaagcc atgcggtctc ctccttaccg attgttttat ttattatgaa gcaaagtgtt 1189741 gtgagtcatc acaagctttt atgtgcaaat tatagaagaa gaatcatttt ctaaacagga 1189801 ttaagacctt atcactttat ttttcatcat cacccttgtt aaaatcgcgt tatgtttttt 1189861 aaaaatgagg ttttgttctc tgagtgagaa ctagcataac cctgacttaa aaaggaggtt 1189921 ctgattatgg cgcatacatc tgtcgcatct ttagttgttg tacttatcgt tgcatttttg 1189981 acacccatcc ttttgcatcg gtttaaactc agcatcccgg ttgttgttgc tgaaatcatt 1190041 atggggctga taattgggaa aagcggcctt aatttagttg tggagggtga cacctggctc 1190101 cagacactct ctatgctcgg atttatcttt ttaatgtttt taagcgggct tgaaattgat 1190161 ttttcgtcgt ttgagaaagg aaagaaaaag cagttcctgc cgaatggcaa ggaagcgccg 1190221 aatacgtttg ctgcggcatc tgttattttc gtcggtattt ttattttatc attgctcttg 1190281 tcctatgggt tcgtcttggc cggatttatc caaaatgcat ttttgatgac cctgattatt 1190341 tcaacgattt cattaggcgt tgtcgttcca acattaaaag aagaacggat catgaattcg 1190401 aatatcgggc agattatttt gcttgttgct gttattgctg atttggccac gatgattctt 1190461 cttgctgttt tttcttcttt atacggagag gacagcggaa acatgtggct cctgatgatt 1190521 ctgtttgcgg ccggagtggt gctttacttt ttcggccggg tcttcaaaca tcgctctttt 1190581 gttcaatcca tgtcaaaagg gacgatccag atcgggacgc gtgccatttt tacgttaatc 1190641 attgtactcg ttgccctgtc tgaatcactt ggggcggaaa atattctcgg cgctttctta 1190701 gcgggggttc ttgtttccct gctttcgcca aacaaagaac ttgttcagca gctggactca 1190761 ttcggttatg ggttcttaat accgattttc ttcgtgatgg tcggtgtgaa gcttgatatt 1190821 tggactcttt tccaggataa aacaatttta atcatgattc cgctcctgct gcttgcgctg 1190881 ttagtcagca aaatcattcc tgtcatgtac ttaaagaagt ggtatgataa ccgaaccatt 1190941 ttcgcgtctg gtttcctgct gacatcaacg ctttcgctcg tgattgctgc tgcaacaatc 1191001 ggccagcagc ttcacgtgat cagtacaaat atgtcaggag cgctaatttt agtagccgtc 1191061 attgcaagta tttttacgcc gatctgtttt aaaaaattat acaaacggga agagcagccg 1191121 gaggagaaaa agacgattac gttcattggc gccaatcaaa tgactttgcc tgtcacactc 1191181 gaattgccag aggaagagta tgacgtgcgt gttgtacacg tctaccaaga gaatgcggag 1191241 gaaaagctgt cagaatcagt gtttgctgtt gaaacaattt ctgactatga acacgagacg 1191301 cttgaatcac tcggcatttt tgaaacggat atcctcgttg tggcgacagg aaatgaagat 1191361 atgaatgcag acattgcatt acttgcaaaa gataaaggca cagaaagagt cattgcaagc 1191421 gtaggatcac cggagcatga agcagctctg aaggagcagg gaatcagcat cttttctatt 1191481 ctgctgtcga caaaaacgct gcttcgcgca ctgattgaag cgcctggcgt catgaagctg 1191541 ctcacgaacc aagagtcttc gctgtatcaa attaatatgg agaacagtaa atatgatggt 1191601 gtcattttac gggaattccc tttaacaggt gacgtcatct ttgtcaggat cttcagaggt 1191661 gtggacagca tcgttcctca tggggatacg aggctgaaac ttggagaccg tttaattgtc 1191721 accggatctc gggggtacgt aacggatctt aagaaaacat tggaaggata aatcttgacc 1191781 aaataaggat tcgtgttaat atagaggtgc agaacaattc aatatgtatt cgtttaacca 1191841 ctaggggtgt ccttcataag ggctgagata aaagtgtgac ttttagaccc tcataacttg 1191901 aacaggttca gacctgcgta gggaagtgga gcggtatttg tgttatttta ctatgccaat 1191961 tccaaaccac ttttccttgc gggaaagtgg tttttttatt ttcagagggg gaatgatttg 1192021 tgaagttttc agaagaatgc cgcagtgcag ccgcagaatg gtgggagggg agctttgtcc 1192081 atccgttcgt tcaaggaatc ggtgacggaa cgcttccgat tgaccgtttt aaatactacg 1192141 tacttcagga ttcctattat ttaacgcatt ttgcaaaggt gcagtcattt ggtgccgctt 1192201 atgcgaagga tctttataca acggggcgga tggcaagcca tgcccaaggt acatatgagg 1192261 cggaaatggc gcttcatcgc gagtttgccg agctgttgga aatcagcgag gaagagcgta 1192321 aggcgtttaa gccgtctcct acggcgtact cttatacatc ccatatgtac cgttcggttt 1192381 tgagcgggaa tttcgcagaa atcttagcgg ccctgctgcc atgctattgg ctctattacg 1192441 aggttggtga gaaattgctg cattgtgatc cggggcatcc aatttatcag aagtggattg 1192501 gcacatatgg cggtgattgg tttagacaac aggtcgagga gcaaatcaac cgctttgatg 1192561 agctggcgga aaacagcacg gaggaagtgc gtgccaagat gaaagagaat tttgtcatct 1192621 ccagctacta tgaatatcaa ttttggggaa tggcctatcg aaaagaaggc tggtctgaca 1192681 gcgccataaa agaggtggag gaatgtggag cttcacgcca taacggatga cagcaagccg 1192741 gtagaagagc tagcgagaat catcattacg attcagaatg aagttgattt tattcacatt 1192801 cgggaacgct caaaatcggc ggcggatatt ttgaaactgc tcgatcttat ttttgaaggc 1192861 ggtatagata aacgaaaatt ggtgatgaac gggcgcgtgg atattgcact tttctctact 1192921 attcaccgcg tgcagctgcc aagcggcagc ttttcaccga agcagatcag agccagattt 1192981 ccacaccttc atatcgggag gtcggtgcat tcactggagg aagcggttca agcagaaaag 1193041 gaagacgcgg actacgtgct gttcggccat gtgtttgaaa cggattgcaa aaagggtctt 1193101 gaaggcagag gagtatcttt gctgtcagat atcaaacagc ggatttccat cccggttata 1193161 gccatcgggg ggatgacgcc ggacaggtta agagacgtaa aacaagcagg ggcagacggc 1193221 attgctgtta tgtcaggaat tttctcttcc gctgaacctt tggaagcagc cagacgatat 1193281 tcccgcaagc taaaggagat gcgctatgaa aaggcattat gaagcagtgg tgattggagg 1193341 cggaattatc ggttccgcaa ttgcttatta tttggcaaag gaaaacaaaa acaccgcatt 1193401 gtttgaaagc ggaacaatgg gcggcagaac gacaagtgcc gctgccggaa tgctgggcgc 1193461 ccatgccgaa tgcgaggaac gtgacgcgtt ttttgatttc gctatgcaca gtcagcgtct 1193521 gtacaaaggt cttggagaag agctttatgc attatccggt gtggatatca ggcagcataa 1193581 cggcggtatg tttaagcttg cattttctga agaagatgtg ctgcagctga gacagatgga 1193641 cgatttggac tctgtcagct ggtattcaaa agaagaggtg ttagaaaaag agccgtatgc 1193701 gtctggtgac atctttggtg catcttttat tcaggatgat gtgcatgtgg agccttattt 1193761 tgtttgcaag gcatatgtga aagcagcaaa aatgcttggg gcggagattt ttgagcatac 1193821 gcccgtcctg catgtcgaac gtgacggtga agccctgttc atcaagaccc ctagcggaga 1193881 cgtatgggct aatcatgttg tcgttgccag cggggtgtgg agcggaatgt tttttaaaca 1193941 gcttggactg aacaatgctt ttctccctgt aaaaggggag tgcctgtccg tttggaatga 1194001 tgatatcccg ctgacaaaaa cgctttacca tgatcactgc tatatcgtac cgagaaaaag 1194061 cggaagactg gttgtcggcg cgacaatgaa gccgggggac tggagtgaaa caccggatct 1194121 tggcggattg gaatctgtta tgaaaaaagc aaaaacgatg ctgccggcta tacagaatat 1194181 gaaggtggat cgtttttggg cgggactccg tccgggaaca aaggatggaa aaccgtacat 1194241 cggcagacat cctgaggaca gccgtatttt atttgcggct ggccatttca gaaacgggat 1194301 cctgcttgct cccgcaacgg gcgctttgat cagtgatctc atcatgaata aagaggtcaa 1194361 ccaagactgg ctgcacgcat tccgaattga tcgcaaggag gcggttcaga tatgatgcta 1194421 cagctgaacg gtaaagacgt gaagtggaaa aaagacacag gtacaattca agacctgctg 1194481 gcgtcgtatc agcttgaaaa taaaatcgtt atcgtggaaa gaaataaaga aataatcggg 1194541 aaagaacgct atcacgaggt tgagctttgt gatcgtgatg tcattgaaat tgtccatttt 1194601 gtaggaggcg gatgagcatg ttaacaattg gcggaaaatc atttcaatca agattgctgc 1194661 tgggcacggg gaaataccca tcgtttgaca ttcaaaagga agcagtagct gtttctgagt 1194721 ctgatatttt aacatttgct gtaaggagaa tgaacatttt tgaagcatct cagccgaatt 1194781 ttctggaaca gcttgattta tccaaatata cgcttttgcc gaatacagcg ggcgccagta 1194841 ctgctgaaga agcggttcgg attgcaaggc tggcgaaagc ttcaggcctt tgtgacatga 1194901 ttaaagttga agtcatcgga tgcagccgtt ccttgctgcc tgaccctgtt gagacattaa 1194961 aagcgtctga acagcttctt gaagaaggct ttattgtgct cccgtacacg tcggatgacg 1195021 ttgtgctggc gagaaagctg gaagagctcg gcgttcatgc catcatgccg ggtgcatctc 1195081 cgattggatc aggacaagga atcttaaatc ctttgaatct gtcgtttatt attgaacagg 1195141 cgaaagtacc ggtcatcgtg gatgcgggaa tcggctcgcc taaagatgcg gcatacgcaa 1195201 tggagcttgg agcggatggc gtactgctca atacggctgt atctggcgct gacgatcccg 1195261 tgaaaatggc tcgtgccatg aagctcgcag tggaagcagg gcgcctttct tatgaggcgg 1195321 gccgaatccc gcttaagcaa tacggaacgg caagcagtcc gggagaaggt cttcctgtat 1195381 gacaggcagg tattcaaggc aggagctgtt tgctccgatc ggcccatccg gccagaaaaa 1195441 attgaaagaa gcgcgcgccg tgattatcgg cgccggcgcg ctcggaacag ccagtgcaga 1195501 aatgctggtg agagcgggag tcggctctgt gaaaattgcc gacagagatt atgttgaatg 1195561 gagcaacctc cagcgccagc agctttatac agaagatgat gtcaaaaaag aaatgccgaa 1195621 agcagccgct gcggagcgcc gtctccgttc gattaacagc gatgttgatg tgaccggcct 1195681 tgtcatggat gtgacagcag aaaatatctt cgagctgatt agggatgcat cgattattgt 1195741 ggatgcggct gataattttg aaacccgcct gatcgtaaat gatgctgcgg taaaggaagg 1195801 gattcctttt ctttacggtg cctgtgtagg gagctacggt cttaccttta ccgtggtgcc 1195861 gggttctact ccttgcctgc attgcttgct cgatgcactt ccgattggcg gagcaacatg 1195921 tgacacagct ggcatcatca gtccggctgt tttgcaggta gcagtctttc aggtaacaga 1195981 tgcactgaaa ctgctgacgg gagaggagtg cgagccggtg ctgcgctcct ttgatttgtg 1196041 gaaaaacgag cggtcagaag tgagagcggc cagtctcaaa catgacgcat gcccaagctg 1196101 cggcacaaag gattttccgt ttttgtctta tgaaaatcaa acaaaagcgg ctgtattgtg 1196161 cggcaggaac acggtgcaga tcagatcatc tattacgaaa gaagcggatc ttgaagcgct 1196221 tgccggtcag ctgaggcagg ccgggcttga agtagctgcg aacccgtatt taatttcctg 1196281 ccgctcggat gatatgaaaa tggtgctgtt ccgggacggc agagctttga tccatggaac 1196341 aaatgatatt gcccgggcaa aatccattta tcataaatgg attgggtaat aaaaggagtg 1196401 tagtgtaatg agtatatata aagcattgac aatcgccgga tcagattcag gcggcggcgc 1196461 agggatacag gctgatatta aaacctttca agagcttgat gtattcggaa tgtctgcgat 1196521 tacggcggta accgctcaaa atacgcttgg cgttcacggg gtgcatccgc tgactgtaga 1196581 gacgttgaga cagcaaattg acgctgttgc tgaggatttg agaccggatg cagttaagac 1196641 gggaatgctc tggaatgccg acatgattga agaagtggca agaaaaattg acgagtacgg 1196701 attcaatcgt gtaattgttg atccggttat gatcgcaaag ggcggggcat ccttgctgcg 1196761 tgatgagtca gttgccacct taaaggagtt gctcattcca agaagctacg cgattacgcc 1196821 gaatgtcccg gaagcagaaa cgctgacagg aatgacaatc agctcgctgg atgaccggaa 1196881 aaaagcagcg gagcagctcg tcaagatggg tgcgcagcat gtcattatca aaggcgggca 1196941 ccagcctgag gacaatcaca ttactgacct tctttttgat ggcagcatgt ttatgcaaat 1197001 cacccatcct tatatcaata cgaagcatac gcatggcaca ggctgcacct ttgctgcggc 1197061 tttaacggcc caaacggcta aaggagacag catccatcag gcatttgagg ttgcggccaa 1197121 ctttgtccgt gaagcggtgg aaaatacgct cggcatcgga tcgggacacg ggccgacaaa 1197181 ccatttcgct tttaaacgaa acagcttaaa tacaagccga tgagatcacc agctgatggt 1197241 gatctctttt gcgtttgcta cggtatgcgc ttttcatctg gacaaggtta tgatatgata 1197301 ggaattaaga tcaggtacta atactatgtc tttattaaat ataggaggct ttatacatat 1197361 gaatttttca cttgaaggcc gtaacattgt tgtgatgggg gtagccaaca aacgcagcat 1197421 cgcctggggc attgcgcgtt ctttacatga agcgggtgca cgtttgattt tcacatacgc 1197481 tggtgaacgc ctggagaaat ccgttcacga gcttgccgga acattagacc gcaacgattc 1197541 catcatcctc ccttgcgatg ttacaaacga cgcagaaatc gaaacttgct tcgcaagcat 1197601 taaggagcag gtcggtgtaa tccacggtat cgcgcattgt atcgcgtttg ccaacaaaga 1197661 agagcttgtc ggcgagtact taaacacaaa tcgtgacggc ttccttttgg ctcataacat 1197721 cagctcatat tctctgactg ctgttgtcaa agcggcacgt ccgatgatga ctgaaggcgg 1197781 aagcattgtc actttgacgt accttggcgg agagcttgtg atgccaaact acaacgtcat 1197841 gggtgtagca aaagcttctc ttgatgcaag tgtgaaatat ttagctgctg acttaggaaa 1197901 agaaaatatc cgcgtcaaca gcatttctgc cggcccgatc agaacattat ctgctaaagg 1197961 catcagcgat ttcaactcta tcttaaaaga catcgaagag cgtgcaccgc ttcgccgcac 1198021 gacaacacct gaagaagtgg gcgatacagc tgcgttcttg ttcagcgata tgtcccgcgg 1198081 gattacaggt gaaaatcttc acgttgattc tggtttccat atcactgccc gctaagcagg 1198141 atctatatca agcaatcccg aatagggatt gcttttttat ttcttctgat tttcagcttt 1198201 ctgtcatata gatagaatat gacacaatcg gagggatgaa gatgtctaat aagaaaagaa 1198261 acgcggataa aaaaccgctc atgtatattg ttcagccgga ttatgcagaa actacaaggt 1198321 catccatgca ggagattgtc atcaaaagaa aggccgacaa acccgctccg ccaaaagctg 1198381 aggaaaagcc ggcttaccat gagaagcagc aggaggaagc cgtggcacag gatgtcctgc 1198441 aagaagacca aaagcctgca gccgaaccag tgagtcagca aacacaagag gcgagagagc 1198501 cagagaacat aaaaagccaa gaggaacaga aggcagagcc gcaggccgta gaagaaaccg 1198561 ttgaacacga gcccccgaaa gcagaaaaaa aggaagagcc tgcacttgag gcccggaagc 1198621 ctgagaaaga accggaagct gtccatagtg ctgataaagc ggaggaaaaa gcaccgccgg 1198681 cacgaaaagt gaaaaaaccg atgagcaaga tgacgatcca cgaaaaaatt gattttttaa 1198741 caaagctgcc tcataacatg ccgagagcgc tttgtttgat tgaagccaat ggaagaacgt 1198801 acaggggcgt gattgtcgga agaagaaatg attccgtcct gcttcgaaca accggaaacg 1198861 gagccccaac cgaactggca atcgatgata ttacctcttt gcacccgctc ggtttttaac 1198921 gaaaaagaaa aaagctgccc ggctgatgtt gccggacagc tttttttaca tagagaaaag 1198981 cctgcaggcc tgcaagcttt tccagcttat gattaatgat gatgtgtacg attgattaat 1199041 cgaggattta agcagttgat tgcgcagaag cagtctaagt caacttcaat acagtagttc 1199101 gttttttcga gtcggaacac ttcacacacc gtatctttat cggtgaagtc caaaatgtgt 1199161 ttgtgttcgt caaatgcgat taataatgac agtgttgcac agcttccatg cactctttcg 1199221 accctgaaaa atactgtatt aaagcaaggg ccgttatcga gttcgccgac atttccgaag 1199281 gcgactaatg gcgttgattt tgatgtaaat attgcaaaag gcactgtgtc gcctaacgaa 1199341 tggcttacag ataaaagctt agagtggcag ccggtcgggc agtcttcttc aacagcgttt 1199401 tgcagatctt caatattttc tacagcttca cgcacgcagc ttgatgtttt ctggctcata 1199461 ttatccctcc tgccttataa atttgagact ggcgaaatga tggagagtca gctgcctcac 1199521 gctggaagca gctgaatgat ttgcacctgt aatagagttt ggaaggggat tcctctttac 1199581 aagtgtttat ccattgtgat gatgcttttt atctttgtga ggcgatgttc tgtcaactag 1199641 ctctggtgac aggcactgaa tcgcgcagaa gcatccgaga tccacttcaa tgcagaaatc 1199701 tgttttttct agcccgaaga aatccgggtc gcaagggtgg caaacactta aggtatcgcc 1199761 tttgacatcg accgggcgta aaatagacag tgttgcacag caatcgcata atttttcgac 1199821 gcggaagaaa atggattcaa agcattgcat atcatccaca aatcccccta cgtttccgaa 1199881 tgtggagaac aatccgcctt ttttatcaaa aacgagaaac ggaattgtgt cttttccagc 1199941 aatcgtaggg tttaaaaggt tggtatagca gccagtcgga cactgttctt caactgcctc 1200001 ctgctctgct aaaatctttt ccactgcatc gcatacacag ttctcatgcc ggccatgggt 1200061 ttttccgcag ctcattgatt tcagctcctt ctttataggg tatttgactt tagtccttaa 1200121 caacatatgt acccgtgccc cacttggtgt gggtgaacgt ctatatattc atcatatgct 1200181 tggaaaataa gaaaaagcag agcgttttta gctctgcttt taggtcctag aggacaagag 1200241 tgataactag gatggctacg agtgtatttg ttgctgtaga aataagggtt gcgatatcgg 1200301 catctactgt tgtgacgttt acgccgcggg aacattcgat gagaagtttt tggcggttta 1200361 cttgtttgtt agctgtaagc tgtaacaaat cttgtgcgac taattcggca attacgccgt 1200421 ctgcaattga tgtcagagtt gccgttacga cagcggcatt aagtgctgtt acaactgatg 1200481 ttacggcttg aacgtctgta gatgtaacat tgatgtcaca agaatctcta ataataatcg 1200541 tttcatctga aacttgtttg ttgagatttg cttgagctag atcttggtcg atgaaggcgt 1200601 tgtcgttgcc aaaaaaacca ttgccattac agcaaacgtc gcaatgacat tttctttcgt 1200661 gtttttcttt atctttctct ttgtcatcta acggatggtc acagtcagga tcaagtgcaa 1200721 cccaagaata tggtctgctt tccatatcta ttcctccttt tcttttactg ttattaaatg 1200781 agcgagcctc ttattttgac tgagtcatat atcctgatga agaaccctat tttttatgat 1200841 tggctaattg ttatcgtttt tccgtctttg tctgatctgt tcaatgagct gctctctgcg 1200901 gcttaacggt tttgtgttct tttgctcttg tgcggctgct tcttcttttt tcttcttttg 1200961 gttttctatt agcgcttgtg atttagcttg taagtctttt acaagattta agagcatttc 1201021 tttttcttcg tctgatactt ttttcatttt gtcttttgtg accccatgtt tagaaaatat 1201081 attttggacc agcattttcg tcattggatc aacttctgga agctttgcaa gctcttcttt 1201141 gaatttatcg ttatctgaca tttgttttca cctcgtcttt taagtttgtg aaaagaaagg 1201201 gttaaaggac gtcaagttca ctaagaatgc tgtttaacac ctgaagcaag atttgtacaa 1201261 aggttattat ctcgtcggca gacaaagtaa ttttgatgtt gcggctgttg ataattttaa 1201321 tgatggttct ttttttgatt tgggagctat cgagaataag aatttcactt gccactgcgt 1201381 cagccaaatc ctcgtcggcg atgacgagct gagtcgccac gataatcatg gttgtcacaa 1201441 aggcttgtat agaaagggca gctgttatat gtgacgtgtc aattgtgata ttttcgcaat 1201501 caatcacttc gatctgctgt tcgaattcgc ttgataattg ctcaaatatt gcagggtgca 1201561 gggattcgac tttttcttca aatgacataa ccttcactcc tttcttatcc atactctata 1201621 taatgcaaat ggggtgcaga gcggaataat aaaaataacc aattttctgc cggacaagat 1201681 acaattcatg aagaataggg ttttggcata tatgtgaagg gatcatgatt ggcaaaggag 1201741 tgaacgagtg gttataaatg ggctgacaat tgttcttcta tcgcttgcgg tctttcggct 1201801 cgcccgcctg ctggtgtttg acacgattat ggcgccgctt cgcagtctgt ttcatgaaga 1201861 gaaggaagaa aaggatgcgg acgggaacat tgaaacctat atcgtgatta agggaaccgg 1201921 tgtcagggcg tttattggtg aattgctgag ctgctattgg tgcacaggcg tgtggtgtgc 1201981 cggctttttg attttatgcc aggcggtgat cccgcaagcg gcgcagtggc tgattttact 1202041 tttggcgatc gccggccttg ccggcattat agaaacgctc gtatcaaaat ggctgcaaga 1202101 ataaggcgtt accaccagca actttctgtc agaatacgca taaagtagca tatatgacat 1202161 aaggaaagga aggggacaaa aatgaatcag catcataaac cttcccaaaa atctccatat 1202221 acagattcat cgtatcaatc aaaaaagata aaaaagaaag gctgcgggtg cggaaataaa 1202281 aagaaaaagc ctcaatagcc tggcaaagaa accggagaac tccggttttt tgttttttta 1202341 acgaggcggt ctcgctcagc atatatcata agcgggggga taaaagtgaa tgagtttgaa 1202401 aaatggatag aaggaagata tgaaccacat gaacaaaagc aaaaagagca tgaagacacg 1202461 atgggcagta tcagaaaaga cttggatgca tttgataaag ccggtctgga atttgaagat 1202521 gagattgaag agctggctga aaaaacggag gccttactta aaaaacatca agctcaatat 1202581 gatcaatcgt aaatccgcaa acgccctatg cgaatatcca agccgatccc agcagctcac 1202641 atagtgtata gagagtaaag gaggtgctta tctatgggct ttggatacgg attcggcggc 1202701 ggctacggcg gcggctgtta tggcggttat gctggcggtt acggcggcgg ctatggttca 1202761 acatttgttt tgttggtcgt attattcatt ctcctcatca tcgtaggtgc atctttcttt 1202821 taagatgtat tgaggaagta cgggttataa cccgtacttc cttgccttgt gtttattttt 1202881 aaaaatgttg gaaaagcaca ttgtattatg tgcattcata caataccgta ttactccgcc 1202941 aaaaggaggc gcattatgga taatcaattt tttaagaaca tcgaaaagaa aacaggtgtg 1203001 aagatgcagg atgtaatgaa tcttgccgga tcactccaaa acgctaattt taaagatgaa 1203061 aatacagtgc gcagtgtgat taaccgcgta gcgcagatgg caaacagacg cgtgccaaaa 1203121 gaattagaag ataaaattgt ggaatctatt acaagcggaa aagaaaagct tgattttggc 1203181 acgatttcta aaatgatgga taataaataa gtggatggcc tggctgactc actgcagcgg 1203241 gccttttttt acagtaaaaa cccggcagta atctgccggg ctgttaatga tgcaagggct 1203301 gtcttgcttt ctgtagcagg ggatacaaaa atcttgagcg gttggctgtt ttgccgcgcc 1203361 tgttagcagg gcaagacaaa tataaatgct gtttcgcccg ggtcatggct acatataaaa 1203421 ggcgtctttc ctcctcaaga gcggcctcgt ctccttttct tgccgtttct aatgagaaat 1203481 cgtgcggaat cgagccatct acagtgccta acacgtagac tgttttgaat tcaaggcctt 1203541 ttgaccggtg aatggtcatc agctgaacgc catgttcatc cgttctgttt ttctcagcgg 1203601 ccctcatatg gtctacgtgg gcaagaaagt caggaatcgt tttgaacttc ttggcgacaa 1203661 ccttgatgtc gcgcaggtca tcagagcctt tttccagctt gttgccctca ttgccccgct 1203721 tttttaaata ctcggagaag cccatttttc cttctgcaaa ggtgatggct tctacgggtt 1203781 tcattgtgcg gaggcttgca aaaaacggta cgattttctt gattttgtcc agctggaatg 1203841 gcttcagatc aggcaatttg gccagcgctt tgatcatggt acagtcctct gtaatcgaga 1203901 gcgccttcag cgtattcaaa gcggactgtt ttaaaaacaa ggcgggaagc aagtgtttaa 1203961 tcgcctcggt gtcatcctca ttttggctgg cgtacaagta ggcgagaatc tggcggacga 1204021 tccgtctgct gtaaaacgat tggacgccgc ggtcagctgt atacggaatt gacgattgat 1204081 gaagcctttc atatatagca cggcctccgc tgtttgtgcg gtaaagaacc gcaaagtctt 1204141 ctggactggc tccattttga attttttctt tgatatcgga aacgaccatt gtggcttctt 1204201 cctcttcatc ataaggataa aacagcacag ggacctgaat gtcatcgcgg gccgcttcaa 1204261 gcgttttggc atatctgttt ttgttctttt tcacaacgat atcagcacta gagacgatcg 1204321 ggtgcgtaga cctgtagttc gcagttaaat agatcgtctt cgctcccgga taatcctttt 1204381 gaaaatcaag aatgaaagac ggattgcttc cgcgaaacgc gtagatggac tggtcatcgt 1204441 ctccgacaca gcacaggttt tgctccgggc tggcgagcat ttgcatgatt ttgtattgaa 1204501 ccggattaat gtcctgaaac tcatcaatta agatatacgt aaaccgagat tgatattgtt 1204561 ccagaaggtc aggccgctcg ataaacaatt catagcaggc tgaagccatg tcatcaaaat 1204621 caaattggct gtgttctttt ttctggcgtt cataatgttc atataaacga taaacttgtt 1204681 tttcccactc atcttttaga gggatgcgtt catttgggac ataagtgttt ttccaaaaac 1204741 cgatctgctg cagggcttgg tcaactgggg attctttctc atcgatgcct tcttcataga 1204801 gtgctttttt gatatattgt tcccgctgcc actccatttt cagcagatgc tcaccgttcc 1204861 atttagcaga attagagtga tacaagatct tataaaacag actgtggaat gttcctgtca 1204921 caattcttct gacttttgcc ggctgtaatc cgtactggtt cgccatacgc tctttcattt 1204981 cagcgacagc ttttgttgta aaggtgacaa gcagcatatt ttcaggcggt atgcctaagt 1205041 gttcgatcat gtgggcggca cgggctgtca gtacccgtgt ttttccgctc cccgcacctg 1205101 caagcacgag gagcgggccc tctgtttccg tgacagcttt cagctgatcc gtgtttaaac 1205161 cgacagacgg aaaaaggctc gtatcgggtt ctattgtttt tggcacaaat ggtgttcctg 1205221 gtttaatgct tctaggacgg tgccattctg taacagctgg ggacgggtca gcggcgatcg 1205281 cttttccctt gggtaaacga atgacaccag attcctgatc atcttctttt ttcccctctt 1205341 tagagggctt cggttcgcac gcctcctcac atgccggaaa atcgcctggc tggcgatgga 1205401 taaactctgg cggatcggcg atgttaagcc gtaacaaaac gggctttccg caatgagaac 1205461 aaaataaatg tccttttatt ccctcttcaa agaggaattg ataatgttct ctcgaatatg 1205521 tatgtaaatg tatgattcta tcattcagtc gggcgcattt caaaaagggg tcctcccaat 1205581 caaaaggtgt tcattacaga caatgactat catatcaaaa gaaatgtgtt tcaaaaagta 1205641 agtttaaggg aaaagagaca gcagaggggt gggtattgta tgatatatgc aggtcaaatt 1205701 cagaaccagc aatacgctca atatgctaat agaacgattg gacataagca ggattatgcc 1205761 ggaaccgaaa aaatcagcta tgtcccgttt cagcgggtat acaaagaact ggaaaagcag 1205821 caggagaatc aaacggcagc tgaaagaaaa gtaaacgaga tgaaacgtaa gcgctctctt 1205881 tataagagat tgcgagaaaa aggaatgggg acatatatta atcgatatgt ataaaaaacc 1205941 gttcatacca gagaacggtt tttttatatg cagtaaaaat ccggatctca aaagatccgg 1206001 atgcgttcag tccttcatca tttgtaagtg cggaatgccg gcatcgagga attctttttc 1206061 agaaagcacg cgatacccgt gtttcttgta aaacggcaca gcctgtgttt gcgcgtttaa 1206121 aatgaaaccg gaagcgcctc cgtctgccgc ggctttttcg agcgctttca taatgatgcc 1206181 gccgacaccg gctgagcggt ggcttttcag tacgcaaatc cgctctaact tgccgtagcc 1206241 gtccttcatg cgccatcttc cggcaccgac aggcttttca ccgtcataca cgacgatatg 1206301 ctctgactca ttttcaagtt cgtcaatttc ttcttcagca ggcacgtttt gttctttgac 1206361 aaagacttct tctcttacat agaatgcatc tttcagttgt tcttcatttt ttgcgataac 1206421 tgctttcaaa cattattctc ctctgcctag caagaaggtt tcatatactg tccacgatcc 1206481 gttttccaac tggtagagca agtggaaacg gtcaacgatt tcttcatgcg acacttcctg 1206541 catttttaat tgtcccagca catctgaatg ctcatcgtcg gaaagatttt ggccgaccgt 1206601 cacatgcgga acgaaattat attcctgttc tcctgccaac acaccggtgt atagcttttc 1206661 attgagtgtt tttaactctt ccgtcggttc tgctttgatg taaatgacat tattgacagg 1206721 cgcaaatgag ctgtattttg tcattttgag aacgagtggg tgggactctt ttgcgatgtt 1206781 tcttaaatgt gatacgagct gatccgcttt ctcctccgcg cattcaaagg atgctctcag 1206841 cgtcaaatga ggcgggatta gagagtagct tgggtcatag cgctttctgt aagagtttgc 1206901 aaggtcttgg agcttttttg atggaaataa aacgattccg tatttcatat tatgtccctc 1206961 ctggaaataa agtatgatag agtgttaaag catttttttc agcgccgggg tgatgagcgg 1207021 ctgccagtat gtccatttgt ggtctccgtc aaatggctcg aaatcataat cggaaagctt 1207081 tttctccagc agctgtttca gctcccggtt cggttctgta aagtccagaa tgttcccgtc 1207141 tgtcgtgtgg acgtcagttt cttttgttcc gatttggtga taaatagaga ggtgtttgat 1207201 atcgtctgac tgttttacgg cttctagtac gtgtttgtca acatagggag actgcatgat 1207261 gatgttgcca aacatattcg gataatcaag cgctgtcata agtgacacgg ttgctccgag 1207321 cgaatcaccg atcagcgttc ggccgtaacc gatctgatag gttggatact catcatctgc 1207381 aaaaggaacg agctcatggg cgatgaaccg tttataagcc gaaaattttg aaccctccgg 1207441 atgataagtg tttctgcgct cttttacatc cttataggga acaccgataa taatgctccg 1207501 gtctatttcg cgtttcgaca gcaattcctc aacctgtctg ccgattctcc ccagcctgaa 1207561 ataatcgtgg ccgtcctgcg cgataatgac atggtattta taaagcgggg agtagttgga 1207621 cggcagataa acaagcaagg tcatttcctc gttaagctct tttgaaaaga atttcttttc 1207681 ttgcactgtg ccgtttttcg gtgccataaa aacattcctc caggacatca ctatactttc 1207741 ttgcattttc aattattgta ccatgaatta ttagaaattt ctctctttaa acggttcggc 1207801 acacgaagaa aaaagtgttg aaataaactg tgaattgcgc taatataaaa caatcagaaa 1207861 attgaaatcg atatttctta tcgtgagagg tggagggact ggcccttaga aacctcagca 1207921 accggcttgt tttgcatttg caaagcgcca aggtgctaaa tccagcaagc gttttttatg 1207981 cttggaagat aagaagaagc gttaaacccc ttcttcttat gaagaagggg tttttatttt 1208041 gaaaagggaa ggtgtcagct atatgtcaca gcacgttgaa acgaaattag ctcaaattgg 1208101 gaaccgtagc gatgaagtca cgggaacagt gagtgctcct atctatttat caacagcata 1208161 ccgccacaga gggatcggag aatctaccgg atttgattat gtccgcacaa aaaatccgac 1208221 acgccagctt gttgaggacg cgatcgctaa cttagaaaac ggcgcgagag ggcttgcctt 1208281 tagttcggga atggctgcta tccaaacgat tatggcgctg tttaaaagcg gagatgaact 1208341 gatcgtttca tcggacctat atggcggcac gtaccgttta tttgaaaatg aatggaaaaa 1208401 atacggattg acttttcatt atgatgattt cagcgatgag gactgtttac gctctaagat 1208461 tacgccgaat acaaaagcgg tgtttgtgga aacgccgaca aaccccctca tgcaggaggc 1208521 ggacattgaa catattgccc ggattacaaa ggagcacggt cttctgctga tcgtagataa 1208581 tacattttat acaccggtct tgcagcggcc gcttgagctg ggagctgaca ttgtcattca 1208641 cagcgcaacc aagtatttag gcgggcataa cgatctgctt gctggacttg tcgtggtgaa 1208701 ggatgagcgg ctcggagagg aaatgtttca gcatcaaaat gcaatcggcg ccgtcctgcc 1208761 gccatttgat tcgtggcttc tgatgagagg aatgaagacg ctgagcctca gaatgcgcca 1208821 gcatcaggca aacgcgcagg agcttgcggc gtttttagaa gagcaggaag aaatttcgga 1208881 tgtgctgtat cccggaaaag gcggcatgct gtccttccgt ctgcaaaaag aagaatgggt 1208941 caatccgttt ttaaaagcac tgaagaccat ttgttttgca gaaagcctcg gcggggtgga 1209001 aagctttatt acataccctg cgacccagac gcacatggat attcctgaag agatccgcat 1209061 cgcaaacggg gtgtgcaatc ggttgctgcg cttttctgtc ggtattgaac atgcggaaga 1209121 tttaaaagag gatctaaaac aggcattatg tcaggtcaaa gagggagctg tttcatttga 1209181 gtaaacacaa ttggacgctg gaaacccagc tcgtgcacaa tccatttaaa acagacggcg 1209241 gaaccggggc agtcagtgta ccgattcagc acgcctcgac ttttcaccaa tcttcatttg 1209301 aagagttcgg ggcatatgat tacagccgct ctggcacgcc gacaagaaca gctctcgaag 1209361 aaacaattgc cgcactggaa ggcggaacaa gaggatttgc tttcagttca ggcatggctg 1209421 ccatctcaac agcattttta ctgctgtcac agggtgatca cgttcttgtg acagaagatg 1209481 tatacggcgg aaccttccgt atggtgacag aggtgctgac ccggtttggc attgagcata 1209541 cgtttgtcga catgacggat cgtaatgaag tggcgcggag catcaagccg aacacaaagg 1209601 tcatttatat ggagacgcca tcaaatccga cacttgggat tacggatatt aaagcagttg 1209661 ttcagcttgc aaaagaaaac ggctgcctga cctttctgga caatacattc atgacgccgg 1209721 cactgcagcg tccgcttgat ctcggcgtgg atattgtact tcacagcgcg acaaaattct 1209781 taagcggaca cagcgatgtg ctctcaggtt tggctgctgt caaagatgaa gagcttggga 1209841 agcagctgta taagctacaa aacgcgttcg gcgccgtcct tggcgtgcaa gattgctggc 1209901 ttgtcctgcg cggattaaaa acattgcagg tccgtttaga gaaagcgagt caaacagctc 1209961 agcggcttgc ggaatttttc cagaagcacc cggcggtcaa gcgcgtgtat tatccgggac 1210021 tggctgatca tcccggcgct gaaacccata aaagccagtc aacgggagcg ggcgccgtgc 1210081 tatcttttga gcttgaaagc aaagaggccg ttaagaagtt agtcgagaat gtgtcactcc 1210141 cagtcttcgc tgtcagcctt ggcgccgtgg aatcgatttt gtcctatccg gcaacgatgt 1210201 ctcatgcggc aatgcctaag gaagagcgtg aaaaacgcgg tatcactgat ggcctgctcc 1210261 gtctgagtgt cggcgtcgaa catgcagacg atttagaaca cgatttcgaa caagcgctga 1210321 aagaaattgc tccagtttcg gttcgttaaa aaagaagccg gggatagtcc ggcttctttt 1210381 attattgttc gtcatcagga ttcagaatcg cgaggacttg atgatcctcc caaacgccat 1210441 taatttttac attttttcgg gcgatgcctt ctttatgaaa tcccgctttt tctaaaacac 1210501 gcatggaccc gagattacgg ggcatcacac cggcttcaat ccgatgcagt ttcaattcgt 1210561 ggaacgcata atcaacaacc aatctgactg cctctgtcat aatgcccttt ccattatggg 1210621 ctttgtctaa aaaatacccg atgaacgcag tttgcagcgc gccacggatg atttgaaaga 1210681 gcgaaaccgt cccgattaat ctatcgtctg acgctgtaaa gatgccaaaa tgatattctt 1210741 catctttctc aagtctttcc tgatactcgg ttattcgttt tctttgcccc tcaaccgtat 1210801 agtaatcgtc tgcgcgtatc atagaaaact gttcgaaaaa atctcgattt tcgctttgca 1210861 gccccagatt ttcttcggca tccgttactt ctaaaggtct aacataaatg gtttttcctt 1210921 ttaacatata gtgatctctc cgttctcatg tcagcattcc tcttacatta ttctcaggga 1210981 aatgcaaata tcctttttat aagaaggaag aaaaccaatt tcccataaaa gtgccaacat 1211041 agttgccgat taagtagccg agcgtaccga caagcatgat cggggcgaca agctcccgcc 1211101 atcccttggc aattgccatc gcagccgcag tcgtcggtcc cccgacagta gcgttgacgg 1211161 cgagcagaat ttcttcaagc cgcacacgga acaattttcc ggcagctaag gaaaccgcta 1211221 aattgctaat cgcaatgata aacacgaata atagaataag aggcgcattc gtgacgatta 1211281 agcggagatc tgcaggaatg ccgatcacca caaaaaacaa ataaatcaaa aaggttccaa 1211341 gctcctgaga tccattgagc ctttcaaaaa aacgcgggaa aagaaaaatg ataagaacag 1211401 ttaaagacgt aagaaccagg tactgatcgc caagcgtacc ggtcagcagg ggatgagaaa 1211461 aaatgctttt aaaataaccg gaaaccttca tactaaccgc aacaagcgcg aaagcggcac 1211521 cggcattaaa agcgatatcc tttaaggaaa tatccttccg tttccaatag ctttcagcac 1211581 tgtttccgct gtttccatcg gcttttacct tctcttcaaa cggcatggca taatgccgct 1211641 gaaaccattt gagtgcagga atgctgatta aaataaaaaa caaaagcgcc atcataaaat 1211701 tatcagccac aacggtagcc gacacatatt caccaggcgt ctcaaatttt gccgccatcg 1211761 ccgcaaagtt gaccccgccg ccgatataag aggcgctgat catcccaccg attttatcta 1211821 agtaaggaat atgctgtttg agtagaaaaa aagccaggat actgccaagc actgttccaa 1211881 cggagctaat cagaaaaata aacagcaaac gcctgctttc cttaaaaatt tgcctaacat 1211941 tgatctgaaa caataaaagt ggtatcgcca gcggtaccac ataagaccac acagtgtcat 1212001 acacgggcga ctcaacagga agcactccta catttgtaaa caccatagca cctgcaaggg 1212061 cgataatagc gcccgacaca gcagacgccc acttaaagcg ctgctccagc ccgatgctca 1212121 ctgccgccca caccgcaata aacccccata atacccatac atcatcagaa gaaatcaaag 1212181 aatgcaaaac cccatcacct ctattgttag aaaattaaga catattataa tagccgggga 1212241 acggaacagc aagtccaaaa aaagtttttc taaaaaagca gttgacgaat agaaggtaag 1212301 gttatataat agaacttgtc agaaagataa caacataccc agcaacacat acatatcatg 1212361 attccgtagc tcagctggga gagcgctacc ttgacagggt agaggtcgct ggttcgagcc 1212421 cagtcggaat catagcttaa acccttgcgc agcaagggtt ttttactttg cgttaataaa 1212481 gccggttcgt caaattcgtg agttgttggc gaactgttgg cgaaattcat tgaccgcagt 1212541 ccaaaaacta cctccaaact tacttgatta gttcaatagt aacaaacgga agatcggatt 1212601 tctgttaaat cttcattgag aatagccagt ccaagaccgt cacttcagcc atgcatcttt 1212661 taaatgaaat tttgtactga aaacatcaat tgtattttta aattctgctc tagaatcagc 1212721 ccctttataa taatcttgat aaattgcttg gggtgatact gattcgtgat ttgtgctatg 1212781 gtttgcaagg cttgtagcaa aagcaggagc aacagtaacg agtaaagcaa gggataatgc 1212841 aaaaccagtt aaagcttttt caatttcatt ttaagcactt ctttttttaa aatacaactt 1212901 tattattaaa tggaatacaa aaacatccaa ggtgtttttt tgttagtaag ttgagttagg 1212961 gggattggat ggcacttaga atattgtttc tgctgatggg atgttgattc tggatatatt 1213021 tccaacacga ttacaggccg gacatgaaag cgaaccttgc tttgatcggg gcaatcattt 1213081 catttacggc tgcggtttac tttaaagata ttgatgtatt gagagaagag ggaaaacaaa 1213141 tgaacggaat ttctgagcgt tggaacacgt ttaaattaca aaaatcccct gaaccactct 1213201 agatcagggg attgctttcc caacagctta ttaagtagcg gaaggcatga tcaacgattt 1213261 agtatcaatt tattaattgc gaatactaga aacataccgt tttccgcctt ccttagaagt 1213321 aacatattct cgaggaacat taagtctatt ggtagaatga taacttacat aaagtttcat 1213381 atttgctcgg ctcgttacga tagccgtatg atccatccaa ccatcagcat agcgaagacc 1213441 tattttatta tggtaatcat agtgatatac atctccaagc tttacatttg aatatgtatc 1213501 agaaacagtc ttcattttta ttccgccagc ttttaaaatg tatgatctaa aggctcctgc 1213561 attaacccaa gcatctgtat agggtttcca ttctttaaag tacggcattc ttccagctct 1213621 taatgcttgg gaaacaaagt tagtacaatc tttgtcttta taatatttat agtttttatt 1213681 tggttttaag gcatattttt ctgcatattt cattgcagcg taaccactat atcctttaac 1213741 agatgttgca gtcacagtta gttgattaga gttagcagca ttgaagttca tacttactgg 1213801 tttatcttca cttttcactt cttctttatc atcatttttc acttcttgct tatatttttt 1213861 taaaaattca tctaatttaa catccgaaga atattcttca tcattttcat attgtagagt 1213921 tgaagaagaa ttatttaatt gtgttacatt tagttgctta gaagaattac tcaatggtat 1213981 tacatttagt tgattagaag aatttttaac ttgagagaaa cttagattag aagtatttgt 1214041 tgattgagaa ctttgtttat tagaagttgt tttgggaatt tcaagtttaa tattatcgcc 1214101 cagagatgtt gttacttttt caacaccaaa aacaaagttt cgagtaatat aagcttcaac 1214161 aattagctta ttgttttttt cagaagtctt aacatcgtct atatcgtatg taaactcgtg 1214221 gaatttttgt ttgtccactt tacttaacgc agaatacagt aagactcctt cgtcggaatc 1214281 agtcaattta gactctttag gatgcgctaa aggagtgttg tgttcaaaat catatttttg 1214341 ttgttctaac atatccttaa ctttttcgta accaatctcg ttggtaattg aaacattttc 1214401 tttagtctct ttattagtag tggctgcaaa aacttcattt gttgacacta atggtgacaa 1214461 tgatagacat aaaactagtg aagcaagtaa ttcttttttc atacgaaacc tccaataaaa 1214521 tctaaatata agtaatattt atcatttaca ccaattgaaa tatggcataa aatacatgta 1214581 ataatataac ataaaaataa atacataaaa aggtatcgga ggaaaaaatg aaaaagaaaa 1214641 ctaaaattat actttctctc ttggcagcac ttattgttat attgatagta cttccagttc 1214701 tatctcctgt tgtctttaca gcttcttcgg aaaaaggagc aatcagacac gaaatttata 1214761 aaagaggata tccctaccaa agctactttg cagttctcca gaaaagagaa ggagacaatg 1214821 aatctgggaa tctttattat gtaaattggc tagattggaa agatgaaaca gggcaaactc 1214881 ctcacttatg ctattcgaaa aaatcatcag atggtgaata cgaagtaagt tgtggcacag 1214941 ggccgtaaaa ataaatttta aaattgaata agtccaagac ggaaagcctg cggacactga 1215001 tcgttttaca gagaaatttg tgcttcgatc ggtgtccgtt ttttttcgca actaaccaga 1215061 tgtctatcgc gattactagc tatgaaagga gtaattagac atgaaacagt ccaaaaagaa 1215121 accatcacag aagcaacatg agcgcttaga tcgtttctgg caacaaatga tgaacactaa 1215181 catgcaaaca ctcagacgtg gcaaaggcgg cgcttataaa cgcagaaagt aaaaagggag 1215241 tttgaggatg atgaaaaacg gattcgctta taaaaacgga aagcttgtga atatcttttg 1215301 cggcaaagaa gagctctata acgagttgaa agccttcttg gtcaaaacct tcagtatcaa 1215361 cgtgaaagag gtatcgaggc cctcaatata tcgcagaaca aaaagcaaac aactggaatg 1215421 acacttactc tatttaacta tcaggaggga aagcactatg acagatcaaa tgattgcatg 1215481 ggagattgag gaatggattc gtgattataa attcatgctg cgggagatca aaaggctcaa 1215541 ccgtgtatta aacaaagtgg attttattag cacaaagctc actgcaacat acggggagga 1215601 agcgggcatg ccaaggggat cagcaggcgt cagtcaggca gaattgcggc agatggaccg 1215661 aagagaaagg cggcttcaca aatatgaatc tattgtgcat tacctggaca atgcaatgga 1215721 acacattgaa gaagaaaagc accgaatcgt ttacgattgc atgatggaag gcatgagcta 1215781 cactgctatt gcaaaccacc ttgattgctc ccgggatacc atcagaaaga tcaaaacagc 1215841 cataatcggc aacatcgtca ataaagtcaa agaagccaac tttctgcaat atttgaattc 1215901 gtttaaatcg gcggtgtaaa atggggggca ggatcggcgc ggcggattat tcctgcgtca 1215961 ccaccaattt catacaatga gtaaaacctc ccagtggtaa gcgaggatca actcaactgg 1216021 gaggtcttac atagtgaatc ggtgataaaa cagcagcagt attgcgtaca tgttaatatc 1216081 cccgacaaaa tatgtttttt tcaacagatt cgttcgacaa attttgcaaa ttgttaatcg 1216141 ataacttttc attcccgata ttaaaaatgg gagtgaattg taaaatgaaa aaacagaaaa 1216201 ataataaaaa gaagaatatt gaaaagcgaa atattgaaaa gcgaaatatt gaagagaaga 1216261 ataatgagga cttagaagaa ctggaaaatg cgatttatac ttatcacaaa aaggagctac 1216321 ttgctttctt tcttgaaaaa actcgaattg gtcatgataa ggaagaatac aaaaggttcc 1216381 aatctcttct ttataagttg gatattgaat gtttagaatt tgctatatcg agattttctc 1216441 atatagatat tatccatgat cattcaaaat atgttccagc ctttatccct ttatttgcag 1216501 catatctcac catgttcttt aatttttatg aaaaacattg gggagcttta tcttttgctg 1216561 ctggtacaat tgctgctatt gtttggataa ttgcagtaga aagaaaacat agaaatcaag 1216621 caatttctat tatgaaaata tttgaacaag tcaaagagag aaaagtgaaa gacagatcta 1216681 aagactgaaa ggagaaaata tgaataagga taaattaagg tatgcaatct taaaagaaat 1216741 ttttgaaggt aatacccctt tgtcagaaaa cgatattgga gttactgaag atcaatttga 1216801 tgatgctgtg aactttttaa aacgcgaagg gtatatcatt ggggtccatt attcagatga 1216861 tagacctcat ttatacaaat taggacctga actgacagag aaaggtgaaa actacttgaa 1216921 agagaatgga acatggtcta aggcctataa gaccattaaa gagattaaag attggattaa 1216981 ataataagag catcctgcgg ggtgcttttt ttgttccctg taaactgctt ccggtaagtc 1217041 tcaggataga caattggcgg ttaacggctt gagcacggtg gtggtttaga gggaatatct 1217101 tttccaaaac aacacgaatc agaagggggc ggcggtgaat gtagatggcc gaaaagcaca 1217161 ttcaggcgta taaggattac gtcaaaggca tgaaatacaa ggaccttgcc gagaaatacg 1217221 gggtgtcagt gaacaccatt aaatcgtgga agcagcggca tggttgggaa aggaaaaagg 1217281 gtgcacccat tgaaaaaagt gtgcacacaa aaaaaggcgg gcaaccgggc aacaaaaatg 1217341 cattagggaa caatggcggc gcaccacaga agaatcaaaa tgctgtgact cacggctttt 1217401 tctctaaatt cttgccagaa gagacgcttg aaatcatgga agagattcag gagcgttcgc 1217461 cagctgatat gatatgggat cagatacaga ttcaatatgc ggccattctt cgggcgcaaa 1217521 agatcatgtt cgtttctgat aaggaagaaa tgatcaaaga gctgaaaaag aaaaggtccc 1217581 tcatatctga ggtcagcgaa attgaagatg ggcttgtcat tagttttagt acgtggtttc 1217641 gctacagact ttacagtgaa acaaacacct aacacatttc acattgcttc agattgcctt 1217701 caaacttgat aatataactt ctaaaccttc ctataaaatg aaggtttttt atttgatttc 1217761 aatttttaaa tcctttacat acagcgattg attaactcga gcaatcaatg tcgcagttat 1217821 atttattttt caagaaaatg ttataatgaa aagccataaa atgatgggag ggggaatttc 1217881 gatgcattac ataacggcat gtttaaaaat catcagtgat aaagacctta atgagataat 1217941 gaaggaattc aaaaaacttg aggaagaaac gaacaaagaa gagggttgta ttacattcca 1218001 tgcttatccg cttgagccat cagaacgtaa aataatgctt tgggagattt gggaaaacga 1218061 agaagctgtg aaaatccatt tcacaaaaaa acacacaata gacgttcaaa aacaagaatt 1218121 aacggaagta gaatggttaa tgaaaagcaa tgtgaatgat tgaaaggctc tttaaaaaga 1218181 gacattcaat gacttagtat cagccacttg tgactaagta gtaaattgtt gtccaactct 1218241 tattttttct atttaatatt ttttgagacg aaaatgtttt tttaagctga ttttaaaatg 1218301 tattcaaagt cagctctgtt tgatttaatg gattatatta tttggatagc ttgttaccat 1218361 cataatggag atactcctta taaattggag gttaaaataa tgagtcattc tcaagaaaaa 1218421 attgcactaa ttacaggagc aagcagtcaa ggggatattg gtacggctat ttgtcgtaag 1218481 ttagcctcac agggtataca tatcttcttt actcactgga attctgatac ggcctggata 1218541 gaagaatttc aacaagaaat tttacgtatg ggtgtccgct gtgaggcaat gaaaattgat 1218601 ttatcagatg cacatgctgc attcacaata catgaaaaaa tttcagataa attaggatat 1218661 ccttccatcc ttattaataa tgcagctcat tccgcaagtg ataattatgt atcgttagat 1218721 gctaaatcac ttgatgagca ttatgcggtt aatatgagat cgaattttct tctttgtgtt 1218781 gaattcgccc gtcggtttaa aaaatctaat ttaatatcag gaagaatcat caatatgaca 1218841 tcagggcagg atttaggtcc tttgcctggg gagttagcgt atgcagcaac taaaggagct 1218901 atttctgcat ttactaggtc gttatcacaa gaacttgcac cattgggcat cactgttaac 1218961 gccgtaaacc caggtccaac agattctaca tggatgacag atgaaataag aaattttctt 1219021 tcacctaaat ttccaatggg gcgtattggc acaccagatg atgcagcacg aatgattgcc 1219081 tttcttgcaa gtgatgaggc tgaatggata actggacaaa ttattcattc agaaggtgga 1219141 tttattcggg gctaagctaa tgaaacacgg tatacaccaa tgtatgatgt attcccaaaa 1219201 ctaaatctaa acttgaagcg aaaataaggt cccttctctt tttagagggg gaccttattt 1219261 tattcatgca tgttttgcat ccagaaaatc tggcggataa agattaataa accgttacat 1219321 atacttttcc gaatactgca gtacctttaa acaaagtaat cgtggctttc ccttttgatt 1219381 tagccgtcac taaaccattt tgatcgactt cagcaacttt ttggttatca gtccaataac 1219441 gagtagctga attattttta acagaatagg tttctccaac ttttagaggt aaattatagt 1219501 cttgaatctt gataacatgt gtaggtgaaa tagaaatgtt ctttacttca gtaggtgtgg 1219561 agtttatttc atgagctgaa gctaccccgc tgaccgacag agctaacgca gaaatcgata 1219621 aagcagaaac aaccgttttt ttgaaattca ttttgaaaca ctcctttaaa gttttttgtc 1219681 ttgcactata acaattcaat aaaagtaatt attttccttg taaataaatg ttaataatat 1219741 gtgaacgatc aattgatttg agctaagaat attgtgtgcc ctgcacagag tttgtattta 1219801 tgatggaaaa ttgctgagag agaatggcca tccttaaaat gttaatagca cacatttgat 1219861 gggtattagt ttgttgagcg tgtggaaatt ttgttacctg cactttatcc ccgaagatac 1219921 caaatcactt ttcttcatca tgttcttact ttcgtactca tacattagaa aatcttcgtt 1219981 ctaaataggt gaagaattgg agtattttta tgaatttctg ctgaatatac attacatagc 1220041 aaactcaaag agtataaaaa tcgctttttt ccggaagctt cggtaaaaaa cgaaactttt 1220101 gtctctatga ttttgtttta taatgtaaac ggtttcttat atagtatact tatactatca 1220161 atttgctcaa gtagatactg acaggaagga tagaaaaaca gatggaatac ataaatacaa 1220221 gacaaaaaga gattttgtat ctgttgttat ctgaacctga tgactattta gttgtgcaag 1220281 atttcgcaga tagggtacag tgttctgaaa aaacaatccg gaatgatttg aaagtgatcg 1220341 aggattatct caatgagcat tctcatgcac agcttattcg aaaaccaggg ttgggcgttt 1220401 atttacatat agaagaacag gaaaggacct ggctaagcca acaattacat actgaacatt 1220461 tttcttctag gcagcggagc gataaggaaa gaatgctgca cattgcttat gacttattaa 1220521 tgaatccgaa gcctgtttcc gcaaaagaca ttgccgctcg gcattttgtc aatcgatctt 1220581 ccattaaaaa ggatttatac gcagtagaag agtggctgaa gcgttttgat ctcacactgg 1220641 tttctaggca gcggcttgga ttaaaggttg aagggaacga aagaaataaa agaaaggcat 1220701 tggcaagaat atctgatttg attcacaata cagcgtttac cagccaattt attaaaagta 1220761 agtttttaca ttatgaagta gactttgtga cgaaagaaat caaatcacta caaaaaaagc 1220821 attccctcta tttcacagac gaaacgtttg aaagtttgtt gctgcataca ttgttaatgg 1220881 tccgccgcat caaaatgaag cagccgattt cattgtcccc aaaagaaatg gcggcagtaa 1220941 aaaagaagaa agaatatcaa tggacatttg cttgtttaca gcggcttgaa ccggtttttg 1221001 caattcgctt ccctgaagaa gaagccgtgt acttaacatt acatatattg ggcggtaagg 1221061 ttcgttatcc attgcagaca gaagagaacc ttgaaaatgc tgtgcttcct aaggttgtag 1221121 ggcatttaat caatcgtgtt tcagagctga aaatgatgga ttttcacaag gatcaggatt 1221181 tgatcaatgg tttgaacatt catctcaata ctgtgctaca acggctgagc tacgatcttt 1221241 ctgtagcaaa tcctatgctc aatgacatca aaaagatgta cccttatttg ttccacctca 1221301 tcattgatgt tttggaagac atcaatcaaa cttttgatct tcatattcct gaggaagagg 1221361 cagcatattt gacattgcat tttcaggcag cgatcgaacg gatgcagggc agcagcgaga 1221421 cacataaaaa ggcggttatc gtctgccaca tggggattgg gatgtcacaa ttgctgcgga 1221481 caaaaattga acggaaatat caccaaatcg ctgtaatggc ttgtattgca aaggccgatt 1221541 taaaggatta tatcaaaaag catgaggata ttgatcttgt catatccacc attgcgctgg 1221601 agaatataac ggttccccat attgttgtgt ctccgctttt agagcctggc gaagagaaga 1221661 aattaagtgc gtttatacgt cagctgggcg aatcacaccg ccaaaaacaa aaaacgtttc 1221721 agatgctgaa caatacgact ccttttttgg tttttttgca gcaggaggcg gagcatcgct 1221781 acaagttaat cgaacagctg gcgacagctt tgtttgagaa aggctatgtt gataaggact 1221841 atgcggttca tgcggtgatg agggaaaaaa tgtcggctac aaatattggg tcaggcattg 1221901 ccattcctca tgcaaacgct aaatttatta aacaatcagc aatcgcgatt gccacattaa 1221961 aggagccgct tgaatgggga aatgaaaaag tttcgctcgt ttttatgctg gctgtcaaac 1222021 acgaggatca aactatgaca aagcagctgt ttagcgagct ttcatatctt agcgagcagc 1222081 cggccttcgt ccagaagctg acgaaagaaa ccaatgtcat gacattttta tctcatttgg 1222141 attattaaaa gcagggatta ttccttgctt tttttgttat agggaaaaat gcctttatta 1222201 ccggaaccta tggtaaaaaa agcgatttta atgagctgat ttcggtatac agttgagaca 1222261 agatcttatt attcacactt taaaggaggt ttcctatgaa actgttagcg attacatctt 1222321 gtccgaatgg aatcgcccat acgtatatgg cagcagaaaa tctgcaaaaa gctgctgaca 1222381 gactgggcgt tagcatcaaa gttgagaccc agggagggat tggtgttgaa aataagctaa 1222441 ccgaagagga aattcgcgaa gcggacgcaa tcattattgc tgcagaccgt tcggtaaaca 1222501 aagaccggtt tataggcaaa aaactgctgt ctgtgggggt acaggacggt atccgcaaac 1222561 cggaagaatt gattcaaaaa gctcttaacg gggatatacc ggtctatcgt tccgctacaa 1222621 aatcggaatc cggtaatcat caggagaaga aacaaaatcc aatttaccgt catttaatga 1222681 acggcgtttc atttatggtt cctttcattg ttgtcggcgg attattgata gcggttgcat 1222741 taacgcttgg aggggagaaa acacctaaag gcttagttat tccggatgat tccttctgga 1222801 aaacgattga acagatcggc agtgcttcat tttcatttat gattccgatt ttagccggct 1222861 atatcgccta tagcatcgct gataaaccgg ggcttgtgcc aggtatgatc ggcggttata 1222921 ttgcggcgac tggaagtttt tatgacagcg caagcggcgc cggattcctc ggggggatta 1222981 ttgccgggtt tttggccgga tacgcggcac tttggatcaa aaaattaaaa gttccaaaag 1223041 ccatccagcc gattatgccg attattatta ttccggtgtt tgcatcactg attgtaggtt 1223101 tagcgtttgt gtttttgatc ggcgcgcctg tagctcaaat tttcgcctct ttaacagttt 1223161 ggctggcggg gatgaaaggg tcgagctcga tccttctggc attgatttta ggggcgatga 1223221 tctcatttga tatgggcggt cccgtaaata aggtggcgtt tctgtttgga tcggcaatga 1223281 ttggagaagg aaattatgaa attatgggac caattgctgt cgccatttgt atccccccga 1223341 ttggccttgg cattgcgacg tttttaggaa aaagaaaatt cgaggcatct caaagagaaa 1223401 tggggaaagc ggcatttacg atggggctct tcggcattac tgaaggagcg attccatttg 1223461 cggcgcagga ccctctgcgc gttattccaa gtattatggc aggctcaatg acaggttctg 1223521 tgatagccat gattggcaat gtgggagaca gagtggcgca cggcggacct atcgttgcag 1223581 tgcttggcgc agttgatcat gtcttgatgt tttttattgc tgtgattgca ggatctcttg 1223641 tcactgctct gttcgtcaat gtactaaaaa aggatattac ggcgtctcct gtgctcagtg 1223701 aaactgcacc gacctccgcg ccaagtgaag ctgcggcagc aaatgaaata aagcagccaa 1223761 ttcaaagcca aaaagctgag atgtcggaat ttaaaaaact gacagacatt atcagcccgg 1223821 aattaattga accaaattta tcgggggaaa cgagtgatga catcatagat gaattgattc 1223881 agaaattgtc acgaagaggt gcgctgcttt cagagagcgg gtttaaacaa gccattttga 1223941 atcgtgaaca acagggaaca acggcgattg gcatgaatat cgcgattccg cacggaaagt 1224001 ctgaggcggt cagggagccg agtgttgcct ttgggatcaa acgatcaggc gttgattgga 1224061 atagcctgga tggatcagaa gctaaattaa tctttatgat tgctgtaccg aaagagagcg 1224121 ggggaaacca gcatctcaaa atactgcaga tgctatctcg aaagctaatg gatgacaatt 1224181 atagggagcg gctgctctcc gtgcaaacaa cagaagaagc atacaagctg ctagaagaaa 1224241 tcgaataaag cgggggattt tcatgacgac tgaaccgtta tttttcaagc ctgttttcaa 1224301 agaaagaatt tggggcggga ccgctttagc tgattttggc tataccattc cgtcacaacg 1224361 aacaggggag tgctgggctt ttgccgcgca tcaaaatggt caaagcgttg ttcaaaacgg 1224421 aatgtataag gggttcacgc tcagcgaatt atgggaacat cacagacatt tattcggaca 1224481 gcttgaaggg gaccgtttcc ctctgcttac aaaaatatta gatgctgacc aggacttatc 1224541 tgttcaggtg catccgaatg atgaatatgc caacatacat gaaaacggtg agcttggaaa 1224601 aacagaatgc tggtacatta ttgattgcca aaaagatgcc gagattattt atggccacaa 1224661 tgcaacaaca aaggaagaac taactaccat gatagagcgt ggagaatggg atgagctctt 1224721 gcgccgtgta aaggtaaagc cgggggattt tttctatgtg ccaagcggta ctgttcatgc 1224781 gattggaaaa ggaattcttg ctttggagac gcagcagaac tcagacacaa cctacagatt 1224841 atatgattat gaccgaaaag atgcagaagg caagctgcgc gagcttcatc tgaaaaagag 1224901 cattgaagtg atagaggtcc cgtctattcc agaacggcat acagttcacc atgaacaaat 1224961 tgaggatttg cttacaacga cattgattga atgcgcttac ttttcggtgg ggaaatggaa 1225021 cttatcagga tcagcaagct taaagcagca aaaaccattc cttcttatca gtgtgattga 1225081 aggggagggc cgtatgatct ctggtgagta tgtctatcct ttcaaaaaag gagatcatat 1225141 gttgctgcct tacggtcttg gagaatttaa actcgaagga tatgcagaat gtatcgtctc 1225201 ccatctgtaa catggcaggg cttgagaaat aaatttgcga gtgaagacgc ctattctcca 1225261 gcaatgatct aaataaaata agagtttaat agttggagaa gaaatgttac actcttttct 1225321 gtatatggta aagaatgaaa aaacacgatt cggttggtag tccggatgca tgattgagaa 1225381 tgtcagtaac cttcccctcc tcgggatgtc catcattctt taatatcttt tatgaggagg 1225441 gaatcgttat gaaattaacg atttactacg atggtcagtt ttgggtaggc gttgttgaag 1225501 ttgtggacaa tggaaagcta agagcctttc gtcatctttt tggcaaagag ccgagggatt 1225561 ctgaagtatt agagtttgtt cataaccaac ttttgaatat gatggcccaa gctgagcagg 1225621 aaggagtgcg tttacaaggc aggcgtcaaa aaaagatcaa tccaaaaaga ttgcagcgcc 1225681 aggtttcaaa agagttgaaa aacgccggag taacttctaa agctcaagag gcgataaagc 1225741 tagagcttga agcaagaaag caaaagaaaa aacaaataat gaaagaacaa cgagaacatg 1225801 taaaagagca aaggtatatg ctcaaaaagc aaaaagcgaa aaagaagcac agaggtaaat 1225861 aatccaaaca aaagcaggcg cagtgcctgc ttttgtaatt aaggactcta ctttgtaaca 1225921 tatatccaat gtttatactc cgctgattta tgattcaata taaaccctaa cttctccaag 1225981 gttttttgtg agcctagatt atcatgttcg catcttgcgg tgatccggga tactgtttct 1226041 cggcttaatg cccagtttat tagtttttgg gcggcttcca cacaataacc tttgcggcga 1226101 tgacttttat ttgttgcaaa accgatttca atcatgccat tttcgtctgg gtcacctaaa 1226161 aatccagttc ccccaacaat ttcataattg tccttcttta caataatcca tgaatcaaat 1226221 ccttttgttc cattgttttt gactaaaatc tcgcggaaat aaggtatcgc ttcaaaaaaa 1226281 tcagaatttg gccattcacc atttgtttca tagcctaatt ctttgatagc ctgatgatct 1226341 tgtttagacg cggcgtcaag aaggggaata tcaatcgttt gtaatcgtaa tcgattcgtt 1226401 tcaaggagaa ccatatattt aatcctcttt tctttttact gggaataatg ataacatata 1226461 acaattttct ctggtacctt ggcagtagag aaagatgaaa aaattgaggg ggattgaaag 1226521 agtgacaggt gagagtttgc ccagaccaaa aacgggtagg aaaatgctga tgttaatgtg 1226581 tccctacccg tttttctgtt cctgaatgca gggtttctga taacatgttg tgctaccttt 1226641 tcgcaatcaa ataaagcgat atggctcttt gggtttgcac aggattatga atgataatga 1226701 cccattggtt tcttcgtctt ggaaagcttg ctaccgcata caatggagca gtatcgcgcg 1226761 gagtgaaccc accatttatc acgttgatat ctcttccttc aagatgacaa actaagtatt 1226821 cacctggatt gatgacctgt tggttcgtcc atgcgtaaga ataaaagccg tctccaagat 1226881 cttcggtgga agatgggggg acaaagccat ctacagtcaa tgtgatttct cttcttcgct 1226941 gtctttctga aaagtctgga cttctttgag ggttatgagt atgtgaaaag taaggaatta 1227001 acgcagggcc ataaaagtaa tgatacaaag caaccactcc tttattttcc attcatacaa 1227061 attgtatgtg ggagttattt gttcattcct gttttgttcc atgtagacta ataatgggct 1227121 ataggcgtcc aaggaaatca atttgtcctt ccgttgattc aatgctagta accttgaaaa 1227181 tgcaggttag gatgatagaa tttacatatt actgcaagaa gttagacata catcattttg 1227241 atagtgggtg aaaacaatgg cgaaaaaaat ggcaaaaaca aatgcggttc gtctgataga 1227301 acagcagaac atctcttatg aggtattagg gtataaaaca gacggccagc cggtagatgg 1227361 catctctgtt gcggaaaaaa tcggttattc tttgaaatat gtatataaaa cgttggttgc 1227421 agcagcagga acaaatcatt attatgtctt tgttgtaccc gttgcagaag agttagatgt 1227481 aaaaaaggca gcaaaggtga caggggaaaa gaaaatagaa atgattgcaa tgaaggagct 1227541 gttagcggta actggctatc ttcgcggcgg ctgctcgcca attggcatga aaaaattgtt 1227601 cccgacctat attgatgcat ctgcagaaac gcttgatttt attattgtca gtgcagggaa 1227661 aatcggtatg cagctaaagt tggcgccaca agatttagcc agatcatgtg atgccgcatt 1227721 tgcagaaatt gtatagatgc agatataggg gaacgaaaaa gcttagtcat atcgattaag 1227781 ctttttccgc atccctttca aatatgattt caaaataagc agctgcccca tacccatcta 1227841 tactgggagc gaaaatctga acgaatctcc agcctctttt cgcataatca tggatgattt 1227901 gctggtagtc ttctttaggc cttcttctca tcgtactcag ctcaactctt acgaattcat 1227961 attctttcat cgtttgatcc ctcctattaa ggtatacgta aaatggagcg agaagttccg 1228021 aaaacctagg ttaaggtcgg aaagtatatt tcactcacta aacaaatcca tttatgcctg 1228081 atgcctgcat gcatctggga agagttaagg ggctataaaa acgaatttta ccgggtcagc 1228141 agtccaaatg aatctcttgc ttattgcatt tgactgagta tataagtaaa aaaagagcgg 1228201 ccagaacata taagaaggag atgatcatta acgcactcat aacagggtag tgtttagcgg 1228261 agtagatgaa aaaatcaagc tgtgaaattt gtttggggct gctgacggca tcaattccat 1228321 taagcagttt tgagagttta gcagtatagt tccaatcaaa tcgatctgaa acaagctcgc 1228381 ttccttgata ccaattaaca gcagctaaaa acagaaatac cataatagaa aatccaagct 1228441 gaacaactaa aaatattccc ttcacttttg tatgacctcc aaatctatga atatgggaaa 1228501 atcaaacaat atattaccac cgtatgggtt attcttgcaa tttcacttcc atacaactca 1228561 aacgcaagtc tatttttttg tttgtttttg gcttataata cctgatgatg gaaaaagagt 1228621 gcgggtttat agattagaga aacaaatgta tttcttagca ttttttattt gtggagagag 1228681 tatagaagca ttcgattaga tctgcttttt cacagaaacg gttttcatct gtttgcctga 1228741 gctttacaat tggctggcaa aaaaacaatg atttctttca atcaaaacat gcaacgatgc 1228801 gacacatttt atatcttgat gacttatttc attgccttta agtcatccta tcgagaaagc 1228861 gatggtattt tatgaacaaa gaaaccctaa aaaacatact catgattttt tcaatatgcg 1228921 caacactccg agaaaccgat ggtatgcgca tagctgatag ctggattttg agtgagatta 1228981 tacgattttt gatttgcatg gttgtgtttt ttgccatgac atttctatta gatgctgttt 1229041 ttccaaacaa aaaagagtca cattaatgtg tggctctttt tgcatcatct gatcagaaac 1229101 atcataaatg aatcgatcat catgatgaag aacagcaagc aaaaataaat aagcgagtag 1229161 acaaacatat cctttgccca cttcacgtca tcgtctgttt tgaatccttt gatgcttttt 1229221 ttgatccata tgcctccgag aaccaaggcg gctaagaaat aaaatgggct tatatggccg 1229281 gtgccgagag agaaaggaaa taatagcgtg accggcacca ggacggcaat atattgcatc 1229341 atttttattt ttgttacatg attgcctttg actactggca agagcggaac gccagcagcg 1229401 cgatattcct ctttgcgtct tatcccaatc gcccaaaaat gcggcggctg ccacagaaac 1229461 ataatcgtgt acaacagcac tgctgtcata ctgaagtcac cggttacggc acaatacccc 1229521 atcaatggcg gcgcagctcc tgggaagctc ccgacaaatg tgctccacac agacgttcgt 1229581 ttcacccata ccgtatagat gatcgcataa aaaataaagg cggccagtcc gagaaaggcc 1229641 gttaatggat tgagggaata aagcatggca agacctgcga ttcctaaaac agagccatat 1229701 gttaagatca tggctggcgg cattttccct gtgaccgagg ccctgctgcg agttcgtgcc 1229761 atttttgcgt ccatatgccg atcaaaatag ttgttataga cagtgccgga agccatcaca 1229821 aacgcggttc ccaacattgc tgttaccatt gtcatcaaaa aagccaagcc ggttaacgtt 1229881 ttttctgcgc ttgcaaacgc gatccaaaac ccgccgaagg ctgctatcga gtttgatatg 1229941 ataatgcccg gctttgcaag tttgataaaa tcgtaaatgg ttacccggtt cgaagctttt 1230001 atgtattttg tttcagatat ggctgcagaa tctcttgtat tctccaaaaa tagacgcctc 1230061 ccccaaaact gcatgctttt gttatcgtaa caagaggggg acagaatcac aattatttcc 1230121 catatttgtc atgatattgt catttttaaa acaaaaaaat ggggagctgg actgccccca 1230181 ttttgatatg tggcgactag taaccgtaac ctcccccata tcctccgcca taacctccgc 1230241 cgtaaccgta ccaagggtag taaggcggtc gcgggcgcgg gtagtaataa ggcgggcgcg 1230301 gataaaacgg gtagaacgga taatacggtc ttggataata ataaggcgga taaaatggcg 1230361 gtctcggacg cggataataa taaggctgtc tttcatcata aggggtaatt tgttcaaatg 1230421 actgttcatt caaagggtaa tccaagagga aaacctccct agcttttttt attcctttta 1230481 ccatattcct gatgcttaag ttgggtgtat gtacattcat gaaattcggt tttttttatg 1230541 atgaaattcc ttaaaaagga ttgacatgaa cttctaaatc tcatagtatt acaaatgtga 1230601 aataaatgtt actacaatgt tacaaaaaca tttctaaata gatacagttc caactgatga 1230661 agagtaaatc gaaatggcta cgaaagaagg agtttttgtt gttggcaaaa agaatcaaat 1230721 ggtttcatgt attaatagca gttgtatgtg tggtgggcct tatcggcttt ttccataatc 1230781 attcattgaa aaaagaaacg gtcatgaata aagtaagaac tgattctcaa tatgggaatg 1230841 ttgagatcgc aacgcttgtg aatgacggga aaacttttaa ttacgcggta aactatcctg 1230901 ttttcaaaaa tgaaaaaatg gattcggcat taaaaagatt cgcagaaaaa gaggttcgtc 1230961 aatttcaaaa ggaaacaaag gacgttgacc aagagcatac gacaaaacgc aacgaattaa 1231021 atgttgatta taaaattgtc cattatgcca aacagacagt ggcgattgta tttaatgaat 1231081 ataaatacat cggcggggca cacgggcaaa ccgtgaaaaa aacgtttaac tatgatttta 1231141 gtaaacaagc gtttctttcc attgatgata ttttcaaaga ggacgctgac tacttacata 1231201 agctttcgtt aatcgcttat cacgagctga aaaagaataa ggacattgcc gcggacgatg 1231261 cactgttaaa ggaagggacg gctccgaaaa aagaaaattt cagccgcttt gccatcaagg 1231321 aggattatat cgaactttac tttgacacat atcaggttgc agcaggctat cttggagagc 1231381 aatcgattgc cattaagaaa agtcttttga aagacattct gaaagaacaa tatattgata 1231441 aagcaaaaaa taaaaataaa atcaaagaac aaaagccgaa gcatgaagtg atttctttac 1231501 ccaaagagga aacagttgat ccaaatcaaa aagtcattgc gcttactttc gacgacggcc 1231561 cgaatcctgc gacaacaaat cagattctag actccttgaa gaaatataag ggtcatgcca 1231621 cgttttttgt tttggggagc agagttcaat attatccgga aacgctaata agaatgctga 1231681 aagaaggaaa tgaggttggg aaccattcat ggagccatcc gcttctcaca aggctttcag 1231741 tgaaagaagc gttaaagcag atcaatgata cgcaagacat cattgaaaaa ataagcggat 1231801 atcgtccgac gcttgtaaga cccccatacg gcggcattaa tgatgaactg cggagtcaaa 1231861 tgaaaatgga tgttgcgtta tgggatgttg acccggaaga ttggaaagac cgtaacaaaa 1231921 aaacaattgt tgaccgtgtc atgaatcagg cgggagatgg aagaaccatt ttgattcacg 1231981 atatttaccg cacctctgct gatgcggccg atgaaattat aaaaaagctc accgatcaag 1232041 gctatcaatt ggtgacagtt tctcagcttg aagaggttaa aaaacaaaga gaagcgaaat 1232101 aaattagaaa aggctgtccg tacggacagc cttttttcta tttaataaga gcctgtggtg 1232161 gcccaaacat ttaagtttgg tcctgaatac ttgccgaaag cgtaagaagt ccttggatct 1232221 aaatcatata ccatcggtgt atagcaagac ttttggccgg ccaccgcttt tccattgccg 1232281 cctgcagaat cacaattata tctttttccg tctgtgttcc gggtaatctc cgcatttgct 1232341 tcatagccag acgtcaatgt attattcatc gtgatttttg cccaagccgt tttacatgta 1232401 ctgctgaatt taagctcgac tactccgatg acttgattgc tggcattcac taagtttgag 1232461 gatttttttg tagagccgct ggacgcacaa tcattgtaat aagggctttt tccatcgtag 1232521 gcatgggttt ccgccttggc gggtgcacct ttgacggcaa aaacaaatac tactgcgaat 1232581 aacaccaatg aagccttcat aaacagtctt ttcaatttat gacctcctta atatggcaaa 1232641 caataaatca tatggaggaa caatcaaaac atgcatgctt ttttgtgaac aataaaggcg 1232701 gccgggagga tggagttctt ggccgcctct ggtatgaggt tatgctttta catcaatggt 1232761 ttgtccgaga gttggatgtt gaatcatctt taaggtttga tcggcatttt gctgggcggt 1232821 gtccagcctt tttttcgtta aagcaatatt tacattctgg gcaagggatg cttgatgcat 1232881 cgcaaccgat aaagcaggaa tatccatggt tccacctcct atgccttacc tatcggcggg 1232941 tttgtatgat tttacagtga aaaatggctt aatttctctt gttgaccctt acgctgcggc 1233001 atatcgtatg tttttgacaa ggagggaatc aggatgaatc tagtaatgga aaagaccttt 1233061 gagcaatacg aaaagctgtt ttcaatggaa gaacagaaaa gagaagatgt atttcggtat 1233121 acgatgatga ggccgtttga aaagatgtgg accgccatcc aagttccgct gaaagcgaag 1233181 gagccaaacg gctatgatgt gatcatggct gcgaaaatgc tgggctattt ggatgtccgt 1233241 gatgctgaaa gcggccagaa agcactacaa atactgaaag aatcacatgt ttcagagaca 1233301 gctgaatctg cacttcggca atgcatattt tttgctgagc gcgaacagct gcgggtgaat 1233361 gcaaaggaga tcaaattcgg cctttatatc gctgatccaa ataagcttca gctgcaaaaa 1233421 ggctactgcg ggtttggcgg gataccgggc tttattcatg tatggattaa tccgaacagt 1233481 tataacctgc caaggattcc ttccattatt gctcatgagt ttcatcataa tgtgcggttt 1233541 tcgtatatag attttcatca tggctctgta agtgtcgggg attatcttgt gattgaagga 1233601 ttggcggaat cattcgccag agagctgttt ggtacggaac gattgggccc ttgggtaact 1233661 cgttttgatc atgaagactt gcaatattcc attgatgtga ttaatgaggt gctggatgtg 1233721 aaaggatttt cggaagtcag ccgttatatg tttggtgatc caattgctaa cgaccaaggc 1233781 tttaagcctg caggtttatc ggcttttgcg ggttatgcag ttggctatca tgccgttcag 1233841 tcatttatga atcaacatca tatcacgata agcgaggcca cacgtttgga tgcgaagacc 1233901 attatttctc aatgcggtct gttttctaca tgaaaaaagc gtcacataca gcggcgcttt 1233961 ttgattccca aaaccagcag ttctatggcg gcacaggcgg caattccgat tgtatatgct 1234021 tcgatatcgc tccataaaaa accgtaccct agtacaagcc cgccaagaga agtatctcta 1234081 atctggtcga tccattcggc atgatagagc tggctgaatt caatgacaaa acagaaagaa 1234141 agactgataa tgcccgttat cattgtcttc agcttccgaa atagaaatcc gcatcccgtg 1234201 aagatcatgg cggcccacaa cgagtctccc agataagtat tgagggtatc aggaagaaca 1234261 ctggagaatg ctctggatcc aagccccagc ccaatgatca gtatggtgaa aactgcatat 1234321 atccaacgat ttcgcttcat tgcgaattga taccccgtct ctgcttcatc tccctgtatt 1234381 gtaaggaata tagcttttat ttgtccacta aaaaagcggc tgaatagccg cgtagggtgt 1234441 ttattttgct tttaggttta catggtcggc tgtctgatcc gtgcctatta caaaatggag 1234501 ttcatagcgg cctgtatcat atacataatc gatttcatcg gtaaacggga cggttaacac 1234561 ccgatttact ggtcctaatt gcttctgcag cacttccggc gtaactccgc ctaaattcag 1234621 ctgccgttcc acaccggttc caaagtagcg gatttctgaa attgtcatgt ctttatgata 1234681 ggaaaatccg tagcccggct gtcccatatt ccagtgatat aaatcaaatc gattgtctcc 1234741 cccgactggt ctttccggtt ccccaaacgc agcgtggaca tccccttttg tgcttttgtt 1234801 aatggtaagg ccttgcgcct gctgaggcat ttccccttta taggcggtgt tatagaggtt 1234861 tttgacaagc tcagcggctg attgattcgt gttttctgag agtgtgtttg tttgagctgc 1234921 ggcctttgcc ggtgctgaaa aggacgcagc cccaaagccg gtaaaacagc ttgttactgc 1234981 tgctgccgcg gttatagcag acattgtctt tttcatgtta atccctccta attgatctac 1235041 cattccgttt ccccgtgttt ttgcaacgaa acatgtgagt gcgctttgta tgttttattg 1235101 agttgttgta agggaactga aataggtaat tcggtatata aagcaagaaa ggggaatgga 1235161 gatggctggc aagaaaacaa tcacaataaa cggcgttgaa atggaagcgt ccgaggaaca 1235221 gacggtgctg cagcttttga ataacagctc gattgaagtg ccgcaagttt gctatcatcc 1235281 aagcttaggg ccgattgaga catgtgatac gtgcatcgtc agcatcaatg gtgagctgaa 1235341 gaggtcgtgc tccgctgaat taaaggatgg ggatgtcatt gatacgctct cacctgacgt 1235401 gaaaaaagcg caggtcatcg ggatggacaa gattttatat aatcatgagc tttattgtac 1235461 agtttgcgat tacaacaatg ggggatgcga aatacataat acggtgaagg aaatgaaaat 1235521 caatcaccaa agcattccgt ttgatcacaa gccataccat aaggatgaat cccatccgtt 1235581 ttatcggtat gatccagatc aatgtatatt gtgcggacgc tgtgttgagg catgccaaga 1235641 cgttcaggta actgaaacgc tgaccattga ctgggagcgg aaacgcccgc gcgtcatttg 1235701 ggataacgac gtgccgatca atgagtcgtc atgtgtgtca tgcggccatt gttcaacggt 1235761 ctgtccgtgc aacgcgatga tggaaaaagg aatggaaggg gaagccggat atttaacagg 1235821 catcaataac gaaacgctgc gaccgatgat cgagatcacg aaaggcgtag agacaggcta 1235881 cggctcgatt ctcgcgattt ctgatatgga atcggccatg cgtgatgaac gaatcaaaaa 1235941 aacgaaaacc gtctgcacgt attgcggcgt cggctgcagc tttgatgtct ggacaaaggg 1236001 cagagacatt ctgaaagtag agccgcagga ggaagcgcct gccaacggca tttctacttg 1236061 tgtgaaaggc aagttcggct gggatttcgt taacagcgaa gaacgcctga caaagccgct 1236121 gatccgtgaa ggcgatcatt tccgtgaagc agagtgggag gaggcgttat tgctgatcgc 1236181 cagcaagttc actgaattaa aagaggcgtt tggcccggat tctctcgctt ttattacatc 1236241 ttctaaatgt acaaatgaag aatcctatct tatgcaaaag ctggccagag gggtcattgg 1236301 cacaaataat gtggacaact gctctcgcta ttgccaatct cctgcgactg ccggcctgtt 1236361 ccggacagtc ggctatggcg gtgattcagg atcaattaca gatatcgcgc aagcggacct 1236421 tgttttgatt atcggttcga acacgtctga gtcgcatcca gtcttatcca ctcggattaa 1236481 acgggctcat aagctgagag ggcagaaagt gatcgtcgcg gatatcagaa agcacgaaat 1236541 ggcagagcgc tcagatttat ttgtccagcc gcgtgccgga tcggatatcg tctggctgaa 1236601 tgcgatcgcc aaatatttaa tagaaaacgg caaggccgat gaacgatttt tgagagaaag 1236661 agtgaacgga cgggatgaat atgtaaaaag cctcgcgccg tacacacttg aatatgctga 1236721 ggagaaaacc gggattgatc aagaaaccct tatccaaatg gcagagatga tcgggcaagc 1236781 tgacagtgtg tgcgcattgt gggcgatggg cgtgacacag catattggag gaagcgacac 1236841 gagcacggcg atctctaatc tgctgcttgt gacaggaaac tacggaaaac cgggagcagg 1236901 ttcttaccca ttgcgcggcc ataacaacgt gcagggagca agtgactttg ggagtatgcc 1236961 tgacagacta ccgggctatg aaaaagtgac ggacgaacaa gtccgccaaa aatacgagcg 1237021 tgtgtggggt gtgccgctgc cgaaggagcc gggtatgacc aaccacgaaa tgattgaaaa 1237081 aatccattcc ggacagttga aagcgatgta tgtaaaaggt gaagaaatgg gccttgtcga 1237141 ctccaatatc aatcatgtac acgctgcata tgaaaagctt gatttctttg tggtgcagga 1237201 cattttcctt tcacgtacag cggagtttgc tgatgtggtt cttcctgcga gcccgagcct 1237261 tgaaaaagaa ggaacgttta caaacacaga acgccggatt cagcgtttgt atcaggtatt 1237321 tgaaccgctg ggtgaatcaa agccggattg gcagattatt atggaggttg ccaataagct 1237381 tggcgccggc tggctctatg agcatcctgc agacattatg gaggaagcag ccaagctgtc 1237441 gccgatttat gccggtgtca cctatgaacg tcttgagggc tataattccc tgcaatggcc 1237501 tgtaaacgct gatggaaagg attcgccttt actctttaca gagcgcttcc ctttcccaga 1237561 cggcaaggcc attctctacc ctgtccagtg gacagagcct aaggaattcg gtgaggaata 1237621 tgatatccat gtcaacaatg ggcggctctt ggagcacttc cacgaaggga acctgactta 1237681 caaatcaaaa gggatttcgg agaaaacacc ggaagtgttc ttagaaattt ctcctgagct 1237741 tgcggcagaa cgagggattc aggacggaac cctcgtcaga ctcacatcgc ctttcggaaa 1237801 tgtcaaagtg aagtgcctga ttactgatcg agtcaaaggg aaggaagtat atctgccaat 1237861 gaacgattca ggggaagcgg cgatcaacct gttaacaggc agccatgccg ataaggatac 1237921 cgatacgcct gcttacaaag aaacatcggc caagatggaa attttgaagc acgacggaat 1237981 cagcccgctg cctaagatca accaccgcaa cggcaatccg cagccgcaaa tcggtgtgca 1238041 ggttcataag aaatgggcgc ggaaggatta tattttccct ggtgacgctg tgaaaagggg 1238101 gatgggccat aatggctaaa gcgattaaac gaatccaaaa aatcgaggta acagaagagg 1238161 atcagcgaaa gcgtgatttg cgggaaattg aagatgctct aattgaccac aaagaagcga 1238221 ttctcgaaac attgcatatg ctgggccata tgaacgagcg cggggtcctg ccgttgctcc 1238281 gcggcctttt tggtcaaggg gataaagttc ttgatatcct ggtgaaaaag gcagatacag 1238341 aggaaacagc caatacgctg aaaaatctgc ttcttctgtt tggaacactc ggcatgctgg 1238401 acgtgaagca gctggagcct ctcattttga aagtgaatgc gggtgtggca agcgctgtag 1238461 agcagaaaaa cagtgaagaa aagacaggtt attttgatat tatccgctcg ctaaaagacc 1238521 cggaaatcaa caaatcaatt acactgctct tttccttttt aaaaggaatg ggacaagata 1238581 caaaggagct ggaacgcacg acgcagcctc cggaacacca aaaacatcat caggaacccc 1238641 gagagaaaag aggaatgaat aagcgagatt gacctcccac ccgagcggct tcagccagct 1238701 cgggtttttt gatgaaaagg tctaatggac tagtaaaaaa tattcaaata ctaggaagaa 1238761 gtaagattgt gatgaatgag atagaaataa tcgttacttt cttacctgtt aagaaaaggg 1238821 aaaatctgat tataatagaa atcgattact ttagatgggg gaacaatcat gaaaaaagtc 1238881 ttattactat tatttgtctt gacgatcggg ttagcgcttt ctgcgtgcag ccaatcgagc 1238941 gatgcgtcag agaaggaaaa accgaaagag aaaaaatcgc aagaagagct tgaaaaggaa 1239001 cttgataagg aattgaaaaa aggcggtgag ccgaagacca aaaaagatga tcaaatacat 1239061 aaaataggag aaacatttaa agcaggacat acgaatttta cagtgaataa agttgataga 1239121 gtgcaaaaag gtgaatatat gaatgttggc ggagctgtaa atgaggagac aaaaacaata 1239181 aaagatgatg aggaacggct tattatagaa gttacgatgg aaaatatagg ggaagattca 1239241 ataagctaca attttatcgg gtttgattta agagataaga atgatcaatc agtgcggcct 1239301 gttttttcta tagaagagaa gggcagaatc cttatgggag gaacactagt atcggggaaa 1239361 aaggttacag gtgtactcag ttatgtcatc cctaaaggag aacagaaaca ttacacactg 1239421 gtatataatc cgtttttagc tgatacaaat agcagtaata cagaagagag agtaaaggac 1239481 gatattgatt acttggtgaa gttagattag atgctaattt acagttgcac gtttttcatc 1239541 tgtggaaaac gtgcattttt tatagcgaaa cttgacttga aaggatgagt gataaaagtg 1239601 caaaccaaat ggctggaacg ggcacagcgg attcgggcga tcgcccaagc ggggcttgct 1239661 ttttccaagg atgtgtacga cagggagagg tacgaagagc taatgaagct tagcgcggaa 1239721 atgatggcgg attactcgga gaaggacatt gaagttatca ctgatttatg gcaaggcgag 1239781 aagggctatc caacaccgaa agcggatgtt cgcggcgctg tattcagaga gaatcagatt 1239841 ttgcttgtcc gggagaagca tgatgagctg tggtcgctgc cgggcggatt ttgcgagatt 1239901 ggtttatcgc cggctgaaaa cgttgtcaag gaaatcaaag aagagtcggg gtacgataca 1239961 gagccgtctc gattgctggc cgtgctagac agccataaac actctcatcc ccctcagcct 1240021 tatcactatt ataaaatctt catcgcatgc agcatgacgg acgggcaggg ggaaacaggg 1240081 atcgagacga atcatgccgc tttttttccg gaagacagac tcccgccgct ttctcctaaa 1240141 cgaaacacac cctcacagct tagcatgctg tttgactttt tgcgccatcc ggacaagaaa 1240201 acgatatttg actaaaaaag aaagagcctg tgggctcttt cttttttata atgtaatgtg 1240261 tttttcgttg gcgagtttca gaagggtcaa aatagaatcg gcttgtttat ggccgagttt 1240321 ttgctttaat ttgttttctt caactaatcg gctgccataa attttgacgg aggctttgtc 1240381 gacgacagta tgccagtttt cctgtttttt tccctcaaca agcggttttt catgtctctc 1240441 agaaaaagag aacacaaaga gtacgaatgc aagtgaaagt aggattccga caacttgttt 1240501 tttgtaatca gtctgtgctg ccacgttgtt ctctccttca ccttttacct tctatttaat 1240561 catagaacca aattatttta cataatggga aagtcatttt tggagttagt gcatttggtt 1240621 gaaaacagag acgttttttg agcggagcgg tgcaattgaa tccatattgg atttgcgtgc 1240681 ttatgcctaa ggtcacgttg tgagccaaaa cagcagtgca gaatagaaaa aaattgaaag 1240741 attatggtaa gatgaacgaa attcgagggg gaatatatga tgcctgcatc gaacatcgtg 1240801 atcgcctgcc tgctgttatc aatttaatta tttgtggtag tccctctctt tttcgaaagc 1240861 gggaggtgaa gtggaacatt aattgctgaa ttctttcaag gggagtgacc gtacatgaat 1240921 gtgttaaacc gccggcaagc cttgcagcga gcgctgctca atgggaaaaa caaacaggat 1240981 gcgtatcatc cgtttccatg gtatgaatcg atgagaaagg atgcgcctgt ttcctttgat 1241041 gaagaaaacc aagtgtggag cgtttttctt tatgatgatg tcaaaaaagt tgttggggat 1241101 aaagagttgt tttccagttg catgccgcag cagacaagct ctattggaaa ttccatcatt 1241161 aacatggacc cgccgaagca tacaaaaatc cgttcagtcg tgaacaaagc ctttactccg 1241221 cgcgtgatga agcaatggga accgagaatt caagaaatca cagatgaact gattcaaaaa 1241281 tttcaggggc gcagtgagtt tgaccttgtt cacgattttt catacccgct tccggttatt 1241341 gtgatatctg agctgctggg agtgccttca gcgcatatgg aacagtttaa agcatggtct 1241401 gatcttctgg tcagtacacc gaaggataaa agtgaagaag ctgaaaaagc ctttttggaa 1241461 gaacgagata agtgtgagga agaactggcc gcgttttttg ccggcatcat agaagaaaag 1241521 cgaaacaaac cggaacagga tattatttct attttagtgg aagcggaaga aacaggcgag 1241581 aagctgtccg gtgaagagct gattccgttt tgcacgctgc tgctggtggc cggaaatgaa 1241641 accactacaa acctgatttc aaatgcgatg tacagcatat tagaaacgcc aggcgtttac 1241701 gaggaactgc gcagccatcc tgaactgatg cctcaggcag tggaggaagc cttgcgtttc 1241761 agagcgccgg ccccggtttt gaggcgcatt gccaagcggg atacggagat cggggggcac 1241821 ctgattaaag aaggtgatat ggttttggcg tttgtggcat cggcaaatcg tgatgaagca 1241881 aagtttgaca gaccgcacat gtttgatatc cgccgccatc ccaatccgca tattgcgttt 1241941 ggccacggca tccatttttg ccttggggcc ccgcttgccc gtcttgaagc aaatatcgcg 1242001 ttaacgtctt tgatttctgc ttttcctcat atggagtgcg tcagtatcac tccgattgaa 1242061 aacagtgtga tatacggatt aaagagcttc cgtgtgaaaa tgtaatagat aaggagactg 1242121 gagattcatg aaaaagtacc atatttcgat gatcaatatc ccggcgtacg gacatgtcaa 1242181 tcctacgctt gctttagtag agaagctttg tgagaaaggg caccgtgtca cgtacgcgac 1242241 gactgaggag tttgcgcccg ctgttcagca agccggtgga gaagcattga tctatcatac 1242301 atccttgaat attgatccta agcaaatcag ggagatgatg gaaaagaatg acgcgcccct 1242361 cagccttttg aaagaatcac tcagcattct gccgcagctt gaggagttat ataaggatga 1242421 tcagcctgat ctgatcatct atgactttgt tgcgctggct ggtaaattgt ttgctgaaaa 1242481 gcttaatgtt ccggtcatta agctctgttc gtcatatgcc caaaatgaat cctttcagtt 1242541 aggaaatgaa gacatgctga aaaaaataag agaagcagag gctgaattta aagcctactt 1242601 ggagcaagag aagttgccgg ctgtttcatt tgaacagtta gctgtgccgg aagcattaaa 1242661 tattgtcttt atgccgaagt cttttcagat tcagcatgag acgttcgatg accgtttctg 1242721 ttttgtcggc ccctctctcg gagaacggaa ggaaaaagaa agcctgttga ttgacaagga 1242781 tgatcgcccg cttatgctga tttctttggg tacggcgttt aacgcatggc cggaatttta 1242841 caagatgtgc atcaaggcat ttcgggattc ttcatggcaa gtgatcatgt cggttgggaa 1242901 aacgattgat ccagaaagct tggaggatat tcctgctaac tttaccattc gccaaagtgt 1242961 gccgcagctt gaggtgttag agaaagctga tttgttcatc tctcatggcg ggatgaacag 1243021 tacgatggaa gcgatgaacg caggtgtgcc gcttgtcgtc attccgcaaa tgtatgagca 1243081 ggagctcact gcaaatcggg ttgatgaatt aggccttggc gtttatttgc cgaaagagga 1243141 agtgactgtt tccagcctgc aggaagcggt tcaggctgta tccagtgatc aagagctgct 1243201 cagccgcgtc aagaatatgc aaaaggatgt aaaagaagct ggcggagcgg agcgtgcggc 1243261 agctgagatt gaagcgttta tgaaaaaatc cgctgtcccg cagtaaaaac ataaaaaccg 1243321 aaatcaattt gatttcggtt ttctgtttaa atattttttt tcatcccgca tctccggcat 1243381 tctctaagaa attttccgcc ttttacagag cttttgaaca gtgtgtaatc acagttgtcg 1243441 cagcgcccgc tgcgggcatc cggatattca ttgaattcgt aaacaatcga tgtatcgtag 1243501 ccttttgttt catattcttc ttttttggtt tccatgtcga tcctccgtta caagacgtgt 1243561 ctgctgttta tcttacagca agcttccggc gtattcaatg gattttagga ggttgggttt 1243621 atcttgattt ctcccttggt ttgcgccaaa atagctttat taagcttata tacataaaaa 1243681 gcctatgcaa agaggagagg aaacgggtat gggaaaaggg ttacttggaa aacgcgtggc 1243741 aatcggtggc tcacgaaaaa cggaagaaat tagtacaatc attgaaaaac agggcggaat 1243801 acctgtcatc cggcctctcc aaggtacagt ttacttagca gagaagcagg tggagccgga 1243861 tttgcggacg tttgcggaag aaaaagctga ctgggtcatt ttcacgacag gcatcgggtt 1243921 ggagactctt gtcgatatgg cagagaaaat tggactgaaa gatgagtttc tgcaggccat 1243981 tcgccaagcg aaagcggcat gccggggata caaaacgctg tctgcgctga aaaagcttgg 1244041 aatcacaccg gaagcttcgg atgaagacgg gacaacaaga ggcttaatcc gttccttgga 1244101 gcctcacgac ttttcaggaa aaacagtcat ggtgcagctt catggcgaaa aagcgccggc 1244161 tctcatggca tttcttgaag aaaaaggcgc gtctgtcctg ccgattctgc cttatcagca 1244221 catcccgccg gaggaggaaa cggtggagcg gttatgccga gagctgatga acgatgaggt 1244281 cgatgccgtt tgttttacaa cggccattca ggttcgttcc ctgtttgatt ttgccaaggg 1244341 gcgaggttat atcaatgaag tgaagaaggt attcgaagaa cgcgccatcg cagctgctgt 1244401 cggaaaagtg actgctgaag cactgcggga agagggcatt acgagactgc ttgcgccaga 1244461 gattgagcgg atgggtgcga tgattgttga gctggccaag tattatgaag aaaaggaata 1244521 acaagtacaa aaagccgctt ttccctcgga aagcggcttt tgtctgtcat tcattttgct 1244581 tcagctgctg atgaacggtg aataatgatg ggtatgtcag cacgcttaag attacacaag 1244641 tcagcgcggc tgaggccatc gttgtaaaca cgattaagag ttgaaagcgt actgcctgaa 1244701 tcgggtccgc gccggctaga atctggccag tcatcatgcc gggaagctgg acaagaccca 1244761 gtgttttctg gctttcgagc gtcgggatca tactcatttt catcgctgag gtaagaatgc 1244821 gctgtatgga ttgcttcggt gtgccgccaa gtgacaatat taattgaatt tcttctttgc 1244881 gaacgccgac ttctgagtta agccggttta gaaacaaact tgagagcacc atcgaatttc 1244941 cgatgaccat cccgctgatc ggaatgacat atcgtgccgt aagcggaatg atatgaagag 1245001 acagcagaat tccctgcgtc acaatttcta cgattgctaa cgcggcaaac accctccaaa 1245061 acgaaccgat agtatttttc tttcgcttga tgacattttg cgccgccacc gcgagcatta 1245121 acagcaccat cagcaggata aaaacagggt ggtctccgcg aaaaatcagc gacaaaacat 1245181 aaccgatgat aagcagctgc accgcggccc ggatggtggc gatgatcatg tctttttcta 1245241 caccggcttt aaaggatttt gataaaaaca aggcgatcaa aacaaagatc atcgttaaag 1245301 agagagaaag gtaatccatt accgagtgcc tcccttcaaa aattctttcg ctgcttcatg 1245361 ctgcggagcg gagaaaaatg tgtcggtttc agcgatttca agcagccggc catctgccat 1245421 aaaccaaatg gtatcggcta ttcgttttgc ctgctccata ttatgagtga cccacatgac 1245481 tgtccatttt ttctcttgat gctgacgttt gatcagttct tcaatctcaa gagcagagac 1245541 cgggtccaag gccgatgtga tttcgtccaa caatagaatg gaggaaggat ttgagagcgt 1245601 tctggccagt gacagtcttt gccgctgccc gcccgataag tctctggcgc ttctgtctaa 1245661 caactctggc ggcagccctg caagcgaagc cagcttttca ggagagtaca gctgggattg 1245721 atgcagcctt tgtacaagac ttaaattgtc acgcactgtc ccgtcgagca cgggagccga 1245781 ttgaaacgcg agggctgccg ttcgcctcag ctcattgaca ttccattctc tgacttcctt 1245841 tccgtatatg ttgacttcgc cgctgtcagg cgttctcatt aaattacaca tagaaaggag 1245901 ggtgcttttg cctgagccgg aagggcctaa aacggctacg attgcaccct gttgaatgtc 1245961 tccggtgaca tcctgcagca catcataggt ttgtccatct tgtttatagc tttttctgac 1246021 tgatctgaag gagatggctg gtatgttttg tgtttgatcg tttgcttcca ttacaataat 1246081 cacctttcaa tataagtagg ctgacattat atttaactat aacgtgaaac agattccttt 1246141 tggtagcaca aataaaggag aacaggcttt cacccattct cctgcagatg ctacgcagtc 1246201 agatttgact gtgctttctt tttcggtttt ctcggctgtg aagcgaaggt atgtaacatc 1246261 atccccgcta ttataatgaa caaaccggca aatgataata gagatgggaa aacgcctgac 1246321 agcagaacaa tttcaccaag cagcgcgaaa atcacttcac cggattgagt ggcttcaaca 1246381 gctgcgagtt tttgcggatt gtctcttacc atatcagtgg cccagaaaaa taaaaccgtc 1246441 gcaatgatgc ctgagctgac ggcaacgata aaggattgaa cggtttgact tgctgttgga 1246501 aggccatctg accaccagcc gtaagctgct aatataagcc agaatggaag gcttgccaat 1246561 gtcattccaa gcacgcgctg aaatgtatca agccggcctc cgtattcttc gagcattctt 1246621 cggtttccta acggataggc aaaagccgca atgacaaccg gcagcacact gaaaagcagc 1246681 atcctcccag aaagcgattc tgcatgctga agctgaatca gagccgctcc aatcaggatg 1246741 atcacagaag tgccaagtga aaccagggga atcttttggc gaatgagctg cggaccgccc 1246801 ggcatatctt gtttgacata aaacaaagga gataagagca ccccggctac aattgtaatt 1246861 tgccaggttc cagctatgag ccaccccgga ccgtatgcag ccgcaaatgt aatcggtgcg 1246921 taaaaaagca cgaaaccgac gaagctccat ttgatccaat aaaacggctt tttcctcatt 1246981 tctagtaaga gaggcgtgaa tgtccctctc atgatgacaa tcaaacataa aaatggcacc 1247041 ataaaaataa agcgcagcga agagctccaa agccagctgc ctcctgataa ctccatcgct 1247101 ctgtttaata taaaggtaac ggcgaaaaag agtgaagcca atattccgat aacgatagct 1247161 ttcatgatat ccctcattct ggcattattt ttttatacta tactattcgg tatcatgcag 1247221 atcaatggaa tcatgagaaa aacatcatgt ttggcgaacc gctatatgtg gaagacaaaa 1247281 aagggaggtg aaattgatgg aaagagagac acagacatac ttctttccgg atgacggcag 1247341 gattccgaat caccctgatt ttccgctcgt ggtgtatcaa aacgcgctta aggacaccgg 1247401 actggcagag cggatcgtca cccggcatgg ctggtcaaac agctggtcag ggagtgtttt 1247461 tccataccat cattatcaca gcaatacgca tgaagtcctg attgccctta ggagagaggc 1247521 tgtgattcag tttgggggag aaaaaggggc tgccatccct ttcaaatcag gcgacgcagt 1247581 cgtgattcca gccggagtcg gacataaaaa gctcagctca agccccgatt ttactgtcct 1247641 tggcgcctat cccggtggcg ttcagtacga tatgaagacg gggaagccga atgagcggga 1247701 ggaagcggtc aaacagatta agcaggcggc gttgccggcg aatgatccga tcacaggaaa 1247761 aagagagcct ctattggaaa tatgggtaaa gtgaagggga gaaattgctg gattgtcaat 1247821 aactagtgcc gcagaaacga tatgacatga gctccatata aattaatttc ataatcgaag 1247881 caattcacgt tcaaattttg ttcaaaaagt gttatcatat agaaggtaat cgaattggag 1247941 ttttttgtgt ttgctatttt cagagagagt aaaggatttt gacttattca attgtttatt 1248001 tttagataaa aataatactg aatatggcaa gatgaaaaac tgggtagtaa acatttattt 1248061 ttgtaaatga ttgtgcatga attcacaatc cttattctta tgccttaaaa gcgtgagaca 1248121 gggagaggca ctaccctttc caaaaaaatc agcaaactgc ttatagtaaa ggagaattgg 1248181 atatgccaga aacaatcgat caaacaaatg cgtctgtcag ccaaagccag caagatctta 1248241 ttgatcagct attaaagcca gaagttcaag aatcattgac tgttttagtt gaccagcttc 1248301 cgaagctgac tgagttagtg aatattttaa cgaagtctta tgatttcgct cagtctgtag 1248361 cgactgacga agtgttaaag agcgacacag tcggtgcgat cactgaaatt ctcgagcctg 1248421 taaaagaaac agcgaaagaa gtagctgcga ctgcgatcga agcaaaagac cgcgcggaag 1248481 caagcaacga aacaattgga cttttcggcc ttcttcgcat gctgaaagat cctcaagctc 1248541 aaaagctgtt ccgttttgct aacagctacc ttgaagtcat gaacgaacgc gaaaaccaaa 1248601 aataatctca gattcaaatt gatataaagg acggaggata tacgatgtca aaacatattg 1248661 tcattctagg cgctggttat ggcggagttc tttctgctct aacagttcgc aaacattaca 1248721 caaaagaaca agcacgcgtg acagtggtaa acaaataccc aactcaccaa atcattacgg 1248781 aattacaccg ccttgctgca ggcaacgtgt ctgaaaaagc ggttgcaatg ccattagaaa 1248841 aacttttcaa aggcaaagac attgatctta aaattgcgga agtaagctct ttctctgttg 1248901 ataaaaaaga agttgcgctt gctgacggtt ctacattaac ttacgatgcg cttgttgtag 1248961 gtcttggttc tgtaacggct tacttcggca tcccaggtct tgaagaaaac agcatggtat 1249021 tgaaatctgc tgccgatgcg aacaaagtct tccaacatgt tgaagatcgt gtgcgcgagt 1249081 actctaaaac gaaaaacgaa gcagatgcaa caatccttat cggcggaggc ggcttaacag 1249141 gtgttgagct tgttggtgag cttgctgaca tcatgccgaa ccttgcgaaa aaatacggcg 1249201 tagaccataa agaaatcaaa ttgaaacttg ttgaagcagg tccgaagatc cttcctgttc 1249261 ttccggatga tcttatcgag cgtgcgactg caagccttga aaaacgcggc gttgagttct 1249321 taacaggtct tcctgttaca aatgtagaag gaaacgtaat cgatctgaaa gacggatcta 1249381 aagttgttgc caacacattt gtttggactg gcggcgtaca aggtaaccca ttagtcggtg 1249441 aatcaggcct agaagtgaac cgcggacgcg cgactgtaaa tgacttcctg caatctacat 1249501 ctcatgaaga tgtattcgtt gctggagaca gcgcagttta cttcggtcca gacggccgtc 1249561 catacccgcc aactgcacaa atcgcatggc aaatgggtga gctgatcggt tacaacctat 1249621 tcgcttacct agaaggcaaa acgcttgaaa cattcaagcc agtaaactct ggtacacttg 1249681 caagccttgg acgcaaagac gcggttgcca tcattggtgc taattctaca ccgcttaaag 1249741 gtcttcctgc ttccttgatg aaagaagcaa gtaatgtacg atatttgaca catattaaag 1249801 gacttttcag cctggcttac taatcctttt aatgaatctg gcattgccaa aagcattcct 1249861 ttccgagtgc tttctggcaa tgtctttttt tatgtttatg acagcgttaa catttcattt 1249921 tcaaaaaaga gattgatccc aaaggaatat aaaggtaaaa taaaaacaaa tcaaaatgtt 1249981 aacgttaaca ttttgaaata gaatgaaaga cggtgaggac atggaaccct tcatgggcaa 1250041 aaacttttta ttgaaaaatg aaaccgctgt cagcctctat cacaattatg cgaaagacat 1250101 gccaattatt gattaccact gccacttaag tccgaaagaa atctatgaaa ataagacatt 1250161 tcaaaacatc acggaagcct ggctgtatgg tgaccattat aaatggcgca tcatgagagc 1250221 caatggaatt gaggagacat acattaccgg agatgcgcct gatgaggaga aatttatggc 1250281 ttgggcgaaa accgtgccga tggcgattgg caacccgctc tacaactgga ctcacttaga 1250341 attgcagcgt ttttttggca tttacgagat tttaaacgag aagtccgggt cggctatatg 1250401 gaaacagaca aataaactgc tcaaagggga aggcttcggg gcaagggatt taatcgtgaa 1250461 atcaaatgta aaggtcgtgt gcaccacaga tgaccctgtt gattctcttg aataccattt 1250521 attgttaaaa gaagacaaag actttcctgt cagtgtgctg cctggatttc ggccggataa 1250581 aggacttgag atcaatcgtg aaggctttcc tgagtgggtg caggcgcttg aagatgccgc 1250641 tgccatatcg attacaacct atgatgagtt tttaaaggcg ttggaaaaac gagtgcgatt 1250701 cttccactca gccggcggca gagtttctga tcacgcgata gatacaatgg tatttgccga 1250761 aacaacaaaa gaagaagctg gacggatttt ttctgacaga ttacaaggaa cagaggtttc 1250821 ttgtgaagat gagaagaaat ttaagacata tacgcttcag tttctttgcg gtttgtatgc 1250881 ggagctcgat tgggcgatgc agtttcatat caacgcttta agaaacacga atacaaaaat 1250941 gatgaaaagg ctcggacctg atacagggta tgattcaatg aacgatgaag aaattgctaa 1251001 gcctttatac aagctgctga actcagttga gatgaagaac cagctgccga aaacgatttt 1251061 atattcactg aatccaaatg ataactatgt catcgccagc atgatcaaca gttttcagga 1251121 cggtattacc ccgggaaaaa tacaattcgg cacagcctgg tggtttaacg atactaaaga 1251181 cggaatgctc gaccaaatga aagcgttatc aaatgttggc cttttcagcc gttttatcgg 1251241 catgctcacc gattccagaa gctttctttc gtatacgcgc cacgaatatt tcaggcggat 1251301 cgtctgcaat ttgattggag aatgggtgga aaacggcgaa gtgccgcgcg atatggagct 1251361 tctgggaagc atcgttcagg ggatttgcta tgacaatgcg aaacactact ttcaatttca 1251421 agaagagaaa gcaaacgtgt aacaaagtgt ccgctcagta tcgctgagcg gatcactatc 1251481 cgaaaattct taagacacag aggtggaaca tgcgaactga actggcaaat aaggttgtgt 1251541 cggtcgaaac ggaaaaaagg ctttcattga aagagaaaat gtcctatggc tttggtgatt 1251601 ttggcaacgg ttttatgttt gatctcggcc agatttattt attgaagtat ttcactgatg 1251661 tagcgggaat ccccgctgcg atggccggcg gcattttttt agtcagtaag ctgtttgcag 1251721 cgataacaga tccaattgtc ggctcatcaa tcgattatcg caaaaacatc ggcaaacggg 1251781 ggaaattcag gccttatcta ttaatcggca gcatcgtgct tgcggtgctt actgttctta 1251841 tttttctgtc tcccaatgta tcaacgaccg gaaaactgat atatgcatat gcatcctata 1251901 tgatttgggg catcggctat tcgtttgtga atattccgta cggctcatta ggggcagcga 1251961 tgactcaaaa ttctgaggac cggacctcca tttcgacgtt ccgccaaatc ggatcacttg 1252021 gcgccttgtt tatcacaagt gtggccgtga tgccgctgct cgtcaagttt gataatccga 1252081 aggtcggcta cccggtggtc atgggcttgt tcgccgcgct cggtgtgttt tggttttata 1252141 tttgctaccg caactgcaaa gagcgcatta tcatatcgga agcacccaaa gaaaaattaa 1252201 cactctcatc tgtcgtcaaa acatttatta caaataaacc gctgttaacc cttgtcctga 1252261 tgacgatttt ttcaatttcc gcatacaaca ttaaatccgc catgctcgtc tatttcgcac 1252321 aatataactt gggcaatgtt gaattaatgg cttatatgaa cttcatcatt attggttctt 1252381 cctttttggg cgtcgtattc cttccaaagc tcgtcaagat gtttggaaag aaacgaacgg 1252441 caatgatcgg ctttggcatc agtgtggccg cggatctgat caactttatg cttccatcta 1252501 acgtttatgt gtttacaatt ctcgccagta tcgcctttat cggaatcagt atcccaaatg 1252561 gcatcacgtg ggctcttgtc tccgatatta tcgactatgg cgaatggaaa tccggtgaac 1252621 ggaaggaagc aacgacatat tcacttttca atttctcaag aaagcttgct caatctttgt 1252681 ctggctttct ctcggggatc ggtttgggga ttatcggcta tgtgccgaat gcagtccaga 1252741 cagcacaggc gctgattggc atcaaagcgc tgcttcttct gtatccggcc attgctttgg 1252801 cattagcgat gttcattatc ggctttcttt ataaactcac agaccagcag catgctcaga 1252861 tcgttcagga tcttcatcaa aagagctgac aatataatat aaagaatatt taaaataatt 1252921 tgtaaataaa atgtgtttgt aggggtttcg cttggagagt gcccaaaaaa ctgaaaagga 1252981 aggaggcact tgcttgaaaa cgataacaat tgcagctgaa gaagcaaagg aactcgtttg 1253041 gcaaaagctg gacggtgccg gtttgaatga acgagatgct gaaaaagtgg cagatgttct 1253101 cgtgcacgct gatttgcgca atgtacattc gcatggcgtg ctgcacacag aacactatgt 1253161 gaacaggctt ttagcgggag ggatcaatcc tggggcacag cctgttttta aagagacggg 1253221 gcctgtgacc ggggtgcttg acggagacga tggtttcggt catgtgaatt gcgacatggc 1253281 gatggaccat gcaattgaca tggcgaagaa aaaaggagtc ggcatggtca cggccgtaaa 1253341 cagcagccat tgcggagcgc taagctattt tgtgcaaaaa gcggctgacg aaaagctgat 1253401 cggaatggca atgacgcata cagacagtat cgttgtccca tttgggggga ggactcctat 1253461 tttagggaca aatccgattg cttacggagt tccggctaag cataaaaaac cgtttatcct 1253521 agatatggcg acatccaaag tggcttttgg gaagattctg caggcccgtg aagagggcaa 1253581 agaaattcct gaaggatggg gagtcgatga aaacggagaa gcagtaactg atcctgacaa 1253641 ggtcgtctca ctttcaacat tcgggggccc gaaaggctat ggactatcga ttgtagtgga 1253701 tgtgttttcc ggattgctgg cgggcgcggc ttttggccct catattgcca aaatgtacaa 1253761 cggccttgat caaaaaagaa agctggggca ttacgtttgc gcgatcaatc catccttttt 1253821 tactgactgg gatacgtttt tagagcagat ggatgccatg attgatgaac tgcagcaatc 1253881 accgccggct gttggattcg aaagagtgta tgtgcccggc gagatcgagc agctgcatga 1253941 agaaagaaat aagaaaaacg gaatttctat cgcccggagc gtgtatgaat tcttaaaaag 1254001 caggtgagta aaatgaaagc ggttcaagtg cgaaaagcgt atgatctggt gacagcggag 1254061 gtgaagaagc cagttctttc aaaggatgat gaagtgctcg tgaaagtcaa gcgagtcggc 1254121 atttgcggtt cagacatgca catttatcat ggaacgaatc cgctcgctac cctcccgaga 1254181 gtcatcggac acgaggtaac gggacaagtg gaggcagttg gtgcgaatgt acagagccta 1254241 aaacccggtg atcatgtggt gattgagccg atttcttatt gcggatcgtg ctatgcctgc 1254301 cgcaaagggc ggccgaatgt ttgcgccaag ctttctgtat ttggcgtaca tgaggacgga 1254361 ggcatgcggg aatatattgt gcttccggaa agacagcttc acgcggtctc aaaggacttg 1254421 ccttgggagg aagcagtcat ggccgagcct tatacgatag gcgcccaggc agtgtggaga 1254481 ggccaggtgg aaaaaggtga taccgtcctg atccagggag cggggcccat cgggatctgt 1254541 gtgttaaaaa tggcaaaact ggcgggcgct gctgtcatga tgactgactt gaacaacgag 1254601 cggctggcat ttgcgaaaga aaacggcgcc gatgctgttg taaatgtcca agcagaacat 1254661 gttgccgagc gggtccttga atggactggg aatgaaggag caaacgtggt cattgatgct 1254721 gtttgcctgc cggagacttt tgcactttca attgaggctg tgtcaccggc gggacatgtg 1254781 gttgtgcttg gatttgatga aagagcggct cagatttctc agctgccaat tacaaaaaaa 1254841 gaagtcacga taaccggatc ccgattgcag accaatcagt ttccaaaagt ggtagagctt 1254901 ttgaatggag gccggttaat gcataacggg ctggtgaccc atacattttc agttgatgac 1254961 gttcatcatg catttcagtt tattaaggag catccagatc aggtgcggaa agccgtcatc 1255021 acgtttgatt aaatgactga atccggaggt gcgagcatga atatgacatt ccgatggtat 1255081 ggacgaggca acgatacagt cacacttgaa tacgtgaagc aaattcccgg tgtcaaaggc 1255141 atcgtttggg ctctccatca aaagcccgtc ggcgacgtgt gggaaaaaga agaaatcaga 1255201 gccgaaactg aatatattca atcctatggt tttcatgctg aagttgtaga aagcgtgaat 1255261 gttcacgaag cgattaaact tgggaacgaa gaacgcggcc ggtatattga aaactacaag 1255321 caaacgatcc gcaaccttgc cggatttggc gtgaaagtga tctgctataa ttttatgccg 1255381 gtttttgatt ggacacgcac ggacatgttc cggccgctag aagatggatc gaccgctctg 1255441 ttttttgaaa aggccaaggt ggaaagcctt gatcctcaag agctgattcg gacggtggag 1255501 gaagcatccg acatgacact gccggggtgg gagcccgaaa aattggctcg gatcaaagag 1255561 ctttttgctg cctacagaac ggtcgatgaa gaaaagctat gggacaattt atcattcttt 1255621 ttgcaggaaa ttcttcctgt tgctgaggcc tatggtgttc aaatggccat tcatccggat 1255681 gacccgccgt ggccgatttt cggactgccg cgcattatca caggagaggc aagctataag 1255741 aaactgcggg cgatatcaga ttcaccgtct aattgtatca ccctttgtac aggttcaatg 1255801 ggagccaatc ccgctaacga catggtggag atcgctaaaa cgtatgccgg catcgctcca 1255861 ttttcacata ttcgcaatgt gaaaatttat gagaatggcg attttattga aacatctcat 1255921 ttaacaaagg atggttcgat caacattcaa ggcgtgatgg aagaactgca taagcaggat 1255981 tacgaaggat atgtcagacc ggatcatggg cgccatcttt ggggcgagca atgccgcccg 1256041 ggatatggct tatacgatcg ggcacttggc atcatgtatt tgaacgggct gtgggacgct 1256101 tatgaagcaa tggcaaaaaa agaggtgggc atatgatccc gctgcatgag aacctggctg 1256161 gtaaaacggc tgtcatcact ggcggcagcg gcgtgctttg ctctgcgatg gcccgggagc 1256221 tagcccgtca tggcatgaag gtggcgattt tgaatcggac ggctgaaaaa ggccaagcgg 1256281 tcgtgaagga gataacggcg gctggcggca cagcgtgcgc tgttgctgcg gatgtgctgg 1256341 acaggatgtc actggagcgg gcaaaggaag acatccttgg ccaatttggc gctgttgatc 1256401 tgttaattaa cggggctggc ggcaatcatc ctgacgcgat aaccgatgtg gagacatatg 1256461 aagaagcggg agaaggccaa tccttttttg atatggatga gaggggcttt ctaactgtat 1256521 tctccaccaa cttcaccggt gcgtttctgg cctcgcaagt gtttggtaaa gaactgctga 1256581 aggcggattc acccgcgatc atcaaccttt cttccatgag tgcttattca cctatgacga 1256641 aggttccggc atacagtgct gcgaaagcat ccatcaataa ttttacgatg tggatggctg 1256701 ttcattttgc cgaaaccggg ctgcgggtca atgcgattgc cccaggcttc tttctgacaa 1256761 aacaaaatca tgatctgctg atcaaccaag acggaacgtt caccagccga tctcacaaaa 1256821 ttattgcggg aacaccgatg aagcgcttcg gaaaaccgga ggatttgctc ggtacgctcc 1256881 tttggctggc ggatgaatcc tattccggtt ttgtcactgg gatcaccgtt cctgtcgatg 1256941 gaggatttat ggcttattca ggtgtgtaac gaaagcggtg caacagaaac tgaaccaaca 1257001 taggggtgag gttgagatgt tttcaaaaga taagcttccc gttatccttt ttttgttcct 1257061 ggcaggggtg attaattacc tggatcgctc ggcgctttcc attgcagctc cttttattca 1257121 ggatgatctc acattgtctg ccacacaaat gggcttgatt ttcagcagtt tttcgatagg 1257181 ttatgccatt tttaattttc ttgggggcgt ggcatccgac cgctatgggg caaagctgac 1257241 cttgtttgtc gcgatggttg tttggtcgct gtttagcgga gcagtcgccc tcgcttttgg 1257301 ctttgtcagc ctgctgatta tacgcattct cttcggaatg ggagaaggcc cgctttcggc 1257361 gaccatcaac aagatggtga acaactggtt cccgccgacc cagcgggcgt ccgttatcgg 1257421 tgtaaccaac agcggcacgc ccctcggggg agccatttcc ggcccgatag tcggcatgat 1257481 cgcagtggcg ttcagctgga aggtatcctt cgttctcatt atgattattg gattgatatg 1257541 ggcagtgctc tggttcaagt ttgtcaaaga aaagccgcaa gagacgatca aggaagcacc 1257601 ggcaataaaa gcagaaacgt ctcccggaga aaaaattccg ctcacctttt acctgaagca 1257661 aaaaacagtc ctgttcacgg cgttcgcttt tttcgcttac aactacatcc tcttcttctt 1257721 tttgacatgg tttccgagct atcttgtcga cgagcgggga ttaagtgttg aatcgatgag 1257781 tgtcatcacg gtcataccgt ggattttagg atttatcggg ctggctgcgg ggggatttgt 1257841 ttctgactat gtgtacaaaa aaacggcccg aaaaggtgtg ctgttctcgc gcaaggttgt 1257901 gcttgtcacg tgtttgtttt catcagctgt cctgattggt tttgccgggc ttgtggcaac 1257961 gactgcgggg gctgtcactc ttgtcgctct gtcagtgttc tttctttatt tgaccggtgc 1258021 tatctattgg gctgtcattc aagatgtggt tgatcaaaac aatgtcggtt ctgttggcgg 1258081 cttcatgcat ttcctcgcca acacggcagg aattatcggc ccggctttaa ccggatttat 1258141 tgttgaccaa acaggcacgt tttctggagc atttttgctt gccggtgggc tggctgtctt 1258201 cgcttcactt gctgtgattc gttttgtccg tccaatcatt ggtaagccag cgggaacaga 1258261 agctgagaat cctgtgtctt attaatctgg aaatatagtg ggagaggcgg tatgtttgat 1258321 gatacaatat acagtaaata atcgcagccg gtatgataag gaagggaatt agatggtaac 1258381 cataaaagat atcgcaaaac tcgcaaacgt atcccacact actgtttcca gagcactcaa 1258441 caacagccct tacatcaaag aacatacgaa gaaaaaaata ttagagctag cagagcagct 1258501 caactataca ccaaatgtaa atgcgaaaag tctggcgatg caaaagtcgc atacgatcgg 1258561 gctattcttt acaagcatta caaacggaac ctcacacagc ttctttgcag acactatcaa 1258621 aggcgtcaat caagccataa gtgaggatta caatctgtat gtgcgcggca ttgatgatct 1258681 gaaaaactat gactccgtta caccgatgag atatgacggc atcattttaa tgagccaaag 1258741 tgacattgat aattctttta tttaccatat tcgcgaaaaa aacattccgc ttgtcgtgct 1258801 gaatcgtgat attgatgatc gtaccatcac gaatattttg tccaatgaca aggaaggctc 1258861 tcaagaagct gtagaatact tcattcagtc cggacatcaa gacatcgcca tcatcgaggg 1258921 gatcgaaggc tttaaatcct cccagcagcg aaaggaaggg tacttatccg cactgattca 1258981 acatcatatt ccgatcaagc atgaatacag tgtcaaagga cagtacgata tggaaagcgg 1259041 ctttcaagcg atggagcggc tgctggcact gccgaatcct ccaaccgctg ttttttgttc 1259101 gaatgatgac atggcaatcg gagcgatgaa tgcgatattc gcaaagggcc tgcgcgttcc 1259161 tgatgatatt tcggtgatcg ggtttgatga tattgggttt tcacagtaca tcacgccaag 1259221 gctttcaaca gtaaagcgcc cagtggagaa aataagcgtg ctcggtgcgc aaaaactctt 1259281 gtcgctgatc agcgagcccg aaacaaaagc agaaaaaatc ttggaaaaca cagaatttat 1259341 ggtgcgtgat tcagtcagac gattgacgac gtgatgtccc gtttttcagc gggcattctt 1259401 tatacagaaa aatgttaacg tgtgcataaa gtgagaggga ggcaataagg gtgcagaagc 1259461 tgaataaaaa tgtgtacgat cactatactc agtatccaga aaaaattctc caattcggag 1259521 aaggaaactt tcttcgggga tttatcgatt ggcagattga tcaattgaat caacacactg 1259581 attttaatgg gagcgtggca gttgtccagc caagaggctc agaaaaaatc aaacgattaa 1259641 atgagcaaga tggattatat acactttttt tacaaggaat gaaagacgga gaagcggtaa 1259701 acgagcatat gattatcaac tcaatcagcc ggggaattga cctgttttct gattatgaag 1259761 catacaaaga attggcatca agcgaaaggc ttcggtttat tatctccaac accactgagg 1259821 ctgggattgt atgtgatgaa aaagatcgtt tagaggatag gccgcaaaaa acattccctg 1259881 ggaaattaac tgcatttctt tactttcgct atcaggcttt taaaggagat cagacaaaag 1259941 ggtgtgtcct gatcccatgt gaactgatcg agaataacgg tgaaaagctg agggaaacgg 1260001 ttcttcatta tgcacatctg tggaagctgg aggaaggatt tacacagtgg attcatgagg 1260061 ccaatacatt ttgtaatagt ttagtagacc ggattgttcc gggttttccc gtcgacagca 1260121 ttgatgagat cacggcagat cttggctatc aggatgattt gatagttgtg ggagagcaat 1260181 attatttgtg ggttatcgag gggcctgatt ggattggaaa agaacttccc tttgcggctg 1260241 cagggctgca tacaaagatc gtcagcgacc tcaccccata ccggactaaa aaagtaagaa 1260301 ttttaaatgg cgctcataca gcaatgacgc cagtggcttt attatacggc ttgaagactg 1260361 ttagggatgc agtcgagcat ccggaagtgg ggcgatttat aagagagctg attgatgacg 1260421 aaattcttcc tgttttaaaa atggaaggtc tttctcagta tgctgacgat gtgctgaacc 1260481 gttttaaaaa cccgtatatt aagcattacc tggaaagcat tgcattgaac gccatttcca 1260541 aattcaaaac gagaaacctg ccgactctta aggaatatgc tgaacaaaag ggacagcttc 1260601 ctgaacgctt ggtgttttct ttcagcgctc ttctgtattt ttatcatgat aacgagacat 1260661 tgcaggatga tccggcagtt cttcaatttt tcaaagaggt ttggtgtcag gaggatggcg 1260721 acatgcttcg gattgcatca agagtgttag gcgaacagcg gctgtggggg gcagatctca 1260781 atgagatacc gaagctgact gatagagtcg ctgtttactt gaatcatatt catgagctgg 1260841 gcatgcagag ggctcttgaa caatactgca tacaaggggg agaggtacgt tgaagtcgtt 1260901 tataaagatt cataagcaag ataatgtcct tcttgctctg cgggatattc aaaagggaga 1260961 gaggctgcat gcttacggcg tgtcgattga agtaaaggat gatataaaaa gaggccataa 1261021 gattgcattg cagtctatca aagaaaacga cagcatcgtc aagtacgggt ttccaatcgg 1261081 tcatgcatca caagatatct cgatcggaga gcatattcat gtccataata cgaaaacaaa 1261141 cctgtctgat atccaattat acagctatac accgagattt gatgaaaatc cgtattctaa 1261201 tgagaaccgg acgtttaaag gttttagaag agaaaacgga gatgcgggtg tacggaatga 1261261 attgtggatt gtcccaactg tcggctgtgt caatggaata gcagaaaaaa tgctgcagcg 1261321 ttttgtcaga gaaacagggg atatcgctcc atttgataac gtactggtgt taaagcatca 1261381 atacggatgc tcgcagcttg gcgacgatca tgaaaatacg aagcagatcc tgctgaatgc 1261441 cattcgccat ccaaatgccg gcggcgtctt ggtgttaggg cttggctgtg aaaacaatga 1261501 gctggcaaga atgaaggaag cactgcaaga tgtgaacttg aagcgggtga agtttctgga 1261561 atcccagtcg gtgaccgacg aaatggaggc aggcgttgct ttgctgaagg aaattcatga 1261621 agcggccaaa ggagataaga gagaagacat tccgctgtct gaactgaaga tcgggctgaa 1261681 atgcggaggt tcggacggtt tttccggcat aaccgcaaac ccgctgcttg gacgtttttc 1261741 agattatctc attgcacagg gagggagtac tgtgctgacg gaagtaccgg aaatgttcgg 1261801 cgcagaaacc atcctgatgc agcgggctgc caatgaagaa gtgtttcata agatagtcga 1261861 tttaatcaat gatttcaaac aatactttat taaacatgat cagccggtgt acgaaaatcc 1261921 ttcaccgggc aacaaagcgg gcggcatttc tacacttgag gataaatcgc tgggctgtac 1261981 gcaaaaagcg gggatttctc ctgtcacgga tgtcttgaaa tacggtgaag tactcaagac 1262041 aaaagggctg actcttttga gcgcaccggg caatgatttg atcgcctcct ccgcattggc 1262101 ggctgccggc tgccaaattg tcctctttac aacgggaaga ggcacgccgt ttggcacctt 1262161 tgtcccgacg gtgaaagtag cgacaaacac cgagctgtat gaggcgaagc cgcattggat 1262221 tgattttaac gcaggccttt tagcagagga tgatgttcat gaggaatatg tgctgcgtga 1262281 gtttatccac tatatgattg aggtggcaag cggccagctt gtgaaccatg aaaaaaatga 1262341 tttcaaagaa ctcgccattt ttaaatcggg tgtgacgtta taataagaaa aggctatcct 1262401 tcaagcggat agccttcttc attaaatcaa ttttaaaccg ctgactaaaa taatggaagc 1262461 cataataaat tgcagtggac gcggggagaa tcgaggcgaa agatggctcc cgatcagtac 1262521 gccgggaatt gaaccgagga gcagattagc tgccagcatg taatccacgc ttccgaagct 1262581 tgcgttcaaa atgcctgctg ccgtaacaag aagaaaagca tgcgcgatat cggttccgac 1262641 aatctgtgac gctttcatgt taaataagta aatcatggcg attgcaaata atgagccgga 1262701 cccgattgat gttaatccga cgataaaccc aaacacaaca ccaataagaa ttgtcagcgc 1262761 cctcttattt tcaagcggca tcagctgcca gcggttgggg cgaagttttc tatccaaaaa 1262821 caaacgaacg atgattgaaa tggcaaccag cgttaacaca tatcctagag cgtgcttaat 1262881 aatttcttcc tgatgctggt gaaaggcggg gaacaaatgc aatatgccaa tggctagcga 1262941 agcactcgga ataccgccga tggctaagta ttttaccaat ttaaagttaa tcgttttctg 1263001 ccgccaatgg gaggcaacgc caaacagctt tgtgatcgag ttatatacaa gatccgtacc 1263061 gaccgcgatg gaaggattaa ttccaagcac aattaaaagg ggagttaata aggccgctcc 1263121 acccactccc gtcaatccga ctaaggctcc gacaaacaaa cccatcaata tgatgcttac 1263181 actcatgata aaggcctcct gaaaacccga ctagaattca cccgaatctt attcgcgttg 1263241 gtcaagtatt aattgtaagt gctccatcgg ctgctgaaaa acccgagctc tatccgctcc 1263301 ctgatggtat cattcaattg acaacacctt atacatcagg agaacacgtc tttcaggtgc 1263361 aacgagcact tgcggctctg tatttttacc ctgataaagg cgctgttaac aacggaattg 1263421 acggcgttta cggaccgaaa acagctgacg cagttgcccg ttttcagtct gttaacggtc 1263481 taactgctga cggtatctac gggcctgcga cgaaagagaa gatcgcagcg caattaagct 1263541 gatcaaagac cataaaaatc ccggagccgc tccgggattt attttttctt cttcaacttt 1263601 tttataattc cagcactgcg ctccctcacc cgaagcgagt acccggaaag cccaaacctt 1263661 ccgtaatcaa caaacttcac acgcctcacc aattttttca ctgtatcacc tgacattatc 1263721 ctctgtttgt atttattata tgtcaccctt taagaaaagg aataaggaca agagctgttt 1263781 tcccttgtcc ttttagtgtg atcatgcttt ttttcgttta tactcgtcaa tcagccgttc 1263841 gttttctttg aagattcttg ctgtatgcgg actgacttga tagcttgcga cactggtggt 1263901 tgaacgtttt ttcaggattt taaacggctt cgccgctctg ggctcgcatc tgttttgaaa 1263961 cgcacgttcc attatccttc accttcctcc tcaattggca gcaccaaatc atatatgctc 1264021 gttaatgacg taaatagcaa ataatcaaat tccgtgacaa tgctgtcaga cgtcagcttg 1264081 atgacatagt tctgtgtctc gatggtaaaa gggatgagaa ccacttttcc gtattggtcg 1264141 taataaacat cctttcgatc gagccgtgtt tgtacatctg ccggatcatc catatgctcg 1264201 gttaaccggt ctttatcagc ctgtgtcgaa tagtggcaaa gagaagccgt taagttcatt 1264261 ttatcagcat aggttttcag cagcttatca ataccttcag cataagcatc tatacttcca 1264321 taataaacat ggatcggttc gtttttcaat aggtattggt atgttttcag ccgattgaga 1264381 tacatgtgga gcatttcgtt gttttcttca agaatttctc ttgtgtctgt ttcaagctcg 1264441 ctgccggcca gttttttgac atatgcactt aagaagataa aagcatcaat caaagcaaaa 1264501 ctgactgcga caatgagata ccgttcccag tgggtaaata gggaagtggg ctcatatgtc 1264561 cagtatacca tagcgcccag aacaaacagc aaataccaag ttttccgaat ggcggacatt 1264621 ttttctttga ccttcgcttc gaaacgccac gtggcataca cgtataaccc cagtccggcc 1264681 acgatgcacc agaccatgat ctgaaagaat aaaaccatat tcgaatccct cacatctgaa 1264741 ataggttctg cttattgtat tcgagagatc cggatggttt tcctgttcca tcaaaaaaac 1264801 cgctcctttg acagaagcgg tgtgacatta aaatatcata tttaaaataa agtaggcgat 1264861 ggcaccaagt gtcgctgaaa tcggaagcgt gatgacccat gtaatgagca ttcgcttggc 1264921 cgtaccccag tttacgcctt ttacgcggtg ggacgcaccg acgccaagaa ttgatgaaga 1264981 aatgacgtgg gttgtactga ccggcaaatg aataaacgtg gcgccgaaaa taatggctgc 1265041 tccggttaag tcagcggaaa caccgtttac cggacggatt ttcatgatct ttccgccaac 1265101 ggttttgatg attttccagc cgccgattga tgttccgaga cccatggctg tcgcgcaggc 1265161 gaattgcacc caggtaggaa tatcattagc agaagtatgt aaattcgctg tgatgagagc 1265221 cattgtgata attcccattg ctttttgcgc atcgtttgtt ccgtgtgtat acgattgcag 1265281 ggcagctgtt acaatctgca ctctgcggaa ttgcttattc gttttcgcca agttgctgtc 1265341 tttgaaaatc agcttaacga tgctataaag aataaaacca aggacaaagg caataattgg 1265401 tgatagaatc agtgcttcaa tgattttaat gaagccctta tagtttaacg ctgcaaatcc 1265461 ggctgccgca atggctgcac cggcaatagc gccgatgatg gcatgggatg agctgcttgg 1265521 gataccgtag taccatgtga taaggttcca ggcaattgca gcgagtagcg cagccaaaat 1265581 gacaacagag ccattttcca gcgtataagg atctacgatg tctttcgtaa tggttttggc 1265641 aacacctgta aacgtcattg ctccgacaaa gttcatcaca gcagccaata taatggcatg 1265701 gcgcggtttt aacgcttttg ttgataccga agtcgcaatt gcgtttgccg tatcatgaaa 1265761 cccgttgatg aaatcaaacg ccagagcaca aatgactatt agtatcgtta atattaatag 1265821 aatatccatt tttacccctc gttacgcgtt tttcataatg atggtttcaa gattattggc 1265881 aacactttga caagagtcgg cgatttcttc aagcgtttcg tatatttcac gatattgaat 1265941 gactttgatt ggatctgttt catttccgaa aagattcttt aatgattttc tgtgcaagtt 1266001 gtcacaactg tgctcatact ctttaatttt gattgcgtga ggctgaatat cctttaagcg 1266061 attttctgcc agcagctcga tcgtaatcaa aatctctttc gcacattctc tgatatatcc 1266121 gctgaattta tcaatatgct cgtctgatga agtaattgag aaaatctcca tcatggcaga 1266181 gaaatgttcg attccgtcaa gcacatcatc caagctgttt gtcagctgaa ggatatcttc 1266241 gcgctcaata ggagtgatga acgctttgtt aagctcttta atcatgacat gaacatgatt 1266301 gtcacctttt gtttcatatt cctttaacgt atctgcaaat tctttaagag tcgtttggtt 1266361 agtgacctta aaattcacaa aatattctgc agtttcgtct atgttctttg caatttctgt 1266421 taaaaggagt gagaacttat ctttttttct tcttatcatt aaaaaccctc catagtttga 1266481 atgaacaatg cacacatcaa attattatat agccttttgt cgaaaaaaaa caggtaaagt 1266541 cgaaaaaaac gtatcttgac ttttttgata aatcgtgtct ccttattttg acctacttcg 1266601 ctttaaaaaa acgacccaag tttgcaaaaa ctttctgctt aacgtaaaaa gtatatcaaa 1266661 agttgtgttt ttcctgtcaa cttttatctt ctgtttcacc aaaaaacggt tccctaaaca 1266721 agggaaccgt tttatcagct tgcttttcgt tttttcatcc cgtaataaac aggcagtccg 1266781 gcaaggccga tgaggatgga taatccgcag ctcattgtat ctgtaatgag tgtgctgcct 1266841 aacacaaaga aggagcccgc gattgccaga attggcataa atggataaag cggaacactg 1266901 taggcgcgct tttctccctt tgctcgcttg cggagaataa acactgcaaa aaaggccatc 1266961 acataaaaaa tgtagatcat gaaaatggag atttctgaga gcttatcagg gttgctgatc 1267021 agcatcataa tcaaagccaa agcaatttga aaagaaatcg caatccatgg tgtgcggaac 1267081 gacgggtgta catgtgacag tttttcagca aatggaagct gtttgcgttc cgccattgca 1267141 aatgaaacac gcgggaaaga aagcaccttt ccatttaagc acccaaagat gctgacgata 1267201 atccctacac tgatcagctt tccgccaatt gaaccgaaca gcatggttgc agcggtgctt 1267261 gtcgcatttt caccaagcgt gacaatttcg ttcgctgaca ggatgtgaag caatgcaaaa 1267321 ttaatgaaaa tatagatcgc cgttacaatt aataatccgc ccgtcatagc gcgtggcagc 1267381 agcttttcgg gatttttcat ttctccgccg agagcggcaa ggagaatcca tccgtcataa 1267441 gcaaacaacg tagctaaaat agccgccccg aagttcatat cagaaatgct ttcgtttact 1267501 gctgtgaaga tgtgctgatc gcctttccaa aggccaaaga cgatgatgca ggcaatcgga 1267561 atcagttttc cgatcgttgt cagcgtttgg acaaaaccgc cgtattttgt accgataata 1267621 ttaatgacgc ataaaaagag aactgctata attccaatga cttttgatag tccagatccc 1267681 cagccgaaaa gattcgccat taaagatcca aaatataaac ccagcgcgcc aataatcgcc 1267741 gggccgtaaa tgataatctg cacccagccg cacaaaaatc cccaaaactc gccgtacact 1267801 tcttcaaggt acgtataaag cccgccggtt tttggaatct gcgttccgat ttccgcgatt 1267861 gtcaaaccgc ccgccagtgt taaaataccg cctaacagcc aggcgaaaag cgccattttt 1267921 gaatcacctg aataagcaag cacagcgccg ggcttcataa aaacaccaga accgataatg 1267981 gttccgatga caagagtaag ggcaaacaag aggcctatct cttttttcaa accgttgtct 1268041 tcagtatgca tgtccttaac ctcctatgat gttgaagctt catgttgaag aatctatttt 1268101 ttcatattgt aaaccctatt ttagaaaagt gaaataaaat aaattttctg attttcgaaa 1268161 tttgctttgt gtacagcaga taaaactgta gaaatacctg ttttaatggt ctataaacga 1268221 ataaaattca taatttttat ttacaaagtt cgtgttttat gtattaggat tttagccggt 1268281 acagagggga gatgagaatt cagaaaatga acgaaccttc ggtgaagctg atatgttgac 1268341 tttctcatgc gaataaaata ctttgttatt agaacaataa atatacaatt atgatatgat 1268401 atctcgaaat cgagataaaa taacctggag ggacagcata tgaaagttaa cggcattcac 1268461 cacgtatcgg cattaacggc cgacgcacaa aaaaacttgg atttctataa gaaagtatta 1268521 ggattaaagc tcgtcaaaaa atccgtcaat caggatgaac cgacaatgta ccatctgttc 1268581 tacggagatg aagtggcaaa cccgggaact gagctgacgt ttttcgagat tccccgcatt 1268641 gcaccgtttc atgcgggaac aaacagtatt tcttctattg gattgcgcgt tccaggcaca 1268701 gaagccctgc attactggaa agaacgtttt gaagagcagc aagtaacgca cagcggcatc 1268761 tccaaaagag ccggacgtga catattggca tttcaagatc atgaggggca gcgacttgtg 1268821 ctgactgctg atgaggaagg aaaaggatat ggcctgcctg ttaaacagag cggcattccg 1268881 gaagaatttt cgtttcgcgg gttagggccg gttgaactga ctgtgccata tgctgaacca 1268941 actttacacg tattgacgaa tattcttgga tttacagaaa tcagccgtga accagtcgaa 1269001 gggcaaggaa ccgccgttat tctggaatca ggagaaggcg gtgctgcaac ggaaatccat 1269061 ttaatagaaa gaaacgatct tccgcgagag cgtcaaggca aagggagtgt tcaccacgtc 1269121 gcatttcggg taagagatga agaagaactt gccgggtggc accggatcat cagccgcgaa 1269181 ggctttagca attcaggcat agttgagcgc tactatttca aggcgctgta tttcagagaa 1269241 ccgaacggca ttttgttcga gttatcaaca gacggaccgg gctttatggt agatgaaaat 1269301 cttgatgagc ttggccaaac gattgctctt ccgccatatc tagagcatcg aagagcagaa 1269361 attgaagcaa aattgaaacc gatccaataa attgtgattc ttttgccttc cggcgccgcc 1269421 ggagggcttt ttttattacc ataattaatt ttgacctaaa cagcatgcct tattagggag 1269481 gaaatatcag atgctgattg ggagaaatgg cttaaaaccc tttgcaaata tgggtgattg 1269541 gtatggaatg gcctcggcaa aaatattgtc tttgtttatt aatagtttat tcatatttgc 1269601 ttgttacact atttcaaagt tagacaaaaa ggagtgaaaa ataagtggaa aagaaaaaac 1269661 gcgagctgga tatcgtcctc ctcctcattt tgctcgcatc tgcattctta aatatctata 1269721 acatttggaa ggacgacacg gtgaatcctt attacaccgc ggcagttaca agtatgatgc 1269781 aaagctttca taatttcttt tatgcttcgt tcgatgctgc cggctttata acagtagata 1269841 aaccgcctgt tacataccaa atccaaacga tcagcgcact gatattcggt atgcacggct 1269901 ggagcgtcat cctgcctcag gcacttgctg gtgtaggttc tgtccttctt atgtacttgc 1269961 tgataaagcc gacatttgga aaaacggcgg cgcgtattgc ctcatttgtt atggcatgta 1270021 cgccgatagc tgtagctgta gcacgtacaa acaatgttga tgcattactg gtatttttct 1270081 tattgcttgc tacatggctt ctctttaaag cgatcagaaa aggaaagctg atctggctgt 1270141 tagcagcatt tttcgttgtt ggagtaggtt ttaatacaaa aatgctgcag gcttacatga 1270201 ttttaccggc tttcttattg ttctatctga ttgcggcaaa cgccacaatc aagaaaaaaa 1270261 tcgtttcatt ggtaagtgcg ttagccgtat tagcagccgt ttcgttatcg tggccgctca 1270321 ttgttgacaa tatccctgca agcaagcggc cttatatcgg aagcagccaa accaactctg 1270381 ttttggaatt ggctttcggc tataacggaa tccagcggct gacaggccaa aattcaggcg 1270441 gcggccaggg tgcgccaaac aaagacgctt caaaagaaat gtcttcttct gataacactc 1270501 aagcaccgcc taatcagtca tcaagcaaca gctcatcaag cgatggtaaa tcctcaaatg 1270561 gcaatatggc ggcgcctcca tccaatggcc aaatgccaag cggcggtcaa ggaggccctc 1270621 caagcggcgg agatggcggc caaggcggac ccggcggaga cggagggaaa ggcggtacag 1270681 gaaccggttc gaaaatgcaa tcaggttcag ggatgtttgg aacgggaaca cctggtccac 1270741 tgcggctttt ccaacaagag ttatctgatc aaatcagctg gcttctgcca tttgcgatat 1270801 ttggaatcgc aggcttactg atcgctggcg caagagaaag aagaagatta tctgtagagc 1270861 agaaggaaac ggtgttctgg gttgcgtggc ttgtaccgat tgccggattc ttcagtgtcg 1270921 cagaattttt ccatcattat tatctcatca tgctggcacc gccgattgcg gctcttgtcg 1270981 gtgcggggtg ggtcgctctt gttcatctgt accgcaatca gacaggctgg aaagcatggc 1271041 ttttgccggg agcaattatt gcgacaactg gatttgaatt gtttattctc agaaactaca 1271101 acgatcaaat cggtgttgga tggagtatcg gggtaggtgt tatcggcgtg ttgtcagcga 1271161 ttgctttgct gctgtttaaa cagcgccaaa aaccgttcag ttattatgtt tcacttgcag 1271221 ctctcctcgc attgctggtg atgccgatgt attgggcaag tacaccgctt ctgtacggag 1271281 gcaacagctc actgcctgaa acaggccctc aactcgcatc aatgagcgga aaaggcatgg 1271341 gaatgtctga tgcgactgta aatgaaaaac tgatcaaata tctagaggag aataactccg 1271401 gagctgaata cctattcgcc acaaccgatt cgaacacagc ggcaccatat atcattaaaa 1271461 cgaaaaaagc tgtcatggct attggtggat acagcggttc tgacccggca atcacactga 1271521 ctcaattcaa aaaacttgta aaagaaggaa aagtgaaata cttcttggct tctggaatgg 1271581 gaagaggcgg aaacaatgac attgttgaat gggttgagaa aaatggaaaa gaagtagcat 1271641 cagaaaaatg gcaatcaagt tctgatcaaa aaacagaaaa tactgattca gctgatacat 1271701 caagcagcaa ggcttcaggt gaaaacggca aaatgggcgg acctggcgga atgaatcagt 1271761 cagcaacatt atacgaacta catgctgatg aataggaggc aaaaacatga gcagacatat 1271821 tcaatattca attgttgtac ctgtgtataa tgaagagctt gtcattcatg aaacctatca 1271881 gcgcttaaaa gaggtcatgg atcaaacgaa ggaaaactac gagctgcttt ttgtcaacga 1271941 tggcagcaaa gaccgcagta ttgagatttt aagagagcac agcctgatcg atccgagagt 1272001 gaaaattatt gatttttcaa ggaattttgg acatcagatc gccattacgg caggtatgga 1272061 ttatgcacag gggaatgcaa tcgtcgtcat tgacgccgat ttgcaggacc ctcctgaact 1272121 gattttagaa atgattgaaa agtggaagga aggctatgaa gtcgtgtacg ccgtacggac 1272181 taaacgaaaa ggggaaacct ttttcaaaaa acaaaccgcg gctatgtttt accggcttct 1272241 cagcggtatg acagatattg atatcccgat tgatacgggg gattttcgcc tcatggacag 1272301 aaaagtctgt gatgaaatga agagattaaa agaaaaaaat ccatttgtaa gagggctagt 1272361 cagctgggtg ggtttcaaac agacagcggt cgagtatgta cgtgatgaaa ggctcgccgg 1272421 agaaacaaag tacccgctca agaaaatgct gaagctgtca atggacggca tcacgacatt 1272481 ttcacataaa ccgctgaagc tggcaagcta tgcggggatt ttaatgtcag gtactggatt 1272541 tctgtatatg tttatcgtgc tgtatctgaa gctattcaca gacagcacga ttaccggctg 1272601 gtcatcactt attgtgatcc agctcctgtt cagcggcatt gtccttctga ttttgggcgt 1272661 gattggcgaa tatatcggca gaatctacga tgaagccaaa gacaggccgc tttacatcgt 1272721 ccaaaaatcg tatggaattg aaaataaaag actctataga gaccagcata tgtcataacc 1272781 tcaaaccccc tgtccgtaat ggacaggggg tttttatgct ctgagcacga tctaaagcaa 1272841 aagatgctga tagatatatg gaaattgggt aaagaagaga ttgtgagctt gtactgcggt 1272901 tcagtcatgc tgaaataaaa acagcaaaac ttaaagattt cgtcctcggc tttgctgcat 1272961 gtcagctgtt atattggggg gcttttaaga aacgcatgat tagagccgta ccagttatgt 1273021 ttaatagaat actcgtaccc aatacaattc cccacgtcaa cgtcgattca gagagaagaa 1273081 agctcagcaa aagaaaagcc aatcctgcgc agatcatacc cagtcccacg gttttcatgt 1273141 tcatgcctcc tagcaaacga tgtttctagc atctgatgtg aatgatgtca atctgtatga 1273201 tatacggata tctcgtcaga aagtttcata gaacaattag gtcttttatc taataaaaag 1273261 cctcagaccg cttttacggc ctgaggcatt atgtcttacg aagttttctc ttctttttga 1273321 tccagtttaa tttttttcgt catttctttg ccgtttcgga gaattttcac ttcaacggta 1273381 tcaccgatct ttgcgtcttt atataagata ttgcgcaatt cactgcctgt atcaatttct 1273441 ttacctttta ggccgatgat aatatcctcc gcttttaatc cggccttttc agcaggagag 1273501 cctgaagcga cctcacggat gtaaacgcct ttattcagct ggctgccgaa caggccgagt 1273561 gtgccttctt ggtaattttg cggcacttgc tctagatcaa gcatgctgac accgatatat 1273621 ggacgttcaa tttgtccttt agacagcaat tcttcagcaa tcggttttac gtcattgctt 1273681 ggaatggcga atccgatacc ctcaacatca tcctcactga ttttcatact gttaatgccg 1273741 acaattttgc cgtctgtatt taacaaagga ccgccgctgt tacctggatt aattgctgcg 1273801 tctgtctgaa tgacgttaat gctcgtttcg ccggctgatg tagacattga aaccgttctg 1273861 tccacgccgc ttacaattcc ttgtgttact gtgcgggaca ggtcttttcc aagcggatcc 1273921 ccaatcgcaa taacggtctc gcctgttcta agatcagatg aatcaccgaa gtttgccact 1273981 tttgtgacgt ggtcatcact gatttggagg acggctaaat cagttaacga gtcactgcct 1274041 accagctttg cagtaacctc agtgccgtca tataaagata ccttcagtga tgatgcccct 1274101 tctacgacgt ggttatttgt aatgatataa gccttgccat tctctttttt gaaaatgaca 1274161 cctgaccctg aaccgctttc tgtatcttcg ctggaatcag aagaactaga gccgaacaaa 1274221 gagctgtttg attgtgcctg aagatttgta ataccgacaa tcgctggtga aaggtcttct 1274281 accatatctg agattttaga agagtcctcg ctcttgaatg cagatgagct gcttgagctt 1274341 tttttagatt cagaggaggt gcttgttgct gtaacagatt gcgtttgctg ctggctggat 1274401 gattgttttg cagtgtcctg agaatcatgg tcaccaagcg gtgtaaacgt gtaaatgcca 1274461 agagcaagac tgccgccgat cactccgcca agcaacggtc tgaaccatcc gaatcctcgt 1274521 tttttcttct cctgatcatg aatgacattg cgggccgagt aggaggcgct ctgatcgttc 1274581 tctttcgtta aaaagacctc attctcatta cctttcgttc tgttttcatc acgatagtta 1274641 tccatcatgt tcactccgtt tctctatttt cacatgtcta tttatattga taggtttatg 1274701 acttgagttt atcataaaca aaaactgtgg gataaaaatg aaaagattat gggaaattgt 1274761 gaaaaagtgc ggaaaacggt acacttcata ttgtatatga aaggactgag tcgatggaac 1274821 agattggatt gattggatat ggcagcatgg cggatatgat cgctagacag ctgttgaaac 1274881 atgaacaaat aaaagagaat gagctattta ttgagacgag aacgaagggg gagcggctgc 1274941 gggcactcat gtcagattat ccaaacgtat cggctgatcc gttggagaat tgggcaaata 1275001 cgtgccaatt gattttgata tgcgtcccgc cactccatgt catcgaaaca atgcgccgtc 1275061 tgtacccgta tgtgaacaga aatactcaca tcgtatccat agctgccggt gtgccgctgc 1275121 gtcttttgga ggcagaaaca gaagccggta tctcacgtgt tattcctgcc attacgtccg 1275181 aagcagaagc cggcatctca cttgtcgttc acagtgaagc actggctgca gagaaaaaag 1275241 aacgtctgaa tgaattgtta tcggttttca gccgtgtacg ggaaatcaaa gaatcgaatt 1275301 tagatgtggc cagcaattta acgagctcgg caccgggatt catagctgca atctttgaag 1275361 aactggcact gtctgccgtc agaaacagca gcctgtccaa agaagaagcc tttgattttc 1275421 tgattcattc gctatacgga actggcaaga tgctgatcga aaaaaatatg tctttcgagg 1275481 agacgctgga acgtgttgca accaaaggcg gaataacggg agagggagct gaggtgatac 1275541 acgcctctgt gccggacgtt tttgatgagg tatttgaaag aaccctgaga aaatatgaac 1275601 tgcttacaga acaggttggt aaacaaacat gaatccttga aagaggattc tttttttatc 1275661 actgaatgat tgagattttt cccagttata ttgcattttt cctctttttt taatataatt 1275721 tgttagaata ttcataattt agtaaaaaag gaggagcgtt atgaaattgt acatgtcagt 1275781 agatatggaa ggtatttcgg gtcttccgga cgataccttt gtggattccg gcaagcggaa 1275841 ttatgaacgc ggacggctta tcatgactga agaagcaaac tactgtattg ctgaagcgtt 1275901 taacagcggg tgtaccgagg tgctggtcaa tgacagtcat tcgaagatga ataatctgat 1275961 ggttgaaaag cttcaccctg aagcagactt gatttctggt gacgtcaaac cattttcaat 1276021 ggtggaggga ctggatgata cgtttagagg cgctttgttt ctcggttatc atgcgagagc 1276081 ctcgactcct ggtgtcatgt cacacagcat gattttcggc gtccgtcatt tttacataaa 1276141 cgatcggcct gtcggtgagc ttggattaaa tgcatacgtt gccggttatt atgatgtccc 1276201 ggtattaatg gtagccgggg atgaccgggc ggcgaaggaa gcagaagagc ttatcccgaa 1276261 cgtgacgaca gccgcagtca aacaaaccat ttcaagatcc gcagtgaagt gcttgtcgcc 1276321 tgcgaaagcc ggacggctgt tgacagaaaa aaccgcattt gccctgcaaa acaaggacaa 1276381 agtcaagccg ctcacaccgc ctgacaggcc agttctgagc attgaattcg ccaattatgg 1276441 ccaagcagaa tgggcgaatc tgatgccggg aacggaaatc aagacgggaa ctacaaccgt 1276501 tcaatttcag gcgaaggaca tgcttgaagc ctatcaggcg atgcttgtca tgactgagct 1276561 tgcgatgcgg acatcattct gctaaagggg tgttttaggc tttggcgcga tacatgataa 1276621 agcgtttttg ggcaatggca gctacgattt tggtgattac caccctgact tttgttctca 1276681 tgaaggtcat tcccggatct ccttttaacg aggagagagg cacaaatgaa gccgttcaaa 1276741 aaaatctcga agcctactat cacttagacg atcctctcat tttccaatac attttctact 1276801 taaaatccat cattacattc gatttcggac cttcaattaa aaaaccgtcg gacagcgtaa 1276861 atgatatgct ggaacgcgga tttcccgttt cctttgagct tgggatgaca gcgattgtca 1276921 ttgctgtgat ttctgggctg gtgctgggcg taatcgctgc actccgccgc aatggctttt 1276981 tggactacgc cgcgatgagt cttgcagtac tcggcatctc catcccgaat tttattctgg 1277041 caacattgct cattcagcaa tttgctgtca atctcaaact atttcccgct gcgacatgga 1277101 cgagcccgat tcatatggtg cttccgaccg cagcgcttgc tgtagggcca atggcgatca 1277161 ttgccaggct gacacggtcg agcatggtcg aagttctgac acaggattat atccgcacag 1277221 caaaagcaaa agggctttct ccgttcaaaa ttatcgtaaa acacgcactc agaaatgcac 1277281 tcatgcccgt cattaccgtc ctgggcacac tcgtcgccag catcttaaca ggaagctttg 1277341 tcattgaaaa aatctttgcc attccgggaa tgggaaaata ttttgttgaa agcattaatc 1277401 agcgggacta ccccgtgatt atgggaacga ccgtttttta cagcgtcatt ctgattatca 1277461 tgctgttttt ggtcgatttg gcctacggtc tcttagaccc gcgcattaaa ctgcataaga 1277521 aagggtgaag cgtgtgaatc tccctgtaca aacggatgaa cgccagccag aacagcacaa 1277581 tcaggtgcct gatgagtggt ttgtcttgaa tcaggaaaaa aatcgggaag ccgattcggt 1277641 caagcggccg agtttgtcat acacgcagga tgcctggagg aggctgaaaa aaaataaatt 1277701 agcgatggcc ggactcttta ttcttttatt tctttttgtc atggcagtta tcgggccctt 1277761 tttatcgccc catagtgtcg tacgccaatc gctgacagaa caaaatcttc cgccctcagc 1277821 cgatcattgg ttcggcaccg atgaactcgg ccgggatgtg tttacccgaa catggtatgg 1277881 cgcgagaatc tcgttgtttg tcggcgtgat ggcagcactg attgattttt tgatcggtgt 1277941 catttacgga ggcgttgccg gctataaagg cggcaggatt gacagcatta tgatgcggat 1278001 tatcgaagtg ctgtacggac tgccgtatct gcttgttgtc attttgctga tggtgctcat 1278061 gggaccggga ctgggcacga ttattgtggc gctgactgtg accgggtggg tcggcatggc 1278121 gagaattgta agaggccagg tgcttcagat taaaaattat gaatatgtac tcgcctcgaa 1278181 aacctttggc gcgaaaacct ttcgcatcat ccggaagaat ttgctgccga atactatggg 1278241 agcgatcatc gtacaaatga cattaaccgt acctgccgcc atattcgcag aatcattttt 1278301 aagctttctc ggcctgggca tacaggctcc gtttgcaagt tggggcgtga tggcgaatga 1278361 cggcctgcct acgattttat ctgggcattg gtggcgcctg ttttttccgg cctttttcat 1278421 atctctgacg atgtacgcgt ttaatgtgct gggggacgga ttgcaggatg cgcttgaccc 1278481 taagctgagg aggtagctgt atggaaaaag ttctgtcagt ccaaaatctg cacgtgtctt 1278541 ttacgactta cggcgggacg gttcaggcgg tcagaggggt gagctttgat ttgtataaag 1278601 gagaaacctt tgcgatcgtc ggcgaatccg gctgcggcaa aagcgttacc tcccaaagca 1278661 tcatgggcct gcttccgcct tattcggcga aggtgacaga cggcaggatt ctatttaaaa 1278721 acaaagacct ttgccgtctc tctgacaaag aaatgagagg tataagggga gccgacattt 1278781 ctatgatttt tcaagacccg atgacggcgt taaaccctac gctgactgtc ggcgaccagc 1278841 tgggggaagc gctattgcgc cacaaaaaaa tgagcaaaaa agcggcacgg aaagaggtgc 1278901 tttccatgct gtcattggtt ggtattccag atcccggaga gcgcctaaag caatatcccc 1278961 accaattcag cggcggtatg agacagcgga ttgtcattgc gatggcgctg atttgcgagc 1279021 ctgatatctt aattgcggat gaaccgacca ccgccctgga tgtaaccatt caggcacaga 1279081 ttttagagct gtttaaagag attcagagaa aaacggatgt gtctgtcatt ctgattacgc 1279141 acgatttagg ggttgttgcc caggtagctg acagagtcgc agtcatgtat gccgggaaaa 1279201 tggcggaaat cggcacaaga aaagatattt tttatcagcc gcagcaccca tatacaaaag 1279261 gcctgctggg ctctgtcccg cggctggatt taaatggcgc tgagctgacc ccgattgacg 1279321 gaacgccgcc ggatttattt tcgcctccgc cgggctgccc gtttgccgcc cgctgtccga 1279381 acaggatggt tgtgtgtgac agggtgtacc cgggccagac gatcagatct gactcgcaca 1279441 ccgtcaactg ctggctgcag gatcaacgag cagagcatgc ggtgctgtca ggagatgcga 1279501 aggattgaac atgaaaaggg ggaagaggat gaaacgagtg aaaaagctat ggggcatggg 1279561 tcttgcatta ggactttcgt ttgcgctgat ggggtgcaca gcaaatgaac aggccggaaa 1279621 agaaggcagt catgataagg caaaaaccag cggagaaaag gtgctgtatg taaataatga 1279681 aaatgaaccg acttcattcg atccgccgat cggctttaat aatgtgtcat ggcagccgtt 1279741 aaataacatc atggaggggc tgacgcgtct tggcaaagat catgagcccg agccggcaat 1279801 ggcggagaaa tggtctgttt cgaaagataa taaaacttac acatttacga ttcgggaaaa 1279861 tgcgaaatgg acaaacggag atcctgtaac agccggagac ttcgaatacg cgtggaagcg 1279921 gatgcttgat ccgaaaaaag gcgcttcatc ggcattccta ggttatttta ttgaaggcgg 1279981 cgaagcatat aacagcggga aagggaaaaa agacgatgtg aaggtgacgg caaaggatga 1280041 tcgaaccctt gaagttacac tggaagcacc gcaaaaatat ttcctgagcg ttgtgtccaa 1280101 tcccgcgtat ttcccggtaa atgaaaaggt cgataaagac aatccaaagt ggtttgctga 1280161 gtcggataca tttgtcggaa acggcccgtt taagctgacg gaatggaagc atgatgacag 1280221 catcacaatg gagaaaagcg acacgtattg ggataaggat acagtgaagc ttgataaggt 1280281 gaaatgggcg atggtcagtg acagaaatac agattaccag atgtttcaat caggggaact 1280341 tgataccgct tatgtccctg ctgagctgag tgatcagctg cttgatcagg ataacgtcaa 1280401 tattgttgac caggcgggtc tctatttcta tcgatttaat gtcaacatgg agccgttcca 1280461 aaatgaaaac atcagaaaag cctttgcgat ggctgtggat caagaggaaa ttgtaaagta 1280521 cgtcacgaaa aataatgaaa aaccggcgca cgcctttgta tcgcctgggt ttacgcagcc 1280581 tgacggcaaa gatttccgtg aagcaggcgg agacctgatc aagcctaacg aaagcaaagc 1280641 gaagcagctg ctcgaaaagg gcatgaagga agaaaactat aataagcttc ctgcgatcac 1280701 gcttacttac agcacaaagc cggagcataa aaagattgcc gaagctattc agcaaaaatt 1280761 gaaaaatagc cttggagtcg atgtgaagct ggccaatatg gaatggaacg tatttttaga 1280821 ggatcaaaaa gcgctgaaat tccaattctc tcaaagctca tttttgcctg attatgcaga 1280881 ccctatcagt tttctggaag cctttcaaac gggaaattcg atgaaccgca caggctgggc 1280941 caataaagaa tacgatcagc tgatcaaaca ggcgaaaaac gaagccgatg aaaaaacacg 1281001 gttctctctt atgcatcaag ctgaagagct gctcatcaat gaagcgccga tcattccggt 1281061 ttatttttat aatcaggttc acctgcaaaa tgaacaagta aaaggaattg tccgtcaccc 1281121 tgtcggctat atcgatttaa aatgggcaga taaaaactga tggaggcgat tgaggaaata 1281181 ctgcttcttt atgcgaagga gcggtatttt ttctctttct tgcacgtata cgtagggtgc 1281241 agagcaaatg aaaggagtgt tttcgttgaa ttacaagccg aaagcgttga acaagggtga 1281301 tacagtcgga gtgatcgcgc ccgcaagtcc gccggatcca aaaaagcttg acaccgcgct 1281361 tttattttta gaagagctcg gtcttcaggt gaagttgggc aaggcgctga aaaaccagca 1281421 cggctattta gcgggacagg atgatgagcg gctggcggat ctccatgaga tgttcagaga 1281481 cgatgaggta aaagcagtgt tgtgcgcatg cgggggtttt gggacaggac gtatcgccgc 1281541 gggcattgat ttcagcttga tccgcaaaca ccctaaaatc ttttggggat acagcgatat 1281601 tacgttttta catactgcca ttcatcaaaa cacaggtctt gtcactttcc atggcccgat 1281661 gctcagcacg gatattggcc ttgacgacgt tcacccgctg acaaaagcgt catataagca 1281721 gctcttccag gagacggaat tcacctatac agaagagctt tctccgctga ccgagcttgt 1281781 tcctggaaaa gcggaaggcg agcttgtcgg gggaaatctg tctttgctga cgtctacact 1281841 gggcacgcca tttgaaattg atacgagagg aaagcttctg tttattgaag atattgacga 1281901 ggagccttat caaatcgacc ggatgctgaa tcagctgaaa atggggggga agctgacgga 1281961 cgcggcggga attctagttt gtgattttca caattgtgtc ccggtgaagc gagagaagtc 1282021 tctctcgctt gagcaggtgc tggaagacta tattatttct gcgggcaggc ctgctctgag 1282081 aggatttaaa atcggccact gctcgccaag tattgccgtt ccgatcggtg cgaaagctgc 1282141 tatgaataca gcagaaaaaa cagccgtaat agaggcgggc gtttcagaag gggcgctgaa 1282201 gacatgaaaa tcattcgaat cgaaacaagc cgaatcgctg tcccgctgac aaagccgttt 1282261 aaaaccgcac ttcgcactgt gtatacggct gaatcagtca tagtaaggat tacttatgac 1282321 agcggtgcag tcggatgggg agaagcaccc ccgacgttag tgattacagg agacagcatg 1282381 gatagcattg aaagtgccat ccaccatgtg ttgaagccgg cattgcttgg aaaaagcctg 1282441 gcgggctatg aggccattct gcacgacatc cagcatcttc ttacaggaaa tatgagcgcg 1282501 aaggctgctg tagaaatggc tctatacgac ggctgggcgc agatgtgcgg gctgccgctt 1282561 tatcaaatgc ttggcggata tcgagatacg ctggaaacag attatactgt cagtgtcaac 1282621 tcacctgaag agatggcagc tgatgccgag aattatctca aacaaggctt tcaaacgctg 1282681 aaaataaagg tcggaaaaga tgatattgca acagatatcg cccgtatcca ggaaatcaga 1282741 aaacgtgtcg gatcagctgt gaaactgcgt ttagacgcta atcaggggtg gaggccgaag 1282801 gaagcggtaa ctgccattcg gaaaatggag gatgcgggcc taggcattga gcttgtcgag 1282861 cagcctgtcc ataaagatga tctcgctggg cttaaaaagg tgacagatgc aacagatacg 1282921 ccgattatgg ctgatgaaag tgtttttaca ccgcgccagg cgttcgaagt tctgcaaacc 1282981 cggagcgcag acttgatcaa tattaaattg atgaaagcgg gcggcatcag cggagcagag 1283041 aaaattaatg ccatggcgga ggcctgcggg gtggagtgta tggtcggcag catgatcgaa 1283101 acgaagctgg gcattacggc cgcggcgcat tttgcggcaa gcaagagaaa catcacacgc 1283161 tttgattttg acgcgccgct gatgctgaaa acagatgtat tcaatggcgg cataacatat 1283221 agcggcagca cgatttcgat gcctggcaaa ccgggcctcg gaatcatcgg ggctgcgctt 1283281 ttgaaagggg aaaaagagca atgatgcaca ctgtcatatc agcagtggcc aacatctgga 1283341 cagcgcctga ttcacctcgt ccgtctgatc aattcatgct tcaaccgact gtaatgatca 1283401 gagactggct ggagcgcatg acgtatgatg aacggcttgg attatgtaca gacaatgtaa 1283461 tccaaactca ggttctcttt ggcgaaaagg tacttgtgac ggcggaacag ggggaatggg 1283521 tttctgtgat cgtgcctagc cagccatccc gaaaggatcc gcgcggatac ccgggctgga 1283581 tgaaaaagta ccagctggaa aaaacaaagc ccatccatac acaacacgat gtgatgatca 1283641 gcaaacctgc tgcctttttg tacagaagca atggggaaaa ggagatcgaa ttaagctttt 1283701 tgacagttct gccccttatt gcaaaagaaa acggatattt taaggtttcg accgtttttg 1283761 gggaaaggtt tgtgaggcaa agtgatgcag tgcctgtcag ccaacagaaa gggactgctg 1283821 aagacatcat tcaaacgggt gcgttttttc ttggccttcc ctacctgtgg ggagggatca 1283881 gcgggtttgg gtttgattgc tccggattta tgtacagtat atttaaggcg aatggataca 1283941 gcatcccccg tgatgcggga gatcaggcta aggcagggaa gggtgtcccg cttgatgata 1284001 tgaaagccgg tgatctgctg ttttttgctt atgaggaagg aaaaggagcg attcatcacg 1284061 tcggtctgta tgtaggcggc gggaaaatgc ttcattctcc aaagacaggg aagtcaatcg 1284121 aaatcctcac attaacagag acaatctatg aaaaagaatt atgtgcggtg cgccgctgtt 1284181 tttcagaata aggagggaga caaatgaggc gactgccttt gttagaggtc agccagctga 1284241 aaatgcattt tgacgcaggg aaaaagcgga cagtcaaagc tgtcgacggg gtcacctttc 1284301 agattcgtga aggagaaacg ttcgggctag tcggggaatc agggtgcggg aaatcaacct 1284361 tggggagagt gctgatgcgc ctttatcagc cgacagaagg aagcgtgaca taccgcggca 1284421 caaatcttca tgcactaagt gaaaaagagc agtttgcctt caaccgcaaa ctgcagatga 1284481 tttttcagga cccttatgct tcacttaacc cgcgcatgac cgttcgagaa attattttgg 1284541 agccgatgga gattcataat ctctacaata cccataaagc acggcttctc gtcgtggacg 1284601 agctgcttga ggcagttggg cttcaccccg attttggcag ccgttatccg catgaattca 1284661 gcggcgggca aaggcagaga atcgggattg cgagagcact gtcgctgaat cctgaattta 1284721 tcgtggcgga cgaaccgatt tctgcacttg atgtctctgt tcaagcgcag gtggtcaacc 1284781 tgctgaagcg gcttcaaaaa gagaaagggc ttacgttttt attcattgcc catgatcttt 1284841 cgatggtgaa gcatatcagt gacaggatcg gtgttatgta cttaggacac atgatggaaa 1284901 ttacagagag cggcaccttg tatcgtgaac cgctccatcc ctatacaaag gcgcttttgt 1284961 cctcgattcc gattccagat cctgaattgg aggacaagcg tgagcgtatt ctcttgaaag 1285021 gggagctgcc gagcccggtc aatccgccaa gcggctgcgt gtttcgtacc cgctgtccgg 1285081 aggcgatgcc tgaatgtgga gaatctcgtc cccagcttca agaaatcgaa cccggccgtt 1285141 ttgtcgcttg ccatttgtat cgaaatgctg aaacgaagga aaaagtaaga taaataaaaa 1285201 gagtggctcc tttttactag agccactcca tttgtttata cttgatgtaa aaactttaca 1285261 caaaccgggt aagggacaga aaccgttgat gggaggagtg tcaatcggcc ggtttctttg 1285321 tctctttcaa acaagacaag gttgcctgtt tcttcatttg aagcaacgag gaacccttcc 1285381 gttgggtcaa atacaaagtc acgaggccag tttccttctg tcgacactct ttctacgaaa 1285441 gccagctctc ctgaatattg attcacttca aatacggcga tactgtcatg gccgcggttt 1285501 gcgacataaa caaaacgtcc gtcctgcgtg acatgtattg cgcttccctg gctgttatct 1285561 gtaaaatcat cagggatggc agaaacgact tggatttctc taaattcgcc ggctgtcggg 1285621 ttgtattcaa gcgcaatcac ttcattgctt aattctgtca tgacataagc gtatttttct 1285681 ttcggatgaa aagcgatatg gcgaggtcct gcaccgggag cgaaggaatg gcttccggat 1285741 tcagtcaaca caccgtcttt aagcttatag gtgtagagct tatctatacc taaatcaacc 1285801 gctaccacat aattgtgttc aggtgtgaac cccgcgtagt gtgtatgcgg tttttcttgt 1285861 ctttcgtgcg gcccttttcc tgtgtgagcg gcctctgaaa caggtgattg caagctgccg 1285921 tcttcctgaa ccggaaaaac gtgtaccttc ccgctgtgat aattggcagt cagtacgaat 1285981 tgattttgat catcaacgct tacgtggcat ggcgaagggc catcaattaa ctgatgattc 1286041 agaaatgtca attcgccgct gtttttatcg atttgatagg cagcaactcc gccttggccg 1286101 tctgcttttt cgatggaata aaggatggtg ttgtttttat tcgtcgccac atatgtcggg 1286161 ttgcccagct tagcggccag ctttggctcg ctgagtgctt ttttctcagt atcaagctca 1286221 aatgaataaa ttccttcgct tccgcctttt gtatatgttc ccacatatcc tatgtatttt 1286281 gtcatgcgat ttccccctta aaaatgatgt cacctctata ttaacgtatc ttgataaaat 1286341 aagctgttca aaacatgaaa aaggggaaga ttcttcattc gcctcgaatc agcggcattg 1286401 tgcagcacct gaaggagccg cctgatttaa taatttctga caggtcaatt tcgataatgt 1286461 gatagcctct tttcgatagc tgttgattga catggcggtt gccagggaga ctgatgatcg 1286521 ttttttttcc gattgaaagg acgttggtgc caagcgtaaa ttgttcgtcc tcgggcacct 1286581 caataagatc ataacgtttt gccagcatat cggctgcatc tggctcaatg gcctgtgaat 1286641 aaattaacgc ttcgctttca gatataatgt taaatacgca gtccaaatgc aaaaattttt 1286701 catgaagctt cactggaacg atcgtatatt caggaagtgc ctcttctagc tggccgatag 1286761 ctgaaatgtc ggtgcgctgg ctgattccga catagacaat gtcatcatcg ataatgacgt 1286821 ctccgccttc aatactcgta tcaagcatgc gggtgtaaga gataccttgg ctgtgaaaaa 1286881 aatcttttat aacggcttct tctccttggc gaatcggttc agtcatgctt gacagaaagg 1286941 ctttttctcc gatgacaaat cctatgtccc tagtaaaaac ctgttctggg agtccgtcgc 1287001 gaacgggcaa aaggacgacc tcaacgttgt gtgacctaag tgcctccact aagcggctgt 1287061 gctggtcgtt agcggttttt acatgaatat tgtcatcttc aaaatgtttt tgtgtttcgt 1287121 ttataacatc ttttatggtc atgtgctcag gtttgcataa gatcactttt tgaagtgtgc 1287181 cgtattccgt tcggcatacc gttttgtgct gagatttcgg gatggatacg tccatttgtt 1287241 tttcctccta aagtgtgaag aatacattta ttattccctc atcatgaaaa tcattaaacc 1287301 attttaaatt ttagacaaat ggaagagaat attgtttaat aggagaatat aagtgcattt 1287361 agctaaaaga tcagacatca aaggggagaa aggtatggaa acaccggaaa caagattttg 1287421 taaagagtca aaggttgtga aaaccagcag ggtgttcccg cttgacacga acaaccataa 1287481 tacgctgttt ggcggaaaat taatgagcta catagacgac attgcctcta tttcagcggc 1287541 gcgccattgc agacgtgaaa cggtaacagc ttcaatggat tctgtagatt ttttaaagcc 1287601 gatcgggcaa aaggattctg tctgcctaga gtcatatgtg acatgggtcg gcacatcttc 1287661 catggaagta tttgtgaaag ttattaagga gcatttgatg actggcgaac gggaactcgc 1287721 tgccacatcc tttttgacat ttgtcgcatt agattcaaat ggcaagccgg tgcctgtacc 1287781 gagggttgta ccggaaacag aagaagaaat catgctgcat aatacagctg tacagcgtgc 1287841 taatgaacgt aagaaccgca agagacacag ccaggcgctt gcaaatgcgc tcggaactga 1287901 taagccttgg tgaacgttaa acccaaaaca taagttgttt tgggtttttt tgtacttttc 1287961 aatggtgatt attacaatgg ttagtccgtt tttgctaggg gattctataa aaaagcaaca 1288021 aatgtcatgt taaattgata attttgtgac aactttatta aagattcatt ttagatatat 1288081 cttttattcg taagatcatg tattttaaag atatatttta aatacatctt ttcgaaagga 1288141 ttgtttataa aatgttagat aacaaaacaa tcgaaattat taaaagcact gtacccgtat 1288201 tgcaacagca tggagaaaca atcactggcc gtttttacga tcggatgttt caagaccatc 1288261 cagagctttt gaacattttt aatcaaacaa accaaaagaa aaaaacacag cgaactgcac 1288321 tggcaaatgc cgttattgca gctgcggcaa acattgacca attaggaaac atcattccgg 1288381 ttgtcaaaca aatcggccac aagcaccgca gtatcggaat taagcctgag cactacccaa 1288441 tcgtcggtaa atatttgctg attgcgatta aagatgtatt gggagacgct gcaactcctg 1288501 acattatgca ggcatgggaa aaagcgtacg gagtcattgc tgacgcgttc atcggaattg 1288561 aaaaagacat gtatgaacag gctgaagagc aagccggcgg ctggaaggag tataagccat 1288621 tcgttatcgc aaaaaaagag cgggaaagca aagaaattac atccttctat ttgaaaccgg 1288681 aagacagcaa gccgttacct gaattccaag cagggcaata tatcagcatc aaagtgcgga 1288741 ttcctgattc tgaatatacg catatccgcc agtacagcct gtctgatatg ccgggaaaag 1288801 actattatcg aatttcagtg aagaaagatg gtgtcgtgtc ttcctactta cacgatgggc 1288861 tgcaggaggg agattcaata gagatcagcg caccggcagg ggactttgtt ttagatcatg 1288921 catcacaaaa agatctcgtt ttgatcagtg ccggagttgg cattacacca atgatcagca 1288981 tgctgaaaac atctgtttcc aaacagcctg aacggcaaat tctgttcatt catgcggcga 1289041 aaaacagtga atatcatgca ttgcgccatg aagtagaaga agcagcaaaa cattctgctg 1289101 ttaaaacagc atttgtgtat cgcgagccga cagaggaaga ccgtgcaggt gatctgcatt 1289161 ttcatgaagg acagattgat cagcaattcc tcaaagaact gattgccaac acagatgcgg 1289221 attactatat ttgcggttca ccgtcgttta ttacggcaat gcataagctt gtatcagagc 1289281 tcggatcagc gccggagtct atccattacg agctattcgg cccgcaatta agtttggcgc 1289341 agtccgtttg aacacataca tgaaactctt ctcctttcag agaagagttt tttattgaga 1289401 tataagaagg cagacaagcg ccggtttcta catccggaca atcacagacc cgctgccatt 1289461 tgtgcataca cggttttgct gttcttgcat tgttctcagc aattcattgt ttacctcaat 1289521 cgctctaatt agttgcttca ttcttagctc caaaccggcc agcctgtcga ttgtttgctg 1289581 ctggtagccc tcgggttggg gagccaatgg cagatcaaag ggccaaaggg tattcgactt 1289641 ctgatttttc atattgcgta ttgcgcctcc aatcggtgtc actttctatt atgttatgtt 1289701 caggcgatat gcacgttcgc ctagacactg atgcatagag ggcctgccac ggggcacaat 1289761 aggctcaata tgaccagcgg atggaggtaa agatcggtgt tatggatggt atgggtattt 1289821 ttactgaagc cagttatcgt attttcgatt gcatatattt tgtttcggct tgccggtaaa 1289881 aaagctgtgt cacaaatgaa caattttgac ctgcttttga ccttcgcaat cggaaccatt 1289941 atcagtgagc cgatccttac atccaagctg ccgatgtcaa tttattatgc gggtgctttt 1290001 ttggtgcttt atcttatcat gagcaagctc tctttatcta ataaatggcg atggctccta 1290061 gtcgtgagcc cgactgtcct aatccgaaac ggggatattg atgaacgcgg ccttcgtaaa 1290121 gaaaggctga ctgttaatga gctgctcgga aagctgaggg aaaagggcta tgccgacccg 1290181 gctgacattg atcttgctat cattgaagaa acgggagaag taagcgtcat cccgaaagag 1290241 gaagcgagag cggtgcaggt gcgggatttg aatatggaag ctgaacggaa ttttatcccg 1290301 attccgctca tactggatgg cgaaatcctt gatcataatt tgaaatatct ccaaaaaaac 1290361 cgatcctggc tgtttgagaa gcttgaggaa aaagggtaca gccccaaact gctgtcttcg 1290421 attatccttg gcacgatgaa tgcacgcggt gatatatccc ttgatttaaa taccgctaat 1290481 gaaccgcagc atgatcctta cttatataaa ccgggaaata acaattaaga tggctctctc 1290541 ttgtaatgag agcttttttc ttttttaaag ggaatttttg tttggtgtca aatgtaccta 1290601 gttaggaggg gaactgaaca tgaaggactt atccataaga aacgacatgg cgccaacggt 1290661 cagtttgctg tattccgcag tggaagaaaa cagtctccgt ctggcttcca tcgtaagcca 1290721 tatgacacac agtgaacttt actataaggg gcgctgccaa acaaaaaaca gcacggctca 1290781 gcttttgcac catatcacaa atgttgatat cagatgggtc tggcgtatca aggaaaatcg 1290841 gatcccggac catattgaac aggcatacgg cccgatgaca gatgaaagcg gacggctgcc 1290901 tgaaccggtg aatcagccag acttagatga actcctgaaa agacatcagc atgtagtaga 1290961 gaagctgaaa tcggtatgct tcactttaac tgaaaatgct ttgaaccagc cgctttcctt 1291021 cgaaggtgac accgcgacga tacgatgggg aatttggcat atggcagatc ataaccgcta 1291081 tcatcaggca catattgaag ctctcaaaaa agaatggaag caggatgtgg cgaagtatga 1291141 acgctaaaac gaagcttgtg actgatcgaa ttcgtttgcg ctgtatggaa gatcgggatc 1291201 aagccacttt gtttgggctg ctttttaatg atcctgacgt catgacatat tattccggtt 1291261 taaaagataa gaggcaaacc cgcgagtggg tcaattggaa ccaacgaaat gaaaaagggt 1291321 acggcgttag tctgtggatc gccgaagata agcggacagg ggagtttttg gggcaatgcg 1291381 gcatcgttcc ccagcagatc gaaaatcaaa ccgtaatgga aattggctat atgtttgccc 1291441 gccgccactg ggggaacggc tatgcgcaag aagcggctcg ggcctgtctg gactatggct 1291501 ttaacgagcg gcagttcggc aaaatggcgg ctttgattga tccgggtaac aaagcgtcca 1291561 tacgggtagc ggagaaaatc ggcatgcatt acagcaaaac gatcagaaaa tggaataaac 1291621 cgatcgcggt atatgaaaga aaatcttaca attgaaagat agagctgagt ttagtatcat 1291681 gatatcatgt aaagttttct agggttccgc atgtcaattg acatggactg gtccgagaga 1291741 aaacacatac gcgtaaatag aagcgcgtat gcacacggag ggaaaaaagc ccgggagagt 1291801 caatctcatg tgagacgact gtccggggtt tttttgtttt cggagaatct taatagatag 1291861 aaaggaatga ctcaaaatga aatggggatt ggtcgtgctt gccgctgttt tcgaggttgt 1291921 ttgggtgata ggcttaaagc acgctgactc agccttaaca tggagcggca ctgccatcgg 1291981 catcatattc agcttttacc ttctaatgaa ggcgactcac agtctgcctg ttggtaccgt 1292041 gtatgccgtc tttaccgggc tcggcacagc gggaacagta cttagtgaaa tcgttctttt 1292101 tcatgaaccg gttggatggc cgaagctatt gttaattggc gtgctcttaa tcggtgtaat 1292161 cgggttgaag cttgtgacac aggatgagac agaggaaaaa ggaggcgagg cataatgctg 1292221 cactggatca gtttattgtg cgcgggctgt ttagaaatgg ccggcgtggc ccttatgaat 1292281 caatatgcga aagaaaaaag cgtgaaatgg gtgctgttga tcattgttgg ttttgccgct 1292341 tcattttcct tgctgtcgta cgcaatggaa accactccga tgggaacggc ttacgcggtc 1292401 tggacaggaa ttggcaccgc cggcggggcg cttatcggca tcctctttta caaggagcag 1292461 aaagacgcca aacggatctt ctttatcgcg ttgattttat gctcagcagt tggtttaaaa 1292521 attctgtcat aaattgattt ttatcaaatc ttcagtataa tggataaata gtttagactt 1292581 acaaagataa gagggattat tcatgaaatc atatatgact cagcggttgg acgaataccg 1292641 tgacggaaat gaggataaag gtcggctctt ggtcagctgc cccgatcagc cgggtatcgt 1292701 ctctgcagtt tccgcgtttt tatttgaaca cggtgccaat attatagaat caaatcaata 1292761 tacgacagac cctgaaggcg gccggttctt cctgagaatc gaattcgact gcgcaggcat 1292821 tcgtgaaaaa aaatcatcac ttcaggcagc gtttgcctct gttgcggaaa aattcgacat 1292881 gacatggagc ttaactttgg cgagcgaact gaagcgtgtc gccattttcg tttcaaagga 1292941 gctccactgc ctgcatgagc tgatttggga atggcaaacc ggcaacctga tggcggagat 1293001 cgctgttgtc atcagtaacc atgaggaagc gagagagctg gttgagcgcc tgaacattcc 1293061 attccactat atgaaagcga acaaagacat cagagcggaa gtcgaaaaga agcagcttga 1293121 actgctggag cagtacgatg ttgatgtgat cgtgctcgca cgctatatgc agattctaac 1293181 tcctgatttt gtttcggctc atccgaatcg catcatcaat atccaccatt cattcctgcc 1293241 agcttttatc ggtgcgaatc cgtacaaacg ggcctacgag cgcggcgtga aactgatcgg 1293301 tgcgacatct cattatgtga caaacgatct tgatgaaggg ccgatcattg aacaggatat 1293361 tgagcgtgtg gaccaccgcg ataatgcgga agcgctgaaa aacatcggaa gaacaattga 1293421 gcgcagcgtg cttgcccgtg ctgtgaaatg gcatttggaa gaccgtgtca tcgttcatga 1293481 aaataaaaca atcgtcttta actagactgc aagaggcccg cgcaatgcgg gctatttttg 1293541 atgacaaaaa accttgacaa gtgtcttttt tctttgcata atataaaaaa atcattgagc 1293601 gttgaagagg attagtaagc agacctttct gtgacagaga gcaaaatgaa tcgctgaaac 1293661 attttgccgc atgaaacctg ccgaacctgc cttggagtcc tagggggaaa acctaggcgc 1293721 ataacctggc gttacaggag agcggagcgt gcacaagcgc gttcaatcaa ggtggtacca 1293781 cggaaaccca tttcgtcctt atgaatcagg atgaaatggg tttttttatt gtagaagagc 1293841 cgcggaggag aataaatgaa aaaacaaaga atagtagtga aaataggaag cagttcgctc 1293901 acgaatagca aaggaagcat tgatgaggca aaaatcagag agcatgttca ggcgatttcc 1293961 gtgttaaaaa aagcggggca tgaaatgatt ctgattacct cgggtgccgt agcggcgggg 1294021 ttttccagcc tcggttatcc atcccgtccc gttaccatca aaggaaaaca ggcggcggcc 1294081 gcggtcggac aaacactgtt aatgcagcaa tatatgaatc aatttaaaca atactcactg 1294141 actccgggac aaatcctttt aacgagaaat gatttttcga aaagagaacg gtatcgaaac 1294201 gcgtatgcta cgataatgga attattagag cggggcgtca ttccgattat caacgagaac 1294261 gattctacat ctgttgaaga attgacattc ggagataatg atatgctttc tgcgttagtc 1294321 agcggattga ttcacgcgga ccagctcatg attctcactg acattaacgg actgtatgat 1294381 gccaatccaa atgaaaatcc tgaggcgaaa cgatttgatt atttgccaga gatcacgcct 1294441 gaattgcttg gatatgcagg ttcagctgga tcaaaggtcg gcaccggcgg aatgaaatca 1294501 aagctgttag ccacacaaac cgcgctgtct ctgggagtga aagtattcat tggaactggc 1294561 agcggagagc aaaaacttgc ggacattttg gacggcaggg gagacggcac ttatatcgga 1294621 gacaaagaac tatcttcggt taacaacaca aggcagtgga ttcagttcca ctcgccgata 1294681 tcgggagaaa ttatcattga tgcgggtgcc gaagaggcga tgatccataa tggaagcagc 1294741 cttttgcccg ctggagttgt gggcgtgaac ggaagctttc cgaaaggggc ggttgtggaa 1294801 gtcaggggac cgggcggcgt gatcggcaaa ggccaaactc attactcctc cgaggagatt 1294861 atggaggcta aaggcaaacg cagtgacgaa cttgattttg agaaaacgtt tgaggttatt 1294921 cataggaatg actgggtcaa tgtaaaagac taggaggcgg aaaaatgagt gaagtttctg 1294981 taaaagcgaa gctggcgaaa gaagcagcag ccgaaatgat catgaaaaca acagccgaga 1295041 aggatgaggc gctcagcctc attgcaaacg gactccgcaa agaactggat tttctcttgg 1295101 cggagaatgc aaaagacatt gtgaacggaa aagagaatgg tttaacaccg gacatcattg 1295161 accgtctctc attggatgag aaacggatac gcgatatcgc ggacgcggtg gagctcttaa 1295221 tcgacttagc ggacccaatc ggcgactctc ttgaaacgat tgaaaaagaa aacggcctgt 1295281 ttattgaaaa aatccgtgtg ccgctcggtg tcgtaggaat gatttatgag gcgaggccaa 1295341 acgtcacagt tgatgcggct accctttgcc tgaagacagg gaacgcggtt gtgctgcggg 1295401 gaagctcctc agccatccac agcaacaaag cgctcgtcag tgtcatttac agagcacttg 1295461 agcaatcagc gcttccgatt cacgctgtgc agctgattga ggatacgagc agagagacag 1295521 caaaagagct ctttacgtta aatgatggct tagacgtatt gattccgcgc ggaggcaaga 1295581 aactgattga tctcgttgtg agagaatcaa cagttcctgt attagaaacg ggagcaggaa 1295641 actgccacat attcattgac gaaacagcca aaccgcaaat ggcagaaaag gttgttgtaa 1295701 atgccaaaac gcagcgccct tctgtatgca acgcgattga atcattgctg attcacaagg 1295761 cttgggcaag acagcacgga aaagaattgc tggaccagct ggaaaacgcg ggagttgaaa 1295821 ttcgcggtga tgaattggta tgtgaacttc atccttcaag caaacaagca tcaaaagaag 1295881 attgggaaac cgaattttta gcgcctgtcc tcagcgtaaa gacggttgaa aacgtccaag 1295941 aagctgtaaa gcatatccaa caatacggca ccaatcattc tgaagcgatt ttaactgaaa 1296001 atgacaaaaa tgcggtatat tttcaaacgg ctgtcgatgc tgccgctgtc tatcataacg 1296061 cgtcaacccg ctttaccgac ggctttgaat tcggctacgg agccgaaatc ggcatcagca 1296121 cgcaaaagct tcatgcaaga ggaccgatgg ggcttcctgc actgacttct acaaaataca 1296181 tcattaaagg aactgggcaa atccgtgaat agcggggtaa tgttcaatga aaaagcttat 1296241 ctcattacga gataagcttt tttatacgcg aaaaattgac atttcaaatt taattgtgta 1296301 caatttaatt gtataaaata tattggggga atgaaaaatg agtcagccat tatttaccgc 1296361 aactgtttca gcggtaggag gaagagaagg aaaggtcatt tcatcagacc gcgttcttga 1296421 gcttgatgtc gcaatgccgg ggacaccgag agccaagaaa ttagaaaaag cgacaaatcc 1296481 agagcagctg tttgcagcag gttatgcagc ttgctttgac agcgccctgc agcttgtcgc 1296541 aagaacagaa cgggtaaaag tagagacaga ggttacagca aatgttagcc tgttaaagga 1296601 tgaagcggac cagggctata agctgggtgt gacgctgcaa gtaaaaggag aaggagtcag 1296661 tgcatcagaa ttggaggcgc ttgtgaaaaa agcgcacggc gtctgcccgt actcaaaagc 1296721 aacctccgga aatattgatg tgacacttga agttgctgaa taaataaaaa gaggatgcct 1296781 gtacaaggca tcctcaattt ttttgatgaa gtgtttccag taatgtatat agagcggact 1296841 ttaactgttt gagatcctcc ccagactgct ttgagagccc cagaattgtc cctggaatgt 1296901 caaccgcttt ttcttttaat aacgctccgt cctctgtcag gctgatcaac acggaccgct 1296961 catcctcttc agatcttttt ctcgtaatca aaccctgttg ttccattcgt ttaagcatcg 1297021 gagtgagcgt tcctgaatct aaatacagct gttcgcccat ttttttgaca gtaagcgttt 1297081 catgttccca taacaaaagc aaagccaaat attgagggta tgttatattc agcttatcaa 1297141 gcagcggctt gtattgcttt gtcatctccc gcgaactcgc atatagcaaa aaacaaagct 1297201 gattctccaa tttcatatga tcaaatttat tttccatttt gttcaccaac tcttttttgt 1297261 cattcgattc tattgtatct gaaaaacctc acttttccta ttctcggcaa acatagcatg 1297321 tttaaaaaga tcagaaaggg aaatataaca actagataca aataaggagg ttgggaaata 1297381 tggcactatt tacagcaaaa gtaaccgcgc gaggcggacg agcaggacat attacatcag 1297441 atgacggtgt tcttgatttt gatattgtca tgccaaatgc caaaaaagaa ggacaaaccg 1297501 gcacaaatcc ggaacagctc tttgcggcag ggtatgctgc atgcttcggc ggcgcgctcg 1297561 aacacgtagc caaagagcag aatatcgaaa ttgattcgga gattgaaggg caggtcagcc 1297621 tcatgaagga tgagagcgac ggcgggttta aaatcggtgt cacacttgtt gtgaacacga 1297681 aagatttaga tcgggaaaag gcacaagagc ttgtcaacgc cgctcatgaa ttctgtcctt 1297741 actcaaaggc aaccagagga aatgttgatg taaaactaga attaaaataa tgaccggcat 1297801 cctgaggatt ctcaggatgt tttttggtgt cggacatgcg gggcgggcac agatttatga 1297861 taaaacttca gagaagcgtt tgaagcatgc ctttaaacca aaagttacag atgaagcggg 1297921 tggctggcac ggtgtctgcc gtgctgaatt gcgcgtatat gctgttttgt atttgcacag 1297981 ggcatagcgg ctacttggag aaataacaag gaccaggccg cgcatgcctg atccttttaa 1298041 tattctttct tattggcgaa gttccgccat gcttgaaacg gggataaatg ctctgttagt 1298101 gtcacttgat aaaaggggat cgttctttct tcagcaggtt tatcaatttc tttataaatg 1298161 aatgaatcat caaacccggc ttcggcagcg tctgtgtgct cagctgcata gaaaacggct 1298221 ttaggccggg cccagtagat ggcgcccaag cacattgggc atggttcaca gctcgtatac 1298281 aaaatgcagt catcaagctg gtaggctcct agcaccttac aggctttccg aatagctgtg 1298341 acttccgcgt gggcagtcgg atcattgctt gttgtgacgt tgttctgtcc ctctgcaata 1298401 atggctccgt ctttcacgat aacggctcca aaaggcccgc cgattcctgc attcactcct 1298461 tcacatgcga gagtgacagc ccgttttaag aacgtttcat gattcatccc aatccctcct 1298521 gtcaatagag tgttattagt atagccgaaa agaatgcaaa gaacattctt aaaaaagtgc 1298581 aaaataaaca aagtatttgg gggatttgct aaataagaaa ccgattgtgg ctgtattata 1298641 gaaaaaaacc atctgccaaa tgcagatggt tttttcaaat tatactagct gtgtctgctg 1298701 tgctcttgcc tgttttgcgg cttcaaccat atttttcaat gctgcaaccg tttcttcctg 1298761 ctgtcttgtt ttcaatccgc agtctggatt tacccagaag cggtcagtcg gacagacggc 1298821 aagcgcatca acgataatat tgtacatttc ttcagttgac ggcacacgag ggctgtgaat 1298881 gtcatataca ccaaggccaa gccctttcaa atacgggtgg ttttttaagt aatctaaaaa 1298941 tcctccgtgg cttctgctat gttcgattgt aatcacatcg gcatcaagat cattgattgt 1299001 atcaacgata tcttcgaagt tgctgtagca catatgtgta tgaatttgtg tctcgttttt 1299061 cacggaagaa gtggttaatc tgaaagcttc tgccgcccaa gtcaaatact catcccaatc 1299121 gcgggttttc aatggaaggc cttcacgcag cgctggttca tcgacttgaa tgatttgaat 1299181 gcctgcgtct tcaagcgctt taacttcttt gcgaagggca agcccgattt ggaaggcgat 1299241 ttctttcctc gagatgtcgt ttcgagggaa agaccagttt aagattgtaa ccgggcccgt 1299301 cagcattcct ttcacatgct tggaagtcaa tgactgtgcg tagactgtgt ctttcactgt 1299361 catcggttca ataaattcaa catctccgta aatgactggc gggcggacac agcgtgagcc 1299421 gtatgattga acccaggcat atttagtgaa ggcgaaaccg gccagctttt caccgaagta 1299481 ttcgaccatg tctgtccgtt caaattcgcc gtgaacaagg acatcaagct ccaattcttc 1299541 ctgaatatca atccatcttt ttgtttccgc attgataaag ttttgatact gttcatcgga 1299601 ccactcagct ttccgccatt tttggcgtgc gctccgcact tcagcagact gcgggaagct 1299661 gccgatcgtt gtcgtcggca aaagcggaag gccgagagat tcattttgta gggctaaacg 1299721 ttcttcaaac ggaatcgggc gcttgaagtc tttatcagtt aattgctcaa gctctttctt 1299781 ttgttcagaa ttggcgcctg ttgcaaactg tttaagcgcc tggatatcag ccttagcctg 1299841 ctgaatctct tcgctgatcg ccgcttttcc tgatactaag ccttctttca aagctgtcag 1299901 ctcggccagc ttttcttttg cgtaggataa tccgttcaat aggtcttttt ccaaatgctc 1299961 atcagggtgt ttcgctactg gaacatgcag caggctgctg gaaggctgaa tccacagttc 1300021 atcaactttt gcaatgctga gaatatcaag aacggcatcg agacgctctt caaggtccgc 1300081 tttccaaatg ttgcgtccgt cgataacgcc ggctgccagc actttatctg tcgggaagcc 1300141 atgtgtttta agctgttcca ggtttctgcc tttgtcgtga acgaaatcaa ggccaattcc 1300201 ctgaaccggg taagagatca gctcttcata agcatcaaca gaatcaaaat acgtctgcaa 1300261 aagcacattc aaggatgaaa gctcacttgt aatgctttca aataattctt ttgcgccgcg 1300321 tacatcttca ctagaggcgg taacgagcgc cggctcatcg atttgaaccc attttacgcc 1300381 ttcttcttca agctctttca aaagctgtac atataatggc acaaggcgtt tttggatcgc 1300441 ttttgcttca gacggttcat agcctttagc aagcgtaacg aacgtataag ggccgacaat 1300501 cacaggcttt gtttccacac cgtattcctg tttgatccgg cgataatctt cgagttgttt 1300561 gtttcttgtc agacggaact caatgctctc gtcatattcc ggaacgatgt aatggtaatt 1300621 tgtattaaac cattttgtca tttcactaga tacagcgtct ttgattccgc gggcgatagc 1300681 gaagtatgta tcggtagcgt cagtcaaatg tctgaaccgt ttcgggatcc agttgaagct 1300741 gactgctgtg tcgagtacat ggtcatactg tgtgaaatca gaaacaggca caacatcaat 1300801 ctgctggtca atttgtgttt ttactgcgga taaaaatagt tcgtcgattt gcttcaaaaa 1300861 cgtatcttta tcagtactgc ctttccaata cgcttcaagt gcttttttcc attcccggtt 1300921 cagtccgatt ctcggaaatc ctaaattcga tgttttgatg gttgtcattg tttctcctcc 1300981 tttatatgta aaacactctc tttcacccgc ggatacaggc tgctaagagg ttttctcaca 1301041 acaaaaagcc tctttcccat gagagaaaga ggcttttcta cgtaaaacac tgcctctctc 1301101 atctctcaga cacaatctga tggaattagc accgtgcctt atgagacatc agtctcggcg 1301161 cgaaaagcag tgcgccccat ttcacaatgg tattacggtc ggttgctgtt ggggtcaaaa 1301221 ggccaatccc tcgcccaact ctcgataaga gaaaatgtta ttaatttttt gaaaagttga 1301281 atcatttgtt ggtaatctta acagtaattc aaattcattg tcaacataga atttgaaatt 1301341 tttatttaca tgatgtggtg tatattatat aagaaaaata atcttatagg gtcaacaaat 1301401 gtgattgctc tgctttttct gcgagctcat caggagctgt taaatacagg aatccattgc 1301461 ctgccagcgt ttttgcaata tcaagaggaa gtgtcctgcg gattagctgt gcgaaaacct 1301521 cagattcaga aagctttctt tgaaatgatt cttcttcata gcttttgatt aaagcaagcg 1301581 caccgctgac atgaggggca gccattgaag tgccggtcag cttaccgtac ttcttgttgg 1301641 gaagggtgga taagatgttt tctcctggtg ccacaaggtc aatctcttta ttcgcgttag 1301701 aaaattctga taattctcgc gctacagaaa cagatccaac tgcaatcact tcattataag 1301761 ctgcggggta ggaaagctct tctgtgcgtt cgtcgccgtc accttcattt cccgctgcac 1301821 aaacgacaag cactccgttt ttcactgcgt ttttcactgc ttcttttagc tctggcacat 1301881 cgcttggccc tccaagggac attgagatga tgtcgacttt ctgttccacc gcgtagttga 1301941 tgccgttaat tatccattcg tattgtccgc tgccgttctc gccgccaaga accttcacaa 1302001 tcaataggct tgcctcaggc gcgactccgg caatgcctcc gtttgaatca ttagctgcaa 1302061 ttgttccggc gacgtgtgtg ccgtgtccgt tgtagtcgga aatcgcatct tccttgccgc 1302121 cgtcgtcatc cgtgaagttc tttccgccga tgatttgatt ttttaaatca gggtggcttg 1302181 tgtcgcagcc tgtgtctaat acagcaactt taatattttt gccttttacc ccttttgccc 1302241 acatttctgg cgccttaatc actttaatgc cctcaggaag ctcgtttaca tccatgatct 1302301 gctcattcgt cacatacggg atcaagcgga tttcaccatt cataaaaaag ccctcctttt 1302361 ttatgcttgc aagtggattc aagggtgttg cctcatatta tatgaaaaaa gcaagcgctc 1302421 ggacagagcc atttgaagca ttttgaaaaa ataggataca caccaaagaa ttagtaatct 1302481 tcaaaatatt ggatggcttc aacatgtatg actgggattc aactgtaagt caagttataa 1302541 tagtgttggg gaaaggagca gtgtcatgaa actgaatgaa aaattatatg catttttttc 1302601 agagcatgtg gaacaaatgg ccgaggaatg gattgaaacg atggaggaaa gtgatccgaa 1302661 ttcgctttac gccctacata atgcaacagt aacggaagaa ttgaaagagc aggacagaga 1302721 attttaccgg catctgaatt acatgtatgt tttaccggaa aaacaatttc tcgaagagtt 1302781 tcaagagtgg gtcattgagc tgaccaacga tcaaaaacat ctcgacacac cggttcagta 1302841 tgtcattcgg gagtttatga gaaacaggag attatatacg aagtattttg agaagttcgc 1302901 agaagaaaat gaatcagcgt ttgaaccggg agagaagcaa aaatgggcag atttgattgt 1302961 aaaagtattt gatttcacca tttatacatt cgttgatcac gctgaaatga atgccaagca 1303021 gcaattaaac gcccaaagag aaatgatatt ggaattaagc tcacctgtca ttaccctgag 1303081 caaatcaaca gctctgctgc cgcttgtcgg tgacattgat accgaacggg cgaagtttat 1303141 tctggaaaac acgcttcaag cttgtgcgaa aagacgtgtg gagcatctgt taatcgatct 1303201 gtcaggtgtt gttgtggtgg atacgatggt ggcgcaccag atctttaaat tgattgaggc 1303261 gcttaatctg atcggtgtcc ggtcaaccct gtcaggaatc aggcctgaaa ttgcgcaaac 1303321 tgctgtacag ctggggattg acttttcgaa tattactatt aaaaccaacc ttgcccaagc 1303381 attaaactat catcaataaa aaaatccgct atctgtgata gcggattttt tatgatgcga 1303441 aacataaaga tacgagaaag gatcccgcga ataataagag gacgaggcaa aagaacaccc 1303501 agtcgcgccg gttcacgctc aatgtcctgt agtatgtccg gtttctgctt cctgtaaatc 1303561 ctttcgattc catcgcaagc gctgtccgtt ccgcttttct gatggcgctt gccaatagcg 1303621 gtatggtata tcgttttaac gcactgattt tattaatgat gccgctctcc gccgctcctc 1303681 ctctgatttt atgagcctgc tgaatcagct ggacctcatc ctttaacagc ggaagaaagc 1303741 gaaagcctgc aatgacaccg tacgcgagct ttggtgagag cctgcactgc tggacaaggc 1303801 tcagcataaa tagaatcgga tcggttgtaa aaacaaacat catcgataag gcggaaaagc 1303861 ataaaatacg aaacccgaga gagatgccga cagacacatt atcgctgtta atggagatag 1303921 ggcctgcttg aaacaaaaaa ttatccggtg ttgtcggcac ttttccaaaa actgcggctg 1303981 tccacacgca tccgaatgct aaaatcaaaa acggaatcgt aaacaacaac cattttttca 1304041 atgggattcc ggccgccagt aaaacgcccg caacgatgat gatataaaaa catgccggag 1304101 tgtaagggtt gtaaataaac gacagcatga cgacacaaca aaaaaccgcc gccgctttca 1304161 cagtcggatt aatgagatgt aacggttgct tcatcacgca cctcctcttg aaatgccatc 1304221 cattcatata gaaggggaag ggtgagcttt gctttttgaa caagccctgt ttcttgagaa 1304281 aacaactgcg ctggagatcc gtcaaaggcc aggcctgtat cgtgaagcac aagcacgctg 1304341 tcagcatacg aagagactag ctccatatcg tgtgtaatca taaggacagc agttccctct 1304401 gccttgatac gttgaatcat ttccatgcat tcagccgccg tgcgggcatc ctggccaaag 1304461 gttggttcgt ctaataataa aacctttacg tcatgcatga gcatagtagc tacgctcagt 1304521 cgccgttttt gcccttggct gatcgcaaac ggatgatgat cagccaaatg cgcaagacca 1304581 aaacgctgca gcaggtgttg cgcttttttc tcagtttcag catttgcttt ctggccgaac 1304641 agaagctcgt catacaccgt atcggtgacg aattgatgct cagggttttg aaaaacaaat 1304701 cccatccgtt tacgcaattc tttttcttta tatttctgca gcggctgatc atagagaagg 1304761 attttgccgc tttgcggttt catgagactg gccagaactg ataggagcgt cgattttcca 1304821 gttccgttcg gaccgacaag cgccgttaaa gagccttcgc gcaacgaaaa gctgatgtct 1304881 ttgaaaatcg cctgctgtcc tctcgcgaac gaaaggctgc tgacttcaag cacactctcc 1304941 ccagaagggg ctttcttctt tttgacatgc ccggcaggaa taggctcttt gaacagcatc 1305001 tcttttgata aagtaaacgg catactcagc ttttcctgca gatgacagac ctttggaatg 1305061 gcgatgccca atttctttag tgtctccgct tcatgctgaa atagattttt cgtcaggcca 1305121 tccagtgcct ttttgcctga tttgtcgagt acgatcgttc tctcaatcca aggcgcccat 1305181 tcatcaagct ggtgctcaat gacgaggagg ctgaaacctt tttcccgctg aagatccttc 1305241 atcagatgaa cgaactcccg agctgagaaa gggtctaaaa gagaggtcgg ctcatctaaa 1305301 ataataagct caggctccat cgccaaaata caggcgagag ccactttctg cttttgtcct 1305361 cctgaaaggg ttgagatcat tttttctttt aaatgggtaa tgcgtaattt ttctaatacg 1305421 gcgttgattt tctctgtcat ttcttctttt ggaatttgca gattttccag cccgaacgct 1305481 atttcgtcct ccaccgtcag catgcagaac tgctgatcag gatcctgaaa aacgaccccg 1305541 gcatgctgag taatcgtttc ggaggtttca gcatctgtga ccggcttttg aaatagaaat 1305601 acatgtccgg actgaatgcc gtcgcaagcc tccggatata gaccgtttaa acaaagggcg 1305661 agcgagcttt taccgcatcc gctcggtcct aataataaaa cacattctcc tttttgaagc 1305721 tcaaacgaaa tgtcttgaaa aaccggtttc tcgtcttctt cataagagaa gctgagctgc 1305781 tcaaccgtca gaagctcatc aaaggcttgc atgttctgac gcccgcttcc gtttcttttt 1305841 cagttccttt ccgagtgcca ttccgtttaa cacacctgta taagcgagag agtcgctgac 1305901 agcttttccg agaagccccg ccaaaagcgc gccggaaatg aggcggatca caagcataat 1305961 gagcagataa cctggtgaat aggctgcata gccagaaaca aagagatcat agataaagct 1306021 ggctactgaa gaccccatac cggccagcat aaggacaggg agagagtatg ctttccagcg 1306081 tgttgcaaga aatacagcct cagccccgag cccttgaaca atgccaatga cgatgaccat 1306141 cgggccagac ggatttccca gcaggcactc aacgagagcg gcaatgattt cagaaacgag 1306201 cgccgcaccc ggttttcgaa tcatgtacgc ggcgatcaca gaaacgataa accaaatgcc 1306261 gtaaattggt tcataggcga ttggcccaaa catacctgca agtacgtttc cgaaatgtgt 1306321 aaataataaa taaacaacgg caaatacgat actgataacg gacatgatga caatttcttt 1306381 tactttccag cttttcatgt tatccctgct ttctgttttt tcttgatgga ctgttagccg 1306441 aaagattcac agtcatggtg atgtggtttg tttgctgctc agccatgcgg aaaacggcct 1306501 ccaatgtgct gaatacgtca tgcgcatccc cgtcaagctc gctcgcgtaa tggacaccct 1306561 gtacgaaagt gccttgggct tttgcaatgt cgacagcctc cataatcaat cccatataat 1306621 ccggctcatt cattggataa agggcaaatt ggcacggcgc ttccgccttc aagcctcgga 1306681 cagcatcttc attgacacgc ttatcacctt tggaaagata tgtatccccc tgtgtgtcac 1306741 ccgggcatcc aatggaaaac gtgccgttca tgacgatgtg ttgttcgctg tttgctgcat 1306801 gaaggtaaat ggcttttgca gcatcgaata catgatcaat cgatccgcgt aacaccgtgc 1306861 tgatatggtc ggttttcgtc caaaccttgg atgtatctgt ttttttcagc gcagacttga 1306921 tcacactgat aaaatcatcc gtcatcggat ataaagagaa gcgaaaaccg gcgattctgc 1306981 ttgtaccgca aatatgctcc atttctccga cctcctgttt ttttggtaaa ataaaaaact 1307041 gcatatccta agggaatatg cagtcataga tcgattaagc gcacaaaaaa atacaccatt 1307101 cggtcaacct gcacttcccc acgctggtat tatccagatc gggtcataag ggatcaaagc 1307161 gcgtttcttc cgcgctttat ctcagccaaa acagcacccc tagtgctttc cgtatacaat 1307221 tttttatttt gacatcataa tagatgataa gaatcatttt gtaaacaacg aaatcatttt 1307281 tttcatatag ggacgggaga ggatggtcaa atttggaaaa aggacacata ttaattgtgg 1307341 aagatgaaga aaaaatcgcc agggttcttc agcttgaatt ggaatatgaa ggatacagcg 1307401 tcacgatcaa acacaatggc acagaaggtc ttgatgcggc agcggaaggc gggtattcct 1307461 tggtgcttct tgatgtcatg cttccggggc ttagcggact ggaagtgctg cgccgcttga 1307521 gaaaaacgga ttcgcagaca ccggtcatat tattaacggc gcgagacagt attcctgata 1307581 aggtaacagg tctggacatc ggtgcaaatg actatgtcac caagccgttt gaaatcgagg 1307641 aattgcttgc gagaatcagg gcggcgctgc ggcaaaatgg aacaaaaact gaagatatcg 1307701 gcacctttct tacatatgac gatttgcggg tgaacgaaaa aacccgtgaa gtgagacgcg 1307761 gagacaaaga ggtggaatta acgccgcggg aatttgatct gctcgtctat atgctaaagc 1307821 atccgcagca agtgctgaca cgggagcaaa ttctaagctc agtatgggga tttgattata 1307881 tcggtgatac aaatgtcgtg gacgtctaca taagatacat cagaaaaaaa ctggactatc 1307941 cttacgaaaa acagctgatc catacgattc gcggggtcgg ctatgccatt aaggggtaaa 1308001 cgatgaagct gaagaccaag attcatctat acacttcgat atcactgttg attttattaa 1308061 ttttggttca taccgcagta tatctcattt tttcgtctgc gctgacatca aaggatgcgg 1308121 cccggcttgc tgatgagacg gataacattg ccgaagcgct gcgtgccgct gaaacagaag 1308181 gagtggcttt gcaggatatg ctgcaggcct atcttccggc aaatggcatg gtgcgtgtag 1308241 tgaatggtga tcaaaaagcc gttatgacga tcacaaaaga aaaagcctat aaagattttc 1308301 ctctctcttt tcatagcggc gaaacggcag atgtgaggaa acctgacggc aagctgtttg 1308361 ccgaggctgc tgttccggtg atttggaccg atggacaagt cgtgtctctt cagctggttg 1308421 aaagactgga gaacacagaa gagagtctgt ttctgctgaa aatcatctta atcgctgcaa 1308481 gtgctgctgt ctgcattgct tctttttttg caggcagctt gctagcccgc cgaatcatca 1308541 atccgatcag acgattaatg atcacaatga aagacataca gcgagacaaa gaatttaaaa 1308601 cgatttcttt agaaggacag tccaacgatg aattgtatca aatggggctg acatttaatg 1308661 aaatggcaat gatgctgaag gagcactatg ataaacagca gcaatttgtt caagatgctt 1308721 cacacgaatt gaaaaccccg ctcactatta tagaaagcta cagcagcctg atgaagcggt 1308781 ggggtgcaaa aaagccggag gtgcttgagg agtcgataga agccattcac tcagaagcgg 1308841 tgcatatgaa aaaactgacc aatcagcttt tggcgctggc caaaagccat caaggactcg 1308901 aggttgatct gaaaacaatc gatctgatta aagcggcgcg cgcggttatg caaacgctcc 1308961 agtccgttta tcagcgtgac atattgcttg aaacagataa agagagcctg cttgtaaagg 1309021 cagatgaaga acgcatcaag cagctgttga ccattttgct tgataatgca ataaagtata 1309081 gtgaaaagcc tattgagatg tcagccggaa cgaggaatgg acggccattt ctatcagtga 1309141 gggatgaagg catcggaata cctgaggagc atatcccgca tttgttcgaa cggttctacc 1309201 gggcagatga ggcacgaaac agaaaaacag gcggaacagg tttaggcctt tccattgcca 1309261 agcaaatcgc tgatgagcat ggcattgagc tgtctgtcaa aagcaagccg ggacaaggaa 1309321 cagctgtcac catgcaattc agcgaacaga atgggggagg ccgatgacta aaacaataaa 1309381 aacagtatct tttgctgcag cagccatttt agttgtcatc atctgtacgt ttctcatcat 1309441 tcggcaaacc catgagaacg tattgtcaaa ggagactgtc gtaaaaaaag tcgaagcctc 1309501 ttatgaaggc aaggtcacga aagcaacaca atcaaaggat aaaaaaacat atgatataac 1309561 ccttgaaaat ccaaagggaa cttactttgt aaaagcagac gcaatatcgg ctgacattct 1309621 ttcaatgaat agagtaaaag cagtgaatcc atctgccatg acagaaaaag aagccgagca 1309681 tctcgcgctt gagcgggtgc cgggaacggt caaaaaacaa acacggcaaa gtcaagttgc 1309741 cacttatacc atacaaaaag aagacgggaa aacatacgaa gtgaaggtag acatgcaggc 1309801 aaaaacagtc ttgtctgccg atcaaatcag cagcaaagat caacaaaaaa cgccgattac 1309861 gaaaaaagaa gccaaaacaa ttgcagagcg aaaaacgggc ggaacagcgg atgacgcaga 1309921 tctcgaagaa agtgagggca ctctcatctt tgaagtagac gttgatcttc ctgataataa 1309981 ggaagcgaca gtgaaaatca atgcctacac aggaaaggta gctaacattg tgtatgaaga 1310041 ctgacggttt ctcatcaaat tctcatcttg ctctcgtttt cctttcatgt tgagtatgta 1310101 aactgtactc atacaaaaca aaggagggct cacaaatgct caagaaaaaa tggatggtcg 1310161 gtcttttagc agggtgccta gcggccggag gattcagcta caacgcgttt gccacagaaa 1310221 acaatgaaaa cagacaggct tcttctaaga cggatgcact cactgaacaa gaagcagaag 1310281 caattgctaa aacagttgtt gacggcacag tagaagacat tgacagagac ctttacaacg 1310341 gcaaagaagt ctatgaagtg gagattgaaa aagaaggtga agactacgac gtttatgtag 1310401 atattcatac aaaacaagcg cttaatgacc cgttaaagga gaaagcagaa caagtcgcca 1310461 taaccaaaga agaagctgaa gaaattgctt taaagcaaac aggtggaacc gtaacagaaa 1310521 gtaagcttga cgaagatgac ggtgcttaca tctatgaaat ggaaatccaa acgaagcaag 1310581 gaactgagac agaatttgaa atttccgcaa aagatggacg cattatcaaa caggagatag 1310641 atgactaatc aaaacccccg ctgcagcggg ggtttttcat gataagaaac cttcttttgg 1310701 acaatctaag tagaaaagga ggcgaaacgc atggaaaaga aagaggagca atacatcaat 1310761 caggctgaat atgtccctca tccgacgaag gaaggagagt atgccttatt tcttcatgaa 1310821 acgtatcatt tgctttctga agatgacgag acacaaacaa cagaataagg gcttaggccc 1310881 ttgttttgtt ccgtaattgt gatgtaagcg catttattac ttttttgagt tgacatagct 1310941 tgtttttttc tgtaatctca gtgtgtcaat tcaattagga acttcgttag gtgaggctcc 1311001 tgtatggaga tacgctgctg cccaaaaatg tccaaagacg ccaatgggtc aacagaaatc 1311061 atcgacataa ggtgattttt aatgcagctg gatgcttgtc ctatgccata cagtgctaaa 1311121 gctctacgat tgaaggcgcc cgcacgcttt ttttgccgtg cttctttcac cttcaatccc 1311181 gaaggctttt tttatgcctt taaaacgaaa ccaatcaaag gaggtgcgga gtatggattc 1311241 tccccattcg agtcaatctg aagaagtacc catatactat gacagcaaga caattgatta 1311301 cacgatgagg agacgaactg ccgcaccttc tggcgaggcc ggcacgtctc cgtagaggag 1311361 gtacgagtcc cgatggttca aaacatgacc tatgacgaac tcattttacg catcattatt 1311421 ttactgcgag acgggaaaat cagggatttt agaagtgtta ttgatgagct tcagccctat 1311481 gacatggcat ttatttttaa agaaatgccg gaaaaacatc gcgcccgcta tttatcttat 1311541 ttaactgtag acgatatcac tgatatgatc ggggagctgg aacgcgaatt tcagcttgtc 1311601 gtcttaaata aagtcggaaa aacaaaagca acactggcga tgaacaaaat ggacaacgat 1311661 gacctcgctc aattgcttga agaaatggac gaagaactga aggaacagct tttatccagc 1311721 atggaagcgt cagaatcaaa agctgtacag ctcttgatga attacccggc tgattcagcg 1311781 ggacgcatga tgacaaaccg gtatgtgtgg atccctcagc attacacggt aaaagacgcg 1311841 gtcgtcaaac tgaaaagctt cgctgaaata gctgaatcga tcaactactt atatgttatt 1311901 aatgaaagca aacagctggt tggggttctt tcctaccgcg atttgattct gggtgaacct 1311961 gaagaaaagg tgcaggattt aatgtttacc cgcgtcatat cagcagatgc tcttcaggac 1312021 caggaagaag ttgcccgcct gatagaacgt tacgattttt tggcaatacc ggttgtagaa 1312081 gaaaacaacg tgcttgtcgg cattgtgacg gttgatgata ttatcgacgt tgttattcgg 1312141 gaagctgatg aggattacga aaaatttgcc gcttccggta aagacatcac ctttgacaca 1312201 aaagcttacg tggcggcata ccggcgtctg ccatggctga ttttactctt atttatcgga 1312261 ctgatttcag gaagcattat cagctatttt gaagacgcgc tgaagcaggt tgtcgcgctt 1312321 gcgtttttca tgccgatggt gtcagggatg acaggaaata cgggaacaca atctcttgcg 1312381 gttgtcatca gaggtttgtc taaagaagaa atgaacaaaa aaacgattgt gcgcctgatc 1312441 ttccgggagt tcagaacaag catttttatc ggagcggttt gttctgtgct gattgcgatt 1312501 gtttctatca tatggcaggg gaatgcgctt ttgggatttg ttgtcgcctc ttcactgttc 1312561 ttaaccttaa tcatcggcac gatgtcagga acgattatcc ctattatttt gcacaaactg 1312621 aaagtagacc cggcgattgc ttctggaccg ctgattacaa cgttaaacga tattttatct 1312681 ttattaatct actttggcat tgccactgca ttcattcact cattataaac gtaaaaagtc 1312741 cgtctcaact gcgagccgga cttttattat ttaacggttt ttgtaccgaa agtgagcatt 1312801 aagctgcccc tccagcattt ttttccgcac ttgcggatcg ttttttaaca tctgttcttt 1312861 tttgcgcata tcctttaaaa tctctgccgt ctgtacgccg tcttcacgct tattggcgat 1312921 atccatcagc cgctccacat cggcaaagga gtattttctt gtcccccttg aagaacgctg 1312981 cgggtaaatg agctttcgtt cctcataata cctgatctgt cttacggaca atcctgtcaa 1313041 ttcactcaca attccgattg aaatcacttt tttgtcttta taagaatgat cttctgtggt 1313101 catttttcca cccctggatg tcttttgata atagtatata aaaaacaaag agaaaaaacc 1313161 tgacgcttgt catattttct aacatcaaat agaagatttt tgaaaaaata cggaagaaaa 1313221 attaacaaga ataatgcgta acacccaagc gcgttttatc ctttatgtaa cgaatcaaac 1313281 gaggaggaag gataatcatg gaggaagaaa aagcagtctc actggcaaaa gaaattatag 1313341 agttggatat caagcgtgat gaaatgctgg agacgtttat gcagcttgcc ggagaacagg 1313401 cttttcaatt attaagatcg gttcaaaacg gacaataccg aaaatcttcg taaacataaa 1313461 ttctttacat tagattcata ccacgttcat ttaaaaagag tatcttttgt ataggatacc 1313521 tcaaaatgaa ggaggacgct atgagtaatt tattgaaatc cgctttagaa aaagaacgac 1313581 gccattattc tgaaaaactc tatcagatag gggtttataa taaagaggtc atgaacaaaa 1313641 tgacgatttc tgagcttcgg aaagaatacg cttatttctt tcgaagcatt acaaatcata 1313701 aaaattatcc ttatacaaga taatgtataa ggattttttt gcttttagaa ggaatttctc 1313761 gaattatagc gaatacgtat agtaagggac tgaactctta ttatatgtaa gggttttcat 1313821 tattttttta taaaaatcct atatacgagg tagatatgat gagattatcg tttaacgaag 1313881 aagaagttga gcgtgcgatg aatttgtaca gagtttttgc aagggctttc aaaagtgtgt 1313941 ccgaacatag tatccgtgat agcaaagagc acggttttaa tcccactgaa tttgctgtac 1314001 tggaactcct gtacacaaga ggcccgcaaa aattacagca aattgggtcg agacttctgc 1314061 ttgtaagcgg aaacgtcaca tatgttattg acaaactaga aagaaacggg tttttagtaa 1314121 gggagcagga cccgaaagat aaacgctctg tttacgcaca tttaactgac aagggaaatg 1314181 agtatttgga taaaatttat ccgattcatg cactgcgtat tgcgagagcg ttttcaggtc 1314241 tttcgcctga tgaacaggac cagctgatcg tcctgctcaa gaaagcaggc atacacagcc 1314301 agcatttgct gtttcgttaa ctattctaca ctctctattt caggagagtg tttttttgtt 1314361 tccatatgat tctttttaaa acatctttaa tcttcctatc agacatttcg ccaaggtatc 1314421 cattgacgtg ttttttatac tccttcatct gttcgttcga ttgaaaaaat gccgcgatat 1314481 actcttctgc tttctgcatg tcccagtttc tcatatctgt gacgagtttc ctttcatgta 1314541 gaaggtttaa attcatttcc tcctgtcccg gcagtgcatg ataaataaat accggaagcc 1314601 gtttctgtaa gcattcactg atggtcacgc ctccgggttt agtcatgatg cctgtcgcct 1314661 gttcgtacaa acggttcatc tctgctttgc tgtgaaggta aggaatcgcc tcaatcaagg 1314721 ggtggtgtaa acttttgaca taggagtaga gcttttcgtt tctgccgcat aatattttgt 1314781 ataagatctt tccgcctggc gacagttcct gcacccattt taaaatccca ccgaccccca 1314841 tactgccccc tgtgatgatg atggtatatg gcgggtggtg ctgcaaggta tctgctgatt 1314901 ccatttcaaa attttggtga actggaatgc cggtcaagta tatgttgttc tgatcgatac 1314961 cctctgatat tagctgcttc tttacttccg tgctcggaac aaaatggtaa tcaatgttct 1315021 tccgtcccca taattgattc acgaaaaaat cagtgtatac attcacaacc gtcagattcg 1315081 gatattcagg ctttagtcgg ttcagcagat aagaaggcag cgcatgtgtg cagaaggcga 1315141 tatcaggctg tttttcttgg aggatgtgcc tcatttgctg tgtgaacagc cattcgtaca 1315201 tgaaatagcg tttgtcatgc tgaaattctc cgcaggcgag gagcctgtaa atgccgctgt 1315261 acgttttcgg gaaatattga atccatttta aataagccac ggaggacaat ttttctaacc 1315321 gcctatacga atgtgaaaag atatcaatct tttcagctgc cagcccttga gactctaatt 1315381 cagcctgcaa tgcatcagcc acatgatgat ggccggtgga aatgcttaaa aaaggaaaaa 1315441 tgagaatgtt tttcatgaca gtcctcctaa aaaaatatgg caactatatt ttgaggagaa 1315501 cgttcacaaa atataagggt gtttttgatc ataaggaagg tgaaaagatg aaaacttgtt 1315561 tcctttccat atggagagtg gttgatccga tttatttctt tttttcaagg ctaagcttga 1315621 ttgacaacga tcaaaaaagc gtttttcgag tcaggctgac gaagtacaaa ggacatcatg 1315681 tcgtgcttag cgacggaacg catataagaa aaaatgatgt gctcgttaaa atccacctgc 1315741 ataacataaa gctgatcagg gagctgcaaa gcattgagag cgcagtcaga aagggaatca 1315801 ttatttatca gaaagtatat caatcgatgc cgcttcttct tgactatatc aacaatcata 1315861 aaaaaagcga gaaaatcaaa ggaatcattg ggattacaat gcttgacaaa ggtgtggaaa 1315921 ggctcggctt tgatgtgatc accccggtga acccttttta cagatgcttt aaaaaagtgt 1315981 ctcatgtgcc gattttatat ttgacttcaa agcctgtgag cttgcggcat ttaccgaatt 1316041 catcctattt gtttatctca aaagaaaagc tgcagaaaac ctatcaaaaa aaagactgat 1316101 gcctcggtca gcacagtctt ttttgattaa atctgatgaa atgtcacttc agggcggctt 1316161 ccgacacgga tatttacgcc ggtttgtccc aagccctcgc tgatataaaa tggtttatcg 1316221 tgatgataat gaaggccttt aatcatgttc attcgcacga gctttcccat tttcaccaaa 1316281 tgatacggtt ttggccagtg aatttgcccg ccgtgaaaat gccctgacag caggtaatca 1316341 taatgaacat ctttcatatc cagaataata tttgggtcat gtgttaagac aagatgatag 1316401 ccattttcca gactttgata agagccggtg atattactcc gattcgtact gtaatcatca 1316461 atgccgataa tattgactgg tcctgcagcc gtctcgattc gaacatgttc attttgcagc 1316521 gtgatacagc cgttttcctc taaaactcgc ttcaatctct gaaagtcctc ttctttcaat 1316581 acataatcgt ggttaccgaa caccgcgtac attccatatg caggctttag cttttgcaag 1316641 gcgttcaagt aacctgccag tttcggaata ttacgtttcc gatcaagaaa atccccggta 1316701 agagcaatga tgtccacagg ctgatctttt gttaaatgat acagctcctc aggtgagact 1316761 gaaatgtttt ccaagtgaag atcagataaa tgaaggatat ttaatttttt tctggctgga 1316821 aggccgtctt tttggtcgat tgaaatggtg ttgactttca catcttttgt attgcggttc 1316881 gctttatata gaaatggcac aaatacgagt atggccaatg aaagtaagat tgtaaacaaa 1316941 atatatcccc tcccttctat cagtatagta agtgatcaag ccctatggat agcgggaatt 1317001 aatgggtaga gacaggttga aaaacggatt gtcatatgat gaatgatttg gaagggaaaa 1317061 gggataataa attttgacac atgaggcaga acatgccgac ggagtcagaa taacaaatgg 1317121 atgtgtaagc aatgttacga ttgatgagac aacaaaaaaa agaaacatat tatctctgga 1317181 tcgcattatt tcttctttta ttgtatgtat ccccgctttt tattttaaag gaagatgccc 1317241 atatccgggt ccacgataat ttagattcca acatcgcttg gtacaaggtt ctggccgata 1317301 gcggagaaat cgtcggcaag gttgacgctg ccattccgca aatcattaac gggctgcccc 1317361 gggatgcctt tggcaccgag tggagcggaa ttgtttggct ccatgctttc ttttcttcca 1317421 tgaccgccta tgcaataagc cagacggtta caagagttgt cgcttttttt ggaatgtatg 1317481 tgctgctgaa gaaacatata atcccggaac caaaagcggc tttcatccga attggcgtat 1317541 cgcttgcatt tgccttaaca ccgttctggc cttcgggaat gctgagtacg cttgggtacc 1317601 ctttggcact gtgggctttt ttaaatatcc gaaaagggga tatctcatgg agagagtggc 1317661 tgacgctggg cttgctccct ctatactcaa gctttgttct aggcttcttc tttttcctgg 1317721 cagggatggc gtgtttttgg ctgtatgatg ccattacaaa aagaagatgg aatttgatgt 1317781 tcttaggcag tattgcattt atgacgagta tctatctttt cgttgaatat cggcttgtct 1317841 attcgatgct gtttgagcac gcaccgatgc atcgtatcga atttatctca tctaggcatg 1317901 acgtttggca ttctcttcga ctatccataa aaaactttgt ctatggccat aatcatgtga 1317961 tgaccgttca taccgttgtc atccttccga tcctgatggt cgtatttgct gctctgctgt 1318021 tcaaacgaaa tcggacaaag ccagaaaatg tttatctgtt tttatgtgtg cttaattacg 1318081 ggttgtcatt atggtatgcg ttttggttca acaaaatttg ggctgttcca aagcagaaat 1318141 ttgctttttt agcagaattt aattttgccc gttttcattt tcttcggccg cttgttatat 1318201 acgtgagctt tgcgcttgct ttatatctca tttggcggat ggggaaagga tggaaatggc 1318261 ttgtgtacgc cgcagtcgct gcacagctga tggtgttggc gccttttaat gaagaatata 1318321 cgtatggtgt tcattacaac gcgccgacat tcagggagtt ttatgcatca gagcaattca 1318381 aagagattaa ggaatatatc ggacgtccgc aagattcgta tagggtggcg agcatcggac 1318441 tgcatccgtc tatcgcccaa tataacgggt tttatacgtt agatacgtat aacaatctgt 1318501 atccgctctc atataaatat gaatttagaa aaatcatcga aaaagagctg gaaaaaaatt 1318561 ctcggctgaa acaatacttt gatgaatggg gcagccgctg ctaccttttt gtcgatgaac 1318621 tcggtaaacg atatgatttc aaaaagaact cgaagaaaac gatcaacaac cttcaattaa 1318681 atacagatgt atttaaaaaa atgggtggac ggtacatttt ttcttcagtt ccgatcatga 1318741 atgctgaaca aaaccatctc gcgctcgtaa agacgtttga ccataaagat tccgcctggc 1318801 gcatttattt atatgaaaca agataaggag gatatcgatt gaaacagtca cagccagtat 1318861 taaccatcgt cgtcccgtgt ttcaatgaag aggaagtgtt tcaagaaaca agccatcagc 1318921 tgacagaggt tgtagatgat ttaattgaag aaaaattaat tgctgaagac agtaaaattc 1318981 tgtttgtcga tgatggcagc aaagaccgca cttgggcttt gattgctatg gagagcataa 1319041 gaaacaagaa ggttaccggc ttaaaattag cctgcaatgt cggccaccaa aaagcgcttt 1319101 tagccggatt gcataaagcg aagaataggt cagactgcgt catttcgatc gatgctgatc 1319161 ttcaggacga catctctgtg atccgggatt ttatgctgaa atatcatgag ggctgcgaga 1319221 tcgtttacgg tgtacgccgg agcagaaaaa ccgatacctt tttcaagcgc acgaccgcgt 1319281 tagggtttta tcgtctcatg aataaacttg ggattaaatt aatttataat catgctgatt 1319341 ttcgtttaat gaataaaagg tcccttgaag agcttgagcg ttatccggaa gcgaatctgt 1319401 ttttaagagg tattgtcccc atgatcggct ttaaatcggc cgaagttttg tatgaccgca 1319461 aggaacgctt tgccggcaaa acgaaatatc cgctgaaaaa gatgctatcc ttcgctttta 1319521 acgggattac ttcattcagt gtcgcaccaa ttcgattctt tacgctttta gggtttgttt 1319581 tgtttttcct cagcgctgtg gcagggattg gcgcgtttat tcaaaagctg ctcggccata 1319641 cgaatgcagg ctgggcgtct cttatcatat ccatttggtt tttgggcggg ctgcaattga 1319701 tgggaattgg aatcatcgga gagtatattg gaacgatttt ttctgaagtg aaaagacggc 1319761 cgaaatacgc gattgatatt gatttgtata atgaacagct gagcccgctt cagcgccagg 1319821 aaaaagagcg gttagaaaaa aagtacagtt aaacacggaa agagctgact tcattagtca 1319881 gctctttttc ttcaactgat gcaatatagc gctaagcggt tcgtcttgcg ggttgcggta 1319941 aaaatcaaaa aatgggcagc cctgcttctt aattcgatcg atgaccgtat caattgtaaa 1320001 cagagcgggt gttaaagatg attgcacctc atgccagtag agcggggctg caacagtccc 1320061 aagctcattt cctctcgttg aatagggaca gataatcgtt tttccttctg catgctgcaa 1320121 ataatcaaga tacaatttgc agtgtctgtt tttaatcaag cgttcagtgg taaagagctc 1320181 gggaaatgca ttggtgcagt actctgcgat cagctgcgta aattggcgtg tttcttcata 1320241 cgtaaatgcc tcgggagaca agggaatata aagctggatg cctttgttgc cggacagctt 1320301 cgggtacgat gtgatgccaa aggaatccaa cagccgcttc agttcatttg cggcctgcac 1320361 ggccataaga aagtcatctc gcgaaggcgg gtctaaatca atgacaatct cagccggacg 1320421 cctgctttta atggtttgaa aaggaacgtg aaactccaaa gcaagctggt tgcaaagcca 1320481 tagcaatgta gacatatcct cacagacaat atgttcatgg cttccatcat agaaagactg 1320541 aacaaaatcc ggcgcatagt ccggcttgtt tttttggaaa aatgattcgc tcctagatcc 1320601 atgcggatag cggatgacgg tgacagcccg gtttttcaga aatgggagca ggtagtcact 1320661 gacttcaatc atatactgaa taaaatcttc ttttgttttt ttattctttt caaatatgat 1320721 tttatccagg cttgtgaact ggagctttgg gtgaaccggt ttggagtgtc gtatgacttg 1320781 cgcatacgtg cattcggtcc agtccatttg gaattcgaaa ccgataaacg atacctctct 1320841 taatgtgcct tggagaattg ttaagtattg aacagctgca caaatcgaag gttcaagcgt 1320901 aaattcgcct gagggtgttt gatgtccgtg ctgttccata atctcgcgta tagcgctttt 1320961 ttcctcatca cgcattccgt gcgagacaga ggcaatcggt gtcattattc cgttttttaa 1321021 caccgatacc gtcagaaacc cgttgttagg gttgaaccct gttatgcaaa cataagcttg 1321081 tttaaagttt ttatatttga gccaatcgga cgaccgcttc ttttcaagcc atttgctgtt 1321141 tgttttcttc gctacaattc cttctccgtc atattttatt accatctccc agagttgatc 1321201 aaaatgatca taacagggaa tggattgaat ggtttctttt gcgtaaggat ctggagatgc 1321261 aggaagcttt gctgcggata tgagttcacg cagcgatttt ttgcggtcca aatacgaaag 1321321 aagcgttaca tcttctccgc ttcgctctaa caaatcaaag gcgagaaagc agcacggccg 1321381 cgcgtttgcc gattcctgaa tcttgtctgg ccttttcaaa cgcccccgca cttgaaggtg 1321441 ttcaaaatct gcacgacagg gattcaccaa acatacgatt tcaccgtcaa gtgtcagcgg 1321501 aagctctttt tctaggtgct gaaaggcagt tttggcgaat tgtgtgattt cagggaaggt 1321561 gctgctgagc tccacaccat ttctgctggt taaggtcaca cctgaagaat ggatgcggag 1321621 aatacagcgg tacccatcat attttacttc gtaacgccat tctgctccga ttggcggtga 1321681 cgaagttaag accggctgca tggtaaacgc catgcgctat gatgtgccgg aggctttttt 1321741 tctagttgtt ttttgttttt tatctccggc tcctttcggt tcagcggctt gtgcaggtgc 1321801 ggcagccggt gtctcccggt tcggccttct ggttctgtcg atgctggctt gcagagcgct 1321861 taccaggtca atgacatctt cacgaggtgg cgctttatca ggagtgacag ccgtttcttt 1321921 attttctagc ttgtcgttga ctctttgcag cagcgcctgt cggtacgtgt cttcatattt 1321981 ctcaggctca aacttagcag tcagttcatc tattaatgtg atagcagttt gcagttcctt 1322041 atcgtttaca ttcgattgat caggtacacc tgggacttga gcggcgcttc tgacctcatc 1322101 gggataatgg atagactcca tgacgataca attttcataa acgcggagaa tcgccagctg 1322161 ctgctttgac ctgattgtca tattggcgat accgatcttt ccggttgagc gcagcgcctc 1322221 acgcagcagg gtataggcct tcgtcccatt atccccgggg ccgacaaagt aggagcggtt 1322281 aaaataaatc ggatcaattt cctgaagctg aacaaagtca acaatctcaa ctgctttctc 1322341 ctcatgctcc tgttttaagc tttttaaatc ttcgtctgtc agcactacat attttccttt 1322401 tacatattca tatcccttca caatttcatc aggactaaga gttttttcgc aatttgtgca 1322461 aactttctcg tatttgattg gtgcgtgatc ctctttatgg aggctgcgca gtttaatatc 1322521 tttatcttct gtggccgcat atagcttgat ggggatgttt actaatccga agctgatcga 1322581 tcccttccac attgtatgca tatcgataaa cccctttttt tctttagtgt gaagagaagg 1322641 agtacgattc atgtgtagta acttatgggt gaaaaaaagc cggcgctgtt attgcgacgg 1322701 ctgttcaata atgaattgtt cgaattgttc cggaggtatt ggcctgctga aaaagaagcc 1322761 ctgcaaatgg tcgcagcctt tttcaaaaag aagctgcttt tgagctgcat tttccacacc 1322821 ttcggcaatc acctgcaaag acagctgatg ccccatggca ataatagctc cggtaatttg 1322881 ctctgattta ggatgggtct gaatatcgtc aataaatgat ttgtcaatct tcagcctgtg 1322941 aatcgggaag tccttcaaat agctaagaga gctgtgacca gtaccgaaat cgtcaatact 1323001 gattctgatt cctaattctg ttagggatga caaaaccttt ttggagtgat tgagattgtc 1323061 cattgtcatg ctttccgtca cctccacttc aagaagctgc ggaggaagct ggtacttatt 1323121 aagcgtatcc ttgatgaggg gaatcagatc tttagattga aactgtctgg cggaaatatt 1323181 aatggcgaca gaaagatcat agcctttgtc atgccaaatc cttgcctgct tgcatgcttc 1323241 atctataatc cactttccga tatcaataat aagtcccgtt tcttctgcaa caccgatgaa 1323301 ttctccgggc ggacgcagtt gcccgtctgg tgtcacaagg cgtatcagtg cttctgctcc 1323361 tgtcattttt tgttttttca cactgaattg cggctgataa tgcaagacaa atctatcgtt 1323421 ttcgattgct tctctgagta ccatctcttg gttaagctta acggtttctt tgttgccgat 1323481 tgaaaaagaa tagtatctgt atttgctttt gtttcgttct ttagccgcat acatcgccat 1323541 atcagccttt ttcatcaatt caaggccatc cgtcccgtct tttggagata tcgcaatccc 1323601 gatactgaca gatgtgacaa gggtgtgatc ttgaattttg aaaggttttt tgaatttttg 1323661 gataattttt cttgctaaaa catctgcttc gcctgttcct gtattggcgt ctgttaatat 1323721 aataataaat tcatcaccgc caagacgggc gataaatccg ttatcaggga ctacagatga 1323781 caggcgttta gctgcaaact gaagcaattg atcaccgaca ttatgcccta atgcatcgtt 1323841 aatcacttta aaccggttta agtcaagaaa gaatacaaca gtgttataat gcaaggaatg 1323901 ctcgcgattc agcacctttg ttagatgaga gatggcatgc cttctgttag gtaagtctgt 1323961 aagcgaatca taatgagcca ttctatggat ttctttttct gctttgtact gcttcgtcat 1324021 gtctttacaa atgacataaa tgctgtctag ttcctgattg acctcaacag gtataagcgt 1324081 aatatttaag tgaaactggc ctttttcagt gataagatcg ctatcgctgt tcatcgcttg 1324141 tttatctttt ttaacttgct caaaaaggcg cttaaccttc agtgatgtgt aattcctcca 1324201 gtcatgcatg ctgaagccaa atttgctgat catttcctca ccagcgtgat tggaagatat 1324261 tatgtctcct tctaatgata aaataaaaat tgcatcaata ttgtggacga ttaaagactg 1324321 aaatcgctgt tcgttatcct ttatgcgttc gctctgttta ataaactttc gatctgcatg 1324381 ggaactgaat aacaataacg tttggataca aaaaataatt aaagtaacaa aaattgacca 1324441 atgaaacgtt tgcacctcca tatggcttcc gggcggagcc atgtccttat ggaaagttgc 1324501 cgcaagcatc cctgtgtagt gcatgcccga aatcccaatg cccattacaa ttgaactgac 1324561 gcctttatag aatataagat gctcagaatg tttttttacg gccaagtcaa agaatatttt 1324621 taacgagacg aaagaggctg caatcgcaat gataattgaa actgtaaata aaataggttc 1324681 gtaaataatc attacccggg aaatggcaga cattccgata tagtgcatag aagcaataga 1324741 tgcgccaagc acaactgatc cggtaagcag tctgtaatat gtaagaatgt gccggctgac 1324801 aaaatataat gacacaaatg atcccgaaac agatgcgcca atggctgcca ttaaaggcat 1324861 gaattcatat tccatcggca tttccatatg gacggccatc atccctacaa aatgcattga 1324921 ccaaataccg aatcccataa taagtgagcc gccgatcagc caaattttac tttttaagcc 1324981 tgtattgatg gtgactttcc ttgaaagttc aagggaaata tacgaggcgg tacaggcaat 1325041 tagaatagat aaacatatga gagtcgtatt atatgtaacg tgtatttcca aatggagatt 1325101 ccccccgtat cgtgtgttcc agtcttgttg actctcttta ttatcggctg cttaaccgca 1325161 gagtttcagc cttcaaaacg atagaaatac gagggagatc tatttttagt tcaactgacc 1325221 gtgaaaaatg tgttaaaatc atcttgatgt tttccgaaaa gagaaaaatg tatgatacat 1325281 aaacatgaaa caagggagtt ggtggctatc gaagagctgg ttatgtcatg gattgaagca 1325341 tttaaaagct tatcttattt tggaatattt ctagcgctca gcattgagtt tattccggcc 1325401 gaagtcgtct tgccgcttgc gggctattgg gtatctaaag gcgatatgac acttgctggc 1325461 gttgttttgg caggatcgct tggaggagtg gccggtccgc ttacgctgta ttggataggc 1325521 cggtacggag gaaggccgtt tcttgaacgt tttgggaagt atctctttat taaacctgaa 1325581 gcgcttgata agtcagataa ttttttcaaa aaacatgggg gctttgtcgc cttcagcggc 1325641 cgtttcttgc ctggtatcag gacattgatt tccataccgt gcggaattgc aaaaatgaat 1325701 gtttgggtgt tttcgcttta tacattcatt gctatgcttc cgattacatt tgtatatgtt 1325761 tatctcggtg tgaagctcgg tgaaaattgg aaggcagtcg gctctattct tgatcaatat 1325821 atgcttccga tcgggatagc gattttggcg ctgttcctgc tctacttact gatgaaaaag 1325881 aggaagaaac gcacgcactc cgaacaatta tctgtatttt tgaaaaataa acgttgacaa 1325941 atcactgcgc tgcgcatatt attgacgtat aaaatcatat ttcttgaaat cccaaagggg 1326001 agtagcgtcc ggaatgtatt ccggaaacaa agtcgtcatt tcatggattg tatccatcgg 1326061 ctttgttggc atgcctgaat tcatgtctag caagaccttt gccttatgtc ggcaaaggtc 1326121 ttttttgcat ggtccggccg gcataagatc ggatgaagag aaagaaaaca acttttttgg 1326181 gagggtatca tttatggatg cagcattatt attagagtat ggttgggttc ttctcgtctt 1326241 gatcgggctg gaagggattt tagccgccga taacgcgctg gttatggcgg taatggtaaa 1326301 acatttgccg gaggaaaaaa gaaaaaaagc gttattttat ggattggcag gggcttttgt 1326361 tctgcgattt ggctctttat ttgcaatttc tttcttggtc aacgtatggc aggttcaagc 1326421 gattggcgcg atctatttgc tgtatatctc agcaagccac ttattgaaaa gatatgtatt 1326481 taagaaagaa gacacacata aagagacgaa gcaaagcggt ttttggccga ctgttttaaa 1326541 agttgaactg gcagatatcg cgtttgctgt tgattccatc ttagcagcag tagcgctggc 1326601 ggttacactt cctgggacat cactcccgaa gatcggcgga cttgacggag gacaatttct 1326661 cgtcattttg gccggcggta tcatcggact ggtgatcatg cggtttgcgg cttccatgtt 1326721 tgtgaagtta ttaaaggaac gtccaagcct agaaacagca gcctttgtga ttgtcggctg 1326781 ggtcggagtg aagcttgctt tatatacgct tgcccatcgc gacatagcgg ttgtttctga 1326841 gcactttatc cattctggaa catggaagct gatattctgg ggtgtcttag cagcaatcgc 1326901 ggtttgcggc tggtttatgt caggtgggaa aaaacagccg gagggtgcac aaaacgaaca 1326961 aaaaaacagc acccgtgaac gggcgtaatc tgaaagactc tgcttaaaag cagagtcttt 1327021 ttgtgtttga agcgttttca taagcgaaat aaaataacat ttttataaca tctttgttac 1327081 aaaaaacacg cataaaaccc ccttaattct ttagaaaggc acgaaatcat gtatagaacg 1327141 tcagaatggt ttgtcataat tgagacattg gaaatcaata tttctttttc tcctttgcga 1327201 atccctatca aattagctat cattaatgag tagttatagg gaggaactga ggtgaaacca 1327261 gtgcttagcc ttttgtttaa attgggaaaa aagaagcaaa cacttgaaaa agctgttgag 1327321 agtatacaaa aaggcaataa agatctgcaa aatgaattaa tacagcaata taagccattt 1327381 atcgcaaaga cggtttcatc cgtttgtaaa cgatatatag atgaaaaaga cgatgagttc 1327441 agtattggac tgatcgcgtt taatgaagct atagaaaaat attcacctga aaaaggaaat 1327501 tctctgctcg catttgctga gcttattata aaaagaaaag tcattgatta cattagaaaa 1327561 gaagccagaa gcgcacaaaa tataaatatc gatttacagg aaggagacga tcaggagtca 1327621 tcacaaagcc tgattgaagc cgagctttcc attgatgaat accgccgtca gattgaacag 1327681 gagcagaggc gggaggaaat cctctatttt caaaagcagc tcaaggatta tggtttatcg 1327741 tttaaagaac tgcttgaaaa ttctccaaaa cacacggatg caaggcaaaa cgccataaag 1327801 gtggcaatga cgcttgttga acatgaagaa ttggccgcta tcctgtatac aaagaagcag 1327861 cttccggtca aacagcttga acagcttgtc tctgtaagcc gaaaaacgat tgagagaaac 1327921 agaaaatata ttattgcgat gtgtattatc attacgggtg attatattta tttaaaagat 1327981 tatcttaaag gggtgctgca ctcatgagaa gagggattat agtagagaaa aataaaaaat 1328041 tcgtcacgtt gctgacccct gacggacaat ttttaaaagc caaaaatgat cgacacagct 1328101 atgaaatcgg agaagaaatc atgcttccga gtgaaacacg catgggcaga agggccagct 1328161 tttttgattt ttttaaactg cgccctttca aaatggggat ttttacgatg actgctatta 1328221 tgctctttat ttttatagtt ctccccgttt tttctaataa taaggcctat gcgtatatga 1328281 caatcgatat caatccaagc gtcgaaatgg cgttaaacag cgattatgaa gtgattgaac 1328341 tgacgcctct aaacgatgag ggacagaaag tcgtgaatga tatagatgat tgggagaaga 1328401 ctgattttaa aaaggtgatt gacgatatta taaccgactg cagtgaacac gggtatgtaa 1328461 aaaaatcgaa agaaatattg atttccactg tttatgaaaa cacagaagac aatacatata 1328521 aaaaggctgt gaaaaaacag ctgaatgatg tgactgaaaa atataaaacg acataccgca 1328581 tggaatctct cgagtcagat atgcaaacga gggaaaaagc gaagaaagaa ggcgtctcaa 1328641 caggcagcta catcaaatca aatgaaaaga atgacaataa agatataaaa gatgactcca 1328701 gcaaaccatc cggggaagag gatcaaaaga gtgatgaaaa tgaggatgaa aacaccgatc 1328761 aaactgacac ccaggacagc aagcaaggag ataatgaaca gctgaatgat gcggattccg 1328821 gagaccagaa agaagagaaa gcggatgacc agattgatga tagtgacaaa gataaaaaaa 1328881 taaaggaatc agatgaaaac acaaataccg aaaaagatgg ggaccatgag caaaccccaa 1328941 tacaagatcc tcaagataaa ggaaatgaaa ataacggcgc tgacaagggc caaagccaat 1329001 atcacaggga ctggaacaat ggtgaacaag gcaagaaccg ttcttcgtcc agaagggata 1329061 acgcttcaga ccgacgtaat ccaaacggct acagcagtga taatcattca gctaaaaatg 1329121 aagattcgcc gagtgccccc ggcgaataaa gacctgaatt tatttagttg tgccatttaa 1329181 ttgtgattgt gcttgctgta ccagccgctt tgtcatttct ccgcctacag agccgttagc 1329241 gcgtgcgact gtatcagaac caaggttcac accgaattct tgagccactt cgagtttaaa 1329301 ttggtctagt gcctgctcca cccctggaac aacgagttta tttctgctcg ccatcttttt 1329361 catctccttt ttcgataaag aaattcttaa cgcgtattta gtttgaaata tacggggttt 1329421 atttatgctg gcaattgttg tggagaaaaa taaaaccccg gcctctgagc cggggtggcg 1329481 cagactatag aatgtctgct gtcattttat gtgcggttgc ctgaatatgg aatgtcaaaa 1329541 tggagaggac tgtaatggcg ataatctgtc tgattttaag ccattggctg tcattcagtt 1329601 cttcaaaacg gtgacggaga cgctctgtct cctgttcggc gatctcctgc agatttgatt 1329661 ctttcataga aggagtatct tggtgatgga tggcatcaag cacatatgcg cagctttcat 1329721 aataagcaat cgggctgatg acatcatcag atctgtctga gattgtgtta aaggccactt 1329781 ttaaaatagc ccgtatgtgt tcaaagtcat aaatggattt taaatcacgt acaattaaaa 1329841 gaataactgc ctgttcaatt gagtattttt tgcccagctc agggtgtccg atcagatctt 1329901 tgatatcacg ctttacccag ttttgaatcg cggttgactt taacgaagtc agctcgcata 1329961 agttgccaag ctctacgatt tcatttgtag acagaccgta ttcttttttc tgtttttttc 1330021 gttcgtatct tgtaagaaat tcaggaattt ctagatgatt ggctgctttt tctgctgaca 1330081 tgttcgctga ttggacgaga atgtcgagcg ggctatgttc tccttgtcct tttagggaat 1330141 agagcagccg caccatatcg gttcgagaga gtttaaaaat gttcattgtt cacctcttta 1330201 aacaatttga cgcggatata ggtctatgta taagttcaaa attcaagcgt cagcaaatta 1330261 cattaacatc atacgtcgaa ttccttgcat tttcaaatgg atgttttata atttaaatat 1330321 acgggttctt ttgaacttaa aataacggag gttgttatgg cgaaaagaat ttttctgttt 1330381 attctaacga atattttggt gcttacaaca atcgggatcg ttttgtctgt tttaagctct 1330441 gttacaggag tcgggacgta ctttacagct gatggcggta tcgatccaat ggcgcttctt 1330501 gtgttcagtt tagtcgttgg atttgtcggt tcctttacgt ctcttgcgat atccagatgg 1330561 atggcaaaga cgatgatggg cgtcagagtg ctgaatccga aaaaacactc gctcagctat 1330621 gaggaacagc aattggttga tcgtgttcac agattaagcc gctctgccgg tttaacgaaa 1330681 atgccggaag tcgggattta ccgttcacct gaagtaaacg cgtttgcgac tggaccgtca 1330741 aaacgccgtt cacttgtcgc agtatcgtca gggctgctgg agcagatgga tgacgcagca 1330801 gttgaaggtg tgcttgccca cgaggtcgcg catatcacaa atggtgatat ggtaacaatg 1330861 acgcttttac aaggtatcgt taataccttt gtcgtctttt tatcgcgtat cgccgcttgg 1330921 atagcaagcc gttttgtcaa agaagatcta gcgccgatcg ttcattttat tgcaatgatt 1330981 atttttcaga ttgtcttttc gatacttggc agcctggttg tgtttgcgta ttcacgccat 1331041 cgtgaattcc atgctgacag gggaggagcg gatcttgccg gcaaggacaa gatgattcat 1331101 gcgctgcgga cgcttaaaag ctattcttcc cggattttgg aagacgatca gacagctgtc 1331161 caaacgttaa agattaatgg caagaagcgc tcttcacttt tctctactca tcctgattta 1331221 gatgagcgaa tcagacggct ggaagctaaa taatacaaac acattgttcc tctgagagaa 1331281 ttctcagagg ttttttattt tatccattga ctaaaatcat aaaaaaataa gcaagttaag 1331341 aaaatgtttc gtaaaagcct ttaaaaatgg acctaatatc tttagaataa ttaccgtact 1331401 taaaaagaga ggcagaagga ttttacatga gattaaagtt tggaaaattg atacaggcct 1331461 tgtcaccggc ccagctgatc gcattatatt attttcttgc agttactgtg gccgttatat 1331521 tgctgagttt gccggcggcc cataaaccgg gggcggattg gacgtttatt gatgcgcttt 1331581 ttacagctgt cagttcagtc agtgtaacgg ggctgacagt tgttgataca gctgatacat 1331641 tcagcacaat agggattttt atattagcat ttgttctgca atttggcgga atcggaatta 1331701 tgacgctcgg aacgttcatt tggctgatca tgggaaaacg aatcgggctg aaagaacgga 1331761 agctgattat ggttgatcaa aaccaatccc agttttcagg aattgtcaat ctgatgaagc 1331821 aggtactgtt tctgatcttg tggattgaat tttttggcgg gctgatactc ggcacatatt 1331881 tcttaaccta ctatgactcc tatcaggaag cctatttaca cggatttttt gccagtatca 1331941 gtgcaacgac aaacggcgga tttgatatta ccggtaattc gatgattcca tttcgccacg 1332001 attactttgt gcagtttatt acaatgcttt taattatatt tggagcgatt ggatttcccg 1332061 tgcttgttga agtaaaggat ttcctgtttt caaagcatcg gcgttatcca tttacgcttt 1332121 ttacaaagat cacgacgatt acgttcggct cacttgtctt gtttggagcc attggcatct 1332181 ttgccctgga agcaaaccat gcgttcgcag gaaaatcatg gcatgatatt ttgtttttgt 1332241 ccctgtttca atcaacggca acccgaagcg gggggctggc aacaatcgat atcagccaat 1332301 tatcagattc cacactcttt tttatttgtg cgctgatgtt tattggagcg tcgccaagct 1332361 cagtcggggg aggcataagg acaacgactt ttgctttgaa ccttcttgcg ctgtttcatt 1332421 ttgcccgcgg caataaggcc gtaaaggtat tcaaacggga gcttcaccct gctgacttga 1332481 tgaagtcgct tgttgtcacg atgatggcga tcctgctcgt ttttggcgcg acactcattc 1332541 tgaccattac agaaaaacat tccctgctgg agcttttgtt tgaagtgtgc tcggcattcg 1332601 gtacaaccgg cctatcgctt ggaattacgg cagatttgag cagtgttgga aaatgcgtca 1332661 ttatgattgt catgtttatc gggcgaatcg gcatcttgac cttcctgtat ctgatcggaa 1332721 gaaaggaaat tgaagcgaat tatcactatc cgaaggaaag agtgattatc ggataggcaa 1332781 aacaccgcat attttgcggt gttttttgat taccaaaaaa aagatgtgtg cctcctgttc 1332841 agttggagaa cctaactccg acaggtgcaa tttacgctcc tgcatcttaa aatgtctgaa 1332901 aattggcgag gaggattcgt atgaagcgta aagctgaagt gaatgaagcc attaaaaata 1332961 acaatacacc taccgagagc atggacccca attcatataa gacacaatat catgacgacc 1333021 ccaattttag aggggcaaac cgcaattcca aacagggcca gcagggaggc atgtaattgt 1333081 gaagaaaaac cgtcatagca gagacatgca aaatcataaa aagcctatga ataaaaaggt 1333141 gctggaggaa gaattctcaa gtgaactcgg ggattacaat gccggaaaga tcatcgaaac 1333201 gctggaagtc accaagcctg aaaagaaaaa agaaaaaaac aaaaaacaac aataaaaaag 1333261 acctcttagg cggcgtcccg cttaagaggt gctttttcta ttttaaataa gcatttttgc 1333321 ccgttcctct gacaaattgc aataagcttg tcatcctcag ctcaatgaat ggctgagcga 1333381 ctgtcttaac aaagttgctg gagaggactg atgtcagggc tgctgttaaa agcaagagga 1333441 tcactaagct ttgatagtca gtaagccaat cctcaagccc gacctgccgt aatgtcttaa 1333501 taataaaccc gtgaagcaga tacacgtaaa atgtccgggt tccccatttg gtaaagaaat 1333561 accgtttttg cggaacgagc gctaaaaagc tgaaggttgc cccaaaggcg agtacatacc 1333621 agccgattcg ggatagtccg cttaccaggg taacgtctcc aaatgaagaa tacggttttg 1333681 aaccaaacag aaaagaatag tcaaaatcga tgccccagca gatgacgaat actgcggcaa 1333741 gcactccgag cgcaatttgt ttgccgcgtt ttgatctcaa taaatcaaaa tgatgtttat 1333801 ttaaataaaa accgacaagg aacatcggta agaatacgaa tgtccgtgac aagctcagcg 1333861 tgctgctgac aaagtccaga taaccgatca gcacggcgat tccgcagctg acaaacagcg 1333921 cccactgctt tgaaagcttt gaaaaaggat ataggagcag gttccaaaag aataagctta 1333981 caagaaacca taacgaccat tgcggatcaa tcgggttcac atttgccatg ctttcatctt 1334041 gcataatgta ataaaagacg gaataaataa tttggaaaat caaatacgga ataatcagct 1334101 tgaccgccag cttttttaca tatcccgccc gtttaaagcc tttcgcgaaa taaccggata 1334161 caagaataaa tgcaggcata tggaatgtgt aaatgaactt gtagaggtag agcataaaat 1334221 gattatcatt aataaaggaa cgaaggatat gaccgaatac aacaaggaat atcaataaaa 1334281 attttgcgtt atcgaaataa ctgtcccgcg atttactcat agcatcacct tctctttcat 1334341 cagtcactaa gagattattc cctgctggta catattttaa aataaaagat gaaaaaggaa 1334401 tctaaaaaaa tgctgattgt taggtcgatg taaagtgacg gtaaggatcg tagaaaatgt 1334461 cttcgtaatg taatgacgct gaaattttct gaaatttata gggcaaatga aggaagttcc 1334521 cgcattttgt agaaatattg agggataggt tttgaagaag gagtgtacat gcatggaaac 1334581 tcttggtgtc cagacaaact cggagctgcg agaggaactg aatcgcctca aagaagaaaa 1334641 cgcgcgactg aaaaaggaat tgaatcagca tcaagtgatt gtcaacaata cgctcgatgc 1334701 tatttttatt tgtgataacg aaatgcggat tgttcaggca aatgaagcaa cagaaaggat 1334761 gcttcaagtt gactcggaag atttgaaaaa gcgttctgtt ttggattttt tgttttcaat 1334821 cccaaaggat gaactgaatc tttccgtaaa gaagtttttt aaaaaaggct ttctgtggaa 1334881 ggaggttccg atcaggcttg attgcggggc aacaaaatac atagagtttc tggccaaaag 1334941 aggtattggt gaggatttct tttttgttgt catgagggac atatcttcta agaagattct 1335001 ggagcgggaa ttctctatga atgaacagct ttttaaggac ttgtttgaca gagcagttga 1335061 cggaatcgtc ctgtttgata aagatggcgg ttttattgat gcaaatttgt ccttttgtaa 1335121 aagctttgaa atcaatcata atgagctgtc tcatttatct ttgtatgagt tcatagacag 1335181 cggctcacga aaagatttcg acaatatctg gaaggcgctc aaccgcaagg gaaaagcgaa 1335241 gggggagctg cctgtcaagc ttcgttcagg agttcaaaaa ctatttgaat tcacgattac 1335301 atcaaacatc atcagcggtt tttatatgtc cattatgagg gatatcacag agaagcggtc 1335361 tatggagctg cagctcttta aaagtgagga gcgcttcaga gaaatctttg aaaatgcaat 1335421 ggacgccatc atcatctggt cgaatgacgg aagaatcgta aaagcgaatc aatcagcctg 1335481 taaaattttt gagctgccga tgaatttgct gttgaaaaga aagctgtgtg attttctcgt 1335541 tgactcgcag cagaaataca gcataacgaa gaggaaatac gcaaaatacg gagagatcag 1335601 agaagagctg ctgtttcaaa tggggaacgg ccaattcaaa gagcttgaat ttacttcaaa 1335661 acggacaatc cttgaaaatc agcatttgac gatcttaaga aatgtaagcg acagaaagcg 1335721 gatggaaaag gagcttcggg aaagcgagct gaaattcaga aaagtgttca acggatcaat 1335781 ggacggcaat gtattgttcg acaatcaata caggatcatc gacgccaacc cgttagcaag 1335841 ccatattttg ggcctgtcac atgaagagat caaacagcac agcctgttag atattatttc 1335901 tgcttatgaa atagaaaatt tggcatcacc ggcaaggcag attaattttg atgaaatgga 1335961 caacgaaatt ccatttttgc tgagcagcgg tgataacaga aaactcgaat tctcatttaa 1336021 acggaatatt attcaaaata tgaacttggc tatctttaaa gacgtaacag agcgaaaaga 1336081 attggaggag cgcctgcgca aatcagatac ccttcatgtt gtcggcgaac tcgcagccgg 1336141 tattgctcat gaaatcagaa atccgatgac tgctcttaaa ggcttcattc agcttctgaa 1336201 agggagtgtc gagggagact acgcccttta cttcaacgtg atcacctcag aactaaagcg 1336261 catcgaatcc atcatcaccg aattcttgat tttagccaag ccccaggcca ttatgtatga 1336321 ggaaaaacat gttacccaaa ttatgaggga cacgatagac cttctaaatg cgcaagccaa 1336381 tctcagcaat gtacaaatgc aacttgattt aattgacgac attcccccga tttactgtga 1336441 accgaatcag ctgaaacagg tttttatcaa tatattaaaa aacgccatcg aagtgatgcc 1336501 tgacggcgga aatatttttg taacgataaa ggcattggat caagatcatg ttctaatctc 1336561 cttaaaagac gagggaatcg gaatgacaga agataaatta aagcgacttg gtgaaccgtt 1336621 ttatacgaca aaggaacggg gaactggact tgggcttatg gtaagctata aaattattga 1336681 agaacatcaa ggcgagatta tggtagaaag tgaagaaggg aagggcaccg ttttccatat 1336741 tacgcttcct gtcagacaga atgctgaaga aagaaggaat gatgaatgaa ctactatacg 1336801 acagccgaaa cgccgctcgg tgaacttatc attgccgaag aggaggaccg gatcactcgt 1336861 ctatttctca gtcaggaaga ttgggtggat tggaaagaaa cggttcagaa tactgagcat 1336921 aaggaaacac ctaatcttgc agaagcgaaa caacagcttc aagaatattt cgcaggcgaa 1336981 aggaagacat tctccctgcc gctcagccaa aagggcactc cttttcagca aaaagtgtgg 1337041 caagcgctgg agaggattcc atatggcgaa tcccgaagct atgcggatat tgccgctgct 1337101 gtcggcagtc cgaaagcggt gcgcgctgtc gggcaggcta ataaacgtaa cgacctgccg 1337161 atttttgtcc cgtgccacag agtgatcggc aaaaacagtg cgttaacagg atacgccgga 1337221 agcaaaacgg agatcaaagc atttttgcta aacatcgagc gaatctccta taaagaaaaa 1337281 taaaacatat ggcacgttcc cttttttcac ggccgacata tcattttatt aagttaaaaa 1337341 agttggtctg atgaaaaagg aggacaaagc aattgaagcc gagccgctct gagaaacttg 1337401 ccgtttttgc cgaactgttt gtgaaactgc atatcttatc aagcgctcaa aaagatgaaa 1337461 tcatcaatgt taacaaaaag aaacaaaaaa accgctgact cggctccaaa tgagcaaagt 1337521 ccagcggttt tttaatgcac cttttctcct ttaaacagct gttcaatctc ttcttcatag 1337581 tttccggtca taatcccttt ttctgtgatg attcctgaaa tgagatcatg aggtgtaatg 1337641 tcgaaagcgg gattaaagac aggcacattg gatggagcgg tccgaactcc ggaaatctgc 1337701 ctgacttcct cgggatctcg ttcctctatc gggatatcag cgccgcattt gacctttgta 1337761 tcaaatgtag ataaaggtgc ggcgacaaaa aacggaatat caaaggcgtt tgctaaaata 1337821 gcaagaccgt atgtgccgat tttatttgcc gtatcaccgt tctttgcaat tcggtcggct 1337881 ccgacgataa cagcggaaat ttgtttttcc ttcatcgtat gggcggccat gctgtctgtg 1337941 atcagagtga catcaatgcc cccctgcatc agctcccaag cagtaaggcg tgaaccttgc 1338001 aggacaggcc ttgtttcaca ggcataaatg tgtaatccca aatctttttg tttggccaag 1338061 taaaacggag ctagcgccgt tccatagcgg cttgtcgcga ttgagccggc attgcagatc 1338121 gtcatgatcc tgtcgccttt tttgaaaagc tgcagggcgt tttggccgat caaccggcac 1338181 gtttcctcat cctcgacctg aatctgaatg gcttcatgga caaggtttgt ttttgcttca 1338241 tttacggaaa tcgcgttttc gaccgaatga ctcagtctct caagcgccca tgacaaatta 1338301 atggcggtag gccgtgagct gtttaaatat tgtttgatgt cttccagtct gcggcggaat 1338361 tccgtgacat tgtctgtttc aatgtctttg gcagcaagcg ccagtccgaa ggcagctgta 1338421 atgccgatcg ccggagcgcc ccttactttg agcgtgacaa tcgcatcaaa tacatcctct 1338481 ttcgtcgtca gctccaaata ttccgtctca tcaggaagct tttgctgatt taaaatggta 1338541 atagctgttt ctttccattc aacagaacgt ggaacagcaa atgaatgggt catgaataga 1338601 tcattccttt acaagtaact taaataattc aataacatct gttatcgttt tgaattccga 1338661 acgtttttcg ataaaggctg tgccggtttc gagcgccaag cgttttctgc cgattcgttt 1338721 atcaaacggc acgatcgtat ccaggtcagc tacatgggca aggccgatcg tgcgtcgtat 1338781 cagctcacag cccgcaaatc cgattgcttc ttcaaaaata tggctgagcg tatcagtgag 1338841 gtaaccgtcg atgttggcgt aaacatccag actgtccttc tgccaggctt cactaaacgt 1338901 ctcttcaaac gtttcccaga cctggttgac atgttcatat aacggctctc tgtcagcccc 1338961 gtcacggctg agtgcgttca aaaataagtt ggcgataaat tgccctacat caaagccgat 1339021 cggtccgtaa aaagcaaact caggatcaat cacctttgtt tcgtgctcac ttgcgaaaat 1339081 gcttcctgta tgcaaatcac catgaatcaa cgtttctgca gacgttaaaa atgacttttt 1339141 cagcttagcg gcttcgattt taacgctgtc attattccaa agcttttcga caaaaggacg 1339201 aagctcttct tcaaaatcat ttgtgtcatg gtcgaagaaa ggatctgtaa aaacaagtct 1339261 ttccgtaatg tcgcatagct ctggatttgt aaactgttta acaagctgtt ttttcacctt 1339321 aggttcaagc gcgtaatctg atgagtagaa aagtgttttt cctaaaaatt caccgatgtg 1339381 ctgcgacaga tgaggatagt tttcaccctc aatgagtcct tttcttgcga tcttgaggtg 1339441 agagagatcc tccatgacgg taaccgccat ttccgtatca gaataaaaca ctcttggaac 1339501 caggtgaggc acatgctcgc cctgacggat gagagcgctg ctttcgattc ttgcacggtc 1339561 gattgtcagc ggccagcttt ctcccaccac ttttgcatac ggaaccgcct gtttaatgat 1339621 caatgctctg tcatgttctt gatcataaat atgaaaaacg taatttaagt tgccgtctcc 1339681 gatctcctgg catgtcagcg tgcttttgct tggaaatagg ccaagcttca ccgccaacgc 1339741 cacagcggag ctttcattta acgtttcgta taaaggtgtt tttgtgactc ccatcatcat 1339801 aacctccaat tatgtaatta attaatatgt ggccgtaaaa aagcctcctt ctcagagaga 1339861 aggaggctta acatctatgt ccgcctctct tatctctcag atcagatctg aatggaatta 1339921 gcaccgtgcc ttaagagacc agcgtctcgg cgcgaaaaaa atgcgcccca tttcacaatg 1339981 gaattacggt cggttgcttt tggggtcaaa aggccaaatc cctcgcccaa ctctcgataa 1340041 gagaatatat tcacttgttt gacaattcta atttatcagt tgatgaacat ggtaacaggt 1340101 aatttagtta gttgtcaata tattttttaa tataaatctt ttctgatatc atcgaaaaca 1340161 ggaatgctct cccgaacttc tgcgctttct tgaaggtcga tttccgctcg gactatgcct 1340221 tcttcccggc cgccttcagc aagtacacgt ccccatggat caataatcag gctatgtcct 1340281 gcaaattcat tatccggatt tgaaccggta caattgcagg ctgcgacaaa gcattggttt 1340341 tcaatggccc gcgcaataag caggcttttc caatgatcaa ggcggggaag aggccattcc 1340401 gcagaaataa acagcacgtt ggcgcctttt gtcgtatgtt ttctgatcca ttccggaaaa 1340461 cggatatcgt aacagatcaa tccagagctt ttgacgccgt caagctcaaa gtatccgtct 1340521 tcggaaccgg ctgataaata cagatgctca tccatcagct gaaaaagatg ggcttttctg 1340581 tactctttaa tgatttgccc ttccttatcc gcgatgtaca ttgtattata aacatcagaa 1340641 ttcttcctga cagcgaccga tccggcgaca atatgaacac catgtttttt tgccgttttc 1340701 ttcagccagc tctgagcgga gcggccgtct tcgtcagcga gttcatcaag attggccaga 1340761 tcatatccgg tcgtccataa ttcaggcaga acaagaacat cagcatgttt gctttctttt 1340821 tcgatgaaaa attcagcctt ttttatattt tccgaaggtt ttccgtatga aatatcaaat 1340881 tgaagacaag atatcgtcca tttcatcttt ttaacacccc aaatttttct ttactttttt 1340941 catttaacca tatatgatga tggactatca tttcaagatt tttttagaag gtgagaatag 1341001 atgaaatttg aacagtctca tgtattgaag gaattgccta aacaattctt cgcttctctg 1341061 gtgcagaaag tgaaccgaaa gcttgcagaa ggacatgacg ttatcaatct gggacaggga 1341121 aatccagatc agccgactcc tgagcatatt gttgaggaga tgaaacgagc tgtcgctgat 1341181 cctgagaatc ataaatattc gtcttttcgc ggctcatacc gtctgaagtc agcggctgct 1341241 gcattttaca aaagagaata cggcattgat ctggatccgg aaaccgaagt cgctgtatta 1341301 ttcggcggaa aagccggtct agtcgagctc ccgcaatgct tgttgaatcc cggtgatacg 1341361 attttagttc ccgatccggg ttatcctgat tactggtcgg gtgtcacact tgcaaaagca 1341421 aagatggaaa tgatgccgct cgtaaaggac agagcgtttc tccctgatta cagcagcata 1341481 accgctgaaa taagggaaca ggcgaaattg atgtatttga attatccgaa taatccgact 1341541 ggagctgttg ctacttccga gttctttgaa gataccgtgc gttttgcggc tgaaaacgga 1341601 atctgcgtcg ttcacgattt tgcttacggc gctgtaggat ttgacggctg caagccttta 1341661 agctttttgc agactgaagg tgcgaaggat atcggaattg aaatttacac gctgtcaaaa 1341721 acgtataata tggcaggatg gcgggttggc tttgccgtcg gaaacgcttc ggtcattgaa 1341781 gcgatcaatc tttatcaaga ccatatgttt gtcagtcttt tcagagcgac tcaggaggct 1341841 gcagcagagg cactgttagc cgatcagacg tgtgtggcag agcaaaatgc caggtatgag 1341901 agcaggagaa acgcttggat cacggcatgc cgggaaatcg gctgggatgt aacagctccc 1341961 gcaggttctt tttttgcatg gctgcctgtg cctgaaggct atacttctga gcagttctca 1342021 gatcttttgc tggaaaaagc gaatgtggca gttgcggctg gaaacggctt cggtgaatat 1342081 ggcgagggct acgtcagagt cggactttta acaagtgaag aaagacttaa ggaagccgct 1342141 tatcgaattg gcaaactgaa cctgtttacc caaaaaagca ttgacaagac cttataacga 1342201 tgggataatt caaaataatt tataaaatct atattttctt atcaagagca ggcagaggga 1342261 cgagcccgat gaagcccggc aaccgactta taaagcacgg tgctaattct tgcagctagc 1342321 ggctgagaga taagattcgg acgagaaacg aaacctcttt agacgcgatt gcagtttgaa 1342381 gaggtttttt gatatggatg aaaatgaaag gagctctggc atgagtgagt tattagcgac 1342441 atatctcctg accgaaccgg gagccgatac agagaagaaa gcagaacaaa tcgcaacagg 1342501 attgacagta ggctcctgga ctgatctgcc ccttgtaaaa caggagcaaa tgcaaaagca 1342561 caaggggcgg gtgataaaag ttgaggagag agagggaact gctgcatcag aaaaacaagc 1342621 ggtcatcaca attgcctatc ctgaaatcaa tttctctcag gatattccgg ctttgctgac 1342681 aacagtgttt ggcaagctgt ccctggacgg aaaaatcaaa ttaatcgatc ttcacttctc 1342741 tgaagcattt aagcgtgcac tgccgggacc gaagtttggc gtatacggca tccggaagct 1342801 gctgggagag tttgagagac cgctgttaat gagcatattt aaaggcgtaa tcggaaggga 1342861 cctgagtgat attaaagaac agctccggca gcaggcgctt ggcggagttg acttgattaa 1342921 agacgatgaa attttctttg agactggtct agcgcctttt gaaacaagaa ttgcagaagg 1342981 aaagcaaata ttgaaagaaa cgtatgaaca aaccggacat aaaacgctgt atgcggtgaa 1343041 tttgaccgga cgtacggctg atctgaaaga caaagcgaga cgcgccgccg aattgggagc 1343101 ggatgcgctt ttgtttaatg tcttcgctta cggcttggac gttatgcaag gccttgcaga 1343161 agatcctgaa atcccagttc cgattatggc gcatccagca gtgagcggag cgtttacgtc 1343221 ttctccgttt tacggttttt ctcacgctct tttactcgga aaattaaacc gatattgcgg 1343281 tgctgacttc agcctctttc cgtctccata tggttcggtt gcgcttccaa gagcagatgc 1343341 actggcgatt catgaagaat gtgtgagaga ggatgctttt aaccaaacat ttgctgttcc 1343401 gtcagcaggc attcatcccg gcatggttcc gctattaatg cgtgatttcg gcatagacca 1343461 cattattaac gccggaggag gcgtacatgg acatccgaac ggtgcccaag gcggggggcg 1343521 agcgttcaga gctattattg atgcggtcct agaggcccag ccgattgatg aaaaagccga 1343581 acaatgcaag gatcttaagc ttgcgctaga taaatgggga aaggctgaag ccgtatgacg 1343641 actcgaaaac cttttattat ttgtgatttt gacggaacaa tcacgatgaa cgacaacatt 1343701 ataaatatca tgaaaacatt tgctccccca gagtggatgg cattaaaaga cggcgtactt 1343761 tccaaaacgc tgtcaatcaa ggaaggtgtc gggcggatgt tcggccttct gcccagcagt 1343821 ttaaaagaag agattacaag ttttgtattg gaagatgcaa aaatcaggga aggctttcgg 1343881 gaatttgtag catttatcaa tgagcacgag attccgtttt atgtcataag cggtggaatg 1343941 gacttttttg tatatccttt gcttgaaggc attgtggaga aagaccgcat ttattgcaac 1344001 catgcttcat ttgacaatga ctatatccat attgactggc ctcattcctg caagggcaca 1344061 tgcagcaatc aatgcgggtg ctgtaagccg tcggtcatcc atgaactttc tgaaccgaac 1344121 caatatatca tcatgatcgg tgattcggtt acagatgtgg aggcagcaaa gctgtctgac 1344181 ctatgctttg caagggatta tttattaaac gaatgccggg agcaaaacct caatcatctt 1344241 ccgtatcaag atttttatga gatcagaaag gaaattgaga atgtaaagga ggtacaggaa 1344301 tggctgcaaa acaagaacgc tggcgagagc tcgctgaagt aaaacgggaa ttggcagaga 1344361 gagattggtt tccggcgact agcggcaatc tgtcaattaa ggttacagat gagcctttaa 1344421 catttctcgt cactgcaagc ggaaaagata aacgcaaaga gacggttgaa gattttctgc 1344481 tggtcgatca aaacggagag cctgctgaaa gcgggcattc tctgaaaccg tcagcagaaa 1344541 cgcttttgca tacacatttg tacaataaaa ccaatgccgg atgctgcctg catgtccata 1344601 cggtaaacaa taatgtgatt tcagagttat acggagacca aaagaaaatc acattcaaag 1344661 gccaggaaat tataaaagca ctcggcttgt gggaagagaa cgcagaagtg accgttccga 1344721 ttatagaaaa tccggcacat atcccgacgc tagcggcact gtttgcggaa gagatttcag 1344781 aagattcagg agctgttctg atccgaaatc atggtattac ggcttggggg aaaacagcat 1344841 ttgaggcaaa aagagtgctt gaagcgtatg aatttttgtt cagctaccat ttgaaattga 1344901 aaacactcga gcatcagctg gttaaataaa aggaggaatt gaaatggcta caattcgaat 1344961 tcatgatgag gcaaatacaa cgattgaaaa tcaagaggaa gtggcaagct ttctggacag 1345021 tcaagaggtt atttatgagc aatgggatat cacgaggctt ccggaacatc tctcagagaa 1345081 atatgacctg acagaagaag aaaaacagca aattcttgat accttcgaaa ctgaaattaa 1345141 agatatctca acccgccgcg gctataaagc acaggatgtt atttcattgt cagacagcaa 1345201 tccgaaactt gatgaactgc ttgaaaactt taaaagagag catcaccata cagacgatga 1345261 ggttcgtttt attgtaagcg gacacggtat ttttgtcatt caaggccagg acggcacgtt 1345321 ttttgatgtc cgtttaaacc ctggagattt aatctccgtg cctgagaata tccgccatta 1345381 cttcacgctt caggaggacc gcaaagttgt cgcggtgaga atttttgtca caactgaagg 1345441 ctgggttcct atttatgaaa aagacagcgt gaatcaataa gcgtgagata gccccgttca 1345501 tcgaacgggg ctttttatat ttattgcaaa cgccactttt catattgtga cagttctttt 1345561 ttaatcagtg tccaaatcaa acctaaaaca gctgcatcgt caatgaatcc aagaccgagg 1345621 attacgtctg gaatgatatc gagcggcatg acgatataca ggattgcggc agttaacagc 1345681 aaaagtgttt taacctgtga acgagggtag tcgccatttc gccaatcgcg aagcatctga 1345741 aaaaaagtag tgatgtgctg gatacatttt tttcggtttt tcctctttaa aatcgctttt 1345801 ccgcctgccg ctccgagcat tattgctttc tttttcttca ttgggcatac ctcctgcctg 1345861 gcggcgtgtt taagatattc ttcacctggg tattgttctt ctaatcctat caatatatct 1345921 attatacctg aaaaattaac ttatttaatg aaaatatgtt tacaaataaa gtataatctg 1345981 taataatgca caataaccca atcaaacttg tttcctattt cttagcggcg aggggtgaag 1346041 tgaatgggcg gttcttctga acaagaaaga ttgttggtgt ctattgatga aaaaagaaag 1346101 ttaatgatag atgccgctag aaagcaggga tttacagggc atgacacgat caggcacagt 1346161 caggagctgg attgtttaat aaatgaatat catcagctta tgcaagaaaa cgaacattcc 1346221 caagggattc aaggccttgt aaagaaatta ggcttgtggc cccgcagaga tgttatgcca 1346281 gcatatgatg caaataaata gcggcctatc agatgcatat ataaagagag agcttttcgg 1346341 aagcgctctt tttttctgga aaaaattcat atgaaagagg gaactaatga aggaactggc 1346401 gattctcatt accgaaatgg tcaatcaatt tcatgatgct tttatttcct tatgcggaat 1346461 atttggcatt catttaactg acaaagaaat gcatttttgg gtgatcggca tttttggcat 1346521 attctttttc ggcgtcactc acgctgtgtt tacatggctt tctaaatgga gtatgacagc 1346581 cttgtccttt atctataccg ttacagtcat cattgtcatc gtatttgcga ttgagattca 1346641 gcaaaaggtg acggggagag ggaatatgga gtttttagat gccacggaag gtataaaggg 1346701 ttttttagta ttttttatgt tttttttgct tttgaaaatg ctgttgcgtt tcatcaaaat 1346761 ccttttttct ggaagaccag caagcaaatc gaatggcaat gcccgatcac gaagataaaa 1346821 aaccctcctg acatggtcag gggggctatg atgcggatac ggggagggtg atcgtcacct 1346881 ctgtgcctct tcgcacttca ctttcaatat gaatagagcc tccgtacatc agcacgatcc 1346941 gtttacaaac aacaaggccg agaccggttc ctttttcttt agaagtaaca aagggaagga 1347001 agatgtgatc cagcatttcc tgagaaatcc cttcaccgtt atccacaact ttgattatgg 1347061 cttttttatc taaagctcct agggagatcg tcagtttgcc tccttcaggc attgactcga 1347121 ggccattttt tgctacattt aaaatcactt gtttaatatg atcttttgta cattttacga 1347181 gtaagggctg ctcggttaga tactgtaatt cgacttcaac attgtataga ttgccctcag 1347241 aataaatgat cggcataatt tctccgataa tgtcctgaag tgagttcagc tcccattttt 1347301 cagctgtcgg cttgccgaga acgagaaact cactcactat ttgattgatg cgctttatct 1347361 cctgttcgat aatggagaag taaagctgat cttcctcacc tttatatttc ttttgcaaca 1347421 gctgaataaa gccgcttatc ccggtgaggg ggttacggat ttcatgggct gtgctggcag 1347481 caagcgtccc gatcagctct aatttttgcg cctcgttttc tgagcgctcc agctgggtct 1347541 gccgcttcag caaataatac agcacgagaa taaaaaggat attcagcaga acaataatac 1347601 atgaaagcgg aagcacaagg cttttcgaca gttcttctat tgtgaccggg ttcggataga 1347661 ctttcatatt ccagctgata tcatccagat atccgctgac aggtttctga tcctctgcat 1347721 gagaggcttg tccgctcgca aaaatcattt tcccgtcttg gttcacaact tcaatataaa 1347781 catcagggct tagtaagtta atgagatttt tcaaataatc aatttgaata gctgcgacaa 1347841 gataatctgt cacattacgt tttgagtcca aaacaggcac acaaattgtg aaaattggct 1347901 gaccagtaat tctgctcgaa taactatctg aaatgactgt ctttttagtt tcctttgctt 1347961 ttataaaaaa agatctgtcg gccaggttta ctttcgtttt taattcggtt gtgcttgcgg 1348021 tgacgtctcc tttggcattg agaaaataga gaccggaaaa tctcggctct gaatcaaagg 1348081 tcttttccaa aattgattgc attttcttta tatcaaccgg tctgtcgatg gcgatggaca 1348141 aggaggtcat tctcgccatt gtttctccga ttaaataatt gattttgttg cggtgaaggt 1348201 ttagcaggac acttgcttct tgtttatgtt ctgcagctat tgtatctttt tctttttcat 1348261 atacgaaaaa gctgatgacg attgccggaa tcacgaccag tatgatataa agtttgactc 1348321 tcccgcaggc gccttttagt attttcaatt tgcatcgctc caacatacac ctgattagag 1348381 gtattatatc attgtttctt cttctttaat aagaaaaaat aaccaaaaaa attagaaaaa 1348441 gatgttggca agcttacatt ttaaaaaaga agagaaatat tggaaagatt tttattgaca 1348501 ttttggtctt tgtttattaa tgtttctctg taacggtttc taaaaggatg attgagacat 1348561 gacagaaaaa tcactgaagt tatttatcgt gctgtcgcgc gcgtatcggt ctattaacga 1348621 tcatatgaat aagcatattc ataagcatgg gctgaatccg actgaatttg ctgtgctaga 1348681 gcttttgtac cataaaggcg atcagccgct gcagcagata ggagataaaa ttctcttggc 1348741 tagcgggagc atcacatacg ttgtagataa gctggagcaa aaagaacttc tcattcggaa 1348801 agcgtctcct acagacagac gagtgacatt tgcgcaaatt actgaaaaag gcatcggtct 1348861 tttgaacgat attttccctg atcacgctgc tgaaattgat gaaatgatca gcgtattaag 1348921 cgaagaagag gtagagatgt gcaccgaaat gttaaaaaga gtaggattaa acgcaaaaca 1348981 gtttcataat aagtaaaaaa aggaagcctg atatgtcaca aggcttcctt ttttgctatt 1349041 tttcatttgt ttccgctgcg cctctcggca aaatgagaac ttcaacccgc cggtttttgc 1349101 ttcggccttc cgcagtttta ttggaagcca ccggtttata ctcgccataa cccttggcgc 1349161 tgaacacttt tgcatcgagc ttggggtttt caatcaggag ccccataaag tttaccgctc 1349221 tcatgacgct taaatgccag tttgattgga attcagaatt tttaattggc atattatcag 1349281 tatgtccgct gataatgata tttcttggcg ggttaatcac aagaagattt gaaatctctt 1349341 ttgcaagcgg cacatcttcc ttacggatgg tcgcttttcc agaatcgaag aagatgctgt 1349401 ctttaatcgt aatcagaagg ccttcactag tcatcttcgt ctccagctga tgttccagct 1349461 ttttatcttt gatgaacttt tccacctggc tcttcacatt ttcaagttct tcttgatcag 1349521 ctgctttttc tttttctttc ttgtttttct ctttctcttc tttttccttt ttcacttcat 1349581 cgatgccgtc tgactcgttt tcaggaggag tgacactgga gtagtccagt acaccggttc 1349641 cgcctgtaaa aacttcatta aatgattttg agagcatttg aaacttagct gcgtcaatcg 1349701 agctgctcgc gtacagcaca ataaacaatg ccaggagaag agtaaggatg tcggcgtaag 1349761 gaacgagcca tgattcatca acgtgctcgt cctcatgctt cttcttcttt tttctcgcca 1349821 ttttgcgcct ctccttgttc tgcaaatttc aagcggtcct tcgcaggaag atacattaaa 1349881 agcttttgtt cgatgacttt cggtgcttgt ccttctaaaa cggataaaac accttcaatc 1349941 atgacctcac gcagttttac ttcctgtttt gattttcgtt ttaatttatt tgcgaaagga 1350001 tgccataaca cataccctgt aaagataccg agaagtgtgg caacaaaggc agcactgatg 1350061 gcgtgtccaa gctcatctgt gttatccata tgagagagag cggcaatcag cccgattaca 1350121 gcgccgagta ctccaagtgt cggagcgtac gttcctgctt gtgtaaaaat agcggctcct 1350181 gcttggtgcc tgtcctccat tgcttcgact tcctctgtca taatatctct tataaattcc 1350241 gcgctttgcc cgtcaacagc catgctgagc ccgtttttca agaaagcatc atctacatcc 1350301 tcaatgcttg cttctaaagc aagcagacct tcgcggcgtg caagctgagc ccattcagag 1350361 aacataggaa tgagttcctc tattgtgagc tgtttatttt ccttaaataa cactcgaaac 1350421 agcgtaggca cttttttaat ttcttttgtt gggaacgcaa taacgactgc tgagattgtc 1350481 ccggcgataa taattaaaat ggcagcgggg tttgcaaggg cgctgaaact gacgcctttc 1350541 agaaccatcc cgacgctcaa tgccacaaaa gcaagaataa taccgattaa cgaagtttta 1350601 tccatagttt tcaccaaatc cttttttact agcttgtcta tggttaatat cggttttggt 1350661 gcccggaact ttagggacat tgtgaatttg ttcatgaaat attcaaggaa gaggcataga 1350721 agggagaaat aaacaaaaac gggctctcca aaattgaaaa gcccgggggt ctactgaaat 1350781 tagcagcttg cttgcaagct gtccttcaga tggtattcat ataatagtag aaatacatat 1350841 tcactgtata taaacatgtt ccatccctcc ttaaaaaagt gtaaaggatg aagggaagta 1350901 gcgcttcagg agaagggacg gtaatttcta agtcaagagt atgaaagtat aaaaaaaagc 1350961 ggcttcctaa aaggaaaccg ctgattgtta ttttgctcgc actttgattt tatcatcttc 1351021 taaaatcacg tgaaaacttg tgatctcgcc attatcaagc agcagatcgg tcatttcatc 1351081 ctcaacccat tcttggatgg ttcttctaag cggacgtgca ccgaatgaag ggtggtagcc 1351141 cagctcagcg attttttctt tcgcttcatc tgtcacattc aagctaatgc cccgttccgc 1351201 caatgtttct tcaagttctc caagaagaag gctgacgatt ttgacaagat gttctttttc 1351261 caatgagcgg aactcaataa tgctgtcaaa acggttgagg aactcaggtt taaagaacat 1351321 gctcagtgaa tcaattaatg tttgttcttc gatgacactg tcatctgatt ggaaaccgac 1351381 tttcgtttgt ttctcaccag cacccgcatt acttgtcatg atgatcacag tgtctttgaa 1351441 gcttacagtt ctgccttggc tgtctgtcag acggccatct tccataattt gcaggaacat 1351501 atgctgaacg tctgggtgtg ctttttcaat ctcatccagc aacacaatgc tgtaaggatt 1351561 gcggcgcacc ttctcagtta attgtccagc ttcctcatgg ccgacatatc caggcggtga 1351621 accgataatt ttagatacgg cgtgtttctc catgtattcg ctcatatcga gtcggataat 1351681 agcgtctttt gtgccgaata attcatctgc cagtgtttta gaaagctctg ttttccctac 1351741 gccggtagga ccgacgaaga ggaaggagcc gactggtctg tttttggatt ttaatccggc 1351801 gcggcttcgt cttaccgctt ttgccacttt ttgaacagcg gcttcttgtc cgatcacgcg 1351861 ttcatgaagt tttgcttcga gttctttcat tttcgtttgt tcgtctgcct gcagtttgcc 1351921 gacagggatg cctgtttttt gttcaacaat ttcctgaatg tgctcagctt ccacagtgac 1351981 agcggtatga gcggaggagc tgttcagttt tttctccaat gcgagttctt catcacggag 1352041 ttttgccgcc agttcgtaat tttcttcttc cagggctttt gttttttcgg cttcaattgc 1352101 agttaagcgt tcagcggcat cctcatcatt cagttcatca attaacaggt tggcttttga 1352161 acctgcttca tctaataaat caattgcttt atccggcagg tgtctgtcct gaatgtagcg 1352221 ggatgataaa gtgacacatg ctttgattgc ttcatcactg aatgttacgc catggtacgc 1352281 ctcgtatttg tctttaatcc cttgcagaat gaggatagcc tgttcaattg aaggctcctg 1352341 caccatgaca ggctgaaaac gtctttccag cgcggcatct ttttcgattt gacgatattc 1352401 tttcagtgtt gtcgcgccaa tgacttgcag ttcgcctctg gctagggccg gtttgagaat 1352461 gttgccggcg tccattgatc cttctgcaga gcctgcgccg acgagaaggt gaatttcatc 1352521 aatgaacaga atgacatttt ttcgttcctt cagctcagtg atcagctgtt tcattctctc 1352581 ctcaaattgg cctctgatcc ctgtgtttgc aacaagagat gcaacatcaa gcaagtatag 1352641 ctctttgttt tttagtttgt ttggaacatc accttcagca atttttaaag cgagcccttc 1352701 agcgatggca gttttcccta cacccggctc accaataaga accggattgt ttttgtttcg 1352761 gcggtttaga atttcgatca ctcgcgccac ttcatcatca cggccgatga cgggatcaat 1352821 gagaccggct tttgcaccgt ttgtaatatt ttgagccagc tcatcaagca accctttttt 1352881 ttcgctttgt tttgctgcgc tctgttcttt cggctggaat gcctgttcaa acggaaatcc 1352941 gaaagattga ggacccatac tcattgaagg tttacgggtc agttcgttat agcaagtttc 1353001 acaaagaacc atctgtttat gaacggaatt tatttgcatg ttaaggcgaa tcgtcgcctc 1353061 gttttgatga caatgttgac aacgcatttg ccaaaacctc cttaataatt tgatcatctt 1353121 tgaccaatga aagtgaataa aaaggtctat tgggtttgac cttctttgac tattagtata 1353181 cggcaaactt aacggcattc aaaccaatat gctcaaagca gactgaatat ttgactatct 1353241 ttgaccaatt gatttttaaa aaaggccggt ttgtttgacc aactttgatt aatagtatac 1353301 tctgactatc tttgactttc aagtcttatg cacaaaaatt tttgatttgt tacaaagtaa 1353361 aacatgtttt cttcgtcttt tcaaggaact tgtctcatag gttataaaaa ggcatatatg 1353421 gacaaaactg cggttcgttc ggagggaaga aatggaacaa tcaaaagggt ctgcaagtca 1353481 gcttgctttt gtgtatgtcg gcacagtagt cggagctgga tttgcgactg ggagggaaat 1353541 tgttgagttt tttctgaagt tcggctggtt cggttttttc ggcattctcg tcagcggcgg 1353601 aatgtttacg ttactggggg ccaagctgat gatcatttca aagcgaatca atgccaagtc 1353661 atatcaagaa atgaacatat ttttgttcgg ggcgacggct gggcggatta tcaatgtatt 1353721 tatgctgttt gttctccttg gagttacatc tgttatgctt tcaggggcag gggcgctttt 1353781 tgaggaacag ctggggatgt ccgctcagat tgggatgctc attacaatcg gtctgagttt 1353841 aattgtgatg actagaggag taaaaggcat tttcggtgtc aatgtgtttg ttgttcctct 1353901 tttaatcatc ttttcaatga ttgtggtggc cgactctttt atattcagcg aatcacgaaa 1353961 cgcagctcag tgggtctggc cgcatcgctg ggattggctg ttatcagcag tttcttacgg 1354021 ggctttaaat ttatcgcttg cccaagctgt tttggttccg ctggcgaatg aaatgtcatc 1354081 ggagaaagtg ataaaaaaag gcgctttaat cggaggcacg atgctgacga ttgtgctgtc 1354141 cgcgagtttt ctgtctttgt cgactcttcc ggatgtattt ttgtatgata taccgatggc 1354201 gcaagtggtt tatctctttg cacgatctgt ccatttgatt tatttactca ttattttcgg 1354261 agaagtgttc acatcagtta tcggtaatct atatggatta gaaaaacaag tgcaaagctt 1354321 tcttccagtg aaaagcaaat atatctttgc agccattatg atcacggctt atattacgag 1354381 ccaaataggg tacggcaggc ttatttcaac gatttatccc ttgtttggct atgtgagcct 1354441 ggccttcata ggcgctttgc tttgcaaaaa agctcctcgg cggcgcagtt tataaatata 1354501 tataatgaaa cgaaccgtca ctatagagcg ataattgatc taggaaccgg ggactgactt 1354561 ttttattgtc aagaaaaaca tcattatggt aagatagcag aagtgaaaaa attgaagaaa 1354621 atccgtgcga tatgcgggag aggttctagc tacaccctct ataaaaaact aaggacgagc 1354681 tgtatccttg gatacggcct tttttatgtt tttctagagc accttccgaa aaaaggtgtt 1354741 tttttgcgtg aattagctgt agcgatgtct ctcgccggcg tttttattgc ggagaaggag 1354801 aggaatcatg aaaaaagaaa aagcaattgt cgtatttagc ggcggtcaag acagcacaac 1354861 atgcttactg tgggccttaa aagaattcga agaagtcgaa acggtgactt ttcattataa 1354921 tcagcgacat tcgcaggaag ttgaagtggc aaaatccatt gcggaaaagc ttggtgtgaa 1354981 aaatcatttg cttgatatgt cacttttaaa tcagcttgca ccgaatgccc tgactagaaa 1355041 tgatattgag atagaagtaa aagacggcga actgccatcc acattcgttc caggccgcaa 1355101 tttggtattc ttatcctttg cgtctatcct ggcttaccaa attggcgcgc gccacattat 1355161 tacaggagtt tgcgagacag acttcagtgg ttatcctgac tgccgtgacg aattcgtgaa 1355221 atcttgcaat gtcacggtaa atctggcaat ggagaagccg tttgtgatcc acacgcctct 1355281 catgtggctc aataaggcgg aaacgtggaa gcttgcagat gagcttggcg cgctggattt 1355341 tgtgaaaaac aacacgctga catgctataa cggcatcatc gcagacggct gcggcgaatg 1355401 tccggcatgt caccttcgtt caaaaggtta tgaagaatat atggtgatga aaggagagcg 1355461 tgcataaatt gttatctcaa atttatccgc aggcccagca tccttattcg tttgaactga 1355521 ataaggacat gcatatctca gccgctcatt ttatccctcg ggaaagtgcg ggagcgtgca 1355581 gcagggttca cgggcatacg tataccgtaa atataaccgt tgccggcgac gaacttgacg 1355641 attcaggctt tcttgtcaat ttcagcgtac tcaaaaaact ggtgcacgga aactatgatc 1355701 acacgctatt aaatgatcat gaagattttt ctcaggacga ccggtattcg ctgccgacaa 1355761 ctgaagtcgt ggcgaaaacg atttatgaca acgtacaggc ttatttagac actttggaga 1355821 ataagccgac ctgtgtacag gtgtttgtcc gtgaaacacc gacaagctac tgtgtctacc 1355881 gtccgaaaaa gggtggtttg aatggctaaa ggaattcctg tattagaaat tttcggcccg 1355941 acgattcaag gagaaggcat ggtgatcgga cagaaaacga tgttcgtccg gacagccggc 1356001 tgcgattatt cctgcagctg gtgtgactcc gctttcactt gggacgggtc tgctaaaaaa 1356061 gatattcgct ggatgacggc ggaggagatt tttgcggagc ttaaggacat tgggggagat 1356121 gcgttttctc atgtgacgat ctcaggcggc aacccggctc tgttaaaaca gctggatgct 1356181 tttattgaac tgctgaagga aaataacatc cgtgcagcgc ttgaaactca agggaccgtt 1356241 tatcaggatt ggtttacgct gattgatgac ctgacaattt ctccaaaacc gccaagctca 1356301 aaaatggtaa cgaactttca aaagcttgac cacattttaa cttcacttca agagaatgat 1356361 agacagcatg ctgtcagctt gaaggttgtc atctttaatg atgaagatct ggaatttgcc 1356421 aaaactgtgc acaagcggta tccgggaatc ccgttttatt tacaagtcgg aaatgatgac 1356481 gtgcatacga cagatgatca gtcactgatt gcacatttgc ttggaaaata tgaagcgctt 1356541 gttgataagg tagctgtcga tgcggagctg aatctcgtca gagtgctccc gcagctgcac 1356601 accctgttat ggggcaacaa acgcggagta taatagaaag gaagatgaac atgacgacaa 1356661 gaaaagaatc agaattagaa ggtgtaacat tgctaggcaa tcaaggtaca aattatttgt 1356721 tcgaatatgc accggacgtg ctggaatcct tccctaataa acatgtaaac cgtgattact 1356781 ttgtaaaatt caattgcccg gaattcacat ctttatgtcc taaaacaggc cagcctgact 1356841 ttgcgacaat ctacatcagc tacattcctg atgaaaaaat ggttgaaagc aaatcattaa 1356901 agctgtatct attcagcttc agaaaccatg gtgacttcca cgaggactgc atgaatatca 1356961 tcatgaacga cttgattgaa ttaatggacc cgcgctacat tgaagtatgg ggcaaattca 1357021 cgccaagagg cggaatttcc attgatccgt acacaaacta cggaaagcct ggcacgaagt 1357081 atgagaaaat ggccgaatac cgtatgatga accatgattt gtatccggag acaattgata 1357141 atcgttaatt attccgttgt gtgatacgga gtgtaaaagg aagtggagtc acagtaaaat 1357201 ccgaacattc agcgttaatt ttcagcggaa atgtgacctg gtcacagcga agtgtgaccc 1357261 gcactaagct caataaaagt gggaaaagtc acacctgaaa atggctctac tcatgggaat 1357321 tgtattaaaa agtgtgacct gaggtgcaac ctgaactgtg acttttatgc agtgaaaaat 1357381 tgatagtaca gaagcagatt aaggcgtaca atttgtacgt cttttctttt ttatccgaaa 1357441 gaaaaaatgc ctatctagag atcataggca ttaaatatta ttatcaatat cttcatttat 1357501 tttttggcta agtttctgaa ccttctcttt aacatttgaa acagctcttt tttgaatttc 1357561 atcaattctc ctgaatatag tcgatgacac ttcttattag aacttcactt tcaaaattga 1357621 atatctcatt tatttctgac tgttcttcat ctgttaggtg atggtattga agttgtttag 1357681 catttacttc agcagctaca tcaatcctaa cttagttgtt ctggttgtac aatttcatat 1357741 tcaccttctg catactcttg ctccgcataa tagcctcccc attgacagag ctcctgcaag 1357801 ataggtttaa gagattctcc aagttcagtg gatgaatatt caaccttcgg cggtacttga 1357861 ttatacatct ttctgctcac aagtccactg gcttcaagct ctctaagtgt ttgaatcagc 1357921 attttctgag ttatatttgg gataatgcgc tttaattcac tcgttctctt tggtccattc 1357981 attaaaaagt ataatacaag gcctttccat tttccgccaa taacttcctt tgtcacttca 1358041 aacccacagc taaatttttt catgtctaaa gctctccatt ccacatttat tactttttag 1358101 ttactatatc acaaaaaagt gggtacttcc gataatgtgc ttactgaagg atactatatc 1358161 ttgtaagttg ttcttcaagt acttaaaggt actagacata aaataaaatt aattctaaag 1358221 gagtgttaag tatgggtaaa tttgaaggta aaatagcgct tgtaacgggt ggaacaagtg 1358281 ggattggtct tgctacagca caaaaatttg taaacgaagg tgcatatgtt tatattacgg 1358341 gacgtagaca aaacgaactt gataaagctg ttaaccaaat tggcaagaac gtaaccggtg 1358401 ttcaaggtga tatttctaag cttgaagact tagacaaact atatgacatt ataaagcagg 1358461 aaaaaggtaa gttggacatt ctttttgcta atgcaggcat cggcaacttc cttccattag 1358521 gtgaaattac tgaagagcag gttgatagaa cgttcgacat taacgttaaa ggaaccatct 1358581 ttactgttca aaaagcgtta tcactattcc cggacaaagt aggttctatt attgtaacgg 1358641 gctctactgc tggatcaatt ggcaacccag cgtttagtgt atatggagca tctaaagcag 1358701 cattaagagc actagttcgc aactggattc ttgacctaaa aggtactgaa atccgtgtaa 1358761 atgtggttag tccaggaggt attcttacac ctgcctacga tgagcttttt ggtgatgcac 1358821 ttgaagaggt actggaaaat agcagaaata ctgttccagc tggaaaagtt gggacacctg 1358881 aagaagtagc aaacgctgta tctttccttg cttcagacga aagcagttac ttgacgggtg 1358941 ttgaattgtt cgtagatggc gggctagcac aggtataatt tcactgcgca gagattacaa 1359001 atagtcccca aaaaaggtta atggggattt acttgaagaa gtcgtataaa aaagtcgttt 1359061 tccttaaagg acagggaatt cgactttttt atatttgaat ttgattaacg ttgtaaattc 1359121 gcattttcct ggggctacta ctaaatgacc tgtaaaaaag attacactgt gaataaatgt 1359181 acttaaagta acgggggctc ttgactttta ataaaaaata atatccctgt ccttgtattc 1359241 taatactttt aaaaatattt aaaggaatcc ttatgtcctg aataaccaca taggaaaata 1359301 tgttgtaggt tgctttcttt ttttgtgggg catcccacac aagctatctc gtgatctcac 1359361 acctgaacgt tttttataga ctagtaccgc gacaagttat attacatata cataccaata 1359421 aagtagacat taaaaagtga aagagaggat ggaaatgtgt gaaaattctt ttccttgaga 1359481 gtcatcccat gtggctctat ggtttaccga atgggtttag ggaagcagga cataccgtaa 1359541 tgatttccgg tcctgtaagt cgggaaaata taactgaaat gatagacgaa tttaaaccag 1359601 atttaatagt atctatggga tggacaccag agcattcaag ggaaaagcag gcctggattc 1359661 gcaacgctac taaaaaggtg aatatccctc tcgtttattg ggcaactgaa gacccgctgc 1359721 acactcaaaa ctttactatc ccgttaatta aaaagatgaa accggatttt gttttcacgg 1359781 tcacgccttc tctgtgtaaa acttatgaaa gcatggggat taaagcagct cacttagact 1359841 ttgcatttca cgaaagtata catcaccaga ttaaaccatt agcgaaatac agttgtgata 1359901 tagcagtggt ggctaatgct taccctaatt ttcttgaaga acatccggaa gtgttccgtt 1359961 cgtcctcttt aaaaacgctt attcgtcctc ttatacggaa gggtattcgc attgattttt 1360021 gggggagaaa ctgggaaaaa atgagtaaat atataggaag agaaattccc cgcaattgga 1360081 tccatggata ccttgattat actgaagcat ataaagttta cagttcagca aaaatcatta 1360141 tcggtttgca aaactgtgaa agccaactta cacaacgcac ctatgagatt cttggttccg 1360201 gggggttttt attgacatcg gatacaccag cagttcgagg taaattcaaa cctggccgcg 1360261 atctcatcgt ttcttcctcc ccaaaagaaa cattggaaaa ggttaaatac tatttaaatc 1360321 atgatagcga gagaaaaaag attcagataa acggtaaaaa ggctgtaaag aatgattcct 1360381 atcggcatag agccgagaga atgcttgagg tgctaaaaag cagaggaatc ataagaaact 1360441 taggggaaac cattcattat gtagatgttc tcaaagaaaa atacgtgatc catcatgtta 1360501 ctcccggtga aacattatca ataattgcca gtaagtataa tgtttccctg cagcaactca 1360561 tggagcttaa tcatttcaaa tcagatcaaa tatatgctgg acaaatcatt aagattagag 1360621 agaaactgtt tagaaatatt aataacaaat tattctaaag gagagtaata tgaatgaagg 1360681 ggaaaatacc taaaataaga aatcaagcga ataaagtaaa aagaacgcct cgttatatgg 1360741 aatttcccgt gacatacgaa gtatatcatg tggaatccgg cgatacatta tggacgattg 1360801 ccaaatcctt tgaaattccg gtacaacaac ttatgaatct taataagctt tcttcagata 1360861 gaatttatcc tggacaaatt ataaagataa gagaaagata atctttgagg tttcggaagc 1360921 gaatcaaatt gaaatgacaa tcctcatttt tttatttgtg gggaacttga tatttttggg 1360981 gatgaagggg ttatgagatg tttcaaatga gctattacta ttctggatta ggatgggact 1361041 ttattcaaca cgttgatcaa acgaacggag tattaaatgt tgtgtctcct gattttttct 1361101 atatcagaaa agatggatca ttacttctcc gttcagctaa tcccgatgtg attaaagctc 1361161 ttcatagaag aaaattaaaa gtagttcctt ttctaagcaa tcattgggat caggatttgg 1361221 gacgatttgc attaatgaac cgagttcttt tagctaaaca aatttctcat gcaatagaag 1361281 aactggattt ggatggagtt aatatcgata tagaaaacct tacagaaaaa gatcggaatc 1361341 tatttacaga ttttattaga ttagtaagga aaagtattcc tagacataaa gaagtatcag 1361401 ttgcagtggc ggcaaatcct tttggctgga cgaagggctg gcacggatca tatgattacg 1361461 agtatttagc taaatatgca gattatctta tggttatggc ctatgatgaa agccgccttg 1361521 ctgggcctac tgcaagtgta ggatgggtgg aaaagtccat tcaatatgtt ctgacccaaa 1361581 aaatctctcc tcaaaaacta gttttaggat tgccattcta tggccgctgc tggatggaag 1361641 gccaatctgc ctctcaagcc attccccttt accttgttgt tagtaaaaag gcatagcggg 1361701 acaattattt ttgacaccaa gagtcaatct ccaaaagcta tttttactgt caatcacgat 1361761 aaaaaggggc cgttgccttc gggaacatat acattatggt ttgaaaatga acagtcactc 1361821 agagcaaaaa taaaactcgc tcaaaaatat aatctgaaag gtcttggcag ctggagtctt 1361881 ggacaagaag atgcgtcagt ctggaataca gtgtttaaaa atatataatg atttatagtt 1361941 cagaacaaaa ttcgaagata attgcaatga atctctaaat ggacatactg aaaggagttt 1362001 attacgagtg cgggtaaaac agtgagggca ttccataggc ccttctccca aaatgttcta 1362061 cacgaggcat tacattgggc ttgaaataca cattcaaact tatgttatag tacgcatttt 1362121 acggatgtgt tgaatttatt ctgcttccat gatttaatca tacacatgct acttgatagc 1362181 agggttatcg catttcattc agaattgttc aggatcgata tggaagcgca cgactaacta 1362241 gaactttaaa agcatacact catatacttc ctgaatggat gctggtttat ctaaaaaaca 1362301 tgatgagaat tgattgtacg catggtgaag catgacttgt tgataatcga ccatatggtt 1362361 tctccttaga aatgaggggg tttttacata aaaaagacga gcgaatccgg ggggaattcc 1362421 actcgccgct ttctaatgaa aagacgggat gctggatggc agctcgtctg ttttattata 1362481 atttaacgaa cgtatgtttg taaaggtgtc ttttcgaatg aattggttca tataaccgtt 1362541 aagaacagat tcattgtaaa cattcgctaa ggtatgctaa gatgcatgga ctataaagga 1362601 gtgatatgaa gtgaagacat tgcggttaaa caatgtaacg ttagaaatgg ctgcatatca 1362661 agaggagagc gagccgaagc gaaaaattgc atttacctta aacgttacga gtgagactta 1362721 ccatgatatc gctgtcctgt tgtatgaaaa aacgtttaat gtcgaggttc cggaacgcga 1362781 tcttgccttc cggggggaaa tgacaaatta ttcaacatca ttgaccaacc tgtacgaacc 1362841 aggggccgtc agcgagttct atatagaaat aacggaaata gacaaaaacg ccgattcatg 1362901 atcggtgttt tttatgtaaa aaagctgccg gccggcagct tttgagaaag cgaatttcat 1362961 atgtaaggtg ttaaattgtc cgtcttgcag ttttttgaat aaatgtggaa ataaggaggt 1363021 tttaatagga gtctctgatg atcttataat ttttatgatt aacaactgtc aatgaatcta 1363081 actcaagatc ccgatagtta tccatgatcg tcacatcaac gataacagaa ttctcattta 1363141 ctttttcaac aacaccggtt aatccgtttt taaattcaat gacattccca accttagcga 1363201 ttttcacaag cttcctctcc tttaaacata ataatgcctt ttgaaagtat tttgcagtat 1363261 tttcattgag aagtaaagcg ataaggagtt ttatctccct tatgaattgt tctgtcgcta 1363321 taaagatgat atattgattt tcgtcaatag aaagaaaagg ggggaatttt tgttgcgtcc 1363381 cgaagaaata acagaaatga ttgaacagct gcgcaccggc gccataaacg aactgagagt 1363441 ccagaaagag cattttcttg atttcagggc cgtgttatct aaacaagatg attttaaaca 1363501 tttccgagga attgcccagc aaggcggaga tgttatcttt caatacttag aacagccaag 1363561 aagctgaagg tttctcatac gtgagaagcc tttttatcat atatgacaga acacaagcct 1363621 tttattacag ctgtctgtaa caggtgtaaa taaaatgtaa agtaccaaag atggataaac 1363681 atgttttaat ttaacaatat ttatagaatt tcagactgtt tttttgccat taagcagtga 1363741 gtcatcctct ttattccatc ctgatacctc cttgggagag ttggaaaatc tttttccgtg 1363801 aaaatgaatg gatctcttgt taaggttatg aagtgttttt tggagcactt taaggaggaa 1363861 actgtatgac aacgaaattc actgctctgg ctgtttttct tctttgtttc atgcctgcag 1363921 ccaaaattga gcatacacaa gcttcactac tgagcgcaaa gaagacaaaa catgaagaag 1363981 cgaaatggct tacacatata gatcgaaata cgaatgaatc tttcccttca ctgtctgctg 1364041 ataaagacaa gaaaataaaa ccgattaagc tatcagcaca cactgaaaag aaagagaaag 1364101 ataaaccgga caaaacaaat gatgagaaag aaacatatac acagtctgaa aaagagttgc 1364161 tgtcccgtct cgttcacgca gaggccaaag gagaatcata taaaggcaag gtcgctgtag 1364221 caagcgttgt actgaacagg acggagaaaa aaggttttcc tgatacgata agaggagtta 1364281 tttatcagaa aaacgccttt gaaccggtcg caaacgggag cattaaccaa aagcctgata 1364341 aagaatcgat tgaagctgcc gaagaagcgc tgtcctcaaa aaatagagaa acagatgcca 1364401 tattctttta taatccgaaa acagcgtcag ataattggat tcgttcaaga aaaatcgtag 1364461 aaaaaatcgg cagacacgtt tttgccgtct aagcatagaa gagacaattt gtctcagctg 1364521 tgcttttttt catataaaga gtaaaaataa aataattttt gaacttgtct catatgatgt 1364581 tggtagtaca agagacaagg agagacatca tgaatcgatt tgtgaaaggg atcattcttt 1364641 tatccattgc cgcctttttc gctgaatgcc ttgaatttgt cgtcaatatg attttggcgc 1364701 gggagcttgg cgagcatggg atggggcttt acatgagtat tttgcccacg atctttttaa 1364761 ttattgtcat cgcgagcctg gaactgccga tatccatttc taaattcatt gccgagtcaa 1364821 atcctaagct tcatgaaagc atgctgaggc acgctttcag aatgacagcc atttttactg 1364881 ctttttctac tgccgccgct agtattgcgc ttccgtttat tccggtattt gatacatacc 1364941 acccgtttat taaagggatt gtcatcggct taattcctgt tgtcgccttt acttcaatcg 1365001 ccaggggcta ctttatgggt gtgcagaaaa tggggaagat cgcaattgcc aatgtgctga 1365061 aaaaaatcat ccagctcttg tgcttattcc tcttttttca atggtactca tttgaattgg 1365121 acatggctgt gctgatttcc ttgtttgttc tagtcgtgag tgatgtggtc gtgcttgttt 1365181 atttatattc acaatttatc atggcaaggc gggcgttatc cggccagcag cacattcatt 1365241 tgcgcggaaa ggatgtaagg aaaagactgc ttgctgtttc aattcctaca acaggactgc 1365301 gtatttttca tgcggttgtc aatgcaattg aacccttttt agtaaaagga gctcttttgg 1365361 ctgcgggcgt tgccgggaca gcggcgatcg atcaatacgg aatgctggca ggagtggctg 1365421 tgacgatagg gtcgttccct gcttttattg cccattcgtt aatggtcgtc atgataccga 1365481 gtatttcgga agcttatgca ctttctcagt atgacatcgt gttaaaaagg ctgaagcagt 1365541 cgattttcat tacattaggt tacggtatac ctgccgtctg ggtcatgttc cagtttgcgg 1365601 gacctctcac gcatttgttt tttcactctc ctgaagcgca gtattacttg cagctgttgt 1365661 ggccttactt tctctttcat ctgtttgtca tgccgctgca ggcgtgctta atcgggatgg 1365721 gttttgtgaa agaggctttt tatcacaatg tatggagcca tatcgttgcg ctaagtatga 1365781 tgtatgtact gggatcaatg gagaatctgc aaatgctcgg gattatcctt ggaatgaaca 1365841 ctggcatgat tcttttgacg agcctgcact atgccacgat ctgcaaagca ttgaaggtat 1365901 ctgtatttct tacgggaggg accagaacgc cgcgaattga aggatgataa aggaacagca 1365961 ggggcaagct aattgaaaag catgaaagga agattccatg ttgacgaagc gcttgcttac 1366021 tatatacatt atgttattag ggttgattgc atggtttcca ggtgcggcac aagctgagga 1366081 aaaacagcct gctgttcccg ctgtttttct tatgaaaacg atagaagggg aggacatctc 1366141 gattccgaat aaagggcaaa aaacaattct ccatttttgg acgtcatggt gcccgccctg 1366201 caaaaaggag cttccacagt ttcaatcgtt ttatgatgcc catccatccg acagtgtaaa 1366261 gctggtaacg gtgaatttag tgaattcgga acaaaatcag caagtcgttg aagactttat 1366321 taaagcaaac aagctgacgt ttccgattgt ccttgactca aaaggggaat tgatgaagga 1366381 gtatcatatc atcacgatcc caacatcatt tttgctgaat gaaaagggag aaattgaaaa 1366441 aacaaaaatt ggcccgatga cagcggaaca actgaaggaa tggacggaag aatagctgag 1366501 agcatagact ctcagctttt ttcatataga gaagaagtga ataaacatta atgataatta 1366561 ttatcaaaaa gaaattaaaa taattataat tgaaattctc ttcgtgcgtg ctataataaa 1366621 ggaagacatc aagaaataac tgacgataaa gctgcctttt gggcagcgat tttgttttta 1366681 taagagaaat gaagatgatt tacgttctca attagagagg agaattcgat atgaatgaac 1366741 aagttatcgt tcaacgcgac ccgcatgagc cattgaaaac agacaagagg gaaaaaaact 1366801 gggcacagca cgcggagctt attgcagcac ttgtatcagg cgctcttatt ttggcaggct 1366861 ggctcttatc cggatatcag gtattatcca taatactttt cttgctggct tttgtgatcg 1366921 gcggatttgc taaagcgaag gaaggaatcg aagaaacact cgaatccaaa acgctgaatg 1366981 tagaactttt aatgattttc gctgccattg gttccgcctt gatcggatac tgggcagagg 1367041 gtgctatttt aatatttatt ttttccttaa gcggagcttt agaaacatac acgatgaata 1367101 aaagcagcag agatttaacg tctttaatgc agcttgagcc tgaagaagcg acattgatgg 1367161 tcaatggtga aaccaaaaga gttccggttt cagacttgca ggccggtgat atgattgtga 1367221 tcaaacctgg agaacgcgta gcggcagacg gtatcattga atcgggctcg acaagtcttg 1367281 acgagtcggc tttaacaggt gaatcaatgc ctgtagaaaa aaacacaggc gacactgtat 1367341 tcacaggaac ggtgaatcgc aatggctcct tgacagtccg tgtcacgaaa gcaaatgaag 1367401 attcgttatt cagaaaaatt atcaaactgg ttgaatcagc gcaaaatagt gtttcacccg 1367461 cgcaggcttt catcgaacga tttgaaaatg cttatgtgaa aggtgtgcta attgcggtgg 1367521 cgctcctttt attcgtcccg cactttgcgc tgggctggag ctggagtgaa accttctacc 1367581 gcgcaatggt gtttatggtt gtcgcgtcac cttgtgcgct tgtcgcctct attatgccgg 1367641 cggcgctgtc cctgatttca aatggcgccc gcaacggtat gcttgtgaaa ggaagcgtct 1367701 ttcttgaaca gctgggctca gtgcaaatga tcgcctttga taaaaccgga actgtaacaa 1367761 aaggccagcc tgccgtagag acgatcagaa tagcagaagg attcagtgaa gcggaagttc 1367821 ttgaggctgt ctatgccatc gaaacgcaat caagccatcc gctcgcccaa gccataacgg 1367881 cgtacgctga aagccgcggc gtgaatcagt ccggctacat atctatagaa gaaacctcag 1367941 ggtttggcgt tatggcagaa gtgtcgggtg cgaaatggaa ggtcggtaaa gcaggtttta 1368001 tcggcgagga aatggcagca caatttatga aacaaacagc atcagatgtc attcaaagcg 1368061 gtcatacaat tgtatttgtg aaaaaggatg atcaaatagc aggctgtatc gcactgaagg 1368121 accaaatcag gcctgaagca aaagaggtca tggaagaact gaaccgactt gggattaaaa 1368181 cggccatgct gacaggagat cacgaagaca cggctcaagc gattgccaag gaagccggca 1368241 tgacaactgt cgtggcagaa tgcctgcctg accaaaaagt gaatgaaatc aaacggttaa 1368301 aagaagaatt cggaacgatt gcaatggtgg gtgacggaat caatgatgcg ccggcactca 1368361 aagcagcgga tgtcggcatt gcgatgggcg gcggaacaga tgtagcactt gagaccgctg 1368421 atatggtcct catgaaaaac gatttgaaaa agctcgtaaa catgtgccgc ttgtctcgga 1368481 aaatgaacag gatcatcaaa caaaatatcg tgttttctct agctgtaatc tgcctgctga 1368541 tttgtgcaaa ctttttgcag gcgatggaat tgccatttgg cgtgattggt catgagggca 1368601 gcacgatttt agtcatacta aacggtttaa gactcctaaa ataaaaccag cagcctaatc 1368661 aggctgctgg ctttttatgt atcaagcttt cccttcattt ttgtctttat cagatctttt 1368721 cataactagg atgagagcga gggtgcagca aaggaaaccc gctgcacagc ctatgataga 1368781 gctgtaataa taaaagccca ccatcttcat cccgataaaa ggagcggaaa ttcccaaaac 1368841 cgttaagagc ataactgctt ttcgtctgaa aaaattcatc agcaaacgga acaacccccc 1368901 tgcgattgaa cgttactgtc agtatacagg aagaggagca ggaaataaaa tgcattagaa 1368961 aatgaaggcg tcgtgaaagg caaacaccgg taaaacctgt tacaatggaa gacagaacaa 1369021 tgcattgcaa atggcaggga ggaacaagaa gtgaatagaa tacaacgcgt ctcttcatgg 1369081 ctgaaggaag cggggcatac tgccgcattt attcatacga aagaaaatgt tttttactta 1369141 accggttttt acacagagcc gcatgaaaga ttaatggggt tatttatttt tcaagaagag 1369201 gagcctttct ttgtttgtcc aggaatggaa gcaggacagg cccgcaacgc aggctggaat 1369261 catgaaatca ttggctatgc ggatcacgaa aatccgtggg agctgataga gaaggctttg 1369321 aaaaagcgaa atatcagcat acatatgctt gcggtagaaa aggattcaat ctcgctgtca 1369381 cgtgcagaac agctgaagca tgcgacgggc ggggctcaat ttgtttcagc agaagaaaca 1369441 ctcaatcaat ttcgcctgat taaagatgac aatgagattc gtttgctgaa agaggcggca 1369501 aagcttgcag attacggtgt tgaagtcggc acagccgctt tgcgtgaagg catcagtgaa 1369561 gtggaagtgc tcgctcaaat tgagtatgag ctgaagaaaa aaggaattca gggcatgtct 1369621 ttctctacaa tggttttatt cggagaaaaa tctggccagc ctcatggaaa tcctggtaca 1369681 gccacgttga agaaaggtga ttttgtttta tttgatctcg gtgttattct tgatggctat 1369741 tgctctgata ttacaagaac gtttgcatac aaaaccatca atccgaagca ggaggccatt 1369801 tacgagactg tgcttcaagc ggaaaaagcc gcgattgagg caagcaaacc cggtgtgaga 1369861 atcggagatc tggatttaac tgcccgcgga atcattgaaa aagcgggata tggtgattat 1369921 tttcctcacc ggcttgggca tggactcgga atttcagtcc atgagtatcc atcaatgagc 1369981 caggccaacg atacactgct gcaggaaggc atggtctaca cgatcgaacc ggggatttat 1370041 gtgccagaga tcggcggcgt acgcattgag gatgacgttc acgtaacaaa ggacggagca 1370101 gttgctctga cccaatatcc aaaggatttg atcatactgt aatagaaata aaaaaggact 1370161 ttgttctcga catcgtcctt ttttatctgc attaaataaa aaaatcatca aatgttcgaa 1370221 agggtttaat ttcatgtttt tggttgagag gttttacagc aagacagctg ccaccgagaa 1370281 cagtgagaca taacccaatt aaaatgaaga aacccatgtg atcttctcct ttcagctaaa 1370341 aacacaaaaa gatatctggt acgtccatat catattgtat gaaacgcatt ccagatcaag 1370401 gggatttaga aagaagggaa tctatggcta atattaaaga cattgcagag aaagccggtg 1370461 tctctgttac aacggtttcc cgagtcataa acaatcatcc atacgtcagt gaagacaaac 1370521 gaaaaagagt gtttgaggca atggaatcat tggagtacac gagaaatatt cacgctgtac 1370581 atttgtcgaa aggattttca aacatgattg gtgttgtctt gccgacggtt aatctgccat 1370641 attttgcaga gctgattgca ggaatagccg acgcagccgc ggaatccggg gttcacctct 1370701 ctttattcca aacaaactat gaagtacaaa aagaaatctt tgcgctgtcc caattaaagc 1370761 agcgccaggt tgacggcctg attttttgct caaaggcgct tgctgatgag aaactcatgg 1370821 aatgggaggg cccgattttg ctttgccaga attcagataa tgcccgcttc ccaaccatca 1370881 gcattcctca ccaagaagca tttcggaacg gcttggacta tttaattgcc aaagggcaca 1370941 aaaaaatagc catctgtttg gcaagaaaaa aaggcatgaa cagccatttt cgaatcaaag 1371001 cctacaaaga ggcattggaa gagatcggcg aggcatttcg tgaagactgg gtaattgaga 1371061 aagcgattac aatcaatgat gggaaggcgc tttttcataa atggaatacg tggaaggaaa 1371121 agccgacggc tatttttgtt gccaatgacc aagtctcagc agggcttttt cttgaagcaa 1371181 agaaccagcg ggtgtcagta ccggatgagc ttgcaatctt aagcgttgat aaccacgaaa 1371241 tcagccaagc gcttggaatc acaacgatcg atattcagac aagggaaatg ggaaagcagg 1371301 catttgccat attggaaaaa agaattcaag gacagccgat tgaaaggaaa gttctggatt 1371361 accgtctcat cgaaagatcg actgtttagt gaatgcattg aaaaaaggtt tgacgtgcat 1371421 tctgttcgtt atgtacgata tgaggtattg aatgacaaag gagctgagga tcgtgaatgg 1371481 gtccttcaca gtgaaaaagg tactgaataa taacgtatta attgcttctc atcataaata 1371541 cagcgaagtc gttttaatcg gaaaaggtat tggtttcgga aaaaaacaag atgatgtcat 1371601 tgaagataaa ggctacgata aaatgttcat tttaaaagac gagaaggaac aaaagcagtt 1371661 taaaaagctc cttgactatg ttgatgaaaa gctcgttgat atttcaaacg atgtcatcta 1371721 tcacataagc aataggacga atcactcatt aaatgaacat attcacattg cgttgacaga 1371781 ccatatcgca tttgcgatca aaaggcagca gcagggattt gatatgaaaa atccatttct 1371841 aatggagact cagtcactat atcctgagga gtaccaaatt gccaaagaag tcatagatat 1371901 gatcaatgaa aaagcgggac tctgccttcc ggaaggggag attggtttta tcgctctgca 1371961 tatccattca gcgttgacaa accgtccgct gtccgaggtc aatcagcact ctcagctcat 1372021 ggcgcagctt gtcgaggtga ttgaagactc atttcaaatg aaagtaaata aggaaagtgt 1372081 caactatttg cggctgatca ggcatatcag atttacaata gaaagaatta aaaaagaaga 1372141 accgactaaa gaaccagaaa aattaatgtt gttattgaaa aatgaatatc cgctatgcta 1372201 caatacagct tggaaattga ttaaaatctt gcagcaaaca ttgaagaaac cagttcatga 1372261 ggcggaagcg gtttatctga cgcttcatct gtaccgatta accaataaaa tttcataaat 1372321 tcagtttatc cttataacgt gttactgatt cgatcaggca tgagtgattg agggaaaaaa 1372381 acgggaagtt cattctcgtt cttttgcgca cccaattttg ctcatgcctt tttgttgtgt 1372441 aaaagggcaa atgtaaacgg ttaaactgga agacttacgc ctgtgaattc gttgtcatga 1372501 tttttagctg taaggtcaga ctagtaaaaa gaggaggtca attcttatgt ttaaagcatt 1372561 attcggcgtt cttcaaaaaa ttgggcgtgc gcttatgctt ccagttgcga tccttccggc 1372621 tgcgggtatt ttgcttgcga tcgggaatgc gatgcaaaat aaggacatga ttcaggtcct 1372681 gcatttcttg agcaatgaca atgttcagct tgtagcaggt gtgatggaaa gtgctgggca 1372741 gattgttttc gataaccttc cgcttctttt cgcagtaggt gtagccatcg ggcttgccaa 1372801 tggtgatgga gttgcaggga ttgcagcaat tatcggttat cttgtaatga atgtatccat 1372861 gagtgcggtt cttcttgcaa acggaaccat tccttcggat tcagttgaaa gagccaagtt 1372921 ctttacggaa aaccatcctg catatgtaaa catgcttggt atacctacct tggcgacagg 1372981 ggtgttcggc ggtattatcg tcggtgtgtt agctgcatta ttgtttaaca gattttacac 1373041 aattgaactg ccgcaatacc ttggtttctt tgcgggtaaa cgtttcgttc caattgttac 1373101 gtcaatttct gcactgattc tgggtcttat tatgttagtg atctggcctc caatccagca 1373161 tggattgaat gccttttcaa caggattagt ggaagcgaat ccaacccttg ctgcatttat 1373221 cttcggggtg attgaacgtt cgcttatccc attcggattg caccatattt tctattcacc 1373281 gttctggtat gaattcttca gctataagag tgcagcagga gaaatcatcc gcggggatca 1373341 gcgtatcttt atggcgcaga ttaaagacgg cgtacagtta acggcaggta cgttcatgac 1373401 aggtaaatat ccatttatga tgttcggtct gcctgctgcg gcgcttgcca tttatcatga 1373461 agcaaaaccg caaaacaaaa aactcgttgc aggtattatg ggttcagcgg ccttgacatc 1373521 tttcttaacg gggatcacag agccattgga attttctttc ttattcgttg ctccagtcct 1373581 gtttgcgatt cactgtttgt ttgcgggact ttcattcatg gtcatgcagc tgttgaatgt 1373641 taagattggt atgacattct ccggcggttt aattgactac ttcctattcg gtattttacc 1373701 aaaccggacg gcatggtggc ttgtcatccc tgtcggctta gggttagcgg tcatttacta 1373761 ctttggattc cgatttgcca tccgcaaatt taatctgaaa acacctggac gcgaggatgc 1373821 tgcggaagaa acagcagcac ctgggaaaac aggtgaagca ggagatcttc cttatgagat 1373881 tctgcaggca atgggtgacc aggaaaacat caaacacctt gatgcttgta tcactcgtct 1373941 gcgtgtgact gtaaacgatc agaaaaaggt tgataaagac cgtctgaaac agcttggcgc 1374001 ttccggagtg ctggaagtcg gcaacaacat tcaggctatt ttcggaccgc gttctgacgg 1374061 gttaaaaaca caaatgcaag acattattgc gggacgcaag cctagacctg agccgaaaac 1374121 atctgctcaa gaggaagtag gccagcaggt tgaggaagtg attgcagaac cgctgcaaaa 1374181 tgaaatcggc gaggaagttt tcgtttctcc gattaccggg gaaattcacc caattacgga 1374241 tgttcctgac caagtcttct cagggaaaat gatgggtgac ggttttgcga ttctcccttc 1374301 tgaaggaatt gtcgtatcac cggttcgcgg aaaaattctc aatgtgttcc cgacaaaaca 1374361 tgcgatcggc ctgcaatccg acggcggaag agaaatttta atccactttg gtattgatac 1374421 cgtcagcctg aagggcgaag gatttacgtc tttcgtatca gaaggagacc gcgttgagcc 1374481 tggacaaaaa cttcttgaag ttgatctgga tgcagtcaaa ccgaatgtac catctctcat 1374541 gacaccgatt gtatttacaa accttgctga aggagaaaca gtcagcatta aagcaagcgg 1374601 ttcagtcaac agagaacaag aagatattgt gaagattgaa aaataagggt gttagtacgc 1374661 cgtgcttgtc agatgacaag tacggttgta tgatataata ttgtgaagta ataaagcttt 1374721 aagttaaaag gagaatgata aaaatggcac aaaaaacatt taaagtaact gcagattctg 1374781 gaatccatgc tcgtcctgcg acagttcttg tacaaactgc tagcaaatac gacgctgacg 1374841 ttaatttaga atataacggc aaaacagtta accttaaatc tattatgggt gttatgtctt 1374901 taggtatcgc taaaggcgct gagatcacaa tctctgcttc cggagctgac gaaaacgatg 1374961 ctcttaacgc tttagaagaa acaatgaaaa gcgaaggact cggcgagtaa tgcaagaatt 1375021 aaaagggatt ggtgcttcag ccggcatcgc gattgcaaaa gcgtaccggc ttgaagagcc 1375081 agatttaacg gttgaaaaga aaaacatctc tgattctgaa gcggaagtaa gccgttttga 1375141 tgaagcgatt gcacgttcaa aagaagagct cgaaaaaatc aaagagcacg ctttgaaaga 1375201 actgggtcag gataaagctg atattttttc tgctcacctt ttagttctca gtgaccctga 1375261 gcttctgaac cctgtgaaag aaaaaatcag cactgattca gtgaacgctg aattcgcttt 1375321 aaaagaaacg tcttctatgt tcgttactat gtttgaatct atggacaacg aatatatgaa 1375381 agagcgtgcg gcagatatcc gcgatgtaac aaaacgcgta accggccacc tgcttggcgt 1375441 cgaaattcca aacccaagca tgatctcaga agaggttatt attgtagctg aagacttaac 1375501 accgtctgac acagctcaat taaaccgtga gttcgtaaaa ggattcacta ctgatatcgg 1375561 cggacgcaca tctcactctg ccatcatggc acgttctctt gagattccag cagttgttgg 1375621 aacgaaagct gctacaggca cgatccaaaa cggcgtgact gttatcgttg acggtatcaa 1375681 tggcgatgtc attattgacc catctgcgga aactgtaaaa gagtatgaag aaaaacataa 1375741 tgcttatttg gctcaaaaag ctgagtgggc gaagcttgtc aatgaaccga ctgtctcaaa 1375801 agacggacat catgtagagc ttgcagcgaa catcggtact cctgatgatg taaaaggtgt 1375861 tcttgaaaac ggcggagaag cagttggcct ttaccgtaca gaattccttt acatgggaag 1375921 agatcagctg cctacagaag atgagcagtt tgatgcttac aaaacggttc ttgagcgtat 1375981 ggaaggaaaa tcagtcgtcg tgcggacact tgatatcggc ggagacaaag agcttcctta 1376041 cctgcagctt cctaaagaaa tgaacccgtt cctgggatat agagcgattc gtctttgcct 1376101 tgaagagcaa gaaatcttca gaacacagct tcgcgcgctg cttcgtgcaa gtacatacgg 1376161 aaacttgaaa atcatgttcc ctatgattgc gacagttaac gaattcaaag aagcaaaagc 1376221 gatccttctt gaagagaaag aaaagctcgt aaaagcggga caggctgtat ctgacgatat 1376281 tgaagtcgga atgatggttg agattccgtc aactgcagtc atcgctgatc agtttgctaa 1376341 agaggttgat ttcttcagta tcggaacaaa cgatttgatt caatacacaa tggcagctga 1376401 ccgtatgaat gaacgtgtat cttacctgta tcagccatac aacccggcaa tccttcgctt 1376461 aattacactg gtaattgaag cagcacacaa agaaggaaaa tgggttggca tgtgcggaga 1376521 aatggcagga gacgagattg cgattccgat ccttctcggc ttaggcttag atgagttctc 1376581 aatgagcgca acgtctatcc ttccggcaag aacacaaatc agcaaattgt ctaaacaaga 1376641 agctgagtca ttcaaagaga aaatcttatc tatgagcacg acagaagaag ttgtcgcgtt 1376701 cgtaaaagaa acattcaagt aatgtacaaa aaccagacgg cctccggcct gtctggtttt 1376761 tttcataagt aagggtatag aaggacacaa taacatggct aggagggata gtatgtcaaa 1376821 ccaatttaac gcaggagata ctgtttatgt gatctacaga aatccgcacg ccgccaatgt 1376881 agcccacata aaggaagccg aaattgtgca ccatccatac catgaaggcg agctttccct 1376941 gtttatttat gaaacctatc atccattcgc agaggacgat gctgtgtttg caagctatga 1377001 agaagctaaa tcgctttaca aagaactgtt tgatattgat ccgtatgagt aacaaggaaa 1377061 tcattacaac tcatatcctt tccgcctagt gagaaaagta acgttagtaa aggaaaagga 1377121 tgtggcatca tgcagaaccc atttgttccg cagcttgtgt atatagaacc gagggcgctg 1377181 gaatatccgc tgggccaaga attacaagat aaatttgaga atatgggtat tgaaatcaga 1377241 gaaacgacat cccacaatca ggtgcgtaat atccctggga aaaatcatct tcagcaatat 1377301 cgcaatgcga aatcaacttt agttatcggt gtccggaaaa cattaaagtt tgattcatcc 1377361 aaaccctcgg ccgaatatgc cattccgttt gcaacaggct gcatggggca ttgtcattac 1377421 tgctacctgc aaacaaccat gggatcaaag ccgtatatca gaacttatgt aaacgtcgaa 1377481 gagattttag atcaggcaga taagtatatg aaggagcgcg caccagagtt cacaaggttc 1377541 gaagcatcat gtacgtcaga cattgtagga attgatcatc tgacacacac gctgaagcgc 1377601 gccattgaac attttggcca aagtgatctc ggaaagctcc gatttgtaac gaaatttcat 1377661 catgtcgatc acctattaga cgcaaagcat aacgggaaaa cgagattcag attcagtatt 1377721 aatgccgact atgtgattaa aaactttgag ccgggaactt cacctcttga taagcggata 1377781 gaagcggcag taaaagttgc aaaagcaggc tacccgctag gctttattgt tgctccgatt 1377841 tatattcatg aaggctggga agaaggatac agacatctgt ttgaaaagct agatgctgct 1377901 ttgccgcagg acgttagaca tgacattacg tttgaattaa ttcaacaccg ttttacaaaa 1377961 ccggccaaac gagtgataga gaaaaattat ccgaagacga agctcgaatt agatgaagaa 1378021 aagcgccgtt ataaatgggg ccgttacggg atcggaaaat atatttatca gaaagatgaa 1378081 gagcatgcac ttcgagaggc acttgaatcc tatattgata cctttttccc taacgcaaaa 1378141 attgaatatt tcacttaaac gggctgttgt gatcaacagc tcgctttttt ataaaaaaca 1378201 tttttccatt ccatcaaaac gccgtaattc aatgattctt tatcctccaa ataattgctg 1378261 actacacgaa taggtgaacg cccgcaacgg aggagaaagg acagcacagg gtcgtttttc 1378321 ctgccttcca tcacatcttc aacgtactga acagcgctga tctcgtgtgc gtatttataa 1378381 tacaaaggaa tgcggccgcc gccgagaagg cgttccagtc ttttatcaac agtcagctca 1378441 tacatcgtat tcatcagcca ttttccgatt ccaagctttc gataatgagg agaaacagaa 1378501 atatccacta catataaagt atttccatga ggttcatgat ttttaatcga tccgttgtca 1378561 gttgcttgtg cccatgtatg atcaggagaa tcaggctcaa attgtacaat aagagcagtc 1378621 atggaaccga taattctgcc attgatgagc gcgcataaag cgccttccgg aaaggttttg 1378681 atatggctgg caagctggtc ctctgaccac agcaattcct ggggaaacgg aggagggaaa 1378741 cattcttctt gaagagaaat cagcctctcg atgtcagtct cagtgtagtt tctaatggtc 1378801 agagcctcaa attttctgcc gtcatgcaca tacatttgtt ttagtatgat catcactctc 1378861 cttatgttgt ttcattataa cgaagattga attttcagta aatatattcc gattttctta 1378921 taatttattt tttgattatt catttttcaa acgaaagggc cgatatagaa attaggaggg 1378981 gattggtttg tttaaaaaac ttcacatgaa gattgctgtt tttgtttcga ttatgttaat 1379041 catcacagtt gttctcttaa tgctgtcttc ttatttgacg ctaaaaccga tgattacaga 1379101 ggatgggaaa aatacaactc aaaacgtgac gcagtcactt gaacaaaata ttgaattgca 1379161 attaaagagt tatgccattt cgttatcaag attggctaat ggggaattaa cgcatacatt 1379221 tgtaacgaaa ccaagtaaag aagcttctcg gctgtttcac gatgacatta agcaaatcaa 1379281 agacaacgat gattatgttg cgatggctta cataggcacc gcaaaaaaag aaatgtttac 1379341 atatccaaaa gcggatttcg ctgaggatta cgatccaaca tcaagaccat ggtataagct 1379401 tgcagctgaa accccggatc aagttgtttg gacggaacct tataaagatg tcgtgacagg 1379461 agacatgatt gttactgcat cgaaagcgat cttagacagg caaaaagtga taggggttgc 1379521 cagctatgac ttgaaactct ctgctatcca gagtatggtc aataaacaaa aggtgcctta 1379581 caaaggattt gcctttttag ctgatgcgag cggcaatctt ttagcccatc cgtcaaatca 1379641 aggaaaaaat atatcaaagg atcaaacact gcaaaccatc gcatccgaga aaaaagggat 1379701 acaagatgtg aatgggaaaa tggttgtgta ccaaacgatt ggcgagacag gctggaaggt 1379761 cggaacgcaa tttgataccg atcaattaat gtggatttca gataaaatga atcgggccaa 1379821 tctttggata tcattgattg cgcttatcat aacaattatt ctcagctact tcctggccaa 1379881 aacgataacc ggtccgatac agcagctgat cgtaaaaacg aaagctgttt ccgcaggcga 1379941 tttaacagtg cgcgcggaat caaaatctaa ggatgaagtc ggtattttaa caagagattt 1380001 caatctgatg gttgaaaata tgaaggaaat ggttgagcaa gtgagactct cttcagggaa 1380061 agtatctgac acctctgaac aactaacggc tgtggctgcc gaaactaatg aaacaagcgg 1380121 acaaattgca aaagcgattg aagaagtagc cgcaggggca tcggaacagg cttctgaagt 1380181 tgaaaccatt aatgaaaaat cggaaagcct gtcaacgaaa atcaggcaaa tcgctgagga 1380241 ggcaggcgga attaaagaac gctcaaaatc gtccgaggat gcaagctata aaggacttga 1380301 cgcgctcggc cagctgctga tgaaatcaaa cgaagccaat atggaaacga aaaaggttga 1380361 aacgatgctg ctggatttgg aaaatcaaac taagaatatt gaagaagtcg ttacagcgat 1380421 ttcaaacata tctgatcaaa ccaacttgct tgccttaaat gccagtattg aggcagccag 1380481 agccggagaa agcgggcgcg gttttgccgt cgtagccgat gaagtgcgga agttagctga 1380541 gcaatcagcc ctttctacaa agcatatcag cgagactgtg aagcttatcc agcttgagac 1380601 aaaagaggcc tctcacgcga tggttgaggc aagcagaatg aatgatgaac aaaacagtgc 1380661 aattcacgaa actggagagg tattaaatac gataactgca gaaatgcagt cactggtaca 1380721 aggtattgat cacatttacg cggaaattca aagaatgagt gaagaacagc ttgcgatttc 1380781 tgaagccatt caaagcattt cagccatatc acaggaatca gctgccgcag cagaggaagt 1380841 gaacgcatca accgatgaac agcttgtcac ccttgataaa gtcaaacact caacggaaac 1380901 actaaaacat gcaagccaag agcttatgaa cacaattgca aaattcacat tgtaatccaa 1380961 ttacatcccc aaacatcatt tgttttgggg attttttatt ttataagatg aatagatatg 1381021 gtagtctaga aaatgaagga aaaatgataa attttaacta aaatctaaac gaaacatctg 1381081 ggaggaatga ccttgaaaaa aacaattggt tttatcggtc ttggagtaat gggaaaaagc 1381141 atggcatcac atattctcaa tgacggccat cctgtattgg tgtacacccg gacaaaagaa 1381201 aaagcagaaa gcatacttca aaaaggcgcg atctggaaag atacggtcaa agatctttcg 1381261 aaagaagcgg atgttatcat cacaatggtc ggctatccca gtgatgttga agaagtgtat 1381321 ttcggaagca atggaattat tgaaaacgca aaagaaggtg catatcttat tgatatgacg 1381381 acatctaagc cttcgcttgc gaagaagatt gctgaagcgg ccaaagaaaa agcattgttc 1381441 gctttagacg ctcctgtttc cggtggagac atcggtgcac aaaacggaac actcgcgatt 1381501 atggtcggtg gagaaaaaga agcttttgaa gcctgcatgc cgattttctc tttaatggga 1381561 gagaatattc agtatcaagg accggctgga agcggacagc ataccaagat gtgcaatcag 1381621 attgcaattg cagccggtat gatcggtgtt gctgaagcga tggcttatgc ccaaaaatca 1381681 ggcctagagc cggaaaatgt tctgaaaagc atcacaacgg gcgcagccgg aagctggtca 1381741 ttgtcaaatc ttgctccccg tatgctgcaa ggcaactttg aaccgggatt ttatgtgaag 1381801 cattttatta aggatatggg aattgcacta gaggaagcag aattaatggg ggaagaaatg 1381861 ccaggcttgt cgctcgcaaa atctttatat gacaagctag ctgctcaagg tgaagaaaac 1381921 agcggaacac agagtatata taagctttgg gtgaaataaa aaaagattgc ctgtacgaaa 1381981 caggcaatct ttttttatta ttttccgatg aattgttgtg tccagatgct tccagactca 1382041 acgtaaccaa caccgatgtg agtaaagtta gggtttagaa tgttttttct gtgtccttca 1382101 ctgttcatcc aagcttttac tacttcttct ggtgtctttt ggcccttcgc aatgttttca 1382161 cctgctgttt tgtagctgat tccgaaagat ttcatcatat caaacggtga gccgtatgtt 1382221 gggctttggt gatcaaagta gtttttgtct ttcatatcct gagattttgc gcgtgcagat 1382281 ttgcttaacg tttcatcaat ttgaagcggt tttaagcctt gtttttgtct ttctgcattt 1382341 gtaagttcaa caactttttt ctcatatgca cttacagatg aaggtgcaga cgttgttgtg 1382401 tttgtttttt cagcagttgc gggtgcttta gaagcagtgt tttgatcagc agctgctttt 1382461 tcagtagtct tttgtgcagg ttttgccgtt tctgtctttt gaacatcctg aactttcacg 1382521 ttagattgct tcgcatgttt ttgaagaagc tgcttcatct ctttttcgtt tgcagcgttt 1382581 aacgttttga tatttgtgtt aatatgcagt tttttcactg catcgttaag tgacatgttt 1382641 tgtactgtgt tccccgtttt tactgtaacc acaggctggc aggagagttc tttcgctgat 1382701 gcttgctgta cgcccccgaa tgtgaataat ccaaccgcag cggcagcaga taaaataaat 1382761 gctttcttca ttagttcgta acctcctaga gttgtttgtt tctacagaaa aatcataaca 1382821 tagctttttt gtcataaaga ttccagcact ttcctttgac aaatagagat tgtcattttc 1382881 gtaaagtaaa tccgttgaat cactaagaat aagggaatca gcggtatata tgattttatc 1382941 gtaccgttac atagcttcct tttttttgaa ccgttagtta tattttaatg tgtttttata 1383001 ttgacagctt tttttactcc ttttcgctgt aacaactatt acaaaggtgt tacaattaat 1383061 ctcagtatat gtaaatatat tgaatgattt gagaggggta accagaagtg actgaaatag 1383121 gacgtgaacc aaagaaaaag agcaaaggaa acagagcaat cagaatgaac ctttttttcc 1383181 tagctgtctt tgttctattc actgcattaa tttttaagct cggggttgtt caaattgttg 1383241 aaggcgaaca gcatgaagaa gacgctgaga aatcaaatgc aaaaacagct tactatcctg 1383301 cgcctcgcgg gaagatgtac gacagaaacc agaaagttgc tgtcgacaac cagagcgttc 1383361 cagaaattgt gtatgtatca acatctagca caaaaacaga agataaaatc aaaacagcga 1383421 agcggcttgc ttctttcatt catattgata ccgaattttt gaaggaaagg gatcttcgtg 1383481 attactggat cgcagctcat ccgaaaaaag ccgccgctct gcttaaggaa tcagaaagca 1383541 atctgaaagg agaccaggct tacaagcttc aaatagagcg tgttccggat caagaattaa 1383601 aggctattca gcaagatgac gaagaaatgg aaactgctgc gatatataca aggttttcaa 1383661 gcggaaatgc ttacgaacct caaatcgtaa aggcaatgaa tccaaataag agcaatagca 1383721 atggaaaaaa cggagcgctg cttgatgaga agaaaaactc ctcgcaaaga ccaaaaaatg 1383781 acttaacata tgatgaaatt tccattgttt ctgagcattt agaagaactt ccgggaatcg 1383841 atatcgtaaa cgattggaca cgaaaatatc cttatgacaa aaccctttat tctgttttcg 1383901 ggggcgtcac gacacctgat cagggcctgc tgagcgaccg gaaagatttc tacttaacaa 1383961 gaggctatgc gaataatgac agggtgggaa aaagttattt agagtatcaa tatgaagaat 1384021 atttaaattc gcataaagaa aaagtggaat acgtagaaga taataaagga aatgtcgtca 1384081 gccaaaaaac cattgataag ggcagcaggg gatacgatct tcagctttct tttgacatgg 1384141 agcttcaggc aaaggtagaa aagatcattg aagaagaagt aagaaacagc cgtgcacgcg 1384201 gaaattacat gcttgacaga gcctttgccg taatgatgga cccgaataac ggcgatattt 1384261 tatcaatggc agggaaaaag atagatttaa aaaccaacaa aattgaagat tatgcgatag 1384321 gggcatttac cacccaatat gaaatgggat cagcagtaaa gggggccacc gtgctagccg 1384381 gctatcagga cgggatcccg cattataaat attatatcga tgctccaatg cttttaggaa 1384441 cgaatcttat aaaaaaatct tatactaata tgggaaccat caatgaatta accgcattgc 1384501 aaaaaagttc aaacgtatat atgttcaatg ttgccatgca tattgcaggc gtaacataca 1384561 agccgcatgg atctctcccg gctgatcaga acgatctact gaaaatgaga aactattaca 1384621 gccagtttgg tctgggagta aagacaggta ttgatctccc gcaggaatca gccggaatgc 1384681 aaaccacacc taaaactgta ggaggattaa ttttagactt agcaattggc caatacgata 1384741 catacacacc gcttcaaatg gctcaataca tctcagtaat cgccaatggt ggctatcgtg 1384801 ttcagcctag aatcgtcaca agtattcata agccaggaaa aaaagaccag ctgggtaagg 1384861 cgattgaaca taggaaacct aaagtactca ataagattaa taattcagag agcgatttga 1384921 aacaagtaca aacaggcatg aaattagtca cttcttcagg gacagcaaaa aatacgttta 1384981 cagaagatgt atcagggaaa acgggaacag cggaaacatt ttactacggc acgaatcgca 1385041 actggtgggg gaaaaaaaca tacaatctga cttttgtcgg ctattacccg tcgaaaaaac 1385101 caaaagtggc ctttagtgtt gttgttccat cagtagatga tgatgataag atcaataaaa 1385161 ttattgccaa aagagctatc cacgcctacg cagagctcga aaaaaaacac agtaaaaaat 1385221 aaaaaacagg gtgcacaact aaaagattgt gtgccctttc ttttattcaa aaattgacgt 1385281 tcaccataag aatagaagga gaatactcat tttctagcga atcatactag gtaaaagtca 1385341 atctgtatat gtcgaaacac gatgatcatg caaaggaggg attctgtgga acaggatacg 1385401 cagcatgtta aaccacttca aacaaaaacc gatattcatg cagtcttggc ctctaatgga 1385461 cgcatcattt atatatctgc caactccaaa ctgcatttgg gctatctcca aggagagatg 1385521 atcggatcat tcctcaaaac gtttctgcat gaggaagacc aatttttggt tgaaagctat 1385581 ttttataatg aacatcatct gatgccgtgc acctttcgtt ttattaaaaa agatcatacg 1385641 attgtgtggg tggaggctgc ggtagaaatt gttacgacaa gagctgagcg gacagaacgg 1385701 gaaatcattt tgaaaatgaa ggttcttgaa gaagaaacag gccatcaatc cctaaactgc 1385761 gaaaaacatg aaatcgaacc tgcaagcccg gaatcgacta catatataac ggatgattat 1385821 gaacggttgg ttgaaaatct cccgagtccg ctatgcatca gtgtcaaagg caagatcgtc 1385881 tatgtaaaca gcgcgatgct ttcaatgctg ggagccaaaa gcaaggatgc tattattggt 1385941 aaatcgtcct atgaatttat tgaagaagaa tatcatgata tcgtgaaaaa caggattata 1386001 cgaatgcaaa aaggaatgga agtcggaatg attgaacaga cgtggaaaag gcttgatggc 1386061 acacctgttc atttagaagt gaaagcatcc ccgaccgtct acaaaaacca gcaggctgag 1386121 ctgctgctgc tgatcgatat ctcttcaagg aaaaaattcc aaaccatcct gcaaaaaagc 1386181 cgtgaacgat atcagctgct gattcaaaat tccattgata ccattgcggt gattcacaat 1386241 ggaaaatggg tatttatgaa tgaatcggga atttccctgt ttgaagcggc tacatatgag 1386301 gatttaattg gcaaaaacat atacgatcag ctgcatcctt gcgatcacga ggatgtaaaa 1386361 gagagaatcc aaaacattgc cgagcaaaaa acagaatctg aaattgtcaa gcaatcctgg 1386421 ttcacctttc agaacagggt catctatacg gagatggtct gcattccgac gacctttttt 1386481 ggtgaagcgg ccgtccaggt cattcttcgg gacatctcag agagaaaaca aacagaagaa 1386541 ttgatgctga aatcggaaaa attatcaatc gcagggcagc tcgcggcggg aatcgcccat 1386601 gagatccgca accctcttac agcgatcaaa ggatttttac agctgatgaa accgacaatg 1386661 gaaggcaacg aacattactt tgatattgtg ttttctgaac tcagccgtat cgaattaata 1386721 ctcagtgaac tgctcatgct ggcgaaacct cagcaaaatg ctgtcaaaga atatttgaac 1386781 ttgaaaaaat taattggtga ggtttcagcc ctgttagaaa cgcaggcgaa tttaaatggc 1386841 atttttatca gaacaagtta tgaaaaagac agcatttata taaacgggga tcaaaaccaa 1386901 ttaaagcagg tattcattaa tttaatcaaa aatgcagttg aatcaatgcc tgatggggga 1386961 acagtagaca ttatcataac cgaagatgag cattctgttc atgttactgt caaagacgaa 1387021 ggggaaggta tacctgaaaa ggtactaaac cggattggag agccattttt aacaacaaaa 1387081 gaaaaaggta cggggcttgg attaatggtg acatttaata tcattgaaaa ccatcaggga 1387141 gttatacatg tggacagcca tcctgaaaaa ggcacagcgt ttaaaatttc atttccaaaa 1387201 aaataaaaac aacggcttaa acgccgttgt ttatcgtctg cattgcttca cgttttttta 1387261 atacaaataa ttctaaacgg tctaggcctt ctctcagcgt gtccattgag catgcaaaag 1387321 acagccttac atatccttca ccatatgttg agaacgagct gcccggcacg agtgccacgc 1387381 cagcgtcttc caaaagagcc atactaaaat caaatgaagt cattccaaat gatttaatag 1387441 aagggaagat ataaaacgca ccggacggtt taactacgtc aagtcccatg gaaacaagac 1387501 ggtcataaac atagtccaga cgttttttgt attgttctct cataatcaat gcatcgtcaa 1387561 agccgtttgt gacagcttca agcgcggctt tttgagaaat ggatgaggcg cacgacacat 1387621 tgtattgatg aacctttaaa atgtgctttg caatgtcttt cggtgcaaat aaaaatccaa 1387681 ttctccaacc ggtcatgctg tgtgattttg acaacccgtt aatgacaatc gtttgatccc 1387741 gcaaataggt tgcgatggag taatgcggtc tgtcatatgt taattcactg tatatttcat 1387801 cagacaatac gaagacattt ctgcctttta agagagctgc gatgcttttc agttcttctt 1387861 cagataaagt cacgccggta gggtttgacg gataaggaag cacgacacac ttggtgttgg 1387921 gtgtcagagc atcttcaatc agccgggcgg taagcttaaa gccgtgtgac gtagtatcaa 1387981 caatgacagg cttggccccg cacaaattga taataggttc atagcccgga taaataggcc 1388041 ctggcataat gacttcatca ccgggagata aaatcgtccg gaatgcagca tcaatggctt 1388101 ggcttgcgcc tgttgtgatg ataatttcag attcagcatc atagttgaaa tccgcttttt 1388161 tcttcatata aagctgcaca gcttgtctca gctccaggta gccggcattc ggagtatatg 1388221 acgtcacgtt ttcatcaatg gctttttttg cggcagcttt cacatgatgc ggtgtgaaaa 1388281 aatcaggctg gccgattgta agtgaaatga cgtcttcgtg ttgggctaca agattcgaga 1388341 atttgcgtat tcctgaaatt tcgatctctc ttgctttcgg attcagcaaa tgttccataa 1388401 ttcatcacct taacaaatat aatgagttta tcctatttta ccactagctg atcatttgtc 1388461 acctttttaa ctgatatatt tcgattgtat gcgccttttt tctaaacata cctttctttt 1388521 cagaaaaaaa gaagacaacc agcgatttga ttgtctttat tgtatcatgt tctattattg 1388581 tttatatgtg ccaatttcat taatagccat aatcaaaatg aaggtcttcg tgccaaatca 1388641 gatacggagg atgctcttct tgaaggtcag ctgattcttt cttcatattc aggtaagttt 1388701 cttcactgat atcctctaaa acagtcattt cgttttcttt aaatattact aaggtaccca 1388761 ttatttacac ccttctttgg aaaaatcctt gactatttta tcactgttag ttggaaagtc 1388821 aatggttatt aggaaaaaag tttctttttt gaggaacgcg gcttgttgcc ttcggaattc 1388881 gattttgaag agctgccatt cactttttac aaattacgcc gatatataca gtacaatact 1388941 gaatgcgaat agcgagggat tgaattgtcg ttacaacaat acgaaatttt attggattct 1389001 ggtacaaatg aattagaaat tgtgaagttt ggcgtgggtg aaaatgcttt cggaattaac 1389061 gtcatgaagg taagagaaat tattcagcct gtcgaggtga catcagtgcc tcactcccat 1389121 cagcatgtag aaggaatgat taaactcaga ggagaaatcc tccctgtgat cagtctcttc 1389181 tcattttttg gagtagagcc tgaaggatca aaagatgaga aatatatcgt gactgaattt 1389241 aataaacgga aaattgtttt tcatgtcggc tctgtttctc aaattcacag agtatcctgg 1389301 gaagcgattg aaaagccgac atcgttaaat caaggaatgg agcggcacct taccggtatt 1389361 attaagctcg aagacctgat gatctttttg cctgactatg aaaaaattat ttatgacatt 1389421 gaatcagatt caggtgttga cacgtataat atgcataccg agggcttcga tgaaagaaga 1389481 actgataaaa agcttatcat tgtagaggac tcaccgcttt tgatgcgcct cttgcaggat 1389541 gaattaaaag aagcagggta caacaatatc gcttcgtttg aaaatggaaa agaggcatat 1389601 gaatacatta tgaaccttgc tgaaaacgaa actgatttat caaaacagat tgatatgatc 1389661 atcactgata ttgaaatgcc aaaaatggac ggacacaggc tcacaaagct gctgaaggaa 1389721 aatccgaaaa gctcagatgt gccggttatg attttctcat cgttaattac ggatgatctg 1389781 cgtcaccgcg gcgaagttgt aggcgcagat gagcaaatca gcaagcctga gatcagtgat 1389841 ttgattaaaa aagtggatac gtatgttatt gaataaataa aaacagccgt tgccagaaag 1389901 aggcacggct gtttttattt taaaagtaac tctcgccaag ttttttaaag accggtttat 1389961 ggtaagctgg ctgctggcga tttggcacta gcggcttttc tttcatgccg acatattctt 1390021 gcaataggtg tttcgctttt gttaaagaca tttgagcttt aggatttcga tacgattgat 1390081 taagtgtacc taaatgcgga agatgttcga agtcttcttt agttggaggc atgtgaaaat 1390141 agtagtctcc gattgagata agcacgtccg attgctgttg gctgaacctt ggattttttg 1390201 aaaaatgaag ccctattttc tttcctttac cttctttgac aagcttttgc aaagcccgtt 1390261 ttttcagcag atataggtat ttagggttgg gggcggtttt tgcatggcgg ttcacagtgt 1390321 aaactgcttt tgaaagattt tctacggttg gctgcagatc tttcgtatat gcatggtcgt 1390381 ccattatttc tctcctttgc tcttatcaat ttctatatgt ttagattata cttttttaaa 1390441 gttgaaatgc aaatattgaa tgtaaaaatg cgcttttttc taagaaaaaa agcgcatttt 1390501 taacctgcat tatacagatc ttgccttctt tttcggctgt tcttgaaatg cttcctgaac 1390561 attcacttcc acagcctgag cactgtattt tggcagtgca ataaaataaa aaataaaaac 1390621 gagcaggata ataacaccca tgccgtaata aagataatca atgtttgaaa caaacttagg 1390681 gaataacagc gcgactaagc cgagtgtcaa agattgtgca aacatcataa aagggtcctg 1390741 catgccgctt acacgtccca tcagttttgg atgaacaatt tttggcatcc accctccgat 1390801 tgcaatgttg atcggtccga tacacattcc cagtgcaaaa gctgccgcgt aatacaccca 1390861 taaaatattg gtgtagccga ggacgaagat cagcaaacct gcaatgaaaa tcggtatcga 1390921 cattaaaaag tgcggcttca cttttttaga gatgagcgtg ccgattacgc ttcctgccag 1390981 aagcccaaac ccgagtgcga tcgtaaatac agacgtatgc cactcataac ggtcaggcgc 1391041 caatccatat ttcattgtaa acatcggcaa tacggcgaat cctccattga caaatccaaa 1391101 aatgaagaag ccaaaaataa gagatgccag caatttgttt tttaaaatat agaggatgcc 1391161 ttctctaaag tcatttattg aatccttaac agaagtcttt ctccagctga atgcaccgtt 1391221 tggctgtcgg gcttcttttg gaatccggca gctgcggatc agcagcccgg aaatgataaa 1391281 gctgacaaaa tcaagaataa tggcgccttc aataccgatt gtgttgtaca taaacgcgcc 1391341 tatgccgact ccaaacacca taaaaatgct aaaaagcatc tgattaagcc ctgccgcttt 1391401 cgcataatgc tccttcggca gaatggcttg taccaaactg ttttctgccg gaaagaaaaa 1391461 ctttgttaca gcgcttctga taaataagat acaaaaaaca agaggaatat tgccggtaaa 1391521 taaagtgaaa aaaagcacga cagtcaggcc tgctctgatc caatcacaat tttctgccac 1391581 cttttttcta tcaaaccggt ccgcgacgac tcccacgatc agaaatacaa atatggtcgg 1391641 aagagaatac atcagctccg ccaaggtcgt atatgaaggc tggctgctga atcggtccag 1391701 caaaaaaaaa gcaaaggcca tgttgcctac tgtcgtgccc atttgagaag cgagtgctgc 1391761 gaaaaataga cgaacaaaat tacgattttt aaatatatcc ataaaaacgc tccttaccct 1391821 aaaggtccca ctttatcata ttataaaccg cctgtttttg aaacaaataa gaaaacatta 1391881 ccggttaatc gtgactctcg ttccgtttgg cacaattgaa gcaagttcga tcacgtcttt 1391941 gttatgcatg cgaatgcagc ctttagaaac agccttacca atcgaagcgg gattattcgt 1392001 cccatgtatt ccgtagtgct gctttgaaag gctcagccaa taagcgccaa atgggccgcc 1392061 gggattgcgc tggcggttaa taatgtaaaa ctcgccagta ggcgtttgcg ttagtatttt 1392121 accaacggcg atgggatagg ttttcattac ccgattattt agggacagcg taagggtctt 1392181 cgctccgatt gagactgcga tatgatacgg aattgtataa gggtccggca gtccggggat 1392241 gactatggac tgtcccgcgg tgagccctgc ctgcagtgac ggattagcct ggagtaatgc 1392301 agccgtgctg attctgaaat cagccgcgat gctgttcagt gtatcacctt gcttcacctg 1392361 gtacgtaagc agtttcctca tcctcctttt ttacttataa gtattgatga ggagcccatc 1392421 ctgctacatt aatttgtgct ttttaaggtg aagacagtga tttcaggctt ggcaagaaac 1392481 cgcaaaggca gcctggtcat cccgaggcct cggtttacgt aaatatgagt gctgcccgtt 1392541 tgatacattc cctctgtgta gacttttcca tatggaggcg taataatcgg tccgtaaaaa 1392601 ggcagctgaa tctggccgcc gtgtgtatgg ccggaaagct gaaggttcac gggataatct 1392661 gttgttttca aggctgcatc aggttcatgg acgagaagaa tggaaaaaag tctgtcgctc 1392721 agccttgaaa gggtgccttc ataatctggg tttcccagca ttaagtcatc aagcgaagca 1392781 atctcgattt tgctgccatc tgcgagtgac aatgtttgat agccattgcg atataccgtg 1392841 aaacctccgg ccgtcatcag gcttttgtaa acggcagttc catagcctcc gtgatcatga 1392901 ttgccgtaaa tacaaagctt gccgaaggga gcattaagct ttctcaataa tggaatgact 1392961 gcctggtggt gctggtacgt atcaggatta tcaataatat cacctgtaaa aacaatgaga 1393021 tcaggtttag attcattaat tgtaagaatg acagttttta aatcttcgag agtaaagtaa 1393081 tcactcaagt gtgcatcgct gaactgcacg attttaaaac cgtcaaatcc gtgcgggatg 1393141 agagagcttt ttattgtgtg ttcggttgtc tcgatcatat gcggctcgag atacctggca 1393201 tagccatatc ccccgccggc cgttaaagcc ccggcagcaa gagcgccgaa cattcctttt 1393261 agaaattgtc ttctggacat ctttttcatt tcaaaccaac ctttaataga gtttttctat 1393321 tatatcatct gtatctgata aaaatctcat atgagcatgt gctgacagag gcagggatat 1393381 aatgatagaa tattattgaa tgaataatca ttcacaattg gagggataaa catggaaaaa 1393441 aaggcggtaa ttattaccgg cgggtcaagc ggcatgggaa aagcgatggc aaaaaaacag 1393501 gctgaattag ggtggcacgt tatggtgaca gggaggaacc atgaggcact tgaggaaaca 1393561 aaaaaagaaa ttcagacctt tgagggacag gtcgcttgtt ttcaaatgga tgtccgttcc 1393621 gattccgccg cttcagacat gattaaagaa gcggtaaaag cctttggccg gcttgacgcg 1393681 ctgattaaca acgcggccgg aaactttatt tgtccggcag aaaagctgac gcccaatgga 1393741 tggaaagccg ttattgagat tgttttaaac ggcacatttt tttgcagcca agcagcggca 1393801 aggcattgga ttgaccagaa gcagcagggt gtcattttaa atatggcagc cacgtacgct 1393861 tggggagcgg gagcgggggt cgttcattcc gctgcagcca aagcgggggt attgtcattg 1393921 acaagaacgc tggccgttga atgggggagc aaatacggca ttcgtacaaa cgcgatagcc 1393981 cccggaccga ttgaacgaac aggcggtgcg gagaagctat ttgaatcgga aaaagcgatg 1394041 gcccgcacga tgaacagtgt gccgctcggc cgattgggca caccggagga aatcgccgct 1394101 ttggcagcgt ttttgctttc tgatgaagca tcctatataa acggggattg tatcacaatg 1394161 gacggggggc aatggctgaa tccttatccg ttttaatctg aatatttata agtgaatatt 1394221 taagttatta agaactttta tgttcgaatg taatacctcc acaattaacc ttcttcctat 1394281 ccaatttgat aacacataga gctttatttg tttatgaggt gttgtgtcat acgtaagcca 1394341 cctaatatat gaaaggtata ttttaaaagg ggagacgaaa tatgaagaac ttagatttca 1394401 aataaaacat tcatataatt acttcgttaa ctaaaaagag aaattataag aatgaaaggt 1394461 ttcaaggtta catcagattg ggaggaaggt aatataatgg acgagatggt attattaact 1394521 caggaatggc tcaatgaaac gtacaaagga aaaagtggct acaattccat tgaggaaaat 1394581 gggaaaactg gctggaaaac aatgtatgca ttaactagag cattacaact agaattggga 1394641 attacacaga cttccgacag ttttggtcct acaactttaa gaaagcttaa agaattaggc 1394701 ccgatttcta cgtcaactaa ttcaaaaaaa aatattgtga aaattattca aggtgctctt 1394761 tattgtaaag gttatggtcc aggtggatta acgggtacat ttggtcaggg aacgaaagag 1394821 gcgatagcag aaatgcaatt gcatatgggg ctttctaaaa cagacggtgt agtaacgcct 1394881 aaggtgttta aagctttatt aaacatggac tcttatatcc ttttaaatgg ggcgtcagag 1394941 aaagttcgtt caatacagca atggctaaat aataaatatt acaatagaga gaatttctac 1395001 tttatgccct gtgatggcct gtattcaagg gatactcaaa agtctcttgt ttatgcaata 1395061 cagtacgagg aagggttaag tgatagtata gctaatggga attttggacc aactactcaa 1395121 agattgattc ctgtattaag aattggagaa acagatgaaa aaaacagttt tattcattta 1395181 tttcaagctg ctctaatctt taatggctac aatgttcctt ttgatggagt atactctgaa 1395241 tctgtaagat caaaagtaaa ggcttttcag tcttttgcaa aattacaaca gagtggtact 1395301 gccgactttc aaacatgggc ttcacttcta gtaagtactg gagaccccaa tcgaaaagga 1395361 gttgcttgtg actcaattac tcaaattaca tcggacaggg cggagtccct taagagggca 1395421 ggttataaga ttgtagggcg gtatctaaca aatgcgccgg ggagtacact aaataaaaaa 1395481 atacaaccag gtgaattaga aactatctta aaatcaggtt taaatgtttt tccgatttat 1395541 caaacctatg ggggagcaac aaattatttt aataaagaac aaggaaagaa agatgcgttt 1395601 gctgcttata aagcagcaaa agaatacggg tttaaaaata acactgtaat atactttgca 1395661 gtagattatg atgcatatgg taacgattta aacaacaata ttattccaca cttcgaaggt 1395721 ataaatgaaa taatgaacgg ttttttaggt tcaacttaca aaattggtat ttatgcccct 1395781 aggaatgtat gtactatagt ttctaaaaaa ggtttagcat ttgcaagttt tgtaagtggt 1395841 atgtctactg gctttagcgg aaacttagga tatcctttgc cttacaattg ggcgtttgac 1395901 caaatttcaa caattactgt tggaaatggt tctggaatga ttgaaattga taatgatatt 1395961 tgttcaggtt tggataatgg agttaatacc ataaatatag tgccttcaga gaataagaag 1396021 ttttttgatc aaattgatgt tttatatgaa actgctgaaa aatatgctca aatgcaaagc 1396081 gacttaaata atggggtaaa aaaaacacaa ttagctaatg agttggttgc ccagtattta 1396141 agaaaggatg actacaaagg gtggaagtgg gtccctaccg caggccagat tgatcctatt 1396201 tatcgtgaat gggcagtaaa gcgctagggg aagacctagt aaatggaatt gttgatccta 1396261 tatcaaaaac tgtcatagga acgcagcatc ttatggcaac ttataatgcc attatttata 1396321 gtggtggtta ctctcaaaca ctacgagatt ttgctggttg gactggagat ctattaacaa 1396381 caatacagga catgaaatta cacgctcaag aatttaattc gccttatgat gcggctatga 1396441 aaataatagg taatatgtat caatttagcc tagatgattt atttagtgat gtagatgcaa 1396501 ttaatctagc gaataaaaca tcagttggtg ctaatgcaca acctctaaat atcgcaatta 1396561 gagattatta tagtaataat gactgtatga ataggttcac tcaatttgta aataatagat 1396621 ttgatggttc gttagacaaa attttctctg aagcagagta ttatttaaat acaaaccttg 1396681 acccagttgt tgttccaatt aggttagcct ttaaacgtgc ttttgatgtt gaggattata 1396741 gtgaagagat tggaaaaata acagcacaag catttagaga tgttatcgag aaaaaaatga 1396801 tatctgaata aactgcaaaa caagcgaacg ttaaaactgg tcgttcgctt gttttatttt 1396861 ctatttaaat ttatgatata atttttaaag attaaggagt gattcattga agaaattgtt 1396921 aaaaaagtta gttgtattat ttttaagcag tttagttatc atctttaatg tttggtactt 1396981 tattatttgt gctttttccc cagagtatta tcaaaataca aatcttactt ctaatgaaat 1397041 aataagattt gaaaaactat accacataga ttttcctgat gaaacaaaat ttattaaagc 1397101 tagagagtat ttggctgggc ccggaggaga tacgtcagct gtattatatg tgtctctgcc 1397161 aaccaagcgg gtagaaaaag ttttatctga ttacacgtat atgaaaataa actatactga 1397221 caatgtcggt tcaatgtatg gagttgacgt ttcaaagagt gtcgccggtt taacaactct 1397281 tacatttggc acttacgata aaaaaggaac tttctataat atgaaacatg atgatgattg 1397341 gatgtataaa ggcactgact ggaatcttta cttttggaca gctgctagtt ataatgctgt 1397401 tatttttgta tttgttttgg ttattgtgaa acaaatgaat aaaattctta attaaccagt 1397461 atgtagattg ataatctcaa aaaaattttc ctcttctttt aacatactcc atacgaccta 1397521 cttttccata ctatgatttt tttgaaattt gtggtgtagt tataattgtg cgtataatca 1397581 gacaaagata gagaagcagg tgataacatg ttggatccac ttgatatttt aacgaacatt 1397641 gatgatgtcc ttccatatta ccaggcgatt tttagtgccg aggagcagaa ggttgtcgga 1397701 tatgaggtgc ttggacgaat tttggcagat tcagaaatcc aaagtctcgg gcccttcttt 1397761 ttagatgcgg ggatacccga agaatataaa ttagaggttg ataacagaat tatccgccag 1397821 gctcttgacc gctttttaga ggcggattct gatctgctga tttttatgaa tcaggatgcc 1397881 aatctgctga tgctggatca tggtgaaagc tttctggagc ttctgaaaga atatgaagcg 1397941 aagggaatcg aactccaccg ttttgtgctt gaaattacag agcacaattt tgaaggggat 1398001 attgagcagc tctaccatat gcttgcatac tatcgtacat acggaattaa aatcgcagtt 1398061 gacaacatcg gaaaagaaag cagcaacttg gacagaatcg cgctgctctc accagatctg 1398121 ttaaaaatcg atttgcaggc gctgaaagtg tcacagccgt caccgtcata tgagcatgtg 1398181 ctgtacagca tatctttatt agcaagaaaa atcggtgcgg cgctgctgta tgaagacatt 1398241 gaggcgaact tccagcttca gtacgcctgg agaaacggag gccgctattt tcagggctat 1398301 tacttagtgt ctccatctga aacgtttcta gagagagatg tattgaaaca aagacttaaa 1398361 actgaatttc accaatttat cacacatgag aaaaagaaac tggagaccgt ctatgagcac 1398421 tctgaacagt tttacaaacg agtgcatcag gctgtgacct ctttgagaaa aaacaatctg 1398481 tcttctgatg atgactttat taaaaagctg gcggaagagc tgacagattg cagcttcagg 1398541 atttacatgt gtgatgaaga aggcgatcag ctgacgggaa atgtgtttaa gcaagatgga 1398601 gaatggattt atcagccgga atatgcggaa aagaactgga gctggcgccc ttattttctg 1398661 gagaacatta tgagaatgag aaatctcaga aaaggttttt tcagtgatct gtacagtgat 1398721 ttggaaacag gtgaaatgat cagaacgttt tcatatccga tggatgatca gatgtattta 1398781 tttatagact tgccttattc ttatttatat gagcaggacg gactgattta acggctgaaa 1398841 ggccgttttt tttatgaaat gaaaaaaata tcaaaaaacg attgacattg atactgagaa 1398901 tcattatcat ttaattatag agagaagcta ctctctgttc cccaacccct ctatcagatc 1398961 aagatccgaa aaaacttggc gctacccccg ccaagttttt tatttgtcaa agcataggac 1399021 aatccaatga aacaataaac ctaactagtg gtaaacgttt aacacgggga gaaacattga 1399081 gtgccgaaca cccctgacac tgctgcacgg gtgaggagga aaattcgttc tgaaatgatt 1399141 atttcagttc cgttgtttac ctctatccag catgactccc attgattatg gccacgcggg 1399201 acttcaccat aaaattcaaa agaaggtttt gacaaagttg caaaaaggca ttcttaatgc 1399261 tgccaaagat tcgaaaaaaa ttataattat gtgcatgaca ttcaaaaaaa gcctcaaact 1399321 aaagaaaaat agtttttttc actttttttc tttgcttaaa ttcagcagtg aaaatgccat 1399381 cctgtccgac tttatggtat gatgctcaat agaacttgta ttataataaa tacttgttga 1399441 tttgaagttg ctttttgaaa ggagtctttt tttagaatgt cacaattaat gggtatcatc 1399501 acacggctgc aaagtctgca agaaacagcg gaagcggcta acgagccaat gcagcgttat 1399561 ttcgaagtga atggtgagaa aatatgcagt gttaaatatt tcgaaaaaaa tcaaacgttt 1399621 gaactgacgg ttttccaaaa gggtgaaaaa cctaacacat atccgtttga taatatcgac 1399681 atggtttcca tcgaaatctt tgaacttctt cagtaagatt cctgaaatag ggggaacaag 1399741 cttccgcctt tgcaaaagta atcgaaataa acggtaagga acatacttgt ttcatggttg 1399801 taaatccttg aaaaggagtg tcgtgatggc tgattctttt ctgttttata atctttcaga 1399861 agcacagatg acctttcaag atgtgatgga acggcttaaa gcctttgttc aaaaggaccc 1399921 ccgttcttct tatgtgttat cgatcggaac cgattcacag gtttaccgcg attacacaaa 1399981 gtttattacc gcattgcatt tgcatcgtac aggcaaggga gcttggggct gcttgaaaaa 1400041 tcatacagtc gacagaccca tacatagcct tcgggagaag atttcgttag aaacggcgta 1400101 cagccaagaa acggccgctc atattcttga tggacactta atggatatta ccgatctgct 1400161 cctgcccttt accggtgagg gggcggatct tacctttgaa gttcacttgg atattgggaa 1400221 aaaagggctt acaaaagatc tgatccaaga aatgactgga cgtattacct ccatggggat 1400281 tgaggccaaa ataaagccgg attcatacac tgccttcagc tatgcaaatc gtttcacaaa 1400341 ataatttggc tgaaaaagcc aaggtaaatg tcgaattatg cggttgacgt ttgttatctg 1400401 attacttatt ctagcggtag agctgaaagt aagttgtctt gctttcagag gtattcagta 1400461 taaaacaggg ggcctgattg cgaatgagtc ttatcggtga acgatttaca gaagaagaac 1400521 aaaaacttct gctgaatatc ctgatcaacc atgagtatgc catcgagcta ttaagcagtg 1400581 agatcaacga tatagagaca gggaccaaaa acgttgacgg aaccacctac aaaaaacttg 1400641 taacgctata cgaccgattt cgatttgaaa attaatggga caccctataa ttgatactcc 1400701 acaaagagta tcttttttat tgaaaggaaa cttttcgaca aatactgata aagtttatat 1400761 tattgcaata tagggaatgt attgatgatg aaaatgaaaa ggggtcgaaa acatgataag 1400821 cttacaatca gatcaacttc ttgaggcaac agtcggacaa tttatgattg aggcggacaa 1400881 agtagcgcac gtgcaagtcg gaaataacct tgagcatgca ttattagtat tgacaaaaac 1400941 cggatacaca gccatcccgg ttctggatcc ttcctaccgt ttacatggct taatcgggac 1401001 aaatatgatc atgaacagta tttttggact tgagcgaatt gagtttgaaa agcttgacca 1401061 aatcactgtt gaggaagtca tgctgaccga cattccgcgc cttcatatca atgatccgat 1401121 tatgaaggga ttcggcatgg tcattaataa cggatttgtc tgtgttgaaa atgacgagca 1401181 ggtatttgaa gggattttta cgagaagagt cgttttaaag gaattgaata agcatatacg 1401241 ctcattgaat aagtaggctg tacggtccta tttttattat ataggcagag tgaaaaaaga 1401301 aagcgcatac ataatttaaa cgagaatagg gcttgaataa gaaactaaga ttttattaga 1401361 atgggagata agaaaaactt attgataaca aaaaggagga cgacatgcag cttcaagagc 1401421 ttcatatgct cgtagtttta gctgaggaat taaatatgag aaaggcggca gaacggcttt 1401481 ttgtatctca gccggcttta tctcagcgct tacaaaccat tgaaaaggcg tggggaacaa 1401541 aaatcttttt aagatctcaa aaaggattaa cggtaacgcc cgccggtgag aaaatcattc 1401601 agtttgcgaa tgatgtgaca ttagagcagg aaagaataag agaaaatatt gacgagcttg 1401661 aaggtgaaat tcacggcaca ttgaagcttg ccgtcgcctc cataatcggt cagcattggc 1401721 tccctaaagt cctgaagacg tatgtggaaa agtatccgaa tgcaaagatc tcgctcataa 1401781 ccgggtggag cagcgaaatg ctgaaaagct tgtatgagga tcaggttcat atcggcatta 1401841 taagaggcaa ccctgagtgg aaggggcgca aagattactt aatgacagat catctgtatt 1401901 tagtggatac tgaaatttcc tgcatcgaag atattgccca tacagaacgt ccgtttatcc 1401961 agtttaaaag tgacagcact tattttcagg aaattcagca ctggtggcat caaaaattta 1402021 aaacgtcgcc gaaacagacg atattggttg atcagattga aacgtgcaaa cagatggcgc 1402081 tgcacggaat cggttatgcc attttgccgt ctgttaccct tcaaaatgaa gataaagtga 1402141 ataaaatgcc tcttttagac atgaaagggc atccgatcgg tcgggataca tggttattag 1402201 gttatgagcc tgcctttgaa ctgaaacaag ttcaagcttt tgtacaagtg ataaaggata 1402261 tgctggatca ggaaaatcca ttttaaagac agcgaggtgc tgtctttttt ttatttatct 1402321 gttgacaatg aaaatcatta tcatttaaag tgatacatat gatattgaaa atcattatca 1402381 actaatgggg tgataacatg gctaaagcct tgattacata tgccagcatg tcaggaaata 1402441 cagaagacat tgccttcata ataaaagata cgcttcagga atatgagttg gatatcgatt 1402501 gtgtcgagat aaatgatatg gatgcgtctt gtttaacctc ctatgattat gtactgattg 1402561 gcacctatac atggggggac ggcgatttgc cctacgaagc ggaggatttt ttcgaagagg 1402621 tcaaacagat tcagcttaat ggtttaaaaa cagcctgctt cgggtctggc gattattctt 1402681 atccaaagtt ttgcgaagcg gtgaatttgt tcaatgtcat gctgcaagag gcgggagctg 1402741 ctgtttacca ggaaacacta aaaattgaat tagcgcctga aacagatgaa gatgtggaaa 1402801 gctgccgagc gtttgcgaga ggttttcttg catgggcaga ttatatgaac aaggaaaaaa 1402861 tccatgtttc ataaaggggc aaccgctgtt acggcatcgg cgttttctgg atattttgtg 1402921 gcggtacaaa gagaaggcat ttttcattac tctttggagc agggctggag aaagcttttt 1402981 cgtttgaaaa gtaagataca ctgtatcagc tacatagggc cttacttatt tggcgttggt 1403041 gaaaagggaa cagtcattcg ttcggctgat gaagggaaaa cctggacgat gtcgagcttt 1403101 ccgacaaatg caacagtgtg ggcgattacc ggcagaaaca acgggtttgt ctgcgcccac 1403161 ggtaagcatt gtatttatgt atcggatgat tttggtgtct catggcgcgt agccaaacct 1403221 tttgccgaat ttcataatcc ccctgttatc cggtcgttat gccttcacgg gggcaatctc 1403281 tttatcggca cgcaaataca cgaatatttt ggcggcattt gggcttacga cattaagcgt 1403341 gacactgtcc aagttgtcaa aaaagaaaaa aaccggatga cggcatccat gctcgtgttc 1403401 aatgaaaatt ggctggtggc ggcgatgggt tctgtgaaag gaaagcacgg tgctgtcact 1403461 gtaaggaatc ttttgaatgg tgaagaattc accatacaat ccagtatgat cagaaatgaa 1403521 gaatcatttc ttgatctttc agaggatgat ggcattatat atgtcactac aacacaagat 1403581 gaaaatggtt tttcgagaat ttaccaggtt gatctcgaag cccggtcgtt aaaatggttc 1403641 gataccatta agggacatgg atggagagtg gccaatcaga aagagaattt cttttgcgca 1403701 ggcttgtatg aatgtaaatt tgtccagccg tacgaagttt cagcaatgat tcattagagg 1403761 aggaacaagg aattggcgaa gattttgctc gtttatgcaa caatgtcagg caacactgaa 1403821 gctatggcag atttgattga aaaggggctt caggaggcgt tagcagaagt agaccgtttc 1403881 gaagcaatgg atattgatga tgcccagctg tttaccgatt atgaccatgt cataatggga 1403941 acctacacgt ggggagacgg agatctgcct gatgaatttt tagatcttgt tgaagacatg 1404001 gaggagattg atttttccgg caaaacatgc gctgtattcg gttccggtga tacagcatat 1404061 gaatttttct gcggagcggt tgatacgcta gaggcaaaaa taaaagaacg cggtggagac 1404121 attgtgctgc cttcggtaaa aatcgaaaat aatccagaag gtgaagaaga ggaagaatta 1404181 ataaacttcg ggagacaatt cgcaaagaaa agcgggtgcg ctgtctgatc actcactggg 1404241 aactgctaaa acggctgttc ctttttttct tgtctttgta tctttccttt gatacagtaa 1404301 tgaggtagaa aatcaggagg aggactatac atatgaaaat gatggacgca aatgaaatta 1404361 tttcatttat tcaaaatagt acaaaatcta cacctgtaaa ggtttacgtg aaaggtgagc 1404421 tggaaggaat caatttcggt gaatctgcga aagcttttat caatggaaac actggtgtcg 1404481 ttttcggtga atggagcgaa atccaaacag caatcgaaga aaaccaaagc aaaatcgaag 1404541 actatgtggt tgaaaatgac cgccgcaatt ctgcgatccc aatgcttgat cttaaaaaca 1404601 tcaaagcgcg tatcgagccg ggtgcgatca tccgcgacca agttgaaatc ggtgataacg 1404661 cagtcatcat gatgggtgct tctattaata tcggttcagt catcggcgaa ggcacaatga 1404721 ttgatatgaa cgttgtgctt ggcggacgag ctactgttgg aaaaaactgc catatcggcg 1404781 cgggttctgt acttgcgggc gttattgagc cgccatccgc taaaccggtt gtgattgaag 1404841 acgacgtcgt aatcggcgca aatgctgttg tgcttgaagg tgtaacagta ggtaaaggag 1404901 ctgttgttgc tgcgggagcg atcgtggtaa acgacgttga gccatacact gtcgttgcag 1404961 gcacaccagc taaaaaaatc aaagacattg atgaaaaaac aaaaggcaaa actgaaatca 1405021 agcaggaatt acgccagctg taaggaaaag tttgataaaa aaggcgtgga taatatatcc 1405081 acgccttatt cgtataggca ggaggaatag aaatgaagat agaggagctc atcgcaattc 1405141 gcagagatct gcatcgtata ccggagcttg gatttcagga gttcaaaacc cagcagtatt 1405201 tattaaatgt cttggaacaa tatccgcaag acagaattga aattgagaaa tggcgaacag 1405261 ggctttttgt aaaagtgaac gggacggcgc cggaaaaaat gctggcatac agagcggata 1405321 tcgatgcgct ttctatagaa gagcaaactg gtcttccatt cgcatcagag catcacggca 1405381 acatgcacgc ctgcggtcac gatttgcata tgacaattgc actcggcatt attgatcatt 1405441 ttgttcacca cccagtcaaa catgatttgc tttttctgtt tcagccggca gaggaagggc 1405501 ctggcggtgc ggaaccaatg cttgagagcg atgtattaaa aaaatggcag cctgatttca 1405561 tcactgccct tcatattgct ccagagcttc cggtaggcac cattgcgaca aaaagcggcc 1405621 ttctatttgc gaatacatca gagctagtca tcgatctgga aggcaaaggg ggacatgcgg 1405681 catatccgca tttggctgag gatatggttg tagcagcaag tacacttgtc acccagctgc 1405741 aaacgattat ctctagaaac acagatccgc tagacagtgc tgttattaca gttggtacca 1405801 ttaccggagg ctcggcacaa aatatcattg cagaaacggc ccacctggaa ggcacgatcc 1405861 gcacgctttc tgaagaatcg atgaaacaag taaaggaacg gattgaagat gtagtgaaag 1405921 gaatcgaaat cggattccgc tgcaaaggaa aagtgacata tccgtctgta tatcaccaag 1405981 tttacaatac gagcggatta acagaagaat ttatgtcttt tgttgctgaa catcaactgg 1406041 cgacagtaat tgaagcaaaa gaagcaatga ctggagagga ttttggctat atgctgaaaa 1406101 aatatcccgg attcatgttc tggctcggcg ctgattctga acatgggctt catcatgcta 1406161 agctgaatcc cgatgaaaat gcgatagaaa cagcggttca tgtcatgaca ggttattttt 1406221 ctgtttatgc caattaagta caaatgaaag aataaaattc cataaaatga gcactctagt 1406281 aaacggaggt gttcaaaaat ggctaaaaaa attggaattg aacaatcgtt atcagatgta 1406341 gaagctgctt taaaagaaaa aggatatgac gttgtaatga tgaaaagccc tgctgatgct 1406401 caaggctgtg actgctgtgt cgtaacaggt cttgataata atgtgcaagg gatagccgat 1406461 acggtaacac aagcacctgt cattacagct tccgggatga cggctgaaga aatttgtagc 1406521 gaagttgaga gcagaattca gtaataaaaa aaccgaagca aaaagcttcg gttcttttat 1406581 ttattctgtt tctttaggga aagcgcggtc gaacgcgttc tttatttctt ttctcaacac 1406641 tcgttcgact cgccactgtt ccatattttc tgttttggca atgaccctga ttacaatttc 1406701 agaagtcccc agttcttgaa tcccgatgac atttgggcct tcttttattt gtggaagagc 1406761 cgctgccgtt tcatcacaaa cctgctgtaa aatatgaatc atttcatcaa tatttctttc 1406821 agccggcact ttaatgtcaa caagagcctg catggtacca cgagaatgat tgctcacgtt 1406881 tgtgatgttt ctgttgggga tgtaatgcag tgttccgtca aagctgcgga tttgagttgt 1406941 ccttaagcca acctgctcga caattccgtc aaaggtggaa acggtaatat aatctccgac 1407001 atccaattgt ttctcaagca aaataaaaaa acctgtcacg atatcactga caagcccttg 1407061 ggcgccaaat ccgacagcca ggccgacgat tcctgccccc gctaaaagag cgcttggatc 1407121 ataatgaaac aaatctagaa ccatgacgaa aaatatgaaa atcaatgtat aagcaaatat 1407181 gttaagagtc aggcttcgga gcgtatgtgc acgtccgata gacaagctat tctgctcctc 1407241 gaattttgca aacagatgtt taatgatttt catgcctaat gatcgaacga taaaatagag 1407301 caatatcata atggcgagtt taatgagcag aacaccggca tttgtaatca gtcccgccca 1407361 atcatattgt ttaataaagt ccatgttgag ctccttttct aattgattgc tgcacattga 1407421 gactagttac cctgtacatg accatgttaa acgttttatt caaaaatgtc gaagccaaag 1407481 acatacatga tttgttaaaa attgactcag gaaatctgct tttatataat ggcattgcaa 1407541 tataactaaa aatggttaat caccctttat tttcatgcga ttttgacctt taagccaaac 1407601 aataaattgg agggatacat atggcagaac gtatggtagg taaacaagct cctcgttttg 1407661 aaatggaagc agtccttgca agcaaagaat tcggcaaagt aagtcttgag gaaaacatga 1407721 aaaacgacaa atggacagtg ctgttcttct atccaatgga cttcactttt gtttgtccga 1407781 cagaaattac agcaatgtct gaccgctatg acgagttcga agatcttgat gcagaagtca 1407841 tcggggtttc aactgatacc atccatactc atttagcttg gatcaataca gaccgcaaag 1407901 aaaacggtct tggccagctg aaatacccgc ttgctgctga tacaaaccat gaggtatccc 1407961 gggaatatgg cgttttaatc gaagaagaag gtgtggcttt gcgcggattg tttattatta 1408021 atcctgaagg ggagcttcaa tatcaaactg ttttccataa caacattggg cgtgatgttg 1408081 atgaaacgct tcgtgttctc caggcgctgc aaactggcgg actctgtccg gctaactgga 1408141 aaccaggcca aaaaacactt taattctttc caagaacgaa aagcggtcta gcatattcgt 1408201 taggcctctc ttttaaaata ggagggaaaa agcaatgaaa ttacgtcagc ccatgccgga 1408261 attgacggga gaaaaagctt ggttaaatgg tgaagtgacg agagagcaat tgattgggga 1408321 aaagccgacg cttattcatt tctggtccat cagctgccac ttgtgcaaag aagcgatgcc 1408381 gcaagtgaat gaatttcgtg ataaatatca agatcagctg aatgttgtag ctgtacacat 1408441 gccccgttcc gaagatgatc ttgaccctgg taaaattaaa gaaacagctg ctgaacacga 1408501 tatcactcag ccgatttttg ttgacagtga ccatgcttta accgatgcat ttgaaaatga 1408561 atatgtacct gcatattatg tgtttgataa aacaggacag ctccgtcact tccaagccgg 1408621 cgggagcggt atgaaaatgc ttgaaaaacg tgtgaaccgc gttctggctg aaacggaata 1408681 ggtatctgac taaatagtat ttcctaaaaa cctgacctca tcaggttttt tatttgtgca 1408741 aaaagcaatg gaagaagagt aagaagctta tttttccaaa tttgggtata ggaattgatg 1408801 atttgtttga ttgatacgct aaaaaacaca gctaattttt gatgtttttc ctcaatttta 1408861 gataaatctc atatctcata actcgaaaat tgtagatatt acactaaatt tctttaaaga 1408921 agtaagtaaa atatatattt tcaacattat accaaataaa ctagaaagcc ccttaatccc 1408981 ttgagaataa aggactcttt tgaaaaataa aacattttca gaaaataagg aatttttcat 1409041 agagtaaata taatagtaaa atgctaaaat aatagttgat aaaattactt ttgtaatcta 1409101 atatcttaat taaagatgtt aattttgata gggggtacat tgaggaatgt ttaatgaaag 1409161 agaagctttg cgcttgcggt tagaacaatt aaatgaagct gaagtgaaag tcattcgtga 1409221 atatcaaatt gaacgtgata aaatatacgc aaaattaaga gagctggaca gaaatggaag 1409281 cccttccgaa atcaaaaagg atttccgttc tgaaaaaaaa cctgactctc tgccggttct 1409341 cgctgagctt gcggctcagg aaatcagaag ctatcagccg caatcacagc agcagtctgt 1409401 tcagcctcag cttcaatcta tttcctctct tcctgccggt ataccagacg gaacaacacg 1409461 aagaagaaga ggaacggcaa gaccgggatc aaaagcagct aagctgcgtg aagctgctat 1409521 taaaacatta aaacgccaca acgcggcgat taagagctcg gagcttcaaa aagagattga 1409581 aaaagaaagc ggtcttgaaa tccctaatat gacaacgttt atgcaaagct taattaaaat 1409641 gtacccggaa gtgaaaaagc catatcgcgg gcagtacatt ttagagggtg aaatcgaatc 1409701 tgcagaatca gcaaacgaat aaatataaag aaaaactgct tggcatcgct caagcagttt 1409761 ttttattgag gttttttctg tgaaggtttg ttttcttttt caagattaag cttatacacc 1409821 cacttttgat aaggcttttc ttcagcggct ctgtttttca gctcttcgat tgtatggctc 1409881 ttggcctggt ctgatgattg ggcgtgggca agctgttttt gaagcacatg tatctgtttg 1409941 gtgacatctt caaggatagt ctctacatga tttggctgcg cgtaggccgc tggagcttct 1410001 tcttccgttt tttctttttg tttcgtgccg ccatcaatat cggcaaaatg agaagcaatc 1410061 caggcatcgc tttcatcaag ttgccgttta tacgatataa tagtttcgtg aaataatttt 1410121 tctttcgttt tttctatgtc tagcagtctt tctttcgttt ctatgattcg atctttcata 1410181 tgatcaactt ctattttaat atgttttagc tgatattctt tttctaccat ttgctctttt 1410241 agacgcccgt tttcggcttt tatcaattcg gcttgctgtt ttgcctgaag cagtgcattt 1410301 tgttcctgct caattgaggc ttgaagttcg ctgatccgtt tatgaagatt tttattttct 1410361 tcttcgattt tgactttcgc aatatgaagt ttatgttttt cttcgatttc ggctctgcgt 1410421 ttataggttt cagcagatag aagctcctgc aaaacaacga ttttatcaag cagttcagct 1410481 cttatttggt gcagggtttg gctggtgtgg gaggcatgtt tttcttttgt tgacatatgt 1410541 gttaattcgg cagacagctg ctggagtttt tctttcatat cggtattttc tttgagcagt 1410601 ttgttatttt tctgatgaaa gtagcttgct tcaagttcag aaatcagctt atggcacctt 1410661 gaaagctcgg attttaaata aaggttctcc tgagacacgt cgtggaaaaa aggacctgat 1410721 cttttcattc gaaccatctc cctcatgatg ttaacactac aatatgcaaa tactgaacag 1410781 ctattcctct ttaataaaca gacaagcagt agcgttgagc ctttgctttt gctatgcttt 1410841 taacgaaact agaggtgaga tgatatgaag catgtaaacg tactgctggc agggggagcc 1410901 tcacgtcgct ttggagaacc gaaggcgttt gtcaaatgga agggcaggat gctttacgaa 1410961 tgcgctaaag aggcacttgg agaacaaacg gttatcatca gccgtcccga atttattgat 1411021 agatttcaag aaaacggtga aaatgaagtg tatcaagatg ctgagccatt tcaaggcatg 1411081 gggccattgg ctggtatata taccgctttt aaaaagacag acggtgatct ttatactgtt 1411141 ctttcctgtg acacaccgct gatacaaaga aggacgatgc tggagctcaa acgtctgatg 1411201 attgccggtg cggacgcggt agtcccaatt tcagacggac aagtgcagcc attgattgcg 1411261 atttaccaca aacgtatcat gccagttcta tacgatcagc tttctgagaa gaggttgaga 1411321 atatcagatt tattaggcag aatttcggtt tgttacgtac aggctgaaaa tatcggagca 1411381 aacccggcag agtttatcaa cattaataca cgtgatgatt ttagctgttt ggaagaaaaa 1411441 tcgaactccc tcaagcggga ctgacggggc aataacatga taagatgaca taaaagataa 1411501 ggagaacagg tttgatggag gaacgttatt cacggcaaat cagatttaag caaattgggg 1411561 aagagggcca gaaaagactg gcagacagcc atgtgctgat tgtcggagcg ggagcgctcg 1411621 gcactgcagg agctgaaggg ctttcgagag cgggagtcgg tacgattacc attattgacc 1411681 gtgactatgt ggagtggagc aatcttcaaa ggcagcagct ttatacagaa agcgatgcca 1411741 aactccgcat gccgaaagcc atggctgcca aagagcatct atcagcgatt aacagcgaga 1411801 tacatattga ggcgtatgtt accgaaggaa cagccgaaac gcttgagccg ctgattgaaa 1411861 aagcagatgt cgtgatcgac gcgacagata attttgaaac ccgcatgctg ataaacgatc 1411921 ttgcccagaa aacaaagaca ccttgggtct atggcgcctg tgtaagcagc cagggaatgt 1411981 tcatgactgt cattcccgga gaaacccctt gtctgtcttg tttgtttgag caaattcctg 1412041 tcggcggggc gacgtgtgat actgccggca ttattccgcc tgctgtgcat atcgtttcag 1412101 catatcagca ggctgaggca ttaaagctgt taaccggcca aaaagaagca atacagcggg 1412161 ggtttgtgac atttgatgtc tggaacaatt cgcatatgaa gattaacgtt aatcatgtac 1412221 gccgtgagga atgcccatct tgcggagcta atgcggtata tccttatctt caggattgga 1412281 acacaccaaa agctgctgta ctatgcggcc gtgatacagt gcaggtaagg tcagaatcat 1412341 taaaaagaat cccgaaacag gagctcatta agcggctgaa aacaatcggc aaggtcgagg 1412401 ctaatgcgtt tttgctgcat attttttacg aggatttcag aattgtcatt ttcaatgacg 1412461 gacgggcact ggtgcatgga acaaatgatg tgaaagaagc caactccgtg ttggcaagag 1412521 tgattggact gtaacaacag gaggggtcag aatgctggag aaaagaacac cgataccggt 1412581 agacgaggca gttcggcgtg tctgccattt tcaaaaacaa ggtgaaacag aatgggtggc 1412641 gcttgaagac agccttcatc ggtttttagc cgaagatata actgcggatc accacgtacc 1412701 tgcgtttgac cgttcgccat acgatggttt tgctgtcaga gcgtgcgata cggcagaagc 1412761 ttcacgtgaa aacccagttc ggtttgaagt tattgaccat attggagcgg gagcagtatc 1412821 tgaaaaagaa cttggcccgt ttcaggccgt gcggattatg actggcgcgc aaatccctga 1412881 aggggcagat gcagtcgtca tgattgaact gactcaagcc tttgaggaga atgggaagtc 1412941 atttatgtct ttaaaacgcc gctttcagac gggggataat atttcaaaaa caggtgagga 1413001 cgctcaaaaa gggagtgttt tactgacaaa gggcacccgg gtgacaccag gagtgacggc 1413061 tcttttggca acattcggat acgcatctgt gcctgtcgtg agaaagcctg tagtcgggat 1413121 tatcgcaacc ggtaccgaat tgctgaatgt cagtgatccg ctggaaccgg gaaaaatccg 1413181 caacagcaat gcgagtatgg tatatgcgca agcgatagaa gcaggcgcaa caccgcttta 1413241 tttagggaaa atctctgatg aactggataa aagctttgct gcagttaaag aagcgatgaa 1413301 aaaggtggac ttcctgatca caactggcgg tgtgtcagtc ggtgactttg actttttgcc 1413361 tgcgatctat gaaaaactcg gagcggacgt gctgtttaat aaagttgcca tgcgcccggg 1413421 cagcgtgaca acggtggcgc atgcaaacga tatgctgctg tttggccttt caggtaatcc 1413481 gtcggcatgc tatgtcggtt ttgaactgtt tgtcaaaccg ataatccaga catggctgct 1413541 caatgaaaca ccgcattcaa tttgtgcgga agctgttttg accaaggatt ttccgaagcc 1413601 gaacccattt acccgatttg ttcgtgcgct cgtgcaccat caggaaggga agctgttggc 1413661 gacacccgtt ggcttagata agtcgagctc tgtcacatca cttgcagatg ccaatgcatt 1413721 tattatcctg ccgggcggta cgcgaggcta cgaatctggc agaacggttc aagtgctgct 1413781 catcagagaa gagaatggaa gtgaatggcc ttggtccgtc ctttcccgat cgtccaagtt 1413841 gtaggatttc aaaacagcgg gaaaacaacg tttattgagc gcattcttga aaaagcctct 1413901 gaacagggag tccatttggg ctgcctgaag caccatggtc acggcggtga accgcaaacg 1413961 ctcacggaag gaaaagacac ggaccgttac aaggcggcag gtgctgatgt aacagcggta 1414021 gaaggtgctg gtgtgttaca gctgactgcc cgccgcaatt gggatttggc acggctgatt 1414081 gagttatacc aatttctcga aacagactgt cttctgattg aaggctttaa aaaagcccct 1414141 tatcctaaag tggttatcct aagtgaaaag gaagatctgg aagcgctgca agcagtaaat 1414201 ataatcgcca tcatctatag aaaaaaagag catatgacag agcatcaggg attacccgtt 1414261 tttcatgcgg atgatccggt tgccgtggat tttgtgcttt cacagctgaa gggggaatct 1414321 gcataatgga acggtttgag attacgaaaa cacccattaa tactgaaaac atcatcaaaa 1414381 aagtggagaa acgggaagcg ggagccatta caacatttat tggtacggtt cgggaatgga 1414441 caaacggaaa aagaacggtt cggcttgaat atgaggcata tgaaccgatg gccgtgcaaa 1414501 tgcttgctca aatcggcgct gaaatcgaag aaaaatggga aggtgcctca gctgcgatca 1414561 cgcaccgtat aggtgtgctc gatatcggtg aagcagcggt agtgattgct gtatcttctc 1414621 cccatcgaaa agccgcatat gaagccaatg agtatgcgat tgaacgcatt aaacagattg 1414681 tgccgatttg gaaaaaagaa atttgggaag acggtgagca atggatcggc gaccagctag 1414741 aaacgacagc ttatccgaac ggaaaaccag acctaagcga gggagagcag catgattaaa 1414801 attcttttat ttgcagggct tgctgaacag gccggtacac aagcaataga aatagatatg 1414861 gaacaagcaa ccacagatga aataaaagcg agtctaaaag aacaatacgg tcttgaatct 1414921 attgatacgg ctatgattgc cgttaacgaa agctatgtaa aagaaaatac ctctgtatct 1414981 tcgggtgaca cggtagccat cataccgccg gtcagcgggg gatgaaaacc ggacggcatt 1415041 tcagccgtcc ggtttttctg tatttcattg gcatatcccc aagtatcctc agcatacaat 1415101 gattttctgt aagcgtttat tctacatatg ttactcccta taaagtaaga gactcactcc 1415161 ataattagac tgaaattttg aaaaataata gaaatttatt tcgggtatcg atatagtgaa 1415221 gatgataaat gttggaaagg tgctggatat ggagacattt aaaagattaa aaatgtatta 1415281 ttggccgtac agaaaagtgt ttatgtggtc gcttctagcc atgcttttga tgactgcaat 1415341 tactgtcgtt tatccgatta tcctgcaaat tacgattgat gagatcgtac tgggacggca 1415401 gtatcagctt gcggcgtggg tcagcttagg atttattgcg gtgatggttt tgaaaggaat 1415461 ggctaccttt tttcatcagt atttaggtga tatgttcggg atcaaatccg tttatcggct 1415521 gagaaatggt ctgtatgaaa aactgcagcg gctttctttt tcttactatg ataacgcgaa 1415581 aacaggagat ttgatgtcca ggctgactgc tgatgttgaa gggcttcgtt ttttcttatc 1415641 atacggtctc gctgagctca ttcgcttcgg cctgctggta gccatcagcc tgtcggttat 1415701 gttttactat tctgttcctc tcacgcttgt gacaatagct gttctgccat ttctcgcggt 1415761 tgcggtatac cggtttgaca aaagagtcca tcccgccttc agaggcatcc gcaaatcgtt 1415821 tgcgaaactc aatacaaaag ttcaggaaaa tatcagcggc attaatacgg ttaaatctct 1415881 ttccagggaa gattttcaga tcagcacttt caataaagcc aatgcagaat acagggcgca 1415941 gtatttacaa acatcatcca tttggtctgc gtatttccct ttaatggagt tcattggtaa 1416001 cacttgtatt gtagctcttc tctcatacgg cggttacttg gttatgcaaa atcagctcaa 1416061 tcccggcgag cttgttgctt tcttcagcct tgtcaattat atgatgtggc ccattatgaa 1416121 cttaggtttt gtcatcaata tgttctctca agcaaaagcg tcaggggaac gcctgctcga 1416181 cattctggaa aaagaagaag acattacaga tcatcctcat gctttgcata aacaaaaatt 1416241 aaccggagat gtccatttca aaaatgtttc tcttgcatac ggaaaagaac aaacaaacgc 1416301 gctgtgcaat gtaagctttg aggcaaacag cgggaaggta atcggactgt tgggcccgac 1416361 aggttcaggc aaaagctcag tgacacagct tctcaccaga ttttacagtc ctgttggcgg 1416421 aatgattacc attgatcaca aacccatcac agattattcg ttaaaaaccc ttcgctccaa 1416481 tatcggggtc gtacttcaag aatccttcct gttttcatct acgattagat caaatatttc 1416541 gtatgggcgg ccggatgcct caatggaaga cgtcatcgaa gcggcaaaaa gggcgcaggc 1416601 tcataacttt attatggagc ttcctgatgg gtatgacacc atgctgggag agaggggaat 1416661 ggggctttcc ggcgggcaga aacagcgtat tgccattgcg agagccatct gcttgaaccc 1416721 gagcatttta atattggatg atgccacaag cgcagtagat atgcaaacgg agcacagcat 1416781 acagcttgcc ttaaaagaag tcatgaaaaa ccgcacaacc tttatcgtcg ctcaccgcat 1416841 ttcttcactg aaacacgctg atgaaattct cgtttttaat aaaggacgca ttcgtgaaag 1416901 gggaacacat catgagcttc ttgaaaaagg cggctactat aaaaagattt acgatttgca 1416961 ataccgtgat gtcaaaatga ttaatgagcc gcatgaggtc ggatagggag gggccaaatg 1417021 aaacaagcga aaaaacaggg ggttttagag cgtttctatt actcttcaga tgaaatcatt 1417081 gaaaagccgt ttaactgggc tcaaatgtgg cggctgctga gctatgtcaa accatatcga 1417141 aaaacaattt tgccgctttc ttttctcact gtattgattg gcactgctgt gaagcttgtg 1417201 atccccattt tgatcggcgt ttatgttctt gatcaagcga ttacagggag aaactcggag 1417261 ctgctgattc agctcatttt tattattagc ggtttatatg tcctcaatta cgccgccaat 1417321 gtgttaagaa tcaggtggat gaatcagctt ggccagcatg tcatttacga tttgcgacag 1417381 catttattta cccatgtgca gcgcttatcc catcgatttt ttgatcagcg gtcggcggga 1417441 tcgatcttag tcaggatcat gaatgatatt aactctcttc aggagctctt tacaagcgga 1417501 gtcatcaatt tgttgaccga cttgctgctt ctggccggcg tgattattat tttgtttacg 1417561 ctgagccctg agctgactat agccatcatg gtgacattgc cgattatgtt ttttatttca 1417621 acaagtctca gaaaaaaaat acgccgatcc tggcaaacgg tacggctgaa gcaatcgaag 1417681 ctcaactctc atctaaacga aagcattcag ggcatccggg tcacgcaggc atttacgcag 1417741 gaagaagaaa acatggcgta ttttgacggt gtcaatcagg agaactacga atcatggcgg 1417801 gaagcaacta gaaaaaatgc catgttccgt ccgcttgtag aaatgacgaa tgcgattggg 1417861 acggctgtct tgatttggta tggagccaca ctcatcatga atgaaaccat tacgattggc 1417921 gtcttcgttt cttttgcttt ctatctggga atgttttggg aacctatttc gagactgggt 1417981 caggtctata atcagctgtt aatggggatg gcatcatcag aacggatttt tgagtttctg 1418041 gacgaacagc caaatgtcaa ggagaagccg aatgccattc ataatgaaaa gataaatggg 1418101 gagatcagtt ttgaagaggt tgaattttcg tatgatgaaa aacgaaaagc ccttcacgcc 1418161 gtttctttct ctattcctgc gggatcgacg cttgcgcttg tcgggcatac agggagcggg 1418221 aagacgacga ttgccaattt aatcagccgt ttttatgatg cggccggagg caccattaaa 1418281 atagacggta taccgattaa ggatctttcc cttgccagtc tgcgctctca aatcagcatt 1418341 gtcctgcaag atacatttat tttctccggg accatcatgg aaaatattcg ttttggaagg 1418401 ccaaatgctt cggatgaaga ggtgatgaaa gcgtcccaag cggtcggagc ggatgagttt 1418461 atttccgatt tagcggaagg atacgcaaca gaggtagagg aaaggggcag cgtactgtct 1418521 gccggtcagc gccagctcat ttcatttgca agagcattgc tcgccgatcc ggctattatc 1418581 atccttgacg aagcaacggc aagcattgat acagagacag aagtaaaaat tcagcaagcg 1418641 ttaaaaacgc ttctgaaagg gcgtacagca gtgatgatcg ctcacagatt gtctacgatc 1418701 cgcgacgccg accgcatcat tgttcttgat cacggcagga aaatagaaga agggaaccat 1418761 gatcagctgc tcgctaaagg aggcatttat gccgggcttg tgaaagcgca atacagcaca 1418821 gcgatagaat aatatgaaaa gccttcaata ttgaaggttt ttggaaattt attagaaaaa 1418881 catgaaactt tttgatatcc ttcccgtact atttgttaga tattctcaag gaggttttga 1418941 aatggaaacg aatgtagaaa aaaacagcgg aacggcgact gaaaagcctt cacttttcgg 1419001 agtaatcaca agtccgtccg ttcaatttga aagaataaga gaaaggccgg ctgtatgggg 1419061 accgcttttg attgttgcag caattatcat cgtcggtgcc gtgctgcaat cactcggtac 1419121 ggattatagt gagcttttga aaagccagga tacgcaaggg ctatctgctg aacaaatgga 1419181 aactgtcgca acaataacca aatttggcgg aatggcaggc gctattatcg gcggtatcgc 1419241 agcattattt attgcccctc ttatttattg gctctgtgta aaagtatcag gcggtgttac 1419301 gacatataaa aaaatgcttt ctctcagtct gtttgtctct ttgattagca gtctcggatt 1419361 attggttaat ggaatcgttg cttttacgac tgacgtgaat cctctttaca gcacgacgtc 1419421 actcgcaggg attatcccat ctgacggggc tctcgccagt gtgttaaata cctttgaaat 1419481 tttcagcatc tggagctttg tattattagc aatcggactt cacaaaacgg gaggcatctc 1419541 aaaaaaagcc gggtggattt cagcaatcat tctattcgga attttagttg tattttcgct 1419601 tttttcaggt ttaatcaatt ctgtggcggg tgcataagct catgaaaaaa gtctggatcg 1419661 gaattggaat cgcagttata gtcgctcttt ttgttggaat caatatatac cggtctgccg 1419721 ctccgacaag cggcagcgcc ggcaaggagg tacagacggg gagcgttgaa gaaaatgaaa 1419781 tctcatcaac ggttatggtt cctggcacgc taaaattttc aaatgaacag tatgtctttt 1419841 atgaagcgga taaagggaca ttagaagaca ttaaagtaaa ggaaggcgat aaagttaaaa 1419901 agggcacggc tttagtcacc tatacaaatg agcagctgag cctggaaaaa gaacagaacc 1419961 agttaacgtc tgaatccaac cggcttcaaa ttgaccaaat tcaagaaaag ttaaaagcct 1420021 tggacagcaa agaaagagaa ctggaaaaac aggtaggaaa gaaagaagca gaaaaacaaa 1420081 tcgaatctga acggacagag cttcaaatgc agaaaaaaac agcggagatc gaattaaaac 1420141 aaaccgagct tcagcggcag tcacttgcca accgggtgtc agatttagaa gtgaaaagcg 1420201 aaattgaagg caccgttatt tctgtcaacc aagaagcggc atccaaaaag tcagatattc 1420261 aagagcctgt catacatatc ggcaacccaa aagaccttgt cgtctcaggg aaattgtctg 1420321 aatacgatac attgaaagtc aaaaaaggcc agaaggtcac actcacttca gatgtaatac 1420381 agggtaaaac atggaaaggc acggtttccg cagtcgggct tgttccggat cagcaggaga 1420441 gcgctgcggc acaaggaaca gaacaggcgg tccaataccc gcttcaagtg aaaataaaag 1420501 gaaatcttcc agaaggaaag ccaggcttta aatttatcat gaatattgaa acagataaac 1420561 ggaaagcaaa tacgcttcct tcaaaggcag tcaaaaaaga agatgaccaa tattatgtgt 1420621 atacagtaaa agacggaaaa gcaaagcgag ttgatgtcaa aatcggcgaa gtgacagatg 1420681 acctgacaga aattaaagag gggcttaccc aagatgatca agtcattttg aatccatctg 1420741 atcaggtgac tgacggaatg gaagtgaaat cctaaatgat tcagctttct aatgtgcgaa 1420801 aaagctacca gatcggaaag gaaacgtttg atgttctcca ttctattgat ttggacattc 1420861 atcaaggtga atatgtctcg attatggggc cgtcaggatc aggaaaatcg acgatcatga 1420921 atattatcgg ctgtcttgat cggccgactt ccggtacata tcaattggac ggcgaagaca 1420981 tttcttcata taaagataaa gaactggcgg cagtccgtaa ccggtccatc ggttttgtat 1421041 ttcagcaatt tcagcttctt ccgcggctga acgcaaaaaa aaatgtcgag ctgccgatga 1421101 tttattccgg gataggcaaa aaggaacgtc aagagcgggc tgagagagca ttggaaaagg 1421161 tcgggttagc cgatcgaatg ctccacatgc ccaacgagct gtcgggcggg cagaagcagc 1421221 gggtggcgat tgcgagggcg atcgtgaatg agccgaaatt gattttagct gatgaaccga 1421281 ccggcgcgct ggatacgaaa acaagcgagg cgattatgga tcagtttaca gcattaaatg 1421341 ccgagggaac gacaatcgtt ctggttactc acgagcctga agtagcagat tgcacgaatc 1421401 ggatcgtcat ggtgcgtgac ggaaacattg ttcctgccag ctccggacaa aggagtgtgg 1421461 gagaatgagc ctgttggaaa acatcagaat ggctctaagc tctgtccttg cccataaaat 1421521 gcgttcgatc ttaacgatgc tcggcattat cattggtgta ggctctgtca ttgttgtcgt 1421581 tgcggtagga cagggcggcg agcaaatgct gaagcagtcg atcagcggcc cgggaaatac 1421641 tgtggagctg tactatatgc ctagcgacga ggagcttgca agcaacccga atgccgcagc 1421701 tgaatctacg tttacagaaa acgatattaa aggtttaaaa ggaatagaag gcattaaaca 1421761 agtcgttgct tcgacttctg aaagtatgaa agcgcgttat cacgaagaag aaaccgatgc 1421821 tacggttaac ggaataaatg atggatacat gaatgtcaat tctttgaaaa tcgaaagcgg 1421881 cagaaccttt accgacaatg actttctcgc ggggaataga gtcggaatca tctctcaaaa 1421941 aatggctaaa gagctgtttg ataaaacctc ccctctaggt gaagttgtct ggattaacgg 1422001 acagcccgtt gaaattatcg gcgtgctgaa aaaagtaaca ggcttgcttt ctttcgattt 1422061 aagtgaaatg tatgtgccat ttaatatgat gaaatcctct tttggcacaa gtgatttcag 1422121 taacgtatca ttgcaggtcg aatcagcaga cgacataaaa tcggctggaa aagaagcggc 1422181 acagctggta aatgacaatc atggcacaga ggattcgtat caagtgatga acatggaaga 1422241 gattgcggcc ggaattggca aagtaactgc aattatgacg acgattatcg gctcaattgc 1422301 aggtatttcc cttttggtcg gcggaatcgg tgtcatgaat attatgctcg tatcagtcac 1422361 agaacggacg cgggaaatcg gaatcagaaa atcacttggt gcgacgaggg gacagattct 1422421 gactcagttt ttaattgaat cagtcgtatt gacgctgatt ggcggtctgg tcgggattgg 1422481 tattggatac ggaggggccg cgcttgtttc agccattgcg ggctggccgt cactcatatc 1422541 ctggcaggtt gtatgcgggg gcgtgctgtt cagtatgctc attggtgtta ttttcggcat 1422601 gcttcctgca aataaagccg caaagcttga tcccattgaa gcgctgcgtt atgagtagcc 1422661 tcatgcaaca tgcatgaggt ttttttatgt ttagtgattt ctactatgaa tataaaagac 1422721 ttttttcatt aaaataagaa gaaaatgtcg tacaattgtc cttatttttg tcgaatttac 1422781 agtttacaaa ccctatagac atacgttaat atggagaaac gtgaaagatt ttgatagtta 1422841 ttgaatgaat ttgaatgatt ttagttgcct aaaccgaaaa tagcgtttac aatgaaattg 1422901 tattcaaaat gaatacgttt tcattaggag gtgaagcatg ctaactcctg aacggcatca 1422961 attgattatt gatcaaatag aaaagcatga tgtggtaaag attcaagagc ttataaatct 1423021 gactaatgct tctgaatcaa caatcagaag agatttatcg acccttgaag aacgcggttt 1423081 tttaaagcgc gttcatggtg gagcggccaa gctttccgat atcagacttg aacccgatat 1423141 gcttgaaaaa tcatccaaaa accttcacga taaactgaag attgctgaaa aagctgcttc 1423201 tcttttagaa gaaggggatt gcatttacct tgatgcaggc acgacgacat tgcacatgat 1423261 tgattttatg gataaaacca aagatattgt cgttgtcaca aacggggtaa tgcatatcga 1423321 tgcattaata aggaaagaaa tttcttttta tctgcttgga ggatacgtaa agcacagaac 1423381 gggcgcgatt attggaggcg cttcattggt tgccatggac cagtacagat ttgacaagag 1423441 ttttctgggg acaaacggtg tccatacaga ggctggattt acaacgccgg accctgatga 1423501 ggccctttta aaacagaaag cgatcaaaca ggcaaaacac gcttacgtct tagcagaccc 1423561 ttcgaagttc ggagaaattt cattttcggc attcgccgga ataggcgacg caacaatcat 1423621 tacgactgac gctgaagagc ttacattcga taattaccaa gaaaaaactg tcgtaaaggt 1423681 agtgaaacca tgatttacac tgtaacactt aatccatctg tcgattatat agttcacgtt 1423741 gaagatttta ctgtaggagg cctgaaccgt tcttcgtatg ataccaagta tccagggggc 1423801 aaaggcatca acgtatcgag actgctgaaa agacaccatg tggcgtctaa agcgctcgga 1423861 ttcgtcggcg gatttaccgg agaatatatc aaaacatttt tacgggaaga aaacctggaa 1423921 acagcttttt ctgaagtaaa aggggatacc cgtatcaatg taaagctgaa aacgggtgat 1423981 gaaactgaaa ttaacgggca gggaccgaca atttcggatg aagatttcaa agccttttta 1424041 gaacagttcc aatctttgca agagggagat atcgttgttc ttgcaggaag cattccatct 1424101 tcactccctc acgatactta tgaaaaaatc gcagaggcct gcaaacagca gaacgcacga 1424161 gttgttctgg atatctcagg cgaggctctt ttgaaagcaa cagaaatgaa accatttttg 1424221 atgaagccaa atcatcatga gcttggagaa atgttcggca cggccattac atctgttgag 1424281 gaagccgttc cttatgggaa aaagcttgta gaacaaggcg ctgaacatgt aatcgtatca 1424341 atggccggag acggagcgct tctgtttacg aacgaagctg tttattttgc taacgtgcca 1424401 aaggggaaat tggtaaactc agtcggagca ggggattccg ttgttgcagg tttccttgcc 1424461 ggaatttcca aacagctgcc gcttgaagaa gcattccgct taggagttac ttcaggcagt 1424521 gctaccgcgt tctctgaaga acttggaaca gaagaatttg tccagcagct tcttcctgaa 1424581 gttaaggtca cacgtctata gaggaggaaa cacaagtgaa aataactgag cttttaacga 1424641 agcatacgat aaagcttaat attgagagca aagaaaaaga aaatgttatt gacgaaatgg 1424701 tcactgttct tgataaggct ggaaagttaa atgaccgaca agcctataaa gaagccattt 1424761 taaatcgcga aagccaaagc tccacgggta tcggtgaagg aatcgctatc ccccatgcga 1424821 aaacggcaag cgttatcaac ccggcgatcg cgttcggacg ttcaaaagac ggcgtcgatt 1424881 atgaatcatt agacggccag ccggctcact tagtgttcat gatcgcggcg actgaaggcg 1424941 caaacaacac tcaccttgaa gcattgtcaa gactttcaac gctgttaatg cgtgaagaaa 1425001 tccgtaagca gctccttgaa gctgagtctg aagatgccat catcgacatt attaatcagc 1425061 acgataaaga tgatgacgaa gaggaagagg aagaagaagc ggcaccagca cctgccggaa 1425121 aagggaaaat tttagcggtt actgcatgcc cgacaggtat tgcccataca ttcatggctg 1425181 cggatgccct taaagaaaaa gcgaaagagc ttggtgtgga aattaaggtc gaaacaaatg 1425241 ggtcaagcgg cattaagcac aagctcactg cccaagaaat cgaagatgca cctgcaatca 1425301 ttgtcgcagc ggacaagcag gttgaaatgg aacgttttaa aggcaagcgc gtacttcaag 1425361 ttcctgtaac ggcgggtatc agacgtccgc aagagcttat cgaaaaagcg atgaatcaag 1425421 atgcgccgat ttatcaaggc agcggcggcg gttcagcagc ttcaaatgat gatgaagaag 1425481 cgaaaggcaa gtctggaagc ggtatcggaa acacgtttta taagcacctg atgagcggtg 1425541 tcagcaacat gcttccgttc gtagtcggcg gcggtattct cgttgcgatt tcattcttct 1425601 ggggaattca ctctgctgat ccgaatgatc ctagctacaa cacgtttgca gcagcattaa 1425661 actttatcgg cggcgacaat gcattaaaac tcattgttgc agttctggcc ggtttcattg 1425721 cgatgagtat tgcagatcgt cctggttttg cgcctggtat ggtcggcgga tttatggcaa 1425781 ctcaagcgaa tgctggattc ttaggcggct taattgccgg attccttgcc ggttatgtcg 1425841 tgattttact gaaaaaagta tttacgttta tccctcagtc acttgatgga ttaaaacctg 1425901 ttttgattta cccgctgttc ggtattttta tcactggcgt attaatgcaa tttgtcgtca 1425961 atacacctgt agcggcattt atgaatttct taacaaactg gcttgaaagc cttggtactg 1426021 gaaaccttgt gttaatgggt attatcttgg gcggcatgat ggcgatcgat atgggcggtc 1426081 cgcttaataa agcagccttt acgttcggta tcgccatgat cgatgcaggc aactatgcgc 1426141 ctcatgcagc aatcatggcc ggcggtatgg ttcctccgct tggtatcgca cttgcaacaa 1426201 ccattttcag aaacaaattc actcagcgtg accgtgaagc tggtattaca tgctatttca 1426261 tgggagctgc tttcgtaaca gagggagcga tcccatttgc tgcggctgat ccgcttcgcg 1426321 tcataccagc tgctgtagtc ggtgcagctg ttgccggcgg attaactgaa ttcttccgag 1426381 taacgcttcc ggcgcctcat ggaggagtat tcgtagcttt cattacaaac catccgatgc 1426441 tttacctttt aagtatcgtg atcggtgctg tcgtgatggc aattatcctc ggtatcgtca 1426501 aaaaacctgt tacagaaaaa taagaaaaaa agcgtccttg gttcgaaagg acgctttttc 1426561 ttatccggcc ggcagggagc gcggttaagt tatgtatttt attctttttt atgataaagt 1426621 aaaagaagag aaacaactga catagcaatt gtctaggagg aaacactttg accgaggaaa 1426681 aaaatacgaa tactgagaaa acggcgaaga aaaaaaccaa tacgtacctg gaatggggta 1426741 aagcgattgt catcgctgtt ctgctggctc tcctgatccg tcactttttg tttgaaccgt 1426801 atttagttga aggttcatct atgtatccca cattacatga cggagaaagg ctgtttgtga 1426861 ataaaacagt caactatatc ggcgagctga agcgcggaga tatcgttatt atcaacggtg 1426921 aaacttctaa aatccattat gtaaaaagat tgatcggaaa gcctggagaa accgttcaaa 1426981 tgaaggatga cacgctttat ataaacggta aaaaagtagc cgagccttac ttgtctaaaa 1427041 acaagaagga agcagaaaaa cttggtgtca gtctgacagg agactttgga ccggttaagg 1427101 ttccgaaagg caaatacttt gtcatgggag ataaccggct gaattctatg gacagccgaa 1427161 acgggctggg actgatcgcg gaagatcgaa ttgtcggcac atcgaagttt gtctttttcc 1427221 cgtttaacga aatgcgtcaa acaaaataaa aacgccttgc tggcctagga cagcaggcgt 1427281 ttttattttg aaaaagaagc gaccaatgca atgcataaaa ccgtgatgaa cactgaaccg 1427341 ataatagcca gcacactgaa gaaaaggtga acctgtttgt tctcttttcc gcgcttttct 1427401 aatagccgtt tagaaaaaat gtgcgaaaat atgtaaataa gggctatgcc tatatataag 1427461 ccgatatctt tggcggtaaa gcctgttacg gcaaggtaaa agcccgtaaa aaagatcagt 1427521 aagcaatatt cagtaagtgt taaaagcctc aacgtgttcc tccatgagag tgtgtaattt 1427581 tccaggcgga tgcattctct ctctttaatt gtaacacagc tggctggttt gggtgtataa 1427641 gtgttttctc tctgttttat cagggaatca tttctcttgc cctgcattca tggtatactt 1427701 ttattgatga tagacatgat ggaggataat aaatgattgc tgtaaataat gtaagcttgc 1427761 ggtttgcgga tcgcaagtta tttgaagatg ttaatattaa atttacccca ggcaactgct 1427821 atgggttaat tggtgcaaac ggtgccggta aatcaacgtt tctaaaggtg ctgtcaggcg 1427881 aaatcgagcc tcagacaggc gacgtgcata tgagtcctgg cgagcgtctt gccgtcttga 1427941 agcagaacca ttttgagtac gaagagtatg aagtgctgaa agtggtcatt atgggccaca 1428001 aacgcctgta tgaagtcatg caggagaaag acgctattta catgaagcct gatttctcag 1428061 atgaggatgg gattcgtgct gctgagctag aaggtgaatt cgcggaactg aacggttggg 1428121 aagcggaaag tgaagctgcg atcctgttaa aaggccttgg tatctcagaa gatctgcaca 1428181 caaaaaagat ggcagacctc ggcggttcgg agaaggtaaa agttctcttg gcacaggcat 1428241 tattcggcaa gccggatgtt ctgctgctcg atgagccgac gaaccacctg gaccttcagg 1428301 caattcagtg gcttgaagag tttctgatta actttgaaaa cacagttatt gtcgtatccc 1428361 atgaccgtca ctttttaaat aaagtatgta cgcacattgc cgaccttgat tttaacaaaa 1428421 ttcaaatcta tgtcggaaac tatgatttct ggtacgagtc aagccagctg gcgttaaagc 1428481 tttctcaaga agcgaacaag aaaaaagaag agcagattaa acagcttcaa gagtttgtcg 1428541 ctagattcag cgccaatgcg tctaaatcta agcaggctac atcaagaaag aaacttctcg 1428601 aaaaaatcac gctggatgat attaaaccgt cttcccgccg ctatccttat gttaacttca 1428661 cgccggaacg ggaaatcgga aatgatgttc ttcgcgtgga aggcttaaca aaaacaatcg 1428721 atggcgtaaa ggtgcttgac aatgtcagct ttattatgaa tcgagaagat aaaattgctt 1428781 tcactggccg aaatgaactt gctgttacta cgctgtttaa aatcatttcc ggggaaatgg 1428841 aagctgacag cggaacgttt aaatggggtg ttaccacatc tcaagcgtat tttccaaaag 1428901 acaacagcga atatttcgaa ggcagtgatc tgaaccttgt agactggctt cgccaatatt 1428961 ctccgcacga ccaaagtgag agctttttac gcggtttctt aggacgcatg ctgttctctg 1429021 gagaagaagt ccacaaaaaa gcaaatgtac tttccggggg agaaaaggtc cgctgtatgc 1429081 tgtcgaaagc gatgctttct ggcgccaata ttttaatttt ggatgagccg accaaccatt 1429141 tagacctaga gtccattaca gcgctcaata acggcttaat cagctttaaa ggcgctatgc 1429201 tgtttacttc ccatgaccat cagtttgtgc agaccattgc caacagaatt atagaaatta 1429261 cacctaacgg catcgtcgat aagcaaatga gctatgacga gttccttgaa aatgctgatg 1429321 tgcagaaaaa attgactgaa ctatacgccg aataaaaaag cagagatttc tctgcttttt 1429381 ttgataccta aatgtgaaag gagatcacaa catgaaattt ttggttgtcg gagcaggtgg 1429441 agtaggcggg tatattggcg gacggctttc ggagaaagga aatgatgtga catttctcgt 1429501 gcgccaaaaa cgagctgagc agcttaaaaa aaccgggctt gtcatccata gtgaaaaagg 1429561 gaatgtatca tttcagcccg aactaatcag tgccggagaa acagggcaat ttgatgtcgt 1429621 tatcattgct tctaaagcat actcgcttgg tcaagtgata gaggatgtca aaccatttat 1429681 ccatcaagaa tctgtcatta tccctttttt aaatgggtac cgccactatg agcagctatt 1429741 tgcggcattt tcaaaagaac aggtgctggg cggcctgtgt tttatagaaa gtgctttaga 1429801 caacaaagga gaaattcatc atacgagcgc atcgcatcgt tttgtatttg gagaatggaa 1429861 cggcgagcgt acggagcgga taagagcgct tgaagaggca ttttcaggtg tgaaggctga 1429921 agtcatcatt agcgggcata tcgagaagga catttggaaa aagtatctct ttattgcagc 1429981 gcaagcgggg atcacaacgt tatttcaacg accgcttggc ccaatcctcg ccacagaagc 1430041 cggacgtcac acggcccaaa ctcttattgg ggaaatttgc actgttttac gaaaagaagg 1430101 tgttccggct gatccggctc ttgaggaaga gagctttcgt acgatgacca gcatgtctta 1430161 ccatatgaag tcctccatgc ttcgggatat ggaaaacggc caaacgacag aaggcgacca 1430221 cctgcatgga tttttgattg aaaaagcaaa acgtttatct ctcgctgcac cagtattaga 1430281 aaccgtttat gcgaatctgc aaatgtatga agcagaaaaa taaaaaaagg aggcggaaaa 1430341 gcctcctttt atttacttaa aaagcccaat ttccgtttct gaagataggc tctcttttcc 1430401 cgtctgccgt aattccgtca atattcatat ccttagaacc gatcataaag tccacgtgtg 1430461 taatgctttc atttaggcct tctttgacaa gctcttcacg agacatctgc tttccgcctt 1430521 caatattaaa ggcataggcg cttccgatcg ccaaatgatt tgacgcgttt tcatcaaaca 1430581 gcgtgttata gaaaagaatg tttgattgtg atataggcga atcgtaagga acaagtgcca 1430641 cttcacctaa atagtgagaa ccttcatctg tttccaccag ttcttttaaa atatcctcac 1430701 ctttttcagc tttaatgtcg actatacggc cattttcaaa cgtcagggtg aaattttcaa 1430761 taatatttcc gccgtagctt aatggttttg tgcttgatac cactccgtca accccgtctt 1430821 tttgcggcag cgtgaacact tcttctgtcg gcatattggc cataaactca tggccacttt 1430881 cattcacgct tcccgcacct gcccaaacat gcttcctagg cagcttaatt gttagatcag 1430941 ttccttctgc ttgataatgt aaggcagcgt aatgtctctc gttcaaatgg tcaacttttt 1431001 catgaagatt ttggtcatga ttgatccacg cctgaaccgg gttgtcttca tttacgcgcg 1431061 tcgctttaaa aatttcttcc cacagaaggt ggatcgcttc ctcctctgat ttgccaggaa 1431121 acaccttgtg agcccagcct gctgatgccg cacctacgac agtccagctg actttgtctg 1431181 attgaatata ttgtctgtat gtatgtaatg ctttgcctgc tgctttttgg aatgccgcaa 1431241 tccgtttgga atctatacct tttagcaagt ctgggttcga cgacacaaca gaaatgaaag 1431301 cagctccatt tttggcaagc tcttctctgc cttttgcttc ccattcagga tattcttcaa 1431361 atgcttcaaa cggcgcaagt tcgtatttta atttggcgac ttcgtcatcc tgccaattca 1431421 cggtgacgtt ttttgcgccc ttttcatatg cgtgttttac aattaaacgg acaaaatccc 1431481 gaacgtctgt tgaagcattt acgactacat actggccttt ttggacatta acgccgactt 1431541 ctaccgccag ctgtgcatat gtatttaatt tctgtgaaaa tgaatccatg aatcattcct 1431601 ccaagctttt ttctcatcat atcaaatatg atcctataaa ggaaagaagg agcccaaagt 1431661 gaaaaaccca aaacgacacg tcttgggttt tttcaatatt atggatgatt cagttttaca 1431721 gtgccgcctg caggcgaatg gggcatattt gccaaagaaa tgctcatgcc tccaagaata 1431781 attccgctta aaatggctgc gatcgctact cttcttccta aatctcttag catctgtttc 1431841 ctccttaacg tttctccatt tcccacaata tgaaggaagt gaggaaaaaa gaagcaagaa 1431901 atttgccgcg tgtgagaatt ttgcgggtaa agactattta attgcctttt gcagcttatc 1431961 aatcacttct aaagaacggc ctgtgccgat tgctacagat tcaagcgggt tttgcgccac 1432021 gtgtacaggc acgacaatct cttctgtgag ccattcttta attccattaa ggagcgcgcc 1432081 gccgcctgtt aaaataacgc cgcgatcaac aatatctccg ctcaattcag gcggacagtc 1432141 ctcaagtgtc gctctgatgg cttcaagaat atgcaggagg gattcacgca ttgcatcttg 1432201 aatttcgttg gattgaagca taatggtttt tggaagacct gtcacgaggt cacgtccccg 1432261 aatttccatt gcctctggta tatgttcaat cagagcatgg ccaatttcca tttttacctg 1432321 ctcagctgtg cgttcgccga tcagcaaatt gtatttttta cggacgaaag aaacgatatc 1432381 ctcatcaagc tggtctccgc cgatcctgat agaatggcag gaaacaacgc caccgaagga 1432441 aataatagcg acctctgtcg tccctccgcc gatatctact accacattgg caaccggctc 1432501 atcaaccggt aaatccgctc cgatggcggc tgcaactggc tcttcgatta aatgaacgtt 1432561 tttcgcgccg caatttttca ccgcatcact gatggcgcgg cgttctactg ctgttgagcc 1432621 tgatggtgtg caaacgacta cgttcggttt tctgaacgac atgccgatgc tttttgcggc 1432681 ttttttcata atgtgcttta gcaggtcagt tgtcatatca tagtctgcga tcacgccatc 1432741 tttcatcggt ctgacagcga caatttttcc cggtgtttta ccgatcatgt ttttcgcgtc 1432801 agctccgatt gcaagcactg cttttgtcgt cgtatccact gcgacaacag atggttcatt 1432861 taggataatc cctttatttt tgctgtaaac aagtatatta gctgttccta agtcaatccc 1432921 gatttcagtt gattgaaaca tgttttcacc caatctctat cctaatttaa tatgattcta 1432981 catttaaagt ttctcagaaa tactgcgatt tttgggggtg tgcgtcggta aagaaatgtt 1433041 tttgtaaaaa atcaaggaac tgtgtaacag aagtaataca tttttcggtt ttatggaaaa 1433101 aatatcttgt aattcttata gaaagcggga aactttttca aagtttcatt cgtctacgat 1433161 atattgaggt acatccttaa aacattacat gagaaaagaa acatttaaag gaagaagggt 1433221 ttttatgaaa tcaataggtg ttgtgagaaa agtagatgaa ttaggccgca ttgtcatgcc 1433281 gattgagttg agacgggcat tggatattgc cataaaagac agcattgagt tttttgttga 1433341 cggagataaa attatcttga aaaagtacaa acctcatggc gtttgtttaa tgactggaga 1433401 aatcacttca gaaaataaag aatacggcaa cggtaaaatt acgctaagcc ctgagggtgc 1433461 acagctgctt ctcgaagaaa ttcaagccgc tttaaaagaa taaaattatg ctaaaaaagg 1433521 cggagtgata tcatctccgc cttttttgcg tgccaatttt tgattaccgc cgcctaagat 1433581 aagacatcaa gatatttggt aatgaatgat ttgggatact ttacatattt tactcaatta 1433641 tttgtcgaag aatggtacaa taagtagaga aacacaagcg gcaggtggtc atatgagaaa 1433701 atatcaagct cgtatcattt ccatcatttt ggcaatgatt tttataatgt tttgggatta 1433761 tttattttat tttataggca aaaacccgat taattggcct gttgatattg tgtatactgc 1433821 agtcacgctg gtaagtgtct ggatgttggc ttattatatt gatgagaaac agcagctggt 1433881 taagaaaatg aaggataacg aatggaagta taaacagctt tctgaagaaa aaaaccgcat 1433941 catggataat ttgcaggaaa tcgtatttca aacgaatgca aaaggtgaaa ttacatattt 1434001 aaaccaagcg tgggcatcta taaccgggtt ttcaatcagt gaatgtatgg gaacaatgta 1434061 taacgattac ttcataaaag aaaagcacgt agccgaccac attaacaccc aaatccaaaa 1434121 caaagcgtct tctggcatgt ttacggcaaa atacgtgaca aaaaacggca cgattttttg 1434181 gggagaagtt cattataaac tttactatga ccgggatgac caatttacag gcagcctggg 1434241 tacaatgtca gatatcactg agcggaaaga ggctgaagat gagctcattg agattaatga 1434301 acggctggcg agggaatccc agaaactatc aatcacaagt gaacttgccg caggtattgc 1434361 tcatgaggtc agaaaccctt taacatctgt cagcggtttc ctccagatta tgaaaacaca 1434421 atatccggac agaaaagact attttgacat catcttttca gagattaaaa gaatcgattt 1434481 agtgctcagc gagctgctgc tgcttgcaaa accgcaggca atcacattta aaacacacca 1434541 gcttaatgag atcttgaaac aagtcacgac attgcttgat accaatgcaa ttctgtccaa 1434601 tatcgtcata gagaaaaatt tcaaagagac agatggctgt atgattaatg gagacgaaaa 1434661 tcagctgaag caggtcttta tcaacatcat taaaaacgga attgaggcaa tgccaaaggg 1434721 cggtgtcgta accatttcaa ctgctaaaac cgcctctcat gcagtgataa gcgtaaagga 1434781 tgaaggaaac ggcatgccgc aggaaaagct gaagcagatt ggcaaacctt tttattcaac 1434841 aaaagaaaag ggcactggac tgggacttcc catttgtttg agaatcctga aggaacatga 1434901 cggggaattg aaaatcgaaa gtgaagctgg aaaaggcagc gtctttcaag tggttttgcc 1434961 tttaaaatca gacagctgag aggagaaaaa taaagtgaac tcgcttctgt ttgtatacgg 1435021 gacattaaga aagcatgaaa aaaaccatca tttgctggca caatcggcat gtatcaatga 1435081 gcaggcgaga acaaagggaa gtttgtttgc tgcaaaagag gggcccacag ttgttttcaa 1435141 tgatgaagat gaaggctata tatatggcga agtatatgaa gcagatgaat tgtgtataca 1435201 taagctcgat caattttttc aaggatatca taaacaaacg gtgtttgtag aaacggatgt 1435261 cgggattaaa attgcgctta tttattttat gaacaaagac gggtgtgccg gttttacgaa 1435321 aataagcagc ggcgactgga aagaacatca gatgatcagc aaatcgaaaa atcccattta 1435381 ttattttgcc tatggatcat gcatggataa tgcccgcttt caaaaagcgg gagtcgatca 1435441 ctattttcaa gatccagtag gaagagctgt tttaaaagga tacacaaccc gcttcacgct 1435501 aaaaagggaa gacggttcaa gagcggacat gttggaagac ggaggaacaa cagaaggcgt 1435561 tttataccgt atcccttatt ctgctctctc ctatctatat aaaagggagg gcgtcgaatc 1435621 tcttacgtat cggccggcat ttgtagacgt tgaagctggc ggaaggcact acaaagactg 1435681 tttaaccttt ctcgtcctcc aaaaagaagc ggaaattgcc ccgcctcagc actatcagat 1435741 tgaaatcgaa cgcggagcgg agctgtattt gtcgcctgag tttactgaaa agctcaagcg 1435801 gcatatgaat tcgctgccaa aaggataaca ctgtaacaaa agaatatgat aaaatttgat 1435861 caatatcatg tcatataaag gagcaccacg atgaaaaaag aatttgcggt aattgggctg 1435921 ggccgttttg gtggcagtat ttgcaaagca ttaagcgaag aaggcgtcga ggttatggca 1435981 atggatatcg atgaagataa agtcaacgag tatgccaaga ttgcatctca cgcagttatc 1436041 ggtgattcga cagacgaatc tgtcctgaaa aatttaggcc tgcgaaattt tgaccacgtt 1436101 attgtagcaa tcggggaaaa tattcaagcg agtattttaa cgacactcat tctgaaagaa 1436161 cttggcgtcc atacgattac agttaaagcg cagaacgatt atcacgaaaa agtgctgtct 1436221 aaaattggtg cggatcacat cgtccacccg gaacgcgata tggcaaaacg aattgcgcat 1436281 aatatcgtgt ccaacaatgt acttgactat ttggagctgt ctgaagagca tagtcttgtt 1436341 gaaatcgtag ctaacagccg cctggctgga aatacgcttc tcgatttaga tattcgcgca 1436401 aaatacggta ttaacatcgt agccataaaa aggggcaagg aagtcatcgt atcaccgctt 1436461 gcaaccgaag tcatccacca agaagatata ctcattgtta ttggatcagt tacagacatc 1436521 tcccgtttcg aaaaaagagt tcttcataca aaatagcagc caaataagcc gtcctcaaag 1436581 ggcggttttt catattatca gaatataaca actttaatga actgagcgtc aatttcttaa 1436641 aatttcattg actaagcaca ggcgttccga tagcatattg taccatataa taaaaaaagg 1436701 aggggcctat ttgaataaag aagcgctagt caataggctg aatgcttcag ccaaaagaca 1436761 aaaagctgat atcgtcatta aaaacggaaa aatcatggac gtatataatc aagaatggat 1436821 atatgaagat attgcgatta cagatggagt tattgtaggc ctcggtgagt atgaaggcga 1436881 aaatatcatt gatgcagagg gacaaatgat tgttccgggt tttattgatg gacatgtaca 1436941 tattgagtcg tcaatggtta caccgattga gttcgctaaa gcagtgttgc ctcatggcgt 1437001 gacgacggtt gttacagatc cgcatgagat cgcgaatgtg tctggtgaaa aagggattga 1437061 gtttatgctt gaacaagctc ggcatacacc gctgaatatc cattttatgc ttccttccag 1437121 tgtgcctgcc gcaagttttg agcgatcagg cgcaattctc aaagctgccg atctcaagcc 1437181 tttttatgaa gaagaagaag tattagggct ggctgaagtt atggattatg tgtcggttca 1437241 gcaggctgaa aaagacatgg ttcagaaact gcttgatgcc cgtgtggcag gaaaaaggat 1437301 agacggtcat ttagctggtt tatcaacaga cctcattaac atttacagaa ccgcatttgt 1437361 cttaaacgac catgaagtaa catcgaagga agaagccctt gatcgtatca gaaggggcat 1437421 gtatgtcatg atgcgtgaag gatcagtcgc caaaaacacg ctcaatgtgc tgccggcggt 1437481 gaatgaaaag aacgcacgcc ggttcttttt ctgtacggat gataagcatg tggatgattt 1437541 attgtcagag ggaagtgtaa accatcaggt gaaaatggcg attcaagccg gacttaatcc 1437601 gtttttagcc tatcagctag gaagcctcaa tgcagccgaa tgctacggat tagatacaaa 1437661 gggagcgatt gccccgggtt ttgacgctga tttgcttttt gtatctgatc tggaaaatgt 1437721 cactgtcaca atgacgatgg taaaagggca gactgttgct gaagacagca aagcggtcta 1437781 tcaggatcat gcttcaactg cagcaccaga tcaggcactg cttgattctg ttaagcttgc 1437841 tgctcctctt aacaaacagg attttcatat gccaatcgat tcagagcagc agatcaatgt 1437901 cattcaaatc ataccaaatc agcttgaaac acgattagta caagttccgg ctcctgttgc 1437961 ccgcgaattt gagcctgaca ctgagcttga tttgttaaag attgcagttg tcgagcggca 1438021 taaaggatta aaagaaaccg gacttggtgt tgtgaaaggt tttggattca agagcggagc 1438081 gattgccaca accatttcac acgactccca taatattatt gccgtcggaa cgaatgatga 1438141 ggatatcgcg gcggcagtta ataagctgca ggaaattggc ggaggattaa caattataaa 1438201 aaatggggaa gagctccatt cagtaccgct gccgattgca gggttattat ccgaccaatc 1438261 tgcagagcaa gtgaatcaaa gcttgctgac gcttcatgat aaattgtcgt taatcggttt 1438321 cacaggcgga tttaatccat ttttgacatt gtcgttttta gcgttgcctg tcattcctga 1438381 tattaaaatg acgactacgg gattattcga tgtaaaatca tttcaacaca tatcactgca 1438441 ataaaaagag gcactccctt agggagtgcc tcttttttta aacctccata atgatcggca 1438501 ggatcattgg acggcgcttt gttttttcgt acaagaaagg tgcaagcgtg tctgtaattt 1438561 cgtttttgat ttcagaccat tgagtcgttt ttcgttccat tactttttgt aagtgatttg 1438621 aaatgagctc ttgagcgtcg ttgatcaagt caccagattc tctcatgtac acaaatcctc 1438681 tggaaatcaa atcaggaccc gctgaaatct tgaagtcgtc catgtcaatg ctgacaacaa 1438741 cgatgacaag tccttcttca gagagaattc tgcgatcacg aagtacgata ttgccaatat 1438801 caccgatacc gcttccgtca atgtacactg aaccggacgg gatttttcct gcaactgaag 1438861 cctcatcgcc tttaagtgct aatacttcac cattatccat gataaagcag ttttcctctg 1438921 ggatgccaca atctgttgca agtttgacat gcatcttttg cattctgtac tcaccgtgaa 1438981 tcggcatgaa gaatttaggc ttgattaaac gaagcatcag cttctgttct tcctgtccgc 1439041 cgtgaccgga tgtatggata tcgttaagag ggccgtgaat aacctcagca cccgcacgat 1439101 acagctggtt gattgttcga ctcacgctga ttgtgttgcc tgggataggg gatgaagaaa 1439161 atacgactgt atccccagga ttgattgaaa tttggcggtg tgtgccgttt gcaattcttg 1439221 ataacgccgc cattggttcc ccttggcttc ctgtacataa aattgttact ttattagcag 1439281 gcatacgatt gatttcgtta tgctcaataa acgtattttt aggacagtta atataaccga 1439341 gtgtctgtcc aatttcgata gccgattcca tactgcgtcc aaatacggca acttttcttc 1439401 cattttgtac agcagcttca attacctgct gcaagcggtg aatattcgac gcaaatgtgg 1439461 cgaagataat tcggccgtcc accttgcgga aaatgtcatg aatgctttct cctacacggc 1439521 gctcagacat ggtaaactcc ggattttcac tgtttgtgct gtctgaaaga aggcacaaaa 1439581 cgccttcttt accgatttcg gccattttcg ttaagtttgc cggctcgccg actggagtaa 1439641 agtcgaattt gaaatcccca gtatgtacga tgtttccggg cggcgttttt acaacaatgc 1439701 cgtaggaatc cggaatactg tgtgttgttc tgaagaatga cacagccgtt ttgcggaact 1439761 ttacaatatc atcctcgccg ataatgttca gtttcgtctg tctcaataat ccatgctctt 1439821 caagtttatt ccgaagtaag ccgatcgcga gttttccgcc gtatacagga atattcactt 1439881 gtctgagcag gtatggaata ccgccgatgt ggtcttcgtg cccgtgggtg ataaaaagcc 1439941 ctttaatttt atcttcgttt ttgactaaat acgtataatc agggatgacg tagtcaattc 1440001 cgagcagttc gtcctcggga aacttgatcc ccgcatcaat cagtacaatt tcatcctgga 1440061 attgcaccgc gtacgtattt ttaccgattt cgcccaaacc tccgagggcg aaaacagcag 1440121 tctgatcatt ttttacaaat ttcataccgc tcataactcc aatactttaa aattttcgct 1440181 ctgttgttca tattctaaga atgcaccatc aacaggtgta ataaactcaa tattaaattt 1440241 cttttctttc agctttgttc tgacgtcacg ctcagatacg ccttcaatat aaagtgaatc 1440301 tgtcttttcc cgaacaggta cttcgtcagc cttctcttga taaaatacct tataaatcat 1440361 tccaaatctc tccttaaatg ccgtatgtta gactcgctca ttctattata ttcgaaaacg 1440421 gaatataagg aaagccttga gcaaaataag gatctctcaa aaagtgaaag atcccttgtc 1440481 aggcaattgc tttcttacgg agcattccgt tccattgtct tctgagtttc tttcttaatt 1440541 tacgcagcat tagccagtcc ctcctttaat gaaaaatttg tcccagagtt cttttataca 1440601 aatagtatac ggagattgag gaagactttt cgtggttatt aatggaattt aatatgattt 1440661 ttgaacgaaa ttgtttgctg aatgacaatc tttttgtatg atgagggtgg gaattgcaga 1440721 ccaagacgat aaaggggaag ttgcgatgga ttctaaatta atcttttttg atattgacgg 1440781 cacaatatat gatcatgata agaatatacc ggaaagtacg agaaaaaccg tggcggagct 1440841 tcagcgccaa gggcatcatg tgtttattgc cagcggccgg tctccatttt tggttaagcc 1440901 gattttggag gagctgggca tccactcatt tatttcctac aatggacagt ttgttgtctt 1440961 tgaaaatcaa gtgatttata aaaatccgct gcctgaaaat gcaatcaggc gattattaaa 1441021 gcaggcggat gaaggcaagc atcctgttgt gtttatggct gaggacacga tgaaagcgac 1441081 tgttgcggat cacccccatg ttctcgaggg aatcggcagc cttaaaacag attatccaga 1441141 gaccgatgac cttttttatg aaggaaaaga aatttttcag cttcttttat tttgtcagga 1441201 tgaagaagaa aaagcttatg ccgcttttcc tgagtttgat ctagttcgct ggcatgagct 1441261 atcgactgat gttctgccgc acggaggttc gaaggcagaa ggaatcaaaa aagtgattga 1441321 gcgtcttccg tttgatatcg gcgatacata tgctttcggc gacggattaa atgatttgca 1441381 aatgattgaa tacgttggga caggcgttgc tatgggaaat gctgttcccg aactgaaaga 1441441 aatcgcggac tttgtaacaa aaccggtgga cgaggatgga attgcatacg ctgtcaaaga 1441501 attgggcctt ttaaaataaa gaaacggctg gcattgtgcc agccgttttc tcttttagcg 1441561 ctcaattgcg attgcatttt caggttcttt gaaaggattt tccttatcaa tatgatcata 1441621 gaacataacg ccgttcaaat gatcgatctc atgctgaaac acaatagccg gaaatccttt 1441681 taaacgaata tcaatatttt cgccttctag tgttgttcct tttactctga tgcgagcata 1441741 gcggggaaca taaccgggaa tcgcttcatc cacagagagg cagccctcgc cgcttgttaa 1441801 gtagcttttt tcaactgaat ggctgacgat cttaggatta aacagagcat agctgtataa 1441861 tttaccggaa gcatcttccg catgaacggc gatcattcgt tttttgatat taatttgagg 1441921 agctgcgagt cctacgccag ggcgcagctt gtatttttcg gctaattctg gattttggct 1441981 gtttttaaca aattcgatca tgtcggccag ctgctgtttt tctgcatcag ttggaggcag 1442041 ctcaacaggt tcggcagtct ctctgagggc tggatggccg tcacgtacga tgttttccat 1442101 agtaatcaag aaacttcact cctaaagctt aatatgtaaa ttatatcgga tttcttcaca 1442161 aaggtgcaac gaaacgaatg accagccgta tatggctggt caatttcatg ctgtgtggtt 1442221 agcaacagcc tccacctaaa taagcagctc cgacaatgat taacagaatg aataaaacaa 1442281 cgattagcgc aaaggtgcgg ccgtagccat atccgcagcc accatatccg taaccaccat 1442341 aactgcagca gcctccgccg taaccatatc catacatatt acataacctc ctcttttaat 1442401 tacgccagag cctttataag taggcatagc gtctaatata acctatgtaa aaacaaaaaa 1442461 gttgtatggt catctgtcct gatttttcac ttttttgatt taatttcagt attgcattta 1442521 tacagcacgg ctattgccaa atgtccccat ggattctata gtagaaattg tcaagattgg 1442581 gggatttaac gtgaaagacg ctataaaacg gcggcctgga atcaagatcg gagctttttg 1442641 tgccatggca ctgatattaa caggatgcat gggacaggac ccggttgatt cacttcatca 1442701 ttcattagaa aaagccgcgg aatcggaaaa gccgtttcaa gaagaacaaa acacactcaa 1442761 agaattagag gccaaagaaa atcagcttta cgatagtgtt atgaagctca atatggatga 1442821 ttataaaaaa attgttgctt tatctaataa ggcgcttgaa aatgtcagca agcgcgaaga 1442881 acacctaaag cttgaaaatg acagcatgaa aaaatcggaa acagaatttg aggaagcaaa 1442941 aacgtcagcg gaacatatta aggaaaaaga cataaaagaa aaggccgatg ccgcagcaaa 1443001 ccatatggag aaaagatata catcatatgg cactatgtat aaagagtata aaaaagcgct 1443061 tgagcttaat aaaaaactgt atatgcagct gaaagacaaa gatttgacaa gagatgatct 1443121 ggatcagcag atcgataaag tcaatgcttc ttatgaaaag atccttaaat atagcggaga 1443181 atttaatgaa caaaccgaaa aatataataa agcccgggaa gatttatatg atgctgcagg 1443241 ctatcgtgtg aaaaagagct gactcgatca gctctttttt tgaatgaaat gcgattcgga 1443301 tttcgttcaa aattttcatt tctattgtag tacagcatag taaggtatac tagtacagtt 1443361 ttgggtgcgg ttggcatctg tttttttgat gaaaatgtaa agcgaataca tttattgaaa 1443421 atcagcgatg aaaacgattg acggttcttc tttatttggt gtaaactaat ccatgttaag 1443481 cggtgttgta ttagtttttt acaacttcga aataatacag ttcaaagcag agtgtaacta 1443541 tcctacataa aaggttttgg caaactgggg atcggctaaa atataatacg acttactgct 1443601 gatactttag ggtaccctaa gtttgtatgt ataaaaggaa tgcacgtcta atgactgttt 1443661 aaaagaaagg aagaggtgac ttagtatggc tgcaaaaacg aaaaaagcta tcgttgacag 1443721 taagaagcaa tttgatgcca ttaaaaagca gttcgaaacg ttccaaattt taaatgaaaa 1443781 gggagaagtc gtgaatgaag cggcgatgcc tgatttaact gatgatcaat taaaagagct 1443841 aatgcgccgc atggtattta cgcgtgtgct tgaccaacgc tctatctcat taaaccgtca 1443901 aggacgtctc ggattttacg ctcctactgc gggtcaagaa gcttctcaga ttgcaacgca 1443961 tttcgcgctt gaaaaagaag actttgttct tcctggatac cgtgatgtgc ctcagttaat 1444021 ttggcacggc cttccattat atcaagcgtt tcttttctct cgcggacatt tcagaggaaa 1444081 ccaaatgcct gatgatgtga atgccctttc tccacaaatc attatcggtg ctcaatacat 1444141 tcaaactgcc ggtgttgcgc taggtcttaa aaaacgcggt aagaaagctg tcgcaatcac 1444201 ttacactggt gacggcggag cttctcaagg ggacttctac gaaggaatta actttgccgg 1444261 agcttataaa gcacctgcaa tcttcgtggt gcaaaacaac cgttacgcga tttcaactcc 1444321 tgttgaaaaa caatctgcag ctgaaacaat tgcacaaaaa gctgtagctg ccggtattgt 1444381 cggcgtacaa gtagacggaa tggatccgct tgctgtatac gcagcaactg ctgaagcacg 1444441 cgagcgcgca atcaacggcg aaggtccaac actaattgaa acacttacat tccgttatgg 1444501 cccgcacaca atggctggtg acgatcctac taaatatcgt acaaaagaaa tcgaaaatga 1444561 gtgggaacaa aaagatccgc ttgtacgttt ccgtgcgttc cttgaaaaca aaggcttatg 1444621 gtctgaagaa gaagaagcaa aagtgattga ggatgcgaaa gaagaaatta agcaagcgat 1444681 caaaaaagct gatgctgaac cgaagcaaaa agtaactgat ttaatgaaaa tcatgtacga 1444741 aaaaatgcct cacaaccttg aggagcaatt tgaaatttat acacagaagg agtcgaagta 1444801 agccatggcg caaatgacaa tgattcaagc aatcacggat gcgttacgca cagaactgaa 1444861 aaatgacgaa aatgtcttag ttttcggaga agacgttggt gtaaacggcg gcgtattccg 1444921 tgcgacagaa ggattgcaaa aagaattcgg tgaagaccgt gtgtttgaca cgccacttgc 1444981 tgaatctggt atcggcggtc ttgcccttgg tttaggctta aacggcttcc gtccggtaat 1445041 ggaaatccaa ttcttcggat ttgtttatga agtaatggat tcagtttctg gccaaatggc 1445101 tcgtatgcgc taccgttctg gcggacgctg gacttcacct gtaacaattc gttctccatt 1445161 cggcggcggt gttcatactc ctgaacttca cgctgacagc ttggaaggtc ttgttgcaca 1445221 acagcctggt atcaaagttg ttattccatc aactccttac gatgccaaag gacttttaat 1445281 ttctgcgatc agagacaatg atcctgttgt cttcttagag catatgaagc tttaccgttc 1445341 tttccgtcag gaagttcctg aagaagaata cacaattgag cttggaaaag ctgacgtgaa 1445401 acgtgaaggt actgatcttt caatcatcac ttacggcgca atggttcatg aatcattaaa 1445461 agctgctgat gagcttgaaa aagacggcat ttctgctgaa gttgtcgacc ttcgtacagt 1445521 aagcccactt gatatcgata caattatcgc ctctgtagaa aaaacaggac gcgcgattgt 1445581 cgttcaagag gcacaaaaac aagccggtat tgctgcaaac gtagtagcag aaattaatga 1445641 ccgtgcgatc ctgagcttgg aagcacctgt acttcgcgtt gcagcgccag atacagtatt 1445701 tcctttctct caagcggaga gcgtatggct tccaaaccat aaagacgttc ttgaaacagc 1445761 aagaaaagtg cttgaatttt aatcaaactg cataatcgag agggaagatg aacgttttcc 1445821 ctctattata tatctgtttt caatgcttac gatgtaaact ttaaaattgc ttaatcaaac 1445881 taggaggtcg agaactgtgg catttgaatt taaacttcca gatatcgggg aaggtatcca 1445941 cgaaggcgaa atcgtaaaat ggtttgtcaa gcctaacgac gaggtagacg aagatgatgt 1446001 actggctgaa gtccaaaatg ataaagcagt agtagaaatt ccttcacctg ttaaaggaaa 1446061 agtattagaa ttaaaagttg aagagggaac ggttgcaact gttggacaaa cgattattac 1446121 gtttgatgca cctggttacg aagatcttca atttaaaggc agcgacgagt ctgacgatgc 1446181 gaaaactgaa gcacaagttc agtcaactgc agaagctgga caagacgttg cgaaagaaga 1446241 gcaagctcaa gagcctgcaa aagctactgg cgcaggacag caggatcaag ctgaagttga 1446301 cccgaacaaa cgcgtgatcg ctatgccttc cgtacgtaaa tatgcacgtg aaaaaggtgt 1446361 agacatccgt aaggttactg gttcaggcaa caacggacgt gttgtaaaag aagatatcga 1446421 cagctttgta aacggaggag cgcaagaagc tgcaccgcaa gaaacagctg caccacaaga 1446481 aacagctgct aaaccggctg ctgcaccagc tccagagggc gaattcccag aaacacgcga 1446541 aaaaatgagc ggtatccgta aagcaattgc aaaagcgatg gttaactcta aacacactgc 1446601 tcctcacgta acgttaatgg acgaagtgga cgtaacaaac cttgttgcac atcgtaaaca 1446661 gttcaaacag gttgctgctg atcaaggaat caagctgact tacttgcctt acgttgtaaa 1446721 agctcttaca tctgcactga aaaaattccc tgttttaaac acgtcaattg acgataaaac 1446781 agatgaagtc atccaaaaac attacttcaa catcggtatc gctgctgaca ctgaaaaagg 1446841 cttgcttgta ccggttgtga aaaatgcaga tcgtaaatct gtctttgaaa tttctgatga 1446901 aatcaatggc cttgcaacaa aagctcgtga aggcaagctt gctccagctg aaatgaaagg 1446961 cgcatcttgc acaattacaa acatcggttc tgccggcgga caatggttca ctccggttat 1447021 caaccatcca gaagttgcga ttcttggtat cggacgcatt gcagaaaaag cgattgttcg 1447081 tgatggcgaa atcgtagcag ctccagtctt agctctttct ctcagcttcg accaccgtat 1447141 gatcgacgga gcaactgcgc aaaatgcatt aaatcacatc aagcgtttac tgaacgatcc 1447201 acaattaatt ttaatggagg cgtaatgtta tggtagtagg agatttccct attgaaacag 1447261 atactcttgt aattggtgcg ggacctggcg gctatgtagc tgccatccgc gctgcacagc 1447321 ttggacaaaa agtaacagtc gttgaaaaag caactcttgg aggcgtttgt ctgaacgttg 1447381 gatgtatccc ttcaaaagcg ctgatcaatg caggtcaccg ttatgagaat gcaaaacatt 1447441 ctgatgacat gggaatcact gctgagaatg taacagttga tttcacaaaa gttcaagaat 1447501 ggaaagcttc tgttgtcaac aagcttactg gcggtgtagc aggtcttctt aaaggcaaca 1447561 aagtagatgt tgtaaaaggt gaagcttact ttgtagacag caattcagtt cgtgttatgg 1447621 atgagaactc tgctcaaaca tacacgttta aaaacgcaat cattgctact ggttctcgtc 1447681 ctatcgaatt gccaaacttc aaatatagtg agcgtgtcct gaattcaact ggcgctttgg 1447741 ctcttaaaga aattcctaaa aagctcgttg ttatcggcgg cggatacatc ggaactgaac 1447801 ttggaactgc gtatgctaac ttcggtactg aacttgttat tcttgaaggc ggagatgaaa 1447861 ttcttcctgg cttcgaaaaa caaatgagtt ctctcgttac acgcagactg aagaaaaaag 1447921 gcaacgttga aatccataca aacgcgatgg ctaaaggcgt tgaagaaaga ccagacggcg 1447981 taacagttac tttcgaagta aaaggcgaag aaaaaactgt tgatgctgat tacgtattga 1448041 ttacagtagg acgccgtcca aacactgatg agcttggtct tgagcaagtc ggtatcgaaa 1448101 tgacggaccg cggtatcgtg aaaactgaca aacagtgccg cacaaacgta cctaacattt 1448161 atgcaatcgg tgatatcatc gaaggaccgc cgcttgctca taaagcatct tacgaaggta 1448221 aaatcgctgc agaagctatc gctggagagc ctgcagaaat cgattacctt ggtattcctg 1448281 cggttgtttt ctctgagcct gaacttgcat cagttggtta cactgaagca caggcgaaag 1448341 aagaaggtct tgacattgtt gctgctaaat tcccatttgc agcaaacggc cgcgcgcttt 1448401 ctcttaacga aacagacggc ttcatgaagc tgatcactcg taaagaggac ggtcttgtga 1448461 tcggtgcgca aatcgccgga gcaagtgctt ctgatatgat ttctgaatta agcttagcga 1448521 ttgaaggcgg catgactgct gaagatatcg caatgacaat tcacgctcac ccaacattgg 1448581 gcgaaatcac aatggaagct gctgaagtgg caatcggaag tccgattcac atcgtaaaat 1448641 aattttcata tcaaaaacag ccccgctttg agcgagggct gtttttttat tttgacagca 1448701 catgctgtaa tggtttaatg atgtcttctt tctttttcac acatccctcg attttcacca 1448761 cgacatggcg ctgatcaaca accataaggg tagggacagt ttcaatctca tcttcccagc 1448821 cttctttttt atcatagacc ttcattttat ctatttgctc gggataatct ttttctaaat 1448881 caagcagtgc atcgtaataa ggcgcttcct ggtctatttg gttctcatca gaaaaaaaca 1448941 ggatttgtgt atgatgaatg ttgtcaatcc ggcttttttt catcggattg atggtggaaa 1449001 gcgtacagcc cgataaagca aatactatta tcagcatggg gaataccgcg cgatatcgca 1449061 tctatcttct cctctgtata aacagtagtt aactagcttt agtttatcac gagagacggc 1449121 ttaatctgct tcttgttacc taattgttat ataattgaaa ccgtttttaa agtgagatta 1449181 catattatat caatcgttta aaatagcaac ctggggtata ttgaattttt tgctgcattc 1449241 ttggatgaaa gttcaagaaa acgtgcaatt acattatgtg ctgtggcata tatatcgagt 1449301 aaagcttctg tatgaagaag atattgtatg atggaaaatg gaaaaacaag gtgaatatga 1449361 tgatatgaaa taaaatgtgt tatacagttt gttgttgaca ttttaaatgt gacatattaa 1449421 tataataaca acaaaagaaa ttaagcgttt tcaaatttca aagaaatggg gaataagaga 1449481 tgggtacgat tgtttgccaa gattgcaacg aagccattca ttactttgaa gatgagaaag 1449541 tgacaacatt atatggaact tgctgcggac aatgtcaatg tcctgttgat gaagagtaaa 1449601 aaaaagcatg cggcttaaag ccgcatgctt tttatttttt attgaattgc tttttgttct 1449661 ttgatgaccc ggatcatatg taaagtcgag tcctcaggtc cttgaacagg gaggcctgcg 1449721 tcaaggtttt taaaaatgta gctgatgttt tcttctgtaa taatttctcc tgggatgaag 1449781 attggaatac caggcggata taccatgaca aattcagcaa taatccgtcc ggatgcttct 1449841 tttaatggga tgacttccgt atttgcatag aaagcatcac gcggagtcat tgccaataaa 1449901 ggtatttctg gaagcagaac ctcagtttgc tgatgtgtta catcttgttc tgacatttgc 1449961 tgtgcgatct cagttaaagc ctctacaagc cggtctgcat cattttggct gtcaccagga 1450021 gtgaaaatac acaaaatatt gtacagatca gaaagctcca cctcaatatt aaaggattca 1450081 cgaagccatt tttccacgtc atgtcctgtc aggccaagac ttttcacaga gataatcaat 1450141 tttgtcggat catagctgta agctgctttc gacccaagaa tctcagaacc gacacaataa 1450201 atgccttcaa tctgattgag gcgatctctc gtctgattgg caagcttgag tgtttcctca 1450261 gcaagctggc ggccttctgt tgcaaggcgt tttctggcaa catccaaaga agcgagaagc 1450321 aagtaagaag ttgacgtagt tgtcagcatg ctcaggatgg attgcactct gtctttagat 1450381 acaaggcctt ctctcatgtt taaaatagag ctttgtgtca gtgatccgcc cagcttgtgt 1450441 acacttgtcg ctgctatgtc cgctcctgcc tgcatagccg atagcggcaa ttcgtcgtga 1450501 aaatgaatgt gaacgccgtg tgcttcatcc acaagcactg gcacatcaaa cgaatgagcg 1450561 agttctacga tgctttttaa gtcggctgca acaccgaaat atgtcgggtt gatgacgaga 1450621 agcccttttg catccggatg ctcggtaagc gcccgtttag cagattcaag tgtaattccg 1450681 tgggagatgc ccaattcatt gtcaatttca ggatgaataa aaattggaac cgctccggaa 1450741 aatacaatag ctgtcataat tgatttatga acatttcttg gaataataat tttatcacca 1450801 ggtccgcaaa cagccattac cattgtcata atggcgccgc ttgttccttg aacagaaaaa 1450861 aatgtatgat ccgctccaaa tgcttcagca gccagatctt gtgcttgttt aataatgcct 1450921 tttggcgcgt gcagatcgtc taatggttca atattaatca aatctatgct taacgcgttt 1450981 tcaccgataa attgtctgaa ttctgggtcc attcctgccc cttttttatg gccgggaatg 1451041 tggaattgaa caggctgtct gcttgcatgc tttttcagtc ctgtgtataa gggtgtttca 1451101 tgttgcgaca attgttttcc cacctttgta atcataccta tgcataatag tgtgtattaa 1451161 aatcagtttc tcaaccgttt tttagacgta aaacaaatga attatattat gaacttgaaa 1451221 gaatgtaaag aacaatttat gatcaaatga agatgctttc tcttaaggga agtaaatcta 1451281 caaggagtga agaaaatgga gtatcaatat ccgatgaatg aagattggac aaccgaagaa 1451341 gcagtggatg tgattgcatt tttccagcag gttgagcttg catatgaaaa aggggcggat 1451401 cgtgaagaac tgcttaaagc ttaccgccgt ttcaaggaaa ttgtaccggg gaaggccgaa 1451461 gaaaaaaagc tatgcggcga gtttgaggaa caaagtacat attctcctta tcgcacggtc 1451521 aaacaggcga gagaatctga tcacgcgaag attaagatgt aagaaaaaga gccgggggat 1451581 atcccggctc ttttttatgc ttgtgttact ttttgggtga gacggtacag aaaagcaagc 1451641 tgtttaaagg catcgtcgat acgctgaagg aattcctggt tattcatatt cagcacttct 1451701 tctttttgga gctggatgcc gcataacagc tcggctttct ttacagtctg caaacgctca 1451761 aacagtgtct tcagctgttc cttgtccatt tcagactgtt tatgtactcc cggttttgtg 1451821 tgatctgcag accaaacgaa gctgtcaggg atatttttcg taatggtttc ttggttcact 1451881 tcaagcaatt tgccgtattc ttctttgata ggggattcat aaataatcgc gaaccataca 1451941 aagacgtggc tttcccataa accaatttgg aaatgcggca gttttttata gcctcttttg 1452001 ctgtttgcga acgccaccca gctgtcagcc gggggattga cggatcttct tgcgtgcttt 1452061 gccacatgcg gaaacatttc atctccggtt aaagctgata aagttggggc aaaatgttcg 1452121 cctagagctg taagcttcgg acggaccgtc tcttttaata cttccatgcg cgcgtctaag 1452181 ccttctattg taaatgtgtt aaagtcttct tcagtgaaac gcatttgtgt catgattttc 1452241 ctccttcatg ctaagtatac atattttatc acagttcata cgagcttcaa aaagattgag 1452301 cgcgtttgaa gtaaggagaa atgtggtaat aaacgagtag gtaaacacac aattttcaga 1452361 atcatgttgc gcgtaaatag aacaatcata cgatataaga agtaatcatt gttgaatggc 1452421 aaaatgggat gcttttttac aaacaaatga tctctggaag gggcgaaaga caatgaggca 1452481 agttgtaaaa gagggattta aggaagagaa aaacaatcgt gttgctgtct ggagactaga 1452541 ggttgattat gaattggcaa ccctatatga agcaatgcag aaagaaaatg aagagcagat 1452601 tgaacaaagc aaaaacaaac ttgagcgact tagaaaagaa tggattcgtc ttaacgggta 1452661 aaaaagcgat agtgaaaacg aaccgcatga atggttcgtt tttacgtgag aagggatatt 1452721 tttcattttc cttgcttttt cattgccgtt atcagtatcc tataaaataa aaggtctaca 1452781 tagaagagag gtacgaacga atgacaaatt ggacggaaat cgatgagatt gcaaagaaat 1452841 ggataagaga agcaggcgcg agaattacac aatccatgca tgaaagcctg acaattgaaa 1452901 cgaaatcaaa tccgaatgat ttagtcacca atattgacaa agaaaccgaa aagtttttca 1452961 ttgatcgaat tcaagaaaca tttccgggac atcggatact cggtgaagag gggcaaggag 1453021 acaaaatcca ctcacttgag ggagtcgtat ggattattga tccgattgat gggacgatga 1453081 attttgtgca ccagcaaaga aattttgcga tttccattgg gatttttgaa aacggtgaag 1453141 gtaaaatcgg tttaatttat gatgtggtgc acgatgagtt gtatcacgca tttagcggca 1453201 gaggagctta tatgaatgaa acgaagctgg ctccattaaa agaaaccgtc attgaagaag 1453261 cgattcttgc cattaatgca acatgggtaa cggaaaacag aagaattgat caaagtgtgt 1453321 tagcgccact tgtgaaaaga gtcagaggca cacgctccta cggttctgcc gctttagagc 1453381 tggcaaatgt cgcggcagga agaatagatg cttacatcac gatgcggctt gcgccatggg 1453441 actacgcagc cggctgtgtg ctgttaaatg aagtaggagg cacctatacg accattgaag 1453501 gagagccgtt taccttttta gaaaaccaca gtgtgctagc cggaaaccca tctatacata 1453561 aaacgatatt tgaagagtat cttcatgctc ggaagtaggc catttgagca ggatgatctc 1453621 agcttgttag aaaagctcgc ggaggctcat cctgtatgga aagaggagga gtttggagat 1453681 aaagatgcag aagactatat catttcctac tccatgtaca acggttcatg gcttgtatgg 1453741 gaaaaagacg gtatgcctgt tgccgtcagc taccatctcg agtggtctcc ttcaaacggt 1453801 aagccgtggc tcggaacggt cctgattgac ccggctgaag aaaaaaaggg acatgcgaag 1453861 atgatcattg aacagatcag caaattgctt agagcgaaac ataaagcgat gtttgcggga 1453921 gttcccattg agcgcaggga atggatactg tttttaagcc aatgcggctt tgaacagctg 1453981 aaaacggaaa aagatgagaa aggcaaatca tttatgatct tggtgaagcc tttagcagaa 1454041 gctgccgtat gataatggca gcttatttgc tgcatgcggg ttcaataaaa agcctctcaa 1454101 acattgagag gcttctgatg atttgaaaat tattttttta ccgcatgaat ataatgaatc 1454161 gtttcaaacg ctgacaaatt gtcttttcga ttactaaaga aaaggtcatt gatgtcgtct 1454221 ggtgatagat gttcatagat cagtaaacca gatgactcta acagatgttc aatctcttga 1454281 taagtgaaac atgatttcat cggttccccg cttgcggcag ccatcttcac catatgttca 1454341 actcgattcg acgtcccttt tgctgtaaaa agtgtttcgt ccgcataatc aaaaacaata 1454401 gagcttccag gcgggacatg agaaaataaa ttgctgatca agcttgcatt ttcttcccgt 1454461 gttacataat aagacactcc gagaaggctg aagaatgttt ttgtgttttt aaatccttca 1454521 tctaagagag gatcatacga aaacgttttg gtgaaatcca taggaacaaa atgaagatga 1454581 cccggaattg tcagatttgc atccttcagc ttattttttt tcaattgctg tgtggccgga 1454641 tgatcaacct cgaaaacctg taagctgttt tctaattctg gatgccgaaa gcagaaagta 1454701 tccagtcccg ctccaagaat gacatactgt tttgccccca ggattaattc gttgtgcaag 1454761 actttttcac aataagaagc acgtgctagg ggcgttggag acagctggat ttgtgcaacc 1454821 cattttaata ttttttcagg atcattttga agacgttcgg cgatctcttt gttgaaaaac 1454881 gatatttctt gaatcatatt tttactgatg tcgataaact ctttttcgtt aatgagatct 1454941 tttgcgataa aatcatcaaa aataagaggt gtgtcatatc ggctgtgata tgcacgggca 1455001 aaagctgaaa ttagagacgt taagctggac tcatttttcc tcatgaaatg atcctccaca 1455061 aaaaataaga ttcccctggc caggagaatc ttattataca tacaaatata ttaatagtaa 1455121 attttagcat aaataaattt ttttgtcaat gtttttgctc ttaactggac gcgcgatcct 1455181 tcacatagcc acgtgacctg tagcagaatt cgtctatcaa ttatgtggac tgaatcatta 1455241 gcttttataa aatgcgcact tgcggctgca tccctcttta tgcaaatcag gagcggtttt 1455301 ctgtctcatg gcagcatctt ttcgtcgttt cagctgagag agaaatcaag atatgtaaca 1455361 ataaaagcct gagggatctc aggcttttcc taatattaca atccaacagc attccaggct 1455421 gcttcaactt tagcggcatc agttgagccg tagaggtcac gggcagactg aatgagagct 1455481 gccttggcat ctttgaacgt ggaagaaggc gtgaggtacg ttgttaacgc acggtaatag 1455541 atttgctgtg atttagatac accaagtttt gtgatggtgt tgtaagcggc tttgtttgga 1455601 attccgctgt ttgtgtgtac accgccataa tcgccttcat ctgtgtttgg aaggtttcgg 1455661 taattggcgt aattgtcagg ctggttgtat tttgtagggt tggacaggct gcgaagagca 1455721 ggctggctga ccgtaatgtc ttcaccgatg tcccagtctt ctgtatcgtt aaaatacccg 1455781 aatacgtcag agaaagactc gtttaatgca cctggctgat tttcataaat caagttggct 1455841 gtttcttggg tgacgccatg tgtcatttca tgcgctgtca catctaatga gccggaaagc 1455901 ggagagaaga atgaaccgtc gccatcaccg taaatcatct ggtctcctgt ccatgcagcg 1455961 ttattgtatt gagtgccgta gtgaacggaa gaaacgattt tactgccttt gttatcatag 1456021 ctgtttcgtt taaagtttga ataaaaataa tcgtacactt taccgaggtt atagtgtgcg 1456081 tcaacggctg cccgctgtga tgaagatgta aatgttttcg ttgtgcttga gacaagcgtg 1456141 cccggaaggc ggctttgtct gttttgcaaa tcatatgtga tgatttgggt gcctgttggt 1456201 tttgaaagat ctcttagaac atattttccg ccttcataag agatgttcaa aggaacagtt 1456261 gcgcccttta gcgttgttcc gcttccagtg gcggcggcat gttctacttt attttgctgt 1456321 tttaaaatgc tgcctgtttc ggcgtcaact aagacttccc agtttgcagg ttcaggctcg 1456381 acatagcgaa tcgtcacgtc gtaagcaaga cgatagctgc cgtcttttgt ttctatcgct 1456441 tttaattcgg ctttattgct gtttttggcc gctccgttag aaacagcgtc tggtgatttg 1456501 ccgatagctt tgaaagcgag tgccagcgct ttttcagaag agactttttg gctgttatct 1456561 gtttttgcag cagattgatt gtgtaattca ccattgaccg catagacatt atcggattta 1456621 tcgacgtgaa cgatcacttg cgaatcttta attggcactc cgttaacgac aggcgcatat 1456681 cgaaagtgct tgtatccaag ggcatcagtc gtgctttcaa caagcttcag ccttttggaa 1456741 gggtcacctt taaaaatgtt gctgttcttt ttcaaaaact gcttgacagc cttgtcattt 1456801 ggtgcagaga gttctgattg cgcaatcgcg tttttggaga ggaaatttgt ttgattctct 1456861 ttaagctgat gaccttcagc agcctgaaca cctggcaggc tgattgataa actcataaac 1456921 gaagcagcga cagcaacaga caatttctta cctaaaccca caataaatcc ccctttttga 1456981 aaatactgaa aactttatat tgttatatta aactagcatt ctggaatact caacaaaaac 1457041 taacataact agacaaaatt gatagtattg tcctgtgttt gtttttgttg aataatatca 1457101 agatgagtca agtgtcatgt ggtggttcat tcaagagtta tgttttttac atatcaaggg 1457161 gaagatgaga tatttttgtt tcatcttgaa actttttgaa aagtccgctg tctaaccgaa 1457221 tgaggcctta ataagaagta aaggattgtt gttcgtgttg gagttattca gtcattatgt 1457281 attgcatttc gaacgttatt ttatattaag cagacaaagc accctgctga ttcaatggtc 1457341 aattgttgtt ctggcgggct tatatctttt ggtgcatcat cccaaaataa accggcagcg 1457401 cacaatgttc ttggcgggtg ttatattgcg gattgtgctg ctggcgggag tgtctgttga 1457461 acttattcac caggtgcaat caacaaactt caccagcgct tacttaagag aggacggaaa 1457521 agaactgctg ccgctgctgc attttttgtt atacggatat gtgctgctga cggcttttca 1457581 ctatatgctg atgccgcgtg atcatggcgg aaagggtaag ttttatacgt tcgaccttgc 1457641 tgttgtcagt ttgccgatcg tacaaatgat ttttagtttc ttttcgtatt ggaaggaata 1457701 cccggatggg atggagccga ttgcattcgt gtttctgttt ttcatcatca ctcttcccat 1457761 tgcgttgaat gtagtgtttt tcaagctgta ttggagaacg gataagatct tactaggctt 1457821 attttatacg ctgattatcg gactgcttgt cttgctgctt gcgccatatc ccaatcaaat 1457881 ctcaaaagat tatggtgcag taatgccata tacgatttat ttggcaatgg cgggattttt 1457941 gatgagctat catctgttcc aaaagtcagg aaaggtttat gtgcgtgtga ataagtgggt 1458001 gacgatggct gtcatggtgt tttttgtcct gctgttaaat ccgatatata acataggaac 1458061 ggctgctttc gctgtatcaa agccagcaaa tgtccatgat tcattcaatt ttgtcgggga 1458121 gcacatttca tcagaaaaag cggaacagat actaaagtca ttttttccta cggatgaaac 1458181 actttatttg cacgatacaa acatggatgt gcattatttc tactcatttg aaagcaaagg 1458241 ttacaaagct gaggtagatg aagtatcgca gctaattcgt aattatgaat acttacaaaa 1458301 agcacatggg aaaaagctaa cgaatcagga gtacaagcga aagtccatcg ctttccttga 1458361 gcgacacgga cgtgtgttac ataaggatca tatcgaaaca aaggtatctc aagaagacgg 1458421 ccagacagtc gtacgtattt acctgaaaaa tcaacttcat aaaaaagatc atgctgatga 1458481 tggcgcggta ttttattggg aaaaggaaac cttaatgggg tttagtgaag atccttcgat 1458541 ttatcagctt gactctcttc tgcatgttca tataacggaa caagacattc acgacaaagt 1458601 ggaacaaatg tttacagcgc tgaacatatc aaaacagcct tatcagatca ctgatattga 1458661 aagcgacagc ctgcttggaa gcatggtgag agttgaaaca aaagttggaa ttgttttgga 1458721 atttgagggc gaatcaggtt gtttacatag tctttcgctt ccgatgaaaa agaatatctc 1458781 aatggctaac agccggctgc agcatcagat attatcgatc ttcgatgctc gtggatcaga 1458841 aaagaagaaa aaaagcagtc agggtgacat ggtgatgtat actgattctt ctaaaacata 1458901 tgagtttgtt gaagctcaag gtcagctaaa cgtttatgta tacagcgata cacctgatca 1458961 gtcattcccc tatacgtatc gtaatggaac attggcttac gaaaaagtag cttctctata 1459021 tcaggatgtc atttacaaaa agcgtatgcg tccgattatc gttcaaagag gggatgaacg 1459081 gcattatgca tggctgatca ttattcagcc gtttggttca aatcgccatg atgcctatgt 1459141 agtggatgga gaaacacaag aggtgaaaag tctttatgaa tcataaagaa aaagagtctg 1459201 tttttgtaga cttatacgac ctgtataaag aaggagagct agaggatgaa tcaatggaat 1459261 ggatgaaaca gcatgaatcc ctatttcaaa agaatgcgga agacttaaag agtaaaactt 1459321 gtttaaagag aagtcccggt gctgaagaag aaagccaaat cagatatatg aaagtatacc 1459381 tgtcttccat gtatatctgt ttcattttat tggccatttg gatgacggtg tggttttatt 1459441 tttaatgaag catagggatt ccattgagga cttgtatcgg cagtattatc aagaaatttt 1459501 aaattattta ttcagaagga ctcatcatct tgaaacagcc aaggacttag cgcaggacac 1459561 gtttgtaaaa gctcttaacg gtctggcttc gtttaggggg cattcttcca tcagaacatg 1459621 gctctacacc attgcgcatc atacctttat caattggtac cgaagggatg tcaaatacca 1459681 atttactgaa atcagcaaaa atgaagggtt aacgcaaaca acttatgacc agcctgaaca 1459741 gtatctgtca cggacggtga aaagcgaaac actgcggcag gagctcctga agttaaaaga 1459801 tcagcatcaa tccgttttga ttttaagaga attccaagag ctttcttatg aagaaatcgc 1459861 tgagatatta ggatggagtc tttctaaggt gaataccaca ttgcaccggg ctagattaga 1459921 gctaaagaaa aacatgacga aaagtagaga ggaggagcgg atatgacctg ctttctagta 1459981 agagacctgc ttcctctgta tcttgaaggt gattgtaaaa gagaaacgga acacgttata 1460041 gaagagcatt taaaaatgtg cagcagctgc agagacatgt atgacacgat ggctgagcca 1460101 tttgaattgg aaagcgaaca ggccgttgag gaggcttatc tgccggaaga agaactgcgt 1460161 tttaaacaga ggtactatgg attactgatc atgaaagctg cctgctggtt tggagcggcg 1460221 gttgccatga tgctgatcat caaactgctg atataaaaaa agcgcttgtc cgattccggc 1460281 aagcgctttt ttacattaag cctggggatg aatcatatcg taaatagcgg caagctgttc 1460341 ttgtgacagg gcactgaaga gtttttcata aacgtcagct tgcagtggcg ttgcacctgc 1460401 ttgtagcgct gcgtctttat catagctgta cacatcatct tgtagcacaa tggctgcttg 1460461 aagaatgtga atcttgagag aaacagcgga gaaaaattgt tcaagtgcaa gtgcttcttt 1460521 ttctgtgaag ccaagttcaa ctgctttttc tgtatcaaat ttgtaatttc catcctcgag 1460581 atacacacat tgtgaaacaa tgctgaaaaa ttctgatgtc gattcccaga gtgtagcaat 1460641 tacctgagcc tcttcttttg tcattcctaa ctcgacagct ttttcgctgt caaaataata 1460701 tacaccgtct tgttcgtata tacattgatt taatatatca atgaatgtat tgagatcttc 1460761 gttagtgctc gcctgatgct ggagttgaac agcagtgtta tcaaccggtg tttttgcgct 1460821 ggctgcatca ggaccgaacg ttaatagagc agctgaggtc attgcggcag tcgttaacat 1460881 agcttttttt acaaatgttt tcttcatgtt tcttctctcc cttttatgaa ttgtgctaca 1460941 aattccatta tagggagtag tttccggtgg aggaataggc gctatggtat tttatgtgta 1461001 tcgttgccga actacttttt gaaggctgca cgtgtgatcg ttagaacgat tgtctatgta 1461061 tgaaggctgt tttgcatctt cctgactaag aaacagggga gataaggctt aaagaaatga 1461121 aaaacaccgc tttctttgcg gtgttttttg attacaatgt cgccggcggg gcaatgcttt 1461181 taatcaagca agccttgttc gcgcattttc ttttttaatg taaatccgcc gcccatgaca 1461241 gcgcaaacaa gtacaatgct ggcgataatg cctgcagggc ttttttcagc gataaagacg 1461301 ccgatcagca taatgctgaa aaccgctgca aatgcaaata atagtaaaag ccaattcatt 1461361 tttttcataa attccatccc cttttacgtc ttatattaag tttacagaaa aacgtgacgc 1461421 ttttaaagag gatgtgtgat ataatatgaa agttatctaa tttttttagg agatgaaaaa 1461481 gtgaaacttc gaaatgatct tcgcaacatc gcgattattg cccacgttga ccatgggaaa 1461541 acgactctag tcgatcagct tttacatcag gctggtacgt tccgtgccaa cgaacaggtt 1461601 gctgaacgcg caatggactc taatgatctt gaacgcgaac gcggcattac aatattggcg 1461661 aaaaatactg cgattaacta taaagataca cgtatcaata ttttggacac ccctggacat 1461721 gcagactttg ggggagaagt agaacggatt atgaaaatgg ttgacggcgt agtgcttgtc 1461781 gttgacgcat atgaaggctg tatgcctcaa actcgttttg ttctgaaaaa agctcttgag 1461841 caaaacctga accctgttgt tgttgtaaac aaaattgacc gtgactttgc tcgtccagag 1461901 gaagttatcg atgaagttct ggatctgttc attgagcttg atgccaatga agagcagctc 1461961 gagttcccag tggtatatgc ttccgcgatt aatggaacag cgagtcttga tccgaaacaa 1462021 caggatgaaa acatggaagc tttatatgaa accattatta agcatgttcc ggcacctgtt 1462081 gataatgcag aggagccgct tcaattccaa gttgcccttc ttgactacaa cgactatgta 1462141 ggccgtatcg gaatcggacg cgtattccgc ggcacaatga aagtcggaca gcaggtttct 1462201 cttatgaagc ttgacggaac ggcaaagtca ttccgtgtta caaagatttt tggtttccaa 1462261 ggcttaaagc gtgtggaaat tgaagaagca aaagcgggag acctcgttgc ggtttccggg 1462321 atggaagata tcaacgttgg tgaaacggta tgtcctgtag accatcaaga tccgcttccg 1462381 gtccttcgca ttgatgagcc gacacttcaa atgacatttg tcgtgaataa cagtccgttt 1462441 gcaggccgtg aaggcaaata tgtaacggcc cgcaaaatcg aagagcgtct tcaatcacag 1462501 cttcagacgg atgtgagctt gcgtgttgag ccaacagctt ctcctgatgc ttgggttgtt 1462561 tcaggacgcg gtgagctgca cttgtcaatt ttaattgaaa atatgcgtcg tgagggctat 1462621 gagcttcaag tgtcaaaacc tgaagttatt atcaaagaaa tcgacggcgt acgctgtgag 1462681 cctgttgaac gtgtgcaaat tgatgttcct gaagagcata ctggctctgt aatggaatca 1462741 atgggtgccc gcaaaggcga aatggttgat atgatcaaca acggaaacgg ccaagtccgt 1462801 ctcatcttta cagttccttc ccgcggattg atcggttact ctacagaatt cctatcatta 1462861 acacgcggat tcggtatttt gaaccatacg tttgacagct accagccgat gcaggcaggc 1462921 caagtcggcg gacgccgtca aggtgtactt gtgtcaatgg aaaacggaaa agcaacatca 1462981 tacggtattc aaggaattga agaccgcggt gtcatcttcg ttgagccggg tactgaagta 1463041 tacgaaggaa tgatcgttgg agagcataac cgtgacaacg accttgttgt taacgtcagc 1463101 aaaatgaaac agcaaacaaa cgtccgttct gcgacaaagg atcagacaac tacaattaaa 1463161 aaagcgcgca tcatgtctct tgaggagtct ctagagtact taaacgaaga tgaatattgt 1463221 gaagtaacac ctgaatccat ccgtttaaga aagaagatcc tcaataagaa cgaacgtgaa 1463281 aaagcagcta aaaagaaaaa aacagcagga ttgtcttaat ctcgtgcaga atttgaaaag 1463341 atagaacccg tacgtttaca ggggagggaa tctttttgaa tgacgtaagc gaacgcctgt 1463401 cgttcttcgc cgctctatat caagtagacc ggcagcctgc ggcaggcatg tggctgctgt 1463461 acggcacgat ttttgtgttg gccgttattg tatttaagct tggatttgct aaacggcttc 1463521 ctgtattaaa atctgcagtg gtgtatgtat ttttggcttt gggctgcact gttttgactt 1463581 ttttaggggt gtttttgccc gtggcagaag gattggtcgt cgctgcgctg attttaatca 1463641 tttacaaaat ccggctgtat cagtcgaaaa aaggacagtc tgcaaaatca taaaagactc 1463701 agctgaaagc tgagtctttt ttgtgttctg tatggttaag cggccgcttt attttttgac 1463761 tttttctttt ttctgctgtc ccgggtgaaa agtaaatttt cccgttttca gccgttcctc 1463821 tgtttttttg gcaatccgat cgtggcattc ctggcacata tatgtatgga tcgggcggtt 1463881 tcgaagccgt ttcgcgatca gggtatcatc atcaattgtt tcaattttat cgcaaataga 1463941 acatttgacc ctcatcatat cacctctttc actaacatgt attataccac ggatcagaag 1464001 ctgtccaaaa taagaaaaag ctaaagcgca aggctatagc ttagtcattg ttgttctttt 1464061 tcatatgatg atcagattga tcgttttgtt ccttctccat ttcctgttgc tgttttctat 1464121 ttaattggtc attttgctgc tttgtttgcg gttcatcttc attgtcaatc acatcgttag 1464181 gcacttcggg aagcactcgg ccgacaattg cagctaattc atccagtata cctgttaccg 1464241 gatggccctc gctgatttct ctgctcattt cgcgaaggcg gctgaccgta tcgggatcag 1464301 caatgactac tgcgttggcg ccatatcgat cattctttag cgcctgagct acagaatatt 1464361 taatggtttc cactttgctt ctgtccaaag tatcatcgac atcaatccca acaacagcat 1464421 agcctcccag cacaacggct gttgcatcct tgacgtcggg gtttttttca gcaacgctga 1464481 caagatgctt ggcaatatcc gttcttgttc cattgtcttt tgtttcttga gttgtgtcct 1464541 ttacgtgaat cggtttagtc tcctgctgtc ttgttgattc tttttcaaca ttctggccct 1464601 gttttccttg ttgataggca caagcggaca ggataagtgt cagctgtatg ataatgaaaa 1464661 gaattcgcac ttgcgggttc cctccttaaa atgctttcat taattttatt gttgaattaa 1464721 ccttctatct ttatgcacaa aaacatatat tttagcaggc attcaccttt ttcatcaaaa 1464781 gagaagcagg aagaactttg acccttatat caggaggctg agacttgagt aaaatttatg 1464841 tgttagatac gaatgtgtta ttacaggatc ctaacgcgat attttctttt gaagaaaatg 1464901 aggttgtcat ccctgctgtc gttttagaag aggttgattc aaaaaaacgg tatatggacg 1464961 aagttgggag gaatgcaagg cacgtatcta agctaatcga tgcgctaaga caaaagggca 1465021 ggctgcatga gcatgtaccg cttgacaccg gcggcacact gagaattgaa ctgaatcatc 1465081 gttcgtttca ccagctgcaa gagatcttta ttgaaaagac gaacgataat cgcatattag 1465141 ccgttgcgaa aaacttaagc ctcgaggaag aaaccaagga aaatggcagg ccggttatcc 1465201 ttgtcagtaa ggatgtactg gtcagggtta aagccgacgc aatcggactg cttgctgaag 1465261 atttcttgaa tgaccgggtt gtggacaatg atgaaatgta cagcggctat aaagatttat 1465321 atatcagcca gcagctgttc agctcttttt acgggaaaaa tcaaatttca gtaaacgatg 1465381 tgaaacagca tgcgttttat ccgaatcagt ttgctttaat gaaggatgag ctaggagggt 1465441 cctcctcggc agtcggaatt gcagacaaaa ccggaacggt attaaaaaga ctcgtatttg 1465501 atgatgaaca tatatgggga atcaggccga aaaatgtaca gcagacaatg gcattagagc 1465561 ttttgctgcg ggaagatatt ccgcttgtca ccctgatcgg caaagcggga accggcaaaa 1465621 cgctcttagc tttggcggca gggctattac agacagaaga cttgggaata tataaaaagc 1465681 tggtcgtcgc aaggccgatt gttcctgttg gcaaggacat cgggtatttg ccaggcgaaa 1465741 aagaggaaaa gctaaagcct tggatgcagc cgatttttga caacttagag tttctgttta 1465801 atgcgaaaaa accaggggag cttgatgcta ttttggcggg aattggctca attcaggtag 1465861 aggcgctgac ttatatcaga gggagaagca ttccagatca atttattatc attgatgaag 1465921 cgcaaaattt gaccaggcat gaggtgaaaa cgttgctgac gagagtcggt gagggcagta 1465981 aaattgtctt aatgggcgac cctgaacaaa ttgatcaccc atatttagac agtctgaaca 1466041 atggtttggc ctatgtggtt gagcggttta aaggacaacc catctcaggc agcgtgaagc 1466101 tgttaaaagg tgagagatca ggtctcgccc agcttgcagc tgatttgctg taacacttaa 1466161 atgatttcga tctcttttac atcggtaatc ggctgtttgt gatgaaccgg gtcttcaaag 1466221 taaatatgca cggggccgcc ttcttgaatc ggcttgcctg cctcactgaa atggacaata 1466281 ctgttcagag cggtttccag agaaacggcg gcctttcccg aacttgtgac aaatacacat 1466341 tgtgtcgcag agctgttcgg ctcagcattt ttcaggacag tcccaagtct cattgcgaaa 1466401 ctgccgttca tcagtttttg cttctcatat tgcttttccg tctttaatgt aggcggcgcg 1466461 attcgcccct ctctgatgac gcgttccgga tcaaggtcgg attcatcccc ggctgattgt 1466521 aaatatgtgt cttgactgtc ccctttgcgg tcaaacgaaa atttgcgatc atcaaaaatc 1466581 catacgcttg gatcaatggt aattggatat gtaacattgc cttttacttg gataacgctc 1466641 atgatatgac ccccttctct caaaattata aaagttttcg catgaattgt cactttgtgt 1466701 acaaattatg tgtattgaaa tgctgaggga acgagggtgt ttgcatggta tgccagcata 1466761 atgatgagct tgaagcctta gtgaaaaagg cgaaaaaagt aacggacaag ggggaggtag 1466821 ccagctatat tcccgccttg gcaaaagctg ataaacacga cctgtcagtg gcgatttatt 1466881 attccaataa tgtttgtctg tcagcaggtg acgtagaaaa aacatttacg cttcaaagta 1466941 tatcgaaagt cctttccctt gctttggtgt taatggaata cggcaaagat aaggtcttca 1467001 gttatgttgg acaggagccg accggtgatc cgtttaattc aattatcaag ctcgaaacag 1467061 tgaatccgag caagccgtta aaccctatga ttaatgccgg ggcattggta gtgacaagtc 1467121 tgataagggg aagaacggta aaagagagac ttgattattt gctttctttt atcagaaggc 1467181 tgacaaacaa ccaagagatt acatactgcc gggaagtggc tgaatctgaa tacagcactt 1467241 caatgattaa tcgggcgatg tgttattata tgaagcagta cggcattttt gaagatgatg 1467301 tagaggcagt aatggattta tatacgaagc aatgcgcgat tgagatgaac agcttggatt 1467361 tagcgaaaat cggatctgta ttcgcattga acggcagaca tccagagact ggggagcagg 1467421 tcatctcaaa agatgtcgct agaatttgca aaacgtttat ggtgacgtgc ggaatgtaca 1467481 atgcaagcgg ggaattcgca attaaggtcg gaattcctgc gaaaagcggc gtatccggcg 1467541 ggataatggg catttcgcct tacgatttcg ggatcggcat attcggcccc gcattagacg 1467601 aaaaagggaa cagcattgca ggtgtaaagc ttttggaaat aatgtctgag atgtacaggc 1467661 tgagtatttt ttaatttatg tcatatgctt aaatcctctt gcattttctg ttgataccct 1467721 ttatgataaa tagaagaatt aggtactcgc ctggggaacg gagggatact tttggcttca 1467781 gagatgatag ttgaccatcg gcaaaaagct tttgaactct taaaagtgga cgctgagaag 1467841 attttgaagc tgatccgagt acaaatggat aacttaacga tgcctcaatg tcctctatat 1467901 gaagaggttt tagatactca aatgttcggg ctttcgaggg aaatcgattt tgctgtccgc 1467961 ctgggattgg ttgatgaaaa agacggtaaa gaccttttat acacattgga gcgcgaattg 1468021 tctgctttgc atgacgcgtt tacagctaaa taaatgataa aactcaaact tattaacagt 1468081 ttgggttttt ttataaccgc tatttttctc tcatctcata aaagacggtc tttttttaca 1468141 cattccttcc gaatcgtata gagattcttc gtctcgtttg ataaattgta gtaaaataaa 1468201 aaagataaat acataaaaac catagataat ggaagttaga agcagggaag aggatgttat 1468261 gttaaaaaaa atgctaaaat cttatgatta ctcactgata ttcgcaatcg ttttattatg 1468321 cggattcggt ttagtgatgg tatacagctc aagcatgatt acggctgtct cccggtatgg 1468381 agtaagcagt aattttttct tcatgcggca gctgtttgct ttaattgcgg gtggcgctct 1468441 atttattctc atggcgttgt ttccttataa agcactggcc catcaaaagt ttcagaaggg 1468501 gatactgctt gtatctgttc ttgcgcttat ctcactgttt gttttcgggc atgttgccgg 1468561 aaacgcgcag agctggttta aaatcggcgg aatgagtatt cagccggggg agtttgtgaa 1468621 actggtcgtg attttatacc ttgcagccgt atatgcaaaa aaacaaagtt atatcgacca 1468681 tctgttaacg ggagtagccc ctccggtagt catgacgctt ataatttgtg ggttaattgc 1468741 catgcagcca gatttcggta cagccatgat tatagggtta attgcgacgt gcatgatctt 1468801 gtgctccggc ttcagcggaa agacgctggt gaggcttgtg atactgggcg gaattgtttt 1468861 cattttagtc agccctatta tctatttgaa tcaggacaaa attttaactg aaggccgttt 1468921 agcgcgtttt gagagtcttg aagacccatt taagtatgca aattcatcag gtttgcaagt 1468981 gatcaattct tattatgcga tcagctcagg cggcattttc ggcctggggc tcggtgaaag 1469041 tatccaaaaa tacggatatc tgcctgaatc acacactgac tttattatgg ctgtcattgc 1469101 tgaagagctc ggcatttttg gggtattgtt tgtgattttc ttattgggtt ttgtcgtcat 1469161 aaaaggtttt tatattgcca gaaaatgcga ggacccgttt ggaagtcttc tggcgatcgg 1469221 catttcaagc atgattgcca tccagtcgtt tattaacctt ggcggtgtca gcggattaat 1469281 tccgattaca ggggttacgc tgccatttat cagttacggg ggctcttctt tggtgctgct 1469341 gctggggagt atggggatat tagcgaatat cagcatgttt gtgaaatatt cagagaataa 1469401 gaaaaagaaa gagcccttgg cgccgaaggg aatgaaaaag aaacagctca aaaaaactgt 1469461 ttatctgtaa aaaacaagtg tgtacagggg aaggatattc cgctatgata gattatattc 1469521 cattcgggta agggggagaa aagtttgtct cagcaatcga tacaaaaagt attagtagca 1469581 aacaggggag aaattgcaat ccgaatattc cgggcgtgta ccgagttgaa tattcgtaca 1469641 gttgcggtct attcaaaaga agattccggt tcctaccatc ggtacaaagc ggatgaagca 1469701 tacttggtcg gtgaagggaa aaaaccgatt gatgcttacc tggatattga aggtatcatt 1469761 gatattgcga aaagaaacaa agtcgatgca attcatccgg gatacggttt cttatctgaa 1469821 aatattcatt ttgcgagacg atgtgaagaa gaaggcatcg tattcatagg gccaaaatcc 1469881 gagcatctcg atatgtttgg tgacaaggta aaagcgcgtg agcaggcaga aaaagcggga 1469941 atccccgtga ttccgggaag cgacggtcct gccgaaacgc ttgaagccgt cgaacaattt 1470001 ggacaagcta acggttatcc gatcatcatt aaagcctcgc ttggcggcgg cggccgcggt 1470061 atgcggattg tcagatctga aagtgaagtt aaagaagcat atgagcgtgc taaatcagag 1470121 gcgaaagcag cctttggcaa tgatgaagtt tatgtagaaa aattaattga gaatccgaaa 1470181 catattgagg ttcaggtcat tggagacaag cagggcaatg tcgtccatct ttttgagagg 1470241 gattgctccg ttcaaagacg ccatcaaaaa gtcattgaag tggcgccgag tgtctcgctg 1470301 tcacctgaat taagggacca aatttgtgag gctgcagttg cgcttgccaa aaatgtaaac 1470361 tatataaatg cggggacggt cgaattcctt gttgcaaaca acgagttcta ctttattgaa 1470421 gtaaatcctc gcgtacaagt tgaacacacg ataacagaaa tgattactgg tgtcgatatt 1470481 gttcaaactc agatccttgt tgcccaaggg cacagccttc acagcaaaaa agtaaatatt 1470541 cctgagcaaa aggacatttt tacaatcggc tatgccattc agtcacgggt tacgactgag 1470601 gatccgcaaa atgatttcat gcctgataca ggaaaaatca tggcttaccg ctcaggcggc 1470661 ggttttggtg tccgtcttga taccggaaac agcttccagg gcgccgtgat cacaccatac 1470721 tatgattcac ttctcgttaa gctttcaact tgggctttaa cgtttgaaca ggcagctgcc 1470781 aaaatggtgc gaaaccttca ggagtttaga atcagaggca taaaaacgaa cattccgttc 1470841 cttgagaacg ttgcaaagca tgagaagttc ctgacagggc aatatgatac atctttcatt 1470901 gatacaacgc ctgaattatt taatttccct aaacaaaaag accgcggaac gaaaatgctc 1470961 acttacatcg gcaatgtgac agtgaacggc ttccctggaa tcgggaaaaa agaaaaaccg 1471021 gcgtttgaca aaccgttagg cgtaaaggta gacgttgatc agcagcctgc cagaggaaca 1471081 aagcaaattc tcgatgaaaa aggtgcagaa gggcttgcaa attgggttaa ggagcagaaa 1471141 tctgtccttt taactgatac gacattcagg gatgcccacc aatcgttatt ggcaactaga 1471201 atcagatcgc atgatttgaa aaaaatcgca aatccgacgg ctgcgttatg gcctgaacta 1471261 ttcagtatgg aaatgtgggg aggcgcgacc ttcgatgtag cctaccgatt cctgaaagaa 1471321 gatccgtgga aacgtttgga agatcttcgc aaagaagtgc cgaatacctt attccagatg 1471381 ttgcttcgct catcaaatgc ggtcggctat acgaattatc cggacaatgt gattaaagaa 1471441 tttgtgaagc aatcagctca atccggtatt gatgtgtttc gtattttcga cagcttaaac 1471501 tgggtaaaag ggatgacgtt agccattgat gctgttaggg ataccggcaa agtggcagaa 1471561 gctgcgattt gttatacggg agatatcctt gacaagaacc ggacgaagta cgaccttgca 1471621 tattatacat cgatggcgaa ggagcttgag gcggccggag cccatattct cgggattaaa 1471681 gatatggcag ggctgttaaa accgcaggct gcatatgagc tcgtttctgc gttgaaagaa 1471741 acgatcgaca ttccggttca ccttcatacg catgatacga gcggaaacgg tatttatatg 1471801 tatgcgaaag ctgttgaagc cggcgttgat atcatagacg tggcggtcag ctcaatggcg 1471861 ggattaacgt cacagcctag cgcgagcgga ttttatcatg cgatggaagg caacgaccgc 1471921 cgtccggaaa tgaatgtcca aggcgttgaa ttgctgtccc aatattggga gtcggtgcgt 1471981 aaatattata gtgaatttga aagcggaatg aagtctccgc atactgaaat ttatgaacac 1472041 gaaatgccag ggggccaata cagcaacctg cagcagcaag ccaagggagt aggccttggc 1472101 gaccgctgga acgaagtcaa ggaaatgtac agacgcgtga acgatatgtt cggtgacatc 1472161 gtcaaggtaa cgccttcctc aaaagtagtc ggagatatgg cactctacat ggtgcaaaac 1472221 aatctgactg aaaaagacgt ttacgaaaaa ggtgaatctt tagatttccc tgattctgtc 1472281 gtggagcttt ttaaaggaaa tatcggccag cctcatggcg gattcccaga aaaactgcaa 1472341 aagctgatct taaaagggca ggagccgatt acagtcagac cgggcgaact gcttgagccg 1472401 gtgtcatttg aagcgatcaa acaggaattt aaagagcagc ataacttgga aatttcagat 1472461 caggatgctg tggcatatgc cctttatcct aaagtcttca ctgattatgt gaaaacgaca 1472521 gaaagctatg gagacatctc ggtattagat acaccgacat tcttctacgg tatgacatta 1472581 ggtgaagaga tagaagttga aattgagcgc ggcaaaacgc tgatcgttaa gctgatttca 1472641 atcggtgagc ctcagcctga tgccacccgc gtcgtttatt tcgaactcaa cgggcagccg 1472701 cgtgaagtag tcattaaaga tgaaagcatt aagtcttccg ttcaggaaag gctgaaagca 1472761 gaccggacaa atccaagcca catcgcagct tccatgcctg gaacagttat taaggtattg 1472821 gctgaagcag gcacaaaagt caataaaggt gatcatttga tgattaatga agcgatgaaa 1472881 atggaaacaa cggttcaggc gcctttctca ggaacaatca agcaggttca tgtgaaaaat 1472941 ggtgagccga tccaaacggg agatctgctc cttgaaattg aaaaagcata aaaaacaaag 1473001 agtgtatatc aatgatatac actcttgttt tttatataga aaatgtggag tgaaacagat 1473061 ggttagaaga gatataaggg gacttcagag attatagagt actgtcacaa gcccaaaata 1473121 aaaagaggct tatacagcca atattttaga tgctttgtag tatgccgtgc atatttcttt 1473181 aagcactatc tgatttaaaa ggctttaata cttatgttcg cgagctatag atccatatga 1473241 aatttctata atcacgatga gaaaggggac agaccgaagt gagccgctca ctgatcatca 1473301 agttcggcga aggctggcga ttgaaacgca taaagcgcca aaaaacaaga cataaaaaag 1473361 accaaagccg cctaaggctt tggtcttgag tccttatgat tgcctggatt cataacggaa 1473421 acgagcaatc aataataaga agtagcatag aacgccaaac agacaggcaa taaagaacga 1473481 gtgggcaagt gcaaagccca gagccagttc agagtatacg atcataatac cggacagtgc 1473541 ctgtaatgta atgaaaataa gacatgagat ccatccccaa aagatctgtt tttgatcttt 1473601 ataggaagta atagcatgaa cagcggcaac aataatccat acaaataaaa gtaaggctgc 1473661 tgctctgtgg cccatttgca cccattcatg gaattgggtc ggaagtccat tgttcagcgg 1473721 gctgcacagc ggcacattag gacatgccag acttgattca gtgtgtctta catatgcgcc 1473781 tgtatacaca acgatatagg aatatattaa aattcctatc atgtgaaatt gcatcttttt 1473841 gccgatttga agcggcttaa ccagtgttct gactgattta tcagcttcaa atatgagcaa 1473901 tgttaaaata agcactgaag caaaagaaat taatgagatg ccgaagtgaa gcgccataat 1473961 cagcgcgttc gaaccgaata cgacagccaa tgcgccaagc aatgcctgaa gaaataaaaa 1474021 gataattgac atgatcgcga gaaacgttgt ttcacgaaaa atcggcgtga tttttctcca 1474081 tgaccaaaac gcaaggctta gcacaaggat aatagagatt ccgcttgcga atcggtggct 1474141 ccattcaata attgaagccg gattcagttc agggaaaaaa cggccgtgac acagcggcca 1474201 ctgtctgccg catccttggc cggaacctgt ttttgtaacg agggcacccc cgattaaaac 1474261 aattagcatg acaaatgtcg tcagaacacc gagagctttt aatgctttat tcatacaata 1474321 ttcaccttct taacatactg ctgcaatttt atatacgttc caagtgtaag cgaatatgtg 1474381 ttttgtggca attcccagag ccttttgttc acaaaaatat aatagaatga cggcttctgg 1474441 aaaatgtaca cttgattatt catgccgggt ctgatagaaa taaggtaaac gcaatgccga 1474501 tttggagatt gccttcatct ttggtaaaat tcataaaaag ttcacaaata aattcctgtt 1474561 tgtcgtttaa tatttaatag gatgtttttt tacaagatgt tatcttgtat gatagagttg 1474621 caggttattt tattctcctg cgttaggttt gtaagggagg tttacgttat ggctaactcc 1474681 agaatcttaa atgatacagc tatagacgga caaattgaag aaacaacggc atggaaagat 1474741 tttctgtccc ttattaaaat agggatcgtc aattctaacc tcatcacgac tttcactgga 1474801 atgtggcttg cactgcatat atccggttta agttttttag gcaatataaa caccgttctt 1474861 cttacgttaa tcgggtcttc actgattatt gcgggctcct gcgcgatcaa taactggtat 1474921 gaccgggaca ttgaccatct tatggagcgt acgaaagtaa gaccgacggt tacgggtaaa 1474981 attcagccga gtcaggcgtt atggtctgga attttgctgg ttgctttagg attgatcatg 1475041 ctgctgatga caactgtcat ggctgctgtt atcggtttta tcggagtctt tacgtatgtt 1475101 gtattgtaca caatgtggac gaaacgccgc tatacgatta acacagtagt aggaagcgtt 1475161 tccggtgcag tgccgccgct tattggatgg acggcagtgg aagggaatat cggtgtcgta 1475221 gcatgggtgt tattcatgat tttatttatt tggcagattc ctcacttctt agcattggct 1475281 attaagaaaa ctgaggatta cagagctgca aatattccga tgcttcctgt cgtatacgga 1475341 tttgaagtga caaaaagaca aattattgtg tgggttgcgt gcctgatgcc gcttccgttt 1475401 ttccttggta gcctgggtct tccgattgtc attctcggct tgctgttaaa tatcggctgg 1475461 ctgattcttg gcttaatggg attccgctcc aagaatatca tgaagtgggc aacgcagatg 1475521 ttcgtttact cgcttaacta catgacaatc tatttcgttg ccatggttgt cttgacgctt 1475581 ttctaaaaaa tagatatgat gcttgtttta tcgcttcaaa ataaacgatg acaactagta 1475641 aatgccgcct tgacctcttg tttaatcagg cggctttact tttatacata gatggcattt 1475701 tgagtaaaaa aactcataat ttaagagaag aggaaatgta agtgctttat tggtgatagg 1475761 ttggatggcg atagatttcg atccgctttc cgcctttgta ttgaccagaa aaggggttgg 1475821 gtgaaatggt aaagcattgg cgtcttattt tattattagc cttagtgccg cttctattaa 1475881 gcggatgtgg aaaacctttt ttatccacgc tcaagcctgc tggcgaggtg gctgataaac 1475941 agtatgacct gacagtgctc agcacattga ttatggtggt tgttgttgca gtagtatctg 1476001 ttatcttctt ttatgtgatt gtgagattca gaagatcacg ggtcggtgag aacacgatac 1476061 cgaaacaggt agaggggaat aaatttttag aaatcacatg gaccgtgatc ccgattttgc 1476121 tgctcattat tcttgtgatt cctgttgtat tatatacgct ggagctagcg gacacatcac 1476181 caatggataa aaaaggccgc aaagctgagg atgctcttgt agtcaatgtt agggcaaatt 1476241 tatactggtg ggagtttgag taccctgatt acggcattat cacaagccag gagctgattg 1476301 taccgacaga tcagcgtgta tattttaatt taaaagcctc tgatgtaaaa cattccttct 1476361 ggattccttc agttggagga aaacttgata cgaatacgga taatgaaaat aagttcttcc 1476421 tgacatttga ttcaaaacga agcaaagagg caggagatat gttttttggg aagtgtgcag 1476481 agctttgcgg cccttcacat gcgctgatgg attttaaggt gaagacgatg tctgcaaaag 1476541 aatttcaggg ctggacaaaa gaaatgaaga actataagtc tacagcagag agcgatttgg 1476601 ctaagcaggg tgaagaactg tttaaagaga aaaactgcct gagctgccat gcggtagagc 1476661 cgaatgataa gcgtgcagaa gccgctagaa cggcacctaa cttggcgacc ttcggtgaaa 1476721 ggacaaaagt ggcaggggtg aaagaggcca acaaagaaaa tgtgaaggct tggctgaagg 1476781 accctgacag cataaagccg gggaacaaaa tgacaggcac atatccaaag ctctcagaca 1476841 gcgaaacaaa tgcgctttat gaatacttaa aaggcttaaa agcggaaagc aagtagggaa 1476901 gaaagggaga tattggggga ggtcacatat gttgaatgcg cttacagaaa agcggacgcg 1476961 cggatctatg ctttgggatt atttgacgac ggtggaccat aaaaaaatcg caattcttta 1477021 tttagtggca gggggattct tctttcttgt cgggggaatt gaagcgatgt ttatcagaat 1477081 tcagcttgca aagccggaaa atgcgtttct cagtgctcaa gcgtacaatg aagtaatgac 1477141 tatgcacgga acgacgatga tctttctggc tgcgatgccg ctcttatttg ccttgatgaa 1477201 tgcggttgtg cctttgcaga tcggggctcg ggacgtttcg tttccatttt taaacgcgct 1477261 tggtttttgg ctcttctttt tcgggggcat tttcttaaat ctaagctggt ttttgggcgg 1477321 agcgccagat gcgggctgga catcatatgc ctcactttcg cttcattcta aagggcacgg 1477381 catagacttt ttcgtcctcg gactccaaat atcggggctc gggacgctga tagccgggat 1477441 taactttttg gccacgatta tcaacatgag ggctccgggc atgacgtata tgaggctgcc 1477501 tttgtttaca tggacgacat ttgtggcctc ggcattgatt ttgttcgcgt ttccgccgct 1477561 tacggttgga ttggctctca tgatgctgga tcggctgttc ggaaccaatt tctttaatcc 1477621 ggagcttggc ggaaatacgg tcatttggga acatttattt tggatcttcg gccacccgga 1477681 ggtttatatc ctaattttgc ctgcattcgg tattttttct gaggtcatcc ctgtgttcgc 1477741 cagaaagcgt ttgtttggct attcttcaat ggtttttgca atcgtgctca ttggctttct 1477801 gggctttatg gtttgggtgc accacatgtt cacgactggt ctcggcccga ttgcaaatgc 1477861 gatttttgcg gttgcaacaa tggctatcgc gattccgacc gggattaaga tttttaactg 1477921 gctgttgacg atttggggag gaaatgtgaa gtatacaacc gctatgctgt atgctgtctc 1477981 atttattcca tcctttgtgc tcggcggtgt gacgggagtc atgctggcag ctgctgcggc 1478041 tgattatcag tttcatgata cgtattttgt ggttgcgcac ttccactacg tcattattgg 1478101 cggcgttgta ttcggccttt tagccggtgt tcatttctgg tggccgaaaa tgttcggtaa 1478161 aattctgcat gaaacgatgg ggaaaatttc atttgtattg ttttttatcg gctttcacct 1478221 cacgtttttc attcagcatt ttgtcggctt aatggggatg ccgcgccggg tttatacgtt 1478281 tttgccagga cagggtctgg aaaccggcaa cttgatcagt acaatcgggg cgttttttat 1478341 ggcggcagct gttattcttc tgctggtcaa tgtcatatgg acatcggtaa aaggtgaata 1478401 tgtaggtgct gatccatggc atgacggacg tacgctggaa tggaccgttt cttcaccgcc 1478461 gccggagtat aactttaaac agcttccttt tgtcagagga cttgatccgc tttggatcga 1478521 gaagcaggca gggcacaaat caatgacgcc ggcggaaccg gttgatgata ttcatatgcc 1478581 aaacggctca atcctgccgc tcatcatttc cttcggcctt tttgtcgcag cgttcgggct 1478641 gctgtacaga agtgattacg cttggggcct gccggtgatc tttatcgggc tcggcatcac 1478701 atttattacg atgctgcttc gttcagtaat tgatgatcac ggctatcata ttcataaaga 1478761 ggaactgccg aacgatgata aaggggtgaa ggcataatgc aagttcaaga aaaattcacc 1478821 gcagaaacct ttccagcttc tcctgaaaaa gtaaccctgg aagggaaaaa taaattttta 1478881 ggcttttggc tttttcttgg cggagagact gttctgtttg cgtctctctt cgccacgttt 1478941 cttgcgcttc ggaattcaaa tgccggtgat ccgcctacga cggaaatgtt cgatgtgaca 1479001 cttgtattca ttgccacaat gcttctatta acgagcagtt taacgagtgt gtacgcgatg 1479061 taccacatga agaacttttc cttcggcaag atgcagcttt ggctgggaat tacgatttta 1479121 ttgggggcgg gctttttagg actggaaatc tatgagttca agcattacac ccatgaattt 1479181 ggctttacca tcacaagctc tgcccttggt tctgcgtttt acacgcttgt cggtacacac 1479241 ggcgcccacg tggcatttgg gcttatgtgg atcagcacgc ttatgatccg caatgccaag 1479301 agagggctga atctgtatac ggcgcctaag ttttacgttg ccagccttta ttggcacttt 1479361 attgatgtcg tgtgggtctt catctttacc gttgtatatt taatggggat ggtgggataa 1479421 acatggtcga taaaaaaagc agagggcata tcaatagcga ccttgaattt aagaaaaaaa 1479481 agcatgcccg ggagatgaaa tatcaagtcc tgtcttttgg tttaatgatc ggtcttacga 1479541 ttgttgcatt tctgactgtg gccacggacg gtgtcggcag ctggtttacg attcctttca 1479601 ttattttgct agctgcaatt caagtcattt ttcagctgta ttatttcatg catatgaatc 1479661 agaaagggca tgaggcgccg gcactgtttt tgtattcagg ggtgtttgtc gcgtttatca 1479721 ctgtgcttgc gtttgtgaca attatatggt ggtaatttga acagccgccg gaggtgaaga 1479781 aatgaatcag ttggagatat ttgggtttcg cgcgatgtgg agcccttatc ttttttgtat 1479841 cctgttaggc attacggcgc tttatctcta tttttacagg cgaatgtctt caaagccgaa 1479901 tcgaataact ggtaaagaga tggtgtgctt tctgtcggcg atgctgtttt tatatgcagc 1479961 cgagggaagc ccggttgatc tgctcggaca tattatgttc agtgcgcata tggtgcagat 1480021 ggccgtcctg tatttggttg tcccgccgct gttaatcgcg gggattcctg catggctctg 1480081 ggaaaaaatc attttcaggc cttcaatcaa accggttttt tcctttttta cgacgccttt 1480141 aattgctttg cttttgttta acggcatttt ttctttatat catgtaccgc ttatatttga 1480201 tactgtcaaa acagatccgt tttaccatac attaatcact tggcttatct ttgtgcttgc 1480261 gttcttcatg tggtggccgc ttgttcataa ggttgagcgt ctacggcagc tcagcggctt 1480321 gatgaagctg ggttatatta tggcggacgg tatgctgctc acacctgctt gcgccttgat 1480381 catgttcagc ggtgcaccgt tatacgccac ctatacagat ccggctttat gggctgaggc 1480441 aatgaggctt tgcgtgccag cggatatgat ggggcaggtc ccattaacag ggccagagat 1480501 gttgaataca ctgcctttgt tagaggatca gcagctcgga gcagtcatga tgaaaatcat 1480561 tcaggaaatt gtgtacggta cttttttggc cgttattttt ttccaatggg tgaagaaaga 1480621 aagggaaaag gacgggcagg aggagccgcc gtatattcag cagacgatat cataaaaggt 1480681 acagcgaaat atgctgtacc ttttcgttac atttgaactg tttttaacat gttggctatg 1480741 tcctgaatca gtgccttgct ttttgtcaca acctgtacgg gaaactcttc cgtttctcca 1480801 tattctactc catgagggta gtaatgcttt cctaggagag gggacattaa ttgaatcacg 1480861 gcgcgcccgc ttccgacatc gccttctgcc gcaatacctt gtatccgcag gtaaaacgta 1480921 ccctcaatcg tcgaaaactt cttgtcatag gtgactctct cgtaatccca ttgacccgct 1480981 ctgataagac ctttgctttc cattaagtcg tctagccagc tgagctcagc cttaacccct 1481041 tcaagtccgc tttcagtaaa cttcaacact gacccctcct tataaaaatt acctttcctg 1481101 acaatcatag tatgaaagcg ttaaactttc aatgaatctt cttcttttga aagtatgcaa 1481161 aaattaaatt ttgacgacaa tagcactaga ctaaaggagg ttaaacggat gacaaaaata 1481221 aaagatctga tgacagccga cttgcaatat tgcacggtat tagataatgt atatgaagct 1481281 gcagtaaaga tgaaggacgc aaatgtagga gcgataccgg tagttgatga ggacggggaa 1481341 acattggtcg gcatcgtaac cgaccgcgat ctcgtattaa gaggaatcgc catcaaaaaa 1481401 ccgaactcgc aaaaaatcac tgacgcgatg actgaaaaac ctgtcagtgt ggaggaagat 1481461 gcttcagtcg atgaggttct tcatttgatg gcatcgcatc agctcagaag gataccagtt 1481521 acaaaaaata aaaaactgac tggaattgtc acgcttggtg atctttcttt atctgagcaa 1481581 acgaatgaac gtgccggcag cgccttatcg gatatttccg aaggggataa tagagaagaa 1481641 ggcttttttc attaacacat aaatctttga catgttaaat aggctgtatt gtaatgggat 1481701 gtaaacaaga gattgtgaat cgccacgggg gtgatagatt gaaaaatata ttgagagcaa 1481761 tggttatcct tttgattatc tgcggaacct atgttctgtt tattcaatat ggatctgttc 1481821 ctgaaaagaa atcaaatgac agcgagcctc aggtgtcgaa tgaggaagcg caaagcggca 1481881 aacgaataca tatgccgact tcagggttat tgtccttcat gggcaagcac gccgatgaag 1481941 taacgaaaaa gcttggggaa cctgaacgta ttgacccttc ggcttatgat tacgattggt 1482001 gggtatacaa tcaaggtaag gatcaatata tccaaatcgg ggtattaaac aataaagtgg 1482061 tcacattatt cgcgtcgggt aatgatatta acgccaagcc tttcaaaatt ggagaatcaa 1482121 ctggcgaagt attcaagacc acccaggtgg caccatttgt gaatgtagag tataaaggaa 1482181 attcctatcg gtttgaattt tctgaagaag atatcaatac aagaccgact gtaaaggtag 1482241 gaaagatgta tgtccagctg tatatggaca aatttgaggg gaagctatcc agcatcaggg 1482301 cgtttgatgc gcagaccttt gtaaagcaaa gaccttatga ggtagtgtac cgcggggaat 1482361 taattaaacc gaaagccgtt tcagatgaga aatggaaaaa gatccaaaca acgagcgaaa 1482421 agcaaatcct tgatttgacg aatgtcatac gcgttaaaca tggacttgcg aagcttgagt 1482481 gggatcagcc aacggcggaa gtggcatttg ggcatagtga ggatatgaag gaaaataatt 1482541 atttctccca tgtctctaaa aaatacggct cgctgaaaga ccgcttagaa gaagggcatg 1482601 ttgattttca gcaagcggga gaaaatatcg catacaatta tgtggacggt ccggctgctg 1482661 tagaaggctg gctgaatagc gaaggccatc gaaaagcgct tctgaattca gattatacgc 1482721 atcttggtgt cggagtagac cggaaatatt acacccaaaa ctttattaag cgatggtaat 1482781 gaaagccgcg gacgaatggt tcccggcttt ttctatttcc atacaagctg gtctgaatga 1482841 atgtgctgat agcttacaga taaggccgtt tcccatccct tcagtcaggc tttttcacca 1482901 gtgtataggg atatcgctaa aaattcattt gggaatgaat ataggcgaac acaatgcccg 1482961 acaaaacgat acattgtagt aggtaacgat tttcggaggg ggtgaggatt gtggcgaatc 1483021 aacatgccaa tcattcaatc aatgacttta aacaattcgt caaaaagcat cccaagctga 1483081 taaaagaagt gcgcaaagaa caaagaagct ggcaggacgt atatgaaaat tgggtcctct 1483141 tcggggagag cgacccgatt tgggatccat atcgggaacc ggaagaagct tctgaagctg 1483201 tgcctgaaac accgcaaaaa aatgattttg tctcgaaaat ggtgacagcg gtgaaaaaga 1483261 tggatgtcaa tcaaatgaac gaacaaatca ataaaatgag ccagtcgatc tcatcgttgc 1483321 aaagccttct taatacattt tccggaagcg gacagaagca ttctcagcca ggctctggac 1483381 agcatccttt ttcttttcga aaggattaaa aaaggggagc tcatatgcgc aaagaggttc 1483441 aggaatatat tttagcaaac gaagaacgga aacgattcat cagagaacag ccgatatggt 1483501 accgcaggct ttcaagaaaa ccggatgatc tgtcctcctt tcagcttgaa atgatgaatt 1483561 tttatgaaaa aaccattccg catcgggtga atcagtttac gaacgggatt caaatggcgc 1483621 aaatgatgat gcaaatgttt caagcgatgc ggacaaaaga ttaaaaggcc ccgaagaagg 1483681 gtcttttttc atgcggtcat aaggttttgt tggcggctgc ggttaagcat tttccaattg 1483741 gctggtttca tggtaaacta acaactggag gtgcatgtta tgtatgcgac gatggaatcc 1483801 gtgcggcttc aaagtgaagc tcagcagctt gccgagatga ttctgcagtc ggagacggct 1483861 gagaactacc gcaattgtta caagcgtctc caggaagatg aagaggcagg tcggattatt 1483921 cgttctttta tcaaaataaa agagcagtat gaggatgtac agcgttttgg caaatatcat 1483981 cctgactata gagaaatatc ccggaaaatg agggagatca aacgtgagct ggacctgaac 1484041 gataaggtgg ctgacttcaa gagagctgaa aatgagctcc agtccattct tgatgaggtc 1484101 agcgttgaga ttgggacagc tgtttcggag catgtgaaag ttccgactgg gaacccttat 1484161 tttgacggtt tgtcttcatg cggaggcggc tgcggttcag gcggaagctg cggatgtaaa 1484221 gtgtcctgac gagactggcc gtctcgtctt ttacatataa gagaaaacag gcaggtgatt 1484281 gtattggaga ataggcgcca gggcatggtt gtgtatctgc actccctaaa gcagagcaaa 1484341 atgctgagga agttcgggaa tgtgcactat gtatcaaaac gattaaaata tgtcgtactg 1484401 tactgtgata tggaccaaat tgaaaaaaca atggacaaga ttgcgtctta ctcatttgtg 1484461 aaaaaagtgg agccttctta taaaccgttt ttaaaattgg aattcgagtc aaagcttgat 1484521 aaggcaaaag aatacgatta taaaatcggc atatagctat aaaaaaatcc ccgcaggcat 1484581 ctgcggggtc cttctattcc ttaatatgtt aaggagaagg caaagggaga ggagaaaccg 1484641 gaggaagaac ttatggggaa acgtaagtct tctccgcggt tggcaacaac atcctctaga 1484701 tgctgttgct tatagtatgg acaaggatca tgctgcctat acacctgttt atcaagatta 1484761 gcgttcattg tttggaagaa tgctttatgt taagatagga ttgatttttt tctatgtaca 1484821 tagcggcgtc cggccgaata aagaaacaaa atagctttta gaaaaagtgg tgtggaacat 1484881 gagagtaatt tctggatcaa aaaaaggccg ttcactaaag gctgtagccg gaacatcaac 1484941 aagaccgaca accgacaaag tgaaggaatc cattttcaat atgatcggcc cttattttga 1485001 cgggggcagg ggacttgact tattcgcagg gagcggaggt cttggaatcg aagcgctttc 1485061 acgcgggttt gagcattgta tattcgttga ccgtgatttt aaagcgattc aaacggtaaa 1485121 atctaatttg aaaacgctgg agcttacaaa acatgcacag gtataccgca atgatgcgga 1485181 acgtgctttg cacgctgctg ctaaaagaga aaccggcttt cgcggaattt ttctcgatcc 1485241 gccgtataag gaacaaaagc tgaaagcact tttaactttg attgacgaat atcaaatgct 1485301 ggaagaagac ggctttatcg tcgctgagca tgacagagag gtcgagcttc ccgaaaccgt 1485361 aggagatctt gtgatgacaa gaaaagaaac ctatgggtta acaggtgtag cgatttataa 1485421 aaagaggggg tagtgaggtg gcgagtatag ctgtctgtcc cggcagtttt gatcctgtga 1485481 cctacgggca tctggacatc atcaaacgcg gggcgcatat ttttgaacaa gtgtatgtat 1485541 gtgtgctgaa taattcttca aaaaagcctt tgttcagtgt ggaagaacgg tgtgagcttc 1485601 tgagagaagt cacaaaagac attccgaaca taacagttga aacatcgcaa ggcctgttaa 1485661 ttgattatgc aaaaagaaaa aatgcgaaag cgattttaag aggcttgaga gctgtatctg 1485721 attttgaata cgagatgcag gggacatcag taaaccgggt gcttgatgaa tctattgaga 1485781 cgttttttat gatgacaaac aatcaatatt cgtttctaag ttcaagcatc gtaaaagaag 1485841 tggcaagata caacggctcg gtatcagagt ttgtaccgcc ggaagtagag ttggcgcttc 1485901 agcaaaaatt cagacaagga tgagggtttt gactcatcct ttttttgttc cgtttgtcag 1485961 tctgtaagaa aaaatgataa tgtacgtaaa cagcgcgcat agtgtgacag caggtccgat 1486021 ctgcacaagc agattccagc cgtttataaa ggcagttgac atgtcactgc tgttaagaga 1486081 tttaaataca tactgatacg gatcatgcca tgctgtgtaa agaggtttcc ataaaagcat 1486141 gacgaagaca gcggcataaa cgccctgcag caaacgtgcg ataaagaatg gtttaaatct 1486201 aatgtcggtt tccgataaaa tacctgccac ctgagcttgt acggaaaagc cgctaaaccc 1486261 aagaataaag ctgacgataa tggctttttg cagaagagaa acatctgtct cgctgacaag 1486321 cttgctgcct aatgtaattt caaacatccc tgataaaagc ggaatgtcca attgagtcgg 1486381 aagctgaaac aaagtcagtg ctccttttgt gaaaacagac aaaacatcag tcagctggac 1486441 cactgacaac agccgattga agacagaaaa taaaataata aagccgccta ccataagaag 1486501 cgtttgaaca gaagacgtca cggcgtcgcc taaaatttta cctaagggcc gtttttctgc 1486561 aagtctggcg gtatgaagag cgtgtaaagc atctttgact gaagggaaag gtatcgtttt 1486621 ctttcttctg agatgctgct cttccttgcg gccataggag cgcattgtta aaccgacggc 1486681 aagattcccc aaatagtgtg cagaagctaa taaaatgcct agtgatgcgt tttgaaagaa 1486741 accgacggca acagcgccga aaataaagag cgggtttgaa gaattggtaa acgacgcgag 1486801 ccgttctgcc tctactcttg aaatctgatt ttcctgccgc agacgggcag tgagttttgc 1486861 gcccgctggg tttcctgatg ccattcccat agcaagaacg aagccgccga cacccggcac 1486921 gcgaaagatc ggccgcataa aaggctcaag caaaacaccg acaaaccgca caatgccaaa 1486981 gccgattaag agttcggaca gaataaaaaa tggcagcaat gacggaaaca caacctccca 1487041 ccacatagac agcccggttt tagaggcttc gaatgaggcc tgtggatgtg agatgacagt 1487101 cgctgttaaa aaaagaaaaa acgaggcaat caaaagtgta ttaatcttcg acaagttcat 1487161 tcttacctcc ccgatgctaa aaatgcccaa tgacatgtat atcatgataa aataatgtat 1487221 gatgtaaaac ggccaagcag tacctgtcct cttgattctt tgtactaata tacgagcata 1487281 ggggttcagt ttagaccata gaattcggta tacagggaat tcaggcagga ggttaacgct 1487341 ttggccaaac ctaaaatcgg gttagcgtta ggatcgggag gggccagagg gcttgctcat 1487401 ctcggtgtgc tttccagttt acataagcac caaattgaag tggatatgat tgcaggaagc 1487461 agcatgggcg ctttggtggg cagtttttac gccgccggac atgacgtggc aacgatgaaa 1487521 aaagtagcca aagcctttaa acgaaggctt tatgctgatt atacggtgcc gaaactcggt 1487581 tttttaaaag gtgaccgcgt cagacagctt gtgcatgctt atacattcgg aaaaccgatt 1487641 gaagagctcc aaatcccgct gggcattgtt gcgtgtgatc tacagacggg agaaaagatt 1487701 gtgttccgaa aaggatcagt gtcagatgca gtgagggcca gcatcagcat cccgggtatc 1487761 tttattccgc agcggctgga cggacgcctt cttgtagacg gcgcggtcgt cgatcgaatt 1487821 ccggtttctg ttgtgaaaga catgggagct gatattatca tcgcttcgga tgtttccagg 1487881 gttcgaaaaa ctgaaacagc agtgcatatt tttgatgtga ttatgcaaag tatggatata 1487941 ctgcaaaatg aattagtgcg gcatcaaaca attgccgcag atatcatgat tcgcccttcc 1488001 cttgaaacat acagctcaag ctcgtttgcc aatattgaag aaatgatatc ggcaggcgaa 1488061 gaggcgacaa accgaatgat cagcaagata agaaaagaaa tagagaattg ggagggctca 1488121 taatttgcta cgtaaaaaac attttagctg gatgctcgtc atcctcatac tgatcgccgt 1488181 tttatcattt ataaaacttc catactatat tacaaaaccg ggagaagcga cagagcttgc 1488241 ttcattgata aaagtggagg gaggctaccc ggaaaaagga agtctgtcct taatgactgt 1488301 taaagtggga ccggctaatc catttacata tgtgtgggca aagatgcacc cttattatga 1488361 aattgttcct gatgagagca ttaaggagga aggcgaatca gataaggagt atatgaaaag 1488421 acagctccaa atgatgaaaa gctcgcaaga aaatgcggtt atagccgcct atcaaaaggc 1488481 aggaaaaaaa gtcagctatt cctttaacgg catatacgca agctcagttg tagaaaacat 1488541 gccggcaaaa gggaaaatag aagtcggtga taaaatcatc agcgcagacg gcaaaaacta 1488601 tcagtctgct gaaaagctga ttgattatat cagcagcaaa aaagcgggag ataaagtcac 1488661 gttaaagatc gaaagagaag aaaaagaaaa gcgtgtcacc cttacgttaa aacaatttcc 1488721 tgatgagccg gatcgggcag gaatcggagt ttcgctttat acagacagaa acgtgaaggt 1488781 agagcctgat attgattttg aaatcgaaaa tattggcggc ccgtcagcag ggttaatgat 1488841 gtcccttgaa atctataatc agctgacaaa accagacgaa acaaaaggct acgatattgc 1488901 gggaacaggt acgattgatg ttgacggaaa agtaggcccg atcggcggca ttgatcaaaa 1488961 agtcgtcgcc gcagacaaag ccggaaaaga cattttcttc gcgccaaatc aaaacggcgc 1489021 cagcaattcc gattataaga acgcagtaaa aacagcaaaa gatattgatt caaatatgaa 1489081 gattgtgcct gttgatacca tgcaggatgc gattgattat ttgaataagc tgaaagcgaa 1489141 aagcacctga ttctcaggtg ctttttctat acatttaaaa agtgttgttc atcttcgtca 1489201 tatcgaatcg gtgcatgtcc gtattcctgt aggtcaaact cagttctcag cggctcttct 1489261 atcggcaggc tgtaaatcct gcttgctttt acgtccagat cgagagctgg atgggagaaa 1489321 gaggacagtt tgctgacaag cggaacagac agtgcttttt tcttttcgga taaataagcc 1489381 tgtccttttt tcgtcatgcc gagaagcctg atatacggcg ccttatcgtt gtcaagcagc 1489441 ttttgcatat cctgtttttt tgttctggtt aaaatgtgtg tattcatccg ctggagcctt 1489501 gtccacgtat agcgttttgt tttcagcagt tccataaatt cctgatagga gctggatttt 1489561 ctgatcgaac gaataattct gtgctctaaa ccttcctcca cctcgtatac ttgctgtaat 1489621 tcccgtgccg ttacagttga aaggctgtat tttaagtaag aaaagtagct ttcaggtgta 1489681 tgccacaatc cgaaagattt gcggtaagct gctaattcac gtgcagatgc agcagggaga 1489741 aaacgaaggc aggcttcgag attctggcca atcatcgctt ttctaatgct tgtggcactt 1489801 gctatatggt tttcgccttc agggagatcg gcatcatgat agtccgaaga gattcgtgcc 1489861 gtagtataag gtttcatagg atatcccccg gttagaatcg aggtcacata ctggtatccc 1489921 aaaatgttat ttggttttga caagtcaagt gcactttcag tatgcaaaat ggagctgaag 1489981 gcgatagccg ccgctgctgg gtaactggcc ccctttttaa gttcttcttt aattcggtca 1490041 ttcaatatat gtttatgctc atcaataagc tgtgctgttt ctaaaaaagg cttgatatcc 1490101 ccattttcac tcccgaaaaa cagcgcctca cattcaagtt cgttcaggat ggaaacactg 1490161 ccgcgtgcaa aaatgtctgc tttttgcacg gcataaagat aaggcagctc aatgacaaga 1490221 tcaactccgc tttgcagcgc catttttgtt cgggcccatt ttgatacaac agcgggttcc 1490281 ccgcgctgta aaaaatgtcc gctcatgacc gcgacagccg tgtcacatcc ggtttgcagc 1490341 tttgctgttt gggcatgata aaggtgaccg ttatgaaagg gattatattc aaccaccaat 1490401 ccgacagctt tcatattttt tccgcctttc ttgctatgtt taaaaacgta tggtacattt 1490461 gcaaatgaaa actcttacgc cttatttttg ttttaagtgt atgcatagca tattccgctg 1490521 tcaacgatac ttcaatggca gcattatgct gtaaagaaaa aatattgaca aaaacaatct 1490581 taaaagctat aatcatgttt gttgctttcc tgaggtgata caaatgaaat ggacgattta 1490641 tcagctgcat caaatgccaa aacaaagttt tgagtttgat gaaacagttg agttaaatga 1490701 gctgacaaag ctgaattctg acattcgccg catttctccc gttcgggtga agggcagagc 1490761 ggatatcaaa tccaaacagg tttcgtttga ttttacaatt tcaggcgaaa tgcttttgcc 1490821 atgctcaaga acactcgttg atgttccgta tccatttgaa atttcaacaa aagaactgtt 1490881 tatatttcat cacacggatg atatagaaga tgatgacgtt cacattgttg aggacgatac 1490941 tatcgacata actccgatcg tgaaagaaga aattctttta gaaatcccta tgcaaatctt 1491001 ttgtgaatct gaacaagaaa aaggagctgc tcctcaagaa ggaaaggatt ggcaagtcat 1491061 ttcggaagaa gacaagaaga atcaagttga tccgagactt gcagcccttg aaaagctctt 1491121 aaaacaagat gatgaatctt aactctttaa ggaggtggga ataatggctg taccttttag 1491181 aagaacttct aaaatgaaga aaagattgcg ccgtacacat ttcaaactta atgtacctgg 1491241 tatgacagaa tgtccgtcat gcggagagat gaagttgtct caccgtgtat gcaaagcatg 1491301 cggatcatac aacggcaaag acataaatgt aaaaagtaac taatgagaaa agcgcagggt 1491361 gaaagccctg cgctttttct ttttctcttc ctgtcagctt gcggaaaatt tgtgagtgca 1491421 aatagtctat ctaatctatt accggcatat gtatgagata aataagctga catggaggga 1491481 gattgaattt gaccattaca agacaagatg cttggactca ggatgaggat ttgctgctgg 1491541 cagaagtggt gcttcgtcat attcgagagg gaggaacaca gctttcagcc tttgaggagg 1491601 ttggaagggc gctgaccaga accgcggcag cctgtggttt caggtggaac tcgtatgtga 1491661 gaaaacaata ccagtcaggt atagagcttg caaaaaagca aaggaaagaa ctgagaaagc 1491721 aaatcggcgt tcattcggtc aatatgccga attccatgaa gcagactgcc tcggcatcgt 1491781 cagaaggaaa acgagatttg tccattcagg atgtcattca atttctcgaa caattcaaag 1491841 aaacaccgtc tgcacaagaa tttcagcttg aaagggaaaa attgaaggag caaatccaat 1491901 cgctgcaaaa agagcttgag gatttgcgga gtgaaaatca gacattgcgg aatcagctag 1491961 agatgacaga agaggattac aaggcactga tcgatatcat ggatcgggcc agaaaaatgg 1492021 ttgtttcgaa ggaagacgga agaatgaaaa aagcggctca agaaacgtaa agaaacgcct 1492081 gaaatgaacc ggccctatag taagaatagg ccggttgttt tgatttctat gcagactctc 1492141 ccggtgtcat ttcgcgatcc atatcaggat gccagatgag cgggttttcc cctttgtccc 1492201 gcgccatatc atacttaaca gttttaaagt tcattttgtt ccaaaattcc gctgatttca 1492261 ttctcggatt tgtccggatc ggcattttga atgattttgc aaattcaacc aaggctctcc 1492321 cgtatcccct gttctggtag cccggaagaa cctcaagctt ccacagctcc aaataatcct 1492381 ggcggttgtc aaaataggga ttcgatttgc cgttaacttg atacagactc attcgtgcta 1492441 caagtttatc gccaaaataa atcccgtaaa aaggcgaggt gctgtcattt tcaataatat 1492501 tatcctgaag ttcttcaagc attgaaagct cctgaatgcc gtattctttg aatttcttga 1492561 attcttccag cgttttatag ttgataagca gacgttctac ctttgtcaaa caaatctccc 1492621 cctttgttgt ttctacatat attgtaaacg ctttatttaa aaaatccaaa tatttaaact 1492681 ttaattttaa gcacatggga tctttgagaa gtaatttctt cttacttctg ctatgataat 1492741 acgtaaatgc taaattgggt gtgacatcat gaaaattgga attatcggcg gaggctccgt 1492801 tggtctttta tgcgcctatt atttgtcact ttatcacgac gtgactgttg tgacgaggcg 1492861 gcaagaacag gctgcggcca ttcagtctga aggaatccgg ctttataaag gcggggagga 1492921 attcagggct gattgcagtg cggacacgag tatcaattcg gactttgacc tgcttgtcgt 1492981 gacagtgaag cagcatcagc ttcaatctgt tttttcgtcg cttgaacgaa tcgggaagac 1493041 gaatatatta tttttgcaaa acggcatggg gcatatccac gacctaaaag actggcacgt 1493101 tggccattcc atttatgttg gaatcgttga gcacggagct gtaagaaaat cggatacagc 1493161 tgttgatcat acaggcctag gtgcgataaa atggagcgcg ttcgacgatg ctgaaccaga 1493221 ccggctgaac atcttgtttc agcataacca ttcggatttt ccgatttatt atgagacgga 1493281 ttggtaccgt ctgctgacgg gcaagctgat tgtaaatgcg tgtattaatc ctttaactgc 1493341 gttattgcaa gtgaaaaatg gagaactgct gacaacgcca gcttatctgg cttttatgaa 1493401 gctggtattt caggaggcat gccgcatttt aaaacttgaa aatgaagaaa aggcttggga 1493461 gcgggttcag gccgtttgtg ggcaaacgaa agagaatcgt tcatcaatgc tggttgacgt 1493521 cattggaggc cggcagacgg aagctgacgc cattatcgga tacttattga aggaagcaag 1493581 tcttcaaggt cttgatgccg tccacctaga gtttttatat ggcagcatca aagcattgga 1493641 gcgaaataca aacaaagtct tttgagcttt ttcggtaaca tgctatactc atttcggatc 1493701 actaactatt tattggagaa aggaagttct agaagatgca gctaactgaa ctttccatca 1493761 aaaatcagaa tgtgtttgta cagcactata tagatggcaa agaagaaatg tcttcttttt 1493821 ttgattacag tattcatcat aaggacatgt ggcgcgaaag actggaagac ttatcttccc 1493881 ggtttttcgc aagagaggaa ttggcggcgt acttaacctc ttaccataat aaattcggtt 1493941 caagtgcgat gcagtctgct attgagaagc tgaaggaccc gtcaagtgcc gctgtagtcg 1494001 gcggacagca ggcaggactt ttaacaggac cgctttacac catacataaa atcatttcaa 1494061 tcattgtttt agcaaagcaa caagaaaagg aactgcaagt gcctgtcata ccaatcttct 1494121 gggtggctgg agaagaccac gatttggatg agattaattt tgttcacaca tctgaagaga 1494181 atgggcctgt gaaaaaaaag ctgcctcagt cttattggaa gaaatcatca gcagcgagta 1494241 catcgcttga tcaggaaaag tgtgccgcgt ggatagatga tgtttttgcc gcttttgaag 1494301 aaacagacca tacgaataca cttctcgaca atgtgaaacg atgtttaagg gaatctgtta 1494361 cgtttactga cttctttgaa ctgctgatcg cggatttgtt ccaagaagag ggcttagttt 1494421 tattaaattc tggggatccg gggattaaaa agctggaaac ggccatgttc caaaagattc 1494481 ttcgagaaaa tgatgaactc gcccgggctg tatcagatca gcaggccttc atgcgtcaag 1494541 caggctacaa accgattatc gagtccggaa aagagcaggc gaatctgttt tatgaatacg 1494601 aagatgagcg ttttttaatt gaaaaagata acggccgatt tgtcatcaaa gagcttgatc 1494661 taggatggac gagggatgaa cttcatacac atatggaaga acatccagag cgtttcagca 1494721 acaatgttgt aacgagaccg ttaatgcagg aatttctcat tccgacttta gcatttattg 1494781 cagggcctgg ggaaatcaat tattggggcg agctcaaaca ggcatttgcg gtgatgggct 1494841 tcaaaatgcc tcctgtcatg ccaaggctga acattacgat acttgagcgg catattgaga 1494901 aaaaactggc tgaacggaat atctcattac aagacgcgat tgagcgcgga acggagaatc 1494961 aaagagagac atacttcgag cgccagattc cggaagagtt tacggcggtg atggatcagg 1495021 cgaaaagcca aattgaagcg attcacaaaa cggtccggca ggaggcgtta aaggttgatc 1495081 aaagcttgga acctttactt ctgaaaaatg ccgcttttat tcaggatcag cttcaattct 1495141 tagagcgcac ggtgatgaag cgaattgaag aaaaagaagg ctacgtcttg aaggattatg 1495201 aaagaattca aaatagcatt aagccgcttc ttgcgccgca agaacggatt tggaatatca 1495261 tgtattattt gaacaggtac ggtccaaaat tcttcacgac attcaagaat ctgccatttt 1495321 cttttcaaaa tcaacatcaa gttgtcaaac tttgaaataa agttttaaag aaccctgact 1495381 agttcagggt ttttttttat gggtaaacag tgtaaaatga agttgtggag cgaagtggtg 1495441 aatagtggtg agttaaggag agaaagtggg gcaagagatc atgtttatgg gtgaatatca 1495501 gcataccatc gatgcgaaag gccgcatgat cgtacccgct aaattcagag aaggcctagg 1495561 tgagcaattt gtgctgacta gaggacttga ccaatgtctc ttcggctacc ctatgcacga 1495621 atggaaacaa attgaagaaa aactaaaagc tcttcctctc acaaagaaag atgcccgcgc 1495681 gtttacccgt ttcttctttt caggggcgac tgaatgcgaa ctggataagc aaggcagggt 1495741 aaatatcgca tcatctctat tgaattacgc caaactggaa aaagaatgtg ttgttatcgg 1495801 ggtttctaat cgaattgaat tgtggagtaa agtaatttgg gaacaataca cagaagagca 1495861 agaagattca tttgctgaaa ttgctgaaaa catgattggg tttgatatat aatgattctt 1495921 cgtgtataac actctaaaaa caatttcaat tcatcctgat aaaaggtggg accaacacaa 1495981 tatgtttcaa cacaagacag tacttcttcg tgaaaccgta gacggactta atattaaacc 1496041 agacggtaca tatgtagact gcacactcgg cggagctggg catagtacat acttattgca 1496101 gcagttatcc gagaaggggc gtttaatcgc ttttgaccaa gatgatacgg cattacagca 1496161 tgctaaagaa gtgttgtccg attataaagg acagctcatt ctgattaaaa gcaatttcag 1496221 gtatttaaaa gaatatttga atgaacaagg cgttacagaa gtagacggca ttttatttga 1496281 tttaggggtg tcctctccgc agctggatac accggagcgc ggattcagtt accatcatga 1496341 cgcaccgttg gacatgagga tggaccagtc ggctacgctt tcggcgaaag aagtcgttaa 1496401 tgagtggcgc tatgaggatc tcgtccgtat tttctttaaa tacggagaag agaagttcag 1496461 taaacagatc gccagaaaaa ttgaggaggc aagaatgaag tctcctattc aaactacggg 1496521 ccaactggtc gatctaataa aagacgcgat tcccgctcca gcgagaagga gcgggggaca 1496581 tcccgctaaa cgcgtgtttc aggcaatcag aattgccgta aacgatgaac ttagggtgtt 1496641 tgaagaagct ttggagcagg caattgaggt tctgaagcca gggggcaggg tatcggtcat 1496701 taccttccac tcgctagaag acagaatttg caaaaccact tttaaagaaa agtcgtcgct 1496761 tccggaactt cctccgggac ttcctgttat accggaagag tttgaaccgg agctgaagct 1496821 catcacacga aaaccgatta cggcatctca agaagagctt gaagagaaca accgggctcg 1496881 ttctgccaag cttcggattg ctgaaaaaag aaaataacga aacgcgaacg caaaattaaa 1496941 aggaggtcat cagcctatga gcaatttagc ttaccaacca gagaaacagc agcggcatgc 1497001 gatcagtcct gagaaaaaag tgattgtcaa gaaaagggct tccattactc tcggagaaaa 1497061 agtgcttctt gtcctctttg ctgcggcggt gctcagcgta tcgcttttga tcgtatcgaa 1497121 ggcgtatgcg gcatatcaaa ccaatattga ggtgcaaaag cttgaggagc aaatttcatc 1497181 cgaaaataag caaattggtg acctcgaaaa aagcgttgct gatttaagca aaccgcagcg 1497241 cattatggac attgcgaaaa agaacggctt gaatttaaaa gataaaaaag tgaaaaacat 1497301 acaggaatga ttcaaatgcc aaaaaagaat aaatttatga atagaggagc agcgattcta 1497361 agtatttgtt tcgctctctt tttctttgtc atcctgggga gaatggcata tattcaaata 1497421 accggaaaag cgaacggcga agtgcttgcg acaaaagcga cagagcagca tgaaaagaaa 1497481 cggaccatcg aagcgagccg cggctcgatt ttagaccgaa aaggaaaagt cattgcagag 1497541 gacacagcga cgtataaact gattgcgatt ctcgataaaa aaatgaccac tgatgtcaag 1497601 catcctcagc atgttgtaaa caaagaaaaa acggcggaag cattgtctaa agtgataaac 1497661 ttggacaagg ccgacatcct tgatatctta aataaagatg caaaacaagt cgagtttggc 1497721 tcagctggcc gggatattac gtattcacaa aagcaaaaaa tcgaaaaaat gaaactcccg 1497781 ggcatttcat ttttacggga tacaaaacgc tactatccaa acggagtatt tgcatctaat 1497841 ctaatcggct atgccgaggt tgatgaagaa acaaatgaaa tttccggcgc gatgggatta 1497901 gaaaaagtgc tggataagta tttgaaggag cgggacggat atgtgacata tgaaagcgac 1497961 aaatccggct gggagctccc gaacagcaaa aataaaatta cagcgccaaa aaatggtgac 1498021 aatgtatatt taaccattga ccagaaaatt caaacctttt tggaagacag catgacaaaa 1498081 gtggcgcaaa agtataatcc gaaaaaaatc atggccgcag tcgttgatcc gaaaacgggc 1498141 aaagtccttg ccatgggaca gcgcccaagc tttgatccga acaagcgcga tgtgacaaac 1498201 tactataatg atttgatttc atatgcgtat gaacccgggt ccacgatgaa gatctttaca 1498261 ctcgctgctg cgatgcagga aaacgtgttt aatgcgaacg aaaaatataa atcagggaca 1498321 tttgaagttg gcggagcacc tgttaaggat cacaataacg gtgtaggctg gggtccgaca 1498381 acatatcatg acggcgtcct aaggtcgtcg aatgtcgctt ttgcgaaact ggcgaaagaa 1498441 aagctgggat atgaccgcct caatcaatat ttgcacaaat tcaattttta ccagaaaaca 1498501 ggtattgatt tgccaggaga agtctccagc aaaatcaact ttaaatatga atttgataag 1498561 gcgtcaactg catatggcca agcgtctgcg gtcacaccaa ttcagcagat tcaggccgca 1498621 acggcaattg caaatgacgg taaaatgatg aaaccttatg tcattgacca tatcgttgac 1498681 cctgataaag ataaaactat ttatcaaaat aagccggaat cagccggaac tccaatttct 1498741 gcaagtactg cgaaaaaggt gcgggatata ttaggagaag tcgttacatc gaagatcgga 1498801 acagggcaag cttataaaat cgaaggtttt gatgttgccg ggaaaacagg tactgcgcaa 1498861 atagccggta aaggcggata tttagacggc acagataact atatcttttc gtttatgggt 1498921 atggcgccaa aagatgatcc tgagctttta atttatgttg ctgtacagca gccgcaacta 1498981 aaagcaggac aaagcagttc agatccagta tcagaaatct tcaatccaac aatgaaaaat 1499041 agcctgcact acctaaacat cgaaccaact gaaaaatctg actcagataa ggaagaaaca 1499101 aaagcgcaga caatgcctga tttaacagat caaacggtag ctgctgctca aaagaaagca 1499161 aaagaggaga atctcacacc aattgtcatc ggcagtgatg tcgctgtaaa agaacagtat 1499221 ccgaaagcgg atgaggaagt tctcaccaat caaaaggtct tcctgaaaac gggcggcaaa 1499281 atcaaaatgc ctgatatgac aggctggtcg agaagagagg ttctgcagta cggcgagctc 1499341 gcgggaattc atattgaagt aagcggacaa ggctacgctg tcagccaaag tgttaagaaa 1499401 gacaaagaaa tcaaagacaa aaccgtaatc aaggttaagt ttaaaaatcc tgattaaaaa 1499461 gaaagccgtc gttatgcagg ctttcttttt ttatgccttc agaggagcat cgttctacct 1499521 gtccaaattc aggcataaaa tgaaacaagc ctaaataagg agtgaacggt ctcttgcgcg 1499581 tctcgaatgt aacggttaga aaacgtttat tatttgtttt gctttttggc gtgatcgtgt 1499641 ttctgatcat tgatacaagg ctggggtatg ttcagtttgt gatgggcgaa aaactgactt 1499701 cgctagcgaa agattcctgg agccggaact tgccgtttga gccggagaga ggcgagattc 1499761 tggatcggaa tggtgtgaag ctcgcaacaa ataaaagtgc gccgaccgta ttcgtcgtgc 1499821 cgcgccaagt tcagaatccg atgaaaacga gcaagcagct tgcggcggtg ctcaatatgt 1499881 cagaagaaaa agtatataaa catgtgacaa aaaaagcgtc aatcgaaaag atcactcctg 1499941 aagggagaaa aatttcaaat gagaaggcga aagaaatcaa agcgcttgat ttaaaaggtg 1500001 tgtatgttgc ggaggacagt atccgtcatt acccgttcgg cagcttttta tctcatgtgc 1500061 ttggatttgc aggaattgac aaccaagggc tccttggact tgaagcctat tacgacgatg 1500121 atttaaaagg ggaaaaaggt tctgttaagt tttatacaga tgccaagggg aagaagatgc 1500181 ctgatgaagc ggatgactat acgccgccta aggatgggct tgatatgaag ctgacagttg 1500241 attcaaaggt tcagacgata atggaaagag agcttgataa cgctgaggcc aaatatcatc 1500301 cggacggcat gattgccgta gccatgaatc cgaaaaacgg agaaattttg gggatgtcta 1500361 gcaggcctga cttcgaccct gctgattacc aatctgttga tccgtccgtc tacaatcgaa 1500421 atctgccagt atggagcacg tatgaaccgg gatctacctt taaaattatt acacttgcag 1500481 cagcccttga agagcaaaaa gtaaatttga aacgggatca attttatgat aaagggcatg 1500541 ctgaagtgga cggagcgaga ctgcggtgct ggaaaagagg cgggcacggg ctgcagacgt 1500601 atctggaagt tgtgcagaac tcctgcaacc cggggtttgt tgaattaggc gagcgcttag 1500661 gaaaggaaaa gcttttcaaa tatatcaaag actttggttt tggacaaaaa acggggattg 1500721 atctccaagg cgagggaaca ggcatcttat tcccgcttga gagagtgggc ccggtggagc 1500781 aagcaactac ggctttcgga cagggagtat ccgtcacgcc gattcagcag gttgcagcag 1500841 tatccgccgc tgtaaacgga ggaacgctct atacacctta tattgcaaag gaatggatcg 1500901 atcctgttac gaagaaaacg gtcaaaaaac aatcaccaat cgcaaagaaa caagtcattt 1500961 ctgaggaaac atccaaacaa atccgctatg ctctagaaag cgtcgtcgca gaaggaaccg 1501021 gccgcaatgc atttgtagaa ggatatcgtg tcggaggaaa aacgggaact gcacaaaagg 1501081 ttaaagatgg aaaatatctt gaaaacaacc atattgtatc atttatcggt ttcgcgccag 1501141 cagatgatcc gagtctagtc gtctacgttg cggtggataa cccgaaaggc acgattcagt 1501201 ttggcggaac ggtggcagcg cctattgtcg gaaatattat gagagacagt ctgccggaac 1501261 ttggtgtgaa gccccggaaa aatcaaatcg agaaaaaata ccaatggaac gacacaaaaa 1501321 caatagaagt tccgaatgtt gtagggatgt ctgtctcaga tcttgagtca ctattggtga 1501381 atctcaatgt ggatgcttcc gggaaaggga gcaaaatcgt taaacaatcg ccagctgccg 1501441 gaacgaaagt aaaagaaggc tcaaagatac gcgtgtattt gactgaagaa gatgaaaagg 1501501 aggcagccga ttgattcggg ctgcctattc ttttattgca gaaaaaatgc tgatatcttt 1501561 caagattagc tggatgtatc cttttattta cgctaaaata tgaactgtat gcttaaaatc 1501621 attaccacat catttgatgt gacttcaatg ataaaaagaa cgaattagaa tgttgagagg 1501681 tttgatacga tgaaacttac aaagctgctt acatacttaa caaccgaacc ttctgtaaac 1501741 gactcacaag accctgaaat aacttcaatt gagatggact ccagggaagt aaagaaaggg 1501801 agtctttttg tatgtgtaaa agggtatacg gtggatggcc acgattttgc gcaaaaagca 1501861 gtagaaaacg gtgcagcggc tattgtggca gaaagagagg tcgatgtgaa tgttcctgtt 1501921 attattgtcc ggcagtcact tcgcgcgctc agcgttttgt ctgatgcgtt ttacggacag 1501981 ccgacgaaga agcttcagct gattgggata acagggacaa acggcaaaac atcaacgacc 1502041 cacatggtcg atgagattct gaaaaaagcg ggaaaacgca caggcttgat cggtacaatg 1502101 tacatgaaaa tcggagacga aacacttcct gttaaaaaca cgactccgga aagcgtcacg 1502161 ctgcagaaaa cgtttaagaa aatgaatgac aagcacgttg acactgcaat catggaggtt 1502221 tcttcccacg ctttgtcttt aggacgcgtc catggctgtg attatgatat tgccgtgttt 1502281 acgaatttaa cacaggacca tctggactat cataaaacga tggatgagta ccggcatgca 1502341 aaaagcttgc tcttttccca acttggcggg gctttcaacc atgaacatcc aaagcgtgcc 1502401 gtcctgaatg ctgacgatga ggcgagcgct tattttgaaa aggtaacagc tgcgcatatc 1502461 tctacatacg gaattaaaaa cgatgctgat gtgatggcga agaacatcag tatcactgca 1502521 cagggcacaa gctttgatct cgtgacaaac aaaggcacga agcacatcac gatgtctctc 1502581 gtcggacaat ttaatgtgta taacgtgctg gccgctgttg cgacatgtat tgcagcaggc 1502641 ataccgtttg aaatcatcac tgaggctgtt gaagaattgc atggtgtaag aggccgtttt 1502701 gaattggtca atcagcagca ggagtttcct gtcattgtag actacgcgca cacaccggac 1502761 agccttgaaa atgtgctgga gacatgcaga gacatgacgg aaggaaagct atttgtcgtt 1502821 gtcggctgcg gaggagacag agataagacg aagcgcccga aaatggctaa aattgctgtg 1502881 gagctggctg acgagccgat tttcacgtca gataacccga gaagcgaaga tcctcgcgcg 1502941 attttaagag atatggaagc cggagtagag aacgcatact atcacagtat tgcaaaccgc 1503001 gagcaggcga tctttttcgc aattgccaat gccaaaaaag gcgacgttgt cctcattgcc 1503061 ggaaaaggac atgaaaccta tcagcagatc ggaaatgaaa ctttcgattt tgatgatgct 1503121 gaagtagcgg cgagagccat tgttgaactc aataagaata agacgaattc ataggaaaga 1503181 gatgttactg aataatggag cttgaaaaga tttttcatat ggaaaaaaat catgaatatg 1503241 ataactacgt atgtcgtttg aaagaaacag gaggagaaaa ggacaatgct tgagcaagtc 1503301 attctgttta caattttaat ggggttttta attagtgttc tgctctctcc gattcttatt 1503361 ccgtttttaa gaagattaaa attcggccag agtattagag aagaaggacc gaaatcacat 1503421 cagaaaaaat cagggacacc gacaatgggc ggggtcatga tcatactttc tatcatagtg 1503481 acaacaattg ttatgacaca gaagttttca gaaataagcc ccgaaatggt gctgcttctg 1503541 tttgttacgc taggctacgg tttgcttggc tttttagatg attacatcaa ggttgtcatg 1503601 aagcgcaatc ttggattgac atcaaagcaa aagctgatcg gacaaattat tattgcggtt 1503661 gtattttacg ccgtgtatca ttactacaat tttgcgacgg atattcgcat tcctggaact 1503721 gacttatcat ttgatcttgg ctgggcttac tttatccttg tgctctttat gctagtcggc 1503781 ggatcaaacg cagttaacct gactgacggc cttgacgggt tattatccgg tactgcggcg 1503841 attgcctttg gcgcctttgc cattctggca tggaatcagt ctcaatatga cgtagcgatt 1503901 ttctcagttg ccgttgtcgg tgcagttctg ggcttccttg tatttaatgc tcatccggcc 1503961 aaagttttta tgggagatac gggatcgctt gcattgggag gagccatcgt taccattgcc 1504021 attttaacga aattagagat cctgctggtt atcatcggcg gtgtattcgt tatcgagaca 1504081 ttatccgtta ttttgcaggt catcagcttt aaaacgacag gtaaacgaat ctttaaaatg 1504141 agtccgcttc atcaccatta tgagcttgtc ggctggtctg aatggagagt agtcgtgacg 1504201 ttttgggctg cgggactttt gcttgccgtt ttaggaattt acatcgaggt gtggttataa 1504261 gtggaaaatg atcaattttt acagaaacag cattttttaa tccttgggct tgcgaaaagc 1504321 ggatatgcgg cggcctccat tcttcatgaa aaaggcattt atgttgcagt caatgatcaa 1504381 aagccttttg aagaaaatga accggcacaa aagctttctg aaaaaggaat cgaagttgtt 1504441 tgcggagagc atccagtttc tctgttcgat cagcatcaaa tcacgattct gatcaaaaac 1504501 ccgggaattc cttatgaaaa tatcatggtt caggaagcag agaaacgagg tattccggtt 1504561 tggacggaaa ttgagctcgc ttactacctg accagcgcca agtttatcgg gattaccgga 1504621 tcgaacggta aaacgaccac gacaacgcta atttacgaaa tgctcaaggc tgactcgcaa 1504681 aaagcactga ttgccggaaa catcggcaca gtcgcaagtg aggttgccta tcatgctgat 1504741 ggagatgaat ggatcgttac cgaactgtct tcgtttcagc tgatgggaac acacgctttc 1504801 agaccggaaa tcagcctgat tttaaatgta tttgacgccc atctggatta tcaccatacg 1504861 cgcgaaaact atgaaaaagc gaaacagaaa gtgtaccttc atcagactgc ttcagataaa 1504921 gctattgtca accaggatga tgaaaccgtc gtgcgtcttg ctgaagccgg aaaagccgaa 1504981 atcgtcccat tttcagtcag caaaacgctt gaacagggcg catatgtaaa agacagtatg 1505041 attatgttta acggcgaagc cattcttcct ctggaagagg ttgtactgcc cggtgctcat 1505101 aacctggaga acattttagc agctattgca gttgtgaaaa cggcaggagc atccaatgag 1505161 gcggttaaaa aggtgctgac aagctttact ggtgtgaagc accgcctcca atatgtcaca 1505221 actgtgaatg gccgcaaatt ttataacgac agtaaagcaa caaacattct ggcgacaagc 1505281 aaggcgcttt cagcttttga taagccggtc attctgcttg cgggcggact ggatcgcgga 1505341 aatggttttg atgacttgaa accttatatg aagcatgtca aagcagtgct tacatttggc 1505401 cagacggcgc caaaactcga gaaactcggc aatgaactgg gaatacaaca tgtcaaacgt 1505461 gtcgataatg ttgaacaagc agtatctgcg gcgtttgcgc tctcaaatga aggagatgtc 1505521 atcctgctgt cacccgcgtg tgcgagctgg gatcaattca aaacatttga agaacgcggt 1505581 gacatgttta tagatgccgt gcatatgctt aagtaagggc ttgtcttgaa gtaaatcggc 1505641 agccctaatg actttaagct tggggtgtcg attgctttga ctactaaaaa aacatcgcct 1505701 gatttgttat tggtcatcat tacgttatta ttattaacaa tcggattaat tatggtgtac 1505761 agtgcgagtg cggtatgggc ggattataaa tttgacgact cattcttttt cgcgaaacgg 1505821 cagcttttgt ttgcgggaat cggcgtcatt gctatgtttt ttatcatgaa tgttgattat 1505881 tggacttgga ggacatggtc caaattgctg atggttatct gctttttcct tctggtgctt 1505941 gttttgatac cgggcgtcgg aatggtgcgg aacggttcaa gaagctggat cggagtcgga 1506001 gcattcagca tacagccttc agagtttatg aagcttgcga tgattgcatt ccttgctaaa 1506061 tttctctctg aaaaacaaaa aaacatcaca tcgttcagac gggggttcgt ccctgcactt 1506121 ggcatcgtgt tttcagcatt tttgattatc atgtgccagc ctgacctcgg aacggggaca 1506181 gttatggtcg gaacttgtat tgtcatgatt tttgtagccg gcgcacggat cgcccatttc 1506241 gtctttctcg ggctgatcgg cctcagcgga tttgtcgggc tcgtactatc ggctccatat 1506301 cggataaagc ggattacctc atacttaaat ccatgggaag acccgctcgg aagcggattt 1506361 cagatcattc aatcgcttta tgcagtgggg cccggcgggt tgttcggaat ggggctcgga 1506421 caaagcagac agaagttctt ttatctgcct gagccgcaaa cagactttat tttcgccatc 1506481 ttgtcagagg agctgggctt tatcggggga acacttattt tgctcctctt cagcgtcctg 1506541 ctgtggagag gaatcagaat tgcgcttggt gcgcctgatc tgtacggaag ctttgtcgca 1506601 gtcggcatta tttcaatgat tgccattcaa gtcatgataa atatcggcgt agtcacgggc 1506661 ctgattcctg taacaggcat cacgctcccg tttctgagct acggaggctc ttcattgact 1506721 ctaatgctga tggcagttgg tgtgctgctg aatgtaagcc gctactcgag gtattaacga 1506781 atgtatttcc aagcctcctg tctaacatga agcttggaaa caattgatgc gataaccctg 1506841 tccaacaaaa cagggttatc gttatgttat agagaaactt agactggggg aaaaaagaaa 1506901 tgcgaattgc aataagcgga ggcggtacag ggggacatat ttatcctgct cttgctttta 1506961 ttaaagaagt gcaaagacgt catcctaatg tggaattttt atatatcgga acagaaaacg 1507021 ggctggagaa aaaaattgtt gagcgggaga atataccgtt tcgttcaatt gaaattacag 1507081 gatttaaaag aaaattgtca tttgaaaatg tcaagactgt gatgcgtttt ctgaagggcg 1507141 tcaaaaagag taaatcgtat ttagcggaat ttaagcccga tgccgtaatt ggaacgggcg 1507201 gttatgtatg tgggccggtt gtctatgccg ctgcgaaaat gggaattccg actattgtcc 1507261 acgaacaaaa cagcctgccg ggcatcacga ataagtttct ttcaaaatat gttaataaag 1507321 tagcgatttg ttttgaagaa gcgaaatcac attttcctag cgagaaagtt gtatttacgg 1507381 gaaacccgag agcctctgaa gtcgtctcaa taaagacggg acgatcattg gctgaatttg 1507441 ggctttctga agacaaaaaa acggtcttaa ttttcggcgg aagccgaggc gctgcaccga 1507501 ttaaccgcgc tgtcattgac atgcaggatg tgctgaaaac aagagactat caagtgctgt 1507561 atatcaccgg tgaagttcac tatgaaaaag taatgaatga gctgaaaagc aagggtgccg 1507621 ctgataatat ggtcacaaag ccgtttcttc atcaaatgcc tgagtattta aaggccattg 1507681 atgtcattgt ggccagagcc ggtgcgacaa cgattgccga aattactgct ctcggaatcc 1507741 caagtgttct gatcccaagt ccatatgtga cagcgaatca ccaggaggtc aatgcgaggt 1507801 ctcttggcca gcatgatgcg gcgattgtac tgaaagaaac agagctcagc ggggagaagc 1507861 tgattgaagc gctagaccgg attgtactga atgagcaaac gttaaaggaa atgagcgaac 1507921 gaacaaagtc actcggtgtt cctgacgcgg ctgcccgttt atacagcgta ctcgaggaat 1507981 taaaaaaata gtagaaaagc aaatggaatg cggaggttta cgatggagaa agtgatacag 1508041 gaattaaaag aacgagaagt cggcaaggtt cttgcaaatg aaccgctcgc gaatcataca 1508101 acgatgaaaa tcggcggacc tgcggatgta ttggtcattc caagcagtgt ggatgctgtt 1508161 aaagacatca tggacgtgat taaaaaatat gatgtgaagt ggacagtcat cggccgcgga 1508221 tcaaatcttc ttgttttaga tgaaggaatt agaggcgtag tgatcaagct gggggcgggt 1508281 cttgaccatt tggagcttga aggggaacaa gtaacagtcg gaggcggtta ttcggtggtc 1508341 cgccttgcta catcattgag caaaaaaggc ctgtccggtt tggaatttgc tgccggcatt 1508401 ccaggatcag tcggcggagc ggtttatatg aatgccggcg ctcacggttc tgatatgagc 1508461 gagatcctcg tcaaagcgca tattttattt gaagacggaa cgattgagtg gctgacaaat 1508521 gagcagatgg atttcagcta caggacatct gtactgcaaa agaaacgccc gggcgtttgc 1508581 cttgaagctg ttttgcagct tgagcagaag gataaggaat caatcgttca gcaaatgcaa 1508641 agcaataaag actatagaaa aaatacacag ccgtattcaa gcccttgtgc gggaagcata 1508701 ttcagaaatc cgcttccgaa tcatgccggg aaccttgtag aaaaagcagg cttgaaagga 1508761 tatcaaatcg gcggtgcaaa gatatcggag atgcacggaa acttcatcgt caatgcgggg 1508821 ggagcatcag caaaagatgt gcttgatctc attgaccatg tgaaaaagac aatccgtgaa 1508881 aaatacgaga ttgatatgca cacagaggtt gaaatcatcg gcggaaatcg ctgattcaag 1508941 ttctgactga agctgttcat atgatatact gtaagcaaac gacaaacggc atcatagtat 1509001 gccgtttgtt ttggaataga cagactttta acagctgttt catttgaatg aggtgaacag 1509061 gcaatgaacc cgggtcaaga ccgagaaaaa atcgttaaca ttgaagagcg gatccctaaa 1509121 attaaagagc agaggaaaca aaaggcaaac cgccgtctca tttcatttat tatgctcttt 1509181 tttattatgg tgctgatcat tgtgtacctg caaacaccaa tcagtaaagt atcaacaatc 1509241 tctgttacag ggaatgaaaa tgtatcaaaa aaggaaatta tcgacctttc cgatattaac 1509301 agcggagata ctgagttttg gagtttggac aagcaaaaaa cagaaaagaa gattcagcaa 1509361 aataaattag tgaaaaaagc ggagatcagc aaatcgcttc ctaataaaat caacattgca 1509421 atcgaagaat ataaagcgat tgcttattta gaaaaagacg atgtgtacta tgaagtgctt 1509481 gaaaacggct cagttctgcc aaacgaagta acgccggatg atgccggacc gattttagtg 1509541 aattggacaa acgcgaagaa gcggtctcaa atggccaagc agctcgatgc gttgtcaaat 1509601 tcgttaaaac agtcgatttc agaaatttat tatacgcctg taaaaatgga tgaaaaccgt 1509661 attaagttgt acatgaacga cggttatgtt gttacggcat ctattaaaac gtttgcagac 1509721 cgaatgaaga cgtatccttc tatcatctca cagctaagca gcaataaaaa aggaatcatt 1509781 catttagaag ttgccaccta ttttgaagag tttgggaaaa acgataaagc tgctaaaaag 1509841 gaagatgaaa attgaggggc aaatcagcag tccttctttc cttgattatg cttatcgcag 1509901 gttttttgat ttcattttct tttcaaatga caaaagaaaa caacaaaagc gcggctgaga 1509961 cggaagagtg gaaaaaagaa tatgcgctga gagatgaact gctgaaacaa gagaaagaaa 1510021 ataagaagtt tgaaaaagaa ttatatcaaa agcaaaacaa agtccgccag gcggaaaata 1510081 agctgaagaa agagaagtcg gaatactata atgtcctcga agatacagaa aaatacagga 1510141 tgtatattgg ggaagtcggt gtgcagggag aaggcgttga ggtgacattg gaagatgcgt 1510201 catacatacc ggaaggggag aatgtgaata gttacatcgt tcacgaaagc catatcttcc 1510261 aagtagtaaa cgaactgtat atctcaggag cggcagctgt cgccgttaat ggacagcgtt 1510321 tgacgcatga ttcgtatatc aaatgcaatg gtcctgtggt aacggtagac ggggtgcagc 1510381 atcccgctcc gtttacggta tccgctattg gagatccaga tgtcctgctg ccctcgttaa 1510441 atatcgctgg aggcctaatt gatcagctgt caatggatca tatttctgtg tcggcagaaa 1510501 aagagaaaaa cgtacaaatg aaaccgattc tgaaaacgaa ggaatgactg aaaaagcggg 1510561 tgaaatagat tgaaaataaa gcgttccttc ataagcatca gtgttcttat ggtcatcttc 1510621 ggcctgatga tatctgttca gtttaattcg ttaaagcacc ccaaagtccg ggatacaaga 1510681 gatatgtggg atattaggga agagctgaca tcagagcaga agaagcagga aaagctgctg 1510741 gctgaaataa acaaatatga caaattgctg aatagctatt cgcaaacgaa agaaatgaca 1510801 aaagaaaccg cgctaaataa taccttgcaa tccttaaaaa aaacagccgg catgaccgat 1510861 ataacaggta gcggaattgt cattacgatt tccccgcttt tttctgaaag cttaacagga 1510921 gagccgatcg aaaatccgcc tccggatttg ctgaaaaagc tgataaatga actcaactcc 1510981 tacggtgcag agcatatctc gattaatgag cgaagagttg tgaatcatac agtcatcaga 1511041 gatataaacg gcactacaaa aatagacgga tacgcccttg acgattatcc tttaacagta 1511101 aaagtgcttg ccaaagatcc ggacatgtta cacagcagag tgaaggggtc aggccttgag 1511161 gatctttttg catctgaaaa tttagcatta aaagccggta aatctgaaag caaactaaca 1511221 ttaaaagcat atgacagacc actggacgta caacagctga aactgcttaa agactgaaaa 1511281 ggaggagaat tgtcatgtgg ctgcccgtgt tgggactggt gctcggaata gcgattggac 1511341 taatgacaaa cttaacgata ccgagtgaat actcaaacta tttatcgctt gcggtgcttg 1511401 ccgcacttga tacattaatc ggcggaatca gggcgcattt acaaggtaca tatgatgaaa 1511461 tggtatttgt ttccggtttc ttttttaata ttatattggc aataagttta gcttttctgg 1511521 gagtccatct tggtgtagac ttgtatttag caggtatatt cgcatttgga gtcagattat 1511581 ttcagaatat agccgttatc agaagaaatc tactaacaaa gtggactctt tctaaaaaaa 1511641 ataaaaaaaa tgtgatataa aagaggatat acataggata taacgaatat tttcaataaa 1511701 cataaaatgt gaaaagcaca taaaaatatt ctgttgttat tttttgttac acacttgtaa 1511761 agccacattc attgtattgt tgttccgcaa ataatagaat agaaatgatc gaaatgtgag 1511821 gaggtgccat agaatgaaca acaatgaact ttacgtcagt cttgacatcg gtacgtccaa 1511881 tacaaaagtg atcgtcggag aaatgacaga tgattccctt aatattatcg gtgtgggaaa 1511941 tgtaccgtct gaagggttga aaaaaggctc aatcgttgat atagatgaga ccgttcattc 1512001 tataagaaaa gcgtttgacc aagctgaaag aatggtaggt tttccgctta gaaaagctat 1512061 tgtcggcgtt aatggaaatt atatcaatat tcaagataca aacggtgttg tagcagtttc 1512121 cagtgaaaat aaagaaattc aggttgaaga tgtacgccgt gtcatggagg cggcacaggt 1512181 tgtttccgta ccgcatgaac agctgattgt tgacgtcatt cctaaacagt ttatcgtaga 1512241 tggaagagat gaaatcaccg acccgaaaaa aatgctgggt gtgcgtttag aagtagaggg 1512301 caccttgatc accggttcaa aaacaatctt acataactta ctccgctgcg ttgaaagagc 1512361 tggtattgaa ataactgata tttgccttca gccgctggca gccggttctg ctgcattatc 1512421 aaaggacgag aaaaaccttg gtgtggctct cattgatata gggggagggt caacaaccat 1512481 tgccgtattc cagaacggac atctcacttc tacccgtgtc attcctctcg gaggcgaaaa 1512541 tatcaccaaa gatatctcca tcggattgag aacgtcaaca gaagaagcag aacgcgtgaa 1512601 aaagcaactt ggacatgcct actatgacga agcctcggaa gatgaaatat ttgaggtaac 1512661 cgttataggc accaatcaaa aacaaacatt tacacagcaa gaagcagcga atatcattga 1512721 agcgagagta gaggaaattc ttgaaattgt ttcagaagag cttcgcagta tgggaattac 1512781 cgatctgccg ggaggcttcg tgctgacagg aggacaagca gctatgccgg gtgtcatgtc 1512841 tttggcacag gatgtgctgc aaaacaatgt cagagtggca agcccgaatt atatcggtgt 1512901 aagagatcct caatatatga cgggagtggg cctgatccaa ttcgcctgcc ggaatgcaag 1512961 aatccaaggc agaaaaatag gctttaagat gcctgaagaa gcgatacagg aaatcgcagt 1513021 ctcatcatct gaggaacaag agcagcatca tcaccaaaat gaggtgcagc agcggccaaa 1513081 aggaaaacaa aaaacacaag ccgaacataa taaacagagc aaaatgaaaa aactattaag 1513141 catgttttgg gaatagatag atagtcattc ggcagattag gaggatttag catgttggag 1513201 ttcgaaacaa acatagacgg cttagcatca attaaagtaa tcggagtagg aggcggcggt 1513261 aacaacgccg ttaaccgaat gattgaaaat gaagtgcaag gagtagagta tatcgcggta 1513321 aacacggacg ctcaagctct taacctgtca aaagcagaag tgaaaatgca aatcggcgca 1513381 aagctgacta gaggattggg agcaggtgcg aatccggaag tcgggaaaaa agccgctgaa 1513441 gaaagcaaag agcagattga agaagcactt aaaggtgctg acatggtatt cgtgacagct 1513501 ggtatgggcg gcggaacagg aacaggtgcc gcaccggtta tcgcacaaat cgcgaaagac 1513561 ttaggcgcat taacagtcgg cgttgtgaca agaccgttta ccttcgaagg acgcaaaaga 1513621 cagcttcagg ctgcaggcgg aatctcggca atgaaagaag cggtggatac actgatcgtg 1513681 atcccgaacg accgtatcct tgaaattgtt gataaaaaca caccgatgct tgaagcattc 1513741 cgcgaagcgg ataacgtact tcgccaaggg gttcaaggta tttctgactt gattgctaca 1513801 cctggtctta tcaaccttga ctttgctgat gtgaaaacaa tcatgtcaaa caaaggatct 1513861 gctttgatgg gtatcggtat tgctactggg gaaaatcgcg cggcagaggc agcaaaaaaa 1513921 gcaatttcca gcccgcttct tgaagcggcc attgacggtg cgcaaggcgt cctcatgaac 1513981 atcactggag gaacaaacct cagcctatat gaggttcagg aagcagcaga cattgtcgct 1514041 tcggcgtctg atcaagacgt aaacatgatt ttcggttctg ttattaatga aaatctaaaa 1514101 gatgagattg tggtgacagt gattgcaacc ggctttatcg aacaagagaa ggacgtgacg 1514161 aagcctcagc gtccaagctt aaatcaaagc atcaaaacac acaatcaaag tgttccgaag 1514221 cgtgagccaa aacgtgagga acctcagcag cagaacacag taagccgtca tacttcacag 1514281 ccggctgatg atacgcttga catcccgaca ttcttaagaa accgtaataa acgcggctaa 1514341 tgtaaaggac aaaatcgttt tcgattttgt ccttttttgt ttttctcttc acactttcct 1514401 tcttataaag tctttttccc tattgcttcc ttcgcttagt aacaaaacag ataattagac 1514461 ccatttattt ttgtgacatt tttatcattt tcatatatat ggaaattgaa tgacatgaaa 1514521 cgacaatatc tgtaattcag attgtctaca gttaatatac agcgatgttc tgacaaacca 1514581 ttcattatta aaaggaggga cgacactttt tttaaaaagc atgttgaaaa agggggatga 1514641 aaatgaggaa aaaaacgaaa aacagactca tcagctctgt tttaagtaca gttgtcatca 1514701 gttcactgct gtttccggga gcagccgggg caagcagtaa agtcacctca ccttctgtta 1514761 aaaaggagct tcaatctgcg gaatccattc aaaacaagat ttcgagttca ttaaagaaaa 1514821 gctttaaaaa gaaagaaaaa acgacttttc tgattaaatt taaagatctg gctaacccag 1514881 aaaaagcggc aaaagcggct gttaaaaaag cgaaatcgaa gaagctgtct gccgctaaga 1514941 cggaatatca aaagcgttct gctgttgtgt catctttaaa agtcacagcc gatgaatccc 1515001 agcaagatgt cctaaaatac ttgaacaccc agaaagataa aggaaatgca gaccaaattc 1515061 attcttatta tgtggtgaac gggattgctg ttcatgcctc aaaagaggtt atggaaaaag 1515121 tggtgcagtt tcccgaagtg gaaaaggtgc ttcctaatga gaaacggcag ctttttaagt 1515181 catcctcccc atttaatatg aaaaaagcac agaaagctat taaagcaact gacggtgtgg 1515241 aatggaatgt agaccaaatc gatgccccaa aagcttgggc acttggatat gatggaactg 1515301 gcacggttgt tgcgtccatt gataccgggg tggaatggaa tcatccggca ttaaaagaga 1515361 aatatcgcgg atataatccg gaaaatccta atgagcctga aaatgaaatg aactggtatg 1515421 atgccgtagc aggcgaggca agcccttatg atgatttggc tcatggaacc cacgtgacag 1515481 gcacgatggt gggctctgaa cctgatggaa caaatcaaat cggtgtagca cctggcgcaa 1515541 aatggattgc tgttaaagcg ttctctgaag atggcggcac tgatgctgac attttggaag 1515601 ctggtgaatg ggttttagca ccaaaggacg cggaaggaaa tccccacccg gaaatggctc 1515661 ctgatgttgt caataactca tggggagggg gctctggact tgatgaatgg tacagagaca 1515721 tggtcaatgc ctggcgtgcg gccgatattt tccctgagtt ttcagcgggg aatacggatc 1515781 tctttattcc cggcgggcct ggttctatcg caaatccggc aaactatcca gaatcgtttg 1515841 caactggagc gactgatatc aataaaaagc tcgctgactt ttctcttcaa gggccatctc 1515901 catatgatga aataaagccg gaaatatctg caccgggcgt taatattcgt tcatccgttc 1515961 ccggtcagac atatgaggat ggttgggacg gcacatcaat ggcagggccg catgtatccg 1516021 ctgttgctgc actgctgaaa caggcgaatg cctcactttc tgttgatgag atggaggata 1516081 tattaaccag cacggctgaa ccgctcacgg attcaacatt tcctgattca ccgaataacg 1516141 gatatggcca tggtctggtg aatgcttttg atgctgtatc cgctgttaca gatggattag 1516201 ggaaagcgga aggacaagtt tctgtagagg gggatgacca agagcctcct gtctatcagc 1516261 atgagaaagt aactgaagct tatgaaggtg gcagcctacc actgactttg acagctgaag 1516321 acaatgtgag tgtgacatct gtaaagctgt cctacaagct tgatcaaggt gaatggacag 1516381 aaataacggc taaacgaatc agcggtgatc atctaaaagg aacgtatcag gcagagatcc 1516441 cagatataaa aggaactaaa ctaagctata agtggatgat tcacgatttt ggcggtcatg 1516501 tcgtttcgtc tgacgtatac gatgtaacag tgaaaccaag catcacggcg ggatataagc 1516561 aggactttga aactgcaccc ggcggctggg ttgcgagcgg aacaaataat aactgggaat 1516621 ggggagttcc gtcaactggc ccaaatacag cagcatccgg agaaaaagta tatggaacga 1516681 atttgacagg aaattatgcc aactcagcaa acatgaacct tgttatgcct cctattaaag 1516741 cacctgattc aggaagtctg ttccttcaat ttaaaagctg gcacaattta gaggatgatt 1516801 ttgattacgg ctacgttttt gttcttccgg aaggtgaaaa gaattgggag caggctggtg 1516861 tctataacgg aaagacatca agctggacgg acgaagaaat tgatttatcg gcttataaag 1516921 gccaaaacat tcaagtgatg tttaaccttc aatctgatga aagcattgca aaagagggct 1516981 ggtatattga tgatgtagtg ctttctgaca aatcagccgg aaaaacagtc aaaaagaata 1517041 agctgggcgt cgaaaagccg tctggaaagc aaaagaaaaa gccagtaaat ccgaaaaagg 1517101 ctaagccatc tgcaaacaca gcggtaaaac atcagaacaa ggctatacag cctcaagttt 1517161 tgccgctcaa ggcacaagtc agtgtagtgg aaacaggaaa atcaacatat tcagatcaat 1517221 ccacagggca gtacacgctg aagcacaaag cgggagacta tacgcttatg gcagaagcat 1517281 atggttatca gtcgaaaaca caaaaagtat ctttaaagac ggatcagacg acacaagcta 1517341 attttacgtt agaagagatg aagaagggca cattaaaagg cacggtcatc aataaaacga 1517401 caggagagcc ggtaacaggc gcttccgttt atgttgtaga ggatgctgcg gtggaaccgg 1517461 ctatgacaaa cgacaaaggt gaatatatgc tggaggccta tgaaggcgct tatacgatta 1517521 aagtcgctgc accgggttat tacagtgatg aattttccgt tgagttaaaa ggtgatgtta 1517581 caaaagaaac tgcattgaag cctttcgtcg gttatccggg tgaaattgca tatgatgacg 1517641 gaacagcgga gaatgccaat tcctattttg ctgccggtaa cggatgggcg gtaaaaatga 1517701 cgctcgctga cggcaaggac aaaggcatgc ttacaggagg gctgttcaga ttctgggata 1517761 cagagttccc tgatccgggc ggcacagagt ttaaggttga ggtatacgat gccacaggaa 1517821 aagacggagc accgggcaag aaaattgcag ggccatttaa cgcggaagct cttcgcaatg 1517881 gcgagtggac taaggtagat ctcagttcaa aagggattat ggtcgataaa gatttttatc 1517941 tcgtatatat ccagtcgaaa cctgatccgt attcacctgg attggcaatg gatgaaaccg 1518001 gccagaattc cggccgcaac tggcagtata tagatggaaa gtggcagcca ggtgacaaag 1518061 cggatggcaa ctatatgatt cgcgcattag ttgattatga agctgctgta cctgagatta 1518121 cttcaccgac agacaaatca tacacaaata aggatagcgt cactgtaaaa ggaaacgctt 1518181 ctcctggcac aacggtacac atttataatg gagagaaaga agcaggagaa acgaaagctg 1518241 ctgcggatgg cacgttccat gcaggcatca tactcaacaa gggtgaaaat gagctgacgg 1518301 caactgcatc aactgacaac ggaacaacag atgcctccag cccaatcacg gtcacgcttg 1518361 atcaagaaaa gcctgaatta acactggaca atccaaagga tggcgggaaa acaaataaag 1518421 aaacgctgac tgtcaaaggg gctgtatccg atgacaatct gaaagacgtc aaggtgaatg 1518481 gcaaaaaagc aacagtagct gatggttcat actcagcccg tattcttttg gaaaatggaa 1518541 gaaatgaaat caaggtaatt gctacagact tggcaggcaa caaaacgacg aaaaagacag 1518601 tcattgatgt gaactttgac aagcctgtca tttccggctt aattccggga gaggataaaa 1518661 acttaaaagc cggtgaatct gtgaaaatcg ctttctcaag cgctgaggat ttagatgcaa 1518721 cgtttaccat tcgtatgccg ctgaccaatg caagagcgag tgtgcaaaat gccaccgaac 1518781 tcccgttaag agaaatctct ccggggagat atgaaggcta ttggactgcc acttcttcta 1518841 ttaaagcaaa aggagcaaaa gtagaagtga tcgtccgaga tgattatgga aatgaaacaa 1518901 gaaaaactgc gaatggaaaa cttaatatga acacagaaaa ttaagtggaa aaaaagctgc 1518961 cgtcattggc agcttttttt atatcctctc attatacttc ctcgacaaat taagcagatt 1519021 tccctgaaaa attgtatttt cctctcaaca ttaattgaca gactttccca cagagcttgc 1519081 tttatactta tgaagcaaga aggggaacag cgtgaggcaa gaaagaaagg agtcagatgt 1519141 gaaaatctat ttagatgtca tttggctgtt aaacttttgt tttgatgcac ttttgctttt 1519201 gctcacggca tttattttaa aacggcatgt aaaaaaaaga agactggtag gcggagcgtt 1519261 catcggttcc agtattgtcc ttttgatgtt tactcctttt tcgccgattg ttgaacatcc 1519321 ggctgggaag ctagcttttt cagttgtgat tgtggtggtg acatttggct ttaaaagatt 1519381 tcggtttttc tttcaaaatt tgttttcctt ttattttgcc acttttttaa tggggggagg 1519441 aattatcgga gcccattctt tgctgcagtc aaattctatt gttcaaaacg gtgtcatgat 1519501 taccaatcaa acagggtttg gagacccgat cagctggttg tttattgttg gtggctttcc 1519561 agcattatgg tttttttcta aaagaagaat tgaagatatt gaaacaaaaa acattcaata 1519621 tgaggaacga gtcagcgtgc aggcagattt gggcagccaa acacttcatg tcagaggcct 1519681 gattgattcc ggtaaccagc tgtacgatcc tcttacaaaa acaccggtaa tgatcattta 1519741 cattgataaa ctggagccga ttttcggaac agccgaaacg atgatcattc gaaacacaga 1519801 cccattggaa gccatcgaac agctcgatga ttcctttcgc tttttagata aaatgaggtt 1519861 gattccatac aggggagttg gtcagcaaaa tcaattttta ttatgcgtta aaccggatca 1519921 cgtaacgatt atgacaaaag aagaaatgat ttctgcagat aaatgtttaa tcggtatcag 1519981 cacaacaaag ctgtcggcag atggagagtt tgacgcgatt attcatccga aaatgctttc 1520041 gggcaaggct gtcaaacacg tttcataatg ttcgcaaatg tccgttactt atcatactca 1520101 aacggcgtga catttagaag ggagaggaag atgaaaaaac tgaaattacg gttgacgcac 1520161 ctctggtata agctgctgat gaaacttggg ctgaaaagtg atgaagtcta ttacataggc 1520221 gggagtgaag ccctgccgcc tccattatct aaagatgagg agcaggtttt gttaatgaag 1520281 ctcccaaacg gcgatcaggc ggcgcgcgcc attctaattg aacgcaattt gcgtctggtc 1520341 gtatatatcg cccgtaaatt tgaaaatacg ggaattaata tagaggattt aatcagcatc 1520401 ggtaccatcg gtctaatcaa agctgttaat acatttaatc cagaaaagaa aatcaagctt 1520461 gctacctatg cctcccggtg tatagaaaat gaaatcctga tgtatttaag aagaaataac 1520521 aaaatccgtt cagaggtttc ctttgatgaa ccgcttaata ttgattggga cggcaatgag 1520581 cttttgcttt ctgatgtgct cggcactgac gatgacatca tcactaaaga catagaagct 1520641 aacgtcgata aaaagctttt gaaaaaagcg cttgaacagc ttaatgagag agaaaagcaa 1520701 atcatggagc tgcggtttgg gcttgtcggt gaagaagaaa aaacccaaaa ggatgtagcg 1520761 gatatgatgg ggatttctca gtcttatatt tcgcggcttg agaaaagaat tataaaaagg 1520821 ttgagaaaag agttcaacaa aatggtgtaa aaaattttat ggttagaacc ccttgatttt 1520881 acagggattt cctgatttcg acagtttttc ggtctgagtg cagtgcatat ttttcccacc 1520941 caaggagata cttaacgttg tacagcagct cctgtaggga gggaaaaaag tgtcgagaaa 1521001 taaagtcgaa atctgcgggg tggatacctc caaattacca gtactcaaga atgaagagat 1521061 gagaaagctg tttaggcagc tgcaggatga aggcgatgat tcagcaagag aaaagcttgt 1521121 aaacgggaac ttgcgtcttg tcttaagtgt cattcaacga tttaataaca gaggggagta 1521181 tgttgatgac ttatttcaag tcggctgcat cggactaatg aaatccattg ataattttga 1521241 cctaagccac aatgttaagt tttcaacata cgctgtacct atgattatcg gagagatccg 1521301 caggtattta cgtgataata acccgatccg tgtctcaaga tcactccggg acatcgctta 1521361 caaggcgctt caggtaagag agcggttaat cagtgagaca agcaaggagc cgactgcaga 1521421 agacatcgca aaagttcttg aagtaccgca tgaggaaatt gtatttgcgc ttgatgccat 1521481 tcaggatccg gtttctctat ttgaaccgat ctataacgac ggcggagacc cgatctatgt 1521541 gatggaccaa atcagtgatg agcgtaatac agattcacaa tggattgaag agctggcttt 1521601 aaaagagggc atgagaaggc tgaacgatag ggaaaaaatg attttgagaa agcgattctt 1521661 ccaagggaaa acccaaatgg aagtcgccga ggaaatcgga atttctcaag cgcaggtgtc 1521721 cagacttgaa aaagcggcta tcaaacaaat gaataaaaat attcatcaat aatgaaaagc 1521781 ctttaaaacg atgttgtttt aaaggctttt ctattgatta tggatggttt acgttttgga 1521841 aaaagtaagg tatcctagtt cgtacaaagt tttatgaaaa ttaaaacaat tataaaaggc 1521901 aataaagagg aggaccacga tgattttgca gcttgacaat gtctcactaa aacggaatgg 1521961 gaaatggata ctgaaagata ttcattggaa ggtggaagaa aaggaaaatt gggtgcttta 1522021 cggcctaaat ggcgccggga agacagcgct gttaaatatg ctttgctcat attattttcc 1522081 aacatcaggc gagatgcagg tgctcggcca tgaatttggc aaaacagagc ttggggaaaa 1522141 gctcagacgt aaaattggcc tcgtctcagc agctcttcag caaaaattgt atccggcaga 1522201 ttcagctttt gaaattgctt tgagcggagc ttacgcttcg attgggttat atgaaacgcc 1522261 aagtaaggaa accagggaaa aagcgatagg tttgttagag gacttgggag caattgaata 1522321 tgccgatcgc cgctatgaaa ccctttctca aggggaaaaa caaagagcat tgattgctag 1522381 agcactaatg gccgatccgg agctgctgat actggatgaa ccagtcacag gactggattt 1522441 tattgcccgg gaaaagctgt tagatacgat tacatacatt gcaaacaaag aaaatgcacc 1522501 atctatcctt tatgtgactc atcatgctga agaaattttg cctgtctttg ataaagccct 1522561 tttattaaaa cagggagagg tttttggatc cggagaaata aaggaaatgc ttactgatca 1522621 aatactttcc gctttttttg atacgccaat ccatgtatta tggaatcagg atcggccgtt 1522681 tttaacaaga gctgagccga taacgaatgc ctgacaaata tatatagatt catcctaggg 1522741 gtgctttgcg aagctgagag agactttgtc tcaacccttt tgacctgatc tggatcatgc 1522801 cagcggaggg aagcggtgaa aagcggagta catcggactc cgtttgtttt tattaagccg 1522861 tttcatcaca tttgaaacgg cttttttgat tttaaagaat aggagcggat ttacattgga 1522921 tcaacaaata tactctttgc aaaaaaaagt ggaagaacat aaggaggagc ttattcagct 1522981 tgcgaaaacg ctgatttctt atcaaacacc tgctccgcct gcaagaaata cagagggcat 1523041 tcagtcttgg attgcgggat atttaaatga attgggattc tcgatcgaca aatgggatgt 1523101 gtaccctgga gatcccaatg ttgtagggaa gctaaaagga acagattcag cagattatta 1523161 tagcctgatt atcaatggcc atgtagatgt ggcagaggta aaagaggatg aagaatggaa 1523221 gcacgatccg tttcatccca ttgaaaaaaa cggtctctta atcgggcgag gcgcttccga 1523281 tatgaagggc ggaatggctt gtgtgctgtt tgctgtcaaa ttaattcgtg aagcaagcat 1523341 tgaacttcca ggtgatctga ttctgcaatc ggttattggg gaggaagttg gagaggccgg 1523401 cacacttgaa tgctgcaaga ggggctacca cgctgatttt gcaattgtcg cggatacgag 1523461 cgatatgcat attcaaggcc aaggcggtgt cattacaggc tggatcgaaa tcaaaagcag 1523521 tcaaacattt catgatggaa cgagacggaa tatgattcat gcaggcggag gaacattcgg 1523581 agcaagcgca attgaaaaaa tggcaaaaat cattgcgggg ctcggtgaac ttgagcgcca 1523641 ctggtctatt atgaaaagtt atcccggttt taaaccaggc acaaatacga ttaacccggc 1523701 agttatagaa ggcggcagac atgcggcttt tatagcggac gaatgccggc tgtggatcac 1523761 agtccatttt tatccgaatg aaacccatga ccaagtggca gcggaaatag aagattacgt 1523821 caatcggctg agtgacagtg atatttggct tagggaaaac cgccctgtat tcaagtgggg 1523881 aggctcatct atgatagaag acaggggaga aatttttccg gcattggaag ttgaccctgg 1523941 ccacccaggc gtcttagcgc taactgcctc tcatcagaaa gtgaaacggg agtgtccaat 1524001 tattgacgtt tctcaatcag ttacagatgg cggatggctg tatgatgccg gtattccatg 1524061 cgtaatatac ggtcctggag atctgcacaa tgcacactct gtgaacgaga aggtatcgat 1524121 tgagcagcta gtagagtata caaaaattat actcgatttt atcatcagct ggtgcagccg 1524181 gaaaaaagaa caatgacatg aaaatttctt cttgctgaca aggttcagcc tgcccgttca 1524241 tatacttgaa caaaaggacg gaaaaaggac gtgatggaat gatcagcatt tcagaatttc 1524301 aggtaaagga tgtcgtcaat gtctcaaacg gaaaaaagct ggggagtatt ggtgatattg 1524361 atatcaatgt gaccactgga aaaattcagg cgatcatact cggaggaaat gggaaagttc 1524421 tcggattttt tggaaaagaa gaggaattgg tcattccatg gcgaaatata gtaaaaatcg 1524481 gggaagatgt aatcttagtc cgattaagtg aaccacatgc ataaacctgc ttgtctgccg 1524541 cagattggca aatgccggaa gtctcgattc ttccggcaca tttcatttag aaatatgcaa 1524601 atcggcgctc aacgaatgca gtaagatgtg gtaaaataag tgggaaattc cgctttttta 1524661 aatgtttgtc gaaaggttgg atcatcatga atacatatca cccattcagt cttaccacac 1524721 cctcgacact catgatacaa gactgggctc aaacgaatca aaacaacaaa gaggtcattg 1524781 ccggatttac gacaaaaaac ggcggtgtca gccaaaagcc ttttgaatcg ttaaatacag 1524841 gattgcacgt tcatgacaaa gatgcagatg tagttaaaaa tcgtgaatat attgccgata 1524901 tgtttaatac tgatttgcag tcttgggtat tcgctgatca gacacatgat aatcgcgttc 1524961 agaaagtgac gcagagggat aggggaaaag gcgcccgtga gtatcacacg gctctaaaag 1525021 caacggacgg gatctataca aatgaaaaaa atgtattttt agcattatgc tttgctgatt 1525081 gtgtgcctct tttcttttat gatccggtta agtcgcttgt cggagtcgcc catgccgggt 1525141 ggaaaggcac cgtcaaacag attggcagag aaatggtgaa gcaatggact gagaaggaag 1525201 gttcaaatcc ctcagatatt tacgctgtta ttggcccgtc tatcagcgga gcatgctata 1525261 cggtagacga ccgcgtcatg gatgctgtcc gcgcattgcc ggtttcagca gaccttgccg 1525321 ccaatcagac ggcaaaggca caatatcagc ttgatctgaa agagctgaac cgtcttatac 1525381 tgatggacag cggtttggca agtgaacaaa tttctgtcag cggtttatgc acggaaagcg 1525441 agccgtctct tttctattct catcgccgcg atcaggggaa aactggacgg atgatgtcct 1525501 ttatcggaat gaaggaggca taaaagatct tgcgtgttgt tgataattta cgacatataa 1525561 acgaacgaat aaacgaagca tgtaacagat cgggccgcag ctccgatgaa gttacggtta 1525621 ttgcagtcac aaaatatgta tcacctgaaa gagcacagga ggcagtagat gctggcatca 1525681 cctgcctcgg agagaatcgg gatgcggaac tgctccgcaa acaggaattg atgaaaggga 1525741 atccggaatg gcattttatc ggcagtctgc aatcaagaaa agcaaaatct gtcgtcaatt 1525801 cggtttccta tatccattcc ctagaccggc tctcattagc gaaagaaatt gaaaaacggg 1525861 ctgaaggtac tgtacgatgc tttgtgcagg tcaatacctc tcttgagcct tctaaacatg 1525921 gcatgaaaaa agaagaagtc attccattca tacaggagct ttccggtttc gaacatatcc 1525981 ttgttgccgg gctgatgaca atggctccgc tgactgatga tcaagatcag atcagaagct 1526041 gtttcaggtc gctgagagaa ctccgtgacc aggttcagaa gctgaaccag ccgaacgctc 1526101 cgtgtactga actgtcgatg ggcatgtcaa atgattttga aattgcaatt gaagaaggag 1526161 ctacttatat tagaatcggc tcatcgttag tcggaaatga aacagggggt gtacagcaat 1526221 gagtatgaaa aataaactga aaaacttttt ctcaatggaa gatgaagaat acgaatatga 1526281 atatattgag acagagcggg aatctcatga ggagcatgag caaaaagaaa agccggctta 1526341 caacgggaat aaacctgcgg gcaaacagaa tgtagtgagc ttgcaaagtg ttcagaaatc 1526401 ctctaaagtg gtgttgagtg agccgcgcgt ttatgcggag gcgcaggaaa tagccgacca 1526461 tttgaagaac cggcgggcag ttgtcgtcaa tcttcagcgg atacagcatg accaggcgaa 1526521 gcggattgtt gactttttaa gcggaaccgt ttatgccatt ggcggcgata ttcaaagaat 1526581 cggctcagat attttcctct gcacgcctga caacgtagat gtatcaggca caatttctga 1526641 gctcatatct gaagacgaac atcagaggtg gtaaagcgag atgatccttt atcaagtttt 1526701 ttcggtttta agcttattaa tcacaatata ctcatttgcc ctgatcatat atatttttat 1526761 gtcatgggtg ccgagtacga gggaaacagc agtcgggcgt tttttggctt cgatttgtga 1526821 accatatctc gaaccattca gaaaaatcat ccctccgatt gcaatgctgg atatttcacc 1526881 aatcgtagca atacttgtgc ttcggtttgc gacaaccggc ttgtggggac tttatcgcat 1526941 gattgcgttt taatgtgaca gtttgatagg ggcttggcag cagccaagcc tctttacata 1527001 gaagggaaag acgatgagcg atatatatca gcacttcaga aaagacgagc gggcctttat 1527061 tgatcaagcg ctcgaatgga aaagaattgt ccaggagcag taccggatga agctgaccga 1527121 ctttttagat ccccgagagc aggtcatcct ctctgctgtt acgggacagg cagatgtcgg 1527181 gcttgccttt tccggcggct atgacagagc ggagcggaaa cgggcgattc tgtttccaga 1527241 gtacattact ccggaagaat cagattttga actgcaggcg tttaacgtcc gttatgctga 1527301 caagtttgtc tcagtagatc atcgttctct gcttggtgca ttaatgggca taggattaaa 1527361 gcggcaaaaa ttcggtgaca tcgtgttttc tgagacagca gtgcaattga ttgtctcagc 1527421 cgataccgct gattttgtgg ctgcacagct gacccaagca ggcaaagcgg cggtcagcct 1527481 agagaaaatc gacttgtcag accttaacat tccagcagtt gatgtcgaaa taagagatga 1527541 cacggtttct tctttaaggc ttgacgccgt ctgcgcctct atgagcaggc aatcccgcca 1527601 gaaatcacag acgcttgtga aaaacggcct tgtgaaagtg aactggaagg tggttgaaga 1527661 tccttcatac atagtcgcgg aaggggacat gctgtctatc agaggttttg gccggtgcag 1527721 cttaacaaaa atcgaaggaa aaaccaaaaa agacaaatgg agagttacgt ttgaacgaca 1527781 aaaatagtcg gtttttcagt ttttttctcc atctgtgcga aatttgtttt ataatgtgaa 1527841 ctagataacc gtactgaaat gtaaaaatgg aggtggcatc atgccattaa cgccaaatga 1527901 tattcacaac aagacgttta caaaaagttt tcgcggatat gatgaagatg aagtaaatga 1527961 attcctagcc caagtcagaa aagattacga aattgttctc cgcaagaaaa ctgagcttga 1528021 agcgaaagtc aatgagcttg atgaaagaat cggacacttt gccaatattg aggagacatt 1528081 gaataaatca attttagttg ctcaagaagc ggctgaagac gtaaaacgca attctcaaaa 1528141 agaagcaaag ctgatcgttc gggaagcgga gaaaaacgct gatcgcatta tcaacgaatc 1528201 gttatcaaaa tcaagaaaaa ttgcaatgga aattgaagag ctgaaaaaac agtctaaagt 1528261 gttcagaaca cgtttccaaa tgctgattga agctcagctt gatcttctga aaaatgacga 1528321 ttgggatcat ctccttgagt atgaagtcga cgctgtattt gaggaaaagg aataaattct 1528381 ctgattatct tgacattttc ttagcttgtc gaatataata cgttcataaa ttcagatgaa 1528441 aaaacggttg aaagggacag tcatgtttcc ttcaggcctt catagcgacc cggagatggt 1528501 gagagtccgg gatggccgga atcatgtaga tcagcccttt agtttccttg ctgaactcac 1528561 agtaggttag gacgttcatc acgttacgat gctcaagagg aaaaagtgta tgcttgcttt 1528621 ttctaaaagg gtggtaccgc gagataagct ttctcgtccc ttatgggatg agagggcttt 1528681 ttttattttc tgaaaaaatg cagtggagga atgaaaatgg attttaaaga cacgctctta 1528741 atgccgaaaa cagatttccc gatgcgtgga aatttgccaa accgtgagcc tgacattcaa 1528801 aaaaaatggg aggaagaaga tatctaccgt cttgttcagg aacggacgaa agaccgcccg 1528861 aaatttgttt tacatgacgg acctccgtat gcaaacggcg acatccatat gggccatgca 1528921 cttaacaaga ttttgaaaga cttcattgtc cgctataaat caatgagcgg ctacaacgca 1528981 ccgtatgtgc cgggctggga tacacacgga ttgccaattg aaacagctct gacaaaaaac 1529041 aaaaaggtca accgcaaaga aatgtcagta gcggaattcc gcaaactatg cgaagagtac 1529101 gcttggaagc aaatcgaggg acagcgtgag caattcaaac gtcttggtgt ccgcggtgac 1529161 tgggaaaacc catatgtgac attaaaaccg gaatacgaag cgcagcaaat ccgcgtattt 1529221 ggtgaaatgg caaaacgagg ctacatttac aaaggcctta aaccggttaa ctggtcacct 1529281 tcaagtgagt ctgctctggc tgaagccgag atcgaatatc aagataaacg ttcagcatct 1529341 atttacgtcg cttttggtgt aaaagacgga aaaggcgttc ttgaaaacgg cgagcgcatc 1529401 atcatttgga caacaacgcc gtggacaatt ccggcgaacc tcggaatctc agtgcaccct 1529461 gatcttgagt acagcgtgat tgcagtaggt gaagaccgct ttgttgtagc aagtgcctta 1529521 gtcgaaaatg ttgcatcggc atgcggattt gatcagtatg aagtgacaag aacggtcaaa 1529581 gggaaagacc ttgagaacat tatcgctgaa cacccgctat atggcagaga ctctctcgtt 1529641 atgcttggtg aacacgtaac aactgatgcc ggaacaggct gtgttcatac agcgcctgga 1529701 catggggaag atgactttat catcggccaa aaatacggtt tagatgtgct ttgcccggtc 1529761 gatgaaaaag gtgtaatgac aagcgaagct cctggctttg aaggcatgtt ctatgatgat 1529821 gcaaacaaag cgatcacaca gcagcttgat gaaaaaggcg cacttgtgaa gcttgaattc 1529881 attactcatt cttatccgca tgattggaga acaaaaaaac caaccatttt cagagcaaca 1529941 gcgcaatggt ttgcgtctat taaagatttc agatcagacc tgctggatgc cattaaagaa 1530001 accaaatggg ttcctgaatg gggcgagcag cgtttgcaca acatggttcg ggaccgcgga 1530061 gactggtgta tttccagaca gcgtgcgtgg ggtgtgccga ttccggtatt ttacgctgaa 1530121 aacggagaac cggttattac agatgaaacc attgaacatg tttctgaatt gttcagacag 1530181 catggatcaa acatttggtt tgaaaaagaa gcaaaggatc ttcttccgga aggctttacg 1530241 catcctggca gcccgaacgg cacatttaca aaagaacagg atatcatgga tgtttggttt 1530301 gattcaggct cttcacatca agcagtgctt gaagaacgtg atgacctcgt tcgcccggct 1530361 gatctatacc tagagggatc tgaccaatat cgcggctggt ttaactcttc tctttctaca 1530421 gcagtagccg taacagggaa agcgccgtat aaaggtgtgc tcagccatgg gttcgcactg 1530481 gatggagaag gacgtaagat gagtaaatca atcggtaacg ttgttgttcc ggctaaagtc 1530541 atgaaacagc ttggtgccga catcttaaga ttatgggtat cttcagtgga ttatcaggcg 1530601 gacgttcgcg tgtctgacgc cattctgaag caggttgcgg aagtatatcg taaaatccgc 1530661 aacacgttcc gtttccttca cggcaacctt ttcgattttg atccaaaaac aaatgcggtg 1530721 gctgtcgaag atcttcgcga agtggatcag tatatgctga ttaagctgaa caagctgatt 1530781 gataaagtga aaaaagcgta tgatgagtac gaatttgcgg ttgtgtatca cagcattcat 1530841 aatttctgca caatcgaatt gagctcattc taccttgatt ttgcaaaaga tattgtctac 1530901 atcgagcatg cggatcatcc ggatagacgc agcatgcaga cagtattcta cgaaacgctt 1530961 cttgcattag tgaagctttc agcgcctatc cttccacata cggcagacga attgtggtct 1531021 catttaacat ttgttgaaga gcagagcgtt cagttgaccg atatgccgga aacaatcacg 1531081 gttccaaaca gtgaagcgac tgaagaaaaa tttgaccgct ttatggctct tcgtgatgac 1531141 gtgttaaaag cattagaaac tgcgcgaaat gaaaaaatta tcggtaaatc tttggaagca 1531201 aacctgaaat tgtatccaaa caaagaaaac aaggagctct tggcttccat aaaagaaaac 1531261 ctttctcagc tgtttattgt gtctgaactg acaatcagcg aagaaaatga agcgccgaac 1531321 gatgcgcaaa gctttgcgac gggtaaaatc gctgtcgaga aagcggaagg cgaaatgtgt 1531381 gagagatctc gtgtgatttc aaaagatgta ggggcaaatc cgaaatatcc tacactttca 1531441 ttacgcaacg ctgaaatcgt tgaaaaatac tatcaaaaat aatgcaaaag agcccggcgt 1531501 aaaagccggg ctttttttgt gccaagagtg acatccttta gaacgaaagg aaaaatctta 1531561 tgggctttag atcatcattc acaggcaaca ataaagatac tacgttaaga gcaggagttg 1531621 tgaagaatga atgatcaact gaccgcaatt tatacggaac ttcttctgat gaaagaagaa 1531681 ttacagtcga gattatttga gtattcttgc tttcaggttt ctacaagccc gcaagcagca 1531741 atcaatcaaa aacaaaaagc aactctgatc tatcatatta aagaagaact tcaagacgtt 1531801 ctccttgcat tgtccaaaat cgaaaacggc acattcggat actgtgaaga aactggggcc 1531861 cccattcctc ttgcaaagct ggcagtgctg ccgacggccc gaacagcaaa cgattttctt 1531921 tattctgtcc aatttgagaa aaaaacgctt ccgatatgga aatcaacgga tatcgaatat 1531981 ggtcaggcac tgtatgaata acagtgtctg tccggttaat atgcctgata tttctttact 1532041 ccagtgcttt ttattgataa aatgcataat ggattaaagt aaccgtaaac tggaggaacg 1532101 tttgtgctgt attatatgat tgcactactt attattgcag ccgatcaatt gacaaaatgg 1532161 ctagttgtta agaacatgga acttggccaa agcattccga tcattgatca ggtattctat 1532221 atcacctccc atcgcaatac gggtgctgca tgggggatat tagcgggtca aatgtggttt 1532281 ttctacctca taacaaccgc tgttattatt ggtattgttt attacataca gcgttataca 1532341 aagggacaaa ggcttcttgg cgttgccctc ggacttatgc ttggcggtgc catcggcaac 1532401 tttatcgatc gggctgtcag acaggaagtt gtggatttta tccatgttat tattgtcaat 1532461 tacaattacc cgatatttaa catcgcggac tcttcactat gtgtcggcgt aatgctttta 1532521 tttatacaaa tgctgttgga cagcgggaaa aagaaaaagg agcaatagca tgaatcaaat 1532581 tgatataacc gcttcagaag aacaaaaaag tgagcggatt gataaatttt tggcatcgac 1532641 tgagaatgat tggtcaagaa cccaggttca gcaatgggta aaagacggac aggttgtcgt 1532701 gaacggaagc gcggtgaaag cgaattataa aattcagccg ggtgatcagg tgaccgtcac 1532761 tgtacctgaa ccggaagcgc tcgacgtcct ggcagagcct atggatctgg atatttatta 1532821 tgaggaccag gatgtgctgg tcgtcaacaa acctcgcgga atggttgttc acccagcacc 1532881 cgggcatctt acgggcacac ttgtaaacgg tcttatggct cattgcacag acctttccgg 1532941 aataaatggt gtgatgcgcc cgggtattgt tcacagaatc gataaggaca cgtccggttt 1533001 attaatggtg gcgaaaaatg atatggcgca cgagtcactc gtaaaccaat tggtcaacaa 1533061 aacggtcacg cggaaatata cggcggttgt ccacgggctt atttctcatg atgacggcac 1533121 aattgacgcg ccgatcggac gggataaaaa agaccgtcaa agcatgactg tgacacgtga 1533181 tggcaaaaac gctgtcactc attttcatgt gcttgagcgt tttcaggatt ttacgttagt 1533241 ggagtgccag cttgaaacag ggagaaccca tcaaattcgt gttcatatga aatatatcgg 1533301 attcccatta gcaggcgatc cgaaatacgg cccaagaaaa acaatcgact ttaatggcca 1533361 agcgcttcac gcgggagttt taggttttga ccatccacga acaggagaat atgtcgaatt 1533421 tgaagcgccg cttcccgagg atatggcaga attaatcgaa aacctcagaa aaaacggttg 1533481 acagagggtt tcttttctga aataataaac gaagctgaat agattcttta aaacagtcca 1533541 gagaggctga gaaggataac ggatagacgg gatgcgtgta taggcgcgca ccttgtccta 1533601 aaacccctct atgctctggc aggaggggtt ttttcttcta tatgaactgt gaggtgtcac 1533661 acattgaatc aaaaagctgt cattctcgac gaacaggcaa ttagacgggc gctgaccagg 1533721 attgctcacg aaatgatcga acgcaataaa ggaatgaata actgcattct tgtcggcatt 1533781 aagacaagag ggatttacct ggcaaaacgc cttgcggaac gcattgaaca gattgaggga 1533841 aatcctgtta cagtcggtga aattgatatt actctttaca gagatgatct ttctaaaaaa 1533901 acaagcaacg atgaaccgct tgtaaaaggt gcagatattc cggtagatat tacagatcaa 1533961 aaagtcattc tcgttgatga tgttctgtat accggaagaa cagtcagagc aggaatggat 1534021 gcgcttgttg atgtaggcag accttcctcc attcagcttg cagtgcttgt ggacagagga 1534081 caccgggagc tgccgatccg agcggattat atcgggaaaa acatcccgac atcaaagtct 1534141 gaaaaggtta tggtacagct tgatgaggta gaccaaaacg atctcgtcgc catttatgaa 1534201 aacgaataat agatcacctt tttaagggca atccagagag gttgcaaaga ggtgcacaac 1534261 aaaggcccaa aaagtattcg gcaggtcttt gtatgcctct ttgcgtaaaa aagcaaagag 1534321 gtttttttat acagtcattg agtcatccta aaatgaaagt caacaatcag ggggaaatca 1534381 tcatgagtaa gaaaaaagta aatttagggg tcagggatgt cccgacacct ttctcttggg 1534441 tttcattcag ccttcagcat ttgtttgcca tgtttggctc aaccattttg gttccgaagc 1534501 tcgtcggaat gagtcctgct gtggcgttgg tgacaagcgg catcggaaca ctggcgtacc 1534561 ttcttattac caaaggacaa attccggcgt atctcggttc atccttcgcc tttatttctc 1534621 cgatcattct ggtaaaagcg accggcgggc cgggagcggc aatggttgga gcgtttcttg 1534681 cagggctggt gtacgggctg attgccttat tgattaggca gcttggaaca ggatggctga 1534741 tgaagattct cccgcctgta gtcgtagggc ctgttattat cgtcatcggg ctgggactgg 1534801 caagcactgc agtaaacatg gcgatgtatg ctgatccgaa cgcgagtgag ttggtctaca 1534861 gcttaaagca ctttagtgtc gcaggagtta cgctggcaat tacgattatt tgtgcgattt 1534921 tcttacgagg gtttttaagc ctgattccgg ttctgatcgg aatcatcggc ggatacctgt 1534981 ttgcccttac tcaagggatt gtcaacttcc agccggtgct tgacgcgaaa tggtttgcag 1535041 tgcctgaatt tatcattccg ttcaaagatt attcaccgtc agttacgctc ggcatcgcag 1535101 ccgcaatggt tcctgtcgca tttgtcacaa tgtcagagca tatcggccac caaatggtgc 1535161 tgagcaaggt tgtcggacaa gacttcatta aaaagccagg tcttcatcgc tctattatgg 1535221 gtgacagtgt ggcgacaatc ctcgcttccc tgatcggcgg ccctccgaca acgacttacg 1535281 gagaaaacat tggcgtgctg gccatcacaa gagtattcag cgtctttgtc atcgggggcg 1535341 cggcagtgat tgccctttgc ttcggcttta tcggcaaaat ttcagcgctg atcagttcag 1535401 tgccgtcagc ggtcatggga ggcgtctcct tcctgctgtt cggaatcatt gcttcaagcg 1535461 gcctgagaat gctgattgac aacaaaattg attatgaaaa caacagaaac ctcattatta 1535521 catcagttat ccttgtcatc ggtgtaggag gcgcttttat ccaagtgtct cagggcggat 1535581 tccaagtgtc aggaatggcg cttgccgcaa ttgtcggtgt catcttaaac ctgattcttc 1535641 cgcaggcgaa ggaagagcag gcagacacat ctgaacaaca tcatatttaa aaccttttaa 1535701 tgaaagtcca gagaggcttg gaagggttat gaagagaagg aagcttcaat gctgccctct 1535761 atttaaccat accccgagtc tatcttagac cggggttttt tttcagcctt aagttgaaaa 1535821 gagaggggaa agaacatgaa gcatttaacg acgatgagtg aacttagcac tgaggaaatc 1535881 aaagatttgc ttcaaacagc acaagagctc aaaagcggaa aaacagacaa tcagcttaca 1535941 ggaaagtttg cagcaaacct gtttttcgaa ccgagcacga gaacgcggtt cagctttgag 1536001 gtcgcagaaa aaaagctggg catgaatgtg cttaaccttg atggaacaag cacaagcgtg 1536061 caaaaaggcg aaaccttata tgacacgatc cggacgcttg aatcaatcgg tgtggacgtc 1536121 tgcgtcatca ggcacagtga ggatgagtat tatgaagagc ttgtcagcca ggtgaacatt 1536181 ccgattctga atgcgggaga cgggtgcggc cagcatccaa cacaatcact gcttgattta 1536241 atgacgattt atgaagagtt caatacgttt aaagggctta ccgtctccat tcacggcgac 1536301 atcaagcata gcagagtggc aaggtcaaat gcggaagtgt tgacaagatt gggtgcccgg 1536361 gtcctatttt ccggcccttc ggaatggcag gatgaagaaa atacattcgg cacgtatgtc 1536421 tcaatggatg aagcagttga gtcttccgat gttgtcatgc tgctgcgcat tcaaaatgaa 1536481 cgacatcagt ccgctgtcag tcaggaaggc tatttaaaca aatacggctt gaccgtagaa 1536541 cgggctgagc gtatgaagcg gcatgcgatc atcatgcatc ctgctccggt aaacagagga 1536601 gtggagattg atgacagctt agtagaaagc gaaaaatcaa gaatcttcaa gcaaatgaaa 1536661 aatggcgtat ttatcagaat ggcagtgata cagcgtgcct tacaaaccaa tgtgaaaaga 1536721 ggagaagcag cgtatgtcat atctcattaa aaacggctgg atactaaacg aaaatggtga 1536781 aaaaacacaa gcggatatcc gagtgactgg agaaaccatc accgcaatcg gcaagcttga 1536841 tgcaacggat aatgaaacgg taattgatgc aaaaggtttg ctcgtttcac ctgggtttgt 1536901 tgatctccac gtgcatttca gagagccggg cggagagaaa aaagaaacta ttgaaaccgg 1536961 ggcaaaagca gcggcgcgcg gcggctatac tacagtagca gcaatgccga atacgcggcc 1537021 ggttcctgat acaaaggagc agatggaatg ggtgcaaaac agaattaaag aaacatcatg 1537081 cgtaagagtt cttccatatg catccattac gatcagacaa atcggcgatg aaatgacaaa 1537141 ctttgaagcg ttaaaagaag ccggggcatt tgcttttaca gatgacggcg ttggtataca 1537201 gacagcagga atgatgtatg aagcgatgaa acgggcagcc gcaattgaca aagcgattgt 1537261 tgcacattgc gaggacaact ccttaattta cggagggagc gtacatgagg ggacattctc 1537321 caaagcgaac gggctaaacg gcattccttc tgtgtgtgaa tcggttcata ttgctcgcga 1537381 tgtgctgctg gctgaggcgg caaactgcca ttatcatgta tgccatatca gcacaaaaga 1537441 atctgtcaga gttgtacgcg atgcgaaaaa agcgggaatc agagtgacag cagaagtatc 1537501 gccgcatcat ttgctgcttt gtgatgagga catcccgggg ctggacacaa actataaaat 1537561 gaatcctccg ctccgcagcc cagaagacag agctgcttta attgaaggtc ttttagacgg 1537621 aacaattgat tttatcgcaa cagaccatgc accgcatacg gaagaagaga agaacacaga 1537681 aatgaagctg gcgccattcg gaattgtcgg cttagaaaca gcattcccgc ttctttacac 1537741 acactttgtc aaaaatggca gctggtcact gaagcagctg attgactaca tgacaatcaa 1537801 gccatgcgaa gcgttcggtc tcccatatgg aacattacaa acggggcaag ctgcggacat 1537861 tacgttaatc gatttagaaa aagaagcagt tatagacaaa gagacatttt tatcaaaagg 1537921 aaaaaataca ccattcaacg gcatcagttg caccggctgg ccggtcgcta caattgcggc 1537981 agggaagctt gcttatgaag aggggagact tgtcaaatga agagacgatt agtactggaa 1538041 aacggagcgg tattcgaggg agaagctttc ggaagcttag aacacaacat gggagaagtc 1538101 gtttttaata ctgggatgac aggctatcag gaaattttat ctgatccttc ttactgcgga 1538161 cagatcgtaa cattaacata cccgcttatc ggaaattacg gcattaaccg tgatgatttt 1538221 gaatccatta ccccttttgt caaagggctg atcatcaaag aattatgtga gctgccttcc 1538281 aactggcgtt cagcatacac cttagacgag tatttaaaaa tgaaaaacat tcccggactc 1538341 cagggaattg atacaaggaa gctgacaaga atgatccgca cggcaggcgc gctaaaagga 1538401 acattcgctt catctgatga agatatcgaa gcagtgctga aaagactgaa cgaaacggaa 1538461 ttgccaagaa atcaagtatc ccaagtatca gcaaaaacag catatccgag cccgggaaga 1538521 ggcaaacgca ttgtcttggt tgacttcggc atgaaacacg ggattctaag agagctgaac 1538581 aaacggaaat gtgacgtcat cgttgtgcct tacaacatta cagcggaaga ggtgcttcag 1538641 ctgaaaccgg acggtatcat gctttctaac ggacctggag acccgaagga tgtgcctgaa 1538701 gcgattgaaa tgattaaagg tgttcttgga aaagtgccat tattcggaat atgtctcggc 1538761 caccaattat tcgcgctggc gtgcggggcg aatactgaaa aaatgaaatt cggccacagg 1538821 ggctcaaacc acccggtaaa agagctggct acaggaaaag ttgccttaac atctcaaaac 1538881 catggatata cagtttcgtc tatcagtaaa acagaactgg aagtgacgca tatcgcaatt 1538941 aacgacgata cgattgaagg gctgaagcat aaaacattgc cggcatttac ggttcaatat 1539001 catcccgaag cctcacctgg tcctgaggat gccaaccatc tatttgacag attcatcgaa 1539061 atgatcgaaa caacagagaa agaaggggaa gcggtatgcc aaaacgcgta gacattaaca 1539121 aaattttagt aatcggatct ggaccgatca tcatcggcca agcagcagaa tttgactatg 1539181 cgggaacaca agcctgtctt gctttgaaag aagaaggcta tgaagtcatc cttgtcaact 1539241 caaaccctgc aacgatcatg acagatacag aaatggctga ccgggtttac atcgaaccgc 1539301 tcacacctga attcctgaca cgaatcatca gaaaagagcg cccggatgcc attcttccta 1539361 cactcggagg ccaaaccggt ttgaatcttg cggttgagct ttctgaaaga ggcgttttgg 1539421 cagaatgcgg cgtcgaagtg cttggcacga aactgtctgc gattcagcaa gctgaagacc 1539481 gtgacttgtt cagaacatta atgaatgaac tgaatgaacc ggtgcctgaa agtgagatta 1539541 tccactccct tgaagaagca gaaaaattcg tcagtcaaat tggattccct gtcattgtcc 1539601 gcccggcata tacattaggc ggaacaggcg gaggcatctg ctcgaatgaa acagagctaa 1539661 aagaaatcgt tgagaacggc ttgaaattaa gcccggtaca ccaatgtctg cttgaaaaaa 1539721 gcatcgccgg ctataaagaa atcgagtatg aagtcatgag agacagccag gatcacgcca 1539781 ttgtcgtttg taacatggaa aacattgatc cagttggaat ccatactgga gacagtattg 1539841 ttgtcgcgcc gagccaaacg ctcagcgatc gcgaatatca gctcttgcgg aatgtatcgt 1539901 taaaactgat tcgcgcgctt gggatcgaag gcggatgtaa tgtccagctc gccttagatc 1539961 cagacagctt ccaatattac attattgaag taaatccgcg tgtcagccgt tcatctgccc 1540021 ttgcatcaaa agcaacgggg tacccgattg caaagctcgc tgctaaaatt gcagtcggac 1540081 tttcattaga tgaaatgatg aacccggtga caggaaaaac atatgcagca tttgaacctg 1540141 ctcttgacta tgtcgtatcc aaaattccgc gctggccgtt tgataagttt gaatcagcaa 1540201 acagaaagct tggcacgcaa atgaaagcga caggtgaggt catggcaatc ggccgcacgc 1540261 ttgaagagtc attgctgaag gcagtgcgat cactggaagc ggatgtgtat catcttgaat 1540321 tgaaggacgc cgctgacatt tcagatgagc ttcttgaaaa gcgaattaaa aaggccggtg 1540381 atgaacgctt attctactta gctgaagcgt acagaagagg ctacacggta gaagacctcc 1540441 atgaattttc cgctatcgat gtcttcttct tgcataagct gttcggaatc gtacagtttg 1540501 aaaaagaatt gaaggccaat gcgggcgata cagatgtgct gagacgggca aaagaactcg 1540561 gcttctctga tcagtacatc agccgtgaat ggaaaatgaa agaatctgag ctttacagct 1540621 tgagaaaaca agcggggatt gcgccggtat tcaaaatggt agatacatgc gcggcggaat 1540681 ttgagtcaga aacgccatac ttctatagca catatgaaga agaaaatgaa tctgtcgtta 1540741 cagataagaa aagtgtgatg gtgcttggtt cgggtccgat tcgaatcggt cagggtgtcg 1540801 agttcgacta tgcgacggtt cactctgtat gggcaattaa acaagcaggc tatgaagcca 1540861 ttattgtcaa caacaacccg gaaaccgttt caacagactt cagcatctca gacaagctgt 1540921 attttgaacc gcttacgatt gaagatgtca tgcacatcat tgacctcgaa cagccaatgg 1540981 gcgttgtcgt acaatttggc ggacaaactg cgattaacct tgctgacgag ctttctgcac 1541041 gcggagtgaa aatccttgga acttcattag aagatttaga ccgtgccgaa gaccgggata 1541101 aatttgaaca agcgcttgga gaacttggtg ttcctcagcc gcttggcaaa acagcgacat 1541161 cagttaatca ggcggtaagc atcgcaagtg atatcggtta tccggtactg gtacgccctt 1541221 cctatgtact tggcggccgg gcgatggaga ttgtttacca tgaagaggaa ctgcttcatt 1541281 acatgaaaaa tgcagtcaaa atcaatccac agcaccctgt attaattgat agatacttga 1541341 ccggaaaaga aattgaagtc gatgcagtat ccgacggtga aacagtcgtc attccgggaa 1541401 ttatggagca cattgaacgt gcgggcgttc actccggaga ctcaatcgct gtttatccgc 1541461 ctcagtctct cacagaggac attaagaaaa aaattgaaca atacacgatc gcattggcta 1541521 aagggctgaa tattgtcggt ttgctcaata ttcaattcgt cttgtcgcaa ggcgaggtgt 1541581 acgtgctaga agtgaatccg agatcaagca gaaccgtacc gtttttaagc aaaattacgg 1541641 gtatcccaat ggcgaatctc gcaacaaaaa tcattcttgg tcaaaagctg gctgcgtttg 1541701 gctatacaga gggccttcag cctgaacagc aaggtgtatt tgtaaaagcg ccggtcttct 1541761 cctttgccaa gctgagaaga gtggatatta cgttagggcc tgaaatgaaa tcaacaggtg 1541821 aagtcatggg gaaagattcg acacttgaaa aggcgctcta caaagccttg atcgcttcag 1541881 gtattcaaat cccgaactac ggttccgtgc ttttaacagt agctgataag gacaaagaag 1541941 aagggcttgc cattgctaag cggttccacg cgatcggcta caacatttta gcgacggaag 1542001 gaacggcagg ctacctgaaa gaagcttcca ttccagcgaa ggtcgtcgga aaaatcggtc 1542061 aggatggccc gaacttgctt gatgtcatca gaaacggaga agcgcagttt gtcatcaata 1542121 cgctgacaaa aggaaagcag ccggcaagag acggttttag aatcagacgt gaatcagtag 1542181 aaaatggtgt tgcctgccta acatctttag atacggcaga ggcgatattg cgagtgctgg 1542241 aaagcatgac attccgtgct gatcaaatgc cggcagtcaa cacaaatcag gaggcggcag 1542301 tcactatatg aaaaaagcgt atttgacagt atgttctaac cagcaaattg cagaccgggt 1542361 gtttcaaatg gttctgaaag gggagcttgt ccaagggttt acaacccctg gacagttcct 1542421 tcatcttaaa gtgagcgaag cggttacgcc tcttttgaga aggccgatca gcatcgcaga 1542481 cgtcaacttt gaaaaaaatg aagtcaccat catttatcgg gtagatgggg aagggacaag 1542541 actcttgtca ctgaagcagc agggagaact tgtggatgtc ctcgggcctt tgggaaatgg 1542601 ctttcctgtt aatgaagttc aacccggaaa gacggctttg ctggtaggag gcggagtagg 1542661 tgtgccgcct ctccaagagc tgtcgaaacg cttgattgaa aaaggggtaa atgtcatcca 1542721 cgttttagga ttccaatcgg caaaggatgt tttttacgag gaagaatgcc ggcagtacgg 1542781 agacacgtat gtggcaacag ctgacggaag ctacggggaa accggatttg tcacagatgt 1542841 gattaaacgg aaaaagctag agtttgatat cctcctcagc tgcgggccga caccgatgct 1542901 caaggcgtta aaacaggaat atgcccataa agaagtatat ctgtccatgg aggaacgaat 1542961 gggctgcgga atcggcgcat gcttcgcgtg tgtgtgccat acaaacgaaa gtgagacatc 1543021 ctatgtaaaa gtatgtctcg acgggcctgt atttaaagct caggaggtgg cgctgtaatg 1543081 ctagaggtga aattgccggg acttgatttg aaaaacccaa tcattcctgc atcaggctgc 1543141 ttcggttttg gaaaagaatt ttcacgtttt tatgatttgt cttgtcttgg agctatcatg 1543201 attaaggcta cgacaaagga gccgcgcttt gggaatccga cgccgcgggt agctgagact 1543261 ggtgctggaa tgctcaatgc gatcggtctc caaaatccgg ggctggatag tgtgttgcat 1543321 catgagctgc cgtggcttga gcagtttgat acaccgatca ttgccaatgt cgcaggttct 1543381 caagtcgatg attatgttga agtcgcagaa catatcagca aagcgcctaa tgttcatgct 1543441 cttgaattga atatttcctg cccgaatgtg aaaacaggcg gaatcgcttt tggcacgaat 1543501 cctgaaatgg ctgccgattt gacaaaagcg gtgaaagagg tttcggatgt acccgtttat 1543561 gtgaagctat ccccgaacgt ggctaatatc acagaaattg cattagcgat cgaggaagcg 1543621 ggagcggacg gtcttacgat gatcaacaca ctaatcggca tgagactcga tttaaaaacc 1543681 ggcaaaccga tattagcgaa taaaacaggg ggactttcgg gccctgctgt gaagccggtt 1543741 gccattcgca tggtgtatga agtcagccag atggtcaaca tcccgattat cggaatggga 1543801 ggcgtgcaaa cggctgaaga tgccctggaa tttcttctcg cgggagcaag cgcagtcgct 1543861 gtcggaacag caaactttgt gaatcctttt gcatgtccag agattattga acagctccca 1543921 tctgttttgc tccaatacgg ctatcaatca attgaagaat gcatcggaag gagctggaat 1543981 catgaaaaac aacctgccca tcatcgcgct tgattttgcg tcagctgaag aaacacttgc 1544041 gttcttagcg ccttttcagc aagaaccgtt atttgtaaag gttgggatgg agctttttta 1544101 tcaagaaggg ccatctatcg tgaaacaact aaaagaaaga aactgcgagc tatttttaga 1544161 tctaaagctt catgacatcc cgactactgt aaacaaagcg atgaagcgcc ttgccagtct 1544221 tggagtagac ctcgtcaatg ttcatgctgc cgggggcaaa aaaatgatgc aggcagctct 1544281 cgaaggctta gaagaaggta cgccggctgg aaaaaaacgt ccgtcactta tcgcggtaac 1544341 ccagctgaca agcacatctg aacaaatcat gaaagatgaa ctgctgatcg aaaagtctct 1544401 gattgatacg gttgtgcact acagcaaaca ggcggaagaa agcggactgg atggagtggt 1544461 ctgctctgtt catgaagcaa aagccattta ccaagcggtg tcgccttcat ttctgactgt 1544521 cactccgggg atcagaatgt cagaggacgc tgcgaatgac caagttcgcg tagcgacgcc 1544581 tgccattgca agagagaaag gttcatcagc gattgtagta ggacgctcga ttacaaaagc 1544641 ggaagacccg gtaaaagcct ataaggctgt cagacttgaa tgggagggaa tcaaatcttg 1544701 aaacaaatca tcgcaaaaca tctattagac atccaagctg tatttttacg cccgaacgag 1544761 ccgttcacat gggcaagcgg cattttatca ccgatctact gtgacaaccg ccttacgcta 1544821 tctttcccag aggtcagaaa cgatgttgct tcaggtatca gcaagcttgt taaagagcat 1544881 tttcctgaag ctgaaatgat tgcgggaaca gcaactgccg gtattcctca tgctgctctt 1544941 gcggcggacc atttgaatct tccgatgtgt tatgtgagga gcaagccgaa ggcgcacgga 1545001 aaaggcaatc agattgaggg agctgtgcaa gaagggcaaa aaacagtcgt cattgaagac 1545061 ttaatttcca caggaggcag cgtgcttgaa gcttgtgcag ctttacaagc ggccggctgt 1545121 gaagtgcttg gtgtcgtctc aatctttacg tacggacttc ctaaagcgga ggaagccttc 1545181 gcaaaggcag aactgccata ctactcatta accgattatg atacgctcac agaggtcgcg 1545241 cttgaaaacg gaaatattca ttcagatgat ctaaaaaagc tgcaaacatg gaaacgaaat 1545301 cccgagtcaa aagattggtt taaaaaataa aaaataaatt caaatgatgt aaagaggctt 1545361 caaagccttg ctgtacttga aaacaggctg tgaggcctgt ttttttatta atcctataaa 1545421 aaaagtcggg ttgacttatg ttagaattgt gctaaaattt actacaaatc taaaaactta 1545481 tcaagagcgg ctgagggact ggacctatga agcccggcaa cctgcatagt ttgtaaggtg 1545541 ctacttccag caaaatgaat tccattttga aagataaggg ctgcatgctg ttcctgtctt 1545601 tctttccgcc ggattgaaag ttttttattt taagaggtaa aaaggctatc tgtatatcag 1545661 cagccgcgaa tcacattaca tgggaaaaga caaccggcag aaagctactg tttgtttgtc 1545721 tccgaaagga ggaaagaaga aatgttaacg tatgataatt gggaagaacc aacgattaca 1545781 tttccggaag acgatcctta taaaggagcg ctgtcagttt taaaatgggc atacggccat 1545841 tacggcgatc agcttgttta tgcctgcagt ttcggaattg agggaatcgt tctgattgac 1545901 ttaatttata aagtgaaaaa agacgcagag attgtgtttc ttgatacagg acttcatttt 1545961 aaagaaacct atgaaacaat tgaacgagtg aaagagcgtt atccgggtct taatatcatc 1546021 ctgaaaaaac cagatctcac ccttgaggaa caagccgaag aacatggtga caaactatgg 1546081 gaaagagagc cgaatcagtg ctgctatctt agaaaggtcg ttcctttaag agaggcgctt 1546141 tcaggacatc cagcctggct ttccggcctg cgccgtgatc aagggccaag ccgtgccaat 1546201 acgaatttct taaacaaaga tgaaaaattc aagtcagtaa aagtttgccc gcttatccat 1546261 tggacttgga aagacatttg gagatataca tcccggaatg aactggacta caatccgctt 1546321 catgaccaag gctatccaag tattggctgt gcgccttgca cttctcccgc ttttacagca 1546381 gaagatttgc gctcaggcag atggaatggt atggcgaaaa cagaatgcgg actgcatgaa 1546441 taaggagctg caaaatggaa ttagccgcta ttttatttag cttgtttttc gcgatgaata 1546501 ttggtgcaag cggcgctgca gcttcgatgg gggttgctta cggctccgga gccatcaaaa 1546561 agaaaactta cgctttgatc ctatgcgcag tcggtgtctt tgccggggcg gtcattggcg 1546621 gaggcgaggt tgtaaaaaca atcagctccg gcattattcc tgagcagacg attacactga 1546681 cgattgtttg catcattatt ggagctgctg ccctgtcgct ctttactgct aatctgctcg 1546741 gcattccttt gtcgacaagt gaagtaacag tcggcgcggt tgtcggcgtg ggagtggctt 1546801 ataaagtatt gtttgtgaac aatcttctga tcattgtgtc attttgggtt tttgtcccgc 1546861 tgttcgcttt cggcttcacc tatttcgtat ctaagctgtt tcgttatttt aagattgaag 1546921 taaaatcttc taaaaagcaa aaaatcctcg gcattgtttt gttagttgcc ggatttttcg 1546981 aagcattctc tgccggcatg aataacgtgg cgaatgctgt tggcccgtta gtagctgccg 1547041 gtgtgcttga tgtcggaaaa ggaaccttgt atggaggagc ttttgttgct cttggcgcac 1547101 tgttattagg ccggcgagtg ctagaaacaa acgggaagaa aattacgagg ttctccaaag 1547161 gggaaggcat tctcttatcc ggtacaggag cgggactggt gatcatcagt tctgtatttg 1547221 ggatgccggt gcccttggcg caagtcacgt catcgtctat tatcggaata ggcatggcga 1547281 aaaacggtcc gaacgtgttc cataaacaag ttgttcaaac gatgctgaag gtatggatcg 1547341 tatcgccgtt tttatcttta tcgatttctt atctgcttgt atccttgttt ttaaaagcag 1547401 attattattc gatctttatc atggtaagtg tgcttttagc ggcgggcggt gccatcagcc 1547461 tgacaaaggc cattcgtaaa gagagacgct cagtccacga acaaggcggg ggaatctgat 1547521 cattaatctg agtaatttta taagttaact aggaggagat ggatattatg agcttagcac 1547581 cacacggagg aacattagta aacagagtag atgaatcata tgatgtgagc ggcattcaaa 1547641 aagaaattga acttgattta atttctttcg cggatttgga attgatcggt atcggtgcat 1547701 acagcccgat tgaaggtttc tttaatgaaa aagattacgt atcagtggtc gaaaacatgc 1547761 gtctttcttc cggcgttgtc tggtctcttc caatcacgct tccggtcgat gcgcaaaaag 1547821 cagcggaact gtcacttggt gaaacggtaa agttaacgta tgaaggagaa acttacggcg 1547881 ttatccaaat cgaagacctg tacgtgcctg acaaacaaaa agaagctgtc aatgtgtaca 1547941 aaacagatga acaggagcat cctggtgtta aaaagctgtt cagccgcggc aatacatatg 1548001 tcggcggacc gattacgttg attaaaaaag cttcaaaaca gttccctgaa tttacatttg 1548061 aaccgtcaga aacgagacgc cagtttgcgg aaaaaggctg ggaaaccatt gtcggtttcc 1548121 aaacaagaaa ccctgttcac agagcgcatg aatacattca aaaaacggct cttgaaacag 1548181 tagacggctt gttcttgaat ccgttagtag gtgaaacaaa atctgatgac attccagctg 1548241 atgtacggat ggaaagctac caagtgcttc ttgatcatta ttacccgaaa gatcgtgttt 1548301 tccttggtgt ctttttagcg gcgatgcgtt atgcaggccc gagagaagca attttccacg 1548361 cgcttgtcag aaagaactac ggctgcacac atttcatcgt cggccgtgat catgcaggtg 1548421 taggcgacta ttacggaaca tacgaagcac aggaactgtt tgacacattt aaacctgaag 1548481 aactcggaat tacaccgctg aaatttgagc acagcttctt ctgtaaaaaa tgcggaaata 1548541 tgggaacagc aaaaacttgc cctcatggca gagagcatca cgtcatttta tcaggcacta 1548601 aggtaagagg tatgctgaga gacggtgtgc tgccgcctgc tgaattcagt cgaaaagaag 1548661 tagtagaagt gttaatcaaa gggatgaaga aaaaagaaga agtaggcgta tcttaaggag 1548721 gactggcagt gacaaatcgc gatattgtat ggcatgaagc ctctatcaca aaagaagagt 1548781 atcagcaaaa aaacaagcat aaaagctcca ttctctggct gacagggtta agcggctcag 1548841 gcaaatcaac cattgccaac gccgctgcga gagaattgtt tgagcaaggc taccaagtca 1548901 ttgtgctgga cggggataat atccgtcacg gcctaaatag ggatcttggt ttttctgatg 1548961 aagaccgaaa agaaaacatc cgccggatcg gagaggtggc gaagcttttt gttcagcagg 1549021 gaaccattgt gattactgct tttatctctc ctttccgcga ggacagacaa caggttcgcg 1549081 agcttgtgga agcgggcgaa tttaatgaag tctacattaa atgcgacctt gatatttgtg 1549141 aacaaagaga tccgaaaggg ctttacaaaa aagcaagaaa cggcgagatt ccgttcttta 1549201 caggaattga ttctccttat gaagaaccgg aagctccaga gctcgttctt gattcaggac 1549261 agcatgaccg tgaagcgtgt aaaaatcagc tgatcgagtt tgttaaacaa aaattgagct 1549321 gaatatgatc tgctgcgttc ttctcagatg ccggaatgca agcgagaaca tcatcacagc 1549381 gaatcttctg gaagaactcg aatagatcgg gggaaatacg atggggaaag tatatattgt 1549441 aggagcgggt cccggtgacc ctgatctgct gacaattaaa gcgctgaaag ccattgaaaa 1549501 agctgatgtc atcttatatg acagattagt aaataaagag attttacaat atgccaaaga 1549561 gcaagcagac ctgatctact gcgggaagct tccggatttt catacgatga agcaggaaac 1549621 catcaatcga tttcttgtga agtatgcgca aaaagggaaa atggttgtca gactgaaagg 1549681 cggagaccct tttgtgttcg ggagaggagg ggaagaagcg gaatgcctct ctgaaaatgg 1549741 aattccgttt gaaatcattc ccggcattac gtctggaatc gcggcagccg cttatgccgg 1549801 gattcctgtt acccatcggg atgcgggctc taacgtcgct tttgtaacgg gtcactataa 1549861 aaaagaagaa gattttgagg aaaagtggaa agcgctggct acaggaattg atacacttgt 1549921 catctatatg ggtatcaaaa acgtgcagca gattgaaaga aaactccttg aaaatggccg 1549981 ggacggttct acgccagcag cctttattca ttgggggaca acggacaagc aaaaatctgt 1550041 tttttgtaca gttgacaccc tttcagaaac ggtgataaaa gaaaacatta caaatccgag 1550101 tttaattgtc attggaaatg ttgtaaatta tcactataag ctggaatggt ttgaatctga 1550161 actaaaaaaa caagatttaa gcgaggcgtt gtaaaaatga aacaagcaat tttatatgtc 1550221 ggccacggca gccgggtcaa aaaagcgcag caagaagccg cagccttttt ggaaggatgc 1550281 aaggcccaca tctctgtgcc agtacaagaa atcagctttt tagagcttca ggagccgaca 1550341 attgagacag gatttgaagc atgtgtgaag caaggtgcca ctcatatcgc agtggtgcct 1550401 ctgcttcttt taacagctgc gcatgcaaaa catgatattc cggaagaaat tgtccgtgtt 1550461 gcatctcgat atccatcagt ccgtatttca tacggaaagc cgatcgggat tgacgaagaa 1550521 gtagtcaagg ctgtatatca ccgaatgaaa gacataggtg ttccgtatga aaatgccaga 1550581 gtggtgctca tcggaagggg aagttcagat ccagacgtca aaagagacgt aaccggaatt 1550641 gctaatcttc ttcaggaaat ggttccagtg aaggaagtca ttccgtgctt tttgacagca 1550701 tgcggcccta attacaaaga ggttttttca gaacttgaaa aagatgacgg cataacaacc 1550761 tttatcgttc catatttgct ttttacgggt atgctgatga atgaaatcga acgagaggtt 1550821 cagaaattaa aagcccataa tccgaacgtc tacctctctt cctatatcgg ttttcatcct 1550881 catgtgaaaa acgcattttt gaaccgtgtg agagaaactg cggcaaattc tgagggacaa 1550941 tttgattttg atggaggttc atatgcttcc gctgcacatt agcctggaaa agaagaaggt 1551001 tgtgattgcg gggggcggaa gcatcgctct cagaaggctg aaaacggtga tttctgaggg 1551061 agctgatata acgcttgtca gtccggatgt ggaaccggaa atcaagcaaa tggcagaaga 1551121 gcggcgtatc aaatgggaaa aacggacaat tgaaaaagaa gattatctca atgctttctt 1551181 cattattgct gcgacggata atgcggcagt gaacaaagaa attgcccaat ccgcttcgcc 1551241 ttttcagctt gtcaattgtg tcagtgacgc tgagcttggc aatgtatata tgccgaaaat 1551301 cgtaaaaaga gggcatgtca ctgtgtctgt ttctacaagc ggagccagtc caaagcacac 1551361 gaaagagctt gctgaaaacg tggataagct gattgacggc gattttgttg ctgaagtgaa 1551421 caggctttat cagatgagaa gaaagaaata agccagagca tacaaatgct ctggcttttc 1551481 tttatgcggc tcagcttttt ttgagcttga tgacagtatc agcatcaggc gtgacaaaga 1551541 cggtatgctg gctgtcataa gtgacgaaac cgggtttcgc gccgtttggt tttttgacat 1551601 gcctgatttt tgtataatct acaggcactg aacttgaatc tttagctttt gaaaaataag 1551661 ctgcaattgt cgcggcttcc atgattgttt gctcatcagg ttcgctgctt ctgatcacaa 1551721 cgtgggagcc gggaatgtcc ttcgtgtgaa gccagatatc gtctctggcc gccactcttg 1551781 tcgttaaata ttcattttga cgattgttct tacccactaa aattgtcagc cctgaggtgg 1551841 attcatatgt ttctaacacc ggattgtgcg gtttttgctt tttctggcct ttttgctgct 1551901 tagggcgtaa atatttgccc tcaacaagct cttccctgat ttcgctgata tcccggggag 1551961 aagcggacga aagctgctga atcagctgat caaaatattc gatctcttcc tgtgccagcc 1552021 tgatttgctc ctcgacaact gcgaccgaat ttttcgcttt ctgatacttc gtgaaatagg 1552081 cctgtgcgtt ttcagaaggc gttttgttcg ggtttaaagg aatcgtgatt gtcgggcttt 1552141 cttcatcata ataattgatg acctcagcct gtttatcacc ttttttcagc atatataaat 1552201 tagcggttaa aagctctccg taaagctgaa attccttcgc gttttccgaa tactccaggg 1552261 ttttctctaa ttttttgatt ttgttggcat tcttcttccg ttcgttcaca acaaaacgct 1552321 caagatcctg agcctgttgc ttaacccggt ctcgttcagc ttttccgaaa taaaaacggt 1552381 cgagcagttc gcttaatgaa tcaaaacggc gcgcttcgcc ctttagatga gtcagctcca 1552441 gcagataaaa atattccttt ccgtttacag tcgtaatgtt gggaatgaaa cggtgctctt 1552501 tcacttcggc aaacagtgcc agcaacgctt ttggcagtgt gactttgttg gcaaggcctg 1552561 ctctgtgaac cgcttctttg gcgaaaagcg gagacacgcc tgaaaagtgg tcgacaattt 1552621 gtttatcaag ccttccttct tgaaagctga ggtgacgcaa aatatcatct tctgacgcct 1552681 caagaggcga tattttgtcc tgagcaggcg gaagcttata atcttggccg ggcagtactg 1552741 tacggtagct gttcattgac ggtgataaat gcttaagtcc gtcgataatc acattttctg 1552801 ctgcgtcagt caaaatgata ttgctgtggc ggcccataat ttctacataa agctttcgta 1552861 cggtttcatc gccaatttcg tttcggcttt tgatatgaaa aatcataatg cggtctaagc 1552921 ccgcttgttc aattttctca atgaatccgc cttcgatatg ctttctcagc aacatgcaaa 1552981 acattggcgg ttcgcttgga ttttcataag cttgtgccgt gatatgcacc cgtgaatagc 1553041 tcggatgtgc cgataataat agtttttggt tttttccctt ggcacggatg tggaaaatca 1553101 catcgtgctt atatggctga tggatttttg taattcgtcc gcccattatt ttctcgttaa 1553161 gttcgtgtgt cattccgtat gtaaacatgc catcaaacga catatgcaat acaccctctc 1553221 attcttcctg cattcgataa ttatagcatg aaatgggacg agtcagaata agcatgctta 1553281 tagagtgata tctctataag agagcagggg agtggacgag cggaatgaag tttcatgaaa 1553341 tgggacaaac agatttacta gaggcaacca atacgtccat gaaacaagga ttaacagaaa 1553401 aagaggtaaa aaaacgcctt gacaagcatg gaccaaacga gctgcaagaa gggaaaaaaa 1553461 cttcagcgct tctcttgttt ttcgcgcagt tcaaagattt tatggtgctt gtgcttctgg 1553521 cggcaacgtt aatctcagga tttcttggtg aatatgtaga tgcggttgcg attattgcga 1553581 ttgtgtttgt gaatggcata ctcggtttct ttcaagaaag gcgtgctgag caatctcttc 1553641 aggctttaaa agagctttca acaccgcacg tcatggcact cagggaagga agctggacaa 1553701 agattccttc taaggaactg gtgccgggtg atattgtgaa atttacgagc ggggacagaa 1553761 ttggcgcaga cgttcgaatt gttgaagcga gaagccttga aatagaagaa tcagcgctaa 1553821 ccggggaatc aatcccggtt gtgaagcatg ctgataaatt gaaaaaaccg gatgtttcac 1553881 tcggcgatat taccaatatg gcatttatgg gtacgattgt gacccgcggc agcggtgtcg 1553941 gggttgtcgt cgggacagga atgaatacgg ctatggggaa aattgccgac atgcttgaat 1554001 cggcagggac attgtcaacc ccgctgcaaa gaagactgga gcagctcggg aagattttga 1554061 ttgttgttgc attgcttctg accgtacttg tcgttgctgt cggtgttatt cagggtcatg 1554121 atctgtacag tatgttttta gcaggtgtct cgttagcggt agccgctatt ccggaggggc 1554181 tgccggcgat tgtgacagtg gcgctttcgc ttggtgtaca gaggatgatt aaacaaaaat 1554241 ccattgttag aaagcttcct gctgttgaaa cgcttgggtg tgcgtctatc atttgctcag 1554301 ataaaacagg gacaatgacc caaaacaaaa tgacagtgac gcatgtctgg tccggaggga 1554361 aaacatggag agtggcaggg gccggctatg aaccgaaagg aagcttcaca ctaaacgaaa 1554421 aagagatcag tgtcaatgaa cataagccgc ttcagcagat gcttctgttc ggagcgcttt 1554481 gtaacaactc caatattgag aaaagagacg gcgaatatgt gcttgacgga gatccgacag 1554541 agggagcgct gctcaccgcg gcaagaaaag gcggtttttc aaaggagttt gttgaatcta 1554601 attacagagt gattgaagaa tttccgtttg attccgcacg gaaaatgatg actgtcatcg 1554661 tagagaatca agacagaaag cgctatatca ttacaaaagg tgcgccggat gtactcatgc 1554721 agcgatcttc ccgtatttat tatgatggct cagcggctct tttttcaaat gaaagaaaag 1554781 cagaaacaga ggcggtatta agacatttgg catcacaggc gctcagaacg atagcggtcg 1554841 cctacaggcc gataaaagca ggcgaaacac cgtcaatgga gcaggcggaa aaagatctga 1554901 ccatgcttgg cctttcaggt atcattgatc ccccgcggcc ggaagtcaga caggcgatta 1554961 aagaatgccg tgaagcggga attaagaccg tcatgattac aggtgatcat gtagaaaccg 1555021 ctaaagcgat agcgaaagac ttgcgcctcc ttccgaaaag cggcaaaatc atggacggca 1555081 agatgctgaa tgaactttct caagaagagc tttctcatgt ggtggaggat gtgtatgtat 1555141 ttgcccgcgt ttcccctgaa cataaactaa aaatcgtaaa agcctatcag gagaacgggc 1555201 atattgtggc gatgacggga gacggcgtca atgatgctcc tgccattaaa caggctgata 1555261 tcggcgtctc tatgggcatt accgggacag atgtggccaa agaagcatca tctcttgttc 1555321 tcgtggatga taattttgcg acgattaaat cagcgataaa agaaggcagg aacatctacg 1555381 aaaatatcag gaagtttatc agatacctgt tggcgtctaa cgtcggagaa atccttgtca 1555441 tgctgtttgc gatgctgctt gcccttcctt taccgctggt tccgattcag attttgtggg 1555501 tcaacttggt gacggacgga ttgccggcaa tggcgctcgg catggatcag ccggaaggag 1555561 acgtcatgaa gcgcaagccc cgtcatccga aagaaggggt atttgcccgc aagctaggat 1555621 ggaaggtcgt ttccagagga tttttaatcg gagttgccac tattttagcg tttatcattg 1555681 tgtaccaccg caatccggaa aacttggctt atgcccagac gatcgcgttt gccacattgg 1555741 tgctcgctca gcttattcac gtgtttgact gccgcagcga aacttctgtt ttctctagaa 1555801 atccgtttca aaacctgtat ttaatcggcg cggtattgtc atccattttg ctgatgcttg 1555861 tagtaatcta ctatccgccg cttcagccga ttttccatac tgtagccatc acgccggggg 1555921 actggatgct cgtcatcggt atgtccgcca tccctacttt tttgctggcg gggtcacttt 1555981 taacaagaaa aaaataaatt catatgatat aatcttaggg gtaatagcgt gtctattgcc 1556041 cttttattat gagaacaggg aagaattggg tgttttaaaa tgatacgaag tatgacaggc 1556101 ttcggcagtg caagcaaaac acaagacgat ctctctgtaa gcgttgaact taaatctgtg 1556161 aactacagat ttaaagaagt gaacgctcgt ttgccaaggc ctttgctata ttttgaagat 1556221 aagctgaaac agaccattct gcagcatatt cagcgcggaa gaattgagct tttcgtatcc 1556281 gttgacagcg atatgcttgt tgagaaaagg cttgaaattg attggccgct gctcgatgag 1556341 tttgtcgcag ccgcgagaga tatgaagaag cggtatcaat tgtctgcaga gcccgatgta 1556401 atggatttct ttaagcttga tcatgtcgtc caggttcatg aagaacagac gcaaaatgac 1556461 aagctggagg cgttgatcat cgatgctgca gaagaagcgg taaaaggtct ctgtgaaatg 1556521 cgtgaaaaag aggggctgct cttagcgaaa gactgcctga tgcatattga tcagcttgaa 1556581 gagctggtga gagaaactga attgctggct gcagatgtcg tatctcgtta ccgggaacgg 1556641 ctgtatgcca gaatcaaaga atggactgaa gacgtattag acgagagccg gcttgtaaca 1556701 gaatgcgcta tttttgcaga ccgctctgat atcactgaag agattacaag gctgaagagc 1556761 cacttcgccc agtttcgtga tatattagct agtggcggag ctgtcgggcg caaactcgac 1556821 tttcttgttc aggagctcaa tcgggaagca aatacgatcg gctcaaaagc aaatgatcat 1556881 cagatcacaa agcttgtcgt tgaaatgaaa agttctattg aaaaaataaa agaacaagtg 1556941 caaaatatag aatagtgact gtgcgtattg tttacagacg gtcttactag gctaaactag 1557001 agacgtctat tttacagggg gaacgtagaa gatgacgatt aaactgatta atatcggatt 1557061 tggcaatatc atctccgcca atcggatgat ttcgattgtc agcccggagt ctgcgccaat 1557121 caaacggatg attcaggatg caagagaccg cggaatgcta attgacgcta catacggacg 1557181 aagaacccgt gcagttgtcg tcatggatag tgatcacatt atcttatctg ccgtccagcc 1557241 tgagacagtt gcacacagac tttctgttaa agaagaaatt atggatgaag ggcaggggta 1557301 attgccgcat gaaagaaaga gggttattaa tcgttctctc aggtccctca ggagttggta 1557361 aaggaacggt tcgacaagcg atcttttcgc aggaagacac aaaatttgaa tattcgattt 1557421 cagtaaccac aagaagtcca agagagggcg aagtgaacgg agtcgattat tttttcaaaa 1557481 caagagacga attcgagcaa atgattgcgg acaacaagct gcttgaatgg gcagagtatg 1557541 tcggcaatta ttacggcacg ccagtcgatt atgttgaaca gacgcttcaa gatggaaaag 1557601 acgtcttttt agaaattgaa gttcaagggg ctcttcaagt gagaaatgct ttcccggaag 1557661 gcctgtttat tttccttgcg cctccaagcc tttctgaact gaaaaacaga atcgtgacac 1557721 gaggaacaga aacagacgct ctgattgaaa atcgaatgaa agccgcaaaa gctgagatcg 1557781 aaatgatgga tgcttatgac tatgtcgttg aaaacgataa tgtcgaaacg gcttgcgata 1557841 aaatcaaagc aatcgttctt gctgaacatt tgaagcgtga acgcgttgca ccaagatata 1557901 agaaaatgct ggaggttgaa taatcaatgt tagatccgtc aattgattct ttaatgaata 1557961 aattagattc aaaatatacg ctggtgactg tttctgcgag acgtgcccgt gaaatgcaaa 1558021 tcaaaaaaga ccaaatgatt gaacatacga tttcacacaa atatgtaggc aaagctttag 1558081 aagaaattga tgcaggcctg ctttcgtttg aaaaggaaga ccgcgaatag tagcacaagt 1558141 agcaacctat atcatgtagg ttgttatttt tttccgtgcg gttttgtaaa gtgcagaggg 1558201 ggagaattca ttgcttaaca atcgaaatgt gttactttgc gtgagtggag gcatcgctgt 1558261 ttataaagcc tgtgcgttaa cgagcaagct ggttcaggca ggagcaaatg tcaaagtgat 1558321 tatgactgaa tccgcttgcc gattcgtttc accgctgaca tttcaggcat tgagccgcca 1558381 cgaagtctat acagatacat ttaaagaaca aaatccaagc gtcatttctc atattgatgc 1558441 cgcagactgg gccgacttga ttatcgtagc gccggctacg gctaatgtga ttggaaaact 1558501 ggcaaacggc atcgctgatg atatgctgac gacaacattg ttggcagcaa cggctcccgt 1558561 ttggatcgcg ccggcaatga acgttcatat gtatgaccac ccggcagtca aacgaaacat 1558621 ttctgttctt tatcaggacg gttattgttt tattgagcca agtgagggct atttagcatg 1558681 cggttacgta ggaaaaggca gattggaaga gccggaaaac atcgtaaagc tggccgaaaa 1558741 acattttgct gaagaaacat ccgctccttt agaaggcaag catgtggtca ttacagccgg 1558801 cccaacgcgg gaagcgattg atcctgtccg gttttttacc aataaatcga cgggcaaaat 1558861 gggctacgca ctggcggagg ctgctgttca gctcggcgca cgggtaatct taatttctgg 1558921 gcctgtttca cttgatcagc ctaaaggcct tgctgagttt atccctgttc aatcggctgc 1558981 ggatatgcgc gaagctgtgc tctctgtgta tgacgcaagc gatatagtca ttaaaacagc 1559041 tgcggtagcc gattttacgc cgaaaacagt atttgaccat aaaatgaaaa aacaagacgg 1559101 cggcatgacc ttagaactga aaagaacagt cgatattttg aaagaattgg gcgagaaaaa 1559161 gaaagagcag attttggtcg gatttgccgc cgaaacacaa gacattgaac actatgcacg 1559221 taaaaagctc gccgctaaaa accttgattt gattgtggca aatgatgtga aagcaaatgg 1559281 ggccggtttt ggtgctgata cgaatatcgt gacaatcttt ttcaaagacg ggcataaacg 1559341 cgaactcccg attatgtcta agctcgatgt ttcttttgaa atccttcagg agatcgcagc 1559401 cctctcaaaa caaaccggag agcgctcatg aattttgcag aagtcatcgt tgatgtcagc 1559461 accaaaaata tagacaggcc ttttgattat aaaatcccag accatctgaa gggcatgatc 1559521 aaaacgggga tgcgggtcat tgttccgttt ggcccccgta agattcaagg gtttgtgaca 1559581 gcagtcaaag aagcatctga cctatcggga aaatctgtca aggaagtaga ggatttatta 1559641 gatcttacac ctgttctgac agaggagctt atgattctgt catcatggct gtcagacaaa 1559701 acgctgtctt ttaaaataac ggcgcttcaa gcaatgctgc ctgccgcctt aaaggcgaaa 1559761 tatgaaaaag aattaaaaat tgcacacgga gccgatcttc cgccgcaagt ggaacggctg 1559821 ttttctgaaa caaagacgct gctgtattca gatatacccg atcatgagac gctgaaactg 1559881 attcaaaggc atgttcaaaa aggggacatt gacgtgacgt ataaagtcgc gcaaaaaacc 1559941 aataaaaaaa tggtcaggca tattcaggca aatgcgagta aagaagagct tgctaagcag 1560001 gctgagggat tgtcccgcca agcagcaaaa cagcaggcga ttcttcactt tctcatctct 1560061 gagccggaag gtgtgaaaat tcctgcggcg gaattgtgca aaaaaacgga cacgagctct 1560121 gcaaccatca aaacccttat ccaaaaaggg cttttgaagg aaagctatga agaggtttac 1560181 agagatccct atcaggacaa aatgttcaaa aaaacagagc ccctgccgct gacagacgaa 1560241 cagagggctg ccttcgagcc catacgcgag acattggaca gcgatgagca taaagtgttc 1560301 ctccttcacg gcgtgacagg aagcggaaaa accgaaattt atctgcaatc aattgaaaaa 1560361 gtactggcga aaggaaaaga agccatcgtc ctcgtaccgg aaatatcgct gacgccgcaa 1560421 atggtcaacc gcttcaaggg ccgcttcggc tcccaggtgg cagtcatgca cagcggttta 1560481 tccacaggag aaaaatatga cgagtggcgt aaaatccacc ggaaggaagt acggcttgtc 1560541 gtcggtgcca gatccgccat ttttgctccg tttgaaaatc tcggaatgat aatcatcgat 1560601 gaagagcacg agtcttccta taaacaggaa gaaatgccgc gctatcatgc gaaagaggtg 1560661 gcaatcaagc gggctgagca tcacagctgc ccggttgtat tagggagtgc tacgccgaca 1560721 ttagaatcat atgctagagc gcaaaagggc gtatacgagc ttctttcact gaagcaccgt 1560781 gttaaccatc gggtgatgcc cgaggtttcg cttgtcgata tgagagagga gcttagaaac 1560841 ggcaatcgct cgatgttttc agttgaattg atggaaaagc ttgaagaaac gattgccaag 1560901 ggtgagcagg cggtgctgtt tttaaataag aggggctact cttcctttgt gatgtgcagg 1560961 gattgcggct atgtcccgca atgcccgcac tgcgacattt ccatgacgta tcatcgttac 1561021 ggccaaaggc tgaaatgcca ttattgcgga catgaagagc ctgttccgca cacttgtcct 1561081 gaatgcgcaa gcgagcatat ccgctttttc ggaacgggaa cacagcgagt ggaggaagag 1561141 ctgacaaaag tgctgccaag tgcgagagtg attcggatgg atgttgacac gacatcacgg 1561201 aaaggcgccc atgaaaaatt actgtcagct ttcggagaag gaaaagcgga tattcttctc 1561261 ggaacgcaaa tgatcgcgaa agggcttgat tttccgaatg tcacgcttgt cggagtgtta 1561321 agtgctgata caacacttca tattcctgat ttcagatcgg ctgaaaaaac atttcagctg 1561381 ttaacgcaag tcagcggccg ggcaggcagg catgaaaagc ccggccatgt catcattcaa 1561441 acgtatacac cgtctcatta cagtatccag ctgacgaaaa cacacgatta tgaaacgttc 1561501 tatcagcatg aaatggcgca caggagagag caatcctatc cgccatacta ctatttggct 1561561 cttgtgactg tttctcatga ggaagtggcg aaagcagcgg ttacagctga aaaaatcgct 1561621 cattttttga aagcaaactg cggagctgac acgaaaattc tcggaccaag cgcgtcgccg 1561681 atagccagga tcaaagatag atatcgctat caatgcgtga taaaatacaa acaggaaacc 1561741 cagttatccg ctttattgaa gaagatactg gaacattata aacgcgaaat tgaacaaaaa 1561801 catgtaatga tttcaattga tatgaatcct tatatgatga tgtaagatct cacgtcttgg 1561861 agggtaacaa attggcagta aaaaaggtcg tcacacatcc tgcggaggtt ttggaaacac 1561921 ctgcggaaac cgtgactgtt tttgataaaa agctaaaaaa actgcttgat gatatgtacg 1561981 acaccatgct tgaaatggat ggtgtcggac tggcagcgcc gcaaatcggc attttaaaaa 1562041 gagcggccgt cgtagaaatc ggggatgaca gagggagaat tgatctcgtt aatcctgaaa 1562101 ttttagaaaa aagcggcgag caaaccggaa ttgaaggatg cttgagcttt cctaacgtct 1562161 atggtgatgt cacacgtgcc gattatgtca aagtgcgtgc gtttaaccgt cagggaaaac 1562221 cgttcattct ggaagcgcga ggctttttag caagagccgt gcagcatgaa atggaccact 1562281 tagacggtgt gctgtttaca tctaaaataa gtaaatacta tacagaagat gaactagcgg 1562341 atatggaagg atgatttgat gacgagaatc gtatttatgg gaacgccgga tttttcagtt 1562401 cctgttttaa gaaccctgat agaggacgga tatgaagtag tgggggtcgt cacacagccg 1562461 gaccgtccga agggcagaaa aaaagtactg acacctcctc cggtaaagga agaggcattg 1562521 cgccacggca tcccggttct tcagccggaa aaagtcagat tgacagaaga aattgaaaaa 1562581 gtgctggcat taaagcctga cctgattgta acggcggcat tcggacaaat tttgcctaaa 1562641 gagcttctcg acagtccaaa atacggctgc attaacgttc acgcatccct tttgccggaa 1562701 ctgcgcggcg gtgctccgat ccattattcc attctgcagg gaaagaagaa aaccgggatt 1562761 accattatgt atatggtaga aaaattggat gcgggcgata tgatctcaaa agtggaagtg 1562821 gacattgaag aaaccgacaa tgtcggaaca ctgcacgata aattaagcgt tgctggcgcg 1562881 aagctattgt ctgaaacggt tccaaacgtt attgccggca gcatatcacc tgaaaagcag 1562941 gatgaagaga aagcgacgta cgcgcctaac attaaaagag agcaagagct gctcgactgg 1563001 tccagaacgg gcgaagagct ttacaaccag atccgcggct taaatccatg gcctgttgct 1563061 tatacgactc taaacggaca aaacttgaaa atatgggcgt cgaaaaaaat agcggcacca 1563121 acaacagctg agcccggcac agtcgttgca gttgaaaagg aaggaattat cgttgccaca 1563181 ggtaacgaga cggctctgtt attaaccgaa ctccagccgg caggcaaaaa acgaatgaaa 1563241 ggcgaagact ttgtgcgagg cgctcatgtt gaagccggtg atgtgttagg agtaaacaat 1563301 gaaaaaaact agtgttcgtg acatcgccct tgaggcgctg atcaaattag aacaaaacca 1563361 ggcatacagc aacctgctgc tgaaatcggt cattaaatca aatgaactga gtgatcagaa 1563421 cagagggctt ttgactgaac ttgtctatgg tacattacaa aataagatcg cgcttgatta 1563481 tatgcttaaa ccgtttatca ataagcctca aaaggtaaag ccgtgggtga ttcagcttct 1563541 tcgcctatcc ttatatcaaa tggagtattt ggagaagatt ccagacaggg cagccattca 1563601 tgaagcggtt gagattgcta aaatccgcgg acacaaaggc attgcttcat ttgtcaacgg 1563661 cgtgctccgt tctattcagc gcgaaggtgt tccatccttt gacgcgatcg aagatcctgt 1563721 ccgccggctg gcgacagaaa caagccatcc ggaatggctt gtgaaagagt gggcggatgc 1563781 gtatggattt gaagctgcgg aaaagatttg ccgcatccat ctcattccgc cgaaacagac 1563841 gctgcgtgtc aatcaaatga aagcagacag agctgagctg cttgaccaaa tggctgctga 1563901 gggaatcgaa gttgaaaaag gcgacctcgc tgaagatgct gtgaagctct taaagggaac 1563961 aattgccgga actcatttct tccaaaacgg cgaagtttct atccaggatg agagctccat 1564021 gctcgtcgcc cgcgcccttg atcctaagtc agatgaaaca gtgcttgacg cgtgtgcggc 1564081 gcctggcgga aagtcggctc atatcgcaga attaatgaag aacaagggga gcgttacgtc 1564141 gcttgatctt cacaaacata aagtgaagct gatcaaagaa gcggcagatc ggcttggcct 1564201 gacaatcatt catgcggaaa caatggatgc tagaaaagcg ggggaaacgt ttgaaaacga 1564261 acagtttgac cgaatattgg tcgatgcccc gtgctcaggt ttcggtgtta tcagaagaaa 1564321 gccggacatg aaatacacga aaaaacctga cgacagcgcc cgtctagctg aaatccagct 1564381 gtcgatcttg agggaaatcg caccattagt aaaaaaaggt ggcactcttg tctacagtac 1564441 gtgtacaatg gaccggacag aaaatgatga agtaatacat gcgtttatac aagaacatcc 1564501 tgattttgaa cccgatttgt ctcttgaaaa gcggctgcct gaaaaggtga gaccctttgt 1564561 tcgggatgga aggcttcaaa tccttcctca ttatttcgga acagatggtt tctttatttg 1564621 cagcatgaga aagaagggat aagcaatggc agaacttaat aaaacaaaag taagaaaaga 1564681 attgcggaca gagcgtccgt ctatttattc ttttgaatta gatgaaatca aacaatggct 1564741 gacagacaat ggagagaaac cgttccgtgc agcccagatc tttgaatggc tatatgaaaa 1564801 acgcgtatct tcttttgaag atatgacaaa cctctcaaag gatctgcgtg agaaattaaa 1564861 cactcgcttt gtgttaacaa cgctgaaaac ggctgttaaa caaacctctc aagacggtac 1564921 gatgaagttt ttgtttgagc ttcatgacgg ttataccatc gaaaccgttt taatgagaca 1564981 cgagtatggc aattctgtat gtgtaacgac acaagtcggc tgccgtattg gctgcacatt 1565041 ctgcgcgtca acgcttggag gcttaaaacg aaaccttgaa gcaggggaaa ttgtcgctca 1565101 agtagtcaaa gtgcaaaaag ctcttgatga aacggatgaa cgcgtcagct ctgtcgtgat 1565161 catgggaatc ggcgaacctt ttgataactt taacgaaatg ctcgctttct tgaaaatcat 1565221 taaccatgac aagggcctga atatcggtgc tcgccatatt acggtctcta cgagtggaat 1565281 catcccgaaa atttacgaat ttgctgatca gcaaatgcag attaactttg caatttctct 1565341 gcacgcgccg aacacagaaa tcagaagccg tttgatgccg attaacagag catataaact 1565401 gcctgatcta atggaagccg ttaaatatta tattaataaa acaggacgcc gtatcagctt 1565461 tgaatacggg ctgttcggag gcgtaaacga ccaggtggaa cacgccgaag agcttgccga 1565521 cttgctggaa ggagtcaaat gccacgtgaa cttgattccg gtaaactacg tgcctgaacg 1565581 ggactatgtg cgcacaccgc gtgatcagat ttttgctttt gaaaaaacgc tgaaatcccg 1565641 cggagtaaat gtcacaatcc gaagagagca aggacatgac attgacgcag cctgcggtca 1565701 gcttcgcgcg aaggagcgtc aagacgagac gaggtgatga gggttgttaa cagccttaaa 1565761 aacagataca ggaaaaatcc gccagcataa tgaagatgat gcggggatat tcaaggggaa 1565821 agatgaattt atattagcgg ttgtcgctga tggcatgggc ggccatcttg ctggagatgt 1565881 tgcgagcaag atggctgtga aagccatggg ggagaaatgg aatgaagcag agacgattcc 1565941 aactgcgccc tcggaatgtg aaaaatggct cattgaacag attctatcgg taaacagcaa 1566001 aatatacgat cacgctcaag cccacgaaga atgccaaggc atggggacga cgattgtatg 1566061 tgcacttttt acggggaaaa cggtttctgt tgcccatatc ggagacagca gatgctattt 1566121 gcttcaggac gatgatttcg ttcaagtgac agaagaccat tcgcttgtaa atgaactggt 1566181 tcgcactgga gagatttcca gagaagacgc tgaacatcat ccgcgaaaaa atgtgttgac 1566241 gaaggcgctt ggaacagacc agttagtcag tattgacacc cgttcctttg atatagaacc 1566301 cggagacaaa ctgcttctat gttctgacgg actgacaaat aaagtggaag gcactgagtt 1566361 aaaagacatc ctgcaaagcg attcagctcc tcaggaaaaa gtaaacctgc ttgtggacaa 1566421 agccaatcag aatggcggag aagacaacat tacagcagtt ttgcttgagc ttgctttaca 1566481 agttgaagag ggtgaagatc agtgctaatc ggcaagcgga tcagcgggcg ttaccaaatt 1566541 ctccgcgtca taggcggcgg gggaatggcc aacgtgtatt tagctgagga tatcattcta 1566601 gaccgtgaag tcgcaattaa aatcctgcgg tttgactatg caaatgacaa tgaatttatc 1566661 agacgtttcc gcagagaagc ccaatccgca tcaagcctcg atcacccgaa tattgtcagc 1566721 atttatgatt tgggcgagga agatgatatt tattatattg tcatggaata cgttgaaggc 1566781 atgacgctta aagaatacat aacagcaaat gggccgcttc accctaaaga agcgctgaac 1566841 atcatggagc aaattgtctc agccatcgct catgcccatc aaaaccagat tgttcacaga 1566901 gacatcaagc cgcataacat tttgattgat catatgggaa atatcaaagt aacggatttt 1566961 ggaattgcga cggcactaag ttcgaccaca atcacccata ccaattcagt tctgggctcg 1567021 gtccattact tatcacctga acaggcccgg ggcggcttag ccacaaaaaa atcggatatt 1567081 tatgcgcttg gaatcgttct atttgagctt ttaaccggcc gtattccgtt tgatggagag 1567141 tcagcagtca gcatcgcctt gaagcatctt caagcggaaa ctccttcggc aaaaaggtgg 1567201 aatccatcgg tcccccaaag cgttgaaaac atcatactca aggcaactgc caaagatcct 1567261 tttcatcgct acgaaacggc tgaagacatg gaagcagaca taaaaacagc ttttgatgcc 1567321 gacagactca atgaaaagag atttacgatt caagaagatg aagaaatgac aaaagcgata 1567381 cctatcatta aagatgaaga acttgctaaa gctgctggcg aaaaagaagc tgaagtgaca 1567441 accgcacaag aaaacaaaac aaagaagaac ggcaaaagaa aaaagtggcc gtgggttttg 1567501 ctcacgatat gcctcgtttt tatcacagct ggaattcttg ctgtcactgt ttttccgtcg 1567561 cttttcatgc ctaaggatgt caaaatacct gatgtctccg gaatggaata cgaaaaagcc 1567621 gcagggctct tggaaaaaga aggtttacag gttgattccg aggtgttgga aatctcagat 1567681 gaaaaaattg aagagggcct gatggtaaaa acggatccta aagcggatac cacagtcaaa 1567741 gaaggcgcca cggtcaccct ttataagagc accggaaaag caaaaacgga gatcggtgat 1567801 gtgacaggcc aaacggtcga ccaagcaaaa aaagcgttga aggaccaagg gtttaatcat 1567861 gtaacagtaa atgaagtgaa tgacgagaaa aatgcgggca ctgtcattga ccaaaatcct 1567921 tcagcaggga ctgagctggt cccgagtgaa gatcaagtca aacttacagt cagtatcgga 1567981 cccgaagaca ttacgcttag agacttgaaa acctacagta aagaagcagc gtctggatat 1568041 ctggaagaca acggattgaa gcttgtagaa aaagaagcat actcagatga tgttccagaa 1568101 ggacaggttg tcaaacaaaa accagcagca ggtacggcag taaagccggg aaacgaagtt 1568161 gaagtgacat tctctctcgg accagagaaa aaacctgcga aaacagtgaa agaaaaggtc 1568221 aagatcccct acgaaccaga aaatgaaggg gacgagcttc aagtgcaaat cgcggttgac 1568281 gatgcggatc acagcatctc tgacacttac gaagaattta agataaaaga gccgactgaa 1568341 cgaacgatcg aactaaagat tgaaccaggc caaaaagggt actatcaagt aatggtaaac 1568401 aataaagttg tcagctacaa aaccattgag tatccgaaag atgaataaca aggagggaaa 1568461 atatgcctga gggcaaaatt attaaggcgc taagcggctt ttactatgta ctggatgaat 1568521 cagaggattc agataaagta atacaatgca gaggaagagg cattttcaga aaaaacaaaa 1568581 ttacccctct tgtcggtgat tacgttgtgt atcaagctga aaatgacaaa gaaggatatc 1568641 taatggaaat taaagaaaga accaacgagc ttatcaggcc gccaatttgc aacgttgatc 1568701 aagcggtcct tgttttctca gcggttcagc cttctttcag cacggcattg ctcgaccgct 1568761 tcctggttct cgttgaggcc aatgatattc agccgattat atgcattact aaaatggatc 1568821 tgattgaaga tcaagataca gaagatacga tacaagccta tgcagaagac tatcggaata 1568881 ttggttatga cgtatacctt acctcctcta aggaccaaga tagtttagcg gacatcatcc 1568941 cgcattttca ggataaaaca acggtatttg ccggtcagtc cggtgttggg aaatcctcgc 1569001 ttctcaacgc gatcagtccg gagctcggat taagaacaaa cgagatttcc gagcatttgg 1569061 gccgcgggaa acacacaacc cgccacgtgg agctgattca cacgtccgga ggtttggttg 1569121 cagatacacc gggattcagc tcgcttgaat ttacagacat tgaggaagaa gagctgggct 1569181 ataccttccc tgatatcaga gaaaaaagct cttcatgcaa atttagaggc tgtttacatc 1569241 tgaaagagcc gaaatgtgcg gtgaaacaag ctgttgaaga cggggaatta aagcagtatc 1569301 gctatgacca ttatgttgaa tttatgacgg agattaaaga cagaaagccg aggtattagc 1569361 ataatgataa aggttgcacc atctattctt tccgctgatt ttgccgcttt aggcaatgag 1569421 attaaagatg tagaaaaagg cggagccgat tgtattcata ttgatgttat ggacggccat 1569481 tttgtcccga atatcacaat cggtccgctg attgtagaag cggtccggcc ggtaacggat 1569541 ctgccgcttg atgtccattt aatgatagaa gagccggatc gttatatccc ggcttttgcg 1569601 aaagcaggcg cagatatcct gtctgtgcat gctgaggcat gtccgcacct gcaccgtacc 1569661 atccagctca ttaaagagca aggagtgaag gccggagtag ttctaaaccc gcatacccct 1569721 gtacaagtca tcgaacatgt tttcgacgat cttgatcttg ttcttttaat gacggtgaac 1569781 ccgggcttcg gcgggcagaa atttattcat tcagtccttc ctaaaataaa agaggttaag 1569841 cgaatggcgg atgaaaaagg aaaaaaagat ctgttaattg aagtagacgg cggcgtcaac 1569901 aaagaaaccg ctccgctcgt cattgaagcg ggcgcaaatt tactcgttgc cggttcagct 1569961 gtttatggcc agtctgaccg caaaaaagca atttctgaaa tcagaggaag taaataagca 1570021 gctttagaaa agagctgggc atacaatagc ctaagctctt tttcctgtat gcagagaaag 1570081 gaatcagaga tgaaaacaat taatatcgtt gcgggaggcc cgaaaaatct cattcccgat 1570141 ctaaccggct atacggatga acacacgctt tggatcggtg ttgacaaagg caccgtcact 1570201 ctcttagatg ccgggatcat tcctgttgaa gccttcggag attttgacag cataacggag 1570261 caagaacgcc ggcgaataga aaaagccgct cccgcccttc atgtgtatca agcagaaaaa 1570321 gatcaaacag atttagacct cgcccttgat tgggcgctgg aaaagcagcc ggatattatt 1570381 cagattttcg gcattacagg cggcagagct gatcattttt taggaaacat tcagcttctg 1570441 tataaaggtg taaaaacgaa cataaaaatt aggctgatag acaaacaaaa tcatattcaa 1570501 atgttccctc ctggtgaata tgatattgag aaggatgaaa ataagcgata tatctccttc 1570561 ataccgtttt ccgaagacat acatgagctg accctgaccg gttttaaata tcctctaaat 1570621 aattgtcata ttacgctcgg ttcaacacta tgtattagta acgaactcat tcattcacga 1570681 ggtacttttt cgtttgcaaa aggcatatta ataatgataa gaagcacgga ttaagcatgt 1570741 gctttcattc aattgctgaa aacaatgaac aaggcggtta cgggacgtta taggagggga 1570801 caaaaatgaa attttacacc attaaattgc cgaagttttt aggaggaatt gtccgggcga 1570861 tgctgggctc atttagaaaa gattaatgcc caggggttca aagccctctt tcaccacata 1570921 aaaacgcctg ccacatatcg gggcaggcgt tcattttgtt atacacgctc aactttaccg 1570981 gatttcaaag ctcgagcaga tacatatact tttttaggtt ttccgttcac aaggatacga 1571041 accttttgaa gattcgcgcc ccaagtgcgc ttagaagcgt tcattgcgtg agaacggtta 1571101 ttcccagctg ttgttttttt acctgtgata acgcatttac gtgccatttg tttccctcct 1571161 cacttgcaca aaacatctac tttttaacat tcatataatc ttagatgctt tcgatatgga 1571221 tactttaaat aatttaccac agctaaaaaa cgtttgcaac tattgtttca tcatctttca 1571281 agaaaattca cttgacatct tgcggaaaca gcagcgctat agtatatgta gaggtacggc 1571341 cagcgattat tgcctggtct tttcataatg gaaaccatat agtagaatag ctgtaactct 1571401 atgcattcga aggaggaact agtgtgtcca ttgaattaag aacgaagtac ggacagattg 1571461 atatatctaa tgaagtcatc gcgatggttg caggaggcgc ggcggttgac tgttacggca 1571521 ttgtcggcat ggcctctaaa aaccagatta aagacggact gactgaaatc cttcggaaag 1571581 agaatttcag caggggtgtc caagttcgcc aagaaggaga acagatacat atcgacatgt 1571641 atatcattgt cagctacggc acgaaaattt ctgaagtggc acataatgtc caaacaaaag 1571701 taaagtacac agtaaatcaa accatcggac tggcagtgga ttctgtcaat atttatgtcc 1571761 aaggcgtacg agtgacgaac ccgtagttag gaggagtagg attgtctatc agaacattag 1571821 acggcagaac ctttgccgag atgattcttg cgggagcgca gaatctgtct caaaacgcca 1571881 gtgcagttga tgcactgaac gtgttcccgg tgccggacgg tgatacggga acaaatatga 1571941 acctgtcgat gacttccgga gcaagagaag ttgaacaaat ggatacggat gatatcggga 1572001 aggtgggctc cgcgttatct aaagggctgc tcatgggagc acgcggaaat tcaggagtta 1572061 tcctatccca attgttccgc ggatttagca aaaacattga aacgaaaaaa gaaattaatg 1572121 cacttgagtt tgccgctgcg ctgcaagcag gtgtagacat ggcgtataaa gctgtcatga 1572181 aacctgtaga gggcaccatt ttaacagttg caaaagacgc tgcaaaaaaa gcaatgatct 1572241 tagcagaaaa agaaaccgat atcactgcgc tgatgactgc agtgacagaa gaagcagagg 1572301 cgtctttaaa ccgcacccct gaattgctac ctgtcctaaa ggaagtagga gttgtcgata 1572361 gcgggggcaa aggcctgctc tgtgtgtatg aaggtttcct tgcttcatta aaaggtgaaa 1572421 ctgtacctca gaaagcagtt cttccgtcac ttgacgacat ggtcagcgca gagcatcaca 1572481 agagcgcgca aagcatgatg aataccgaag atattgaatt tggattctgt accgaagtga 1572541 tggttaggct tgatcagaca aaaagagagt tcgacgaagg cacgttcagg caagacctca 1572601 gccagttcgg agattctctg cttgtgattg cggatgaatc gctggcgaag gttcatattc 1572661 atgctgaaga gccgggaaac gtgttaaact acgcccagca ttacggtgaa ttgatcaaaa 1572721 taaaaataga aaatatgaga gaacagcata cctctatcat cagtcaagaa agcaaacctg 1572781 cagacaacga aacaccgccg gcaaaacagc cgtatggcat tgtgactgta gcgatgggag 1572841 aaggaattgc agacctattt aaaagcattg gcgcttctgt tgtgattgaa ggcggccaga 1572901 ccatgaaccc aagcactgag gatattgttg atgccgtgaa gtctgtaaat gcagatacgg 1572961 tatttatcct gcctaacaac tccaacatta tcatggctgc taaccaagcg gccagcgtag 1573021 tggatgaaca ggtttttgtc attcctgcta aaacggttcc gcaagggatg tcagctctgc 1573081 tggcttttaa cccggatcaa gaagctgaag cgaacgaggc caatatgcta agcgccattc 1573141 agcaagtaaa aagcggacag gtgacgttct cagtcagaga tactcatatt gacggtaaag 1573201 acattaaaaa aggcgacttt atgggcattc tgaatggaac gattatcggc acttctgaaa 1573261 atcagctgtc agccgcgaaa atgctgctgt cagaaatgat cggagaagat gatgaaatcg 1573321 tgaccattct atatggtgag gatgcgtctc aggaagaagc tgagcagctt gaagcgtttc 1573381 tcagtgaaaa gtacgaggag attgaggttg agatccacaa tgggaaacag cctctgtatt 1573441 cgtatatagt ttcagcagaa tagaagggca atttgccctt ctattcttat gtctgctttt 1573501 aagtgcggca gcgctgtaac gcgcccgctt gccattttat atctgatcaa ttagtctaga 1573561 agcaaagcgc taataagctc tggttcataa ggaggaatag catgaaatac agaagcgttt 1573621 ttgatattat cggcccggtt atgatcggtc cgtccagctc tcatacagcg ggagctgcta 1573681 gaatcgggag agtggccaga agtttatttg gcagagagcc tgagcgcatc attgtatctt 1573741 tttacggctc gtttgcggaa acgtataagg gccacggcac agatgtcgcg attatcggcg 1573801 gattgcttga ttttgataca ttcgatgaac ggattaaaac cgctatacaa attgcagaag 1573861 ctaaaggaat tgatatagag tttcgggtag aagacgcagt cccggtccac ccgaacacag 1573921 caaaaatcac catttctgat gaaaagggtg agctggaact gacgggtatt tcgattggcg 1573981 gaggaaagat tgaaatcaca gaattgaatg gttttgagct ccggctgtca ggaaatcatc 1574041 cggccatatt agttgttcat aatgacaagt ttggcacaat tgccggtgtt gccaatgttc 1574101 tggcgaaatt ttcaatcaac gtaggacata tggaagtagc ccggaaagat atcggccagc 1574161 ttgcgctgat gacaatagag gtcgatcaaa atattgacga ccacattctc gacgagctgt 1574221 cgaagctgcc gaatattatt caagtgacaa agattgctga ctagcgaaaa gggtcaggag 1574281 gagccagtta tgtttcgtaa tgtaaaagaa ttaattgaga ttactaaaga aaaacaaata 1574341 ttgatctctg atgtgatgat agctcaagag atggaagtaa cagaaaaaac aaaagaggac 1574401 atttttcagc agatggatca taacctgtct gttatggaag cggcggttca gaaaggactc 1574461 gagggagtta cgagccaaac gggcttaaca ggcggagatg ccgttaaatt gcaggcctat 1574521 attcgatcag gaaaaagcct gtctggcccg ctgattttag atgctgtatc gaaagccgtt 1574581 gcaacaaatg aagtaaatgc agccatggga accatctgtg cgacaccgac tgcaggttct 1574641 gccggtgtgg tgcccggtac gttatttgct gtaaaagaaa agctgaatcc aacaagagaa 1574701 caaatgatcc gctttttgtt tacagccggg gctttcggat ttgtcgtggc caataacgca 1574761 agcatttccg gcgccgccgg aggatgtcag gcagaggttg gatcagcttc aggcatggcg 1574821 gctgcggcta ttgttgaaat ggcaggagga acacccgaac aaagcgcgga agccatggcc 1574881 attacattaa aaaatatgct aggcctcgtg tgcgaccctg ttgcagggct tgttgaggtg 1574941 ccttgcgtga aacggaatgc gatgggcgcg tcaaatgcga tgattgctgc tgatatggca 1575001 ttggcgggca ttacaagccg tattccatgt gatgaggtta tcgatgccat gtataaaata 1575061 ggccaaacga tgccaactgc acttagagaa acaggccagg gcggtttagc ggcaacaccg 1575121 acaggaagag aattagagaa aaaaattttc ggaggagcgc taggttcacg tgaaacaaca 1575181 tcagcaaact agtatagcta acattaaggg tattgggccg gaaacagaaa aaacattgaa 1575241 tgaactcggt atttatgaca tttctgatct tctgaattat ttcccttatc gctatgatga 1575301 ctacgagctg agggatttag aagaagtaaa gcatgatgaa agagtcacag tcgaagggaa 1575361 ggttcattca gagccttctc ttacctatta cggaaaaaaa cgaaacaggc tgacattcag 1575421 gcttctggtc ggccactatt taatcacagc cgtatgtttt aaccggcctt atttgaagaa 1575481 gaagctttcg ctcggctctg tggtgacggt ttcaggtaaa tgggacaagc accgccaaac 1575541 catctctgtt caggagttga aaaacgggcc gcatcaagaa gacaaaagca ttgaaccagt 1575601 gtattctgtg aaagaaaatg ttaccgtcaa aatgatgagg cgctttattc agcaggcgct 1575661 gacccaatat gcagactcac ttcctgatcc tcttccggaa aagctaagaa aaagctataa 1575721 actgcctgac tattatcaag cgttaaaagc aatgcaccag cctgaaacaa gggaagcatt 1575781 aaagcttgcc agacggcggt ttgtttatga agaatttttg ttgtttcagt tgaaaatgca 1575841 ggcgttccga aaggcggaaa gagagcagac acaagggata cggcagcgtt tttcaaacga 1575901 agaactcatg agatttatca aaagcctccc gtttcccctc acaaacgccc agtcacgcgt 1575961 tcttcgcgaa ataacagcag acatgtcttc tccatacaga atgaaccgtc ttcttcaagg 1576021 ggacgttgga tcaggaaaaa cggcagtcgc cgccattgca ctgtatgccg cgatcctatc 1576081 cggataccaa ggagcgctca tggtgccgac agaaattctg gccgagcagc atgctgattc 1576141 gctcgtttcg ctatttgaaa aatgggacgt cagcgttgct cttttgacaa gctctgttaa 1576201 aggaaagcgg cgaaaagaac tgcttgagcg tcttgcggcg ggtgagattg atattcttgt 1576261 aggaacccat gctttaatcc aagacgaggt ggagtttaag gcgttgagtc tcgttattac 1576321 tgatgaacag cacagatttg gagttgagca gcgcaaaaag cttcggaaca aagggcagga 1576381 tcccgatgtt ctctttatga cagccactcc aatcccaaga acattagcga tcacagtatt 1576441 cggtgaaatg gatgtatctg tcattgatga gatgccggct ggacgaaagc gaattgaaac 1576501 ctattgggta aaacatgaca tgcttgatcg tattttggca tttgtcgaaa aagaattaaa 1576561 gcaaggcagg caggcttata tcatctgtcc gctgattgaa gaatcagata agcttgatgt 1576621 gcaaaacgcc attgacgtgt acaatatgct ttctgatatt tttcggggaa aatggaatgt 1576681 cggccttatg catggaaagc tgcattccga tgaaaaagat caggtcatga gagaattcag 1576741 cgcaaatcac tgtcaaattc tcgtatcaac cactgttgtg gaggttggcg taaatgttcc 1576801 gaatgcaaca attatggtga tttatgacgc cgaccgtttc ggactatcac agcttcacca 1576861 gctgcgcggc cgtgttggac ggggtgagca tcaatctttc tgtattctga tggctgatcc 1576921 aaaatcagaa acagggaaag aacggatgag gatcatgtcg gagaccaatg acggtttcga 1576981 gctgtctgaa aaggatctgg aactgagagg tcccggtgat ttcttcggga aaaaacaaag 1577041 cggaatgccg gaatttaaag tggcggacat ggttcatgat tacagagcgc ttgaaacggc 1577101 aaggcaggat gctgcgaatc ttgtggcttc tgacgcgttc tggaaggagc cggaatacgc 1577161 tgtgttaaga gatgaattgc tgaagagcgg agtaatggac ggggaaaaat taagctgagt 1577221 atcagaagtt tttggtgttc agccagaaac aatcgttgca ttccaatcta tgaaattata 1577281 tactactatt agtacctagt cttaattgtc cggatggtgt ttagatatga gaagaaataa 1577341 gagagaacgc caggaattac ttcagcagac gattcaagca acccccttta ttacagatga 1577401 agaactagcg ggtaaattcg gggtgagcat ccagacgata cgtttggacc gcttagagct 1577461 ttccatacct gaactgagag aaagaattaa gaacgtggca gagaaaacac ttgaggacga 1577521 agtgaagtcc ctgtcacttg atgaagttat cggagaaatt attgaccttg agctggatga 1577581 tcaggcgata tccattttag aaataaaaca ggagcacgtg ttcagccgga atcagattgc 1577641 gagaggacac catttatttg cacaggcgaa ttctttggcc gttgcagtca ttgatgacga 1577701 gctggcgctg actgcaagtg cagacatccg ctttacaaga caggtaaagc agggtgaacg 1577761 tgtcgtagca aaagcgaaag tgacggctgt cgaaaaagaa aaaggaagaa cggttgtcga 1577821 agtgaacagc tacgttggcg aagaaattgt tttttctgga cgctttgaca tgtatcgttc 1577881 aaaacattca taaaggtgga gcatgcatga gaatagctgt agatgcaatg ggaggagacc 1577941 acgctcccaa agctgttatt gacggagtta taaaaggtat agaggcattt gatgatctcc 1578001 atatcacact tgtcggtgac aaaacaacga tagaatcaca tttaacaact acatcagatc 1578061 gcatcacggt gctgcacgca gatgaagtga ttgagcctac ggatgaaccg gtccgtgccg 1578121 tgcgaagaaa aaagaactca tctatggttc ttatggcgca ggaggttgcg gaaaacagag 1578181 ctgacgcctg catttcagcg ggaaataccg gtgcattaat gacagccggt ctctttattg 1578241 tcgggagaat taaaggaatt gaccgtccgg cgcttgctcc gacacttccg actgtttcgg 1578301 gagacggatt tcttctcctt gatgtcggcg ccaatgtcga tgccaaaccg gagcacctcg 1578361 ttcaatatgc catcatgggt tctgtttatt ctcagcaagt gcgcggtgtc acttcaccga 1578421 gagtcggact tttaaatgtc ggaacagaag ataaaaaagg aaacgaactg acgaagcaga 1578481 cgtttcaaat tttaaaagaa acagcaaaca tcaattttat cggaaacgtg gaagcgcgag 1578541 accttttaga tgatgtggcg gatgttgtag taacagacgg ctttaccggg aatgttacac 1578601 tcaaaacgct ggaaggctct gcgttgtcaa tttttaaaat gatgagagac gtaatgacgt 1578661 ctactttgac atccaagctt gcagcagctg tgctgaaacc aaaattgaaa gaaatgaaaa 1578721 tgaaaatgga gtattcgaat tatggcggag caagtctttt tggcttaaaa gcgcctgtga 1578781 tcaaggcgca cggctcttca gattcaaatg ctgtattcca tgcgattcgg caagcaagag 1578841 agatggtcag ccaaaatgtg gctgcgctca ttcaggaaga agtgaaagaa gaaaaaacag 1578901 atgagtagtc tggaggtttt tacatcatga gtaagattgc atttttattc ccgggtcagg 1578961 gatcacaatt tatcggcatg ggaaaagagc tttatgagca ggtgcctgct gcaaagcgtc 1579021 tgtttgatga agccgatgaa acgttggaaa caaaactcag ctcgcttatt tttgaggggg 1579081 atgctgaaga attaacactt acatacaatg cgcagcctgc tttgcttacg acaagcatcg 1579141 ctgttcttga gaaatttaaa gaatctggca ttacacctga tttcacagca ggacacagcc 1579201 ttggtgaata ttctgcactg gttgcggctg gcgctctgtc tttcaaagat gctgtttata 1579261 ctgtcagaaa gcgcggagag tttatgaatg aagcggtgcc ggctggcgaa ggagcaatgg 1579321 ctgcgattct cggcatggat gctgaagcat taaagcaagt aaccgataaa gtcacagagg 1579381 aaggcaacct tgtacagctt gcgaatctca actgtcctgg ccaaatcgtc atttccggaa 1579441 cagctaaagg ggttgagctt gcatctgaac tggcaaaaga gaacggcgca aaacgcgcaa 1579501 ttccgcttga agtaagcggt ccgttccatt ctgaactgat gaaaccggct gctgaaaagc 1579561 tgaaagaggt attggacgcc tgtgacataa aagacgctga cgttccggtc atctcaaatg 1579621 tttctgctga cgtgatgact gaaaaagcag atatcaaaga aaaacttatt gagcagcttt 1579681 actctccggt tcgttttgag gaaagcatta acaagctgat cgcagagggt gttacgactt 1579741 ttattgaaat cggtcccgga aaagtgcttt caggccttgt gaaaaaagtg aatagacggt 1579801 taaaaacaat tgctgtatca gatccggaaa cgatcgagct ggcaattcaa acgcttaagg 1579861 aggagaatga taatgcttaa tgataaaacg gctattgtca ctggcgcatc ccgcggaatc 1579921 ggccgctcaa tcgcccttga tctggcaaaa agcggagcaa atgttgtcgt gaactactcc 1579981 ggcaatgaag cgaaagcaaa tgaagtggta gatgaaatca aatcaatggg cagaaaagca 1580041 attgctgtaa aagcggatgt atcaaatccc gaagatgtac aaaacatgat aaaagaaaca 1580101 ttgtctgttt tttctacgat tgacattctg gttaataatg cgggaattac aagagacaat 1580161 ctcatcatga gaatgaaaga agacgaatgg gatgacgtca ttaacattaa cctgaagggt 1580221 gttttcaact gcacaaaagc tgttacaaga caaatgatga aacagcgttc aggccgcatt 1580281 attaacgtat cgtctatcgt cggcgtcagc ggaaaccctg gacaagccaa ctacgtggct 1580341 gcaaaagccg gcgtcatcgg tttaaccaaa tcttctgcta aagagctcgc cagccgaaat 1580401 attacggtaa acgcaatagc gccaggattt atctcaactg atatgacaga taaacttgca 1580461 aaagacgttc aagacgaaat gctgaaacaa attccgctcg cgcgctttgg tgaacctagc 1580521 gatgtcagca gtgttgtcac gttcctagct tcagagggag ctcgttatat gacaggccaa 1580581 acgcttcata ttgacggcgg aatggtgatg taagtttttt ctcgaaaatt tcatcgtagt 1580641 ttctctagtt ttttaaaaac gaatccacta taatacttga ggggaggtga attgctatgg 1580701 cagacacatt agagcgtgta acgaaaatca tcgtagatcg ccttggcgtt gatgaagcag 1580761 acgtcaaact tgaagcttct ttcaaggaag acttaggtgc tgattcccta gatgtagttg 1580821 agcttgttat ggaacttgaa gacgagtttg atatggagat ttctgacgaa gatgctgaaa 1580881 agattgcaac agtcggcgac gctgtgaact acatacaaaa ccagcaataa gctgatgcta 1580941 aaagtcccgc cgaaacgcgg ggctttagcc ctttattcgt gcagttatta cagcatgccg 1581001 cttttacgcg cgctgtatcc ggtttagtca gagaagcgcg gtgaacctga tgtgcctatg 1581061 gaggttacta tgtcaaaaca ctcacattat aaagataaaa aaaagttcta taaaaaagta 1581121 gaacaattta aagagtttca agaacggatt tcggttcact ttcaaaatga aaagcttttg 1581181 tatcaagcat ttacacattc atcttatgtg aatgagcatc ggaaaaagcc gtatgaagat 1581241 aatgaaaggc ttgaattttt aggtgacgct gttttggaac tgacgatctc cagattctta 1581301 tttgccaaat acccggctat gagtgaagga gatttgacga aattgagagc cgcaattgtt 1581361 tgcgaaccgt ctctcgtttc attggctcac gagctgtcat tcggcgatct tgtcctgttg 1581421 ggtaaaggcg aggaaatgac aggcggaaga aagcgtcctg ctctattggc ggatgttttt 1581481 gaggcattta tcggagcctt gtaccttgac caaggattag agccggtcga aagtttctta 1581541 aaagtttatg tgttccctaa aattaacgat ggtgcttttt ctcatgtgat ggatttcaaa 1581601 agccagctgc aggaatacgt gcagcgggac ggcaaaggct ctctggagta taaaatctcc 1581661 aacgaaaaag gacctgcgca caaccgtgaa tttgaagcca tcgtatctct aaaaggtgaa 1581721 ccactcggag tcggaaacgg ccgttcaaag aaagaagccg aacagcacgc tgctcaggaa 1581781 gctttagcta aattgcaaaa acaccatacg aaacaataaa atccccctta tgactcaggg 1581841 ggatttcagt atgtatgccg tcttatttga ccaatgttta tgatagaatt gaaatactta 1581901 ttacataagg aggatcgcta tgttcctcaa acgtttagac gttataggat ttaaatcatt 1581961 tgcagaacgg atttccgtag acttcgttaa aggcgtgaca gcagttgtcg ggccgaacgg 1582021 aagcggaaaa agcaacatca cggatgccat tcgctgggtt ctcggcgaac aatcggcacg 1582081 ctctcttcgc ggcggaaaaa tggaagacat catttttgct gggagtgatt caagaaagcg 1582141 attaaatcta gctgaagtta cgcttactct tgataatgat gatcatttct tgccaattga 1582201 cttccacgag gtgagtgtca caagacgtgt gtacagatca ggtgagagtg agtttctgat 1582261 taacaatcag ccatgccgct tgaaagatat tattgattta tttatggact ctgggcttgg 1582321 taaagaagca ttttctatta tcagccaagg gaaagtggaa gagatcctga gcagcaaagc 1582381 ggaggatcgc cgcagtatct ttgaagaagc ggccggggtg cttaaatata aaacgagaaa 1582441 gaaaaaagca gaaaataaac tgtttgagac acaggacaat ctaaatcggg tagaagatat 1582501 attacatgag cttgaaggac aggttgaacc tcttaaaatt caagcttcaa tagcgaaaga 1582561 ctaccttgag aaaaagaaag agctggagca tgttgaaatt gcgctgactg cctatgatat 1582621 cgaagagctg catggtaaat ggtcgactct taaagagaaa gtgcagatgg caaaagaaga 1582681 agagcttgct gaatcgtctg ctatttctgc gaaagaagca aagattgagg atacaaggga 1582741 caaaatacaa gcgcttgatg agtcagtaga tgagctccag caagttttac tggtaactag 1582801 tgaagagctg gaaaagcttg aaggccgtaa agaagtcctg aaagaacgaa agaaaaacgc 1582861 tgtgcaaaac caagaacagc ttgaagaagc catcgttcag ttccagcaaa aagaaacggt 1582921 tctgaaagaa gagctttcga agcaggaagc tgtcttcgaa acgcttcagg ctgaggtgaa 1582981 gcagttaagg gcgcaagtaa aagaaaaaca gcaggctctc agtcttcaca atgaaaatgt 1583041 cgaagagaaa atcgagcagc tgaaaagtga ttattttgag ctgttaaaca gccaggcttc 1583101 gatacgcaac gaactccagc ttcttgatga ccagatgtcc caatccgctg tcacattgca 1583161 gagacttgcg gacaacaatg aaaagcacct gcaggaacgg catgatattt ctgcgcgtaa 1583221 agccgcatgt gaaacggaat ttgcccgaat tgagcaggag attcacagtc aagtcggtgc 1583281 atatcgtgat atgcagacaa aatatgagca gaaaaagcgc caatacgaaa aaaatgaatc 1583341 cgctctgtat caggcatacc aatacgttca gcaagcgaga tcaaaaaagg acatgcttga 1583401 gacgatgcag ggagatttct ccggctttta tcaaggtgtt aaagaagtgc tgaaagcgaa 1583461 agagcgcctt ggcggaattc gcggagcggt tcttgagctg atttctacag aacagaagta 1583521 tgaaacggcc attgaaatag cgctcggcgc ttctgctcaa cacgtcgtga ccgacgatga 1583581 acaatctgcc cgcaaagcga ttcaatattt aaagcagaat tccttcggcc gggcgacgtt 1583641 tctgcctctt tctgttatta gagaccgcca gcttcaaagc cgtgacgcgg aaacagccgc 1583701 ccggcattca tcatttctcg gggttgccag tgaacttgtc acatttgatc ctgcgtatcg 1583761 aagcgtcatc cagaatcttc ttggaaccgt tctgatcaca gaggacttaa agggtgcaaa 1583821 cgagcttgcg aagcttctcg ggcaccggta ccgcatcgta acccttgagg gagatgttgt 1583881 gaaccccggt ggttcaatga cgggcggcgc ggttaaaaag aaaaataact ccctccttgg 1583941 aagaagccgg gagctagaag atgtgacgaa acggctcgct gaaatggaag agaaaacggc 1584001 actgcttgaa caagaggtca aaacccttaa gcactccatt caggatatgg agaaaaaact 1584061 ggctgactta agagaaaccg gggaaggctt aaggttaaag cagcaggatg tgaaaggcca 1584121 gctgtacgaa cttcaagttg ccgagaaaaa tatcaatacc catttagagc tctatgatca 1584181 agaaaaatct gctctgtcag aaagcgatga agagagaaaa gtgcgcaaac gcaagcttga 1584241 agaagagctc tctgccgtat ctgaaaagat gaaacagctt gaagaggaca tagacagact 1584301 gacaaaacaa aaacaaacgc aatcctcaac gaaagagtct ctctccaacg agctgactga 1584361 gctgaagatc gcagcggcca aaaaagagca ggcttgcaag ggggaagagg acaaccttgc 1584421 cagattaaag aaagagctca ctgaaacaga gcttgcgtta aaagaagcaa aagaagactt 1584481 aagcttctta acgtcagaga tgtcatctag caccagcggc gaagaaaagc tggaagaagc 1584541 agcaaaacat aaattgaatg acaaaacgaa aacgatcgaa ctgattgcat taaggcgcga 1584601 tcagcgcatc aagcttcagc atgggcttga tacgtatgag cgtgagctga aagaaatgaa 1584661 acgcctgtat aaacaaaaaa caacgctctt aaaagacgaa gaagtcaaac ttggacgaat 1584721 ggaagtcgag cttgataatt tactccaata cttacgggag gaatacagct tgtcctttga 1584781 gggggcaaaa gagaaatatc agcttgaaac tgatccagag gaagccagaa agcgcgtgaa 1584841 gctgattaaa ctcgcaattg aagagctggg taccgtgaac ctcggaagca tagatgagtt 1584901 tgagagggtc aacgaacggt acaagtttct gtcggaacaa aaagaagatt taacagaagc 1584961 gaaaaatacc ttgttccaag tgattgaaga aatggatgaa gaaatgacga agcgctttaa 1585021 cgacacattc gtccaaatcc gctcacactt tgatcaagtt ttccgctcct tattcggagg 1585081 agggcgagct gaactgaggc tcaccgatcc taacgatctg cttcattcag gagtcgagat 1585141 tatcgctcag ccgccgggga aaaagctgca aaacttaaac ctcctgtcag gcggagagcg 1585201 tgcgcttact gctatagcgc tcttattctc aatcctaaag gttcgtccag tgccgttttg 1585261 cgtccttgac gaagtagagg ctgcgctcga cgaagcgaat gtgttccgat ttgcgcagta 1585321 tttaaaaaaa tacagcagcg atactcagtt tattgtgatt acccacagaa aaggaacgat 1585381 ggaggaagcg gatgtgcttt atggcgtaac catgcaggaa tccggtgttt ccaaggtaat 1585441 ttcagttaag ctggaagaaa caaaagaatt cgttcagtaa cgaggaaaga ggttaaaaga 1585501 tgagcttttt taaaaaatta aaagagaaaa tcacaaaaca gacagattcc gtatctgaaa 1585561 agtttaagga tggccttgaa aaaacaagaa actcctttca aaacaaagtg aatgatcttg 1585621 tatcccgtta ccgtaaagtg gatgaggatt tcttcgaaga gcttgaagag gttcttatca 1585681 gcgcggatgt cggttttaca accgttatgg aattaataga tgagctgaaa aaagaagtca 1585741 aacgcagaaa tattcaagat ccaaaggaag tccagtcagt gatttctgag aaactggtcg 1585801 agatttataa cagcggagat gagcaaattt cagaactgaa catccaggat gggcgtttaa 1585861 acgtaatcct tctggtaggt gtaaacggcg tcgggaaaac aacaacgatc ggaaagcttg 1585921 ctcataaaat gaaacaagaa ggaaaatctg ttgtacttgc cgccggagac acttttagag 1585981 cgggagccat tgaacagctg gaagtatggg gagagcgtac aggagtgcct gtcattaagc 1586041 agacggcagg aagcgatccg gcggctgtca tctacgatgc tgttcatgct gcgaaagcaa 1586101 gaaatgccga tgtattaatt tgtgatacgg cagggcgtct ccaaaacaaa gtaaatctca 1586161 tgaaagagct tgaaaaagta aaacgtgtta tcgaaagaga agttcctgaa gctccgcatg 1586221 aggtgctgct tgcccttgat gccacgaccg gccaaaatgc aatggctcag gcaaaagaat 1586281 tctctaaagc aacaaatgtt accggcattg ctttaacgaa gcttgacggt acggcaaaag 1586341 gcggtatcgt ccttgcgatt cgcaacgagc ttcacatccc ggttaaacta gtcggtttag 1586401 gagaaaaagt tgatgacctt caggaatttg atccagaatc ctatgtgtac ggactctttt 1586461 cagatttagt ggaaaaagcc gacgattaag aaaaaggccc caacatcttg gggccttttt 1586521 cttttttatc ttcttacttg ataggcgaaa tgataaaggc tgttatcagt ggataccagt 1586581 cttgactcac cagaaaaaac tctgaatggg atgatgtcat agtaatgaac ggaaacagat 1586641 gtgtaatacg tatagtaacc agcagctggc cccaaataca ttggaacctc aaatgttccg 1586701 tttgcatcag tcgttcctga agcagtttgt gttgtgtttc cgaccttcgt gtccgcttca 1586761 aatcttacgg gcgcgtttgg cactggctgt ccgttttggt cgagtaattt gccgcttact 1586821 gtaatattgt acttgactcg ccaatattga ccttgtccgt aattgatttt accgtatacc 1586881 cctccatctg tgctgatatt tgtgattgag gccttataag gtgcctcagc agcgtctgct 1586941 tgctgtgccg ggaaacctat tgtaaacagg gctgccagac ataacataaa caataaaccg 1587001 atttttttca taaaaatcct ccttaaaata gggttcatat acaatatcgg aataaattgg 1587061 atgatattta gcgtattttg gaaaagttaa tcgccgcttt gacaagataa aaacttgaca 1587121 gtgtcattaa aaccgtgtaa actaagttat cgtaaaggga tttgacttaa caaaggggag 1587181 agctcaaatg tcactcgaaa agacaacgag aatgaattat ctgtttgatt tttatcagtc 1587241 gttgttgacg tcaaaacaga agagctatat gtcgctttat tatttggacg atttctccct 1587301 aggcgaaata gccgaagaat atgaggtttc aagacaagct gtttatgata acatcaaacg 1587361 aacagaagca atgcttgaac aatatgaaga aaagctgctc cttttgaaaa agtttcagga 1587421 gcgtaaagag atgtttaata agctgaagga gcttgcttcc ggttcaaaag aagaggaaga 1587481 aattacagct ctgattgaag cgcttgagaa attagattag gaggcggcaa actatggcat 1587541 ttgaaggatt agccgaccga ctgcagcaga cgatttctaa aatccgcgga aaagggaaag 1587601 tcagcgaaca agatgtaaaa gagatgatgc gtgaggtccg tcttgcgctg cttgaggctg 1587661 acgttaactt taaagtagtc aaggattttg tcaaaaaagt aagtgaacgc gctgtaggcc 1587721 aagacgtcat gaaaagtctg acgcccggcc agcaggtcat taaagttgtt caagaggaac 1587781 tgactgagct gatgggcggc gaagagagca aaatcgccgt cgcaaaaagg ccgccgactg 1587841 ttattatgat ggtcggtctc caaggtgccg gtaaaacgac aacaagcggt aagcttgcga 1587901 atctgctgcg caaaaagcat aatcgcaaac cgatgctggt tgctgccgat atttaccgcc 1587961 cagccgcaat taagcagctg gaaacactcg gcaaacagct tgatatgcct gttttctctc 1588021 ttggcgatca ggtcagtcct gtagaaatag ctaaacaggc tattgagaaa gccaaggaag 1588081 aacattatga ctacgtcatt ttggatacgg cagggcgctt gcatatcgac catgaactga 1588141 tggatgaact gaccaacgtc aaagaaatcg cgaatccgga agaaattttc ctggttgtcg 1588201 attcaatgac cggtcaggac gctgtgaatg ttgccaaaag ctttaatgaa cagctcggtt 1588261 taaccggtgt tgtgttgact aagctggatg gagacacacg cggcggggct gcgctttcta 1588321 ttcgcgctgt cacaaacacg ccaattaagt ttgcaggttt gggcgaaaag cttgatgcgt 1588381 tagagccgtt ccatcctgaa cgcatggcat caaggattct cggcatgggc gacgtgctga 1588441 cattgattga aaaagcacag gccagcgttg atgaagacaa agccaaagag ctggaacaaa 1588501 aaatgagaac gatgagcttc acattggacg attttctgga gcagctcggg caagtcagaa 1588561 acatggggcc gcttgatgag cttctgcaaa tgatgccggg tgcaggtaaa atgaagggcc 1588621 tgaaaaacat ccaagttgat gaaaaacagc tgaatcatgt ggaagcaatc atcaaatcaa 1588681 tgactgttct tgaaaaagaa cagccggata ttatcaatgc cagccggcgg aagcggattg 1588741 caaaaggaag cgggacatcc gtacaggaag tcaaccgtct gcttaagcag tttgatgaaa 1588801 tgaaaaaaat gatgaagcag atgacaaaca tgtcaaaagg caagaaaaaa gggtttaagc 1588861 taccttttat gtaatcggtt atacatgata aaaccgttgt taagaaaaaa cactttacaa 1588921 acacttttat cattgttaat atactatctt gttgaaatat tttcggaggt gctagtaaaa 1588981 tggcagtaaa aattcgttta aaacgtatgg gagcaaaaaa atctcctttc tatcgtattg 1589041 ttgtagcaga ttctcgttca ccacgtgacg gccgtttcat cgaaacagtc ggaacttaca 1589101 acccggttgc aaaaccagcg gaagtaaaaa ttgacgaaga gcttgctctt aaatggcttc 1589161 aaactggagc gaaaccatct gatacagttc gcaacttgtt ctctagccaa ggaatcatgg 1589221 aaaaattcca caacgctaaa caaggcaagt aatgactgat caacacttgg aagatttgat 1589281 tgtccacatt gtgacgccgc ttgttgatca tccagatgac attcgcgtca taagagaaga 1589341 aaccgatcaa aagattgcgc tgcgcttatc tgtccataag tcagataccg gtaaagttat 1589401 cggaaagcaa ggccggactg caaaagcgat tcgaacagct gtatttgcag ctggcgtaca 1589461 gtcttctaag aaagttcaat ttgaaatatt tgactaaaag ggagagggcc ggcacctccc 1589521 ctttttttac acgcaaaaaa agggtaaact gatagaagct taggcaaaat agaaaagcct 1589581 ggacgagtaa aagttttaaa agcggggagc ttggtgcgat gcaaattatt caccgtgtag 1589641 ccgttatgca agtcttaacc gagcgcagta aagaaaagct tttagcttct tttgctgaga 1589701 agaaacaaat gcttgaacga gaatgcagcc agctctattt tcagcttaga aaacatgaga 1589761 aagaacagca aaaccctaat atgattgaac aatttaaaaa ggcaatagaa aagcgaaaag 1589821 atgatataaa aatcattgat tttcaaattg ctcaagtaca tacattgccg cttggcagtg 1589881 agttgaaaga aaaggaagtc gatgcgctgc tgacgattga agccggggat gactggcatg 1589941 agaaaacagc agcgaacacc atcgtcataa aagacggaaa agtaattgaa attcgccaga 1590001 ggtgatcata tgacaaagcg atggtttaat gtaggcaaaa tcgtaaatac ccacggaatc 1590061 aaaggcgaag tgcgggtgat ttcaaaaaca gattttgccg aagaacgata caagccggga 1590121 aacacgctgt atttgtttat ggacggccgt aacgaaccag tggaggtaac ggtaaacaca 1590181 catagactgc ataagcaatt tcatctcctg cagtttaaag aaagacaaaa cctaaatgaa 1590241 gtagaagagc tgaaaaacgc aatcattaaa gttcctgaag aagaattagg agagctgaat 1590301 gagggtgaat tttatttcca cgaaattatt gggtgtgaag tatttactga agaaggcgaa 1590361 ctcatcggaa aggtcaaaga aattttgacg cctggagcca atgacgtttg ggtcatcgga 1590421 cgaaaaggaa aaaaagacgc actcattcct tacattgaat cagtggttaa acatatcgat 1590481 gtcagggaaa agaaaattga gattgaactc atggaagggt taatagacga atgaaaatcg 1590541 attttttgac gctgtttccc gaaatgtttg aaggcgtgct cggctcatcg attcttcaaa 1590601 aagcccagga aaaagatgcg gtgcagtttc aagtcgtaaa tttccgagag tactctgata 1590661 acaagcacaa tactgttgat gattatcctt atggcggcgg ggcaggcatg gttctcaagc 1590721 cccagcctgt ttttgacgcg gtcgaggacc tgacatcaaa ggcagccgct gctccgcgta 1590781 ttatcctcgt atgcccgcaa ggtgagcgtt ttacccaaaa aaaagccgaa caattagcta 1590841 aggaagagca tttgctgttc atttgcggcc actatgaagg ctatgatgaa cgcattcgcg 1590901 agcacttggt aacggatgaa atatcaattg gcgactttgt tctgacgggc ggtgagctcc 1590961 ctgcaatgat gatcgcagac agtgtggtca gactgcttcc gggtgtactg ggtaaagagg 1591021 cttcccatat tgaggattcc ttcagcaccg gacttttaga gcacccgcat tatacaagac 1591081 cggcagatta caaaggttta aaagtgcctg aaacactctt gtcaggaaac catgcaaaaa 1591141 ttgaagaatg gcggaataaa gaatcgatca gaaggaccta cctaagacgt ccggatctgt 1591201 tgaaagacca cccgcttaca gagcagcaaa gaaagtggat ttctgaatgg gaaaaagaat 1591261 agattttatt gcataggcta tgaaattgtg ataagatact acttgtggct taagcgggct 1591321 tatccgctgc aagcttgaaa acgatgttcc gctgtgccgg tttttgtggc caagagcatc 1591381 tgttggaagg agttgaaaac gatgcaaaaa ctaattgaag atatcacaaa agaacagctt 1591441 cgtactgatc ttcctgcgtt ccgtcctggt gacactttac gtgtacacgt taaagttgtt 1591501 gagggtaacc gtgagcgtat ccagatcttt gaaggtgttg tgattaagcg tcgtggtggt 1591561 ggaatcagcg aaacgttcac agttcgtaag atttcttacg gtgttggcgt tgaacgtact 1591621 ttcccagtac acacaccaaa aatcgcgaaa atcgaagttg tacgttacgg taaagtacgc 1591681 cgtgctaaac tttactacct gcgtgaactt cgcggaaaag cggctcgtat taaagagatc 1591741 agacgataat gataacgaac gaaaagagct tgttacctgt aacaagctct ttttttatac 1591801 agaatttgaa aatgccggac aggcatcgta aaatacataa aggacaacaa tgaatcatgc 1591861 atactgaaga taaaggcggt gttcgtgtca catgacaatt caatggttcc cgggccatat 1591921 ggcaaaagca agaagggaag taaccgaaaa attaaaatta atcgatatcg tatatgaatt 1591981 ggtagatgcc agaattccaa tgtcatcaag aaacccaatg attgaagata ttctaaaaaa 1592041 caagccgcga attatgctgt taaacaaggc tgacaaagca gatgcggcag ttacacagca 1592101 gtggaaagag cactttgaga accaggggat ccgctctctg tctattaatt ctgtaaatgg 1592161 acaagggtta aatcaaattg tgcctgcatc aaaagagatc ctccaagaaa aatttgaccg 1592221 gatgcgtgcg aaaggtgtga agccgagagc gattcgcgct ttgattatcg gcattccaaa 1592281 cgtcggaaaa tcaacgctca tcaaccggct tgcaaagaaa aacatagcaa aaacgggaga 1592341 cagacctggt attacgactt ctcaacagtg ggtcaaagtt gggaaagaat tagagctatt 1592401 agatacaccg ggaattttgt ggcctaaatt tgaggatgag cttgtcggtt tgagactggc 1592461 agtcaccggg gctattaaag actcgattat caatttgcag gacgtggccg tgtttggtct 1592521 tcgttttctc gaagaacatt acccagaacg gcttaaagag cgttatggcc ttgatgagat 1592581 cccagaggac attgccgagc tgtttgatgc aataggtgaa aagcggggct gtctcatgag 1592641 cggtgggctc atcaactacg ataagacgac tgaagtcatc attcgcgata ttcgcactga 1592701 aaagttcggc aggctgtcat ttgaacagcc gacgatgtaa aggcgcgcag aaatgcgggt 1592761 ctttattttt tcttggctga accgatacat acagtaaggg agaagagaaa gtgaatacat 1592821 taaccgtaaa ggacattaaa gaccgtttgc aggaagtgaa ggatgcacaa gacccattta 1592881 ttgcccaatg cgaaaacgac ccgagaaaaa gcgttcaaac gcttgtagag caatggctta 1592941 aaaagcaagc gaaagaaaaa gcgctgaaag aacaatgggt gaatatgact tcctatgaaa 1593001 ggctggcaag aaacaaagga tttcgcttga ttgcaggtgt tgacgaggtc ggccgggggc 1593061 cattggcagg accagttgtc gccagcgcag tcatccttcc agaggaatgt gaaatacttg 1593121 ggctgacaga ctccaaaaag ctttcagaga aaaaacgcga ggaatattac gagcttatta 1593181 tgaaggaagc actggcggtc gggataggaa ttgtagaagc tactgtgatt gatgagatca 1593241 atatatatga agcttcaaaa atggcaatgg tgaaagcgat acaggatttg tcggatacac 1593301 ctgattattt gcttgttgac gcaatgacac ttccgctcga cacggctcag gcgtcaatta 1593361 taaaaggcga tgccaaaagc gtgtctattg cggcaggtgc gtgtatcgca aaagtgacga 1593421 gggaccgaat gatgagcgct tatgccgaaa cgtatcccat gtacggcttt gaaaaaaata 1593481 aaggctatgg gacaaaagaa catttggaag ctctcgctgc atacggccca actgaattgc 1593541 accgcaaaac tttcgctcct gttcaatctt tcagataaat caccatggac aaggaggcac 1593601 ctttttaaaa tgaacatacg aaatgatgtg caaaaggcgc tgcagcacct tttcgggcgt 1593661 acagccgtcc cgcaggaaac atcaaaagta aacgaagcgc taaacgggga gaagcgtctc 1593721 ctcttaggaa aagtgcttcg tttactagga gatcagcatg ccctgatcca agtcggcaat 1593781 caaactgttc agggaaaact tgaaactcag cttcgtcctc aggcatacta ttggttttcc 1593841 tacgaaaaaa aaacggcaga gcaaacaggc cgtcttcagg tcgttcaaag ctttgatcaa 1593901 aatcctaaaa ccattcagga tgcagctggc aaacttttaa atgctatttc agtgaagacg 1593961 tcaaacgcag ctctcatgat gacaggagcg atgctgaaaa gcaaaacacc cgtaacagaa 1594021 aatgatatca aaacagctgt ccgctggatg gacacgctgc cttcgcaaga cacaaaaaaa 1594081 gcagttgaaa cggttctctt cgctttaaag cgtgatcttc ccattcactc cgagattttg 1594141 aatggtgttc acgctgtgaa atcgcctgtt ccgttgcatc agcacgtatc ccagctgcta 1594201 caggcaatcg accaaaaccc tcagcagagc caaatgatgt caaagctaaa ggaagcagtc 1594261 acggtgcttt taaatagtga aatcgatgtc catgcagaac ggctgattga taagcttatt 1594321 tctttaaccg acaatacgaa agcaccttct ccgacgaata cagctggaag cagggagctt 1594381 agcacaccag ctggctcccc cggaaaagcc agcctgccga ttgcaaatca cacagcagaa 1594441 cagggaagca tacaagaaga gcctgttaaa acagcagcag acattccaat taaagaagcc 1594501 cgccagctgc tggtgaagct gacggaatct gctgaaaaaa acagtctcca aattgtgaaa 1594561 gaagcagcaa attggattaa agcggctgct tcatcgggtg atagtaagtc acttgcagct 1594621 tcagctgttt tacaggcggc acaagtcaca gatcaggaag ccgaagtctt tttaaaggct 1594681 gttcagcaga cagcacccca tttggcggat aaggcagatg ttctttcttt cttatccaaa 1594741 gtgaaaacgg caatcggcgc aagggacgag gttgcgttca ttaaagcgtt tgaacaagga 1594801 agcgcagtca catctggcga aatgcaatcc atcaagctgg ctctttctgc cttaagagca 1594861 tcgcatgagg tagccgaacc agtcaaacaa gaagccgatc agctttttca taaattaaat 1594921 ggccagcttt tcatgcagca ggaccatcca tcatacagcc aaattgtaat gtcatttccg 1594981 atgttttcga agtcaggggt tcaggacatg actgttctgt ttaaaggaaa gaaagaagcg 1595041 gatggaaagc ttgatccttc ccattgccgc cttttgtttt tgctgcagct tgatacacta 1595101 aaagaaaccg tcgttgattg cttggtacag caaaaagtca tgaccattac aatagagact 1595161 gatttcgagc tgcaggctgc gatcgatccg atggtgcccg cgcttaaaca ggggctaaag 1595221 gaaatggggt acagcctttc aggggtaaac gctaaaaaaa gggttcacac cgaagaaaag 1595281 gcttcaatcg atcaatatat aacaagtatc agtgatcagg aagtggatgt gaaaatatga 1595341 aagagcagac accgatcaga aaagctgttg ctctccatta tgacgaacaa aaagacaagg 1595401 cgccgagagt gattgccaca gggaagggcc atgtagctga caacattata aaagaagcga 1595461 aaaaagcagg ggtcccgatt caagaagatc ggacccttgt cgaattaatg cgccatttga 1595521 cggtagatga tcaaattcct gaagctcttt atgaaacggt agccgagatt ttttcattca 1595581 tttacaaatt ggacgaaagc gtaaaaaaca aaaaatagct aaaatattcc ccatccttct 1595641 ttgaaattta tgtttttaat aaagtaaaag tttgaatgtt tagaaggatt aaaagatttt 1595701 gcatcgaact gtagacaatt cttccagtat tattatagaa tgaaagcgca gtctatttta 1595761 gttttgttac ataagttagg aggatgggaa atgaatatcc atgagtacca gggaaaagaa 1595821 gtcctcagaa aatatggggt atctgttcct gaaggtaaag tggcttttac agcagaagaa 1595881 gcagttgaga gtgcaaagag cttatccagc tcggtttatg tcgtaaaggc tcaaattcat 1595941 gctggcggtc gaggcaaagc tggtggggta aaaatagcaa aatcattaga cgaagtaaaa 1596001 gcgtatgccg aagaactatt agggaagacc ctagttacac atcagacggg tccggacggc 1596061 caagtaataa aacgcttact tattgaagaa ggctgcgata ttaaaaaaga atattacatc 1596121 ggtctagtgc ttgaccgcgc cacttcaaga atcgttttaa tggcttctga agaaggcgga 1596181 acggaaattg aagaggttgc ggagaaaaca ccagaaaaaa tcaaaaaagc tgtcattgat 1596241 ccagctgttg gccttcaagg ctatcaagcc agagaaattg cattcgctat taatattcca 1596301 aaagagctcg tgggaaaagc tgctaaattt atgcttggac tatataaagc gtttgttgag 1596361 aaagactgct caatcgccga aatcaatccg cttgttgtga ctggcgacgg aaatgtgatg 1596421 gcgcttgatg caaaattgaa ttttgacagc aatgcgttgt accgacaaaa ggacattatg 1596481 gaatacagag atttggatga agaagatccg aaagaaattg aagcgtccaa atatgatcta 1596541 agctacattt cccttgatgg aaatatcggc tgtatggtaa acggcgcggg acttgcaatg 1596601 tctacgatgg atattatcaa gcattatgga ggagaaccgg ccaacttcct tgatgtgggc 1596661 ggcggtgcaa ccgcggaaaa agtcacggaa gcatttaaaa tcattctttc tgatcaaaac 1596721 gttaaaggga tttttgtcaa cattttcggc ggcattatga aatgtgatgt catcgcagaa 1596781 ggggttgttg aagcgactag acaagttggt ttgacattgc cgcttgtcgt ccgtcttgaa 1596841 ggcacaaacg tggatctagg gaagaaaatc cttagtgaat caggattaaa cattacatct 1596901 gcggaatcaa tggctgacgg cgcgcagaaa atcgtatcct tagtttaaga aagaatgaaa 1596961 ggcaggggac caaataatga gtgttttcat taataaagat acaagagtta ttgtgcaagg 1597021 gattacaggt tctaccgctt tatttcatac gaagcagatg cttgaatacg gcacaaatat 1597081 cgttggcggt gtaacacctg gaaaaggcgg aacagaagcg gaaggtgttc ctgtatttaa 1597141 tacagtggct gaagcagttc aaacaaccgg cgctaacgcg tctgttatat atgtgcccgc 1597201 accgtttgca gctgatgcga ttatggaagc ggtagatgcg gagcttgatc tcgtgatttg 1597261 tatcacagaa catatcccgg ttttggatat ggtgaaggtc aaacgcttca tggaaggcaa 1597321 gaaaacgaga ctgatagggc cgaactgtcc tggtgtcatt acgcctgaag aatgtaaaat 1597381 cggcattatg cccggataca tccataaaaa gggtcatgta ggcgttgtat cacgttcagg 1597441 aacattaaca tacgaagcgg tgcaccagct ctcagaagcg ggtgtagggc aatctacagc 1597501 tgttggaatc ggcggcgacc ctgtaaatgg aacaaacttt attgacgttt taaaagcgtt 1597561 taacgaagat cctgacacac acgcagtcat catgattggc gaaatcggcg gtacggccga 1597621 agaggaagcg gcagagtggg taaaagccaa catgacaaaa ccggtagtcg gttttattgg 1597681 cggtaaaaca gcacctcctg ggaagcgcat ggggcatgca ggcgccatta tttccggcgg 1597741 gaaagggaca gctgatgaaa aaatcaaaac ccttaatgca tgcggaatcg aagttgcaga 1597801 gacaccttct gtcatgggtg aaaccttaat caaggtgctg aaagagaaga acttgttcga 1597861 aacttgtaaa acgcattaat aaaaaaggga cagccgtcaa ggctgttcct gctttttcta 1597921 acaaaaggag gtcaatctat tggatcaggc cgctgtctgc ctaacgattt gcagaatcaa 1597981 tcaattatta tccccatccc ttctattaaa atggtggaaa gccgatccgt ctatgtcgct 1598041 gacatcaccc gtgttacaaa cggttactcg tgatcaaata aaagcagctg cattaaaaaa 1598101 cgaaatagaa caattttatc caaagctccc gcgtgtactt gctgcttatc gtgagcaagg 1598161 cattaacacc atccctattt cttcaaagca atatcctttc tggcttaaaa gcatttatga 1598221 tccccctgcc gtactgtttg caaaaggtga tatgactctt ctttcgaaag ggagaaaaat 1598281 tggaattgta ggcacaagaa atccaacagc ttatgggaaa caagttgtca atcatcttac 1598341 aaaagagatc tgtcgtaaag gttgggtgat tgtcagcgga ctggcgtctg ggatagacgg 1598401 aatgtcccat gctgcaagta ttaaggcgaa ggggcggaca attggcgtca ttgcaggcgg 1598461 atttcaacac atttatcccc gagaaaacct tcagttagca gatcacatgg ctaaacacca 1598521 tatcctgctg tcagagcacc cacctgaaac taaaccccaa aaatggcatt tccctatgag 1598581 aaaccgtatt atcagcggac taagtgaagg cgttattgtc gttcagggca aagaaaaaag 1598641 cggttcgctg attactgcct atcaagcatt ggaacaaggg agagaggtat ttgccgtacc 1598701 cggttcattg tttgaccctt acgccggagg tcctataaaa ctgatccagc agggggctaa 1598761 agccatatgg tcagcagagg atattttcga ggaacttcct gagagaaacg ttcaatatac 1598821 ggaacccttt tgaattatcg tttgacaaac ggtattgtaa tatttaataa tagtgaggat 1598881 ttaaagttgc atattgtttt ctatttaatt aatgacgttc atgataaaga atgaaatgtt 1598941 gaaagccaaa taaagacagc tgcaaaaata aaattgaaat atcttgaaaa gagagagaac 1599001 acctcttgag ggggatgaaa atgtctgatt atctagtcat cgtggaatcg cccgctaagg 1599061 cgaaaacgat tgaacgttac ttaggtaaaa aatataaagt aaaagcatca atgggacatg 1599121 tccgggatct tccaaaaagt caaatgggag ttgacataga acagaatttt gaaccgaaat 1599181 atattaccat tcgaggtaaa ggcccggtat taaaagagct gaaaacggct gcgaaaaaag 1599241 ccaaaaaagt gtatctcgca gctgaccccg acagagaagg ggaagcgatt gcatggcatt 1599301 tggcacacag tcttgattta gatctcaact cagactgccg tgtggtgttt aacgaaatta 1599361 caaaagacgc tattaaggaa tcgtttaagc atccccgcat gatcaatatg gatttagtgg 1599421 atgcacagca agcgagacgt attttagaca ggcttgtcgg atataaaatc agtccaatct 1599481 tatggaaaaa agtcaaaaaa gggcttagcg caggacgcgt gcaatccgtt gccctccgtt 1599541 tgattattga ccgtgaaaaa gagattaacg actttaagcc tgaggaatat tggacaattg 1599601 acggtacgtt cttaaaaggt caagaaacct ttgaagcgag ctttttcggg aaaaacggca 1599661 aaaaacttcc tttaaatagt gaagctgatg taaaagagat tctttctcag ctcaaaggga 1599721 atcaatatac agttgaaaaa gtaaccaaaa aggaacgcaa acgtaatcct gctttgcctt 1599781 ttaccacttc taccctgcag caggaagcgg ctcgcaagct caatttcaga gcgaagaaaa 1599841 cgatgatgat tgcacagcaa ttatatgaag gaattgattt aggaagagaa ggaacggttg 1599901 gtctgatcac gtatatgaga acggattcaa cccgtatttc aaatacggct gttgatgaag 1599961 cagctgcatt tattgatcag acatatggaa aagagttcct aggcggaaaa cggaagcctg 1600021 cgaaaaagaa tgaaaatgcc caggatgccc acgaagcaat tcggccgaca tcagttctta 1600081 gaaaaccaag tgaattaaaa gcagtcctcg gcagagacca aatgagactg tataaattaa 1600141 tttgggagcg ttttgttgcc agccaaatgg caccggctgt tctcgataca atgagtgtcg 1600201 acctgacaaa caacggtttg acatttcgtg caaatggaag taaagtcaag ttttccgggt 1600261 ttatgaaggt gtatgttgaa ggaaaagacg atcaaatgga agaaaaagac cggatgctgc 1600321 ctgacttaca agaaggcgac acggtattat caaaagatat agaacctgag cagcatttta 1600381 cccagccgcc tccgcgatat actgaggccc ggcttgttaa aacccttgaa gaacgcggta 1600441 tcggccgtcc atccacatat gctccgacac ttgatactat tcagcggcgc ggctacgtgg 1600501 cattggataa taaacgtttc gttccgactg aattaggtca gatcgttctt gacttgatca 1600561 tggagttttt ccctgagatc attaacgttg agtttacagc taaaatggag agagatcttg 1600621 atcatgttga agaaggaaat accgaatggg tcaagattat cgataatttc tacaccgatt 1600681 ttgaaaaacg cgtcaaaaaa gccgaatcgg aaatgaagga agttgagatt gaaccagagt 1600741 atgctggaga ggattgtgaa ttgtgcagtt ctccaatggt atataaaatg ggacggtacg 1600801 gtaaattctt agcttgctcc aacttccctg actgccggaa cacgaaaccg attgtgaaac 1600861 aaatcggtgt gaagtgcccg agctgcggag aaggaaacat tgttgagcga aaatcgaaaa 1600921 agaaacgggt gttttacggc tgtgaccgtt atccggactg tgaattcgta tcatgggaca 1600981 aaccaattga acgaaaatgc ccgaaatgcg gaaaaatgct cgtcgagaaa aaactcaaaa 1601041 aaggtataca agtccaatgc gtggaatgcg attataagga agaaccacag aagtagcggt 1601101 gagcagggtc ttgctcacct tctttgtgtg ttaaaagaag gccttgaata ataaactagg 1601161 agatgtgaaa gatgaaccaa caaacagtga atgtaatcgg agccggactc gcaggaagtg 1601221 aagcagcatg gcagcttgcc aaacgtggga ttcaagtcaa attgtatgaa atgcggccag 1601281 ttaaacaaac gcctgcgcat catacagata aatttgctga gcttgtctgc agcaactctc 1601341 ttcgctctaa tacacttgct aacgctgtcg gtgtattaaa ggaagaaatg cgtgcgcttg 1601401 attcagccat tatcgctgcg gctgacgaat gttcggtgcc tgccgggggc gctcttgcag 1601461 tagaccgtca tgaatttgcc gcaagtgtga caaatcgggt gaaaaatcat ccaaacgtaa 1601521 ccgttattaa tgaagaagtg actgaaattc ctgaaggccc tactatcatc gcaacgggtc 1601581 cgttaacatc tgaatcgctg tctgcccagc tgaaggagct gactggagag gactatttat 1601641 atttttatga cgcagcggcg ccaattgtag aaaaagacag ccttgatatg gataaagtgt 1601701 acctgaaatc ccgttatgat aaaggtgaag cagcatattt gaactgcccg atgacagaag 1601761 aagagtttga ccgttttcat gaagcattaa catcagcaga aacagtgccg ttaaaagaat 1601821 ttgaaaaaga gattttcttt gaaggctgca tgccgattga agtcatggca aaacggggta 1601881 agaaaacaat gcttttcggt ccgatgaaac cagttggtct agagcatcct gttacaggaa 1601941 aacgccctta tgccgtcgtt cagctcagac aggatgatgc tgcgggaaca ctttataata 1602001 ttgtaggatt ccagacacat ttaaaatggg gagaccaaaa ggaagttctc aagttgattc 1602061 caggacttga aaatgtagaa atcgtcagat atggcgtgat gcatagaaac acatttatta 1602121 actctccaag cctgttaaag ccgacttatc aatttaaaaa ccgcagtgat ctgttctttg 1602181 caggccaaat gacgggagta gaaggatatg tggaatcagc tgcctcagga cttgtagcag 1602241 gcattaatgc ggcgaagctt gtattgggag aagagcttgt gatcttccct caggaaacag 1602301 caattggcag tatggcacat tatattacaa caacaaacca gaagaacttc cagccgatga 1602361 atgcaaactt tgggcttttg aaagaattgc cagttaaaat taaaaataaa aaagaacgaa 1602421 atgaacaata cgcgaaccgt gcgattgaaa caattcaaac aatttcgaaa acaatatagg 1602481 tattgattgc aacctgagcg cgatttgtga taccatttaa aagcccttcc tggggaggta 1602541 ttaggcatgg agaatgttaa gaatttcgta aagttattcg ttgaatattt acaaattgaa 1602601 aaaaattatt cacaatatac tattgtgaat tatgtggatt caattgaaga attcgagact 1602661 ttcctgcgcg ttcaaggtat aaatggattt gaagaagctg catatcaaga tactaggatt 1602721 tttttgacag aagcctatga aaaaggttta tcgagaagaa caataagcaa aaagatatct 1602781 gcattaagaa gcttttataa gtttctgatg cgggaaaagc ttattgaaga aaatccgttt 1602841 cagcttgttc atctgccaaa acaggagaaa cggataccga agtttctata tcaaaaagag 1602901 cttgaggagc tgtttgaagt ttcagatata agccagccgg ccggaatgag ggatcaagcg 1602961 ctgttagagc tgctctatgc cactggaatg agggtcagtg aatgctgttc cataactatt 1603021 aacgacgttg atttatttat ggacactgtg cttgttcacg gtaaaggcaa gaagcagcgc 1603081 tatatcccct ttgggtctta tgcccgcgaa gcgttgaagg tatacatgaa tagcggaaga 1603141 cagtgcttgc tgatgaaggc aaaagaacct catgatctat tattcgtaaa tcaaagaggc 1603201 ggaccgctta cagcccgtgg catcagacat attttaagcg ggcttgttca aaaagcgtca 1603261 agcactttac atatccatcc gcatatgctt cgacatacgt tcgccacgca tctgttaaat 1603321 gaaggagcgg atttgagaag cgttcaagaa ctgctcgggc attccaatct gtcttctaca 1603381 cagatataca cgcacgtttc gaaggaaatg ttgagaaaca catatatgtc tcaccatcca 1603441 agagcattta agaaaaatta aaggaggccc tttatgtcat cttttcatgc gaccacaata 1603501 tttgccgtac agcataaagg acgaagcgct atgtccggag acggccaagt aacatttggt 1603561 caggctgttg tcatgaaaca cacggcacgg aaagtgagaa aactgtttaa cggcaaagtt 1603621 cttgctggtt ttgcgggatc tgttgcagac gctttcactt tattcgaaaa gtttgaagct 1603681 aagcttgaag aatataacgg caacttaaaa cgggcggctg ttgagcttgc aaaggaatgg 1603741 cgcagtgata aagtgctaag aaagctcgaa gccatgctga ttgttatgaa tcaggatact 1603801 ttgcttctcg tatcgggaac aggcgaggtg atcgaaccag atgacggcat tctcgcgatt 1603861 ggatcaggag gcaattacgc tttggcagcg ggaagagcac tgaaaaagca tgccggggaa 1603921 agcatgtctg caagtgagat tgccagagcc gcgttagaaa cagcaggcga aatttgtgtt 1603981 tacacgaacg atcaaatcat actggaagag cttgaataga aaggacttga ggcgcatgga 1604041 aaaaaaaccg ttaactccta gacagattgt agatcggtta gaccaatata ttgtcggtca 1604101 gcaaaatgcg aaaaaagctg tcgccgtggc attaagaaac cgctatagaa gaagtcttct 1604161 ggatgaaaag ctgaaggacg aggtcgttcc gaaaaacatt ttaatgatgg gtcctaccgg 1604221 cgtcgggaaa actgaaattg ccagacgaat cgctaagctt tcaggtgcgc catttatcaa 1604281 aattgaagct actaaattta ccgaagtcgg ctatgtaggc agagatgttg aatcaatggt 1604341 cagagatctt gtggagactt ctgttcggct tataaaagaa gagaaaatga atgaagtaaa 1604401 ggaacaggca gaagaaaatg caaacaaacg cattgttcgt ctgttagttc ctgggaagaa 1604461 aaaacaatct ggtgttaaaa atccgtttga aatgtttttt ggaggcagcc agccgaatgg 1604521 tgaagatgag gcggagagcc aggaagaagc aaacatcgaa gaaaaaagaa aacgaatggc 1604581 gcatcagctg gctttaggag agctcgaaga ctactatgta acagtagaag tcgaagaaca 1604641 gcagccttct atgtttgaca tgctgcaggg ctcgggtatg gagcagatgg gtatgaacat 1604701 gcaggatgcg ctgagcggat taatgccaaa gaaaaagaag cggcgcaaaa tgacagtcag 1604761 agaagccaga aaagtcctga cgaatgaaga agcaagcaaa ctcatcgata tggatgaagt 1604821 cggccaggaa gctgttcaga gagcagaaga gagcgggatt atctttatcg atgagattga 1604881 taaaatcgca aagaacggcg gtgcatcttc ttctgccgat gtttcaagag aaggtgttca 1604941 gcgggatatc cttccgattg ttgaaggttc taccgttgtc acaaaatatg gttctgtaaa 1605001 aacagaccat gtattattta ttgcagcagg agcgtttcat atggccaaac cgtctgattt 1605061 gattcctgag ctgcaggggc gtttcccgat tcgtgtagaa ctgaacaaac tcacggtaga 1605121 cgacttcgtg agaattttgg ttgagccgga taatgcgctg ctgaaacaat atcaggcatt 1605181 attgcagaca gaaggtatat ctcttgaatt ttctgacgaa gctattcata agattgctga 1605241 agttgcttat catgtgaacc aggacacaga taatatcggt gcgagacgcc ttcatacaat 1605301 acttgaacgc ctattagaag atttgtcgtt tgaagctcca gatgtaacga tggagaaaat 1605361 aacgattaca ccacagtatg tcgaagaaaa gctcggaacg atagccaaaa acaaagattt 1605421 aagtcaattt atattgtgaa aaatttaata tgaggaatgt ttaggaggat tatttatcat 1605481 ggctttatta caaaaaacaa gaattattaa ctccatgctg caagctgcgg cagggaaacc 1605541 ggtaaacttc aaggaaatgg cggagacgct gcgggatgta attgattcca atattttcgt 1605601 tgtaagccgc agagggaaac tccttgggta ttcaattaac cagcaaattg aaaatgatcg 1605661 tatgaaaaaa atgcttgagg atcgtcaatt ccctgaagaa tatacgaaaa atctgtttaa 1605721 tgtccctgaa acatcttcta acttggatat taatagtgaa tatactgctt tccctgttga 1605781 gaacagagac ctgtttcaag ctggtttaac aacaattgtg ccgatcatcg gaggcgggga 1605841 aagattagga acacttattc tttcgcgttt acaagatcaa ttcaatgacg atgacttaat 1605901 tctagctgaa tacggcgcaa cagttgtcgg aatggaaatc ctaagagaaa aagcagaaga 1605961 aattgaagag gaagcaagaa gcaaagctgt cgtacaaatg gctatcagct cgctttctta 1606021 cagtgagctt gaagcaattg agcacatttt tgaggagctt gacggaaatg aaggtcttct 1606081 tgttgcaagt aaaattgctg accgtgtcgg cattacccgt tctgttattg tgaacgcact 1606141 cagaaagctg gagagcgccg gtgttatcga gtctagatca ttaggaatga aaggtactta 1606201 tatcaaggta ctaaacaaca aattcctaat tgaattagaa aatctaaaat ctcattaatc 1606261 acaaaaagaa ccctttttga gggttctttt tttatttcaa ataaaggaaa tcaataagct 1606321 ttatttcctg ggttgaaagt ctttctatgt aataatttta ataaattttg catttttctt 1606381 caaaaagttt caaaaatgcc gaaaagaaag gagaaaaaac agaaattctg ctattttcag 1606441 gcttatatca aggcgagaaa tgtagttcta acaatctagg actttatacc tagttgcaaa 1606501 atagataatt gtgaggacat ttttttacac gaacttcata gactttatgc ctgttatttc 1606561 ttacaataag catatagttt tacaattctc gacaaggata ttgagggtga aaaaaactga 1606621 aatggaggta agtggatttg agcttatttt ctggaacgat acaaaatctt gaaaatgcct 1606681 tgagcagagc ggatattaag caaaaagtca taactaataa tatcgccaat atagatacac 1606741 cgaactataa ggcaaaaaaa gtctctttcc aaaatttatt agatcaagaa tcctcgcgtc 1606801 ttgaagcgat aaaaacagac tatcgtcatg ttgatttttc tgatactgat tcgaattatt 1606861 caattgttgc gagcggagat acatcgtatc agcaaaacgg aaacaatgtt gatgttgaca 1606921 aagagatgac agaattggcg caaaatcaaa tcaactatca agctttggtt gaaagaatga 1606981 acggtaaatt taattcgctg aagaccgtat taacaggagg aaaatgatga cagcttttca 1607041 tagcttaaat gtttcagcat cggctttaac agctcagcga gtcagaatgg acgttgtatc 1607101 atctaactta gcaaatatgg atacgacaag agctaagcag gtgaatggag agtgggtgcc 1607161 ttacagaaga aaaatggttt cccttcagtc aaaaggtgaa tcgttctctt ccattctcaa 1607221 ttctcaaatg agcggaagcg ggaatgctgg aaacggtgtg aaggtttcaa aaattacgga 1607281 ggatgattcg gattttaatc ttgtctatga tccgacagac cctgatgcaa acgctgaagg 1607341 atatgtacaa aagcctaatg ttgatccatt aaaggaaatg gttgatcttg tcagcagcac 1607401 tagatcatac gaggcgaatg tcacggcgat gaatgccaca aagggaatgc tgatgaaggc 1607461 gttagaaatc ggaaagtagg tgaatgaatg tgattaatgc aatttctcct tttcaggttc 1607521 aaaatactca aaacactcaa aatgcaacaa atcaagtaaa caatagccaa aaaacagatt 1607581 cttcaaatca aacaagcttt tcggagcttt taaaaaactc tattagttcg ttaaatgagt 1607641 cccaagtagc ttctgacaac atgactaatg ccttggctgc aggaaaagat gtaaatcttg 1607701 atgaggtcat gatcgctgct caaaaagcta gcatctctct aactgcagca acagagttcc 1607761 gcaataaagc tgtggaagct tatcaggaga ttatgagaat gcaaatgtag ggggtctgac 1607821 gatttagaga aagagtggaa tgaccggggg ttaacatgaa tcgtactcta atgcaaatga 1607881 aaaacaaaac gagtgagttt tggaaaaata gatctaaatt acaaaagatt ttaatggtta 1607941 gtgctttagc ggcaattatt attattggaa ttattattag tgtttttgct tcaaattcta 1608001 aaatggcgcc gctgtacaaa gatttgtctg ccgaagaagc aggacaaatc aaagaagaat 1608061 tggatgcaaa aaaagtgcca aacgaacttt cgaatggcgg tacagtgatt agtgttccgg 1608121 aggatcaggt tgattctttg aaagtgcaga tggctgcaga aggacttcct aaaacgggat 1608181 caattgatta ttcgtttttt ggacagaatg ccggctttgg tttgacagac aatgagtttg 1608241 atatggtgaa agtgaaagct acacagacag aactgtcaaa cttgatcaat gaaatggacg 1608301 gtattaaaaa ttcaaaagta atgattaatc tcccgaaaga cgctgtgttt gtcggtgaag 1608361 agcaatctgc agcatctgca tcaatcgttt tgcagattca accgggttat acacttgatc 1608421 aaagccaaat caacggatta tatcatctgg tatctaaaag cgtgccaaac ctaaaagaag 1608481 ataacatcgt catcatggac caaaattcta catactacga caaatcagac agcgatgcag 1608541 ggtcctacgc ggatagttat tcttctcagc aaggaattaa gtctcaagtt gaaaaagaca 1608601 ttcaaaaaca tgtacagtca ctgctgggta cgatgatggg ccaagataaa gtcgttgtct 1608661 ccgttacagc agacattgat ttcacaaaag aaaatcggac agaagacatt gtcgaacctg 1608721 tggataaaga aaacatggaa ggcattgcag tcagcgctga aaaggtatct gaaacatatc 1608781 agggcgacgg tgcagccaac ggcggaactg ccggaaccgg cgaggaagat gttacaaatt 1608841 ataaggctga cggtgaaaat accgaaagcg ggaactacga aaaaaacagc aacaaaatca 1608901 attacgaggt taaccgaatt cataaagaaa tcgctgaaag tccttataag gtcagagatt 1608961 tagggattca agtaatggta gagccgcctg atgccaaaaa cactgcgtcg ctatcaactg 1609021 aaagacagga tgatatacaa aaaatccttt caactgtagt cagaacatct ttggataaag 1609081 atgaaacgca aaatcagaat ttatctgatg ctgatatcaa taataagatt gttgtttccg 1609141 ttcagccatt cgacggaaaa gtcaatttgg atacaaatac ggaagaatcc tcaggtatcc 1609201 cgctgtgggc atatattgta ggcggtgttt taatcgcagc gatcattgtt ctgatcatta 1609261 tgcttatcag aaagaaacgg gcgcaagagg atgaatttga ggaatatgag tatgaggttc 1609321 ctcaagaacc aatcaatttg cctgatatca acgaagagga aaatgaaaca gcggaatcag 1609381 tcagacgaaa acagcttgaa aagatggcga aagacaagcc ggaagatttt gcaaaactgc 1609441 tgagaagctg gctggccgag gattaggagg aattagaaat ggcgagacgt gatcaagata 1609501 agcttacagg aaaacaaaaa gcagccattc tcatgatttc cttggggtta gatgtgtcag 1609561 cttctgtcta taagcactta accgatgaag aaattgaaag gcttactctg gaaatatcag 1609621 gtgttcgaag cgtcgatcat caaaaaaagg atgaaatcat agaagaattt cataatatag 1609681 ccattgcgca agattatatt tctcaaggcg gtttaagcta tgcaagacaa gttctggaaa 1609741 aggcgcttgg agaggataag gcggagaaca ttctaaacag gctgacttct tctttgcagg 1609801 ttaaaccatt tgattttgcc agaaaagcgg agccagaaca aattttgaat tttatccagc 1609861 aagagcatcc gcagacgatg gcgttaatct tgtcttattt agatccagtg caggccgggc 1609921 aaattttatc cgagctgaac cctgaagtgc aggctgaggt tgcgagaaga atcgcggtca 1609981 tggatagaac gtctccagaa ataattaacg aggtagaacg gattctggaa caaaaattat 1610041 cttctgcatt tactcaggat tatacacaaa caggcggaat tgaagctgtt gtggaagtgt 1610101 taaacggggt agacagaggg acagagaaga cgatcttgga ttcattggaa attcaggatc 1610161 ccgatcttgc tgaagagatt aaaaagcgga tgtttgtctt cgaagatatt gtcacacttg 1610221 ataaccgtgc aattcagaga gtcattcgcg atgttgagaa cgacgatttg ctcctttcat 1610281 taaaggttgc aagcgaggaa gtcaaagaaa ttgtgttcaa caatatgtca cagcgtatgg 1610341 ttgaaacctt caaagaagaa atggagttta tgggccctgt acgtttgaaa gatgtagaag 1610401 aagctcaatc aagaattgta agcatcgtca gaaagcttga agaagccggt gaaattgtaa 1610461 tagcaagagg cggaggggat gatattattg tctaatatca ttaaacaaga atcatctatt 1610521 tctccacaaa aggaaaaaag aaaactttct atacaagagg tgcgtattga tcattctcac 1610581 cttttgcagg ctgaagagaa cccggaggcg cttatggccc gagtgaaaga ggaagctgac 1610641 cggatttctg agcaggcaaa cagtcatata gaaaatattc gccgtcaaat tgaacaggag 1610701 aaaaacgatt gggcggctga aaaacagaag cttattgaag aagcaaaagc cgagggcttt 1610761 gaacaaggag tagcgctggg caaagctgag gcaatgaaac agtatgcaga actgatcggc 1610821 caagcaaaca gtataactga aatgtccaga aaagctgttg aggacaagct tgaagacgct 1610881 aatgaagaaa tcgttgagct tgccgttgcc ctagcaaaaa aagtttggca gcaaaagtct 1610941 gatgataaag aggctttcct cctgcttgta caacaggtta taaacgaagt gaaggaatat 1611001 gacgatatat caatttatgt tgatccatat tactatgaga caatctttca gcaaaaagat 1611061 gaaatccagc agcttcttta taaagaatgt cggcttggca tatatgctga tgaaaaagct 1611121 caaaaaggaa cctgttatat tgaaactcct tttggcaggg tagatgcgag tgttgacaca 1611181 caattgatgc aattgaaaga taaacttctg acagcgctgg aagcaggtgc agctgaatga 1611241 agacacagag tctgatagat tgtatagaaa tgacagactc gtataaacgg tacggaaaag 1611301 tcaagcgggt aatcggcttg atgattgaat caaaagggcc agcaagctca attggtgacc 1611361 tgtgcctgat ttatgcaaaa ggacagtctg ggaaagtcat taaagctgag gtagtcggct 1611421 tccaggaaga aaatattttg cttatgcctt atttagaggc tgcgagcatt gcacctggca 1611481 gcattgtaga agctactggg gaatcacttc gggttaaagt tgggaccgga ctgatcggac 1611541 aagtcatcga tgcttttgga gaaccgcttg acggaaagct tctgccgaaa gggctttcgc 1611601 ctgtatcaac ggagcaatca ccgcctaacc cgatgaaacg gccgcctatc cgtgaaaaga 1611661 tgggtgttgg agtcagatca attgacagct tgctgacagt cggtaaaggc cagcggattg 1611721 gaatttttgc aggaagcggt gtcggaaaaa gcaccttaat ggggatgatc gccaagcaga 1611781 cagaggctga cttaaacgtc attgcacttg tcggagaacg cggacgagag gttcgggagt 1611841 ttattgaaaa agatctgggg aaagaggggc tgaaacgatc gattgtagtc gttgccacct 1611901 cagaccagcc agcattaatg agattgaaag cggcatatac agcgactgca attgccgagt 1611961 atttccgaga taaaggccaa aatgtcatgt ttatgatgga ttctgttaca agggtggcaa 1612021 tggcgcagcg agagattgga ctggctgcag gagagcctcc gacgacaaaa ggctatacac 1612081 cttcagtgtt cgctatttta cctcgtttac tagaacgaac aggtgcaaac gagcatggaa 1612141 ccattacggc attttataca gtgttggtag atggggatga catgaatgag ccgattgccg 1612201 ataccgtacg cggaatttta gacgggcata ttgtgttgga cagggcgctt gccaataaag 1612261 gccagtttcc tgcagttaac gtactaaaaa gcatcagcag ggtgatgtca aacatttcaa 1612321 caaaacagca tctggatgcg gcaaataaat tccgtgaact tttatcgaca tatcaaaatt 1612381 cggaagatct cattaatatc ggagcttaca aaagaggatc atccagagaa attgatgaag 1612441 cgatacaatt ttatccgcag cttattcaat ttttaaagca gggaacagac gaaccggctt 1612501 tattggaaga aagcattgct gcattaacta gtttgacagg aaatgaggaa taaacgtggc 1612561 ttatcaattt agattccaaa agctgctgga actaaaagaa aatgaaaaag accaatcctt 1612621 atccgaatat cagcaatcag tttctgaatt tgaaaacgtt gctgaaaaat tatatgagaa 1612681 tatgagcaaa aaggaattgc tggaacaaaa taaggaaaag aaattaaaaa gcggcatgag 1612741 tgtacaagaa atgaggcact accaacaatt tgtctcaaat cttgataata cgatctatca 1612801 ctatcaaaag cttgtcatta tgaaaagaaa tcaaatgaat caaaaacaag aaattttgac 1612861 agagaaaaac attgaagtga aaaagtttga aaaaatgcgt gaaaaacagt ttaaaatgtt 1612921 tgctcttgaa gataaagctg cagaaatgaa agaaatggac gatatttcga ttaagcagtt 1612981 tatgattcaa ggccattagg agcgaatgta atgtccggca aaaagaaaga atcaggtaag 1613041 ttccgttcgg ttttgcttat cattatcctc ccgctgatgt ttctattaat cgcagggggg 1613101 attgttcttt gggctgctgg tatcaatgtc ttaaagccga tacaggatgc tgcggcaaaa 1613161 acgccggttc ttaaagaatt ggtccctgaa accgaaaata aaaaaggcgc agcatcaagt 1613221 aaggatagca gtaatacggc agctctggaa aagaccatta aggatcaaaa aagtgaaatc 1613281 agtatattga ataaagattt agaaacaagt aaatcagaaa tcgacaggct caatcaaaag 1613341 atccgttcac ttgaaaagac ggctgaggat caaaaaaagt catcagaaga tcatactgaa 1613401 ggatcagcag actcgaaagc ttcttctgaa aatgacaaag tgatcagtgt gtacaaaagc 1613461 atggacagcg gaaaggctgc taaaattatt gcccaattaa aggagcaaga agcactgaaa 1613521 atattgaatg gcctaagcaa aaagcagctt gctgacatat tggcgaaaat gactcctgag 1613581 caagcagcaa cctatacaga aaaaattgct gccagccaag aataggggga atgaaaggtg 1613641 aagctgcttg aattagccgg acctttgctg caaaccacaa cgggttctgc cgctaaaaac 1613701 atgaaaagta gccagggagt ttttcaaaac tggcttatgt ctgaggctgg attgaaggaa 1613761 ctttcagaac aaggaaaggg aactcctaat tctgaagatc agcttttagc agatgcgctt 1613821 aaaaagatcg gtgaatggct aaatgcaagt cctgaagatc aagacaaaca aaatgcggat 1613881 cttttgcaaa cattaagcaa actgacaggg aagcaattgg atgcgaatgc tctgcaaatg 1613941 ttgcaaaatc ttttgcaagc agttgaatca aaaatgtcag gcgggacgga tcaattgctc 1614001 acagaaacgg agaaaatctt ttcagaagct aaaacggctc tgagtgccaa tgattctgct 1614061 tctgacatta atggagcact gaagtctgat aaagagcaat caaatcagga aaatgaagta 1614121 tccgagcctg caaaagagct tatctatatc cagatgttca ttagccagct cgtagaaggg 1614181 aataagctga ctgatctcgg gaatggcaat gaagctcatg ccatttacca aaatggagat 1614241 caattccttt ctgcattaga aaagaagggt gtatctcaac aactaattca ggatcttaaa 1614301 cagcaaatat tcactaaagc tgagtcaagt tcaaaacttt actcgatgac agcgtcagag 1614361 ctgaaaagtt ttcaaagctt aatggatcaa atgtctatgc ttcctcaaaa agggaccaaa 1614421 gaatggagtt tagctgaaag ccagctgaaa gccttcttgt tatcgaaatc atccgaatca 1614481 tcacaagact ttgggaagag tgttctcaca ccgctctcgc agagttcatc cagcaaaaat 1614541 gcatcggatg tttctggaag tattcagcct gtagatagta aatcaggact ccaaatgctg 1614601 ttttcggggt atcggggcat aggaggagtt caaacacttg atctgcagca gatgtcatct 1614661 gatataccaa atgccgaaac aaaaacggtg gctgatcaag tgattaatgc gtggaagcag 1614721 atgaaatata cgcctttcgg cagatcgacg ggaagtttca ctattcggct gaaccctgaa 1614781 catttaggat ttgtcacaat caagctgaca aatgaaaatg gaatgtttca gagtaaaatc 1614841 atagcatcta gccaatcagc aaaagaattg cttgaacagc atcttcctca gctgaagcaa 1614901 tcattgccga atatggccgt ccaaattgac cgttttactc ttccggtcca aagcggggat 1614961 cagccgatat acggccagct tgctgatgaa cagaaacagc agcaagaggg gcagagacag 1615021 caaagacaga aaaagcaatc aaatgatttt ggcgatctgc tcgatgaagt gtcgatggtt 1615081 gaaatggagg aagaagaatg acttctataa gttcagaata taaactgcct gaaaaaacga 1615141 acactgtgtc gacgaacaac agcagcttgg ggaaagacga gtttttaaaa atattaatga 1615201 ctcaagttca aaaccaagat ccgcttaacc cgattgacga taaagaattt atcagccaga 1615261 tggcgacttt ttcaagcttg gagcaaatga tgaatctgaa tacgacaatg actcaattcg 1615321 ttgaaaacca agatccgttt acaacgtatg ttgattggat gggaaaagaa gtatcttgga 1615381 ctgatggtaa aagtgcaaca gataaaacag gcacagtaag ctctgttaaa cattttaaag 1615441 gaaattatta tctcgttctt gatgatggga ccgagatcag tcctgcgaat gtcatgtctg 1615501 tgggacaatc atctaaataa aaacatctgg gggaatatat tatgttacgt tcactttatt 1615561 ctggaatcag cggtatgaaa aactttcaaa caaagcttga cgtaatcggt aacaacattg 1615621 ccaacgtaaa tacagtagga ttcaaaaaga gccgtgtgac ctttaaagat atggtaagcc 1615681 aaacgattgc cggcggttct gctgctggtg caacaatcgg cggaacaaac tctaagcaaa 1615741 tcggtttagg ttcatcatct ggcacaattg atacaattca ttcaacaagc gcgacacaaa 1615801 gcacaggaag aacacttgat ttagcaattg acggcgacgg ttacttccga attgatacag 1615861 gtgacgggac agcttataca agagcaggga acttctattt agataatact ggaacactgg 1615921 ttacaggtga tggctaccat gtactaaata tgaatggcgg aacaattaaa attcctactg 1615981 atgctcaaag ctttagcatt ggttctgatg gaaaggtgtc aattgttgat gctgagggga 1616041 aaacacaaga cgggggacaa atcgggattg ttacttttgc caacagtgat ggattggata 1616101 aaatcggaag caacctatac cgtgaatctt taaactctgg aacggccagt gcagcgaacc 1616161 agcctggtga cggcggaact ggtgctctta aatcaggatt tctcgaaatg tctaacgtcg 1616221 atttaactga cgaatttact gaaatgatcg tagcccagcg cggattccaa tcaaactcaa 1616281 aaattattac aacatctgat gaaatccttc aagaactggt taaccttaaa cgttaaggag 1616341 ggaggggagg cgagtaatcg cttctccgct gttttatgat taaagtaacc cgtttgaacg 1616401 ggcagccctt tacactgaat gcgctattta ttgaacagat tgaatgtttt ccggatacta 1616461 caattactct gtcaaatggt aagaagtttg tagtaaaaga agatgaagaa gctgttctgg 1616521 aaaagatcgc agctttctac cgaaaaatac aaatatttgc aatggatcaa ggaatagagg 1616581 aaccggaatg aagaaaaagt taatgatcat attactaatt attcttatcg taattggtgc 1616641 tctcggggcg gcggcttatt ttgttttagg cggaaagtcc gaaaaaagtg aagcgaaaaa 1616701 aagtattgat gaaatcgttg cgtcttctgt tgatgtagaa gagatcacaa caaatttaaa 1616761 gtctgataac attatccgtc ttgctattaa acttgaaact gattctgata aatcaaaaga 1616821 agaacttgag aaacgtgatt tccaagtgaa agacgctgtt atatcactgc tggctgatac 1616881 gaatgctgat cagattgagg gagacaaggg aaaagaaacc tttaagaagg aactaaaaga 1616941 taaaataaat agctacctcc aagaaggaaa agtagaaaaa gtgtatatta cctcctttaa 1617001 tctgcaataa agcataattt gacagaatac ggaggtgagg aaaatgtcag gagaagttct 1617061 ctcccaaaat gaaatagatg cactgctctc tgcaatatca actggtgaaa tggacgctga 1617121 agagctgaaa aaagaagaaa aagagaagaa agtcaaggtt tatgatttca aacgtgcgct 1617181 gcggttttct aaggatcaga tccgcagttt aacgagaatt catgacaatt ttgcaagact 1617241 tcttaccact catttttctg ctcagctcag aacctatatt cacatatctg tcagttctgt 1617301 tgatcaggtt ccgtatgagg aatttatcag atcgattcca aacatgacga ttctgaatct 1617361 atttgatgtt catccgatgg aaggaagaat tatgatggag gtcaacccca cgatagctta 1617421 tacgatgatg gatcgagtca tgggcgggat tggaatcagt cataacaagg ttgacagttt 1617481 gacagaaatt gaaacaaaaa tcatttctaa tttatttgaa aatgcactgg gtaattataa 1617541 agaagcttgg cagtcaattg ctgatattga accggaaatg actgagtttg aagtgaatcc 1617601 gcaatttgtt cagatggtat ctcctaatga aacagtcgtg gtgatctcgc tcaatactca 1617661 aattggtgaa atcagcggtg tcattaatct ctgtatcccg catattgtac tcgagccgct 1617721 cataccgaag ctttcagtcc actattggat gcaatcagac cgaaatgagc caaagcctga 1617781 ggaaacaaag tcgcttgaaa aacgtatcat gacagcacaa atacctgtcg tggccgagct 1617841 cggcacatct gaactgacga tagaagagtt tttaagttta gaagtcggag actgcataac 1617901 tttggacaaa tcagtcacgg atcctcttac tgtattggtc ggagataagc cgaaattttt 1617961 aggacaagcc ggccgggtga atcgaaaaca ggcagtgcaa attttagatc acgacataag 1618021 aggtgaacaa gatggagaat aatagattat ctcaagatga gattgacgcg cttcttaacg 1618081 gtactggcag cacgcttgat gagccagaga ttccggaagt agatgactta tcggaaatgg 1618141 agcgtgatgc gatcggtgaa atcggtaata tttcattcgg cagttctgcg acagcactgt 1618201 caacgctttt aaatcaaaag gtcgatatta cgactccaag cgtaacggtc attccaagaa 1618261 gtaaaatcag cgatgcgttt cctgaaccgt atgtagcgat tgaagtgaat tatacggagg 1618321 gcttcagcgg aagcaacctg ttagtcgtgg aacaaagtga cgcggcgatc attgcggact 1618381 taatgatcgg gggagacgga aaaggtgcgg acccttcact gggtgaaatc catttaagtg 1618441 cggttcaaga agcaatgaac caaatgatgg gatcggctgc cacatcaatg tctactgtat 1618501 tcagtaaaaa aattgatatt tcacctcctc gggttgaatt gctggatgtt actgaagaaa 1618561 agggtacaga ccgtattcct gatgatgaaa tgctggtgaa agtttctttc aacttaaagg 1618621 tgggagaatt aatagactcc agcattatgc aactttaccc attgacattt gcgaaagatt 1618681 taatttcaag ccttatgaac tcagaaagtg cagaggaaga agaaacggtg cagcctgaag 1618741 ttacatacga acagccgaaa gagcctgtga cgccagagcc gcgtattgaa ccgaagcaac 1618801 agcagcagcc gccaaaaagg cagggaacag caaaaaaagc agcgccagtt caggtttcac 1618861 cggtggaatt ttccgcgttt gatccaaacg aagctgtaca agcccctatt cataatctgg 1618921 atatgctttt ggatatcccg ctttcgatta ctgttgagct tggcagaacg aagagaagcg 1618981 taaaagagat tttagagctt tctgccggaa gtattatcga gcttgataaa ttagccggtg 1619041 agcctgtaga tattttagtt aatcagcgta tcgttgccaa aggcgaggtc gttgtcattg 1619101 aagaaaactt cggagtgaga gtcactgaca ttttaagcca ggcagagcgc attaataatt 1619161 taaaataacg aaacacaagg agagagatag attatggcac atagaatttt aattgtagat 1619221 gacgcagcat ttatgcgaat gatgattaaa gatattttgg ttaaaaatgg ttttgaagtt 1619281 gtggcggaag ctgaaaatgg agcacaagcg gtagagaaat ataaagagca ttcacctgac 1619341 cttgttacta tggatatcac gatgccagaa atggatggta ttacagcatt aaaagaaatt 1619401 aaacaaattg atgcgcaggc aagaatcatc atgtgttctg ctatgggaca gcaatcaatg 1619461 gttattgatg ccattcaggc cggcgctaag gatttcattg tgaaaccttt ccaggctgac 1619521 cgtgtgcttg aagcaatcaa caaaacatta aattaaaggg tgtacgactg ttgaaaaaga 1619581 gtcaatattt tattgttttt atttgttttt tcgttttatt cagtgtacat ccgattgctg 1619641 ctgccgcggc agactctgat aattcaactg taaacgaatg gtttcaaaag aaagatgaaa 1619701 aaactgcaga tcaatcagag caaaagaaag aaaaaacaac aaaaactgct gatgagacgg 1619761 agggagcggc tgctccttct gtctcagctt ttgattttgt aaagatgatt ttcgctttac 1619821 tgtttgttat cgtgctgatt tacgggctgg ttaagctcat gaacaaaaga aatcggctcc 1619881 taaagccttt tcaatatgtt gaaaatattg gcggcacatc ggtcggtcag aacagatcca 1619941 tacaattgat caaggtcggg aaaagtgtgc tcgtcgtcgg tgtaggagag acgatccagc 1620001 tgctgaaaga aattgaggat gaaaaagaga ttgaagtcat tctcagtcag catgaagagg 1620061 caatgtcaag caaaatagag tggcaaaagt ttgtgaagcc gcttaagagt tctgaacatc 1620121 agccgcagca aaaactgcct tcattttcaa aagcattaaa agagcaactt gaagagttaa 1620181 aacaaaaccg ttctgaagga aagaagaaag gcccacgtca tcatgaatga gtttataaat 1620241 attttcagtt caagcgatcc ggaaaacgta agttcgactg ttaaattact attattgtta 1620301 actgtatttt cagtggcgcc tggaatattg attcttatga cttgttttac tcgcatcgtc 1620361 attgttctgt catttgtcag aacttcactt gcgacgcaat ctatgccccc aaaccaggtt 1620421 ctaatcgggc ttgcgctgtt tttaacattt tttattatgg ctcctacttt ttcagaaatt 1620481 aataaagaag cgctgacccc attaatggac aacaaaatca gcttggatga agcgtatacg 1620541 aaagctgagg aaccgattaa agaatttatg agtaaacaca caaggcagaa ggatctggcg 1620601 ctgtttatga attacgcgaa aatggataaa cctgaatcat taaaggatat tccgttaaca 1620661 acaatggttc cggcttttgc catatcggag cttaaaacag catttcaaat aggttttatg 1620721 atttttatcc cttttttaat tatagatatg gtagtggcga gcgtcttgat gtcaatggga 1620781 atgatgatgc tgcctccagt tatgatttct ctgcccttta aaatattact ttttgttttg 1620841 gtagacggct ggtatttaat tgtgaaatct ttgcttcaga gcttttaggg taggtgctaa 1620901 acgtgagttc agaatttgta atttctatgg cggaaaaagc cgtatacgta acgctgatga 1620961 tcagcgggcc attattggct attgctttac tggtcggttt aattgtcagc atatttcagg 1621021 cgacaactca aatccaggaa cagactttgg cgtttattcc gaaaatcgtg gcggttctcc 1621081 tggctctcat tttttttggt ccgtggatgc tgtcgacgat tctttcattt acaacagagc 1621141 tgttttctaa tttaaatcgt tttgcagggt aatgtagaga tgaattcaat tattgactta 1621201 tttcctgctt ttttattggt ttttattaga atctctgctt tttttgtaac gattccgcta 1621261 tttggacatc gaaatgtgcc agctgttcat cgcataggtt ttgctttttt tcttgcggtc 1621321 atttgtttca gcaccattga taaaccgccc tctttggaga tagatgagca ctatatgctt 1621381 ttggcgttta aagaagcttt ggtcggccta tgtctgggtt taattgctta tatgatgatt 1621441 gccgcagtgc agattgccgg ctcgtttatt gattttcaaa tgggattttc aatagcaaac 1621501 gttattgatc cgcaaaccgg tgcacaaagt ccgttgattg gccagtttat ctatacgatg 1621561 gcacttttgt ttatgctgag tgtcaatgcc caccatttgt tgctggatgg tatttactac 1621621 agctttcagt atatttcagt tgatcaggca tttccgaatt tcggcgatga aaagtttgcc 1621681 tattttattg cgaaaagctt taatgcaatg tttattatcg cttttcaaat gtcagcgccg 1621741 gttgtggcca gtttgtttct agttgattta gcattaggta tcgtggctcg aactgttccg 1621801 cagttaaatg tatttgtggt cggtctgcct ttaaagatcg ctgtcagttt cattatgctc 1621861 attgtatgta tgtccgttat cttcgtcgtt gtccggaatg ttttcagttt aacgattgaa 1621921 acgatgcgga atcttttagc attggtcggt gtttcttaat gaagcttaga gttgacctgc 1621981 agttttttgc gggagagaag acagaaaaag ccactccgaa aaaacggaag gatacgcgaa 1622041 aaaaagggca ggtagccaaa agctcggatg tcaataccgc cgtttcttta ctggtaatat 1622101 tcctttcgct tattgcaatt ggtccgtata tgagagacag gctgctgtca ttcatagaaa 1622161 cattttatac cgaatcgctc acaatgaagc tctcagaatc aaatgtgcat acattgtttg 1622221 tcagcttatt aaaggatatg ggcatgatac tcgcaccgat cttgcttgtt gctcttgttg 1622281 caggagtcgt aagcaactat atgcaggttg ggttcttgtt ttctgctgaa gtgatacagc 1622341 ctaagcttga aaaactggat ccgatcaaag gctttaaacg aatatacagt atgagggcga 1622401 ttgtagagct gattaaatca attttgaaaa tcgtagtcgt cggttttgcg gcttttgctg 1622461 tgctttggct gcattatgga gaaattctcc ggcttcctct cctgacaccc gaagaggcac 1622521 tttctttcgt ttcaaaactc actttgtgga tgggactaag cggtgcaggt gcattgttga 1622581 ttcttgctgg tctcgactat ttatatcaga gatttgacta tgagaaaaat atcaaaatgt 1622641 caaaacaaga tataaaagat gagtacaaaa aatctgaagg agacccgatt atcaagtcta 1622701 aaattaaaca aagacagcgg gaaatggcga tgaggcggat gatgcaggaa gttccaaaag 1622761 cagatgtcat tatcacaaac ccgactcact atgcgattgc tttgaaatat gatgaagaaa 1622821 aaatggacgc accttatatt gttgcaaaag gcgtcgacca ccttgcgtta aaaatcagga 1622881 aaattgctaa agagcatgat gtcatgatgg tagaaaacag accgcttgcc cgtgcgttat 1622941 atgatcaagt ggaaattgac caggcagtgc cggaagaatt ttttaaagtt ttagcagaaa 1623001 ttctggctta cgtatataaa acaaaacaaa aagtatattg aatttttcga tttaaaagga 1623061 gagaaaaaac agcatgtcaa caagagattt atccgtttta ataagtgttg tcctcattgt 1623121 ggcgatgctg gtgattccat ttcctccatg gctgttaagt attttgatca ttattaatat 1623181 ttctcttgcg ttgatcgtgc ttctcaccac aatgaatatg caggaagcgc ttcagttttc 1623241 gatttttccg tcactgttgc tgcttttgac cctatttcgt ttgggcttga acgtctcaac 1623301 tacccgttca attctttcac acggtgaggg aggtaaagtc gtcgagactt tcggaaattt 1623361 cgttgtcggc ggaaatgtat tagttggact cgttgtattt atcatcctta ttattattca 1623421 gtttatcgtc attacaaaag gtgctgaacg tgtttccgag gttgcagcaa ggtttacgct 1623481 ggacgcaatg ccggggaagc agatgagtat tgatgctgat ttaaacgcag ggatgattac 1623541 cgaacaggaa gcgaagcatc gccgcgaaaa agtggcaaga gaagcagact tttatggagc 1623601 aatggacggt gccagtaaat ttgtaaaagg tgacgccatt gccggaatca tcattgtgat 1623661 gatcaatatt attttcggaa tcgtgatcgg aatgcttcag cagggcatgt ccattcaaga 1623721 agctgcttca cactttacga tgctgactgt aggggatgga attgtttcgc aaatcccggc 1623781 actgttaatt tctacggcta cgggtattgt ggtcacaaga gctgcatctg aaggaaactt 1623841 agggcatgac attacaggcc agctgtttgc gtatccaaag cttttatacg tcgcagcagc 1623901 tacgatcatg cttttaggta ttttcactcc gatcggcatc cttctgacgg ggccgcttgc 1623961 gggattgctt gcttttggcg catatacact atctaaatca ggtaaggaaa aagaagaagt 1624021 ggatgagatt cttgaggaag aggctgaggt ggacgagctt aaaagccctg aaagtgttgt 1624081 tcagcttctg catatagatc cgatagaatt tgagtttgga tatggcctga taccgcttgc 1624141 tgatgccaat caaggcggtg atttattaga ccgaattgtt atgatacgcc gtcagttggc 1624201 tttggaactc gggcttgtca ttcctgtcgt gcgaatcaga gataatatag cgttgcagcc 1624261 taatgaatac cgattgaaaa ttaaaggaaa cgaagtagca aaaggcgagc tgttgcttga 1624321 tcattattta gcgatgtcgc ctactcctga ggacgatctc attgaaggga ttgaaacagt 1624381 ggagccttca ttcggactgc cggctaaatg gattagcgaa gcggtaaagg atgaagccga 1624441 catgcttggt tatacagtag ttgatcctgc atcagtcgtt tcaacgcata ttacggagaa 1624501 aattaagcag catgcccacg aattgatcgg aaggcaggag acaaaacagc tgatcgatca 1624561 cttgaaagaa tcgtatccag tcctggttga agaggttacg ccgaatccat tgtctgtcgg 1624621 tgatattcag aaagtgcttg ctaagctttt aaaagaaaaa gtttcaattc gaaacttagt 1624681 aacgattttt gaaacacttg ctgactatgg gaaattaaca acagattctg atctcttgac 1624741 agagtataca agacaagcgc ttgctaaaca aattacagcc cagtttgcca aagaaaatga 1624801 agtgttgaag gttgttactt gttccggccg tgtagaaaaa gcaatagcag acggtgtgca 1624861 gcagacggaa cacgggaact atttatcact tgaaccagat atttcagaaa gtatagtgcg 1624921 ctctgtcgcc aaagaagctg aacagctctc attacgtcag gaaaccgcga ttcttctttg 1624981 ctcgccgcct gtcagaatgt atgtgaagca gctactggaa cggtacttcc ctgatcttcc 1625041 ggtactctct tataacgaac ttgaggcgaa tgttgaggta caaagcattg gagtggtgga 1625101 tatttaatga aaataaaaaa atttactgct gcttcaatgc aagaagcggc acttctcatc 1625161 agaaaagagt taggtaatga agcggtcata ttaaattcga aaaaaattaa aaagcgaaaa 1625221 tggtttggcc tcgtcaacaa gcctgctgtt gaagtaatcg ccgtattgga tcaggacttt 1625281 cttgagaaaa aaacgcctca gaaggcagct gaaccgaaac aaacattaaa aactccggtc 1625341 agcagtccaa aaatagagga gagaacatat ccccctcaaa ttccggcgca acaggagcta 1625401 ggtgattttt cagcatatca atctgtactt cctgagccgc tgcgaaaagc agaaaagctt 1625461 ttgcaagaaa cagggatcaa agagtctacg aaaacgaaca ctctgaaaaa attgcttcgc 1625521 ttctctgttg aagcaggcgg cttgactgaa gaaaatgttg tcggcaaact tcaggaaata 1625581 ctatgcgata tgctgccctc agcagacaag tggcaggagc caattcattc aaaatatatc 1625641 gttctctttg gttcaacagg ggctggtaaa acaactacac tggctaaact cgcagccata 1625701 tctatgcttg aaaaacataa aaaaatcgct tttattacaa cagatacgta tcgtattgca 1625761 gctgttgaac agttgaaaac atacgctgaa ctgctgcagg ctcctctgga agtttgctat 1625821 acaaaagaag aatttcagca ggcgaaggag ctattttctg agtatgatca tgtgtttgtt 1625881 gatacagctg gaagaaactt caaagacccg caatacattg atgaactgaa agaaacgatt 1625941 ccttttgaga gcagcattca gtcatttctt gttttatccg cgactgcaaa atatgaagat 1626001 atgaagcata ttgtcaaacg gttttcatcc gtccctgtca atcagtatat ttttacgaaa 1626061 atagatgaaa cgacttcctt aggttctgta tttaatatac tggcagaatc aaaaataggt 1626121 gtcgggttta tgactaacgg ccagaatgtg cctgaggata tacagactgt atctccactt 1626181 ggttttgtga ggatgctgtg cagatgaaca gatatgacca agcagcaact ttacgggcga 1626241 aaatggaaaa acgtgagcgc gttctgccaa tggtttattc acaaaaagcg aagacacttg 1626301 ctgtcatcag cggcaagggc ggtgtcggaa aatccaatat taccttaaat atggcacttg 1626361 cgctgcagga taaaggtaag aaggtgctgc tcatcgacct tgatatcggg atggggaaca 1626421 ttgatatatt aataggaaat tcatcgtctg ccacgataat cgatgtttta accgatcgta 1626481 agcctttgct gcagtcatta tccgttggcc caaagggttt gcggtatata tcagggggaa 1626541 ccggtcttga tgtgatgttt cagctcgatc agagaaaatg gacgtttttt gccaatgaac 1626601 tttctcatgc attaagccag ttcgattatg tgctgtttga catgggagca ggcttatcaa 1626661 aagatcaact gccttttatt ttatcagcag aagatatttt gattattaca actcccgagc 1626721 cgacggccat tatggacgca tacagcgctg tcaagcactt ggttttgaca gaaaataagc 1626781 tttcaatgaa ggtggctgtc aatcggtgcc gtgaccaaaa ggaagggctt gacgcttttg 1626841 cccgcctctc ccgtacaatt catatgtttt tggatgttca ggttcagttt gccggttccg 1626901 tttctgacga tgtgatcgtg agcaaagcgg ttgtcgaaca ggttcctttt ttcataaaaa 1626961 gccctcaggc aaaagccagc cggtcagtcc gtattttagc ggacgccttg tttgaaagag 1627021 aagaaacgag acacaaagaa gacaaacaga catttattga gaaattatct tcttttttaa 1627081 tgaggagggc ttaatttgat tcgtgtgctt gtagttgatg attcagcttt tatgagaaaa 1627141 atgataagtg attttctgac cgaagaaaag cagatagaag taatcggaac tgcgagaaac 1627201 ggagaagaag cgcttaagaa gattgaatta ttaaaaccgg atgttattac tcttgatgtt 1627261 gaaatgccgg tcatgaatgg gacagatacg ctccgcaaaa ttattgagat ttataacttg 1627321 ccggtcatta tggtgtctag ccagaccgag aaaggtaaag aatgcacaat taattgtttg 1627381 gagatcggtg cctttgactt tatcacaaag ccatcaggct caatatctct ggatctatac 1627441 aaaattaaag aacaactagt tgagcgtgtc gtcgcggcag gactttccgg caagcggaaa 1627501 cgtcctgttt cccagacagt tcggcccgaa cctattgtgc gtgctgtcgt taagcctgaa 1627561 ttaagcaaac cgaaacctgg cacgggcaga caaattgtgt gtatcggcac atcaacaggc 1627621 ggtccacggg cgttacaaaa ggtgataccg aagctcccta aggatttgaa cgcaccagtg 1627681 gttgtcgttc agcacatgcc tgaagggttt actgcttctt tggctgatcg gctgaatcat 1627741 ttatctgaca ttcaggtaaa agaagcaaaa gatggtgaag cagctcttaa cggctgtgtt 1627801 tacatagcac cgggcggaaa aaacatatcc gttattaaaa acagcgaagg actccaggtt 1627861 gtgcttgata accatgacac accaagccgt cataaaccat ctgctgatta tttattccgt 1627921 tctgtcggga aactgacaga ttatgaaaaa gtagcggtta tcatgaccgg aatgggcagt 1627981 gacggcactg ctggactaaa ggacatgcta acagccggca atgtgaaagc cattgcggag 1628041 tctgaagaat cttgtgtcgt atacgggatg ccaaaagctg ctgttaaagc gggtctcatt 1628101 catgagatta aacatgtgga agatatcgca gcatccatca caagctgtgt gaaaaaagag 1628161 agggtgtgat tcaaatggat atgaatcagt atttagatgt ctttattgat gagagtaaag 1628221 aacatttaca aacatgtaat gaaaagcttc ttcttttaga gaaagacccg actgatcttc 1628281 agctcgtaca tgatatattc agggctgccc atacattaaa aggaatgagc gcaacgatgg 1628341 gctacacgga tttagcacat cttacccatc tgcttgaaaa cgtgctggat gcaatccgaa 1628401 acggagacat ggaagtcacc tcagactggc tggatatttt gtttgaagct ctggatcacc 1628461 tggaaacaat ggttcagtct attattgatg gcggggatgg taaaagagat atctcagaag 1628521 tgagtgccaa gcttgatgtg aatggtgcgc acgctgaatc cgctgcctcc gctgaacctg 1628581 cagaagcaca gagttcagca tctgattggg aatatgatga atttgaacgc acagttatac 1628641 aagaagcgga ggagcaaggc ttcaaacgat atgaaatcaa gatttctctg aacgaaaact 1628701 gtatgttaaa agcagttcgt gtctatatgg tgtttgaaaa actaaatgaa gtcggagaag 1628761 tagccaaaac aattccaagt gctgaagtgc ttgaaacaga agattttgga actgactttc 1628821 aagtttgttt cttaacacat caatcagcgg aagacattga acaattaatc aatggcgtgt 1628881 cggaaattga gcatgttgaa gtcattcaag gggctccttt aacatcagct gaaaagcctg 1628941 aagaatctaa gcaagaagat tcaccagcag cagctgtacc tgcgaagcag gagaaacaaa 1629001 aacagcctgc taaaaacgat gaacaggcga agcattcagc cggcggatct aaaacaattc 1629061 gtgtcaacat tgacaggctt gattctttaa tgaacttatt tgaagagctt gtcattgacc 1629121 gcgggcgtct cgagcagatt gcgaaagagc ttgagcataa tgaactgact gaaacggttg 1629181 aacgaatgac gagaatttcc ggagatttgc aatcgattat tctgaatatg agaatggtcc 1629241 cggttgaaac tgtttttaac agattcccga gaatgattcg ccagcttcag aaagagctga 1629301 ataaaaaaat tgaactctcg atcatcggtg cggaaactga actggatcgt acagtaattg 1629361 atgaaatcgg agatccactc gttcacttga tcagaaacag tattgaccat ggtatcgagg 1629421 cgccggaaac acgtttgcaa aagggaaaac cggaatcagg aaaagttgtg cttaaagctt 1629481 atcacagcgg caaccatgtc tttatcgaag tagaggatga cggcgcaggc cttaatcgaa 1629541 aaaaaattct ggaaaaagcg cttgagcgcg gggtcataac ggaaaaagaa gctgaaacct 1629601 tagaagacaa ccaaatttac gaattgattt ttgctccggg gttctcaact gctgaccaaa 1629661 tttctgatat ttccggccgc ggtgtaggac ttgacgttgt aaaaaacaaa ctggagtctc 1629721 ttggcggttc agtcagtgtg aaatcagccg agggtcaagg ctctctattc agcatccagc 1629781 tgccgcttac cttgtctatt atttcagttc tgctgattaa gttggaagaa gagacatttg 1629841 ccattccgat ttcttcaatc attgagacag cagttattga cagaaaagac attttgcaaa 1629901 cgcatgaccg tgaagtgatt gactttagag ggcatattgt ccctgtcgtt tatttaaaag 1629961 aagagtttaa aatagaagat acaagaaaag atgcggaaca gctccatatc attgtcgtga 1630021 aaaaaggcga caaacctact gcatttgtgg tggactcctt tattggccag caggaagttg 1630081 tgctgaaatc actcggagat tatttaacaa acgtctttgc aatttccgga gctactattt 1630141 taggagacgg agaagtagcg ctcattattg attgtaatgc actgattatt taaccattcg 1630201 aggaggtgtc tcacatgact gcagaaatta aaacaggcga aaaaatgata gtctttatgg 1630261 taaatggcaa agaatatgcc atttccgtca ctcaggtgaa atcaattgaa aaatggcaaa 1630321 agccaacgag ggtacctggc gtcgaaccat atatttgcgg ggtaatcaat ttacgcgggg 1630381 tggtgactcc ggttattgat ttaagaaaac gcctgaattt gccagagtat gaaattacag 1630441 atgaaacacg aattatcatt attgcttatc gtgatattga agtcggctgg attgtggatg 1630501 aagcgaatga tgtgattacc gtacacgaaa gtgaaataga atctgctcca gaaggcgttc 1630561 agaaagatac ggatgtgtcg atcgaacaga ttgtgaaaca agagaacaga ctcttaaata 1630621 ttattgatgc gaacgcggtt ttggataaag aatcatctca gtccgctgtg cccgatcaag 1630681 cttaatctta aaggggttat gacatgagta tttttaatgg aatcaaagaa gagcagatgg 1630741 acattttgcg ggaagtcggc aatataggcg ccggccactc cgcctctgca atggcccagc 1630801 tgttaaatag aaagatagat atggaagtcc catttgcaaa gctgctgtct tttgatgagc 1630861 ttgttgattt tttcggcggc gccgatgtcc cggttgccag catcttttta agaatggaag 1630921 gcgatttaac gggttcaatg ttctttataa tgcctttttt tcaggcggag cagtttatca 1630981 gagagctgat tggaaacccc gattttgaca tagaggactt aggtgaagac cacatgagct 1631041 catccgcttt gcatgaactg ggcaatattt tagcggggtc atatttaaca gctttggcgg 1631101 atttgacgaa actccagctc tatccaagtg ttcctgaagt ctcattggac atgttcggag 1631161 ctgtgatcag cgaagggctg atggagctca gtcaggttgg agaacacgcc attgttgtcg 1631221 acacgtcaat ttttgaccaa agccatcagc aggagctgaa agcgcatatg tttatgctgc 1631281 cggactatga ttcatttgaa aagctctttg tcgccttagg tgcatcatta tgagtacaac 1631341 tgaggctgtt gttataaagg ttgggattgc tgacgtgaag atcgcccgct tcccggatac 1631401 catccggacc tctggtttgg gctcatgtgt ggggctggtg ctttatgata aagaaaagca 1631461 aacggcgggt cttgttcatg tcatgcttcc ggattcgacg ttatcgaaaa ctgccgagct 1631521 caaccgggct aagtacgctg acaccgccgt acagaccacg attgatatgc tgatagaagc 1631581 gggatgccgg aaatttgcat taaaagcaaa gctggccggc ggatcagaga tgtttaaatt 1631641 taaatcgaca aatgatttga tgaagatcgg accgagaaat gtattagcga taaaagaaca 1631701 gctgtcttta tttaatattc ctattattag tgaagatacg ggcggctcaa gcggccggac 1631761 gatagaattt gaaccgaagt cctgcatgct gcatattcga actgttaaac aaggtgaaaa 1631821 aacgatttaa ttaaggtatt agggggataa caatgcaatc cttgaattat gaagatcagg 1631881 tgctttggac gcgctggaaa gagtggaaag atcctaaagc cggtgacgac ttaatgcgcc 1631941 gttacatgcc gcttgtcaca tatcatgtag gcagaatttc tgtcggactg ccgaaatcag 1632001 tgcataaaga cgatcttatg agccttggta tgcttggttt atatgatgcc cttgaaaaat 1632061 ttgaccccag ccgggactta aaatttgata cctacgcctc gtttagaatt cgcggcgcaa 1632121 tcatagacgg gcttcgtaaa gaagattggc tgcccagaac ctcgcgcgaa aaaacaaaaa 1632181 aggttgaagc agcaattgaa aagcttgaac agcggtatct tcggaatgta tcgcccgcgg 1632241 aaattgcaga ggaactcgga atgacggtac aggatgtcgt gtcaacaatg aatgaaggtt 1632301 tttttgcaaa tctgctgtca attgatgaaa agctccatga tcaagatgac ggggaaaaca 1632361 ttcaagtcat gatcagagat gacaaaaatg ttccgcctga agaaaagatt atgaaggatg 1632421 aactgattgc acagcttgcg gaaaaaattc acgaactctc tgaaaaagaa cagctggttg 1632481 tcagtttgtt ctacaaagag gagttgacac tgacagaaat cggacaagta ttaaatcttt 1632541 ctacgtcccg catatctcag atccattcaa aggcattatt taaattaaag aatctgctgg 1632601 aaaaagtgat acaataatga atttcatggt tagcgagtga aaaacatgtc aacactatta 1632661 tggcttttaa gctttatgct ccacggcgtt cttctgtacg ctgtcattat cctgtatacg 1632721 aggctcgctg cagtgaaaga aacagaaaaa cagcaaaaac agatacttga agagacggaa 1632781 aacaccttgg cggcatttct gcttgaatta aaagaagaaa atgagaaact gatagaaaat 1632841 aaagcttcat ctgcaagtca atcagatgaa gaatcccaaa agtcaggcct tcagacctct 1632901 gaaacatatc aagagcggga tccagtccaa gaggcagaga atcttcctga acatattgaa 1632961 ggtctgatta cagaggttga ccgtcgggaa gagctcgtaa acagtgaggt ccaatcattt 1633021 gaagaccagg tcatagaatt atatgaacag ggatattcgg caagtcaaat tgcccagaaa 1633081 atgaagagcg gaaagacaga aatcgagcta tttttaaaat ttcgctccaa aggtgtaaag 1633141 gattcttgat tgtcggataa agctgtgtta tattatgtct tggtgttaaa tacacacgct 1633201 taacgattta tgcagagggt gctgcaggcg gcagttctgt acaaaaatga cctaagcgga 1633261 ggaaaaaaac cattatatta ggaggaaata acatgtcagt catttctatg aagcaattgc 1633321 ttgaagctgg tgttcacttc ggtcaccaaa cacgccgttg gaacccaaaa atgaagcgtt 1633381 acattttcac ggagcgtaac ggaatctaca tcattgacct tcaaaaaaca gtcaaaaaag 1633441 tagaggaagc ttacaacttc actaaaaatc ttgctgctga aggcggaaaa atccttttcg 1633501 tcggaacaaa aaaacaagct caagattctg ttaaagaaga agctcaacgc tctggcatgt 1633561 actatgtcaa ccaacgctgg ttgggcggta cattaacaaa cttcgaaaca atccaaaaac 1633621 gtattaaacg tcttaaagac attgaaaaaa tgcaagaaaa cggtacgttt gatgtacttc 1633681 ctaaaaaaga agtcgttcaa ttgaaaaaag aattagagcg tcttgaaaaa ttcctaggcg 1633741 gaattaaaga tatgaaggat cttcctgatg cattattcat catcgatcct cgcaaagagc 1633801 gcatcgctgt tgcggaagct cgcaaattaa acatccctat catcggtatc gtagatacta 1633861 actgtgatcc agatgaaatc gatgttgtta tcccagcgaa cgatgacgct atccgcgctg 1633921 ttaaacttct aacttctaaa atggcagatg caatcttaga agcgaagcaa ggcgaagaag 1633981 aagcggaagt tgctgaagaa actgcaccag aaacagaaac aacaactgcg taacctattc 1634041 aaaaggtgat aagagggact gccttttatc accttttttc aagaaaaatg tgtaatatac 1634101 atactcttgt ttaaacatat aaggaggaat acaaatggca attactgcac agcaagtaaa 1634161 agaactgcgt gaaaaaactg gcgcgggcat gatggattgt aaaaaagcgt taactgaaac 1634221 tgacggagat atggacaaag caattgacct tttaagagaa aaaggaattg caaaagcagc 1634281 gaaaaaagct gaccgtatcg cagcagaagg ttctactctt attaaaactg acggcaacaa 1634341 aggcgttatc ctagaagtaa actctgaaac tgatttcgtt gcgaaaaacg aaggttttaa 1634401 agagcttctt aacactttag ctgaccacct tcttgcaaac acgccagctg atgttgaaga 1634461 agcaatgggc caaaaaatgg aaaatggctc aactgttgaa gagtacatca caagcgcagt 1634521 tgctaaaatc ggtgagaaaa tcactcttcg ccgctttaca gttcttacaa aagacgacag 1634581 ctctgcattc ggtgcgtacc ttcacatggg cggccgcatc ggtgtattaa ctgttctcaa 1634641 cggtacaact gatgaagaaa ctgcgaaaga tatcgcaatg cacgttgctg cagttaaccc 1634701 tcgttacatt tctcgtgatc aagtatctga agaagaaaca aatcatgagc gtcaaatctt 1634761 aactcagcaa gccctccaag aaggcaaacc tgaaaacatc gtagcgaaaa tggttgaagg 1634821 ccgtctgaac aaattcttcg aagaaatttg tctattagac caagcgttcg ttaaaaaccc 1634881 agatgaaaaa gtgaaacaag ttattgcagc gaaaaacgct actgttcaaa cttttgtccg 1634941 ctatgaagtt ggagaaggca tcgaaaaacg tcaagaaaac tttgctgaag aagtaatgaa 1635001 ccaagtgaaa aaataatggt gaaaagattt cgcggctaag tcgcgtcttt tcaggcagta 1635061 taggggacac attttgtgtt ccctattttt aaaactatat ttacaaacct ttttttctct 1635121 tgcataatag aaaacggcaa tgtttacact tggaggttat catggaaaaa ccaaaataca 1635181 aacgtatcgt attaaagctt agcggggaag cattggcagg agaacaggga aatggaatta 1635241 acccgactgt cattcaatcc attgcaaagc aagtgaagga aatcgctgag cttgaagtcg 1635301 aagtggctgt tgttgtaggc ggcggcaact tatggcgcgg aaaaacagga agtgacctgg 1635361 gcatggaccg cgcgactgct gactatatgg gaatgctggc gacagtaatg aattcgcttg 1635421 ctcttcaaga cagcttggaa acactcggaa tccagtccag agtgcaaaca tccattgaaa 1635481 tgagacaagt tgctgaaccg tacataagaa gaaaagcgat acgccactta gagaaaaaac 1635541 gtgtcgttat tttcgctgcg ggcacaggaa acccatattt ctcaactgat acgacagctg 1635601 cactgcgggc tgctgaaatt gaggcagacg ttattttaat ggctaaaaat aacgttgacg 1635661 gtgtgtataa tgctgatcct agaaaagatg aatcagctgt taagtatgaa tcactttctt 1635721 atcttgacgt tcttaaagac ggcctggaag tcatggattc aacagcttcc tctttatgca 1635781 tggacaatga cattccgctt atcgtctttt ctattatgga agaaggaaat atcaaacgtg 1635841 ccgttatcgg tgaatcaatc ggaacgatcg tgagggggaa ataacgtgtc aaaagaagta 1635901 ttaactcaaa caaaagaaaa aatggaaaaa gcaattgctg cttatcagcg cgaattggct 1635961 actgtacgcg caggccgtgc aaatccatca ttattagata aagtaacggt tgaatattac 1636021 ggagcgcaga cacctttaaa tcagttgtct tctattaacg tgcctgaagc tcgtatgctc 1636081 gttatcacgc catacgataa aacagcaatc ggtgatatcg aaaaagcgat tttaaaagct 1636141 gatttaggtc ttacaccaac aagtgacggc aatatgattc gaattgcaat tccggcacta 1636201 acagaagaga gacggaaaga attagtgaaa gttgtaaaaa aatatgctga agaagcaaaa 1636261 gtagctgttc gtaacgttcg ccgtgatgct aacgatgatc tcaaaaaact tgagaaaaac 1636321 ggagacatta ctgaggatga actgcgtgct tccactgaag acgttcaaaa actgacagat 1636381 gaatatgtgt caaaaattga cagtgtcaca aaagacaaag aaaaagaaat catggaagtt 1636441 taatgaaaaa ctatgtacaa tagataatag tgaaaagacc ctctcatgtt tacagggggt 1636501 ttttttgtta atactgttga ttacattgat tatcagcagg gaatgtaacc tttttgggtg 1636561 acggaggaat ctcatgctca acatactcaa aaattggaag aatcagcaaa ctgcggcttc 1636621 caacttagaa cgttatacaa aagaagacat acttaaggga gaaattcccg aacacatcgc 1636681 cattatcatg gatggaaatg gccgttgggc taaaaaacgc tctcttccca gaattgcagg 1636741 ccaccatgaa gggatgaagg tggtaaaaag gaccacgaag ctcgcaaacg aattaggtgt 1636801 caaagtactg acattgtatg cattttcaac agaaaactgg aaaagaccga aaatggaggt 1636861 cgatttttta atgaagcttc cggaagaatt tttgaatacg tatcttccag agcttgttga 1636921 ggaaaatgta caggttcgga tcattgggga tgaaacggct ttgccggcgc acacattacg 1636981 tgcgattgaa aaagctgtac aggacacggc gcaaaacgac ggaatgatcc ttaattttgc 1637041 tcttaactat ggaggccgta ctgaaattgt cagtgctgca aaatcactcg cggaaaaagt 1637101 gaaggaaggc tctttgaata ttgaagacat tgatgaatcg cttttttcta cttatttgat 1637161 gactgaatct ttgcaggatc ctgaactttt aattcgaacg agcggcgaga taaggctgag 1637221 taattttatg ctatggcagg ttgcctacag tgaatttgtc tttactgacg tcttgtggcc 1637281 tgactttaaa gaagatcact tcttgcaggc gttaggagag tttcagcaga gaggccggag 1637341 gtttggcgga atttagagga tggtggacat gaaacaaaga attttgacag gtgttctggc 1637401 agcaattgta tttttatttt tggttattgt cgggaaattg ccgttcacca tattaattta 1637461 tgctatgggc agtgtggcgc tttttgaact tttacggatg aaaaagctga agctggtttc 1637521 actgccgggt ttgatcggtc ttttattatt gtggatgttc ttattaccaa gccagtattc 1637581 gttttttgaa gcggacggga tttccaaaat ggaaatcgct ttatttgcgg tactgctatt 1637641 gctgacttac acagtgttgg tcaagaacac ctttactttt gatgaagtcg ggtttattac 1637701 gcttgcagca atttacatcg gaatgtgttt tcattatttt atcgaaatca gaaatcttga 1637761 ccaatacgga ttaacataca ttttttatgc gtgtgttgtc atttggtcca ccgattccgg 1637821 tgcctatttt gtcggtaaat cgcttgggaa gcggaaactg tggcctgaaa tcagtccgaa 1637881 taaaacagtg gaagggtttg caggcggaat tgtcatcgca cttgtattgg cgacgatttt 1637941 tcagcttgtt gcacaacttc cgatcccgta tatctatctg ctgttgatca cgctgttttt 1638001 gtctgttttt ggacaactgg gagatttagt ggaatccgcc ttgaaaagac attacgatgt 1638061 aaaggattct gggaatattc ttcccgggca tggcggtata ttagaccgtt ttgacagttt 1638121 cttgtttgtc atgcctttct tgtactttct gcttgccctt ttttcataaa aaagtctaat 1638181 atgaatatga gactgatcat gcagcaataa gaataggagt agtggcaact ttgaaaaata 1638241 tttgtctttt aggagcaaca ggatcaatcg gcgaacagac tcttgatgta ctgcgtgcac 1638301 atcaagacca atttcagctg gtatctatgt cgtttggcag aaatattgat aaggccgttc 1638361 caatgattga ggtctttcag ccgaagtttg tctctgtcgg tgatctggat acatatcata 1638421 aattaaaaca aatgtctttt tcttttgaat gccaaatcgg gctgggagaa gaaggactga 1638481 tagaagcagc agtgatggag gaggttgaca ttgttgtcaa cgctttgctt ggaagcgtcg 1638541 gtcttatccc gacattaaag gcaattgaac agaaaaaaac aattgcgctt gcaaataagg 1638601 aaactcttgt cactgcaggg catatagtaa aagaacatgc taagaaatat gatgttccgc 1638661 tgctgcctgt tgacagtgag cattcagcca tttttcaagc tcttcaaggc gaacaggcta 1638721 aaaacattga acgcctcatc attacggcat ccggcggaag ttttcgggac aagacgcggg 1638781 aggagctcga atcagtaacg gttgaagatg cattaaaaca tccaaactgg tcaatgggtg 1638841 caaaaattac aattgattcg gctacaatga tgaataaggg attagaggtg atcgaggcac 1638901 actggctttt cgatatacct tatgaacaaa ttgatgtggt tttacataag gagagcatca 1638961 tccattcaat ggttgagttc catgataaaa gtgtgatcgc acagctcgga actccggata 1639021 tgagagtccc cattcaatat gcgctcactt atcctgaccg attgccatta ccagatgcga 1639081 aaaggcttga attatgggaa atcggcagcc ttcattttga gaaagctgat tttgacaggt 1639141 tccgatgctt acaatttgct tttgaatcag gtaaaatagg aggaacaatg ccgacagtgc 1639201 taaatgcggc aaacgaagta gctgtcgctg cctttttagc tggcaagata ccgtttttgg 1639261 ctattgaaga ctgtatcgaa aaggcactaa cccgccatca attactgaaa aaaccgagcc 1639321 tggcggacat tcaagaagtg gacaaagata cccggggata cgtcaattca atactcacat 1639381 aaggtggtat gttcgtgaat acagttatag cgtttatcat tattttcgga acgctcgttt 1639441 tcttccatga actgggccat ttattgctag cccaaagagc gggaattctc tgccgtgaat 1639501 ttgcgatcgg cttcggtcca aagatttttt ctttcaaaaa aaatgaaaca gtttatacga 1639561 tcaggctgct tccggtcggc ggatttgttc gtatggccgg cgaagatccg gaaatgattg 1639621 aggtgaaacc cggatacacg gtcgggcttc tgtttaataa ggaagatcaa gttgagaaag 1639681 tcatcatcaa tcaaaaggaa aaatatccgg atgctttagt cattgaagtg gaaacagcgg 1639741 atctagagca tgacatgaag atcaccggtt atgaacaggg gaaagaggac gaactttcca 1639801 gctttactgt cagcgaaaca tcctttttta ttgtagacgg agaagaagtg cagattgcgc 1639861 cgtataatcg ccaatttggt tccaaacctg tatggcagcg gattaaagca attgctgcag 1639921 ggccgattat gaactttatt ttagcttacg tcattttagt gatgcttggg ctgattcaag 1639981 gcgtaccgtc aaatgaacct atgctcgggc agctgacaga caatggacgg gcggctgaag 1640041 cagggctaaa agaaggggat tatatccaaa gcattaacgg agagaaaatg aggtcttgga 1640101 ctgacattgt ctccgctgta aaagaaaacc cggagaaaga aatggacgtt gcagtaaaaa 1640161 gagataacaa aacgcttcat atttcggtga ctccggaagc tgttaaagat gagaacaaaa 1640221 aaacaatcgg acgtttcggt tcctatgcgc cgactgaaaa aggcgtactc tcagcggttg 1640281 cttacggcgc gacatcaaca gttgatgtca ccaaagccat tttaaccaat ctgagcaaat 1640341 tagtaacagg ccaatttaaa ctcgatatgc tgtcaggtcc tgtcggcata tatgacatga 1640401 cagaccaagt ggcgaaaaca gggatcgtga acttatttca gtttgcggcg tttttaagca 1640461 ttaaccttgg gattgtcaac ctgcttccga ttccggcact tgacggagga agactgttgt 1640521 ttctatttat tgaagcgatt cggggcaaac cgattaacag ggaaaaagaa gcatttgttg 1640581 tgtttatcgg agtagctttc ttaatgcttc ttatgctggt tgtcacatgg aacgatatcc 1640641 agcggctgtt tttgtaaacg aaaagtaaat caatcagagg tgcgaagaaa tgagacaaag 1640701 cttgacgctt attcctacgc tccgtgaagt tccagctgat gccgaagcaa aaagtcatca 1640761 gcttcttctg agagcaggat ttatcagaca gaatacgagc ggggtataca gctatatgcc 1640821 tcttgcgtat aaggtgattc aaaacattca gcagattgtt cgagaggaaa tggagaaaat 1640881 tgatgccgta gaaatgctca tgcccgcatt gcagcaggca gagacatggc aggaatcagg 1640941 cagatggtat acgtatggtc ccgaactgat gagactaaaa gaccgtcatg gccgtgaatt 1641001 tgctttaggg gcaacgcatg aagaggttat cacttcgctt gttcgcgatg aggttaaatc 1641061 ttataagcgt ctccctctga ctctttatca aattcagtct aagttcagag atgaaaaacg 1641121 tcctcgcttc ggtttgttaa gaggccgcga atttattatg aaggatgcgt actctttcca 1641181 tgcatctgca gagagcctgg atgaaacgta tcaaaaaatg tacgaggcct attctaatat 1641241 ttttgcccgc tgcggcatta atgtaagacc tgttatcgct gattcaggcg caatgggagg 1641301 aaaggatacg cacgaattta tggcactttc tgcgatcgga gaggatacga ttgcgtattc 1641361 tgatgaatca cagtacgcgg ctaatatcga gatggctgaa gttcttcacc aggaagttcc 1641421 ttcagatgaa gagcctaaag ctctagagaa ggttcatacg cctaacgtga aaacaatcga 1641481 agaactgact gcgttcttac aggtttcggc tgaagcgtgc attaagtcag tattgtttaa 1641541 agctgatgac cgttttgtct tagtgcttgt aagaggggat catgaagtta acgatattaa 1641601 agtgaaaaac ttgcttcatg cagaagttgt agagcttgct acacatgaag aggtcattca 1641661 gcagctcgga acagagccag gctttgtagg ccctgtcggt attcatcagg atgtggaagt 1641721 atatgccgat caagctgtga aagcaatggt taatgctgtt gccggggcaa atgaaggaga 1641781 tcatcattat aaaaatgtca atgtgaatcg tgacgcgcaa attaaagaat ttgctgatct 1641841 tcgttttatt aaagaaggtg atccttcacc agacggcaag ggaacgatcc gttttgctga 1641901 gggaatcgaa gtcggacaag tctttaagct cggaacacgc tattcagaag cgatgaatgc 1641961 gacatattta gatgaaaacg gacgcgcgca gccaatgctg atgggctgtt acggaatcgg 1642021 tgtgtcaaga acgctttctg ctattgctga acagcatcac gacgaaaaag gcttaatatg 1642081 gccaaaaagc gttgcgccgt acgatcttca tattcttgct ttgaacatga aaaacgatgg 1642141 gcaaagagag cttgctgaaa agctgtatgc cgatttaaaa gcggaaggct atgaagtgct 1642201 ctatgatgac cgtgctgagc gtgccggcgt aaaattcgct gattcagatt taatcggcct 1642261 tccaatccgc atcactgtcg gaaaacgagc tgacgaagga atcgtcgaag tgaaaattcg 1642321 tcaaactggt gagtcaactg agatttcagt agacgaatta tctgcgttta tcagcaagca 1642381 gtaatcacca taacgattta tcaaaaaaca tgttaaaata gaaataatag aaggtacctc 1642441 attgcctgag gtaccttcac ttatgatgtt tttagggagg gatactgtct taatggaaca 1642501 gttatcagta aacagaaggc agtttcaaat tcttctgcag cagattaata tgacagatga 1642561 taccttcatg acatactttg aacatggcga gattaaaaag ctgacaattc acaaagcttc 1642621 taagtcttgg cattttcatt ttcaatttaa atctttgctg ccttttcaaa tatatgacac 1642681 attaacaacg aggctgacgc aatcgtttgc ccacatagca aaagtgacat cttcaattga 1642741 agttcaggat gccgaggtca gtgaaagtat cgttcaagac tactggtcac gctgcattga 1642801 agaactgcag ggcatttcgc cgccgattat cagtctttta aaccagcaaa aaccgaagct 1642861 gaagggcaat aaactgattg tcaaaaccaa aacagataca gaagcggctg cgctaaagaa 1642921 caaatacagt tccatgattc aagcagaata ccgtcaattt ggctttccgg atcttcagct 1642981 tgatgctgaa atatttgtat ccgagcaaga agttcaaaag tttcgggagc aaaagcttgc 1643041 ggaagaccaa gagcgggcta tgcaggcctt gattgaaatg gagaagaaag ataaagaaag 1643101 tgatgaagac caagcaccat ctggtcctct tgttatcggt tatcaaatta aagataacga 1643161 ggaaatccga acacttgaca gcatcatgga cgaagaacgg agaattacgg tccaaggtta 1643221 tgtgtttgat gtggagacgc gcgagctgaa gagcgggcgc acgctgtgta tcttcaaaat 1643281 tacagactat acaaatagta ttttgatcaa aatgtttgca cgtgaaaaag aagatgcggc 1643341 gctgatgaag tctctgaaaa aaggaatgtg ggtaaaagca cgcggaagca ttcaaaatga 1643401 tacatttgtc agagaccttg tcatgatcgc aaatgacgta aacgaaataa aagcaaaaac 1643461 ccgtgaagat tcagcacctg aaggagaaaa aagagtggaa ttgcatcttc attccccaat 1643521 gagccaaatg gatgctgtta cgggtatcgg aaagcttgtc gaacaggcga aaaaatgggg 1643581 gcatgaggcc atcgctttga ccgaccatgc tgtcgttcaa tccttccctg atgcgtattc 1643641 tgcggccaaa aagcatggaa ttaaaatgat ttacgggatg gaagcgaatc tcgtggatga 1643701 tggcgtgcca attgcttata atgccgcaca tcgtctgctc gaagaagaaa catatgttgt 1643761 ttttgacgtt gagacgacag gattgtctgc tgtatacgat accattattg agctggctgc 1643821 agtaaaagta aaaggcggag aaattattga taaatttgag gcgtttgcga acccgcatcg 1643881 tccgctttcc gccacaatca tagagctgac agggatcaca gatgatatgc tacaagacgc 1643941 tccggatgtc gtagatgtaa taagagattt cagagaatgg attggcgatg atattcttgt 1644001 cgctcataat gcaagctttg atatgggatt cttaaatgta gcctataaaa aacttcttga 1644061 agtcgaaaaa gctaaaaacc cagtcattga tacgcttgaa cttggacgtt ttctctatcc 1644121 ggaatttaag aaccaccggt tgaacacact ttgtaaaaag tttgatatcg agctcacaca 1644181 gcatcaccgt gcgatctatg atactgaggc aaccgcttat ttgcttctga aaatgctgaa 1644241 agacgcagct gaaaaaggta ttcagtacca tgatgagttg aatgaaaata tgggtcagtc 1644301 caatgcttat caaagatcaa gaccgtatca tgcaacatta cttgccgtga acagcacggg 1644361 acttaaaaat ttatttaagc ttgtgtcact ttctcatatt cattattttt acagagtgcc 1644421 gcgtattccg agatctcagc ttgagaaata cagggaaggg cttctgatcg gttctgcttg 1644481 tgacagggga gaggtttttg agggaatgat gcaaaaatcg cctgaagagg tggaagatat 1644541 cgcgtcattc tatgattacc ttgaggttca gccgcctgaa gtgtatcgtc acttgctgga 1644601 gcttgaactg gtccgtgatg aaaaagcgct gaaagaaatt attgcgaata tcacgaagct 1644661 gggggaaaag cttaataaac cggttgttgc tacgggaaat gttcattact tgaatgatga 1644721 ggataaaatc tacagaaaga ttttaatatc ctcacaaggc ggggcaaatc cgctgaatag 1644781 gcatgaactg ccgaaagtgc atttcagaac gacagacgaa atgcttgaag ctttttcttt 1644841 cttaggtgaa gaaaaagcga aggagatcgt agtcaccaat acccaaaagg ttgcttcttt 1644901 agttgatgac atcaagccga ttaaagatga tttatatacg ccgaaaatcg aaggcgctga 1644961 tgaagagatc agagaaatga gctatcagcg tgcaagaagc atttacgggg aagagctgcc 1645021 tgaaattgtc gaagcgcgga ttgaaaaaga gttaaagagt attattggcc acggatttgc 1645081 tgttatttac ttgatctctc acaaacttgt aaaacgttca ctagatgacg ggtatctcgt 1645141 tggttcccgt ggttccgtag gatcttcatt agttgcgaca cttactgaga ttactgaggt 1645201 aaacccgctg ccgccgcact atgtttgtcc tgagtgccag cattctgagt tctttaatga 1645261 cggttctgtc ggttctggtt ttgacctgcc tgacaagaca tgccctcatt gcggaacgcc 1645321 tttgaaaaaa gacggccatg atattccatt tgaaacgttc ttaggattta aaggggacaa 1645381 agtacctgat atcgatttga acttctcagg ggaatatcag ccgcaagcac acaattacac 1645441 aaaagtattg ttcggagaag acaatgtata tcgtgcggga acaataggca cggtggcaga 1645501 aaaaacagcc tacggttatg taaaaggcta tgccggagac aacaatcttc atatgcgcgg 1645561 tgccgaaata gatcggctcg tacagggatg cacaggtgta aaacgtacaa ctggacagca 1645621 ccctggcggt attatcgtag ttccggatta tatggatatt tatgattttt caccgatcca 1645681 gttcccggca gatgccacag gttcagagtg gaaaacgact cattttgatt tccactccat 1645741 ccatgacaac ctgttaaaac ttgatattct cggacacgat gacccgactg ttattcggat 1645801 gcttcaagac ttaagcggaa tagatccgaa aacaattccg acggatgatc ctgaagtgat 1645861 gaagatcttc cagggaaccg aatcactcgg tgtgactgaa gaacagattg gctgtaaaac 1645921 gggcactctt ggaattcctg aattcggaac ccgatttgtc cggcagatgc ttgaagatac 1645981 aaagccgacc actttttctg agctcgttca gatttcaggc ttgtctcacg gaactgatgt 1646041 atggcttggc aatgcacagg agctcatcca caataatatt tgtgagctga gtgaggttat 1646101 cggctgccgt gatgacatta tggtttattt aatctatcaa ggccttgagc cgtcccttgc 1646161 ctttaaaatc atggaattcg tgcgtaaagg aaaaggatta acgcctgaat gggaagaaga 1646221 aatgaaaaat aacaatgtcc cagactggta tattgattcc tgtaaaaaga ttaaatacat 1646281 gttcccgaaa gcccacgccg cggcatatgt cttaatggca gtccgcattg cttactttaa 1646341 agtgcatcat gctcttttgt attatgcggc ttattttacc gttcgtgcag atgactttga 1646401 tattgataca atgatcaagg gctctacagc aatcagagcg gtaatggagg atataaacgc 1646461 taaaggactt gatgcttcac cgaaggaaaa gaaccttctg actgttttag aattagcgct 1646521 tgagatgtgt gagagaggct attcattcca aaaagtcgat ttatatcgct ccagcgccac 1646581 agagtttatt attgacggca acagtcttat tccgccgttt aactctattc cagggttagg 1646641 gacgaacgct gctttgaaca ttgtaaaagc tcgcgaagaa ggcgaattcc tctcaaaaga 1646701 agatttgcaa aagagaggga aagtatcaaa aacgatttta gagtacttag atcgccatgg 1646761 ctgtctggag tcactgcctg atcaaaacca attgtcactg ttctaatatg gaaagcagaa 1646821 tttctcagaa attctgcttc tatgcataca taagcgcaaa aagtgccatc gtaatattag 1646881 agtttctgtc acttgcttag gtatgaaggt aagcgtatat ccatttgcaa taaaaatatg 1646941 gttatggtat agttttattg gaaatgctaa cgattaccga ggcaaagagt ggggaaaccc 1647001 gctcttttgt attgaacagg agaattttgt ctcgacatgt tcatcgttta ctttttagcc 1647061 cctgctcttt tgaagcaggg tttttatgca gagtgacgag acgaatatga gatcgacagc 1647121 acaaggagga agaacatgag caaaaaagtg actgacaccg ttcaagaaat ggctcagcca 1647181 atcgtagaca gccttcagct ggaactcgtt gacattgaat ttgtcaaaga gggccaaagc 1647241 tggttccttc gcgtgtttat tgattccgat gacggtgtgg atattgagga atgtgccaaa 1647301 gtaagcgaag ctttaagcga aaagcttgat gaggcagacc caatcagcca aaattacttt 1647361 cttgaagtct catctccagg agctgagcgt ccgctaaaga aaaaagccga tttcgaaaaa 1647421 tcactaggaa aaaacgtata cattaagacg tatgagccta ttgacggcgt aaaagtgttt 1647481 gaaggtgaac tggctgaatt tgatggacaa acagtgacag ttgagatcac gatcaaaaca 1647541 agaaagaaac ggatcaatat tccgtatgaa aagatagcta atgcaagatt agctgttaca 1647601 ttctaatgaa tacaaatgtt ttaagggggg agaccgttaa atgagcagtg aattattaga 1647661 tgctctcacg attcttgaaa aagaaaaagg catcagtaaa gaaattatca tcgaagcaat 1647721 cgaagctgcg ttaatttctg cttataagcg gaattttaat caagcgcaaa atgtacgggt 1647781 ggatctaaac cgtgaaactg gctccatccg tgtatttgca agaaaagatg tcgttgacga 1647841 agtatacgac cagagattag aaatctcaat tgaagaggca cagggcatcc atccggaata 1647901 tatggtcggc gatgtcgtcg aaatcgaagt tacacctaag gatttcgggc gcatagctgc 1647961 tcaaacagcg aagcaggtcg tcacacagcg tgtgcgcgaa gctgagcgcg gtgtgattta 1648021 ttctgaattt atcgaccgtg aagaagacat catgacaggg atcgtccagc gtctggacaa 1648081 taaatttatc tacgtgtctt taggcaaaat agaagccttg ctgccggtta atgagcaaat 1648141 gccgaatgaa agctacaagc cccatgaccg cattaaggta tatatcacaa aagtagaaaa 1648201 aacaacgaag ggtccgcaga tttatgtgtc aagaacacat ccaggcctgt taaagcgttt 1648261 gtttgaaatt gaagtgcctg aaatttatga tggaactgtc gagctaaaat ctgttgccag 1648321 agaagccggc gaccgttcga aaatttctgt tcgcacagat gatcctgacg ttgatcctgt 1648381 cggttcatgc gtagggccta aaggccagcg tgtgcaagca atcgtcaatg aattaaaagg 1648441 tgaaaaaatt gacattgtca actggtccag tgatcctgta gaatttgtcg cgaatgcgct 1648501 cagcccttcc aaagtgcttg atgtcattgt taatgaagaa gaaaaagcga caactgttat 1648561 tgttcctgat taccagctgt ctctggcaat tggaaaaaga ggacaaaacg cacgcttagc 1648621 tgctaaactg acaggctgga agattgatat taagagcgaa acggacgcaa gagaacttgg 1648681 aatctatccg agagaacttg aagaagatga tgagccgctc tttacggagc ctgaaactgc 1648741 tgaatcggat gaataagagg tgactttagg tgaataaaca caaaaagatc ccattacgca 1648801 aatgtgtagt gactggtgaa atgaagccta aaaaggaact gatccgagtt gtacggtcga 1648861 aagaaggcga aatctcagta gacccgaccg gaaaaaagaa tgggcggggt gcttatttaa 1648921 cgctggataa agagtgcatc ttagcagcaa aaaagaaaaa cactttgcaa aatcaatttc 1648981 aatcacaaat cgatgaccag attttcgatg aattgctgga actggcggaa aaggtgaaaa 1649041 aataaaatgt ctggaatgga atggtttccc ttgctgggtc tggccaatcg agctcgtaag 1649101 gtcgtgtcag gcgaagactt ggtaataaaa gaaatcagga atgcgcgtgc aaagcttgtc 1649161 ctgcttacag aggatgcatc atctaacaca gcaaaaaaag taactgacaa gtgcaattat 1649221 tataaagtcc cttataaaaa agtcgagagt cgcgcggttc ttggacgctc tatcggtaaa 1649281 gaagcccgtg tcgttgtcgc cgtcactgac caaggttttg cgaataagct gatcagcttg 1649341 ctcgattaat atttttgggg gtgaacgaat ggctaaaatg agagtatacg aatatgcaaa 1649401 agcgttaaat gtttcaagta aggaaatttt gaccgcactg aagaacatgg atttagaagt 1649461 gaataatcac atggccatgc ttgaagaaaa ggccattaaa aagctagatg ccaaatataa 1649521 aaaaggcggc gcagctgcta aatctcaaaa gccagcagaa acgaacaaaa acaaacagcc 1649581 acaaggggtt aatcagcaat cagctggaaa tcaaccaaat aaaattcgag acggaaagaa 1649641 gaatgacgtg cagaataatc aatttaacaa aaacaagaag aataacaaca acaaaaaaaa 1649701 taaacgcaac aacaacaata ataaaaacca acatcagcaa aagcctgtaa agccgaaaaa 1649761 agagcttcct gagaaaatta cattctctgg cactttaaca gttggcgcac ttgctgaaga 1649821 gcttggcaaa gagccttcag aactcattaa aaagctgatg cttcttggcg taatggcaac 1649881 cattaaccaa gagcttgata aagacacaat cgaactcatt gcatcagaat atggtgttga 1649941 aacagaagag gtcattgtgc ttgaagaaac agagctggaa aaatacgaag agcctgataa 1650001 tgaagaggat cttgaaattc gtcctcctgt cgtgacaatc atgggccacg ttgaccatgg 1650061 gaaaacaacg cttcttgaca gcatccgtaa aacaaaggtt gttgaagggg aagcaggcgg 1650121 aatcactcag catatcggcg cttatcaaat tgaagagaac ggcaagaaaa tcacgttctt 1650181 ggatacaccg ggccacgccg catttacaac aatgcgcgca cgcggtgcag aagtaactga 1650241 tattacgatt cttgtcgtag ctgccgatga cggtgtcatg ccgcaaacag ttgaagcgat 1650301 taaccatgca aaagcagcag aggttccaat catcgttgct gtgaataaaa tagataaaga 1650361 atccgcaaac cctgaccgtg taatgcaaga actgacggaa tacggacttg tccctgaagc 1650421 ttggggcgga gaaaccattt ttgtgccgct ttccgcttta actggaaaag gcattgatga 1650481 gctcgttgaa atgattttgc ttgtcagtga ggtagaggaa ctgaaagcga atccgaatcg 1650541 tcaggcaaaa ggaacggtta ttgaagctga actcgataaa ggcagagggt cagtcgcgac 1650601 gttgctcgta cagactggaa cactgcatgt cggtgatccg atcgtagtcg gcaatacatt 1650661 tggccgtgtc cgtgcaatgg tcaacgacat tggccgccgt gtgaaaactg ccggcccgtc 1650721 aactccggtt gaaattaccg gtttgaatga tgtccctcaa gcgggagacc aattccttgt 1650781 ctttaaggat gaaaaaacag ctcgttctgt cggtgaagcc cgtgcttcga aacagcttga 1650841 agagcagcgc agcgataaag cgaagctcag tcttgatgat ttatttgagc aaattaagca 1650901 aggtgatgta aaagacatca acctcatcgt aaaagctgac gttcaaggat ctgctgaagc 1650961 tttaacggct gcacttcaaa aaattgaagt agaaggcgtt aaagtgaaaa tcatccatac 1651021 aggcgttggt gcgattactg aatcagacat tatcttggca tctgcttcca atgcaattgt 1651081 tatcgggttt aatgtgagac cggacggaaa tgctaagagt acggctgaag ctgaaaatgt 1651141 agatattcga cttcaccgta tcatttacaa agtaatcgac gagattgaag ctgccatgaa 1651201 aggtatgctt gatcctgaat atgaagaaaa agtaattggt caagtagaag tacgccaaac 1651261 attcaaagta tctaaaatcg gtacaattgc cggcggatat gttactgaag gaaccattac 1651321 gcgcgacagc ggcctccgtt taattcgtga cggcgtcgtc atctttgaag gcgaagtaga 1651381 tgttctgaaa cgctttaaag acgatgtgaa agaagtttca caaggctatg aatgtggtat 1651441 tacaattaag aaatacaatg acattcgtga aggtgacatc cttgaagcgt ttgtcatgca 1651501 agaaattgaa agaacgtgat cggatttgcg gagtgtgaat gcatcattta tgatgcagga 1651561 tcgctaaaag aaaagcgtgc cgttctgaag cggattttaa ccagggttca aaacaagttc 1651621 aatgtttcga tttcggagat tggctatcag gacacctggc aaagaaccag cttcggaatc 1651681 gccgctgttt cttcctctcg cgttcaaaca gaaaaagaac tgcagcgcgt cctagcgttt 1651741 atcgattctt ttcctgaaat tgaacggacg atcactagga cagagtggtt ttaacttaga 1651801 ggtgattgaa ttgagtatga gagcaaaccg tgtcggcgag caaatgaaaa aagaactcgg 1651861 tgatattatc agccgcaagc tgaaagaccc gagaattggt tttctgacag taacggatgt 1651921 acgtgtatca ggtgatttgc aaattgcaaa ggtgtatatc tcggttctcg gtgacgagaa 1651981 aaaacgggaa gaagcgctga aagggctggc aaaagcgaaa ggatttatcc gatccgaaat 1652041 cggcagccgc atcagacttc gaaaaacgcc tgaaattgaa tttgagttcg atgaatcaat 1652101 cgattacggg aatcggatcg aaacactgat tcacgaatta cattcagaga aaccatctga 1652161 ataaaaaaag agaggatagg cgtatatcgt ctgtcctctt tcttcgttta taagaaaaaa 1652221 actcaaaaga aggagtgaaa ggcaaatggt taacggagtt ctccttttac ataaacctgt 1652281 tggcatgaca tcgcacgact gtgtcatgaa gatccgaaag ctgttaaaaa caaaaaaagt 1652341 aggacataca ggaacgctcg atccggaagt atcaggcgtg cttccgattt gtgtaggaag 1652401 agcgacaaaa atagtcgaat acttaactga aaaatctaaa acgtatgatg cagaaataac 1652461 attgggcttt tcaaccacaa cagaggatca aaccggagaa acggtggaaa caaagcctgt 1652521 caatcacgac attgataaag cggatgtaga aaaggtttta aacagtttaa aggggaaaca 1652581 agaacaaatt ccgcccatgt attccgctgt aaaagtaaac ggcaaaaaat tatacgaata 1652641 cgcaagagca gggattgaag tagaacgtcc gaaacgtatg ataaccattg aagacattgc 1652701 cctgacaaca gagattaaac atcatggaga aaccgcaagc ttccggttta cagtgacttg 1652761 ctccaaaggg acctatgtaa ggacgctggc ggtcatgatc ggagaaaagc tcggatatcc 1652821 ggcccatatg tctcatttaa tccgtacggc atccggagat ttttctctcg acgaatgctt 1652881 tacttttgat gaactcgaag cacaggccca atccggaacc gtggaagagc atacagttcc 1652941 tattgaacgt gcgctcaatc atttgccgaa atggatcata agtgatacat tagctaagaa 1653001 agtagaaaat ggggctttgc ttgagacgcc cgagcagttt tctgaaatga caagtggaga 1653061 ccgtattgcc gtctttactg aatccggaac ctgcttggcg atctatttcc ctcatcctgc 1653121 aaaaaaaggg ctgttaaagc cggcaaaagt attgatgcaa aaaagcgaac aatagaaaaa 1653181 aggtgaccgt tctgtgaaga cgatacatat tacacatcct catcatttaa taaaagagga 1653241 gcaggcaaaa tcagtgatgg cgttaggtta ttttgacggc gttcatctcg ggcatcaaaa 1653301 ggtaatcggc acagcgaagc aaatagccga agaaaaaggt ctgacattag ctgtgatgac 1653361 ctttcatccc catccttctc acgtgttggg cagagataag gaaccaaagg atctgattac 1653421 gcctcttgaa gacaaaataa accaaattga acaattaggc acagaagttc tgtatgtcgt 1653481 taaatttaat gaagtgtttg cttctctttc tcctaagcag tttatagacc agtatattat 1653541 cggccttaat gtgcagcacg cagtggcagg ctttgacttt acgtacggca aatacggcaa 1653601 gggaacaatg aagaccatgc cggatgattt agacggaaaa gctgggtgca caatggtaga 1653661 aaaattaacg gagcaggata aaaaaatcag ttcttcgtat atccgtaccg cgcttcaaaa 1653721 cggagatgtt gaattggcga atgtcttgct tggacaacct tattttatta aaggaattgt 1653781 cattcatggt gataaaagag ggcggaccat cgggtttccg acagcgaatg tcggtttaaa 1653841 taacagctat atcgttccgc ccacaggtgt atatgccgta aaagcggaag tgaacggcga 1653901 agtttacaat ggcgtttgca atattggcta taagccaacg ttttatgaaa agcgccctga 1653961 acagccttcc atcgaggtca atctgtttga tttcaatcaa gaggtatatg gagccgctat 1654021 aaaaatcgaa tggtacaaac ggattcggag cgagcggaaa ttcaatggca tcaaagaatt 1654081 aactgagcaa attgagaaag ataagcagga agccatccgt tatttcagca atttgcggaa 1654141 ataacttgca acgcacgcaa attttattct aaaatatttg catataggca cgatttttag 1654201 tatgatagtt ttcgtagtct taaaaccatt gcttggcaat ccgaagtcac cgacggttgc 1654261 taggtaactg gggctaaata tgatttggag gtgaaacagg atggcaatta ctcaagagcg 1654321 taaaaaccaa ctcatcaatg agttcaaaac acacgaatct gatactggat ctccagaagt 1654381 tcagatcgct atcctaactg actcaattaa caacttgaac gagcatttac gtactcacaa 1654441 gaaagaccac cactcacgtc gcggtcttct taaaatggta ggtaagcgtc gtaatcttct 1654501 tacgtatctg cgtaataaag acgtaactcg ttaccgtgag ttaattaaca aactaggctt 1654561 acgtcgataa tcgtaaaaag cgggaggatt cccgcttttt tatcgtatta aagcgaaatt 1654621 tcttataaca aatcattgaa atccttttac atactacttt gacattgata tgttcaattc 1654681 atttcgttca taataggagt aattgattat ttcacacaac gaagagagga gttcgtaatt 1654741 gtatgggaca agaaaaacat gtctttacca tagattgggc cggaagaacg cttaccgttg 1654801 aaaccggcca gcttgccaaa caggcaaatg gtgctgtgat gatccgctac ggtgatacag 1654861 cagtacttag tacagcaacc gcttcaaaag aacctaaacc gcttgatttc ttccctctta 1654921 ctgtaaacta tgaagaaaga ttatatgcgg tagggaaaat tccgggcgga tttattaaaa 1654981 gagaaggacg tccaagtgaa aaagcggttc ttgccagccg tttaattgac cgtccgatcc 1655041 gtcctttgtt tgccgatgga ttccgtaatg aagttcaagt catcagcatt gtcatgagtg 1655101 ttgaccaaaa ctgctcttca gaaatggctg ccatgttcgg ttcatctctt gcactttctg 1655161 tatcggatat tccgtttgaa ggaccgattg caggggttac tgtcggacgc attgatgatc 1655221 aatttatcat taacccgaca gtcgatcagc ttgaaaaaag cgatatcaat cttgtcgttg 1655281 ccggcacgaa agatgcgatt aacatggtag aagcgggagc ggacgaagtt cctgaggaaa 1655341 tcatgcttga ggccattatg ttcggccatg aagagattaa acgcctgatt gcattccaag 1655401 aagaaattgt tgcagcagtc ggcaaagaga aatctgaaat taagctcttt gaaattgatg 1655461 aagagcttaa tgaaaaagta aaagctttgg cagaagagga tctgctgaaa gccatccaag 1655521 ttcatgaaaa gcatgcccgt gaagatgcca ttaacgaagt gaagaacgca gttgtggcaa 1655581 aattcgagga tgaagaacat gatgaagaca caatcaagca agtgaagcag attttatcca 1655641 agcttgtgaa aaatgaagtt cgccgcctga ttactgaaga gaaagtaaga ccggacggcc 1655701 gcggtgtcga tcaaatccgt ccgctctctt cagaggttgg cctcttgcca agaacgcacg 1655761 gttcaggtct atttacaagg ggacaaactc aggccctcag cgtatgtacg ctaggtgctc 1655821 tgggagatgt gcaaatcctt gacggcttag gtgtcgaaga gtcgaaacgg tttatgcatc 1655881 attacaactt cccgcaattc agcgttgggg aaacaggacc gatgcgcgga ccgggacgtc 1655941 gtgaaatcgg acacggagca ctgggtgagc gtgcgcttga gccagttatt ccgtctgaaa 1656001 aagacttccc ttatactgtc cgtcttgttt cagaagtgct tgaatcaaac ggttctacat 1656061 ctcaagcaag catttgcgca agcacacttg caatgatgga tgccggtgta ccgattaaag 1656121 cgccagttgc tggtattgcg atgggtcttg tcaaatcagg cgaacattac actgtcttga 1656181 ctgacatcca aggcatggaa gacgcgctcg gagatatgga ctttaaagta gcgggaactg 1656241 aaaaaggcgt aacggccctg caaatggaca ttaaaattga aggcctttcc agagagattc 1656301 ttgaagaagc gcttcagcag gcgaaaaagg gcagaatgga aatcctcaac agcatgcttg 1656361 caacattaag cgaatcaaga aaagagcttt ctcgatatgc gcctaagatc ttaacaatga 1656421 ccattaatcc tgataaaatc cgcgatgtca tcggaccaag cgggaaacaa atcaataaga 1656481 tcatcgaaga aaccggtgtt aaaattgata ttgagcagga cggcacaatc tttatttcct 1656541 ctacagatga aagcggcaac caaaaagcga aaaaaatcat cgaagacctt gtgagagagg 1656601 ttgaagtcgg ccaactttac ctaggtaaag tgaaacggat tgaaaaattc ggggctttcg 1656661 ttgaaatttt cagcggaaaa gacggtttgg tgcacatttc agagcttgcg cttgaacgcg 1656721 tagggaaagt tgaagatgtt gtgaaaatcg gagacgagat tcttgtcaaa gtcactgaaa 1656781 ttgataaaca aggacgagtg aatttatccc gcaaagcggt gctccgtgaa gagaaagaaa 1656841 aagaagaaca acaatcttaa atgaaaacat aaaaggagcc tgggagaccc ggcttcttta 1656901 ttttgaagct tttcaaaagc aggcgggttc taccttgtcc ttctccttca taatgtgagg 1656961 tgaggggggg acagaacatg tacaaaaaat ttgtaccgtt tgccgttttt ttatttcttt 1657021 tttttgtctc atttgagatg atggaaaatc cgcatgcact tgattatata ggggcaatga 1657081 aaaaagatac ggtgactgtc acggcgtcaa aagacccgtt atatgaagaa ttgcttcaaa 1657141 aagcgccgga gtacgaagtt aagccccaga atgcaagaat tgataaagtg tggaaaagca 1657201 ttccaggcta caatggatta aaggtcaata ttgaacaatc atataaaaaa atgaaacagc 1657261 atggtaagtt tcgggaaaaa gatttggtgt acagtcaagt aaaaccaagt gttcatcttg 1657321 agtcacttca gcctgagcct atttataaag gaaatcctga caaaccgatg gtggcttttt 1657381 taatcaatgt ggcatgggga aatgagtatt tggaaaaaat gcttcctatt ctgcaaaagc 1657441 accaggttaa agctacgttc tttttagaag gcaattgggt gagaaacaat gtacagctcg 1657501 ctaagaagat tgcaaaagac ggacatgaaa tcggaaatca ttcatacaat catccggata 1657561 tgagcaaact gactacagga agaatttccg agcagctcga caagactaat gaacaaatag 1657621 aacaaacgat cggcgttaag ccaaagtggt tcgctccgcc aagcggaagt ttcagaaaag 1657681 cggttatcga cattgcagca gagaaacaga tgggaacagt catgtggaca gttgatacaa 1657741 tcgattggca aaagccggct ccgtctgtac ttcagacgag agtgttaagc aagatacata 1657801 atggtgccat gattttaatg catccgactg accctacggc ggaaagtctt gaagcgctga 1657861 ttacacagat aaaagacaaa ggatatgcgc ttggaacagt cactgaacta atggatgaaa 1657921 caagactatt gaagtaacag atgaaggcag cttgtctttg aataggagga acaaatttga 1657981 ttaaacgata tacgtgtcaa aatggtgtaa gaattgtgct ggaaaataac ccgacagtcc 1658041 gttctgttgc gatcggcgta tggatcggca caggttcgag acatgaaacg ccggagataa 1658101 acggaatttc tcacttttta gagcacatgt tctttaaagg gacgagcaca aaatctgcac 1658161 gcgagatagc agaatctttt gatcgtattg gcggccaggt caatgcgttt acttcaaagg 1658221 aatatacctg ctactatgca aaggtgcttg acgagcatgc gaattacgcg ctggacgtat 1658281 tagcagatat gttctttcat tcaacgtttg atgaaaacga gctgaaaaaa gagaaaaatg 1658341 tagtatatga agaaattaaa atgtatgaag atgcgccgga cgacattgta catgatttat 1658401 tgagcaaagc cacttacggc aatcattctt taggctaccc aattttagga acggaagaaa 1658461 cgcttgcttc ctttaacggt gactctctca gacaatacat gcatgattat tatacgccgg 1658521 accgagtggt gatttcggta gcgggcaata tatctgacag ttttatcaaa gatgtagaaa 1658581 aatggttcgg gtcatacgag gcgaaaggca aagcgacagg ccttgagaag cctgagttcc 1658641 acacggaaaa actgacgaga aaaaaagaaa cagagcaggc tcatttgtgc cttggattta 1658701 aaggcttaga ggttggccat gaacgtattt atgatttaat cgtcctcaac aatgtgctcg 1658761 gaggcagcat gagcagccgg ctgttccaag atgtgcgtga agataaagga cttgcttatt 1658821 ctgtttacag ctatcacagc tcatatgagg acagcggaat gctaacgatt tacggcggaa 1658881 cgggtgcaaa tcagcttcag cagctgtcgg aaacaattca agaaaccctg gccacattaa 1658941 aacgtgacgg cattacctcg aaagaactgg aaaacagcaa agagcaaatg aagggaagct 1659001 taatgctgag cttagaaagc acaaacagca aaatgagccg aaacggaaaa aatgaactgc 1659061 tgctcggcaa acataaaaca ttagatgaaa ttatcaatga attaaacgcc gtgaacttag 1659121 agcgtgttaa tggccttgcc agacaattgt ttaccgaaga ctatgcatta gcacttatca 1659181 gcccttccgg caatatgccg tcttaaaaag gaaagcctgc cccataatgg agcaggcatt 1659241 ttttaatccc tttcatcata catagtacaa gggggtgaca gacatgcggc tcagtgaatt 1659301 atcgggaaag gaaattgtag acatcaaaag agctgaacgg ctcggagtgc tcggccagac 1659361 cgatttggaa atcaatgaac aggatggaca gattacagca ctcctcattc ccacagttaa 1659421 gtggtttggt ttgagaaagc aaggtcatga cattcgtgtc ccatggcacc atattcaaaa 1659481 gatcggttca gatatgatta tattagatgt acctgaggaa atgcctcctc gacaagagta 1659541 aatagcccaa ttgactgtga agcgggctct aaagaaaaca tctgaaacat cggctgccgg 1659601 agccgatgtt tttttatatg gaaaaagcgc atcttttata ttcaccggta tttccttttg 1659661 atcataagat gaaggggagc ttaacaacta gagatccagt atatacaaag aaggtgaacg 1659721 tttagaatgt taaccggatt gaaaattgca gttatcggcg gtgacgcaag acagctcgaa 1659781 attataagaa agctcactga acagcaggct gacatctatc ttgtcggttt tgaccaattg 1659841 gatcacggtt ttaccggggc agtaaaatgc aatattgatg aaattccttt tcagcaaata 1659901 gacagcatca ttcttccagt atccgcgaca acaggagaag gtgtcgtatc gactgtattt 1659961 tcgaatgaag aagttgtgtt aaaacaggac catcttgaca gaacgcctgc acattgtgtc 1660021 attttctcag gaatttctaa cgcctattta gaaaacattg cagctcaggc aaaaagaaaa 1660081 cttgttaagc tgtttgagcg ggatgacatt gcgatataca actctattcc gacagtagaa 1660141 ggaacgatca tgctggctat tcagcacacg gattatacga tacacggatc acaggtggcc 1660201 gttctcggtc tggggcgcac cgggatgacg attgcccgta catttgccgc gctcggggcg 1660261 aatgtaaaag tgggggcaag aagttcagcg catctggcac gtatcactga aatggggctc 1660321 gttccttttc ataccgatga gctgaaagag catgtaaaag atatagatat ttgcattaat 1660381 accataccga gtatgatttt aaatcaaacg gtactttcta gcatgacacc aaaaacctta 1660441 atattggatc tggcctcacg tcccggggga acggatttta aatatgccga gaaacaaggg 1660501 attaaagcac ttcttgctcc cgggcttcca gggattgtcg ctcctaaaac agctgggcaa 1660561 atccttgcaa acgtcttgag caagcttttg gctgaaatac aagctgagga ggggaaataa 1660621 ggatgtcgtc attaaaagga aaaagaatcg ggtttgggct gaccgggtcg cattgcacat 1660681 atgaagcggt tttcccgcaa attgaggagt tggtcaacga aggagctgaa gtccgtccgg 1660741 ttgtcacatt taatgtaaaa tctacaaata cccgatttgg agagggcgca gaatgggtta 1660801 aaaaaattga agacctgact ggatatgagg ccattgattc gattgtaaag gcagaacctc 1660861 ttgggccgaa gctgcccctt gactgcatgg tcattgcgcc tttaacaggc aattcaatga 1660921 gcaagctggc aaatgccatg acggacagcc cggtgctgat ggcggcaaaa gcgacaatcc 1660981 ggaacaatcg gcctgtcgtt ctgggtatct cgacaaatga tgctcttggt ttaaacggaa 1661041 caaatttaat gaggctcatg tcaacaaaaa atatcttttt tattccattc gggcaagatg 1661101 atccatttaa aaaaccgaat tcaatggtag ccaaaatgga tctgcttccg caaacgattg 1661161 aaaaggcact catgcaccag cagcttcagc cgattctagt tgagaattat cagggaaatg 1661221 actaaattta cagaaaatct ttcccaaact aaaaaattcg gtcatcaccc gcatattcta 1661281 tggtaaaata aaacgtaaaa tcatagtcaa atcaattcaa tgaagctgat tggcggaagg 1661341 agttttacag atgggaagag gtttacacgt agctgttgtc ggagcgacag gggctgtggg 1661401 acaacaaatg cttaaaacac ttgaagacag aaactttgaa atggacacac ttacattgct 1661461 atcttcaaaa cgctctgcgg ggacaaaagt cacgtttaaa ggccaagagc tgactgttca 1661521 ggaagcttct cctgagagct ttgaaggggt aaatattgct ttgttcagcg ccggcggaag 1661581 cgtatcacaa gcattggcac cagaagctgt aaaacgcggc gctattgtta tagataatac 1661641 gagtgcgttc cgcatggatg aaaatacacc gcttgttgtg ccagaagtga atgaggcaga 1661701 cttgcatgaa cacaacggca ttattgccaa tccaaactgc tctacaatcc aaatggttgc 1661761 ggcacttgaa ccgatccgca aagcatatgg cttaaacaag gtcatcgtat caacttacca 1661821 ggcagtatca ggagcgggta atgaagctgt aaaagagctt tacagccaaa cacaggcgat 1661881 tttaaataaa gaagaaatag agcctgagat catgcctgta aaaggtgaca aaaaacacta 1661941 tcaaatcgcc ttcaacgcga ttccgcaaat cgataaattc caagataacg gctatacgtt 1662001 tgaggaaatg aaaatgataa atgaaacgaa aaaaatcatg cacatgcctg accttcaagt 1662061 agcggctaca tgtgtgagac tgccaatcca aactgggcac tcagagtccg tctacatcga 1662121 aatagaccgt gatgacgcta cagttgaaga tattaaaaat ctattgaaag aagctccggg 1662181 cgtgacactt caggatgatc caagccagca gctttatccg atgcctgctg atgctgtcgg 1662241 caaaaacgat gtgtttgtag gccgcatccg caaagacttg gacagagcaa acggttttca 1662301 tttatgggtt gtttctgata acctattaaa aggcgcggca tggaactctg ttcaaattgc 1662361 agaaagcctg aaaaaactaa acctcgtata aaagagagaa ttttctaaag acgaatagaa 1662421 gagagtaagg cgctatcagc ctgctctctt ctgttacgtc cgaataattt ggagtgaaaa 1662481 cagtgaagat aattgttcaa aagttcggcg gaacatcagt aaaagatgat aaaggccgca 1662541 aactggcttt agggcatatt aaagaagcaa tcagtgaagg atataaggtt gtcgttgtcg 1662601 tttcagcgat gggccgaaaa ggggacccgt atgcaacaga ttctttgctc gggctgcttt 1662661 acggcgatca gtcagcgatt tctcctaggg agcaggattt gcttttatct tgcggagaga 1662721 ctatttcctc tgtcgtcttt acaagcatgc tgcttgataa cggtgtgaaa gcagctgcgc 1662781 tgacaggggc tcaggctggc tttttaacga atgatcagca tactaatgcg aaaatcattg 1662841 aaatgaaacc ggagcgttta ttcagtgtgc tcgccaatca tgatgcggta gtcgtcgcag 1662901 gcttccaggg cgcaactgaa aagggtgata caacaacaat cggcagaggg ggcagcgata 1662961 cgtctgcagc cgcactcgga gcagctgttg atgcggaata catcgatatt ttcaccgatg 1663021 tagaaggcgt gatgactgct gacccaagag tggtagaaaa tgcaaaaccg cttcctgttg 1663081 tgacgtatac ggaaatctgc aacctggcgt atcagggggc caaggtcatt tctccgcgtg 1663141 ctgtggaaat cgcaatgcag gccaaggttc cgatccgcgt ccgttcgact tattcgaatg 1663201 ataaaggcac attggtgaca tcacatcact cttccaaggt cggcagtgat gtttttgaaa 1663261 ggctgattac gggaatcgcc catgtcaaag atgtcacgca gttcaaagtg cctgcgaaaa 1663321 tcggccagta taacgttcag actgaagtgt tcaaggctat ggcaaacgct ggaatcagtg 1663381 tcgatttctt taacattaca cctagtgaaa tcgtctatac ggtagccgga aataaaacag 1663441 aaacagctca gcgtatttta atggatatgg gctatgatcc aatggtgacg agaaactgcg 1663501 cgaaggtatc ggcggtcggc gcgggcatta tgggtgttcc cggtgttacg tccaaaattg 1663561 tatcggctct ttcagaaaaa gaaattccga tccttcagtc ggctgacagc catacgacga 1663621 tatgggtgct cgtccatgaa gcggatatgg ttcctgctgt aaacgctttg catgaagtgt 1663681 ttgaactttc gaagtaaatg tgattgaatc atgatgaggt gaataaaatg aatttcggaa 1663741 atgtgtctac agcgatgatt acaccctttg acaataaagg gaacgtagac tttcaaaaac 1663801 tgtctacact gattgattac ttgttgaaaa acggaacgga ttctttagta gtagcgggaa 1663861 caactggaga atctccgacc ctttcaactg aagaaaaaat tgcgcttttt gaatatacgg 1663921 taaaagaagt aaacggacgg gtgcccgtta tcgctggtac tgggagcaac aacacgaaag 1663981 attccattaa gctgacaaaa aaagctgagg aagcgggcgt ggacgctgtt atgcttgtta 1664041 ccccgtatta caataaacct tctcaagaag gaatgtacca gcattttaaa gcaattgcgg 1664101 cagagacatc tcttccggtt atgctctata atgttcctgg ccgtacggtt gcttctcttg 1664161 ctcctgaaac gacgatccgt ttggcggcag acattccgaa tgtggttgcg attaaagaag 1664221 cgagcggaga cctcgaagcg attacaaaaa ttattgctga aacacctgaa gacttctatg 1664281 tctattcagg ggatgatgct ctaacgcttc caattctttc agttggaggt agaggagttg 1664341 tgtcagtggc gagccatatt gcaggcactg atatgcagca aatgatcaaa aattatacga 1664401 atgggcaaac agctaatgcg gcactgattc atcagaaact gctgccgatt atgaaggaac 1664461 tgtttaaagc gcctaatcct gctccagtca aaacagcgct tcagctgaga ggtcttgatg 1664521 tcggttctgt gcgtctgcct ctagtcccat taactgagga tgaacgtctg agcttaagca 1664581 gcacgatcag cgaactgtaa gaaaatttca tacagtgaaa caaacgcggt cattctcaca 1664641 ttcagctgag tttgaccgtt tcttttacat attggttttc cctaaacctt ctgctttatc 1664701 ttgttttcta aatttacttt cagttataat aggaacaagt gatgatggac gggtatgaga 1664761 ctaggaggat atagattttg aaaaagaaaa atacagaaaa cgttagaatt atcgcccttg 1664821 gcggtgtcgg agagattggg aagaaccttt atgtcattga aattgactca gacatatttg 1664881 tcgttgatgc cggccttatg catccagaaa acgaaatgct cggtattgat gtagtgattc 1664941 ctgacatatc atatttgatt gaacgggctg accgcgtcaa ggcaatcttt ttaacgcacg 1665001 ggcacgatga aaatatcggc ggcgtttttt acttattaaa caagctgtcc gttccagtgt 1665061 acggaacaaa actgacgctt gcactgttaa gagagaaatt aaaacaatac ggacataacc 1665121 gaaaaactga tttaagagaa attcactcca aatctgtcat tacatttgaa tcaacaaagg 1665181 tatcgttctt tagaacgatt cacagcattc ctgattctgt aggtgtgagc tttaaaacat 1665241 cacttggatc tattgtatgc acgggagact tcaaatttga ccaaacacct gcacttaatc 1665301 agacgtgcga cattggcgag atcgccaaga tcggcaatag cggcgtgctc gctctgcttt 1665361 ctgacagtgc aaatgcggaa cggccgggtt acaccccttc ggaagcggct gtcagcggag 1665421 aaatttcgga tgcgctgtat aattcacaga accgggtgat tattgctgtt ttcgcatcca 1665481 atattaaccg gattcagcaa gtcattcatg cagcggctca aaatggcaga aagattgccg 1665541 tagccggaaa aaatcttcaa tctgtcctgc agctggcgag aaagttagga tatattgaag 1665601 cagatgatga attgtttatt tctgtacagg atgtcaaaaa atatccgaag cgcgaagtgg 1665661 ccattattac agccggaagc caaggtgaac cattagctgc tttgacaaga atggcaaaca 1665721 aagctcacaa acagctgaac attgaagaag gggatacggt ggtcattgcg tcaactccga 1665781 ttcccgggca ggaactcatt tactctaaaa cagtagatct tcttgcgaga gccggtgcac 1665841 aagtcatctt tgcccaaaag cgtgttcatg tatcaggcca cggctcacaa gaagagttaa 1665901 agctgatgat caacctgctt aaaccaaaat atttgattcc tgtaaacggc gaatacagaa 1665961 tgcaaaaagc tcattcaaaa atcgctgaag aaaccggcat gaagcgcagt gacatcttct 1666021 taattgaaaa aggcgacgtc gttgaattcc gcggccaaaa cgtaaaaatt ggggataaag 1666081 ttccttacgg caatatttta attgatggtt taggtgtcgg tgatatcggc aatatcgtat 1666141 tgagagaccg ccgcttgctt tcacaggacg gaattttaat cgttgtcatt acacttgata 1666201 aacaaaagaa acatcttgta tcaggaccag aaattatcac tcgcggcttt gtttatgtaa 1666261 gagagtctga aggtcttatc gtacaggcta ctgagcttgt acggtccatc gtgacagaag 1666321 cgactgaaac atcaaatgtc gaatggtcaa cgctgaagca ggcaatgcgg gatgctttga 1666381 accaattcct ttatgaaaaa acgaaacgta aaccgatgat catcccaatt attatggaag 1666441 tataatgact gactaaagac cggagctgct ccggtcttta ttttttgtcc ttcaagccgg 1666501 gattgaatga agtatctttg ttcataatac aaagagaaac tcggaaagga tgaaagcgag 1666561 atggatcatc gtatggaaaa cacagaagaa gagcgtcctg aaaaaaatga tgcgaaggac 1666621 agcattatga ataaaataca gcagcttggt gaaacgacgc ttccgcagct gccccaagat 1666681 acaaatattc attgtctgac cattatcgga caaattgaag gccatgttca gcttcctccg 1666741 caaaacaaaa caacaaaata tgaacatgtc atcccgcaga ttgtggcaat tgaacaaaat 1666801 cccaaaattg aaggcttgct gatcatatta aatactgtcg gaggagatgt tgaagctggt 1666861 cttgccatag cggaaatgct tgcatcttta tcgaaaccga ccgtttctat cgtgcttggc 1666921 ggggggcatt caatcggcgt tccgattgct gtatcctgtg attacagcta tatcgccgaa 1666981 acagcaacga tgacgattca tccagttagg ctcaccgggc tggtcatcgg ggtgccgcaa 1667041 acgtttgaat acctggataa gatgcaagaa agagttgtta aatttgtgac aagccattcc 1667101 aatataaccg aagagaagtt taaagagcta atgttttcaa aaggaaactt aacacgcgat 1667161 atcggaacaa atgtagtcgg taaggatgca gttaaatacg gattgatcga tcacgcaggc 1667221 ggtgtcggac aggcaatcaa taaactgaat gagctcatcg atgaagcaag gaaagaagaa 1667281 ggacggatga ttcaatgatt ctttataccg tgatgcctca ggaaattgtg tttgcagaac 1667341 agaaccaaga gacaagcgca catgagcaaa ttgaatataa aggtgtaccg cttctagtcg 1667401 aaatgaaagg gaatgaagcg gaagtcattc aaatcatgag caccaatcca atgcattttc 1667461 tgcatccgga catttcaccg ggacaaaagc tgaaattaaa cgtataagaa tccaaccctt 1667521 ttttaagggc aaaatatgct ataatagggg aatcctacag aaaaaacgca gcctgtaaac 1667581 ggctgctttc ttcattatgt atgaacttac attttttaac gcagtaaggt gatgagtgtg 1667641 gcaaagaaaa aacgaaaatc aagaaaaaaa caggcgaaac agctcaatat aaaatacgag 1667701 ctcaacggat tgctgtgtat agccatttca attatcgcaa tcttgcagct gggggtagtc 1667761 gggcaaacgt ttatctattt gttccgcttt tttgctggag agtggtttat tttatgcttg 1667821 ttaggtttat tggtgttagg agtctcactg ttttggaaga aaaaaacccc aagcctttta 1667881 acgagacgaa aggccgggtt gtactgtatt atcgcaagca tattgctgct ttctcacgtg 1667941 cagctattta aaaatttgac gcacaaaggg tctattgagt ctgcaagcgt ggtgcgcaat 1668001 acgtgggaat tgtttttaat ggacatgaat ggcagctctg cttcacctga tttaggcgga 1668061 gggatgatcg gtgcgctgct gtttgcggct tcacactttt tgtttgcgtc gactggttct 1668121 cagatcatgg caattgtcat gattttgatc ggaatgattt tagtaacagg acgctcgctg 1668181 caagaaacgc taaaaaagtg gatgagcccg attggacgtt ttataaaaga acaatggtta 1668241 gcatttattg atgacatgaa atccttcaaa tcaaatatgc agtcatcgaa aaaaacgaaa 1668301 gcgccgagca aaaaacaaaa accggcccgc aaaaaacagc aaatggaacc ggagcctcct 1668361 gatgaagagg gggattatga aacagtatcg cctcttattc attcagagcc gattatctca 1668421 agcttttctg atcgtaatga agaggaagag tctccagtta tagaaaagcg cgccgaacct 1668481 gtgtcgaagc cgcttcagga catccaaccg gagacaggtg atcaggaaac tgtttctgct 1668541 cctcctatga cctttacaga gctcgaaaat aaggattacg agatgccgtc actggatttg 1668601 ctggcagatc cgaagcatac cggccagcag gctgataaaa agaatattta tgaaaatgcg 1668661 agaaagcttg aacgcacatt ccaaagcttt ggcgtaaagg cgaaagtcac acaggttcat 1668721 ctcggaccgg ccgtaacaaa atatgaagta tatcctgatg tcggagtgaa ggttagcaaa 1668781 attgtcaatt taagcgatga tttagcgctt gcgcttgctg cgaaggatat caggatcgaa 1668841 gcgcctatac caggcaaatc agcaatcgga attgaagttc caaacgcaga agtggcaatg 1668901 gtttcgctga aagaagtgct ggagtctaaa ttgaatgaca gaccggatgc gaagctgtta 1668961 attggactcg gccgcaatat ttcaggtgaa gctgtattgg ctgagttaaa caagatgccc 1669021 caccttttgg tcgcaggcgc aaccggtagc gggaaaagtg tctgtgtcaa cggcattatt 1669081 acaagtattt taatgcgggc gaaaccgcat gaagtgaaaa tgatgatgat cgatcctaaa 1669141 atggtagagc taaatgtcta caacgggatt ccgcatttgc ttgctcctgt tgtaaccgat 1669201 ccgaaaaaag cgtcgcaggc tttgaaaaag gttgtcaatg aaatggagcg gcggtacgaa 1669261 ttattttctc atacgggtac aagaaatatt gaaggataca atgattatat aaaacgcgcc 1669321 aacaatgaag aaggagcgaa acagccagag ctgccttata ttgttgtcat tgtggacgag 1669381 ctagccgatc tcatgatggt cgcttcatct gatgtggaag attcgattac gagattgtcc 1669441 caaatggcgc gggctgccgg catccatctt attattgcga cacagcggcc atcggtggat 1669501 gttatcacag gggtgatcaa agcgaacatt ccgtcacgaa tcgcgttcag cgtatcttca 1669561 cagacggatt caaggaccat tcttgacatg ggtggcgctg agaagcttct tggccgcggc 1669621 gatatgctgt ttttacctgt aggggctaac aaacctgtcc gtgtgcaggg agcatttttg 1669681 tcggatgacg aagtggagaa ggtcgtcgac catgtgatta ctcagcagaa agcgcaatat 1669741 caagaagaaa tgattcctga ggagacgacg gaaactcatt ccgaggttac tgatgaactt 1669801 tatgatgaag ctgttgaatt aatcgtcggc atgcagacgg catctgtttc aatgctgcaa 1669861 agaagattca gaattggcta tacgagagcg gcgcgcctga ttgacgcaat ggaggaacgc 1669921 ggtgttgtcg gaccgtatga aggcagcaaa cctagggaag tattattatc aaaagagaaa 1669981 tatgatgagc tctcttctta atgaagggag ttccgctttc tatagttgtc aataatgata 1670041 ttatgtaaac tgatcacctt tctatttatt ttttcgacaa aacatgatat agttgtccca 1670101 attgttcaat aatttttatc gaaagtggtt tacggagggg aaacatgtct acaaaagctg 1670161 ataatcggca cttgtatttg aaagtaattg aacgaattaa agaggatata aaaaatggga 1670221 tctacactga gaaggaaaag ctgccttctg aatttgagct ttccaaaaag cttggtgtca 1670281 gcagagcgac gctaagagaa gccttgcgga tactggaaga agagcatgtg attatcagaa 1670341 ggcatggtgt aggcactttt gtccattcta agccgttatt tctttcgggt attgaacagc 1670401 tgaacagtgt aaccaagatg atagaacagg cgaatatgac ccctggcacg atttttctat 1670461 catcacaagt gcttatgccg tctgaagatg atacgaagag atttcacttg gcagaagggc 1670521 aagaactttt ttaccttgaa cgagtcagga cagctgacgg acagccgatt gtgtattgta 1670581 tagacaaaat tccgatgaat attttgccga attctttttc tcatcagcaa gaatctatgt 1670641 ttgacctgct agagaaaaat tcaggctccg taatcagcta tgcagtaact gatatagaac 1670701 cgatcggcta tcacgatacc atttctccag tgcttgaatg cgatccggaa acagctcttt 1670761 tgctgttaaa acaaacccat tacgatcagc acgataaacc ggtgctttat tctttaaatt 1670821 attttagagc ggataaattc agatttcatg ttttgcgtaa acgattctaa aaacggacgc 1670881 ctgtatgtgt ctgttttttt atttgcactg attcatgttt ctttgtacat actttcattc 1670941 cggttaacgc aatatataag ggatgacaag aaagtgaatg ggtgaaaatg ttgagagaga 1671001 aaaatggaat gaaaaatatt attgcattgt cttctgtccc gcttgtgatg acactcggga 1671061 actccatgct gattcctgtt cttccgatga tggagaaaaa gctgtctgtg acttcatttc 1671121 aagtatcttt aatcattact gtatattcag tagtagcaat tatttgcatt ccgattgccg 1671181 gatatttgtc ggatcgtttc gggagaaaaa aaatattgct tccatgcctc ctcattgcag 1671241 gattgggggg agccgtagct gcttttgcct cgacctatat gaaaaatcct tatgctatga 1671301 tcttggcggg gcgggttctt caaggcattg gttctgcagg tgccgctccg attgtcatgc 1671361 cgtttatcgg cgacctgttt aaaggagacg atgaaaaggt cagcgcgggt cttggcgata 1671421 ttgaaaccgc caacacgtca gggaaggtac tgagtcccat acttggagcc ttactggctt 1671481 cttggtattg gtttgtaccg ttttggttta ttccgttttt ctgtttgatc agctttttgc 1671541 tcgtattgtt tttggtggcc aagcctgaag aagatgaaga tgcgcctgct gtttctgagt 1671601 ttattaagag tgtgaagaaa atttttaaac aggatggtcg ctggctttat acggtcttca 1671661 ttatcgggtg tgtcattatg tttttgttat ttggcgtatt attttattta tcagatacgc 1671721 tggagaacaa gtatgctatt gacggagtag ctaaaggcgg attactggca atcccacttt 1671781 tgtttttgtc aaccagttct tttatagctg gcaaaaagat cggtaaagat aaaggccgaa 1671841 tgaaattttg cgttgttaca ggaatgattc tgttaaccct ttcgtttatt gccttgtggt 1671901 ggaaccacag tttttatttt ttatttgtct ttttaagctt tggcgggatt gggattggaa 1671961 tggctcttcc tgctttagat gcattgataa ccgaagggat tgaaagtgaa caatgcggaa 1672021 ccatttcctc cttttacaat agcatgcgct ttataggagt agctctcggt ccacctgttt 1672081 ttgctgcatt aatgtctaat gcaaactgga ttattttcat actctcggcg ttttgcagca 1672141 tcgtttcttt atttttagtg ctctttactg tagatgctaa aaaaagtgaa gaagaaaaaa 1672201 acttagggac ggtctagcca gccgtctttt tttgcgcttt cttgcacagt ttacaactgt 1672261 acctatacag catgcggagg ttattgtttc cttataaatc ctacagttgc tataattaca 1672321 tgaaagagtg tttctgcgga tgctgaaaat tggtcataat acatactaat taagaaatga 1672381 acgaaggagg ttccatatgt catatgttaa tgaactcaaa tcaaagcacg gcggtttaac 1672441 cgcacacatt gtaaaaacag aaaaattcaa aaccgtctcg cttattttta agatgcttgc 1672501 gccgctgaca aaggatcaag tcaccaaaag agcgcttctc ccgcatgtgc ttcttcgcgg 1672561 aacgaaaagc catccgaaaa ccgcaggatt gcgttcatac ttggatgagc tgtacggcac 1672621 gtcagtatcg gctgatctta cgaaaaaagg agagcggcat gtcattacgt tcaggcttga 1672681 aatcccgaat gaaaaatatt taaaagacca aacgccgctt ctcgagaaag ggctccagct 1672741 tctcgcagaa ctcgtctttt cacctgcttt ggagggagac gcttttcagt cacaatatgt 1672801 ggctcaagaa aaacggacgc ttaagcaaag aatccaagcc gtctatgatg ataaaatgcg 1672861 ttattcgaat ttaaggctga tacaggaaat gtgcaaaaat gatccttacg cgcttcatgt 1672921 caatggtgaa atcgacgatg tcgatgacat tacggcagag caattatacg aaacatacca 1672981 aagcgctatc caaaaagacc agcttgatct atatgttgtt ggcgacgtgg acagtaacca 1673041 ggtacaatcg gcaattgata agtatttcaa aacagaagag cgcactcttg gcatgattga 1673101 aaacaatcac gctgatgaaa aagttcagcc aaaagaagta attgatgaag aggatgtcaa 1673161 gcaaggaaaa ctgaatatcg gctaccgcac cagcatcact tatacagatc aggattatcc 1673221 tgctttacaa gtgtttaacg gattgttcgg cggattctct cattctaaac ttttcattaa 1673281 tgttcgggaa aaagccagtc ttgcttacta cgcggcttcg cgtatagaaa gttttaaagg 1673341 cttgttaatg gtgatgtcag gcattgaagt gaaaaatttt gaacaggcgg tttcgattat 1673401 tgctgagcaa ttccaggcaa tgaaaaatgg cgatttcagt gagcaggata tagcacagac 1673461 aaaggccgtt attcgaaatc aagtgctgga aacgattgat acagcatacg gtttatctga 1673521 gtttttatat cagcaggccg ctgctcaagt cgagattcct atcgaagact ttcttgccaa 1673581 tattgagaat gtcacaaaag aggatatcat taaagccggc gaaaagattc agcttgatac 1673641 gacttatttc ttaaaaggga cggagggtgc atcttgatca aaccaatcga atatgaacag 1673701 cttcaggaga cgctgtatca tgaaaaaatg tccaacggcc ttgatgttta cgttttgccg 1673761 aaaaaaggct tcaacaagac atatgcggtc tttacaacaa agtacggctc gatagataac 1673821 cggtttgtcc ctttaggtaa aaacgagatg gttcacgtgc cggacgggat tgctcacttt 1673881 cttgagcaca agctgtttga gaaagcggac ggagacgttt ttcaagattt cagcaaacag 1673941 ggggcttctg ccaatgcgtt tacgtcattt acaagaacgg cttacctttt ctcaagcaca 1674001 tcaaatgttg aacgcaattt agagacgctt atcgatttcg tacaggaccc atattttact 1674061 gaaaaaacgg ttgaaaagga aaaagggatt atcgggcagg agattaatat gtacgacgat 1674121 aaccctgatt ggaggcttta cttcggggtc attgaaaaca tgtacaaaga gcatcctgtc 1674181 agaattgaca tagcgggaac agtggaaagc atttcacata ttacaaaaga ccttctttat 1674241 gaatgctatg aaacgtttta tcacccgagt aacatgctcc ttttcattgt cggccctgta 1674301 gatcctgaag cgattatttc tcaggtaaga gaaaaccagg ggaaaaagcc gtatactgat 1674361 cagccggaga tcaaacgaga agaagtgaaa gagcaagaag cggttttccg aaaagaaaaa 1674421 gagatcaaaa tgaacgtgca gggaccgaaa tgccttgttg ggctgaaatc caaaaatccg 1674481 tttaaattag gcaaagagct cttaaagcat gaactttcaa tgaacttatt gcttgaagct 1674541 ctttttggca aaagctctgc ccagtatgaa tcactttatg aaaaaggata tattgacgaa 1674601 acgttcagct ttgattttac tgctgaatat gggttcggtt ttgcggcgat cggcggagat 1674661 acgcctgagc ctgatcaatt ggctgaagac atttcaagca tgcttttgcg cgccggtgaa 1674721 ctgattactg ctgaaaagat tgaacttgcc agaaagaaaa agatcggcac attcttaaaa 1674781 gcgctgaatt cccctgaata catcgccaat caatttaccc gttatgcgtt cttggatatg 1674841 agcctgtttg atgttgtaac ggtactcgag cagattaccc tcgaggatgt ccagaacgta 1674901 atacaagagg aaatcgctgc agacagactg actgtctgca aggttgttcc taaatcataa 1674961 acaaaacatc cctccagtgt gaggggtgtt tttctgcgga aagaaggaaa gaggatgaac 1675021 aaaacagcac taatcaccgg agcaagcggc ggcattggca aaagcatcag cgaaaccctt 1675081 gcagctagag gatacaatct gctgctgcat tacaatacaa atcaaaacgc ggcagcggag 1675141 cttgctgaaa aactaagtca gatgtttggc gtaaatgcgg agatattaca agctgacctg 1675201 tccgcgcaag atggagcaga taagctgaca agttcaattg ttcagccgat tgatgcgatt 1675261 gttttaaaca gcggacgaag ccattttggg ctgattacgg atgtagataa cgcaacggtc 1675321 caggaaatgg ttcagcttca tgtggcgagt ccgtatatgc tgacgagaaa ccttctgcca 1675381 ggcatgattc ggaataaatc gggagcgatt gtggctgtca gctcgatttg gggagagact 1675441 ggagcatcct gtgaagtgtt gtacagcatg gcaaaaggag ctcagcattc atttgtaaaa 1675501 ggattggcta aggagctggc gccaagcgga atcagagtaa acgccgtagc gccgggtgca 1675561 gttgatacaa atatgatgaa tcaatttacc ccggctgaaa aagaagagat cgctgatgag 1675621 attccgatcg gccggctggc ccggccgcaa gaaattgcgg atgcaacagc ttttctcctg 1675681 tctgaaaaag cgtcatatat caccggccaa attctgtcgg tgaatggcgg ctggcactgc 1675741 tgatccgaaa atattcggtg tatagtttct tttgcgaagg acacaataat cttgtaactt 1675801 cacatgaaat ggaggaaaca agcatgtcag tattagaaaa ctgggatagc tggaaaaact 1675861 tccttggcga ccgtctgaac tatgcgcaag ataaaggtat gagccaggat acgattacag 1675921 atcttgcgac agaaatcggc agctacttgg ctaatgaagt ggaatctaag aacgagcagg 1675981 aaaaagtgct ggcagatctt tggagtgtag catcaaaaga tgaacagcac gccattgcca 1676041 atatgatggt taagcttgtt gaaaataaca gcactcacta ggaagagagg ggatttttcc 1676101 tctctttttt atgttttcct catcacagca acattcttct ttctaattag agaaaaatgc 1676161 tttatgataa aggaaggtaa aattttgcca caatgaaggg ggtatatcat ttggcaaagc 1676221 tcgaatggta ttttgaatat gaaattcaag tgaaccgccc cggactgctc ggggatattt 1676281 catctcttct tgggatgctt tctatcaaca tcgtaacgat aaacggcgtc gatctttcca 1676341 gaaggggaat gctcctcagg tgccgccata tagatcaaat taaacgatta gaatcaatct 1676401 taaaaacgat ggaaacaatt aaagtaacga agcttagaga accgaggctt cgcgaccgtc 1676461 ttgccgtacg ccacggccgt tatattcaac gggatgccga tgacaagaaa acgttccgct 1676521 ttgaacggga cgagcttggc ttattagtcg attttatggc cgaattgttc aaaaaagaag 1676581 gccataaatt aatcggaatc agaggtatgc cgcgtgtcgg gaaaacggaa tcgattgtag 1676641 cctctagtgt gtgcgagcaa aaggtggctg tttgtgtcat caaccttgct gaagcagacg 1676701 ataagaagcc agctgattgc cgatgaatac agcactgaaa atgtctttat cgttgacgga 1676761 attgtgtcaa cacgaagagg gtcagaacgc catctccagc tggtccgaga aatcatgcgg 1676821 ctgcctgcaa caaaagtggt ggagcatccg gacatattcg ttcaaaatac agagtataca 1676881 ctagatgact ttgattatat tattgaactg agaaatgacc ctgatgaggt tattacatat 1676941 gaacatgccg aggaacccca aatgtttgat caatccgggt tttcaagctt tgatttttaa 1677001 aattggaagg tgtttgttgt gactgaacta ggaatccggc tcaaagaagc cagagaggaa 1677061 aaagcaatgt cattggatga tctccaagcg gcaacaaaga ttcaaaaaag gtatttaacc 1677121 gccttggagg aaggaaacta tgacattatt ccggggaagt tttatgttcg ggcattcatc 1677181 aagcaatatg cagaagccgt tgggcttgat gcggatcagc tgtttgagga gcataaaaaa 1677241 gatatcccta atacgtatca tgatgatgtg tctgaaaaga tctccggcat gaatcttcaa 1677301 aaggaaatgc caaagccagc atctaaggcg ctggagctgc tgccaacaat acttgttatt 1677361 ctcggcgtga ttgtcgtgat tgccattgtg tacgcgatca ttcaatttgc caatcacaaa 1677421 aacagtgatg atcacaatgc ggcatcagaa aaagcaatta cgcaaagtga gagcaagtac 1677481 gaaatcccta aagattcaac gctgaaagag aatcaaaata acagctctga aaaagagaca 1677541 gacactaaaa aagaaacgaa agaaaacgaa gataagaaaa aagaaaatga cagtgagaag 1677601 ctggagatta aagctgctgg cactgaagga tcgttaacga cttatgaagt gtccggcgct 1677661 gataaaatcg agctggaact gaaggcatca gacagctcct ggattagagt gcgcgatgaa 1677721 aacagcagct ctttaaaaga aggaacgctg aaaaaagacg aaacctataa aaaagacata 1677781 actgatcaga aacaagttga tatccgcacc ggatatgcac ctaatctgaa aataaaaatc 1677841 aacggtaagg ttctttcata tgaacttgat ccgaaaaaag tgatggcaca aaccataaag 1677901 attgtaaata aaaaggaaga aaagtcatct taattaccag atgacttttc ttcacgtccg 1677961 agtatgaaat tggaggggct ttatgtttaa cttaccaaat aaaatcacac tagctagaat 1678021 cgcattaatc ccaatcttca tgattatcat gctggcgccg tttgactggg gcaggctcga 1678081 agttggagac gaatccatcc cggtcgcaca tttggcgggg gccattctat ttattattgc 1678141 atctacaaca gactgggtgg acgggtatta tgcccgaaaa ttaaatctcg taacaaactt 1678201 cgggaaattt cttgatccgc ttgcggacaa actgctcgta tccgcagcgt taattatcct 1678261 tgttcaattt gatctcgctc cagcttggat ggtcattgtg attatcagca gggagtttgc 1678321 cgtgacaggt ttaaggcttg tcttagccgg aacaggagaa gtcgtagctg ctaacatgct 1678381 tggtaaaatc aaaacctggg cacagattat tgcggtatct gcattgcttc ttcataatct 1678441 tccatttgaa cttgtgtcat tcccgtttgc agacttggcg ctgtgggtag ccgtcttctt 1678501 tactgtcgtc tcaggctggg aatatttctc taaaaattgg gaagcgttaa aaacatctaa 1678561 ctaagaaaga aggacttcgt catggaattt ccaaaaaaag cagaaataat tgcagtcggt 1678621 tcagagttgc tgcttggtca aatcgccaat acaaatgctc aatttatcag caaacagctc 1678681 gctgaaatcg gggtcaacgt attttatcat acagcggtcg gagataaccc ggagcggctg 1678741 aagcaggtca tccgcattgc tgaagaacgc tctgacttca ttattttttc aggagggctt 1678801 ggacccacaa aagatgatct gacgaaagaa acgattgcaa atacgctggg acgtccgctt 1678861 gtgttaaatg atgaggcatt ccaatccatt gaggactatt tcaaacgaac aaaacgcacg 1678921 atgtcaccta ataaccgaaa acaggcgctt gtgatcgaag gctctgacgt gctggcgaat 1678981 cactttggaa tggccccggg aatgctcaca gagcatgaat cgcgctatta tatgcttctt 1679041 cctggaccgc cgagcgaatt gcgtccaatg tttgaaaacg aggcaaagcc tcttctgctg 1679101 aaaaagatgg gttcaaatga aaaaattgtg tcaactgttc ttcgcttttt cggtatcggt 1679161 gaatctcagc ttgaagccga tttggaagat attattgatg cacaaaccaa tccgacaatt 1679221 gcgcctttgg cggctgatgg agaggtgacg ctgcgtctga cagccaaaca cgccgatgaa 1679281 aaggaaacag agcgtctgtt aaaagaaaca gaggccgtta tcttagagcg tgtcggtgaa 1679341 tttttctatg gttacgatga tacttctctt gtaaaagagc tatctatagc atgtaaggaa 1679401 aaaggcataa caatttctgc ggcagaaagc tttaccggag ggctgttttc tgaatggctg 1679461 acggatcata gcggtgcctc aaaattattt gccgggggcg ttgtttgcta tacaaacgac 1679521 gtgaagcaga atgtgcttgg tgtcaagaag gaaacattag atcgttttgg ggcggtcagc 1679581 aaggagtgcg catccgaact ggctaagggt gttcaaaaac tcactggcag cgatatcggc 1679641 attagcttta ctggtgtagc aggacctgat gctcaagaag ggcatgagcc tgggcatgtg 1679701 tttatcggca tttccgcaaa tggtaaagaa gaggttcacg agtttcactt tgcgggctcc 1679761 agaacgggga tcagaaaacg cggcgctaaa tacggctgcc atttaatctt aaagctttta 1679821 gagcaaaaat aatattttca gcacattatc ctcctaagaa aacatgattt ctctgataca 1679881 ttatgatatt ttgataggaa tcacgccaag aaaaaatccg aatatgcgtt cgcttttttc 1679941 ttggcaaatc ccttcaaaca gggtatagta tatgtagtgg taacataaag gaggaaaaaa 1680001 tagaatgagt gatcgtcagg cagccttaga tatggctctt aaacaaatag aaaaacagtt 1680061 cggcaaaggt tccattatga aactgggaga aaagacagat acaagaattt ctactgtacc 1680121 aagcggctcc ctcgctcttg atacagcact gggaattggc ggatatcctc gcggacggat 1680181 tattgaagta tacggtcctg aaagctcagg taaaacaact gtggcgcttc atgcgattgc 1680241 tgaagttcag cagcagggcg gacaagccgc gtttatcgat gcggagcatg cgttagatcc 1680301 ggtatacgcg caaaagctcg gtgttaacat cgaagagctt ttactgtctc agcctgacac 1680361 aggcgagcag gcgcttgaaa ttgcggaagc attggttcga agcggggcag ttgacattgt 1680421 cgttgtcgac tctgtagccg ctctcgttcc gaaagcggaa attgaaggcg acatgggaga 1680481 ttcgcatgtc ggtttacaag cacgcttaat gtctcaagcg cttcgtaagc tttcaggggc 1680541 cattaacaaa tcgaagacaa tcgcgatttt cattaaccaa attcgtgaaa aagtcggtgt 1680601 tatgttcggg aacccggaaa caacacctgg cggccgtgcg ttgaaattct attcttccgt 1680661 gcgtcttgaa gtgcgccgtg ctgaacagct gaaacaaggc aacgacgtaa tggggaacaa 1680721 aacgaaaatc aaagtcgtga aaaacaaggt ggctccgccg ttccgtacag ccgaggttga 1680781 cattatgtac ggagaaggca tttcaaaaga aggcgaaatc attgatctag gaactgaact 1680841 tgatatcgtg caaaaaagcg gttcatggta ctcttatgaa gaagagcgtc ttggccaagg 1680901 ccgtgaaaat gcaaaacaat tcctgaaaga aaataaagat atcatgctga tgatccagga 1680961 gcaaattcgc gaacattacg gcttggataa taacggagta gtgcagcagc aagctgaaga 1681021 gacacaagaa gaactcgaat ttgaagaata aaaataaaat aagtttcaaa tgatacaaaa 1681081 ggctgagtga aaaactcagc ttttttgtat tttgcaaaaa aatgataaaa atattgcttt 1681141 ttttgacaac ttttttaggg ctttattcgt ctaacaaaac gtgtgcaaaa tggaatttat 1681201 tttgggagga aaaaatgaat gacaagccca acccgcagaa gaactgcgaa acgcagacgg 1681261 agaaaactaa ataaaagagg aaaactgttg tttggtcttt tagcagtgat ggtttgcatt 1681321 acgatttgga atgctcttca tcgaaatagt gaagaaaacg aaccatctca agaaactgca 1681381 gcggtttcaa ataccgatca gaaaaaagag gtcaaaaaga aaactgccaa aaaatcagag 1681441 gaacaaatca aaacagtgga tcgaaaccaa aaaatcagca attatttaaa agagatcggt 1681501 ttcagcggaa cagccatgat tgtcagaaat ggagaaatcg taacaaataa aggttttggc 1681561 tatgctgacc gtaaacacta cattcaaaat aatccattga catcttttta tgtcggttca 1681621 tcacaaaaag cgctgattgc aactgctatt ttgcagcttg aggaaaaggg gaaacttcag 1681681 acaagtgatc cggtaagcac gtatttacct cattttccca acggacaaac gattactttg 1681741 aagaatctgc ttacacatac atcggggata aacggacata ttgaaggaaa cggcgccatt 1681801 actccggacg atttaataaa agatatagaa cttcagggaa tcaaacgtca gccgggcgta 1681861 tgggactaca aggattccaa ctattctgtt cttgcttata ttattgctga agtaagcggt 1681921 gagccctatg aacagtacat aaagaatcat atttttaaac ctgcgggaat gacgcatgca 1681981 ggcttttaca aaacatatga aaaagaacct tatcctgccg tcgggtataa gatggagggc 1682041 agcaaaacag ttacaccgta tatacctgat ttatcccagc tgtatggagc gggtgatatt 1682101 tatatgagcg ctatagatat gtacaaattt gaccaagcgc tgatagacgg aaaactgtat 1682161 tcgcaaaaaa gctatgaaaa gatgtttacg ccagggagca gctccacata cggcatggga 1682221 ttttatgttg ctcccggaag ctattcaaac catggtgtta tgccgggctt caatatcttg 1682281 aacagcttta gcaaatctgg gcaaaccatt gttattttgt tctcaaacat tcaaaataat 1682341 gctaaattgg gccaagtgaa caataaaata taccagcttc taaatcaaga atgattggcg 1682401 atcttctttt ggatgaattg cattcggcac gtgaaaagaa gactggcctg caaacgttaa 1682461 gatggcaagc ttgacaagta tttccgacac atttacaatg aagttgtaac atttgttttt 1682521 ttaacatgat tgttaaacca tttaaacttg acaagggcga tgaacacact cattccctgt 1682581 gaaggttctg tatgttgaga aaactagaca atgtacatgc cgacactttt taagcaacaa 1682641 ccaagttcat agcaagagga ggtgaaagta tgaccccaat tatgatggtt ctcatctcca 1682701 ttttgctgat tctactcggt ttagttgttg gctactttgt tcgtaaaacc attgccgaag 1682761 cgaaaattgc gggcgcacgc ggtgcagccg agcaaattct tgaagatgcg aagcgtgatg 1682821 ctgaagcact gaaaaaagaa gctctgcttg aagcaaagga tgaaatccac aaacttcgaa 1682881 tagatgctga acaggaagtt cgtgaaagac gaaatgagct tcaaaaacaa gaaaaccgtt 1682941 tactccaaaa ggaggaaaac cttgatcgca aacatgaggg aattgataaa cgggaagcga 1683001 tgttggagaa gaaagatcat tctctgaatg aacgacaaca acatattgaa gagatggaaa 1683061 gcaaagtgga tgagatgatt cgtatgcagc agtctgagtt ggaacgaatt tcgagtctga 1683121 ctcgtgacga agcgaaacaa atcattcttg agcgggttga aaacgagctt tcacatgaca 1683181 tcgccatcat gacaaaagaa actgaaaacc gtgcgaaaga agaggcggat aagaaagcga 1683241 aaaacattct ttcactcgcc ttacagcgct gcgcagcgga ccacgttgcc gaaacaacgg 1683301 tatcagttgt caatcttcca aatgatgaga tgaaaggacg tatcatcgga cgggaagggc 1683361 gtaacattcg tacgcttgaa acgctgacag gaattgacct gattattgat gatacgcctg 1683421 aagctgtcat tctttccgga tttgatccga tcagacgtga gacagccaga attgctcttg 1683481 ataaactcgt tcaggatggc cgtattcatc cggcacggat tgaagaaatg gttgaaaaat 1683541 ctcgccgcga ggtcgatgac tatattcgtg agatgggtga gcaaacgaca tttgaggttg 1683601 gcgttcatgg cctccaccca gatctcatca agatcctcgg ccgcttaaag ttccgtacaa 1683661 gctacggtca aaatgtgctt aagcattcca tggaagtcgc attcttggcc ggtctaatgg 1683721 catcggagct tggtgaagac gcaaagcttg ctaaacgtgc gggtcttctt cacgacatcg 1683781 ggaaagcaat tgaccatgaa gtagaaggaa gccacgttga gatcggggta gagcttgcga 1683841 ccaaatataa agagcaccca gtcgtgatta acagtattgc atcacaccac ggggacgagg 1683901 agccgacttc cattattgct gtactggtag ctgcagcaga tgcgctttcc gctgcaagac 1683961 ctggcgcaag aagtgagacg ctcgagaatt atattcgaag acttgaaaaa cttgaagaaa 1684021 tttctgagtc ctacgaaggt gttgaaaaat catttgccat tcaggctgga cgcgaagtgc 1684081 gaattatggt gaagccggat tcaattaatg atcttgaggc tcatcgactg gcgcgagata 1684141 tccgcaagcg aattgaggac gagctcgatt atccaggtca tattaaggtg acagtaatca 1684201 gagagactcg agccgtagag tatgcaaaat aaagtgatgc gctaagcatc actttatttt 1684261 tttgacggca aggaattttc aagaagaaag gatttacaaa atgagaattt tatttatcgg 1684321 agatgttgtc ggttcaccgg gccgtgacat ggtcaaagaa tatgtaccaa agctaaaaac 1684381 aaaatataag cctcacttta ccattattaa tggtgaaaac gccgcacatg gaaaaggcct 1684441 gacggaaaaa atttatcaca gcttaatcca gtccggcgca gatgcaatca caatggggaa 1684501 ccacacatgg gacaaaaaag aaatatttga ttttatagat gacgttccga acttggttcg 1684561 cccggcaaac tttcctgaag gaacaccggg gaaagggatc acatatgtga aagcaaacgg 1684621 caaagaacta gcagtcatta atttgcaggg acgtacgttt ttgccgccgc ttgatgaccc 1684681 gtttttaaaa gcggatgaat tgatcgcaga agctgcgaaa agaacaccgt acatttttat 1684741 tgactttcat gccgaagcga caagtgaaaa gctcgcactt ggctggtaca cggatggacg 1684801 ggcatcggct gtagtaggaa ctcatacaca cgtgcaaaca gcggataacc gcattttgcc 1684861 gaagggaacg gcatatatta ctgatgtggg aatgactggc ccgtatgacg gtatactggg 1684921 gatggacaga gagacgatta ttaagcgatt caaaacgaac cttccagtcc ggtttactgt 1684981 cgctgaagga aaaacaacgc tcagcggagt tgtcattgac attgacgatc aaacgaaaaa 1685041 agccgtgaaa attgagcgta ttttaatcaa cgatgatcac atgttctttg aatagttgaa 1685101 catatggtta ttttataaaa atattaaaaa gaaaagcagg aatatagcaa ctccttagtg 1685161 aatatagtaa aaatggaagg tagcccgcta tttttgaaaa gcattgtggg gatggctttt 1685221 tggatagcaa catctaataa tgattgttct aatgaacact cacttatcca ttgtaaaact 1685281 aagggggagc agaaatggaa atcttaaaag tttcagcaaa atcgagtcca aattcagtgg 1685341 caggtgcgct tgcaggcgtg ttgagagagc gaggagccgc cgagattcaa gcgatcggag 1685401 cgggtgcatt aaaccaggct gtaaaagctg tggcgattgc caggggattt gtggcgccaa 1685461 gcggcgttga tttgatttgt attccggctt ttacagatat tcaaatcgat ggggaagaaa 1685521 gaacagcgat taaattaatc gtggagcctc gctaaaaaca aataaagcat tctcaacctg 1685581 tttgcgtaat gcaaacaggt tgtttttcat ttattgtgat attttctccc gatagtattt 1685641 ttagcacata aatgagcgaa tatacaaaat cagaaatgag ctaaaacgtt tcaaaaaaaa 1685701 tttccgccca tttttcaaga cagatacttt tgtccttctg gaaaagacag ttctgtttac 1685761 gcttattcca tatcatggta caatccgaat ataacaagaa tttttcaagg aggattgtac 1685821 atgcagagtg gaaagatgaa agctctaatg aaaaaggacg gggcgttcgg tgctgtgctg 1685881 actgaagttc ccattcctga gattgataaa catgaagtcc tcataaaagt gaaagccgct 1685941 tccatatgcg gcacggatgt ccacatttat aattgggatc aatgggcacg tcagagaatc 1686001 aaaacaccct atgttttcgg ccatgagttc agcggcatcg tagagggcgt gggagagaat 1686061 gtcagcagtg taaaagtggg agagtatgtg tctgcggaaa cacacattgt ctgtggtgaa 1686121 tgtgtccctt gcctaacagg aaaatctcat gtgtgtacca atactgctat aatcggagtg 1686181 gacacggcag gctgttttgc ggagtatgta aaagttccag ctgataacat ttggagaaat 1686241 cccgctgata tggacccgtc gattgcttcc attcaagagc ctttaggaaa tgcagttcat 1686301 accgtactcg agagccagcc tgcaggagga acgactgcag tcattggatg cggaccgatt 1686361 ggtcttatgg ctgttgcggt tgcaaaagca gcaggagctt ctcaggtgat agcgattgat 1686421 aagaatgaat acaggctgag gcttgcaaaa caaatgggag cgacttgtac tgtttctatt 1686481 gaaaaagaag acccgctcaa aattgtaagc gctttaacga gtggagaagg agcagatctt 1686541 gtttgtgaga tgtcgggcca tccctcagcg attgcccaag gtcttgcgat ggctgcgaat 1686601 ggcggaagat ttcatattct cagcttgccg gaacatccgg tgacaattga tttgacgaat 1686661 aaagtggtat ttaaagggct taccatccaa ggaatcacag gaagaaaaat gttttcaaca 1686721 tggcgccagg tgtctcagtt gatcagttca aacatgatcg atcttgcacc tgttattacc 1686781 catcagtttc cattagagga gtttgaaaaa ggtttcgaac tgatgagaag cgggcagtgc 1686841 ggaaaagtaa ttttaattcc ataaaggggg ataaacatga cgaaggaatt tgagttttta 1686901 aaagcagagc ttaatagtat gaaagaaaac catacatggc aagacataaa acagcttgaa 1686961 tctatgcagg gcccatctgt cacagtgaat caccaaaaag tcattcagct atcttctaat 1687021 aattacctcg gattcacttc acatcctaga ctcatcaacg ccgcacagga ggccgttcag 1687081 cagtatggag ccggcaccgg atcagtgaga acgattgcgg gtacatttac aatgcatcaa 1687141 gagcttgaga aaaagctggc agcctttaaa aaaacggagg cggcacttgt attccaatca 1687201 ggcttcacaa caaaccaagg cgtactttca agtattctat caaaagagga cattgtcatc 1687261 tcagatgaat tgaaccatgc ctctattatt gacggaattc gactgacaaa ggcggataaa 1687321 aaggtgtatc agcacgtcaa tatgagtgat ttagagcggg tgctgagaaa gtcaatgaat 1687381 tatcggatgc gtctgattgt gacagacggc gtattttcca tggatggcaa catagctcct 1687441 ctgcctgata ttgtagagct cgctgagaaa tatgacgcat ttgtgatggt ggatgacgcc 1687501 catgcatccg gagtacttgg cgaaaacggc aggggaacgg tgaatcactt cggtcttgac 1687561 ggcagagtgc atattcaggt cggaacatta agcaaggcaa tcggagtgct cggcggctac 1687621 gctgcaggtt caaaggtgct gatcgattat ttgcgccata aaggccgtcc atttttattc 1687681 agcacatctc atccgccggc agtcactgca gcttgtatgg aagcgattga tgtcttgctt 1687741 gaagagccgg agcatatgga gcgcttgtgg gagaatactg cctattttaa agcaatgctt 1687801 gtgaaaatgg gtctgactct cacgaagagt gaaacgccga ttcttcctat tttaataggt 1687861 gatgaaggtg tggcaaagca attttcagat cagctccttt ctcgcggtgt ttttgcccaa 1687921 agtatcgttt tcccgactgt agcaaaggga aaagccagaa ttcgcacgat tataacagca 1687981 gagcacacca aagatgaact ggatcaggcg cttgatgtca tcgaaaagac ggcaaaggag 1688041 ctccagctat tgtaacaaga ggaagagttt actcttcctc ttttgattcc ttattgatta 1688101 ttattctcaa tgagtgtaca atgataggtt gccagttgtg cagagcttca ataaccttta 1688161 tactgaaggg tggaagtttg gtttgaaagg agaaaatatg acatgaatga aaaacaaaaa 1688221 ttagagagcg gacaagttca tccatcggac aaaaaatccg agaaggatta cagcaagtac 1688281 tttgaagctg tttacattcc gccttcttta aaagacgcga aaaaacgagg caaggaagcc 1688341 gttacttatc ataatgactt taaaatttct gaacaattta aaggattggg agacggaaga 1688401 aagttctata tccgtacgta cggctgccaa atgaatgaac acgatacaga ggttatggca 1688461 gggatcttta tggcgctcgg ttacgaagcg acaaactctg ttgacgatgc caatgtcatt 1688521 ttgttaaata catgtgcaat ccgtgaaaat gctgaaaaca aggtgtttgg tgagctcggg 1688581 cacttaaaag cactgaaaaa aaacaatccc gatctgattt taggcgtgtg cggctgtatg 1688641 tcccaagagg aatcagtcgt gaaccgtatt ttgaaaaaac atccgtttgt cgatatgatt 1688701 ttcggaacgc ataacattca tcgcctgccg gagcttttgt cagaagcata cctttcaaaa 1688761 gaaatggttg tagaagtttg gtctaaggaa ggggacgtta ttgaaaacct tccaaaagtc 1688821 cgaaatggaa aaattaaggg ctgggtcaat atcatgtacg gctgtgacaa attctgtacg 1688881 tattgcattg tgccttacac acgcggaaaa gaaagaagcc gccgccctga ggatatcatt 1688941 caggaagtga gaaggctcgc aagtgaaggc tataaggaaa ttactctgtt aggccaaaac 1689001 gtaaacgcgt atggaaaaga ctttgaagat atgacgtacg gacttggtga tttgatggat 1689061 gaactgagaa aaatcgatat cccgagaatc cgttttacaa cgagtcatcc gcgcgacttt 1689121 gacgaccgcc tcattgaagt gctggcaaaa ggcggaaatc tgcttgatca cattcatctt 1689181 ccggttcaat caggaagctc agaagttctc aagctgatgg cccgcaaata tgacagagag 1689241 cgttacatgg agctggtgcg aaaaattaaa gaagcaatgc caaacgcttc tttgacaacg 1689301 gacattatcg tcggatttcc aaatgaaacg gacgaacagt ttgaagaaac gctttctcta 1689361 taccgtgaag tggagtttga cagcgcctat acgttcattt actctccgcg tgaaggcact 1689421 ccggctgcta agatgaaaga taatgtaccg atgcgtgtga aaaaagaacg cctgcagcgt 1689481 ctaaacgcac tggtgaatga aatttctgct aaaaaaatga aggaatacga aggcaaggtt 1689541 gtcgaagtat tagttgaggg tgaaagcaaa aataaccctg atattcttgc tggctatact 1689601 gaaaaaagca agcttgtcaa tttcaaaggg ccgaaggaag ccatcggcaa aatcgtccgc 1689661 gtgaaaatcc agcaagcgaa aacatggtcg cttgacggag aaatggtagg agaagcaatc 1689721 gaggtgaaat gagatgacgc tctactcaaa aaaagacatt gtgcagcagg ctcgaaacct 1689781 tgcaaaaatg atttctgaaa cagaagaggt tgattttttc aaacgggctg aagcgcaaat 1689841 caatgagaat gacaaagtgt ccacaatcgt taatcagatt aaagccctgc aaaagcaggc 1689901 tgtcaatctg aagcattatg aaaagcatga agcgctcaaa caagtagaag caaaaattga 1689961 cgcgctgcaa gaagagcttg aagagattcc tgttatccag gaattcagag actcgcaaat 1690021 ggaagtaaat gacctactgc agctcgttgc acacaccatt tccaaccaag tcacaaatga 1690081 aatcatcaca tcaaccggag gcgacctgct gaaaggggaa accggttcaa aggtgaagca 1690141 ttcaaataac agctgttctc tctaaacacg gtgcctttac aggcccgtgt ttttttatca 1690201 tttgtgcggt taaaaatgaa ctaaataatc tatgtaccaa atgttcaatt ggtttttctg 1690261 tgctcagccg cgtataaact ttatcgcact tataagtaaa gtttctaggc acccctgcat 1690321 acaatggaac agaaactttg tatttttata ttttatttat aaaaatgcac actagacaaa 1690381 tgcccagcat aagataacac gaagaagaac aaggaggcat gccggaatgt ctgaatacag 1690441 ggaaattatt acgaaggcag tagtagcgaa aggccgaaaa ttcacccaat gcaccaacac 1690501 catctcgcct gagaaaaaac cgagcagcat tttgggtggt tggattatta accacaagta 1690561 tgacgctgaa aaaattggaa aaacggtaga aattgaaggg tattatgata taaacgtatg 1690621 gtactcttac gcggacaaca caaagacaga ggttgtcaca gaacgggtaa aatatgtaga 1690681 tgtcattaaa ctcagataca gagacaataa ttacttagat gatgagcatg aagtgattgc 1690741 caaagtgctt cagcagccaa actgccttga agtgaccatt tcgccgaatg gaaataaaat 1690801 cgttgtgcag gcagaaagag aatttttggc ggaagtggta ggggaaacaa aggtagttgt 1690861 tgaggtcaat cctgactggg aagaggatga cgaggaagat tgggaagatg agcttgatga 1690921 agagcttgaa gacatcaacc cggagttttt agtgggagat cctgaagaat aaaaaaggga 1690981 ctaggggaga cagtaccccc aagtctcttt tttatattga tatatcattc ttttatcact 1691041 ttttgtttat gttataatga aggttggaaa atagaaacgt tgatacatag tgagggatta 1691101 aacaatggcc ggttatacgc ctatgataca gcaatattta aaaataaagg cagagcacca 1691161 ggatgccttt ttattttttc gcctgggtga tttttatgaa atgttttttg aggacgccaa 1691221 aaaagcgtca caagagctgg aaattacgtt aacgagcaga gacggcggtg cggctgaaaa 1691281 aataccgatg tgcggtgtgc cgtatcattc tgcttccgcg tatatcgaac agcttattaa 1691341 aaaaggatac aaagtggcga tctgtgaaca gacggaagat ccgaaagccg caaagggcgt 1691401 tgtgaaaaga gaagtagttc agctgattac gcccggaact gtaatggacg gcaaaggcat 1691461 ccatgagtcg gaaaataatt ttatcgcatc tgtttcagcc tgctcgaacg gatacggact 1691521 tgctctgtct gatttaacaa cgggagaaaa tttggctgtt ttgattgaac ggcttgaaga 1691581 cgtcatatca gaaatttatt cagtcggcgc acgggaaatc gtggtttcag gaagcttgga 1691641 tgccgataca gtggcacagc tgagagagcg gtgcggtgca acgatttcaa ttgaagacgg 1691701 agaaacagac gaacacgtaa cgatcattga gcacttaaat aatgaagata taacaaaaac 1691761 atttctgcgc ttatatacgt atttgaaaag aacccaaaag cgcagccttg atcatcttca 1691821 gcccgtgcag gtgtatgagc ttgaggaagc gatgaaaatt gacttgtact caaagcgtaa 1691881 tctggagctg accgaaacga ttcgttcgaa aaataaaaaa ggctcccttt tgtggctgct 1691941 ggatgaaaca aaaacggcaa tgggaggccg gctacttaaa cagtggattg accggccgct 1692001 tatcagagtc aatcaaatcg aagagcgcca agaaatggtg gaaacattaa tgtcccattt 1692061 ctttgaacgg gaagatctgc gtgaacgttt aaaagaagta tatgacttag aacgccttgc 1692121 cggccgcgtt gcattcggaa atgtcaatgc ccgggatttg attcagctga aggaatcgtt 1692181 aaagcaagtg cctggcatca aacagctggt tgcttcactg gctcatgaca aggccaagga 1692241 acgtgcaaag cgcattgacc cttgcgggga tgtacttgaa ctgctggaag aagcgctgta 1692301 cgaaaaccct cctttatcgg taaaagaagg gaacctgatt aaagatggtt ataatcaaaa 1692361 gcttgatgaa tatcgtgatg caagcagaaa cggaaaagac tggattgccc gcctggaaca 1692421 gcaggagcgg gaatacacag gcattcgctc tttaaaggtc ggctttaata aagttttcgg 1692481 ttattacatt gaagtgacaa aagcaaactt gcatttgctt gaggaagggc gttatgagcg 1692541 gaagcagacg ttaaccaatg cagagcgcta cattacacct gaattaaaag aaaaagaagc 1692601 gctcatttta gaggcggaaa ataacatctg tgagctggag tacgagctgt ttaccgagct 1692661 gcgcgagaaa gtgaagcagt atattccgcg gctgcagcag cttgcaaaac agatgagcga 1692721 gctggacgca ctgcaatgct ttgcgacaat cagtgaaaat cgccactaca cgaaaccaga 1692781 gttctctaaa gatgaagtcg aagtgattga aggcagacac ccggttgttg aaaaagtcat 1692841 ggacagccag gaatatgtcc cgaacaactg tatgatgggc gataacagac aaatgcttct 1692901 cattacaggt ccaaacatgt cagggaaaag cacgtatatg agacaaatcg cgctcatttc 1692961 cattatggcg caaatcggct gctttgtacc cgcgaaaaaa gcggtgctcc cgattttcga 1693021 tcaaattttt acgcgaatcg gcgctgcaga tgatttgatt tccggacaaa gtacatttat 1693081 ggtagaaatg cttgaagcga aaaatgcgat tgtcaatgcg acgaaaaaca gcctcattct 1693141 gtttgatgaa atcgggcggg gaacgtccac ttatgacggc atggcgctgg cacaggcgat 1693201 tattgaatat gttcacgatc atatcggcgc caagacgctg ttcagcacac actatcacga 1693261 gctgaccgtt cttgaggaca agctgcccca gctgaaaaac gttcatgttc gcgctgaaga 1693321 atataacgga acggttgtct ttcttcatca aattaaagaa ggtgcggctg ataaaagcta 1693381 tggtatccat gtagctcagc ttgccgaact gccgggagat ctgattgcgc gcgctcaaga 1693441 tattttaaaa gagcttgagc attcaggaaa caaaccggaa gtgccggtgc agaaacctca 1693501 ggtgaaagaa gagccggcac agctgtcctt ttttgacgaa gcggaaaagc cggctgaaac 1693561 accaaagctt tcaaaaaaag aaaagcaagt gatcgatgct ttcaaatcac ttaatatact 1693621 ggatatgaca ccgcttgaag cgatgaatga aatgtacaag ctgcaaaaga aattacatta 1693681 aaacggggtg atgaatgtgg caaaagtcat ccaactgtca gatgagcttt caaataaaat 1693741 agcggcgggc gaggttgtgg aacggcccgc ctcagtcgtc aaagaattgg tggaaaatgc 1693801 gatcgacgct gacagcacag tcattgaaat cgatattgag gaagcaggcc ttgcatccat 1693861 tcgggtcttg gataacggcg aaggaatgga gaatgaagat tgcaagcgag ctttccggcg 1693921 ccacgcaacg agtaaaataa aagatgaaaa tgatttattc agggtgagaa cgctcggttt 1693981 caggggagaa gccctgccga gtatcgcgtc agtctctcat ctggagatta caacaagcac 1694041 tggtgaagga gctgggacga agctcgtcct ccaaggagga aacatcattt ccgaatcgcg 1694101 ttcctcaagc aggaagggaa ctgaaattgt cgtttccaac ctgtttttta acacaccggc 1694161 ccgtttgaaa tatatgaaaa ccgttcatac agagcttgga aacattacag atgtggttaa 1694221 ccgtattgct ctggcgcatc cagaggtatc gatccgcctg cgccatcatg ggaaaaacct 1694281 gcttcaaacg aacggaaacg gagatgtgcg ccatgtactg gcagcgattt acggcacggc 1694341 tgtcgccaaa aaaatgcttc cgctgcatgt gagctccttg gattttgaag taaagggata 1694401 tatcgccctc ccagagatta cacgggcgtc gagaaactat atgtcgtctg tggtcaatgg 1694461 ccgttacatt aaaaatttcc cgctcgtcaa agcggttcat gaaggctatc atacgcttct 1694521 gccgatcgga cgccatccga ttacttttat agaaattacg atggacccga ttttagtcga 1694581 tgtcaacgtg catccatcga agcttgaggt ccggctcagc aaggaaacag agcttcatga 1694641 cttaatacgt gacggaatta aagatgtgtt taaacagcag cagctgattc ctagtgccca 1694701 ggtcccgaaa aaatcagcac ctgccatcaa aaatgagcag cagtttataa cctttgatga 1694761 aaagcctccg gaaaaaaaag ttccggaaaa atcgactgcg ccatcttatt caccgatgaa 1694821 gctcagctca gtcgtaaaag agccggttga tgcggaggaa aaattgcccc ctctccaatt 1694881 tgatgctcct cctatcgttg atcaggaaca aacccttgag gtgtccgatg tttcagcaga 1694941 acagcctgaa acatttgagc aggaatgcca tgaggaacag ccgcagccag cgtctgatcg 1695001 ggttccaatt atgtacccga ttggccagat gcacgggact tatatattgg cacaaaacga 1695061 aaacggccta tatattatcg accagcacgc cgcccaagaa cgtattaaat atgagtactt 1695121 ccgtgaaaag gtgggggagg ttgagcctga ggtgcaggag atgattgtac cgctgacgtt 1695181 ccactactcc acaaatgagg ctttgattat tgaacagcac aaacaagagc tcgaaagcgt 1695241 cggtgtcttt ttagagtcat tcggctctaa cagttacatc gtccgctgcc acccagcctg 1695301 gtttccaaag ggagaagaag cagagcttat agaagaaatc attcagcagg tgctcgactc 1695361 caaaaatata gatattaaaa aacttcgcga ggaagcggcg attatgatga gctgcaaagg 1695421 ctccatcaaa gcaaatcgcc acctcagaaa cgacgaaatc aaagcgcttc tggacgacct 1695481 ccgaagcaca tcagacccat ttacatgccc gcacggccgc ccgatcatca ttcaccactc 1695541 gacatatgag atggaaaaga tgttcaaacg cgtgatgtag cgggggtggt aggcattgat 1695601 ccattctctg aatggatcaa tgcttttttt gtactccttc gagtgtcaga ttataagaaa 1695661 cggttgtaaa cgtgtgagca gtgttaacgc attatacttc atggttcctc cgtataacaa 1695721 aatttccatt tacaggcaat tgggattaat gtatattttg ggtgaggggg tggaaacata 1695781 tggcatgtgg tccgaagatc attatctttt tggatgaact tgatgatcca aatgtgagaa 1695841 tcattttaga atgcagaatt taaattacaa cattgtgttt tgctccctgt tcgtgtgaac 1695901 agggagattt tttcgtttat ataactggtg atgtccaaat atagggtgtt atgaattttc 1695961 catatctgcc atcggcttta agctgcttct ctattaggct ggttatcaaa agcaagttca 1696021 atgatagcca tgaaagctga tatcacaaca agcaagacat ctggaatata aatagactgc 1696081 ataaagtaat ctgcaaaaca gatcgttata agattgctga taaaatacag tataaaagca 1696141 aaaagtgcag tctttttcaa tgaaagtgat tttgccaaaa tgatagagat aatctttgtg 1696201 agtgggtcta tgattaaacc tacagcaaag caggctaaaa taaataaagc taatgtttga 1696261 ttggaagcgt atgtgatgcc aagtatggag aataagcctt tcatcccgaa gaaaaagccg 1696321 ccgaagatga ctgcaagcgc gatggccgcg ataaaagtaa tagatacaat tccgattaat 1696381 tttgatctca ggttaaaatc tttagagtgc tcgttctgtt ctttttggtt catgtatgac 1696441 actcccttca cctgcttact catacaaaca gcacccttga atcagcccaa aatatctata 1696501 agtctgtttt ctgacgaaaa tagtatagca tattttaaca aaaccaaaaa aggccctttc 1696561 cactggggaa gggccttttt catcatgtta actcctgaga ttcgccgaag ctttctcttt 1696621 ttttggccaa ataaaatagc tggctgtaat gagaaagtca atgcctataa tgacagtcca 1696681 cagtttaaga atgccgctca acgcctcggt tcgggaagag tcattgataa aatagatcat 1696741 ccctgccaat agtcccgcac caattaagta ggccagcaca tgtcttagcc agcctttcgc 1696801 accgtgcttg gcatggtcca ttccaaaacg tttcagcggt tttgttcctt tttttgtcac 1696861 ataatattga aacttttcat ctgcccattg aatcatttgt ttcccataag cgatcgatat 1696921 accgatgtaa acagctgcaa tcccatgggc tgcggtcgct gaggctccgc ggtaaaggtc 1696981 cacaccagtt gccgctaaca agatcaaatc gataactgga gttaaggcaa ggaatagcag 1697041 tcctaatgta tgtcgtttga atacgtagcg tacagcaagc cccaaaacaa tgacaaccca 1697101 aaacgcaatt tcacagaaaa caatcatcca tgcgataccg ttcaatccat tcccctcttt 1697161 tcaatacagt tgtattattt aaataatatg ttaccatctt tgtttttgta acacaactgt 1697221 attataaaaa ttgccctctc atttttttct tgttacaata aagctatgcc aaaacaaatt 1697281 gaccatgaga aaagaagaaa acaaattgca gaagcaacgt ggcgcgtcat tttagaacga 1697341 gggatggagg gagcatcagc cagaaatatt gcaaaggaag ctggattgtc attagaagct 1697401 tgatcggcaa tagttaccct tattatcaag ataagaaaga aaaggatttt tcgctacgct 1697461 caaatccttt aaaaaaacac aaaagaccac attttttaat gtggtctttt attcttcaac 1697521 taaagcaccc attagttcaa caaacgaaaa ttggataaag tgggatattt ttaaaatata 1697581 tatttatgtt acagtaatat tgacttttaa aaaaggattg attctaatga agaaagcaga 1697641 caagtaagcc tcctaaattc actttagata aaaatttagg aggcatatca aatgaacttt 1697701 aataaaattg atttagacaa ttggaagaga aaagagatat ttaatcatta tttgaaccaa 1697761 caaacgactt ttagtataac cacagaaatt gatattagtg ttttataccg aaacataaaa 1697821 caagaaggat ataaatttta ccctgcattt attttcttag tgacaagggt gataaactca 1697881 aatacagctt ttagaactgg ttacaatagc gacggagagt taggttattg ggataagtta 1697941 gagccacttt atacaatttt tgatggtgta tctaaaacat tctctggtat ttggactcct 1698001 gtaaagaatg acttcaaaga gttttatgat ttataccttt ctgatgtaga gaaatataat 1698061 ggttcgggga aattgtttcc caaaacacct atacctgaaa atgctttttc tctttctatt 1698121 attccatgga cttcatttac tgggtttaac ttaaatatca ataataatag taattacctt 1698181 ctacccatta ttacagcagg aaaattcatt aataaaggta attcaatata tttaccgcta 1698241 tctttacagg tacatcattc tgtttgtgat ggttatcatg caggattgtt tatgaactct 1698301 attcaggaat tgtcagatag gcctaatgac tggcttttat aatatgagat aatgccgact 1698361 gtacttttta cagtcggttt tctaatgtca ctaacctgcc ccgttagttg aagaaggttt 1698421 ttatattaca gctccagatc atcgaattcc tgtctgagtt gattgacttg gcaaaagaac 1698481 gagggctaaa caaaccagat aaacaaatac gtgcgcaggc tcagcaaatg atgaaaacac 1698541 agcgcgccta tgatttggag tcgtacactg ttaagcctct ccctgatcct gagacggtaa 1698601 aatgttatta tttccgcaac aaaagcaggt ctttctttgg tgatttagac acttatttca 1698661 ctttatcaaa tgaaaaagaa ccgtttgatc aagctgccta ttgggaggaa tgggagcggc 1698721 aaattcctca tttccacctg gtggatgtcg attcaagcaa ccacttcatg atattaaccg 1698781 aaccgaaagc gtcaacagcc ctgttagaat tttgcgaaaa gctctattca aacaggggag 1698841 tagtgaatgc gaatttcctt aaggctttcc ggaagaaaca tgaagcgagg gaagaaaaag 1698901 aaacagatga attggtgaag cgctgagaaa acacaaacgc cccctctttt aaaagggggc 1698961 gttttgaatg ttattttgaa agtgaaacag ggagactttc taatcctctt aaaaagacat 1699021 tttttctcca ttgaatgtca tcaggtgcaa ccgcaagttc aatatcagga aatctcttca 1699081 aaagtgcttt aaatgcaatg tggccttcca gcctggcaag aggcgctcct aagcagaaat 1699141 gaatgccaaa accaaaagaa atatgtctat taggcgaccg atttatattt aatatttcgg 1699201 ggttctcaaa aaaattcggg tcgcgattgg cagatccgat gcctataaaa atcatgtctc 1699261 ctcttttgat cgaatgcccc ttatatgtaa agtcttcgat ggcccaccga tttgccatca 1699321 taacgacagg tgaggtgtat cgcagcaatt cttcaaccgc tgtagcgatc atttcaggct 1699381 gctgcttgag cttctcacat tccttcttgt gctgcagcaa tgcgagggtg cctgagccga 1699441 gtaagttaac agttgtttca aggccggcta caacgagcaa gaacagcatc gaatagagct 1699501 ctttttcgct taacttgctg ccgttttcct cagcatgcac aagtttgctg attaaatcgt 1699561 cttttggctt tattcttctg tcatggatca gcttagcgat ataatcttta aattcacgaa 1699621 gggcctgatt tgtcagctct ctattacctt cagaggtatc aaccatcgca ttggtccaga 1699681 tttgaaactg tgaccgatct tcttttggga ttcccatcaa ttcagatata acaataaaag 1699741 gcaaagggga agcgaaggat ttcatgatat ccgctttatt ttctttttcc atttcatcta 1699801 aaagctgttc agcaatttgt tcaatgctgc cgcgcagatt ttcaatggtt cggggagtaa 1699861 atgcttgatg aacaagtgat ctcaggcggg tatggtcagg tgtgtctttt gccagcatat 1699921 gatcggatac aaaatcgata tcttcactaa cgttgagcat tttgatttgt tcttggttca 1699981 tcacattttt tacgtctctt gtaattcgat tgtcttttaa aaaggccata caatcatcgt 1700041 atcgggtaat taaccaggcc ggatatgtgg ctccgaaccg ttttaattca aatcggtgaa 1700101 tgggctcttc ctctctaaat cgtcctaaaa ctgaaaaagg attgtgatga aactctttac 1700161 catgcggatg aaacatcaat ttttccattt gcattctcct cgcctaatag ggtaaataga 1700221 tgaatcaaat tgctgaatta gtttacaaaa aacagaatga tttgaaatgt aatcctgtct 1700281 ctaaaactat atatctatct taggcgtcat tcaataggga gaagaacgaa aaaagtgaaa 1700341 aaacggctcg atataaagca gcgcctttga acgaaagctc aaaggcgcta cgctgtatta 1700401 ttttgatgaa agtggctgtc agctgtgctg gatatcaatt gtatatactg cacgatctgt 1700461 tacgaccttc aatccttcgt tttcttggtg aatatgaagc tcacctaata aaggaatctc 1700521 ataggcattt tgcggaagcg gtacgtttcc gtcctcagtg aatgttgttc cttcgccttc 1700581 taaaacaagc tcttctttcg caacataatc atcaggatga ttcgtactgc gtatagccac 1700641 tttttgaagg tggagaacaa tctgatccaa gtctgatatc tcttcatcat gggtcaattc 1700701 accttttcta atatcaagcg tctggccgac ttttgattcc agccattgag aaagctgtgt 1700761 attcgtgtgt gccatcaata ttcctccttt tgatctacac gatactattc ccaattgctg 1700821 catcttttac acgggaaaga gccgccccac tctttatgta tgaaacagtt cgctgttgag 1700881 tgccttgata tagcgtacgg cagaacgctg gaccgattcg tcggcatttt ctttgacaac 1700941 tttagagaaa gcattgtaaa gccggttgaa ttgaagcggt tttactttgg ctgctatttc 1701001 ttcaactttg gaggcgggaa ggggaatgag atttgggtag ctgtacataa agctgaccca 1701061 gtttcgatcc gccgcaaccg taatgatatc tccggtcaat agacagcctt tcccttcatt 1701121 gcccttgctc caatgcaaaa cagcaccgcc tttaaaatgt ccgcccagtc ggtaaaggtc 1701181 cagtcccggc ttcatattga gcgtttcccc tgaccagaag tgaatgtgat tgcttggcct 1701241 tgtcacccat tctttatcat cctcatggat atagatcggc gcctgaaacg cttcagccca 1701301 ctcaacctga gtagagtaat aatgtggatg agacaaggcg atggcttgaa taccgcctaa 1701361 ttcgttgatt tggtcaattg tcttttggtc aagatatgtc atgcaatccc acagcacatt 1701421 gaagccctta tgctgaataa gatgggctgt ttgtccaatc gcaaactctg gttcagtttt 1701481 gatgctgtaa agatgctctt cttccttttt aaggatgttt tgaaggtttc ctttctcacg 1701541 catgtcttca agggttgtcc aagtttgtcc atcgggatga atatactgtc tttcatcctc 1701601 gcaaatcaga cacgagttgg gcggatctac agtctgtgca tgttgcacac cgcatgtatt 1701661 gcagatataa tatggcactt tcttcacttc cttcatctat tttccattat tttaccttat 1701721 gattatgaat attcaaacga aaaaaccggc agttctgctg agagagaatt gccggctttt 1701781 gatgatgttt attggccggg aacggaattt tctgcgttga cagcgcccgc tccgtagata 1701841 ttcggatctt catctttcca tttgtccgtg ccgtttttca aaagctcttt tacttcatca 1701901 ggggtaagat ccgggttttg ctgaagaatt aaagctgcga ttcctgcgca aatcggtgtt 1701961 gccatcgagg ttcctgacat tgtaaagtac tgagacccta cacggcttga cttttggagc 1702021 ttatcaatat aagaattcgg agagcgaagg gaaataatat taacacccgg cgctaaaata 1702081 tcgggctttt ctttcccgta tactgtcggg ccgcggcttg agaaggaagc gacagtatca 1702141 tcatcgctgc ttgcagtatt gttatcgtca agcgcaccta ctgtaatcac cttttcgctc 1702201 acgcccgggc ttgcaatggt ctgcgaatca gggcctgagt ttccggcagc gacacagacg 1702261 acaatccctg cgctccacgc ttcctcaacc gctctgacta acggatcttc ctgttcatga 1702321 tcatatctaa gggcatcgcc cccgagcgac atgctcataa tatcaatcgg ttcatcgggg 1702381 ttgtcctcat tgtattgaat acaccactca acaccctcta taatatctgc taacgttcct 1702441 gaaccctgct tgtttaatac ctttacgccg atgagattgg cttccggtgc aggtccgcgg 1702501 tattgaccgg aagaggatgc accgctgctt gcgacatcac ctgcacagtg tgtgccatga 1702561 ccattatcat cgtacggctc tgttttttga ttgaccatgt ccgcgaatcc gataattctt 1702621 ccttctagat caggatgcgg gtagattcct gtatcgacaa cagcgacagt aacacctttt 1702681 cctgtcaggg tttgcccgtt tctgacgact tccttcgcat ggcttgcttc ggttgccgtg 1702741 tctaaaagcg ctttgacttc gcggtttaaa tacactttac ggatattgct gcattcagag 1702801 agaagggaat gtaatgctga aggagtaacc tcggcgctgc agcagttgat tttgttgaag 1702861 cggcttttta gcttgctgcg tttttctttt tgcagcacct ctccagccat ttgaaagccg 1702921 gtctcgtgac agccttcctc aaattcgata atgactgaca ttttttttct gttttgcaat 1702981 ttggtttcga aaaatttatg caagaagcaa ggagtccatt tgaagggctt gtaaagttgc 1703041 aatacggttt cccgtaacgg ccaatctagc ttgtgagcat ttgctctcac catttgtacc 1703101 atagagtacc caaacatgta ttttcctcct attataaggt tctctgtata ctctatgaac 1703161 agatgatagg tttggtaagt ttgtttgtcc tctgtaagag acagacaaga gtttgttttt 1703221 ctgaatcttt cgcattagat acgatagatt cagaagctga ggaaatcatt ggggattgaa 1703281 aaagaacgtt tgttcgtatt ataatgtgat catatcaaac tgggaagggg agagcaaccg 1703341 tatgaatttc tacttgcacc gatctttgga aagccaaatg ccaatcagca ttatatatga 1703401 agaaagacgg aacgattagt aaaagaacga ttattgtgag acagaaaagc aaaacgaaaa 1703461 tcaaagcatt ttgtttttcg aaacaacaga tcagaacatt tttattggac tctatcctct 1703521 cctgtgattt tgtgagaaca aataagcaaa atctctattc tgcaggccgg taacagctgt 1703581 ccgtctcagc aaccgggcag cctgttacta aaaccctcct taaacctata tacatttatt 1703641 tgccaagtga ggttgttcct accttttttg tctttcctct caaccttttt tcactcttat 1703701 ttgaaatgaa ccgctaataa ccgtgacaat caattgattt tttgaaaccg ggaacttttt 1703761 cactgatgat attgtgtata caatggtaag ataaaaccta ttggctaaac ctcatataat 1703821 gaaccgcgcc attcttatga aaggagttaa acatgagaag atttttacta aatgtcatat 1703881 tagtcttagc cattgtcttg ttcttgagat atgttcatta ctcattggaa ccagaaccat 1703941 caaatcagcc agatacatat tcaaatttca gcagcttggc agagaatgag agcccagccg 1704001 attacgatat ttcatataat gagaaaaaag gaagcaaagt cttaattatg tctccgcatg 1704061 gcggaagaat tgaaggcgga gtaagtgagc ttgtgcgtta tttcaataat gaatactcta 1704121 catacctatt tgaagggttg aagtcccatg ataaccaaac actgcacatt acaagcacca 1704181 actttgatga gccattggca aaaaagaaaa tcaaggagca tcaatatgtg gtggcttttc 1704241 acggatataa aggagagaac aagaataccc ttgtaggggg aacagaccga aagcgggcga 1704301 aaatgattgt gagagccctt gagcggagag ggttttccgc tgagttagcg tcgtctaaaa 1704361 gcggtcttgc tggattgaat gccgaaaaca ttaataacca aggggaaacg gggctaagta 1704421 tccagctgga aatcagccgt gagcagagag aagcattttt tgatgatttt tattataaaa 1704481 atagaaaata cacaaagaac agtgaatttt atgcttatgt cagtgcgatc aaaggtgtcc 1704541 tggaaaaaga gtattcgtaa caagcagatc agaagacaaa ataagagaag atcagtagac 1704601 tgaaatagga taaaaaagga ggcaaaacaa tggcagatca tcatttttat ttaaaagcga 1704661 actggccggg taaccgtaat gatgtcggta cgatcgaaag cggaaacctg atcacatcga 1704721 tttccattcc taaagaaatg gatggcccgg gagaagggac caacccagat gaaatgcttc 1704781 tcggggcggc agcgacctgt tacattatta cacttgcagc gatgatggag agaagcgggc 1704841 tggaaaaaga agacttacag atggagtcag aaggcattgt caacgttaca aaaggagtct 1704901 ttacatacaa aaagatcatt caccgtccct ctgtcgtgct taaacatgat gcttcacaag 1704961 acgacgtcgc attggcgcac aaactttgta aaaaagcgga gtcgtcatgc atgatttcgc 1705021 gtgcaattca aggaaatgtc gagctgcagc ttgaagcctc tgtgaaactg ggtggagaat 1705081 aaagaaaaca gacggtcact cacaggccgt ctgtttttta tcttcagcgt gggctttcga 1705141 ttgatttagc acgaccacgc ctgcaatgac aagcgtgaga ccgaatacac cttttaaact 1705201 gatggtttcg ccaaaaagca aaaacccgac aattgctgta agcgcggtac caacgcccga 1705261 ccatgttgca tacgcgcttg ataagtcaat tgtttttaaa gaaaagctta gaaacgtaaa 1705321 agcagaaaga aatccgacta tgactccggc aatgggccag gcttgtgtaa atccttctga 1705381 aagcttcaac atcgtgctcc caaacacttc agatacaatg gcgagagcca aataaagcaa 1705441 tcctctcatc ttcatcactc ctttacggcc aattaagtaa cacgacccct gatagtaata 1705501 aaagaatccc gataagccct ttggcattca gatcttcctt gaaccatttt actccgatca 1705561 ctgtcgtcag caccgtgcct gccccgctcc aagtcgcata ggagaggctc aggggaatat 1705621 ggtttaaagt cagggacagc atataaaagg cgagggaata gccaataacg accaaagcac 1705681 ttggcttcca ctttttgaag ccatcagata ctttcagcat ggctgctcct atcgattccg 1705741 aacatatggc aatcgtgagg aatatatatc ctatcaacat catgaattct cctcactata 1705801 tttttagatt agaaaaaaaa cttcagctag aaaaatatta gtgtatgcct atgtatgagt 1705861 caagagattc attttcacac acttaaaaag accccttttt aaggggtctt ttgcgtttaa 1705921 taataaaaag ggaacggggc atacggataa taggggtatc cgccatacaa ataaggatta 1705981 aataaagcgc ttcctataag cccgcctgca aggccgccga taaacggtcc tccaaaaaat 1706041 ccgaatggcc ggccaaaccc ataaccaaat ccgggtcttc caaacccgta accgaacccg 1706101 aacggtcttc caaacccaaa tggtctcccg aatccgaacg gccttccaaa tattcttgta 1706161 tcttcagggc tgaaatgctc taactcgttc atgttttctt tcctcctgta ataaagtgta 1706221 gatgatgcag tgtattcacc ctgcccggat ttgattgggc gaatcgagga aaaggaggat 1706281 gtgaacacat tgggcctgta tcagtctgac tggtcaaaag caccgcccca cgcacatgct 1706341 tatcatgtca aaacaacgag agaacagggc cattatcatc tcatcgaagg gtttactcag 1706401 ccggcaaacg gatcaaatac cgatcagcat acacattact atacagggat cacttcattt 1706461 gaaaacggcc attttcatcg gtattacgga atctcaggac cggcgattcc cttagcagat 1706521 ggcacacatt atcatgaaat cgaagaaacg acgtatctgg cctataacga gccgattgag 1706581 atccagtacg gaggggttgt gtacgatccc ggagatgaca gaagaaaaac gcatcgtcat 1706641 accctgaaag gaaagacaag ggaaattgtc ggcaatgagc cgctcggctg gtagaaggat 1706701 gtttaccgat gcaaaaaaag ggcaaaatgg ataggtggtt gtccatgttg aatgctataa 1706761 tggggggaga tttataaaag agagtgatac atattgaata atacgaagca gcccgttgtc 1706821 attttagtcg gaccgacggc agtggggaaa accaatttaa gtattcagct agccaaatcc 1706881 ttaaacgcgg aaattatcag cggagattcg atgcagattt ataaagggat ggatattgga 1706941 acagctaaaa ttaccgaaca ggagatggag ggagtgcccc atcatctgat tgacatttta 1707001 gatccccaag actctttctc tactgccgat tatcaaagct tagtaagaaa taaaatcagc 1707061 gagattgcaa atagaggaaa gcttccgatg attgtcggcg gtacagggct ttatatacaa 1707121 tctgtgcttt acgattatac atttacggaa gaggcaaatg atcccgtgtt tcgagagagc 1707181 atgcaaatgg ctgctgagcg ggaaggcgct gactttcttc atgccaaact tgctgcagca 1707241 gatcccgagg cagcagctgc gattcatccg aataatacaa gaagagtcat tcgcgcactg 1707301 gaaattttac atacgtccgg aaaaacgatg tcccagcatt tgaaggaaca aaaacgagaa 1707361 cttctgtaca atgcagtgtt aattggcctg acaatggata gagacacgct ttacgaaaga 1707421 attaatcagc gggtcgattt gatgatgcag tcaggccttc ttccggaagt gaaacgctta 1707481 tacgacaaga acgtgagaga ctgtcaatca atacaggcga taggctataa agagctgtat 1707541 gcatattttg acggttttgt gacactttcc gatgctgtcg aacagctaaa gcagaactcg 1707601 aggcggtatg cgaaacgcca gctgacgtgg tttcgcaaca aaatgcaggt cacatggttc 1707661 gatatgacac cgcctgttga tatggagctg aaaaaaaagg aaattttcac acatatagca 1707721 ggaaaactcg aactttaatc gaaactgtat gatatagaga atcaaggagg acgaaacatg 1707781 aaaccgatta atattcagga tcagtttttg aatcaaatcc ggaaagaaaa tacgtatgtc 1707841 actgtttttt tgctgaacgg ctttcagttg cggggccagg tgaaaggctt tgataacttt 1707901 accgtattgt tggaatcgga aggtaagcag cagcttatat ataaacatgc gatctcaacg 1707961 tttgcgccgc aaaaaaacgt ccagcttgaa ctcgaataga tcaaaaaatg ccatgtcaag 1708021 acatgaggaa aggctgtcgg gggttcccgg cggccatttt taacatgaat ccacttttgc 1708081 tccaagcttt ttgtgtaagc tgaccatgcc aaggcacggt ctttttttat gagaacaaca 1708141 tacggaagta aaaatggtat attatgtata aaatgaattt gggagtgatc gatcttgttt 1708201 gaaagtgaag cagaactgag acgaatcagg attgcacttg tatggatagc tgtcttttta 1708261 ctgttcgggg cgtgcgggaa tcaagatacc attattgaaa cagacaacgg caattcagac 1708321 tatgaaacgc ctcagcccac ctcgtttcca cttgaacata accattttgg cgttatggag 1708381 gacggctata tcaaaattta tgagtataat gagtcccgca atgaggtaaa gctgaagaaa 1708441 gaatacgcgg atgatgagct tgaataaaat tcacaagcat tcgaatttac aaagcggatg 1708501 ccagccgcta aactaaatac agacacagat caaacagagg gtgaaaacat gaagcataaa 1708561 gtgatcgtga atcattggga agaaatttgc gaagatgatt cttgctatga atacggaaca 1708621 agtatcattg tgaacggaaa agaattaatc agagaagcgt caattatcac tgctttgaag 1708681 gcggttttag aagagatcgg cgcggatgtt gaaatagaag aaacagtaga gagcgaaaaa 1708741 tgctgtgata gcttaagaaa aaaaaatcta gactactaag cagttttttt tcatgttatg 1708801 atatacatcg gctaaaaacg acaccccgag taggacgaga gatgattctc gttctgctct 1708861 cttttttggg ccctaatgag tctgcccgtt tgcctgattt gatcaaaata tgaatttttc 1708921 ataaaaacga atctatatat tgtgtttttg ctagagggta gtatactata tatagtgtta 1708981 gtgatgagag attcatattt tttgataggt cgtgataaaa cgtggtacaa atcatatttg 1709041 attcgaaaac agggaatgtt cagcggtttg tgaataaaac aggctttcag cagatacgca 1709101 aggtggacga aatggaccac gtggacactc cgtttgtttt ggtcacctac acgacaaact 1709161 tcggccaggt accggcatca acacaatcat ttctcgaaaa atacgcccat ctcttattgg 1709221 gagtcgctgc gagcggcaac aaagtatggg gcgataactt tgcaaaaagc gccgatacca 1709281 tttcaagaca atatcaggtg ccgatcttgc acaaatttga actcagcggc acatctaaag 1709341 acgttgaatt gtttactcag gaggtagaaa gagttgtcac aaaatcaagt gccaaaatgg 1709401 atccagttaa ataacgaaat catgatccaa aaagatggga aattccagtt tgataaggat 1709461 aaagaagctg tacatagcta ttttgtagat tatatcaatc aaaacacagt cttctttcac 1709521 aatttaaaag agaagctgga ttatttggtt gaaaaccaat actacgaaga ggaattctta 1709581 agcctttatt cttttgaaga cattaaagaa gtgtttaaga cagcttacgc taagaagttt 1709641 cgttttcctt ccttcatgag tgcgtttaaa ttctataatg actatgcttt gaaaacgaat 1709701 gacaagaaaa aaatcctcga gcgttatgag gaccggatct caattgttgc gctgttcttc 1709761 gctaacggcg acactgagaa agcaaaagaa tatgtaaacc tgatgatcaa tcaagaatat 1709821 cagccgagca caccgacatt tttgaatgcc ggcagaaaac gccgcggtga acttgtgagc 1709881 tgcttcttgc tcgaagttaa tgattcttta aatgacattt caagagcaat cgatatctcc 1709941 atgcagcttt ctaagcttgg tggcggggtt tctcttaacc tgtccaagct tcgcgcgaaa 1710001 ggtgaagcca ttaaagatgt tgagaatgcg acaaaaggcg ttgtaggcgt catgaagctt 1710061 cttgataacg cgttccgtta cgctgaccaa atgggacaaa gacaaggctc cggcgcggcg 1710121 tatttaaaca ttttccaccg cgatatcaat gattttcttg atacgaaaaa gatttctgcg 1710181 gatgaagatg tgcgtgtcaa aacgctttcg atcggtgttg tcattccgga taagttcgtt 1710241 gagcttgcac gcgaggacaa agcggcttat gtattctacc cgcacacgat ttataaagag 1710301 tacggccagc acatggatga gatggacatg aacgaaatgt acgacaagtt tgtcgacaac 1710361 cctcgggtga aaaaggaaaa aatcaacccg cggaaactgc ttgaaaaatt ggcgatgctt 1710421 cgttctgaat caggctatcc atacatcatg ttccaagata acgtcaataa agtgcatgcg 1710481 aataaccata tttccaaggt caaattttct aacctttgct ctgaagtgct gcaggcatct 1710541 caagtttctt catacacaga ctatgatgaa gaagatgaaa tcggtctgga tatttcctgc 1710601 aacctgggtt cgcttaacat tctcaatgtc atggagcata aatcaatcga aaagacagtc 1710661 aagcttgcga cagactcttt aacacacgtg tctgaaacaa cagacatccg taatgcgcct 1710721 gctgtaagac gggcaaacaa agcgatgaaa tcaatcggcc tcggtgctat gaaccttcac 1710781 ggctaccttg cgcaaaacgg cattgcgtat gaaagtccgg aagcgcgtga ctttgcaaac 1710841 acgttcttta tgatggtgaa tttctactcc atccagcgtt ctgcggaaat cgcaaaagag 1710901 aagggcgaaa cgtttgatca atatgaagga tcaacctatg cgacaggtga atacttcgac 1710961 aaatacgttt caactgattt ctcaccgaaa tacgaaaaaa tcgctaatct gtttgaaggt 1711021 atgcatatcc cgacgacaga ggactggaaa aagctaaaag catttgtcgc tgaacacggt 1711081 atgtatcaca gctacagatt atgcattgcg ccgacaggct ctatctcata cgttcaatca 1711141 agcacggcgt ctgttatgcc gattatggaa cggattgaag aacgaacata cggcaactca 1711201 aaaacgtact acccaatgcc tgggcttgca tctaataact ggttcttcta taaagaagcc 1711261 tacgatatgg acatgttcaa ggttgtggat atgatcgcca ctatccagca gcacattgat 1711321 cagggaatca gctttacatt gttcttaaaa gacacaatga cgacccgaga tttaaaccga 1711381 atcgatctgt atgcacatca tagaggaatt aaaaccattt actatgcaag aacgaaagat 1711441 actgggcaag acagctgcct ttcttgtgtt gtttgattaa aggagagttt atagtgacaa 1711501 aaatttatga cgcagcaaac tggtcaaagc atgaagacga ttttacccaa atgttctata 1711561 accaaaacgt gaaacagttc tggcttccgg aagagattgc tttaaacggc gatctcctca 1711621 catggaagta cctcggaaaa aatgagcagg acacttatat gaaggtactg gccggactta 1711681 cgcttcttga cacagagcag gggaatacgg ggatgccgat cgtggctgaa cacgtagatg 1711741 gccaccagcg gaaagcggtg ctgaacttta tggcgatgat ggagaacgct gtccatgcga 1711801 agtcgtactc taatattttc atgacccttg caccgactga aacgatcaat gaagtatttg 1711861 aatgggttaa acaaaataaa tatttgcaga aaaaagcgca aatgattgtc gggctttaca 1711921 aagccattca aaaagatgat gaaatttcac tgttcaaagc catggttgct tccgtctatc 1711981 tggaaagctt ccttttctac agcggtttct attatccgtt atatttctac ggacaaggaa 1712041 aactgatgca aagcggtgag atcattaacc tgatccttcg tgacgaagcg attcacggcg 1712101 tgtatgtcgg tctccttgct caggaaattt ataataaaca gacagaagag aaaaaagcag 1712161 agcttcgtga atttgcgatc gacctcctga atcagttata tgaaaatgag cttgagtata 1712221 cagaggactt gtacgatcaa gtcgggctct cacatgatgt aaagaaattc atccgctata 1712281 atgcgaataa agcgctgatg aaccttggat ttgatccata cttcgaagag gaagacatta 1712341 atccgatcgt tttaaacgga ttaaacacaa aaacaaaatc gcatgacttc ttctctatga 1712401 aggggaatgg ctataaaaaa gcgacagttg agccgctcaa agatgatgac ttttattttg 1712461 aagatgaaaa agagcagata taatatctgc tcttttcggc ttgaaggttc aaatgaggag 1712521 gacgcagtac ccatgggaaa aatggacgaa atgattttag ttgccccgcg cgatgatgtg 1712581 tttaaaaaag aaagcttaac cttccagggc gtgtacagtg aagatagcag agtagcagaa 1712641 atcatggctc agattgaagc ggcctatcgt gaaatgagaa gaggggacgc agaagaagat 1712701 ccgcgtttca agcagccgat accttatgtc gtcattaagc gtgaagatga agtttttctt 1712761 tacgagcggc tggctggcgg cggtgaatca cgtctgcaca acaagctttc tctcggtttt 1712821 ggcggccata tgaacgccat cgaaggggca gcttcatttg ctgaagtctt aaagctgaac 1712881 acagaccgtg agcttgagga agaactgcaa ataaatgaag aagataaaca ggcgattgtc 1712941 acactgggat tgatcaatga tgatgaaaac agtgttggca aagtgcatat cggtattctt 1713001 tctgcgcttc aattaaagcc tggcgcacaa gtggaagtga aggagaaaga acaaattgcg 1713061 ggtaaatgga tgaaagtttc tgaattaaaa caggatgata tctacaaccg tctggaaaca 1713121 tggtcacagt ttgttgttga tattcttgaa taaaaaaacc cggtttctcg cgatgaggag 1713181 ccgggttttt ttatgagacg ctcgtccccg tctcggctat gattctagga tcacaatagc 1713241 gtcaaagccg gcatttttcg ctctggcagc gagggtgtct gcattgtctt tggatgaaaa 1713301 tgcgccaatc tgcactttgt ataatccgtc ctttaaaagg acaatcgagt caaaaccttt 1713361 ggcttcggca ttacttgcga gcgagtcggc attcgctttg actttaaatg cgccgatttg 1713421 aaccttatat aaccctgagc tggaagtctt tttaaggtta aaggcttgct ccagcccgtt 1713481 tgcatgtcct ctcgctaagc tttgaataaa actgctcgtt ttcagcttat ttgcatcgga 1713541 aacggtatca atgaagccgt tctcggtcaa gagggcaggc attgccgact cccttaggac 1713601 gtggaagttc gctgtttttt tgccgcgatc ggcaaagtcg acagcttgta tcacttcaga 1713661 gtgaattgtc gattgataag tcgtcgtcgg ggctcctaca tctggataaa tatagctttc 1713721 aaaacctgtg cctcccccgg aattaacgtg aatggacaaa aagaaatctg ctccccagtt 1713781 atttgcggca tttgtccggt cgtttaagct gacatattgg tcgcttgtcc ggctcagcag 1713841 cagagaaacg ccttcatatt cattagttaa tatcgtacgt aaggctaaag cgatttgcag 1713901 ggttaacgtt ttctcctgaa ggccattacc tgttgcgcct ggatcagacc cgccatggcc 1713961 aggatcaata aaaattttaa ccatttttca tcacctcatt acaggatatg aaaaaacacg 1714021 gcttctgctt gtacgattat cattcaactg aaaaatgagg aaataaccct ttcacatcca 1714081 gaaattattt ctcgggaaag cgcacaattc aacatgaagc gacaacagat acggtccgac 1714141 atgaaatctg tgcatacgcc atatgtttgt atgtactatg ggttcggtta acctgcactg 1714201 attcctgctg gttttaagct ttgcgttcat attaaatcaa gcatttaaaa cgtaaattga 1714261 tgaggaaagc tcctttcatt aaagacaccg ctttataaat cgaaaaaaag aaaaacactt 1714321 caggtatctt agggcgggta atacgtttcg tacaaaaatc agcccgttgt atgaaaaaga 1714381 aataatgaga aagaagctca ctataatact ctgacaaaat gattaaaaac aaaatctcat 1714441 ggtttgtcca ccccatgtcc gtgaatacaa taagaaataa agtatttctc gggaaagcgc 1714501 aggattcctt attgttcccg aaaaaagcaa ttgtttcgac acatgatagg cgtttgtcac 1714561 aatcggcatc cgcttgaata tcatatagag agaacagaga ggtgaagatg ttggagcgcg 1714621 ctgtgactta taaaaacaac ggacagatca acattattct gaacgggcaa aagcaggtgc 1714681 tgacgaatgc tgaggcagag gcggaatatc aggctgcatt gcaaaaaaac gaagcaaagc 1714741 acggcatttt gaaggaaatc gaaaaagaga tgagcgcatt agttgggatg gaggaaatga 1714801 aacgcaacat caaggaaata tacgcctgga tttttgtgaa ccaaaaacgc gcggagcaag 1714861 gcttgaaggt tggaaagcaa gcgctgcaca tgatgtttaa aggaaatccg ggaacgggaa 1714921 aaacgacggt tgcacggctc atcggcaagc tgttctttga aatgaatgtc ctgtcaaaag 1714981 gccacttaat agaagcggag cgggctgacc tggtcgggga gtatatcgga cacaccgccc 1715041 aaaagacgag agatttaatc aaaaagtcat taggtggcat tttgtttata gacgaagcct 1715101 actcgctggc aagaggcggc gaaaaggact ttgggaaaga agcgatcgac acacttgtaa 1715161 agcatatgga agacaaacag catgagttta ttttgatact cgccggatat tcacgggaaa 1715221 tggatcattt tctctcgtta aatcccggac tccaatcaag atttcccatc tccattgatt 1715281 ttccggatta ctctgtgacc cagctcatgg agattgcgaa acgaatgatc gatgaaaggg 1715341 aataccagct cagtcaagaa gcggaatgga aattgaaaga ttacttaatg acagtgaaaa 1715401 gcacgacaag tcccattaaa ttcagcaatg gacgttttgt cagaaatgtg atcgaaaaat 1715461 cgatcagagc acaagccatg aggcttttaa tgggagacca atacttaaaa agcgacttga 1715521 tgaccatcaa aagccaagat ctttccatta aagaagaagc atctggatct gcatagacct 1715581 ctcagttttt gagaggtctg ttttttgctc gtatttccgc ttttcaaagc aatcgatttg 1715641 tggtatacac atgcagggtt tggtatgata atactactgc ccaatatgca aaagaaagga 1715701 acatccattt gaacgaacaa gaaacgattc aggagaaagc cattttagtc ggatgtcagc 1715761 tgccgcatat cacggatgag cattttgaaa attctatgga agagctagca tctctgacga 1715821 aaacagcaga cggaaaagta ctgaccagcg tcacacaaaa acggaacagg gctgacgccg 1715881 ctacatatat aggaaaaggg aaggtagaag agctgaaggc actcgtggaa gagcttgaag 1715941 ctgatctcct catctttaat gatgaactgt cgccaagtca gctgaagtca ttggcaacag 1716001 caattgaagt gaagatgatt gaccgcacgc aattgatatt agatattttt gcaaagcggg 1716061 cgagaacgag agaaggcaaa cttcaaattg agctggctca gctgcaatat gcactgccgc 1716121 gtctgacggg acaagggatc aacctttccc ggcaaggcgg aggaattggg gcaagaggtc 1716181 ccggggaaac gaaactggaa accgaccgcc gccatatcag aaatcgcatt catgaaatca 1716241 acacacagct ttccactgtc attcgccata gaagccgata ccgtgaaaga agaaagaaaa 1716301 acggtgtgct tcaaattgcg cttgtcggct atacaaacgc agggaaatca acatggttca 1716361 accgcctgac gagtgctgac agctatgaag aagacctcct gtttgccacg ctggacccga 1716421 tgaccagaaa aatggtcctg ccaagcggct acagtgttct tctttcagat acagtaggat 1716481 ttattcagga tcttccgacg acattgattg ctgcattccg ctcaacgctt gaggaagtaa 1716541 aagaagcgga tttaattctg catttaattg attcttcaaa tgaggattat gcgggacatg 1716601 aaaaaacagt gcttcggctg cttgaggagc ttgaagcaga tgatatcccg atgctgacgg 1716661 cttacaataa acgtgatcaa aaactgcctg attttatacc gaccgccgga agggatcaca 1716721 ttatggtcag tgcgaaattt gaggacgacg ctgcagcctt taaagaagcg attcagcgct 1716781 atttgcgcca agaactgtta acgtcttttg aagcacatgt gccggcaagt gaagggaagc 1716841 tcctttccag aatcaaatcg gaaacgatgg tagaccgctt ctattttaat gaagaaaatg 1716901 aacagtatga catatccggc tatgtccaag aagagcaaag tatcatcggt gaattaaaga 1716961 agtatatgta ggaaggaaat ataaagacat gtttgacaca ttaacacacg gagaattatt 1717021 gaagaaaacg gcaatggaag tggaagcgga cattgccggc attcataaac aaatagaaga 1717081 aatcagcgag cgaaatgagt ggagagtgct tcaaagctat agaaaacaca aagtaagcga 1717141 cactcatttc acgccgtcta ctggatacgg ctatgatgat atcggaagag acacgcttga 1717201 aagcatatat gcggatgtgt ttggcggaga agcggggctt gtaaggccgc aaatcatttc 1717261 aggcacacat gccatctcaa ttgctttgtt cggtgtcctc agaccggggg acgagctcct 1717321 ttatatcacg ggcaagccgt atgatacgct agaggaaatt gtgggcgtca ggggtggaga 1717381 aaacgctggt tcgttaaagg attttcaaat cggctataat gcggttgatc tgacgaaaga 1717441 cggaaagata gactatgatg cagtcgccgc tgcgatcaat ccgaagacaa aagtaatcgg 1717501 cattcagcgc tcaaaaggat atgcgaatcg cccttctttc ttaattagtg aaataaaaga 1717561 aatgatccgt tttgtaaaag aaatcaatga aaatctgatc gtctttgtgg acaactgtta 1717621 cggagaattt gtggaagagc ttgagccttg ccatgtcgga gccgacctga tggcgggatc 1717681 tctcattaaa aatcccggcg gcggccttgc gaaaacaggc ggctacctcg tcggaaaagc 1717741 gaaatggatt gaagcttgct cataccgtat gacgtcaccc ggcatcggca gagaagcggg 1717801 ggcatctctt tactcgctcc aagaaatgta ccaaggcttc tttttggcgc ctcacgttgt 1717861 gtctcaaagt ttaaagggag cggtgtttac agcgagattc cttgaaaaac tcggcttcac 1717921 ttcaaacccg aaatgggatg cgaaaagaac ggatttaata caatccgttg agttttctga 1717981 cagagaaaag atgattgctt tttgccaggc tattcaattt gcatcgccaa tcaatgctca 1718041 tgtgacgcct tatccagcct acatgcctgg atacgaggat gatgtcatta tggcagcagg 1718101 gacgtttatt caaggagcaa gcatcgaatt atcagctgat ggccctatcc gcccgccgta 1718161 tgtagcgtat gttcagggag gattaaccta ttcgcatgtg aagaatgcca tatgcagtgc 1718221 agtggattca ttgatgcaaa agcaattaat ttaaattttt taaaaatttc tctggatttg 1718281 atgttaagaa tccttacatc gtattgacac ataatataac atcacctata atgaaactaa 1718341 gttaagaaaa ggaggaaatt gagatgagtg ataatattcg ccgctcaatg cctttatttc 1718401 caataggaat tgtcatgcag ttaactgagt tatcagcaag acaaattcga tattatgagg 1718461 aaaatggact gatatttcca gccagaagtg aaggaaatag acgattattt tcatttcatg 1718521 atgtagataa actgttagaa atcaagcacc tgatagaaca aggtgtaaac atggcaggaa 1718581 ttaaacagat tctggcgaaa gccgaagccg agccagaaca aaaacaaaac gagaagacga 1718641 aaaaaccaat gaaacatgat ctgtccgatg acgaactgag acagctcctg aaaaacgagc 1718701 tcatgcaagc cggccgtttt caaagaggga atacattccg tcaaggcgac atgtcccgct 1718761 tctttcatta atccgttagc aactgttttg ctatatacat ttacctttta agaggaggaa 1718821 ttttaccaaa tggcaaagta cactagagaa gatatcgaaa aattagtaaa agaagaaaac 1718881 gtgaagtata tccgccttca atttactgac attcttggaa caatcaagaa tgttgagatt 1718941 cctgtaagcc agcttggaaa agcgcttgat aataaagtca tgtttgacgg ttcttctatt 1719001 gagggattcg ttcgtatcga agagtcagac atgtacctgt atccagatct aaatacattt 1719061 gttatcttcc catggacagc tgaaaaaggt aaagtagcac gtttcatctg tgatatttac 1719121 aatccggatg gcacaccttt tgaaggtgac ccgcgaaaca acttaaaacg gattctgaaa 1719181 gaaatggaag acctcggctt cagtgatttt aaccttgggc ctgagcctga attcttctta 1719241 ttcaaattgg acgaaaaagg cgagccgacg cttgaactaa acgacaaagg cggatatttc 1719301 gacttagctc caactgattt aggagaaaac tgccgccgcg atatcgtact tgagcttgaa 1719361 gagatgggct ttgaaatcga agcgtctcac cacgaagtag cacctggtca gcacgaaatc 1719421 gactttaaat atgctggagc agtccgctct tgtgatgaca tccaaacatt taaactagtt 1719481 gtcaaaacaa ttgcccgtaa acacggcctg catgcgacat ttatgccaaa accattgttc 1719541 ggtgtaaacg gttcaggtat gcactgcaat ctatcactct tcaaaaatgg tgttaacgca 1719601 ttctttgacg aaaacgcaga tcttcagtta agtgaaacag cgaagcactt cattgcaggt 1719661 atcgtgaagc acgcaacaag ctttacagca gtaacaaacc cgacagtaaa ctcttacaaa 1719721 cgtcttgttc ctggctatga agcaccttgt tatgtagcat ggagcgcgca aaacagaagc 1719781 ccgcttatcc gtatcccggc ttctcgcggc atcagcacac gtgttgaagt acgcagtgta 1719841 gacccagctg caaacccata ccttgcactt agcgtattgc ttgctgcagg attagacgga 1719901 atcaaaaaca aactggaagc gccggctcca atcgaccgca acatctatgt gatgagcaaa 1719961 gaagagcgca tggaaaacgg aatcgttgac cttccagcaa cacttgcgga agcactagaa 1720021 gaattcaaat caaacgaagt catggtcaaa gcgctgggcg agcacctatt cgaacacttc 1720081 atcgaagcaa aagaaatcga atgggatatg ttccgcacgc aagtacatcc ttgggaacgc 1720141 gaacagtata tgtctcagta ttaatatctc aatcccttgg cactaaaagt gtcaggggat 1720201 tttttatgtt aataggtaat aaattatgga gcggcactgc taaaaagcag ggtcactttt 1720261 agtctatgtc actaataatt ctatgtacta aatttttaat tagggaaata attccacgct 1720321 taaggaagca atacgcataa ataattcgac aaattctgtg ataattccat tgttcaatac 1720381 ttctaccagc aataataaga tgagtaaggt agatgtttat cattgacatc ataaccaaat 1720441 gaatccataa ttacgttgaa atctaaatca attttcaaaa aggagatttc tatgaaaaaa 1720501 ttgactatct tctccggggg attaggagcg gttttttctg tactggctca actgtttgcg 1720561 gttatagatg actcttacac tttggggaat ttatggtttt taggtgcttt ggcgggaatt 1720621 ataaccatgc ttgcttcaat ccagacaaat aataaaccag tcttcagcat attattaatt 1720681 gctagttcag taataggtct acttggaact ggtcttgtat acatcatacc aacactgttc 1720741 aatataataa taatttataa attttcaaaa gtaagccaat aagccaatgg gaaaattaag 1720801 gttctttttt tatttaacat ccctttgaca aggtcggtga taaatcgcag aatgtttatg 1720861 cttgcaacta atccaccagc gggggcatcg gtgggcatga ttatctaacg ccatgtttct 1720921 aggataccgg aattgaaaca tttgctgagg catttcgtga agctgatcac caaatgacca 1720981 tttccataga ggcacgtcta aagaagctat cataggagga caatactgtg tggaaagctt 1721041 taagtcaatt actcaagaaa cagaaaaatc aaagtccaag cgatgaagat tatatacaga 1721101 ttccagaatt agaagtaaaa gttttgggga tgcttcacag tatcaatata gacctggtta 1721161 atgtaatagc ccaagcagaa aagtctaagg agtttatagg acaaatcgaa ggcatctggc 1721221 attctatagc aaatcaattt tattcactcg cccaagggtt tgagaatgag gatatcaata 1721281 agctttctgc ggatcttgat catgctgccg ccacttggga agctgttgct aataaagcaa 1721341 aagagtttgt aacaaattca taccaagggt aaaagaaaaa taagggcctg aaagggctct 1721401 tttgcttata gtcatatttc ccgtaagtat tactttttgg atttaataaa ttttaaagcg 1721461 tgtttgtttc actgaattca tagtcaaaag gggaatgttt ttatgcttgg aatcaacgtt 1721521 gaaaaatcaa atgaaaactt aattatcaat tggcagctat ccaaaattga aattccaatc 1721581 aaagaaatca atgatgtatt tcttgatcca aactatgggg gagaggagaa aagcgcagta 1721641 aggattgggt ttccttatgg ctcaacagat agggtagtaa ttaaaacagc acgtaacact 1721701 tacattttgt tcaccactaa tcctgcttta attatgagta aaattgtttc ttaataaaca 1721761 gtttatgtcc cttttaaatt tatctattaa tgttctgtgt ggtaaaattt agtgagatga 1721821 tttaaggagg aggagcattt atggaagaaa taaaagttag ttcacatgac actagatggt 1721881 attaagaaag cagtttctaa atatggtaca ttccctatgt ttcatcatgg aggatatgtc 1721941 atggaagatg ctacttttca tttcaaagat cctgctagtc ctcaagaaat tagcgatata 1722001 gaacagaagc taggtgttac tttccctaat gactataaag agtttttgtt acagcacaat 1722061 gggatggaaa tgtttgatgg gattgaaata cttagcttag agggaatcat tgaatataat 1722121 gaggttcaag atttcccaga gggatacgtt ttaattggat atcattttga tggaagatat 1722181 gtcatagaca caaacaaatc aaaaaatgga ttaggctata tgctatatct agactcaatt 1722241 gatgatattg aagatgcgat taacttagat tctaatttcg agatatggtt tgatatgcta 1722301 gtgtctttaa atggaacgaa atattgggaa gtaaatccga atctccaaga gtattataaa 1722361 ctggtttcag aataacactt cggcaaaaga aaaaattatg actaatttca acaaccaaag 1722421 aaactgcaat ttgagggaag tataatgaca atttacgagc aaattaagga tgctttgaaa 1722481 aataagatca atgagttggt ttcacctcaa gaagtaaaga aaacccttca agaaaaatac 1722541 ggaactaatc cggatagcat tattttatca gattattgtt ataaccggta taataagggg 1722601 atttctttta ataagcacct ctttgaatat atgaatagaa gttcttacaa atacttaggt 1722661 gaaaactctc tttatacagg acttattttc agaaaatcaa aaggggaaga taaggaagtt 1722721 atcgtaggcg aatgggtaaa cggtgttaaa tcactccgag aagcttctgt tactaataac 1722781 caaataaatg atcaagccga aatcattagt aaagaacaac ttgtaaacct ttataatgaa 1722841 tataaccaaa tcctgagata tgaaatgaat gtattgaact gtaagcctac agaattgagg 1722901 catttaattg gcagaatcgg tgaattcatt tgtgcaatcc aaaccaacgg cactctggca 1722961 cgtcaaacta atcagcatgg atttgatgtt gtgagtgatg gcagacggat tagtgtaaaa 1723021 acaacagctc aatcaagtgg ttttatttcg ataaataaaa atacatttta tgattttgat 1723081 gatttttttg tagttcaata cgtaaatgat gattttaaag ttattttctt cggctcaaag 1723141 gaagaagtgc aaaaaataag cagaatttat ggaagccaat acgaagttga aatttcactt 1723201 cttaaaaagc ttaataagga ataccaatta aattaaacaa tcttgttggt aacaaacatc 1723261 ctcttactta ttgtaagagg atgtttgttt aattcttaca tattttatct ttgcaatctg 1723321 gcttacgagt tgcatccaca gtaaatgatc ttacttcgtc tttagttttg tcataaattc 1723381 cccatattac ccctcagaga aggatagggg gattattttg gagaatcata ttccattgct 1723441 tgttcacagt cagtaatcct tgagttgttc tagcaagagg caatattgtt gaataagaat 1723501 agttttaaag aggttattgt tgtcttcata ttgaaataaa gattaagtat attagagggg 1723561 agttgcttta atgcacataa caacaaaaag gttattgata cgtgaatttg aattcaaaga 1723621 ttggcaagca gtatatgagt atacatctga tagtaatgta atgaagtata tacctgaagg 1723681 ggtttttact gaagaagatg caaaggcatt tgtaaataaa aacaaaggtg ataacgctga 1723741 aaaattccct gtcatactaa gagatgaaga ctgtcttata ggccatattg ttttttataa 1723801 gtattttggt gaacatacat atgaaattgg gtgggtgttt aatcccaatt atcaaaataa 1723861 agggtatgct tctgaggcag cccaagctat cttggaatat ggatttaaag aaatgaactt 1723921 acataggatt atagctacgt gtcaacctga gaatattccc tcataccgag ttatgaagaa 1723981 gattggaatg agaagagaag gcttttttaa aaaatgtatt ccaaaaggca atgaatggtg 1724041 ggatgaatat tattacgcta ttttagagga agagtggaat tgaactttat tgagtgcggc 1724101 aatacaaaca aattatcacc ctctacttag aacatattag ttaaatgaag gtgatatata 1724161 aagtgatatg acagtgatta aatgggattc aatgagctcc ggtgaattgt ttttaggtga 1724221 gttcactaag gatgatacct gatacgcagc cataccattc gagcgttaat cattttataa 1724281 ctgatctttt cacttttgcc cacgggggaa taagacccta tttaagtttg ccagacgatt 1724341 gtttgatccg ttgttgatga ttgtcaggat tttttgtgaa ggaatatctt tatatagtgg 1724401 ttgattattc ccttctggta aaaattgatc tatgttgaat tgcttaacat gtcattgaac 1724461 tcagagaata aagtgaacct gccacagatg ttcattatct tttagggggt tccaaaaaga 1724521 ccgtattcct atcgatcgct cagagtgaaa atggtatact aaagttacaa tcacaggaag 1724581 gaattacaat ttttttagat ctacataaaa tcatctgatt aaccgaaagt gagaatgtgt 1724641 gaatgaattt aatagggtat attgaggaaa ggtttcaaaa cctcgaatta attcctagca 1724701 tctataatca atggggcaca ggaatccatt tttgtcttgg ggaaaatatc tatcaactca 1724761 aagcaaatga agaattgaat ttaaagatgt ttcggattgt atatgaacaa acctcaatca 1724821 tttttaatga attatttgaa caaaatgatg acatattcct tgtgacgaat atgtataagc 1724881 acaaaaagaa agagaaatgt ataagaaaat taaaggtgta tcaaccgttt ctaaaatgta 1724941 aaaatcattt gaatcaaatt atggtgaaga catatcccta tcctttcgaa atcaataaag 1725001 ctgaagaata cgagatgcaa caattttccc tgttatgcaa acctcgagac ttacgtgtaa 1725061 ctgaattact taaagcagcc agtaatgagg attttccaca aaaaccgaaa ttcggaggtt 1725121 actctattga ttaccctgat gttttctttg tgaacattac aaaagacatt attttcttta 1725181 tctatgatga ccgcggatgc gaagtcatag ctcatgattt caaacgaata cgtccacttt 1725241 atgaaaaata tcacgactgg gtagaagagt ataagtgcat gtaatacttt ttttaaaaac 1725301 gatttatcag gaaaggcaga attagattat gagggcctta catacaagat gtaaacggtt 1725361 attgaaacta agatggtatt atgtgatgat gagagatctg catttttatt agtacttgat 1725421 gaaagattag tggattttga ttctcaaggt ggaaaccata ttagtgttta tttagttact 1725481 cactttgagt tatctgatca atcgtataaa gatgtattaa gctttaatga tgatcttttg 1725541 ggtatggagc ataactgttc gtatgcaatg gatattctaa gcgttaaaga ggaacttgat 1725601 ttcgatttcc catttaatat gcttgcaata aaaagctatg tacaagaatt aataaaaatg 1725661 ttagggattg atatcactct gcctgaaatg aaagaaagag attttgacaa actttctcaa 1725721 aactaaataa aactactatt tttaaagaga acggagactt gctttcaata tgaatgttaa 1725781 aaaagctgca gctgtttttt caatcactat tccaattatc tcagccatct taattattaa 1725841 tttttttaca ggatttatgt caattccatg gcaaggaatg ccggtgtttt ttccattatt 1725901 actttctcct ataggaatca ttttagcgtt cgtttcaata aagacaaata aacggtgtgc 1725961 tgtatatggg attgtcttaa atgcaattat gtttccattt ccttttttct ggtttatcgg 1726021 aggggctttg ttatttggag tttaaaatcc attaggcatt acgcttatac attggtattt 1726081 tcgagcttgt caaaagaagg aataaaaaaa cttcagaatt gcttggcttt actttatgtt 1726141 gaaaggggtc gagtaaggtg gataggaaaa aggatgaaat acaaagaaaa tatagggaac 1726201 aaatgaggga gaagaaagaa cgagaaaaag aagatggcag ttcacatact tttgaaattg 1726261 ttgttgtgct agccattatc attttgatgt ttttctttaa ttcagttttc aaggcttttt 1726321 agatattgta cagatgactt tcaggatgtt tgaaaaaata accctttgag atatataccg 1726381 catgaaagta ttgaaggact tatgaaaatt caagagccag ttgaatctta ataattaatc 1726441 accaaataat ggggatgtaa aatgaagttg tataatgaat ttatcaatat agctaaaacg 1726501 tttaataaag agttagacat aattccatta ttatatggat ctttaggtct tgaaaaggta 1726561 actgggttag acttttcccc agaagatatt gatctcctta ttcctttaat ttttttagag 1726621 gaaaagtggg aaaaactaaa aaaagtgatg gaactgcatg gatacaaaat ggttgattta 1726681 catgagcatg aatttaagaa aactaataca aaaataggca tttcttacat tgaggattta 1726741 aaaccatttg cagatgtaga ctataataac ctagagattt ttgaagatgg cggagcgaaa 1726801 tatcatttgc taacgattga tgattacctc aagatttata aaaagtcttt attagatggt 1726861 tatagaagaa ggaagaagaa tcataaagac caaagtaaaa ttaacatatt gaataaatta 1726921 atacggaatt aatttctgta ttcccttttg tttccagtct caattaaaat ttttaagatt 1726981 aaaataagtt tgaaggaaaa atcatagtgt ttaacacagc cattaatcct cagacagtca 1727041 aatagccatt tctactccgg ttgaaagctt ctctattttt gcttcttatt tatctttcct 1727101 gtattgatat atgtatgtag ggttggactt ataacataaa ctattctggc cattccgttc 1727161 tttcaattca tgaccgggct tgccatcagc ataaatctag gctaacagtc tccatacatc 1727221 ctgtgatcac ctttatcaaa ctcttaaatg caacttacca ctaaccaatt ctttatttcg 1727281 catagatcat ctttgtcatg tgtttacaca agaatctgtt ttggactgag acactgaata 1727341 taacaaaaca gtcaaaaatc aatatttaat tcattctgtt taaactttct gaaaaagatg 1727401 ttgaaaaagt cgaaaggatt ttataatatt aagtcaagtt agtttgtttg atcaacaaac 1727461 taatgaaatg aactttcatt atccacaaga taagatctta ctaatatgga tggaaggggg 1727521 ataagagggt cgatttaatg gagctaaaca atataagaaa cgaaagaatg aggcttttat 1727581 ccttttccag gtatataagg tatgacgaaa aaagatgaat tttttgcttg ctgatcacca 1727641 tatttttttg cactgttttg aaagcgcttt tataaaagtt tactgaccgt aaattcgaga 1727701 aattgttata ccgtttcaca ctgttccata ttaaaggatc gaaaagggga gaaatcatgc 1727761 tcagtgaaaa tgtaaagaag attagcatgg ttgaaaaagt tggatatgcg tctggagatt 1727821 ttgcttgtaa tttaatttat gcaacagtgt ctacgtatct tttgttcttc tatacagatg 1727881 tttttggttt atcggcagca gcagccggta ctatgttttt agtggttaga ataatcgacg 1727941 ctctcgctga tccttttatc ggaacaatag ttgacagaac gaacagcaga tttggacgct 1728001 ttagaccgta tcttttattc ggagcttttc catttgtcat actggcaata ctctgtttta 1728061 caacaccaga cttttcggat atggggaaat taatatatgc ctatataacc tatgttggct 1728121 tgtcgcttac atacacaacg ataaacgttc catatggcgc gttaacttct gcaatgacta 1728181 gaaataatca agaagttgtt agtataactt ctgttcgcat gttatttgcg aatcttgggg 1728241 gacttgtcgt tgcatttttt gttcccttac tggctgctta tttaagcgat acttccggca 1728301 acgagtctct tggctggcaa ctaaccatgg gtattttggg aatgataggc gggtgccttt 1728361 taatcttttg ttttaaaagc acaaaagagc gggtcactct tcaaaaatcc gaagagaaaa 1728421 ttaaatttac ggatatattt gagcagtttc gtgttaatcg tccacttgtt gtattaagta 1728481 ttttctttat tattattttt ggagtgaatt ccatcagtaa ttcggttggc atttactacg 1728541 taacgtataa cttagaaaga gaggatttgg tgaagtggta cggtttgata ggaagtttac 1728601 ccgctttggt cattttaccg tttattccaa ggcttcatca atttttgggg aaaaagaaat 1728661 tactaaacta tgcattatta ctgaatatta taggcctctt agctttactg tttgttccgc 1728721 caagtaatgt ttacctcata cttgtctgtc gattaatcgc tgctgctgga agtctcactg 1728781 ccgggggata tatgtgggcg cttattcctg aaacaattga atatggagag tacaggactg 1728841 ggaaaagaat gggtgggctc atttacgcta taatcggatt tttctttaag tttggtatgg 1728901 ccttaggagg agttgttccg ggtctggttc ttgataagtt tggatatgta gcaaatcagg 1728961 cacaaacccc ggcggcctta atggggattt taattacaac aaccattatt cccgtgttct 1729021 tgcttgttct agctttaatt gatattaatt tctataactt agatgagaaa aaatataaaa 1729081 acatggttcg agaattagag aatagagaca aagtttattt ggatcatatt gatgatttca 1729141 aggcttaaaa aagaaaataa actgaggagg agtcccaaat gaagattacc aatcccgtac 1729201 ttaaaggatt caatcccgat ccaagtattt gtagagcagg agaggattat tatatcgctg 1729261 tatctacatt tgagtggttt ccgggagtcc agatacacca ctcaaaagat ttagtaaatt 1729321 ggcacttagt tgcacatcca ttacagagag tttcacaatt agacatgaaa ggaaacccaa 1729381 attcaggtgg agtttgggca ccatgtttaa gctatagtga tgggaagttt tggctgatct 1729441 atacggatgt taaggtagta gatggcgcat ggaaagattg tcacaattat ttagttactt 1729501 gtgaaacgat taatggtgat tggagtgagc cgattaaatt aaatagctcg gggtttgatg 1729561 cttctttgtt ccatgatacg gatggaaaaa agtatttatt aaatatgtta tgggatcacc 1729621 gtattgatcg gcactcattt ggaggaattg ttatacagga atattctgat aaagagcaaa 1729681 aattaatcgg taaaccaaaa gttatatttg aaggaactga tagaaaactg acagaagctc 1729741 cgcatcttta tcatatcggg aactattatt atttattaac tgcagaagga ggaacacggt 1729801 acgaacatgc tgctacaatt gctcgttctg caaatattga ggggccatat gaagttcatc 1729861 ccgataatcc aattttaacg tcatggcatg acccaggaaa tccattgcaa aaatgtggtc 1729921 atgcatccat tgttcaaaca catacagatg agtggtattt agctcattta acgggacgtc 1729981 ctattcatcc tgacgatgat tcaatttttc agcagagagg atactgtcct ttgggcagag 1730041 aaacagctat tcaaaaactt tactggaaag atgaatggcc ctatgtagta ggtggaaaag 1730101 aaggaagctt ggaggtagat gcaccttcta tacccgaaac aatatttgaa gcaacgtacc 1730161 cggaagttga tgaatttgag gattcaacat taaatataaa ttttcaaact ttaaggattc 1730221 cattcacgaa tgaattaggt tcattgactc aagcgccaaa tcatttacga ttattcggtc 1730281 atgaatcatt gacctcgaca tttactcagg catttgtagc cagacgctgg caaagtctcc 1730341 attttgaagc cgaaactgct gttgagtttt atccggaaaa ttttcaacaa gccgctgggt 1730401 tggtgaatta ctacaataca gagaactgga cggctcttca agtcacgcat gatgaagaac 1730461 ttgggcgcat tcttgaatta acaatatgtg acaacttttc tttttcacag ccattaaata 1730521 ataaaattgt tattcctcgt gaagtaaagt atgtatattt aagagtaaat attgaaaagg 1730581 acaaatatta ttatttctat tcttttaaca aagaagattg gcacaaaatt gacattgcac 1730641 tggaatcgaa aaaattatca gatgattata tccgtggggg aggattcttc acaggggcct 1730701 ttgtagggat gcaatgccaa gataccagtg gtaatcatat tccggccgac tttagatatt 1730761 ttcgttataa agaaaaataa tttgcacatg aaaaaggaga tttctatttt agaactcctt 1730821 tttcatatga gaaggtgcca tgtcactatt gcttcagaaa tactcctaga ataaaaaaac 1730881 tcatctttaa agatgagctg tccattccat aaaaaattac attgtaatca tgtccagaaa 1730941 atgatcaatc acaatggagg acattcctaa tgccggtgca ttctgtccta aggaagatgg 1731001 caataattca tagctattgc ctaattggga ataaaccctt gatgatactt cacttctcat 1731061 tgaatttaaa accataggat gcgattcaat tatgctattt cttaaaatta cggcttgtgg 1731121 gttgaaagta tttagaatat tggtaaggcc tattcctaaa tagaatccaa aattttgtaa 1731181 tgcatttaag gttccgatat cattcagatg ggcgaggttt atgatatctt gataggacag 1731241 ttttttctct ttggtctgaa gagattttaa taaagccttc tctgaagcat acaattccca 1731301 gcatcctcgg tttccgcaac tgcatttagg accattaaag tctattgtca tatgtcccat 1731361 ttctccagag aagccgctta ctcctctata taaatgattg ttgataataa caccgatccc 1731421 tattcctgtg ctgatactta cgtaaataat gttatcgtga ttttttgcag ctccaaatac 1731481 tttttctcca tatgcgccag catttgcctc attttcaata aaaacaggca cattgtactt 1731541 ctcttgtatc gaagatttta agtcaatatc tctccagttg gagttcggag tgaaaacaat 1731601 tttttgatct ttatcaatga gtccaggcac gcaaatacct ataccaataa gcccgtacgg 1731661 agattggggc atttgcgtaa taaagtgatg aatcatatca atcaaaatgt ctttcgttat 1731721 ttctggagaa ttggattcca aatggcggta ttgatcaaga acgattgttc cttcaaggtc 1731781 tgttaaaatg ccattaatat aatccacacc aacatctatt ccaacggagt atcctgcctt 1731841 tttattaaaa acaagcatga caggtcttct tccgccactt gattgtcctt gacctatttc 1731901 aaataccata ctttctttca ttaacgtgtt tacctgtgat gagacagttg atttatttaa 1731961 tccagtcatt tcagataatt ttgctcttga aataggtgaa tttttaagga tttcttttaa 1732021 taataacttt tgatttactt ttttgacaaa ggtttgatca gcgatatcca cttcatccac 1732081 tccatttgtt taatctttaa attaagtatc aacatagtac atagcgaatc ttccctttat 1732141 tatatctaat gtgttcataa aaaactaaaa aaaatattga aaatactgac gaggttatat 1732201 aagatgaaaa taagttagtt tgtttaaaca acaaactaat aggtgatgta cttactatat 1732261 gaaataaaat gcatctgtat ttgaatgaat ttatttttaa gggggaaatc acatggctca 1732321 atctcattcc agttcaatca actattttgg aagcgcaaac aaagtggttt acgaagggaa 1732381 agattcgact aatcctttag catttaaata ttataatcct caagaagtaa tcggcggaaa 1732441 aacgctgaaa gagcatttgc gattttctat tgcctattgg catacattta ctgctgatgg 1732501 tacagacgtt tttggagcag ctacgatgca aagaccatgg gatcactata aaggcatgga 1732561 tctagcgaag atgagagtag aagcagcatt tgagatgttt gaaaaactag atgcaccatt 1732621 ctttgctttt catgaccggg atattgcacc agaaggcagt acgctaaaag agacaaacca 1732681 aaatttagat atgatcatgg gcatgattaa agattacatg agaaatagcg gcgttaagct 1732741 attatggaat acagcaaaca tgtttacgaa tccccgtttc gtccatggtg ccgcgacttc 1732801 ttgcaatgca gatgtgtttg cgtatgctgc agcacaagtg aaaaaagggt tagaaacagc 1732861 aaaagagctt ggcgctgaga actatgtatt ttggggcggc cgtgaaggat atgaaacatt 1732921 gttaaatacc gatttaaaat ttgagcttga taatttggct agatttatgc atatggcagt 1732981 ggattatgcg aaggaaatcg ggtacacagg gcagtttttg attgagccaa aaccaaaaga 1733041 gccgaccacc catcaatacg atacagatgc agcaacaacc attgcctttt tgaagcaata 1733101 tggcttagac aatcatttta aattaaatct tgaagccaat catgccacat tagccgggca 1733161 tacattcgaa catgaattac gcatggcaag agtacatggt ctgcttggct ctgttgacgc 1733221 aaaccagggt catcctcttt taggctggga cacggatgaa tttccgacgg atttatattc 1733281 tacgacatta gcaatgtacg aaatcctgca aaatggcggc cttggaagcg gcggattaaa 1733341 ctttgacgcg aaggtcagaa gatcttcttt cgagcctgat gatctaatat atgcccatat 1733401 tgcagggatg gatgcatttg caagaggatt gaaagttgcc cacaaattaa tcgaagatcg 1733461 tgtgtttgaa gatgtgattc aacatcgtta ccgcagcttt actgaaggga ttggtcttga 1733521 aattatagaa ggaagagcta atttccacac acttgagcaa tatgcgctaa atcataaatc 1733581 aattaaaaac gaatctggaa gacaggagaa attaaaagcg atattgaacc aatacatttt 1733641 agaagtataa caggataagc tccagatcct gctatcaata ccaagtcact gaattacccg 1733701 tcatgattcc tttcctattg cttgttgtta tgacgggtaa cttctataat taggatttat 1733761 ttagagtgaa tggtttttta aaagggcaag gagtgaaaaa atgaagtatg tcattggaat 1733821 agatcttgga acgagtgctg ttaaaaccat tttagttaac caaaacggca aggtttgtgc 1733881 agaaacgtcc aaaaggtatc cgctcatcca agagaaggcg ggatatagtg agcaaaatcc 1733941 tgaagactgg gttcagcaaa caattgaagc attggctgaa ttggtttcta tatccaatgt 1734001 tcaagccaag gatattgacg ggataagcta ttcgggacaa atgcatggat tagtactgct 1734061 tgaccaagat cgtcaggtgt tacgtaatgc aattctttgg aatgatacca gaacaacgcc 1734121 tcaatgtata aggatgaccg agaaatttgg cgatcatctt cttgacatca caaaaaaccg 1734181 tgttttagaa gggtttacat tacctaaaat gttatgggta aaggaacatg aacctgaact 1734241 ttttaaaaaa actgctgtgt ttttgcttcc gaaagactac gtgcgattcc gtatgaccgg 1734301 tgtcattcac accgaatact ccgatgcagc aggaacttta cttttacata ttactcgcaa 1734361 ggagtggagc aatgatattt gcaatcaaat tggtatttct gcagatattt gtcctccgct 1734421 tgttgaatct catgattgtg taggatcgct gcttccgcac gttgccgcga agaccgggct 1734481 attagaaaaa acaaaagtgt acgctggggg agcagataat gcttgcggcg ctattggagc 1734541 aggtatcctt tcttccggaa aaacattatg cagtattggg acgtcagggg tcatactttc 1734601 ctacgaagaa gaaaaagaaa gagactttaa agggaaagtc cactttttta atcatggaaa 1734661 aaaggattct ttttatacga tgggcgtcac gctcgctgca ggatacagct tggactggtt 1734721 taaaagaacg tttgcaccaa acgaatcgtt tgagcaatta ttgcaggggg tggaagctat 1734781 tccgatagga gccaatggac tgctatacac tccttatttg gttggtgaaa gaacgccgca 1734841 tgctgattct tctattcggg gaagcttgat cggaatggat ggagcccata atagaaagca 1734901 ttttttgagg gcaataatgg aaggtatcac attctcttta catgaatcaa ttgagctatt 1734961 ccgcgaagcg ggaaaatcag ttcatactgt tgtttctatt ggtgggggag ctaaaaatga 1735021 tacgtggctg caaatgcaag ctgatatttt caatacgagg gtaattaagt tagaaaatga 1735081 acaagggcca gctatggggg ctgcaatgct ggctgccttt ggaagcggtt ggtttgaatc 1735141 acttgaagaa tgtgcagagc agttcattcg tgaggctgct gcattttatc caaaggcgca 1735201 aaatgttcaa aaatataaaa cactatttga tttgtataag aacatttaca ctcacacaaa 1735261 ggatctcaat acagctttga agagctttcg aaaaaactaa tgatgttatt gtctggagat 1735321 caaccgaaga acaattaatg atcaatcatc atcaaaggcc tttgataaca tggctgcctt 1735381 cttttgaaaa gatggtgaga ataaggtatc gcaaccttta aacagtattg gagtatccag 1735441 cagacaaaac gaacgagtgg aaccgtattt tgtcagcgaa cacttcaaga agtggggaag 1735501 cttaggaatg ccaatgggta agatgtatga aaccgcgcta acgacggtag agggatctct 1735561 tgatttatga agaaatagga aggatgttaa cacacaaata acccctcaca ttgacgtgaa 1735621 ggggtgtttt ttattgttac tatacagcgg aaattttaca ggctagttgc atgattttag 1735681 cttgttaagc agaatggaac tagactctcc atcatctctt tctcattctt tggaaactgc 1735741 attctgctag gtttgctgct ttttttaaca aacagtgttt ttctatttca cacagccatt 1735801 aaatcctctg ttcgtcacat aaccgctctt actccaaatt gacagtttat ctgattttgc 1735861 ttcttgctca tctagtctga attggtctat gtattttgtg ttaggctcat atacatatgc 1735921 tactctggcc aatccctctt tcaataatgt ctcttgaaca gatttgccgt caacataaac 1735981 gtatgctaac agtcttccat acttatctct gcgatcgcct ttatcaaatt ccagctgtag 1736041 cttaccgctg ttgaccaatt ctttatttcg tttcgacgca tcctcaccgt atggttgaac 1736101 acaagaattt ggtttcttcg tctcaggtgt atcaacgagc aagtagcgaa ctgtgtcttt 1736161 ctttccgttg taaataacct taatcgtatc tccatctatt gctctatcta atgtaacatt 1736221 gaccaatttc ttctgatttt ttgaatgagg cgtgccagcc ttttgttctg tctgattata 1736281 ttcattagag tgagtatctt gagagacttg ctccgtccca ttagaatctg aatggttttt 1736341 ggctgcgtga tttgatccgc aagctgccaa agtaatactt aaaacgattg cgatcatact 1736401 gatcaaaatc ttcttcatat tgattccctc tttatcattt tctcttttcg cgattaaaca 1736461 tcatcattat aacgatatgg acattttttg tgaatggaaa acttcaaggg aacttataac 1736521 actccaaatt gccaatagtt aacttcacaa cgagatgatc aaaacatcac catcacatag 1736581 cggaaataaa taatcctgaa aataatattg actgaaaatg cttttagaat tatgataata 1736641 tgagaaatga caataatgtg acaaagacat tactacaaca taacaactaa tagcttaggt 1736701 ttattctatt ggttaaaaat gtaaacggtt acaaatccag aggcgaaaat ctaagataga 1736761 gatgacttta gttttgactc aatatccaca ctgaaagagc ttattaagta ttcttaaagg 1736821 caggggaaat ggatatgaat gaacatcgaa atcgaaggtt gaaattaata atgatttcag 1736881 caacttttgg agggcttctc tttggatatg acaccggagt tataaatgga gctttacctt 1736941 ttatggcaag gccagatcag cttgatttaa cacctgttac agaagggctt gttacgagta 1737001 ttcttttatt aggtgccgcg tttggagcgt tgttatgcgg aagattggct gatcgatatg 1737061 gccgccgtaa aatgatcctt aatctttcct ttttattttt cctggcatca ctgggaacag 1737121 cgttagcacc taatgttttc atcatggcgg tctttcgttt tttactgggg ctggctgttg 1737181 gaggagcctc ggcgatggtg ccggcctttt tagcagaaat ggcaccgcat gaaaagagag 1737241 ggcgtatggt aacccaaaat gaactaatga ttgttggcgg gcaattttta gcatatgttt 1737301 ttaatgcgat cctcggtgta acaatggcaa atacgggaca tgtttggaga tacatgctag 1737361 tcatttgtgc tgtaccggct atcatgttat ttgccagtat gcttaaggta ccagaaagcc 1737421 cccgatggct aatctccaaa ggcaaaaaca gtgaggcgct gcgagttctt aaacaaattc 1737481 gagaagataa acgtgcagaa gctgaatgta gagaaattca agaagcggta gaaaaagata 1737541 cagcactaga aaaggcatca ctcaaggact tttctacacc atggctgcgc cgtcttttat 1737601 ggattggaat cggtgttgcc atcgtgaatc aaattacagg tgtgaactcg attatgtatt 1737661 atggcacaca aatccttaaa gaatctggtt ttggtacaaa agcggcttta atcgctaata 1737721 ttggaaatgg gctgatatca gttattgcag ttatatttgg gatttggctg gtcggaaaag 1737781 tgagacggcg tccaatatta ttgattggtt tggcagggac gactacagcg ctcctattga 1737841 ttgcgatttt ctcaattgtg cttgatggat ctatggcact tccttatgta gtgctttctt 1737901 tgaccgtttt atttcttgcc tttatgcaag ggtgtgtagg acctgtgact tggcttgtca 1737961 tagcggaaat attccctcaa aggttaagag gacttggttc tgggataagt gtttttttcc 1738021 tttggatatt aaactttgtg atcggttttg ctttcccgat cttgcttagc tctgtaggtt 1738081 tgtcttttac attctttata tttgtggctt taggtgtatt ggcaatcggt tttgtgtaca 1738141 aattcatgcc ggaaacaaaa gggcgtacac ttgaagaatt agaagagcat tttcgttctc 1738201 gacacgatca taatactcct gaacaatcag ttattgaggt ataaatatgt tgaaaatctc 1738261 tcttcttata ggagggattt ttttagtttc agaaaaaaca aaatccctct ggtagaggga 1738321 ttttgattca gcattttaag atgttctaca cgtataatac tggagttgat actttaaaaa 1738381 tctcgccatc tcttatataa aaacgaggga tgcggcggct taatgtagac acgacttcat 1738441 agttaatcgt attgagcatt tcagccactt catcaacgga aatctcggct cctttttgct 1738501 taccgtaaat cacgacttca tctccttgtt taccttcacc gttttctcct aaactgacca 1738561 tgatcatatc cattgttact cttcccgcca ctggcactcg ttttccgcga tgaagaacaa 1738621 acccgcgatt ggaaagggca cgagaatagc cgtcagcata gccaatcggg agtgtagcaa 1738681 ttacttcatt aggttctgcg atgtatgtag caccatagct aacggttcgg ggttctgtcc 1738741 gcatggtttt cacataagcg atgcgtgcct ttaaacttaa cgcaggttca agcttaacga 1738801 gatttagttg tttaatatag gctgaaggat ataaaccata taagccgata cctaaacgga 1738861 tcatatcagc gctaaattcc ggaaatgcga tagctgcagc cgtgttgcac atatgcacgg 1738921 tgggcagctc aatcccctgt ttttttaaaa agctgagaaa actgatgaat ttttcatgct 1738981 gcagctttgt gagtgttgtg tccggttcat cagctgtcga aaaatgtgtg aaaatccctg 1739041 tccatctgag gaatttactt gcctttaagg ctttcactac ctctaaaagt tcttcctttg 1739101 tgcgtacacc taatcgtccc atgccggtat ccacgttaat atgaatggcc agccggttag 1739161 cactcgcttc tttttccaat atctcgtttg cttctttcat ccaatcaacc tgaaatgctg 1739221 ataatgttat attccaagct gctgacttct ttacacaact aagggatgta aaaccaagca 1739281 caaggatagg tgctgtaatc ccagctttac gtaaaacgat tccttcctcc acactggcaa 1739341 cagcgagctc actcgccccg tgttccagtg catggcgtgc cacttctata gacccgtggc 1739401 cataaccgtt cgcttttaca acagccataa ttttgctctt atgtggaata tgacggcgga 1739461 tcgctcgcaa attcttttta acggcatcaa gattgacttc gatccaaact tctcggcaaa 1739521 gctttatcat caacgcttcc ttccttctta tggattataa ataccaccta ttgccgcaag 1739581 aataaatgtt aattgttgga tgattcgatc ttattttatt caactttatt tgaaatcatt 1739641 caacagcaaa tccatgtgat acgagaaggt gcctatcaat gttcgaataa tagcaagtac 1739701 gggatacatg aggcttgtaa gtggggtgtt aatggatgcg gcgaccgagg attacaaaaa 1739761 tgattatttg ttttgggaca tttttttcta agggtagatg ataacgagaa atctaatcag 1739821 gaaatactta ccgttgttat gaacattgaa gaacctttta aatgagaagg gctgaggaaa 1739881 ttctgtaaaa gataatcggt tgaaaaggca gtcgattcct tgttccataa acctaacatc 1739941 agagtatata attatactcg tattcacaaa aatcgtttaa gtaaggggta tacatgaata 1740001 ggggagttag ttttcaaata ccgaatgaat atggaaattt tctatggaga atactgcagc 1740061 cggtagaaat agctaattat aggtggcaaa cgagtgggga atcttatttt gttgtagaag 1740121 gagagctcga tgatgaggag ctttttcatg actacgaaat tgttgagggg gcagtttttg 1740181 agcaacaatt aaaaacgaat cagtactata ccattttcgt tgaactgaaa gcatttccat 1740241 atggaaaaat ggttaatcaa gtcaatacat atgaagagtt tgctgacagt gattgcgaac 1740301 ttgtcctttt gatagcagat aatagctacg tttcgattta ctgtaaaaac aaaaatatca 1740361 ttgaaaaact ttacttcaat gctttacagc atgattttga agacgttcaa tttataactg 1740421 atgaaaatga cacaagaaca agccttactg tatgatactc aataaaaatt aaaggagcta 1740481 gtacatgaca atgcaaatta aaatcaagta tctagatgaa acacaaacaa gaatcagcaa 1740541 aattgagcag ggagactgga ttgatcttcg ggcagctgaa gatgtaacaa tcaaaaaaga 1740601 tgaatttaag cttgtcccat taggtgttgc aatggagctg cctgaaggtt acgaagcaca 1740661 tgtcgtccct cgttcaagta catataagaa ctttggcgtt attcaaacaa attcaatggg 1740721 tgttatcgat gagtcatata agggagacaa cgatttctgg ttctttcctg cttatgcatt 1740781 gcgtgatact gaaattaaga agggtgatcg tatctgccag tttagaatca tgaagaaaat 1740841 gccggcggtt gaattggttg aagtcgagca tttgggaaac gaggatagag gaggactcgg 1740901 ttcaacaggt acgaagtaaa caaaataaat ccttggctgt cttcatgctg tgtgattgat 1740961 caatggaggt ttcagccaag gtacatataa atattatgta taaaatgaat attttaatac 1741021 gaaggattta attaaaaaca aagtttaaaa agggaagttt tgaaaaagtg aaatagtaat 1741081 aactaaagtc gataaagaac ctaaagatgt caaagaaaca atttttctgg tgctttgctt 1741141 ttttgaaggt ttacttagct cgtggataac tgccccccat aaaagcatgg atgctaaaat 1741201 tataatactt atatacataa agatgctcct tttattatat ttacagtttt tacattttta 1741261 tcgattttac cacatttagg attgagttgt cgatgaaaca agcatctcta taaagaaata 1741321 cttttatcta aatttttata aataggggaa ggcaactaaa aactagtaat gccactaata 1741381 ataagccaag ttaaatgact tgtgttcatt aataattgaa ttttacagca gccatgagca 1741441 caaaaaaatc tgagttcgtc gataaatatc ataaaaaagc ccccggtatg tcgccaggga 1741501 ataaatagac gtttaagaga tttagtgatg ttttttatat gattcgacaa aatcataata 1741561 atgatcatcg tcatcataat actttttttc gtaatgataa tcgtgatcat cgtaatactt 1741621 tttatcatgg tcatcatact ttttgtcgta atcataatgt tttttatcat gatcataata 1741681 cttgtcgcaa tcataatgct tcttatcatt gtcgtaatac tttttgtaat atgttttttt 1741741 ccaagtataa tactcttctt tatatttttt ataataaccc aattaaattc ctcctttatg 1741801 ttattcgaat ttaatttatg aagtttaaat gatatggtat ggtcaaatga aataagaata 1741861 gtaaaaagag gctgtttaaa acactttctg aaaaacaaaa cggatagctg tttatgaaaa 1741921 taagagcgag agagagcact caatcactgt aaaataatag taaagtgtat agagagatta 1741981 gtatacgtaa aaagggactt tctcattgaa gaatatttga acgttatggt taagattcaa 1742041 gagctctatg atgtgatttt tcacactgct tttgaaggat ttagagttag acatcaaaaa 1742101 caaacagcaa aaccggctag aaacagatca tataaggaat gaaccgctgc caaatatcat 1742161 aaaaaagttg ttaatgatca aatgaatgaa attagagaga atttatttta aagaaagccc 1742221 aattgcacat ggacaaatga caattgatat tgaggtaaaa tacaatgcat taaatcagaa 1742281 aaagctattg gaggatttaa tgtgtttaga caatttccaa tttggtatac acaaacacct 1742341 gactatttga atttttatgt accgcaatat caaaccattt cgtataatcc tcaacaatgt 1742401 tatcaacggt gtatgtacca aactggcggt aactatgagc tatgtgacag actatgttat 1742461 ggagaaatac aggtgtaaaa gagggggatt aactcctctt taaacacaca gtgagtggaa 1742521 taagatcctc actttatctg caagtgctta gtatttgcga taatattgca ttcgtaataa 1742581 attatgctta gcaactgaaa atgaaagaag gatatgaata gtcatgacgc aattcgataa 1742641 acaatacaat tcaattataa aggatattat caataatgga atctcagacg aagagtttga 1742701 tgtaagaacc aagtgggact cagatggaac accggcacat actctaagtg taatcagtaa 1742761 gcaaatgaga ttcgacaact cagaggttcc gattttaacg acaaaaaagg ttgcctggaa 1742821 aacagccatt aaagagttgc tctggatttg gcagctgaaa tctaatgatg ttaatgattt 1742881 aaacatgatg ggcgtccata tttgggatca gtggaaacaa gaagacggaa ccatcggaca 1742941 tgcatatgga tttcagctgg ggaagaaaaa cagaagtcta aatggagaaa aagtggatca 1743001 ggtagactat cttcttcatc aattgaagaa caatccatct tcacgcagac acattacaat 1743061 gctgtggaat cctgatgaat tagacgcaat ggccttaacg ccatgtgtat acgagacaca 1743121 atggtacgtt aaacatggga aactccacct tgaggtaaga gcacggagca atgatatggc 1743181 attgggaaat ccattcaatg tattccagta taatgtgttg cagcgcatga ttgctcaagt 1743241 gactggttat gagcttggtg aatatatctt taacattggg gattgccatg tgtacacacg 1743301 tcatatagac aatttgaaaa ttcaaatgga aagagaacag tttgaagcac ctgaactatg 1743361 gatcaatcct gaagtgaaag atttttatga ctttaccatt gatgatttca agttaatcaa 1743421 ctataaacat ggggacaagc ttttatttga ggtagcggtt taatgctgcc tttttattgt 1743481 gcagtgaata gatagcaggt atcctaattt cattaagcaa tctggaagat gaataaaaat 1743541 tgaaggacaa acacgtataa tacataaaaa agattaactc tacagttaat cttttttatt 1743601 cagaagaaaa tatcctaact ttgaaactaa atacaaagta aaagcaatca ttacagttct 1743661 agatattaca attccatgaa tagctagatc atatccagca ggtatcaacg catttgtatt 1743721 acacataaaa tatatagata ttagaagtgc tacaataact aaaatcattc caaaaagact 1743781 tgttttttca tatttcatac caatttccac ccttattaaa gttaggttta aacaaaagag 1743841 ctgaagaaac gaactatgac cagtatgctc caaggaaaac cgccagacaa tgctggcggc 1743901 tttttgctgc ttcgtttatt tattaacaga gatcgtaacg ttatttcctg caactgaaac 1743961 ctttgcgaaa tcctgtgtat ctaccacagg agtgacggct ttattgtcga tagtgatgtt 1744021 gttaaaagag gtcgaaaagg ttgctttgat cgcatcacgc tggctttcat acgaaacagc 1744081 cgcggtagca agtgttttcc attttgaaat cgtgccgatg ttggttcctt gaatttctgt 1744141 gataatccgt ccggtgtagc cgtcattgtt cgttccccaa agggtcatgc gcgtattgcc 1744201 gcttaaattt ttatagattg tcatttggac tgtgcttcca gggcggaagc ctttattgta 1744261 tgtgaatttg tcttttcctt cgatgtacgt ttcttcattt ttggacccaa ccttcatgag 1744321 gggcttccag acgttgtatt gtttgctgta ctgaagcccg atatcggctt cagttccgct 1744381 tgttgcccta aagccagaat aaatataggg agtagagacc gagtcgttgt ttttgacagt 1744441 ttcaggaagc acgattttag ctgtaaaaac ggcgcccgta ctgttcaggt agacacggcc 1744501 gccgattccg ttaggcagct cggatgctgc ttttgcgact tgagcgtctg ccgcgggtaa 1744561 acctggtata cctgatgaaa gggttccgaa aagaactgct gttcctactg cacctgcaat 1744621 caatactttt ttcaccaaaa ttcccccttt tgatagtggt ttcgccattt attatacctt 1744681 attttggaac tggatttacg tatataaatc gacaaaatat ttcattttga atgatgtaag 1744741 gtcgaaacgc ttcgccaatc tgaaagctat atacctttat cagaggaaag aatgagatca 1744801 cattcgtttt aaccgatttg aaattttcct caaaataaaa gtacaaatgc ttaaagaaac 1744861 gattattaaa agaatgcccg ctatcgtttc caagcctgta aaaaagaggt gacgtttcat 1744921 caatgtctgt ccttgtaaaa tgataaaagc acagataccg actaagaaaa gaaaacaaat 1744981 acttaggatt gctaacgctt tacgtgagta tgttttcatt tcatctttaa aatacagcaa 1745041 tacgaaaata aagcagataa cattggctat tgttctaatc acctcaaagc ttttcatgac 1745101 aactgatata aatagacaaa gtaaaatgag ataaaatacg atgtttctat acaaaaaacc 1745161 tctcctttta tgtaggatcc tcaaagagtt tataaaagtt tctttgtaac tgcaataaat 1745221 tgaatgcgct cacttatgaa ctaactaaac tatgtactaa atattcacta ttctttttca 1745281 gattcagtca ccaaggtttt catagaaagg gaagcttcag aaatatacat atagtgcaca 1745341 aacaaaaaag acccggcaat agccggggga aagtaaaaac gaggagatgt taatggcgtt 1745401 tagtagtgtt ttttatgctt tttatactct acaacataat catagtcttt tttatcgtga 1745461 tcataatatt ttttatcata gtcatcatat tttttgtcgt aatcacagtc ataatctttt 1745521 ttatcatatt cgtaatactt cttataatac gtttttttga ccgtataata ctcttctttg 1745581 tattttttgt aataacccat atatactcct cctttatttt tactacgctt tattatacgg 1745641 cgagtagatt ttgcggcttg gacagttaaa atcatagaag gaaaaaaggg ctgtccaaat 1745701 gatagaaaaa gacagatgac acaaaaacaa atcaaaataa agagccgatt tttcatcggc 1745761 ccaaacgatt tatcctacat ttgtttgtct tctttgtttt ctgagtcatt ttttctgata 1745821 tcctgagtca gtccgcttgt tgcttgttta aattctgata aggcttttcc tgctgcacgg 1745881 ccaagcgccg gcagtttatc aggcccaaat actaaaaaac ccacaaacaa aataacgagt 1745941 atttttgtga agcttaattc catatccttt tccccctgat tgaagtacaa ccttttaaac 1746001 aaattataag agatagcagt acaaatggga atgcatttat tttgaacatt ttaaaaccag 1746061 cacaaagacg gattcataaa acggctgctg ctgaatataa tgtccaatgc cacctgccta 1746121 agaagcagga ggcaggctgg atcaattatg tagctctgcc ggaaatgata caaacgtagc 1746181 ggctatcatt gacatagagg agtggtgtag ctgatgagat tcactaaggt agttggattt 1746241 ttgtctgttt tagggttggc tgcggttttt ccattaacgg cacaagcaga aaaagccgga 1746301 actgcggggg ctggagagtg ggataagttg gggacttaca catatactta ctcaagtccg 1746361 acggtatact cgaccggagg agattttaga gtgtgccttt caggaagcac tcctttttct 1746421 gtttcactgc acttatatga ggatgatccc ggtgacaatc ctgatgatta tgtaggggca 1746481 aactattttt cacccggaga atgccacacc tttggcagta ttggaaaatt tgtagatggg 1746541 agcaataaca aggccgagtt ctttgttacc gattactctg gtaaatctaa aactgttacg 1746601 ttttatgatt gatggactca aattgtgaag tataaccctt ggaaaaaaac aaaaaagaga 1746661 gatacctctc tcttttttat tcttcgacag ccttacgaag ccgttcattt acaatgccag 1746721 tccagccgcc atccatctta ccgcgaacga cggagctttt ctcgtttgct ttgccgatca 1746781 cttcattcgg ctctttccag ccgctgtgaa taagggtaaa ccctgtcttt tcccccaagt 1746841 cttctaattg aaaggtaacg acccatcctt ctgtatccca ttcaaaagaa agttcagttg 1746901 gagcttgaac agccaaaact ttacaagggg acggcccaaa cggcgattgt aagtgaaatt 1746961 cttgtccttc tttgagctga aagtcattgg gcataaacca cttggcaatg ccttctgaag 1747021 tagagactgt ctcccagact ttctgaatgg gagcctccag agtaatgctt tttgtaatat 1747081 ccggtaatgc attttcgttg ttttgagcca tttcgtttac ctcttgacat atgatgtttt 1747141 ttcaattcaa tcatataata actaataaga tcatgtccat agcgtgcatt atttatgcta 1747201 gagctgctgt tgaacagcgt gtcagtcgcc agtctgatct gtgaatggga gaattctgca 1747261 tgcgcgaaaa agagagagag gtgtatgttg tcatttcgtt cattcttgtt tgcagccgca 1747321 actgttatgt ttgaactggg attcctgttc agccaattta ttttgcgatt tttgttttaa 1747381 tagtaaatga gccattttct aaaacaggag gttttttatg cttggaaaaa tcaaagcagc 1747441 cattgataat agtccaggga agccggccag aattttagtt agtgaaaaag cgtttcagca 1747501 attagaggaa gaaatgcgct ttgtttacgt ttccaaaccg aaaacgataa tggggattcc 1747561 tgtggaagtt tcagatcagg cagaaagctt caagctggaa ttttagtttt cccagactgc 1747621 taaaaggctc attttgtgtt aattatgcaa aatggtcagg ttgatttctt taaaagcatg 1747681 atgaaatgtt catcatgctt ttttattgag aaaaaagacg aacataaaaa ataggtatac 1747741 gggaaaaata atcctattag agagagggga actgacagat ggataacatg atatcaacac 1747801 ttactgactg gaatgtgtgg tttcaagcgt tagtagtatt tctcgttcca tatgtaatct 1747861 ataaagtgtt tacttggatt catgtataag aaggtgcaat gatgaggtgg cggaacaatc 1747921 agtacaaaac acagaagcag cataaatcag attattcgac agctgaaaag caggatcagg 1747981 atgtgttaac cggtaacatc ggatacgact tagaacatgt aaaaagaaaa ataggacata 1748041 acggggacgt tcatttccgt gagcttgaaa tcactcaatt acatgtgaaa gcggcattga 1748101 tctttgttga aggactgtct gatcaggact tgattaataa aggactatca gtgttagtca 1748161 tgaatcaacc taatcaggta agcgatgaaa tttctcaatc cggcaaaggt attttaactt 1748221 cgaaacagat aaaaaatcaa atcgtatcaa tcggtgatgt catagattca gagaaaatca 1748281 gtgatatcgt gttgaatgtt ttcatgggtt cgacagcgct tctcatcgat ggaataccgc 1748341 aggcctttct tctgggaact gtaaaaaaac aaaatcgaag tatcgaggag ccgctttcag 1748401 aagcgcttgt cagagggccg cgcacaggct ttacagaaga gttgagtacg aatacagctc 1748461 ttttgagaca gcaaggaaaa aatgatcaat taacattgca gagatttgaa gtaggaacac 1748521 gattaaaaaa ggatttaatt atcgcttata tgaatgacat tgcagatcca aaagtagtcg 1748581 aggaagtaag aaaaagagtg agagggattg agatcgatca tttgccggag tcaggctacg 1748641 ttgaacagtt aattgaggat aattatttga gcccgttccc gcaagtacag agtacagaac 1748701 gtcctgatcg cgtcataagc ggattaatgg aaggaagagt agctattctg cttgacggca 1748761 ctccgtttgc tttgattgtt ccagtcactt tcagcatgat gcttcaatcg cctgaagatt 1748821 attatgaacg gtggttcccg agctcgctca tcagattgct gaggttcatc gcagcaatga 1748881 taacgttatt cgcacccgct ttatatatat catttatttc ttttcatcct gggttaattc 1748941 cgaccaagct ggcgatttca atttccggga cgcgccaagg tgttccgttc ccatctctga 1749001 ttgaagcctt atttatggaa gtcgcgattg aaattttaag agaggcgggg cttcgtttgc 1749061 caaaaccaat tggacccgca ataggcatag ttggcggatt aatcatcggg gaagcagctg 1749121 tgcaggcggg gattgtcagt ccaatcatgg tcattgttgt tgcgctcaca gcaatttctt 1749181 catttgccat cccgcattat agcacaggta tagcacttcg gatgcttcgg tttggcgcga 1749241 tgttttgtgc ggcggtgttt ggattgtttg gagtcattat gtattatctg ctgctaagca 1749301 gccatgtcgt aaagctaaag agctttggtg tgccatacgc aagtccggca gtgccctatc 1749361 acttaaaaga ttggaaagac tttgttatca gaatgcctct tttagtcatg aagcgccggc 1749421 ctaaaatgat gaatacagat aatacaaaac gggtgaagtg atgaactcga caggatggtg 1749481 ataaagtctc atgttcagcc caaccagtaa aatcacaacc gctcaggcaa cgattatcat 1749541 cattaattat atgcttgctg ccggagttct tacgctccct cggacagtaa cagaacaaac 1749601 acaatctcct gatggatgga tttcagtttt attaggcggg gtcctagcgg taatagccgg 1749661 gatgattata gctaaattaa gccagcagta tcctaaggag accttttatg aatactcccg 1749721 acatattgta ggaaaatggc tcgggcatct gatcagtatt gtttttatta cttattttct 1749781 ggcactcggt gcatttgaag tcagagtcat gtccgaaatc gtggattttt ttctcctcga 1749841 agggacacct tcttgggcca tcattatgac agttctttgg attgggcttt attcaattac 1749901 acaaggccta gatccgattg cacggctttt tgaaatgatt tttccgatta cggtcatcat 1749961 ctttttaacg atagccctca tgagtttagg catatttgag atcaacaatt tgcgccctgt 1750021 attaggtgat ggaatcatgc cggttcttag aggtgtaaag acaacgaacc tttcatttac 1750081 atgttcagaa attatgttca ttttagtagc atttatgaaa aagccgaaaa atgcggtgaa 1750141 agcagttgtg atcgggacag gcgttgtgac cagtttttat atgattacga tgattatggt 1750201 catcggtgca ctatcagttg agggagttgt gacgagaaca tggccggggc ttgacctgat 1750261 gagaagtttt gaaatacctg gtttaatatt tgaacggttt gaatcatttc tgcttgtgat 1750321 ttggattatg cagctttttg ccacgtttat tatcactttt tatgcagctt ccctgggagt 1750381 ctcacaagtt tttaaaaaga aacccctttc atgtatgttt gggctgcttc ctgttatata 1750441 tatcctctct tgcatgccga aaaatgaaaa tgacgtcttt atattgggcg atacggtcag 1750501 tcatatcgct ttgtatatat ttggcgcttt gccgattttg ctgttagtca tttcgaaatg 1750561 gaggaaaaga ggtgaaaagt aaactaaaac gtcaattgcc tgctatggtc atagtatgtc 1750621 tgctgatgat ttgcgtaaca ggatgctgga gcagtcggga aatagaagat ctgggtctca 1750681 cattcgctat cgcaattgat aaaggaaaag aaacgaacac tgaaaaagag ttaaaagaag 1750741 agggcgggag ctatccgaaa aaagacaaca ttacgctgac ctatcaattt gttaatgaaa 1750801 aagcggcagg cgcgggcaca agcgggggag gcggtagcgg acaaggagcg caaaaagcgt 1750861 acattaatat aagtgaaaca ggggattcat tacagcagat cggaagtgag gttgcattaa 1750921 gacgggaccg agaagtgttt agcccgcatt taaaagttgt tgtcatgagt gaagatgtgc 1750981 tgcacacatt tcctatcgac gaaatgctgg atcaattttt tcgtgataat gaaatcaggc 1751041 tgagctgtct tgttttatct gctaaagggg aagcaagaga cgctctccag ctgaaagaga 1751101 acggagaaat tccggcattt cggctgattg gattaggtga aaatgaacat aaagtttcca 1751161 gaattcttcc ccctatgaca ctcgcgaaac taattggaaa actgcattct ggcagcagct 1751221 ttttactgca aaatgtggtt gcggcgaatg gagcggtcaa gtattccgga gcagctgtaa 1751281 tcaacggaaa atcgaaaaaa atgataggca ccttaaatga atatgaaact gaggggatta 1751341 catggattag aggagaaggg aaaggcggag ttgtcaaaag tcatgataaa aagagccaac 1751401 agacgttagc gtacgatatc aataaaatca aaagcagaat tcagccaatc gtaaaaggga 1751461 aagatatttc attccatgtc gatattgaat cagaaggcga tttggttgaa aactggaaca 1751521 caaaagaggc gttggacacc cagtttatag atcgtctcga aacgactatt gaaaacgagg 1751581 taaagaaaat agttggtcag gtattaaaaa aaattcagca tgattataaa gcagatgttg 1751641 cgggttttga tgaatctttt agacttacat atcctcactt atggaaaagg gtgaaaaata 1751701 actgggatga caccttcagt aaagccgaca tcacatacag tgtgaacgtc acaattactc 1751761 atttcggcac ggttaaaact cagtaatgaa tcccaaggaa gagaaggaaa cctctcttct 1751821 cttttttatg catttattag gataaagata ctttttttgg agagatatac acttttcaaa 1751881 tcgaccaata tgctaatata ggaattgctt gaaatagaag ggagaagggg ctgtgaggca 1751941 gaaaccgatt tatgtagaaa tcgaaatgaa atctgatctg gatacactct gggaatatac 1752001 acaaaaccca tcactgcata aggaatggga tctccggttt tcaaatatta cgtatttgaa 1752061 tagtcagcca tgcgaaaaac agaagtttct ttacgaaaca agggtaggct ttggattaaa 1752121 ggtgtcaggt acaggagaaa ccgtcggtgt tttcaacaaa tgttcatctg aaaggtcttc 1752181 ttcactggct tttggctctg atcatccatt atctctgatt cggcatggaa gcggctactg 1752241 gaagtatata cagagagaaa atgggaaaat gacgttttta acacagtacc aatacaaaac 1752301 agcctacgga ctgctgggaa gatggattga tcgtttatta tttcggccgc tgcttggctg 1752361 ggcgactgcc tggagctttg atgcattaag gctttgggta gagcaaaata aacatccgaa 1752421 gcgcttcatt cgatctgcta tcatctatgt gttcatgtgt ctgtttttca gcctgttttg 1752481 gttctatcaa ggctttgcag gtgttaagac aagcatattg acaggaacag cggagatagg 1752541 cttagctatt ttgtggctgc ttcctttaaa aagaaaatgg atcattcatg gtgtccaggc 1752601 ttgtattttt gctgggtttg cttgtctagg ttccgaaata ttcatgtggg ttctattgag 1752661 tgtgttttcc gctgcaagcg gcgctcttag cctgcagctc cccagtgcca ggcgcacaaa 1752721 acgaaagaga aagaagtgac attgtgagtt cgatttatga aaaatcaatt attaactatc 1752781 atttgctgca tcccaagctg cagaaacggt accaattaga cgggtctcat acattcagcg 1752841 ggacgggaac gatgtcagaa ataagcggag gctcttttct ggttagaatg ctgttaaagc 1752901 tgggtgtttt tttcagatgc ttcttttcag aaagaggcaa agacattcca tttacaatac 1752961 aaaatagaac ttgtcttttg aaatcgcaac atacaggaat agaatggaat cgtacatttt 1753021 tctttaaagg caaaaaacgt ttctttgatg cgttaatgat atatgacgag aaagaaaata 1753081 gaatacttga tttcttcggc aaacctcatc tgctgctgtc tgttttgacg ttcgaggcat 1753141 ctcttgacgg ctctcttacg atcacatcgg gaaagcaatg gctattgata tgcggaaaaa 1753201 gaatcccgct gccgaaatgg ctgaccggta catccgaagt ttgcgaaacg tttgatgaaa 1753261 aaaagaattg tttcaccatt gaagtgcatg tgcaaaatac aattcttggc actcttttct 1753321 tttataaggg aacgtttcag gaggaagaga gagaatcatg aaacgaaatg gcatagtcag 1753381 tgcgctttgt tttattggat ttcttgcagc agaagcaccg gatatttcag tggcagaggc 1753441 actcgttttg ttatccattc tatttttcgt gccgggaatt tttccttttg tttttcgtca 1753501 atctccggtt cgtgctgctc agtttatgga aaacgggcta atccagtgct atcctgtagc 1753561 cgcattcttt gcggtgctgg ctctagtgac ggaggttggg ggtttcgcac ttatctggtg 1753621 gatgtacaca gtttttaatg cattgtatgc gatcctccgc ctttgggaaa caaagataca 1753681 tagaatcgaa gagacatcag ttttgttcgg tcttatttat ttggcgggag gaggattttg 1753741 gttttttgct tatgctgccc atttgcagat catgcaattt ggccctctca tcattttgct 1753801 gactgctgtc cactttcact attctgcttt tctgatcccg atcttcaacg gtttactcgg 1753861 cagaaccatt agaaaacatc ggatgttgta cagttggata acatgggtga ttttgctttc 1753921 gccccttctt atcgcactgg gcatcacata ttcaaaaaca cttgatgtca ttgcggttag 1753981 catttatatg gcggcgattt atcttcatgc atttttggtg ttcacggcag cttttcgcac 1754041 caagacgggg acatttctta ttcggctttc ttccgctgtt ttaatgataa cgattgcttt 1754101 ctcgatgatt tattcatttg gtgtctttcg gcaagaagtt acattgacca tcaatcagat 1754161 gatttggatt cacggttttg tcaacgcgtt tggtgttatc ttgcccgctc tcatagggtg 1754221 gagaatagag gatgcgaaac cttttgatgc agacagtgta aagacattca gccgtatcta 1754281 cggaaaaaga aagattggag aagaattttt agctaacatt caagctgaaa ataacgctcg 1754341 gtacagcgga cttgtggatg atatgggcag cctgcgttca aaagattttt caccagaaaa 1754401 actggcgccg ctcattcttt cgttttatga acaaaccatc gaatacaata ttaaagcaaa 1754461 agtaacatgg agcacgtggt ttcggccgct tgcaattatt tacgaatggt tcagcagaag 1754521 aatcggccaa atacatcttt cgacgaaccc tgactggtat aggatgtaca gcaagataaa 1754581 aggtgttcat tcgaaaaaag acggaaggga aagagtacgt gcctggatta gaacaaatga 1754641 aaaaaacgaa accattttta ccgctcttta ttcagtgtat cgttcaaatg gagaggggta 1754701 tatgaatatt tctttaccgc ttccattcag cagcatgaca ggtattttaa aaccatatca 1754761 tcatcaggag aagctggttt taacaagcag gcggagaaaa agcagagcgg gggatgaggg 1754821 gatttatctg caaacaagag cgggaacttg tccgcttcct ttatctgaaa cctttctgat 1754881 agaagctgta catgacaaca aattaaccgc tgttcatcat atgtggctgt ttggaataaa 1754941 atttctaact gttcattaca gcattacaca tattaaccag cctattgaaa gaacctaaca 1755001 caaagaagaa gcttcgtctg ccagttgtaa tgagatgaac tgttttaaaa ttctgcaccg 1755061 catcaagaca ggaaaggaag ggtttatggt gttttatatc agtttatttc tgattctttg 1755121 gctggctgct gggtttgcag tgggaatgaa acaagtgtat gtcgatcagc tgtttgataa 1755181 agctgtgatc gaaagactgg aaaaagaagc gaatgatcat ggacatgctg accggatgat 1755241 caaacagcgc gtcctttata ttgcagcagt gacagtaagc gggtttattt ctgtttatta 1755301 tgaaatgaaa acaatcccgc aaaggcgaaa cataagaaaa attgaaaaaa acatcatgaa 1755361 attaaatcaa gcaaaaaaac gaagaatgaa gagaaaataa aaagtgcaca ggccaaaggg 1755421 caggtgcatt tttgttttgt atggaaaatg ggggaggtgg tgccagctta cttttcataa 1755481 attcaaaaat gagaagaaca gcgcccgggc taatggtata taatattgtg aatttaacaa 1755541 aaatttaaca aggaggacga gagaattcgt gctaaagcct caaagagacc tacattctgt 1755601 tgatttggac ttagaggcgg agtagatgaa accggccaaa gtatccctgc tccgccgttt 1755661 gctccattcc ttgaagcatg ttgattgtaa catagccaaa cgttttccat caactattaa 1755721 aattgtaaaa ttattgatga tttttatggt gtttactccg atttcttcaa tttatgctga 1755781 agatgtatat cagaattttg aggaattaaa aaacaatgaa gatccttctg attatggcgt 1755841 tgttacgaaa gaaaccggaa gccctgttct tgttttagct attcacggag gaggtattga 1755901 aggcgggaca agtgaagtag cgagagagct cagcaaagag tactcgatgt atttatttga 1755961 aggcttaaaa tcggcaggaa actcagtcct gcacattacg agcacacact ttgatgaacc 1756021 tcgggccctt aaaatgacgg gaaatcatga atatgtcatt tcattacacg ggtacgcaga 1756081 agaagatcag cagatcgaag tcggcggtac agatcgcgta agagcggcag atttagttga 1756141 gaaattgcag catgccggtt ttcctgctgt attgctcaat atggaccatc cgcatgcggg 1756201 cgttagtccg aataacattg caaataaatc aaaaacaggt ttaagtattc agatagaaat 1756261 gagcacaggg tttcgaaagt ctttgttcgg catcttttct ttaaaaagca gagctgttac 1756321 tcaaaatgag aggttttatg agtttacaga agtgatgttc cgttttctca aaaatagcta 1756381 ctgaaaaata ggaggcgata agacagcctc ctattcctta tgcttctctt tcgtttcggg 1756441 aaacagctcg tccgcggctt ccgtttgata ctgcaacgtg ttatctctcg ctgacagttc 1756501 atttcggaaa ttttcatcaa gcacattttt cagtaaatac cgatgaaaaa agtattcaaa 1756561 aacagtaaga caggcagcgg aaaggagagc cgctccaaat ggtgagaaat cgtttcttgt 1756621 ttgggttaaa acaaataccc aaagaataac gaatgaaagg ccaaagtcag ccaatgaagc 1756681 tgtaatattg tttgttctgg gtaagacgag catgtcacca gaaagatagg aaacaaaacc 1756741 taagaaaagt gcaataaaca tcacacttaa aaaggatgcg tgatagactc tgtccaaaat 1756801 cacatataaa agggcgagag tgaaagcaat ctttgaagca agcgcaatga tatgtttcat 1756861 ttgaccacct aaattgttat tttttgaaga aaattcttgg gcgtaaacaa atgataaata 1756921 atgcaattca aaaccattca taatggtcat gttactattt taaacagtcc gtttttgttt 1756981 acactggtat ttttttcagc tgtatgaaac tttcttatga aaaaagtcgt atatgtggat 1757041 gatcagcttt caagggggga atgatttgtg gagataaaag gaatcaatca cttgctattt 1757101 tcagtttcgc atttggatac atcgattgat ttttatcaaa aagtgtttgg tgcaaagctt 1757161 ttggtaaagg gaagaacaac tgcatatttt gatatgaacg gcatctggct agcgcttaat 1757221 gaagaaccag acatcccgag aaatgacatt aagctttctt atacccatat tgcttttaca 1757281 attgaagatc atgaatttga ggagatgtca gctaaattaa aaagacttca tgtcaatatt 1757341 ctgcctggca gagaacgaga tgaacgcgat cgaaaatcaa tttattttac cgaccctgac 1757401 ggccacaaat ttgaatttca taccggaacc cttcaagaca ggcttcgata ttacaaacaa 1757461 gaaaaaacgc atatgcactt ttatgatgaa acggcctttt gatagcacaa ccatatttca 1757521 tataaggtta aatttaaaga agggtgttgg tggagacttt atgtttgggg aaggtttcta 1757581 cccgacttgt tcaacgatgc catatctttt gaactgcaca agtgattggg tgaaggtgaa 1757641 attgaaatac acattacatt acattttata tgaagaaagc gagctgtttt atcaaatgtt 1757701 gaactaatta aactatgtac taaattttca gtatatttca attgctttgc cccttaataa 1757761 atataaaacc gcatccttcc acgacctaaa aaatgaaacg tttttaagaa gatggcgtct 1757821 aatattctaa atgttcatat tttgataaaa gtttcctaaa ggaaagaaaa tttcttgact 1757881 tcaacaatct tttggtggat aattatggtg taaacatgat gttctttttc ctcctattcg 1757941 ggctcgcacc caaaagtcag ggcgagcctg ctttttttga acaacaaacc ccctctccgt 1758001 aaaggaagag ggggttattt tatgcatctg atagatcaat agattaatgg acggttctga 1758061 acacgccaat cactttccct agaatgctga cattctgcaa aatgataggt tccatcgttg 1758121 ggttctcagg ctgcaagcga atgtgggtat cctctttata gaatcgtttt acagttgctt 1758181 catcatcttc tgtcatcgca actacaattt ccccattgtt cgctgtgttt tgctgtttaa 1758241 cgatgacata gtccttatcg agaataccag catctatcat actgtctccc ataatctcca 1758301 gcataaatac atgctcgtct ggaggaacca tgcggtcagg gagcggaaaa tattcttcaa 1758361 tattttctac tgctgtaata ggagatcccg ccgtgacttt cccgatgacc ggtacattaa 1758421 cgacctggct ttgcggaatg tctacttctt catcaagaat ttctattgct cttggttttg 1758481 tcggatctcg tctgatcagc ccttttgttt ccaaacgggc caaatggccg tggacagtag 1758541 aactggacgc aagcccgaca gcctctccga tctctctcac ggaaggcgga tatccttttg 1758601 atttaacctc tgctttaata aaacggagga tatcaagttg cctttttgat agcttcgtca 1758661 tttttcgcac ctcaaaacgt cgattttaag aagattatag catgattttc cttacagtac 1758721 aaacataggt tcgaaaaaac aattgacaga aacgtttgtt cgtatatact gaaattataa 1758781 aaatgcgaac aaacattcct gttggaggtt atgatcatga gtaaagaatc tattattttt 1758841 gtcggtctgt ttacagtgat tttgagcgcg gttatcctta tgctgtcata tacaagcagc 1758901 ggccaagagc ttaatcagta tgttaaaata gaagtccagc aaggcgacac actctggtca 1758961 attgctgatc aggtagccga tacaaaaaag ataaacaaaa atgattttat tgaatgggta 1759021 gctgataaaa atcaacttca aacctctgat atccagccgg gtgatgagtt agtgatccca 1759081 ttgaaaaaga agcatcagga tgcatatgaa ttagcaactg taagatagag aggaaagaga 1759141 gataaaatga aagcactcat ttatgcccgt gtaagcacaa ataaagaaca gcaggaaacg 1759201 tcattaaagc ggcaggagga ggagcttacg gccattgcag cggagaacgg catggaagtg 1759261 gtcaaagtga tttcagaaaa agccagcgga tatgaaatgg atcgggatgg tgtatttgag 1759321 ctgctcgatg agattaagaa cgctgatatt gatgtcattt tggttcagga tgagacaagg 1759381 ctcggacggg gaaacgcaaa aatcgcactg cttcattgta tttatagaga aggtgtgaaa 1759441 gtctatacaa cggctcatag aggtgaactg gagttatcgg aggctgactc aatggtcttg 1759501 gaaatcgtca gcattgtgga agagtatcag cgaaagattc acaacatgaa aatcagacgg 1759561 ggaatgaaac gtgcagtaaa aaacggtttt aaaccgcaaa aaaacttaaa aaaccaacat 1759621 gggaacagtg gaaaagaaaa aatagaggtg ccaatctcag agatcgtccg cctgagagcg 1759681 aataaactga cgtttgctga aatcgcggct accctaagag ggtttggcta tgatgtctct 1759741 aaagcaaccg ttcaccggcg ttttcaggaa tacatagaga atgaagagac tgcagagtga 1759801 atcagttgta aaactttttt tgatctagta ctatatagac aaaatgcaat aaaggagttt 1759861 aacatgattt caaacgcgaa aattgccaga attaatgaac ttgctgccaa agctaaagct 1759921 ggcgttatta cagaagaaga aaaagccgaa cagcaaaagc tccgtcaaga gtacttgaaa 1759981 ggttttcgtt cttctatgaa gaacacgtta aaaagtgtga aaatcattga cccagaaggc 1760041 aatgatgtta caccagaaaa gctaaaaaga gaacaaagaa ataacaaact tcactaatat 1760101 aagaggaata cggcaatatc gtattcctct tttgcatata ctataatcaa aactcttatg 1760161 tgacaaaatt caacaagttt ctctcaaatt taagctgaaa cagttgagaa aaagtcgtca 1760221 gacatttatg atgtaagggt acaacacata aggaagggga tttttatgga tacaattgaa 1760281 aagaaatcag ttgctaccat tcgcacactg tcaatagacg ctattgaaaa agcaaattct 1760341 ggtcacccag ggatgccgat gggagccgct ccaatggcat acacgctgtg gacaaaattt 1760401 atgaacgtaa gtccggcaaa ccctggctgg tttaaccgtg accgttttgt tttatctgct 1760461 ggacacgggt cagcactatt atacagcatg cttcatttaa gcgggtttga tcttagtatt 1760521 gaagatctta agggattccg ccagtggggc agcaaaacac caggacatcc ggaattcgga 1760581 catactgccg gtgttgatgc tacaacaggt ccgcttggcc aaggaattgc catggcagtc 1760641 ggtatggcaa ttgctgaacg ccatttagcg gaaacataca accgcgattc atttaacgta 1760701 gtcgatcatt atacatacag tatttgcggt gatggtgatt taatggaagg tatttcttct 1760761 gaagccgctt cactcgcagg ccatcttcag cttggccgtc tgatcgtact atacgattct 1760821 aatgacatct ctcttgatgg agacctcgac cgttcattct ctgaaaacgt gaaacagcgt 1760881 tttgaagcaa tgaattggga agttctttat gttgaggatg gaaacaatat tgaagaatta 1760941 acagcggcta tcgaaaaagc acgccaaaat gaaaagaaac ctacattaat tgaagtgaaa 1761001 acgacaatcg gattcggttc acctaaccgt gccggtacat ccggtgttca cggtgcgccg 1761061 cttggtaaag aagaaagcaa attaacaaaa gaagcttacg cgtggacata tgaagaagac 1761121 ttctacgttc cgtcagaagt ttatgagcat ttcgctgtag ctgttaaaga atcaggtgag 1761181 aaaaaagaac aagaatggaa tgctcaattc gctaaatata aagaagttta tcctgaactt 1761241 gctgaacagc ttgaactggc aatcaaagga gagcttccga aggactggga tcaagaggtt 1761301 cctgtgtatg aaaaaggaag cagtttggca tcccgtgcat cttccggtga agttctcaac 1761361 ggacttgcga aaaaaattcc tttctttgtc ggaggttctg ctgacctagc gggatcgaac 1761421 aaaacgacta ttaaaaatgc cggtgatttt acagcggttg attactcagg caaaaacttc 1761481 tggtttggtg tacgtgaatt tgcgatgggt gcggccttaa acggtatggc gcttcatggc 1761541 ggtcttcgtg tattcggcgg aactttcttt gtcttctctg attacctgcg tcctgcgatt 1761601 cgccttgcag cgttaatggg ccttcctgtg acatatgtct tcacacatga cagtattgcg 1761661 gttggtgaag acggtccgac gcacgagcct gttgaacagc ttgcttcact ccgtgcgatg 1761721 cctaaccttt ctttgatccg tccagcagac ggcaatgaga cagcagcagc atggaagctt 1761781 gcagtgcaaa gcactgacca cccaacagcg ctagtgctta cacgtcaaaa ccttcctacc 1761841 atcgatcaaa catctgaaga agcattggca ggagtagaaa aaggtgcata tgtcgtttct 1761901 aaatctaaaa acgaaacacc tgacgctctt ctcatcgctt ccggatcaga ggtaggtctt 1761961 gcaattgaag cgcaggctga attggcaaaa gaaaatatcg atgtttctgt tgtcagcatg 1762021 ccttcaatgg accgttttga gaaacaatct gatgaataca aaaacgaagt ccttcctgca 1762081 gatgtgaaaa aacgtcttgc aattgaaatg ggctcatcat ttggatgggg caaatacacg 1762141 gggcttgaag gtgacgttct cggcatagac cgattcggtg catctgctcc tggtgaaacc 1762201 atcattaacg aatacggctt ctcagttccg aacgtagtga atcgagttaa ggcattaatc 1762261 aataagtaag cttttgaaag aggatgagtc aaatcatcct ctttttcttg tttatccgac 1762321 aaaaatagta ttggctgttt aacagtaata gacaattctt tcttttcttc ttttgtataa 1762381 tagagagcaa atgaaatgct gctggaaaag gggatgaaaa gatggaacgt cactactata 1762441 cgtacctgat caaagaggaa tttgccaatc actatttcgg ccgggaatcg gttatgtttg 1762501 agctgtttca agactatcat tggacaagcc ttgaaaagca gcagtatgaa atgacagaga 1762561 aacagattca atatattaca caaccaatcc cgattttaca tatgcatcag cggttaaaaa 1762621 tgaatttaaa caagacggat tacaggcagc tggattatat ttatagaata gctttgccga 1762681 aagcaaaagg ccacgcgacg tttatgatga aggagcacat gatagaaatt gtggcttcgg 1762741 gagattacga ggcagaaacg atattctttg aagtgttaag aaaagtaagc ccttgctttt 1762801 tagcaatgga tttcaattcg aagcgttacg gatggctaaa tccggtgaaa gaaagaaatt 1762861 ttgtctaaaa ccgaagaaaa agagatgtaa atgttgtata atagcttttg gtttagtaca 1762921 ctttaaacta gacaacatga aggaggaaat aaaatgactt tatgggttgg catcctagtg 1762981 ggcgttgttg cattgctcat aggtgttgca ctcgggtttt ttattgctcg taaatatatg 1763041 atgagctacc tgaaaaagaa tccgcctatt aatgaacaaa tgttacgcat gatgatgatg 1763101 caaatgggaa tgaaaccttc tcaaaagaaa atcaatcaaa tgatgaaagc catgaataat 1763161 caaacgaaat aatacgtaaa gattatgata tagagaaaca tggttataaa ataaaaaacc 1763221 cttatacggg ttttttattt tgcaatcatt catcacccgc tactgctcga aggcgctgct 1763281 tttgatattg tatgagaaga tggtcaagct cctgactgag ctctatcgta atatgagatg 1763341 tcattccgtt cgccatgaca atttgcagca gctctgctct ttttttttca atttctttta 1763401 atagatgctc tctaatcaca gggatgtatc ctttcataca ttagatcttc aaagtgaatg 1763461 tttatattat atccatattt atactaattt tcaaatgaga aggagtataa tgtctcaatg 1763521 tcaaattaaa ttatataagt tttttctgaa aatagaaatc cttcaagtga aagtgttaaa 1763581 aaaatgaaat gattttgtca taacttgaag gaatgtcaaa tcatgaaggg atgatgacat 1763641 gggagacgtg aattattttt tgacattcgg agcggggttt ttatccttta tttcgccttg 1763701 ctgcctgccg ctttacccag cttttttgtc atatattaca ggggtcagca tggacgatgt 1763761 aaaaactgaa aagctgctgc tgcagaaaag aagcttgttt catactttgt gttttttgct 1763821 tggcttttca gtcattttta ttgctttagg ctatggaaca tcttttattg gcagcctgtt 1763881 tagggattat cacgatgcga ttcggcaaat tggcgcgttg cttattattt tgttcggttt 1763941 cattacactc ggtgtgttcc ggcctgaggc tatgatgaaa gagcggagaa tccattttaa 1764001 gcataaacca agcgggtttt tagggtcggt cttaatcgga atggcatttg cagctggatg 1764061 gacaccatgt accggtccga tattagctgc tgttatcaca cttgcaggca ccaatccggg 1764121 ctcagcggtg ccatacatga tgttatatgt actcggtttt gcggtaccgt ttcttttatt 1764181 gtcttttttt atcacaaagc tgaagtggat aaggaagaac cagcttttca ttatgaaagc 1764241 tggtggcgtt ttgatgattg tgattggtgt gctgttattc tttaattgga tgagcctgat 1764301 cattattttg ctgtcagatc tttttggagg ctttactggt ttttgacggt aaattacttt 1764361 cgtactacta ctaatccttt tgtttttggt acaataagac tattatctgt ggaaatcgat 1764421 tgttggaggg gaatatgaca agagttttag ttgtagacga cgccaagttc atgagagtga 1764481 aaatcagaga gatcttggaa gaggcaaatt acataatcgc aggcgaagcg gcggacggtg 1764541 aacaagcagc tgacctgtat aaaaaactgc gcccggacct tgtgacaatg gatattacaa 1764601 tgccggtgaa aaacggcata aaagcgcttc gtgatatctt aacctttgat cctaaagcga 1764661 aggtcatcat gtgcaccgcc atgcgccagc aaagaattgt aacggaagca attgagctgg 1764721 gggcaaagga ttttattgtt aagccgtttg aggaaacaaa agtgctggaa gctgtaagcc 1764781 gcgttatggg acattaaagt catttctttt caaaatggtt ttttttattg ttttggagta 1764841 tagtatatag tatcaacact ccgagaaaca aaggaatgat aagtatgatg attatagttt 1764901 catcaattat tgctgtgtta atggctgtag ctgtgatggt ggtcagaata aagtcctctg 1764961 acaagcctgt ttcaccaaaa aaaatcattc ttccgccgat ttttatgagt acgggagcgt 1765021 taatgttttt atttccggta ttttgggtaa ctggagcaga gtttttggaa gcattcactt 1765081 taggtgtgat tttctctatt tttctaatca aaacttctaa gttcgaaatt aaaaataatg 1765141 aaatttacat gaaacgctct aaagcatttg tttttatatt agtcggtctt ttggtgatca 1765201 gaatcgtgat gaaatcgatc ttgagcacat caattgatta tggtgcactg agcggaatgt 1765261 tttggattct ggctttcggt atgattgtgc cttggagaat cgccatgtat ttatcatatc 1765321 gaaaacttca taacgagctg cagtcatcta atattcaaat gaattaaaaa acctttcctc 1765381 ttgtcaggaa aggtttttta tttgagaagg gtctgataag gttccaaatc gatttttttg 1765441 tcccgcagat gcctttttaa gaaggtatgg tctcttttag gagttgcgag aatatagcct 1765501 ttgatcataa gttgctgatc aatctttgct accttttctt ttaatgcaag ctcaccgatt 1765561 ttgcctgcga ttttagcttt tgctgcatct ctgaacagct ctggcacggg cgcagtcaat 1765621 tcatctagaa actgtttgtt ttcatcgttc cataaatgtc tgctgttttc aatatagtaa 1765681 tcctgccaat caagctctga tctgccgtcc tcttttggta aacgctttaa aaactttcga 1765741 aacatgaaaa aaccgccgat tgataataag actaccatca tgattaccca aaacagaata 1765801 aaccataaaa accatccttc cagcatcaat cattccccct tattctaacc atattgtata 1765861 cgaagagaga ttagaagaac acagtaaaaa aagaatagaa aaaagtgata gacgtctagt 1765921 caaaagagat agtagatcat attctattgt atagtgaatc tgctatttgg ccatgggaga 1765981 gtcactagag ggtatttgac gataaatgga cggaaaaaaa gtcactttca taatagggga 1766041 tgaaagtgac tttttatgtt tagctgagag gaaattgaag agaaaaagaa gagccatctt 1766101 ctgtttcttt attgacggcg actgtgagta tttgattttc gcattcgact tgaatgtttt 1766161 tgtcattaaa ataaaaagga agcatcattt gtttttcaaa agtctgtcct gacgatttga 1766221 cagttaagat gaactcgcat ccagaaaggg taactgttac ttgtgtaggc tgtaaaaaag 1766281 tcagatccgc ttctataata tactgctgac ttgtttcata taaatcaata ggcaatgttt 1766341 cgtcgtacca ggcgaagggg tcttcaaaaa attgccgaag ccattcatcc atactatcga 1766401 aatcattcgc atcgttgcgt tttgaatggt tcatggaagc attcctccac atatcaacct 1766461 tgctttacat catatgcggt ggattataaa tgggtgaacg cataaaaaaa cagacactaa 1766521 ggtctgcttt tcttacatat catggcttga gttgtgcttt tgtcttgtat ggtttcggtt 1766581 ttttactttt ttgcttccgc ttagaggctc gggttggccg ggattgtgtc ctttaggggc 1766641 gtttttatgc atatctttac ttgtattctt attggtcata aaatgagaac ctccttaaaa 1766701 gagttcggtg ttattgattg gtttttcttt ttttgttatt ttggcgttct gcttcagtca 1766761 gtacaagctg gtcgttttca atatagccgg cgcctttgcc ttggcttttt gcgtcattca 1766821 ttccgttaat gacgtgattc gcttttcttt tgaccatcat tatcacctca atcataatat 1766881 ggcttctttt attgtgttat atgagagagc gtaaacagta aaaattaccg gtacattttt 1766941 ctcataagtc gaacttattg tatttaataa aaacattgat atttacttat gtatgatttt 1767001 gttttaatat gaaattgtga gaaaattgtg atggaatgta atgttcatct gagaatgatc 1767061 tgatctgaag ggggattttg gagaatggca aacgagcaaa aaactgcagc aaaagacgtt 1767121 ttccaagcga gaaaaacgtt tactacaaat gggaaaacat atcattacta ctctttaaaa 1767181 gcgttagaag attcaggtat aggaaaggtt tcgaagcttc cttattccat caaagttctt 1767241 ttagaatcag tattgcgtca agttgacggc ttcgttatca aaaaagaaca cgtggaaaat 1767301 ttggcaaaat ggggaactgc cgaattaaag gatatcgacg ttccgttcaa accgtctcgt 1767361 gttattttac aagacttcac aggggttccg gcagtagtag atctggcttc actgcgtaaa 1767421 gcaatggcag ctgtcggcgg agatcctgat aaaatcaacc ctgaaattcc tgttgatctc 1767481 gttatcgatc actctgtaca ggtagataaa gcgggtacag aagatgcatt agcagtaaat 1767541 atggacttgg aattcgaaag aaatgcagag cgctacaaat ttttaagctg ggcaaagaaa 1767601 gcgtttaaca attatcaggc agtaccgcct gcaacaggta ttgtgcacca ggtcaacctt 1767661 gagttcttgg caagtgttgt ccatgccatt gaagaagacg gcgagcttgt aacgtatcct 1767721 gatacgcttg tcggaacaga ctcacacaca acaatgatta acggtatcgg tgttctcggc 1767781 tggggtgtcg gtggaattga agctgaagcg ggaatgcttg gacagccttc ttacttccca 1767841 gttccagagg taatcggcgc gaaacttgtc ggcaagcttc caaacggaac aacagctact 1767901 gacttggcgt taaaagtaac acaagtgctg cgtgaaaaag gcgttgtcgg taaatttgtt 1767961 gaattcttcg gaccgggaat tgctgaactg ccgcttgcag atcgcgcaac aattgcgaat 1768021 atggctccgg aatacggtgc tacatgcgga ttcttcccag tagatgaaga agcgcttaac 1768081 tacctgcgcc tgactggccg tgatcctgaa catattgatg ttgttgaagc atactgcaga 1768141 agcaatggct tgttctacac tccagatgcg gaagaccctc aatttactga tgtggttgaa 1768201 attgacctgt ctcaaattga agcaaactta tcgggtccaa agcgtcctca ggatttgatc 1768261 ccgctatctg ctatgcagga aacgtttaaa aagcaattag tcagccctgc aggtaaccaa 1768321 ggattcggtt taaatgctga ggaagaaaat aaagaaatta agtttaaact ccttaacggc 1768381 gaagaaacag ttatgaaaac gggtgcgatc gccattgctg cgattacaag ctgtacaaat 1768441 acatcaaacc catacgtgct gatcggcgcc ggactggtag cgaaaaaagc ggttgagtta 1768501 gggcttaagg tgcctaatta cgtgaaaacg tcacttgcac cgggttctaa agttgttaca 1768561 ggatatcttg tgaattcagg ccttcttcca tacatgaaag agcttggctt taacctcgtt 1768621 gggtacggct gtacaacatg tatcgggaac tcaggtccgc tttcaccgga aatcgaagaa 1768681 gcggttgcga aaaatgatct tctgattacg tctgtccttt ccggaaaccg taactttgaa 1768741 ggacgtattc acccgcttgt taaaggcaac tatcttgctt caccgccgct tgttgtggca 1768801 tatgcgctgg ctggaacggt aaacattaac ttaaaaaccg atccaatcgg tgtgggcaag 1768861 gatggtcaaa acgtatactt taatgatatt tggccgtcaa tggacgaaat caatgcactt 1768921 gttaagcaaa ctgttacgcc agagctattc cgcaaagagt atgaaacagt atttgatgac 1768981 aacaagcgct ggaacgaaat tgaaacaaca gatgaagctt tatataaatg ggataacgat 1769041 tcaacttaca tccaaaaccc accattcttt gaagagatgt ctgttgagcc aggcaaggtt 1769101 gagccattaa aaggactgcg tgttgtcggt aaattcggcg attcagtcac aactgaccat 1769161 atttctcctg cgggggcaat cggaaaagat acgcctgccg gaaagtattt gcaagaaaaa 1769221 ggtgtttcac ctcgtgactt taactcctac ggctcccgcc gtggaaacca tgaagtcatg 1769281 atgagaggaa catttgccaa cattcgcatc aaaaaccaaa tcgcaccggg tacagaaggc 1769341 ggatttacga cgtactggcc gactggtgaa gtaacatcca tctatgatgc atgcatgaaa 1769401 tacaaagaag ataaaaccgg tcttgtcgta ttagcaggaa aagactatgg tatgggatct 1769461 tcacgtgact gggctgcaaa aggaacaaac cttctcggca tcagaacggt cattgcagag 1769521 agcttcgaaa gaattcacag aagcaatctt gtattcatgg gtgtgctgcc gcttcagttt 1769581 aaacaaggtg aaaatgcgga tacactcggc ttaacgggta aagaagtcat cgaggtagat 1769641 gttgatgaaa cagttcgtcc tcgtgacctt gtgactgtaa gagcaatcaa tgaagacggc 1769701 aatgtaacaa cttttgaagc agtcgtccgc tttgatagtg aagttgaaat tgattactac 1769761 cgccatggcg gcatccttca aatggtgctt cgtgaaaaaa tgaagcagtc ctgatgaatc 1769821 aataggaaga gaaggcattt cgctttctct tctttttatg acacaatgtg ctgcggaggt 1769881 ggcatatgct gaaaaaatgg ctcgcaggga tcctgcttat catgctagtc ggttatacgg 1769941 gatggaattt atatcaaaca tacagcaaaa aagaagtcgg aattcaagag gggcaacaag 1770001 cacctgattt ttctttgaaa acgctatcag gagagaaaag ctctttacag gatgcaaaag 1770061 gcaaaaaagt gctgctcaat ttttgggcaa cttggtgtaa gccgtgccgt caggaaatgc 1770121 ctgcgatgga aaagctgcaa aaagagtacg ccgacaaact tgcggttgtt gcggtaaatt 1770181 tcacttcagc tgagaaaagt gagaaacagg tccgagcgtt tgctgatact tatgacttaa 1770241 cgttccccat tctgattgat aaaaaaggga tcaatgctga ctataacgtg atgtcatatc 1770301 caacgacata tatcttagat gaaaaaggtg ttatccaaga catacatgtt ggcaccatga 1770361 caaaaaaaga aatggaacaa aaactggatc ttgattagat tcagtttttt ttatactcaa 1770421 atatgcttac aagttttcag aattggaaaa aataaaagaa tatgcggagg tgagaagcgt 1770481 gaagaagatg agaaaacgtt cttttcatga gctcgtcatg gaaaacaaaa aagagctgat 1770541 gaccaataca gagtatttaa atcagcttga ggaaaagctt gaacagcgat ttaagcaaaa 1770601 ataaccttta atttgtattc atgtttaccc ctccttttga gaaacctatc tgttgaggag 1770661 ggataaacat gggaaacaac aagaaaaacg gtcagcctca atatgctcca agccacttgg 1770721 gtacaaagcc tgtaaaatat aaagccaata aaggggaaaa aatgcatgat acttcaggac 1770781 agcggccgat tatcatgcag acaaaaggcg agtagcgaaa attcgagttt atttctagga 1770841 ggtacatccg aatgacaaag aaccaaaatc aatatcagca gcctaatcct gatgatcgtt 1770901 ctgacaatgt ggaaaaattg caggatatgg ttcaaaatac aattgaaaat atagaagaag 1770961 cagaagcatc aatggagttt gcttcaggag aagataaaca gcgtatcaaa gaaaaaaatg 1771021 caaggcgcga acagagcatt gaagcgtttc gtaatgaaat acaggacgaa tctgcagcga 1771081 gacaaaacgg ataccgttct taaaaaacca gggaaacctg gtttttttct ttctgatttg 1771141 attatggtaa aatggggcta aattgacgtt aagggagcag agtaatcttg catgtatcaa 1771201 aaaaagaaat agaagtgcgt tatgcagaaa cagatcaaat ggggattgtc tatcacgcaa 1771261 attatcttgt gtggatggag gtcggcagaa cggccttgat taaggactta ggctttttat 1771321 atagtgatat ggaaaaaaaa ggcgttctgt ccccagtcgt tgatatcaat atttcctata 1771381 aaaagccgct tcattacgga gaaaccgcgg ttgtacatac atggatagag gactataacg 1771441 gatttaaaac cgtctatggt taccacattt ataatccggc cggtgagctt tccatcaaag 1771501 ccacctcatc tcatatttgt gtggataaag aaagctttaa gccaattcaa ttccgcaaag 1771561 cttttcctga ttggcacaca gcatatgaaa aggccaaaaa atagggaagt gaacgggata 1771621 tggcgtttgg tgtgaaacgg gaggaactta accggtggaa acaagcagtg aaaagaggag 1771681 aaatcgcatt tttaacacat tactggctgg atgaccgatt tccagaagca aagaccgtga 1771741 caaaagccgg ctgtgcagac attgataagc tggttcagtg gggagcggcg tacgggttaa 1771801 aaaaagaatg gatccataag aaaagtgaat ttccccactt tgatctgctg ggggaaacac 1771861 aaaaatatat tttggaacaa gaaaacctaa ccgatcatct tatacgattt catttgtaaa 1771921 aaaagaacgc acatgaagtg cgttcttttt tattggtatt caaaaaccgg ttcatcagcg 1771981 tcttctgaat agctgacgag aaggtcgtgg ttatcaaagt accataaatc actttcttca 1772041 ataaagaagg taatgccatc agcttctgca gtgactccag cctcttgtgg ggcatctttc 1772101 gctacaccga gagaaaaacc cttttgaacg ttgctgcagc ctccatagcg gacgaaaaag 1772161 cgaacctggt ctccgctttc caaatcgagt tcttctttat accagttcaa tgcgtcttcg 1772221 ttaattgtca tattcataac agaacacccc tttgttcttc atttgaattt tctctattat 1772281 aaacgtatta ggctattctg tgtcaaaaga gaagtttttt aagcttataa ccattttact 1772341 ttaggttctg ttttattgat aattcgttta atgttcgctc ggtgtctgta tatcacaaaa 1772401 atagtgagca gggtaacgac aatcaataaa tacgtatcat ggacaaagaa actatatata 1772461 acagtataga tccctgttaa catcgatgag agagaaacaa atttagtcaa gtataaaaag 1772521 atgaagaata ccgcaaccat cgtgataaat aacaggggtg cgtaaaatag caaaacgcct 1772581 cctgatgtcg ccacggcttt accgccttta aatttggcga agatgggaaa cacgtggcct 1772641 aaaaccgcaa agactcctgc aagaagcggg tgaatatcaa catgcatgag aaaaggcaat 1772701 gcagttgcca gtgtcccttt caaaatatct ccggctatga cgaccgaacc agcttttaca 1772761 cccaatgtac ggaatgcatt ggtagcgcct aagttgccgc ttccgtgctc ccgaatatca 1772821 attcctttgg caagcttgcc cacaattaag ccagatggaa tgctgcctat caagtaggcc 1772881 aaaataatca ataaagcaat taacatctac atttctcctt tttcaaattc ccttcttttt 1772941 attttaacat gagatgtcat gatctgatga taagtttttt tgtaaagttt gcttacaaat 1773001 caaatcaaac atgcatcata ttttgatttc tcctgttttg atcgtgtaaa ataagtgaaa 1773061 aaggagtgac acacgatgca aaacccttct aaagcggaaa ttaaagagat tcttcaaaga 1773121 agcaaacgta tagcggtagt agggctttca gaccgtccgg atagaacgtc acatatggtt 1773181 tcaaaagcaa tgcaggacgc gggttatgaa attatccctg tgaaccctac aattgatgag 1773241 gcgctaggtg tcaaagccgt ttcatcttta aaagagatag acggtccgat tgacatcgta 1773301 aatgtattcc ggcgctcaga acagcttcct ggagtggcgg aagagttttt agagacagat 1773361 gcgccagtat tttgggcaca gcaagggcta gttaatgagg aagcatacca gatgctaaaa 1773421 gaaaaaggca gaacggttat catggatctg tgcataaaag tggcacacgc tgtaacaaaa 1773481 taggtgcaga actgcaaaaa tccttgtaaa ttcaaggatt tttgcttttt aattttaaga 1773541 tattgtttgc gtattacggt gaaacagata caataaagct tgaacagctt tttttgaata 1773601 ccttgtccag ctgggtttcg gccgttcgat ttgcgaaggt ctgctgcttt atatataata 1773661 aacaaacata cgttctcata gtgtaaaaac agcactagcc gatgttttga gaagaactga 1773721 ttcgttagct ctatgttgcg attgcaaaca tattggttat aatgaggagt ccaaggcagt 1773781 actggctcga ggcgaggttt ataaaaaata tcttatatac aaatgatgtg taacactgaa 1773841 aagagaaaga caatgttagt ttttgaaagg ggtttgtacg tttggctaga aaacagcaat 1773901 ttgattacaa cgaagatgcc atacaggtgc tcgaaggcct tgaggctgtc aggaaaaggc 1773961 cgggtatgta tattggctct actgacgcgc ggggtttgca ccacttggtt tatgaaattg 1774021 tagataactc tgtcgacgag gtgcttgccg gccatggaga tcacataatc gtcaaaatac 1774081 ataaagacaa tagtatttct gtacaggata gaggccgcgg catgccgacc ggaatgcata 1774141 agctcggcaa accaacccct gaagtgattt taacggtgct tcatgccgga gggaaattcg 1774201 gccaaggcgg ctataagaca agcggcgggc tccacggagt tggtgcatca gtcgtgaatg 1774261 ctttatctga atggctgacg gttaccattg agcgggacgg ttttgtctat cagcagcgat 1774321 ttgaaaatgg aggaaaaccg gttacatctc tcgaaaagat cggcaaaaca aaaaagacgg 1774381 gaactcttac acactttaag ccagatccaa cgatgttcag cacaaccact tataattttg 1774441 aaacgctctc tgagcgctta agagagtctg cgtttttgtt aaaaggactg aaaattgagc 1774501 tgattgatga acgcaatgac cagcgtgagg tcttttatta tgaaaacggc atagaagcgt 1774561 ttgttgctta cttaaatgaa gaaaaagacg tcttgtctga agtggtctcg tttgagggtg 1774621 agcatcattc tatagaagtg gactttgcgt tccagtttaa cgatggttat tctgaaaata 1774681 ttttgtcgtt tgtcaacaat gtcagaacaa aagacggcgg gacgcatgag tcaggtgcaa 1774741 aaactgcgat gacgcgtgct tttaatgaat atgcgcgaaa agtggctttg ctgaaagaaa 1774801 aggataagaa ccttgaaggc accgatataa gggaagggct ttcagccatt atttctgtcc 1774861 gcattcctga ggagcttctt caatttgagg gacaaacaaa aggaaagctc ggtaccagtg 1774921 aagcaagatc agcggtggat gcgattgttt cagagcagct tgcttacttt ttagaggaaa 1774981 atcgggacac cgcaacgctt cttgtcaaaa aagcaatcaa ggcgagccag gcgcgcgaag 1775041 cggcacgcaa agcccgtgaa gaagcaagaa gcggcaaaaa acgaaaaaaa tcagaagcga 1775101 ctttaagcgg aaagctgacg cctgcgggtt caagaaaccc ggcaaaaaat gaattgtatc 1775161 tcgttgaggg agattcagca ggcgggtcag ccaagcaggg acgagaccgc agattccagg 1775221 cggttctgcc tttacgcggt aaagtcatta atacagaaaa agctaagctt gctgatatct 1775281 ttaaaaatga agagatcaat acgatcattc atgcgatcgg cgggggagtc ggggcagatt 1775341 tctcaatcga tgacatcaac tacgacaaaa tcatcattat gaccgatgcc gatactgacg 1775401 gcgcccatat tcaagtgctg cttcttacct ttttctatcg ctatatgaaa ccgctcattg 1775461 agcatggcaa ggtgttcatt gcgctgccac ctttatataa ggtcagtaaa ggaagcggga 1775521 aaaaggaaat cattgaatat gcatggtctg atgaagagat gggggatgtc ctgaaaaaag 1775581 tcggcaaagg ctataccatt caacgatata agggtcttgg agagatgaac gcagaccagc 1775641 tgtgggaaac gacgatgaat ccggagtccc gcacacttgt tagggtcaaa attgacgatg 1775701 cggcacgtgt agagagacgt gtgacgacgt taatgggaga caaagtagag ccgcgcagaa 1775761 agtggattga gaaaaacgtc gctttcggct tagatgaaga aagcaatatt ttagaaaatg 1775821 aaaacttatc ggtcgctgag gaggtttaat gattgtcaca gccagaatta tttcatgatt 1775881 taccattaga agaggtgatc ggcgaccgtt ttggacgcta cagtaaatat attattcaag 1775941 acagggcgct gcccgatgcg agagacggat taaagccggt acagcgcaga attctgtatg 1776001 caatgcatac agatggaaac acgtttgata aaaacttcag aaaagcggcc aaaacggtcg 1776061 gtaacgtcat cggtaactat catccgcacg gtgacagctc ggtttatgaa gcaatggtgc 1776121 ggatgagcca ggattggaaa gttcgtaatg tgttaatcga aatgcatgga aacaatggaa 1776181 gcatcgacgg agatcccccg gcagccatgc gttatacaga ggcacgatta tctccgatag 1776241 catctgagct tcttcgggat attgacaaaa acacggttga atttgtgccg aacttcgatg 1776301 atacaagcaa ggagcctgtc gtactcccgg cgatgtttcc taacctattg gtcaacggat 1776361 ctaccgggat ttcagcagga tacgcgaccg acattccccc tcatcatctg ggagaagtca 1776421 ttgatgctgt cattaagcgt attcaaatgc cttcttgctc tgttgacgaa ctcatggaag 1776481 ttattaaagg gcctgatttt ccgacaggcg gtattattca gggcgttgac gggataagaa 1776541 aagcttacga aaccggaaaa ggaaaaatca ttatccgcgg aaaggctgaa attgaaacaa 1776601 tcagaggcgg acgagaacaa attgtcatta ctgaaattcc atttgaagta aataaagcaa 1776661 accttgtaaa aaaaatggac gagttccgta ttgataaaaa ggttgaaggc atctcagagg 1776721 ttcgtgatga aacggatcga acagggctga gagtggtcat tgaactgaaa aaagaagctg 1776781 atgccaaagg cattttgaat ttcttatata aaaatactga tttgcagatc acatataact 1776841 tcaatatggt ggctatccat aaccgccgtc cgatgctgat gagcctgccg tctattttgg 1776901 atgcatatat cggacaccaa aaggaagttg tcacaaaccg gtccgtttac gagcttcaaa 1776961 aagcaaaaga cagacatcat atcgtagaag ggctcatgaa agctttgtct attttggatg 1777021 aagtgattgc aacaatccgt tcttctagcg ataaacgtga cgctaaaaac aatttgatcg 1777081 cgaaatatga atttacagag cctcaggctg aagccatcgt gtcattgcag ctatatcgtt 1777141 taaccaatac cgatatcaca gcgcttaagg aagaggcaga agagctcggt aaaaaaattg 1777201 aagagctcga atctattctg agcaatgata aaaaactgct aaaagtgatt acaaacagct 1777261 taaaagcact gaaaaagaaa tatgcagata cgagacgctc cgtgattgaa gaaaaaattg 1777321 aagaaattaa aatcaatctc gaagtcatgg ttgcatctga ggatgtatat gtaaccgtta 1777381 cgaaggatgg ttacctaaaa cggacgagcc agcgctcatt tgccgcttcc aacggtcagg 1777441 acttcggaat gaaagatacg gacaggatgc tgcatcagtt tgaaatgaat acgacagacg 1777501 tgctgctgct ctttacgaac aaaggaagct acatctattg tcctgttcac cagctgcctg 1777561 atatcagatg gaaggacatg ggccagcatt tttcaaatct aatcactatt gaccgtgatg 1777621 aaacgattgt aaaggctata ccgataaaag aatttgatcc gtcggcatat cttctattct 1777681 ttacgaaaaa cggtatggtg aaaaagacag agctcactca ttataaagca cagcgttatt 1777741 ctaaggcact tgtagcctta aatctgaagg gtgaagatga actgattgat gtacatgtaa 1777801 caaatgggga aagccagatc tttatggcca ctcacttagg gtatggtcta tggtttggag 1777861 aagacgaagt gaatgtagtt ggcgcgcgtg cggcaggtgt caaagggatt aacttaaaag 1777921 aggatgactt tgttgtctcc ggtgagattc ttcagcaatc tgattcaatt gtcttgttca 1777981 cacagcgggg agcggttaaa cgcatgagtc tttctgagtt cgagaagaca tcccgtgcaa 1778041 aacgcggtgt cgtaatgcta agggaactga aaaagaatcc tcaccgtgtt gtagcactgt 1778101 tcgcttgcgg tcttgaacag cgactaatgg cagaaacaga aaaaggcgac agaaaagaac 1778161 tgcagacaaa agagttgcgg acaaacgaca gatacagcaa tggctctttc ttttttgatg 1778221 aagaggaatc aggcaaggtt acagctgttt ggcgccttca tacagaacaa taataaaaaa 1778281 cccgctcata ctatatgagc gggtttcgtt tgttttttat cagctttcat ggttggtgaa 1778341 tagatctgtt acagcatgaa tgacttcaat cccctgccat acaaataaat tcagcgctgt 1778401 gaaagaaaat aagcctaaaa tcaccattct taagataaac aacatgttta acagcctcct 1778461 catattttcg ttacataatc gggtgatgtt gaacatgaag tttgccgaaa taagacgatt 1778521 gataaaattt ggccagtata aagctttttt tccgctgacg tctgcgggag tatcccgtac 1778581 ttttgctttc agcggtcagc agcagaacag ccattgccca taaagcggtc agcgtaaatg 1778641 cccctgtgat ggatttcttc tcatcatcag cattttggcc ggctttcatc tcatgcattt 1778701 cctgctggtc ggctacggct ttataatgat ggccgatatc aaaggcgtgg ggaattgaga 1778761 acaaatgaaa actggcaatc gccaagaata agatggatgc tttcaatatc gttacttttt 1778821 tcaaatgatc tccccctcct ttaatattac tgaatatttt tataataata ccccaatcca 1778881 tcctaaaagt aaacctgatt tattaaattt aaaaataaat ttaactttgt taagtatata 1778941 tctttttgct tatttttgaa agagaaaact tcttttatta gcgtatgtat acccggttta 1779001 tggtgtgaat aaaaacatat tttaaatgat atgttgttta ggatttatta ctttatttat 1779061 gtgtaaatca aagagaaagg caagagaatg ggaagaaatg attacattgt taatagggta 1779121 ctcttttttt aaagccagtt tgcaaggaat gtttttattc gtaggaaaat aatagagaag 1779181 gggtcgacag agtaacatct ggctatgaca atattcttct cgaaaaaact tcctaattcg 1779241 tcatattgtg atataataaa actcgttatg ttaaaaaatc taacatcaaa atcgaattcg 1779301 tattgaattg atgaaaacgg gaggtaaata tggagtcttt tttcaatagt ttgattaata 1779361 ttccaagtga tttcatctgg aaatacctat tttatatttt aatagggctt ggattatttt 1779421 ttaccatacg ttttggtttt atccaattcc gttattttat tgaaatgttc agaatagtag 1779481 gggagaagcc ggaaggaaat aaaggtgttt catctatgca ggcattcttt atttcggccg 1779541 catcccgagt cggcacaggg aatttgactg gtgtagcctt agcaattgcg acaggcggac 1779601 caggcgctgt attttggatg tgggtagtgg ctgcagtagg catggcttca agctttgtcg 1779661 aaagtacatt agcacagctt tataaggtaa gagacgggga ggatttccgc ggagggccgg 1779721 cctactatat tcaaaagggt cttggtgcca gatggcttgg catcgttttt gcaatcttaa 1779781 ttaccgtctc attcggcttg atttttaacg ctgttcaaac aaatacaatt gctggagcat 1779841 tggatggcgc attccatgta aataaaatag ttgtagccat agttctggcg gttttaactg 1779901 cgtttatcat tttcggcggt ttaaaacgtg ttgtcgctgt ttcacagcta attgtgccgg 1779961 ttatggcagg catttatatt cttatcgctt tatttgttgt catcacgaat attacggctt 1780021 tccctggcgt tatcgctaca attgttaaaa atgctttagg ttttgaacaa gtcgtcggcg 1780081 gcggaatagg cggcatcatc gttatcggtg cgcaacgcgg acttttttca aacgaagcag 1780141 gaatggggag cgcaccaaac gcggctgcga cggctcatgt atcccatccg gcaaagcaag 1780201 gctttattca aacattaggc gtatttttcg atacatttat catatgtacg tccacagcat 1780261 ttattatttt gctgtacagt gtaacgccaa aaggcgacgg catccaagtc acacaggctg 1780321 ctcttaacca tcacattgga ggctgggcgc cgactttcat cgcagtcgca atgttcttgt 1780381 ttgcattcag ttcagttgtc ggcaactatt attatggcga gacaaacatt gaatttatta 1780441 aaacaagcaa aacatggctg aacatttacc gtatcgctgt tattgctatg gttgtgtatg 1780501 gatctttatc aggcttccaa atcgtttggg atatggcgga cctctttatg ggtatcatgg 1780561 cgctgatcaa cttaattgtg attgcgctgc tgtcaaacgt tgcttacaaa gtgtataaag 1780621 attacgcgaa acagcgtaag caaggacttg atcctgtgtt taaagcgaaa aacatcccag 1780681 ggctgaaaaa cgctgaaaca tgggaagatg agaaacaaga agcataatat aaatataaaa 1780741 caaagctgca ttcaatagtt gaatgcagct ttttcattat tggaaataaa tttaattttt 1780801 cgactcgaat gaaaaatgac gtgtaaagtc ccaattcagt ccagttttct ttgttctata 1780861 tgtgtcatgt gtgtcttatt cattggaggt agagcaaatt gacaggcttt taaacctccc 1780921 caaaacaaga aattaggttg atagacaatc atgagaaaga tttttacaat gagttcgtgc 1780981 tcataagaag tgtagagcca aaatgatgcg aaggaggaaa agatcagata tgaaacggtc 1781041 aatctctatt tttattacgt gtttattgat tacgttattg acaatgggcg gcatgatagc 1781101 ttcgccggca tcagcagcag ggacaaaaac gccagtagcc aagaatggcc agcttagcat 1781161 aaaaggtaca cagctcgtta accgagacgg taaagcggta cagctgaagg ggatcagttc 1781221 acacggattg caatggtatg gagaatatgt caataaagac agcttaaaat ggctgagaga 1781281 tgattggggt atcaccgttt tccgtgcagc gatgtatacg gcagatggcg gttatattga 1781341 caacccgtcc gtgaaaaata aagtaaaaga agcggttgaa gcggcaaaag agcttgggat 1781401 atatgtcatc attgactggc atatcttaaa tgacggtaat ccaaaccaaa ataaagagaa 1781461 ggcaaaagaa ttcttcaagg aaatgtcaag cctttacgga aacacgccaa acgtcattta 1781521 tgaaattgca aacgaaccaa acggtgatgt gaactggaag cgtgatatta aaccatatgc 1781581 ggaagaagtg atttcagtta tccgcaaaaa tgatccagac aacatcatca ttgtcggaac 1781641 cggtacatgg agccaggatg tgaatgatgc tgccgatgac cagctaaaag atgcaaacgt 1781701 tatgtacgca cttcattttt atgccggcac acacggccaa tttttacggg ataaagcaaa 1781761 ctatgcactc agcaaaggag cacctatttt tgtgacagag tggggaacaa gcgacgcgtc 1781821 tggcaatggc ggtgtattcc ttgatcaatc gagggaatgg ctgaaatatc tcgacagcaa 1781881 gaccattagc tgggtgaact ggaatctttc tgataagcag gaatcatcct cagctttaaa 1781941 gccgggggca tctaaaacag gcggctggcg gttgtcagat ttatctgctt caggaacatt 1782001 cgttagagaa aacattctcg gcaccaaaga ttcgacgaag gacattcctg aaacgccatc 1782061 aaaagataaa cccacacagg aaaatggtat ttctgtacag tacagagcag gggatgggag 1782121 tatgaacagc aaccaaatcc gtccgcagct tcaaataaaa aataacggca ataccacggt 1782181 tgatttaaaa gatgtcactg cccgttactg gtataaagcg aaaaacaaag gccaaaactt 1782241 tgactgtgac tacgcgcaga ttggatgcgg caatgtgaca cacaagtttg tgacgttgca 1782301 taaaccaaag caaggtgcag atacctatct ggaacttgga tttaaaaacg gaacgttggc 1782361 accgggagca agcacaggga atattcagct ccgtcttcac aatgatgact ggagcaatta 1782421 tgcacaaagc ggcgattatt cctttttcaa atcaaatacg tttaaaacaa cgaaaaaaat 1782481 cacattatat gatcaaggaa aactgatttg gggaacagaa ccaaattagt taagcttttt 1782541 tttggcggac atcagtaacg atgtccgttt ttatcatcta ataggaggtt tgcgttgtgg 1782601 atgaaatact gaaacagtat atggtgctgt ataaaaaaat gagtaatatg ataaatggtc 1782661 ccgactatcc aggtaaggaa aaagacatcc agcatcaaaa agatcagatc gaagtttacg 1782721 aaaaacagct gcagcaagga ttttctacag attatgacta tgatgtgttt gctgattctg 1782781 ttatcaaatg cgcatatggc gatatgacgc tggaagattt agaagccgtt tattatggat 1782841 tgacaacacc atttttttga tttgtcattc agcagtaaaa tttcaatttc tgtctcacta 1782901 acttaagtat actttgatat tgagacagaa atttatttat tttgtttact tcctagaata 1782961 tatattatgt aaactagaaa agatgaagaa taaagctttg ctgtttttat gtacatcctt 1783021 tcttcttcct gtaattcagc aacaaaataa aaaagcgatt tcccaatcgg aaaatcgcca 1783081 attcagacac tctattattt atgtgtgtct ttgtgctctt aacgatttac aacaaatgtt 1783141 gtcacgcttt gagctggaag atgagcccaa aaatgattgc ctgatacagt gagattcgtt 1783201 ccaggttgta gattgctgct gctgctcgtg atccatctag atacgtttga agcagatcca 1783261 ttctgcaaaa caaagttttg gttgactcct gtgttgcttt tattgatggc aacaataacg 1783321 accttgttgt cacctttata ggctgacacg taaacgttcg cattagggtt tttcgttgca 1783381 tcaatcctta catagccggg acgcacaaac tttgagaaat gagccatatt gtagccgcgt 1783441 ttgctgatcg taccatcttc tttcataggt ccatatgatc ttcggatgta ccaccataca 1783501 taagcttgaa agtccccctc taccatcgca ttgtgaatat gctgtgaaac atccaatgcc 1783561 tcaggccatc gatccgccga gttggtatca ctgtttggat agtatacttc cgtcatccaa 1783621 aggtccttcc ccgctccttt ttgtttgaaa agaggataag ggaattggct gacctgggtg 1783681 ccgtacaggt gagttccgag aatatccata ttggcaagag cctgcggatc gttcaagatc 1783741 gggtccgaca aattcttcaa gtattgaaat gactcaggcg caatgacgcg ggcattgatc 1783801 gagccggcgt tttctctcat aaagcgaagt atttcttgcg gcgtccacca cgtccactcg 1783861 tgagcgtaat caggctcgtt ttggaccgaa atcgcgtaaa gattcacacc attattcttc 1783921 atgaaggtaa caaaatcgtt aagatgctgc gcgtatgctg cgtacttgtt gtatttcagc 1783981 cgtttagccg atgtgtcacc attccgatta aaggtctcaa ccatatcact tggaggattc 1784041 caaggagaag caaaaacgat tgctccgtgt ttgaccgcac tctttgcagt ctccacctct 1784101 ttataccaat tatttcgatt ttcatctaca tgaattctta agattgaaaa tcctaactgg 1784161 ttctgtccat tgccaaaagc agtttctctt tgagctgctg taagatcccc agcccaagcc 1784221 ggatgattca tccctccaaa accgcgaatc acttgtttct ctgcagatac attaactgtt 1784281 acatcacttg ctgccaaaac ttcagtagcg cctggcccta acatgactga cagcatagtg 1784341 aaacatacta atagtacaca aattgttttt tttatgcgtg gaatcattta ttcctctcct 1784401 tcgtcatgtg tcttttacgg tattaaaaaa tctgcatggc atatccataa tggcgggctg 1784461 ttccggtgct ggcccgtact tcacccgcct cgtttttaag cggtcccatt acgagtacta 1784521 tctttgcgta aactgccagt aatcaaaatt aaacaagttt cctgtacctg ttccggtaaa 1784581 tacaaagaat actttgtgca caccggttgc cccgcttacc gcagtttcta tttccctcca 1784641 cgtttgcgct ccgcctgttg aaggcacatt cagagttcca acaagcttac cgtctgcact 1784701 gtcgaggcgc acttctattt tcccgcctaa agtggatgct acatttgctt taaatgacct 1784761 ggcaccgccc gctccgaagt ctgcatttcc tacagcaatc cagtctccat tttgaatgct 1784821 tgttacatgc tgattattta ctggcccgcc gggtgctgtg gacttctctg tcaaaatgcg 1784881 tccattccaa gcaaacgttt cagcttctac ccggttatat gggtttaaat tggaaatttg 1784941 tgttacacct gcataatttg ccgctacctc ttgaatagat ccatctgcat tatgcaccag 1785001 cttattaata tggggagagc ggtatccttt gccggccccg aacagagcgg aactgacagt 1785061 ttgcgcatgg tacaccacat accactcgtt tttaaaattg aaaacagcat gatggttgtt 1785121 tccgccacct ccgaaaaatg cacccggatt tttcaggaag tgccctctat atgtaaaggg 1785181 acccatggga cttgaactgg tcatgtagcc gatctcaccc gggggtttat cggccgggtg 1785241 cgtgccgccg aaattgatgc aataggagta ataatatgtt ccgttatact tgtgcaatcc 1785301 cgaatcttca aacatgaaag gcgcatcaat tgtagatgca cttccaacaa cactcgtcat 1785361 atcaggcccc aattttatga ctctagccgt tttaggattg gcccattgtc cctgcgttgg 1785421 atttgaaacg ccaggaacgc ctccgccggc atacaggtaa ccggttccgt cgtcatctac 1785481 aaatactgcc ggatcaaaaa gccatacaac accagacatt cctggcgtac ttggcgttac 1785541 gagcggtttt ccgattgggt cggtccatgg accaatcggg ctgtctgcgg tgagaacccc 1785601 gatacctccg ccgctgtttg cgaaataaag gaagaattta tccttgccat taattttttt 1785661 aactgcgatt gacggtgccc atgacgcacc tgcccatttt gcaattccac ggcctccatt 1785721 agctccattg gcacctgcta ccggaatggc tccgtggtct gtccagttca ccatatccgc 1785781 tgaagatatg acgaatactc tattcaaatt ggcaaatgaa ttatctttaa ttgttccgtt 1785841 gctattatat tcatagtcat cacttgacat atagatgtag actcttccgt tataggtcag 1785901 cgcaaccgga tccgctccca aatgatggtc gataagcgga tttgaattcc ctatatgttt 1785961 tgcaattgta gtactagtgg cagcatacgc agacttccca gataagcagc tcaataataa 1786021 aactagaatc cataaacata cgctacactt tttcctcatc acttcacatc ctcctttttc 1786081 cttaaaatgg gggattttct tttggaattt gataacaaca ggtcacgaag attgcacgca 1786141 taaagtagcc ggaagctgtt tagcaatgtt cccagttgtt ctgaaagctc atcttcatgt 1786201 gtctccattc tctcttttct tcgaggagat cgcaccactc cttcaaaatt gttcaaaaaa 1786261 acttccccat tcctagcgac cattgtccag aaaataaaaa gacaggattg ttcatggcct 1786321 cccactaatc acattgaacg gagattacat cattatccaa gatatccctt tatctaacat 1786381 cctacatcat taaaaaaatt gtgtatagaa acttttggag gagttagtgt tcgattctac 1786441 aaaggaactg gatacattta ttcattgata agatggggct aacactccgt ttatatttgt 1786501 atgttttcag acacaaaaaa cagccgttca atgcggctgt ttttttcaag agtataagac 1786561 tattgagcgg tatacccgct ttttcatgtt ttgttcatat tttattaatt gtttattcaa 1786621 cactgtccgc tatagtaatc catatcaaca aatatgactg ccactcgcat cttttatgaa 1786681 gggaggttcg ttacgctgaa agaaaaaata aagacattag gccgtttttg caccgtaggc 1786741 gtcggcaata cgctgataga ttttggtgtc ttctttcttc ttaccgcttg tcatgtctct 1786801 tatctgccgg cgcagatctg ctcctatact gcaggtatcg tcaacagcta tgtgtggaac 1786861 cggaattgga cgttttgtgt gaaacgtaag gctgacggga aagagatcgt gcgttttctc 1786921 atgattaata ttgccgcgtc agggatcacc tttttgctgc tttatttgtt tcaaaattgc 1786981 ggctgctcgc ttttggtgag taagctcgcc gccactatcg gcggaatgat gatgaatttt 1787041 atcggaaacc gaatctgggt atttggagat tcgctgaaaa acatacagga tcaggagtga 1787101 agatgaatga gaaaaaaagt gagaaaagcg gttatacccg cagcgggttt aggaacgaga 1787161 tttctgccgg cgacaaaggc gcagcctaaa gaaatgcttc caatcgtcga caaaccagca 1787221 atccaatata ttgtagaaga ggccgcagag tcaggaattg aagatatact gattattaca 1787281 gggagaaaca aacgctcgat tgaagatcat tttgatcggt cggcggaatt ggaattcaat 1787341 ctccgggaaa aaggcaagac ggagacactt aaggaaatgc agcagattgc cgatttggcc 1787401 aacattcatt acatccgcca gaaagaaccg ctcggattag gccatgcggt gctgtgtgcg 1787461 gagcatttta tcggagatga gccttttgct gttctcttag gtgatgatat tatggtgtct 1787521 gaaacaccgg ctcttcggca attaatggat gtatatgacg tttatggcac agaggttgtc 1787581 ggtgtacagt cagttctccc tgaggatgtc agcaaatatg gtattataaa tacatcaggg 1787641 tctcaagggc atgtatatga agtgaacgat ttagtggaaa agccttctcc tgaagaagca 1787701 ccttcggaaa tcgcagtaat gggacgttat gtgctgaatt cttcgatctt ctccgttttg 1787761 aagacaattg gcagaggcgc gggcaacgaa attcagctga cagatgcgct tcgtgaggtt 1787821 tgccgtaagg agccgatcca tgcccggctg ctggaaggaa atcgatatga cattggcgat 1787881 aagctgggct gttttaaagc gagcaccgaa atcggcttaa tgcgtcccga aatgagatct 1787941 cagcttttgg cctatttaga agatgtgatc aaacgggaaa cgaaagaaat gctgcggtaa 1788001 aaaaattgta accatcttgc tcgtcaatca gtcatataat agtgaaaaag attaggacag 1788061 gttgtgaaga atgtgggcag tttgataagc gaaattttaa catggctgac gaacatggga 1788121 tatgcgggta ttgcgattgg gttaatgatt gaaatcattc cgagtgagat tgtattagct 1788181 tatggcggct atatggtatc ggagggcacg attggattta ttggcgcaat tattgcgggt 1788241 gttatcgggg gcaccattgc ccagatcttt atttactgga tcggtcgcta tggcggcagg 1788301 ccatttctgg acaaatacgg gaagtattta ttgattaaaa agcatcatat cgatatgtcg 1788361 gaaaactggt ttcagaaata cggcgccgga gttgtcttct cggctcgttt tataccggtt 1788421 gtcagacatg ccatatccat tccggcaggt attgccagaa tgccttttct caaatttgtg 1788481 gtactgactg tgcttgctat cattccatgg tctatcctgt ttgtttattt aggcatacag 1788541 ctaggaagcc agtgggatga tgttgagaat atagcaggca cttatacaac accgattatg 1788601 atattggctg ttgtcgtgat agccctttat tttgtgatta agaaacgtac agccatattt 1788661 aaacgatagc tagcggatat gcataggggt gactgacgct cccctatgca tattttttta 1788721 cttgcgatgt tgatttgcca gcttcagatt ctccgctaaa aatgcgacaa acacttcatc 1788781 ccgcacgagc gatgcggcat aatttctctt aataaaccat tctgcctctt caaacgctgc 1788841 gaatgtttcg tcttgggttt ctccgttaat ttgaatattc cattcgttgt ctaaagggaa 1788901 aagaaaaaat ctcatttgtg cgcgattttc atataatgat ccattcgcag atccctttag 1788961 attatagatg ttacggaagg catccggccg tacaggatca atacggaaag cttcagctac 1789021 aaacaactcg tatacttcat cggttattga acagccggac gcttttgcat gccctccgcc 1789081 gccatatcgg ccggcgattt ctgacacatc gatgtaatca tgaatggtgc ggagactgac 1789141 tcgttttgac cccatgctca aaatcgcaat gtaatcgagg tgcgggttat ctttccctag 1789201 cctgttcccc agctctgaat ggtacgattc agcgtgaacg atgcctacac agtgttcgtg 1789261 aacaaaggtt tgtaccattt cccttttctt tctgcggagg tagcgctcga ttttttcgtc 1789321 ttctaaatca agcagttttt cttcaaaatc atcgaagaaa aattcgtcat gcgtggaaag 1789381 gcgctggatc atttttgctt caaattcatc gattgacagc aaaaagaaaa gatcattaag 1789441 ccgcttcgcc tgtttttgat cgtaccgctc ccactcccat gtatcgtatt ggcggacgag 1789501 ctctgtgaat tgatctaagg cgtttgtcgg tttcatgaag ccattttcaa tgagatagcc 1789561 atataaaagc gatgtcgcgg atgtgagcct tccatcatcg tattccacct ggacaaatcc 1789621 ccattcatgc tcattcaaat gaagggctgt tttatgatgg tcaatgagct tcactttgcc 1789681 ccctgcatga acatactcat tcaatctctc ttcgttttct tcattgacgg cgagatcggt 1789741 gatgaataac gcgtcctgtc tgttgctctc cttcgctttt tctaaaaagt actgcacctg 1789801 tgcgtttaag ccgttgacag agttataccg gatctctacg tcttttccga acgccaattt 1789861 tgctacgatt ccgcatccta ctccgtccaa gtcgttatgt gaatataaat gatacataat 1789921 gtaggcccct ttttatgata aactgacaat tgccgctaga ggtgcggcag cctttattta 1789981 ctattctaaa aaaccaagcg ttttatgcaa tggtaattag ttgacataat gttgttattg 1790041 taaatatata aaggagcgct ttttttgcgc tcctaagttc ttgcttttac accggataaa 1790101 ccggatgctt tcgattggta aatgtcattt cctttgtcat gtatgccttg agccgtttgg 1790161 ccagctcatc acgcagcgaa ttggctggga taacagcatc aatgatcatt tctgaagcca 1790221 gacggtagat attgatgtcc tctttgtatt cctcccgttt gctgctgata aatgcggctc 1790281 tctcttcttc tggcagctcg gcgatttttt tagcgtagac agcgtttaca gcggcctcag 1790341 ggcccatgac ggcgatttgg gcggttggga gcgctagaca gcaatccggt tcaaatgccg 1790401 gccctgccat tgcatacaac cccgccccgt aagcttttcg gacaatgaca gagagttttg 1790461 gaacagttgc ctccgacatc gcagaaatca ttttcgctcc gtgtctgata atcccagcct 1790521 gttctacttt tgtgccaatc ataaaaccgg ggatatcggc taagaacagc aatgggatat 1790581 gaaaagcgtc acataaggta ataaacttag ccgctttgtc tgctgaatcg tggaataaga 1790641 cgcctccttt taccttcggc tggtttgcaa caatgccgac aggctgtccg tggattcgtg 1790701 cgaggcccgt caataattcc ggtgcaaata aggctttgat ctcaaaaaat gagtcttcat 1790761 ctatgacccg ctcaatgagc tcatgcatat caaaaggtgc gttttgattt tgcggaatga 1790821 cgtcggcaag cggagtttcg aagtgttttg gcgggcgttt ctcatgaatg ggcgcttttt 1790881 cttgaaaatt tgccggaaag taagacaaat aagcccgcac cagctgtatg gcttcttctt 1790941 cagtttctgc aagaatatct ccgcagccgg agattgagca atgcatacgg gcgccaccca 1791001 tttcttcgag agacactttt tctccaataa ccatttccgc catccttggc gaacctaaat 1791061 acatggaggc gttaccgtct accataacga cgatatcaca gaaggccgga atataagcgc 1791121 ctcctgccgc agatggtccg aaaagcagac agatttgcgg aatgcgtccc gataatttga 1791181 cttgattgta aaaaattctt cctgcaccgc gtctccctgg aaagacattg atttggtcgg 1791241 taattcgggc gcctgccgaa tcgactaaat aaatgagcgg acagtttaat ttttcggcga 1791301 tttcttgaat tctgatgatt ttttcaactg tttttgctcc ccatgacccc gctttcactg 1791361 ttgaatcatt cgccatgacg caaacggttt ggccgccgat tttgccgata gcggttacaa 1791421 ctccgtcagc gggaagcccg tctgacatac attccgcaaa aaaagcgtct tctagctcaa 1791481 tgtcatcgtc aaagagaagg gaaagccgct ctctgacaaa gagcttgcct ttttcccgat 1791541 tgctttgatg atacttttcc gctccgcctt ttcgaatccg ttcagcccgt tctgttcgtt 1791601 ccttttcata atccatcagc attgcctccc ttttatattc ccttgtatac ggcccgtctt 1791661 ttttcttgaa aggcctgaag cccttctctc ctgtcttttg tcgggatggt ttgttcatac 1791721 gctttttgtt caatcgcaag gcctgtagca agatctgtct ccaatccttt attgattgca 1791781 aatttagcct gacggacagc gatcggtccg ttggcagaaa tggctgcggc cagttcctct 1791841 gcttttggca taaggtcaca aggagccgtg acatgctcta caaggccgat ttcttttgct 1791901 tcgtgtgcgg tcacgcgtct gcctgtataa atgaattctt ttgcttttcc tctgccaatc 1791961 agccggggca gcctttgggt ccctccagcg cccgggataa tagctaaccc tgtttccgga 1792021 agtcccagca cagctgcttc agttgcgatt cgaaggtcgc atgccaatgc caattctagt 1792081 ccgccgccta atgcgcttcc atttatcgca gctatgaccg gctgcggcaa ggcatcaagt 1792141 aaagccgccg ttctttgaat gagagataca ctttccagaa cctgatcttc tttcagtttt 1792201 atccgttcct tcaggtctgc ccctgcacaa aacgcttttt caccggtgcc tgtgaggatg 1792261 acgcaacgga tgtttgagtt aaattcaatt tcctggataa tcatttgcag gtttctaagc 1792321 atttccgctg aaagagcatt tgctgcctga ggcctgttta aggtgatcaa cgccatatgt 1792381 tcatttttaa cagtaaaaag aatagaatct cccattgtat gcgtcctccc ttttatcaag 1792441 atgatttaaa cacctgtaaa tttctgctcg gcagcggttt gcccattttt tcttcaatcc 1792501 atttggccgc agatagcagt ttttctagct ttacatttgt tttgatatcc atctgttcaa 1792561 gcatgtacac gatatcctca gttgcggcgt ttcctgatga acctggcgca tatgggcatc 1792621 ccccaagccc gcctgccgag ccgtcgaaca ccgtgatgcc catttggagt gctgtgacca 1792681 tgttggccag agcggttcct ctcgtatcat gaaaatgcag ggcaatttga ttagccggga 1792741 atcgtgccaa aagagcttca agtacagttt ccacttgggc gggattagct gctccaatcg 1792801 tatctccaag cgacagttca gaaatcccaa attcaaatag agcttctgaa aggcgaatga 1792861 cttgttcaat ggggacatct ttttcgtacg gacagccgaa aacagtcgag aggtaggctc 1792921 ttgttgtgag gtttgctttt tgtgcgtcgt tgtttacttg tttgagtata tggagggatt 1792981 cagaagtgga tttattgatg ttttttctgt tgtgcgtctc gctggcggac ataaaaacgc 1793041 aagcctcgtt aatgcctcct tcaagtgcat tctccagtcc tctttgattc gggacaagtg 1793101 ccgcgtacgt tacccctttt tctcggtcga tgccttttgc tacatcgata gcatctcgaa 1793161 gcgccggaat ccatttcggg tgaacgaagg atgtgatttc aatatacgac agccctgtcc 1793221 gggaaagctg gttgatccag gttattttat cctctgttgc gatccaaacg ggctcgtttt 1793281 gtaagccatc acgcgggccg acttctttga ttgtcacttt tttaggatat ggcatggtct 1793341 tcctccaaat tattgagtgg aattgctcag ttcgagcagt acgtctcctt catttacaaa 1793401 gtcgccttcc ttttttttga cttcttttac gattccgctt ctatctgcaa cgatcgggat 1793461 ttccattttc atcgattcca aaatggctac ctcctggccc ttttcgattt ggtcgccggc 1793521 tttgacgtgg actttccaca ggtttcctgc catttgtatg ctaaccgtca tgacaactgc 1793581 ctcctttata ggtgctgttt caaaaagtca gtcgtgacat ccccttcttt aaatgccttt 1793641 gttgccgcag cctgtatgag gagcggaagg tttgttttga ttccctctac acgatagtcg 1793701 cgaagcgctg tctctagttt ttcaattgct tctgttctgg tttggccttt gacaatcatc 1793761 ttagcgatca tcgggtcata aaaaggggta acggtgctgt cttttgctac cgcacattcg 1793821 tgtctgactc ctttttggtc aggaagtgaa aacgcagtga tcgtacctgg tgacgggaag 1793881 aaggtcttgg gatcttccgc gtatattcga acctctatcg catgcccgtt ccgttggatg 1793941 tctttttggg agaatgtgag tgtatggccc gcagcaatcc gcagctgctg ctcaactaag 1794001 tccaggcctg ttatttcttc agtcacgggg tgttcaactt gcagtctcgt attcatttcg 1794061 aggaaataaa aattttgttt ctggtcaact ataaattcga tggtgcctgc gttcgtatag 1794121 ccgattgcct tcgctgcttt taccgctgtt tgaccgatct tcattcttag ttcatcgtct 1794181 acaaatggag acggtgcttc ttcaatgact ttttggtggc gcctctgaac agagcaatca 1794241 cgttcaaaca gatgtactgt atggccgtgt tgatcggcca aaagctgaac ctcgatgtgg 1794301 cgcgcatgtt caataacttt ttctatatac atagacccgt caccgaaaaa atctgctgcg 1794361 cgctttttgt ttccctcgta cgcttttttt aatgcttctt cattttcaac acgctgcatt 1794421 ccgatgccgc ctccgcccgc tgaagctttc agcatgacag gatagccgat ttgacttgcg 1794481 gtgcggcagg ctgcctctat atctccgagg gattcagaaa cgcccggcac cacagggaca 1794541 cctgcagcct ccattgcttt tcgcgcttca attttgctgc ccatctttgc gatgatatca 1794601 ggggaaggtc cgataaacac gatgttttct tgcttgcagc gttcagcgaa ccggctgttt 1794661 tctgataaca atccatatcc cgggtggatc gcgtcggctt ttgctttttt cgccgtcttt 1794721 atgattctct ctatatttaa ataactttca ctgactctcg attccccgat caaatatgcc 1794781 tctgtagcgg cttttgtatg gggcgcgtcc ttgtctgctt ctgaataaac agcgaccgtt 1794841 ttaatgccga gacggctgca tgttcggata attctcattg caatttcacc gcggttggcg 1794901 atcagtactt ttgtaaacat gatttcacct cattgacttg atgataagtt gaacatttca 1794961 atcgtttttt ctcgcagttt atatttttga attttgcctg aggccgtcat cggatagtca 1795021 tccgtaaaaa taacataacg cggaattttg tggcgggcga ttttcccttt gcaataggct 1795081 ttaagctcat caggtgaaac gcttttaccg tctttcagtt taatccaggc tgcagcttcc 1795141 tccccgaatt tggcgtcagg cacaccaacc acctgtacat ctaaaacagc gggatgctgg 1795201 tataaaaatt cttcaatttc ccgcggataa atgttctcgc cgcctctgat gagcatatct 1795261 tttaatcttc cggtgatgcg gcagtacccg tcttcatcca tgacagcaag atctccggta 1795321 aacagccatc cgtcatgatt gattgctttt ctggtcgcat ctttgtcttt ataatagcct 1795381 ttcatgacgt gatagccacg ggtgcacagt tctccctgca tgcctctttg aacttcttga 1795441 catgtcccgg gttctacaat tttcacctca gtatgtggca gggcacggcc ggttgtttcg 1795501 actcttctta tgaaggaatc atttgctctc gtttgtgtaa tgactggcga ggcttcggtt 1795561 tgtccatagg cgatcgtaat gtctttcatg cccatccttt caatcacagc tttcatcact 1795621 tcacttggac agggagagcc ggccatgatt cctgttcgga gcgtcgatag atcatatgca 1795681 tcaaaatccg gatgatgcag ctcggcgata aacatggtag gcacaccatg gagcactgtg 1795741 catttctctt tttctaccgt tttaaggacg gtaacgggat caaattcttg cacgggtatc 1795801 atggctgccc cgacggatac acatgccaaa accccaagga cgcatccaaa gcagtgaaaa 1795861 aacggaacag ggatgcacat gcggtcttga gaggttaaag ccatacattc agcgatatta 1795921 gcagcgttat tgatgacatt gaaatgggtc agcatcacgc cttttggaaa ccctgtcgtt 1795981 cctgatgtgt attgcatatt aatcacattg tctttatcca ggctgttcat tctctcttca 1796041 agctcagcat ctgtcactgt tttcgccaat atctctgtat cgtcccaatg atacatgcca 1796101 gacaatcgtt tattgccaat atagatcagc gtttttaaaa agggatagcg ttcagatttc 1796161 agttggccgg gctttgcttc ttgcagttct ggaattaaac tgttcacgat gtctggataa 1796221 gaagtgcccc tgtatgaatc catgataata agcgccgcgg catccgattg ctttaacaag 1796281 taatcaagct catgtgcttg ataattggta ttgacggtca cgagcacggc tccgatcttc 1796341 gcagttgcga actggacggc aagccattca gagatattag aagcccatat ggcgacgtgg 1796401 tctccttttc caatccccat ccgcatgaga cctttagcgg tttgacggca cagactgtca 1796461 aattgagcgt acgtatagcg gatatttcgg tctggataca caacagcatc tcgatcggga 1796521 tacgcatcag ctgtttgttc cagcagcctg ccgattgtgg aatggatgag ttcagccatt 1796581 cattgttcct cctttcttaa tgataggaaa gcgtttacat ttttatttta aaagctgtct 1796641 ggcgatcacg agacgctgaa tttcagatgt gccttcaccg atttccatta attttgcgtc 1796701 ccgcagcatc cgttccaccc catactcttt catatagcct gaacctccat ggatttgaat 1796761 ggcttgattg caagctcttg tcgccatttc agatgcgaat agcttggcgt acgccgcttc 1796821 tttggtgaac gggcggttat gatctttcag ccaggcggct tttaacacca tttgccgtgc 1796881 cagatcaatt tccatcgcca tgtcagcaag cttaaattga atcgcttgaa aggaagaaat 1796941 cggctgtcca aactgctttc gctctttcgc atatgccaat gatgcgtcaa gggccgcttg 1797001 ggcaatgccg actgcaagag cagcgatgga gattcgacca ccatccagcg tatatagaaa 1797061 ctgtttaaac ccttttgttg gatcgccaag taagttggcc gcaggcactc ttacatcttc 1797121 aagcaagatt tccgctgtat tcgaaccgcg gacgcccatt ttatcgtacg ggctcgtaat 1797181 cgtaagtcct ggtgtgtcag ttggcacgat taatgcggag atgatgtttt ttccgtcttt 1797241 gtttttgcct gttacggcgg ttacaataac tgtgcgtgcg tagcttgcat tagtgatcca 1797301 gcacttttcg ccgttgatta catactcgtc accatttgaa atcgcttttg tttgagtgcc 1797361 tcctgcatct gagccggcat ttggctccgt caggccgaat gatccgagtg ctgtgcctga 1797421 agccagcggc gtcaaatgcg tctgtttttg ctcttctgtt ccgaagtagt aaagagggct 1797481 tgcgcctagc gagaccgctg cagcatagct taatccagta ctgccgcagg ctttgccgac 1797541 ttcttcaacc gctaaggcat atgaaatcgt atcaccgcca gatccgccgt attcttctgg 1797601 aaatggaata cccatcagac cgagttcacc cattttttta aatgtttgca tcgggaactc 1797661 gcctgtttga tctacatgtt cagcgtgagg agcaatttct tttttcgcaa aatcttttac 1797721 catttcacgc accatttgtt gttcttttgt cagctcaaaa ttcacatcgt ttcctccttc 1797781 acatctttgt aacatcctat taggcgagtt ctataatcat tccctgacaa gaaaagtctg 1797841 aaaattaaaa ctgaatcatt ttttatgtga taatatcagc gggatgagca aatacatgca 1797901 gtaggcgcat accatccata tcgtaaacgc aataacttgg ccctttgata aagccgggaa 1797961 gatgagggga agattccaaa gggaaatcgt atccatcaat aaaccgaccg ctgatcccca 1798021 tatacctagc ttgatcaccg cgaactgtga ttgatcgagt ttttgataga gaaagaacac 1798081 aaggcataaa acaagagcag tgcccgctcc caagagaaga aagttcggca aaaaggcttc 1798141 ttcagccgga tcagtcaaca cagcatctcc gaacagcaca aaaaataatg tggcacctaa 1798201 ccagactaga aatgaaaacg taaaacacgt cctgtacgtg tttctcttcg attttatttt 1798261 tatttagtac tagtttctca gattccaata atggtaaatg tccaaacacc gcctccatat 1798321 tcatgtgaat ctcacctttg ttttttaaaa aattcagcgg tttaccatcg tttcctgtcc 1798381 caaaatcact ttttaaaaaa agacgactta gaaagccgtc cttctcattt cttattttgt 1798441 tgttcgtttg gaagctttgc tttcgttatg aagccggtct gctgaagtga cataatacgt 1798501 atatttcttg ttgggatctg ccgtgttatc taagaaggtt tgctgctcat gtgtttttct 1798561 ttgcgttgcc agcaatgttc tctgcttttt cccttcggct ctgtatatcg cataataggc 1798621 tgtttctttc gttttttgat ttgatgggtg atctttaatc tgcagaagat tgccgttttt 1798681 gtcttcggtg actttcgtaa gcttcggttt ttttggggcg gtattgtcaa gccaaggcat 1798741 ttgcggaacc agtgccggct tgctgtaaag atcggtgctg agactgtctt tgatgccaag 1798801 cggatttttg ttgaggtcct tgaggctgaa atgcatgctt cctttcacca gttcaagctg 1798861 gcggttcaaa gtgatttgcc gcacatattc ctcaggatcg gaccaaggcg gatcaaaatt 1798921 gttattgatt ttatatgctg cctggccaat atataagtga acaggcctat ttttgacttc 1798981 attgctccac caatcagcca gcacgtcgta agccgctgcg ttaaagccga tactccaata 1799041 aatttgcgga gcaatataat cgatgtcgcc ttcttggatc caatgccttg tgtctgcata 1799101 tagatcgtca taatttctga cgcctgcttt tgtattcgat ccggtcgggt catctgcggc 1799161 gtttctccat actccaaagg gactgatgcc gaatttgaca tacggttttg cagctttaat 1799221 tgtttggttg atttgtttga caagctggtt cacattgtcc cgccgccagt catcgatatt 1799281 agaaaaagcg tcttttccgt attgttcgta ctgtgcttga tcaggaaatt cctgtcccgc 1799341 tattttataa gggtaaaaat aatcatccat atgaacagca tcgatatcat aatgttttac 1799401 gacttcttca atgcctttga cgataaaatc tctcgcttct ggaatgcctg gatgataata 1799461 cagctggttt ccataggcgg caacccaatc tggatgtttt cttgccgggt gatcctcaga 1799521 caatttatta agatctgtat gattcattgt aatacggtaa ggattaaacc acgcgtgaaa 1799581 ttccaaattt cgtttatggg tttcttcaat cataaatgca agaggatcat agccggggtc 1799641 cttcccttgg acaccggtta agtattccga ccaaggcccg taagctgacg gataaaaggc 1799701 atcagccgtc ggtttaatct gaacgataac ggcattcatt cccatttttt gcacatcgtc 1799761 cagcagtttg atatactcct gtttttgctc tttcacagat aacccttttt tggacggcca 1799821 atcaatattt aatacggaag caatccatac ggctctcagc tccctgtcag actgcgcatt 1799881 ggccataaac ggaacggaaa tgacaaacgt tccgatgatc aagctgacaa ggaaacggac 1799941 aatcgacttt tggcaaacct tcattctgtt tcttctcccc cattacatca ctttcactat 1800001 tcgctattac ggtattcccg ggctataaaa gggtgattaa cagaatgtct atctcactaa 1800061 ataaacgaaa aaagtcctaa agcatgttgt gaaccgcttt taggactttt tatcattcat 1800121 catggtttgc agacttttta acacatcaat aagttttacg ccgacaccga cagccgtttc 1800181 aaggatcgct tgtgctccgg caatggctaa aataaagatc agcggtattg caatacgagg 1800241 caaaaaaaga tagccaagtc cgatcaagat ggcacaccaa acaccggcac accagtagca 1800301 attgagcatg tatccaaagt tagaagccgg cacgcttttt tcatctacat gcccgttttg 1800361 atcaacaatc cttttctttt tcataaaagg ttttcggata aattctgtga ttttgtcaaa 1800421 tacaatcaaa tgtgtcagcc tgtaactggc tagaatcagc atgataaaag ttagaaaaga 1800481 aagacggtcc attgagaagc ctccaagaaa aaggatgatg ttatcattcc caagtgtccc 1800541 ttatccattc ttgatacaaa aagaaagacg gacagagaat ggcctctgtc cgctaatccg 1800601 ctttatcgtt tgtgcagtat tacttgattt gaagtgatct tttctaaaat gtcgaggatg 1800661 atgtcggcat tcttttcagc atatgttcct tccagcatgt ctttatgagc gccaaaaccc 1800721 gtgtactcac tatagtttcc gcaggcgcct tcccatttcg ttaagcctgt atgcccgctg 1800781 gtttcggggt ggattccagc ttcgatgaaa tgaatgcttg ctttgatgtg gccttcattc 1800841 agcaattgtg cccaatattc ctgatagttt ctttttttct tcatcacctt ttctctgact 1800901 gcttcaggca gatatgctgc agattcgtca ttaccggtat cgataggcaa aggctgttct 1800961 tttagataag cgtccacgat aatgaagtcg ctgacttcta atcctttgcg ctccatagcc 1801021 tgtgccactt caaaagccag gtttccgcct gcagagtagc ctaataaaac gtatgggccc 1801081 tcaggctgta tgtccgtcat gcaattaaca tattgttcaa tgcgggtgtc ttgttcaata 1801141 aagtgaaacc cgtatacggc tgccttctca ttcagcaata aagcaaggtc tttaaaataa 1801201 atgccaaatc ccgatatcgg cgggaagcag aaaagatttt gcgcgccgtg ctggttcagt 1801261 ttgatcacat gctgttcatt tgctgctgtc agctgtttag aataaagttt ttcggcaagc 1801321 tgagcgattg tcggatgttc gaacaagaaa tcaatcggta tgtcaatgtt ctgctgatgt 1801381 tttagtgtat gtatgacttg cagtgctctt agtgaatgtc cgccaatagc aaagaagtca 1801441 tcatcaatac tgattgtgtt aacaccgagg acttgcttcc aaatgttcgc caattcttct 1801501 tcaaccaagt ttcttggcaa tatgatgttc tgtcgtttgg caggcttatt ttctggaata 1801561 ggcagcgcgc tgcggtctat ttttccgttt ccggtaagcg gcatccgctc cacacgcacc 1801621 cagtgctgcg ggatcatata gtctggaagc acacgcgcca aatcggcgcg aaaatccgta 1801681 tctgtttttt tgtgatcacc gacgtaatga gtgtacagct gcgcctctcc atctttttct 1801741 ctcaatgtca ctgctgcttc ttgaacgcct tccatttcta acaggcgcgc ttctatttcg 1801801 gcaggctcaa ttcgttttcc gcggattttc atttgcctgt caattctgct gatgtattct 1801861 aagtttccat caggcagcca gcgcgccaaa tcaccagtac ggtatattct ttctccaggc 1801921 aagaaaggat gaggagaaaa cacagcattt gtcagatcta ctctgttcaa atagccttta 1801981 gcgactccat caccgccaac acaaagctcg ccgggaacgc ctattggcaa aagacgtcct 1802041 tttgtatcta agatgtaagc ggtgctatta ctgattggtt ttccaatcgg aatcggcccc 1802101 gcatagtctc tcttcatttc aaaaaaggtt gaaaaagtcg tgttttccgt tggcccgtaa 1802161 atattatgaa gcgcgagatc tggacaggcg tgtctgacgg cattcatcag ggcaggagag 1802221 agtgcttctc ctccgacata taacgtatgg agtccgcgaa acatgtcagc tcgtacctgt 1802281 gccagctgat taaaaagagc tgtcgttaaa aatagcactg taatgtcatt ttcaagcaaa 1802341 tacgctccaa accgatcagg tgtcagcatt gtcgatttat caatgatatg aaggcttgcg 1802401 ccatttaaaa gtgccccgaa catttcaaag gtgacggcgt caaagctgat agatccagtc 1802461 ataataaacc ggtcatcacc ggacgcagac gtgtaattgc tgtttctgac aagggacacg 1802521 acattgcgat tcgtgatcat gacccctttc ggccggcctg ttgatcctga ggtatacatg 1802581 atgtacgcaa gatcatccgg gctggagctg atattaatag ggatatcgtt ctcttccatc 1802641 aatccctgcg catctgaaat gatacatgtt cctgagaacg cagcgttttg ctccaatccc 1802701 ttttgaacaa tcagcatttt tgcctgcgtt tcctcaagca taaagctgac tcgttcaggc 1802761 ggaagctccg catcaagcgg gaggtatgct ccccctgctt ttaatacggc aagcacactg 1802821 atcatgaatt cgggagaatg tgcagccaat attccggctg tctcgttttt ccgaaatccc 1802881 ttttgaatta actctctggc gagcgcatta gagcgtttat caagctcttt atacgaaata 1802941 gacatattgc catacacaag tgcggtatgg tctggcgtct tttctgcttg ttcgcgaaat 1803001 aaatcgataa ttgtatgatt ctttggatac tccgtttttg tattgttgaa ctgtgtgaca 1803061 atctgctctt tttctgttgc atcaagaaaa gaaaaatcag caattggcat atgagggtgc 1803121 tgtgcagctg tgctaagcgc ttgcgtaaat tgcctcttga tacagctgat ccaggcagca 1803181 tcgtaaacga atgcattata gctgaacttg atgacaagct cttcgccagg agcaacgaca 1803241 agattaaagt tatatcctga ttgctcggat acttgaactt gatcgatttg cagcggtgaa 1803301 tcggtttgat cagcggaatc ggcgattttc tgctgtaacg gatagttttc aaagacgata 1803361 atgtgatcaa tcagttcctg ttttaatgcg gtgtttgcct gaatatcaaa taaaggctgg 1803421 caggtaaacg gctcagcttc cagcatttct ttctggcagc gtatgagcag ctcgtgaaac 1803481 gtttcgtctt ggtgtgtttt aattcgaatc ggtatggtat tgataaacaa ccctatcatt 1803541 tgctccacgc ctgggatttc tgacggtctt cctgatacaa ctgcgccaaa cacaacgtcg 1803601 tctgtgcggt tatattgctg cagcatcaca ccccagactg cctgaataag ggtagcgagc 1803661 gtgacgccgt gttgtttggc agtctctttc agcttgtctg tcagtggttt atttaatgaa 1803721 aatatcaaat cttcacggtg ataactttct tttgtttctt tatcagacac acgaggcaga 1803781 ggtgatggag cgctgtagtt ttttaaatag gtatcccagt aggccgctgc tttttctttg 1803841 tctcggtttg tcagccatga aatataggtg ctgtacggac ggacagggtc taatgaaagc 1803901 ggttttcctg catgaatcga ttgataaatt tgcataaatt cctgcataac gatacctagg 1803961 caccatccgt ccattaaaat gtgatggtga ctccagatac agacatgctc atctttagct 1804021 gttttgaata gagaaatccg catcagcatg tctttttgca gatcaaagcc tttttgcttg 1804081 tccttctctt taaagcgttc aatatactca ttctggtcgt ttgtcggcag atgagaaatg 1804141 tcttcgctgt tcaaatggaa ttcacgttct gtcatcacga cttgccgagg tcccgacaaa 1804201 tgcgggacgt gcggcaaaaa cacggttctg aaaatatcat ggcggtcgat aatggcttga 1804261 atgctgcgct ggaaccagtc atagctgagg cttcctttaa tggtgaagag cgactgctca 1804321 acatacgccc cctcctcttt acggaggaag gaatgaaaca gcatcccttc ctgcatatga 1804381 ctcagaggat aaatgttctt gattttttta atggtattca tagtgtctgc acctttcttc 1804441 acggattcat tagtgaaaac tgagcatatc agcgatctct tgcagggcgt cctcggtcag 1804501 ttcttgatca tcaaaatcac tgatcgtctt ttctgtttcg cttttgttct ggcagtgttc 1804561 gatcagctgt aataaaaatt gacggcatgt ttcgctaagc tgttcgatgg ttttgcgctg 1804621 aaagcgggca ttgtcataag tcatattgac agtcaatttt ccttctgcag cgattgcgct 1804681 gatatccagc gactgttcac ggttccatgt tgtgctgata tcacctccgg cacccagcgg 1804741 agagaatgag aaggcgtcct cctcaggtac ttcagctgtg cggccgcttt caaattgacc 1804801 aagataatta aagctgattt ctggtgcacc tgtgaaattg atgtcttttt tgccaggcgg 1804861 agtcaaatat ttgatgacac cgtagccgaa tcctttgtca ggtacacgtc tcagtgtatc 1804921 ttttgttgtt tttagcacat gaaccatgct ttcttccgaa tctggcaagt ctgcgttcag 1804981 tttaatcaat aacggataaa tggcggtaaa ccatccaatc gtccggctca catctattcc 1805041 ttttaataca tcctctcgcc cgtggccctc taatgatagt ttgaaggcgg attgattggt 1805101 ccaatggcgc agcgcaagaa tgacagaagc gagcagcatg tcctgcgtat cagtgttata 1805161 tgcgctgttg gcgtctttta agagtgctgc tgtctcttta tcgtttaagg taaacgaaat 1805221 tgtggaccgt tgtccctcgt gtgctctagt tccatcgatt tgatcaaaag gcaatgcctc 1805281 tgtttgatac tcttcggctt cgcgccaata cttgagctgt ttcattagct gctggctttc 1805341 agcgtagtca gagagctttt tcgcatacgc tttaaacgag cttgttttag gcggcagttt 1805401 gatatcctcc ccgccagcag cttggcgata ccctaaagcc aaatcttcaa gcagaacccg 1805461 ccatgagatg ccgtcaacga cgaggtgatg agcagataaa aataagaaat caccgtcaat 1805521 tgtgtggaaa agaccggctt gcagcagcgg accattcttc aaatccattt tctgctgaat 1805581 atcaagtaca tggcgcttga taagaggttc atacggtcta tttccatcag tgccgtccgg 1805641 agctgacaaa tcaatcatct gaaggccgta caacgcgtcg tccgaatgac tgagcggccg 1805701 attatattga tcccactttc cttgttcatt ctgtgtaaac accattcgca gcgcatcatg 1805761 atgacacgtt attgctttta acgtttttcg cagtgcgtct tcttgtacag aggtgcttcg 1805821 atgcagcatt acggactgat taaaatggtg tttttctttt atatcttgag aaagaaacca 1805881 tttttgaaca ggcgaccatt gtacgtctcc ctcaaccgca gcttggctgg aacttgtatc 1805941 tgaatcacgg atataagctg ccaattcttg aatggtcgga tggctaaaca aatctttcac 1806001 tgccatttgc ttgcctatcc ggtgaagccg cgcagatacc tgtaacgctt tgattgaatc 1806061 tccgccaagt tcaaagaacg aatcagctgt tccgatcttt tctgccccca gtacttcttt 1806121 ccatatatct gccagtattt gttccatttt gctggatggc gggaggaatg gacgttcacc 1806181 ttcgtggttg tatacaggtt ttggaagtgc tccgcgatcc agcttgccgt ttggtgacaa 1806241 tggaagtgag tccagttttt caataaacgc agggtgcata aacaccggca gcttgttttg 1806301 taattctgag cgtacagcat ttgtgctcaa ccctggtttt gtcaccacat aagcgcttaa 1806361 ttcggtttgt cctgacgctg ttacatgagc aactactgcg gcgtctttta caccctttat 1806421 acaccggatg accgattcaa tttctttcgt ttctacacgg tatcctctga ttttgacttg 1806481 atcatcgatt cttccgagat attcgagtgt accgtcggcc atccatctgg cggcgtctcc 1806541 tgttcggtac attcgtgctt cgggtttaaa tggattctgc gtgaatgctc tctctgtcag 1806601 ttctggaaga ttaacgtacc ctcttgcaag ccctgttcct gctatacaaa gctctcccgc 1806661 aacaccgatt ggctgaagct gatgattgct atttaaaatc agcacttgag ttccgtcaat 1806721 cggctggccg atgcttacgt atgcctgctt ttccatatgt ctcatgacgg tagtcgccac 1806781 gctgttttct gtcggtccat attcgttggc gagttcggta tgcggacata tagctaagct 1806841 gcgggcgatc aattcgcggt cagccgcttc tcccgccagt gtgacgactc taagcgtctt 1806901 tacatcttcc ggctgcacta cgtccaaaag cgctcgatat aaaacaggca caataatcat 1806961 atgtgtaatc cgttgacgag acagctgatg cttaatggcc agaatatcct tcgcttcctc 1807021 ttcatgaagc aaaacggctt ttgcacctga caaaagcggt gtaaacatac tagttataaa 1807081 gccgtcaaat gagaaagaaa agagctgcag aatggtatct gtctcgttga atgcataagc 1807141 gtttcgccgc cactgaagag tgttagcaat ccctttatgc tcgaccatta ccccttttgg 1807201 acggcccgtc gttcctgaag tataaatgat ataagccaaa tgatgggcag acgacatttg 1807261 cggcagcggc gatttgtcgt cttcctctac gctttctatc gtcaagatct ctccttcaaa 1807321 gtcagcaagt actcccagat ccgcttcatt tattgtcatc agcagtttcg ttccgctgtc 1807381 gctgaggata tagcgtttcc gttctttcgg gtattcagga tcaatgggaa cgtaacagcc 1807441 tccggctttc cacacaccaa gtatggatgc tatcatactg aacgaacgat gcatcatgat 1807501 gcctactggt gtgtccggct taacacctcg gctgcgcaat gcacgtgcga ttccattgga 1807561 ccactcgtca agctcctgat aagtgagtgt tttgtctccg ctgacaagtg cagaagcttt 1807621 tggtgttcgt gcagcttgct gctcaaacaa ttgactgatt gtttgaactc cgtattgatt 1807681 cgcttgcccg gtgttaaact cattaagcag ctggtgccgc tcttcttggg tcaggatgtc 1807741 gatatggttg agtgtcacct tcgggttttt gccgatgatg ctaagtacat ttgttaaatg 1807801 cgatgcccag cgttcaatgg tggttttctc gaacaatgcg gttgaatatt caaaaaggaa 1807861 atgaatgttt ccgtcgccct cagatgcctg tagtgtcaaa tcgaatttag aaacgagatg 1807921 agaaacttgt gccggcttca tttgcaaatc atgaagatgc aatggctcgt aatcattatt 1807981 ttgaacaact aacatcgcat caaacactgg gttccggctc atatctcgtg tcaattcaag 1808041 cttatcgaca agctcttcga acgggtaatt ctggtgctca aaggcttcca atgctgtctc 1808101 acgcacttcc tgcaaatact gtacgaatgg cttcccgccc tccgggcgcg tccgaagcgc 1808161 cagcgtgttc acaaacatgc cgagtatcgg ctcaagatcc ttgtgcggcc ggccggcgat 1808221 tggcgagccg acgatgatat cttcctgtcc gcttaagcgt gacaagaacg cggtgtaagc 1808281 cgcaaggagc accatgtaca gtgtgcttcc gttttctcgt gccagcttgt gaaggcctga 1808341 tgcaacctct ggttccagcg taaatgagac cttgtcaccc gcgaagcttc gcaccggcgg 1808401 gcgggcatga tcagcgggga gatccagcac aggcagctcg ccctcgagct gcttcagcca 1808461 gtacgcctcc tgcattttgt acgcgtctcc tgttttgaat ccttcttgcc atacggcata 1808521 atctttatat tgaatgcgca gcgccggaag cttccgatta ttgtacagct cgccgaattc 1808581 ttgaatcaga atgttgacgg aaacaccgtc tgaaatgatg tgatgcatat caaccagcaa 1808641 taggtgccgc tcatctgata cctttacgat ttgggcacgg aacagcggcg cttggctgag 1808701 atcaaacggt ttgataaatg cggctgcggc ctcctgttcg gttcgtgcgc cgagaactgt 1808761 agtctgtaac gtaaacggca cctcgtcatg gatgcgctgc accggatcgc ctccttcgtc 1808821 ctgttcgaag gaggttcgaa gcgactcgtg gcgcttgatc agctcttgga aagctctgtc 1808881 catcctttca gggttgagct tcccttcgag ctctaacaca gccggcatat tgtagcctgt 1808941 ccctccgtcc tccagctgct gaaggacata aatccgcttt tgggcagagg aaaccggata 1809001 ggtttcctgt ttttcagcgg gcttaatcgc ttcatatgga ctgtccgttc cttcacggat 1809061 aacggtagcc agtccttcta ccgtcggatg ggcaaacaca tcttttagcg gcacctgtac 1809121 atcgaattct ttggtgatcc gtgagacaag cgccgttgct tttaaggaat gtcccccgcg 1809181 gtcaaaaaag ttgtcgtgaa tcccgacagg gccatttttc agcacgtcct cccacagctg 1809241 agaaagcttc atctcagtca cgtttctcgg cgctgtgtag gtctccgcat ctgccgctcc 1809301 gccaggagct ggcagggcgt ttcggtcgag ctttccgctt ggcgtaaccg gccactgttc 1809361 catctctatc atataggctg ggaccatgta gcccggcaac agtctctcaa gctgcgctcg 1809421 gacttcgttt ctttggagcc cttctacata agcgcataat tccggctccc cgctgtctgt 1809481 ccgtacggta acggccgcct ctcttacacc ttctatactt cttagtgccg cttcaatttc 1809541 tcccggctca atccggtagc cgcggatttt cacctgatca tccgtgcgcc cgaggaattc 1809601 aacattcccg tcagggagcc agcgcgccac atccccggtt ttgtacatgc gttcacccgg 1809661 gtaaaacggg tcttcaagaa aacgctcctc cgttaatgcc ggccgattca aataacctct 1809721 ggcaacaccc gctccggcta tgtacagttc gccgatacat ccaacaggca gcatccgctg 1809781 attctgattc aggagatata atctgacatg atgaacaggt tttccaattg ggatccgttc 1809841 aagtttttca tgcggcggac aatcaaagaa tgcagcttct acggttgctt ccgttggccc 1809901 ataggaattg gttattgaaa catttggaag caactcgtaa aatcgggaga caagatgggt 1809961 ccccagctgt tctcccccag aaaacactcg cttgagtctg tttgtcttaa tcggtacaga 1810021 gcgatatttt atatgttcta aaaatgcatg gagcattgaa ggcacaaaat gcatagctgt 1810081 gatcttttgt tcttctatgg ccttcgcgat cacttcaggt tctttttcgc ctccctgagg 1810141 aagcagataa acagaagctc cggcataagg ccaccaaaac agctcccata ttgaagcatc 1810201 gaatgaatat gatgttttgt gcataatcat atctgaatgc tttagctgat agcgggactg 1810261 tagggaattc aaaaaattca ccgctgatcg atgttcaatt tcaacaccct taggcatccc 1810321 ggtagagccg gatgtataga tgacataggc taaagattgc gggagaacat ccacattcgg 1810381 attggacaaa cgatgtgcca gtccgctatt tgtctgattg agatagacaa tctctcctgt 1810441 aaattccgga acatgaaggc cggcagactg aagcaggaga atgtttgtac cgctgtcctc 1810501 cagcagaaag ctgattcgtt cttccggata atccgggtcg atgggcagat aagcgccgcc 1810561 agctttaaga atgccataaa tgccaagcag catttcaggt gaacgctttc ctataatggc 1810621 aacagtcgtt tcgggtttta ccccccgtcc gatcagctcc caggcgatac ggttagcctg 1810681 ttcgttcaat tctttatagg tcatcactcc atcttcgaag ataacggccg cctgatcagg 1810741 cgttttttct gcctgctgtt cgagtgcata gtggagcgtt tgattcattg aatagcccgt 1810801 ctcctcaaac agatggcatg attcaatgaa atctcgctct tcttcttttg ttaagattgg 1810861 aatattgtcc aattctgttt caggactggc agctgtatgt tccacaagcg tggtgaaaag 1810921 gctggcccac ctttggatgg tttctttctc aaacaaagct gtactgtatt caaactgaca 1810981 gaaaagctcg gaatcatgct ctgtaacgta tagggaaata tcaaattttg atattgggtg 1811041 ctccaagtcg ttccactgaa gctgtacatc attcattttt agcttttgct gttccatatt 1811101 ctgaaggact agcgttgtgt caaacaaagg attccggctc atttcccgct gcacaccgag 1811161 tttgtccaca agctcttcaa acgggtaatc ctgatgctca tacgcttcta gtgccgtctg 1811221 tctgacttct ttcagaaatt cctcaaatgt cttattaccc gccgggcgtg tgcggagagc 1811281 caatgtattg acgaacatcc caagaacagc ttcaaggtcg gcatggggcc gtccggcgat 1811341 aggtgaacca atcacgatat catcctgacc gcttaaccga gacaaaaagg ctgaatacaa 1811401 agcgagaagc gtcatataaa gcgtgcttct gtttttatgg gcgagccgct ttatgcgggc 1811461 cgtgatctct ttgtccaatt gaaaggttac ttttccgcct atgaattgcc gttctgccgg 1811521 acgtcgttta tctgttggaa gctccagtat aggaaggtcc ccgctaaact gctgctgcca 1811581 gtaagtctcc tgcttttggt acgagtctcc ctttttaaat ttctgctgcc atacggcgta 1811641 atctttatat tggatccgca atggcttaag ctgccggttt gcataaagat cggtaaattc 1811701 tcggattagg agctgaacgg atacgccatc tgaaatgata tggtgcatat ccaccagcaa 1811761 tacatgcttc tcgtttgaca cttctataag gcctgctcta aataatggcg cctggctgag 1811821 atcaaaggga cggacaaatc cctcgatagt ggtctcttta cttaacgtaa acggcacttc 1811881 ggtgtggata cgctgaaccg gctcgtcatc agctccggat acaaaggaag ttcgaagcgg 1811941 ctcatgccgg ctgatcagtt ctttacatac agcagacagt ttggcgacat ccagtgcacc 1812001 ttccagttct aagaccgcag gcatgttata ggcgacaccc tcatcaagct gttgaagcac 1812061 atagattcgt ttttgggccg aagatacagg atatgtatcc cttttttctg ctggttcaat 1812121 tgctgcatac agattttgtt ctgcctctcg aataattaaa gctaatcctt caacagtcgg 1812181 atgagcaaag atgtccttaa gtgaaacttg cacatggaat tcctttgcga tccgtgacat 1812241 aagcactgtt gcttttaacg agtgaccgcc attgtcaaaa aagttgtctt ggatgcctat 1812301 atgcccattc tttagcacat cttcaaatag ttgcgaaagc tttgcctcta acagatttcg 1812361 aggggcagta tatgggtttc cgctgattga agcatctggc tccggaagtg ctgcgcgatc 1812421 tacttttccg tttggggtaa gaggtatgct gtcaacccat atccatttcg ccggaatcat 1812481 gtattctggg agctcactag ccatataact gcgtaaatct attgtgttca gcttttgtac 1812541 actgcaatag taagcgcata attcatgttc accgttttga tcttgccaga tgagaatggc 1812601 agcctcacta atgtccggat gattcattag cgtgacttcg atttcttgcg gctcaattcg 1812661 ataacctctg attttcactt gattgtctgc ccgtccgata tattcgatgt tgccgtcttc 1812721 aagccgtctg gccaaatcac ctgtccggta catgatcaca tcaggcttga atggatcgga 1812781 tgaaaatttg tcgcttgtca gtttatcgtg attgacatat cctctggcaa cacttgcgcc 1812841 ggaaatatag agttcgcctg gtacgccgca tggctgaagc tgtttttgat gattcaaaat 1812901 atatagatca gtacagccta tcggtttacc gattggcgga agctcaggaa tagggtctcc 1812961 aggatgaatg gtatacgtag ataccacatg agtttctgaa ggtccgtaat gattgtgcag 1813021 gtgtatgccg cgtttacgca acacatcttg gaaaaggtct gaaatcatta attgttcccc 1813081 ggctgcgatc aggtgtttga cgccatcagg aaacgagttc gcaagttctc gctcgctgaa 1813141 aatcattttg ataaaagcag ttgggagaaa cacaatattc gtctgatgct tgtttataaa 1813201 tgcaaacagc tgaggcacat ctctttttat ggcttctggc acgatgtgga gtgtgccgcc 1813261 tttcagaagc gcagaaaata tttcttgata gcagacgtcg aaggaaggcg tcgcaaattg 1813321 cagaacatct gcttcaaagt caatgccgga gtgagtatat tcgaacttca gcaagttagc 1813381 catgtttcga tgctcaaatt gaacaccctt tggtttacct gttgtgcctg atgtataaat 1813441 catatacagc agatcgtcag cattgttgac tgactttatg ttactgccgt ctactttgct 1813501 ttcgatatct tctggatgag tgataatgta attgtcttct aacgatgagg gaagatgcgc 1813561 ttgtgaaaca acatgcgaac agccgcaatc atgcagaata taacggattc tgtcagcagg 1813621 gtaatgcgga tcaaccggaa caatggcgcc gcctgctttc aagataccaa gaacacctgt 1813681 gataaacgcc gctgagcgtt ccatcataat cgcaacgggt tcctgtctca caacgccttt 1813741 cattcgtaaa tgccgtgcca atctgttagc cgctttattc agttctctgt atgttaatga 1813801 gcaggcttga tcaattacag catgagcatc tggtgtcttt tccgcttgct tttcaaacat 1813861 ggcatggatg gtttcgtaaa ctggtgtttg atctgtgatt tctccaatca gctgccgctt 1813921 ttcagtatct gtcgtgatat cgatttcttc aggtggaaga ttcggattat ttaagatttg 1813981 tgatacagca ttcagaagat gctctttgac agagagcaca aaagaccgat cgtgctgctc 1814041 cgcatcatag ttcattttga tatgaatttc ttcccctggc gccaccataa gataaaagct 1814101 gtagttggtt tcatctgcga cagtgaaatt atgaatctga aaaagatcag aagcatgttc 1814161 ctgtttgttc agcatttgaa tctcttgctg caccggatag ttttcaaata cgagaatatg 1814221 atcaatcagc ccttgcttaa cagctgagcg ggattgaatc tcatataaag ggtggtagct 1814281 gtacgcttca gcggcaagac ggtctttttg catatctttt ataagttgaa gaaaaggcgt 1814341 ttttgccccc tgcacccgaa ccggcatcgt attaatgaaa agacctacca tatgttcaat 1814401 gccttcgatt tctgcgggtc ttcctgaaat gacagaaccg aatacggcgt catcgttatt 1814461 attatatttt tgcagcagaa tgccccaaat ggtatgaaaa atcgtactga gtgtcacttc 1814521 ttctctagca gcaagctctg aaagcctgct gctttcttcc ttagagaatg aaaatgtaac 1814581 gtgttcctgc ctgctttttc cctttgtttt tttctgcttc gggagcacgg tttgctgttc 1814641 gtggccggaa agataatgat cccaataaga aaccgcctgc tctttgtctt gctccatcag 1814701 ccatttgata tactttccgt atggctggac cggctccaat gttattgggg atgcatttac 1814761 ataagatgcg taaatatgca gaaactcctt tagcacaatg ctgaggcacc aaccgtccat 1814821 catgatatga tgaaaggtcc aaatgcaaga gtactggctc tctcctgttt gaatcagagc 1814881 gatgcgcatg agcacatcct tttgcaaatg aaacccccgg tcccggtcct tttctttcca 1814941 ttgctcgata aactgtgatt gctccgcctc gtttaaatga gtaatgtctt cttccagtac 1815001 gatgacattt cgttctctca gaacaacctg ctggggggag gaaacatttt ggctgataaa 1815061 aatcgttctg aaaatatcat gtctttctac aagagcgttg atgctgtttt gaaaaaactg 1815121 cgggttgact tttccttcta ttgtaaaaga agcttgctca acatacgcct gtgaatcttt 1815181 ttgcaggagg gaatggaaaa gcatcccttc ctgcatgtaa gacagcggat aaatatcctg 1815241 aattgaattc gcttttgtca tgttcatgtc tcctgtcacg attttctaca attcttccac 1815301 caagctggat atgctgtcca agtcctctgc cgttaatgat tgactgctga aatcgctcag 1815361 tgtcttttct gctttctgtt gaccggcgca gtgtttcata atgtccagca aaaagtgttc 1815421 aatcctgtta ataagctgtt ccattgtgtt tctgtgaaag cgggctggcg gataactaag 1815481 attgaaatgg agctttttgt ctgctgccat tgcactcatc tcgatgattt gctcgcgctt 1815541 ccatgtatga gtgatatcct ttccgctacc aaggcttgat gggcggaagg tgtcctgtct 1815601 ttcgatgtcg ttgaactggc ccaaatagtt aaagctgatt tcaggtgttt ttgaaaacgt 1815661 aatgctttta ttttcagggt gtgtaaggta tttcagcata ccgtaaccta cccctttgtt 1815721 tggtatccgg cccagtgtat ctttaacggt ttttactgag gttccgagct catccctatg 1815781 attttcaaag cttatgaggg ccgggtacat ggatgtaaac cagccgaccg tcctgcttat 1815841 atctaactct ggcagaatgt gttctctccc gtgtccttcc atagcgatac ggagcttgct 1815901 tcctcctgtc cattcacaaa tcgccaagga tgctgcggtt aacagaatat cttgtgtatc 1815961 tgtgccatag gcgtgattga cgttttgcag caagacggcg gtgtctgctt cagtcagtga 1816021 aaagcttaat gagtcccttt tgctgaagtc gatgttcaca tgatgcggta tttcataggg 1816081 cagttctgcg gcttgctgtt cttctacact tcgccaatac gcctcttcgc gaatcagctt 1816141 actgctttgg gcatattcct gtatgcgtct tgcgtattcc tggtaggaat ccgttttagg 1816201 cggaagctgg atcgtctggc ctgcagcagc ttgttgatat ccggctgaca aatcctccag 1816261 caaaatccgc catgagacac catcaacgac aaggtgatgg atcgcaagga acaagtaatc 1816321 tccggtcagt gttttaaaca aagcggcgtg caacaatggt ccttcctgca aattgatgct 1816381 ttgctgaaga tcggcaactt cttgtttgat tttcgtctcc cagccgcttt ctgactgtga 1816441 aagatcagag attcttaagc tgtatagctg tgactcatga atgccttggt tgatttgaat 1816501 ccatcgcctg tcatcgttgc gataaaccat ccgaagcgca tcatgatgct ccgccagttt 1816561 tttcaaggct ggtctaaggg cgttttcaga caaacgtcca gaatggaata gcatgacaga 1816621 ctgattgaaa tggtgtcttt cttcaatatc ttgtgaaaaa aaccattgct gaacaggcgt 1816681 ccaaggaacg tcaccctgaa tgggtccttg ctctatgatt ctctctgact tacggataaa 1816741 tggtgataag tcctttatct ttggatgacg gaataaatca cttacctgca agcttagtcc 1816801 atagcgccca aggcgtgcag aaacttgaag ggctttgatt gaatctccgc ccaattcaaa 1816861 aaacgaatcc tctattccga tcctctggat gcctagaacc tcctgccaga tcaatgccag 1816921 ctgctcttca agttcgttgc gtggcgggat gtatgtttgt ttagatgcga catctggttc 1816981 aggcagtgct ttccggttca atttgccgtt tgatgtgagc ggaagagtct ccatttcaat 1817041 gatatacgcc gggatcatat agtttggcag cgaacgcgcg agaagagaac gcacttgttc 1817101 agcattcgtg cctgctttta cgctgatata gccaaacagc tctttgctcc cggtctgggc 1817161 tgtacgtgct aacactgcgg cttctttgac cccgtctatt tgacgaagtg ctgtttcgat 1817221 ttcacccagc tccacccgat agcctctgac ttttacttga tcatcaatac ggccaacgta 1817281 ctcaattgtg ccatcggaaa gccagcgcgc cagatcacct gtgcgataca gtcgatcgcc 1817341 aggtgcaaat ggatgtggga caaatttctc tttcgttaaa tcaggacggc ccaaatatcc 1817401 tctggcgacg ccatctccgc cgacacaaag ttcaccgaca gctccgaccg gctgcagcac 1817461 tccccattga tttaagataa aagcggtgga attaccaacc ggccgcccga tcggaatgga 1817521 aagttcatat gttttttgaa tgtgaaggca tgtcgaaaaa gttgtatttt cggtagggcc 1817581 atatccattc catatagata cttcagggca gacatttctg attcgattga cgtggctcgg 1817641 cgacaaagct tctccgccaa taatcaaatg tttcagctgt gaaaatgttt gttcattttg 1817701 ctctgtcaaa tgattgaata gagaagatgt cagccaaatc gttgtgattc cttgatgttc 1817761 tatgtacctc ttaagctgat gggaatcgag aaatgtttgt tgatcggaca gatgcaaagc 1817821 ggcaccattt agcagcggtc cgaaaatttc aaatgaccca acgtcgaaac cgattgatga 1817881 tgtcatcaga aggcggtctt caggtgtaaa tgtaatataa ttgctgtttt taacaagacg 1817941 aattacactt cgctgctcaa tcatgacacc ctttggttta ccggttgatc cagaggtata 1818001 aatgatatat gcaagtgaat ggggccctgc tgaagattca acgttcttcg cctctccttg 1818061 cttttgaata tcttcgatta tgatttgttc acattcaatg cctaatagcc gtttttctgt 1818121 tttttcagat tgaaggagta atgctgccct gctgtcagac agcatataag ctatgcgttc 1818181 aacaggcaga ttagaatcga taggcagata ggctcccccg gcttttagaa tgcccagcat 1818241 tcctgcaatg agttctggtg ttctgcctgt caacaaggct acaacactat caggccctac 1818301 gccctttatc tgtagaactg aggcaatttg atttgcccag ctgttcaggt cctcgtaagt 1818361 gaatacttgg gtgtcgctga caattgctac agcattaggt gtttgttctg cctgcatttc 1818421 aaagagtctg ctgatggttt catttcttgg ataatctatt tttgtacgat tgagctcgtg 1818481 gataaggtaa tgggcctcat cctcattcag gatatttatt gttccgagag cggctttgtt 1818541 gtctttgatg atggagagta acatattgtt gaagtattga agccactttt ctatcgtttt 1818601 tttcttatat aagtcagtac taaactccat ttggaacgtc agcaaaccgc ggggctgttc 1818661 ctgggcatat agggttaaat caaatttgga cgtttgatgc ccattgtttg ctgcaggttt 1818721 gagacaaagt tcatccagct ccaacgattc ctgatccata ttttgaagaa caaacattac 1818781 gtcaaacagc ggatttctgc tcatatctcg tgtcaattca agcttatcaa caagctcttc 1818841 gaacgggtaa tcttggtgct caaaggcttc cattgctgtc tcgcgcactt cctgcaagta 1818901 ctgtacaaac ggcttcccgc cctccgggcg cgtccgaagc gccagcgtgt tcacaaacat 1818961 gccgagtatc ggctcaagat ccttgtgcgg ccggccggca attggcgagc cgacgatgat 1819021 atcttcctgt ccgcttaagc gtgacaagaa cgcggtgtaa gctgcaagga gcaccatgta 1819081 cagtgtgctt ccgttttctc gtgccagctt gtaaaggcct gatgtaacct cttgatccag 1819141 cgtaaatgag accttgtcac ccgcgaagct tcgcatcggc gggcgggcat gatcagccgg 1819201 aagatccagc acaggcagct cgccctcgag ctgcttcagc cagtacgccc cctgcgtttt 1819261 gtacgcgtct cctgttttga atccttcttg ccatacggca taatctttat attgaatgcg 1819321 cagtgccgga agcttccgat tattgtacag ttcgccgaat tcccgaatca gaatgttgac 1819381 ggaaacaccg tctgaaatga tgtgatgcat atcaaccagc aacaggtgcc gctcatctga 1819441 tacctttacg atttgggcac ggaacagcgg cgcttggctg agatcaaacg gtttgataaa 1819501 tgcggctgcg gcctcctctt cggttcgtgc gccgagaact gtagtctgta acgtaaacgg 1819561 cacctcgtca tggatgcgct gcaccgggtc gcctcctgcg tcctgttcga aggcggtccg 1819621 aagcgactcg tggcgcttga tcagctcttt gaaagctctg tccatccttt caaggttgag 1819681 cttcccttcg agctctaaca cagccggcat attgtagcct gtccctccgt cctccagctg 1819741 ctgaaggaca taaatccgct tttgggcaga ggaaaccgga taggtttcct gtttttcagc 1819801 gggcttaatc gcttcatatg gactgtccgt tccttcacgg ataacggtag ccagtccttc 1819861 taccgtcgga tgggcaaaca catcttttag cggcacctgt acatcgaatt ctttggcgat 1819921 ccgtgagaca agcgccgttg cttttaagga atgtcccccg cggtcaaaaa agttgtcgtg 1819981 aatcccgaca gggccatttt tcagcacgtc ctcccacagc tgagaaagct tcatctcagt 1820041 cacgtttctc ggcgccgtgt aggtctccgc atctgccgct ccgccaggag ctggcagggc 1820101 gtttcggtcg agctttccgc ttggtgtaac cggccactgt tccatttcta tcatataggc 1820161 tgggaccatg tagcccggca acagtctctg aagctgtgca cgcacttcgt ttctttggag 1820221 cccttctaca taagcgcata attccggctc gccgctgtct gtccgtacgg taacggccgc 1820281 ctcccttacg ccttctatgc ttcttagtgc cgcttcaatc tctcccggct caatccggta 1820341 gccgcggatt ttcacctgat catccgtgcg cccgaggaat tcaacattcc cgtcagggag 1820401 ccagcgcgcc acatccccgg ttttgtacat gcgttccccc aggtaaaacg ggtcttcaag 1820461 aaaacgctcc tccgttaatg ccggccgatt caaataacct ctggcaacac ccgctccggc 1820521 aatgtatagt tcgccggcga caccggaagg ctgtacggct aaatgcggat ctaaaacata 1820581 caaacgcgca ccaggtacgg gcttcccaat cggaatccgc aaacggtctc tgtcccgttc 1820641 tggatctaac acgtaaaatg ccgcgtctac cgtggcttct gtcggcccgt agccatggat 1820701 taatgatacc tgcggcaata cagaagcaaa acgggctgcc gtacgcggcg caagcggttc 1820761 acctccggcg aatacacgct ttaggcttgt cctgtcactc agcctttcga tttccgcttg 1820821 atcgagaaag ctgttcagca tagccggaat aaaatgagcc gttgtcacgt tttcctgatg 1820881 aatggcttgt acgatcaatg cggagtcttt ttcccagccg ggcggaagca gatacgccga 1820941 agcaccggaa agagcccacc aaaacagctg ccacacagac gcatcaaagg aaaaagaggt 1821001 tttcaccatg acaatgtcat cttccgaaag ccgaaactgg tgctgcatgc cggtcagaaa 1821061 ggaaacagcc tggcggtgct caacggccac tcctttcggc tgcccggtag agcccgatgt 1821121 atagatgaca taggcgagag atccgtcgct aacagaagca gacacatgac gttttacttc 1821181 ttcacactca agagatgtca tgtccacttc aagcgtttcg ccagaaaagt ttggtgcgga 1821241 gcatcccggc tgtgtcagca agagcgatgc cccgctgtct ttcagcatgt agctcagccg 1821301 ctcctttgga tacgcaggat caagcggcaa atacgcccct ccggccttca atacagcaag 1821361 gacagcgatc agcatgtcag gtgagcgttc agacaggaca ccgacgatac tttcgtttgt 1821421 gacgccgcgt gccgcaaggt gcgcagccag ccggctggcg tacatatcaa gctcagcgta 1821481 tgtcagcgaa ccgcctgaaa agcgaatggc cagccgctcc ggtgtgactg ccgcctgtcg 1821541 ttcaaacagc ccatgcaggg ttggggcttc aggtgaaaca gatactgtcc tgttattttg 1821601 agaaacgatt ttccgtgttt tgtcctcatc tagcaacgtc atctttgaca caggaagaga 1821661 tggatcagag atgacgtcag agaccatgtg cagcaaataa tcttttattt cggacatcat 1821721 gcttggttga taagcgctgg tctgaaaatg aatccgaacg tacaaggtac ggcctgggat 1821781 cactttgaca ctgcaactat aattggtcac ctcttccatc tcaaaatctt tgacggagaa 1821841 atcaaatgac cccgcttgat tcagctcttc gatctcttgc tgggtaggtg tattttcaaa 1821901 gacgataata tgatcgatca actcttgctt tagagcactc tgcgcctgaa tatcatacaa 1821961 gggaaagtaa ctataggctt ctgcctcatt catgtccttt tgcattctcc tgactaggtc 1822021 agaaaaagac agagaatcac tttgggctcg aataggaatg gtattgataa aaagcccgac 1822081 catgttttcc acatctttta gctcagaagg tctgcctgat ataactgaac cgaacacagc 1822141 atcgctgctg cgattgacct tttgaagcat aatcccccat aaagcttgga aaacagtgtt 1822201 tagtgtcgca ccagaagctg ctgcgatttt ctgtaattcg gcggtttctt tttcgggaat 1822261 ggcaaacgtg atctgctgta gtgtcccatt cggaatttga tctgttcttt tcggcagggg 1822321 tgtagatttt tcgaaatgct gaagcctctt tttccagtac tcagctgctt cttcacgatc 1822381 ttgctgcatc agccatttaa tatacgtccc gtacggctgt acgggaggca aatcaggaag 1822441 ctggccttta cccagcgctt gataaatatg gagaaagtct ttaatgacga tgcctaaaca 1822501 ccagccatcc attaaaatat gatggtggct ccagatacag acataatgat caggcgccca 1822561 ttttaaaata gatattctca tcagtacatc cgtttggaga tcaaagcctt tggatttgtc 1822621 ctgctctttg aatgcctcgg tacaatgttc tttatccctt tcattgagat gggaaatatc 1822681 ttcaatatga atagggcaat gacgttgctt gagcacgact tgacgaggtt tggctacatt 1822741 tttatagatg aatgctgttc gaaagatatc gtacctgtca aaaacagcat ccatactttt 1822801 ttggaaacgc tccaagtcaa gctgtccatg gatcgtaaaa gaagcctgtt caaaataagc 1822861 tctcgactgt tcatcataca gtgagtgaaa aagcatccct tcctgcataa atgacaaagg 1822921 gtatatatcc tgtatttcag gttgctgcgg catcagtgaa tctcctctcc tatagtttgt 1822981 tgacggctcc catgatctca ctcaattcat caagcgttaa gtcttcatca gtgaaatcag 1823041 atgcgctcca ctcttggttt tctttgccgg tacaatgctc aatgatgttt tccagagtct 1823101 gtttaaaatg cctggaaaat gtttggattg ttttttcctc aaattgaaac ctgttataga 1823161 tgatgtgcat gttcaggcac cccgaagaaa cggcgccgct gatatccagt gcataaggac 1823221 gctcccagtt cgggctgatc tcatttcctg gcttgatgtc agacacctca aaggcatttg 1823281 attgaatatc ctgatcaaac tggcctaaat aattaaagct gatttctggg ctgtttttct 1823341 gagagcccca tcttttgctg atatatttca gcacgccgta gcccgcgcct ttatgcggta 1823401 tacggtgcag catatctttt gtctgtttaa taaggtggcc cagccgctct tctttgtcct 1823461 tatgatcgga atctctcata tcaagccaca caggataaat ggaggtgaac cagccaacag 1823521 ttctgctaat atcgatgtcc tcaagatatg attcccttcc atggccctcc atgctgattt 1823581 taaattggtt atttcccgtc catttctgca aagcaagacc taaagctgtc agaaggatat 1823641 cattcatctc cgtgctgtaa gctttatgtg cagccgttaa tagtaattct gtgtgatggc 1823701 gagatagctc aaaatcaatc acttctgtat ctttgaatgt gttagatgct gcgtcattgt 1823761 cttttggaat aggctggatg tgacggttct cgcactcatc ccagtacgct gcttcgcgct 1823821 gcacctggcg gcttatagag tagtcagcta ttctttgtga atacgttaaa tatgaatctg 1823881 ttttttgcgg cagtttaata gattctcctg agactgcctg tttgtaagct gttgaaaaat 1823941 cctcaaacaa aatgcgccaa gaaaccgcat caacaactaa gtgatgaatc gttagaaata 1824001 aatggtcacc attctcggtt ctaaacaatc cagcgtgaag taaggggccg gtttccaaac 1824061 gaatatgttc ttgcatccgg ctggctgctt cctcaatcgt gttccgggct tctgttaggc 1824121 tatcctttac atcaaacagt tcaagtgcat atagctcctc atctgaaaga tctatccctc 1824181 tgtttatctg cacttgcctg ccatcttcat gccggcatac gattctcagt gcatcatgat 1824241 gagtcacaag gctttttagt acttttctaa gcgcagcctc atcaaatcgt tcagcccggt 1824301 agatcataac ggattggtta aaatgatggc tttccagaga ttgcgagaaa aaccactgct 1824361 ggataggtgt ccaagtaatc tcgccttcga ccgggccttg gtcaatggcg cgtacgtctt 1824421 ttcgaacccg ggcggacagt tcaccaagag tctgatgttc aaacatctca cgtactgtcg 1824481 tttcaaatcc gcgctgcttc agtctggcac aaacctgcag cgctttaata gagtctccgc 1824541 caagcttaaa gaaattggcg cttacaccca gctcatctac attaagaagc tcttcccaaa 1824601 tttcagccat caccgtttca atctcatttc taggactgat atcatcagct gtataagctt 1824661 gtttttcagg ctctggcagg gctttctgat cgagctttcc attaacagtc accgggatgc 1824721 tgtcaatttg tatcatacgg gcaggcagca taaagtcagg caaggcgttt tttaggtaag 1824781 ttcggatgtc tgatatattc gcagcctgtt gatcttttat caccatatat gcatatatag 1824841 ctgtttgccc ttgctcgtct gctctggtaa tgacagccgc ctctttaatc attggatact 1824901 gaagaagtgc cgcttggatt tcgcctaact caatacggtg ccctctgact ttcacctgct 1824961 catcaatgcg gcctaagtat tccagctcgc catttgacag gcgcttagca agatctcctg 1825021 ttcggtataa tctgtctccc ggaagataag gattggatac aaaacggtca gcggtcagct 1825081 catctctgtt gagatatccc cgtgccacac cttcgccgcc tatatacagc tcccctggaa 1825141 ctccggtcgg ctgcaggttc atatgggcat ccatcacatg agcctgcaga gtagaaagag 1825201 gccggccgat attgctttta ttttttgcaa tgtctgctgc ggacaatttt ttgaatgtta 1825261 catggaccgt tgtttctgta ataccgtaca tattaatcaa atcagtatga ggatattttt 1825321 cattccagct ttgaagcaat ccgggctgta aggcttcgcc gccaaaaatc acatagcgga 1825381 tgtttaaatg atctgtatga ttttggtctt caagcatcaa gccgtaaaaa gcagtcgggg 1825441 tctgattgag tacagtgacg cgctcttttt ttaacaataa tcggaatgct tgggggtcac 1825501 gggctgtttc tttagagacc acgactaatg tacttccgtt caataacgca ccgaacatct 1825561 cccatacaga gaaatcaaag caataagaat gaaataacgt ccagacgtct tcatggttaa 1825621 attcaaaagg caggttttga tgcttcaaga gactgatcac attgcggtgc tcgacaatga 1825681 ctccctttgg ctgaccagtc gttccagatg tgtatatcac gtatgcgggc tgatccgtta 1825741 ctatttcttc aatgtttaca tcagccggaa ttgagttgtt ttcacattca tcgatataca 1825801 aaatatgccc ggtgtagtct gcaggtttgt ttagaccgcg ctctgtcagc agcagttttg 1825861 ctccgctgtc attgagcata aagctaatac gctccttggg atattcagga tcaatcggca 1825921 aataggcccc gccagctttt aaaatcgata aaacgccaat gatcatatca ggtgaccgat 1825981 cgagcatcag accgacgata tcgccagttc tgaccccttg tttgatcagc atagcagctg 1826041 cccgctcggc tttttcattc aggtctcgat acgtaagctg agaatggccg cacaccactg 1826101 cgatatgctc cggatactga gctacttgct tttcaaataa gcttactatg ttttcatttc 1826161 tcggataagc tgcatactgc cccatttttt caaggagtaa cctacgctct gcagcaggaa 1826221 gcaattgcat gttcgaaatt ctcatctcag tatccgccgt tacccctttt accaattcaa 1826281 taaaatagga tgcccactgc gtaatggttt cttcttcaaa aagagcagtg ctgtattcaa 1826341 aacggcagcg tattccactc agatgctcct cagcatgtaa tgttaaatcg aatttagata 1826401 tatcatgttt aggagtgaca gacgaaatcg acagaccagg cacttcgaac cggaaatctt 1826461 cactgctttg aagcacaagc atcgcatcga acagcgggtt gcgatttacc tctcgatttg 1826521 tatcgagctt atctgccagc tcctcaaaag gataatcctg atgctcgtaa gcggtcagag 1826581 ccaggtggcg aatgtcatgc aaataggagc tgaacgtttt gtggccctcg ggcttgctgc 1826641 gcatcgccaa tgtattgacg aacattccga tgacgcgctc cagatcagcg tgcggtcttc 1826701 cggcagcagg cgaaccgaca acaatatcct cttgcccgct tagcttagat aacaaaatag 1826761 aatagacagc cagaagaatc atatacaatg ttgttcccgt ttcagccatt aaacggtgca 1826821 gttcatcagc catgtcttta tcaatgttga cttcaattgt tccacccctg aaatcaggga 1826881 gacgcggcct tgttttatca agcggtaatt ctagtgtagg aagactcccg ccaagctgac 1826941 cgagccagta ggcctcctgt tttttgtata gctctttcgg gtgcttctct tgctgccaaa 1827001 cagcaaaatc cttataatgc aggtttaaag ctggcaactc ttttccgcaa tataagtcag 1827061 taaattcttg gacaagagtg ctcatcgaga caccgtcggc aataatatgg tgcatatcga 1827121 gcagcaaaaa gccgcgatta ttgcccattg taatgacaca tgctctaaaa agcggaccgg 1827181 atgatagata aaacggtttg ataaaggtct cgattgcaga ctcaagcatt tgttctgatt 1827241 ccatttcaag ctcttttaga tcaaaagcca tctctggata aatgatctgc acaggctcgt 1827301 ctctgtcaag cacaaaaaca gtccgtaatg cttcatgccg attcacaagt tctgtgagaa 1827361 cgcttctcaa ccgctggcga ttcagatttc cgcgtaattc aagtacagct ggcatgttgt 1827421 agcctgtgct gtcatctgcc agctgatgaa gagcatataa tcgtttttgc gagaaagaca 1827481 gcggatagac atctctttga tccgcaggtt caatctgtgt aaaagcgtgt tcttttaagc 1827541 tcatcaattt gaccgccatg ctttcaaccg tcggataaga aaacacctca ctgagcggca 1827601 gctcgacatt aagcttttta tgtattcttg ataccagtgc ggccgctttt aaggactgtc 1827661 cgcctaactg aaagaaatca tcacgaatgc cgatgtgctg tttattcagc acatcttccc 1827721 aaatatgtgc gagatcagct tcgattaagg ttcggggcgc catatatgtg acactcgtat 1827781 tgttttctgg ttcaggaagc gcaaacctgt caagcttgcc gctggatgtt aatggcatct 1827841 ggctgatgtt gataatactt gctgggatca tataggacgg caatgtcccg gcaagatgct 1827901 gatacaaatc tgggaggctg tttccctttt ccggaacgat ataagcaacg agctcctttt 1827961 cctcagcaga aacatcacgg gccagtaccg ctgcttcttt tacccccggt gcttgtcgaa 1828021 gaactgtttc aatctctctc agttcaatac gataacccct aattttcact tgatcatcaa 1828081 aacgtccaat atattcaatc gttccatcag gcaaaaagcg gcctgcatca cctgttcggt 1828141 ataaacgctc cccttcaagg aatggatgat cggagaatgc tttctgtgtc agctcttgct 1828201 gtttgtagta tcctctcgca agacccgcgc cggaaataca cagttcaccc gccgcgccga 1828261 tcggctgcat ttgatttccg tgcaaaacaa atacttttgt gtttctgatc gggtgtccga 1828321 tcgtgatcct ctctttttta ttcagatgcc gcaatattgt tgttgccaca ctgttttctg 1828381 tgggcccgta ttcatttgcc agttcagcag aaggacaaat tatttgattc aactcaagca 1828441 gatcaggcgt gaccgcttca cccgcaaatg tcacaatacg aagacttttt gcatcgtcag 1828501 cagtcatcac ttccaataac accctgtaca gggaaggaac aatgatcatg tggctgacct 1828561 tataacgggc tatttttcgc ttaagggcca gcacatcctt cgcttcgtca tctgttgtca 1828621 gcagtacgca cgcaccagat aaaagcgggg taaataagct cgttacacag ccgtcaaaca 1828681 cgtacgaaaa caaatggagg gatatatcct gttcggtcat gctatactct tcccgtctcc 1828741 attgcaatgt attggcaata ccgtgatgat caactaaaac ccctttaggg cgccccgtcg 1828801 ttcccgacgt atagatcaag taggctagat cacctggcgg catatttggc gcttctgttt 1828861 ggtaactttc tgtatgttct atcgttatcg tatttccttc ataggacgga gggatcaagg 1828921 aaataaggtc ttcttctatc agcaattgag ccgcttgact gtccttcaga agaaaagaaa 1828981 gacgttctgc tggaaaatgt ggatcaagcg gcatataagc gccgcctgct ttccaaatcc 1829041 caagcagagc tgcaggcatt tccattgacc ggcccatcat tacagcaacg atatccccag 1829101 atccaacgcc tttttctatc agggcgtgcg caatctgatt ggctcttact tgtaactggc 1829161 gataggtcca gcactcgttt cccattttca atgcagcagc ttcaggtgtt ttgtgagctt 1829221 gttcctcaaa caattggggt atcgttttgt tcacataagg acgctcagtt tcgttaaaca 1829281 attggataac ctgttgctcc tccggcggca cgatattgat gtcactgacg gcaacatcgg 1829341 gatttgtcaa aatgcaatcc agtgcttgct ttagatgccc ctgaatcctc agcatctcct 1829401 cccgctcgta aacgtctgcg ttgtagctga atttgatata aaatgattct cccggaacga 1829461 taacgatatt aaagtcgtaa ttggtttgtt ccgacattga aatgtcactc agcttcagag 1829521 cgccttcgtc attttcactc tccacgctta atgcctgatg aagctgtaca gggtaatttt 1829581 caaaaacaaa aatatgatcg atcaaccctt gcttcaatgg actatggttt tgaatctcat 1829641 aaagcggata atacccatgc tgttcagatg ataaaatatc ctcctgcacg gctttgacca 1829701 gcgaagaaaa tgttatgcct tccgcagatc ggattcgcac tggaacagta ttgataaaca 1829761 aaccgaccat tgattcaatc ccgtcaatcg ctgacgggcg tcccgaaatg acggagccaa 1829821 aaacggcatc atctgcagca ttatatcgat ggagcagcac gccccaaata ctcataaaca 1829881 gcgtgtttaa tgtcactccc cagttttggg cagcctctgt cagtttctca accatatccg 1829941 gcgctaatga aaagctgacc tggtcggctt tataattccc gtctgccgtg cggcgcttta 1830001 ttcggggaat agaagcagta ttgccgtact ccttcaaata ttcgctccag taggcagcag 1830061 tctcttcttg atcttgttct ccgagccatt caatataacg gctgtacggc accgtgctgc 1830121 caagctgtac aggtgagtta tttttgagcg aatcatacat gctgaaaaac tctttaagaa 1830181 taatgccgag acaccaccca tccatgatga tatggtgatg tgtccagaca catgtatatt 1830241 ggctgtctcc tctatcaaaa agggcaagac gcattaaagg atctttttgc aaatcaaatc 1830301 ctttttcccg atccttagtc ataaaagcat caatcagcgt ctgctgttct tgatcagcca 1830361 ggcgagaaat atcttctcta tatactgtca attcacggtt tgatagaact acctgctgcg 1830421 gacctgtaag atctggtact tctttaatga aaatcgttct gaaaatatca tatctagaaa 1830481 caagaaggtt taagctcttt tgaaacgagt cgacgcatag attccctgtg atcgtaaacg 1830541 aggtctgttc gatatatgct ttcgagctga aatccattag tgaatgaaac agcattcctt 1830601 cctgcatgtg cgataacgga taaatatctt gaatttgtgc cgattgtgcc atcaattcca 1830661 cacacctttt caaaagttaa agatctttca cgagatcttc gatgctagat aatgcagaca 1830721 acgttaattc tttattgctg aaatcgctca atgttttttc gcgtgctttt ttctgcgaac 1830781 aatgctcaat cgtctcgata agatgcctgt gaaaacgatc cataaagcac tcaattgagt 1830841 gtttgctgaa cacttgggtg tataccgctt ttacgtgaag ccgtccgtcc gtaatgagag 1830901 cattgatgtc cagctcatac tctcgttctc tctcacccgc tatttcgtaa cggggctggt 1830961 aatatgataa ttgaaacgtt tcaacttcct tctcttcgct aaattgaccg agataattaa 1831021 agctgacctc aggctcttta tgccgcagtt ctcctatgtg tgttaacaat ccgtatccag 1831081 ttcctttgtt cggtactctt ctcagcatat cttttgtcgt cttaattcgg tatgcgagct 1831141 gatcctcgaa aggctcggga atacccatgt ctagcagaat aggataaatg gaggtaaacc 1831201 atccaactgt ccttgaaata tcaatgtttg gcacatgccc ttctctaccg tgtccctcag 1831261 tgctgatcac gatttggtca tgcccagtcc attcagaaag cgccattcct aaagccgtaa 1831321 gcaaaagttc gttggcatca gtaccatagg cttgctgggt ttcaaacagc aatttttcag 1831381 tccagtcccc ggatagtaca aacgctgctg cgtcgctgtt catttggagt ttgtctggca 1831441 cattttctat gtccttagga agaaaagcag tgtgagcgtc taaaatcgtt tgccaatacg 1831501 ttttctctga aagcaattgt ttactttcag ctatttgggt aagaccatcg gcgtaggata 1831561 aataagaatc cgtttttggc ggtaattgga tttctttctt ttctaaagcc tgttgatatg 1831621 ctgcagctaa atcctcaagc agaattctcc aagaaacgcc atctatcaca agatgatgaa 1831681 gtgcaatcag caaatgatcc ccttctgccg ttttaaacaa acctgcttgc agtaagggcc 1831741 ctttttctac attcattttg ctttgaatga cggtttcctc agcggcaagt ttttcatcaa 1831801 gatgagccct ttccagcgat gcttttgtcc aatctgaaat ataaaggcca aacagttcat 1831861 gatccttgtg attgattccg cgattaaact gaatgacatg gccgttttgg tcacgttgga 1831921 aaatcatgcg aatggcatca tgatgctcgg ttattttacg cagcgctaga tgaagcgcgt 1831981 tagcattgaa tcctttttca ctgaaaagca tgacggactg gttgtaatga tagtgaaaag 1832041 catgtacctg tccgaaaaat cttcgctgaa tcggggtgag ttcagcttca ccttccgcag 1832101 gtccctggtc cgcttgagat gccaatggtg tgatatgtcc gcatagttcc tgaatcgttg 1832161 aataacggaa taagtcgcgt attgtcatgc tccagccttc agctgccaga cgtgctgcca 1832221 cttgtaatgc tttaattgag tctccgccaa gctcaaaaaa ggaatcgtga atgccgactc 1832281 gtgacatgct cagtacatct tcccatatat acgccatcgt tttttgtaag tcgttaactg 1832341 gtgcggtata tggacgcgat aacacattat ttggagccgg caaggcattt ctgtccagct 1832401 ttccgtttag ggtcagcggc atgtttacta aaggaatcag atatgcagga atcatatacg 1832461 ctggcagttc ctttgttaaa gcagcacgga gagcattcgt attgacgtct gaaggcacaa 1832521 tatatgctgc caaaccagcc tgtccatttt tatcatgctg aacggcaaca gcagcttctc 1832581 tgacaagccc cgtttgaagc agaacacttt caatttcttc tgtttcaatt ctgtatccat 1832641 ttatctttac ttgataatcc attcggccaa gaagccggat cgttccgttt ggaagccagc 1832701 atgctcgatc accggttctg tacagccttt ctccagagac aaatggattt tctgtaaatt 1832761 tcatttgcgt taagtcaggt ttatgatgat agcctttcgc aacacctgcc ccgccgatgc 1832821 acagctcgcc ggcaacaccg atcggctgaa tttgatcagt ctggctgagt acgtacatgt 1832881 gtacattcgg cagcgggctg ccgattggta cgttatctcc cgtacactct ccacccatac 1832941 tggtttcata gaaactcgaa tcaatggttg cctctgtgac accatagcta ttaatgatgc 1833001 gcatgctttg gccaaagcga tctgtcaatg ttttgaaatc ttgagctttc accatgtcgg 1833061 aaccaagaat cagtatgtct aagtcaggaa gcttgaactg gttacggtat acatactcca 1833121 tcaccgggat aatgagagcc ggtgtcgact ccatcaccgt gattctctga gatttaatga 1833181 ttttatatat ttcagcaggt tccagccgtg tttcatctgg gcaaacgatt agagtcccgc 1833241 cgttggtcaa tgttctcgcc aaatctcctg agaagacatc gaatgaaaag ctcgcgattt 1833301 gaagcagtct gacaggcttc cgatccagtt cataaatttg acgccaagca agagcagcat 1833361 gagtaaagtt ctgataggtg acaataacac ctttaggcgc acccgtcgtt cctgacgtat 1833421 aaatgatata taccggctct tcaggagcag gagataagtt aaggttgcag ttactttctt 1833481 caaaagagcc ctcatcgtca aggaagatgt gagacatctc agattcaggc gagttcgaaa 1833541 tcaaatgctt caactctctc tgtaaaagaa gaatatctgc cccgctatca cgaagaatgt 1833601 attcaatacg agcttttgga taatgtgcat cgattgggat atacactccg ccagctttca 1833661 tcactgccag aactccaaca attgcatcga tggaccgctt ggctaaaaca gccacagttg 1833721 gcttcggtcc ttttctgttt tgcaatgttc gtgccagacg attggctctt tcatttagaa 1833781 ggcgatagct aatctctgtt tcgttatcaa taacagctat atgttctgga ttttcttcag 1833841 ctttcgcttc aaatatgcga tgaaaaggaa tatctttttg agcaaattca acttgagttt 1833901 tgttaaattc aaagactatt ttttgttttt ctttatcact aagtatgttt atttgtgcaa 1833961 ggcttgtttc aggagttgaa agtgcctcat gcagaaattc gataaaatga tcagcccagc 1834021 gttcaatcgt agctttcagg aatacttctg tactaaattc catttcgcag caaatagatc 1834081 cacttatttc cgtagctatt aatgtgatat caaataagga aatgtgatgt gcgaaattgg 1834141 caggccggac ttttatttct ctcagatcta tgtcttgttt ttccacattt tgaaggataa 1834201 acatcgcatc aaacactggg ttccggctca tatctcgtgt caattcaagc ttatcgacaa 1834261 gctcttcgaa cgggtaatcc tggtgctcaa aggcttccaa tgctgtctca cgcacttcct 1834321 gcaaatactg tacgaatggc ttcccgccct ccgggcgcgt ccgaagcgcc agcgtgttca 1834381 caaacatgcc gagtatcggc tcaagatcct tgtgcggccg gccggcaatt ggcgagccga 1834441 cgatgatatc ttcctgtccg cttaagcgtg acaagaacgc ggtgtaagcc gcaagaagca 1834501 ccatgtacag tgtgcttccg ttttcacgtg ccagcttgtg aaggcctgat gcaacctctt 1834561 gatccagcgt aaatgagacc ttgtcacccg cgaagcttcg caccggcggg cgggcatgat 1834621 cagccggaag atccagcaca ggcagctcgc cctcgagctg cttcagccag tacgcctctt 1834681 gcgttttgta cgcgtctcct gttttgaatc cttctcgcca tacggcataa tctttatatt 1834741 gaatgcgcag tgccggaaga ttccgattat tgtacagctc gccgaattcc cgaatcagaa 1834801 tgttgacgga aacaccgtct gaaatgatgt gatgcatatc aaccagcaac aggtgccgct 1834861 catctgatat ctttacgatt tgggcacgga acagcggcgc ttggctgaga tcaaacggtt 1834921 tgataaatgc ggctgcggcc tcctgttcgg ttcgttcgcc gagaactgta gtctgtaacg 1834981 taaacggcac ctcgtcatgg atgcgctgca ccggatcgcc tcctgcgtcc tgttcgaagg 1835041 aggtccgaag cgactcgtgg cgcttgatca gctctttgaa agctctctcc atcctttcag 1835101 ggttgagctt cccttcgagc tctaacacag ccggcatatt gtagcctgtc cctccgtcct 1835161 ccagctgctg aaggacataa atccgctttt gggcagagga aaccggatag gtttcctgtt 1835221 tttcagcggg cttaatcgct tcatatggac tgtccgttcc ttcacggata acggtagcca 1835281 gtccttctac tgtcggatgg gcaaacacat cttttagcgg cacctgtaca tcgaattctt 1835341 tggcgatccg tgagacaagc gccgttgctt ttaaggaatg tcccccgcgg tcaaaaaagt 1835401 tgtcgtgaat cccgacaggg ccatttttca gcacgtcctc ccacagctga gaaagcttca 1835461 tctcagtcac gtttctcggc gccgtgtagg tctccgcatc tgccgctccg ccaggagctg 1835521 gcagggcgtt tcggtcgagc tttccgcttg gcgtaaccgg ccactgttcc atctctatca 1835581 tataggctgg gaccatgtag cccggcaaca gtctctcaag ctgtgcacgc acttcgtttc 1835641 tttggagccc ttctacataa gcgcataatt ccggctcccc gctgtctgtc cgtacggtaa 1835701 cagccgcctc tcttacgcct tctatgcttc ttagtgccgc ttcaatttct cccggctcaa 1835761 tccggtagcc gcggattttt acctgatcat ccgtgcgccc gaggaattca acattcccgt 1835821 cagggagcca gcgcgccaca tccccggttt tgtacatgcg ttcccccggg taaaacgggt 1835881 cttcaagaaa acgctcctcc gttaatgccg gccgattcaa ataacctctg gcaacacccg 1835941 ctccggcaat gtacagttcg ccggcgacac cggaaggctg tacggctaaa tgcggatcta 1836001 aaacatacaa acgcgcacca ggtacgggct tcccaatcgg aatccgcaaa cgatccctgt 1836061 cccgttctgg atccaatacg taaaatgccg cgtctaccgt tgcttctgtc ggcccgtaac 1836121 catggattaa tgatacctgc ggcaatacag aagcaaaacg ggctgccgta cgcggcgcaa 1836181 gcggttcacc tccggcgaat acacgcttta ggcttgtcct gtcactcagc ctttcgattt 1836241 ccgcttgatc gagaaagctg ttcagcatag ccggaataaa atgagccgtt gtcacgtttt 1836301 cctgatgaat ggcttgtacg atcaatgcgg agtctttctc ccagccgggc ggaagcagat 1836361 acgccgaagc accggaaagc gaccaccaaa acagctgcca cacagacgca tcaaaggaaa 1836421 aagaggtttt caccatgaca atgtcatctt ccgaaagcgg aaactggtgc tgcatgccgg 1836481 tcagaaagga aacagcctga cggtgctcaa cggccactcc tttcggctgc ccggtagagc 1836541 ccgatgtata gatgacatag gcgagagatc cgccgtcagc aggagtaaac tcatggtttt 1836601 ctgctttttc gctcgcaaga gatgtcatgt ccacttcaag cgtttcgcca gaaaagtttg 1836661 gtgcggagca tcccggctgt gtcagcaaga gcgatgcccc gctgtctttc agcatgtagc 1836721 tcagccgctc ctttggatac gcaggatcaa gcggcaaata cgccccgccg gccttcaata 1836781 cagcaaggac agcgatcagc atgtcaggtg agcgttcaga caggacaccg acgatacttt 1836841 cgtttgtgac gccgcgtgcc gcaaggtgcg cagccagccg gctggcgtac atatcaagct 1836901 cagcgtatgt cagcgaaccg cctgaaaagc gaatggccag ccgctccggt gtgaaagctg 1836961 cctgtcgctc aaacagccca tgcagggtga aagctttagg cgaaacagct tccgtcttgt 1837021 taaactcata caacaatttt tgcttttctc ttgtattcgt catatctaat tctcttataa 1837081 agctgtgcgg atgtttaagg gcgttttcca gtatggtaag cagatgagat tgtattcgtt 1837141 taatatcctc aagagaaaac aaggtatttt gatagtcgaa atttaattga atggttccat 1837201 tgtctatccg ttcttgtatt tgaactgaaa gttcgttcgc ggtgtatccg ctgaaataaa 1837261 gcgctgtttc atagtcaaaa tcatctgcat tgtgccactg aagtggctga tactgcatag 1837321 atataccgat aaggttgtgt aaatccttct gttcatttct taattcattt acaagcaaat 1837381 tataaggaaa ccgttgatga cgcataacag aaagctgttc cctgcctatt gtgcggacaa 1837441 aggaaagaaa atctgtgtca ggatcaaccg ttattctgat tggaagggaa ctaacgaaca 1837501 tgccgagcat ttctttttca gcctttgaac ctctgttgcc atagtaggtg ccaatggcaa 1837561 gatctttttt agaagtgatt cggctgatgc atatgtaaaa tgaagccata aataaggaaa 1837621 tgatattgat cttgtgttct tcgcagaaga ttcgaatcgt ttgctctaga tcaggtgaaa 1837681 gaatgatggt gtctctggat gcagatgtgc tctgtttttg taaggacgtc tggtcggcta 1837741 acgagtggta ttccaacggg tgctcaaagg tttgcgtcca aaataaacgg tcctttgcaa 1837801 accgtggaga ttgtagatat tgactctctt tttcgatgta gctcaagtaa gaaggttccg 1837861 gctgatcagg taaaggatct ttctttttca ttttttgata aagatctata atttgatttc 1837921 ccatcacatt taaagagatt ccatccatta tgatatgatg gaatttcgca aatagccaaa 1837981 cttcatgaga gtcaattcta aggaggtaaa attgaaaaag aggcgagttg aacagtttaa 1838041 atggaatgct cgcttgatcc tgaatccatt gctctatttc tatcatttca acatttgaaa 1838101 aatcaattat tctaagtgga taatatttat attcagtaag gtgcaatcga ggctcaagct 1838161 cttctccttc taacagctga aatctaatgg cgtcgttgcg ggagatggaa tgattcagtg 1838221 ctccctccag agtatcaagc tcaatattgc ctttaaattt cacacaagct gtaagattgc 1838281 aaatgctggt atctggctcc agcagttcgg taaaccacac tctcctttgg gcatgggtta 1838341 aagaataagt atgttcgctc aacggattcc ctccagttct cataataaga ggataagaaa 1838401 atgtagaaaa aagcagaaaa atgacaataa aagaaattat atgactatat aatccatata 1838461 tgcactatat taacggatat tttttaaagt acaataaaaa acattaaatt tttataacat 1838521 tttttttgaa tatagtatta tttctttatt tttcgtttct ttttttatca aatttccgga 1838581 tataaagtga taaaagtatt gttttacata aggtcttata cactactttt taatcggact 1838641 aattttcttt tgtgcatcat tcttctaatt gttggaaggt tcgacaaagc gttattacag 1838701 acataaaaaa acctgttttc tcttggaaaa caggtctccc gctattattg atttgccaaa 1838761 atgacagcga tttgatcctc aatatctttt ccatcctctt catcaatcaa tccatttaga 1838821 agaatagaga aaacaagttt ttttccgctc tttgtttctg cgtaccccga tagagagctt 1838881 accgtactga gcgatccggt ttttgctctt acttttcctt gtgcaggagt gcctttcatg 1838941 cggtttctca gcgttccgcc caccattctg tcaggattcc ccgcaacagg taaagaattt 1839001 agataagccg agaaccaact ctgatcctga atgtcatata acagctgtga aagttgatct 1839061 gaggatacag catcaatatg tgagattcct gatccgtccc ttaagacgag tgatttagaa 1839121 tcaacaccaa attccggaag cgtactgttt aacacttcga gccccttttc ccagctccct 1839181 tctccttttt tcactttccc catctctttt acgagcactt cggcatgtcc gttattactt 1839241 aatttcatga acggcacaaa aagtttcgat aaaggcattg agcgatgaga gagcagcaca 1839301 tctgaagaac taggtgcttc acccgtcttg atgtcccctt tcacagtaat accttgtttt 1839361 tttagtgact gcttaaataa atctaaggca tatccggcag gctcccagac agaaatccat 1839421 tcctttgtct tgtttgcgtc aaccggtacg ctcccttcaa ttgtaatcgt gtttgttcca 1839481 tgctctcttt cgattgtgag gtctttctct gaaccggcag cagtcgtttt agcatcgttc 1839541 tttatcgtta tataatcggt tttcggagag acagacacgg caggctcttc cccttctttt 1839601 tgatttgggg tgacctcaac aatcacagtg cctgcatcat agtcttcgtt tggagacgct 1839661 gttagagcgg agattggcgc gccataatat gtgtattcat cgctccaagg catatcaggt 1839721 gataatcgca tgtcatcatg ccacgtatca tcaccgatca gattgccttt aattactttt 1839781 acgccggaat gtttcaatat ctcagccatt ttgtcaaaat cagatggtaa aagtgtcgga 1839841 tcgcctttcc ctttcaaata aaggttacca ttcagctttt tccctttcag tgttccatcc 1839901 gtccggacct cggttgtaaa agaatagttc tcgccaagga cagaaagtgc cgcggccgct 1839961 gtcaaaagct ttagagaaga ggcaggcctc attcgggtgt ctcctgaatg ttcatataga 1840021 acagcacctg tttccgcaga gcgaacggtg atgccggcca ttgcgccttc gagggcagga 1840081 tgatcagcta aaatcttatc gatctgcccg gaaagtgcat cttgtttttc agcggcaagc 1840141 gcagcctgat gcatataagg caccgaagca acgacgaaaa gcagtaaaac agcaacataa 1840201 agctttatgc tttttttcat taatttcccc gcctctctgc gcttcatcat tggctattga 1840261 tgattcagtt caatggtgat actgctttta gctgtcgttt cttctcccgg ctccagcact 1840321 tgtaaaccag tgagtgacga aggtaaatca agattcactg cgtttgtcac ccatgtgtaa 1840381 ggctcagggc ataaataccc ttgttttccg tccgcattgt atacaaccca atgtttaaac 1840441 tgttcatctg ccttataaat aatgctgata tgtgcatgct gatgataaat gactgcctgg 1840501 ttttctccgc ccctcttctg ataagaagat aaaaagacat catccagctg cttgtggcgc 1840561 aaatccattc cttcatgcaa agcttcttta tacgggacat ccatcagctt cccggtcggc 1840621 agcaggcgtt catccaactc ccattgctga tctgctgtca gggagaataa cgagctttct 1840681 gccggaaata taaatgtagt atgataacca attccccaag gaaacgcttc ctttcctttg 1840741 ttcatgaccg tcgcatgttt aaatagggta ttctccttga tcgtgtatgt catccgaacg 1840801 acggcatgat gaggaaattg cttctgcaca tggggaagct cagaaagatc aatttctgtt 1840861 tcaacaatca ctccttcatc agtttgcttc gtggtcacga cattccactt ttcatggtaa 1840921 agaaacccgt gaagatggtt gtgtttatcc ttctcgttga tatcaaaatg atacgttctg 1840981 ccccggaaac tgaatgtacc gtcacttatg cggttaggcg ggaacaggat tggaatgcca 1841041 tacaatgttg gtgtgtcgtg aaaactttct gctgtttccg gttcacgcaa aagctggaca 1841101 tttgttgttt tgtccacgag agaaatgacg ttgctccccc actcagggac aacaatcatt 1841161 tctagatgtt cgttgcccgc tttgatggcc ggcgttccca aatacgtgat tttctcaata 1841221 aagtttgcca tgtttactca acctctcctt gattcattgc tagtataaga attcaatgta 1841281 ctgtaccata tttcctccat tttatatttt cccctatcaa ataaaaaaac accgttcaaa 1841341 cttatgaacg gtgtgattcg gaggctattg gatgagacgt gtgatttgtt tctttttcca 1841401 gacgaattga taatacccat aaatcaacag caagctgacg gcaaacgcag ctggataacc 1841461 aacccagacg ccgagtattt caagctttgt atagtgagaa aggacgaaag cgacaggcac 1841521 ctctactccc cagattgcaa aaatactgat gacggtcggc cataaaactg ttccgcttgc 1841581 ccgcatcgtt gcagaaataa tttgggcatt tccaaacagc aaatagctcc acagtgtaat 1841641 catcaaaaga cggtgcgcaa tgtaaagcgt ctcttgctcg gttaaaaata acgataaaat 1841701 ctgatgtgaa aaaacataga tcagaatgat cagtacgccg ccaatgatat aattcagcca 1841761 aatcccaacg cgaatgacct gctttaagcg gtcaaactcg tttgctccga tcgattgcgc 1841821 agcgaaaata gaaaccgcaa taccaaggct gacggccggc atctgtacat agctggccac 1841881 ctggttgacc actccgtatg cagctgttgc attagagccg taatgattga cgaatgaaat 1841941 aaccgctatc tctgataatg agacaagaat catattgatg cttgctggga ccccaagacg 1842001 cagcaggaga accagcagtt ccttatccat tttcaaataa cgacgcactg ttttatcaaa 1842061 ttgcagcggg tgttttcgct ttcgtaaata caccattaac acgagaaaag tcgcaatcgt 1842121 ggaaatgaca gttgcatatg ccgagccgta tatgcccagt ttcggaaaac caaacatgcc 1842181 aaggattaaa acaggcaaaa gcgcgatgtt gatgaccgtg ctcacaatca gcgtataaaa 1842241 cggtgtcttg gaatctcctg ttccgcgcaa aaaggtagta tatgcaaaat ataaaaacat 1842301 aaacggcata gcataaaata aaatacgtgc atagttagcg ctgacatgaa tgacattttc 1842361 aggtgttccc attaaacgaa ggatatccag ggtgaaaata ctgccgataa cggctaacac 1842421 aacgcctaat aaaaatgtaa acgtgagtgt cgtcccgaca acagccttta gccgttcctc 1842481 atttttcgct ccgtaagctt gtcctatcag aatcgaactt cctgaaccga tcccaatcgt 1842541 aaatgagatt aaaagaaaaa ataacgggaa aaaggatgat acagctgcca ctgcatcaac 1842601 accgagccat ctgcctacag ccatcatccc gactagctgg ccgactgatt gcagcacatt 1842661 gctcagcaga agcggcacta aaaagagtga catcgaccgc caaactgatg gtttgctttt 1842721 cttttgagtt acaagaggtt cttgtgatgt ttccatatta aaggactcct ttatttgaaa 1842781 tcgtttttaa acatgccctc attttttgac aaaaacagga tatgtaacat gttattattc 1842841 atcactgcac ttatgaaacc cttcccgatt cttctaattt tacacatctt tttagcttat 1842901 gaagaataaa ctagcaagta atggcgtatt ttttgtgagt aaaagaataa aaaataattt 1842961 atgcaaaagt attgtaatct atccgtaatt attgtaacat ttgtaacata agagaaagag 1843021 attttgaagg agagagcgat aatgaaaaaa tgtcttctat ttctaacaac cattgcactt 1843081 attctgtcat taagcacaaa tgcatttgcg aaaaatacat caggcgattt atcacaaaaa 1843141 caagcattac agttggcatt atccgctaga gaacattttt ggaacaccat gagcggccac 1843201 aatccgaagg tgaaaaaagc agtttgccca tcaggcacat tcgagtatca aaatcttcaa 1843261 tatgtataca tgtgcagtga tctaggcact aaagcaaaag cggtgaatta tttaactcct 1843321 atttttacaa aaacagcaat cgaaaaaggc tttaaagatt atcatttcac tgtttcaaaa 1843381 ggaaaacttg ctgttccaat cggtgacgga gacaatcttt tgaattggaa aaaatcaact 1843441 gctaaactga tctctaaaaa aggcagcaca atcacatacg aatttactgt ccctacatta 1843501 gacggatccc cttctgcaaa acggaaagtg acatttgtga aagaaaataa aaaatggaaa 1843561 gtcaatcaat ttgacgcagt tatataagaa aaacgcccgg tataagcggg cgttttttat 1843621 ttggtttgca taaagaaaga caacaggcga aaagtgcctg ttgtcttttt gtgaatataa 1843681 cgctctagga gagattcgaa ctcccgacct gcagtttagg aaactgctgc actatccgct 1843741 gtgctactag agcttttggt atttatatag tagctctgat gatcaatatt ttcaagcgat 1843801 ttgtattaaa gccctccaaa aaccttatat gcggctcttg tcgtatcttc atcaataccg 1843861 atataccgca ttgtaattga tggtgatgaa tgattcagta ttctctgcag ctcggcgatg 1843921 tctttcgttc gctgataaaa atgatagcca aacgttttcc ggagtgtatg cgtccctatc 1843981 tcctcaagtc cgcacgctgc agcggcctct cttaaaattc tgtaggcctg aatgcgggaa 1844041 atcggcttcc tggtccgcac tgatttaaaa agatattcgt tttccttcat gtctttcgta 1844101 tactcgtata tttcctgttt cagcgattct aaaataagaa tctttctttt ctttttcgtt 1844161 ttgctttcag tcgcccataa atgatcttta ttttgaacgt ccttcacttg cagcggcaga 1844221 atatcagaaa tacggagcgc gctgttgatg ccgaaaataa acagaaaata atcccgcttg 1844281 tttttgttaa gcaaatactg tttgacttct tggattttct ctagactgcg aatcggctgt 1844341 acaatatgca tcaaaaaact ccttaaaaac cgttatgtaa cattttgagg tctatgttac 1844401 tattatagct gaaaaacgtt gaatgtcaaa gtgcggcggc gtttatgtaa cataatatac 1844461 atagtgttac ataagctttt aaaaaagctt cttccaacct tcaccctata aaataagctt 1844521 taaagcctct tataaagctt ttaacctctt ggatacttat ccccctacta atcatcaaaa 1844581 aacctcttaa aatgaaatct gacactccca attttctgga gcttccgcaa aaatatacaa 1844641 aaaaagacac aatttcaaat tgtgtcctaa tcctcatcct ttacatcaat atcttccggg 1844701 atcggttcat ttaatatttc ctgcacaagt gctttgtaat tctccagctg ttcgagatgc 1844761 gttttgaact gttccttata aatcaaaaat tgctccccgt catgaacggc tctgattttc 1844821 ccttcgagca ccaagctttt aatataatcc tctgaaagat ttgtatattc tgctgtttct 1844881 tcaatcgtta aatacatata gcagtccctt cttaatccgt atgctgattc taatatagca 1844941 catggctcat atcaatataa tcaattctgc acagaaaaac ggcattatgc actatataat 1845001 ataccatttg tcacttgtga aaacgctgta atttttttac gctaagattg taacaataca 1845061 gcttcatata ggagggagaa catgaaaaga acgtggaacg tctgtttaac agctctgctt 1845121 agtgttctgt tagtcgctgg aagtgtccct tttcacgcgg aagctaaaaa accgcccaaa 1845181 agctacgatg agtacaaaca agtagatgtt ggaaaagacg gcatggttgc gaccgcacat 1845241 cctcttgctt ctgaaatcgg tgctgatgtg ctgaaaaaag gaggaaatgc tattgacgca 1845301 gcggttgcca ttcaatttgc actcaatgta acagagccga tgatgtcagg tattggcggc 1845361 ggcggtttta tgatggtgta tgacggaaaa acgaaggata caacgataat cgacagccgt 1845421 gagcgtgctc cagcaggcgc aactcctgat atgtttctgg acgaaaacgg caaagcaatt 1845481 cctttctctg aacgtgtaac aaaaggtact gccgttggtg ttccaggcac tctgaaaggg 1845541 ctggaagaag ccttggataa atggggaacc cgttcgatga agcaattaat taccccttct 1845601 attaaactcg ctgaaaaagg ctttccgatt gattcggtgt tggcagaggc catttctgat 1845661 tatcaggaaa agctttcacg gactgccgca aaagatgtat ttttaccaaa tggcgaaccg 1845721 cttaaagaag gagataccct tattcaaaag gatttggcta aaacatttaa gcttattcgc 1845781 tccaaaggca ctgacgcttt ttataaagga aaattcgcca agacgctttc tgacactgtc 1845841 caggatttcg gcggatcaat gacagaaaaa gatttagaaa attacgacat tacaattgat 1845901 gaaccgattt ggggagatta tcaaggctat caaatcgcta ctactcctcc tccaagctcc 1845961 ggcggtattt tcttattgca aatgctgaaa atccttgatc attttaacct ttcacaatac 1846021 gatgtccgct catgggaaaa atatcagctg cttgctgaaa cgatgcattt gtcatatgcc 1846081 gaccgtgcgt cttacgcagg tgatcccgaa tttgtaaatg ttcctctcaa aggcctgctt 1846141 caccccgatt atattaaaga acgccagcaa ttaatcaacc tagatcaagt gaataaaaaa 1846201 ccgaaagccg gtgacccttg gaaataccaa gaaggatcag caaactataa acaagttgaa 1846261 cagccgaaag acaaagtaga aggccaaaca acccacttta cagttgctga ccgttgggga 1846321 aatgttgttt cttatacaac aacaatcgaa cagctattcg gaacgggtat tatggtccct 1846381 gattacggtg ttattttaaa caatgaatta acggattttg atgcgatacc aggcggagct 1846441 aacgaagtac agccaaacaa acggccttta agcagcatga ccccgacgat tttatttaag 1846501 gatgacaagc ctgtcctcac ggttggatct cctggcgggg ccacaattat ttcatccgtt 1846561 ttgcaaacca ttctctacca cattgaatat ggtatggaat taaaagcagc tgttgaagag 1846621 ccgagaattt acacaaacag catgagctct taccgttacg aagacggagt tcctaaagat 1846681 gtcctcagca agctaaacgg catgggccac aaattcggca caagtccggt ggatatcgga 1846741 aacgtgcaaa gtatatcgat cgaccatgaa aacggcacct ttaaaggtgt agctgattca 1846801 agcagaaacg gcgcggcgat cggcattaat ttaaaacgta aataaataaa aaactgtact 1846861 cgcttcaaat gagtacagtt ttttcatgca gatctttaaa ataaaaactg acaaacgtct 1846921 ttattctgct aatgcacgtc tatcttcatc ttttcatttc gtttatctca tcaagaaatg 1846981 tctgaaacgc actcgtaata aaaaagtctt tcctgtatat aaagacgatc tctaagtctt 1847041 gatatgatgg tggcagctga tgaatccata catttgtacg atgctcggag ccgtcaacag 1847101 cggactttgg gagcagcgcc gtacccatcc cggcggaaac accttttata atagcctcca 1847161 atgtgccaaa ctctatgatt ttttgattgt gtatgcctgc ttcctctagt aatcttttga 1847221 ccctgtcacg atgagaacag ccagccccaa aaaagagcat cggctgctga agcatgtctt 1847281 ctgccgtccc ttctcgtgat gaaatcaaaa ctaattcatc atgggagaca tggagttgtc 1847341 taactgcagc gtgttcaacc ggcccatata caaaagcgcc atcaacttta tgatcaagaa 1847401 cctgttgaat caaatgatgc gtatcagctg tgttcactga taaatccact tcaggaaaac 1847461 gcctgaggaa ggatgctgca tgctcaggca gatgcgttac cgccattgtt tccagtgatc 1847521 cgatccgcaa aggccctttt ggttgcctgc tcattcgggt cgatttttca gcttggtcta 1847581 acagcgataa tacttgatct gcatattgta aaagattttc tcctgcagca gtcagcttca 1847641 ttccccgatt cgttcgatga aaaagcctga tattcaaatc ttcctcaagg ttatgcactc 1847701 tggctgtcac attcgactga acataattca gcatttgggc tgctttcgtt atgcttcctt 1847761 cgcgagcaac agcctgaaaa atctttaaat ctccgctttc cacgcgctct cacctgcttg 1847821 ctatgatgaa aagtgatatt ggctatcata tttgttcatt ttactcgaag aaaaccgcta 1847881 tgtaaaatat gtaaagatat gaaaatacaa ttaatgagga ggcagacagc atgaaagctg 1847941 taattcacaa cggaaaagcc ggtcttctgg ggttatcagt tcaggacgtt ccatcaacaa 1848001 agcctggata cggagaggta aaggttaaat taaaatctgc aggcctgaat catcgtgact 1848061 tgtttcttat gaaaaacaaa tctgaacaag atcctcacat gatactgggt tctgacggcg 1848121 cgggtatcat cgaagagatt ggtgaaggcg tgaaaaatgt tactgttcag acagaagtag 1848181 tcattttccc gacattgaac tgggatttga cagaaaatgt tccacctgta cctgagattc 1848241 tgggaggtcc ttcggacgga acacttgctg aatatgtgat cattccttca caaaatgcaa 1848301 tcaaaaaacc tgcttattta tcttgggaag aagcgggcgt tttaccttta tccgctttaa 1848361 ctgcatatcg ggctctgttt acaaaggggc aattaaaaaa aggcgagcat ctattgatac 1848421 ccggcatcgg cagcggtgta gcaacctacg ctttatttat ggctaaggcg attggggcaa 1848481 cagtaagcgt gacctcccgc agtgaggaga aaagaaaaaa ggcgctgaaa ttaggtgctg 1848541 attacgcatt tgacagctac agcaattggg atgagcagtt gcagggaaaa aagatagatg 1848601 ttgttcttga cagcatagga cctgccctct tttcggaata cttccgccat gtaaaaccaa 1848661 atggccgtat tgtcagcttt ggggcaagct caggggataa tctcagtttt ccggtgcgtt 1848721 ctttattctt tcctcaggtc aatgttttgg gaacctcgat gggaagcggt gaggaatttc 1848781 aagctatgct cgctttcatt gacaaacata agctgcggcc tgtaattgac cggatatatc 1848841 ctttagaaaa agcatgtgaa gcatataaaa gaatgcagga aggcagacag tttggaaaca 1848901 tcgggatcgt aatggaataa aaaaagaaac cggctggcag ccagaccggt ttctcttata 1848961 tgataatccc ctttatttac ggaagaactg aactccccat caaatatcga tccacttcac 1849021 gcgccacttc acggccttca ttaatcgccc atacgattaa gctttgccct cttcttgcat 1849081 cccctgcggc gaatacacca tcgatatttg tttgataatc cccatatgct gcactgattt 1849141 tgttatttac tgaattaaca ccgaactgtt tcaacagcgg ctgttctgtg ccttcaaagc 1849201 cgatagcgat aaagacaagc tgagcaggcc atactttttc cgttccaggc agctcgcgga 1849261 actcgtattt tccatgctca tttttcactt tttccatttg gatggtatga agctctttca 1849321 gctttccgtt tttatccgcg accatttttg tcgtttgaat ggagtattct ctcggatctc 1849381 ttccgaattt tgcttctgct tcctcgtatg catattcaag cgtaaagacg tgtggctgtt 1849441 caggccacat attgtcattc gtgcgggctg gcggaagttt cgggtgtttg ccgaattggt 1849501 gcacgctttt ggctttttga cgcagagcgg tagccacaca gtcagctcct gtatctccgc 1849561 ctccgattac gatgacatct ttccctttgg catcaatgaa ttgcttgtct ttaaaattag 1849621 aatctaaata gctttttgtt gcaagtgtga ggtagtccat tgcgtaatgg actccttttg 1849681 agtcgcgtcc ttcgattaag aggtcccgct gtttttgagc gcctgtgcat aagatcacag 1849741 catcaaattg ctcctttagc tcatcagctg taatgtcaac accgatttct gtgttcgtga 1849801 caaaatcaat tccctcttgc gtcagcaatt taattcggcg ttctacaatg cccttctcaa 1849861 gcttcatgtt tggaatgccg tatgttaaaa ggccgcccgc tctgtctgct cgttcaaaaa 1849921 cagtgacgga atgtcccgct tgattcagct ggtcagcact cgccagtccg gctgggcctg 1849981 acccgacgat ggccactttt ttgcctgttc gtttttttgg aattctaggt tgaatccagc 1850041 cgttctcaaa tcctttatcg ataatggtcc gctcgatgtt tttaattgat acggccggat 1850101 ctgaaatcgc taaagtgcat gatccttcac aaggagcggg gcatacccgc cctgtgaatt 1850161 caggaaagtt gtttgttttc aacagacgtt ccaatgcttc cttccatctg ccccggtaga 1850221 caagatcatt ccattcagga attaagttgt aaatcggaca gccggatgta aatccgttaa 1850281 tgtccgcacc gatctggcaa aacggtgtac cgcaatccat acaccgcgcc ccttgccgtt 1850341 tcgatgcttc ttctgaaaaa ggagcagaat attctttcca atcctttaag cgagtgagag 1850401 ggtcccgctc cgcaggtttt tctcgtttga tctccataaa tccagttggt ttccccatgt 1850461 tcctctcccc ttccttactg tactaccgct tgtttttgtc ccgatgctgc tgtattctgc 1850521 tttggcttcg tgttggcctc aaaagcgaac atgatggctt cttcatctga taaacctgca 1850581 gctttttgct cttcgatgct tgcgagcatt tgtttatagt ttttcggaat gactttgacg 1850641 aattttttca cactgtcttc ccattgatct agcagatctt ctgctttttg gctgtttgta 1850701 tacgcagtat gtctttcaag cattgctttg atttgctgga tttctttctc atcctctaat 1850761 gattcaaata aaatcatctc aaggttgcat ttgcgtttaa acgctttgac atcttcggtc 1850821 agtacataag cgattccgcc ggacatacct gccgcaaagt ttttgcctac atcaccgaga 1850881 acgacaacgc tgccgccagt catgtattca cagccgtggt cgccgatgcc ttctacaact 1850941 acgttcacac cgctgtttcg aacggcaaag cgttcaccag cacgcccgtt aatatatgct 1851001 tctccgcttg tcgcaccgta aaaagccacg ttgccgataa tgacattgtc atccgaagca 1851061 gagttgaatc cttctgatga cttgacgatg atttttccgc cagaaagccc ttttccgacg 1851121 taatcatttg agtctccgtc caaataaagc gtcatccctt taggaacgaa agctccaaag 1851181 ctttggccgg ctgatccggt aaagtgcagc ttgattgtat cttcaggaag accttcttct 1851241 ccgtaacgct ttgagatttc actgccggtt atcgttccgg ctacacgatt tgtattattg 1851301 atttcaatcg aaatatcagc ttcttttcca gattcgatgg cttcttgtac ggccgggaga 1851361 attgttgtaa tatcaagtga ttgatcaatt ttatgatttt gcggcgattg gaacgtccgc 1851421 accccttcag gctgataaag aagggtagac aaatcaagct ggcttgcttt ccagtgctcc 1851481 tttgcccgtt cacttgcatg aagtacatca gtgcggccga tcatttcatc aaatgtcttg 1851541 aagcctaacg cagccatgta ctcacgaact tcttcggcaa tgaacagcat atagttcaca 1851601 atatggtcag gatctcccat gaactttttg cgaagctctg gattttgtgt cgctacaccg 1851661 acagggcatg tatccaaatg gcaggcacgc atcatgacac agccgagtac aactaacgga 1851721 gccgttgcga aaccaaattc ttcggcgccg agcaaggcag ccatcacaac gtcgcggccc 1851781 gtcatgagct ttccatctgt ttctaataca acacggtcac gaagtccgtt cagcattagt 1851841 gtttgatgtg cttctgcaag gccaagctcc cacggaagcc ctgtatgttt aatactggtt 1851901 ttcggagaag cgcctgtacc tccgtcatag ccgctgatca caatgacatc tgcagtcgct 1851961 ttggcaacac ctgcagcgat tgttcctaca cctgcttttg acaccagctt tacgctgatt 1852021 cttgcgtcac ggttggcatt tttcaaatcg tggatcagct gggctaaatc ctcaatcgaa 1852081 taaatgtcat ggtgtggcgg aggtgagatt aatccgacac ctggcgttga cccacggaca 1852141 tcggcaaccc atggatatac cttgttgcca ggaagctgcc cgccttcacc cggcttagca 1852201 ccttgagcca ttttaatctg cagctcatca gcattgacga ggtaatggct tttgacacca 1852261 aaccgtccgg atgcaatttg tttgatcgca cttcttctat catcgccgtt ctcatctgga 1852321 acaaagcgtt tgggatcttc tccgccttca ccgctgttgc tttttcctcc aagacggttc 1852381 attgcgattg ctaaagcttc gtgcgcttcc ttactcaagg acccgaatga catcgcaccc 1852441 gttttaaaac gtttgacaat cgattcagcg gattcaacct cctccaactt caaaggcttg 1852501 cggtttccgt caaatgcgaa caagttccgc aaaaatccga tgcgttcttc atcagccgct 1852561 tttgtatact gtttaaacag attgtaatca tttctgcggc acgcccattg caaagtatga 1852621 atcgttttcg gattaaacgc atgatgctct ccgccatttc tccattggaa gtcacttccc 1852681 ggttcaagcg ttttgctgta atcatcctga tacgcttccc ggtggcggcg ctgtgcctct 1852741 tctgcaattg tttgtaaatc gatgccgcct agctgtgatg cagtacctga gaaatagcgg 1852801 tcgatcacat cgcggctgat tcctaccgcc tcaaagattt gtgcgcctct gtagctttgc 1852861 acagttgaaa ttcccatctt ggacatcact tttacgacgc cctcagtaat gctttttcca 1852921 tatttgctaa ccgcttcttc atagctgata tccaaacggc cttcatcaat ttcctgcttg 1852981 taggtcgcat aagcgagata agggttaatc gcatctgcgc cataaccgat taacgctgca 1853041 aagtgatgca cttcacgtgc ttctcccgat tccacaataa tgctgacctt cgtacgcagc 1853101 cctttgcgga ttaagtgctg gtgcagtgcg cttactgcca gaagcggcgg aattggtgtc 1853161 agtcgttcgt tcatcttttt gtctgataaa attaacaaac ttacgccttg gctgatggct 1853221 ttctctgcct gtgtgaacat gtcctttaaa ccgcgttcaa gatcctctga aaacagcaca 1853281 tcaatttttt ggctttttaa atcaggatga acaatcgttt tcaatgcgta aaactgttca 1853341 ttggataaaa caggtgtata cagtttaatc cggcgaacat ttcgttcact tggatgaaga 1853401 agatcgcctt ccgcaccgag ccaagtcatc gttgaagtga caagctgctc acgaatcgcg 1853461 tcgattggcg ggttcgttac ttgtgcaaac agctgtttaa agtagttaaa cagcgattgc 1853521 gctcggtcag aaagtacagc aagcggagcg tcattcccca ttgaaccaag gggatctttg 1853581 ccttctttaa taacaggaat tagatacttt tggatatcct catatgtgta tccgaatgcc 1853641 ttctggcgag taagaagatc actaaattgt tcttcttctc ttgactccgg atcaggattt 1853701 acttgtacaa gctcttcttc aagccatttt tggtacggat actcagttgc aatttgtgtt 1853761 ttgacttcct catcggagat aatacggcct tcttccaggt cgattaaaag cattttccca 1853821 ggctcaaggc ggtttttata taaaacgttc tcctgttcaa cttcaataac gcctacttca 1853881 gatgagaaaa taatataatc atcttttgtg acataataac gggccggacg gagaccgttc 1853941 cggtcaagga tcgccccgat ttgtttaccg tcagtaaatg aaatagctgt cggtccgtcc 1854001 caaggctcca tcagggagct atggtactcg tagaacgccc ttttttcctt ggacatatgc 1854061 gtattttccg tccaaggctc tggaatgagc atcattgccg tatgtgccgg tttgcgtcca 1854121 gccatcacaa aaaactcaaa tgcgttatcc aaaatggaag agtcactgcc atcagcattg 1854181 agaatcggca aaatcttgtt taagtcctca ccgaagcttt cagaaacaaa ttgctgctca 1854241 cgtgctctca tccagttgat atttccgcga agggtgttaa tttcaccgtt gtgaaccaaa 1854301 tagcggttag gatgcgctct ttcccatgta gggaatgtat tggtactgaa gcgtgaatga 1854361 acaagcgcaa aagcagaaac gaatgcttcg tcttgcagat cagaataaaa tgcatcaacc 1854421 tgttcaggtg ttaaaaggcc tttgtaaaca atggtctggc ttgaaagact ggcaaaataa 1854481 aaatcaagac cttccgttac tccccaattt tcagcctgtt tacgaatgac atacaatttt 1854541 cgttcaaaag ataaattgtc ctttagatca gaacttgcgc cgataaatac ctgacggaca 1854601 aacggacagc ttttttgcgc cactgttccg atttttccga catttacagg tacagttctc 1854661 catccaagaa cgacttggcc ttcttgttca attagtgcat tgatttgctt ttcaattttt 1854721 tttctttcat cttccttctg tgagaaaaag accattccta ccccgtaacg ttctttttct 1854781 ggcagattga tgtttttgca ctcttttcta aagaaagcat cagggatttg aaccagtaag 1854841 ccggctccgt ctcctgtatc cggatcactg ccttgccctc ctctatggtc tagctggcaa 1854901 agcatcttaa gtccttgttt gacaatgtcg tgagtctgct tgccctttaa gtgtgcatat 1854961 aggccgattc cgcatgcatc atgttcaaat tcaggacggt agagaccttg agcttttggc 1855021 atttgattgt acgtcataat tcctctcccc cgatcaattt ccgataatac cggtcataaa 1855081 atctaacaac tctataatca ttgtaggttt tcaaaacgat ataaacaata tataatttag 1855141 atcaaaagaa tctcaaaatg agatagatgg atgtgagaca aacatggagc tgcgccaact 1855201 gcgttatttt atggaggtgg ctgaaagaga acacgtttca gaagccgctg atcatttgca 1855261 tgtggcccaa tcagcaatca gcagacaaat tgccaatctt gaagaagaat taaatgtgac 1855321 cttatttgag cgtgaaggga gaaatatcaa actcacgcca atcggaaaag aatttttaat 1855381 tcatgtgaaa acggcgatga aagccattga ttatgcgaaa gagcaaattg atgagtatct 1855441 tgacccgcat cgcggaacgg taaagatcgg ctttcctaca agcctcgcca gccagctttt 1855501 gccgactgtc atttcagcgt ttaaagaaga atatccgcac gtcgaatttt tgctgcgcca 1855561 aggctcctat aagtttctga ttgaagctgt cagaaaccgc gatattgatc tggccttatt 1855621 agggccggtg ccgacgaatt tctctgacat aacgggaaaa atattattta ctgaaaaaat 1855681 ttacgcgctt gttccattaa atcatccgct tgctaaacaa aaaacggttc atttaatcga 1855741 tttgcgcaac gaccaatttg tattgttccc ggaaggattt gtacttagag agatggcaat 1855801 cgatacttgc aaacaagcag gctttgctcc tctcgtttcc acggagggtg aggatttgga 1855861 tgcgatcaaa gggttagtgt ccgcaggaat gggcgttacc cttctgcctg aaagtacttt 1855921 tgctgaaaca acacctcgtt ttactgtgaa aattccaatt gagttccctc aagtaaaacg 1855981 gactgtcgga atcattaaac cgaaaaatag agagcttgcg ccttccgcga atgattttta 1856041 tgagtttgtc attcaatttt tctctaagct ggagcagtat caataaaaaa aatgaacccg 1856101 agcttctata tagaagcttc gggttttttt ctgcaaatta atttacaggt aaagaaaaat 1856161 ccacatggca aacaaatgct tcttgatcaa ttagagctct atttgtcagt tcctttttct 1856221 tttccggttc ttgaagctgt acagaagagt aattgacgat tccaaggccg atttccgtcc 1856281 cttttgaatc catcagccga acaactgaac cgcttttgaa tttcccttta atcttctgta 1856341 caccgtctag gtataaactc gattgtccgt ttgttatttt tcgtgaacaa tcatctgata 1856401 aaatcatttc accttccgga ccggaattaa aagcgatcca ttgctccttt tgattcaacg 1856461 gaagcgttcc ttctgcttca aaataggtgc cttccgcctg ttcatgaacg gcgtggtata 1856521 aaatatcgcc agcatctgcc tgacctagga aacctttaat gccagacgcc attacgattt 1856581 taaacgcatc aagcttagag cgcatgccgc cggtgccaac gatgcttcca gtgtcacctg 1856641 cgcatgcttc gatgtcaggt gttatttcac tcacccgctg tatctttttc gcttctggat 1856701 ttgtgcgcgg attgccgtca tataatccgt ctatatctga taaaatcaca agcatatctg 1856761 catcaatcaa tcctgcgact tttgctgcga gcgtatcatt gtcgccaaac ttgagccgat 1856821 tgacggtaac tgtgtcattt tcgtttatga tcgggatgat gccgcgctcg agcagtacat 1856881 tcattgtatt cctgacattg ttgtatcgat attcatcaga aaaatcgctt ctcgtaatta 1856941 aaatttggga tgcgacatag ccgtgtgcca aaaacagctt tgaataagcc tccattagca 1857001 atccctggcc gattgaagct gatgcttgtt tttctggaag cttctcgggc ctttggataa 1857061 atccgagctt ccgatatccc gccgccactg cgcctgagga aaccaaaatc acttcataac 1857121 cggcgtcttt gagtttgacg acctggtcga ccaacgcttc taattttcga atgctgattt 1857181 ctccatgaag gcttgttaat gaactgcttc caatcttcac aacgactctt ttcatgcttg 1857241 tatcaggcgt cactttatca ctcctgatag cggcgctgca gttttttcga tatcttcgct 1857301 gatttccttt gaacgcttag ccgcatgctt tattgcttga gaaatcgctt ctccgccgcc 1857361 gctctttttc aaggcttgca gccccgctgc tgtcgttccg ttcggtgacg tgatattatc 1857421 tcttaagatc tcaggatgtt ctcctgtttc catgagcatt tttgcggcac ctaaaagtgt 1857481 ctgtgcgccg atgcttcgag ataactgttt atcgaggccc gcttcctcgc ctgtcttttc 1857541 aatgaattcc attaaataat aaaaatacgc gggtccgctg cctgcaattc cggtgaatat 1857601 atccatttga ttttcttgga ttgtatagac ttcgcccatg catccgagca atgcttcggc 1857661 cagcttcttc aggtcttccg acacatattt gccaagggca atagctgttg cagaagcgcc 1857721 aatcatactg gaagtgttgg gcatcactct gacaaccggc tgttcattaa gcaatgattg 1857781 ttcaataaaa gaggtagtta tgccggcaag gaccgacaat attaattgat ggggttgaat 1857841 acgtgatttt agtgatgaca gagcgttttc ggcgtctttt ggcttcattg ccaaaatgag 1857901 cacatccatg tcttcaatac atagttggtt cggcaaggcg cctttaatgc catattgaag 1857961 ttcaagttca gttaatcgct ctgtattgct gcggtttgta acgcagatgt tttgtttcgg 1858021 gattttgttg gctcgaacga tacctgatat cattccttcc gccatagatc ctgctcctat 1858081 aaaggctact ttcttttgat caaagatcgg taacatctcc tttgttcgct tttttgttcg 1858141 cattttcaca cgtttaaaat gttaccacgt gaggaaatga tgtcaagttt gaaggccatt 1858201 attgatttgt attgtttctt ttcgacaaat atgtataatg aaaagcagaa aacacccggt 1858261 tcacactgct gcgccgggtg tttgtttcta ttaaaaatta tctgagagag ctttttcaat 1858321 cagtttttta cagcgatcca gctctacctt cagctgtttt ttatatagct tggcagcttc 1858381 gtaatcttta aattgataga ggacgacttc ctggagctta gccccttctt tttttacttt 1858441 aatttgtttt agtatcccgt catcaagaag ctcatgcaaa gaccggtata cttctgtatg 1858501 atttggttta aaaccaatct ctttaaattc agaccgaagt acttcaagca gctttaaccc 1858561 atagagtctc tcttgctctg tcatcgttat catataaagc ttcaaaaatg cgcgctgttt 1858621 cactaaaaag cctgttgaac tccttttttc ttctttcatc atatgcactc cttcttctgt 1858681 cactgacaac actatgtact aaatattcaa ttttctttta ttgttttcct tctttatatt 1858741 aaagactgat agtccagtta tttcatgttt actgattata ggtgtagcgg aaaaaataaa 1858801 tttcgactga acatttggta catagttttc ttagttctat tatagcctgc atttactgct 1858861 atcttcaatt taaacgattg ccagggttta catatctcat tttaccggta cggatttcat 1858921 tcaaataaaa aaacctgtcg aaagacaggt tttcattttt aaggatttgt tgaccataat 1858981 cccgctgttt tgatgaaaat acgaggatct aatttcagtt gtgccaccat gtactcagca 1859041 agatcctcag gctgcataac tttttcagga ttaccgtctg ttaagttcaa ttcgatagac 1859101 atatcactag cgacagtgct cggcgttaac gcgctgactc tgatattatg ttttctcact 1859161 tcttgcataa gagactctgt taacccgaga acggcaaatt tagaagcgct gtaagcactt 1859221 gttacagcag ctcctctttg gcccgctgta gatgaaatat taatgatgtc tccggctttg 1859281 cgttcgatca tttccggaag caccgcgcga gtgacatggt acacacccat taggttgact 1859341 tgaataatat tttcccactc atcagctgac agatctaaga aaccgccaaa tttgctgatg 1859401 ccggcattat taatgaggat atcgatatca ccgagctgtt ccttcacttg agctacagct 1859461 tggttaacct gatcggcatc ttttacatct gcagcagcaa atgcagcttt tacaccaagc 1859521 gctttgactt cttcagccac tttttctaca ttagcggaag tccggccaat taacccgata 1859581 ttcacgcctt ctttggcaag cgccagagca gtagcgcggc caattcctct gcctccgcct 1859641 gtgattagtg cagttttatg ttgtaaactt tgcaattgaa gcaccctttc tttgtttaca 1859701 tatgtacgat atcacattat aagtacaata catccaatac gcaaatcaaa cgaactgtgt 1859761 aaatatcatt tcttctgatt aaaaaaacgg atacagggta atgacataag aaaaggagtg 1859821 aacatatgat tatagtttat atcagtcttg cagtattagc agtttctatt atcttcttag 1859881 gagttaccgt gatccaaaac aagaaaaaaa tagaccccgc actaaaggag ctttcctctg 1859941 ttacgcaggc tatgcaaaaa caaatcgaag gattaaaaac agaaacagag ctgctgacgc 1860001 aaaaacaaaa gaagattcag caggatgtcc aaataaaaaa atacacgctt cagcagaccg 1860061 cagctgaagt gaaagaagtt ccccaagcag tcaaagaggt gtggcaggca ggacatttta 1860121 atagcagata aggatgaatg agatcccgtt gttacgatca gaatggacaa atgggatctc 1860181 atttttcgag gaggcttaca catgattata aaccgcagct gcttaaaaga gttcgcagaa 1860241 aaagtacatt ttcttccctc ttcacttaca aagtccgatt tacttactga tccatttcgt 1860301 ctccatcaag aaaacgaact tggcatctac tattcacctc ataatgaatt tatcaatcgg 1860361 gatgcctcgc ttgtgattgc cgggatcacg cctggttttt cccagatgaa gacagcgtac 1860421 gaaacagccg ccgaaagcct gctgcaaggc gggactcttg agcaaatggc agtagacaca 1860481 aaaatagcag cgggtttctc cggatcgatg agacataacc ttattaccat gctggattta 1860541 tgcgggctgc cgcaagcttt tggcattcaa agcgccgcaa agctttttgg agaattacgg 1860601 catatgctcc atacaacttc cgttattaaa tatcctgtct ttatccagca aaaaaactat 1860661 accggataca aaccggctat cactcattct cctatcctaa gcacttatgc ttttgggcac 1860721 ttccctgcag agcttaacca tgtgacggga ccagctcttc tcattccgtt aggaaaagcg 1860781 gccgaaacag tgtgtgaaac attgatcaga cagcacagcc tccagaattt gatttgcctt 1860841 aacggctttc cccatccatc aggcgcgaac ggccatcgtt tgaaacaatt cagcaaaaac 1860901 aaagagcaac tagaaagaca aattcgttcc tttgctgcat tggttgattt cgctatagaa 1860961 aagaggaaat aaaagggata tgataaacaa aaacacaaac gtggggagtg gttgaatgtt 1861021 tcctatatta gaaacggatc ggcttatact taggcaaatc acagatcagg atgcggaagc 1861081 catttttgct tgtttctcaa acgatgaggt gacacgctat tatgggcttg aaaacatgga 1861141 atctatagaa caggccattt caatgattca aacgtttgct gccctctatc aagaaaaacg 1861201 cggtatacgg tggggaattg aaagacggga cactaaagaa ctgatcggaa caattggctt 1861261 tcacgctctg gcccaaaagc ataggcgcgc ggaaatcggt tatgaaatca tcccggagca 1861321 ttggcgaaac ggatttgcat cagaagtcat ttcaaaggtc gtatcttacg gattttctgc 1861381 ccttggactg tcgcgtattg gcgcagttgt atttaccgat aatgaagcat caaatcgtct 1861441 gcttctaaaa atggggtttc aaaaagaagg cgttttaaga cagtacatgt atcaaaatgg 1861501 gactccatat gatacaaatg tgtactctat tgtgaaacca agagaatgac ggtattctct 1861561 tggtctgtgc cacatccctt ttcctttaaa aagataaaaa gcgcccctca aacagggcgc 1861621 tttctaatta agatgcatat tgaggagatg tttcctcctt aactgctttt tcctcaggta 1861681 tatgaataca ttttgtcaag accgcacttg caaggtaaag ggccgcaaag atccagacga 1861741 caccttgcgc gccgacgaga ccgatgaaca gccaagcgag tgcagggccg acaaacgctg 1861801 ataaacctgc agctaaattc aatacagaca tggctgcccc tttatctttt cctgccaccg 1861861 tcggcacaat tgcaccaatc ggcacatagc ctgccagcaa accgccccaa ataaagccga 1861921 tcacgctgac aaccgctaaa cttccgccgg agaaaacagg tgcgtagtat aataagacgg 1861981 tgaaaatgcc gcagccgact ccgccgaacc aaataacagt atttttccag ccgaatttat 1862041 cgccgacaat accgaagata aggttaaaca caatgttccc caggaaaatc gttccccaaa 1862101 tttgcagcca cacattggtt gaaattccat gctgggccat gtgcatcggc aaaaagactg 1862161 gaaaaccata tgtaccaatg ctgttgatga ttctgatgat tccgcctgta agcacgcgcg 1862221 gatttgtaaa tagaatcgta acccctttta aaagctcctc ggctgtttct gatctttttc 1862281 ttttcttctt ttcaaaacgg tctttattga taaacaatgc aaagaatgca ccgagacata 1862341 cccagaaaat agagctccaa agcgtattca aataaccgaa cgctttgatc gcgtagcttg 1862401 agtaccaagc gccgaacaca aacatgccga ggcaatatgc aatccaaaac cagccgacag 1862461 cagtgctcag tttgctttgc ggtgttctgt aaatgaccca tgtcaagaaa gaataagcaa 1862521 aaagcgggta acctaaccct tttacgaagt aagtcacata catcactggc aggttcagct 1862581 gttcaaatcc aaatacgata aaagcagctg taccgatcac ataaaacaac agccccataa 1862641 acatcgttcg ttttgcgcca aatgcttcga gacatacacc cgaaaaccag gaagctatgg 1862701 caagcgcaat tccgtatata ctaaaaatgg aagcggactg ctgaacggtg agcccgtttt 1862761 cgatcaaaaa aggactgagc cagccttgtt caaggccatc tcccatcata aacaaaacaa 1862821 cccctaaaaa tccccaggca agccgcttcg gtattcctat tttatccaac atatctgtct 1862881 cctccttaga tgctattatt cattaccgta ttaccttatt aaagttgaaa attaaatgat 1862941 tcctcaaaac agcagaaatt ccgtcttaaa ttaatacttt gctttctgat cctgaaaaaa 1863001 agcgctgtgt ttgcttccat tcctcatata aagccaattc tatctgacag tccttcggtt 1863061 cgatcacccg gacatttgct gacatctcct ccgttaattg aaaggtttca ttgcaaatga 1863121 ctgcagcacc gacgacagat gcctgatgat atccctcttg gacatagacc tttttttgaa 1863181 gaagatccgc gatatattga gtgagcgctt tgctttggaa tccccctccg cacacccaaa 1863241 cataatcacg ttcaaacgga gtaacctctg ttaaaatgtc aaagttccat ttgattgaaa 1863301 atgcgatctc ttctagcgct gcacgtacaa aatgtgccct ctttaaatgt gctgacagcg 1863361 gggcatcaaa aagaaaaccg cctctcgtta acgcattctt ttcagccgat aaataagagc 1863421 cgagagccgc tacacatgca tggtcttctt ttgcaagtgc agaaatctcc tcctccatta 1863481 cttcgtacgt ttcattcgga taaaaaatct gttttaattt ttgataattc aagccggtaa 1863541 ttcccggatt cgtttccaca agccaatgcc cttgatccgt atgacagttc aaccaggctt 1863601 tatgttttgt gtcgccatga tcctcagtaa ttttggttat tggcgttgtt gtccctgata 1863661 caatgacaat gtcctcaagt ccagctccgg tgcttttgac agccagctgt gtatccccgc 1863721 cccctgctat aaccttagca tttattgaaa ggcctaattc ggatgcatat tcatttgcta 1863781 tcgttccaat tgctgttccc gctcttacaa gaggcggaag gatagatgga gaaaagccga 1863841 aaatgtcgca catctcttct gaccaagtgt tttgcttcac atcaaatagc agggtttctg 1863901 ttgcctgtga tggttcatat gttaatattc cgctcagttg gtacgtcacc caatcactga 1863961 tgcttgtaaa gcttgcagtc ttttcccata aagagggctg gcgctgtttt aatccataaa 1864021 gcttgagcgc agaaaaaagt gcagttggca ggcggcctgt gctgctgtat atctcttccc 1864081 aatcgggaat gcccgcctcc cactctcggc cgcgattatc gatgttcggc agcccgagaa 1864141 aaggattgcc gttttgatca atcaaaacaa tcccctgtct ttggctcgtc gatgtcaaac 1864201 caatgatgtc aatatcacac gaacgggata gcgcacgttt tgccaaattc atcacctgct 1864261 tccacagcac ctgaggagaa aaataacggc tgtccgggta aagcgtctct gtggaatact 1864321 cgatgtcctc ccgttcaact gttagaacac tgccagttac actcacgacc gctaccctcg 1864381 cattgcctgt gccaatatca aaaacgagat agcctttttg ttttttcatt ctgttagcct 1864441 cctttcttat ccccctgttt tcagtgcgtc cttgttatac attgtctgaa tattaagagt 1864501 tttttcaccc ttccactttt tgagggcttt attcagtatc gtcacgtgat gatcctccac 1864561 ttcaaatgtt gctccagcga gatgcggtgt tgccagaaca ttaggcaatg aaatcaattc 1864621 ataatctgat tcctctggag gttcatgata aaaaacgtct agtatcgcac cgctgatttt 1864681 atgttctttt aatacaaata aaagatcttc acggtttaca acaactgctc ttgaagtatt 1864741 aacgaaaatc gcactctctt tcatcagatc aaaatattgc cgatctatca gtccgagtgt 1864801 ttcctcagtg cgaggcagat ggacagaaac gatatcgctg tctgaaaaca ccgttttaag 1864861 agatgctttt tcatacaacg gatgatcgtc ttgaatgtat ggatcgtaat attttatctt 1864921 acagtcaaac gcagtcagca gttttgcaat cctttgcccg actgcgccga acccaatcat 1864981 gccaaccgtt tttcctgtta gctcatttcc tttaaatttg acataagcct gcaggtaatc 1865041 actgtcccac tctccatcct tcagccactg attcgaggcg ctggtatggc gcagaaagga 1865101 aatcacattt ccaataaaca tttcggcaac ggcttgtgca ttccgccctg gtgtataaaa 1865161 aacaggtatg cccctttttg aggcagctgc cacatccaca tttgagggca ttcccctgca 1865221 aacaccgaca aatgaaagtt cgggaacaga agcaaatacg ctgtctgtta cctgatcaag 1865281 ttcagtaatc aagcctgtcg catttgttgc ttttagcagc tgaatgagtt catcctcccg 1865341 atatgcccta ccttgttcct tccaagattg ataagcaact gagccaaaca agttttcaag 1865401 ctcttttcgt ccttcttcgt tgtacggtgc tgtaaccaaa accgtcatgc tgcaaaacat 1865461 ccttttcatc gtatttttca taaaaaaaat ctctttccga agatggaaag agattcatat 1865521 ataggcgcgc tctgttacag gcagacgccg gtataaacct tgctttccta tctttcaagc 1865581 tagcgcttgc tggaattggc acaataatgt tgccgaggtt tcatagggcc agtccctcca 1865641 cctctctgga tagaaaatat tgagtatgta attttcagaa tgaagaatac gtttatcata 1865701 aagaagactc agattgatgt caatctcttt ttttcagaat tgacgttatc atcggaaatg 1865761 ttataattct tacaaaatat ctaactagag agaggaactg ggccatgaga tcttttgcca 1865821 cacaacaaaa cggcattttc aaatccgttt gctcgctgga ctgcccggat cagtgcggat 1865881 tgttaataca taaaaaagac gggaaaatcg taaaagtgca aggagaccct gatcatcctg 1865941 tcacagctgg aaacatatgc aacaaagtcc ggaatatgac ggagcgcatc tatgatgaaa 1866001 agcggctgac tacaccgctc aaacgaacag gtgcgaaagg ccaagcgata tttgaaccga 1866061 tttcctggaa agaggcaatc gatacgatca cctcccgctg gaaacagctg attgatgaag 1866121 agggagctga aagcatactt ccttacagct tttacggaaa tatggggaaa ttgacagctg 1866181 aaggaatgga ccgccgcttt ttttaccgca tggggtcaag ccagcttgaa cggacgattt 1866241 gcagcaaagc gggatctgaa ggctataaat atacaatggg cataagcgcg ggaatcgatc 1866301 ctgaggaaac cgttcataca aaactattta ttttttgggg aatcaacgcg gtcagcacaa 1866361 atatgcacca aattacgatc gcccaaaaag cgcgaaaaaa aggtgccaaa attgtcgtga 1866421 tcgatgtgca taaaaatcaa acaggacgtc ttgcagattg gtttatccca ataaaaccgg 1866481 gaaccgacag tgcacttgct cttggcatca tgcacatttt atttaaagaa aaccttcatg 1866541 atgaagcatt tctgtccgag tacacggttg gctatgaaga gctccgtgaa cacgtgaaac 1866601 aatatgatcc tgaaaaggta tcgacgatca ccggtgtcag taccgaagat atttaccgac 1866661 tggcaaaaat gtacggggaa acctcccctt cttttatcag aatcggaaac ggaccccagc 1866721 atcacgataa cggggggatg attgtaagga cgattgcctg tcttccggcg atcaccggcc 1866781 aatggctgca cacagggggc ggcgcaatta agcataacag cggaatttta gaatataaca 1866841 caaatgcctt gcagcggccc gacttattga aagggcgcac cccgaggtcg tttaatatga 1866901 atcagcttgg cagggtgctt ttggaaacag acccgccgat tcgctctcta tttatttacg 1866961 gaacgaaccc tgccgtcgtc gcgcccgaag caaacaaagt cagacagggc ttgctgcggg 1867021 aagacttgtt tactgtggtt catgatttgt ttttaacgga aacggctgca tatgcggaca 1867081 ttgtactgcc tgcaacatcc gcttttgaaa atactgattt ttacacctcc tactggcacc 1867141 attacattca gcttcagcag ccggtgattg agagatatgg ggaaagcaag tctaacactg 1867201 aggttttccg attactggct gaagccatgg gattcacaga ccaggagctt aaagattcag 1867261 atgaagtatt aatccgccag gcgcttgacc atccagataa tccgcatttg gcagagattg 1867321 attacgattc acttactaag cattcattta tgaaagcgaa acgtgaaaag ccgctgtttc 1867381 cgggcgaact tccaacgcca agcggaaaaa tagaattata ttcagaaaaa atgaaacaag 1867441 acggcttccc tgctttaccg acatatacac ctcttgtaac cgataatgaa catccgttta 1867501 tgtatgttcc ggggccaaac cataatttct taaactcaac attttccaat aatgaaaaac 1867561 acatcaagct tgaaaagacg ccaaagctct ttatcaacac aaaagatgct gaaaaacacg 1867621 gaatcgttga tggggcacct gtacgaattt ggaacagccg gggagaatgc gagctgaccg 1867681 ctgcagttgg agaacaagtg ctgccaggtg tcgttgtcag ccaaggatta tgggcggatg 1867741 aacaaggaaa aaaacagctt gtaaacgcgc taaccccaga tcgcttgtcc gatatgggcg 1867801 gcggcgccac ctttttttca ggccgtgtac agattgaaaa ggtttgaaaa ataatgaaac 1867861 ccggagtatg ccaagcccgt ataacataac atcgacataa tggaggcata cacatggacg 1867921 tttttttagg aattggtatt gctttggctg gatattttat cggtgaaggc ttaaagcaga 1867981 ggaaccaaac caaaggtaat gaacaaaatg atatcttcct aataaaagaa cgggatattt 1868041 acttttacat tggacttttt ttaggaataa caacgactga agcaaaacag ttagctggag 1868101 acatggcaga cctgccttac atcgaaataa acggaaaaaa atatgtccag aaacatatgt 1868161 taaaagattg gacattcaca ttagttgaaa aacatcaggg tgaataaaac aaatctgagg 1868221 agagcgagat tcattgtcac gctctcctct gtttagctgt atggatcctg ccaccaaaac 1868281 tttgtgctat aagcgctgat aaaacgataa accaccatct atgttctttc ctcaaacaac 1868341 tcaagatgcc cgttccacaa caatagtttt tatattcctt tgatgacgtg atgttcttga 1868401 tgaacgtatg tatcgtaaaa cacttagaaa acctattcgg tttgaatgtg tgctctcatt 1868461 atgcccccat actgcgcctt tatccgcgga ggattttttt aaaaaaatat gaaacctaaa 1868521 gcttttagat cctgaatttt tattgaacct ccatatttct ccgattggta aaaattagcc 1868581 tatacaccgg aagctgtacg tttataaagg atcagagaat cccataacca gtaaatcact 1868641 gcagccgcaa tacttaacat ataataaaag tacgattgca atgtccatgc tattgacgca 1868701 ggttcattga taacaaaaaa caggaaagct gcgataaaag caaccacact gtaaatcaat 1868761 aggtacatga cattgaaagt tctcgctttt ttctgcaact tcatttggag cggaacagca 1868821 aaaaggccat acaccacaaa accgtataat aaagcaattg ctgccgtaaa caatgcaatt 1868881 atcatatcgc catacataac gaaagaataa aaccctaata acaaaccaaa tgtaaggctg 1868941 gatagcccta atgtcattaa ataatatgat gcgatttttt tcattttttc accccccttg 1869001 tttgatttat tcacagtgct gttagtataa attcacaacc tttgtatttc ttttatcgag 1869061 atgtcttccc taacgtgcta tacgcaatgc gctaataaaa ggtttcaaaa atgacgttct 1869121 tttattagat aatacgctgg ctgaaaacgc ctctcctgat tggccaaagc gcgaatgaaa 1869181 aaagtgcatg aatacctgcc caacagacag aataagaaga gttgatattt caacactttt 1869241 cgtaaagggg tgaaaccaat gagtaagaaa ggtattcaaa attcaagtat tgaacaaata 1869301 agaaatgacc atgagactga aacagctttt aaagcagatg atcctaaaaa acacggttcc 1869361 gatcctaaaa gaacgaaata agttcttacc cccactaaaa tatcaataat ctggaggaag 1869421 taaagtgact caaaaaaacg gtgcagacag acctgatgat tataaaagat tttcttcatt 1869481 agacaaggaa tatgattttc agcaatctat acgcagcaat actgagacag aaagtgtaaa 1869541 cactgaaaca caaactcata acaaagaaaa caaaaatgac acaacagatg ttgccgggaa 1869601 atactttgag ccctcagatt ataaaggaag cacgcaatta gaaaaaggat tggctgaaac 1869661 tcatgaacag gtcagcgatg actattttga agggacaatc gatcaaaatt tggactagcc 1869721 atacaaacgg aactaactta aaagaagtca gttaactctg tttttagaaa caaccacagt 1869781 aaaagtagcc aacccccacc gaataagatg ggggttgcac gtaagtagcc tgtttaatat 1869841 ttaaaacgat taatgacggt ttgaagttct tctgccaact gagatagaga ttctgcggca 1869901 taggagattt cccccattga atgaagctgt tcctgtgatg aatttgcaac cgcttctgta 1869961 tttgctgacg tttcttttgt accagcagcc aatgtatgaa ctgtgtgctg aatcacttca 1870021 acgcctgaag taagctgttg agttgctgct gcaacttctt gtatttgaga agtgacctgt 1870081 tccaccaggt tcagtatttc attgaaattt cctgttgtct cttgagaaag aacaatacct 1870141 gagctcacat tttcttgaac aactttaata ttatttaccg tttctatcga ttcgttttgg 1870201 atggtcgcta ccaccgattg gatgtggttt gcagatttat ttgtttcatc cgccaacttc 1870261 cgaacttctt ctgccaccac agcaaatcct tttccttgct ctccggctct ggccgcctcg 1870321 atcgctgcat ttagtgccaa caaatttgtc tgctctgaaa tcgtcgtgat aagcgaagag 1870381 atatcgctga tttctgctgt gctcgctacc aatgtttgca atccattgcc ggctgaatct 1870441 acagatttat caatgaattt catctggtct aacatcttgt tgacggactt agagcctatt 1870501 tcagccttgt ctctcatcga agaagaaaga tccgctatgt tccctgtatt tgaagcgact 1870561 gatgatatac tgtctaataa ttcagtgatg gattctgcgc tcttttctgt cattgagctt 1870621 tgcttcacat tgctgtcggc agccatctgc atggctcgtg aaatatgttc agatgttgat 1870681 ttcgattctt ccgcgcttgc cgataattct tcagaggaag cggcgacttg ttcagatgag 1870741 ctgctgatct gcttcacaat ttgagttaat gaatgagtaa aagaattaaa agattgggca 1870801 agctggccaa attcatcttt atttttcaca atgacttttt tggttaaatc agcctcgccg 1870861 tgtgcaattt cctccagctg cttatttatg cttcttagtg gcaccataat ggactttaac 1870921 agcattatgc ttagaacaat gcctaatatt actgatatcc ctgtgacaat gataatgagc 1870981 gattgactca ttttcccatt gccctgtatt tcatccttta gatcctctac ctcttgatcc 1871041 aggcgatcag acagcttatt gacagccgga gctacgcctt cttttcttat tgttctttct 1871101 tctccaaaat ggatggtttc tgctttttta ggatttgaag agtaggctgt tactacttgc 1871161 tgattcaaag ctctatactg agtaaaactt gtcttaatgt cttcaatatt ggattgatac 1871221 ttctcttcat caatcaagtc attaacccgg tcaaggctct ttaagacatc gtctgctttt 1871281 cccttcatac cctcgtcgta ttctttgtct ctggtaatca agaagcctct ttcatcattt 1871341 gataacccgg tcaattcata ttggatgtgt tttatctctt tttggaattc cattttgtct 1871401 ttaagttctt cattcttttt cacagtagaa gaaatcataa atactgagga gcctccaatt 1871461 ccaataattg aaacaactaa tattgatata atccccagca attttgtttt cactttcatg 1871521 tgtcgttttc cctttccgca caatgtaatg gctgaaataa aatatgttca agcgcgtttg 1871581 aatccaattc gcttacgctc atgtccataa tatcgacacg tgttatcaag ttttatagtg 1871641 atattcttat atgaataagc aaattcttta cgtctctgaa cttacagaaa aaccttaagt 1871701 aaaatttgca gtcttttgcg gtatgtaagt cactcttatt cgtttttcta aaaaaggctt 1871761 ttcccacctc aaattggctg aaccggctgt tttctcgaaa atataataca atacgcagca 1871821 taatatgaag gagcgaaact taaatgggga tcatcaatgg taaagaattc attgaccgat 1871881 tgaataaact agaaaacgaa atatggtatg atggcgaaaa aataaagggt aacatttctg 1871941 agcatcctgc atttaaagga ataatcaaaa caaaaagctc actttatgaa ttgcaaacaa 1872001 aggatgagtt aatacatgaa atgacttatt gccttcctgg agatcataat cgaatcggcc 1872061 tttcctatct ccagcctaaa acaaaaaatg atttgaaaaa aagaaggacc atgattgaac 1872121 attgggctag acatactcat ggaatgatgg ggagaagtcc ggattacatg aatacggtta 1872181 tgatgagctt tgcttcgtca gcggagcttc taaaagataa agagaattgc tttcctgaac 1872241 atatactaga tatgtatgaa caagctgcta agcatgacct ttcctttacc catacattca 1872301 ttactccgca agtgaaccgg tcacagtcct attttgggct aagtgaaaaa ccgatatctg 1872361 ctaaagtcat tgatagaacc gaaaaaggtt taatgattca tggcgcacga ctgcttgcca 1872421 cacaaggcgg gttgaccgat gaaatcttgg ttttttcagc gcctaaattt ttctttgaaa 1872481 cagatgaagc ttatgctttt tcaatccctt ctaatacaaa aggcgtaaaa ttcatcacaa 1872541 gagaatcatt tgtattaagc gactcttcct ttaatcatcc cttaagctca aggtatgaag 1872601 aaatggattc aattgtggtt tttgatcatg tgttagtgcc gtggaatcgt gtgttttttt 1872661 acgataatgt ggaagcagct aaagatttta tgacaaaaag ctcttttcat gcctttacct 1872721 ttcaccaggt tgtcattagg caaatgataa aaattgaatt tctattaggt gttgcacagc 1872781 ttcttgtcga caccattaat gtttccgaat atcagcacat ccaagaaaag ctctcagaaa 1872841 tcattgtggg attggaaaca atcaaagccc tcattgacaa atcggaaaat gatgctcagt 1872901 tagatgaatt cggctatatg cgcccctgtt taattcctct tcaagtcatc agtacgatca 1872961 ttcctaagct atatcctcga tttactgaaa tcatacaatt aattggagct agcggaatgg 1873021 tgacactgcc taccgaaaat gcatttgact cagagatacg ggaagatctt gaccaatatc 1873081 ttcaagcaac caatacaaat gctgaagaac gtgtgaaaat tttccgtttg gcatgggatt 1873141 taacaatgag ttcattcgga actagacaaa ctcactacga aagatatttt ttcggagatc 1873201 ctattcggat ttcaagcagg ctgtatacca gttatccaaa gcaggagcag ttgaacatga 1873261 ttaaaacatt tttacatgca gatacagaac attgaaaaaa cagcgggaaa agatccgctg 1873321 tttcgtattt tttattcagg aaactgaaca tggcccggta ctgtataggc tttggacgtt 1873381 ccgctttcag gcagctttgg aatggtgtct ttcacaactt ttccgcggat gtcagtcatt 1873441 ctgactttga gagagccagt acctaaattc gtactcacaa aatggttata gtccattttc 1873501 tccatgttga tccacttacc atccttttca tattccattt tcataacagg atacttgtga 1873561 tttctgactt ggattgctgc ccaccacctg ctgctgcctt ctttgatccg gtacgtgaaa 1873621 ttgccggtga ttggggcttt gacaacacgc catttaatat tgatttttcc gtctttcata 1873681 ttgccgattt tacggaaggc attaggtgac agatcaagag ctccccgagc gccttcggga 1873741 taaagatcag taacatatac ggttgttttc ccttttggcc cttcaacttc caaataagag 1873801 ccggcaagtg ccgcttttac tcctccgtaa ttgagatccg ccggatttat tgcagtaatc 1873861 tccatatcgg aaggaatggg atccagcagg aaagctcctc ctgaatagcc tgaccctgta 1873921 tacgttgcat aaccttcatg caggtcgtca tatgctgccg aagcttgcgg ggaaaaacag 1873981 aagatcgtca acaaaaccat accaacaaat gcactcatga tctttttcat atttggtcct 1874041 cctcaaacca gacttcaaat gagaatcatt atcattataa gactcaatcc atctggtttg 1874101 aaagaggaaa tagattcata gttgatttta aggcaaattc actatcattc atatatcaaa 1874161 tgtaggtact tatgaaaaag ccaatacaaa tgaacgaatg tgcacttcag ccgaatgtct 1874221 tatttttccc tctcaaaatt cgcatttcaa taacgaaatg aaacaggctg ttggcctgat 1874281 aacagctata caggaaaagc tatttttccc cgctcagttt caacttagct gtcatcatga 1874341 tgccaaagat cagcacaatc ggaacccaaa taatgaagtg ataaaaatca ggctcagcca 1874401 gagcaacaat aatagcccct acacaataca aaataatagc cagtgctctt aacacagtat 1874461 ctcttaagaa agtcttcttt tgcttcttaa aaaacaaacg gccggatata tcctctaaaa 1874521 gagaagccaa agtgccggtc aacacagttg aagaaatacc tgcaatcccc agtttttttg 1874581 ctgctgtagt ttgaatcccc atagaaatgc tcatgagtat aattagaatg tgcacaggaa 1874641 caaatgcccg gtaaaaagaa agacaagcaa agacaaacaa aatgaatgct tcaagtgcga 1874701 gggcttttgt cacagcagaa ggccaaaggg tattttccgc ctttccgacc atcaatgtag 1874761 caatgatcac gccgcatata aatccgatta gcgcagtcaa ggaattaaaa acagtgacct 1874821 gaatggattt gccgatagct aaccccaata atacaatgtt tccagtcata ttagctgtga 1874881 acacatgtcc caggcttaaa tacccgatta catccacgat tccagctgtt aaacataaaa 1874941 gtgatagcaa ggtgtttcga taagctgctg cagtcaacgg tgtatcaatc ctttcttcta 1875001 tttcaattgt tagtatgtct tttggcgcaa tctctatttt ttaagtaacc caacattaat 1875061 taggaagata gaacctatta ttcctttcca ttaactgtaa taataatccc cgcaaggaaa 1875121 tgattaaaat tgaaaggaag catattgtga tgaaacgact ttgtttatgg ttcaccgtct 1875181 ttagcttgtt tttggttctc ttgcctggaa aagcattagg tgcagtcgat tttccgaata 1875241 cctcaacaaa tggcctttta ggttttgccg gaaatgccaa aaatgaaaaa ggcatctcta 1875301 aaacgggcac aacgggtgga aaaaacgggc agattgttta cattcaaagc gtaaatgatt 1875361 taaaaaccca tctaggagga tccactccga aaattttagt gcttcaaaat gatctttccg 1875421 catctgcgaa aacaacagtt accattggct caaataaaac actcgtgggc tcttacgcga 1875481 aaaaaacgct gaaaaatatt tatttaacaa cttcatcagc ttttggaaat gtcatttttc 1875541 aaaatttaac gtttgaacac agtccgcaga ttaacggaaa taatgatatc cagctttatt 1875601 tagattccgg tatgaactat tggattgatc acgtcacatt ctcaggtcat agctataatg 1875661 caagcggaag cgatttggac aaactcgtgt atatcggaaa atccgcagat tatatcacga 1875721 tcagcaactc aaaatttgcg aatcataaat acggtttgat tttaggatac ccggatgatt 1875781 ctcagcatca atatgacggc tacccccaca tgacaatcgc caataattat tttgagaact 1875841 tgtatgttag aggcccaggt ctgatgagat acggttactt tcatgttaaa aacaattaca 1875901 gcaataattt taaccaggcg attacaattg ctacaaaagc aaaaatatat tccgaatata 1875961 attactttgg gaaaggcagt gaaaaaggcg gcatccttga cgacaagggc actggttatt 1876021 tcaaagacat aggcagctat ccatcactca acaagcaaac ctctccgctg acttcttgga 1876081 atcctgggtc aaactatagc tatcgtgtcc aaacgccgga atatacaaaa gaatttgtca 1876141 cgaaatatgc cggatcacaa agtacaactc tggtatttgg ctactgatat aaaagaggcc 1876201 ctgcgttaaa aacgctgtgc ctctttttat actataggct atttttaagc gatccttgta 1876261 attccatcaa gatccagcgt cggtcaaact aaaaagcata tgttcttttc cacaataact 1876321 tcttaactgg ctttcttatt ataccagttt atcgcaagtg aaaagaaatc attgttctga 1876381 acctgtatta aatgaacgat cgtcccacaa actacttaaa aacccctaaa aaggatgatg 1876441 gatatgtgcg gcaggtttac tttgtactct gcatttgatg atattattga ccagtttgac 1876501 atcgatcaat tttttcctaa aggtgaatac cagccaagct ataatgtcgc accatcacaa 1876561 aacatccttg caatcatcaa tgatggatca aataatcgct taggcaagct tagatgggga 1876621 cttattccac cttgggcaaa agatgaaaag atcggttata aaatgatcaa tgctcgagcc 1876681 gaaacaatta ccgagaaacc ggcctttcga agaccgcttg tcagcaaacg ctgcatcata 1876741 ccagcagaca gtttttatga atggaaacgg cttgattcca aaaccaaaat cccaatgcgg 1876801 atcaaattga aatcatctgc tctttttgcg tttgctggct tatatgaaaa gtggagcaca 1876861 catcaaggat accctcttta tacctgcacc atcataacaa ctgagcctaa tgagttcatg 1876921 aaagatatac acgaccgaat gccggttata ttggcccatg atcatgaaaa ggagtggctt 1876981 aaccccaaaa atacaagccc tgattatctg caaagtttgc tgctgcctta tgatgctgat 1877041 gacatggaag cataccaggt ttcatcatta gtaaattcac ccaaaaataa ttcagctgag 1877101 cttcttgatg cagaaaatca tatgtagtga ttgaaaaaat tctctagcaa gaacttgtca 1877161 aatagctttg ttccttaggt gccaatccct ctagtaatta tgaatattta gtacatagat 1877221 caattagtta tctttagcat cagtttgaaa taattttatt atgtaaactt aaataagcaa 1877281 tgttattcct ttcatataaa atagtttaca tttttataaa atcgcttcac ttttctattt 1877341 tgtcagcaaa aaaactgaac cacattaaac ttatgaaacc tgccgcacct gtggattgca 1877401 aatatgatat aagcccatag aggtaaatcc atacactttc cctcctaaga attaaatgaa 1877461 atttctttca tcttacatga aggtcttctt tcttttgttt atccagtgta atacttaata 1877521 atatgttgat gaatgcagct ggaaaatata taaatcccac tccaagaatg cctagtatcg 1877581 tacttaaact tactatgtaa ttctttgtca tcgtttgact gtcaatcaat attagaagtg 1877641 aaatcaatcc agctaaaaca cctataaacc aagcatcgcc aacagcataa gaatcatcca 1877701 gcatccctaa ccatcgcccc aatatagagc tcccaatggc agtcaaactg gataaaaata 1877761 tgagtgcttt catttcttct cctcctttaa agccaatcaa actggtagaa atcggccatt 1877821 gaatccccat tatcgaatgg ttaccatttc atttccacat taacatttta aagctcatta 1877881 caatacgatt caagcagaaa aaccctacat aacgtatata tagggattta ataaaacaca 1877941 ggccaaaatt cagctctatc tactttaaaa agatatgaag ggcagctgtg tgatctgtta 1878001 cgtctttacg taccgggata tttcacaaca ggcactttct tcttgcgcag agaatcaagc 1878061 atgactgatc cagcattcaa gttgctttgt actaattctt taggcgtcaa tgccatccac 1878121 tgattgagtg acacatctgc atagcggtta cttttgaaca tttctaaaaa ccataatgtt 1878181 tctgtaccag tgttttgtat atagtgtccg gcattagaag gcacgtatcc aacgtcgcct 1878241 gctctataat caaatgtgcg ggcagtccca tttccgataa ataccgtcat tcgtccctgt 1878301 cctgttagat aatattgcca ctcatcgcta ttgggatgcc aatgaagctc tctcatcgcg 1878361 ccaggctcaa tctgaacaag tgcagcggct atcgtttttg aaattgggaa gttagaagaa 1878421 tccacaattc gtacactccc ccctggcatt tgaattgggg gttgatttaa cagctcgtgt 1878481 ttaaaggtca tggggacttt tccatatggt gactgaatgt cttcactggc gactgatccc 1878541 ggcacattcc cttggtagat atagacttgc tcagacggaa gagagttgaa agcattctcc 1878601 gggacaccga aatttgcaga cagaacatct tttggtgtgt gtgcaagcca atctgaaatg 1878661 gttaacgttg aaaactcaga aaagttccca tcatcgaaaa cgagcagaaa ctcgcagtgt 1878721 tccaatccct gtatggaatg cggaattcct gccgggaagt accaaaggtc gccgggacca 1878781 acatcagcaa tgaaatttcg tccgtcttgg tcaacagcgg tgatacgtgc ccgtcccaaa 1878841 agcatataag cccactccgc ttgcttatgc caatgaagct cgcggacgcc tcccgcagtt 1878901 aagctcatgt ttacacctgc aatcgcagtc gaaatcggaa gctgtcttac ggtgatttct 1878961 cttgaccagc cgccgtgatc taatttcatg ggagcgtctg agaatgaaaa tctcaagtta 1879021 ggaatcatac cctcatctgt aacaggcgga acaaatatat tcggattttg aatatcccgt 1879081 attatatttc gcgggcctgt atcaatagct ccagctccat cacttcgaat aggctgcggc 1879141 acgtttctgt cttcatgatt gattggttgt tgttccaaca gcatgcacct cgttttagaa 1879201 atgaacaaga ttttatttca gcctatgcag aatcttagat tgctgtgcct aggaatccgc 1879261 aaataaaaaa gtgaccacca atgtgatcac aaatacatca aataaactat tttttatacc 1879321 atggcttctt atgtaatttg attgcttctg tctgtttttt ctggcctgtc ctccactcca 1879381 cttttactaa tacatcatga cctatcactt catcttcagg catataatca aaggtggaaa 1879441 tatggtcctc catgcgtccc ccacccggca tttcatcacc tgtgtactcc gataagtcgt 1879501 actcatctac gttatcatct tgatactttt cgccatctac atacagagta attctttcaa 1879561 caacagtcca cttttcttcc ttcttactcc cctgccaata tagatttaga aaataattgg 1879621 gtccaattga agttttgtct gatttttcaa ggttagacat ccacagtccg cttttcccgc 1879681 tgccctcata tttcactttg ttccctgaca ccattacaaa taatgtgatg atgcagatga 1879741 tcaagaatcc agcaatgatc aatagccatt tcttaatatt gttctttttt ctcatgtttt 1879801 tcctcacttt cctaactttt tagtaggaaa atacgatcaa aatgttaccg aaaagaaaat 1879861 aagaaagggc taatgatcta acagatgact gtctaaactt ttgacttaaa ttaaagtgct 1879921 ttctaaagac aagattaaaa cgtataacag ctcttaaatg cattttttgt ttcattgagt 1879981 caagaacctt aaaatggctt tttattatta aaaatcaagc tagtgtatta agtaactttt 1880041 caaatttatt tatactcatg atctcgtgag tcacaaatct cccatcaaaa aaaacgctaa 1880101 aagttgtcca aatagctggt gacttttgtg cctcttcttt cgatgataac tgaattgact 1880161 gaaattgaac ccctttcttt tcagtcaatt cccgcaaatc atttatcatg cccactgcaa 1880221 acggacactg agctgtatag tatatcgtaa tccccttttc attgatagaa tcacttttca 1880281 cctggctctt aaatgcagga gaatctgcaa ggccattcca agtcaaagcc attaattgaa 1880341 aataaggggc agcttcatct tgtagagtaa accccatatg ctcaaagaaa tgcttatcac 1880401 ttaaataggg cagttttttc ttgcctgcga tatggataat gccatccatg ccgcacgctt 1880461 tcgcatctgc tatacatttg tccaacaatc gtttcgcatg accgttattt ttatatctgc 1880521 cagacaccca cagacaatta atgtacataa aattaggcgc attgataggc acccatgcct 1880581 cattcgcagg taggtattca ataaagactt ttgcccgttc atgtaagcga tagaacacca 1880641 atccttcatc cattcgagct ttgagccatc tcttcttttc attaactgca tgctcatatt 1880701 gtttcgtgct taatgcacag caaatatgat tgtcttcaat attgtccttt gtgatttcaa 1880761 tgtagcacat ctcctctttc ccccctttaa cataattaca tggaattcaa cttcacactt 1880821 tacatgccta atagaataaa tacccgttcc aacttaaata ctttttcttt tccattttgc 1880881 caattaactg taaaaccctt cttttattca gatattatct tgattcctat atcacccatt 1880941 tcaaatccaa agtgtgttca tctttgagga ttagatgcac tgcttatgct ataaatacag 1881001 tacacgaagt tttttatttg aagtaatatt tgttacggga cagcaatagt aaataagtga 1881061 taaaagggga attaaacttg gtggaaaaat gttattcttg tttaatttgc ggatacaaag 1881121 gattaattca aaatcctttg tataaaggcg agtatcaaaa aacgtttgac atttgtccat 1881181 gttgcggttt tgaatttggc tacagtgagg atcatgatgt gaggttaggt tttattgtaa 1881241 ctcctgatca tttaattgag gctgcatttc aattgtatcg caaacaatgg cttgagagcg 1881301 ggatggtaat tgctcatccg gaagatattc cagaagaatt gaaaaatggc aattgcttaa 1881361 aatttgaagt tttgttgaaa caattgaaaa aactaaatct tgacatagaa aattttgaaa 1881421 ttagcggttt ttaatgatga aacaggttgc acttgtttag gtttcactgt cattatcagt 1881481 aaaatgttaa gttgaaatgc gcaatcagtc acaaagtctc tattcgtatt caataaagac 1881541 tttgtgatca tcgacaaaca tttcactccc atcggataaa gtatccaaaa ggcctcctct 1881601 ggttcttctc tatagtcatt aatcacagtc actttgacat ttgactcagc tatgattggt 1881661 tttccaacaa tttttcgttt tttcctcagg caaagtaaga gatcgaatca tcaaagccat 1881721 tccatcttta ctgtctaatt aacgccatct tcagtgaatt taaaggtctg ttttaaattg 1881781 cgtccttctt gccccttctg tgtccaaatt ataacaacct ctaattcaga ggccttatct 1881841 gccagcataa aatgattgaa cttcagcggt gagccatcat ttaaactttc agctaacatt 1881901 ttagaatctt cttttggttt gacacaattt tcatcgggac atccaaaaag cgaaaacctt 1881961 gtgattgaat tagggtcatt tctatacaat tgcacatcca ctgtagctgc tttttcccct 1882021 atatttttga cttccaagga atatacttga tattctcctt tatgaggtct cgtaaattcc 1882081 tttacatttt ttgcttcact tacttttact gaccactggt ctgttttttg tgtaataggc 1882141 aacaccgtaa aagtcagggc atgcgctttt gattggcaaa acgtaaatcc aactgctgta 1882201 aaaacaatta cagaaaataa tacccttttc acttcattta tccctccttc ctttcactgg 1882261 ccgctcctta aagaattgat tttgagcaat ctacaagctc tcttaaccaa aaccttacct 1882321 gaggttttgt ctttactgct ctgcatttat ttctttcggt atccgagaag gagctttggg 1882381 gatttttctc aatctgctgt taatcacatc agaagagtat agcgtaataa tcatacttcc 1882441 cccatacctt tttgcccgaa ttaagattgg ttggttatat tggttttgaa agcgaaagtc 1882501 aggacctccc cagcttaccg tcgcatcccg tccgggcggt acatatggta cacttctagt 1882561 atgagaatag cgctgaacga tctgcagtcc tgcacgatct actgcattaa atagagttga 1882621 ggacacctga caaattcctc ctcctacacc ttcagacaac tcccctttta caataatggg 1882681 tgcactttta tatcctttgt tccgagttct cattcccaca acttggttaa acgaaaacgt 1882741 ctcattaggg aaaacaacgt gattgtcgat tgcttttgca gaaagagaaa tattgtgtga 1882801 acggctttta ttgcttgagt taaaatacgt cacgtactga ccaagctgct gcgtactgat 1882861 gtgagctagc agctcgctgt caactttcgg ataaatgttc atttccggca cttctatctt 1882921 ggagggacct tgcccataaa aatacgcata aaacttttcc ataaacgcct gttgatacag 1882981 tttgtagcca accctgcccg ggacgatgct tccatgatcg ttaaggacag catttatcgg 1883041 ctcacggtac actttctgat caagctgttt gatgaattta ctgtattttt catagtcaac 1883101 cattggagtg ccgggaagag gcattgtaaa gtcttcacgg ttaacagtgg caatcgtccg 1883161 tccttgctgt gtgaccgtta aactgtcctg cggctcactc ggctgagcca ataaaaaaag 1883221 accagtgatc aaaatttgta tcataagtcg gtttacctcc caatcattag tatgaacagc 1883281 cgcttatcct ttgatgtatt tcttcccatc gtttgtttga atctttagac gttgataaaa 1883341 accttcataa aagagcttag ctttatgttc acaccgatcc ctgagctcac tgaggcacac 1883401 ggttcattca gtcggcaagt ttgaagtagt tcagcatctc ccagtgatga gggatgcttt 1883461 tttgtcttgt caaaaatgaa aagggtctcc tataacaaca aaaaatcaat ccatttcaat 1883521 atttttttat tgagaaacga taaatttttt gttacattca attagacaac aaataaatga 1883581 ggtgcttgtt atgaatcgaa tgtcgacaat ttttttaaag atagctttgg ttcttattgg 1883641 aattccaatt cttgctttat gcattttttt agtgcctaag gtagccaact attcagcaga 1883701 attatttcca aatatcgctt atataaaata tctcgttttc atctatttgt atgtaacggc 1883761 gatacctttt tactttgctc tttatcaagc gttcaaactt ttaagctata ttgacaaaaa 1883821 caaagctttc tcgggtttgt ctgtaagagc tttgaagaat ataaaatatt gcgcagtcac 1883881 tatcagtatc ttttacgcag caggcatgcc tgtcttttat ctgatggccg agatagacga 1883941 cgccccgggt atcattgtga tcggattggt tattattttt gcttcaatgg tgattgcggt 1884001 ctttgctgct gttcttcaaa aactgttaaa agaagcgatt gatataaaat cagaaaatga 1884061 cttaacggtc tgaggtgatg acatggcgat tattatcaac attgatgtga tgcttgctaa 1884121 gaggaaaatg agcgtaacag agctttcaga gagagttggc atcaccatgg ctaatctttc 1884181 gatattaaaa aacggaaaag caaaggctat tcgattatca actttagaag cgatttgcaa 1884241 ggctttagaa tgtcagcccg gggatatatt ggaataccga agtgatgaag acacaggatt 1884301 cgtaaagaaa aaatatgaag gatcaacaga aaaataaagt gattggcggt gagcttatgg 1884361 acataaactt atatccatct agctgctata ctaagcgtcc ctttcataca cgaagaacac 1884421 aactatggag gaggcataca tcatgagagc cataaaacaa atcgtccatt ttggctggga 1884481 acaagccctt tcatgtttgt ttcctgccgt tatttttgcc tctttggcta ttacgcaaat 1884541 catcccactg cccttcttgc cgcggtatga ctggctgctc attatctgcg ttctcatgca 1884601 attgtggatg gtgcgttccg gtcttgagac acgggatgaa ttaaaagtga tcacattatt 1884661 ccaccttatt gggcttgctc tggaactttt taaagtccat atgggctcct ggtcttatcc 1884721 agaagaagga tactccaaaa tatttggagt acctttgtat agcggcttta tgtacgcaag 1884781 tgtagccagt tatttgtgcc aggcatggag aaggcttaag gttgaactgg ttaagtggcc 1884841 gtcttttttt gcagttgttc cgcttgccgc agcgatttat ttgaattttt tcacccacca 1884901 tttttctata gacattcgat ggtggttatc agggcttgtc atcattgtct tttggcaaac 1884961 atgggttaca tacgaggtga atggagctcg ttaccgtatg ccgctcgcac tttcttttat 1885021 actcatcgga ttttttatat ggatagcgga aaatatcgct acgttttttg gagcttggaa 1885081 atatccaaac caaatcgata catggagtct cgtacacctt ggaaaggtaa gttcatggct 1885141 cttgctagtg attgttagct ttcttatagt agcatcatta aaacaagtta aggagcagag 1885201 tcccacaaag gcagagatgg atgaatcttt ttcttagcat acgcatacaa gctcccaaat 1885261 agagtgaaaa gcaacgttca aatggttgct tttttctttt atgtaactct gccggtgagt 1885321 attcatcttc ttcaaatttc atcgcaacac gataactgat tcagattaca actgctttca 1885381 acactttgac aaactcatgc gccgccggcg ttatctcttc aaatgaatgt gcgatgacgc 1885441 caatatcgcg tgtgacccta ggaaagatgt cctttttaat caattgatgc gggacggatg 1885501 aaagtgtaaa gtttgaaatg atgccgatac ccaagttatt tttgaccata ttaatcaagg 1885561 tttcggcatt ttgcacagtt aagttttcct ttaattcgat gttgtattgc gaaaatgcgt 1885621 ttgacatcgc gatttcatga ccgcctttac aaaaaatgag gtcatcttga tatgtttcaa 1885681 ggtcgacatg cttttcaagt tttaattcgt cacgctgcgg cgggatgacg gccaccatat 1885741 agtcgttaca caatagctga ttttcaaacg gttcaaatgg agatgctgcg atcccgatat 1885801 caaccgtccg atcttcaacc catcctttta tttggtcaga ggttccttcg atcaattcta 1885861 tgcggatcag cgggtagttt gatctgaatg ccgcaatcgc ctgtggcatg atatttgttg 1885921 aaactgcagg aaatgaacca attttcacct tcccgtttaa cagcttgttt tcccggttgg 1885981 ctacttgata tattttgctt tcaattccct tcatttgcct cgccagcagc aatatttctt 1886041 ttccgatgtc agtcagcatt aaaccatgat gtttatccct gatcaataat ttgagctgca 1886101 gtgagctctc caggtttttt atcgctttac ttaccgccgg ctgagagatg aacaattctt 1886161 ttgccgcttc tgtaatattt aatttctccc caacttttac aaatatgtga agatggttca 1886221 tgttcataac catttggtta tacccccaat aataaaaatg tatttcagtt atacataaat 1886281 gtaacatatg atagaaacca gcacgatatt ttaacaagaa aggcggcttc attatggtaa 1886341 aagttatgct gggaatcata tctgtcacac ttatttgggg ttatacttgg gttgcgatga 1886401 aagtaggaat tcatgacatc cccccgcttt tattttcggg tttgcgcctg ttcatcggag 1886461 cagttccttt atttctcatt ctcttcatcc aaagaaaaaa gctttcaatt caaaaagaac 1886521 atctcaaaag ctatatcatc atgagcctgt tgatggggct gggctatatg gggattttga 1886581 cgtatggaat gcagtttgtc gattcaggga aaacctctgt tttggtatat acaatgccta 1886641 tatttgttac ggtgatcagc catttttcat taaacgagaa aatgaatgtg tataaaacga 1886701 tgggactggt ctgcggcctc ttcggactgt tatttatatt tggaaaggaa atgctcaata 1886761 tcgatcaaag cgctttattt ggggagctgt gcgtacttgt ggcagcgctt agctggggaa 1886821 tcgcgaatgt gttcagcaag ctacaattca agcatatcga tattattcac atgaatgcct 1886881 ggcaccttat gatgggagcc gtcatgttat tggtgttttc ctttatattt gaggcggtcc 1886941 cttcagccga gtggacatat caggcggtgt ggtcattgct gtttaatggc ttgctttcca 1887001 ccggctttac ctttgtcgta tggttttggg tgctcaatca aatccaagcg tcaaaagcat 1887061 ccatggcatt aatgtttgtt cccgtattgg ccctattctt tggatggctg caattgcacg 1887121 aacagatcac catcaatatt atcctcggcg cactgctgat atgctgcggg atttttatga 1887181 atacatttac attttcacga cggaaagtgt gaatgatata catttcccct gtcatttggg 1887241 cttcatgtga caggagaaga ctattacgag aaagtcttct agaatcctga cgacagccta 1887301 ttaaacaatg aaaaaagcta atgtctgcat gtagacatta gcttggctgg cgtttaggct 1887361 ggtgagaatc cagatacttt tttattacca ttctggctga tcaaactgaa aaccgtatag 1887421 accttttact ttaacatctc cgcaatctgg atcttttgtc aaaatcaaat aatgagtctt 1887481 ataaggcatc gtctcaactc gatcagttgc actaaaatca aaatgatccc ccgagaagtt 1887541 tttttcacta acggttattt catatcctga caaagtcatt cgcatgattc ttgcgttaat 1887601 tgtacatcct tcagtatcga aaatggtgaa tctgtaccca aagtgagatg tccaatggtt 1887661 tgaatttagg tcatcagact tcataaacca tttttcattc tctgtcattg taaaactcac 1887721 tttctcctca tctttcacga taacggccga agcttcccct acatggatag tcaaagccaa 1887781 aagaaatgta aaagctaaca tcaacatctt tttcaaaaga gttcctcccg atatctttta 1887841 cttcaatata ttggaagggt cttttctgat caagacagtc ttctccaaat gaatctttag 1887901 caccatgaaa tgagccttaa taagaacagt tttaacccaa atcaacctct attcgaaata 1887961 aggcttacca atctatattc tttttaaaag tttctgcatt tctttattta gctcctagac 1888021 acatataaaa aatgctccta taagttcagg agcactacaa aaaactgcta aagtgttttc 1888081 tatcgattta ttgtattcat tagctcaaag aaatattcag gcttttgagt cttatttagc 1888141 ttataccatg aacgcaatgt atctggtgca aatacatcta attttttcaa tacttctacc 1888201 gcaaattcca gaggagcaat tcctgatgca gtaaccaaat tttcatcaga tactgcaggc 1888261 cccttttcat agaatgtttc tcctttgtaa ttagggcaga ccatattcat atagtcgagg 1888321 tcattgcttg tgtgctttct cgaatttaag tatccttcat tcgcgaggcc caaggttgcc 1888381 ccacaaattg cagcaatagt cgtgccgagc tttaaagcgt cgccaacttt tttcaagatc 1888441 ggctgatgaa tatcttctcc ccaagtgttt cctccgggta aaatgataag atcttgactc 1888501 ccaagagtac attcgtcaag agaaatatct ggttttatgc ttaatcctcc caacgtagtt 1888561 atcatttctt tattaacccc tactgtaact acttttaaag atgctgcatc ttgtttaaag 1888621 tatctccctg agtttagttc cgcaattaaa tatccatatt cccagtctga cattgtgtga 1888681 aatacgtaga gataaacttt tctcgtttgc atccaataac actccaatca caattgataa 1888741 agctttctaa tagatgactt tgctgacagt cattgtcagc ttttttgttg attctattct 1888801 tatgcccttg ttctcccaac ttataaaaat ataagatcaa ttgattctat gtttactagc 1888861 gcaaaggggt ttgttacact aactgtcatg ggaaacattt caaaggtaat acaaaatcat 1888921 ttgaatgagg aggcctgatg aagttgaaaa ctaaagcgtc aataaaattc ggaatatgtg 1888981 ttgggctttt atgtttaagc attactggtt tcacaccttt tttcaactca acacatgccg 1889041 aagcaaaatc catagaagac acaaacatgg caagctgtat aacgaataaa aaatttgttc 1889101 aacttgagaa aaaatttgat gccaggcttg gtgtttatgc aattgatata ggttcaaaca 1889161 agacaatcgc ctatcggccg aatgaacgat ttgcttacgc atcaacctat aaagttctag 1889221 ccgcagctgc tgtcctgaag aaaaactcaa ttgaaaaact taatgaagtc atccactaca 1889281 gcaaggacga tcttgttaca tattctccaa tcacagagaa acacctagat acaggcatga 1889341 gcctaaaaga aatctcggaa gcggctatcc gttacagcga taataccgct gggaacatct 1889401 tgttgcaaca gcttggcggc cctaaaggtt ttgaaaagtc actgaaacag attggggatc 1889461 atgtaacgaa agctaaacga ttcgagacgg atctaaactc tgcgattcct ggtgatattc 1889521 gtgacaccag caccgcaaaa gcactggcaa ccgatcttaa agccttcact ttagataaca 1889581 ctctcacgac tgacaaacgc atgatcttaa ccgattggat gcgaggcaat gctactggtg 1889641 acgaactgat tcgggcaggc gctccaatag gatgggaagt cggcgataaa tccggagccg 1889701 gaagttacgg gacacgaaac gacattgcta tcgtttggcc gccaaacaga gctcctattg 1889761 ttgtggcaat tctgtcaaac cgctttacga aagatgctaa ttatgataat gctcttatcg 1889821 ctgaggctgc aaaagtcgtc cttaacgatc tcaaataata tgtttagcct tttgccacaa 1889881 aggaaaagac attacttttt taacttctac cgttcatttt ttgatgaacg gttctttcat 1889941 aagacctcta gaatcatata tttaaacacc acaaaattaa acattattat aattaacagc 1890001 aagttttcat tttatggaac aagtaaagtt tgaatctgac aagaattaag actaagcacc 1890061 ctaaaatccg ttttcttttc ttccaagaat atactcctta gtgcaagcca ttataaagat 1890121 acaagtgaac atacaatgca gacaactctc ttaagtctct tattctgtga ccaatttgta 1890181 atactcatga atatccggac tcacttccaa tatttcgtct cgttcgaaga cactaacata 1890241 tcaaaccact tgaattaaca taactgaact tgatattggt cactggcagt ttcaatgcaa 1890301 tagaacaaca tttgttgtct cagaggttat ctatatgaga attcaacaat ttttttataa 1890361 taattcatat ttttgtatcg ttgcacttgg tggatttgac tcttttcgtg tatggaacca 1890421 cacttttatt ttttcacctc ttttgagatc atctgtgtta tcaatctcac ttaatcctac 1890481 aattactatg ttatttttaa acttgttcat aagttgtcct tcagaaagat tgtaatcttc 1890541 ttttcctgga gcttttgtat cggtaatgag aattgccctt tcattgtctt taagcacgac 1890601 atagcctact aggctctgca tctttgtttc gtctccgttt tgttcatttt tattgcagcc 1890661 tgcaaggaaa ataatgagca taatgagcac tatcaagctt actccgattt taggcatctt 1890721 tcttcctcct ctttaaactc atctttaaaa taaacaacag gatatcaccc aacccatcta 1890781 cttctttttg caattcataa cagcagcata ctcattctcc aattcctcaa ccttcttttt 1890841 attctttctc aaatatttgc atgtggtagc cctcgatatt atccgcttac tcatttttgc 1890901 gctttcaaat atattattga aggccgcttc tttctggatt ccagcataaa tatacttatc 1890961 cttactgtcg tttactatcg caacttccat taaaatcgag atttttactt tttttatgat 1891021 ccattattca cttccaaaat aacttccaat tacaacataa tatatgtata aattgtaaat 1891081 ggagttgatg taattgaaga ttaggaaaat cttattgagt tctgctttat cctttggcat 1891141 gctaatatcc gcggttcccg cattggctgc tggcacttcg tctgaggttg cagtaaaaaa 1891201 tgaagaatat gattatgaca ctatataccg cattagtcct ctgccaatgg acttccagcc 1891261 aacaatagaa tacaacggtt atacttatac gcttacacgt cattattttg attactcaat 1891321 cgggttttac acggctattt atacaaaagt tgtttaaact tataaaggag ctttttagct 1891381 cctttttctc ttgttttaag caaggtattt ctttctatgt ggtcccctat caaatacaac 1891441 atcaacattc tccagttctc tttgacacga acaaaatcta aagtttggtt ttaaatgctg 1891501 gtaataaaaa attcacttta aagaagtgcc gcccgcaaaa tacggctttt gtacactacg 1891561 ccaattttat attgaaaagc cagacctcct caaagaggtt ccagcttttc ttaatgtgct 1891621 atcgatcttc gttagttcaa cgggaacttt atcattcggt acaaatgcag cctcccaact 1891681 tctagttagg gctgatggcg gaatatctga cggttctcta cacacatcag acattagaag 1891741 atttcaatgt agccttctgt accatgaacg cgaattcgtt gcccatcttt tatcagcttg 1891801 gcagcatttt caacgccaac aactgcaggt aagccatatt cacgggctat aacagctcca 1891861 tgggtcatca gccccccaac ttcggtgact aggcctttta tggatacaaa caatggtgtc 1891921 cagcttggat cggtaaagga ggtaactaat atatctccat cttctaaatc cgcatcttcc 1891981 atgtttaaaa tgacacgcgc tcgcccctct ataactccgg aggaaacagg tagacctaca 1892041 atcgctccgg ctgggagatt ttctcgttta tactcacctg taacgatttc accatcagac 1892101 gtgataacac gtggtggaga tagtttttca tataatgtgt actcgtcttt tcgtgtactg 1892161 atgatttgat aatccagttt atgtgtgcgc acgacttcgt gaagttcttc aaaagtgaga 1892221 tagtatatat cttctttttc atgaataacg cccgcttcta tgagttgttc ggcttctttc 1892281 agtaaagcct gcttataaac gaagtatcga ttaaccatgc cgtattttgg atattcccta 1892341 aacccgctga aattccggat gatatctatc gctcgttttg tttctttggc tttttgttca 1892401 ccatccggta attgcttcaa tcgatctaat aactcttgtt ctttcttcaa agcttcctgt 1892461 cgcccttgct caaatttccg atggccgaca ttaggctcaa aatttttaat attattaaga 1892521 atcattggga caagtgtagt tggtttttcg ctccatcgag ttcttgtgat atcaatctct 1892581 ccggtacatc gcattccgta tttgctgaga taatcataga tcgcgtctcg ggttttgctt 1892641 ccgccatcaa acttagccag ttcatccaaa aagttatcat cttttacatg ttgtaagtaa 1892701 tcaattacct ctggataagg acgaatcaca tctgcgacgt ctaatagcgc aagacccatt 1892761 tctgaagtaa tattatgggg tacagattga gaaagcgtat ctgctgcgtt tttttcacct 1892821 aaccactcgt tcattttttc gttaatccat aatgaagcat tcatagcagt tcgaattaga 1892881 accgaacttt ttgggttaaa taaaatcttc tttaattcct gaatatcttc cagaataaaa 1892941 cgaaataaat ctgatcctga tttcgtttgg atgttttgtt ttaactcttc tatcgatgtt 1893001 tgactgctct caatcaaatc agacacgatt gtcggatcgt tttcaacttg agccggcata 1893061 tctgcattgc ctctgctggg atttggtgct gttttatcat ttggtatcga ctttatgaaa 1893121 tctcgtcgct ttattatggt cataagtgcg tcttttaaga gctgatcgtg ctgccccatg 1893181 ccttttaaga aaacttctct gctgtcaggg gatgccagat gatgtgtgac atcaacaaat 1893241 agccttccac cggctttacg catgggtgca acagtcgtca acagaaaaaa agacaatccc 1893301 agtggtttta tgggatccgt catcatttgt tgatgaccaa cagaaatata gacgtgattt 1893361 tcttggtcac tcgcttcagg gatggggaat aaagtagtga ttggacgact ctgtacaata 1893421 taaaaagtat cgcgggccaa acaccattcg atatcttgcg gctggccgaa atgagcttcg 1893481 atctgtcttc caatgcgtgc cagctgtaaa atttgttcat cagtcagtgt ttgagccttt 1893541 tgctgatcag aatcgatctg ctgtgtttct gttccgcctt cttttcgtcc gtagatagcc 1893601 atttttttag ttgctattct cttatcgatg atttgcccat cctgtacttt aaaacaatcg 1893661 gcagatacca agccagaaac cagtgcttca ccaagtccaa aaccggcatc gatggataac 1893721 acctttcggt tggaggtaat cggatcagcg gtaaataaaa tccccgaagc ctgagggaaa 1893781 accatccttt gaacgataac ggataaatag acttggctgt ggtcaaatcc attttgcata 1893841 cggtaaataa ccgcgcgatc cgtaaatagg gacgcccagc atttactgat atgctgcaag 1893901 attgcatcga cgccggtaat atttaaatag gtgtcttgtt gaccggcaaa agaagcatgt 1893961 ggtaaatcct cagcagtcgc actagaacgc acggcatagg catgttcctc gccaaactgg 1894021 gagagatatt gagccactgc tttcacaaca tcggaaggaa tgtctacttc cataatgatt 1894081 tgccgaatct tccggctgat gttaccaatc tgatctcggt cctcaacttt tagcatggtc 1894141 aattgatcca acaacacttg taacgtttcg ttttgttcga tggctttttg atatcctact 1894201 gttgtgacac aaaatccttc tggtacttgt ataccttgaa tttttgataa ttcccctaaa 1894261 tgtaaccctt ttcctccaac gagcgaaagc tgtgtttttt caatttcatg taaaccgaga 1894321 accaaagaac tcattctaca tctccccttc aaaaaaaaat attgacaaga gcttcctagc 1894381 aggatataat aaaattataa gatggatatc tataactttt taactagaaa gcgcacgtag 1894441 tgtgattata tcaccgtgtc tgtttttgtg caatataaaa agaacctggg aaatttcacc 1894501 aggttctttt cttaatttcc atagctagtc gcattaaaaa acttggtttg agctgattca 1894561 atcctctaag gaaatcctaa agttgggttc tttttgaact tacttgcttt gttcgtagag 1894621 tccccattca taaattggac tttttgttct taacagtccc acctttaact agtataaagt 1894681 tatgaggatc tggttaacta ctagatattt ttattttgaa taaggcttat gtttgataaa 1894741 gaagggttat gtaaaggtgt ctgttgtgag caagcgctga ctacaaaaaa ttgatagcat 1894801 tctcatttaa ataccattct attaacctat agggaaagtt ttaaaaccag atggagaata 1894861 ccctacctcc agcaattcca aggccgttca cctagtagaa aacaaccttt aaccattact 1894921 aacgatttta ataatcattg attataaaac ttctcaagga acgatcagca gcccgttagc 1894981 tacccctgat taaggatgat ctgttaccac actgttacgt tagaacttcc actactttga 1895041 tatccttctg tcgccatgac ttggtaagcc caattactgc ccagattcat tccatggctc 1895101 ttccatgcgt tcacatgatt gctgaaagtg attgtagcgt tgcttccggt tggtctcttc 1895161 gactggcgaa cactccagta ctgcgtaaaa gtagtgcgat cgccatcaat ggaaggtgcg 1895221 ttataacgtg tagttgtata tatgtcatat gtacccccat cactttttac agtaccttta 1895281 tacgttccag taggtctata agtaccccat gaatccacta cataatattc tatgagaggt 1895341 gatctcgtcc aaccatataa agttaaatat ccattgccat tcggcgccca aactccggca 1895401 ttatagttta tcgtcctaaa tggcgaacct gtagtccaac ctttaccaac aacaaaattt 1895461 ccggtattag accaattaac actgtaattc ccgccagacc cattgacagc gtttactata 1895521 ccgcccccat cagtccaatt ttgccagtag tctgtgctag ctgcagaggc ggttgccgaa 1895581 aacaagctaa tactcattaa agctgccgat aatccaacta agaaattctt tttaaactta 1895641 aacatatgtt acctcctata atattttttc cgactttgag gtagcactcg tatacattta 1895701 aaacattctt aattactaac gccaaagctt ttgatcgtcc ccttcagtat aataccacga 1895761 attcatgagc aaatattaaa agtatttgta attcaattac aaatacctag aaacacatta 1895821 taagtggtct tcttccacca tatcctgatc cttttttcgc aggatcacaa ttcttgtttc 1895881 taattcagat ggagtaatat ctgcaatgaa ttcccattga accatttcaa ataaaggaga 1895941 tatacattag agattgtgaa attattgtag ctgccgcttg tctaatgaag ggaagcaaat 1896001 ttatgaagaa tatgaagaac tgaagaagaa aacaattaag gttatactaa gaaagaactg 1896061 ctcaattaaa attattgacc aaatttgagg atgatagctt agatcagttt tacaaagaag 1896121 ttgcaagatt tttatttgaa agggctctga aaaagaaaaa aaagaattga caatcagggt 1896181 aactgtggga tgtaaccgag cctccaattc aaaataaata tctttaactt tcttttttta 1896241 tttaaagagg gactgtatat ccctctttaa aattaagctt tagattgctg ctgaaagtaa 1896301 taaaaattgt acttttgatc aaacccttct tcgctaccac aaagaaaaat aatgaattca 1896361 ataaatgcga taatagaggg gataccagtc cagcaaaaca aaatatatag aataccttgt 1896421 cctactcttc ccaaataaaa cttatgtatt cccagacccc cgaagaaaaa tgctaataat 1896481 gccgctacaa ttttgttctt cttgcttacc atgacttcct cctagttcat tgctaccatt 1896541 tttaaagtaa tgctttcaca ttataatgca ttttccgcca gaaatcgtga aaattttgaa 1896601 attcttttga gattttttat tttattgaga aatgaaagct catataattg aactagatgg 1896661 ttttgggagg catttattca aaatgtattg ccaaagatta cggcaattac gaaaggcaca 1896721 caaattaaca atggaacagt tagctgagaa aattggaatt gcaaaatcaa gttacggcgg 1896781 gtatgaagct gaaagcaaaa aaccaccatt ggacaagttg gttattttag ctagactata 1896841 tgatgtttca gttgattaca tacttggatt aacagatgat cctgatccta aagtggaaag 1896901 aaaaaatcta aaagagtttt tagaaaaacc agatattcac tgggatggat ataaacttac 1896961 ccctgagata ttagatccta tacggaaaat tttgaagttg gttactgcaa acaacaatta 1897021 aaaaagccct cataagggct tttgcataaa acaattattt cattgaattt tctggactca 1897081 tttcaagaag tttattcatg atgatagcta aactttcacc agctttttgt agcttctcac 1897141 ctgcttttat cagagtaatt aaagcactta aaaagtccac taagctattt tgatttattg 1897201 caactgtttc tttataagct ttgtaagctt cttcaaactg atcaaattgc acacctttca 1897261 tagcaacaac agctaattta tctgaaatat ttccatatga ctctgttaaa ctaaaaaatc 1897321 ttttgacatt gattagtaag gcaatgcact ttaaataatc gtgccccaga ccaatatgta 1897381 aattgcctgc agcaaacagc aaatcgttca aaactgtgta cggttcacca ttccttgcaa 1897441 ctgtctcaat ccctttgtat aagtataata aaaagacaaa tgaattttta tctgtggaac 1897501 gctcaggtaa taaggacact ataataactt actttaagcc aaaacatcca aataaaaagg 1897561 ctggttataa ttattataaa aatcaatagg aactataaat atataaagag ggattgctat 1897621 gccaaaatta tatacatgtt taatttgcgg atataaagga ttaattcaaa acccattaaa 1897681 caatgatggt gagtatcaaa aaacatttga tatctgccct tgctgtgatt ttgaatacgg 1897741 ctacagtgaa gatcatgacg taagcttagg ttttattgta actccagatt atttaattga 1897801 cgctgcaatt cagttatacc gaaaacagtg gattgagaat ggaatgaaaa ctgcaaatcc 1897861 tgaagatatt ccagaagaat taagaaacgg tgactgctta aaattcgagg tgttgttaaa 1897921 gcaattgaat agcctaaatc tcgatactga aaactttgaa atcaagggat ttaatggtta 1897981 ttaagcagat ccaagccccc atatgggggc gttcttatta ttgtacagtc tatcagaact 1898041 atttatagaa aaactattta atgtattgta taaatatcac tgaccttttc tttctccatt 1898101 caacttcctt aaccctcaac tgtttgctgc tgcatcacat tcctcctttt tgatttttgt 1898161 gtatcaagcc tgtacaatat tcaaaaaccc taaaggatga tgaacatgtg tggcaagttc 1898221 actttatttt ctgagtttga tgacatcatt gagcaattca acatagatca attcttacct 1898281 gaaggtgaat atcaccctag ctataatgtc gctccttcac aaaacatcct gacaattatc 1898341 aacgatggat ctaataaccg tctgggtaaa cttagatggg gtcttatccc tccttgtgct 1898401 aaagacgaaa agatcggtta taaaatgatt aatgctcgtg ctgaaacatt ggccgagaaa 1898461 cccagctttc gaaagccgct cggaagcaaa cgttgtatca taccggctga cagtttttat 1898521 gaatggaaac gccttgatcc aaagactaag attcctatgc ggattaaact taaatcgtcg 1898581 aatctctttg cttttgccgg cttatatgaa aagtggaaca cgctagaagg caatctgttg 1898641 tacacttgca caatcatcac aataaagcct agtgagctta tggaagacat tcatgatcgg 1898701 atgccagtta tcctaactga tgagaacaaa aaggaatggc taaatcctaa aaatactgat 1898761 cctgattatc tacaaagctt gttgctgcct tatgatgctg atgacatgga agcatatcag 1898821 gtatcttcat tagtgaattc acctgagctc attgaatccc attaagtacc actgccatat 1898881 cgctttatat accacctcct cttagctaat atgttctaag taggaggtgg tattttgttt 1898941 gtatctccaa tgctattgca ttcaataaaa gagccttttg atgacgagag ctatatcact 1899001 gagcttaaat tatcaagact aaaattaaaa taagggctca tacatagttg atatatataa 1899061 tatgtattga gacctttatt gaacaaacgc cccgtttgtt aaagtggaaa tctctataat 1899121 taatagccga cttttaaaag ttccaatcta aaattatcct ctaaatcggc tagcttcatt 1899181 aacttctccg atataccttt ccaatcttta tttacagaca tagaatgaca tatcccaaac 1899241 accttagcct gttcagtctt caacactgat aaatgtgaat gcctatcttt aaaatacatt 1899301 gcataatcgt tggcccttct tgcacttaat tggaaaagga agaatgttgt atgccttata 1899361 gtatcagctg taataggggc atttaataat tgatcagcat aaaaacaaat tgcttccctt 1899421 ccaattaacc ctatatccac tttttcgaat ttccgataag ttctcttaaa ataatcaatt 1899481 gctctctcgt atatttcgtt attgtctaat gtgacaacct tttttgctgt agaccaatat 1899541 ttattgattc ctttcctata cggaatcctt tccgccatcc aagccttctt aaattggtcc 1899601 agtgataatg gaacaaatgg aaagcctgct ggatcttgca cataaatatt ttcattatcc 1899661 atttggtacc ctagaacata atggtcagaa ccatttaaat ttttatgatt cggatggtat 1899721 gttagctccc ccatatctaa agggcctaga atgacagggt tttgtttgat ttgctgtttt 1899781 aataacggaa atgggtcatc taagtcacta gcttgctgat gttcttctgc agtaaatcca 1899841 aggatgttta aagcataatt gataccatca tcaggatctc tcatactaaa ataaaggttt 1899901 ttttcatatt ctatcatggc acctaaccca acaccagtta atatctctac aagttgagga 1899961 gatacatttt ctcctattga tgaaagaaac attgcagttg aatttgaata acagtaatgg 1900021 ccatttccta tatacactaa catcacctcc gggtagataa gttaacctta caattttgaa 1900081 aattgaaaat ccatattaaa ttgctccgtt ctcgtattca tcatctggat catttttatc 1900141 aacaataatg atcttctcgc caatctccgt tttacgatcg acctctacgt attcgcgctt 1900201 gatgctgcta agtgtttcgt cagccagtac gtgaatcatt acagttgagt tcgctttaat 1900261 ttccgtcatt tactgcaccc tttatatttt ttttatgttt tttcaattct ttttagattt 1900321 tcatattgga tttcactctt ttaattatag aggcgtgtca tacacatgcc atctaagaga 1900381 gataggacaa ttttgtcttg gaggtgaaag ctaatgaatt ttcttcttga tctttttaca 1900441 aattggactt ttgataaagt cctggattat acactagctg ctgtaatttg gtctgtattt 1900501 aaatccagat caaagcagaa taagtatcca ggctatttcg agaaaatacg ccgctataga 1900561 aatttacatc cccttctgcg atcgttatcg atgcgtgtac ttttatcgat aacgatccat 1900621 ccttatatgt ttagttaaaa actatctttt atttagactt aatgggataa aatcttcatt 1900681 gtaaaactct tcccactcag caattaagtt tctataatag ttttggttag agtcggttgg 1900741 catagattca atattgtcaa aaccattaat accgacatct aattctactg tcactaatcc 1900801 ttggtaaaac ttcttataat tctttttaat tactttgaaa aattcaacat caaagaagtc 1900861 ttcatattca gttgctccac tccaagaatc ataagaggac ttaacacgat aattaaaaag 1900921 aaccaaaact aactcatctt tcacatcttt tgatatttgc tccattaatt gatttagtcc 1900981 ttcactggca ttaaaatcta caatgcttaa tcggaagtca atccaagtaa cagcttcatc 1901041 ttttaacctt ccttctccgt cttcattcac ttcaattaat acatatctgt cagccataat 1901101 tccctcctaa tttatttgtt taaaatcacg attttaacta tttatgatcc attagtcact 1901161 tccaaagcaa cttccattta actcataatt aatatataaa atgtaaatgg agttgatata 1901221 tttgaacctt cgaaaaattt tattgagttc tgctttatca ttaggtatgc tggtatctgc 1901281 tgctcctgtc ttggcaacaa gttcttcgtc tgaagtgata gtaaaaagtg atgaatatga 1901341 ttatgacacc atatatcagc ttagccccct accaaacttc aagccttcta ttgaatacaa 1901401 tggatatact tatactctca cacgttatta tttcgattac tcaattcagt tttatacggc 1901461 tatttataca aaagttgttt aaacttatag ggagcttttt tagctccttt ttcacctttt 1901521 taagcaagat atttctttct atgcggtctt ttatgtatga aatcaaatgc tttccctaat 1901581 tccttctctt ctgttaccgc tgagtccata tcttatattg catctaaggt ttagtcagtc 1901641 gagatcattg aatatatagt actttactca gaacattttg cttattaagg acataataag 1901701 tgttcgtatt aatttttcct gttacgataa cgatcaaaaa caaaataatt tatctcattt 1901761 taagacagaa gttattctgc tttttcaaaa aaatattctt gattttccct tttttagatg 1901821 catccataaa gcattcgatc ataaccatta tatgtaactg aaatgcaggt ataagagtta 1901881 ttatataggg attacactac cattatctgg gggtgtatta acatccaaat actcaaaagc 1901941 aagaacaaat gtacccatag cacttccatt tccacaccct atccaaattt tcattttcct 1902001 aattccacat caaaatcacc ctttttcaca tcgtaatcac tatcgtaaaa gcctatagta 1902061 tcaacgtttt tccttcttaa aattttcttt ttttataaat atcttcccaa aacaaccact 1902121 ttcccctact cccgcttatg ttttacgatc gtttaccccc tatttactaa ttaaagtatc 1902181 aaaaattctt atgtttactg tctttttagc tcattataaa tttttacgat aagcaattgc 1902241 ctttgctttt ggatatgact tgactgtatt tggtgacgat ttaacagaga aatttaatgc 1902301 tcttctgact tttttaactg cattgggcat tattgttgat ccaacaactc aaggtatttc 1902361 tgatagtgaa caagcaatgg attatgattc accgagataa accccatacc cttctcttga 1902421 ttgaggaggg tatttttttc gttttttcaa atgaaaaaat tgcagaaaac tttacatcct 1902481 tttacaattt tttcaatgac tatgttatga ttgttttcga gagatttttg aaattttcag 1902541 aaagaggggt ttaaatgagt aagatcgctt ctgaagttgt cgctactaca ctgaatgact 1902601 ggtacattgc tataaaaaaa caaaaggttg atgaatcaat aaaatattat tcagagataa 1902661 agaaactttt tgatgaaatg gaagaagatc aagaagttct tgcgtattat agtctattag 1902721 aagaaagaca taaaatgttg ctgcattctt cacgaggaga gcctttacaa aagcacacct 1902781 attttactga agacaatcaa aacttcataa caaaaacaaa tgataaatta gaatacaact 1902841 tttatttatt tgaagcaatg tacgaggcat acaacaaaaa ctatgatcga gcaattaacc 1902901 tatatggatt agctgagaaa aagcttgcag aaattccaga tgaaattgaa gcagctgaat 1902961 tttactctaa agtctcttac ttatatactc ttgttaaaca aagcattgtg gcacaacatt 1903021 atataaaaaa tgcaatttca atatataagc gacaccctga ttataaatgc aaactagcta 1903081 catcaacaat gattgcagct gcaaactatg ctgatatgaa acgatttgag gaagcagaac 1903141 aatattactt agaagcaatt gatattgcaa aagaaacaaa agatgaattt ttaaaagctc 1903201 aattatttca caatcttagt atcgtttatt ctgattggaa caaacctgat aaatgcattg 1903261 aatctcttga aaaagcaata ggaaatgaat cttggttaca ttcgatttat tatataaatt 1903321 ctttattcat gatgattaaa gaactcttta aaattgacga aaaaatgaaa gccattaatt 1903381 tttacaataa agcacaggaa agactcatat taatggagaa taaagtatac gaagccaaaa 1903441 tcagcatcct gtataacctt tattgtgggg aattaaaaaa taatttcaat aattgtatta 1903501 gtaatattga gtttttaaaa cagcaaaatg aacttgaaag tgtagatgaa ttgtcctaca 1903561 tagctgcaaa aaggtttgaa tcaataggtg cttttgaaga agcaacgagc tttttcaatg 1903621 cgaaaatttg ggctgaacag aaaatgaatc aggtggaggg aatcttatga aaaaacttgt 1903681 gctttgcgta tctattttag ctgtgatttt aagtggagta gctttaacgc aattgagtac 1903741 agattcacca tctaacatcc aggtagctga aaggccagtc ggaggttaaa aaaggttgat 1903801 taattaattt agccctactc aaacatttga gtgggctttt attttatgat ttatgtccac 1903861 cggtcagccc tgctctgtgg agcgcagtac ctgcaaacgt aactgagata cttctcactg 1903921 ttttttgccc gagtaaaact tattaaagaa catcaagcaa cacttataaa tatccatcgt 1903981 gatatttgtg ggaaaatcaa ttgttttgga tcgatgaaaa ccaccgccaa gctcatcttt 1904041 actgtatcca attcctagac ttattgttcg accaacttta ttatatgtac gtgcccttct 1904101 tgcgacttcc tcacaaatct ccaagagcac agctttaatc tcttctctct ttgtataatc 1904161 cctaaacaaa atctgactct taccaaaact aatctgcccc tgcatcaatg gagctcctat 1904221 ttcagataaa tcaattccgt gagcatgata gtacaactgg tttcccatta ttccgaactt 1904281 cttttcaagc agctctaaag gaaatttagc taactgacct acagttgata tacccattcg 1904341 attcagattt ctttccatcc tccctcctat cccccacatt ttagacaaag gtcgaacttt 1904401 ccagagtcta tttggcacat cttcatatct ccaacgtgca ataccactct ttgttttctt 1904461 actctccagg tcaagtgcaa gcttactaag caacatattg tcaccaattc caactgtgca 1904521 catcaaacca aattctctcc acatgctgct ttggattgct ttggccattt cttcaggatt 1904581 ctcttttcct gcatctaaaa aagattaatc aattgaatac gtgtggacac atttttcagg 1904641 aacaaatctg taaaacagct ttgtaatctc agttgaaact ctgatgaaaa gcttcatttg 1904701 tggatttaca atgtatattc ttggatcttc aggtatctca aatagtctcg atcctgtttt 1904761 gattccaaaa tcttttttaa gtgcaggaga tgcagctaac actacacttc cctgtctatc 1904821 cgtattccct acaacggcaa gataacatgt taaaggatta agccccattg ctacagccga 1904881 tacagaagca taaaaggatt tcatatcgac acagagtata ttctcacgtg gaaattgtga 1904941 gtaatcagtc attgtatata actcttatga tgttattcat gttgatataa actgtattgt 1905001 cgttctggtc ttttacgtga agcttttgtt gttcaaaatt aatgtaatgt actctgccgg 1905061 taacattttc aacaaatccc ttgttaaaga gtttgaattt caactcttta ttaaattcca 1905121 atgcctcaga aacgagaata tccatctcat caatttgttt gtcatctaaa gatggctttt 1905181 caacttttga tccatcaatc aaatcttgtt taagctgtat taattgttct agcatcattg 1905241 atgtccattg atagttcctc gatccctaaa catatcgact cactccttga ttgatctaat 1905301 atcaacagaa caaacgttcc ttattcaata tagatcagaa caaaagttcg atgtaaatgt 1905361 tggtaataaa atataaaggt caataatgat atccgtagta ttaataaagg agagattctt 1905421 ttcgacgagg gagagtgtga tggtgaatga agaagaggtt aattggattt ttggtcttag 1905481 ttcctgcttt gattatgtgg ggtataactt taatcgaatc aaacaaaaag acccctgtag 1905541 aagttttaga aagtgcttgg gatgaatttg ggttatttag ttttgaaatt ggaataacag 1905601 atccggcaat tacaataggc atggatcaaa ccaaaagtga agcaaaactc cgtgaatatt 1905661 taaaagataa tctgtctaga gaagccaagg aaaaatataa gatttatata ttcaaggatg 1905721 atactgataa gctggagaaa gagcatcaag aatatttgaa agaaaataat ctcaataagt 1905781 aaaacgccca gcaattaaaa ctggacgtta aaaaacatta gttattcttt attttttttt 1905841 agtattcaca cgtaatctct ctctatcttc tttaaaagag gatatgtagt ttttagactc 1905901 taatgcagtc accaacgctt tattagttct attatttgag atctttattc gtctgccttt 1905961 ttcagcaatt tcagagtaag gttcccctat tttagttaaa aattcagtaa ttgattcatt 1906021 atcaatatgc tttatttgtc cagctagcaa cgataaccta gtatccaatg ttgtaggtga 1906081 ttcaagcaaa aaggttagta gttcattggt gattttcagg ttatgctcat taataaaata 1906141 aattgtatct ttaagaatat cattatttcc atctgtcaaa cagttagaat ttaaatgttg 1906201 tacaaatatt tctttgttaa attgagagag ctcgttgcta tctatgagtt gctttatatc 1906261 attggcatca agggaaaaat caccttgttt atcaataaac tcgtcagggt ttctcaaagc 1906321 gagttggata tgaagtgtat caaaatttaa ttttaactct ttaaaatttt ccggtgttag 1906381 agataacaaa tcattatcaa tcaataattt tgctcttttt tcactaacat ttccgagcgg 1906441 aaagtaaatc caactttgaa tactagcaat taacacttcg aatgtttcgt ctgtaatatc 1906501 ccgactatta atgatttctt ctgagatatc ttctaaaatc gcttcgtcaa atttatcatc 1906561 aaacgcctct atattatttt tagagagctc ttttctatta acaggattgt ttaagaaagc 1906621 tattaagaaa tcaggcattt ttttattgta ttctacataa gaagtaataa cgtttgacca 1906681 gcatgcaacc attttatttt cacggatcac aattggccat aactctttaa tcaattcacc 1906741 aatatccgag atggcaaaag tttttttcat gatcattgca tgctttactc tcttatctaa 1906801 atcctcccga tttaataact ccagaaaact ttcctctggt tcctcaatct cctcagtaag 1906861 taaaactttt tcaacaaata tatcaatatt gtcatttacg taattgataa cagcctgctg 1906921 atcagagttt ttaactgcag catacgttat attgggagca tcatttaaaa taactgataa 1906981 agttttgata ttaatttcgt atagatttcg ttgaacaaca aagtcatata ttgtttcaga 1907041 atttagcaaa tgatccaaac ttttaaattt aacttggagt tttaatagta gttcttttat 1907101 tttctcctca tcagatacta agctgagaag atttaagtac ttggataatg tgaaagacat 1907161 gaccgactct ttattcattc ggataatatc agctatatca gcatatgtaa gtatatctga 1907221 caagtattcc tcttttttct gttgtgtata attggatcta agttcaataa aactccaaaa 1907281 atcatcccat ttactagata tcgattggat aaaggcagct ttatttattg ccctttcttt 1907341 aaaaccatct atgaatgtaa cagattcttt acttccattt gcaagtcgct caattatgct 1907401 atcataataa ttacggtatt cagaatgatc cattatatag tttaagagat gaaaattaag 1907461 tacctctatt tgcttaaatt cagcaccaac taatttgctc attattttac cgatattatc 1907521 cagctcaaag ctgtaaggca atgactcgtg gtttttaata ctaaatacaa atttaatatc 1907581 ggaaagactt aaactttctg gatagaagta agtgatgtaa tggttataca tttcatcaat 1907641 atatccatga cgtagcaggt aaacaagtaa ttttttctcg taaagcttat cagaaaatac 1907701 atcctttgaa ttcatttttg taattaatac ttgtaaagat tgcgctctta tttcttgctt 1907761 ttctctctct aattccaata gttctttctt gaatttttgg atttcatttt tctctatagc 1907821 cttgatggca tcttctcttt caaagtagtt cggtttccga ccaaaaacag ttgcaatttc 1907881 tttaattgtc gctggaccat ttctatttct taaataacaa tagatagtat ccgcattttt 1907941 taacttctca aaaaaccgat ctttattaga tgtattgcct ctaaatacct cgccatctat 1908001 attaatatca taattagaat tcaaatttga tatttctaat tcgctcaagt atataaaatt 1908061 taattcagca attgatttta aagactcaac ttctatattc gctaatttcc tctctaattg 1908121 ttgtatttta gcattaatta attttatttg ttcctcaatt ataagttgtt ttttttgaaa 1908181 gatttcatat accaaccctt tgttatattg taatttagaa aaatccacag gataaatatt 1908241 tttgtagatt atcattgcta acattttgtt aggatcaaga tcaattgcac ttagtttttg 1908301 ttggtatata acaaattcat taaaaatatt ctttaatact ctcatgtcat caatgtaaat 1908361 tgttacatcc tctaagaaat gagtgtttat caaatcagaa tatggtgaat gttttatttt 1908421 ctttttaagt atgtctcctg aattagatgc attaataatt ggtattactg ggataataaa 1908481 atcaaaaaat tttgtgcggt ctctagttaa cttttcagtg tctgcatctc caaaaatatc 1908541 atcttttatc gcatatataa aaacaacacg tctatctatt tgttctgaat tatttataag 1908601 ttcatttaat tctcttaatc tttcaaaaat acctatatta ttaaagcgat ctaagtcctc 1908661 aaatattaca acattatact tggaggcttc aaaaaaatat aatatttcat ctaaatattt 1908721 atcaaatata gaagagtttt cttcccctgt atttttttct aacgttgtat tagcaattgt 1908781 aaccttattc aattttaagt tggcacggac aaaatgataa attcttttat atgcgagtag 1908841 aggatatact ataaagaaca gtgctaataa tatagtcagt cgtatttgtt gctgatcttc 1908901 agtaccgaga ctccttgaaa ctaacgtctc agcatatatt cctttaagtg catcaggttt 1908961 aaaaaggtag atgccaacta taataaatgc aaaaaagaaa atcaaattta taattatgct 1909021 cttagtcctt atatgcttaa ttcttttaaa cctagaaaag ggaatggttc tatcgtgtac 1909081 ccggtatatc atttgttgca agatgctttt ctctaactta ttctccatat catccgtatc 1909141 tgtgttgaat gtagctaagg atatatttaa gaaactatat tccctgctgt attgtttttg 1909201 aaaggtattt aatatgctac tttttccaga cccgtaggga ccagttaggg cgatattttt 1909261 cactttttta ttttctaacc cccaacttag tgctttagaa tattttccat cagtgtcgac 1909321 atcattgcta ggagaaagat cttcaaaaag gctttcttcc ttaacattag gttcttttag 1909381 tctaatcaga agtttctcta accactgcac aaattttttt ttgatttccc ccaaaaaaaa 1909441 caaatccttt ctaaactttc aggtgtaata cgaattaata aaactggagc aaagaactaa 1909501 ataaatgagt atgtagcaat gacaaatcat ttctcttcca tctaatatag tcctttatcg 1909561 ccagttgaaa ttcactatta attgtaacat gaaagggcat taaaagtttc tgaaaaaaag 1909621 atgatcaata aacaacacag cgcccaatta caggactgtt tcatatttaa attgaatttt 1909681 tataagcatt aattgcttca tttcgcagca gcatattatc tttgttaacc atgcctaagt 1909741 tgtaagcttt tttgataata tctaatacct gagaatctaa cgccgaaaga ttaccgcctg 1909801 gattaaatct tgatttccaa taatctaaag aattatttag gtcaagtgag ctttttttgt 1909861 tctcgggttt aactacttca tttttctcaa gtgtttcaca gaattcacta aaaccaatgg 1909921 atctactggg agctgagtta tttcccccgt atccttctgt agccaagctg caaaatgcta 1909981 agaattttgg atcataaata agatcgcttc agtttacatt taccactgat aatcacaatc 1910041 ctctcaaagc tttttataat tgtagcacct tttccatttt tacacatatt aaatatcgac 1910101 aatcattcaa atgatttaat aattgaatac aaaaaagaac ctgcattttg caagttcctt 1910161 tcacgttgtc aatatattgt gaatttttaa cgacaagggc atttatgtat agtatgatat 1910221 ttcctgtaca gtaagttttg ctcactcgag ggagtcttgc tcatccccta atgaaagggg 1910281 tgatgctatg tcaacattcc aggcattaat gctaatgctt gcaatcgggt cgtttataat 1910341 cgccctattg acgtatatag aaaaaataga cctcccttga gcctcagaac ctgaagggat 1910401 aggcctacct agaaccacat cgagcaagcc ctttgatggg caactttttg tacagagccg 1910461 gggtgttggt agcacctcgg tcttttttat tttatgcatt tctcattaaa gaaatgcact 1910521 gtaatgtatt gtaaaactga ttataacaca ttttccgtga aatgcattac aataaacctc 1910581 aagagacttg gaaagctttt ttattgtttc ttgtaacgtt ataatgatct aaaatagcgc 1910641 acaagccttt atacatcttc atcatttctt actcttctag ctcgtctttc aacattccaa 1910701 ttcccaatct ttccccagac attcttgtta gtccatttcc ctagcttagt tttatcaaac 1910761 cattcctgaa acaaagatat ttcatctttc ctttgcattg tatcttttaa aaggaaataa 1910821 tgtattatcc aaaagatata aagagctgaa caagaaagtc caaaaataag tttatttacc 1910881 tctaaccaat ttcctaaaac ttgttcgcct aaatatttat catatagaag gggtataaaa 1910941 gcaaatgctg aagcaccgac aaaaaaagct agagtttctt taaaccatct aacaaaaaca 1911001 aaaacagcgc ttaaaatata attcgttcta aaaagaactt tataccaatt ataattcttg 1911061 tttagagtaa caaatatact tctatattct ttattaactg cttgatctaa cattctcatt 1911121 ttataaaata attttttcct attctcgctg ttcttgttta aaatatactc tctgaaacaa 1911181 tcttctgtat tcaaaatttg atctatcaat aagatgtttc taagttttga tagcttcccc 1911241 tttttcccac tatattcttc gaaaaatttt tctataagga ccattttatg gttttcatct 1911301 tcttcattct ttatttcttt tagggaataa tacataggct ctaaaatttt ttctaatgtt 1911361 tcacctgatt gagagtagaa tcgttctata cttttttgtc tttgattgaa tagcaatgca 1911421 actatacccg taattactgc agtaagaata ccattttgtt gtatccaatt ccaaatatct 1911481 aataactcca attaagcttc tccccttctc tctgaattta cttttaatac gggctaaaat 1911541 aaaaaaggtt tcatataaaa cgggactaga aaacttctgt cactttaatt atttaatcca 1911601 ataaaataag ctctcattgc gagagcttat tttatttaga ttgaggatgt gcaactcaag 1911661 ccttctattg cgctatagca atacttttgc ttaatcgtcc cagtcttcat cctcatccca 1911721 gtcatctttc gcttcctgaa tcttattata aaaaaattca ataaagctgt ctgcaacagt 1911781 atcttgataa ccaattaccc tatcccattc aactacaggg cattctccgt ctttcatttt 1911841 atttgtatct agacagtaag caaagtaatc aacatcttca ataaccacaa gtccatcagt 1911901 aaggccatag tgttctttat attcattagt tctatttaca actgatgcat gatcaaagtt 1911961 gtagcctaaa accaaaacgc cgaataaacc accagcaccg tatttttcta aaaaccattt 1912021 ataactgttg gggagatcgc attggaggtt ttcttcaatg cgaccaatgt tttcatgact 1912081 tgcaccttct gtaaatatag cattttgttt attttcatta ataaagttct caaccttcga 1912141 ataaatcata taaacacctc aattctcatt ttcaaattgt ttcgctctcc atttccaata 1912201 tctctttcta aagctctcgt attgtgcttt taaaacctta tcatttctaa aactttcacc 1912261 atcagactta agctgatgaa tgacatcact atattttgta tgtaagctgt tcgggatttc 1912321 aagcattggg ccaggttctt cttgaatcaa gtgatgtaaa ttaatctgtg taccgtcttt 1912381 tgcataaggg gcattcccgt ttttcattag ctgaagattt gtaacaccga attctgtttt 1912441 ttgattaata tcaatatctt tcatagtata cactctacgg cttacatctt taactttccc 1912501 cttcgccttt accttcccct ctatttcata tgcatcatac ttttctttat ttagccaagg 1912561 agggcttttc ttttggccag taaacggttt tcttgttcca tccggtattt tcttcgcatt 1912621 agtcaaaagt tcattcttaa ggttttggct atcaaccaca ttgtatggca cgttatctgc 1912681 tagagcaagc ttatacttag ggttgtaagg cagcaaatct ggaatcttaa cgtccttgat 1912741 tttcttacct gcttgacttg ctttatttat taccttgccc gctgcatctg ctttgttaat 1912801 ggctcctgca ccttttgtac caacaacagc tacagccact gaaccaatag cataggtaac 1912861 ccatcttgat ctagaatagg catctccatt caccatatcc ttttgatatg actcttctat 1912921 tgctgctgaa atggcatcgt atgttttcac tggatgcata gctgcattac ccagtgctga 1912981 gagtgtttct cctggatcgg tgatgaagtc ccatatgccg gttacagtgt cttttcctac 1913041 atcgtataaa ccaactccta caccttttac gatatcccag gtgatttctc ctgctccttc 1913101 tagctgcttc gcttgttcaa tttgcactgc aagctgcact tgagttggct ccagattctc 1913161 gtaccctact ttcttagcaa tctctaaata ttcatcaggg tcagatacac cgtcattaag 1913221 ttttttcttt aattccttga tttcacgttc ctttgcttct tctttcttca cacttaagta 1913281 agcttcagaa tgcttttcaa tatcgccttt tttcttatgt atgtcacttt ctctgtacgc 1913341 tttagcgtta tagtgaattg gtgtagcgtt ttttcctttg cctgttgatt cctgcagctt 1913401 tttaaagtct tgctgaataa attgttcgtt tggttctgtt tcagcgtatt ctgtttttaa 1913461 atcctcatca agcttgttta gcttatcgat tgttttttca cgtttgtcat ctgcagaaga 1913521 aagtttgtct ttgaagtctt ctgttgagaa tatttcaagg ggaaggatat cattgatgtt 1913581 gtttaatatg tctttcattg cttttttctg ttcagacata atggattttg attttgcata 1913641 agcgttagcc aactcgtgtt ctagaaagga ttcttctatg taagcatcag acatcttcgc 1913701 atcttcaagt gttgcagaca tgctgcttaa gaaagcaatc ttcatatcga taagatcaat 1913761 ccattggtct gttacgccga catgaccatg ataaaatgct ttaatgttgt cagcaccctt 1913821 gcctgaaaat tcactgtcat ctaggttagc tacttcctta aacgcttttt tgagcttcac 1913881 catttgcgac cttagttcct tatactcttt ggttctttta tccgcttcaa agagtaatga 1913941 atcagcctca aataccttca tatcattctc cttcctagac tacttctatg taaattttac 1914001 cacagtaatc taattgaata acagaaaaag acagccaaaa tgactgtctt atacatcaca 1914061 cactatcttg ttctataata attttctgcg gtatagtagc gccaatccca aaaaggttcc 1914121 ccattggcca atatataccg gtctaaaaat ttttcaaagt ttaaatttaa tggattatat 1914181 tctaaaccac tttcaaatat atagagatag ttgggatcac cttggttcac tttatcttta 1914241 tcgatcatta aatggcattc ttccaataag tagccaattg gaataccatt gatatcttca 1914301 aacaaatctt catattttaa ctcctcttca atctcttcaa ggctaaatag ctgaagtcct 1914361 ccacctatat tctccccatc agaaagaatc tcaaaaattt tcgcaccgtt atgtagtgtc 1914421 atgaacttct gataatcctg tggaagggta agctggtgtt tagcctcaaa gctttgaatg 1914481 tcattcaggg ttgctttgtc ctgtgaaaaa gtaacaagga actccatgat atcaccttct 1914541 gaacaaaaca attgaatggc tcctttttcg tctaaaagac ttttcaagcc atttacagtc 1914601 ttatgaacaa agttagtcac atacatcacc cctttatttc cttttaacaa taacctttca 1914661 aattccaaaa gatgtgaaca gatcgtgata ggtgctcttt tcagtgaata taatgcaata 1914721 aattctaaaa agaggtgcct ccaaaaattg aattctctaa tgaatgatga catggtaaag 1914781 atcattagaa atggccttag cgcatcgcag catccaaagc acattcttgt tataggagct 1914841 ggattgtccg ggcttgtatc agcatctttg ttgaaaaatg ccggtcacag agtaacgatt 1914901 ctcgaagcga gcggcagagc gggcggccgt gtctgcactt tgagatctcc ctttagtgat 1914961 gatttgtatt tcaacgctgg cccgatgcgc ataccgaata accattcgtt aaccttagaa 1915021 tatatcaaaa aattcaaatt gccaacaaat gtatttatca acagaacccc gatggacatc 1915081 atttatgcaa atggaatcaa aacacgtctc caagtttttg aacgagctcc tggaatattg 1915141 agatatccag ttgcaccaaa tgaacaaggg aaaacgtctg aagagctgat gctttcttta 1915201 ctgcagccta ttctaaattt tatcaatcaa aatccagcaa gaaattggcg gattgtcgaa 1915261 gaacaataca aaaatcattc gttaagctct tttttaaaca cgtatttttc atatggcgcg 1915321 atcgatatga tcggtgtact tttggatatg gaagcgtata tggggatgtc ccttgttgaa 1915381 gtattgcggg aatctatctt tttttcatcc cccgctcact tctatgagat aactggcggt 1915441 atggatctgc tgcctcacgc gtttcttcct caattaaaaa caaacattct ataccatcaa 1915501 aaaatgatga aaatgtctca gggtgaaaat cgtgttacga tccattgtca gcatcaacaa 1915561 acggcagaat tcacatcatt cacagctgat ctcgctattg taaccattcc tttttcaaca 1915621 ttgcgatttg taaaagtcga accataccat tcattctctt actataaacg gagggccatc 1915681 cgtgagctaa actatatcag tgcaacaaaa atcggcatag agtttaaaag ccgattttgg 1915741 gaaaaagccg gtcagcacgg cggcaaatct attactgatc ttccgattcg tttttcatat 1915801 tatccaagca gaaatattgg agcaaatgga catgctgtca ttctggccag ctatacatgg 1915861 gccgatgagg cactgatatg ggacagtctt tcagaaggag agcgaatcca gtatacttta 1915921 ctgaatttat ctgaaatcta tggtgatatt gtgtggtctg aatttgtgtc tggcacttct 1915981 tttagctgga gccagtaccc gtattctgcg ggaggtttta cagctttcga accaggacaa 1916041 gaattagagc tgtatcccta tattcctgtc cctgagggca gagttcattt cgccggagaa 1916101 cacgcctcac tcactcatgc gtggatgcaa ggcgcgattg aatctggaat acgtgttgct 1916161 tatgaggtca atcgcttacc ttagatcatg ctcacatctt gttaaaactg gttgatataa 1916221 aaagaagtga agaatttata ctcctttgtt taaaagatta attcaaatat gggatgtctc 1916281 aacattcggt tctttattat ctttatacac gttttgaatg cggacctccc ttttcttcca 1916341 taatcattaa taaataccca accataggaa acgttttaat taaccatcgg gcgaactttc 1916401 tttcactgta taacgattct taatgttgct ttttatcctt tacttgtcct ctcttttttt 1916461 cattgactta catttcttga aaaccagtat aaatcctaaa ggaattttgt aacaaataca 1916521 gaattggaaa gagaagcgcc aaaagaaatg ctaactcctt atctcaaaga caaaactgcg 1916581 cttatattaa aagaaagagg tgtctttaga atggttcatt ttaaaaactg ccctgatcct 1916641 tctctaaacg ccaattctca gtctcacccc gaattttcat ccgaattaga acatattaag 1916701 acaagaatgc aaaactttat taagcactcg gttacagacc aaaatatcga agttactgac 1916761 gcaagggtga cggccgaagg agaggtcacc tctcttttaa aagaacgtct cgacaaggaa 1916821 tattataggc ttttatctaa aatcacccgg gaagtaaatg tggctgactt cggcgctgtt 1916881 ccagatggaa gagacaatac tgaagctttt cgaaaagcaa tcgggaatgg ccgagtcaaa 1916941 gtacatgttc cagcgggaga atacctcgtt caagggatta aacttccatc ttggacaaca 1917001 attgttggac aaggtaaagg gatcacagtg attaaattgc atgaagacac tccagcgcat 1917061 gaatgggtga ttacaaatga tgattatcaa aatggaaatc gcaatatttt tgtccaagga 1917121 atgtcattag actggaatcc aagtagacaa tgcggtgtga gaaatccagg gggacagttc 1917181 tccagttgtt taacttttgc taaggttgaa tatgggtgga tcaaagatgt ggaagcgatt 1917241 aacgcaggtc ttcatggtat tgatattaca tcgccaacgt atgaccattt gcctgatacc 1917301 gattggacaa aagacggatc aagatatatt tggatcgata actgtgtgac atatggttca 1917361 ggagacgacg gcattaccac ccattatagc gaatacatct ttatttcaaa ctgccattca 1917421 ggaaatccgc ggggaacaga atttgctgaa ggtgtttcaa actccaacgg aatagaaatt 1917481 gacgacggct ctaggcatgt gtggcttttg aataacttta caagcggcaa catccgcgga 1917541 gttgaagtaa aagcccatga actgtggcca gcctctcaaa acgtccatat cataggccat 1917601 atttcttatc gcgatgttcg tgcatttgat cttcgtcata ttggtcacca tcaaattaca 1917661 gatcctgaaa gcacaacagc atacgatgtc acactcattg attgttcagc agttgaacca 1917721 gttttcaact cgctttacga tgctgtgacc ccaagagcgc tggttatttc ggcatataaa 1917781 aacgttaatg taagcggatt cacagcgatt ggtgatccag actatgatta taaagaaaac 1917841 cctgtcgtag ccttgcaata tcgcagccaa aatataacca ttaatggtat taaaattcgc 1917901 ggttttaaaa aagccggtgt tgatattaat ttatcaggcg gatcaaataa aactgattat 1917961 attaaaattt caaattttga tatttataaa tctgctccaa aaggaatttc aatcggtgga 1918021 ggcctctaca atgtcaatat tctaaatgga acgatgatta ctgacaatgg gacagttgca 1918081 attcagtccc ccaataatca ggccacaatt ctcggtgtac aatcagaagg ttatagtgtg 1918141 gcagcctcaa tcaaaggcca aacataccaa caagttccaa tcaatttgaa aggaggcata 1918201 cagcttgcaa cgacctctgg ctttgccgtt aaccaaacaa gcgcagttat agcaggtacc 1918261 ggcgacatta cggcccgcgg agaaagaaat gcggtcatta gctcttctgg aggctccagt 1918321 actgaaggct ctcgcgcatt aatcgcttct tcaaataacg cacatattag aggaaaccaa 1918381 gcgtcaagaa caatactgtc ttctgaaaat attatacttg aggaaccata caccgtggca 1918441 ggaggtcatc aatcaataaa gtggcttctt gactctgttc ggggaaacgg gacgtttgcc 1918501 ggtgcaatca gttcttcttt aggtggatat ggagagtatt ttgagagttc aactggacag 1918561 ttaatccata ctggtacaat cgtgacttta agaggtgaaa aaattgtgcc cgcgaatgtt 1918621 ggagattata tgcttggcgt tatttcagaa acttcagctt tcatttcagg agcctccagt 1918681 ttcgtctggc agggccgtta tttgacaaat gagttcggcg gatttattta tgaaacggtg 1918741 actgatgagg aaagcggtga actcatacgt gttcccaaac aaaatccaga ctacgataca 1918801 gcgctggagg caaattatca ttcacgggca gcaagagacg aatggcacgt tgtagggttg 1918861 gttggccaac attatgtgcg tattgacgaa actgtcaatc aaggagatta tcttacggca 1918921 cataatggaa taggaacaaa agccactgaa ggaagctgga aagtaatgaa aataacctct 1918981 gcttacacat cagaaaaagg gtatggtatc gctctaaccg tcatcaaata gtggatacgc 1919041 cgaccagttc aatatatgtt tatccaaata attagatctc ttttctaggt tctttattcc 1919101 ttgtatgtta ttatcaattt tcaatatcta ccaaaatacc cctaatatac tatcgtaatt 1919161 aacttatatt ataatcaaaa aaattttgac agctgttcct tctcgttatt catgaaagtt 1919221 gctattgaaa tgagtaaatg gatatcatat tagacttcta tagcaaatac accatatata 1919281 tcctttaagt atttacaaat tgaaaatgtt tcatgaggct tattaaaagt attgttcttt 1919341 tatcatctgt aagtcgatac aaactgcatt aagatcacac ctaaatctca ctgagttttt 1919401 tcttacaaat aaaatgaaaa ccctttccat tctaaattca tttcaccgtt actaaaagta 1919461 atccttgcat tccttcgccc tccatgctat attcatatag cgatgagctg aattgtgtaa 1919521 gccgatgtac atgcctttac ggcacacacg aatgtggcgt gtggtgcatc gcctcaatac 1919581 gcaaagacgt ttgccttagg caaacgtctt tttttgcgtt atccgatttt tgtgccgttt 1919641 gggacaggct gatccggctg caaaaggacg acgtcgccct ggccgggtat gccgccgagg 1919701 accaagactt ccgatttaaa tccggcgatc cggcggggcg gaaagttcac gactgctatg 1919761 acttgcttgt tgatgagacc ttccggcttg taacgcttcg tgatttgtgc gctcgattgt 1919821 tttatgccga tttcagtccc aaaatctatc acaagcttga ttgccggtac tcttgcttca 1919881 ggaaattctt ccgcttttac aattgttccc gttctgatat ccaatttctc aaagtcatca 1919941 ataactgcca tatcaataac tcctttttct cctattgtaa aggagatata caatattctt 1920001 ttaactaaag agccatcatt ttttatccga atataaggtg tttcgataca ggcggggcgg 1920061 cattcctgtg cttttcgtga accatcttgt aaaagaagaa aggttttgaa agcccagcgc 1920121 ctcgctcacg acggtaagag tttcatttct ctccatcagc attctttttg cttcctcaag 1920181 gcgaaggtcg gcaatatagt tctgcgggga cttccctgtc tgttttttga accagcttga 1920241 atagtaagct gggtgataat gctcgatttc tgccagcttc ttaatcgtca gccgctcaaa 1920301 taaatggctg tgaatgtatg caattgaggc atagctatgg gattgaagct tttcttttat 1920361 gtattgtact agcatatgaa gcgagttggc tgttccggcc tttgcttcct ctgtcagcaa 1920421 gtacctgatc gaagaccaga aaggatcgag ggcagcttca attcctgatc ctgcacgata 1920481 ctcatcaatt ttcattgcat gaagcggaac atccagtaca agacattcat ttcttccgat 1920541 agaacggaag cgatgctcgc actgcggcgg aatatataaa aaatgatccg gatttaattt 1920601 cacctggcgc ccctcagtct caagatcaat actcccttca agcggaaaaa gaaattggct 1920661 gtacgcgtgc ttatgtgaat gatatagccg tgtgtatgtc cgtttttcgc aaattatctc 1920721 ttgaagcgag tccattagca aaccccttcc tttggtcatc ttttaatccg gtaatggtgt 1920781 tccgatatag gcgaaaagcc gatttttcca tataaagaaa ctgccgccag attttctttc 1920841 atcacttgta aaaacatgcg ttccgctccg ttgttttttg cccattcagt caacaccctg 1920901 atcacttggg ttcctgcccc ttttcctctg tgctcctcag ctacaacgat attactaagt 1920961 ccgccataac catcaatgac agaaaccgtg ccaagcgctg tcaggctttc tttgtcatac 1921021 atcttgaaaa aagttttaca cggcggcatg cgttcgaata tgtgtttgta acctttgtga 1921081 cgctcgggtg aaaacccttc taattgaata aattcatcta tccaaacaga tgatggctct 1921141 tgttcccact tgtatgtaaa tcggctgttg tcatttgttc ggctcataat tgaccggcac 1921201 aacgctgtca tctggaagca ctcgtctacc ttttcataac ggctgtctgc caatgcgtca 1921261 tcaagccctt tcggtgatgc gttgctaata tgaaaacaaa caggtaagcc taaactttga 1921321 taaaaaagtt cggcctctag ctgaaaatcc ccttcaggca tatccgcaga cgtccatacg 1921381 ctatttgccc ttttggttac gccaaaattc gctctgagaa gccatttccc tatgcttttt 1921441 tgaaaataag ccggccatga agctgccgct aatcgttcaa tcttgcgaat gtcatccatt 1921501 gcataatgcc tctcccctat gtatactccc ttgatattat acaatattca gaaatataag 1921561 acatccattt atttgtttac ataatatttt tattgtttat taataatcct gacaaaaatg 1921621 tccgaattga aaatgacagg ctttctaaaa tgtcctcctc acgttcaaat gcttcttttg 1921681 cgattaaaac agtaaagcca tgcagcagac ttctgagccc ccttgtcgca tgaatggcag 1921741 tcttttcact tgcatagccg ttttcaatga gcagcttcgt cacaagacag acaatttggt 1921801 cagagacgat ttccgtccgt ttgtcgtgaa ccttaagaag agccgcttca taatatccgg 1921861 gattttcaat tgcaaaatca acatatgcat gagctaaaga aagcatcgcg gaatctccct 1921921 ttcgttcggt tacggagtcc gccatttgat caaaaagctt tgtcagtcct ctgacagcaa 1921981 gttctgctct gatcgcttgc agcccgttga tatggttata caatgacggg gggcgaacat 1922041 tcattttttt agaaagtgca gcaagtgaga caccatttac cccttcctga tcggcaatct 1922101 ctgctgcagc gtctacaatc attttttggg tcaaacctat tctcggtgac atgctcatca 1922161 tcctttcttt gctttttgga tcgcctgtct catccgctct gaaggtgatc gcaggaattt 1922221 tccatgtccg acagcgagac aggaaggcgc cttatcggcg agcaattgtg cacttttgat 1922281 ggcctcctcc ttattccatg tggcgaaagc gggaaaagga aacgcccatt ttatctgacc 1922341 tgatacagcg attcctccgc gcaactgaaa cgcatctcct gctattaaag tgccgtttct 1922401 tgtatcaaga aatgacatgc tgcccggtgt atggcccggt gttggaatgg caagcagaga 1922461 accaattgtt tcaccgcccg tcagcagttg gtgaggcttt gtttgtatgt gtttcggaat 1922521 acctcctttt ataggcgtct gcggctcatc ttgccgcaaa gatgtgtcac cttggagcaa 1922581 gaatgaatcc cgttccgaga tcatgacctt tgcatgcgga aatgtttgtg ccaatgtatc 1922641 cagtgatccg acatggtccc catgtgcatg agtcagtaaa atatgctgaa gcggttttcc 1922701 aagctgattc acagcttgaa taatcccttt atagctgcct ggcagtgcgg catcaataag 1922761 ggtgacttcg ttttcttcct ctactaaata gcaattaacc ggaaacaatg ctggaaaaaa 1922821 agtcagctgc caaaccgttt ggtactgagt aattctcatc tttttattcc tcctaacaaa 1922881 aactaatggt gttagtttta ttattaacta acaccattag tttttcaaga gtttattatt 1922941 tttttatcgc tacataaatg ttaacttgtg ctcgctgtgg cactgcggca ttttgatcat 1923001 acatctcaaa gtcacctgta aacgtgcgca gatgccgctt atcccaagtc caaatttcct 1923061 tccacgtttc aagcacaatc tcttcaatag gaccgattct ggaagtgaaa acggcgtaag 1923121 cggaagccgg caaatcaata ttttcatatg gtcccggaag aatgtcgtcg tattcctgaa 1923181 acgttccgac tgaaaacgta taaaacccat tcgtctcttg ttcataattc gaatataagg 1923241 caataatgct cttgtctttt tcagcctgtg ataaaagagc gctcatatcc tgcttccata 1923301 attgatccca cagtgccgga atcctccttt cttccgtcat ttccagtgcg ttgcttgtcc 1923361 gttgtgatag tccggcaaat cgtttcaggt ctaagtgtgt tatatgtgaa aagcccatac 1923421 gatctcctcc tttttttaag attatagaca aagaaacctg acagcagtgt gtcaggtttc 1923481 atatattttt tgcatgtgat gaatggtttc ttttacttta tcccttatat gaagaggctg 1923541 cagaacctca atatcctttc cgaactggag caaaaaaccg atcagccatt gatcttctgg 1923601 aagtgaaatc accgcctggc agatttcatc ttcctcacaa cagtgaagga catcatatcc 1923661 gaaccattca cctatacgct gacgtgctga cggctgaaca agaataacca attcagttaa 1923721 acggtccttt tggtaccaac tcttatccca tggcaaagtg tccagctgaa tgtcttttct 1923781 gataaatgtc tgatgtaaga tggccagatc tttcatccgg ttcagtttaa aaaagcgaaa 1923841 atcatttctt accaggcagt aggcatataa ataccagtgc cccgccttgc aaaccaatgt 1923901 ataaggttca gtttcccgaa gtagtgtttc cccgcttgcg cttgtatatg taaaagatat 1923961 cgttaacaac cgatcgatgg cagcgctgat tttctcgcgc agcgtctttt gatcctcagt 1924021 atggccccaa gccgtcatgt caataaacca tttttctgtt tggtgcttaa atgcttgagt 1924081 agattgctca ggtataaggt gtttgatttt ttgataggct gtgctgtgag aaacgggttc 1924141 atacatagat gaaacgcttt gcaaagcgga agcaattgca aacaattcct cctccttcag 1924201 ccactctctt tcaagccgat acgtttccat gatgccaatt ccgcccccgg aaccctgtga 1924261 ggtcacaatc ggaataccag ccctattgat cgtctcaata tcacggtaaa ttgttctgac 1924321 agatacttca aacagctcag caagctctgc agcctgcact tgttttttgc tgatcaataa 1924381 cacaaccatc gctaacaaac gttccagttt cattctgcgc accttttctt cttgtatttt 1924441 ccaacaaaac aatcataaca ttttgataaa gcttgggcat atctattatg cggcggaata 1924501 cacctcgcat atgctatgaa aacaggggtt tccccttctt ttttgtgttc agtatttatt 1924561 tcagctacta tttccgaccg gataagcata cacttctcaa cggaggggat ttcacatcat 1924621 gcatcttaca cttcagagcg tttatcctgc cataatcatc atcttttttc tgtataaaaa 1924681 aattaaaagg tccatcggat accagccgct gaagccccgc tggctgttca cccgtatcat 1924741 tcttttctcg ctgtttgctt ttggactttc aatcttcagc gccattcacc cttttttata 1924801 tggatatctc attttgggca ttcttggcgg atggctcctt gtctttttcg ctaagaaaaa 1924861 catctctttt gaaaaacgca gaggaaagat ctattttcgg actcatattt gggtagaggt 1924921 gattctctta actttatttc tatcaagatt tctgtatcga gtgacggagc tttatcttac 1924981 ctcacctgat ctaaaccgcc ttggatcata cagtcagtca atcggaacgg accctctgac 1925041 aattggcgtc tgttttctga tagccgttta ttatatcggt ttttcttctt ttatcatcaa 1925101 gctcagcaga aacgaacttg aacagcacga atacaataaa gaaaaagaca tccttgcccg 1925161 ctaacagcga gttaagcaag gatgtctttt tcaatcatgc tgtgtatgat ggatcatttg 1925221 ctgaagaaca tctaaaacat gttcatcctc cggagagtaa taaatcgatg ttccttctct 1925281 gcgcgatttg acaagccgga gattttttaa aaatctaagc tggtgggaca cagtggattg 1925341 cagtaaattc agcttttctg caattccgtt tactgcatgc tcaccttggg acaataaatg 1925401 gagaattctg attcgggtag gatctgaaag cgctttgaat gtttgcgcga ctagaaacag 1925461 cgtctcctcg tccagatcag cagccgattg ttccgtttct ctaaattcag tcatatgtat 1925521 cacctttctt tattcatagt tttatcttat aacaaatgcg cttgagtgca aaccagcctg 1925581 cttgtattcc atttcaatct catagtttaa atttatgttt caaatcaggt ttttacttgg 1925641 tctgatatac cctcttatgt cataataaaa aaggtcatac tgctccaaac attgagggtg 1925701 aaacacagtg aagaaaaaga gaaaaggctg tttcgctgct gcgggtttta tgatgatttt 1925761 tgtctttgtc atcgcctctt ttttattggt cctgcttttt ttcaaccggg atttaatcaa 1925821 aaaacttccg atcgatacga aaacgattgt tttggaacgt ttaaccgatt acaaaccctt 1925881 ggtggaagaa gagcttgaaa gccaaggact ctctaattat acatcactca tattaggcat 1925941 gatgtatcag gagtcaaaag gaaaaggcaa tgatcccatg cagtcctctg aatctctggg 1926001 gttaaaacgc aatgagataa cagaccctca actcagtgtt aaacaaggca tcaagcaatt 1926061 taccctcatg tacaagaccg gtaaggaaaa aggcgtggat ttggatacca ttattcaaag 1926121 ctacaacatg ggggcaggtt acattgattt tgtagctgaa catggaggaa cgcatactga 1926181 ggaattggca aaacaatact ccgagcagca agtcaaaaaa aatcctgatc tgtatacttg 1926241 cgggggaaat gcgaaaaatt tccgctatcc gtattgctac ggtgattata cgtatgcaga 1926301 aaaagtaaaa gaaaaaacaa aaactgttga agaatctttg caggttgcaa cacttgaaac 1926361 catggaatcc aaggctcatg aataagagtc tatcaattta ctgacaaaag cccaaaaatg 1926421 aatttgggct tttgccatgt ttacacgtaa aaaaagccat actgagtatg gcttttaata 1926481 atacggtgaa atcatcaaat atacaataac gcctgtaagg cttacataca gccatagagg 1926541 cattgtccat ctcgcaattt ttttatggcg ctccacctgc atgctgaagc ctctgatcag 1926601 cgtaaacagc gcaagcggca caataattgc agaaaggcag atatgtgtaa ttaaaataaa 1926661 gaaataaatc gggcgcataa taccttctcc gccatagagc gtgttttccg caatcgagtg 1926721 gtacgtcaca tagcaaatca aaaatagtaa tgttgttgtg aacgcagcca aaataaagcg 1926781 tttgtgagct ttgatatttt tctgtttaat cataatcagc gcggccaata agaagataaa 1926841 cgtaaagcta ttgaatatcg cattcagcat tggcaaaatg tgaatattcg catggctgaa 1926901 ctgatctaat ttaggcataa aaaacagcac tgcgattaaa ccgttaatca gaactgtcag 1926961 cgtaaggaca atccccgtgt aatttttcgg tttattttct gtttggttca tttggtgacc 1927021 tctcctaatt tgtactggct atccaaatcg tatgcaaatt caaagaagat gtcaacggtt 1927081 tcgattgctt cgtcagaaat tagacacact tcaaaggccg gaggctatta gccccggcct 1927141 gttaggttta cgcctctttt atcaaatgtt caatgacctt atgttcattt tcattcagca 1927201 ggttcttttg aattttcgaa tgaatgggtt tattcatatg ctgatccaag atatcggccg 1927261 tttctttatc cccggcaata accattcgtt cccatctttt cgcggcagct ttttgatcaa 1927321 ggctggcagc cagccgctta tacagtctcg attggttctc tgttacatgt tccctcatcc 1927381 ggttctcttc aaatggtggc gctttgtcta cagcggaatg gctattcttc caagactcat 1927441 tgatcatatc atactcataa cgctccaccg cctcaatttt tcctaaaaca gtttcaataa 1927501 ttttcacttc atgctgctga gttaaaataa acgccgtact tgggtatgtc tggcgcaaac 1927561 cctttagctg atccaggaca gctgtttctt cccagtaaaa tcttgtatct acagggactt 1927621 gaagcttaat aggttcccat atgccgctgt cggaaacaaa aaacacgaga ctgcggggca 1927681 tgtcttttcc cattgcattc aagtattgat tcattttagc cctgattcca tccagacact 1927741 tttcctcctc tggatcacta gctgccaaat actcttttaa tcggctgaat cctgacttta 1927801 gggcaatctt ccattctccc ccctgctgct ctggatctct catgtctgta ttgagataca 1927861 gagagagaat tttatccggc ggttccaatt ggacatactg taatttgtta atcaatgaat 1927921 caatcgccat tccgattcct cctttttcac aggttagttt tctttttcct ctcttaaaaa 1927981 cgatcaaacc tgactttccg ctaatttcta gtaataatgg aattgttgtt tacaatacgc 1928041 ctctcttcta atacaattgg taactgtgtt tctaagctgt tttttgaaag gagtttgatc 1928101 ttgtttactg ttaaagaaaa aaatcgtcaa gagcttgagg aagaactaaa tgatttagaa 1928161 tttcaaattt atcgcatgca ggagaatatg aaggatttat ctaaagatgc caaagtgctt 1928221 ggtattgatc aatcgaaaca tgatgagtgg atgattgttt cctcgattga tgatggccaa 1928281 acatgcaaaa ttatgctaac tgattgtaaa acggcatacc gaggaaaagg ctgtttttca 1928341 cttgtagcgt cttacaagga cgatgccatt catatagggg atataaaagg ccctccgaat 1928401 cacgggtttg gctccatttg catgaaatat ttaaaagata ttgcaagaga ccataatata 1928461 ccgaaagtca ccggagacat cgccaaacgg gattggaatc atgtagaccg gctgattcac 1928521 ttttatgaaa aacatcactt caaagtatgt atcgatcatg atacccaatc cggcagcatt 1928581 aagtgggttg atttgtaaaa aagtctggaa gaaagagcca agatatgctg taatggtata 1928641 aaaccattga tggagggttc tatgtacgcc tcaaaactga aaaagggaga cgaaatccgg 1928701 atcgtgtctc ccgcgaccag catgtctata ttatcaaatg aagcaaaaat ccaagcaaaa 1928761 acggcgttag aacgcttagg ttatcgggta accatcgctg aacacgcaaa tgaatgtaac 1928821 gaatttgatt catcctctat cgagtcaaga gtccatgatc tgcacgctgc cttttttgat 1928881 ccaggcgtca aagcgatttt aacgacactc ggagggttta attcaaatca gctgctgcgt 1928941 tatcttgatt acgagaaaat caaacgacat ccaaaaattc tgtgcggtta ttccgatata 1929001 accgctcttt gcaacgctat ttatcaaaaa acgggtcttg ttacgtattc aggtccccac 1929061 ttctcaacat ttgcaatgaa aaaaggactc gattatacag aggagtattt tctttcttgc 1929121 tgcgcttcag acgatccgtt tgaaattcac ccctcaagtg agtggagcga tgatcgctgg 1929181 tttttggatc aagaaaacag gcgtttttat cctaataacg gccctgttgt aatccaagaa 1929241 ggttatgcgg aaggtacttt aattggcgga aacttatgca cgcttaattt gctgcaggga 1929301 acggagtatt ttcccgaaac agaacatact attttattga ttgaagatga ttatatgtca 1929361 gacatccata tgtttgaccg cgatctgcaa tcactcatcc acctccccgc tttttcacat 1929421 gtaaaggcga ttttgatcgg cagatttcag aaagcatcaa acgtatcaat agatcttgta 1929481 aaagccatga tcgaaacaaa aaaagaatta tccggcatcc cgatcatcgc aaatataaat 1929541 gccggacata cctcgccaat tgccacgttc cctataggag gaacatgcag gattgaagct 1929601 atttcgggta catcacgaat atggattgat aaacattaat cagcttgtaa atttttttac 1929661 aagctttttt agcgcaatcg gctatgcatg ccgcacgaga catgacaaat gtcatatagg 1929721 aggcatgatg tgtgctacta caaaagactt ctctcattag cgtatactga accgagacac 1929781 acaatgagag gatacttact atgactgaac aaaccattgc acataaacaa aaacagctga 1929841 caaagcaagt cgctgcattt gctcagcctg aaacaaaaaa cagcctgatt cagcttttaa 1929901 acacgtttat cccattcttc ggcctatggt ttcttgctta tctcagcctc gatgtctcct 1929961 atcttcttac gttagcatta acggtgattg ccgcaggttt tctgacaaga atttttatca 1930021 tcttccatga ctgctgccat caatcttttt tcaaacaaaa acgctataac cacattctcg 1930081 gttttctgac aggtgtcctg actttattcc cgtatcttca atggcagcac agccattcga 1930141 ttcatcatgc aactagcagc aatctggata aacgcggaac aggagacatc tggatgttaa 1930201 cagtaaacga atataaagct gcatccagac gaacaaagct tgcatacaga ctttatagaa 1930261 acccgtttat catgtttatt ctcggaccga tttatgtttt tctgatcacg aaccgtttta 1930321 acaaaaaagg cgcaagacgc aaggaacgtg taaacacata ccttacgaat ctggcaattg 1930381 tcgcgttggc tgccgcttgc tgtctgatct ttggctggca atcgttttta ctggtgcaag 1930441 gcccgatatt tctgatttca ggttcaatcg gtgtttggct gttttatgtg cagcatacct 1930501 ttgaagattc ttattttgaa gcggatgaaa actggagcta cgttcaggct gctgttgaag 1930561 gcagctcatt ttataaactc ccgaaactgc ttcaatggct aacaggcaat attggttacc 1930621 accacgttca tcatttgagt ccaaaggtgc ctaactataa gcttgaagtt gctcatgaac 1930681 atcacgaacc attaaaaaac gtaccgacaa tcaccttaaa aacaagcctg caatcacttg 1930741 cgttccgtct atgggatgaa gataacaaac agtttgtgtc atttcgggct ataaaacata 1930801 tacctgtaag ccttccgcct gattcaccag aaaaacagaa gctgcggaag aatgcctgat 1930861 gataaaggag gtcttctaat atactagaag gcttcctttt tattgttgga gggtgcattc 1930921 tggctttcac aatgataaag ttacaagtaa gatgaaaagc tgaaaatgag gtaagatcat 1930981 gattaaaaat cattttacat ttcaaaaact aaacgggatt acgccctata tatggacgat 1931041 atttttcatc ctccccttct actttatatg gaaatcatca tctacatttg ttattattgt 1931101 cggcatcatt ttgacgcttt tatttttttc ggtatatcga tttgcttttg tctcaaaagg 1931161 ctggaccatt tatttgtggg gatttttatt aattggcatt tcaaccgcct ccattactct 1931221 gttcagttat atttattttg ctttctttat tgcttatttt attggaaaca ttaaggaacg 1931281 cgtccctttt catattttat attatgtcca tttaataagc gcggccgtcg cagccaattt 1931341 cagtctcgta ttaaaaaagg aattctttct gacacaaatt ccttttgtcg ttattaccct 1931401 catcagcgca attttattgc ccttcagtat aaaaagccgc aaggagcgcg aacgacttga 1931461 agaaaagctc gaggatgcaa atgaacggat tgcagaactg gtaaaattag aagaacgtca 1931521 gcgaattgcc cgcgatctcc atgatacgct tgggcaaaag ctttctctta ttggtttaaa 1931581 aagcgactta gcaagaaaat tgatatacaa agatcccgaa caagcagctc gtgaactgaa 1931641 aagtgttcag caaacagcgc gaacttcttt aaatgaagta agaaaaatcg tttcctctat 1931701 gaagggcatc cggctcaagg atgaattgat caacatcaaa caaattctcg aagcagctga 1931761 cattatgttt atctatgaag aagagaaatg gcccgagaat atctcattgc tgaatgaaaa 1931821 cattttgagc atgtgcttaa aggaagctgt cacaaatgtc gtcaaacaca gccaggctaa 1931881 aacttgccga gttgacattc agcagctctg gaaggaagtt gtgattacag tgtctgacga 1931941 tggaacattc aaaggagaag aaaattcctt ttcaaaagga catggcttac tcgggatgag 1932001 agaacggctt gagtttgcaa acggaagcct tcacatcgat accgaaaacg ggaccaagct 1932061 taccatggca attcctaata attcaaaata aacataaagg atggcttata tgattagtat 1932121 atttattgca gaagatcagc aaatgctgct gggcgcttta ggatcacttc taaacctcga 1932181 agacgatatg gaagtcgtag gcaaaggtac aaccggccaa gatgctgttg attttgtcaa 1932241 aaaacgccag cctgatgtat gtattatgga cattgaaatg cccggaaaaa cagggcttga 1932301 agctgctgag gagctaaaag atacaggctg caaaattatc atcttaacca ccttcgccag 1932361 acccggttac tttcagagag ctattaaagc tggcgttaaa ggctatttgt taaaagacag 1932421 tccgagtgaa gagctggcca acgccatccg tagcgtcatg aacggaaaac gcatctatgc 1932481 acctgaactg atggaggact tatacagcga agctaaccct cttacagata gagaaaaaga 1932541 agtgctcgaa cttgtggctg acggtaaaaa cacaaaagaa atcgctcagg aactcagcat 1932601 caaaagcggg acggtgcgga attatatctc aatgattcta gaaaagcttg aagtgaaaaa 1932661 tcgaattgaa gccattaccc ggtcaaaaga aaaaggctgg tttaaataaa aaaggatctt 1932721 ggcatctgcc aggatccttt ttgttaacct gaaattcccg tttgagaacc tcgtcgcaac 1932781 cagaattaaa ttgatccata tcctcgctcc tacgcccgct gaacgattgt ttggttaaca 1932841 gcccaataaa agactggatt gaatgatatc cctgttaaaa tggtcggcca ttgcacatca 1932901 gcagaatttc tgatattgat tatattgtat tttcagtatg acaaagttgt gccacttcgc 1932961 tcccgaagct gccatgccca actgcaagag cctaatatca caataaaaaa ccgtctgaaa 1933021 tcaatccgat tccgtaaatg gtatctgcta catccaactg cttattatct gccaaaaaca 1933081 ccagctcgtt tcgctgatca aagatagtaa caaccagcta taaatgtcat gatgccgaat 1933141 gtctctgtaa tgtggaatca atcttttaac ccgagagccc ctgaatcgca cataaagaaa 1933201 aacgggacca ctttctttta tcagcatatg atataaacag ctctaagcag aacaaaaaaa 1933261 gacacaagcc aaaagcttat gtcttttatc acaatctata ttattagttt aagactttaa 1933321 cacttacagt tttgacgccc caattagaag catcactttt acttggtaca aatacgtcga 1933381 ttttatttcc tttaatagcg ccgccagtgt ctgctgctgt tgcttccccg tagccttcaa 1933441 catagacttt agaacctagc ggaattacat taggatcaac cgcaataact ttcgcgttcg 1933501 ggttcttatt taagtcaatg cctgtagctg taacgccgga aatgccgccg tcgttagcag 1933561 tgtaagcagt agcagtaact gttagttctt ttgaagcttc ttgattattt gtatttgatt 1933621 gaacagcctt ctcctctgtg ttaacagaag tttctgcctc agcctttgtt tcttgtttag 1933681 gttgctgttg tacagcttct tgtttaggtt gctctttttg cacagcctct tgttttggcg 1933741 cagcttgagg tgcgtttgtt tgcgcattct cagtagctgt gtttgctgct gttgcctgac 1933801 cttttactga aagagttgat ccagcataga tcatgtcaga gcttaagtta ttccaaactt 1933861 tcaggttgtt gactgtcgtg ccgaattttt gagcaatctt agaaagcgta tctcccgctt 1933921 taattgtata ttgcccagtc gtggttgttt cttctgaaga aatggtcagt ttttctcctg 1933981 caatgatttt atcagaagtt aacttgttcc attcttttaa gtcctttagg ttcactccat 1934041 ttttctgaga gattccccag agcgtatcac ccttttgcac cgtaatttct tttgcagaag 1934101 cgtgagctcc gaatgcagtt gttgaaagtg cagcaactgc cacaaaggac ataatcgtct 1934161 tcttcataag taaatcctcc cttgttagct ttttattggc ggctaacagg tgatatcgta 1934221 acacacgtaa atgtcaaatc aataacaaaa agatatgatt tagattacag ttcctttaca 1934281 tgaaggattt ctctctgatg gaaagacttg ctgaaccctt gatataatag gcttcgcagg 1934341 tctttttatt ttgaggcgaa acagagaaaa taaaatgtgt tttttataga aaaaaagatt 1934401 gtttttctgt ttttttagtc tgtcatcctt gcataagcct gtatttcttg taaaaaaagc 1934461 cggccgtatt ttgctctttt ttgttctccg actcctttta tagacaaaag ttcatcatca 1934521 tttacgggct gttttcctga catttctttt aacgtttggt cagagaaaac aacaaatggc 1934581 ggaacaccct gctcagccgc aatttctttc cgaaccatgc gcaatcgttc aaatagctcg 1934641 tcattttcag taatcgctgc cgcttttaac gcttcttttc tcgctactga taattctcct 1934701 ttcagcacat tccttccttt actgctgaca aaaagagtcg gaaacgttcc gtctgacatc 1934761 ctgatgaagt cgtcagaaat aagaaattcg ataaaatcac tgatttcgcc aacggattgg 1934821 tgttttaata tcccgtatgt tgaaaggtcg gaaaagccgt tttcaagaac ttttttattt 1934881 ttggagccgg caagcacctg ggcaaccatc gtcttgccaa accgttcttt catgcgaatg 1934941 atacaagata agaccatttg cgcctcccgc gtcacgtcat gggccgctct tgtatcggta 1935001 cagtttccgc actgtccgca cgcatcaggc tccttttctc cgaaatacat aaggataaaa 1935061 cgctgcagac aatcttccgt atgacagtag tcgaccattt gtctcagctt ttttaaatcc 1935121 tgcttttgtt tctcttcatg ttctgattgc tcaattaaga agcgctgcac cataatatcc 1935181 tgcggtgaaa acaggagaac acattcactg gcaagaccgt cccgtccagc tcgtcctgcc 1935241 tcttgataat agctttccat atctttcggg atttgtgcat gcagaacaaa tctgatattt 1935301 gatttatcaa tacccattcc aaaagcagag gttgccacca tcacttgaag ctcatcatta 1935361 agaaatcttt cctgctgctc ttttctcaca tcatcagcca aacctccatg ataccggcct 1935421 gccctgacct gatttcgttt caatctctca tatatccgat cagcttcttt tctggtcgct 1935481 gtatagacaa ttcctgcttc atgcctgttg ttttgcacat attcgtctat aaaccgatct 1935541 ttattttctc cttttactac tttaaaggtt aaattctctc gggaaaatcc ggtatatacc 1935601 gtgttttctt tttgaatatg cagctgtttg caaatatcat catgaacctc gggtgtggct 1935661 gttgctgtta acgccatgat gacaggcttg tcgtgtaatt cacggaacaa gatttcaata 1935721 ttcctgtagc ttggcctgaa atcatggccc cattgagaaa tacaatgcgc ctcgtctatt 1935781 gcgaccaaag gaacatctat gccctgcaaa atccggataa actctatgga cgttagtcgc 1935841 tctggtgtaa tgtaaaaaag cttataagcc ccttctttga gtccgttcag cctctcatat 1935901 atttcctgat tggattgtgt gctgttaatg taggcggcgt taatccccgc ttcttctaac 1935961 gcatcaactt gatccttcat caaggaaatc aacggtgaaa tgacgatcgt cgtcccttca 1936021 aacattaatg ccggaatctg atagcaaatc gatttgccgc ctcccgtcgg cataatgcag 1936081 gccgtatttt gcctcgcttc cgtcaccaag cggatcgctt catcttggcc gctccgaaac 1936141 ttctcataac caaaataatg agccagaagg gattgggctc tatgtaacat aacgtgtaaa 1936201 cctcgctttt ccttgaattt ctcccatcat atcataaaaa agcggccttc atttctttca 1936261 cacaaaaatg gaatattcac tataccaaac ctttttagat aaaataaaaa gccatttccg 1936321 aaaaggaaat ggctttcgct acgtcttgcc gtatgcaagt aagaaagttt taaaccacca 1936381 ctcctcaaag tgggtgtttg cagaaacgtt cctgtcgtcc tctgcaatgg aggcatgaca 1936441 ttccggcttc gatataaaac tccctattac agcttaaagg ttaaaactta attaacaata 1936501 cgcacaaagt agcttcttta atatagtaca ccatcaggcg cttttaatca agaggtcaga 1936561 acaattgttt agaaaaactt tttccagtga ataaaactgt tttttctcca aaatacctga 1936621 caattcgaca aacaaaaaat atattacaat aaaaaaaata gcctttattg ctaaaagcga 1936681 atgattattt tcttctatat taatgtgtat atacaaaaag actcctattt gtaacgatag 1936741 gagtcttggc tttattagaa ttttgcagca agatcttttg cttcttgtaa acctttttca 1936801 acgatttctt gcgcttgatc aggtgctgcg ttatgtcctt cgatgacaac tgtgtgcaag 1936861 tcttgaacac cccagaaacc aagaactgtt ttcatgaagt ttaatgacat ttcaagtgca 1936921 gccattggtc cttctgagta gacaccgccg cgagcgttaa gaagcgcaac ttttttgccg 1936981 cccattaaac cgactggtcc ttcttgtgtg tatttgaatg taacgcctgc gcgagacaga 1937041 taatcaacat aagtatgaag cactgctggc actgtgaagt tccaaagcgg gaatgcgaaa 1937101 acaactttgt cagcttttac aaactggttc agatatttgt cagcaattgc tgcttgtttt 1937161 ttctcatctt ctgtcatttc cattccttga cctgctttaa atgttccgtt aatcatatct 1937221 ctgccaaggt aaggaaggtt ttccttatga agatctaatt caaccacttc atcattaggg 1937281 ttgttttctt tataagcagc taagaaagct tcgtaaagtt tagttgaaac gccttcttca 1937341 gctgtacggt cgcttgattt tacaaataaa actgtagaca tttgtattcc tcccggtaaa 1937401 ctttttatat ttacttacaa atagtatgtt actttctttt ttacgtaaag tcaatcactt 1937461 tattttgaat atgagatttt ttttcaaaaa aaagcaagta catctaatat cggtgtactt 1937521 gcttggcatt tttacttcga atcttgttca cgatccaaga tttcatacgt ctgcgagctt 1937581 ttttgatcaa ttgtttcttt gttggataag tcttttacct gttcatgaaa ctctctttca 1937641 taagaaggag catctgtctc cagatcatcc tccacatcag cttgggcctc aactgtcatt 1937701 cttgcataag gaacagcttc aagtctttcg taaggaatct cttggccggt tttttcacac 1937761 acgccataag ttccgtcttt catcttttgt aatgcacggt tgacctcctc taacagctcc 1937821 cggtcaatct ctttcactgt ttggtctgtc atccggtctg tgacgagcgt cccgtggtct 1937881 gccatatggt tgtcaacccc attggaaagc tcccccactt cttccgtcat tgattctgtt 1937941 tcctttttct cgccagacaa ttctttttgc atatcgagca atttatgata gagatgctgt 1938001 gtttgttctt ttgtcagtgc catgtatatc ctctcctttc tatcctgttt cccgttttgc 1938061 cttctgtcaa acatggaaac atcgatggaa agatgagcta ctgccttttt gaacggatcg 1938121 tgaccgctgg cgtcgatggt gcttcgggtt ttcgttggca ctttttgtcc ttctcttctg 1938181 gcggtatata ataggttgcg cctatattta atctgccgct cagttcatca atggtcagct 1938241 cgccgaattc aagatgatag tcaacttttt cgacattcag cgtttcaata tgtatatagg 1938301 tttcttcaga ctcttgtttg ctgctttgtt tttgtttctc aatcactgag agtctttctt 1938361 cacattcacg cagtttgtca agttctggtt tcaagcaatg cctgatcagc gaccggaaca 1938421 tttttttcat gacatcacga ccctttgcat actcctcttt cgtctacata tataatgagg 1938481 tatatcccat agaaaggaga ggttttcatg cttccgacta acatcaatat ttctcatctc 1938541 aagactaact cgataggcac cggctcatcc cttacctttg gttctgcgga gttaaggaac 1938601 aggtgctctg ctatcaaaag aaataacggt tttggggaac aaaatgcaga tggtattgtt 1938661 atggtcattc cgattgaatc aattgatgac cgtgatgtgt cagatgcact cagtatgaaa 1938721 atcaatcatc aataacaatg gttttcgctt gaccttcgtc tttttgaata gtgatgtata 1938781 ggattccgtc tttaaaaatg gcattcatct ttccatgaag atgatcggaa agcggaattt 1938841 tcttttcaaa acttccgtat ttcccttctt tttggcgaaa gtcctgttca ttaaaatagg 1938901 aaaagcgctg ccccttcacc actaaataat ctccgtacga taatatgtga acgtcttgtt 1938961 tacggtagcc tggaagataa attaaaaact gcacttccgc aacggtatct acaatatcca 1939021 tgctcggaaa tgaagcatct cctttccctc gctgatcttg ctgcgcaaac ggaaacggag 1939081 attggccatt tgtcataaaa ggggtttttt ggtcttcatc aaatacctgt ttccaaaagt 1939141 caccgccgta catctgctgt gcgaattcca tccactgctt catcttttcg aaatccattt 1939201 gaagccccct gtcttaacat actttataac cgccagcata caactataga aaggaggttt 1939261 gcctgtggtt caaccaactc cgtatatcaa tattaatatt ttcatgctga aaattaattc 1939321 ctttgaaaat gcttcagcgg ttaacgtagg acaaaattta ttggcagaat ggcaaaattc 1939381 agataaaaaa aatcaaggct acggacagaa ttttggagat gcgagcggat ttatgggcac 1939441 gagaagccat gtggatgaca gagaccaaat tgattctccg gcctcttttg aaagtgaagc 1939501 ggttaactcc tcaatcaaaa ggaagtgatg agatgttctt ttcaccctcc gtcgtaaatg 1939561 tcggcggatt taaaatcaat acgatggatc gaggttcctc tttaacactc ggtccgtatc 1939621 agcaggtcga ttacttttta tcagctaaaa taaatcaagg gtttggagaa gaaaatggcg 1939681 actttactcc tcttgtcgtg ccgatttcaa atgtattaga tgcagatctt gttgattcga 1939741 actcagcgaa aaacagtgtg gtgtaataag aacagggcgc acatgccctg ttcttgtttt 1939801 tatatataaa aaaagcctaa ccattttttg aacggctggc tcatcaaata ttcagctgca 1939861 caaatgcttt gtcagcaccg cctgaacctc gcttaaatcg gtgtctttcg caaattctaa 1939921 ttcgaaagtt ttgcttcttg tcatcaataa aagcccagtg tccggatcaa acattcccgc 1939981 ttcttggatg gcaaagcttt caattgtttt atatggaaga aatacacgaa ccttcttttt 1940041 agaaaacatt ttattgtcaa agaaaatgat ccgcttattt gtaaagcaaa tttggtccac 1940101 tcggagctta taaatcgatt caattctttc cccttcaacg agcaaagcct caagcttctt 1940161 tgcgtccgtt gatctgctaa cagaaaaaat acccaatgaa gaacccctct ttctgcattt 1940221 atctatttgt tttatcattc actacataaa aataagtcct ttatccctat ataagaatac 1940281 gacatagaag acatttaaac cattacgaac agattacatt tttcaaattt ttgatttgtt 1940341 ttttggcttt taagctgttg tcatcaagta atacgcacat atagagaaaa aagtttcaat 1940401 attcagcaat gtttttataa aaaagtggtt tttaatgatt tttttaattt tgttttatat 1940461 ttcctgtttt aaccacaaaa aaaccgcagc tgagctgcgg ttttatgtat cgactgcttt 1940521 taacaaaatc tgtttgatgc ttcaaggaag cattacatct cttcgaagta ttctttataa 1940581 tagccgccga ctttattcgt attgtcgacc acaaagagaa actcctctgt ttcatttttt 1940641 acttcatatt cttttcccgg cgttaaaacg cggtttacga tatatttttt tgcgtttgtc 1940701 tgcacacact ttactttttt aatggtttct ttttcaagcc aatttttatg aatcatgatg 1940761 aaatctcctt ttcttatcta taagcttatt gtagcttttt tcttttgtaa attgcaatat 1940821 cggttattca ttgattttgc cttgatttct attatagaat gtttgtatac gcttacgttt 1940881 gaagcaacta tcacagctta tttctgctat tcaatccagg aatcaatgtg ctatcaccaa 1940941 gaatctcaga acagaccata aaaaatgact ggaggtttgt tacggatgag ttctttaacg 1941001 atgcaagtga cgaaaaggct ggagacattt ttacagggaa caaagaagct ttatattgac 1941061 ggaaagtttg ttccgagtgc ctcaggggca acctttgaca ctccaaaccc ggcgaccggc 1941121 gaaaccttga tgacgctgta tgaagcccag gctgcggatg tggacaaagc tgttaaagct 1941181 gcccggaaag cctttgacca aggtgaatgg agaacaatgt ctccagcttc gagaagcaga 1941241 ctgatgtata agctggcaga cttaatggaa gagcataaaa ctgagcttgc tcagcttgaa 1941301 acacttgata atgggaaacc gatcaatgaa acgactaatg gagatattcc gctggctatt 1941361 gagcatatgc gctattacgc cggctggtgt acaaaaataa caggacagac gattccggtt 1941421 tccggcgctt attttaatta tacgcgtcat gagcctgtcg gtgtcgtcgg ccagatcatt 1941481 ccatggaatt tcccgctcct gatggcgatg tggaaaatgg gcgcggcact tgcaacaggc 1941541 tgtacaatcg tcctcaaacc ggctgaacaa acaccgcttt cagctcttta tttggcagaa 1941601 ttaattgacc aagccggttt ccctgccggt gtaatcaaca tcatcccagg attcggtgaa 1941661 gatgcgggag aagcgctgac gaaccacgaa gcggttgata aaattgcctt taccggttcc 1941721 actgaaatcg gaaagaaaat catgtccacc gcagcgaaaa gcattaagcg tgtgacattg 1941781 gagctgggcg gaaaatcgcc taatattctt ctgccggatg cgaatttaaa aaaagccatc 1941841 ccgggcgctt taaacggtgt gatgtttaac cagggccaag tctgctgtgc gggctcacgt 1941901 gtcttcattc ataaagacca atatgatgaa gttgttgatg aaatggcatc ctatgctgag 1941961 tcactccgcc aaggagcggg acttcataaa gatactcaaa tcgggcctct cgtaagcaag 1942021 gaacagcatg agcgcgttct ttcctatatt caaaaaggaa aagatgaagg agcaaaagca 1942081 gtgaccggcg gaagctgtcc ttttgaagca ggatattttg tcgcaccgac tgtgtttgcg 1942141 aatgttgaag acgaaatgac catcgcaaaa gaagaaattt tcggacccgt gctgactgca 1942201 attccgtacg aaacagtcga tgaagttatt gaacgggcaa accattcaga atatgggctt 1942261 gcagccggac tatggacaga gaacgtcaag caggctcact atatcgcgga ccgacttcaa 1942321 gccggaaccg tttgggtcaa ctgctataat gtgtttgacg cggcgtctcc atttggcggt 1942381 tataaacagt caggactcgg acgagaaatg ggatcatatg ccttggataa ttacacagaa 1942441 gtcaaaagtg tatgggtaaa ccttgaagac taacatgtat gtttaaaaaa ctgctgcctg 1942501 ccagcagttt ttttctttct gtaatggcag taaaagacgc tgaatatata tgcttctgaa 1942561 ggagttgagc gtgatgggca cacttcagga gaaagtgagg cgttttcaaa agaaaaccat 1942621 taccgagtta agagacaggc aaaatgctga tggttcatgg acattttgct ttgaaggacc 1942681 aatcatgaca aattcctttt ttattttgct ccttacctca ctagatgaag gcgaaaatga 1942741 aaaagaactg atatcatccc ttgcagccgg cattcatgca aaacagcagc cagacggcac 1942801 atttatcaac tatcccgatg aaacgcgcgg aaatctaacg gctaccgtcc aaggatatgt 1942861 cgggatgctg gcttcaggat gttttcacag aactgagccg cacatgaaga aagctgaaca 1942921 atttatcatc tcacatggcg gtttgagaca tgttcatttt atgacaaaat ggatgcttgc 1942981 cgcgaacggg ctttatcctt ggcctgcttt gtatttacca ttatcactca tggcgctccc 1943041 cccaacattg ccgattcatt tctatcagtt cagctcatat gcccgtattc attttgctcc 1943101 tatggctgta acactcaatc agcgatttgt ccttattaac cgcaatattt catctcttca 1943161 ccatctcgat ccgcacatga caaaaaatcc tttcacttgg cttcggtctg atgctttcga 1943221 agaaagagat ctcacgtcta ttttgttaca ttggaaacgc gtttttcatg caccatttgc 1943281 ttttcagcag ctgggcctac agacagctaa aacgtatatg ctggaccgga ttgaaaaaga 1943341 tggaacatta tacagctatg cgagcgcaac catatatatg gtttacagcc ttctgtcact 1943401 tggtgtgtca cgctattctc ctattatcag gagggcgatt accggcatta aatcactggt 1943461 gactaaatgc aacgggattc cttatctgga aaactctact tcaactgttt gggatacagc 1943521 tttaataagc tatgcccttc aaaaaaatgg tgtgaccgaa acggatggct ctgttacaaa 1943581 agcagccgac tttttgctag aacgccagca taccaaaata gcagattggt ctgtcaaaaa 1943641 tccaaattca gttcctggcg gctgggggtt ttcaaacatt aatacaaata accctgactg 1943701 tgacgacact acagccgttt taaaggcgat tccccgcaat cattctcctg cagcatggga 1943761 gcggggggta tcttggcttt tatcgatgca aaacaatgac ggcggatttt ctgctttcga 1943821 aaaaaatgtg aaccatccac tgatccgcct tctgccgctt gaatccgccg aggacgctgc 1943881 agttgaccct tcaaccgccg acctcaccgg acgtgtactg cactttttag gcgagaaagt 1943941 tggcttcaca gaaaaacatc aacatattca acgcgcagtg aagtggcttt tcgaacatca 1944001 ggaacaaaat gggtcttggt acggcagatg gggtgtttgc tacatttacg gcacttgggc 1944061 tgctcttact ggtatgcatg catgcggggt tgaccgaaag catcccggta tacaaaaggc 1944121 tctgcgttgg ctcaaatcca tacaaaatga tgacggaagc tggggagaat cctgcaaaag 1944181 cgccgaaatc aaaacatatg taccgcttca tagaggaacc attgtacaaa cggcctgggc 1944241 tttagacgct ttgctcacat atgaaaattc cgaacatccg tctgttgtga aaggcatgca 1944301 ataccttacc gacagcagtt cgcatagcgc cgatagcctc gcgtatccag cagggatcgg 1944361 attgccgaag caattttata ttcgctatca cagttatcca tatgtattct ctttgctggc 1944421 tgtcgggaag tatttagatt ctattgaaaa ggagacagca aatgaaacgt gaatcttatc 1944481 aagcggagat gttcaattgg tgtgaagccc tgaaagatca gattcaaaag cgaggtcagc 1944541 ttgaccagtt tgaagatcaa atcgacaaga tgattgaggc tctggaagat gaccaaacaa 1944601 cagaagaaga ttggtataaa caggccgctg ccctttatcg ggatattaca gaatcagatg 1944661 atacaagtga aagacgcgct tatgtcccta tagggaaaca cgtgctgcca aagcttcctt 1944721 acaaatactc cgccttagaa ccttatatat cacgcgatat tatgatcctt catcatacaa 1944781 aacatcatca aagctatgtc gatggcctga acaaagcaga atcagagctt aaaaaagcga 1944841 gagcgacaaa gaattatgac ttaatcactc attgggaaag agagcttgcg ttccatggag 1944901 caggccatta tttgcatagt attttttggt tttctatgca tccaaacgga aaacggcgtc 1944961 ctacaggggc attgttccaa atgatagacc tttcatttgg aagctattcc gcttttaaag 1945021 aacattttac ccaggcctct aaaaaagtgg aaggcgtcgg ctgggccatt ctggtctggg 1945081 cacctcgatc aggacggctg gagattttaa cggcagaaaa acaccagctc tttagccaat 1945141 gggatgtgat ccccctttta ccgcttgacg tatgggagca tgcctactat ttgcaataca 1945201 aaaatgaccg ggccagctat gtcgatcact ggtggaatgt cgtggattgg cgcgaggctg 1945261 aaaaacgttt tgagcaggca aaagaagtcg tttggaagct ctattaaaaa aagccccctt 1945321 tcctcggggg cttcgtgtgt taaaaaatac ctatcacatg caaaaacacg atgatgatgg 1945381 caacaggaga tagatatcga atgagcagca gccaaaccgc aaaccacttt cgtttgagat 1945441 tggaaccgct tttcagctcg tcaaacaaat cctgtttcgg tatttttagc ggaacaaaaa 1945501 tcgaaatcag taacgcacct aacggcatta aaatattgct cacaagatag tcagccgcat 1945561 caaaaataga cagatgaaat atagtgacgt cacttaagac accgtatgat aatgcagacg 1945621 gcacaccgac aataaaaata gcaataccgc ctaaccaagc gaatcgtttt ctcttattga 1945681 tatcgccttt cgacagtact gcgaccaaaa tttccagcat tgaaaaagca gatgtcaatg 1945741 cagcaaataa aaatagaagt aaaaatgcta ataaaaagat aattccgaac ggcatttgat 1945801 taaacacagt cggcagaacg ttaaataaca gaaccgggcc ttggtctggc ttgaggccga 1945861 atgaaaatac agctggaaaa atcgcaattc cggccattac agcaacaagc atgttcataa 1945921 cagttacaga tacagcggac tgtaccagat tttcctgttt ctctaaataa gcgctatacg 1945981 ttaccatgac agatacaccg acacttaata agaaaaagga ttgtcccatt gcatataaaa 1946041 tggtattggc atcaattgca gttaaatcag gcatgaggaa aaatttgatt ccttccatcg 1946101 cgccatcaag tgtaaccgaa cgcaccatta aaatgatgaa taatagaaaa agcgccggca 1946161 ttaatacttg gcttgctttt tcaattccgc tgcttacccc ttttgcaaca actaaaattg 1946221 ttaccaccat aaagagcagc tggcctccta cagccaaata aggatttgaa atggtacttg 1946281 caaatatcgt atcaaaacca gatgtttgcg ataaaccgcc agtgaagcct tttataatat 1946341 aaattaaaat ccatccgcct acgacactgt agaaagatag aagaataaag cacgtcacca 1946401 tgcctaaata accgatccaa tgccacttcg ttcctggagc aagtgtttta taggactgaa 1946461 cggcatcttt ctgtgttctt ctgcctatga tgaattcacc taacaataaa ggcagtccga 1946521 ttaaaaccgt aaataaaata aaaataagta aaaatgcgcc tcctccgctg gttccggcaa 1946581 catatgggaa tttccatatc gcaccaagcc cgatagctga tcctgccgcg gctaaaataa 1946641 agccgagctt cgaagaccat tgatttgctt ccttcaccgt atcactccta tttgatctaa 1946701 ccattataaa ggttcattgt aagaatatct tcctatatag tcaagaacat tttaattagt 1946761 ttacatcata tatctataga catctgccaa aaactaatat tgaattattc agaaaattat 1946821 ttataataag agaatgttat gaaatttgta agaatttctg ctgaagttct tgataagtgt 1946881 gttaggagtg tttttatgga catcattaga aaaataagcc attttgcagg acaaaccttt 1946941 ggcatatggg tcattgtttt tgcagtgctg ggattttctt tcccatcttt atttacgtgg 1947001 atcagttctt atattacgat ttttctcggc attatcatgt ttgggatggg ccttacactg 1947061 caagccgatg atttcaaaga gctggtcaga aagccttggc aagttattat tggagtaata 1947121 gctcagtata cgatcatgcc gctcgttgct ttcggcctcg catttgggct tcatcttcca 1947181 gctgaaatcg cagttggtgt tattcttgtc ggctgctgtc ccgggggaac tgcatctaat 1947241 gttatgacat tcttagcaaa aggaaatact gccctttctg ttgcggttac gacaatttct 1947301 accttattgg cacctgttgt aacaccgttg ttgattatgc tgtttgccaa agaatggctt 1947361 cctgtctcgc cggggtcttt gtttatctca atcttacagg cggttttatt tccgatcatt 1947421 gcaggtctga ttgtcaaaat gtttttcaga aaacaagtgg caaaagccgt acatgccctt 1947481 ccgcttgttt ctgtcattgg catcgttgcg attgtctcag ctgtcgtcag cggcaatcgg 1947541 gaaaatctgc ttcaatcggg gttgctcatt ttttcagttg ttatcctgca taacggtatc 1947601 ggttatttac tggggtttct ttgtgcaaag cttttaaaaa tggattaccc gtctcaaaaa 1947661 gcgattgcaa tcgaagtcgg catgcaaaac tccgggcttg gggctgcact tgccacggct 1947721 catttctcac cgctatctgc cgtaccaagc gcaatattca gtgtgtggca taacctttca 1947781 ggttctatgc ttgcaacata ttggtcaaaa aaagtgaaaa agaagcaagc tggatccaaa 1947841 agcagcaatc tatcacttta aatatgcatc aaaaagggta catcacttta tcgtgatgta 1947901 ccctttttta ttatccttct aataaaagct gttcaggatc ttccagtaaa tttttgattg 1947961 tcacgaggaa accaaccgct tctttaccgt ctacaattcg gtgatcataa gataaagcga 1948021 tatacatcat cggacggttt tcgaaacgct cttcatcaat ggctacaggg cgcagctgaa 1948081 tcttatgcat gcccagtata ccgacttgcg ggctgtttaa aattggagtt gacatcaatg 1948141 aaccgaaagt ccctccgttt gtaatcgtga aggagcctcc ctgaagctcg ctaagggtta 1948201 atttattgtt tcttgctttt ttcgcaagct cgccgatctc tttttcgatt cctgcaaatg 1948261 tcaggcgatc cgcatcccgt acaaccggaa cgacaagacc ttcatcagca gcaacagcga 1948321 ttccgatatc gtagaatttt ttaacgatca actcatcgcc ttgaatttct gcattcaaca 1948381 gcggatattt tttcaatgca gccacgaccg ctttcgtgaa gaaagacata aagccgagct 1948441 tcacttcatt ttgctcaaaa aattgatctt tgcggcgttt tctgagattc atgacagccg 1948501 tcatgtccac ttcattaaat gtagtcagca tcgctgatgt ttgctgtacc tctacaaggc 1948561 gttttgcaat cgtttgtctg cggcgtgaca ttttttgcac ttcaacaggt ttgtcaaagc 1948621 tttgctgtgc tttttgagcc tgaggctgct gcttttgctg aggagccggt tttgatgccg 1948681 gtttttcgta cgcttcgaca tcctgcttgc gcactcttcc aagcggatct ccagttggaa 1948741 cttgagacag gtcaattcct ttttctctcg caagcttacg ggccgacgga gaagcgatcg 1948801 ttcttgattt tgcttcagat tgtgcttcct cgctcacctc ttgtgcagct ggttcagcct 1948861 gtttctcttc ttttacgctt tccttgcttt ctgttttctc tgtaggagca ggggcagaac 1948921 tttcacccgc gccttctgaa atcgtaccga taatttctcc gacctggacg gtatcacccg 1948981 aatctttcaa tacctcttga agtacacccg attcttctgc tgtcaattca acattcactt 1949041 tatccgtttc tagttcaagc agatattcac cctgttctac atagtcacca ggctgcttta 1949101 accattgggc tattgttcct tctgagattg attctgctaa ttcaggtacc ttaatttccg 1949161 ccattttttc atttccccct tagtttttgc gagtcaagct atcagataca atacgttcct 1949221 gttctttttt atgaactgtc ggatctccct ctgcagggct ggatcgtctt cttcgtccaa 1949281 tatattgaac gcttactccc tctggtgcaa tctctgtcaa atacgggctg atataacccc 1949341 aagcccccat gttctgcggc tcttcctgca cccaaacgat ttctttcagg ttcggaagtt 1949401 ttgcaaataa ttctttgact ccttttgccg ggaatggata cagctgttcg attctcgcaa 1949461 tgtgaagcca ctctttaccg tcttctaact tattaaaatg atcgctaatg tctatagaca 1949521 ctttaccgct ggataataca agtctggtta ctttttcata gtcatgagaa agtcccgact 1949581 gttcataaac aggctggaag cggctttcgc tgagctcctg cacttccgac accgtatttg 1949641 ggttgcgaag aaggctcttc ggcgtcataa tgacgagcgg tctgatttct tcacgaagca 1949701 gcattttagc ctgtcttctt aaaatatgga aatactgtgc cgcgcttgtc aggttggcaa 1949761 ccgtccagtt gttttccgct gcaagctgca ggaatcgctc aattcttccg cttgagtgct 1949821 caggcccctg tccctcgtaa ccgtgcggga gcagcatgac taatccggat ttttggcccc 1949881 atttcgcgcg tccggcagaa ataaattggt caaaatacac ttgagcagcg ttggcaaaat 1949941 ctccgtactg tgcttcccac aaaacaagcg tttccggtga atgcacgtta tagccgtatt 1950001 caaaaccgag aaccgatcct tcagacagcg ggctgttatg aacagcaaat gatgtgctgc 1950061 agtcagataa gtgatgaagc ggcacaaatt ctttgcccgt ctcactgtca tgaagcacaa 1950121 ggtttctttg ggcgaacgtt ccgcgctcgg aatcctgtcc tgttaaacga atcggtgttc 1950181 cgtctttcaa aattgaagca aacgcgagtg attctgccaa agaccattcc acttttctgt 1950241 catcatcgaa cgccttggcg cgtctttcta aaatgcgctt tagcttgccg aaaacattaa 1950301 atgactccgg ccagttgatc aattcgccat tcagcttgcg gagcacatca aaatcaatcg 1950361 aagtgtccac atctgggaaa ccgtttgata caggctctgg aagttcaatt tcacaagcag 1950421 tgtgttcctt tttagacgga actttctgat atgcatcctc aatgcgcttc gttaccgatt 1950481 tttcgatgtt ttgaacgact tcctcggtaa ccacgccttc ttttaccagc ttttcagcga 1950541 aaatttgttt gacggtcgga tgctttctga cagcatcata cagcattggc tgagtggttg 1950601 acggttcatc catttcgttg tgtccatagc gtctgtaccc gatcaaatca atcagaaaat 1950661 ccttgttgaa tgtttttcgg tattcgaccg caaacttaac agctgaaaga caagcttcag 1950721 gatcgtccgc attcacgtga acaatcggaa tttcataacc cttggccagg tcgctggcat 1950781 attttgtcga tctggattca gcgctttctg ttgtgaatcc gatcatgtta ttggcgataa 1950841 tatgaatcgc accgcctact tgataccctt ttaaagagct taaattcaat gtttcagcta 1950901 caattccttc cccagggaat gcagcgtctc catggattaa aatggccagc gattttgttt 1950961 catcttgtac cgggtatccg ctttgtgttc gcgtttcctg tgccgctctt gtgctgcctt 1951021 caacaatcgg attgataaat tccaagtggc tcgggttgtt cgctaacgta atgcgcgctg 1951081 attttgtttc agcgtcttga agctcccgat tcgcccccaa atggtatttg acatcccccg 1951141 tccatccgta gctgattcca atggatccct cagacggtac aagatctttg ttcggcgcat 1951201 gctggaattc agagaagatg atttcatacg gtttgccgag cacatgtgcc aagacattca 1951261 ggcgtcccct gtgcgccatc ccgatgttga cacttgtcgt gcctgatttg acagattgtg 1951321 caataatgtc atcaagcact ggaacaagag cgtccagacc ctcaatggaa aagcgcttct 1951381 gcccgacgaa tgtgcggtgc aaaaactgct caaagccctc tacttctgtc aatctttcca 1951441 gcacagctga cagcttttca gctgagttct tctggaacag ctcgccagat tcaatctttc 1951501 ttgtcagcca ctcgcgctct ttgaagtcat gcacatggtc aaattcaaaa gagatggttc 1951561 ttttatacgt atttcgtaaa tactgaatgg cttctaaacc gttcgaaatg tttttaggag 1951621 cgtctttgca gatgacagac gcaggtattg cttttatttc ctcttctgtt agcccgtaat 1951681 cggataatgg aaaaagttcg ctctttttct catcctttct gagcggattg acggaagcgt 1951741 tcaaatggcc ataggttcgg atatcttctg caagtctgac tgcggatgcg atcttttgaa 1951801 tcagatcggc tgtaacacgt cccttttctt ttgttcccga ggcctctttt atatcgcttg 1951861 gcggagcacc gagctcgtcg aacatttcct tcaaatccgg gtcaatgctg ttcggatcct 1951921 gggtatactg atcgtaaagc tccagcgcat agccgaggtt cggaccgtaa aaatcttccc 1951981 aattcattcg ttgtttcata ctattttgaa acatttgaat attaccccca acttaaataa 1952041 tcaagtgatt gattcactat cttgaaataa ctttcgaacg ctgtgtccaa aattatgtaa 1952101 taaaaacgct tccaacgata ttttaccact gtttgcaatt tgattctacc ttgattgttc 1952161 acaaaatagt aaaaaacctt tataaaaaac aaaaaattta atcattcgaa aaaacaaacg 1952221 ccaaaaagca taggattaag ggctatccta tgcttttatg aagcagtttt ttcagcagcg 1952281 gatacaaaac atccggtagc tgatcaacat ccgggacaaa tatactgaat tttccgtaca 1952341 tatcctggat cgtcttcatt tgcgattctt ctatttctga gttggagaga aaaacattta 1952401 tcacttctat tcctcttttt cgggcttcga taaccgcctc acttgtatca acgatcccat 1952461 tttgttcgta gccaaatgcg gccggctctc catctgagaa aacaattaag aacttttgcg 1952521 cctcgctgcg atgcagcatt tttttcgtca tctgcctaat tgcgtacccg tcacggttat 1952581 cttcttctgg ctcaagctgc ataatggccg gtccagaatc ttgtcttaat gatgattgga 1952641 agggaataac cgtattgaaa tagtttggct ggcttttttc ggttgcatca tttgtgtcct 1952701 cccaaaaacc gacaatctga tgcggaaccg ctaccgattt caacgcttcg tgaaacagca 1952761 cgattcctcg ttttgtttcg tccattttgt cgaacatgct ggcggaacaa tcgaccagca 1952821 atgtaaaaac tgcgtcgatt tctgaagatg gttcttgctt tttgtagaac aggcgcggat 1952881 ttcgctcagt gaagtaacga agaagcttat tgttcagtct cccggcatga aggtctgttc 1952941 tcggcaatgt ttttttatgc tccagcgttt tttgaatcat ttgtttcaaa cgcttttgat 1953001 acgattcaat cgtttttgcc tgctgtttat aagaaagctc ttcttcactg gttgccggct 1953061 gcggttcttt ataaattgga aatgcatatt tattttcttt gccgtcagcc atacccgctc 1953121 cgttcggctg gtctttttgg gactccagcg cttccagctt ggaatagtct ttccgtttcg 1953181 tttgtctggc tgatccttga acagagccaa gggcctgatc tccatcgtcg ccttcccttg 1953241 aagcatcttt tcctaaatct gattttgcgc cgtgttcaat atcaaattga aggaagcttt 1953301 tagacggtgc ttctgtttcc cggtgccatg tcggcatttc ttcttcatgg atatcctcat 1953361 caccgtctga ttgttttgga agcgtgatgt catcactcag cttcggcgct tttttctctt 1953421 cttcaaataa cggctgttct gcagcttttg cgtaatcaag ctcaggcaaa aagaagtagg 1953481 tgttcaacat gtctttatcg agtacctctt caagtccgtc catgaggtcc tcaacaattt 1953541 tcagaacctg ccgtgtcgaa tctgcttcat acacacgcaa gagctgctgc tcaataaacg 1953601 ggcgcatcag atcgatatct tcacgcatgg atggaagggt ctcgagcggc gattccgctg 1953661 tgagcttgaa atagatcgcg caaaagagcg catcggtaaa aatgcttcgt tccaaattta 1953721 aggtcagctg ggttgagaaa tgttttctgt acatgtcttt tcgcttcgca aatacatgtt 1953781 tcgtacccgg gcgctcacgt ttgatgcatt cttcgatcct aatgtcttca agcagcataa 1953841 agagctgctt ggcaaaactt ttaaacgtaa gatggcgatg gatatcattc aaaaagttcg 1953901 caaactcatg cagcgagcta tatcttgttc cgactgaacg caggtagacg tcgcttttca 1953961 gacccgcttc catgtcctca gctgccctgt ctttccaaaa gtggctcata tagattttct 1954021 tttcaaatgg attgtaatag gactgaacgc catactccac ttctaccgct tcactcttgg 1954081 tgagtgtttt ggccaaatca gtcagcatca taaataaaaa tgaatcaatc gtgctgtcgt 1954141 taaatttgat aaatttcatc gcagccccct cattcaaaca gagtttctgc aatatttcgg 1954201 acagccgctt tttcccgatc atcatcaagc ttttctacaa ttccccgctc aatggcacga 1954261 cgcggcggaa tataagcagc taaatcacat gtatcgatta aagctctgat ggatgccgct 1954321 tcttcagaca cctgtccgtt attggcctga acgatcaagt cagaggaaag cgtgataaat 1954381 ctgtcaatca atttctcgtc tttcaaggct gactgagaca tgagcacttg tttcagcagc 1954441 tcgcctttaa tataaggcac atcaatgatg acaaaacggt ttttcaacgc ttcattcaga 1954501 ggaacagttc cgacatagcc ttcattgatg gctgcaatga ctccgaaacc gcttttagcc 1954561 cgtatgacct cgcctgtaaa cggatttgtc atcatttttc tgtaatctaa tacaccgttt 1954621 agaataggca gtgtttccgg cttcgccata ttgatttcat ctatataaag aaaatggcct 1954681 tccttcattg cctttgtaac aggtcctgaa acaaactcga ttgttgcctg gccagattga 1954741 ttttcaatcg ttttataacc gaccaatgcc tcagcgtcca agtcgactga acagttgacg 1954801 ctgtgcatcg gtttatgaaa atagctggac aatgtttctg ccagctttgt ttttcctgaa 1954861 cctgtaggcc ctttcagcag gacatttttc cccatggcta atgcaataat ggcgtcaaat 1954921 aaaatggctt catcctccgc ctcatagcct gatgttccta taagcgattg aaactctggg 1954981 gaaataggct gctctttata tgataaaagc ttttgttgta tatcttccgg caatgttaag 1955041 tgctgtagtt gagttgtcat agacagattc cctttcctat tcatattcca ttaacgagta 1955101 tactaaaaaa gcccctgtat gctcaataca aaagggcctg gatgatatta ctgcttctcg 1955161 ttatttccca aaagggctcc gcagacaata cgcgcaccgg aattgccgct tgggtttgtc 1955221 agataatcgt ccgcttgttc atgaataata aatgcacttc cgtcctcgtc gagaatattt 1955281 agtttacttc cttttttcag tgaagtgtca ggcgcattca ttatgacatc tacctttcca 1955341 tcagcaccga cttcaaggtt cggcagatct ccggcatgat gccccatcgg attattaaag 1955401 ccgtgttctt tgttcagtgg attaaaggga ccgcccgctg attcaaaatc cggcctgaca 1955461 caagaacctt tctcataaat atgaaaaccg agagaagcac ctggacgcag gctgtttgcg 1955521 gaaatatgaa tatcgaggcc ttcatcatct gattctttga tctctataaa accgactgct 1955581 ttcccttcac gattgaccag ctggacatga tgaccaaacg ctgacgtttc aaccactttt 1955641 ttttccggca cccggttagg agggtctgga ggtttttttt gtccgcatcc ggcaactccc 1955701 agtgccgtca gcatcatcaa cagcaagaga cggtgcatac tgtctccccc ttgttttttc 1955761 taacagtgtg gtcaatcatt gtctggtata aacaaaaaag cctataaaag gctttttgtc 1955821 atactcattt ttaaaaataa cttcttgcgc ccaagtaccg ctgtttccaa tacgaattgc 1955881 tgagattgga aatgtcgacg cccgatgagc ttgcatgaat aaaatcaccg ccgcctagat 1955941 aaatccccat gtgagacggg ccggatttat atgtggtaaa gaagacaaag tctcctactg 1956001 acggctggct gactttctgc atgacattcc aataccctgc cgtactcaat cttgatatag 1956061 atgatacatt attaatgagg taataaatga agccgctgca atcaaaaccg gcaggcgtgt 1956121 ttccgcccca tcggtaaggc actccgacat attttttcgc ttccgttatc attctgtcaa 1956181 tcttcgaacc tatttgaatg tttgaccctg agttatcttt tggctttgtt ggctttgtcg 1956241 gatttgaagg attagatttt gatgctcccg aaatagtcag aacctgcccg atttgcaaca 1956301 catccgatga taaattgttt ttatcacgga tgctttggac agtgactccg agccgatttg 1956361 caattttcca cagcgaatcg cctgctttta ccttgtacgt cgttgttttt gagggattgg 1956421 agtttgacgg ctttttggaa ccgctgtttc cgttcttagg tgaactgctt ccttttattt 1956481 tgagcacctg tttaggataa agtgtatctg atgttaagcc atttaaggtt tttaattcgg 1956541 ctacagtcat atttaagctg tttgcgattt tccacagtga gtcaccaagc ttgaccgtat 1956601 atgtactttt tgaagaacct gaagaattgg aaccgctgtt tttctttgat ccatttgatc 1956661 cgcttgaact gcttgtccct ttgatcttaa gcttttgccc cggacgaatc aggtcactgc 1956721 tcaggctgtt taagctttta agctcagaaa cactcatttt atgattttta gcaatcatcc 1956781 atagggaatc accatatgca actgtgtatg ttgatgtttt gcttgaatta gatggggatg 1956841 tcgtgctttt tttgctgctt tcaggaacct taagactttg tccgacataa agcaccgttg 1956901 atttcaattt gttttcggat ttcagagctg atattgtcgt atcatactgg cgggaaagtt 1956961 tccaaagaga gtcaccgctt tttactttta tcgtttttgc ttccgcgggt gctgcggcca 1957021 tcgacgaccc aacaactgca gaaacagcca agccggctac aatcttcttt ttcattcatt 1957081 caacctccta aactgttttt ttgcaaaaac agctagtatt ttgtttccaa aaatggcaca 1957141 caactgtttt atcgtcaatt tttcagcaag ttaaaccctt ttcaaacatt tggcgcagca 1957201 ttttcagcat cgttcgacct ttaaaccttc aaataaacat ctaacatttt acataagcac 1957261 gatatgtttt tcgaaagtct aaggaactat ttaagcgagg gtaaaaatga tggttttcta 1957321 ttgatgaacg aagcagtttc tcctcctttc ttgtctattt ttctaatcaa ttctctatcg 1957381 gcgtgtcaaa tcccttcctc tgcattctta tgaaatggca aaaagcctgt tctttcgata 1957441 agaacaggct tttacactat gcatttgctg attgagtttt ttgttttaca gcttcaagaa 1957501 tgctgtcggc tgctttttta gagccgcctg ccgctttcag tgattgtcca atttcttttg 1957561 ccttttcagc atacgaacga ttattcatta cttcttgtat cgtctctttc agtaggcttt 1957621 cagacaattc ttccttttta attacttttc ctgcgccgac tttttctacc tgatctgcga 1957681 caacaaattg gtcgcctccc atcggaatga caacgagcgg ggtttcaaaa tacaaacctt 1957741 cacttgtgct gttcattccg ccgtgggtca caaataagct ggctcttttc aagatctcaa 1957801 gctgagggac atacgggcgt acaatgaaat tctccggaat gtcgtttaac tcacttgttt 1957861 taatatgctt gccgatggaa agcacaactt taccgtcaaa gtccttacac acttcaaggc 1957921 attgattaaa aaactgcttt tgattattaa aaatggttcc cattgaaata aacagcacgt 1957981 tttcattgtc aatctgatca aatgggaaat cattgtttcc ggctctttct gtaatggaag 1958041 gaccgacaaa tacatatcgc tcgccaaatt gctcagccag tggctgaaat ccccttgatg 1958101 taaagacgat tgtcaagtca ccatcagcta aaaaaacatc aaatggcttc ttgatctctg 1958161 cttgaaaatc agcatttaac gtttctgcaa gctgctggta tgattcataa tgaggcgaat 1958221 cttcaagtga tcctttcatg tacgctccca tcatttcctt cgcaaattcc tcattcatcg 1958281 caaaggttgt acacaatgaa aatcttggca gcttcagcat gttggcaatg actttacccg 1958341 cgagaagatg gtgatcatat atgacataat catacgattc atgtttgact tcctcataaa 1958401 tatgagtcgc gatatcctta caggctttca aaaaagcgca gagcatttct gtgaaatctc 1958461 tttcttcatc gccggttgcg tttttcccga agtaatctcc tctgaaatca tgatactcac 1958521 gaaactctat atcaagagct gtgatttttt ctttatattc cttcactgcg tagtacgtaa 1958581 tgttttctcc ccgggatttc agctccttca tcacaccgat agagggatta atatgccctt 1958641 caccggggaa accgatcatt aatacattag ccatgcggca gcacccttcc tttgagaatt 1958701 tatgtaatat tttatacggt actataaatg cataaacagg taaagtattt cacttaatta 1958761 atattcatca tatataactt ttctaccagt ttatattccc tgtcttcaag acaaaaagca 1958821 ttcagcttga agcgaatgct ttaataaaga tgcgaattca gtcattttgt ctcatgatag 1958881 gattcttaat caggcccttt ttattatttt tacgttcttg gtgaaattaa cggatataat 1958941 acaccgtctt tggcaaacga catcttccct gtttcctctg aaaccacgag caccagtgca 1959001 tccgtatagc ccgacatacc aagagccgcc cggtgccggg ttcccaaatg gatatccact 1959061 tccttcgtcg tcagcgggag cacattggct gctgacacga gtttgttttc cctcactaat 1959121 aaagcgccgt catgaagagg gtttccggga aaaaagatgc tttcaattaa tgaagagctg 1959181 atctcggcgt gtagggaggt gcctttttga ataaaacgtt caaccgggtc tgctctttca 1959241 atcacaatta aagctccatg cttatgttcc gataaggctt taatcgcctt ggccagctca 1959301 ataaatgccg gcgtaaattc ctcaatgtat gattgcaaat aaaaggagga tgcaatcccc 1959361 tgcatgtcct gaaaaacgtg ccccaaatca tctaattcac aaaggagaca ctggtctttt 1959421 tcgtgaagcg ttttcaagat tagagatgca tcacctaata tttgctctaa gtacacctgt 1959481 attttcccct tgaacgcatt ttctgatatc tgctcatagc gcatagcctt catctcctgt 1959541 ttaaatttcc aacttttcac gaatgcttat cttattgatg cacattctat tggtaaagga 1959601 gggatgtaaa gaatggaaat cgaaagaatc attcagtata tttgcacctt tttaggcgtg 1959661 atttcgcttt cttttattta tgcccaaatg tttagaaaaa cgaaaccgac aaaaaaagaa 1959721 taggcccggc gttcattgct ttttatacat aaaatgttat aatttctctc gttatgaaaa 1959781 agaaacggag atcaatgtat gaaagaaact caaaacgccc gggaaaaaat caaacagctc 1959841 ttgcacattt taataccgat attcattacc caagcggggc tttctctgat cacttttcta 1959901 gatactgtga tgtcagggaa agtcagcccc gctgatttag ctggtgtcgc cattggctca 1959961 agcctttgga cccctgttta cacaggactt gcaggtatat taatggcggt caccccgatt 1960021 gtcgctcagt tattaggtgc agagaaaaaa cagaagattc cctttactgt tttacaagct 1960081 gtatacgtgg ccgcgcttct tagcatcgcc gttttagtga ttggatatgc tgcagttgac 1960141 cttattcttg gccgattgaa ccttgatatt cacgtgcatc agattgctaa acacttttta 1960201 ggctttttat cactgggaat tttcccttta tttgtttaca ccgtgttgag atcattcatc 1960261 gactcattag gaaaaacgag agtcaccatg atgattacac tcagttctct tccaatcaat 1960321 tttgtattga attatgtatt tatcttcggg aagttcggaa tgccggcact tggaggtgta 1960381 ggcgcgggac tggcatccgc gttaacttac tggtgtatat gcatcatcag ttttttcatt 1960441 attcataaaa acgcaccgtt ttctgaatac gggatttttc ttaccatgta taagttctct 1960501 tggaaagcat gcaaaaattt gctcaaaatc gggctgccta ttgggttcgc cgtgtttttt 1960561 gaaacgagca ttttcgcagc tgtcacgctt ctcatgagcc attttcatac agtgaccatc 1960621 gcgtcccacc aggcagccat gaattttgcg tctcttttat atatgctgcc gcttagcgtg 1960681 tccatggctc taacaattgt tgtcggattt gaagcgggtg cagcccgttt taaggatgca 1960741 cgctcatata gcttaatcgg catcatgatg gcgatcggct tttctttgtt cactgccgcc 1960801 tgtatccttt tattcagaga gcaaattgcg ggcatgtaca cttctgaccc cgatgtgctc 1960861 cggctgacac agcacttttt aatttatgcg ctattttttc agctttccga tgctgttgcc 1960921 gcaccgatcc agggagcact cagagggtac aaagatgtga actatacgct tgcggccgct 1960981 tttgtctctt actgggtcat tggccttccg gtcggttata tggtcggtac gtttacaagc 1961041 ctcggtgcat tcggctattg gattggatta atagcgggac tcgccgccgg agcagttggg 1961101 ctgtttttca ggctggcaaa actgcaaaaa cgttattcgc aaaaacaaca catttaaaag 1961161 aggtgatcaa tcatggcaaa aaacaaaaaa ttattcgagt atctttccca gcatgcggaa 1961221 accatcagtt caacatggta tgaaacaatc gaggagactg atcccaattc catttatgcc 1961281 tcaacagacc ctgttgtcat tcacaattta aagagccaga atcttgcctt taactataaa 1961341 ataaaccgta tttttataga tgatgaggac gtatacttgc ctatactgaa agaatgggcc 1961401 tttgaagtca cacaggatca agagcattta aaaactccta tccactatat tattcgggag 1961461 tttgtcagag tgagagattt atatgtttct tatgtgaaag aatttgtcca tctcaatcag 1961521 aatactgtga aaagcgaaga agccgaagac ctgtatcacg cccttataaa agcgtttgat 1961581 cttgtgattc atatttttat agaagaaatg tacaaaaaca caagccttca gcttcaggcc 1961641 caaaaagata tgattactga attgagcgct ccggtcatcg tgctgtttca cagcgtcgga 1961701 ctgctgcctt taatcggaga tattgataca gtccgcgcca agctgattat ggaaaacaca 1961761 ctgcatcaat gtgcgaaaaa aaaggtgaca caactgtata ttgatttgtc aggagtagct 1961821 gtgattgata cgatggttgc ccatcagctg ttcagtctga ttgaggcgct tcgtttaatc 1961881 ggtgtttctt caactttgtc tggaatccgt ccggaaatcg cgcaaacagc ggttcagcta 1961941 ggtttgtctt tcgaaggtat ttccttgaga tccactctcg cttcagctat tgcatcggac 1962001 ttaaaattaa aaaaggtata aggcttaagg ccttatacct ttttgattaa tcattccatt 1962061 gatacgtcca atatatttct tcttcaaacc atgttgccat aacaggttca ttatttttca 1962121 atttctcttc aagctctctg agcatgcctt ctgtttgtgt gcggtgagct cttaacgcat 1962181 tcattttaat atcagctact tctttgatat caagtacgac atcagcttcg ccgagaacct 1962241 cttctctgtt gcgggtaatg gccatgcaga ttgtacgcgg acggtcttct ttctttttgc 1962301 ggtataatgc acggataacc gcttccccgc atgcatcatg gtcagggtgc acaccgtgtc 1962361 cgggataaaa tgtgacaatt aaacttggtt ttacatcatc tatgatctct tccatgatat 1962421 cagctaaata ctcatcgtct tcaaattcga gcgttttgtc acggagtcca agcatccgaa 1962481 ggtcattgat atccatttct ttgcaagcgt tgatgagctc ttgttttctt agcagcggca 1962541 acgtttcccg attcgcgaaa aatggatcgc ccatatttct gcccatttca cctaaagtgg 1962601 cgcaggcata cgtaacggga atgtcttttt ttctgtttaa ggcaatgagg cctgccactc 1962661 catatgattc atcatcaggg tgaggcagga ttactagtac atgttctttc attattattc 1962721 acccttttct ttaaactgtg aacggttttt cgctgatttg cagagaaata gccagtttac 1962781 cgcccggcag gtgtcccgcc attaataaac ggttttcttc atctaccgtg tattcagtca 1962841 agccttcagc ataaatccag ccttcttctg ttttcaagcc aacgcggtaa ggcccgttgc 1962901 ctttgatttt tgcctgatga taagtgactt ttgcattgcg aatatacgca acaaccgtca 1962961 tgttcttttc atttaagtgc gctgaataag aacctgtggt ggtttctaaa tggatatata 1963021 cagggcggtc cgcatatcgt tctaaagatg cttgcacatc ttcttttatg atcgctttca 1963081 tgattgctcc cctctttctt cttttaaata ctctgcacgt tctgtatgta atttgaccag 1963141 ctgatatttc acagccggtt cgagctgtga attcacaatg cgctgaatcg cggcaaaata 1963201 tttttccagc atcggttttc ggagtcttgg atgtgttcgt ttatccaaga gctcaagatc 1963261 aatcgcctct gctaccgctt ctgcgtcatc atgtgcgaga gatcggttat tccaaagtga 1963321 agcataggct ttcactatct ctttatcatt gtccatcgtc ttgctccttt atgtcttaca 1963381 tacatgaaat gattatacat aatatatgca tcagctgaaa agccaaaggc ctcaatggct 1963441 ttttgacgcc cgtttccact tcacttgtga aaacgtaaac aagagcagcg cagcccatat 1963501 acagctgaat gtaaaagcct tcgagcttga aaatggctca tggtaaacaa acagcccgat 1963561 cagcagggta atggtcggcg caatatattg taagataccg acttgataca gtggcagccg 1963621 tttcgctcct tccgcaaaca ataagagcgg caaagccgta aacacaccgg ccaaaaagag 1963681 aagcagccac gtccctccgc tttctgcacc cgctggctga acatgtccgc tgaacagcaa 1963741 ataccccaat gcaatgggca taatcatgaa tgtttccagc gttaaaccga tggcgctcgg 1963801 caggcttgtt ctttttttgc ttaacccgta cagcccaaag ctgaatgcga gcagaagcgc 1963861 aacataagga atggagccgt attggaacgc cgagatgatg acaccggctg ccgcaatcga 1963921 aacggccact aattgcaggc gattcagttt ttcctttaaa aataaaatcc caaggagcac 1963981 tgatacaagc ggattaatgt aatagccaag actagcctca agcaaaaagc catggttgac 1964041 agcccatatg tatacaaacc agttgatcga aatcaggata gaagcaagaa ataaagagag 1964101 gatccctccg ttctttttca gagagcgcaa ctcctgccat cctattttcc attgccgcaa 1964161 gaaaaaaagt acgatacaca taaaaacaaa agaccatata atacgatgag ccaaaatatc 1964221 aagagccggc agctgttcga gaagcttcca atagagcgga aacaggcccc acatgataaa 1964281 tgaaacggct gtgtaaataa cgcctttttt tgtttctgca tgttgcattg atatccctgc 1964341 ctttctttag agcatcttat attatatcac gtgaaagatc tggtgggcat atactatttt 1964401 gtccgtgaag aaaggatgtg aagacaatgt ttgagtggaa caagtacttt cctttccaca 1964461 atcaattttc taaagaagca ttaaaaaaag ctgatccgaa agaagttgaa acgtatgtca 1964521 atcgtgtgat ggaaagtgtg ttcggcagtg attatgcggc tcaatttcct ttccgcgatc 1964581 ctctccccca aaaagaacat cccgccaaac ctgatgcaaa acctgatgtc aaacctgata 1964641 ttgatatatt cgaaacagca gaccatgtgt ttgtaaaggt gccaatcagc gaagaatggc 1964701 tggaacaagt gagaatcaaa cacacatctc acgaattatg gttggaaaac ctcccaagag 1964761 cagatcatcc gaaaaaagta aaccttcctt gtttagtcaa acgcaaagga acaaaagccg 1964821 tctataagga tggccttctg gaagtcatgt ttcaaaagca gcaagactac aatatgtccg 1964881 aggtagaaat catccgataa aaaacggcct gcaatcgatg caggccgttt tttattaata 1964941 gaagccggga tatcccccgt atggcacgcc ggcaccaaaa ccgtacggtc cgcctccata 1965001 tccataaggg ccaggaggat aggcataggg acgagaatag ttaaacagcg cactcccgag 1965061 aaaaccgcct aataaaccgc cgactagagg agcgccaaac aaaaaaggac tacgcgccgg 1965121 atatccggct ggacctggga ttccgcgtaa atacgaatga tgagggtaca tgattttttc 1965181 ctcctttatg tctgcctata cgtaaagtat tcagcaagga agaaaaacga ttgggctacg 1965241 gactgtctat gattgttaca tcacaagccc tgccaataac acacagccga gccctgtaac 1965301 cgaaagaact gttgtaagca gcgtccaggt ttgaaatgtt tctttcatgc tcaagccgaa 1965361 aaattccttt accatccaaa atcctgcatc atttacatga cacgcaatga cactgccggc 1965421 tcctgttgca agcaccatta acgcagggtt tacactgcca gcctccataa gcggagctgc 1965481 cattcccgct gtggtaagcg cagccacggt agcagagcct agacacagac gcagaaccgc 1965541 ggcgatggtc catgcaacga atagcggcga catgtttgtt tgacggaaaa aatcagcgac 1965601 ataatcgccg actccgccgt caatcagcac ctgtttaaac gctcctcccc ctcctatgat 1965661 gagcagcatc atcgcaattt gcgaaattga ttctgaaata gatctgccga tttcctgcat 1965721 agatatttta cgggcatatc ccatcgtata gagtgcaagc aacagcgaaa tgagcattgc 1965781 cgttcccgga gtgccgataa attctataat gtcttttcct tttgaatgtt cactcaataa 1965841 taaagaaaaa attgttgcca ttgccataaa gataaccggg aataaagacg tgacagcact 1965901 gatcgcaaag cccggtgttt catccagctg aaattctttc cttggtccta accccgatag 1965961 gtttccatgc ttttgatacg caccaggaaa ccgtttcatc gcaaatttat taaataaagg 1966021 cccggcaatc acagttgtcg gaacagcgat gatgattcca aaaagcagca cctggccaat 1966081 atgggcacca tatgcaactg agatagcagt tggagcagga tgcgggggca aaaatccgtg 1966141 agtaacattt aaggcggcgg ccatcgggat tcccagatac agaaaaggca tttttaattc 1966201 tttagcaatc gcgtaaacaa tcggtatcaa cagaacaaga ccgacttcaa aaaatagggc 1966261 aatcccgatg ataaaagagg caaccacaac cgccgcctgt attcgtttcc tcccgaattt 1966321 gtcaatcagc gtaatggcga tccggtagcc gcccccagca tctgagacaa gcctcccaag 1966381 catcgcgcca agtccaaaca ctaaagctaa atgccccagc tgcccgccaa ttccagtctc 1966441 aattgaaaga acaattttat tgatatccat tccaagtccg atggctacta aaaatgaaac 1966501 gacaatcagt gagacaaagg tatttaattt tactttaata atgagaaata acagaatcag 1966561 cactccgaca gctacaatta aaatcggcat ggtacccctc caaaagtgtt ttatatgatt 1966621 ctcgcgacaa tgttttggcg cttttcatgc ctagatgaac agaaagcgct ttcattaata 1966681 actaaaaacg tcttggttat atgattgtta tcttttgatc aactaatatg ttcatactaa 1966741 tctcctaatc aatgactgtc aatcgttttt atgagcttgt ctcgattacc taccgcctaa 1966801 cccaatgatt tattagttat atgttgatta acttttggtt atatgttatg ttttttaaag 1966861 ttgactgcca atcattatat ctctccattg tctggaagca aatgagacaa tatgagaaca 1966921 gacggataac aacttcataa gaggaggagt acacatgcca ttattgcgtt ttgatgtaat 1966981 tgagggccgt gatgaaaaat cgctgcaatt gttattagat actgctcacc aagcgatggt 1967041 tgaagcattt ggtgttccgg aaagagaccg ttatcaaatt gtccatcagc atcccgcaaa 1967101 cgagcttata atccaggatg cgggattagg gtttcagaga accaaggata tggtcatcat 1967161 tagcatgaca agcaaagcaa gaaccgaaag ccaaaaggaa aaattgtatg ctctgcttgc 1967221 tgaaaggcta gaaaaaaaat gcgaaatttc ccctgacgac ctcatggtat ctattactga 1967281 gaatggtgac gcagactgga gtttcggtct cggtgaggcg caatttttga atggaaaact 1967341 ataagatttc gtctccccac aaaaaaaaga agagagagct ccaaagaagc tctctctttt 1967401 ttcataaatg cggaagtcat cagtatagaa gcatccagca atacgaaaaa cctggatctc 1967461 cttttatatc cggtttaaat gccaattgga agctgactgg gttttggctg aaaatataaa 1967521 attttgctga tttgcataat aagatacatc ataatcccca tttacaatag gttggatgtt 1967581 atagcttatt gatcatttcc tattttatat atccccttca tatgcacatg acatttttgc 1967641 caatccggaa atatcagtct gacaaatata aaaagtcatg taaacgggtg tgaaccgtac 1967701 ttacatgact caccatggaa acaaaggctc tttttcaggt gccgctttcc ttatttctct 1967761 tcttcacaca ctgtgtcacc aggctcgcaa aattgatcgg cccatgcctg catttcttga 1967821 aatacagctt gaagcgctgt tcctttttca gtcagcgtgt agatgacttt gaccggcgtt 1967881 tcagggagaa cctgccgttc gacaatctcg ttttgttcaa gctccttcaa gcgctctgcc 1967941 aacatttttt ggctgatcat cggtattgtt tccgttatct ctttaaaccg tttcggccca 1968001 tccattagca catggatgat cagaccgttc catcgttttc ccagcaatga gaatgcggat 1968061 tccattttag ggcacatcgt atttcccata agtcttcatc ccttcatcta ttgattgaca 1968121 tgtattcaat gatccattac aataatcttt caagttacat ttagtaagct tctaactttt 1968181 ctattatcat accacgttta tccgaaggag gaaacactat gacgaatact ctggatgttt 1968241 taaaagcacg tgcatctgta aaggaatatg atacaaatgc cccgatctct aaggaggagc 1968301 tgactgagct attagacctt gccactaaag cgccttctgc ttggaacctt cagcattggc 1968361 attttacagt attccacagc gatgaatcaa aagcggagct tcttcctgta gcgtataatc 1968421 aaaaacaaat cgttgagtct tctgctgttg ttgccatttt aggcgattta aaggcaaatg 1968481 aaaacggtga agaagtttat gctgaattag caagccaagg ctatattacg gatgaaatca 1968541 aacaaacatt gctcggccaa atcaacggtg cttaccaaag cgagcaattc gcacgtgatt 1968601 ccgctttctt aaatgcttct ttagctgcta tgcagcttat gattgccgca aaagcaaaag 1968661 gttatgacac ttgcgcaatc ggcggattta acaaagagca gttccaaaag caatttgata 1968721 tcagtgagcg ctatgttccg gttatgctta tttcaatcgg caaagcagtg aagcctgcgc 1968781 atcaaagcaa ccgtctgccg ctttcaaaag tatcaacttg gctgtaagga tatgaaaaac 1968841 cttagtccga aatccggact aaggtttttt tatacaatcg cctctttgta ccattcacga 1968901 gcctgttcag cttcatgctg agtcagctga tggcccccgt cctgccagta aacggaggct 1968961 gatgccccgc tgtcacgcaa atagcggtaa agctcttctg attcttcctt cgtgcaaaga 1969021 ggatcgtatt tcccggcacc gataaaaaca gggagccccg ccatatcagg cagctcgata 1969081 ccccgaatcg gaaccattgg atgatgcaga atagcccctt ttaacacatc tttataatga 1969141 aaaagcaggc ttgccgcaat gtttgcgccg tttgaataac cgactgcaat cactcggccg 1969201 cgattaaact gatgcgtttc tgcagcctcg tcgataaaat ctttcaattc tcttgtccgc 1969261 accacaagat ccttttcatc aaaaactcct tcactcagac gtttgaaaaa tcgcggcatt 1969321 ccattttcaa gcaccgatcc tctgacacca agcaaatggg catcagggtc tataaaccgc 1969381 cccaatgaaa gcagatcgtg ttcattacca cccgtgccat gcaacagcaa aagtacgttg 1969441 tcagatgttc ctttctcata aatatgcttc attataaatt ccccctttta aagttcaggt 1969501 aaaatgtctg taatttgttg tctatgtttc tccagccatt caggcagttt taaggaagtc 1969561 cctagctcag caaacgtttc atctgtcata aagcccggtt catctgtggc aatttcaaat 1969621 aagataccgc ctttctccct aaaataaact gatgtaaagt attccctgtc gagaatttct 1969681 gacgaaggca gatggttttc agcaataatc ggcagccatt tcgcctgttc ctttttctta 1969741 gtccgaaacg ctacatggtg taccgtacca tatcctccga ctcctctttt ttcaggatgt 1969801 aaatggacat caatgacacc gccgaccgcc gctgaagatg ccagtctgac aatctggtct 1969861 tcttcggcca ctttggtgta tccaaagctt tccgttaaca attgtatggt cgcctgcggg 1969921 tcgtaggaat atagcagcac acctttcatt cccgtaattg cttcatttgt tgtgatcccg 1969981 tcaggcgtcc actcgctttt gccgcttttc gcatcctcca tgatcgccag cggaaggtct 1970041 tctgtatcat caaaaataag acctttttca ccaaacaacg ttttttcctc taggctcagc 1970101 ccgcttttct caagacgttc cttccaaaaa gacagggagc ctgagggaac tgaaaagtac 1970161 acccggcccg cttggccttt tcctaccgtt ccctgtccgc ttccttggaa cggaaaaaag 1970221 gtcattattg taccgggatc tccgttttga ttcccaaagt aaaaatgata cgttccggga 1970281 tcatcaaagt ttactgtttt tttaacgagc ctgagcccaa gcacttctgt ataaaatcgc 1970341 aagttttctt gcggatctct ggcgaatgct gtgacatggt gcaatccttc tgttttcatt 1970401 ttctcactcc tatttatctc gatttcaaga tatttattat tttaaacctt tattgaaaag 1970461 gatgcaaacc atgtgttttg attaaataat tgaaaaaatc atttttttct aataattatc 1970521 ttgtgatctt ttcttacaac tgctattata gtgagcatta tcatgtttca ggaggaaagt 1970581 aaatggttaa aaaagcactt attgttattc tcattctttt gccattcgtt cagctcgcgc 1970641 ttttgccgct tgtgaatcga atagaaccga ttatgttcgg cctgccgttt ttccactttt 1970701 ggctgctgct gtggattatt gttacgccgt tatgctcgtt tggcatttat cagatgcaaa 1970761 aaaaagatgg aggacttgaa taatgcaagg gaatctgact gcacttctca ttactgctat 1970821 tattgtttta accgttgtct gtatcggctt tctcgccgga agagacaaat cctcacgtac 1970881 ttctgtggaa gaatggtctg tcggcggcag acgcttcggc ggtcttctcg tctggttttt 1970941 agtaggcgct gacctttata cggcctatac tttcttaggg ttgaccagta ctgcttttac 1971001 aggcggaagt gttgcatttt tcgccattcc ttattctgtg ttggcctact ttatcgccta 1971061 cttcttcttg ccaaaacttt ggaaagttgc gaaaattcat aaattaacaa cactcgcgga 1971121 ttatgcccgg gaacgtttta acagtaagct tttggcaagc ctcgttgcca tcgttggggt 1971181 actcatgctt attccgtaca tatgccttca gctgagcggc attcaagaca cgcttcaggt 1971241 tgccggcact ggctatatta acgtaaaatt cgttgtgatc atttcattta ttcttgttgc 1971301 tctttacaca ttcttcagcg ggattaaagg gcccacatat acagccatca ttaaggacat 1971361 tttagtatgg gtcattatgc tgtttatggt ggtgtccctc cctctcattc attttaacgg 1971421 ctggacgcca atgattgaca cgttagtgaa ggaagcgccg caaatgctga cgataccgtc 1971481 agaagggcca aaaggcattc cttggtttat cacagcatct attgtttccg ctctggcact 1971541 ttttatgtgg gcacatgccg ctacaggtgt tttcacggcg aaaagcgctg atgcagtaag 1971601 aaaaaacagc atgtttttgc cgctttataa tatcgtgtta attttggtta tttttcttgg 1971661 ctttatcgcc tttcttgttc tgccggaaga tacaaatcca aggctggcgc tgctgcattt 1971721 gattcaaaca tcttacggcg gcgtggcaca aggctttgca tatgccacta tcgctcttgc 1971781 ttcattaata ccttgttcca ttatggcaat cggcgcatcg aatttattcg ccaacaacct 1971841 ataccgggat ttgattcatc cgaatgtgtc gcaaagcaag ctgactcttg tcacacgttc 1971901 aatggtgttt gttgtcatcg gtcttgcgct gctgtttgga atgctgttcc cgactgcctt 1971961 agtgacactt cagctattag gtgtatccgg tatggtgcaa atcttccctg cgattgctgt 1972021 cagcctgttc tggaaaaacc aaacgaaaga agcaacggtt atcggattat tagccggcct 1972081 agcggtaacg tttattgtgt atatcactca atccgcacat ggcatttatg aaggattctg 1972141 gggattggcc gccaacatga tcgctgtggt catcctgaat ccgctgttcg ttaaaaacgc 1972201 gggatccaat cctgtcattg aaggtttatt tggcaaaaaa caagacgcta atccaaatca 1972261 aaagggcgca taaaaaaacc atacgcggca gccgcgtatg gtttttttta catttctttt 1972321 ttcagtgttt caattgcctt ttccatttgc gtatcattat cagacagctt cttttgaagt 1972381 tctatcatta atttcgttgt tgtatcgcca gtcagtatgc ctgtttcatt cagcttctct 1972441 tttttctgga actgtttgac gacagataca aaatcctggt catacatact gttaaccttt 1972501 accttgtaac caagtgcttt gagcattttc tgagccactt tgacgtttgt gcctgtatca 1972561 cctgatttgt acgttttatc tgcgtccaaa tacggcagct tcgcgtaatc aggcagctct 1972621 gctttcactt gaggcttgat gccttttttg tgaatccatt cgccatcagc agtcagccat 1972681 ttggcaactg tcagtttgac ggtagagcca tcatcatatt cttttgccgt ttgtactgta 1972741 cctttgccga atgtcgtctc gccgattaac ggtacgtttg acgattcatg aagggcagcg 1972801 gccataattt cggctgcgct tgctgtaccg tcatttacta aaacgacggt cggcttggtc 1972861 actttccgtt ctttttcggc cttcatgact tcttttgaac cgtttttgta ttcaacctgc 1972921 atgatgtttt tccctttatc aatgaacagg ttgctcatcg taatcgcctg ttccattaag 1972981 ccgcccgggt tgcctctcaa gtctaaaata tagcctttgg cgcctttttt ctctaaactg 1973041 tcaatcgcat ctgtcagctc tttagctgtt gtttcagaga aagaagtgat ttgaatttct 1973101 ccgatgttgt tgtctttcat ctctgaatag acagtctcta caggaatggt atcgcgctta 1973161 atggaaagat cgatattccc cactcccgct ctgttcagtt caagcttcac ctttgtgccc 1973221 tttttgcctc ggattaaagc gacggcttca tttacattca tgccttttac gctttttcca 1973281 tttaccttaa tgatttggtc cctcggtttg ataccggctt tttcagcagg tgaaccttta 1973341 attggggata caataaggat ttctccgtct ttctcctcta cttgggctcc gattccttca 1973401 aaagatgctg aaatcgtctc gtcgaatgat ttcgcttgct cttgatccat atatgtagaa 1973461 tacggatcat ccagtgattg aatcattcct ttaattgctc cgtctactaa tttgtcatca 1973521 tctgtttttt ggtaataatc acttttgatt tgctcatacg ctttatttaa tttgtcgaac 1973581 ttgctgtctc ctgtgcttgc tgatttttgg cccaggatac tggaattgcc cgtaataaat 1973641 aaagtaagcg ccgaagcgac aactgcagtg atcagcacaa taaaaaacag ttttaattgc 1973701 cgtttcaatt aaacaccacc tttttcttct tacattatta tcatggacga attcttattc 1973761 gtcaactcgg agcagaaatg aaagagaaac gcccttcttt tgcttttcat aaacctatgt 1973821 ctttatacga catatgataa ggaaaaagga ggattcgata ttgagccgat atttagaaat 1973881 gctgtcctta ttcggtgtcg caggggcgca cccaggcggg ctggcttttt caaaagcggt 1973941 cttgcaaaag gctgcaccct ctccggatca gccgattctt gatgccggat gcggaacagg 1974001 gcaaacggcg gcttatttag gacatttgct gtatcctgta acagtcgttg ataaagatcc 1974061 tattatgctt gagaaagcga aaaaaagatt tgcgaatgaa gggcttgcca tccctgcata 1974121 tcaggcggag ctggaacatc tcccgttttc ttctgagtcc ttttcctgcg tcctgtcaga 1974181 atcggtcctc agtttttcac gcctgacatc ctctcttcaa gaaatttcaa gagttttaaa 1974241 acccagcggg atgctgattg gtatcgaagc tgctttaaaa aaaccaatgc cccctgcaga 1974301 aaagaagcaa atgatggatt tttacggatt tacttgctta catgaagaaa gcgaatggca 1974361 taaactccta agatcctatg gctttcaaaa aacagaagcg atgtcacttc ttccggaaga 1974421 catggaattt gaaccaacca cagaaatgga tttatcgcaa acgattgatc ccatctatta 1974481 cgatacgctt caaacacatt atcagctcat gcagttatat agtgagtaca tgggtcattg 1974541 tatttttatc gcgtacaagt aaaacggcgt atcgccccct gttttcgtcc aacctttttt 1974601 tcctatctat catatgctga tagaaagtca ggataggagg ggaacaatat tggagagata 1974661 ttatcatctt tgcaaaaacc atcaaggtaa agtcgtcaga attacagaga gaggcgggag 1974721 agttcacgtc ggcagaatta cccgtgtaac aagagacaga gtttttatag ctccggtcgg 1974781 cggagggcca agaggtttcg gttacggata ttggggcggt tattggggat atggagcggc 1974841 ttacgggatt tccctcggtt taattgcagg agtggctctg gctggtttat tcttctggta 1974901 agcatagaac aaatgctaga ttcaccagac acaatgaagc ccgcttatct agtgtaagcg 1974961 ggcttttcat tttaaatttt cttcactttt tcaaagtact cttcaagcgt taaatcatta 1975021 tcttggatga cctttgcggc ttttttgcct acatagcgca gatgccatgg ctcatattca 1975081 tatttcgtga tatcttcttt atttttcgga tagcgaataa taaagccata tttataagca 1975141 ttgtcctgca cccatttccc gtctgccgtg cttccgaacg cttcatttag ctcaaagcca 1975201 ttgctccggc tcgaaatgtc catcgcaagg cctgtttgat gctcgctttc acccgggtaa 1975261 gcgaccgctt cctttgcctt cctttcccct tttaggctta cttcattgtc aaaaatgact 1975321 ttctgtctgt catacgaacg gtaccctgag acagctgcca gttcatagcc ttcctttttg 1975381 gcagcatcga acattgtttt taatgcgtcg gccgcttctt ttctgatgta acgtttttga 1975441 atcttttctt caaaagaaaa ctctacatca ggtatgacaa gatcgctagg ttcatagttt 1975501 ccgggcagtg catattgttt attgacaagc gcgagtatat tttctggatt ttgaatggtt 1975561 tccagaccat cgactttttt aatatcattg aaatactggc tttccaatga aaactcactg 1975621 ttttgagtgt ttgatttttt gctgtcagct gttttttgtt ctgtttgctt tgtttctgct 1975681 gtggttttcg tatccttttg agcatctccg ttcgacatgc tgcagccggc tccgactatt 1975741 gccgttacac tcagagcggc agccagtgag aaccatttac cggacttttt catattacat 1975801 taccttcctt ttatcaatcg tttccgcatg cataaagaag aggctgccgg cacccagcac 1975861 gcctcttgat atattttatt gtgatacgga atgtaaagcc acttctatca tatcatgaaa 1975921 tgtcgtttga cgctcttccg ctgtcgtttc ttctcctgtt aatacgtgat cactcacggt 1975981 gagaattgac agggcttttc ttccgtgctt cgctgctaat gtatacaatg cagttgtttc 1976041 catttcaacg ccaagcacac cgtattttgc aagtttttca atttgcgaat cgtcattgta 1976101 gaactggtca gctgtaaata cgcttcctac agtcaccggc acacctttat cctttgcggc 1976161 atcataggca ttttttaaaa gctcgaaatc tgcgcaaggc gcaaaatcaa cgcttccgaa 1976221 agcaactctg ttcatttgtg aatcagttga ggaggtcatc gccaaaatga cgtctcgcac 1976281 tttgacatct ttacgaatag cgccgcagga accgactctt attagatttt gcacatcgta 1976341 gctttgaatt aattcattca cataaattga aatagacgga actcccattc ccgtgccttg 1976401 tactgagatt tttttacctt tatatgtacc cgtaaatcca tacatgcctc tgacttcatt 1976461 gtagcattct acattttcaa gatacgtttc tgcaataaat tttgctctga gaggatctcc 1976521 cggcaaaagc acagtatccg caatttgtcc tttttcagca cctatatgta cactcatctc 1976581 atatcctcct gtaaatctaa attatcatcc agcccgtcca ttttacaacg aatgtcatga 1976641 tgaaacaaac ttcagcattg attataaagg aatatatcga aaaaagaaat gttcgaggat 1976701 ctgttaggca cttcctcaga aaaacggata atcggggtgt taatttgaaa acctaaccgc 1976761 aggaaggagg ggtgggacat gggtaaaaaa catcgtaacc ggatcaccgg ccaaaaaaag 1976821 aacaatcata tacctgaaaa agatatcatt gcagctgaag aagcacacgg gaaagaatat 1976881 tccgctgcca aacgcaagcc ttaaaactgc agaaaactgc gggtttccgc agttttcttt 1976941 tcattatgtc gtttgtacaa tcagacgatt gattttcctc cagccggcgg gaagcagttg 1977001 ataatatgtt ttcccttttc tgccttcatc aatcaggatc acgtcccctg tggccatgaa 1977061 tcttgcatca taatcactcg gaacagtgtc gaatacatta aacaaagaga atgctctttt 1977121 cagcacgtct tgatgatcgc tcccgttcag ttcagttcga tagacggctc tgtagccctt 1977181 tttttcgcca aaccggggtg tctgaaatat tgtcacgtca taggaacaag acttcttttt 1977241 aaacacggat aacatcatca agatcccctc ccttttattt ctttaacata ttggcgtttt 1977301 tgctgtgttt tcctctctct atttttgtcg aaaccgctta atcttttcgt caaaaccttt 1977361 tactaggaaa aacagaagca agccgaggct aaagcctcct aacacgtctg tcacaaaatg 1977421 aacccccaga tacactctgc ttatgccgac taaaacagca attacaccgg ctatgatata 1977481 taccattttt ttatgcttag acaaaaacgg gagatgtttc actaaaaagt aagcaataac 1977541 aggatagaca caagcagcat tcatggaatg gccgctcgga aaactgaagg atgattcatg 1977601 aaccagcggt gcaaaatcag gcctcactct ttcgatccat tcttttaaga ctttgtttaa 1977661 cagccgatct gtgccgaata ctaagagcat caacaggccg tcccatgttt ttctgtagaa 1977721 aaacatgcct gctccaatga tgacaattag agggagcaga aaagaagaag caccaagatg 1977781 cgtgatcccc gtcatgactt cattaagcca tggctgacgg atcaaaacag ctgccttgct 1977841 tattgcttca tctgcagatt gaacagcatt tgtatgaatg gccgcagcta gaattaaaaa 1977901 gaaaagaaac aaactaacgg gcttgtacaa ttttaaccac ctcaattttc acagaagtca 1977961 tagaacatga ataataaaac cggagctgac cgctccggtt ttaagcctca ctcatcttca 1978021 tccagctctt catctatcat acatttttct atcaaataat caaaggtaat atcagcgatt 1978081 tcaaacagct catcctcact cggtatgtag ccccgtcttg caagctctct gtaaaaaaat 1978141 tcagcgattt cttccgtatc aatcacaaga tctatttctt tcatctccgt accgcctcct 1978201 tttttatgtt ttatgaaaaa acaggctgaa ttatacccgg tgttctaaac aattctttca 1978261 gtcatatatt gaataaaaaa cgagccatgg gaggctgacg ctatgattgc taaaatgatg 1978321 gaagcactgg acggagaaag atttgatatc ataatggaaa aaacgctcaa aggaatgacg 1978381 cgtgtgatga tttggggctg tctgccatat tttttatatg tcttgatccg tatgttcaca 1978441 aattaactga aatgctcttt taaactttcc aaaacaaaca tcatcatgtc tttatattct 1978501 tcatcctgaa acatttcgta cagaattttg tagtcattat aaatatccag aagctcatca 1978561 acaattgaca cagcaaggat gtgaagggta tcttgatctt catcaccgcc ttcaaactga 1978621 agaagagcag acgatgcgat atcttcgccg atctcatggc cagtttctcc gacataatgg 1978681 acaaacaaca gctgatgcac aaactggtcc atttcatatt ttctaagcac cagcgtgaga 1978741 tcctcttcct ccgtttcaag ccactctcca tcctttaaac gggtcagctc ataaatgata 1978801 tcttcccagc catcttctaa atatctccaa atttctgttc tatggccgat aatgcgaaag 1978861 agttcttttc cataatcttt aacataaaca acgtccccaa taaggaattc atactcaata 1978921 tcaagcttct ccatgtcgac aatgacaccc tcataatctt tataaagctg aatagatgat 1978981 tcaaagtata aaacttcgtt atgattgact tcataaagat agtgtttatc aatttggtgt 1979041 acttttgtga tggtgccgac tgttccatac ataatgacga ctacgatatc ccctacttgg 1979101 aatttcggtt tattttgctt catggtgtct ccccctcgcc gcaacatttc tcatacgcta 1979161 tcgtatgccg ggtgaagcca attcgcatgg gcatgaaaac caaaggaaat atccaattat 1979221 ggtatgggta tggacataaa aaaatccgca gtgatctgcg gatgaaacag ctattatctg 1979281 ccgtgcactt cagactcgta ttgatcccaa gcttcatcaa acgtcgccat cgtgtgaagg 1979341 taatcagcat tcagctccaa atatgaactg atttcatgat aatcggttga tgtttttgga 1979401 aagctgtgat cctcatacgc ctgattggca aattcactga tgctgtcctt cggcttaggg 1979461 tgtctgtatt tcaataaata gtgataaaag gatttcatgg gtttcccctc ctgatgtctg 1979521 tcttttgttg ttctattata cagttcaagt gtaaaattac aacaaaagaa tactgaaaca 1979581 tgactcagga gaagtcaaaa tagttgcgtt tcaaaattct ttctgtctcc atgagctgct 1979641 gatatgtcag gctttcaggc agtttttttg tttgaattaa aagcagctga tcctcaatct 1979701 ctttaaccgt gttttcctct tgataggtca taccgcagga agaacatacc atggcagggg 1979761 tgtctgtcag ttctatagcc ctcgttccat cagggagctc ccagtacacc gtgttcctgc 1979821 cgggcaccgc ttcgagctcg ccgcaccatt cgcatgtttt catgaagaat cccctccgca 1979881 ttcagtctct ttctgttttt tctgctgcgc caaaaatttc ttttctttga gctgatctct 1979941 tttctcacgc cgatctttta atgtttcatg ctccggattt gcgatgtatg cctctctcct 1980001 tttgattctg tctacatttt caggtgtaaa cgaaacttct ttgtcagcaa aaatggcact 1980061 cagcccgatc ggctcctttt tgtcagcggt ttcagggaaa acggactcaa aataggcgtc 1980121 tgcctgattg gggatataat tctctggttc cggatatgac gtaatcacac cttcaaaatt 1980181 tcttaagatc actttgtcag gactttgtga caggacatag tttggctgca gggcgatttt 1980241 acctcctccg cctggtgcgt caacgacaaa ggtaggaacc gcatagcctg aggtatgacc 1980301 tctcagccct tcaatgatct ccaaaccttt ggaaacagga gctctgaaat gccctattcc 1980361 ttctgacaga tcacattggt aaatataata aggacggact ctgattttta ccaagtcatg 1980421 catgagcttt ttcataattg gaaccgaatc attaatacct gctaatacga cagcctgatt 1980481 tccgaccggc actcccgcgt tcaccagctt ttcacatgcc tcaacggatt cttctgtcat 1980541 ttcgatgctt gtgttaaaat gggtgttcag ccagaccgga tgatattttt tcaatatctc 1980601 gcacagatga tcggtaatgc gctgcggaaa gacgacggga gctcttgttc cgattctgat 1980661 gacttccaga tgcggaatgc tgcgcagctc ttttaaaata tattctaaaa tttggtcgtt 1980721 gatgagcagc ccatcaccgc ctgaaattaa acaatcgcgg atttcgggtg tttcccggat 1980781 ataagcaatt gcagcatcaa gctgtttttt ggggacgccc attccgattt gtccggaaaa 1980841 gcgccttctt gtgcagtagc ggcagtacat ggaacattga ttcgtgacaa gaaacagcac 1980901 acggtcggga tagcggtgtg tcagaccggg taccggtgaa tcttcatcct catgaagcgg 1980961 gtcttccaga tcgtattttg ttttgtgcat ttcttcagaa agcggcacag actgcatgcg 1981021 taccgggcat ctcggattgt cggggtccat taaagaagca tagtaaggtg taatatttaa 1981081 ggggatcgtt ttggtagaaa ttctgacgcc ttcctcttca tcctcggtca gattaatgac 1981141 tttctttaaa tcatctaacg ttcttacagt gtgtgtcagc tgccaaagcc aatcgttcca 1981201 tttctcttcc ggaacgtcct tccataactc gatctccttc caatgccgtt tcggtttata 1981261 ccatttgttt ttcaaacgaa ctcctcctcg cgcatatttt gacttacagt tgcttgcacc 1981321 aaatattcat gttttcaagg ccttcggcta taaagcaatt attgatcagc cttccgccat 1981381 actgataacc tgaatggtac aacacagcat tcatcccaaa agacgaagca cgggcgagag 1981441 aaaacacatg aacgatatcc tctccagcca tttctttttc taacgcctcg attaaaaagc 1981501 ttgttaacga atggccgcga tattccggca gcacagcgca atcggttatt tctgcatgcc 1981561 caagctctgg attgatttct gcgcttgctg cgctgatcag gcggtcatga tcaagcatga 1981621 tataatacac cgtatttgca ttcatcgtct tttcaatata agcggggtca aataccgggg 1981681 ttgggtacgt gcggaatact tttttataca gcatcgatag ctggtacatg tcgtttgttt 1981741 ctgcttttct catcgtaaaa acgggtgtac tgtcgttgcg aagacggggc gctgtgcgat 1981801 atatggcttc gatgatctcc tgttcctctg tataagaatc tgtttgtctc cggctttctg 1981861 aaaggtaacg taccatgaca caagccgaat ggccgagata atagcccttt agatagccct 1981921 ccggcgcaaa taattgtttg gcaaggatcg gctcatcatg ctgcttcgca tagacaatga 1981981 ttttttctgc attctcttct tttgccgctg ccacgatatc cggcagggcc ttctcaatgg 1982041 ctccgtcata acgaaccact ctgattcgtt tattaaagcc gtcatggtcc aaaactgctg 1982101 tgacaccgct actctttatt gacttgagca tccgcatcct ccccatctgt atgaaggccg 1982161 caccaatcca tgacaaaaag tgcaataatt ttagcagatt ctatcatggc ttcaacctca 1982221 atgtattcat tggcctgatg agccgttttt gtttcccccg gcccgaaaac gatcactggt 1982281 gtatctcctg catggtacaa aagccctcca tccgttcccc acggggaagc ctcaataatc 1982341 ggctctgtct gtttcatttt ttgataggct gattgcagca cagaaattaa agggtgatca 1982401 tcaggtaaat cattcggcag ccattgagcg ccaaaccatt cgacttgtac gggatggcgt 1982461 ttaaaccatt cgtcatggta ttctaaatcc ttcagccagt tttccaattc aagttttaca 1982521 gcttctggtt tctcatgggg agcaattccg catctccctt ctatgacgac acggtctgca 1982581 actgaagatg gccaggcacc gcctgagatg gtgccgatat tcaccggtac cggtattggg 1982641 atattgtcat acagcggatc tgaaattctc gcattgcgga ctttctccag ctcttgtatc 1982701 gctgtgataa cgtgcatgct tttttcaatc gcgcttaccc cttcatagcg tgtgccccca 1982761 tgtgcggata atcccttcac agtgatccga aaccacatcg aaccctgctg cttaataaat 1982821 agtttcatat tcgtcggttc aggaatcagc gccccgtcag cacgatagcc tctcatgatg 1982881 gcggaaagtg taccggcgcc gccgcactct tcatctacaa cactctgaaa caatacatct 1982941 cccttcagtt tgacatcgca ggcgtgcagg gcttctaaag caaaaagaag ggctgtattg 1983001 cctcccttca tatccgttga gccgcggccg tatattttac cgttttcttc gacagcttga 1983061 tacggttcat acttccaatc ctttacgctt ccttcaggca caacatcgat atggccgttc 1983121 aaaatcaggg acctgcctcc gccggctccc gtttttttag ccacgatatt cgggctctca 1983181 tgaaaatcgg atcggttaga tttaaagtag ggatgctgtt ttaattgctt tatgcttggc 1983241 tcccatacat caatgtccat atgaaattgc cgcagctttt caagcacaac agcttgggcg 1983301 ttaaactctg accccaatgt gcttttttcc ccaatcagcc ttttgagaag acgaatggct 1983361 ttggccgaat gctgatcaag ccactcgatt acttttcttt caatgtcttg catcctcatt 1983421 ccccctctta agaaaaaggc atatctattt tgatttcagc ttctgtcagc ctcgtcacct 1983481 catcgattgt cgagccattc atcagctctt ttaaaatgaa gtgatggcta tcgacctcaa 1983541 gaaccgcttt ttcggtaata atcaaatcta cacagcctgc agcagttaat ggcagcgtac 1983601 atctttctgt taatttaggc cttccctttt gatctgtatg actcatgacg acaaccactt 1983661 ttttcgcttt ttgggcaagc tccatcgccc cgcccatacc aggcaccttt tttcccggaa 1983721 caagccaatt tgccaaatct cctgattggc tcacctgcag ggcgcctaaa atcgtaatgt 1983781 caattttgcc ttttctgatc atcgcaaaag acatggttgt atcaaaataa gaagcccctt 1983841 ttacagcgcg gacaggatat cccgcggcgt tgcataaatg cgcatcctct tctccctttt 1983901 cgggactttc tccaatgcca aggacaccgt tttccgcttg aaacatgacc tgcatgtcag 1983961 gcttcaaaaa gttcggtacc aaggaaggga taccgatacc gagattcaca atcatgccct 1984021 gcttaatttc agtagcagcg cgttttgcaa tctgttctct ttctgctact cccaagccca 1984081 tttccacttc actccctcgc ttcgtacaac cccctcaaca aaaacccccg gtgtgacaat 1984141 catttcttca gaaatctccc ccatcggaac gatacgctca gcttcggcaa aggttctcct 1984201 ggcggccatt gccataagcg ggttcatatt gcgcgcggtt ttgtcatacg ttagattgcc 1984261 gaattcatct gcaatgtaag cattgatgaa agcaaaatca gcagtcagcg cctcttcaat 1984321 caagtatcgt tttcccgcca ctgttacgat gtcctttttt tcgcaaacca tttgattatc 1984381 aatgcccacg tcggttaaaa taccgccaag ccccgctccg ccggcgcgaa tccgttccgc 1984441 aagcgttccc tgaggtgaaa attgaacctc taacgtcccc tctgtcatct gttttccggc 1984501 tactggattg gaaccgatat gcgaggcgat cagggttttg acccgttgat taacaataag 1984561 cgggccgatt ccgatatccg ggaaaccggc gtcattgcaa atcacagtca aatccgttac 1984621 accgctgtcc aatatcgctt caatcaatga aggaggcgac ccgactcccc caaaaccgcc 1984681 aaacatcaga accgatccat cccgaacatc tgcaattgct gtgtcaatgc tgattgcttt 1984741 ttgaaatggc gccatttaat gtcaatcctt ttttaagttt ttttcgaccg ctgcaactgt 1984801 ttctgaaaaa atagagataa gctcttccat ttcaccgtct gaaatagtaa aaggaggagc 1984861 aataatgaca gcatctcctt ctccactgtc tattccagct ttggaaggat aaacaatcag 1984921 cccgcgtttt ttcgcctcgc tgacaataag ctgggttatc gcctgctctg gcggaaacac 1984981 tttcttcgtt ttttggtctg ccacaaattc aatgcctaat agcagtcctt ttccgcgcac 1985041 ctcacctata atgccgcttt gagatgccgc ctcatcaagc ttcttcttca gcacagcgcc 1985101 ctttttttct gattgtttga tcaagccgtg ctttaacaca tatcgcaaaa cttcaagagc 1985161 agctttggct gaatagggat gtgcactata tgtgtgaccg ctcataatca cacctgaccc 1985221 ttgttttatg gtttcaataa tagaatcaga tacgacggca gcagcaatag gtgcataccc 1985281 cgcaccgagt cccttcccca gtacagcaat atcaggtacg gtatcccaat gctctgtcgc 1985341 gagcatcctt cctgttctcc caagccccgt catcacttca tctgcaataa aaagcacatc 1985401 gtgtgtgcgg catacctcac ttaatctctc ataatatccc ggaggcggag taatcgctgc 1985461 tcctgcagca ccaataatag gctcagccac aaagccggcg atgaattggc ttccgattct 1985521 tttaatcatg gtgtccagtt catcagctgc agtctgaaca aagtcttctt ccgtctcgtg 1985581 attcagccga taaatatgtg gagctgagat agctggatac cgctcaatga gatgggtgaa 1985641 ccggtatctc ctttcataaa aaccagacaa tgaaagcgct cccaaagtta ttccgtggta 1985701 actgctccat cgagacaaaa agatggattt ttgtgtttgc tttttttcct gccaatactg 1985761 aatggcgatt ttcatagctg tttctatcgc ttctgatccg ctgttgacaa aaaaagacca 1985821 attcacatct ccgggcagct cctgtgccaa gagagcggct aattgctcgg cgggctcact 1985881 cgtaaactgt gagcggtaag caaaagacac ctgatcaagc tgttctttca gcttctcagt 1985941 cacatcacga actccgtggc cgatattaca tgtcaccgca cctgacgagc cgtcgagata 1986001 tttttttccg gtctgatcat aaacatatga acccttcgca taactgacaa ccggataggc 1986061 cgagctaagc tctggcttaa tcaaataact gctcatgctc ccacctcaaa acccctttta 1986121 ccatattgta tgagtgtcca aatggcggca tgacgttccc cgcaaaaact ttttcacata 1986181 aaaagagcct tcctaataag gaaggctctt ttgaaatttc agcatctagc aaataaaagc 1986241 ggctccaaca ataattaata aaatgaacaa gacaacaatt aacacaaatg tatttgtccc 1986301 gcagccaaat ccgtaaccgt acccagagta tccatacatg ctgttttcat cctttcttat 1986361 cacgatatac gacattttat gcgggccaag tcccaaatgg tttgtgcaaa cgcctatttc 1986421 atgtaaggaa ataatgaaat acagtatgca cccgctcata ttttttaaac gtcagctttt 1986481 cgtaaaactg agttgcaccg tcagtgcttg cagccactaa gtaggctgct tccattccta 1986541 gtgatttggc gatggacagc atttctttca ctaagatact gccgtagccc ttcctttgaa 1986601 actgatctaa aattgccact tcttcgattt tagccgtttt ctcttgatga tcgataaaca 1986661 gctcgccgca cccaatggga actttctgtg cctggtcgct gtaacaaaca acaagaatga 1986721 ttatatctgc ttcatagaaa ggatattttc tttttaattt ttgttcagcg attgcttctc 1986781 caatataaat ggaatcgtaa attttcataa tagaagatcc gtcgctaaga ctttttgccg 1986841 tcccccatgc ggttaaagga tgtcccatct gccccttcca gtcactaagc ttcatgtcat 1986901 atagtagctc atcctcgacg acaaaaccgc tttttacaag tgactgcttc aaaccgagcg 1986961 gaaaaacatg ctgcggcgac gcttttaaat ggagataatt cgcatcaagc agctttggta 1987021 cggagggtaa aaagttaagt aaccgctcca atggaaacgt atcatggagc tgaacaaagt 1987081 tatgagaaaa aatttgcgga agctgcggat ctctgtatac gctgtaatga tcaaacgatg 1987141 ccgattcaga cgttaacaat atatattgat gttccgtttt tgaataatgt cctgtcatga 1987201 acgtctcctt tttatgacct atacctttac tctgttgcaa tattcaattt ctttataatc 1987261 tcatcgtaca ccggataaaa cggctttcca attggaaatt gctgaatatt tcggaaagaa 1987321 gcggagattg gcttctgatg taaaaaaaac ttccttgtta cttgttcact aatcgggtga 1987381 aagacgccgt ttagaaacaa aaacggctcg cgttcgatga aaaacagacg tcggccaggc 1987441 ggatttttga tcaattcaga tcgtttccac gtaatcggcg gcccttccgg aagcgtctcc 1987501 atctcttctt ttccaattgt cactatgtct tttctttgaa attgataaaa ttgaaacgca 1987561 tactggtcca caattcgcct tttttttccg gcttcgatat aaaatattgc aggatggtca 1987621 gcttccttta ctaaaatata attcggaatg tttaaaattt tgccaatcct atattggaat 1987681 aaatatgggt ctggaacagc gacagtccga tttagataca aaaaacccca cttttctcca 1987741 acaggatgcc ttacaccctg atcaaaaaaa tacacatttt gatctgaacc ttttacaaaa 1987801 gagccgtcaa tcaaatcggc gggcagaaac cgatatgcat tttgaaatga atctggggtt 1987861 ttataggttg tgtctaatac ttcatttatc ggcagaaatg gggtaaagtt gttgagtctc 1987921 gcccaaaaaa ttgcgtcgcc atgattccaa tgcttcatat catcatccca gtagcctcca 1987981 aatttatggt gaatgagatt aagtaacgaa cggcgatgca taactgagca atgatcaact 1988041 tgaaaagcgg cctgatcaag cactgcattg gcatttctgt agaaatgtga gatttcctct 1988101 cccctttcgt ttacatgtac aactttttgt tttgaataga ccgcctgcgc ttcaggctta 1988161 tgtgaaaact cttgcaccat acggctcagc cgctcaggat gataaacagt gtcgtcagta 1988221 agataggaaa tgtaatcgcc gtctgcaaat gggagcgcac tgttaattaa tgtggcataa 1988281 cgggctgttt ttaatcgatc tgcaggatgc acgaaactgt tatgatattg aatgcgccgg 1988341 tcatggagat acttgtgaat caccgcagtt gtttctgcat tcgaatgatc atccatgata 1988401 aaaagctccc aaagatcatg cgtttgctgt atcacgcttt cgatcgcttt ttgcaaataa 1988461 tcgggtttgt tgtaacttgt taaaataata gacactttct ctcccatcta taccgcctcc 1988521 cgccgtcaaa cataaaaacg gctccgcagc aagcagagcc tctgtcatca tttaaaaagc 1988581 accccagctt acaacacttg agagtgaaac atgagatctc gtgttattta acgggttttg 1988641 gaaaataacc aaatcagtca gaacttcttt tacgatgaca ttttgaagtg tatctccgtt 1988701 gatcaaattg acttttgaaa ccggtacgcc cagctctttt gcaaaaacaa gctggcgtct 1988761 gaggtcagat ggatttcctt cagaagacga ttgacgtatc agcagaatca gcaaaagcaa 1988821 aataaaatgc agatcatctt ggttttcttc tcgatccact tgtttctcta aatccaaatc 1988881 atccctctcc cttatcctta tctctgtttc acaatatgtg cgacttcgat ttatggtata 1988941 ggctatgtcc actccattaa aaaatcagca ttttccttaa atagatgaaa aatagatcag 1989001 gtacggcgtt cgactcatac caaataacag ccggaagaat atgaataacg tgagttcact 1989061 atcgaatagg aggtgtgtgt aatgagctct gaaaatgcac agttaaaaaa ggatttaatt 1989121 aaagccgttt taagcccttt atttccaact gcaacagaag gaggagaaaa tatggatagt 1989181 aatcttaaag ccttgcttga tgctgccatc gatcaaaaag tagatgaaag tgaaacggtt 1989241 acggcagaat ctattttaga cccttctctt ccggcaagat ggatttttgc cagaattacg 1989301 ccaggcacta caatcagcat tgtgactgat tcaggtgaca tgatcggacc ggttgttttc 1989361 gttgctttcg atcaggttca cgggatcgta tttgtaacac aggaaagctc cgtcactccg 1989421 gcaggccaag ctacaacatt aattgatgta gacaaagtag aaagcgttac gttcttttca 1989481 taacatccga tgaaagtctt gtatatccag tcgggatacg gaggaatata cagttatttt 1989541 gatcgctggg ctgaagaatg ttttcagaac actcatacag agtatatgat tgcagataaa 1989601 cctgaagcag aatctttgat gaagatcgaa gcgtttcagc cggatttcac acttatgatg 1989661 gttggagacc gcgttcctca cgactggctg acctggttaa agggtaagga tatccccgtg 1989721 tatgtttggc tgaccgaaga cccattttat atggatatca gccttcaggt aattaagctt 1989781 gctgacgcca tattaacgat agaacaaaat gcagctctct actatcaaga gctcggctac 1989841 cagaacgtct attatgttcc gataccagtt aaccatcggc tgtttaaaaa aatgggcacc 1989901 gaacattcct atcattcaaa tctgttaatc atcggctatc cttaccctaa tcgggttcag 1989961 cttatgaaag aagcggtcca tctgccattc acggttcggg taatcggcaa ggaatgggga 1990021 aaatatctgc ctaaaaaagt gctcaaacag ccgcatattg atgtcgtcag cacatgggtt 1990081 ccacccgaac aggccgttca ttattataat ggggcagaca tcgtaattaa tgcgcatcgt 1990141 ccctatcatt ttgctttcaa ccaaaatact atgcgcatca aaaatgccag ttttaataac 1990201 cgaacgtttg atatcgctgc atgcgaagca tttcaattaa cagatttacc cgcggcgcat 1990261 cctttttcat ccattatttc ttatcacggc atgaacgact ttaaggaaaa agccgctttc 1990321 tatatcaacc accctgaaga acggcaaaaa gctgcagcag ccaattataa agagaccgta 1990381 cccgcattta cgtttgatga gcttcctgca aaactaaaag cgattcatct ggcgctttct 1990441 tgaaaaatcg ttcattgcta tgaacgattt ttttattcat agaaaaaagc agctgcacaa 1990501 gctgctttct attctagccg tcagaacggt ctttcagctt cctcggattt acctgtttat 1990561 gaagatcagg catttcgccg agatgctgtg caatttgttc ccacgataca attttgaaat 1990621 tttgattgac ggcttgtccg ttatcaatat tttcgccgtc ctgcgccaca aaaatcccgt 1990681 acggatattt tgggccaagt ccgaaaccga gaacatcaat accatccgtg tcactagtac 1990741 cgtctatctt ctcgccatct gtaatctcaa agttggctac atagcgattt ttcccctgcc 1990801 gttcatacat tgcatagctg ttatttcctt gacttgaagc catgagatat cctttgccat 1990861 ttggtgcata atagattgtc agtccttcaa tatcagctgt caaatgatct cctgtcgcac 1990921 ggtcaacaac ctgccccttt gaccctccgc cgggctcagc gttaaatttc cagatggcct 1990981 catcttcctc tgctatgtat aggtttccgt actcatcatc cgcaacaagg ccttcggtct 1991041 gagaattcaa cttaaattca cgcacctttt tccctgttac ataacccttt ccaccatcaa 1991101 caatttcata ctgctcaaat tccccttgtt tgcctgtcac taatgcgtaa aatgctcctg 1991161 ttttctggct gtgatacaag ctgaatccat aaacctcaga aatattggtg gaaataggat 1991221 ggttcggatc tgtaatgctt ttcaattttc ctttatcccc gtctattgca tatacttcaa 1991281 ttgtattttt tccttcggac cggttggatg cggcagcaat atcaattttt tcgccgttca 1991341 atggaaaatc atagcgcaga tcgacattat tgagcttgcc aaactcataa gaatgaagct 1991401 gttttccgtc taaatcatac acaacgagcc ctgacttctt atttgttgta atcaacttgc 1991461 ttttttccgg gtgtttttca tgaacccaaa tggccgggtc atctgctgca tcatcgccag 1991521 atgcgaccgg atctgtctcc gtgtgtgcag tcactttgaa atgatgttcc tcattcacat 1991581 aatgagccga caccgaggtt gctgtcaggc taagcaataa acccgcggca gtgcttagca 1991641 gcattgtttt tggaaccttc atttggtacc ctcctctttt atcactaaca ctactattgt 1991701 aaaatatata caggtgatta ccgtgaggaa aatgaacctt tttttatagg gtttctgact 1991761 cataaacaac ttattcccca aagaggtggt gagatgactt tgccagattt acttttgcgg 1991821 agcgaaataa aaatatgttg aatatttagt acattattta tttagttttg tttttcccta 1991881 gttacgtccg tttttccatt ttctattaaa aaagaacact ttgtgacatg atcattcccc 1991941 taaattttgt tttattggtt gctttcatta attcgattac aaagttgaac atatgatgca 1992001 tggtagagaa acgagagttg gaggataagc catgcctaaa cagcaaacag cagaactaaa 1992061 accatttttc cataacaaaa cagttttagt cactggcgga acgggttcaa tcgggagtca 1992121 aattgtcaaa cgccttttga tgcttacacc taaacaggtg attgtattca gcaaagacga 1992181 cagtaaacag tatgtcatga gccaaaagta tgcggaggat aagcggctat tatttgtact 1992241 tggagatgta cgcgatcaca gaagggtgaa tcaggtgatg aaaggcgtcg atatcgtctt 1992301 tcacgcggct gcgctgaaac aggttccgac atgtgaggac catccatttg aagcgatcca 1992361 gaccaatctc atcggcggac aaaatgtggt ggaagctgcc ctttcacacc gagtgcagca 1992421 tgtcattaat atcagtacag ataaagctgt atctcctgtg aacacaatgg gtgccaccaa 1992481 gctgttatct gaaaagctgt ttcatcaagc aaaccgccac gtccaaaaca aaggaacctt 1992541 gttttgttcg gtccgctttg gaaatgttct cggttccaga ggttcggtca tccccatatt 1992601 atttgaacag atgatggagg gtgaacctct gaccatcaca gacaaaaaca tgaccagatt 1992661 tttcatgtca atagacgatg cagctacatt gacattacaa tcggctgcta ttacaaaagg 1992721 cggagaaacc tttattttca aaatggaatc actgaaactt gaagaactga ttcatgggtt 1992781 tgaagaatat gcatcgcagc acgggctccc gcggccggct gcagtagaag tgggcaagcg 1992841 tccaggtgaa aagcttcacg aagaattaac atctccacat gaaattgaat cactgtatga 1992901 atggggcaac ctttatgcga tccttccaga gccggaaaaa catcctgact ttcgcaaagt 1992961 caatctgcct gggtatcaat cagatcaagc cccgctcatt acgaaagaaa gaattgctca 1993021 gattattgaa gaattgcatc aagagaaaaa ggcataaaaa caagcctgtc tatccattag 1993081 gcaggcctgt ttttaacagt ttatttatta aagagatgca gatagctttc gtatccttct 1993141 tcttttagct tatgcttcgg aacaaaccgc agcgctgctg aatttatgca gtaacgaagt 1993201 ccgtttggcc ccggtccgtc attaaatacg tggccaagat gagaatcagc agttcggctt 1993261 cttacttctg tgcgaatcat gccgtggctc gtgtccagtt tttcttccac ttcttcttca 1993321 atcggctttg taaagcttgg ccagccgcat tgggaatcaa atttatcttt ggatgtaaac 1993381 aatggcttgc ctgacacaat gtctacatac aacccttctt ccttatgatc ccaatattca 1993441 ttttgaaatg gcggctccgt gccgttattt tgcgttactt catattgcat gcgatttaat 1993501 gactttattt tttcttcttt attgtacgcc atttatttag ccccccaatg ctcgctgata 1993561 aatcccgctc gtccggaacc tgtccggtag cgctgataat gtgctggatt ctttttataa 1993621 aaatgctgat ggtagccttc cgcttcatag aaaggttcag cttttaaaat gtccgttaca 1993681 atcggatctt taaagatgcc gctttccgcc agacgttgct tggaagcttc cgcaagctcc 1993741 ttttgtttat cattatgata aaaaatggct gcgcgatagg aactgccgcg atcagcaaat 1993801 tgccctccgg catctgtcgg atcgatttgc tgccaaaata attcaagcag tttttcataa 1993861 gggaatacat caggatgaaa cgtgatttga acggcttcac gatgtcccgt cgtttcactg 1993921 cacacctctt cgtacgtagg gttttcagta tggccgcctg tatacccgga caccactttt 1993981 tcaattcccg gctgttcgtc aaaaggttta accatacacc aaaaacagcc tcctgcaaat 1994041 gtggcgattt cttttttttc agacatactg gtgcctcctt tgttaatacg tggtattatt 1994101 atattatagc atgtaaaaat agaatgaaaa tgattctgct tttcaataaa atctataggt 1994161 tttaagcaat atgcttatgt aatggaggtt cacaaatttg aaagtaagaa cacagatgat 1994221 gtacgatatg gaaactttac tccgtaaagt ctttaaacaa atacgcaatg aaatcaatga 1994281 aattttagat aaagagctgt cgcggaatga attcaccatt cttcgaatcc ttagtgaaca 1994341 agggcctaaa aaagtcactg aatttgcgcc tattttagag gtatcggcaa gccacattac 1994401 ggctgtgacc gatgcgctgg tagaaaagga atggattacg agaatcagat cgaaggaaga 1994461 cagacgcatc atccgcattc atatcactga agcgggcgaa aaagtccttc agcactttaa 1994521 cgagaaaaaa acggaatatt tctttaaacg ctttgactgc tacactgatg ctgaacttgc 1994581 cacgttaatc gagctcttca gcaaacttga taaaaaacgg tgaaaaaaag cacataccga 1994641 tatataggta tgtgcttttc gcagtgcttc acttattttt cagtaaacag cttcattgct 1994701 ttccagcggc catatctata atacaaaaat gccgcgcagc tgctaaataa aaaactcatt 1994761 ccgattccaa gcccgattcc tttttgtcca agccaagctg aaaatagagc tgtgaaagga 1994821 tacctcaaca cccaaaacga gatcaaattt aataccagaa cctgcagcat cgctcccgcg 1994881 gccctgacga ttccgttcag cacaaaatta accccaataa aagggtagaa aaacgcgatc 1994941 cacttcaaat attgttcacc aaatgcgacc gcatcaggct cactgataaa taaccttatg 1995001 aggtatttac caaataccca aatcataacc gcaatcacca gcatgcagga aataacagct 1995061 atcacaccta gccttgcaat tgttcccact cttttttcgt ttccgattcc aatattttgc 1995121 cctgccatac tattgacggc cgtaccggca gccattgctg gaagcgtgat gatgctatca 1995181 agccgctgca ccgcgccaaa gcctgatacc acgtgatccc cgtatgagtt aacaacactc 1995241 ataatcgcca tcataccgcc tgtaatcacc atcatctgca gacctgccgg aatcccgagt 1995301 ttcaaaatca gcgcggactc ttcccacttg ggcattctcg gaatcgagaa tggcacaagc 1995361 ttgtgtttga tgacataaaa caacccatac aaaaacgcaa tgccctgtga caaaatcgtt 1995421 gaataagccg ctcccgctat tcccatgcgg aacacagaaa taaagagcgg cgcaagcact 1995481 gtattcagta caacagcaaa cgcaataaac cggagaggtg tcttgctgtc gcccagcgca 1995541 cgaagcacag tactgataaa gttataacca aacaaaaata aaatgccgat aaattgaatc 1995601 tgtaaatacg tctcagcaag cggtatcatt gactccggcg tttttagaag acgcagcaaa 1995661 agctctgaga gaaaaaaacc ggccgcgccg aatccgatgc ttaggcctgt taataaaaca 1995721 acaaaagcgt taatatacga cgccattcct tttatatcat cttttccttt ttgctgagat 1995781 aaaatggtta acgtcgcatt gttaaggccc aaaataaaag acagcacggt caaaacaatc 1995841 gtgcttgata ccgcggctgc cccaagggcc tttgccccca gtaaattgcc gatccacaag 1995901 ctgtctataa attgaaagga aacctgcaat gcgtttccga gcataatagg cattgaaaac 1995961 agtacaagct gtttcagcac gttcccctgt gtaaaatcgt atgctttcat cttttctcct 1996021 tgtgttctca aattttcttc ggaccacacg aaaaaagaga cgttgtttca tgtctctttt 1996081 ttcatgactt atcggttttt tttcggtctc gcataccgaa tgtaaacacc atcacactta 1996141 ggaacaaggc acaataggaa acattcaaat acatttgatc catatcttca gcagccagat 1996201 gatgataagc aagccagccg aagtacaggg aaaatgtaaa ggataataaa ctgaaatact 1996261 ggtaaatccg tttcattttc agtcacctct attgtttagg atggtaatag gaaaactcaa 1996321 tttcatcttt ttctaaattt atcttatccg ctttgacata cattccattc gttaaaggca 1996381 tttctgacaa acgcacttca atgcttttat ctccggggtg aacatggaca aatgacggca 1996441 attcataaaa gctgtccata taatttaaca caaagctaat tggtatactc aatttcccta 1996501 acgaaaattt cgtgacattc agctctacat caccgttttt tttcacggtc ggctcaaaag 1996561 cgataaacgc atcaatagac gtggaaaatg ccttgatttt ccctgcgaca tgaacatcat 1996621 catcaatctc tactttataa tcaagcttgt ttgatgcttt gtcgtttaaa tatgagttaa 1996681 caaacgcagc taatgattct tttgtgcttg tcacttgaaa tccatactcg ctctcagatg 1996741 catctttcac ctgagcctgt tcccccggaa gcaaaacaag tgccacaaac ccggcggcga 1996801 ggataaaatt gattgcaagc aatataaaaa acagtcgctt ccacttattc atgctgtcac 1996861 cctactcttt cggtaatcct tcttttttaa tggcttgata gacgcgcttt gcgataagag 1996921 aataacccgt accattagga tgaaaatcat cttcctcaga aattcggctg ctgtcacttt 1996981 tttgattaaa caaatcttcg atatggacga tttttgcatg tttatctttt ttcagctctt 1997041 tttcagcaat atggttccaa tccgtgacga caccatttat ttcatttagt tctgataatg 1997101 taaacgtaaa cggattgtac atgctgacat aaatcagctc agcgtgatca ttcagctcgc 1997161 gaatttcaga aatgattttt tcaaagcgct tttcgtacgg tttttccgct tcctgaaacg 1997221 gttcaacggt taattgcaga aagttttggc gaaggatttt catcaaatca ttaccgccaa 1997281 ttgtaaaaaa gacataatct gcgtccttta tgcctttttg aaccttttta tcttttagtt 1997341 tttctaataa atcatccgaa cggttccctt ttacagcata atttttcacg tcgaccgttt 1997401 tgacttgttt atctgaccgg atagaatccg ccaccttgcc gacatatccc tttccgtcgg 1997461 gatctccgac tccttctgtc agcgaatctc cgacagccgc tatgacaatg tgttcttttg 1997521 ttttcgtttc atgggctttt tgttttccct cagatgatgt acgtatgctc gtacacgcag 1997581 taagaagcaa aatcaaactg gccatgattg aaaaaatgcg cagcttcaat cttgttgctc 1997641 cttcccattc tactagtgga aagtgtatca tgttttagaa gatttgcaaa tgcctagtct 1997701 cttagcttac ttgagtgtac tggctgactt cacatcggaa atgatatcat cgtacggtgt 1997761 attctccact ccattgtaat ctttcagcac cttaccgtcc ggacctacca aataaaaaga 1997821 agattgatga atcacttggt cctctccctc cggcttcttt acgatcgctt taaagctctt 1997881 aagtgcgaac tcctcaatct cactctggct gtatcccgtg agaaaatccc agttatcaaa 1997941 agataatgga taatttgcgg caaatttctt cagctgtttc ggcttatcgt tttctggatc 1998001 aacactaaat gatatgatgc ggacatctat attttcggct ttcagttttt tttgcagatc 1998061 ggtcatatga gcggtcattg gcggacatat agtttcacaa ttggtaaaaa taaaatccgc 1998121 cagccatact tctcctttta aactctctaa agaaacgttc ttgccgtctt ggttttgaaa 1998181 tgtaaaaggc tccacctcgt aattgagcgg atctttaatc tgctgtcctc cgcatgcaca 1998241 caaaaacaga aaaatcagcc cagccgttaa ccccttgata accttcatga catccatcct 1998301 ttccagccag cataaaaacg ctttctaaaa ccgtccttac tgtcccatgt ttgtattcga 1998361 tactgagcaa aaaaaatcct gcatgcctcc ccattaacga ttacaaagga gggcatgcag 1998421 gtaaaaaacg gcatgttacg cgttgtgctt taacacctct tgatgaaata cagcctgata 1998481 atctgcccac ttcatccgcc gcttcatata atgtcggaaa gaatacactt ttgccctgct 1998541 gtttgatgaa aacacttctt ttaagtagaa ttgcaaatgg tgatgtaaca taaagaaata 1998601 gtgctcatct tcctttaata caggtatttc tgtcactttc acctgaatcc cgtcaccgcg 1998661 tttgaactct aggcttttga gtaacaagct atcaatcctc ttttttgttt ttcttctatt 1998721 atatatgatg ccagccgggc tgtctgtcat tttgcgcggt tgtgtaaaaa aattagatta 1998781 gcaaatggaa caagtcctca tccttgttca cctctacata atgaaacggt tttttgttca 1998841 tccgttcaat cagcggccca taatcggctt tgttctgcag ctcgatgccg acaagagcag 1998901 gtccattgct tttattattt ttcttcgtat attcaaacct tgtaatgtca tcattcggcc 1998961 cgaggacttc gtcaagaaat tcgcggagcg cccccgctct ttgtggaaaa ttgacgataa 1999021 aataatgctg aaggccttca aaaatcaagg aacgctcctt catttcctgc attcttccga 1999081 tatcgttatt gcccccgctt accacacaca ccacgttttt ccctttaatt tgatccttgt 1999141 acaaatcaag cgctgcgaca gaaagagctc cagccggttc agcaacaacc gcacattcgt 1999201 tatataattc aagaatggat gtacatactt ttccttcagg cacaaggaga atgtcatcaa 1999261 cgacagtttc cagcgtccgg aaggtttcct cgccaatttt tttaacagcc gccccatcta 1999321 caaacttatc aattttatca agtgtgacga catgcccagc tttgtttgat tcaaagtagg 1999381 atgccgctcc cgccggctca acagcaatta cctttgtatc aggagacacg tttttcaaat 1999441 atgtacctac cccagagaga aggccgccgc ctccgacact tgcaaaaaga aaatgcggtt 1999501 ctgtatcaat gtcgtttaaa atctcgactg cgagcgttcc ctgtccggcc atcacatccg 1999561 gatcatcgaa cggatggata aacgtccgag attccgcctc acagcattca gcagcgcttt 1999621 tatacgcgtc gtcaaacgta tcgcctgtca aaataatatc gataaatcct tttccgaata 1999681 gttcaacttg agatactttt tgtctcggtg tagtagacgg cataaaaatt ttcccgtgaa 1999741 tgccaagatg tttacacgaa aatgccacac cttgagcgtg gtttccggca cttgcacaca 1999801 caactccgtt ctctgtctgc tcgctggaaa gctgtttcat tttatgataa gcccctctga 1999861 gcttaaaaga tctgacaact tgcaagtctt cgcgttttaa atagatattg cattcatatc 1999921 tctcagaaag tctgtcattc ctctgcaaag gtgtgtgaat gacaacgtcc tttacgtttt 1999981 ggtgagcctt caaaatgtct ttcacttgga tgagagagtt ttctttaagc aacggtttca 2000041 tgtacagatt cctttcttgt tttaaatccc tatttaatat gccattataa catgaatatt 2000101 caaaaaataa gacaattatt tttatttaat aattaaaaaa atacagacta tgtccaccac 2000161 atcttgtggt aacttctgtt caaccattat cctgcagagc caagaaaaaa gatgatcgta 2000221 aaataaaggg tgttttcaac caaaaggcat gatataatga aaccaattag aaccaaaagg 2000281 agccaattga tgaatagtgc accaaaactc aatacatttc aacatctaat cggagaacat 2000341 caaacttttc tggaagcgaa gcgaatcgcc aagcagttct cgttatcgga gcttcctgtc 2000401 ttaataacag gaaaaatcgg aacaggcaaa aatcacttcg cacatgccat acacttggaa 2000461 tcttcgagaa gcaatgaacc gtttataagc gtcaattgca gcacccattc ggaagaaacc 2000521 cttattcatg agctttttgg ccctaacgga aacacaggtg tttttcaaaa agcggtacga 2000581 ggaacccttt ttcttgatga tgtatggcgc atgcctgctt ctgtacaagc tcagctgtta 2000641 aaagcgcttg attcagacac ggagaaaccg cgaatgatct gtgcttctgc agaccgatcc 2000701 gtggaacata cattcaggca agacttattc tacagactga acattttaac gctcacactg 2000761 cccgaattat cggaacgaaa aagcgatatt ccgcttttga cacagcattt tctctcaaat 2000821 tctggtcagc aattgttaat cgatccctcc gtttttcccg tgcttgagaa gcatgcattt 2000881 gaaggcaatg tcagggaatt aaaaaacgct gcagattata tggcggcagt atcaagcggg 2000941 ggaacgattc agccatatga cctgccgccg tatattagag gcacgataga cggaaaaacg 2001001 tcgaagaaaa aagcgaaact gcttacttta atggaaaaag ctgagttttt gtttattttg 2001061 gaaacaataa aagtattgaa cgaaaaagga gaacctgcca gcagacggat catttctgaa 2001121 cacagcaaaa atacccaaac ctcgttaact cctcagcagg tcagaagccg tctcgactat 2001181 ttggagaaaa aagattatgt caccaaaagc cgcggacgcg caggcacaaa aattaccttt 2001241 gagggcttga gctttataga gacgttaaaa aatcaaatga tctagcgatc gaaaggagaa 2001301 tgtacttgtt tacaatcaaa gaagagatcg ccaatgcgat tacacacggc atcggtgtcc 2001361 tcttatccat cccagcatta gtgtttctaa tcatatttgc ggctaattac gggtctgcat 2001421 gggacattgt cagctttaca atattcggtg tctctatgct gctgttatat ttgagctcca 2001481 ccctgcttca cagcatcaca cataaaaaaa cgaaggacat tttggagatt attgatcata 2001541 gcgcaattta cgtactcatc gccggaacct acacgccttt tttgcttggg ccgctgaaag 2001601 gcacactcgg ctttaccctg ttggttatcg tatggtcact tgccctaggc ggaatcgttt 2001661 ttaaaatttt ctttgtgaaa cggtttatcc tattgtcaac cttcgtgtat ttagtcatgg 2001721 ggtggctgat gattattgca gttaaacctt tatatgcttc actgagcgga gcgggattca 2001781 gcctcctttt tctcggcggc attttatact ctgtcggaac catcttttac atttggaaaa 2001841 agatcccctt ccatcacgcc atttggcaca gctttgtatt gggcgggagc gctgccatgt 2001901 ttttctgcgt gctcttctat tgtgtaaagg tgcctttcct ttcgtaacag taacagaaaa 2001961 gcgcagtctt cacgactgcg cttttttatg cacgtaattg tttttcattg gcaggtatat 2002021 aagcttttga aaaggacaat tcaatgtctg ccggttttaa gcgtttaaaa aacgagccat 2002081 tttgcatgtt atctgttcct ttcgtttcca ccatcaccaa cggaagatga tagcgggccg 2002141 caagttctac aggatcaata gaaccatcta gtgaaagaat caggctttgt cccttttcca 2002201 gctgttttgt cacatcttca tatacctttt ctgaatcccc gtctgaaatc acatccatcc 2002261 gatccagcca ttgcccgata aaaggcaagc ggaacacttt tgggttagcg ataaagccgg 2002321 ccggttcctc aatatatcca gcaattaagg ccagttcagc caaacgcaaa cggggatgca 2002381 catacaaaac aggaccgtgt ggtattggct ctggctgatg gatcgtcaca actgaaccgg 2002441 agatgccgat acagccttct aaaaacgcct ttggctgttc gtacacaaga gccatctgtt 2002501 ttttgtatga cagacgggga tcgagcattg tttgattaaa taattgtttc atatttttta 2002561 acagcatata cacaatataa accactagaa ggctgtagcg aaccaattaa aatcctcccg 2002621 ctttagaaga attctttttt tcatacatta gaaattcgta atcatacggg tttttttcgt 2002681 ctttggtccc ctgctcagaa gaaaccagct tccaattgga ttcatcaaat tcaggaaagt 2002741 gacggtcacc ctcaaactcg tgatgaattt tcgtcatata cagtctgtcc gcataaggga 2002801 acaggtccgt atagagctga gcccctccga tcacaaagca ttcttcaggg cctgaacaaa 2002861 tgtccagtac atcctttaat gaactgacaa ccgtgcatcc ctgaaattct gaatccggcg 2002921 ctgaggtaac gacaatattt ttccgatttg gaagcggacg tccgatcgat tcaaatgttt 2002981 tccggcccat aatgattgaa tggcccgatg ttattttctt aaagtatgca agatcattgg 2003041 gcaaatgcca cggcaaatca ttgtctttgc cgataagcct gttggcatcc atcgcaaaaa 2003101 tgaatgaaat catacgctga ccgccccttt tatatgagga tgcggatcat aatcctcgat 2003161 gataaagtcc tcaaatgcaa agttaaaaat agaatcaacc tttctggcga aacgaagctg 2003221 cggaagcggt ctaacatctc tttccagctg caaattgact tgttcaatat gattttggta 2003281 aatatgaaca tcaccaaacg tatggatgaa ctcgcccggt tcaagcccag tcacatgagc 2003341 aatgatcatg gttaggaggg cataagatgc aatattaaac ggcacaccta agaaaacatc 2003401 ggcagagcgc tgatacagct gacaggacag cttgccgtca gacacataga attggaacag 2003461 gcaatggcac ggcggcaacg ccattttatc aatttcacca acattccagg cgctgacgat 2003521 taagcgtctg gagttcggat ttgttttaat atcttcaata agacgggaaa tttgatcaat 2003581 ggtttctcca tcagctcccc gccaagaacg ccattgggag ccatatacag gtccaagttc 2003641 accgttttca tcagcccact cattccagat tcgcactccg ttttcctgca gatagcgtac 2003701 attcgtatct ccttttaaga accacagcag ttcatgcgca attgatttaa agtggagttt 2003761 tttagtggtg agcatcggaa agccttcccg taaattaaat ctcatttgat atccgaaagt 2003821 gctgattgtt ccggtcccag tccggtctcc ctttttctca ccatgctcta aaacatgtct 2003881 gcagaaatcc ttatactgtt tcattttttt catcctttaa aagtagtctt ctagtagtgt 2003941 aacacaataa aaaatcattt ctgaacccag aaatgatttt tttatagtca gctgacgaca 2004001 ggcttttcat cctgttcttt ttcttcatct tgcagatcct gatgcgtatg tgcaattctg 2004061 ctcgccgctg ctgcagcaag agctgccaca atatcatcca aaaaggtgtg aataccgtct 2004121 ggactttcat caagttcctt aataattcca atcttctctt tatccaaata accgaaattg 2004181 gtcaaaccga tcgacccgta cacattaacg attgaaagcg ggataatttc atctatgccg 2004241 taaagcggtt catccgtttc aacaaggtgc tgcagcggtt cggggagaag tttctgttct 2004301 gcaagctgat cgagtgcaag gcctgtcaaa acagcatgaa taatttcacg tttgttcagg 2004361 actttttcta cattctccat gcaaacactg agcggcagat ttggattgta tttttcctga 2004421 agtttttgaa caatccgtgc aatatcttct atcataacgc cccgtttgtt cagcatatcc 2004481 tttgttatat cgaccatttc attcattgtg tactttttca tgtctaatgg catctccttt 2004541 aggcactcat ccagttggga ggcgtgttgc ggtcccagta aatgctccca agctcatgat 2004601 gtgattgaaa tccatcttct gctgtatgat aatgaaaatt aaaccagtag ccgtcatgag 2004661 gcgggtggtc tcttcgcaca tggaatctga gaagatcttc tccagttgtc cgattgtaaa 2004721 cgttgaaaat tttttccgtt ttgcccgctg aaggcatgct tgagatcaca acatcttggt 2004781 acgcctcatc atcttgcaat gtcgctaaat aatcactaat cacattttcg atttttggca 2004841 ggatctcttt ccgatagtca tcctcaatga caggagcgat tctgctgccg aattttaaaa 2004901 aggactgatc ctcagcgctg tcaaggagct gttccttgta cgattgaaaa agcagttcag 2004961 gatctcgcct gtcatccgac tcatcatcgt acaggtcatg ctcatcataa aaagcggtgt 2005021 aatcattctg ctcaagactg ctcggctgtc cggaaggctt gtccgccata agggcagccg 2005081 gaggagatac gagcccgaac gttacaatgg taaataaaac cacaagggtc tttctcatcc 2005141 acaatttcat gactgcttat tcctctctat tttattgtca tgtttctctt attttagcac 2005201 atccaaaaca tgcaagtcat gtactatatg aaactgatat gcaaattagg agattcgttg 2005261 ctatgcactt tgtgtaaaaa cgcttacaat atttcatgaa aggaggcttt ccgcatgatt 2005321 gacgctctgt ttgccacagt ttcactctta acattattat actttgtcgt catggaggtc 2005381 accgattaac agaaagcccg tgatatgaat cacgggcttg tttgaatgac gccataatgg 2005441 aacagtgctg tttttctttt catgacgtta aaaccaaact gttcaaaccg cgggcttttc 2005501 cagtggtctt ttagcacaac gctttttctg gcgactcgta ccgcttcatt gatacatcct 2005561 tcgtgcaaaa cggaatcctc tgccaaatca cgtaaaggcg cgatgccgtc agaggtttct 2005621 acaggttcat gaaacattgg atcgaaataa accacatcaa cagagttgtc agggagctgc 2005681 ttgatgtgtt caaagcaatc accattcttc acctggattc ttctcatcgc agcttgaagc 2005741 tcttctatac ccgtttccca tgaatgcagc cccgtcctca ctaaaacaga cacaagatgg 2005801 tttttttcaa tcccaacaac agaacccgtt tcgcctactg ccatacttgc gataatggca 2005861 tctgacccca acccgagtgt gcaatctaaa aacgtatccc cttcagataa gccggcagcc 2005921 cgaagcatag gttctttctc cccctgtaag aagcgtttgg ctctgaacat cgctgtattc 2005981 ggatgaaaaa agaatttggc accttgtttc gtatacagct caaaccgctc tttgccgacc 2006041 acaagcaaat cacgttcagc tgatttcagc aggtgctcaa ccgtttgttt attccggccg 2006101 cagtatggca tatttagctc tttagaaagc tgctttgcag tttttatggt gtgttcagac 2006161 ggtctatagc ttgttgttat catcttctgt actcccaaaa agaaaatgcc cggagaacgg 2006221 gcatttagca gtgcgcatcg aaggcagcag tcagattttt catgatttct tccatatcgt 2006281 gtccttcaat ttcatgacgc ggaataaaat gtacgacttc tttgcctttc aaaagagcca 2006341 ttgatggtga agaaggctcc tggccagtaa aatactcacg cattttcgca gtagcttctt 2006401 tatcttggcc cgcaaataca gtcaccgtat tgtcaggtgt tttgtcattc tggaggactg 2006461 cctgtgtagc cgcaggacgc gcaaggcctg ccgcgcagcc gcatacagag ttaacgacta 2006521 caagagttgt gccctctgcc ttttccataa agttttctac ttcttccgct gttgttaact 2006581 cttcaaaacc tgctccagtc agctcgcggc gcatcggtac gacaagctgg cgcatgtatt 2006641 cttcataagc cattgacata aaaaaagccc cctctagtat ccttcatctg aagtaaagga 2006701 tactatagag agggccggat ttcaaatgtt cacgccttaa aataaaagaa agtgtcccca 2006761 gctatctaga ttttcataat accgccggtg ttggcacttg tcacaagttt agaataacgt 2006821 gccaggtagc cggttttcac tttcggttca aaacctttcc agttcgcttt tcgtttttcc 2006881 cactcttctt ctggcacttg tacatccaag atgcgttttt caatatcaac gataatatgg 2006941 tctccgtttt caacaaaggc aagcggcccg ccctcagcgg cctcaggtga tacgtggccg 2007001 attgagaggc cacgggaggc tccggaaaaa cgtccgtccg taatcaatgc cacttttggc 2007061 ccgagtccca ttccaacgat ttgggatgtt ggcgccagca tttccggcat gccaggtccg 2007121 ccttttggcc cttcgtatct gatgatgaca acgtcgcctt cttttacttt tcggttgata 2007181 atgccgtcaa gcgcctcgtc ctgagaatcg aatacgacag ccggcccttc gtgtcttgta 2007241 atcccattct gtacgccgcc tgttttaatg atagcgccgt ccggagctag attaccgaat 2007301 aaaacagcaa ggcctccctt ttcagtgaat ggttgatcca gcgggtgaat gacgtcataa 2007361 tcctttactt catgtccggc aatggtttct ccaagagttt ttcctgtaac agtcagcgca 2007421 tctaaatgaa gcgctccttc tttcttcgaa agctcattca gagccgctga aacgccgccc 2007481 gcttcgtgaa gatcttcaat aaacacatcc gatgcaggcg ccagcttagc caagtgcggc 2007541 acgcgctcag cgacttcgtt aatgcgttct aaagagtatt caacgccggc ttcgtttgca 2007601 agggcaaggg tatgaagaac ggtatttgta gaacctccga gcgccatatc gagtgcaaac 2007661 gcgttatcaa tcgcttttac tgtaacaata tcacgcggtt tgatatcttt gcgaatcgtt 2007721 tccattaatt gcgcagccga ttttctcaca aactctttgc gttccggaga tgttgccaga 2007781 atggttccat tacccggcaa agcaagacca agtgcttctg acagacagtt cattgagttc 2007841 gccgtaaaca tgcctgagca agacccgcac gttgggcatc cgaactgctc tagttcttga 2007901 agctcgtttt cgttgatttt ccctgcttgg taggcgccta ccccttcgaa tactgaggaa 2007961 agggagattt ttcgcccgtc acttgttctt cctgccgcca tcggtccgcc gctgacaaaa 2008021 atcgtcggaa tgttgatgcg cattgccgcc ataagcattc ccggtgtgat tttgtcgcag 2008081 ttcggaatac agaccattcc gtcaaaccag tgtgcggata caaccgtttc cacagagtct 2008141 gcgataattt cacggcttgg cagcgaatat ctcataccga tatgccccat tgcgatgcca 2008201 tcatctaccc caatggtatt aaattcaaac ggaacgcccc ctgcttctct gattgcttct 2008261 tttacgattt tcccaaactc ctgcaagtga acatgaccgg gaacgatatc aatgtatgaa 2008321 ttacacaccg caataaacgg cttgccgaaa tcctcttctt ttacccctgc tgcacgaagc 2008381 aaactgcggt gcggagctct atcgattcct tgtgtgatca tattactgcg taattctgcc 2008441 atggtgatcc tcctaaattc tttcaattgt ttgattggat tttattttga caattttcag 2008501 tttatttatg ggctgttttt gcaaataaga taaatacagg ccgccctcac cttgttttgt 2008561 tctttcgtgt ttttatattt atatagcttt ctttcgattt gaaccctcca actattaata 2008621 ttgttactta ctataaatag ttttcggata tttttcaaca atattcgaaa taatttttat 2008681 aaaaagtgaa ttcacataaa aaaggtgcat gatctgcacc ttttttatct ttattcgcct 2008741 ttttttctgc tttccgtcat ttgtttccaa acagaacctt ttgcttcttc tccatgctca 2008801 atacgttcaa gcgccatttt gacttgaagg ctgacctcaa attcggggtc atcttcggca 2008861 gcgcgcaaag cttcaattgc actttcatcg ccgacttcgt acaggaacat ggcggcacgc 2008921 cagcgaacaa gcttgctgga gtcgcttaat gacttgatca tagcaggaat ggcttgagga 2008981 tcgccgatat cagacaggca gtctccggcc gttcttctga ctgatacagc tttgtcctca 2009041 agtgctttat acaatagagg aagaacatca ggtgtttcaa tcattcctaa gtacacaaca 2009101 gcctgtcttc tgatggacac ctttggatca tccaatgcct tctgtaaaac cgggatatcc 2009161 tcttctttcg gatccatctg ttccaagtgt gcataacgct ttttccagtc ctcatcatcc 2009221 agcatatcaa gcgttacttt atacgctttg cgctgtacag cttgttttgc ttcgcccttt 2009281 ccttgagcgg ctgcttcagt cagtcgtttc agccgttcat cactgtatgc cgcttgaagc 2009341 tcttctgtca catcatggcc gatttcatca aagtcaccga atctgacacc ttgttctttc 2009401 caagcccgct caaacacaac attggaagct tcagatctaa gttttaagat cgcctgctga 2009461 aagcgttcag gtaagccgaa gcgttcttcc cgctctccat cggttaattt aacttgcata 2009521 ggaatgccgc tgaacatctg cacaaaaact tttacctctc caaaagattc ttgatcagaa 2009581 cgattttctt ctgcgctttc agcactttcc atcccaaatg cagtgcggac ttgcggtaaa 2009641 atgtctttcc agtcgtatct tgcattccgt tcaacagcaa gaaaatctgc gacgtgatat 2009701 acccctttaa ctccatctat tttaaggatt tccgctataa caagcggtgc gccttctgct 2009761 tgctcaggtt tatagttatt gcttttgccc gccggaagct cttccgttaa gatgactttc 2009821 attgtattcg ggcttggtgt aggttcaatt gattttatct tcatgatcgt cctcctatag 2009881 catatctgtg acttattcta tcatagtcgc tccaagcctt ctattacgac gtttcggcat 2009941 caatcccggg tatgtctttt tctaattggc ggacaaattg aagcataaaa ttgtgtcttt 2010001 cttctgccag ttcccgtgca gtgtctgtat tcatcatatc tttcagccgc agcagcttat 2010061 gaaaaaaatg agcgtaggcg ctttgctcat ctccataaag gccatgccct tttgcgcccg 2010121 caaacatgaa agctctcgca atgccgacag caccaatcgc atcaagtctg tcagcatcct 2010181 gtacagcttt tccttcaatt gagagcggct ccttcgccaa tttccccctg tcccgaaagg 2010241 acatccttgt tataatatga atcaccctgt cagcattctc ttttcctact ccgaaaaaaa 2010301 cgagctgatc atatacttcg ctcacagaaa gcctgaccgt gtcaggcagc ttcacatcaa 2010361 ttaaatcatg aaccaaagcc gccgtttcaa caatgaacaa atccgctttt tccttttctc 2010421 caatatacgc tgcaagatct gctactcttg atacatgatg ccagtcatgt ccagagcttt 2010481 cgtcagtcag gatagattga acccatgtcc tgatttgctc tgcctgcttc aattccttca 2010541 caaaaacacc ctctttttat tgctctaata gcttcacgat atcgtcttcc aactctttcg 2010601 gatttgtatt tggtgaataa cggccaacga tttctccatt tctatccact ataaatttcg 2010661 tgaaattcca cttgatcgcc ttagttccca gcatcccttt cgcatgttct gtcaaataca 2010721 caaacagcgg gtgggcgttt ttcccgttta catccacttt tgaaaacata ggaaatgtaa 2010781 caccgtaatt tgtttcacaa aattcctgta tgtcagcctc ttcaccaggc tcttggttca 2010841 tgaattgatt gcaggggaac cctaagatct ccagcccctc ctgctgatat gtatcatata 2010901 attcctgcag ctgcttcaat tgggaagtaa aaccgcactt acttgctgta ttcacgatca 2010961 tcagtacctt tcccgcgaaa ggctgaagtg tcatgtcttt ccctgtgatt gtacgtacct 2011021 tcatatgata aatagacatg taagtccctc ctatgtcctt ggtgctgatt attttacctt 2011081 ttttaaatcg caattcaaaa tgtaaacatc aattaagaac tcataagaaa cctaacgata 2011141 tgagcgtcag ttcattatca attcatatgg ctcgtttttt atcttatcat tctataaaac 2011201 attacaattc cctcttacat ctttgaaaat cattttactg tgaaaccaaa aggcgtgtca 2011261 gtgcgtttta tttaaagagt tttctgttgt ttccccctca acacgtatag atagattgaa 2011321 aattggcgtg aaaattccta taatgaagaa aattaaacgg ggaaataatg gaggtggcac 2011381 gttgcctatt aatataccaa cacacctgcc ggcaaaacag gtgcttgaaa gtgaacatat 2011441 atttgtaatg gatgaaagca gagcatttca tcaggatatc cggccgcaaa aaattattat 2011501 attaaatttg atgccgaaaa aaatccaaac agagactcag cttctcagat tgcttggaaa 2011561 ttcgccttta caggttcatt tcacattttt aatcccaagc acacacacgc cgaaaaatac 2011621 tgcgagagaa caccttgacg aattttacac gactttttcc aatatccgtc acaagaggtt 2011681 tgacggcatg attatcaccg gtgcgccgat cgagcatttg gcgtttgaag aggtttcata 2011741 ttgggaagag ctcaaggaaa tcatggagtg gagcaaaaca aatgtcactt caaccttgca 2011801 tatttgctgg ggtgctcaag caggtttgta ttaccattac ggtgtggaaa aaattcaaat 2011861 gccgaaaaaa atcttcggtg tgttcgaaca taccgttctt tcaaaacacg aaagattggt 2011921 aagaggtttt gacgagctat actacgtgcc gcattcccgg catacagata taaatatgga 2011981 acagcttcaa gcagtgcccg agttaaacat tcttaccgca tcaaaggaag ccggggtttg 2012041 cttaattgtg tctaaagacg aaaaacaagt ctttttgaca gggcaccctg aatatgatac 2012101 aaatacgctt cttcaagagt atgaaagaga tttggaacga aacctttcta ctgtcgaggc 2012161 ccctaaacat tattttgcaa aaggcagcaa cgagccagtg aatcgctgga aagcgcatgc 2012221 cacattattg tttatgaatt ggctgaatta ttacgtttac caagaaactc cttatgaatg 2012281 ggactaattt ttcttttttt agtgatacgc tgagcaaaaa atatgataaa atacatctga 2012341 ttcagtctgc gtataacaaa aatttaaaat actggaatcc aaatcattta aaattagctt 2012401 aactttttca ctgcattaat aattcgatta tgtatttgtg ttatgtttat gtatagacaa 2012461 taactcctta cgatgcatga agcttgcttg ttgttgatta cattgaggtg aatttacttg 2012521 aataccaata aaagagtatt aattttgact gcaaattacg gaaatggaca tgtgcaggta 2012581 gccaaaacac tttatgaaca atgtgtacgg ctcggctttc agcatgtaac agtttctaat 2012641 ttgtaccaag agtcaaatcc gattgtttca gaggtaactc aataccttta tttaaaaagc 2012701 ttctcaatcg ggaaacagtt ttatcgtttg ttttattacg gagttgacaa aatctataat 2012761 aaacgtaaat tcaatattta ctttaaaatg ggtaataaaa gattgggcga acttgtcgat 2012821 gaacatcagc ccgatattat tattaataca tttccgatga tcgtcgtgcc ggaatacaga 2012881 cgccgaactg gaagagtcat tcctaccttc aacgttatga ctgatttttg tcttcataaa 2012941 atttgggttc acgaaaacgt ggataaatat tatgtggcga cagattacgt gaaggaaaaa 2013001 ctgctggaga tcggcactca tccaagcaat gtaaaaatca caggaattcc aatcaggccg 2013061 caatttgaag aatccatgcc tgttggcccg atatataaaa agtacaatct ttcaccaaac 2013121 aaaaaagtgc ttctgatcat ggcaggtgct cacggtgtat taaagaacgt aaaagagctg 2013181 tgcgaaaacc ttgtcaagga tgaccaagtg caagtagttg tcgtgtgcgg gaaaaatacg 2013241 gctttaaaag aatctttgag tgcgcttgaa gcggaaaatg gtgacaaatt aaaagttctg 2013301 ggctatgtgg agcgcattga tgagctattt cggatcacag attgcatgat taccaagccc 2013361 ggcggcatta ctttgacaga agccacagcc attggagtgc ctgtcattct gtacaaaccc 2013421 gtgcctggcc aggaaaaaga aaatgcaaac ttctttgaag accgcggagc tgccatcgtt 2013481 gtgaaccgtc atgaagagat tctcgagtca gtcacttccc ttcttgcaga tgaagatacc 2013541 ttgcatcgca tgaagaaaaa cattaaggac cttcatttag caaactcctc tgaagtgatt 2013601 ttagaggata tcctgaagga atcagaaatg atgaccgcca aacaaaaagc caaagtgcta 2013661 tcgtaatggc gtacttgaga gcatacgaaa atcgtgtgct ctttttattt atattcagcc 2013721 atcaataaaa gcggttacat ttttttatgg aacttgccct tcttttgaaa aataagccgt 2013781 ttcgcaactt gacgggtgct cccagatggt gtatagttga accatcattt aacaatgaat 2013841 caaagttaga tgatgacaaa atttttttta gcacatgggt gctacagtac taggaggaat 2013901 taagcaatat gcaaaacggt aaagtaaaat ggttcaacaa cgaaaaagga ttcggcttca 2013961 ttgaagttga aggcggagac gatgtatttg ttcacttcac agctatcgaa ggagatggat 2014021 acaaatcatt agaagaagga caagaagttt cttttgaaat tgtcgaaggt aatcgtggac 2014081 ctcaagcttc taatgttgta aaactctaaa ctcaatacat gatgatgaga tgacaaatag 2014141 aggagaggca ttcgcctctc ctatttgatt ttcatctgga tttcaatcgc caaaatgttt 2014201 tgtttacacc tctgttcaat ctcttcaaca tacttttcca ttgatggttt tccttttttc 2014261 gcgatatcgg ccagttcttc taaatcactg tatatttcta taaatgtttt gtgaaggatc 2014321 aacttcaagt ctttatcatc catagctgcg ttccccttct ctatcaagat acctcaaata 2014381 gtaaaacggt cctatttatt ctggttcaat agttatatcg gcttattttt attttctttt 2014441 ctattttggt acataaattt caaaaaaact ctgcaaaata atggcggagg tgttttttgt 2014501 gacttcagaa tttcataatg aggatcagac cggctttacg gataagcggc agctggaact 2014561 agcggtggaa acagcgcaga aaacaacagg agccgcgacg agaggccaaa gcaaaacatt 2014621 agtcgactct gcataccaag ccattgagga tgctagagaa ctgtcacaat ctgaagagct 2014681 ggcagctctc gatgatcctg aatttgtaaa gcagcaacag cagctgctag atgacagcga 2014741 gcatcagctg gatgaattca aagaataaaa accgcagctt ctgcggtttt tatttttagt 2014801 gattggttaa gacatctccg tattgtttca acttttcacc aaccgtacat ttattgatac 2014861 aaaatgaatg cgcataagtt ttgccaaatt ctttgcgaaa ctgcttctta ataaaacagt 2014921 ccttgcaata ttcatcgtgc agttctgtca gttctttaaa gatcattttc ttatccaata 2014981 tcgtcatctc cgttacggtc taatttcgtg tggctttcta cgaattgatg ggatagaatt 2015041 tttttagcga ggccgtcagc ttcctgattg tcttttcgtt gtattgtttc gtaggttgga 2015101 gtaagcttca gcgattcaag gagtgcttct attttgtcca gccattcatt atgagatgga 2015161 tcataacaag gccagctgcc gtcaagctga ttcagcacaa caagcgagtc ccctttgatt 2015221 gtaattgaat ttctgcttgc cccaagctct cttacttctc ttattgcttc ataaagcgct 2015281 gcgtattcag cttcattatt ggttttcagc cggaagcttt tattttttct caagcgatgc 2015341 cgggttcctc ccaatgaata atagatgacg atcccgagac cggccagttc gctctcttta 2015401 tcgaaactgc cgtcaaaata aacagtaatg tcatcaggct cttgagcaag ctcctctgtc 2015461 agcttttcca attccttcag cgtccagctg ccgcctttct cgtcttcgaa ctctagctcc 2015521 ttcatgtatg gaaaacggcc aagttctctg gcgaacgtac gtgcctgctg tgctgtcagc 2015581 cagtcttcgc taaaaaatga gacggatccc gttccttttg cttctatttt caaatgcggt 2015641 ctgagcttca ttacaatcac cttaccattc attagttgcc gggcttatgc tataatcaaa 2015701 ccaatcttac cccggaaagg aagctttttc atcttgttta ataattcgtt ttggatcttt 2015761 tttgcgatca ttcattttat cattgttctt ttattttata aaggatttgg caaaatggga 2015821 ctgtttgttt ggatcggttt tgcgacagtc tgcgccaacc tccaagtcgt caaaacagtc 2015881 gaactgtttg gcttaacagc gacactcggg aatgtgatgt atggcacaat cttttttgcg 2015941 acagatgtgc tgaatgaaaa atacggacca gctgaagcca gaaaagcggt atggctcgga 2016001 ttctcaacgc tcctgacgct gacatttgtc atgcagggcg tgctgctttt cgaaccggct 2016061 tccagcgaca tatcacaaac agcgctggaa acgatcttcg gattccttcc gcgagttgcg 2016121 ttaggaagtc tgcttgcctt tatcttcagc caaacgctgg atgtttatgt atattcggca 2016181 attagaagga tatttccttc tgatcggctt ttatggctca gaaacggcgg cagtacagca 2016241 gtcagccagt tgtttgatac attcatattc actgcagtcg cctttctcgg catttatccg 2016301 gcagacgtgt ggcttcatat ttttatttct acatatttga ttaagtttgc ggtatcttta 2016361 atttcattgc cttatgccta tgcagccaaa aaaatgatac ctaatgatga aaggagttca 2016421 taatgcctac agaaatatat gtagacggcg caagcgccgg taatccaggg ccttccggta 2016481 tcggcatttt tatcaaacat gagggaaaag cagaatcttt ctctattcca atcggagtgc 2016541 atacaaacca ggaagcggaa tttcttgcat taattgaagg gatgaagcta tgtgcaacgc 2016601 gcgggtatca atcagtttcc tttcgaaccg attcagatat tgtggaacgc gccactgagc 2016661 ttgaaatggt taaaaatata acgtttcaac cgtttgtaga agagatcatc cgattaaaag 2016721 cggcattccc tctttttttc atcaaatgga taccgggcaa gcaaaaccaa aaagccgatc 2016781 ttctggcaaa agaagcgatt cggctgaatg aaaagaatta aatcttgatc attggttcat 2016841 cctaatggcg aggtgaacta acatgaaaaa gaaagataaa ggccggctga ccggcggtgt 2016901 tactccgcaa ggcgacctgg aaggcaatac acataatgac cctaaaacag agcttgagga 2016961 gagagcaaaa aaaagcaata caaaacgcta gagaggatct aaacgatctc tctagcgttc 2017021 agcttttcaa gcatacgctc aattccttta atttggtggc ggcgaagcat gtcagccgcc 2017081 tgctccattt gcaaagtaaa taaagcgtct ttcagtgtgc aggccagcgg cactgagcaa 2017141 tggatttccg caagcttcct cgacatctcc aaatcgctta aaccttgctg aatttttccc 2017201 tgctgtcctt ttggaagaag agaaagattt tccaataaac ggtcaatcgt ttcgtattca 2017261 cgaatcagtt tgtaggctgt tttttctcca atgcctttga ctccgggata gttatcactg 2017321 gaatcaccca taagcgcttt aatatcaatc aaagccttcg gcattacgcc tgtttcttca 2017381 taaaaagtct cttttgtata gactttataa tttccgattc ctttttgaag caaagcaacg 2017441 cttactttat ccgttaacag ctgaagtaaa tctctgtccc ctgttaccac cgtaatgtcc 2017501 gcttcattcg caaataaatc ggcaagagta ccgatacagt catccgcttc atagccggca 2017561 aagccaatat tcatgattcc aagctctgcg gctgcttcct ttgccaaatc aaactgcgga 2017621 atcagctcca caggcggcgc gctgcggttg gccttataat cttggaacaa gtcatttcgg 2017681 tacgttttgc tccccatgtc ccagcagcag acgacgtgtg tcggctggaa tgtttccaca 2017741 gctgtaatca aatgctttaa aaagccgttg acgccgttcg tcggcacccc gctgtcattt 2017801 atcataaagt tgcgatgtac ggccgtggca aaaaaggccc ggaataaaag agccatgccg 2017861 tcaaccagca atagtttatt attattcatc aaataactcc cttttctttc attccttcta 2017921 ttttatcata aagcagccca aaaataaaaa acagtatctc tttaattaga gatactgttt 2017981 gaatatttat caatcgttgt gtcttttgtt gctggcgatc agcttttcag cttcgcgtcc 2018041 tgcgtaagag tcaaaatggg tttgaaatcc gtttttcttt ttggcgttgt tattcgcctg 2018101 tgcatttctg tttccgagct ttgttctgcc caacatgaat ccccccttac gtcggatgca 2018161 tatagtatat gcttccggca ggaggttcac tcgcgacagg atcatccagc ttacatgcgg 2018221 cttacgtatt ctctgaccat ttcttttgat acaagccgtc ttgtcgggac gatgcctttt 2018281 ttagcgagct gattcatttg ctcggtaatt tcattaattg catctgtagt ataaggctca 2018341 tcgtttctgc atttagcaac agcttcttca atcgccaatt cacgcatatt ttcaagacgc 2018401 ataaatgctt tgatatgctc gtgctgtttt gatgaatgtg ctgaaattgc tttatgtacc 2018461 tctgacatta atcgttcatc tcgctttttt ctatttagtc tatcatgact tgaaatacaa 2018521 gccaactgaa ttttacattt ttattgtatt gtctgaattt ttccaggaga tgcacgcctg 2018581 atacgccatt tcaatctctt tcgcatgttc cccttccgca tatcctctta aatatgtctc 2018641 tttttgatcc gttatttgcg cgattgcttt ttcacccata tcttcctgta agcgtctgag 2018701 gtgagcagtg taatgagata tcaggctttc ttcttcattt tttatccatg cctctgtgat 2018761 tttcgtaagt ttcatccgta cagcttcgat aaaggtcgct tttcctttct gctcaaaaaa 2018821 ctgcttcggt gatttgatct cttttagttc ctgctcaaaa gcacgttctt ctatttccgg 2018881 ttcaacttcc ttcaactgta tgccgttcga atgctgatca cccgcataaa cggaaaaata 2018941 accgtcctcg tttaatgttt tttgaaaatg atccagccat tcttcattga tatgccgttc 2019001 gatgaaaccg ctcatgcgaa catcaagcgt tttgatttcc tgaatatatt caaatagata 2019061 ttcatgtaag gctgttgtca tcgctttact gacgttcttt ttccaatccc cgttttgcag 2019121 cccgggatga aatgccgatt ttaataaatc atttgcaaaa tatgataatc gctgtgcaat 2019181 gtgatatagc tgctctcttg tatctttttt tactttttca atgatggttt ttgagttccg 2019241 ccgtttctcg atatcggccg ctgtccgctc aaatgacagc ataaggcact gtttctgcgc 2019301 ttccttctct tctcgggact gatgctggga ttggtgaagc tgaaaaacag tttcgcatag 2019361 tttgtctgcc tccgaactga gctgcgctgc tgacgctttt tttacatcca cttcgataaa 2019421 ccggtctaag tgttttctta ctttcgagaa ctgattataa aatgactccg gttttcccac 2019481 cagttcctcc ttacttgata cggtaaagag ctgcggctca taaacccctt cttttacaag 2019541 ctctgcgctg acataatcgg tcactgtttc gagctctgtt ttatcttttg caaggtctgc 2019601 agcattaata ataaaaaaca ttttatccat gctgagcgat tctttcacaa gtccaagctt 2019661 tcgcaaaaat gaacggtctc cttttgaaaa agagtgctga taataagtca tataaaaaaa 2019721 tgcatcagca tctttgatat attggaatgc cagttctgta tgccgtttat tcatgctgct 2019781 cgcgccgggt gtatcaacga tcgtaatccc tttttcagtg agcgggcatg tatagtagac 2019841 cgttacctct ttcacagcac aggccgttgt ttcctctgct acatacggct ttaattcaga 2019901 gagcggaatc gttaatttct tctgttcctg tatatactgc tgatacttct cgtatgcaag 2019961 caggaaattg ctgatcaatt tcacgtgttc ttcctgcagc ctgttttttt tgactgcctt 2020021 ttcccacttc tctgtgaagg aacggcctgc cggctccttt ggtattccgg tgagctgcaa 2020081 aatttcagcc gttaagtcat cctctgtctt aaacactaca ttcgctgttt tgtttaagtt 2020141 gccattgatt ggctttgtga tcttgttaat tgtcgctgtg gttggcgttg gtgaggatgg 2020201 cagcactctt tcgccgacaa gcgcattggc aaatgatgat ttccccgagc taaagcctcc 2020261 aaaaagagcg agtgtaaatt tccgttcctc aagccttttc accctttcac gaaacgctga 2020321 agtttgcttt aacaacatgc tgcattcgcc taaaatgtca gacaaagtgt aaaagcgttt 2020381 gatttggtct tgaagcggca tttcttgttc cattttgatt tctgatttcg gcatcggctg 2020441 cgccgtcagc tggcttcggc cttgtttctg ctctggagcc gccactcttg ttttcttcga 2020501 tttaaaccat tctgtgtcta tatgcattgg gcatgcggac tcttcttccc aaatggccca 2020561 caggcgatcg gttttctctc gggcattatt ctctaaacgt gcctgttctt gaagaaagac 2020621 aagtttttct gattcttgga cgagccggtc gttaattgtt tgcacatctt tggaaacacg 2020681 ctctttcacc atagcggaga gcacctttat gatgtctgcg gcttctcttt tcgcctcttt 2020741 ccggatgagc tctgccaagt cttttgtata ttgcaataca tattcagagg aaaaggctgc 2020801 accatgcttg accgcgtgtt caatgatgct tatatcaagc ggtgtgcgat aggcctgaat 2020861 cagcttttca ctttcagcgg tatagacatc aaataccttg gcgagtttat gaagcgtgtc 2020921 tatcatatgc caatccgctt cggcctctgt tcgttttgcc acatcagaga aaaaagcatt 2020981 ccgcctttta tctctttcct gtgcagtttt cgctttagaa aagaaaaagc cggttttaaa 2021041 ggaaggctct tgtgattcta aaaatgcagc cgccaattca cgcatttcaa aaggcgtcag 2021101 gttggcgttt tttaaaatac gattgatttc ttcctgcatc ctcttctctg cctcagtcat 2021161 ttgtttttcg gcctcatcca attgatcacg cagcgattgg accagtccag tatggatatt 2021221 aagctgttca gcgaaactcg gagcgcctgt ttcgtctttc ttcagcattt ccgtatgttc 2021281 ctttagcaga ttacggactt tttgttcggt taaagcctgc atattgcttt ttgattgctg 2021341 ttctattctg cttaactctt ctctcagggc ccccatctga ttgaacgggt gatccggttc 2021401 tgttactgat gtaaaataga gcgcttccct tgaaatccct tcattgcaaa gcatctcctc 2021461 tacctgcgct tgatagtctc caaatttcgt ctccgtctca tcatggcggt caatttgatt 2021521 gacgataaaa tacacattcg gaatgctttc ttttattgat ctgagaaact ttacattttc 2021581 ctcagcgtgc acgtgattat agtgaacgac gtaaaacagc gcatccgctt ggtgaagaat 2021641 agaagcagcc gatagaaaat gcgcatcatc tgttgaatct atccctggag tatcaatata 2021701 cgcaaccccg gaatcgatct cagtatacct gtcaaaaatt tcgacgcttt caatctgttc 2021761 cccgtcttta caatattgct gcaccttgtc tttctggtaa gtcccttcca gctcagcaca 2021821 cgctccgtct gttgtatgaa gccgaactcg cttttccccg tttctgatca caacaaggtt 2021881 agcgcttgtc ggaatcgggc ttgtcggcaa aatattctcc attaacaggc agttcagcag 2021941 tgacgatttc cccgctgaat aatgcccggt aaacgcgata taaacctctt catcagccgc 2022001 ttttttcatg accgcagcca gtttagcagc cctttgttca tcttgattct caataaattg 2022061 cttataaagt tccccggttt tatgcaaaag ctcttttctg ttttgatctg tcataagtct 2022121 gaaccccttt gtgccgtttc aattgtgaac ctttttcgaa agatctgaat tcattccctt 2022181 ttcattttac acaagaataa accaaatttc tttaggagaa tagaaaaaag ccgccattac 2022241 ggcagcttct ataaaagaaa atctgcaact tttacaagtt ccagattcat caaacagatt 2022301 tattagagat tccttttaat acaaaaccaa ttaatacact atatgtacaa accgctccaa 2022361 gcaaaaacag cattgtcatt tgcttcacca tcctgattga gaatcttttt caaacccatt 2022421 ttaacatggt tgagaatgat tttcaatcgc tattttacgc tgtattcctg taatgctttg 2022481 tcttctgcgc gaattctgac gcttaacaac acggcattga aaatggaaaa cagacacatg 2022541 gtgacgtatg cttgataaag cagcggaatc agcaaaattt cgaggataac aacggcatag 2022601 tttggatgtt tcatccattt atatggacct ttttttacaa gctctacacc tggaacaaca 2022661 aggattttcg tattccaata tgctcctaag gaacaaagcg cccaataccg tacgatctgt 2022721 acgcttaaaa tcactgcagc gataccgagc caccagctgg acggctgttt attcatcagc 2022781 agcacctcgg caattaagga caggaaaaaa aggatatgca tcgtaatgat atacggatag 2022841 tggctctcgc caaattcaat tgctccttgc ttctttacct tttgttcgtt ttgcctggcc 2022901 actgccattt ctgctgctct ttgaacaatg agaatggcga tcaacaacca aaacatgagt 2022961 caggccccct tttcccagct gaataatagc aactctgatg agaaacccgg ccctaatgcg 2023021 ccaatcagtc ctcgttcagc ttccttttta tgtccgttct gcagatggtc tttgatcaca 2023081 tacaagattg tggctgaaga catatttccg tgcttttgca aaatgctttg cgcagatgaa 2023141 agcttttctg acgacagccc gagacttttg atgtatgcat cgatcacttt ttttccgcct 2023201 ggatgcgcca aaaaaacact gatatcatgg aatgacagct tatgtttgtc caaaaaaatc 2023261 tgtacatttg ttttgagcca tttttccacc aaggtcggaa tgtctcgtga gaaaatgact 2023321 ttgaatcctt gatcggtaaa gtcccagccc atgacatctt ctgattgttt catcaaaaca 2023381 gattgggcgt ccattatctt cggcgcaagc ttcagctttg acaccctgcg gtccgccttc 2023441 tctccgcata ataaagctgc ggcaatgccg tcaccaaaaa gcgaggtgcc gatcagattg 2023501 ctttttgttt tatcttccgg ctggaatgtc aggctgcaca gctcggcaga aatgacaagc 2023561 acaaaagcct caggatacgc tttgcagtat tcggctgcac gcgcaagtcc gctggctcct 2023621 cctgcacagc caagccccca aatcggaatc cgcttcgtat atggagaaaa cggaagttca 2023681 ttcataagcc gcgcctcgat actcggtgtg gaaagacctg tactggagac gaaaaaaaca 2023741 gcttccactt tctcataagg aatggcttct tgaaaaaatt ccggatgaga gaggcactca 2023801 cgaacagccg ctctgctgtg tttaagtgtt tcttctatgt atatttgatt tttttcttca 2023861 aagctgtgcc cctctttata ccattcaatc ggcttaacaa actgtctcga atggatttgc 2023921 ccgtttttaa aggaggataa cagcctgtca atatccttaa aagaatgctg aaacatatag 2023981 cgggcgaact cggccgcttt ctcttggttt acattatacg caggaagact tgttccaatg 2024041 gataaaataa acgccatgcg atcacctctt tgcatacatt gtgccgcaac aatctttttt 2024101 atatgcaaaa aaaactccgc cgcggcggag ttagactgct gttttttgtt cagcgaggtc 2024161 agcttcttgt tctatttttt tagctttaga aaaaacgtta tatacaatat ttaagacgac 2024221 tgcagtaaag ctgcccgcca caatgccatt cgttgtaagc agcgttaagg cactcggaag 2024281 ctgtttgaaa atatccggca caacggtcac accgagcccc aatcccactg agcaagcaac 2024341 aatcagcaga ttttcctgtt tcgcaaaatc aatgcggctg agcattttaa ttccgtaagc 2024401 aatcaccatt ccaaacatcg ccaccattgc accgcccaaa acagcggatg gaataatagt 2024461 cgtgaaagca gcgatctttg gaaacagccc aaatgccatt aggatcacac ctgtgaccac 2024521 aatgacggca ttttttttga tccctgtgag ctgaacaagc ccgacatttt gagagaatgc 2024581 cgtgtaagga aaagcgttaa aaataccgcc cagaagcaca gccagtcctt cagctcgata 2024641 gcctttagac aaatctatct ctgtcaaacg gcggtttgtc aggtcaccta aagcaaagta 2024701 aacaccagtt gactccacaa ggctgacaat tgcaacgatg gacatcgtaa tgataggcgc 2024761 tgcgtgaaaa gacggcgctc cgaagtaaaa tggctgaatc atttgaacaa ctgccgcgtc 2024821 cgaaacatta tcaaattgaa cttttcccat aaaatatgcg atgaaggtgc caatcaaaat 2024881 accgatcaaa atcgagacgg acttgataaa gccttttgta aaacggtata gaagcacaat 2024941 gatactcaac acggtaaaag caagtgcaag attggagaga tctccgaaat ctgcacttcc 2025001 ttctccgccg gccatgttat tcatggcaac cggcatcagt gtaataccga taatcgtaac 2025061 aacagagcct gtcacgaccg gcggaaaaaa cgatacgagc tttccaaaga aaaatgaaat 2025121 aagaatgaca agaatgcctg aagcgataat gctgccgtaa actgttgaaa ccccatattc 2025181 agatccaatc gctatcatcg gcgatacagc tgtaaaggta cagccaagca ctaccggaag 2025241 cccgatccca aaaaatcggt tgctccacac ttgcagaagt gtagccacac cgcacataaa 2025301 aatatcaatc gatactaagt aagtcagctg ctcgacagtc agtcccattg cttttccgac 2025361 aatcagagga acgacaatgg cgccggcata catggcaaga acatgctgaa tccctaaaga 2025421 cagcgttttg ccgaatccat ttctcatgaa tgaacctcct gtacgaagga cacttttcct 2025481 tcttctaaag actgaattct tgccaaagat tccactcggt agcccagttt tacaagttca 2025541 tctcttcccg gctgaaatga cttttcaata acaatgccga ttcccgcaat agaagctccc 2025601 gcttgcttca caatcgacac aagcccgtgc gctgcctgtc catttgccaa aaaatcatcg 2025661 ataatcagca catgatcctg atccgacagg tgggtcccag acactgcgat ttggctttct 2025721 gtttgcttcg taaaggaata aacagacgct gtcagcaagt tgtcggtgag tgttaacgat 2025781 ttatgctttc tcgcgaagac aactggcaca cccagcttca agcccgtcat tacagcggga 2025841 gcgatacctg atgattcgat tgtcacaatt ttggtaatac cgtcttttgc aaacctagac 2025901 gcaaattcat caccaattct ctgcataagc agcggatcaa tttggtgatt caaaaaagaa 2025961 tccactttca atacctgatc agataatacg acgccttctt cctctatttt ccgtttcagt 2026021 gcttccatcc tgtctacctc cgttatgaga ataaaaaaag cattgcccgc tcaaataaag 2026081 agcaagcaat gctgatatca caaaaaaccg tacacgtgcg gttccattgc tcacccatag 2026141 tcggacattt acggtgcccg gtagaaactt gcgtgccata tccacgcgat tatatgagtg 2026201 ttcctattat attgtaataa attatatcaa gattctaatc tcttgcatag gctgaaaata 2026261 aaaattcccg aactttaatt ttgttttttt agatatcatt cgtatttcaa ggggattcga 2026321 tataaaagag tctgacgacc gcgccgccag gcttttgatt ataacagata gagatttgaa 2026381 tatttgtttg ataaataatc aattaaatag cgaacattca gctcttctcc tgttgcatct 2026441 ttaataatgt ctaacggctt tttccgtttt ccgtgaatgt gcaccttttc cgtcagccat 2026501 tgctttatcg gatggaactc tcctctttcc aagagagcgt caaattcagg gagatcctca 2026561 agcatttttt gtttcagctg agccgcatac atgtagccga gcgcatagga tgggaagtag 2026621 ccgaaatctc cacctgccca atggacgtcc tgtaaaatcc cctctgcgtc ggtctgcggt 2026681 gtaatcccta aataatcctg gtatttttga ttccaaagcg acggcagatc ttccacagac 2026741 acttcattgc tgaaaatcgc tttttcaatt tcataacgga tgatgatatg aagaggatac 2026801 gtcaattcat ccgcttcgac cctgataaat gaaggttttg attcattgat tgcccggaca 2026861 aaatcatcca gggagatgtc cttgaactgt acaggtgatg cctcttgaat cttcttatag 2026921 tacggagtcc aaaaatgctt gttgcggccg ataaaattct cgtaaaataa tgattgcgat 2026981 tcatgaattc ccatcgatgc gccgtctgac aagttcgtgc cactgagtgc ttcatcaata 2027041 ttttgctcgt aaatcgcgtg cccgcactca tgaatggtcc caaagatcgc cgtccggaaa 2027101 tctttttcat catatctcgt cgtgacccga acgtctcccc gattcagcgt agttgcaaac 2027161 ggatgaacgg tttcatcaag tcttccgcca tcaaaatcgt agccaagctc ctgtaaaaaa 2027221 tacagactga gctctttttg cttttctttc gggaacgctt ttgtaataaa gcttgtatct 2027281 ggtttatttc cggaagctgt cacctgttta acaagaggga taatcgcttc cttcagctca 2027341 gcaaacaact gatcaagcac ctttaccgtg acgccgggct caaacaaatc aagcaatgca 2027401 tcataaggat gctcttgata tccccaatac gtaataaaac gtttattgaa ttcaatcagc 2027461 tgttctaaat aaggagaaaa caagctgaaa tcagattttc ctttcgcttc ctcccacgct 2027521 gtttctgcct ttgaacacag aatcacgtat tctttgtatt cagcctcagg gattttctta 2027581 ttctcttcat actctttttt cgccagttcc actgcttttt tcgtatcttc cgacaagtca 2027641 tcaaatcgtt catacaggac atcgataagc tccttcattc gatctgatgt ttggatattg 2027701 aatatatctg ttgaaagctg gccgatactt tcggcacgat cctctgagcc atttttcggc 2027761 gcgcctgttc tggagtccca gtgcattaac gcaactgctt cgctgtaatg tgagattctt 2027821 tttaaaagat caaaaaattc tttttcatat gtatgtatct ccatatccat tccctcccta 2027881 ttctagccgt tccattacag gctaatggaa gggggtatga aagtcaaatt gtttgtataa 2027941 aaggctgccg gtatgttttg tggcagcctt tttattcagt tgatcgtcat ttgatttttt 2028001 ggcggaggtg ttctccgctt tttctgcttg atttttttat ctacccacac tgttgccagc 2028061 ggggttaaga gcgaggtgac aataacgctt gtcgcgataa ttgcagttgc cgactcagca 2028121 actggcgcaa atgaggcatt cgcttccgct aatgcatatg gcacggctac agccgcccct 2028181 gccgtagaag aagcggccac tcccgcgaca ccatctcccc gcgcaataaa acgatcaagc 2028241 aaaaacaaag aactgcccga taaaatgacg acagaaactc cgataaaaat gccgagcagc 2028301 cctgattgga tcagcattcc aaaattcaag gtattgccga gcgaaaaggc gaaaaatgga 2028361 atgatcgccg gcacaacctt gctgaataag tctctgagat catgatccag atttccaagt 2028421 atacatccaa gtaaaaacgg gatgactgtc gctgccagcg tttcccatgg gaatgcggca 2028481 agtcccgtca caccaaacgt caccatggtc ataaaaggac cagattctgt actgataaag 2028541 gcgaaagcgc ccgcatcctc ttttcttccc atgtgattca tgagcgccaa atacagtccg 2028601 ccgttcgttt cattcattac cgcgacaatt gctaaaacag aaaggcctgc aaaaaagccg 2028661 gattgtatgc catcgtcagg tataaattgc gctgcgatca cgccgagcag cgccgcaaat 2028721 ccgatcttcc ccaataataa cgtgattcct tttcttgcga tatagcctga agaacgaaaa 2028781 tcaatcgttg ctcctacgca aaagataaaa acacccagta tcggcagcgt tccggtaatc 2028841 aaagcacccg taaaccctcc aaagaactcc gctgttccag gcgcaaacgt gttgagcgcc 2028901 gctccaagaa atagcggaat aatcatcatt ccgccaggta cccgttcaat tgtcgccttg 2028961 attttcatat tgtggattct cccatcctcc ggttatgaaa aaacaattcc acttacactt 2029021 ggaaaacagc ctgcaaatcc tcttttgaac agctgcccaa ctggctgccg actccgacgg 2029081 cgccagctcc ggctctaagc caatcaggca cttcagacgg atgtatcccg cctgtcggaa 2029141 taaaggtcac ctgcgggaaa ggacccgcta aatttttcat aaacggaatg ccaaacacac 2029201 cgcttgggaa cagctttaat gtcgtaaaac cgaatgtcag cgcttccata atttcgctcg 2029261 gagtcaagac gccggggata taatgtgtct ttacaaaaga tagatgttca gcaagatcag 2029321 ctgaaaaacc cggactgaca ataaactgcg cgccagcctt agcagcttcc ccagcttgct 2029381 gcgcgctgat gaccgtaccc gcgccaatta aaatatcttc cctattacgg aaggattcga 2029441 taatatctga tgccccgggg gtcgtatacg tcacttcaac tgcacgaatc cctttatcta 2029501 ataaactctc aatctgctga caggcctcct gcttatcctt tgaacgaatg actgcaatca 2029561 gctttgcttc tttcagacgg ttttcaacga ctttggactc catattaata atcccctttc 2029621 ttttggtgaa ccgttctttg agcagataaa aaagaagcta atttctccct ggtcggcaaa 2029681 ccgtccatat cccccggtgc ctgcacttgc aaagcgccaa tcgcatttcc cctttgcacc 2029741 gcatccttgt acgacaaacc gtctaggata ccgctgatta caccgactgc aaatccgtct 2029801 ccggcgccga ccgtatcaac cacccggtcg acccggcagc cttctagaaa tccttcactt 2029861 gtccccgttt taaagtaagc gccttctttt ccaagtttaa tagcaacaaa gctggcacct 2029921 tttttcaaat aatagtcggc aatgccttca ggtgtttttt ctccggtcaa tagctctccc 2029981 tctgcgatac ccgggaaaaa ccagtctgca agcccagcca gatcattgat tgtgtgtacc 2030041 attgttgctt gatcaggcca aagcgaaggt cttacattag ggtcgaatga aatggtcttc 2030101 cctgcgtttc tcatgtcgtt catgacatga tacgtgaagt ctttcatctc ggctgataaa 2030161 gcaggcggaa tacctgtcac atgcaaatgg cctgcgcatt gaaaataatc tctcggatat 2030221 tcagctgtag ttaatgtgct tgcagctgag tttttcctat agtaggtaac ttgcgggtcg 2030281 ccttctttca cttttgactt cagcagcagc ccggtgggat tttcgtcctg cgagcggatc 2030341 acgcgggaca catccactcc ctctttttta agctcttgta aaataaacgt tccgagctga 2030401 tcattgccga ccttgctcat ccatcccatt cgaaatccga gtctggcaag gccgcaggcg 2030461 acattgcttt ctgctccggc aagcccttta gaaaaagtgg atacttcatg aaggcctcca 2030521 tactcatttg cataaaacat ggccattgat tccccgaatg tcaccgcatc aagcttcatc 2030581 tcttcccaac ctcctcttag ttgagggcac ctaggattaa agtgactttc tcatgatgac 2030641 ttttgcctct aattcaatgg tttgaggcgc tcctttgtca ccttcaatcc tttttaatac 2030701 acgttccatc gccgtcctgc ccatatcatg tgacggctgg gcgatcgttg taatgcctgg 2030761 accgatcagt ttgtaccact ccgtatcatc gaatcctgca atccctatat cttgagggat 2030821 gcgcaggcca agctcttcca tacagctgat gattttcagc ataatcaagc cattcaaagc 2030881 cagaatcgct tttttttgct ccggcatttc cttgtgaaaa gaacgaagct ccgccttaag 2030941 ctgctccttg tcctttacgt caatttcatg caatctgaca agcccgttca cattttgaac 2031001 cgaagccatt tcctgataca cagctgctct ttctgcacga gggctgatag aggaaatcgg 2031061 ttcggtaaac agcgcgacat cagtataccc tttgctgtac accttctgaa gaatctcttt 2031121 tgtgatccat ctgttgtcag tcgttacggt atccagtttc agatccggca gtttccggtc 2031181 aattaagatt gttggaattt gctgttcagc aaaagcgcgg agtacatcct tgttttcccc 2031241 tgttgcgttt aaaatcaagc cctcaaccga atgggcttct agctttaaga gcatttcccg 2031301 ctctttttca ggactgttat ctgtgttgca caccataatg ctgtatccat attgatcaca 2031361 aacctcttcg actcccctga aagcagcgac cgaaaaagga tttgtaatgt cagccacaac 2031421 aaatccgatt aacttgcttt tttttatttt caaaccttgt gccattttac tcggccgata 2031481 attcaattct gcgattgcct ttttaatgtt tttcactttt tcaggagaaa tcgcgtcaat 2031541 ttttccgtta atatagcggg aaactgtcga tttcgaaact cctgcacatt cagctacgtc 2031601 tttgatggtt gtatggcctg ttgttttctt tttcattcaa gtgctcctgt atctcatata 2031661 tttgaaaccg atttcaaaac cgttacaaca aaagaatacc ataattttaa aatttgggaa 2031721 gagttttttt aataatatgt caattcatta ttttttcgtt gactcttttc actatttatc 2031781 ctaaaatttt ctttgaaacc gttaccaaaa tattttcatt caagtgatgc tgaaatccta 2031841 accaaggggg aaatataatg gaaaatcgtt attctgtaca tcctgaacaa gtaaaacgct 2031901 ttacaacaga ggagcttcgc agtcatttct taatggattc tttatttaca gaaaacaaac 2031961 ttacgatgta ttactcacat gaagaccggg ttgtcatcgg cggagcggct ccagggcaaa 2032021 gtgaactgaa gcttgatgca ggtgattttc taaaaacaga cttctttttg gaacggcgtg 2032081 aaatcgggat tattaatgtc ggccagcctg gtgccgttag agtcggcgat gatgaatatg 2032141 tgcttcaaac aaaggatttt ctctatattg gaatgggcaa tcaggatgta tcgttttcaa 2032201 gcctgaacgg ggaaaaagcg aagttttact tcgtctccgc ttgcgcccac aaaagctatc 2032261 cgacacaaaa agccgcccta tctgaactga caccggaccg ccttggtgat gatgcagcgt 2032321 ctaatgtcag aagtctgtac aaagtcattc atcaggatgg cattaaaagc tgtcagctga 2032381 tgatgggaat aacgatgtta gatcaaaaca acaactggaa taccatgcca gcacacgttc 2032441 atgaccgtcg gatggaggct tatctttatc tggatcttga aaaggactca aaggtatttc 2032501 atttcatggg ccagccggac gaaacacgcc atcttgttgt tggaaatgag caggctgtcc 2032561 tttctcccgc ttggtctatt cattctggcg caggaacatc aaactatagc tttgtgtggg 2032621 cgatggctgg agaaaattac acatttacgg acatggatct cattccaatg gatgggctga 2032681 aataagatgg gttatctaca tgacgccttt tcattaaaag gaaaaacagc gctggtgaca 2032741 ggcccgggaa cagggatcgg tcaaggaata gccaaagccc tagccggggc tggcgctgat 2032801 attatcggca catcacatac aagcagtctg tctgaaacac agcagcttgt ggaacaggaa 2032861 ggccggatat ttacatcttt tacattggac atgagcaagc cggaagcgat aaaggattct 2032921 gcagctgagc tgtttgaaaa caggcagatc gacatccttg tcaataatgc cggcattatt 2032981 catcgggaaa aagcggaaga ttttccagaa gagaactggc agcacgtact gaatgtcaat 2033041 ctaaacagcc tgtttattct gacacagctt gctggcaggc acatgctgaa aagaggtcat 2033101 ggaaagatta ttaatattgc ctctctcctg tcttttcaag gcggcatcct cgttccggct 2033161 tacaccgcga gcaaacacgc tgttgccggt ttgacaaaat catttgcaaa tgagtgggca 2033221 gcgtcaggta ttcaggtcaa cgcaatcgcc ccaggctata tttctactgc gaatacaaag 2033281 cctattcggg atgacgaaaa gcgaaatgag gacattttaa agagaattcc tgccggccgc 2033341 tggggccaag cggatgatat cggggggact gcagtctttt tggcatcacg tgcttcagat 2033401 tatgtaaatg gacatatttt agcagttgat ggcggctggc tatcccgctg acaaataaaa 2033461 aagctgacga acgatcgtca gcttttttcc attacatcat gtgcggttca acaggcaaga 2033521 cctttttgac ctcatcaatg atgcgttcat tttctccgcc agcgtaaatg tgaatcgagc 2033581 cgctgtcttg attcgagcga atcaggcgcc cgatgccctg ccgtacacgt aacaacatat 2033641 atggcagatc aacttcttcg aacggatctt ttttcgctcc gttgcgcttc gctgtaaata 2033701 caggatcgtg tggcgggaac ggtaatgacc aaatggtaac attcttcaat gcgtcaccgg 2033761 gaatgtcgag tccttcccat aagtgaactg aacaaagtac tgtttcttct tcctcttgga 2033821 atttctctac taagctgctg atttcctcat caccttcgaa gaaaattgga tacggcagct 2033881 cccatgccgc cgacagctct ttaaactcgt ttaattcttc aaaagaaggg aaaagcacca 2033941 gcgttcttcc tttgtatcgt ttgattgttt caatcgtttc agccgttttt tgttcagcgt 2034001 ccatatctgt ttttgcgtat agattaatac tcatttgctc gtcataatca taaggggaat 2034061 caacagttaa tgacaaataa tcatgaatcc caagactgtc ggcaatataa tcaaacgaac 2034121 cgccttctga cagcgtagca gaagaaaaga tataaggaat tttcttagaa aacacttttt 2034181 cgccaagtac ttctgctacc gttctcggca tcacgacaaa ggttgattct gcttcctttt 2034241 tctccagcca gctgatcgca tccttttgat atagagataa tgaatacgcc atttgttcaa 2034301 catattcttc cactactgac agttcgtatt gatcaatcgt atacatttca gactcaaata 2034361 caagtgcctc accgatttta tcaagtaaac ggcaaagctc gtccgccgcc tttttgacac 2034421 gatggtcatt ttttatttct aaacggtgtg aaccggctac ttcctttgat tcttcagaaa 2034481 gaacatagaa aaattcgtcg tttgcgagaa gcgcatcttc aatcaattct gcaaactctt 2034541 ctctgatgtc attttgcagc aatcgttcta aaaacaattc aagagtagac tgcttcactc 2034601 tataggttag cgctttttgc gcagcaaact ctaacaagtg cccctcatca aatacaactg 2034661 cactatgatc aggcaagagc ggcagctggc cctctcgttt gcgtgattct tccgtccaca 2034721 catgctccat ataaaaatca tgggaacaaa tgattaagtc cgttgacttg cggtagtaat 2034781 ctctggaaag tgtcagaccg catctgtgtc tcatatcaca agtcagacag tcctgaaacg 2034841 agtcgtagct tacgtcagac cactcttcat tcgatagatt tgcgtactgc ttacggtcgc 2034901 catacggata aaagcgctgc atcgcctggg actcgtggac aaatgacggt aacgactcat 2034961 aaagatccag ccatttatca tcatcagaac gctgcattgt tttttcaagc ttcttcaagc 2035021 ataaatattg ctcatgtgat tttgacagcc ttgtatcaat tttcagatca agatgctcag 2035081 ccagcttaga aatatcgccc tcttttttca ccagctgttc aattaatgtt tcatccgcac 2035141 aagcgatgat ggcaggtttg ccgacatacc ttgcatagct gattgcaaaa agaagatata 2035201 ccagcgtttt ccccgttccc actccagctt cggcgaacat gacttttttc tctttaaacg 2035261 cccgctccag ctgaaaagcc ataaatactt gctcgtcccg aagatcaaac cctttttcgg 2035321 gaaggatatc gtaaaacacg tcaccaatcc aattgttcaa ttcttcataa aaattctttg 2035381 ttttcgttaa agaaaaaggc aaacgtgatg ttgtcaccta gttccaaccc ccaactattc 2035441 gacattcaga ccaccaataa tatcattttc cgctgatgaa tacaataaaa aacttggcaa 2035501 tgccaagttt tttgcagttt acttacgatt gatcacatgc gacgataaaa aaggatggtc 2035561 tgttgaataa atatgttcta ccgctttttc taaatcagtt tgcgcatgcg aaatcacaga 2035621 cggagacgaa tcagtcccga gctccttcag ctcgtttgct gttgcgtcaa gcgccctttg 2035681 aataagatta aaatgttcgc tgttcagcat gagatcacct ctgatggaaa taatcatcat 2035741 tgtatgcgaa cttttcattt tatatacatg ctttaccgca tgttatcacc gaaacatgca 2035801 caaactacac ttgatattcc gtctccggat tatccgtctt atcaacaata ttctatcagg 2035861 gagtgatgtt gacatgagtt atagaaaccg attagatcag cattctgaac tgtttcatca 2035921 caattggacg cggcctaaac gttcaaagtc tcaagtaaac ggtcacactg aaatgtccca 2035981 aaccaacatt atattgagaa gcaacgcgaa agctcaccgt tggtaacgat agaatagggc 2036041 tgaaagatga aagaagacgc atgcagagcg tcttcttttt atgcgttttc tgttttcttg 2036101 cgctgcggtc ttacttttga ccagtattga taataatccg ttttaataaa cccgttaaag 2036161 agttttcgtt tcttcgttgc ttttctgcca tatgcttcct caaagttttc atttgatgtc 2036221 agcatataca cagaccaagt atcaagcggc tcgaacgcct gccccatttc tttgtacatc 2036281 tgctcaacgg cttttttctc gccgagacgc tctccatatg gcgggttgcc gacaattacg 2036341 ccaaattcca gatttgtggt aaagtctttg acctgcatct gtttgaactg gattagatct 2036401 cccaatcctg cttcctctgc attttctttt gcgatttgaa ccatgcggtg gtctatgtcg 2036461 ctagcgaaaa ttgtaagcgg ctgatcataa tttgcctttt cttcgacttc aagccgcgct 2036521 ttgttccaca gatctttacc gatccattcc caatcctctg atacaaaatc gcggttgaat 2036581 cccggggcga tgttttggcc gattagcgcc gcttctatcg cgattgttcc ggagccgcag 2036641 aaaggatcaa caaacgggcg gtcaggcgtc caattggtta attgcaccaa agcggcagca 2036701 agtgtttctt taatcggcgc accgccctga tcgacacggt atcctcgttt gtgaaggccc 2036761 gtccctgatg agtccagtgt aatcaaagcc tgatctttca ataaagatat ttccacttta 2036821 tactcagcac ctgtttcttc aatccaatca ttggctttgc cggactgcag cttgagcttt 2036881 tcgacaattg cttttttgac gatccgctga cagtcaggaa cgcttgcaag tgttgatttt 2036941 accgattttc cgatgacagg gaatttcccg ttttcaggta taaatgagcg ccagttaatc 2037001 gctttcgttt tttcaaacag ttcatcaaat gttttcgctt taaaagaagc aacctgaacc 2037061 tttatgcggt cggctgttct aagccaaagg ttcgcacggc agatggcaag tgcatcacct 2037121 tcaaaaataa ctttcccgtt atcaaccttg cattcgtatc ctaaatctcg tacttccttt 2037181 gcgacaacag cttcaatgcc catcggcgcc gttgcaatta gtgtatactt cttcatcgta 2037241 tcaccctgtc ttttaaaact tttctctttt caagataaaa gctctcctta tacgggagag 2037301 cttgttttca tcattttaaa tgtaagtggt ctaacgttct gtaagccatg ttttgttcca 2037361 tcgtactgca aacggctcat cacctcgtac tcaggcggca atcatctatc tacagaaagc 2037421 attctgtcct tctctccgtt gaattccgtt aagaaggttc ccctaccaaa atttgggttt 2037481 ctcgctcgag gggtttaccg cgttccactc tcaccatttc tagtgagact tcgtcactgt 2037541 ggcactttca aggatactca gccatatccg aagacgtagg cttttttcct gccgtcagcc 2037601 tctaaagact gccctagctt atgacttcgc taggcacgaa cactacgggc atctcagcac 2037661 cgtgcgagca tggactttcc tctacagatt caagatctgc agcgattacc cgaacgttaa 2037721 gaacatgaat tattatataa caactgatta caatttacaa gcgccatttt tttcaagcgt 2037781 gatcaatcat aaagcttgct gccaaaaacg tgtttttcta agttagacag ccgttttaaa 2037841 atatcaaagt ttgttgtgtt agattgcaca ggctgttttt tgctggcttc ttcaagctgt 2037901 tttttcagct gcagattttc ctgctgcagt tcttcaattt cttgatggaa ggtttcataa 2037961 tccttaataa tcatatctaa aaatttgtca acgtcttctt gcttgtagcc tctaacgcct 2038021 gttttaaatt ctttttccaa aatttctttc gcagaaagct ttactttatc agcaagcatc 2038081 tttttcacct cgtatcgtga atcatcacat atattttttc agaaatctgt acggttgtca 2038141 aatttctctc tcattgttag tagctgtctt cctccactgt cactctcaag tcatccattg 2038201 taataaagta gatgggatag ccatcctgtt cgcgcctttt ttccgctgtc ccaagcatat 2038261 acttagggga gccttccttt tccgggtcat ataaaagcag aagcccgtcg gacttatcaa 2038321 tgaagaactg atttttttgt ttgaattgaa gcgggctttc ataaggacgg tgagtcaggc 2038381 ttgcttcata gtctgcctga gccagaactg cttcatactg ttctttattc ggttctttcc 2038441 agttcttttc ctgctcgtaa aatggtgtga tgacagctac ctttaagtca gggtattcct 2038501 cctgcaaatc atatgcagct tctgccgccc acagctcaac tccaagctgg cccgaaatta 2038561 aaatccattc taatccttca tccaaaaaag caatcagccg gtttttaatg gcttttttta 2038621 tgtaatacag cgccttgtca tcctgcttaa atatccccag ttcaaacggt ttatagcccg 2038681 ttattgccaa tactttcatc atttcacctg ctttaaaaaa tggggctccc gtgggcccca 2038741 tttgttgtgc tgcattgttt acaccatcaa gctgcacgtt ttccatacta gtagtcgcag 2038801 caaggttttc ctgcttgaaa atgctgatgc gtagccgggt caacatttga gaaagtgtgt 2038861 ggaaagtagt gaacgtgctg aaaatgctgg tggtttacgt ttgttgtatg ctgtgggtga 2038921 atgtgcggca cgatagtctt cgaaaacgta tggtgttcac agcaatgagt aggatggaca 2038981 attggcgcca tcatatgcgg tctgcagtga tgcatgataa aatccccttt ccataaactt 2039041 tattacaata ctaagttatg aaaaataagg ggtacatgtt ctgatgcaaa gacctatttt 2039101 aaaagtgtgc aattaagctg tctttaaagt ttgaaaacac aaaagcaatc aaaaatacca 2039161 caacaaagaa caagtaaaaa acacccttat acataccaac tctcccttta aaaataacta 2039221 acgtcatttt acaggattcg ccgctattct acaacaaaat caatgtgaat tcagcaaaaa 2039281 aaattcatgg cgaaacaagt cgtcttttgc gctttcccgg ggaatattta agaggaatat 2039341 ttcctcttta gccgggcaat tctcacatgc agtttttcag tttctttctc tgataagcat 2039401 gccgcatcgc taagcgattg ctctgctact tgcaatgctt ttccgaattc ttttttctta 2039461 tgctcaaaat atttcgcgag ctctattaca gcagcgtatc tgcacttctg gttttgcgag 2039521 cgggacagct tttcccaaag cggcactgct tcttccaagc ggttttgttt tttgtacagg 2039581 agcgataaat ccagccgtgc actgtcctgg tcctcaaacg atttttctat aagcctttcc 2039641 aactgcttga tcgcttggtc cgtttcttta tgagccataa accatttcgc catagcatag 2039701 gcttcactgt gttcttttgg cgcatgtgat tctgaaagga tttttttaga catatggatg 2039761 tacaatgaaa tgagtgataa cacatccatt tcattatgat gcaggacacc ttttaaaaga 2039821 tccggctctt gcgccttgat aaaatgaaag taaagcattg gcgccaagta gcccggtgtg 2039881 tcttctagcc tgcggatgcc gagctcctct ttttcaaccg tgccaagaga tacacggtcc 2039941 attttgtgtt tccacaggcg tctagctcca tgcaaaagat caaagtggcc aaactccgga 2040001 agcttcggaa gtctgtcacg gatcaaggtg tgccttgttt tcacctgcgg ccaatcaaag 2040061 gctttgccgt tgtaggtcac aagtgatgta atgtcaacct cgcttaaaaa gctttggtac 2040121 aaggcgactt cgttccccgg tttgggcaaa agatgctgtt tgactgtcac tcggtcttca 2040181 tatactctcg catgcccaag caaaaaaatg gtattcccag ctccaccccc aagaccggtt 2040241 gtttctgtat caaagaaaaa gaggttgttt ttgttatacc cttttgctga caatgtatgc 2040301 gacaggccgc tttgattcca cagtgtgatc acttcctcaa gctcagaaaa gctgtataac 2040361 ccatggcggt gagaaagcgg atattctact tctctgatga ggcaatattc atcttcgaag 2040421 atgaaaggct tcatgccaaa agcctcccac tcttctaaaa acgggatgtc atcaaagtgg 2040481 ttttcttgtt tgcctgcttc tattttttgt tctccttcgt cgagcgccat gtgctttttc 2040541 atccgttgga gtttcccttt taatgacata tccggcctcc ctccttacga catttgatcc 2040601 aacagctgca aaattctttc ctttgctttt atcccttcta tttccgtacc tatacaagac 2040661 ggacagccgt catgacaagg acaatgtgta atcagttgtt tcgccgcttc attaatgtct 2040721 gaaaaacgtt taaagacttc ctccgccaaa ccgataccgc ccggataatg atcatataaa 2040781 aatatggttg gcaatccggt atgggctgct ttaatttgag aaacaacatg aacatcattt 2040841 cgatcacaca tgatatacac agggacaata tgctgcagca cattcgagat gccaagaagc 2040901 agctgttcca gtgtcttttc cccgatgtct tcatccgctg ttttgatttc gagccaagct 2040961 gcacttgtat gcagttcttc ttccggcaaa tgaataggtc cagacccaat attttcaaaa 2041021 gtggtcattt ttattttttt aaaaatggtc ggcagggcat tgacagtgac gtctccgtag 2041081 tgcaatgacg tacggctttt ttctttcgtt ttatcgattt ctaatacctt cagctgaact 2041141 gccaggtttg catccgtata atattcgaca tcgacttttc tgacatacgc ctttttatgg 2041201 tcccaatcga gcttctcaac ttgatactga acgccttcat gcaaataaat cgcttcatca 2041261 tgcaaaagcg tcatcgcact aaaacggtcc atttcaccga taatccttac atttgcaata 2041321 tccgactgat caactataac gacattttcc tgggaggcgg aacgcaaact gatgtttgac 2041381 gcagggaacg actcacttgc ccaatggtac cgttcgccgt tgcggtgaag aacagcctct 2041441 tcctgaagat actcaagaat atcactgact tccatggctc caaattcttc atcagctcta 2041501 aaaggaagct cataagccgc acactttaag tggtctacta aaataatcaa attctccgga 2041561 ttgattcttg cagattccgg cgaacgatta aagaaatatt caggatgccg cacaatatat 2041621 tggtcaatcg gtgttgaatt ggctaccatg ataatcaaag attcaccgtg tcttctgccg 2041681 gctcgtcccg cctgctgcca agcacttgca acacttccgg gataccccgt cattacacac 2041741 acttgcagct ggccgatatc aacaccaagc tctaaggcat tcgtactgac cactcctaaa 2041801 atgtcgcctt ctctcagtcc tctttcgatt tctcttcgct ctttcggcag atagcctccc 2041861 cgatagcctc tgattgattt tgttccaatc tcttttttca caagctcctg aatatggctt 2041921 aaaataattt ccacccgaac tctgcttctg gcaaaaacaa tggtctgcac tttgttttta 2041981 aggaactctt tcgccagttc attcacttct gcggttgcgc tccttctaat attcagcggt 2042041 ttgttcacaa ttggcggatt gtaaaacaca aaatgcttgc gtccgctcgg tgcgccgttg 2042101 tcatcgacca gccgcatcgg tttgcctgtc agctgctctc ccaattcctt tgggttggca 2042161 atcgttgcgg aagtacaaat aaaaactgga tcacttccat aaaaccggca gatccgcttc 2042221 agccgccgga tcacatttgc cacatggctg ccgaacacac ctcgatacgt atgaagctca 2042281 tcgatgacga tatacttaag gttttcaaac aaactgaccc atttcgtatg atgcggtaga 2042341 atggcagaat gcagcatatc ggggtttgta atgacaatat gacctgcttt tctcaccttt 2042401 tgtctgattg ccggagacgt atccccgtca tatgtaaagc ttttaatatc aatgcccatt 2042461 tcatcaataa tttcatttag ctcgctcttt tggtcttgtg ccagcgcttt agtcggaaat 2042521 aaatataacg cccggtttgt ttcatcttgg gcgatggact gcaggactgg gaggttgtag 2042581 cataacgttt ttcctgatgc tgttggcgtt acggtaacga tgctctctcc tttttgcaca 2042641 tattgaaaag cggaatattg gtgagtatat agttcatcaa tgcccctttt cgaaagggcc 2042701 gctttgattc tctcgtctat actttcgggc ataggccttg tttttgcttc ccgaggctca 2042761 atttcatgcc aattcacaac gttttcattt ccttttaaat cagaaatgag ttcagtcagt 2042821 gatttctttt tcattcttta cacctctttg tcaagtacag tttaccgaat atttgtttgc 2042881 atggctaggt gcaaatttta tacagttgaa taaaaaaagc aaggcatacg ccctgcttat 2042941 ttcgctttta ttgtaaagag ctttgattcg cctttacgag cagccttttc gcctgccgat 2043001 accattgatc ctacagcctc accattcatt ataacgattg ggatgactgt gctgctcgct 2043061 ttttctttta ttaattccaa atcacatgta atcagcgggt caccgacctt cactttatcc 2043121 ccttctttaa tgtgggcagt aaatccttct ccgttcatat tgactgtctc cagcccgaca 2043181 tgaattaaca gctcaattcc cgagcgagtc cgaatgccaa cggcgtgttt ggtgtggaaa 2043241 atctgaatga cttcaccttc agcgggagaa acgatttcac cgctagaagg ttccaccgct 2043301 attccttctc ccatcatttt ctgtgaaaaa acagggtccg gtacatctga caggtccatt 2043361 actgtaccgt ctgccggaga ataaataacc tcttctgtca ccttttcctg aattttgccc 2043421 attccgaata attttttcag caatgtattt tctcccttct cattcacttc aaccgttatc 2043481 ccttcattca ccactattta accacacttt caattttgct tcaatttata acaacatctg 2043541 gcatagacgc ataatctggt taaaaaaggc ggtggcgata ttggaattcc atgatgacaa 2043601 aaagaacgaa ctgcaaaaga aagaagaaat cataacggag gcaatcgaca ctctttttca 2043661 atcctcagcg ttcggcaacc ttataaacgg atttcagaac ctaatcaact cgagtttaaa 2043721 ggatgtgcag acgaccatac atgtcagaga aagagatact gggctgtata tcgatattac 2043781 cattccggcg acgtttcgag atggcgagat cgtcgttgat gttaaatcga ggtatctcca 2043841 tgtaacactc caagaaaaac agaaacacca aaatgaggct acctttacaa gcatgacaag 2043901 aacggttcag ctgccttatg aagttcgcca agaagatatg gaaacgtctt ggaacgagca 2043961 gacaatgaca cttttctttc caaaaaataa gcatgaatga acgattcatt catgcttcta 2044021 tcatttaaaa aagctggtaa atccctttat taaagatccg acctgattca ttgcactcat 2044081 tacttgacct gtcgtatcca tcattttatt aaaatcaaat tgcccattgg cttttttgaa 2044141 ctgcgacata atgctttgaa attgtgaagg ctgctgttga ttaggccttg ggataggata 2044201 agggttagaa aatacaggcg gctgcatagg cataggctgg atcggagcat aaggctgata 2044261 ataatcctgc tgtccataat gctgctgagg cagttgttgc tctaaataac cgggtgcagc 2044321 ctgctgataa tatccttgca tatgctgagg ataataatag cccatttgcc gaggatagct 2044381 tcgagagctc ccgttcattg cgattccccc ctaaacacaa catatttctc ttctatatat 2044441 gtatgaatga cttctattgt ttgtgtcaca agtgatgatt agcatttgtc aaattgtgtc 2044501 gaaagtttaa attttttaaa aacagaaaaa agtcgaatca ttatggtacc atattttcaa 2044561 tacagatgag aggggatgca ccataatgaa cgtatcatac ttaagcaaac gttttgcaga 2044621 aatgaagaaa tatgaaacag actgtatgaa taaactgatg gactttgcca agttcctcta 2044681 tattcaagga catctcagca taactgagtt tcgtaacagt atgaaggttc tcgaagcaaa 2044741 tggagcagaa agcccggcat atgagatgaa ttaacgtccg gccccctata aaaacgaaaa 2044801 gaagacagcc ttttaccggc tgtcttctct tgcaatttca tcctttactg cgtgcaatgt 2044861 ataaaggact gactcagtga tgtccttgaa tcgtttttta tgaatatgat gaacataaga 2044921 ttgaaggacc aattccagga aattatcctt tacggcctca atttgctctt tatgcacata 2044981 ttttggccgg cggactttta tcaattcaag agcaccctct gcccagcgag cagccagttc 2045041 atcattctct tcaactgcag gctttatcgt ctcaaaaaaa tcataagaat gattactgtt 2045101 ttttccttcc tgataccgat cagcgccttt ttcagcaact tcaatcattt gctcggtcat 2045161 ttccagcaaa gtttgtgata gcaatatctt tcacctcaat gcctatcgta ccaaatttca 2045221 ctcacaaatt cagccgatgc ggtatacctt ctcaaacgca tacctgtgtt caggcgattg 2045281 atacagctca tttatacaaa tatgaagatc tatgatttct tcttcgagca cacttaggcg 2045341 atcgttctcc gtttcccgca tctcagcctc taatgcattt acagaatgat tcaggctttg 2045401 ctcagctcgc gttaattcat cttctatatc agaaagcata cggagaatat ctgtcttgca 2045461 tacataaccg gacattcgtg tacctccctt tccttgtctc tcccggttaa cattctttgc 2045521 tctcaaggct ctttccttcc tcatgacaaa actagaagca aatcgccaaa caaacaggta 2045581 ttccacgaaa agctgaagtt ttcgacaaaa acacccgcaa aaattgtatg atcctcctca 2045641 ttaatgcaaa cgatacttgt gaggaggtgc cgtatgaaaa caagaccgaa aaaagccggc 2045701 cagcaaaaaa agactgaatc aaaggcaatc gattctttag ataaaaaatt aggcggcccg 2045761 aaccgccctt ctacgtaaga agcaaggaat ttccttgctt ctttattttt tcagccactg 2045821 ctccaccgca aaaagcgcat gaagctggcg ctttttatgt aaataccagt ctgtcaattc 2045881 aatctgcttc ggcaattcct cgcgcctaaa gaacgttttc tttatctttc catgaaacca 2045941 atctgttttc gttccgtcta atgagtggat taactcaggg tagcatgtcc ttagcatagg 2046001 agatgttctt tttgtaatcc cgatcatctt ttccatatca aaacgggaac ctgtgtgcgg 2046061 cactgtgtgc aaaaagtgat aaaaagagga gaacaattct ggcttgaaca gcaattgaga 2046121 cagctgcttt cccagcctta tcctttcctc cgcctttgaa aagcgtttca ctgaaatgcc 2046181 gtaaaaaaac ccatttgagg aaggaaaaat aacggtgtta aaatgaaacc agtcacttaa 2046241 ataaaaagga atcgtgtcaa aaacattctt tttaaacgaa ggattttgta taataggtgt 2046301 ttggatagtg ttttgttcat ttataatgag ggcatacatt agccgctccg tatttcgctc 2046361 atgccaaaaa cgggtccatt cttccgacat aaattgtgag acgccaaaca catgcagcag 2046421 atgaaacagc ggtttcccaa ctctttttga ccagtggtat aaaagaagct gcggataggc 2046481 atccgaaaaa ataagccagt tcgctctttc ataggctaaa aagaaccatt tttgctgtct 2046541 ctcacggagt ccaagctgaa acagactgcc ttttaagtca gtcattgacc agccggcatt 2046601 acgagaaacg aaagaagcca aaagcgacca tttgatttcc ggatgacggt cgtaaaatgc 2046661 tttataagca tttgttcttg aaatgttatc cgcgtttttc atttttgtct gccgctcaat 2046721 ccggctcaga agctttctga tggcctgttg ttcttgcacg ttcattcact tccgtcatga 2046781 ttagtttaat aaggaggatg agaaagtgat tcggtatcct aatggaaaaa catttcagcc 2046841 gaaacattcg gtttcatccc aaaacagtca gaaaagggcc ccgtcttaca gtaatcgcgg 2046901 aatgaccctc gaagatgact taaacgaaac gaataagtat tatctgacaa accaaattgc 2046961 cgttatacac aaaaagccga cacctgttca aattgtaaat gtccattatc caaaaagaag 2047021 tgccgcagtg attaaagaag cttactttaa acaatcatcg acaacagact acaatgggat 2047081 ttacaaaggg cggtatattg attttgaggc gaaagaaacg aaaaacaaga cctctttccc 2047141 cctgcagaat tttcatgacc atcaaatcga gcatatgaag caggtaaagg ctcaagacgg 2047201 tatttgtttt gttattatat ccgctttcga ccaggtttat tttttggaag ccgataagct 2047261 gttttatttc tgggacagaa aagaaaaaaa cggcagaaaa tcaattcgaa aagatgagtt 2047321 ggaagaaaca gcttatccga tttctcttgg atacgcaccc agaattgatt atattagtat 2047381 tattgaacag ctttattttt cgccatcatc tggtgcgaaa ggttgattaa cgaaaggttg 2047441 agatgttatg tcagatcaat ttaacagccg tgaagctcga cgaaaagcga acagcaaatc 2047501 gagtccttca ccgaaaaaag gcaagaaacg aaaaaagggc ggattgttta aaaagaccct 2047561 tttcacttta ctcattctgt ttgttttagg cgtagtcggc ggtgctgtta catttgccgt 2047621 catggtttct gatgcgccgt cccttgatga aagcaaattg aagacgcctt attcatcaac 2047681 gatttatgat aaaaatggaa aagagatcgc cgaagtcggc gccgaaaaac ggacctacgt 2047741 ctcgatagat gaaattcccg atgttgtaaa agaagccttt atcgcgacag aagacgctcg 2047801 tttttatgag caccacggga ttgaccctgt ccgtatcggc ggtgcattag ttgccaactt 2047861 taaagacggc ttcggggctg aaggcggaag tacgatcacc cagcaggtcg tcaaaaactc 2047921 ccttctttca catcagaaga cgttgaaacg gaaggtgcag gaagtatggc tttcgattca 2047981 gctggagcgc aattactcta aagatgaaat tttagaaatg tatttaaacc ggatttattt 2048041 ttctcctaga gcatacggaa tcggaaaagc ggcggaagaa tttttcggcg ttactgattt 2048101 aagcaaattg actgtcgaac aggctgcgac gcttgcagga atgccgcaga gcccaacagc 2048161 gtacaacccg gtcaaaaacc cggataaagc ggaaaaacga cggaacatcg tactcagtct 2048221 gatgaaaaag caaggattta tttctgattc tcaatataac aaagcgaaaa aagtggcagt 2048281 gaaagacgaa ggcgtcgtgt cacagaagga atatgaaaaa gcaagtacaa acaaatacag 2048341 cgcatttgtt gaagaggtta tgaaggaaat tgatgaaaaa tctgatgtcg atccatctgc 2048401 tgacggatta aagatctata cgacattaga tacaaaagca caagataaac tagatgaatt 2048461 aatggacgga gacaccgtcg gatttactga aggcatgcag ggcggtgtga cgcttctcga 2048521 taccaaaaac ggagaagtcc gagcgattgg tgcgggacgc aatcagcctg tcggaggctt 2048581 taactatgct actcaaacta aggcacagcc tggttcgacc ataaaaccga ttttggacta 2048641 cggaccagtt attgaaaata agaaatggtc cacatacgaa caaattgatg actcagctta 2048701 tacgtattct aacggaaaac cgattcgtga ttgggaccgc aaatatctag ggcctatctc 2048761 aatgcgttac gctctggccc aatcaagaaa tatacctgct ttaaaagcat tccaggcagt 2048821 cggtaaagat actgctgtag actttgcaaa tggactcggg cttggtttaa caaaagataa 2048881 tgtaacagag gcctattcta ttggcggttt cggtgggaac gatggtgttt ctcctctgac 2048941 aatggcaggt gcatacagcg cgtttggaaa taacggaacg tataatgaac cgcattttgt 2049001 aaaatctatc gaatttaacg atggcacgaa gcttgactta acaccaaaat caaaatcagc 2049061 catgagtgat tatactgcgt ttatgattac agatatgctg aaaacagctg tgaagacagg 2049121 tactggacag cttgcacaag tacctggtgt agaagttgca ggaaaaacag gaacgactaa 2049181 ctttgatgat aatgaagtca aaaggtacaa tatcgctagc ggtggcgccc gagattcttg 2049241 gttcgttggc tacacaccgc aatatacagc tgccgtctgg acgggaatgg gagaaaacga 2049301 ggctggaaag aaatcacttt cagctgaaga gcaaaaagtt gcaaagcgca tcttcgccca 2049361 gctcatcgcc gatgtcgatg acggaagcgg atcatttgag aagcctgaca gcgtagtgga 2049421 agccaccgta gaaaaaggtt ctaatccggc aaaactggca gggccaaata cgccaagcga 2049481 taagaagctc acagagtact ttgttaaagg cacagctcct tctactgttt ctaaaacata 2049541 tgagaaagaa gaaaaagagg aaacagctaa actgtctggt ttaaacgtga aatacgataa 2049601 agacaatcaa tctttaacgt taagctggaa ttacgacgga gatgcgacct ttgctgttaa 2049661 gcaatctgtt gacggcggca gctactcgga aattcaaaac agctctgcaa aagaggcagt 2049721 tatttcgggt gtgcagccag gatctgtata caaattcgaa gtaacagccg tcagtgatga 2049781 tggcaaaagt acagcttcca catcttatga ggtgccaaaa gctgaagacg atgaagataa 2049841 aaaagaccag caacaaacgg atgatgaaaa acaagatgat gagaagactc aggatgatac 2049901 acaaactgat gattctcaaa aagatgacgg tcagacggat caagatcaga cagatgattc 2049961 aacaaacgat caagacaaaa aacaagacaa tacgaacacc aatccgtccg acaacaataa 2050021 ccaagaccaa tcaaacgata atgataacga caacagtaac aaccaggata cgtcggatgg 2050081 tgattcgaac tctggtaaga atgattcaac aggttctgac acgaataaaa ataaaacaga 2050141 cacatctaat aaaacacaaa caaactcatc atccattgaa aaaacaaatt aaacaaaaaa 2050201 gccgtcacct ttggggtgat ggcttttttg gtacacaata aaaaacctcc cgttttaaca 2050261 ggaggtttta tcgattcatc gcatgatatt tataaaaatg ctttttcatt tcggtaatca 2050321 gctcatcaag ctgaataaag caatggtatt gggtcggctt aagaagaata aattccactc 2050381 gttcagccca attaatcggc tttgcgggat atgatttctc cctcagttct tgccaatcga 2050441 gcgatttcac cggctcacct gctgtccaat gtaacgaagc cagcaaacac acaatgccct 2050501 ttaacatttc gttttggtca catctcgatt ttcgtgtttg aaagactggg agaagtgatg 2050561 ctttgatgtc atcccacact tcaaataaaa gcggaacgta tttcccgctg tcctcccatg 2050621 gcaaatcgcc ttgtaattcc gtgcagaaat caaaatacac gggattggtc tgcaaggttt 2050681 tcttcatatc cgaggaactc ttctggccaa gactgcgcaa gtattgctca taggaagcca 2050741 acacttcttt tgcttgcgtc atcgtttcac cagtcctttt ttatccctct tctgcccttc 2050801 tctgcacaaa gaaagcagcg gacactccgc acagcgcgga gattgggctt tacagtgata 2050861 tctgccgaag aaaataagcc ggtgatgcgt aacggaccaa tcttctttgg gaaccttgcg 2050921 catcagcgtc ttttcaactt ccagaaccga gtccttccac cggcaaatgc ccaatcgttt 2050981 gctgactctc tccacatggg tatctacggc tatggccggc acgccaaacg caacggatac 2051041 cactacgttt gcggtctttc tcccgacccc tggcagtttg acaagctcat cgcggtctct 2051101 cggcacttct ccgccgtaat cttcaataat cattttactc agcttttgaa tatttttcgc 2051161 tttattacga tataaaccga ttgatttaat atcctgctga agctcttcca gcggaacagc 2051221 caaatagtct tccggccgtt tatatttttg gaataatgtt ttggtcactc tgtttacaag 2051281 tgcatctgta cattgcgcag ataaagcaac agccaccact aattcaaaag gattggaatg 2051341 aaccagttca cactccgcat gaggaaacat gtcacctatc ttgtctaaac agaattcaat 2051401 ttgttttaga tttaacacga ttgtcacctt ttcactttat tgttcaagcc aattgtaaaa 2051461 aggaacctgc cttttatact ctttttgcgg ttcattctgc tttgcttgta cacgccggaa 2051521 tttttggctg tgtatttttg cctgctccac agttttaagc ccatttttct tccattcaaa 2051581 caaaatccgg tcaatgtagc ggaaactgag ttttcctgat agtacagcct cttttaacgc 2051641 gtgtttgatc agttgtgcgt catgctgatc ctggtcctgc cagatcgcca gcgtttcaca 2051701 ctccaaaggc gataacggtc ttgcgaactc ttcctcaaaa atggtataaa ggcttttttg 2051761 ttccccttct gcttttcttt cctgtgtttg attctgtgca agctgaatat actcgtacag 2051821 cttgccccat aaaggctgaa gagaatattt ctcaaatttg atgccgtttt gatcctcgca 2051881 ttcttcaata aacagaaagc ctttttgaat aaacatccgc aatctgtttg tacattcttc 2051941 aacagaaatt gacatacctt cctgcagctg attcggtgta ggaaaatatg atcctttttc 2052001 taaatgcatt ttaattttta acagcagaat aagttctgtt tcattaagcc caagctgttt 2052061 ataatgcgtg agcagaagat tggggatggt tgatgttccc tgctcctgca tatcaataaa 2052121 ttgctgtttt ttcatcgtca cacctcttac tgtaaaggat tgtgattgcc cctttactgt 2052181 aaaaagtctc ccttgcagga gactcttttt tgtttcattt gaatgtatta cggatacaga 2052241 cggtttaaca gtcttgggaa cggaatcgtt tcacgaacgt gaggcgctcc gctgatccaa 2052301 gctactgtcc gctctaatcc aaggccgaag ccggaatgag gaactgatcc atattttcta 2052361 agttcagcat accatttata agcgtcagaa tccagtccat gttctttaag acgcgattcc 2052421 aaaagttcca tatcgtgaat ccgttcagac ccgccgatga tttctccata gccttccggc 2052481 gcaatcaagt cagcgcaaag cacaacgtcc tcacggtcag aagccggctg catatagaac 2052541 ggttttaagg acgtcggata gcgagtgatg aataccggtt tgtcataatg ttcagcaatc 2052601 gctgtttcat gaggcgctcc gaaatcatct ccccactcga tatcgtcaaa gcctttttct 2052661 ttcagaaatt caatcgcttc atcatacgta attcttggga acggggcttt gatttgctca 2052721 agttttgacg tgtctcttcc caatgtgttt agttcaattt tgcaattttt aagaactgat 2052781 tgcacgatga aagaaacgta attttcctgt acttgaaggt tttcttcaaa ttctacaaac 2052841 gccatttccg gttcgatcat ccagaattcg attaagtgac gctttgtttt agacttttcc 2052901 gctctgaatg tcggtccgaa agagaatact tttcctaaag ccattgccgc agcttccatg 2052961 tagagctgtc cgctttgaga cagatatgca tcttcatcaa agtactttgt cgcaaagagt 2053021 tctgttgttc cttcaggtgc gcttccagtc aaaatcggcg gatccacttt tacgaagcct 2053081 tcgttattaa agaattcgta agtcgcgcga atgatttcat tacggatttt catgatcgca 2053141 tgctggcgct ttgaacgcag ccataaatgt ctgtgatcca tcaaaaattc cgttccgtgt 2053201 tcttttggtg taattggata atcggtcgct tcgtgaatga cttcaatatc tgtcacagca 2053261 agttcatatc caagcggaga acgctcgtcc tctttgacaa tcccttttat atagagcgac 2053321 gtttcctgcg tcactgattt agctgtttgg aaaatgcttt cttccacttc cgcttttact 2053381 acgacaccct gaataaaacc ggtaccgtcc cgaagctgta aaaacgcaat tttcccgctt 2053441 gaacgcttat tagcgaccca agctccgatc gttacttcct cacctacgtg cttgtacact 2053501 tggttgattg ttgttttcaa catatttccc tccaaaacaa gaaagacatt cggaagctca 2053561 ttgccccgcg aactctttta tcatcacttt attatacccg ctcttaacta accgggtcaa 2053621 tgcagataaa aagcggcttt tctgtcagcc gctttttgat ctgttagcta tgtttttcta 2053681 caaaacgctt gattctttca atggcttctt caagaagatc taacgatgtt gcataagaaa 2053741 gacggacatt ctcaggagag ccaaatccgg atcctggaac aatcgcaact ttttcctcct 2053801 cgagaagcgc tttaacaaat tcatctacat ctttgaaacc gcaagattga gctgcctctt 2053861 ttgcatttgg gaacaagtaa aaagcacctt ccggcttcac gcagctgaac cctgggattt 2053921 ctatgagctt tgcatagatc gtatttaatc tatgttcaaa tgcttctctc atttcttcca 2053981 atggctcaga aggcccgtta taagcagcaa tcgctccgta ttgtgcgatt gatgtcgggt 2054041 ttgacgtgct gtggcttgca aggttcgtca tcgctttaat aatgtcttca gagcctgccg 2054101 cataaccgat tctccagcct gtcatgctgt gggacttcga tacgccgttt ataatgaccg 2054161 tttgctcttt cagtctgtct gacagctgtg caatggaaac atgtttcttt ccgccgtatg 2054221 taagtttttc ataaatttca tctgacacaa tcaagatatc atgttcaagg cacacttcac 2054281 cgagcgcaga tagttcttct tccgtataca tgacaccagt cgggttgctt ggagagttaa 2054341 taacgattgc ttttgttttt tccgtaattg catttttcag ctgctcaggc gaaattttga 2054401 agtgattttc ctcaagccct tctacataaa caggctttcc gccagcgagt ttcacctgct 2054461 ccgggtagct tacccagtaa ggcgttggaa taataacttc atcttcttca tccaaaatca 2054521 cttggaaaag ggtatacaga gcatgtttgg caccagtgca gacaataatt tgagacggtt 2054581 tgtattcaat attctggtcg cgtttaaatt tctctgcaat gctgtttttc agttcagcca 2054641 aaccaccgga aggcgtgtat ttcgtatggc cctcgttcat cgaacgcaca gcggcatcaa 2054701 taatatgctg cggtgtattg aagtcaggct cgcctgctcc taagccgatg acatcatggc 2054761 ctgcggcttt cagttctttc gctttcgctg tgattgccag tgtggttgat ggtgttaatg 2054821 cggatactct ttttgccagt ttcaacttga actcccccta attcgtctta aggcgtgata 2054881 tttttgagaa tctttccagt tgtaaagtcc acataactta aactgtattg cccttctttg 2054941 tctaagtacg tcacttccca aagcaggacg tttccttctc ttgccagatg aacctctttt 2055001 tgctttgaaa ccagcccttc atcctttatg attttcgccg ctttgtcttc agagattccc 2055061 tctttcgctt cttttgagag aatttttgct tttttatcag caggaaccca gacatataat 2055121 gcagtgcctt ttttatccgt tccctttaca acataatatt tttcttttcc gacaaatgtt 2055181 tcgacttgat caacatgggc gagatcggtt tcttttttag cttcagcagc tgctgcttcg 2055241 tgcccctctt ccttttgtgc catggctgat ttataaatgc ttgccgagac aagaagtact 2055301 gctaaaaaaa taataccaaa aatgacggta aatattaatg ctttttttct catcttctca 2055361 cctacgtacg ataaatggta aaaacggctt ggtttttgtt ttcttcatcc agcgcaaggc 2055421 cgaacatcag attgtctctt ttcagtgtac gattcaatgt gtccacaatt ttatacagat 2055481 catcagaatg ctctacatta attgttgaaa gaatttcgat tttactttcc attttttcat 2055541 cctccagttt gaacaaatat tgttagtcat actccatttc aggacacgcc atactagtat 2055601 cacagagcgg gaaatccgct tttaaataaa acaccatcct actcccacac cgcaaaagcc 2055661 gctttatgcg gcttttattc tttttcccct gcaacataag cttcaagctc gctgtcagtc 2055721 atttcggata ctgaggttgt cggcaaggca tcaagaaaca gccggccgta accagcggtt 2055781 ttaatccgtc tgtccaatat aataatcgtt cccttgtctc ccgcagaacg cagcaagcgt 2055841 ccgattcctt gcctgaaggt cagcacagct tccggtaatg acactgtttg aaacggattc 2055901 tttccttttt tgcgggcaag ctcacatttt gcagcatgaa gcgggtgatc aggggaccgg 2055961 aatgggagcc tcacgatcat tactgtcgtc agctcatcac cagggaaatc aacgccttcc 2056021 caaaaatgat ttgttccgag caggatcgcc tgattggatg ttttaaaagt cttcatcagt 2056081 ttgccgggac ttccgcctgt aatcccttgt gccaagagct gaatgccgga agcactcatg 2056141 ttatgcttaa gctcctggtg aacctttttc agcatatcat gggatgtaaa cagcacaagg 2056201 attttaggct gtttttcctt tgccatcagt tcgatataac gggctgtatc ctgtataaat 2056261 tcaggttgcc ctgtatcctg aattgatttc atttcttttg gaatcatcac ctgcatacgc 2056321 tcatcgtaag aaaagggtga ctcaattctc attgtccgcg ggaaaaagtc actcagtccc 2056381 agtcgttcaa tcataaattg aaaagaacct tcgactgtaa gagttgcaga tgtcagcacc 2056441 acactatttt tgcgcgcgaa aaactgatca gccagaagtt caccaggttc aagaggctgt 2056501 gcgtaaatgg ccactgcatt tttcgcaccc tttgcatcta tttcaatcca aaccgcttca 2056561 tcgtcatcag agccaaagaa gagcttctgc aacgtctgac agtaatgctg caagcctttc 2056621 atgcttcttt ggtattcatc ggctaaaaag acggttttgc tcttcatgcc cttcaaatgt 2056681 ttttccataa gggatgactg cgcctcaaaa agctgctgca aatgtgtcag catggaacaa 2056741 agcctctccg caccatctgt taagatcgac cagcttttat cctggctttc tttgttcacc 2056801 ttaaacacta gacggtttaa gtcttcttta ggttttcttc gtttgacaaa agaatgtaca 2056861 gagctaaaga aagcatcact ttctgcttga acgtgctgaa gccactcttc caattcgaaa 2056921 aatgaatcaa ccggcaggct gtttcgctgg aatagctgtc tcatcttttt tagaagtccc 2056981 tgctccttca gagtgccgat tctgctcaat ttcgtatgca attctatgta cgtggctctt 2057041 ttccctaaat gttcgcttgc cgcacgttca aaatggtgtg cttcatcaat aataaatgtg 2057101 ccgctttcgg gaagcctttt tttatggctg ccttcatcgg tcagcaaaag agaatgattg 2057161 gtgatcacca aatcggaacg catagcaatc tgtttggccc gctcgtaaaa accgatcaca 2057221 tgctcactgc gacttctttt ataggagtca tcgtcataag ccaatctgtc ccacagcaat 2057281 tttccgcctg aaggcaaatt cagttccgct acatctcctg tatttgtctc tgtcagccaa 2057341 acaagaagct gtgcctttgt cagtacggca tcataattat catcttcttc atgaagcacc 2057401 tgctcaaatt tatacaggca taaataatgc gattgccctt ttaaaatcgc cgctgttacc 2057461 ggaaatggaa acagatcttg gacaatcggc aaatcctttg tgagaatctg ctgctgtaaa 2057521 agcgtcgaat acgtgctgat tatgaccggc ttttttgatt tcttggcaaa aagcgcagcc 2057581 ggaataagat agccaatcgt ttttccgatg cctggaggag cttcaatcag cgcatgctca 2057641 cgattggcaa acgcatcagc cacctctctc atcatcatca tttggccgtc tcttttttca 2057701 tacccaggca ttaactctga cagcgctttt tcatttcccg cttcccagct ttcgatctca 2057761 aatgagaagt tctcgtcctc atttatacga acatcgatag cttcaggttc tctgacagaa 2057821 aacgaagaaa agcgcgtata gcccggtatc tcggtatgtc tgttttcatt aatgaacata 2057881 tccaacaaat gcgtcagatc actgatgaaa tgctgcgaaa gccttcttaa ctgctttaat 2057941 gtcggataag gaagctgccg cagcttttca aggatttcca aaaaaataag ccctgtcact 2058001 tcagcatcgc tgtcagcccg gtgcggctga tcatgccgca gctgaagctc ctcgcttaat 2058061 tccgtcagct tatacccttc aaatcccgga aaaacaatgc gtgagagctc gacagtatca 2058121 agcacttcac aatctgggag ctgaaagccc gccttatgta gctcatactt gacaaatcca 2058181 aggtcaaaat ggatattgtg ggcgacaaaa taagcgccgt caagcaattg gaatacttct 2058241 tcagcaactg cttcaaatgg ctgttcattc tcgaccattt gattagagat tccagtaagc 2058301 tgctcaataa aagcagggat tgatttattt ggattaatgt attttgaaaa ccgctcagta 2058361 atttgtccat tttcgattac aaccgctgcg atttgtatga ttttatcgcc tttcttcggc 2058421 gaattccctg ttgtctctac atctataaca acgaaccgtt gcttattcat taaaatggac 2058481 acctcaattc ttgcatacga caaaagtgta acacgttttg tacggaaatg gagcggcaaa 2058541 accgttttac tctcaaaatc ttaaaagaaa acccccgata aagggggctt ttcttctaca 2058601 aaattgtacg ggctggttcg ttccccagca tttgttcaat tttgttttga tcattcagaa 2058661 cagccacttt cggctcatgg cttgccgctt cttgatcaga catcattttg taggaaataa 2058721 taatgacctt atctccttcc tgcacaaggc gtgcggctgc accgtttaag catatgacgc 2058781 cgcttccccg tttaccagga ataatatacg tttcaagacg tgctccatta ttattattca 2058841 caatttgtac tttttcatta ggaagcattc ccacagcatc aatgagatct tcatcaattg 2058901 taatgcttcc cacatagttc aggtttgctt ccgtaacagt tgccctgtga agtttgccgc 2058961 tcatcattgt tcgatacata ttatattctc tccatttctc gaatatcaat aatgatatta 2059021 tctattaaac gcgcttttga aaaagcaact gcaacagcga gaatcatctt tccagcaatt 2059081 tcattcacag gctcgagttc cggataggaa taaagctcta catagtctat ggttccgcta 2059141 gtcgtttcaa tgatatcttt tgcagctttt atcaccgctt caggatctct ttcaccggct 2059201 tggacaagtt ccgcacttgt ttgaagggcc cgatacagct taggcgcttc ttttctttcc 2059261 tcagctgtta agtatacatt gcgagagctt ttggctaagc cgtcttcctc tctgaccgta 2059321 tcgacaggaa ccaattcaat atccatgaag aagtcgctga ttaacccatc aacaacagct 2059381 acctgctgcg catcttttaa accgaaatag gcacgagtcg gcttgactag attgaaaagc 2059441 ttcgtcagta cgatcgcgac cccgtcaaaa tgtccttctc ttgagcgccc gcataacacg 2059501 tctgtgcgtc tttctacatg aatcgtgaca ttcttttcac cgggatacat atcatgagca 2059561 tctggcgtaa aaagaatatc gactccggcg ttttctgcaa gagctgcatc ccgctcaata 2059621 tcgcgcggat atgcttcaaa atcttcatta gggccgaatt gtgcaggatt cacaaaaata 2059681 ctcataataa cggcgtcgtt ttcttgtctt gctttgtctg ctaaggttaa atgcccctca 2059741 tgcagaaacc ccatcgtcgg aacaaatccg attgacttgc cctctgaatg gtattgtttt 2059801 atggcttctt tcagctgtga aatatcagta atctgtctca tcttattttc ccccgtacaa 2059861 gccgtcaagc actgtctggt tcatttgaaa ggaatgcttt tgttcaggga aagcacgatg 2059921 tcttacatcc tgaacatatc cgctgattgc tgtttcgatg gtttcatcaa tgcgcgtata 2059981 ttgctttaca aatttaggtg ttctctcaac accgtggccg ataatatcat gataaacgag 2060041 aacttgtccg tccgctttca caccagcccc gattccaatg accggtatgc ttagcgtctc 2060101 ggcaattttg gctgtgagtt ctgccggcac acattccagc acaagcatca tagctcctgc 2060161 ttcttcgcat tttatactgt cttctattaa ttttttggcg ctttgttcgt ctttgccctg 2060221 tactttatag ccgcccagta cgccgactga ctgcggtgtc aaacctaagt gactgactac 2060281 tggaatgcct ccaagcgtca atgcgcgaat ggattcaaac acgccttctc cgccctcaag 2060341 cttcagtgcg tcagctccgc tttcctgaac gatagccgct gcatttttca gcgtatcttc 2060401 cttagacagg tgataagaca taaacggcat atctgtcaca ataaaggtat tcggcgcacc 2060461 ccttttaacg gcttttgtat gatggatcat gtccgcaact gtcacaccga cagttgaatc 2060521 aaggccgagg acgaccattc caagtgaatc accgactaaa atcatgtcaa ctcccgcttg 2060581 ttcagcaagt ttagctgccg gataatcata agcggtcagc atgacaatcg gttcttcaga 2060641 ctccttcatt tttagaaaat ccagttttgt tttcatgttt tctcctcctc atgtttagag 2060701 gagatgatct gccgttttct tctgcaagcc aaaaaacctt ccgttacaac gagaaggatt 2060761 cttcactttc taaagttcgg cgagtttcat ccctctgtcc cagtcctttt ttggatcaag 2060821 gcagactgct gcaatgtcta tctattttaa taataggtgc agttcgcagg cgatactgcc 2060881 caatggaagt ataccaaaat caacgggctt gtaccaacac attagcccaa ttcgatatcg 2060941 gcagaataga tttttttaat gccttcgttc gtttctaaaa gcagaacgcc ttcatcatct 2061001 atacctaacg ccttaccgta aaaggttccg tttaacgttc tggctctcat attagtgcca 2061061 ataccgagcg catagctttc ccataaaagc ttaatcggcg taaatccgtg cgtcatataa 2061121 tcccggtacc gtttctcaaa gcatagtaaa atatgctgga tgacgccggc ccgatcaatt 2061181 ttttccccag cagcttggct gaggcttgtc gcgatgtcct tcaattcatc tggaaaatca 2061241 ttaggctgct ggttaacgtt aatgccgatc ccaatgatca ctgaacgtac gcggtcttct 2061301 tcagcctgca tttccgttag gataccgact gttttttttc cgttaatcaa aatatcattt 2061361 ggccatttaa tatccgtttg gatgcctgct gcctcttcta ttccctgcac aacagctact 2061421 gcagcaagca gagtcagctg cggtgttttt tggagcggaa tgtcaggccg caaaatcagg 2061481 ctcatccaaa caccgtttcc ttcttgagaa tgccataccc tagacattcg gccccttccg 2061541 gctgtttgtt tgtcagccac cacaagggtg ccttccggtg cgttattatt cgcgagctca 2061601 tgagccgttt tttgcgtgct tgaaagaacg tcatggtaaa taagatgctg gcccatcact 2061661 tccgttttta atccaaaacg aatttcgctt tcactgagtt ttccgggttt tttgatgagc 2061721 cgatatcctt ttcttctaac ggcttctact tcataaccct ctttccgaag ctcttcaata 2061781 tgcttccaca cagcagttct tgaacagccg agagcatcac tgattttttg gccggaaata 2061841 aattcattgc cggcctgaga aaataattca ataaggtctt ttcttaatgt tgaccgcatg 2061901 tcttcagcca ctcctctatg tgtttctttt gattggagag cttccctgtc acaacagcct 2061961 gctcgatcca ctgtaattct tctgacaccc attttccggc cggccggttt cgaagcgcaa 2062021 gcaagtcctt acccgtgata tcaagatcct taaggctttt gatcggcagg ttttgataag 2062081 cgtactgaat gtccttcagt ttcttttcat ccagtttttc gttttgccga agctgcgata 2062141 ttttggccgc tgagagcagt gcttttttcc cagctctgta cattgtcatt gcgtcaaggc 2062201 tctggccaaa cgtatcggca atgtgaatgg cttccttgat cacttttccc gggagcttcc 2062261 aggctttcag gaaaaggggc gcgtctttca aaactatgcc aaggttaatt aaaagagcag 2062321 cccaaagctc ctcacgggat gttaaagaga agaatggaaa ctcactcgtt gaaatcaggt 2062381 tttctcgttt atgataaaaa ccaggaagct cttcatacaa tctcgtttga atgagtgttt 2062441 gaagcgcctg gcgagaagct cttccctgca gcaatttctc aaactctata gtttttcgtt 2062501 cgactgaaac atgggagagg agtgattttt ctttcgcaat ggcttcttct gtttccggtg 2062561 aaagcgtaaa gccaagctgg ctcataaagc gtacggctct cagcatacga agcgcatcct 2062621 cttgaaatct atcctcaggc tttccaacgg ttcgaatcac tttctgatca atatctttct 2062681 tgccgccaaa ataatcaagc accttcccgt ccgctgtcat ggccatcgca ttgatcgtta 2062741 aatctctgcg ttttagatcc tcttctaatg atgagataaa ttgcacttct gacggtcttc 2062801 tgaaatcaac ataatcagat tcagtccgga atgtcgtgac ttcataggtt tcatcctccc 2062861 agagcacaat aatggtcccg tgctctttgc ctacatcaac agtccgctga aacagccgtt 2062921 ctacttgatc aggtgccgca tctgtcgcga tatcgacatc tccgatcgtt cgtttcatat 2062981 agctgtcacg aactgcgccc ccgacaaaat aagcctgatg gcccgcttcg attaagatgc 2063041 ggagcacggg aagtgctttg ataaaaactt tttccatgtg atcactccgg ttctgctaaa 2063101 tcggcataaa tctgttcata ctggctgaca atttttttag aagaaaattc attttcaagc 2063161 atctctattg ccgcctttgt aaaacgattg cttagctgtt catcttctaa aatgctcatc 2063221 gcgcgggctg ttgcggccgt aacatcaccg acatccacca aaaatccgct cacattgttt 2063281 tttataacct cagggatacc gccaatgttt gttccaatac aaggcactcc gcaagccatc 2063341 gcttcaagca ggacaaggcc aaagctttct ttttcagata gcagcagctt caaatcgcta 2063401 atagaataaa gatcttcaac acggtcttga tttccaagca ttaagacttg gtcttccaag 2063461 ccatattttc tgataagctc gcaggctgtc gatttctccg gaccgtctcc gactaaaagc 2063521 agcttcgctt tcgttttgcc agcgatattg cggaacacac ggatgacatc ctgcacgcgt 2063581 ttaacttttc tgaagttgga cacatggatg acgacttttt catctggtaa aattccatgt 2063641 ttctctttaa ttgccgctgt gtttttcttc agatacacgc gctcgtctat aaagttataa 2063701 atcgtttcaa tttttttctc cggtttaatt aaatcgtatg tttcagccgc aagcgctgag 2063761 gagacggccg tcaccctgtc tgatgactca atagcaaaac ggatcagatc ttttagagac 2063821 ggatcataac ctaacaccgt gatatccgtg ccatgcaaag tggtaacaat gccgatattg 2063881 cgtttcagca tttgttttgc aagataggcg caaacggcat gcgggagagc atagtgagca 2063941 tggataatgt ctaaattctc ccgttccgcc acctcagcga ttttgcttgc caatgtcaaa 2064001 tcatacggag gatacttaaa aacagcatat tgattaacct caacttcatg aaaatgaata 2064061 ttgggatgat atgtattcag tctaaacgga atgcttgatg tgatgaaatg gatttcatgt 2064121 cccttttcag caagctgctt ccccagttct gtcgcaatga tacctgagcc tccaacgctc 2064181 ggatagcatg tgattcctat ttttagtttt ctcattgttc gcccccaagc acatcatgat 2064241 caagcatcag catccgtttg gaaaagaaac cttcggcata ctccacgccc gcttctttac 2064301 cgtaaagctt ttctctcgct tcaacgattt caatataccc attcgtcaga ggagtagaaa 2064361 cggaatcctt tgacgggata aactggcttt tgtaggcgtt gaggctttgt ttctttgcct 2064421 ctattgtatc cgagatatca ataacaaaat ccggctgatg aaaaccattt atcatataat 2064481 agtaaacctt gctgacttta tgcgccggaa ggcttttttc gtctttatat ttatggattc 2064541 cggcggaaaa gatcgcttct tccaccagtg cagccgcatt gccgtgatcc ggatggcgat 2064601 cctttttata cggcataaaa accgcttttg gccgacagat tctgatgaca gtgacaattg 2064661 accgaattgc ctgatcactc attattaggc cgcggtctgg aagcgttagc tgaattcttt 2064721 tatctgcgcc taatatgcgg gctgcttcag ctgcttcttc tttacgcaaa ctgaccgtac 2064781 cgttagaaga gagttccgct tctgtcaaat cgcatatcat tacttttttt tcctgtttga 2064841 caaacttcgc tattgtgccg cccattccga tctcgacatc atcactgtgg gcgccaaaag 2064901 caagaacgtc agcattatac attcggctct tctccccgaa gaaggtcacg gaattcgaaa 2064961 acaccttcat caagtgtgcg cacaagaatt tccgcagtac ccatatttgt ggcgagcgga 2065021 atggaataca catcacataa acggattaat gccgagacat ccggttcatg cggctgcgcg 2065081 gtcagcgggt cgcgcaaaaa aatgacaaga tcgagtgcat tggcagcgat cagtgcaccg 2065141 atttgctggt ctccccctaa agggccggat tgaaaacgtt caatttgaag acctgtcgcc 2065201 tcatgaattt tcaaccctgt ggttccggtt gcgtatagat catgattctt taaaatatcc 2065261 cgataggcag tcgtaaattg aaccatatcc tgttttttct tgtcatgcgc gatcaaagca 2065321 attttcattg tttatccccc cgtctaatca atgatatttt ctaaaccata cacaagctga 2065381 tcaatcttca tgacttgttc gactgacagt ttaacgcctg acatgaaaga agcacggtta 2065441 taagaatcat ggcgtatctg aagcgtttgg ccatccatgc cgaacatgac ctcctgatgc 2065501 gcgatcagtc ccggaagacg gacgctgtgc aagcgaatac cgttttgctc cgctcctctt 2065561 gctcctggga gaatttcttt ttcatccgga tgtccttgct gcttttcttt acggacttct 2065621 gaaatcattt ccgctgtttt aagcgcagtt ccgcttggtg cgtcaagctt ctggtcatga 2065681 tgaagctcaa taatctcaac atcctcaaaa tagttggcag ccatttttga aaatttcatc 2065741 atcagtatcg caccgagcgc aaaatttggc gcgatgatgg ctccgatccc tttttcttct 2065801 gttaaagatg tgagctcttt taaatcagct tctgagaaac cggttgttcc gacaactgga 2065861 cggactccgt gctctaatgc aatttttgta tgtacttttc cgatttcggg cgttgttaaa 2065921 tcaatcaaga catccggttg tgtttctgta aaacaggcat ggatatctgt gtaaatgaaa 2065981 gcatctgact caacaggcat cacatcagat aatttttgct gatcgtatgt atggtctatg 2066041 gcccctacaa ggtcaaaatg tggtgttcgt tctgccaatt taacagcttc ctgccccatt 2066101 cttccacgcg gtcccgcaat gactaattta attgtttcgt ttgacatctt gatctcctct 2066161 actttccttc ttcttttctg gtccagcgat ctttatctct tgtattaaat ttatgcatga 2066221 ctcggtcgtg agcttcctct aaagagatat caagagagtt ggctaaacaa accaatacaa 2066281 atagcacatc gcctatttcc tcttccatgc ttttatcatc ttcagtcgct ttttttggtt 2066341 tttctccata acggtgattc acttctctgg caagctcgcc cagttcttca gtcagcctcg 2066401 ccatcatggc cagcgggcta aaatatcctt ctttaaattg gcctatgtaa cggtctactt 2066461 cagcctgtat gtctttcatt gttttatcac tcactgaacg aaacctccta tcatcctctt 2066521 acatgttagc taattcagat acgtttgaca aatgtttaag cacgtttgct gttttctttt 2066581 tcatccacta taatataaac gctatctaat ggaaggaaaa ggggttttgt gtgatgcttg 2066641 gagaaattag attaaaaaac atatttttta ttttaatcgg agcggcaatt ttttcatttg 2066701 gcttggttca tttcaatatg cagaacaatc tggctgaggg cggttttaca ggtattacac 2066761 ttttgcttta tgcccttttc cacatcagcc cctctatatc gaacctggtg ttgaacattc 2066821 cgattttttt tattggctgg cgtttgctcg gcaggacaat gtttgtttat acccttgtcg 2066881 gcactgtagc cttgtctttg ttcctcagca tctttcagcg atatgaaatc catatgcccc 2066941 ttcagcacga cttagcgctc gccgctttat ttgccggcgt attcatcgga gccggactgg 2067001 gtattatttt taagttcggc ggtacgacag gcggtgttga tatcatcgca cgtttagtga 2067061 ataagtattt tgggattccg atgggcagaa cgatgtttgc tttcgatgcc tgcgtcatca 2067121 ttttgtcttt gcttacttat ctctcctata aagaagcgat gtatacgctg gtagctgtat 2067181 ttgtagcggc aagattaatc gattttattc aggaaggcgg atacgctgct aaaggcgcta 2067241 cgatcatctc ttcgaaaaac gacctgattc agaaaaagat tcttgaagaa atggaacggg 2067301 gcgtcaccat tttgaaagga caaggttcct acacaaaaga ggatatagat gtactttatt 2067361 gtgtggtgcc gaaaaatgaa ttggtgatgc tgaaaagcgt gattaactcc attgatcccc 2067421 atgcctttgt agcggtaagc gatgttcacg atgtgctcgg agaaggattt acgcttgatg 2067481 aaaataaaaa tccgcttccg cgctgacatg taatagaaaa aaggcggctg accgccgccc 2067541 ctcatcctta tttagggtag tccctttttt tcagcttgtt tttttccgcc ttgtactttc 2067601 tgtaaccgac ataggtaaga gcagtaatga tgatactgcc ggttgtaatg atcacccaga 2067661 gtaaagacgg atcggcatca tcctcctcca ccctgtcaaa cacatttttc aggtcatgct 2067721 gaagaaggga aagccgttca agcttcgtgc tctctgtcat ttgctgaaat tcctcttgct 2067781 caataacatc tatatgtttt ccgactgttt caagctgatc ctctgataca tcgattgtaa 2067841 gactggggta aatcaagtca tataaactga taaattcatt ccatttttca tgaaagcttg 2067901 tgcttccatt cttttggaca tctcgcttca gttcagtaaa agcttccata atcggttttt 2067961 ccagtgagcc ccaaagcggg tcagaccgat tgtcaaccgc atccatcagc attctgaact 2068021 gcgcggctgc tctgagtttt tgtgtgtctg atgtatcagc ttgctttaaa ctccgaacca 2068081 tatcattata gcccaatgtg atttgacgaa tttgggctcc cgttagcatg gggtcttgct 2068141 gttttttctc agcggatttt aatgtttttt caaaatactc caagacttga agcgcctctt 2068201 catatttcgc ctgtcgggtc atttgaaaga ctgtatcgga taaatcattc aattcctcga 2068261 ggcttccccg ctctgcagcc ttggcatttc cattataaaa aataagtgca atcaacaaac 2068321 agatcgtcag ctttcgtttc atgcaggtcc ctcccactct ctctccttac agaatatgaa 2068381 gaaagggaca aggatagacc aacattgtct ttacatcagc tcaagcttcg tttgcttttt 2068441 tgagaccaca agaaagtaag caagcgcgat tgaaaagata cttagccaaa atgttccgta 2068501 tcctatttca gtcatataat cagaaagcat agagtattgc ggcatcatat caaacaagta 2068561 gtcaatgaca tcgttatgca gtgtccagac tgcagcaatt gcaagatgcc aaaatgaaaa 2068621 acgaaaatac ggactgtata atacgccttg aactgccatt gcaaaatgcg aagcaattag 2068681 catgtagccc tcccacggca agtcaccagt tactgcaagc acaagaaaat tcatagccac 2068741 cgcccatagg ccatacttta cgagggtaac tagcgcaagc gcctctaaaa gcggagcatt 2068801 ccgtttcatg agaaaggcaa gcagcacaaa cagaaagaaa aacgttgctg tcggactgtc 2068861 cggaacaaaa atcaggaaac gggccggtgt ctccaaaagc tgcggcaagt accaatagta 2068921 gccgtaaacc gttcccagaa aattaatggc taagacaaga ataagcatcg gccgctgccc 2068981 taatacatat tgaaaccatt tcacatcgaa tcaactctca gtctgtaaaa ataatatgtc 2069041 catataaaaa agctgacgcc gggtcagctt ttgataataa aagtatatcc ttccatttga 2069101 caattcacaa tacgttattt tgcggttgtt tcagaaataa attttgcaag ttcttcgagc 2069161 tgcttatcat ttcctttgaa cacacccgcc ggcattttgc ctttcccttc tacagcgatt 2069221 tttttgattt catccggttt cagcccgctg tcaaccaatg aaggcccggc cgctcctccc 2069281 tgaaggttat ccccatggca agaaatacag ccctgttcct taaaaacctt atatccttct 2069341 gcattggtgt caatgtcggc ttcttttgta attttcccct gttcttctgc cttggcccag 2069401 tcatgagtag caactgactg ccacgtcaaa aatacagcag cggaaatggc cagaagcatc 2069461 ataccgacag cgaccggacg cttccacggc cttctttctg tccctctgtc taggaatgga 2069521 gccaaaagca gggccccaaa agcgagacct ggcataatca tggcgccgac cactgtaaag 2069581 cttccggcgg cgtattcata cttcaacagc tggtataaga aaagaaaata ccaatccggc 2069641 agcggaatat aaccagtatc agtcgggtcc gccatccgct ctaaaggcgg ctgatgcaca 2069701 atcgtcaaaa cgagaaaacc gatgagaaag acagctccaa ccatccattc ctttaacaag 2069761 aaatttggcc agaaagcctc tgttttaccc ggatactccg aataatcctt cggtatattc 2069821 ggcttttttt cagccggtat ccttgagtcg cctacaaatt tcatcccttt gccccggtgc 2069881 atgtcatccc ctccctttta ttcgcagatc aagagtttaa agcggtcctg aaatcccctg 2069941 cttccggatc ataataaaat gtgcagccat cagcccgaac aatgcggcag gaagaaaaaa 2070001 tacatggatc gcaaaaaacc tagtcagcgt ttgggcgcct acaatatccg gatgccctgc 2070061 aaggagcgtt ttaacttgcg ttccgatcaa aggcgtggct tcggcgatct gcagtccgac 2070121 ttttgttgca aacagagcct tcatatccca aggaagcaag tagcctgtaa agccaagacc 2070181 gagcataaca aaaaagatca gcacaccgac aatccagttc agctcgcgcg gttttttata 2070241 cgcgccttgg aaaaagaccc tcagcgtatg taaaaacatc atcacaatga ccaggctcgc 2070301 accccagtgg tgcatccccc tgacaatctg gccgaatgcc acttcatttt gcaaataata 2070361 taccgattcc caggcatttt tgatatcagg cacataatac atcgttaaaa acattccaga 2070421 taatacttgg ataacggtta caaaaaacgt cagtccccca aagcaataca caaacgcaga 2070481 gaaatgatgg gcgggattca catgttccgg tacttcgtga tcggcaatat ccctccacat 2070541 cggtgtaata tcaagccgct cgtctaccca gtcataaatt ttgttcagca tgtcaccctt 2070601 cccccttagg ctttgctttt ccaagataca ggaagccgtc ttttacttct tgctcataat 2070661 gatcaagagg cgcaagcggc ggcgtgccag ggacattggt gccgtccttt tcatagagtc 2070721 cgtaatggca tggacaaaag aatttattcg ggtttttagg atcactattc cagttcaccg 2070781 tacaccctaa atgcttacaa attggcgaaa gtgctacaat ttcatccccg tttttgaaga 2070841 cccaggctga tcttgactct tctgactcat accaggcatc gacttgatta attttaaaat 2070901 caaagcgctg cggctctttt gtcaactcat caacgctgac aacctgaacc atatcctgct 2070961 tccctgtcga ttttaatacc gggtcgagtg cgaagcgaac cataggcatg agcatactag 2071021 ccgccataaa acctcctacg cctgtgagcg tataattcaa aaattgacgt ctggatatat 2071081 catgttttcc gcccatctct tctcccccct ctaagtcacc cctgcaaact gactaaaata 2071141 gaaaatattg caataactct agacaccctc ataatatatg aatctctcag caaggtcaat 2071201 atagccaaaa tattgtttat aaggaaatgt aagtgttttt ataaagtgct ccataactgt 2071261 aacaaaacgt tcaaaatttc agcagtgcgt tcatccaata tttttctttt taaagagtca 2071321 tttaaatgct ctaatggaac agacgatgta acaatcattt tgcctaacgc atcctcagct 2071381 ctccaacttt cgtcagatgt gagcaggaca acatgcggaa attccgttat cagctcttcc 2071441 cgcaaatcct taagcccttg aacggttatt tcatttctat caacatatgt ataaggcgga 2071501 agtaaatata cccgtccctt taactgcctt tcaagttctt ctgagagaag ctgcgtaaac 2071561 tcgcctttct ccgccgccat tttaaaatgg ttattaaccc ttatgttaat taatggtatg 2071621 acagcggtat caatgtaatc cttagcttgt aaatagtcct tggcatcagt gattctccac 2071681 ctcatcgttc tcccccttta cggcaacaag ccttgcaatt cactgcaagg ctggtcatat 2071741 tatgtgagct gatttaattg gcgcgataat tgttcaaatg cctctttatc atgacgatct 2071801 aacgcgtcgt caatgtcttt taataatttt tctctttgga atgtggaaat agcgtgctct 2071861 aaaatctgtt ccgccaatcc ctgatctttt ttattctcaa aaaggttttt cggaatatgc 2071921 gggttggact ccagcaccgc cgcatattca ggtgagctgt aagccgaacg gaaattaagc 2071981 tggataaaca aatcctgctg tttatttaat ctaatatcat gaaaagattt ttccgcgtcg 2072041 gtagtcatga cattctcttt atagaaccgg aacggaactt cttcaacaca atgtgttgac 2072101 attataatgc ctctcgggca aaattcagcc tgctccacaa aatgaacctt ctccatgaga 2072161 gaatcatggc tcattaagta gttcaagatc caaacgcact ctcggcgctt taactgataa 2072221 tggtttaaaa accaacggat aaaatctttt ttctcattga cagaaacagg ggtctgcatg 2072281 taattccctc ctctatcgtt cgtataatct atatacttat atgttccaca tgaatggtta 2072341 atattcctgc ttatctagaa aattcatcct cgattcgcaa aatcgtttct tcaagctctt 2072401 cattggctcc gtccatttca agaacctttt tcaaaagcgg cagcgcttct ttttgaagac 2072461 cttcttctaa taggaagctt gcgtattcat ataagaaatc tctatcctcc cggtaatgaa 2072521 gataggcagc ctcaaaggat tgttttgctt cctcgtattg ctctaattca gtatatgcgc 2072581 ttgcaagata ccaattgtat ttaggatctt cttcaccgta gcttcgaacc tcttgaataa 2072641 gatcaatgat ctgatcataa tcctcttctt tgtgatacac ggcaagaagt gtatgaagcg 2072701 cctcgacaaa gcccggatca agcgcaagcg cctcctgaag cagcttcttc ccctcttctg 2072761 acttcccgat tttcaaggcc attttggcgg cataaaggaa aagttctttg ttatattcat 2072821 catatctgat cccctctttt gccgttttta atgcctcttc atacattcct tcagcttcat 2072881 agcttttcga gagcggcata taaagtgaag tataagatgg atcaagctcc tttaaatcag 2072941 acagctgctt aatagctgtt ttcacaagcc ccgcctgtaa ggctgtaaaa ccatagccga 2073001 aaatcgtatt aggatcagga ttctcatcga cagctttctc ataccatgga atggcatcct 2073061 caaattcacc tgaggcactt aacgattctg ccagtctttg atggacatta acgcccccga 2073121 tctcactctg ctcctcagcc gttgttttaa aatattgaac cgcttttgca taggctccct 2073181 gagcaaagta aagttctccc agtgcaaaat caataacagg ttcattgtcc agaatggact 2073241 ttgcctggaa aagcttttgt tcactgactt cgaataaccc ctgcatctga taaagatccg 2073301 ccataagcag caaactttcc ggatatgatg gatctgtttc cggaatagtc tccagcacag 2073361 cgagggcttt ttcttcttcg tcaatatcta ttaaaagttc agcgtagaaa ttcgtcagtt 2073421 ctgtttcatt tggatataaa tcatgtagat cactaatcag tgaaatggct ttttctacat 2073481 cgccccactc gtaataaagc tgggctgcaa tggctttatc ttcatcatgc agctgttttt 2073541 cagccttcga gagcgtgttg aggccttttt ctgtttcacc tgcttcaact aattttatgg 2073601 cttcttgaat caatgtattc aaatcggacc ggtcctttct tttcctatac aacatcaacc 2073661 atacaaaaaa agctttattt gttcgggtta atcttatcat aattcagacg aatgcccccg 2073721 gcaaataaga tgcttctgta cggaagggaa ttattgagtc ttattagttt accaaaagat 2073781 cttgagatag aaaatgaaaa aaggaagatc gccctctgta cagtaaagca gctctttgac 2073841 ctgccggctt gtaagtaaag cacatccccc cttttcgttt ttctatccgt tctataagac 2073901 aagctatgtt ttttcgcctc gaattatgat ctgcataaaa aatcctgaag taaaacttca 2073961 ggattttttc gaaagcttat ttaaatgctc gaagaaggtt ggataagaaa cgtgaatggc 2074021 atccgtgtgc tcgatttcaa tcggctcctc cgttatacag gaagcaatac caagcatcat 2074081 tccgattcga tgatctccgt ggctggacac tgcagcgccg cctttcaacg tttgtttgcc 2074141 ataaaccttc attccatctg ctgtcggttc aatttcagca cccagcttgc gaagctcaga 2074201 aacaacagta tcaatacggt ttgtttcttt cacttttagc tctgccgcgt ccttaataac 2074261 ggtggttcct tccgcctgag tcgcaagaag cgcgatgata gggatctcat caattaaacg 2074321 cggaatgata tctcctccga tttcaactgc ctttagagat gacgtttcta taatcaaatc 2074381 tccataaggc tctgcaccgc tatcagcaga tggtttgatt tcaagttttg cccccatgtt 2074441 ttgaaggaca tcaataatac ctgtccgagt cggatttaaa cctacgtttt tcaatacaat 2074501 tctgctgttt ggaaccatcg cgccagcagc aaggaaaaac gcggctgaag aaatgtctcc 2074561 aggaacaaaa atatcagcag ctgtcagttt ctggccacca gcaatggaaa cactcgtttg 2074621 atcttcagaa agcttaacgc caaaagcaga aagcatccgc tcagtgtggt cccgagattt 2074681 atggggctct gttacagttg ttgtgccctc agcctgtaat ccggccagca aaacagcaga 2074741 tttaatttgc gcgcttgcaa caggtgatac ataatcaatt ccttttaatg aagcgccgct 2074801 cactgacagc ggtgtaaact ctccgccggc tctgccgtcg attttagccc ccattttttt 2074861 caaaggctca gtcacacgct tcattgggcg tttcgcaatg ctctcatctc cggctaccgc 2074921 gctgtaaaaa ggacggcccg ccaatattcc gagcatcagg cgaatcgttg tacctgaatt 2074981 tccgacatct aaaaggcttt ctggctcttt cagggcatcg attccttttc cgtgaatcac 2075041 gacatcgctg ctgctttgct caatgtgaac acccattttt ctaaagcaat cgatcgtgct 2075101 cagacaatct gctcccggca gaaagttttt aactgttgtt gtgcctgccg ctagcgcgcc 2075161 aaacataaca gagcggtgag aaatggattt atcaccggga atatgtattt ctccatgtaa 2075221 ggtctgcacc ttatctcgtt tcattttttc cacctcaatc agcataaaaa gtttcatatt 2075281 ccgcccgggc ttcaatgcat tgttctgccc ttttgcggtc gtcatcagac tgaaaactga 2075341 tccttaaaat cccgttaata tcctctcgtg tttcgataat gcggatattc gtgatactga 2075401 tgcgctccgc agctaagatc gctgttatct cggatattac acccggatga tcgggtacat 2075461 ccacatataa atcataaaat gcaggtatcg ctcccttctg ccgaagcggc agcccgtcgc 2075521 gataatcctt ggctgtttta aaataacgaa atagattttc cgcatcttct tgttctacat 2075581 atgtacggat cttgtcaatt tcacgaatcc actcatcaaa acggtctaag attttatctt 2075641 tattatgtaa taaaatatcc cgccacattg ccgggctgct tgatgcaatc cttgtaatat 2075701 ctctgaaccc gccggcagca aaacgcttaa caagcggata caggttttcc gaatgatggg 2075761 tttggtgaac aaggctagct gctacaatat gcggaaaatg actgattacg cttgtaacgc 2075821 catcatgctc ctctggcgac atttccacaa aatgggcatt cgtccccttc agcaggtttt 2075881 ttaactgttc cacagcttgt ttgtccgttt tctggcctgg cgttaaaata taaaatgcat 2075941 tttcaaacag gaactccttc gcagcggcca ctcctgattt atgtgaaccc gccatcggat 2076001 gccctccgac aaattgatag cggctaggca gcacttgatc agcgtaatca accacttttt 2076061 gctttgtgct tcctacatcc gtaatcaaaa gctcatgttc aattcctgaa tgagccagct 2076121 cttcaagcat aaccagtgtt tgttcaacag gtgtcgcaat gattactgta gctgcctctt 2076181 tcacaccgct aataaacgaa tcagcacgat cgtctatcac gcctaatttt aatgccgcta 2076241 ccgcctgttc atcagagatg tcgattccga taatccgttt gccgggatga ttttttttga 2076301 tggctagggc aatcgaaccg cctatcaatc cgagaccggc gagcaatatt gtatctttca 2076361 tttgattcat acgtcatcac ctggtttata gactaaagag gtgatatttg atcacctctt 2076421 ataaaatttc agctaaaatg gcaagtattt cttcattttg ctcttttgtt ccgatcgtaa 2076481 tccggagtga tgtcgggaaa cctaatgcgt ttcctgaccg gacgatatag cctttttcca 2076541 gcagagcctg aaacagttca tcagcaggac gtttaaagtc aattaacaca aaatttgtct 2076601 gtgaagggta gcactttaaa ccatgagttt tcgcaaaatc ataatactgc tgaaggcctg 2076661 cattattttg ctcgacacag gaagcaataa acgcttgatc atcaagtgct gcaatcgccg 2076721 cagcctggcc cagacggctg gtattaaacg gctctctcgc cggctcaatc tggcgaatca 2076781 ggttctcgtc agcaattccg tatccgactc tgagcgctgc cagaccgtat gcctttgaaa 2076841 atgtgcgcaa aatcatcaaa ttggaatact tgcttaagag cggcacggtt tccgggtaat 2076901 cctctgctgt tacatattca taatatgctt cgtcaagaac gacaaggaca cgagaaggaa 2076961 cgcgctccag aaatgcgagt aattctcctt cagatgtata agtgccagtc ggattattcg 2077021 ggctgcatat ccaaacgact tgtgtctgtt cgtcgatggc ttctaacatg gcgtctaaat 2077081 catgtgagcc gtcgggacga agtgcaattt cacgtacttc agcaccttca ataaccgcat 2077141 tatgtttata ttgcggaaaa gtgggggcag cagtaaccgt gtttgtttta tcgtttaaaa 2077201 atgcccggca gatgatctgt atgatttcat cagaaccgtt gccgaaaata agtgatgttt 2077261 cgctgacatt gaggtgctta ctgagccttg tccgcaaagc ggcgctatac ccgtccgggt 2077321 aaagggctag ctgttgaatc tcatgatgaa gcgcctcttt tgcagcctct gaacagccgt 2077381 aaggattctc gtttgaagca agcttcacaa ctttatccaa gccatattct gatttcactg 2077441 cttcaatcgg ctttccaggc tgataaggct tcagctgttt taaatgttct ttgatacgca 2077501 aatcagtcac ctcattttaa actgtacaag ccgctaaacg ccattgcata atcctcaaac 2077561 tcctgcagcg cctgatttct cgtttcagcg ctgatgagcc ggtcctttaa ttcttctatt 2077621 tttctgacga gcgcacttcc cactacgaca ccgtcactaa tttcattcat ctttatgacc 2077681 tgttcacggt ttgatatacc gaaccctaca gcaaccggaa cagtgctgag attcttcaca 2077741 gtacgaatga acgggtacac ggatgaattg aactcattgc ggacaccggt cacacccaga 2077801 gaagatacac agtagacgaa cccctcggct tgttcaataa tggttttcaa acggctttcg 2077861 cttgtcggcg caactaaaga aatatacgtc acctcatggc ttttacattc ctcttgaagg 2077921 ctgttgcttt cttctaatgg cagatccgga acaagcagac cgtcaatatg attttcccgc 2077981 agtaaagcga aaaagtattc tttgttcaat tgtaacacag gattataata cgtaaagagg 2078041 ataatcggaa tattcactcc gttttttttc atttctccgc ctaattcgat tgcctttacg 2078101 atattcattc cttgatcaag cgcccgcttt gaagcccgct ggatcaccgg accgtctgca 2078161 agcgggtcag agtatgcaac accaagctcc aatgctgtgg cgcctgcttt ttggagtgac 2078221 ttcgccagtt caatcgaaac ctcaggaact ggatcgcccg ccgtaataaa cgggataaac 2078281 aatttttctg atggttgaag atccaattta aacatgggct ttcacctctt cttccaatac 2078341 attcattaat gtgttgacat ccttgtctcc ccggcctgat aaacagacga gaatgagttg 2078401 accgcgatcc attcctttgg cgagtttgaa tgctttcgct aacgcatggg cagattcgat 2078461 tgccggcaaa atcccctctt tttctgacaa aagctttaat gcatccaccg cttcttcatc 2078521 ggttatactg tcataagtga cacggccgct tttatgcaaa tatgcatgct ccggaccgat 2078581 tccaggatag tcgagaccgg ctgaaataga gtagggctca ataatttgcc cgaactcatc 2078641 ctgaatgaga taagtcaatg aaccgtgaat aacccctacg gttcctttcg aaatagtggc 2078701 ggcatgaaga ggtgtatcaa ttccttttcc tgctgcttca gcgccgatca gttcaacatc 2078761 ttcatttaaa aatgcctgaa acatacccat cgcattgctt cctccgccta cacatgccac 2078821 tactttatca ggcatagtgc cttcaatacg tttcaactga tccttcgctt cctctccgat 2078881 cattttttga aattcacgga ccacttgcgg ataaggatgc gggccgacaa ctgatccaat 2078941 catataaaag tgatcctcac aatgctgaac ccagtaccgg atcgcctcat ttgtggcatc 2079001 cttcaatgtt ccgtttccgc ttgttacagg cactacctcc gctccaagaa gcttcatgcg 2079061 gaaaacgttc agagactggc gggcaacatc ctcttcaccc ataaacacag tacaggaaaa 2079121 gccgaatttg gctgcaactg ttgcagcggc aacaccatgc tggccggcac cggtttcagc 2079181 aatgattttc gttttgccca tttttttagc aagcagcgct tgacctagcg cattattgat 2079241 tttatgagaa cctgtatggt ttaaatcttc tcgtttcaaa tagattttcg cgccgcctaa 2079301 gtattcagtg actcgatcag cgtatgttaa tgcagtcggg cgtccggaat agtcctttaa 2079361 cagcttataa tactcttcac gaaaagcggg atcatccttg atttgtttaa atgctgtttg 2079421 tatttcatct aacggctgca tgagtgtttc cggaacaaac tttccgccaa aatcaccgta 2079481 tctgcctatt tcattcggat atggatacat atcggttcat cctttcttct aaaagcctca 2079541 tcagattctg atctttttgt ccgttttttt caattccgct ggcaaggtca attccttctg 2079601 gctgccattt caataggcgt gtgatgctat ccggattcac gccgccagcg ataaagcagc 2079661 gtttaccaat agccgcctgc tgatattccg gcacacattc ccaagaaaat gcaacaccag 2079721 ttccgcctct agaccctttt acagatgaat caatcacaaa gccgtcaaca ttatctttaa 2079781 agcgggctat ttcttgagtt gtgttatctt gatggtgaag cgccttccat atttcacagc 2079841 ctgtcagctt gcgaagagca gcagcatccg ccggtttttc atcaccgtga agctgaatga 2079901 cgtcgagctt caagctcttg gcaatacgtg acatcgtctc tattgattca ttaacaaaaa 2079961 cacctgcaac ctgtttttcg acacgaactt ggttcagcca ttttttcaca tcttccggag 2080021 atacttttcg tttgctttca gcaaaaataa atcctaggta atcagcctgt gattccgccg 2080081 caagctgcaa atcctttagt gaccgaatac cgcaatattt taatgccggt ttcttcacaa 2080141 cctcactccc taaacaaagc atggattgct ttacgctgag aagtttgtct catcaatgat 2080201 tcaccgataa gtacagctcg cgccccatgt tcattgacaa atgttaaatg ttctaaagaa 2080261 ccgattccgc tttcgctgac aagcaaggat tctttcggaa cgagagatgc gatttgttct 2080321 gtctgcttta cagatgtttc aaacgttttt aggtttcgat tatttacgcc gagaatgtcg 2080381 ggtgtgaaca ctttcaatat ttgttctagc gttgatgcat catgaacctc cactaacacg 2080441 tccatcccct tttcacctgc ttcaagatat aattcatgaa ggtgtaaggg atcaagcacc 2080501 tcgccgatta acaatatggc atccgctccg attcttcttg attcctctac ttgaagagaa 2080561 tcaataaaat cttttctaag tacaggaatc gaaacagcac gctttacgtc tgataaatag 2080621 ctgttttccc cttgaaaaaa cggggtgtct gttaaaacgg aaatcgcatc tgccttcgca 2080681 gcctcatagt cttttgcaat ctgcacaggt acaaaatcct ctttaataag cccttttgac 2080741 ggcgatgctt tcttcacttc ggcaatcaac ccgataaacc gattcgggct tgccagcgcc 2080801 tccttaaatg aacgtttctc gaaaggctgc tctaccggca gaaccagtgt tttcacttct 2080861 tctttctttt gtttgatgat tttttcaagc atagatctct tcctctttct gctttagtcg 2080921 ttcaagctgc gcggcagcgc ctccgcttgt aatcgtctct aacgccagct ccgttccttc 2080981 cttcagtgag gcggtaattc ccgccgtgta aatcgcagca cccgcattaa aagccgtaat 2081041 agataaagcg gaactgctgc ttttattttc aaaaatattc tgaatgagat aagcgctctc 2081101 tttcggagac tgcacctgta aatcttcaag tctgccattt gtgaaaccga aatcttcggg 2081161 tgaaacggta tactcccggc gctctccgtc ctttaattca atcacgtcgg tcggtgctgt 2081221 aattgaaagc tcatctaaac cgtcacggct tgatacaaac ataacgtgct tcggctgaaa 2081281 cgtctccagt gcgcttgcca tcagtccagc tttttcaaca gaatagaccc caatcacctg 2081341 acgcttcgcc tgtaaaggat tgctgagcgg cccaagcaga ttaaataccg ttctgaaacc 2081401 tagctctttt ctagtacctg ctacatgttt catagacgaa tggtaaagcg gcgcaaaaag 2081461 aaatcccatg ttgtttgttt caatgctgct tttgaccttt tcgggagtgg tttgaataga 2081521 aacctctagc tcctctaaaa catcagcgct tccgctttta gaagagacag agcgattgcc 2081581 atgcttagcg attttcgcac cagctgccga ggcaacaatt gccgaggccg ttgagatatt 2081641 aaaagtggaa ataccgtctc cccctgttcc gcatgtatca acaatatcag gaagtccatc 2081701 gactgtaaga gcgtgtgccc gcattgcctt cacaaaaccc gcaagctctt ctggcgtctc 2081761 cccccgatga gcaagaattg acaatatccc ccccatttca gaaggagtca tttccgctgc 2081821 catcatcata ttcatcagcg tttcagcctc accggcagta agggtttttc cgtcaacgca 2081881 caattgtaga aatctgttca tcagctttat cctccttgct atgaaacatg tcttctgcaa 2081941 tatgaatcgt tttcagcagc gcaccggctt tattacagct ttcttcgtat tcggcttccg 2082001 gaacagaatc agcaacaatg ccagcacctg cctgtatcga tgcaacaccg ttctttacac 2082061 tcatcgtgcg aatcgtaata caagagtcga tattcccgtc aaacccaatg taggcaatac 2082121 accctccgta tgtctctctc ggtgttggct cgagttcttg caaaagctgc atggcacgga 2082181 ttttgggtgc gcctgttaaa gtccccgccg ggaaagcaga catcagtgca tcgacaggat 2082241 gaaccccttt tttcaatcgg cctgtaacca ccgagataat gtgcatgaca tgtgaaaagg 2082301 aaacaatttt tgtgaactcc ggcacagaaa cagaaccata ctctgctact ctgccgatat 2082361 cgtttcgggc aagatcaacg agcatgtaat gctccgcttt ttctttttca tccttcatga 2082421 gctcaacctt cagtctctca tcttcagctt tgtctgcacc gcgttttctc gtaccggcaa 2082481 tcggatggat ttctaagtgc ccgtcttgaa cgtgtattaa ccgttccgga gagctgccga 2082541 ctatttctct gtctagcagt ttcatataat acatatacgg cgaaggattg acgatcctaa 2082601 gcactcggta taactcaaaa gcatctgctt ttatcggcac ctcaaatttt tgtgataaaa 2082661 caccctggaa gatatcgcct gcttttatat agcttttgat tttttctaca tcagccataa 2082721 aagccgattt ttcataatta gaagatactg tctcaaagct gggtgtcttg tatgaatcag 2082781 cagaaagaaa cagctctttt atgttttttt ggtccatcat tttttcaatg agattttgaa 2082841 gctccagatg attttgatgg aatacatcca ttttttcgtt ttttgtttcc tctccagtga 2082901 gccttgcata ttggataaag tggacgtttt tggtttcatg atcatacgca attaatgtcc 2082961 ggcaaacaaa cagcatacac ttttccatgt ctgtttcttt ggtatgcgaa ggaacagaag 2083021 gctcaatcag cgggatcata tcatagctta agtacccgac agctccgccg acaaaaggaa 2083081 tgccaagctc aggtgttttg attttgtatg tggtattcat ccagttcagc acttctttta 2083141 gttcatttcc tgtgtaaaga gatttgctgt cctgatcagc ggccgaaaaa cggccctgct 2083201 cttctttaat tgtgagaaat ggattcaggc cgataaacga atatctggac caagtggatg 2083261 tatcgtcctt gctttcaaga agatacgtaa tctccctgtc aagcttctct atcatttgaa 2083321 tgggtgtcag tgtatcgact gtgaaggtct ccacaatcgg tatcgtgtgg tgggacaagc 2083381 tgtcctctaa aaatgcggaa atgtttgatt ggaaattcat tgctctcact ccttatggca 2083441 aggagaatga gaagatggca tgagaggata aaatactata taacaaataa acccaaaaga 2083501 aagacttctt ttgggtagaa taaacataat gtctcagctc aactaaactc attctctgct 2083561 accctattct ctaactcaac tcattctaat tgctttatac acactcttgt gtatttctaa 2083621 gctgttctta tcgtattaca attcagtatt ttttgtcaat gataaatcgg gcctcaatac 2083681 gacaactttt tctaaatata catgtctgat ctgatcctga gggacatctg tctggaccgt 2083741 catcatgact cttatgcact ttttcagacc gcctgttacg tccatttcct gcatacatgt 2083801 taccggtaca tactgccatc ctgaaagctc gcgaacagct tttgccggga aaacagcgtg 2083861 caaatcaggt gtagccgaca gaagcatttg aacaacatct tccggttttg tatgattttc 2083921 ttctatgatt ttctctaaca gctgtttagt tttttgtaaa atttcttctt cagtatcccg 2083981 ttcaactgta gttgctccgc gaattccgcg aatcatcatg atgtctcctc caatcgccat 2084041 ttgttcagcc agctctcaag ttcatttctg gaaaatgtat gatcagcaac tttccctaat 2084101 tcgttgagca caataaactg aatcttcccg ccacgggttt tcttatcatt catcatacgg 2084161 ttcaagagaa ccgaagtttc cgtctctttt ctgatttgac ttggataacc caggcttttt 2084221 agccagctga ccaaacgttt tctgtccatt tcacagccta cagtcttttc gcttatatat 2084281 aaagcaaact gcattccgag ggctacggca tcaccgtgag tgatctgccc atatccatat 2084341 tccgcctcaa cggcatggcc gagcgtatgc ccaaagttta agtaagctct tatcccctct 2084401 tctttttcat cctgctgaac gacagacgct ttaattgaaa tgcctttaaa aatcatgtca 2084461 ttcagctgat cattagtgat atcacgcagt gagtggatat tcagcagctc ctccagaaac 2084521 gctctgtcat agataaaagc gtgtttaatc acttctgcca ttccggacct aagctctttt 2084581 tcaggcagag aacgcaggaa atctgtatca tagagcacgg ctttcggctg ataaaacgca 2084641 ccgattagat tttttccaag cggatggttc acggctactt ttcctccgac tgcgctgtca 2084701 tgcgccaaga gcgtcgtagg catttggatg aaatcaatgc cgcgcataaa agtggcagcc 2084761 acaaaaccgg caagatcccc tacaacaccg ccaccgaatg cgatgatgca tgaggagcga 2084821 tccatatgaa aacgaatcgc ttcactctgc aattttgtgt acatgtccat ggattttgcc 2084881 tgctctccac tcggtaccgt cacttttttc acaggccatt tttcttgcag caaatggagc 2084941 atttcatcac catacaggcg gtccacttct tcatccgtga caaacataat ccttgttaaa 2085001 ggcctgttta aagaggttaa tagttcgcaa gccttttttc tgataccttg tccgataaaa 2085061 acaggatatg acgaggaagc agtttgaaca tgcagtgtct tcattaaaat tccctcgaca 2085121 gttttctcat attctccaca ttttctctaa tgcggtcaat ttgatctaat ccgaattgtt 2085181 caacgactgc gttcgcaatt tcccaagcga cagccgcttc agcgactaca cttgccgcag 2085241 gaacagcaca gctgtctgaa cgttcaatgc tggcagaaaa cggttctttc gtttcaatat 2085301 cgacactttt cagcggttta tacaaagtcg gaatcggctt catgactccg cggacaacaa 2085361 tcggcatccc tgtcgtcatg ccgccttcca gtccgccaag tctgttagta gcacgggtgt 2085421 atcctttttc ctcgtcccaa atgatctcgt catggacttc gcttccattt cgccctgctg 2085481 cctcaaatcc gatgccgaat tccacacctt taaatgcgtt aattgacaga acagcggcag 2085541 caagcttgct atccagcttg cggtcataat ggacatagct gcccacgcct accggcattc 2085601 cctcgacaat gacttctact attccgccga tggaatctcc gtttgccttt gcttcatcaa 2085661 tggcagccat catttttttg cctgcctctt catcgtagca tctgacagga gactcttccg 2085721 ttacacgctg caagtcttca attgacgtat actctgtttt ttcagcttta acagcgccaa 2085781 tttgcaacac gtggcccgcc accttaatgc caagctcaga aagaatcttt ttagctacag 2085841 cccctgccgc cactctgaca gttgtttccc ttgctgaaga acgctcaagc acatttctca 2085901 tatcacgatg attatattta attgcaccgt ttaagtcagc gtgcccaggt ctcggtctgg 2085961 aaatctggcg cttcatttcc ttttcttcat cttctgtaat cggagcggcg cccatgattt 2086021 ttgtccaatg cttccaatcg ttattttcaa ctacgagagc aattggcgaa ccgagtgtac 2086081 gtgcatggcg caccccgctc ataattttgg cctggtcttt ttcgatctgc atgcggcggc 2086141 cgcggccgtg tcctttttgg cgtctggcaa gctcaaaatt gatatcttcc tccgttatgt 2086201 aaagcccggc aggtacaccc tcaataatgg ttgtcagttg ggggccgtgt gattctccgg 2086261 ctgttaaata tctcatgact tcttctccct tcatcgcatt aacgctttta agtaagacta 2086321 ctataacata tttttcagca aaaagtcagt ctatcttttt tgataaaaga atgtatcggc 2086381 tgggactagg ccaaatttct cgggattgaa gatttgctcg gtgctgccga caaaaagaac 2086441 tccattcttc ttcaagctat gtgccatttt taaatacagc tcttccttcg cgctttctgt 2086501 aaaataaata aatacattgc ggcacacgat taagtcaaag tcttgttcat aacgatccgc 2086561 cagcaaattg tgctttttga atgtaatatt ctttttgatt tccgttttca cttcataact 2086621 tctatttgcg ttttgcgtaa aataacgatc tttcacagat agcggcactt cctgtaaaga 2086681 ccgctcctga taaacgcctt ttttcgcttt ttccaatgct ttttcatcaa tatccgtcgc 2086741 taaaatctga tagcccggaa gacctttttg ctggtccaaa agcatggcaa gcgtgtatgg 2086801 ctcctccccc gttgagcagg cggcactcca aatttttaaa ggcctagagg tcttgattaa 2086861 cggcagaatt gcagtctcaa gaacttccca tcttttataa ttacgataaa attctgaaac 2086921 attgatcgtc attctgtcca atgtttcatt taagagagct tgatcctttt ccaatgccgc 2086981 agcaaagtcc ttaaagcttt ggaacccctt tttctcataa agtgacgtta gccttctctt 2087041 catttgtgct tctttatata gtgttaaatc gactccggtt aattgtttcc atttcgttgt 2087101 aaatacgctg tatgtatcca tctctactct cccagtctcg ctgtcttttt gtcctagtat 2087161 agcttgtttt atcaggaaat tgtattgttt caataaaaaa atcagctttt cagctgattt 2087221 tagatcgttg ggaaaggcag aggtctgatg cacactgcca ttcaaccctt tattcacttt 2087281 aatgtaaacc tttacaaaac agaacaaaaa ccggcggcgt tatatgttgc cggctctgtt 2087341 gcttattttc acaatgatta atagatccag cctgccataa gctgctgata tgatactaat 2087401 tcttcattct taaagaaaat gttaatctcg cgttctgcac tttcgagaga atcagagccg 2087461 tggatgatgt tttttccgac aaacatgcca taatccccac gaatcgtacc aggtaaagct 2087521 tctttagggt ttgttttccc gatcagctgt ctcgtcactt caatgacatt ttcgccttcc 2087581 cacaccattg cgaatacagg tcctgaagta ataaactcaa cgagctctcc gaagaaaggc 2087641 ttaccttgat gttcggcgta gtgtttctca gccatttgtt cagtcactct cattaacttg 2087701 gcgccagcta attgtaagcc cttacgttcg aatctagata aaatgtcccc aatgagctga 2087761 cgttggacac cgtctggttt caccatgata aaagtctttt ccatcatatt ctccacccca 2087821 tcattatgta tgtataggct ttcacactgc acaccgaaat cgtaacatct ttctgataat 2087881 taatcaatcc ggggcggaga aatttcttaa tatctacaaa aattaaaatt ttcttttacc 2087941 gatatatttt gcgatggctg caagagacga gcgtgcgcgc cctcgaggaa gcgtgtttaa 2088001 tttctgaaaa gctttctgca gatacatttc gcttactgcc atagatgctt caattgcatc 2088061 tgtttttttg atttcttcaa tgattggttc aagctgttcc tgcgttgtct cactgttaat 2088121 caatttaagc tggtttttta atgcaggatt tttcagggca tacagcactg gcaatgtgac 2088181 gtttccttga agcaaatctc ctcctacggg tttacccagc tcttcctcag ttgaagtaaa 2088241 atcaagaata tcatcaataa tctgataaga catgccgacg taatacccaa accagtacaa 2088301 tgccttatga atcttctcat cagctccaga cgcaatggca ccaagctggc agctgaccgc 2088361 gatcaagaga gctgtttttc ttttgatacg gcggagatac gttctgagat tttgttccat 2088421 gttgtatttg tctttgatct gctcaatttc ccctagacaa acttcaacga tcgtctgtga 2088481 caaaatccta tgggctttcg gttcgttaat tctcgtcatc atttcaagag atcccgcaag 2088541 catataatcg cctgtgtaca tcgcaatacg attgtcccac tttgctttga ttgtcggttt 2088601 tcctcggcga agctctgcat catcaatgac atcatcatga accaaagatg ccatgtgaat 2088661 catttccaga gtgacggcga catatttaat cttattaata tcataatcgc caaacatgcc 2088721 agaaagcagc acgaaaacag gccgaatacg tttccctccg gcctgcagca ggtgaagacc 2088781 tgcctcgctt aaaagcgggt aatcggaacg tacggtttgt tcaagttctc tttcgattac 2088841 atcaatatcg tcatttaaaa aagagtaggc cattttaaat ttcatatcat tcacccaaac 2088901 atctgtgttt tcatttccat ccgatatgcg tggcagcgac tccgccagta aacgaatgat 2088961 atttaacatt tttcaggccc gcctcttcaa acaggcctgc cagttccttc attccaggga 2089021 aatctctggc tgattcttga agccaagaat attctttata gctcttcgca aacagtttcc 2089081 cgaaaaacgg cataatatac ttaaagtaca taaagtaagc ctgtctgaat ccgaacattt 2089141 ccggctggga cgtttccaga cataccacct gcccgcccgg cttcactaca cgtctcatct 2089201 ctttcagtac agtcaagtaa tcagggacat tgcggagtcc gaagccaatg gtgacataat 2089261 caaatgtatc atcatcaaaa ggaagctcca tcgcatttcc gtgcagcagt tcaatttggc 2089321 tgaatccgcc gtcttttact ttctgctcgc cgacactcag catattttca ctgaaatcca 2089381 agcccttgat ctcgccgctt ttgcctgccg cttttgcaag agcgatcgtc cagtcagccg 2089441 ttccgcagca gacatcaagt gcttttgcgc cttcctttac attcatgatg cgcatcgttt 2089501 tgtcgcgcca ttttttatgc tgctgaaaac tgatgacaga gttcatttgg tcataatttt 2089561 tatatatttt ttcaaatact ccgtgtacgc gctgttcttt tgagtcctgc ataatggttt 2089621 acccttcttc cactttctga tgataggttt gatcttggct gattgtcttc agacggttta 2089681 ttaaaatgtt ctgaataggt gaatttagag gcagaagtga ctcaatgctg tttttcgctt 2089741 ttttaaaaca atcttctaat atctcttctt ttgtttttcc cagctgtata aaactgccga 2089801 tcacatccag aaatgcatca tttccgttca taagccgctt aaatacaaaa aaatcactcg 2089861 acagcttttt ccagcgcggg aggttgaagt gttccgccac acgatggaat aaagctgatt 2089921 caacgatgcc gacactttcg aaaaaatcgt tttcgtcctt gaaagaacgg tcatacagac 2089981 gaattttatg ttcgttgatt tctttaatgg ctgtagcaag cgtccgaatc atgtagatat 2090041 ccttcatttc agatagtaaa gagtagtaca gcccgctgaa ataatcgccc gcgagaacag 2090101 tcaattggcg gtttttgttt tcgtctcgtt ttatgactct agctgtcgtc acttcatcat 2090161 gggtatcaag ggcgctttgt acaagcatcg ctgttacaat ataattttct ctgtcgttgt 2090221 tttttatgtc ggcttcttca aataaagcat gaaaaagaag aagcttatcc tcatcaattt 2090281 tcggcgcaga aatatgcttc gctaaataag gatgagacag cttttgtttt aatttcgtgt 2090341 tcagattggc taaagttccg tagatgtctt gcaaaaatat cacccttgtc cccaaattca 2090401 catttatttc ttaatctatg tatgagtttt atcttttcat tcgcttacgc aggtatcatt 2090461 atagcataaa aaaaagaaat tggctgtatc ctcccgctgt ttgcgagcat ttgcttttaa 2090521 cagcggggac agccagctta ttttttttcg cttttcattt ctccgtacgc ggtttgaatc 2090581 agtgcctctc ctctgacttt aatggcagaa gtatgctctg taaactgagc gatgatcact 2090641 tctcccttgt cgagtttttc ggaatggtga aactttgtgt ctgttcctct tgtcaggccg 2090701 atcacattca ctccgtcctc aacggcttta atgacgacaa aatcacttga atgcttttgg 2090761 ttcatttata gcaccctcta tctttattag tcctggcgtt taatatgttc caatacttct 2090821 gcacgggcag cggcatcatc tttaaaaacg cctctgactg ctgaagtcac agttttcgca 2090881 cccggttttc ttacaccgcg catcgtcatg cacatgtgtt ccgcttcaac cactaccatt 2090941 acgccatgcg gatcaagcgt ttctacgatg ctttctgcaa ttgtagaagt gatgcgttcc 2091001 tgaagctgcg ggcgctttgc aacggcttca acggcacgtg ccagtttgct gagtcctgtg 2091061 acctttccgc ctcgcgggat atatgcaaca tgtgcttttc cataaaaggg aacaaggtga 2091121 tgctcacaca tagaatgaaa cgctatatct tttacaagaa caagctcctc atggttttca 2091181 ccgaagatag tctggaaatg ttcttttgga tcttcattca agccggagaa tacttcggca 2091241 tacatctttg cgactctttt cggagtatca agaagccctt ctctattcgg gtcttctccg 2091301 atcgcttcta aaatttgacg aacagcttgt tcgatttgct ctttattaac ttctttcatg 2091361 ttctatgtcc tccaccaatg aatacattta atttcgattc tagcacatat gccccgctaa 2091421 aagcaaagtg aatgccctgt caggaagccc atgctcttga aatatgaaaa gccccttaga 2091481 aaggggcttt tctgtgaaga aataaagtgt atgtaagcta gatgcataca cgatctatat 2091541 tcacaattat tttccggcaa ctgcgtcttt aagcgcttta cctggtttga aagcaggtac 2091601 tttgcttgct ggaatttcga tttcttcacc tgtttgagga ttgcgtcctt tacgtgcaga 2091661 acgttcacgc acctcgaagt taccaaaacc gatcagttgg attttatcac cgtttttaag 2091721 tgcatctaag atcgtatcaa aaacagagtc aactgctttt gtagcgtctt ttttagacaa 2091781 ttcgcttgct tctgcaaccg cattgataag ttctgttttg ttcatgcctt tcacctcctc 2091841 ccaaaaggat acattcagtt cgtttattat catttcttca cagttcagtc tgattctaaa 2091901 cctgtctcag aaaaaaatga gagcaagtaa gagaaagaca attaaacggc tttttaagaa 2091961 aaactgcact ctgaggaatg tttgtccaac aaagtgaaga atttctgtat gtagagtaac 2092021 acatataaaa agccatatca agcattttaa agcgtcaatc ccttgctcgt caaggattta 2092081 aggtgattta ccgaacgaat attccttttt ttcctttttt catcctattc cttgatcctt 2092141 ttccattatt aagagcaaag aaaaaagacc tcccattcta taaagaggtc taccggtatt 2092201 acaggatgat ggcgattaag ccgccagagc cttcgtttat gattctttct aatgtttctt 2092261 ttaatttata ccgtgcgttt tcaggcatca atgacagctt tgcctgaatc ccttctctca 2092321 caattgagct cagcgacctt ccgaagatat cggaattcca gatggagagc ggatcatcct 2092381 caaagtcctg cattaaatag cgtacaagct cttcactttg tttttccgtt ccgataatcg 2092441 gggcgaattc gctttcgaca tctactttga tcatatggat cgacggagcg acagctttca 2092501 gcctcacacc gaatcgcgag ccctgcctta taatttccgg ctcatcgaga ctcatatcag 2092561 ctaaagcagg cgctgcaatg ccgtatcccg tctgtttgac catttttaag gcatcagaca 2092621 cttgatcata ttctgttttc gcatgggcga agtcttgcat gagctcaagc agatggtctc 2092681 ttcctctgat ttcgacgccc acaacttctt ttaggatttg atcatataga tgatcaggcg 2092741 cgtacaaatc aatttctgcc accccttggc ccagctcaat tccggctaat ccggcacttt 2092801 caatgaattc aaactcgctg aattggccga caaccctgtc tacgtcccgg agccgtttaa 2092861 tatccttaac cgtttccttc acggactcct gatagctttc acgcaaccaa tggttttctt 2092921 tcagcaccat tacccagctt gggagattga cattcacttc tagcaccgga aactcgtaga 2092981 gggcctctct gagcacactc agcacatctg attcccgcat gctctctaca ctcattgcca 2093041 ataccgggat atcatatttt tcgcttaaat cctggcgcat ggcttccgtt tccgggtgat 2093101 acggcctgac tgagttgatg accataataa aaggtttgcc aacctctttc agctcttcaa 2093161 tgactctttc ttcagcctct atatagtcac ttctggcgat atctccaatg gtgccgtctg 2093221 tcgtaatgac aactccgatg gtcgagtgtt cttgaatgac ttttcgtgtg ccgatttcag 2093281 cagcctcatg aaatgggatc ggttcttcgt accaaggcgt attgatcatc cgcggcccgt 2093341 tttcatcttc atatccttta gcgccgggca ctgtgtaacc tacacaatct actaatctta 2093401 tattcacatc gagtccgtct gacacatgaa cagacatcgc ctgattcgga acaaatttag 2093461 gctctgtagt cataatggtt ttgccggctg cgctctgcgg cagttcatcc tgcgctcggg 2093521 cccggtctgc ttcgttactg atattcggga gcaccacaag ctccataaat tttttaatga 2093581 acgtggattt tcctgtacgg acagcaccta cgactcctaa gtatatatcg cctcctgttc 2093641 gttcagcgat atccttgaaa atatcgacct tttccaagtg atcccctccc ggacttccta 2093701 tccttttcaa ttttattaag ctctttcaat caaacacagg acactatatg tgtatgacgt 2093761 tgtcctattt gaatatgaca tctttagaaa atttctcatc ctcaatctat taatataaaa 2093821 aaacctttct ccctatttgt atgcaaggga gaaaggttca ttcctttttc atatcatttt 2093881 ctaaaaaaac aggttcctgt ttgtcattta ccgtatattt tacagaaaac gcggggacaa 2093941 agggggtttc atgccaaatc atatcctgga tttcagtccc gggtttaaac gtttttttgc 2094001 tttttttgag gcaagaagcc agctcagtcc ggtaatcggc atatatttct ccgtctccgt 2094061 caatcataag cggcaaggaa ttccctgaga ttgggcttgt cactgtaaga gagctgccat 2094121 ccccaagctt cttctcatcg agtgtaaata aatcacgaga tagcacatcc ttgtaaggcg 2094181 gatattgatg ctcctgacga tacatttgga tgcgcaattt cacatcgcga attttttctg 2094241 ccatctttag atcaattaat ttaacagtcg gatcgttctc tacgtcaaca agcacgtatt 2094301 gatagtctcc cccgctttca aatgccgtac ttggaggttc agctatgtat cttggcgcta 2094361 accggttaaa gtctatcgga tatttttgat atagcggtgt cgacatatct ttggtttgaa 2094421 taggaagcag ccctccattt gccttttgaa attcatcaac agcagattga acctgcttta 2094481 gctggtcttg ataaggaatg gcatgcacac tgcttttccg ttcatttgga tataaacatc 2094541 cggataaaaa cacgactgcc gcaaaaatga ttgcgcactt cagtttaccc atacagcact 2094601 tccttttaca gctttattca ttgacagggc cgctaaaaac cacgacaaac acaataattc 2094661 cagatatgag catacacatg tatgcgaatg atgaaatcgc aatcttcaaa aaacggtttt 2094721 ggcacttaaa gcggcttaaa tagatggaag ctacagccag aaacatcaga cccatggacc 2094781 ctagagcaaa ccacattttc atcaatgcca gattcaatga cgtgcgcctc cccgatatgt 2094841 aagatataag cgttatatta tattttaata tacagcgccg gaaaagatca accagatttt 2094901 ccatccattg atagaacaaa aaaactgaag caaagagggg gaccttcgct tcagtcaact 2094961 tgactatatt cacctgcacg tttaagaaac actctcttgg acttcgatgc tatagtatgc 2095021 gacttggcat acagatgcat cctctattgc ctaaatcggc aaaatgtttc aggagatccc 2095081 aagacttggg tgttcttctg tttttcgggc tttcgttcaa ttaagatatg cgattcacca 2095141 tttgattgac acttttactt cacttgattt tcaaacgtat ttaccaaatc ctccatctcg 2095201 tgggttttcc ctctcgccat taaagattca acagcggttt ccactttttg tccgttgaat 2095261 aggacctgat ggagagcttc tgtaatcggc attttaacat catatttctt cgaaagctga 2095321 taagccgctt tcgtcgtgcg gacgccttcg actaccattc ccatctcttc aagaacatct 2095381 tcaagcttgt acccttttcc gagcaaattg cccgcacgcc agtttctgga atgaacactt 2095441 gtgcacgtca caatcagatc gcctactcct gtcaatccag agaacgtcaa gggatttccg 2095501 cccattttcg ttccgagtct cgcgatttcg gcaagtccgc gtgtaatcaa agcagctttg 2095561 gcattgtcac cgtaccctaa accatctgta attcctgcag caagggcaat aatatttttt 2095621 aaagcccctc cgatttcaac tccgataatg tcaggatttg tgtacacccg aaaattgtga 2095681 ttaataaata gatcctgcac ctcttctgct gccctcatgc tctttgaaga tgcagtaaca 2095741 gttgtggggt gccgcagccc tacttcttcc gcatgactcg ggccggaaag gacaacgata 2095801 tcttttctga catcactcgg gagctcaatt tccataattt cagaaatgcg cagaagtgaa 2095861 tctggctcaa tacccttgct gacatgaaca aagactgcct ttttcgttat aaaagggaca 2095921 gcctgtctca gcacttcccg aattgctttt gtcgggaccg caacgataat gacatctgcg 2095981 tctgaaacag cctctttcat atctgttgtt cctttaatgg atgtagacag cttaacattc 2096041 ggcaaataat ctttgttttc atgcaactca ttaatttgat gaattaaatc tgcacggtga 2096101 gcccacacac acacttcatt tccattatca gttagaacta aagccagtgc tgttccccaa 2096161 ctccccgctc caagcattgt gacttttttc atgtttgatt cacacctttt tattttctag 2096221 ctcttgcaaa tattttgatt ggtgtcccct caaaaccgaa cgcgtctctg attcggtttt 2096281 ctaaaaaccg ttcgtatgaa aaatgcatca gttccggatc gtttacaaac acaacgaagc 2096341 ttggcggctt taccgacact tgagtcgcat agtaaatttt caaacgagaa ccgttatgag 2096401 tcggtgtcgg attcattgcc acagcgtcca tgatgacatc atttaagacg tttgtttgaa 2096461 ctcgaagtga atgattttca ctagctttga taatcgcagg catcagagta tggatccgtt 2096521 ttttcgttaa ggcagacata aataggattg gcgcataatc cagaaattga aaatgatcgc 2096581 gaatattttc ttcaaattct ttcatcgtgc tctcatcttt gtcaacagca tcccatttgt 2096641 ttacgacgat gacgacggcc ttgcccgctt cgtgtgcata accggcgata cgcttgtcct 2096701 gttcaataat gccttcttcg ccatccagca caaccgccac gacttctgag cggtcaatcg 2096761 cttttagcgc ccgcagtaca ctatacttct cagtcgtttc atagactttc cctttttttc 2096821 gcatacctgc agtatcgaca atgacaaact cctgctggtt gtaagtaaat gacgtatcaa 2096881 cagcatctct tgtcgttcca gccacgttgc tgacaataac gcgttcttcg ccgagcatcg 2096941 cattcacaag tgaagacttt ccgacatttg gacgtccgat cagacagaat tgaataactt 2097001 cttcattgta tttcgtttca ggaatgtttt taaaatgctc tgcaacggca tccagtaaat 2097061 cacccagtcc gagtccgtgt gttcccgaaa ttggatacgg ctcgccaaag cctagcgaat 2097121 aaaaatcata aatattcgct ctcatttctg tgttatccag tttattaacc gctaaaacaa 2097181 caggcttttt tgtgcggtac aaaattttcg ccacttcttc atcagcagct gtcacgcctt 2097241 cacggccgtt caccataaaa ataatcacgt ccgcttcatc catggcgatt tcagcttgct 2097301 ggcgaatctg cgctaaaaac ggctcatcac cgatatcaat accgcccgta tcaatcaaat 2097361 taaaatcata attcagccat tcagccgagc tgtatatccg atcccttgtc acgccagggg 2097421 tatcttctac tattgaaatt ctttctcccg caatccggtt aaagattgtg gattttccta 2097481 catttggtct cccgacaatg gctacgacag gtttacccat agtacccttc ctttcaatcc 2097541 agccgctttc atttttacat aaattttcaa ccggttatta aaatcatttc attcactttt 2097601 atgaaaagaa acccttcaga ggaagggctt aactcattta ttatatcagt ttttactggg 2097661 atcacaacta ttcttaaaaa tgtttcacga tcaaatacac gtcatctccg attctgtgag 2097721 ctattccatc aaggatcgcc tcaagatttt tagcgaaaag ctccatctcc ttttggtcat 2097781 tgcaaaaaaa gacaggtgct ccccctgcaa cccgatttcg atttgtcgtg attacagaca 2097841 aaatcacttt cgtaagagat tcactcatcc tatcacctta tcctgattct tgataaattc 2097901 agtcggcatt ctaatcgcat tttccagggt tggaacattg ctaataattt gaacagccgt 2097961 ttcgggatgg tgaatttgcg ggagaacaaa tactgccact ctcccatcat ttaaatcccg 2098021 ttttgcaatt ggtgtcaaag atggctctcc tgaatcccga taaaccccga gcacattgga 2098081 aacatcaaat aaaatggcct gacgctgccc taaatttgct atcgtcgctg ctgaattaaa 2098141 gtttttcggc gtcaaaataa agcccatgcc atgctttaaa atcagttcct gtttctctgg 2098201 aagcccgata ttcatcatat aaatattatc aacaaacagt cccggaccgt caaagcgcgg 2098261 ctttatgtac tcgatatcta caatatcctt caacacactg cccgacataa acttcatggc 2098321 cagtaaaaaa caaacgacag ccgctatgac tgcagcccag atggataaaa acacatacgc 2098381 agaggttgtc aaaagcgctg taaagatcac aatataattt ctgctttcaa acgcaatggc 2098441 aatcccctca atatatgtgc ttccccttga gacaagttca tacgaatcca tttgcgtcaa 2098501 tgtgttccgc tccatgtttc ggacatctct aaattgcgtc gctgccaatg ttaaaaatgt 2098561 gatggccgta aattcctcct gcaaaagcgc cggcataata attgcaccta aaccagccgc 2098621 tatcaacccc agtgcgatgt gaatcacttt cccatgaaca taggtcggat actggcggta 2098681 atccgttttc agcatataaa gccttgtcgc aattccggca atgaccccag caataatcgg 2098741 atagatgtaa tcactcatga cattttggta gctcctttgt ttgatctttt gcttttctga 2098801 ccaatctggc ttgcgaggtg ttcgtattta gatatgccaa acagcaatat catccccgca 2098861 gaacacgcat tcagccattg aaagccgccg acagccatag ccccggccaa cttctggatc 2098921 acaaatgaat acaccagttc gccttggcac atccctagga caaataagac aagctgcttc 2098981 tcaaaattcc tttcaacaga agctgttaaa agcactatta atataacagc agcccactca 2099041 ggttttatga tgaaccaaac cgggtcatat aatgcaaaaa gataaacaaa cgcatacgcg 2099101 gcaacaagcg tcagatagac catgatgtaa cgaaaacgat acattcccaa atacccggca 2099161 tagacacatc cgcaaacgaa aaacatcaaa tatgcagcat tcagggaaaa atataaagcg 2099221 atgtcatgta tgcttagaat aatattagtt aaaataaaga cagagacggc aattcgtctt 2099281 ttcgtctttt caaaaataaa tgttgtcaga acccacagaa accacattga ccaatagtaa 2099341 taaaattgtt ccattttact tcctccatat tcccagtatg gagttcaagc acatttttta 2099401 aacaatcgat ctcacattaa ggagtatgat catgggaaaa gacagacaag agaaaaaact 2099461 caaagcttca ggcagagtcg aatcagatcg cgaccagtcc attcactatg acggagcgac 2099521 aagccttgaa caaaacggaa gattcaaaaa gcgaaaatca taatacaaaa agcccaaacc 2099581 acatatggtt ttgggctttt atcatttatc gcacactata gcttgatgta ttgacccctc 2099641 tctctgtgag ccaatgatgg gtttcacctt tgatcacaag gggcgccttt tgtaaatcgg 2099701 caattgttct ggcacccagc acggtcataa tcaactttaa ttcctcaagg atcagctgaa 2099761 tctcctcaag cagtccttcc tcaccgctgt cagtcagcgc ttttaaaaaa tgccctgcca 2099821 ttccggtgca agaggccccc agcgcaattg cctttgccac gtcaagcgca tcttgcagac 2099881 cgccagaggc gatcatggtg cttgcaggaa actcagagcg gatttccgcc aaacttgcag 2099941 ctgtcgaaat gccccacgaa ttaaaaaagg agatttgccg ctgtcttcgg agattttcga 2100001 ttttcgagaa atttgttccc ccgtaaccgc caatgtcaac agctgcagca ccagcttcat 2100061 acagctttcc tgctgatgct ttgctcatac cgaagccgac ttctttcaca atgaccggta 2100121 cactgacccg gctgcaaatt tgttcaatgc gtttcaatgc gccgctaaag cttctgtccc 2100181 cttcaggcat cacaatttcc tgaatcacat tgaggtggat ctgcagtgcg tttgctccaa 2100241 tcatctcaac ggcttccttt gcctgagcag ccgttgcctc gcttcccagg ttggcaaaaa 2100301 tcagcccgtt tgggttttcc tttcgaacaa tttcatagga aagacgctct gatggatctt 2100361 ttaatgctga catttgcgat cccacagcaa ggggaattcc agcctgagaa gccgctcgcg 2100421 caagcgattt attaatctca tatgtaagtt ttccgccgcc gccagtcatt gcattgataa 2100481 aaatcggcga actgcttgaa agttcgccga tttttgtgga aatatctact tgttctaatg 2100541 caagatcggg cagactgacg tgaacaaacg taatatcatc aagacctgtt tcccgcttct 2100601 ggccgatgga caaggcatga ttgatgtgtt gtctttttcg ttctgctcga gtcacgttta 2100661 tcaccaatta ttttagttta ttcagcttat ctccgatcag atctccaagc tggaagccag 2100721 tgcttgtttc ttccttcgct tgatattgac ggtaatcttc ctggtcagct ttaggcgttt 2100781 cttcaagttc acgcatgctt aatgaaatgc gctcctcatt ttcattcaca tcaagaacct 2100841 tcacttttac agtctgtcct tcttcaagga cttcatgcgg cgtgccgatg tgtttattgg 2100901 aaatttgaga aatatgaacg agaccttcaa cacctggaag gatttcaaca aaggcaccga 2100961 agcttacaag acgctgtaca gttccttcaa gcacatcgcc aggcttcact ttttcgccga 2101021 tttggttcca aggtccaggc agtgtatctt tgatcgataa agaaatacgt tcattatcac 2101081 ggtcaaccga taacactttc acttttactt cttgtccctc ttcaacaacg tcagacggct 2101141 tctctacatg agagtgggaa agctgtgaaa tgtgtacaag tccgtcgatg ccgccaatat 2101201 caacaaacgc gccaaagtca gtcaggcgct gtactttgcc atcaagtaca cttccaactt 2101261 caagagactg aagaagttct tgttttttat tcgcttgttc actttcaaca acagcacggt 2101321 gtgaaaggat cacgcggttt ttatcacggt caagctctac aacgagcagt gacagtgttt 2101381 ttcctttata gtcagtgaag tcttcaacga aatgtgcttc aacaagtgat gccggaataa 2101441 aaccgcgaac gccgatatca acgacaaggc cgcctttcac gacatctttc acttcagctt 2101501 caaacacttc ttttgtttca aattttttct caaggtcttc ccaagcgcgg tctgcatcaa 2101561 cagcacgttt agataaaatc aaagcatcgt cttccacttt tgttactttc aggtcaagct 2101621 cgtcgtctac tttaacaaca tccgatgctt tctctacatg aagacttgat aattcactga 2101681 ttggaataat accggattgt ttgacattga taatttctac atctacatgt ttgtcttcta 2101741 cctttgtcac aatcccttta actacatctc caacctctgg cacttgaaca tcaatttgat 2101801 tcatttcctc tgtcatttga ataacctcct tggtccaaac ctacacagct taattaaaac 2101861 ggtttgaaag ctgaacatat aacatgcccg cttttagccg aatatgtatt aaagaatcat 2101921 ccaaaaaagt tttttgaatg atcaataaaa agttttatta gtattaactt ctaataaaag 2101981 gacaggtttg tcaagcaata acattctatc ttcgttgaaa aattcaaaaa aagtggcatt 2102041 tgccatcctc agcgggactt ttgctccaca gcctcgagga ttttatcagc tacctcttga 2102101 atggaaagcg atgtcgtgtc gatttcaaga gcgtcttctg ctttacgcag cggagatact 2102161 tcgcgctctg aatcaagctt gtctcttctt gcaatttcct caattaatgt ttcgtagttg 2102221 acatcaaagc cttttttcac attttcttca taacggcgtt tcgctctctc ttccacagat 2102281 gccaaaagaa agatttttac ttctgcattt ggcagcacat gcgtcccgat gtcacgacca 2102341 tccatgacga cgccgccttt ttccccaagc tgctgctggc gtttcaccat ttcttctctg 2102401 acacttctgt gcttggccgc aattgaaact tggttgctga tttcatctgt tctgatcgcc 2102461 tcagttacat cggtgccgtt tacaaacact ttttgtccat cttttgttgt aatcagctca 2102521 atgtctgtcc gctttagcag ctcagccagt ttttcttcat ctgtcagatc aacgttttcc 2102581 tgtaaagccg cgtacgtaat cgcccgatac atcgctcctg tatcaatata tatgtacgat 2102641 tttttctcag ccacaatttt ggcaacggtg cttttccccg cagctgccgg gccgtcgatt 2102701 gcaatcgata atttcttttc cataattcct ctccttgctc ttttctcctc taaggattgt 2102761 atcacgaact ttatgaaaaa gggtgaaaaa ttgatgaata attaatgttt gaaggtttca 2102821 atcctattgt tttcctccat tttatccacc ccttcatatt gaatcacttt tgatacgtat 2102881 ggttcaatat gctgatagtg aaaaagaaat tggacaccaa gtaaaatgat ggcctgaatg 2102941 aacaataatt tgatcagcag ccgttcaaat gttttcattg gagcacctcc attacaaata 2103001 gtatggaagt gtttgccgat gtttattcca ttcgggcctt tcttctctta tttaactggc 2103061 gcctgatgca gtattgaagc aaagcctgct ggtcacctgc tgcaatttct gaatactcta 2103121 aagtcatttt tcgtttttct gacttggggt cattaaagat tcgtctgaca actgcttctg 2103181 tttctatttg acgtgtgtgc tcctcttcag gaagacggat gatcaggcgc aatgattccc 2103241 ccgattgaaa agaaaggcca tcagctaaaa ccacggcgat gccgcctgca ctgatgttat 2103301 aggatagtgt gcggatctct tcttcatttc ccggctgaat ttgcacatct aataccgcat 2103361 cagttcttac atattggcgg cgctggattc ttttcatttt ttcacgggga ggcatttcaa 2103421 gacagatcat ttgaagtttg tccttcactt taccttttat acggcttata aagcgataag 2103481 gaacttcgtc ttttcccaca aactctaccg ttacttccat atcgttatgt aaaatcacag 2103541 ttcgccctgt aactacatca acaggatacg cgatcaaaag ttcattgttt tcgatgctga 2103601 ccgccttgct ttttgccttt ttcaattcat tttcttctat atattctaaa agtacatttt 2103661 ctccaatctc tatcattgac ttcactcttt cgcattcaat atactcacgt ttttattaaa 2103721 gcacgtaatg aaaaaaagga aaagacattt agtcctttcc tcctgttttt ataggtcttt 2103781 atatataggt tctgcatttt ttagtttttc aaccttttct tccgatccgt ctttggcatt 2103841 gatatacatt ctgaatgtgt cattttcaat tgtcccaagc atttcgtagc ataacacttc 2103901 ttgacctagt tcatttgtaa tcaaagcgag ccttgtttct ctcacttgta catttttatt 2103961 taatttagac tttgcctctg cttcagtaat tgcaggctta ggtatggttc tttttctgtg 2104021 agatgtgagg aagtctcttg ctgaaaagcc gacaacctca ccgtcatcca aggccacttt 2104081 catacgaatt gcctcggggt acatccggac tttattttca acaggaacat atgaaaatac 2104141 accgatttta tcatattggg cactttcatc aatttccaaa tcatctgttt caaatccgtt 2104201 tttctttaaa aatgcaagcg ctcggttcga tccgtcattt aaactgattt tctgatcttt 2104261 cacttctctg ttttggatca agtataccgg atgcccgccc ttcttcgtaa tatccatata 2104321 aatcactgct ttatggtctg ggtctttcat gctgatgcta tatacatcgc gatttgtttt 2104381 ttttccgctc tttaccactt taattgaata attgtcatct ggggcaaagc gctcagcaat 2104441 ttgttttgct tcctgttcgg aaatttgttt tcccttcaga tggctgaagc ctttctcttc 2104501 ttttttcgta ctggtgaaac tcgggccaag atcagtgcca gtggagaatg caccaacatt 2104561 tttttcgact gttttaaagc tgttgataat cgtattatca ctttgttttt cgtcagaagc 2104621 cagagccatt tctacgtcca tccagcgaag gtttttgctc atgacaaggt gctgaacatg 2104681 acgcaattca ttttgtatat cttcggactg ctgatatagc ttatttagtg atgtatactc 2104741 gtttttatca agcggctttt ggtccaaatc tctgactgac gttttatagc tgaaatcgcc 2104801 gatctttgat aatagctctt cagttttatt aaacggcatt aatgtaagcg gcagctgact 2104861 gacgctgtta tgagcttctg atgtaatcct ccacacatcg atcaatgcag gcgacagtga 2104921 tttttggctg ttcatggcaa gtgttgttcc gattttatca tgaagctgat ccacctgata 2104981 ggtaagctca tgaaacgccc gctgatagtt attttcagca tgaagaagaa ctgcgtcttt 2105041 ttcctggtgt tctttgtatc cccagtagcc tgtaccgact attgcaatac caagcacggc 2105101 gattaaaatt cctctgatca tttatcacac ctctttttat gctttctcat atctgctact 2105161 cacagaaaat gtgtttaccg attcttttaa tctgcggacg cccccaaatc cacggacttg 2105221 tagccgtatc cggattaaag tagtaaagtg cttcctctga tgggtcccag ccattgatgg 2105281 catccagcac tgcttctcgt gccgtttcat tcggctgcat gtaaatttgt ccgtcggcta 2105341 ctgctgtgaa ggcaagcggc tcaaaaataa cccccgctac tgaatttgga aataacgggc 2105401 tgttcaaacg gtttaaaatg actgctgcaa tagcaacctg cccctcgtac ggctcgcccc 2105461 gggcttcgcc ataaaccgct tgagcaagca gcctgatatc gttgttggaa aatccaccag 2105521 gcatgttcgc tgctaccgca tcctgttttc ttgcttttgc tggtgtattg ttttgctgtt 2105581 tattcgcatt cgctttaggc ttctgcgttg ttttttccgc aggctgtttc tgccgtgctt 2105641 ctgcttgttg tcttgccttt tgtgttgctg cttttgatgg tttcgtctga tactttagcg 2105701 gaatttttcc gtaatgcgtg aatgtattcc ctttattgag ctgttccatg acatattcac 2105761 gatagtattt tgatttacat attaaggttt gctttgtttt agctcctaca aggccgtcaa 2105821 cctcttttaa cccgaattga tcctgaaaat ttcgaactgc ccagtacgtc ccccatccat 2105881 aaaccccgtc aatttttccg ttataatatc cgttgtattg aagacgcgcc tgaagctcga 2105941 ccacatcatc ccctgttgcc cctctttgaa tgacctgatt cgaaaaggca gagatcgttt 2106001 cagtattaat aaacgtcgtt attgtaaagg aaaaaaggat gagacatgcc ataatcgatc 2106061 ctttggactt catcttttca agcctcctac tgcaaatttt taagtgtaat cgtattttct 2106121 gtaacgaggt tatttttata cactctttcc ttgttatccc tcagaacata aaaactgcac 2106181 acaaaaaagc cgcacggttg ctgtgcggct tctatacttg catcatatta acggaacggg 2106241 cttttttcgc tttacgcaaa ccaaaccacc ataaaaatac cataaatgga agcatataat 2106301 aaatccaatt gctaagcgct gttaggataa aatcatatga tccatgcaaa agggatggga 2106361 caactaaaga aagagtaagc cactttacac gcgccttatc agcggaaaaa cgggcttttc 2106421 caaggtaaaa tcccattata acgccaatca aggcatggca tgaaacaggc agcagcgccc 2106481 tgacaaacgc atgctccacg ccgtggccaa ttaaataaag aatattttcg agggttgcaa 2106541 aaccgagtga tacacttgca ccgtacacaa tcccgtcata atgctcatca aagtgggcgt 2106601 gcgggtaaac actgatcatc agtataaacc attttaatga ttcctccaaa aaccccgaag 2106661 ataaaaaaga aacgaaaaag cttccgcctc ctacattctc tttttcaagt acatactgga 2106721 taaacatgat gggaaataca agaacaaccc cgagaaaaaa cgaccgtagc accatatgta 2106781 caggttcatt atcatactga tcttttaaat aaaaataact taataacgcg atgccggggg 2106841 caattcctgc agagatgatt gcaaacatca ggcaacctct ttcctttata ttcctacatc 2106901 tatcctacca tgttgtttaa aattttacat ctgtctgcac ttaaaaaaac aaaaagagca 2106961 tacgaatgca tcatatgctc ctcatcttta atggttttct cttttggcga tttccgctgc 2107021 gatatgcccc ccgtgaaacc tgccgttttc aataaatatt tcatttgcat tgtttcccgc 2107081 agcaataaca ccggcaataa agacaccttc aacgttcgtt tccatcgttt cttcgttgaa 2107141 aaatggacgc cctgtttctt tatcaatttc aacaccaatt ttttcaagaa attgatgatc 2107201 gggatgatag cctgtcatgg caaatacaaa atcattttta atggtaatga gttctttctc 2107261 tccggagcga aacacaactt cattctcggt gattttttcg acacaagctc caaattccat 2107321 acggattgta ccgtttctga cgagagcttc aaattccggc agaatccacg gcttaatgct 2107381 cggagaatac tcattgcccc tatataaaac tgtgacacgc gccccagatt tcacgagttc 2107441 aagggcggcg tccacgcttg aatttttccc gccgatgaca acaacatctt tatcaaaata 2107501 cgggtggcct tctttaaaat aatgaaatac tttcggcaaa tcctcaccgg gtacgcccat 2107561 atagtttgga tgatcataat agcctgtggc gatgatacaa tatggcgtcg tgtaggtctc 2107621 ttttgacgtc tcaataacga atgtgttatt ttgcgttttc gtcactttac gcaccatttc 2107681 aaacgcatta acacggatgt ttttccgttt aacgacttcc cggtaatacg ataaagcctg 2107741 aattctgaca ggcttcctgt tctctgtaat aaatgccaca tctccgattt cgagcttttc 2107801 acttgaactg aaaaaggttt gatgcgtcgg gtaattgtaa atactgttaa cgacattgcc 2107861 tttttcgatg acgagggcat caatgccaat ttgttttagg tgaatggcag cagatagtcc 2107921 acaaggtcct ccgcctataa taattgcttt ttcttgaatc atttctgtca actcctgcga 2107981 ttggcatttc acttcatatt ttctatttcc gaataaaaaa atctcctatt ttatcatagg 2108041 agatttttta tttttatgca aatcatcaac ttatatccag cctctaaaac gcgaagcttc 2108101 agccattttg cgaacgccga ccatatatgc agcgagcctc atgtcaattc ttcggttgtt 2108161 agccatttcg taaatattgt taaatgattt gaccatcatt ttttctaatt tttcttctac 2108221 ctcttcttca ctccagtaga agccttggtt attctgaacc cattcaaaat aagaaactgt 2108281 tacgccaccg gcacttgcca gcacgtctgg tacaagcaga atgtcccggt ctgaaagaat 2108341 ttttgttcct tcaagcgttg ttggtccgtt cgctgcttca acgacaattt tagcccggat 2108401 attatgggca ttttcttctg taatttgatt ttcaatcgca gcaggaacga gaatatcaca 2108461 atccagctcc agcagctctt ggttggtaat ggtatcgttg aaaagctttg ttacggtacc 2108521 gaagctgtcg cgtcggtcga gtaaataatc gatatcaagg ccttccggat cataaagtcc 2108581 gccatacgca tctgagatgc cgacaacttt tgcccccgca tcatgcataa attttgccaa 2108641 atagcttccc gcgtttccga agccttggac aacgacacgc gcacctttaa tatcgatgcc 2108701 tctcttctta gccgcttctt taatacagat ggtaacacct tttgctgtcg cagattctct 2108761 cccgtgagat ccgccaagca caagcggttt gcctgtaata aatccaggcg aattaaattc 2108821 atcaattctt gaatactcat ccatcatcca agccatgatt tgtgagtttg taaatacatc 2108881 cggtgccggc acgtcttttg tcgggccgac aatttggctg atcgctctga cataccctct 2108941 gctcagacgc tccagctctc taaacgacat atcccttgga tcacaaacaa ttccgccttt 2109001 accaccgcca tatggaagat caattatgcc gcattttaaa ctcatccaaa ttgaaagcgc 2109061 cttcaccgcc ttcacctctt tttctgttac gttcgggtga aaacgtatcc cgcctttcgt 2109121 tggaccgaca gagtcattgt gctgcgcacg atatcctgtg aaaatcttta ctgaaccgtc 2109181 gtccatacga acaggtattt ttaccgttaa taatctcatc ggctctttta acaattcgta 2109241 tacctcttcg ggatatccca atttttccag agccttatgt attacggttt gggttgattt 2109301 taatacatca agtttgtcct cttctgtatg accggtgttt cgatcggctg ccatttgagt 2109361 taacctccta gaatcttctg tttctcacat gctccctttc agagaatagt atacaccttc 2109421 atatgatctg tgcatagaat aaacgttatg tttttccatg ttttttaacg aaaaaaaact 2109481 gctgaaatca gcagttttcc gttgcattct tatgaaaaat gagtttgtat cgtttctacg 2109541 gcattaccgt ccataatgag cttaccatac tcttgcaggc gataaatcgt taaagttgtc 2109601 ggattgccgt attcagccag aaccgccaca accccttcag ccgtatgtga ccctagatct 2109661 tcaaggctta aaaagtactg cccgtcatag tggtagacag ttccccctgt gataccgatt 2109721 cgctgtaagc tttctgaaag ctgaatgata tcttcaaagg aatggaattg atatatgatg 2109781 tccgcgcttt catcaagctt gacttgcatt tcgatgtaat catcatcata ctcatcgtct 2109841 tctgaatcgg cgtcttggtt ctttgttaca atcacgacca tcccttgtgc ttggagagaa 2109901 tacacttcca ctgcaatcgg tccattcgct tcaaagccga gctctgtatt tgcttcattc 2109961 atcatatctt taaataactg gtggacttta aatgagtcct tccagaggtc ttcttttgtc 2110021 aatccccggt ctgtcaaatc atcgagggtt aaaaagattt tgatcttatt ataattcaga 2110081 cgctcaagcc gcataacgtt ccctcctgcc tctacttgca cacaaatcat ataacacatt 2110141 atatgagatg atgagtcata ggttcttaat tgttatcagt ttacactgag ttcactagta 2110201 agacaagcac aatgcagttt ttattgccat acggattttt gctttttaga agttattctg 2110261 gcccgcaaag agtcacaatg tgagtttcag gctcagcacc taaacgaaga ggcacttttg 2110321 tcgtgccgta gccgttgctg atcagatatg ccgcgttttt aacaatacct gttttcccca 2110381 gttcataagg accgaatttt ccaaacctga tctggcctcc atgggtatgt ccgctgagta 2110441 tcacatcaat accgtcatct tcattgattt gttcatgaat ctccggatta tggcaaacca 2110501 gaatattcag ctggctttca tcaagttctt tgatggcttc ctcataatga tccatctcca 2110561 tcctgatatc atcaaccccc gcaatcgcaa tcgtatgccc attgtatgaa aacgggactg 2110621 actcatttct cagagtgatg acgccgtgcg ctttaaatat ggaatacagc ttatgctgcc 2110681 tgacttcata atcattattc ccccacacaa acacgatagg gaccccgaaa tgtacgagcc 2110741 ttttgatgtt ttcctcgatt ctcgcactgg gcaccccgcc ctcagctaaa tcaccgccga 2110801 ttataaccaa gtggggggca tggcttcgcg ctttttctaa aaggtcttga tcgatgagac 2110861 gtttgtgaat gtctgaaata aaaaagattg tcagaggcgg cttgcccttc atctttgata 2110921 aaggaaacgt atgtgtcttc aaatgattgc cttttgctgt tgcatacatt tttgccgtca 2110981 ttgccgctgc cgcaacagtt agtacaccgg caattttcac tgatagcttc ataaaaaact 2111041 ctccattctt tttagaactt atcaataaga cggacaataa aaaaagacgt ttctatcgtt 2111101 tgagaaaacg ccccatttta tttactttca aaatatagat taatgtcata tttgtgcttc 2111161 atcatatgaa aaacagactc tctcgccttc catttatcgg gctgcggcca gagatcagtg 2111221 cttttctgaa taatttcaca tctcagttta tggaaatcag tctcggattt ttcttccttt 2111281 ttcttgaaat aatatgaagt gcagtaggca aaagcggttg ccagcatcca aaataaataa 2111341 aaggtatggc taagtatttc ttgaagtata agctgaggct ccgggctttt gatcatgatc 2111401 ataacacata ataagcctag gcagataagt gaagcccatc gccatctgcg gcattgtgct 2111461 gcataatttt cgaatttttg ttttcgtttt accagcgctt ggagcatctg tttggtcggc 2111521 gcgtctgtaa actgatccag ctgattccat aaggattcca tacgcttcac accttgtcca 2111581 ttttcattgc tacaatatat gaacgtaaaa taaaaataat accctattca tccattaaag 2111641 ggatgtccaa aacttgtccg gtgtaaacat catttccatt cagatgatta tatgctcgaa 2111701 ttttttcttc tcctgtccgg cttttataat acttcatgga aatgcggtat agcgtttctt 2111761 tcttttggac ggtgtgcttg acaacgcgat tcggcacatt ttgaactggc tcagctggct 2111821 gttcttgctg ttgtactgtt gattgggaag aggaagcagc cgcggcggtt gcttcctcct 2111881 tatttggcga gtcttctttt tccgctacag cagtctgttt cttatcagca gctgtttgct 2111941 cttttggctt ggaatcttct ggctcttttt ttgactcctt ctgcagtgcg gtttctttag 2112001 tgtctgcggt atcgttttta tcctctgatt tcgggacaac ctcatatttg ctttggctgc 2112061 tgtcaataaa aacatcttca taatcgtcat gattatccgg gtggctcttt agataaaata 2112121 aggtgactaa aacgataacc ggcacaaata caaatattac tgcgagtact gtgaataatg 2112181 gcgtttttgt tttgccttgc ttttttttct gttctctttg attttttaca gattgtcttg 2112241 tcggaaggct ttctccatca tcgacataat cgtccgccaa tgcggcgttt tgatcttcat 2112301 aaagattctg ggcttttctt ctctctactc tcgacatgtt cgtcatgttt atccctcctc 2112361 acatgttcaa aacgaatctg acaggcaaac acggcatcaa tgataaaatg cgccgtcatc 2112421 ggaacaaata agttgccggt ccattcatac atcagaccga gcaaaaagct gattgctgtc 2112481 accataataa ataacagcca ttttgacaaa taccgaaagt gcagagcggc aaatataagg 2112541 ctggccgtcc ataaaccgat atgagtctgc agcactcctc tgaataacat ttcttccgcg 2112601 aaagcaatca gaagcgttaa aaatataata tgagggattg acctcttact gaatattttt 2112661 ttattgattc cgccgtcatc atataaatga gacggaaacc atttcattac tgccatatcg 2112721 gctaaaataa caataacagc tatagaaaca ccataccaga tgattcgcat atcgcgaatg 2112781 tcccagagct ttaatacgtc ccgtacatcc tcaaaaaaga acagtcctgc tgcagcagcg 2112841 gcaaagatga tgagtagctg cgtcaaatat aactgcttca gcatatcatg gtcagtcata 2112901 tgctgaatat aatctttttg ctgtttcagt tcagctcacc tacagtctgc aagctgaata 2112961 tccggtgcaa ttccgaactc cagctgtcta atggcgccat tttactccgt tccccttttt 2113021 gttcatacaa ggataaatca aaaccgcaat gtgaacagca cgggaggttt ccgtcatcag 2113081 gctcgtatga ttcatcaaag taggttaaca gtgcctgcct taaacagccg tcacgctgaa 2113141 gcaaaaatga tacacggtgc attttttcca gcttcagctc catgcgatat gaaatttctt 2113201 tcttcatcag ttcaactgat gtttttccct gcataaagag atgaatcatc atacgggcct 2113261 gtgtctctcc gacgccatac tgaagtaata cgtcacgcag ccttctctca tcccgctcct 2113321 ccgtcttctc tagcacacgg attacgtcgg cgatttcttc agctgtgaca ctctccatct 2113381 ggataatttg ttcctgcaat tcaaaatccc ctggcgcccg cagcaaaatg ctgacactcg 2113441 gctttccgtc gcgtcccgct ctgccgattt cctgcataaa agcttctgcc gtctgcggga 2113501 gatgaaaatg aatcacatat ctgatatcag gtttatcgac acccattcca aacgcattcg 2113561 tacaacatat cacatcaagc tggttatgaa taaactgctg ctgaattaaa atcctgtccc 2113621 ctgactccaa accgccatgg taaaagtcgg ctctgctgct cgttttgctt ttaatttcac 2113681 ccgctaattc cttagcccat ttccgtgttg gacaataaac aattcccgga ccttgcaggt 2113741 tttcaaccag ctgaatgacc ctatctattt tttcggcagt atccgccgca ttttcaaccc 2113801 tcagtgcgat gtttgggcgg ttgactgagt tgagatggcg tacagcatgc tgcagctcca 2113861 gcaggttcat gacatcttgc agcgtttcct ttgtagccgt ggcggtcaat gccagaacgg 2113921 gtgggtgtcc aagttttttt ctcagctgtc cgagctttga ataatcaggc ctgaagtcgt 2113981 gtccccattc agaaatacaa tgcgcttcgt caataacaaa taggctaatc ggaacgcttt 2114041 tcaatttttc caatacatat ggagactgta aagcttcagg agacaagtac aaaaatttat 2114101 atcgatgaat atgttctaaa acaaattgtc tttcctgcct gttaagcatg ctgttcaaag 2114161 ctgcagcacg cttttccccc cgggctttga gctgctgcac ctgatcctcc attaaagaaa 2114221 gcagtggaga aacgattaat accatgccat caagcatata accaggcagc tggtagcaaa 2114281 gcgatttccc tcccccagtc gggagcattg caatggtatc cttcccgctg agtatgcttt 2114341 caataatgtc ctgctgccct tttttaaagg aagtaaaacc aaaaaactga tataacgttt 2114401 gctgtaattt agtcatattg ctgcacctgc tttgtcaatg ccagtctgat ttgaaagtag 2114461 ctgaaccgct gttccagccc gtcgcgaatt tgtttgattt tattcgtccg catccgtttg 2114521 gcaaactctg cgatttgaag ctggtcttct gctgatacat agtcattaat cataaacgca 2114581 ggctcatgga gagaaatctc gacaatgtgg tcttcaatcg tcgctgtttt cagctttctg 2114641 atttcagcaa ttcgctgtat cggaaaccct tgtttgacca tctgccatgt tttcctcgtc 2114701 gactctgtca gggcattatc taagtgcaca tcagaaagga gatcctttaa caaagcatct 2114761 tcacactccg gaagagaatg aataaaataa tgtaccgaag cccaaaacat gatatagaca 2114821 taccattcgt cttctttcag cgtatcagca agctgcctgc tcgtataacc gatccgatgg 2114881 tgcgaggtta aggagtagac aaaaatttgc gctgctttgt tttcaatctt tttcaaatgc 2114941 gcctcaagca tggcaaaaag gctttttgcc atctctatat gatccgtatg ccgggacagg 2115001 tatttcttta cccagtgaag tgtcttatga tcctttgtga cagggatata ctgcctgctc 2115061 ccttgctgtt tatgggatag gacctgcaca agcagcgaaa gccttttcca aagcacgccg 2115121 gcagcctgct gataatgagc gccgtgacaa tgaacgggcc aaggccgctc gctaagggca 2115181 tgtctcaaaa ctgctgcgcc gctggctgtc actttgtatg tatctgattc agacattggc 2115241 gcgagatatg aatgcttttc aagcttgtca agcgacgcag aaatatcgct tctcgaacat 2115301 tttgccgcca ttccaaagta ttttgcagtc tgaaataagc cggcatcttg aatggtctgt 2115361 gacgatctct tgcctttgaa taggtgaaaa acagcgcttc ccgaccgttc cccgtttatt 2115421 ttgcaaagac aatcgagaac cataatatcg aagtaattta atgacaacct atccacctac 2115481 attcttcctg acaaaaatcg ttgatttgct ctttttattt taacagattt caaacagaaa 2115541 tcgacgttta aagtcatcat taagggggat gttatgtaga taacccctta tgtgataagc 2115601 attctcaatc atttttctgt tgaaatgtgg cagcaacatc attacaataa gtaagaggaa 2115661 taggtgttaa attgattaaa tataaagatt gatccatttg ttccaccaag aacaatctgg 2115721 gaggttttat tcatggcaaa gtacacaatc gtagacaaag atacatgtat tgcatgcggc 2115781 gcttgcggag ctgctgcacc agacatttac gattacgatg atgaaggcat cgcgttcgta 2115841 acgcttgatg aaaacaaagg tgttgtcgaa gttcctgagg tactggaaga agatatgatt 2115901 gacgcatttg aaggatgccc tactgattcc atcaaagtgg cggatgagcc atttgaaggc 2115961 gacccgctta aatttgaata gaagtaacta aaaaaagctc ccgaacggga gcttttttat 2116021 ttaatggata tgtgcacttc gctgctgctc aatccatggc ttaagcttga taaaaattag 2116081 tgagaataca accgtaatta caataccttt tatcatgtta aacggcagga tacctgcgac 2116141 gactgctgtt tttagcgcgc tgtcggataa tgccggtgaa tgtaaaaacc acgtgtatgc 2116201 cggaagaatc agaacataat ttaaaatact cattaaaatg gtcatcgctg cagttcccaa 2116261 aagcaggctg acagccaagc cctttgctga gttgagtttt ttaaataaga aagcagtcgg 2116321 taatataaag agtgttcctg caataaaatt cgcaacttgc cctacaggaa ctccggccat 2116381 gcttccctga atgatatact gaagaacatt ttttatcgct tctacggcaa tacccgccaa 2116441 aggtccgtaa atcagaatgg caataattgc gggaacgtcg ctaaaatcga tttttaaata 2116501 atccggaaga cccggaaacg ggaaatttaa cagcatcaaa acaaatgcaa tgctgctcag 2116561 catgctgacc acaactaatt tttttacttt cacttcattc tctccttttc gatcacatct 2116621 tactcgaaaa cggaaaggtt cttttccagc caataaaaaa accgcttcat atataaaagc 2116681 ggggtttcga aaattaggct aggcaaagaa acgtttgaaa aattcaattt caaaacgctt 2116741 atgaacctcc atcttctccc atccagactg tactgtcggc tccggaatct caccgaatcc 2116801 tgctgtaaag acagctcgcg ggcttagagc cattggctca tcaccgccgg tagggaattt 2116861 caccctgccc cgaagattga tcatatgaaa tttaattaca ttataaacga taactggttg 2116921 gctgtataga gaattgcttc aaattaaata tattacctgc aagctgtcag atcattgatt 2116981 tattaggctt tacttttatc ctttactgcg tcaatacacg ttgacactct tttgagaata 2117041 tgttaaatta tcagatattt agtttgtcaa tttaggagga aatctaacga tgtttcgagt 2117101 attggtctca gacaaaatga gcaacgacgg tttacagcca cttattgaat cagactttat 2117161 tgaaatcgtt caaaaaaacg tagcagatgc agaagatgaa ttacatactt ttgatgctct 2117221 tttggtgcga agcgcgacaa aagtaacaga agaccttttc aacaaaatga cttctttaaa 2117281 aattgtcgga agagccggtg tcggtgtcga taatatcgat attgatgagg ctacgaaaca 2117341 cggggtaatc gtgatcaatg ctccgaacgg caacaccatt tcgacagctg agcatacatt 2117401 tgcaatgatc tcttctttaa tgagacacat tccgcaggct aatatctcag tgaaatccag 2117461 agagtggaac cgcacagctt atgtcggttc agagctttat ggaaaaacgc ttggtattgt 2117521 aggattaggc cgaatcggaa gtgaaattgc acagcgtgcg agagcgttcg gtatgactgt 2117581 gcacgttttt gatcctttct taacggaaga aagagcgaaa aaaatcggcg taaacagccg 2117641 tacatttgaa gaagtgcttg aaagtgcgga tatcattacc gttcacacgc ctttaacaaa 2117701 agaaacaaaa ggcttattga ataaagaaac gattgcaaaa acgaaaaaag gcgttcgctt 2117761 aattaactgt gcgcgaggcg gaattatcga tgaagcagca cttctcgaag ctttggaaaa 2117821 cgggcatgtt gcgggagcag cgcttgacgt tttcgaagtc gaaccgccag ttgacaacaa 2117881 acttgttgat catccattag tcattgccac tcctcacttg ggagcatcaa cgaaagaagc 2117941 acagctcaat gtcgccgccc aagtgtcaga agaagttctg cagttcgcaa aaggcctgcc 2118001 tgtcatgtca gctatcaacc tgcctgccat gacaaaagat gaatttgcta aaattaagcc 2118061 ttaccatcaa attgcaggaa aaattggcag ccttgtatca cagtgcatga aagaaccagt 2118121 acaggatgtt gccattcaat atgaaggcac aattgctaaa cttgaaacat cgttcattac 2118181 aaaagccctt ctgtcaggct ttttaaaacc gcgcgtagac tctactgtta atgaggtcaa 2118241 tgccgggggt gtcgcaaaag aacgcggcat tagcttcagt gaaaaaattt cctcttctga 2118301 atctggatac gataactgca tcagcgtaaa agtgacagga gaccgcagca cctttactgt 2118361 aacggctacg tatattcctc atttcggaga acgaattgtc gagatcaatg gatttaatat 2118421 tgatttttat ccgactggtc acttggtgta tatccagcat caagatacaa caggtgtcat 2118481 cggccgagta ggacgtattc tcggagataa tgatattaac attgcaacta tgcaggttgg 2118541 ccgtaaggaa aaaggcggag aagccatcat gatgctttcc tttgacagac atctggaaga 2118601 taaaattgtg aaagaactaa caaatgtccc tgatattgtg tctgtgaagc tcattgatct 2118661 gccataatta aaaaaactca agctatatag cttgagtttt tttattgttc tatccccgtg 2118721 tgtttttatg caaaatatct aagacactcc ttagctcaga aacaggaatt tggcctggtg 2118781 cggacgcctc ttctccagct ccaaaagtac aagccgatcc aaaaacctca ccgctcagcc 2118841 tgctgatgag ccctgttgca gccattgaca ttgtaataat ggggcggtct gcatatattg 2118901 ttttcattgt atacgtcgca tcaagcagtg ttaggagatc tccagtatca ttcggcatga 2118961 cagccatttt tggaatatgc gcgcctaagt cctgcatttt tcgaagtctg gaaataattt 2119021 catcttttac aggtgttttt tcaaagtcgt gatttgacat caccacatag acgttgtttt 2119081 cttccgccag cgatactaac gcttttacat ttgcatctcc tgaaaataat tcgatgtcta 2119141 tcagatcgat gtcttttgtt tggattgccg attccagcaa agcaagatag gagctttcgt 2119201 ccatctccat gctcccgccc tctttgtggg ttctgaatgt aaatagaaat agcttgtctt 2119261 ctaaagattt acgaagctta gaaatgagct ttgtgaccgc ttctctgtca ttcgcttttt 2119321 caaatacgtc gactctccat tcaacaatgt ccggattcag taattttact gcctctgctt 2119381 cattcagaat ttgtttttcc gtctttccca tcagcggaat gatgattttc ggcatccctt 2119441 ccccgatgga aactccttta atcgttaaca cgttcactcg tctcaaatcc tttcaatctt 2119501 taccttgttt tattatacac gtacaacttt tttttgaaaa tttctattat atgaatagca 2119561 actaaaaaag agccttaaag ggctcttttt agtttaagga aatcggattt ggagcagctg 2119621 gcaccggaat tgcatctgat atgtcatatt tgccgatttt tttcgttctg gtttccgtaa 2119681 aggtcacttc tgtgaagcca aactcttttg cagtcaaaag tagtccctca atcattaaaa 2119741 taccggcaat agaatcatca acttctgact cctttgaaaa gcggatatat aagtgtttct 2119801 gtttcttcgt tacagattgg acagcacccg cttgaataag aggtgtcgta tcttcttggc 2119861 tgctcgattc catttcctta atcgcttctt ttactgtatc aaaagaatga tttgacggaa 2119921 cgagaaagtc ttgtccttgt ttattttggt acaagtagta ggatcgtttt gactgtttgg 2119981 gaatcgaaat ttccgtaaaa gtgccatatg agccaatccg aaccccagtc tcattttgat 2120041 ccgataaaaa tttgactttt tcataaggac tccattttaa ggattcttta agcaattttt 2120101 ttaacagtgt atcatctttt atagaaaatg ccgtagctgg ctgatggact cgtatactta 2120161 attccttctg ctttggtttt tcctttattt ctacttcatc tatgaaggtt ggaattgtaa 2120221 tggcatgatc aaggatgccc aattcactac tttcaaacag catatcctgg atcgtttggt 2120281 ctgcatttgt tttttgaatg ctgacgggta tgattgcaga tgtatcggca tcagcaaccg 2120341 ctacagtgat gtaattgtct tgttcctttt caggaacgac aaacgatgtc tgatccaagg 2120401 acgatgcagc ttttgggctg tcttctgtct cagttttcgt tactgcgttc tcttgggacg 2120461 cttctttttg ttgaggctgt gcctgatcaa agaaatgagg agaaataatg aaggcgatat 2120521 aaaccgcaat tgcagcggca cacgcggggc caatccacct gacagcgggc ttatttttac 2120581 gctttgccat cgtcagccgc ttgtaaatat cctgaggcga acgatggtct ttaactgccg 2120641 gaagttgact taacaactcc tttatctgtt cttcgttcca ttctgacttc atcatccatt 2120701 agctcctccc tcaaaagctc catatgtttc cgaagtactt tgagccctct gtgttgggtc 2120761 gtttttactt tgctttccga gaagcgcaga gccttggctg tttcctgtat tgaatatccc 2120821 tgaataaacc gcaagataat cacagctctt tgatcgattg tacattgatc aagcgcagca 2120881 taaatttccc ggacattttc atgttgaacc gcaagttcgt ccggcagcaa ttgctgatcc 2120941 ctgacatcct gtgtatccca gtcaaatgta ccgagtatac gctgtctgat tgtttgctgt 2121001 ttacggaacc agtctatcgc aacatggcgt gcgatagaca aaagccatgt tttttcactg 2121061 cttcttcctt caaacgtatg ataagaattt aatacccgga tataaacctc ttgaagaagg 2121121 tcttctgtct ggtttttatc ctttaccata taaaataaaa attggtacaa atcttgatga 2121181 tatgtatcat ataataattg aaaggtttct tccatttgaa acccctccgt tcactttttt 2121241 gtcgtatgaa tagcttgaaa agttacatta caactatatt acgagtaact ggaatttgga 2121301 agggaattta tattaacata tccttaaatt ttattaatgt tggctattaa aaaaacaccc 2121361 gctcagtcag cgggtgtttc ttatggaaca agattcttcg gcaaattcag actcgatttt 2121421 accgttttgt cggaatataa aaagaaaatg ttgttccttt atctattcgg ctgtgcacag 2121481 taattgatcc gttgtgggct tccacgatat ttttaacgat agccagccct aacccggttc 2121541 ctgctctgcc ccttgtccgc gctttatctg ccttataaaa ccgctcaaag ataaatggca 2121601 gatcttcttc cggtatgcca gacccggagt ctttgatatc aattttcaat ccatccttca 2121661 cagaatggac tgaaatggag acactgccgc cggctgaagt atgccgcagc gcgttatcaa 2121721 tcaaattggt aaatacctgc tccatcttgt cttcatcaaa cataaattcc tcttctgtga 2121781 gagaaatgtc atgatctaaa gcaatatttt tttctttcgc aacaccggaa aacttccgaa 2121841 tgatcttttc taaaaactca ttcacattga ttttttcata atgtaagcct gtatggcctg 2121901 attccattcg ggctaaatca agcaaatcat taactaaacg gcccattcgg agcgattcgt 2121961 cataaatgat ttgggcaatt tctttccggt cttcttcaga gcttgcaatg tcatcgacaa 2122021 ttgcttcact gtatccctga agcatggaga tcggtgttct cagctcatga ctgacatttg 2122081 cgataaagtc ctcccgcagc ttatcaaggc ggcgttcttc tgtcatgtca cgcagtacgg 2122141 caaccgctcc tctgacgtgc gattccgcat aaagcggcga catcaaaagc acccatgatc 2122201 tgccttgaag cgtcatctca atcatttgtt ctttttcagt gctgacagcg ttttgaaaca 2122261 gctcttttgc ttcaggcgga agattgtcgc cttctttgat attcatgttc tgttcataat 2122321 accaagcctg aagaaaacgt tcagccggcg ggttggtcac aagaatcgta ccgtcaatat 2122381 taatggtaat aaccccgtca gccatactgc tcaaaatgtt agaaagctgc tctttttctt 2122441 gattgagcgc attgatatga aagttaagct gccggcccat ttgattaaaa gcggtcgcca 2122501 gttcaccgat ttcatcctga gttaaaatcg ggatttttgt atcgaacttg cccttcgcca 2122561 aatcctgcgc gccttctctc atttttcgga gagggtacgt gaccctgctt gataaaaaga 2122621 atgcgaaaaa tgtggtcagc acaatcgcaa ttccagcggc aagaaaaata tagcgggtcg 2122681 tatgttttgt tgtatcttta acggcaagca aagactggga taaaaagacc atgcctttct 2122741 ttccgtcttt ttcatacggg acacctacaa tcaggcgttc attatccgtg tctgtatcgc 2122801 tcagtcccgt ccgtttgctt acttttttat ggtctttgag agctttattt aagtctttgt 2122861 catgctgtat ttgctcaacc gtaatagacg acaggcgatt tttatcattc ggagaatacc 2122921 agtggttctt ctcatcctgg atgatggcaa tgcttgttaa gttatcagcg agttcccaag 2122981 tgattgacct tgccagtgcc tggtcctcgt gattttctag gatgacagca actttattcg 2123041 caagctgtgt taaatcattc tcagcttctt ccacatggta gttttcaata aactccagca 2123101 aaagaaccgt taaaatgaac aatacgatca agacgagtga aaggatcgta aaccacagct 2123161 tgcctactac gcttttccaa aatttcattc agcgccgacc tcaaatttat aacctacacc 2123221 ccatacggtg acaatttttt tcgcagcttc cggagatacc ttgttcagct tctctctcaa 2123281 gcgtttgacg tgagtgtcca ctgtccgtaa atcaccaaaa aactcatatt gccacacttc 2123341 tttcagaagc ttttcccgat catacacctt gtcaggcgtt ttcgctaaga aatatagaag 2123401 ctcatactct tttggcgtca ggctcacttc tgttccatca gctgttacgc ggtgagcatc 2123461 atggtctatt gacagatgtg aaaacacgag cacatttttc gtcggtgtat tggcattgaa 2123521 ataagaggtt tgggatgctc ttctcaaaag ggcctttaca cgcagcacga cttctctcgg 2123581 gctgaacggc ttaacaatat aatcatctgt tcccgcttca aacccctgca cccggtttgc 2123641 ttcttctcct tttgcggtca gcataataat gggtgtcgct tttttttcac gaatttgccg 2123701 gcacacttca attccatcag tccccggcat catcagatca agcaaaatta agtcataatt 2123761 ggcttcaagc cctttggcaa tggcttcatc accattttca gcttcatcta tagcataatt 2123821 ttcacgttca agatacattc ttaaaaggcg gcgaattctg gcttcgtcat caactactaa 2123881 tatttttgtt tcgttcgttt ggtccatgtt ttccccctgc tttccttctg ttactttcat 2123941 tttatcaaat cgtgagaaag tttgagaact gtgtcgcttt caaaggacta tgcataagaa 2124001 tgaagtccgg caagcacaag atttacgaat attaaattaa acataataat agcaaaaccg 2124061 attacggcca gccatgctga cttctcaccg tgccagcctc ttgacagtct taaatgcaag 2124121 taagcggcat agaacaaaaa tgtgatcagc gcccatactt ccttagggtc ccagccccaa 2124181 aatctggtcc acgcgagctg agcccaaatc attgcaaaga tcagcgcgcc gagtgtaaag 2124241 atcggaaatc cgattgatac ggccctgtac ccaacctcat ccaccagatc aagattgacg 2124301 tttttcacca gcggatgtaa tagagcgctg attctttttc tgatgatcag acggagagcc 2124361 ccatacaaca caagacctgc tccaaatgac caaatgacag tgttcacttt tctgcctgag 2124421 aaaagcgcgg gaagatcaac aagcggttcc attcttcctt cggtcaaaag ctctccctga 2124481 tgcggaccga caagcgcggg catttcgtac accatcacgc ttttttcttt acttttgtcc 2124541 acccagttaa actccgcttc atagcctgca agacgaaatg ccgatgtgat tgcaataaag 2124601 gcgacggttg tgaccaggat aaacataatc gcttcaagcc agaaggtctt tttgcttggc 2124661 tttgtctggt ctacatgctt caaaagaaag atgacaccag cgacaaagct gatggcaagt 2124721 atagcttgcc caagcgcggc cgttgttacg tgaatataca gccagttact ttggagcgaa 2124781 ggaattaaag gcgagatatc tgtcggaaac atgctggcgt aggcaatcag caataaagca 2124841 attgacagcg taaacaggcc taatgaaggc aatctataga gaaaataaag aatgataaac 2124901 gccaaaacaa gcatcatgcc aaaagcggtg gtgaattcaa acatattgct gacaggcgca 2124961 tggccgcttg cagcccacct tgtgatgaaa tatcctaggt ggcagaaaaa accgacaata 2125021 gaaagggtga ttccaatgtt ggcccatcgg tttggcctgc cctttttatc tttattcccg 2125081 cgtatggccc cgccgaagat tgggacagcg attaaataca caagaaaggc cgcataaaga 2125141 aaatttccgc tcagctctgc catgacatca ctcccttttc gcctatttct gtgttttgat 2125201 taattctttt tggtccaccg gttcagtcag tccggaatca gccaatataa atgctaaatc 2125261 cttcttcagg ccaaaccagt ttttattggt atgccctgct accataactg caccgtcctg 2125321 tgagtgcagc caaattcttc gatgctgcca gtacatacct tgaatgacac cgatcataaa 2125381 aatggctccg ccgacagcaa gcacccagag tgtcagatcc tttctgactg taagtccagt 2125441 aatgtttttc gtttcgacat ggtcaaattt cagcttgtat ttattattgc ctgatccttc 2125501 gatggtttct tggatggcga caaagctctt ttcgcctttc ggtttgtccg gcgttatgat 2125561 attaaagaca aaagccggat tgttagggat ctttgttttt gtgctcggct ctccgtcctg 2125621 attaaaatag aagtcaggca ggtagctggc gatttccacc ttgtaaccgt taccaagatc 2125681 atagactgaa tctggatcca gaaggttgat cttcaggctc ccaaaggatt tttttgtttt 2125741 tttatcaatc agctggaaca ccatttggtc aagctgattc tctttgtaat ccacctggta 2125801 aacggaaaaa gaatcaaaac gcagcggctg attgacacgg atgtcttctt ctgttacttt 2125861 ttccagcttc ggcttctcgc cataaacaat ttttccttct ctcttgtaga gtacggcatc 2125921 agtttgaaag ttctttgcca ctctaccgtc cccgactctg tcaatggcat ctgcaaatac 2125981 ctttttttcc gttttgctgt tataggtctc tacgctgaat tgattgtttt tcaaataata 2126041 ttttccgtct gtacccggaa ttgctgcggt ttcgccttct ctgacccaaa gcgtctcatc 2126101 gacgtacatg ccaggcacaa atctcagcat cgcaccaatc agaaagatga tcaatccaat 2126161 gtggttgaca tacgggcccc agcgggaaaa gcgtcctttt tcagcaagaa tgctgccctc 2126221 tttttctctg attctataat gttttttctt taatagagta actatctttt ctttcgattc 2126281 cccgttcagt acagtaactg tttcactgaa caagcgctgc cttcttaaaa aggccgggct 2126341 ccttctgaca ccttggtttt ttaacgctct atacaacgga atgacccgat caaggctgca 2126401 aatcacgagt gaaatgccga tcgaggcaat gagcagcaaa taccaccaag aaccatataa 2126461 atgatgaaac ccgagcaaat aataaagctg gccaaacgtg ccgtactgct ccttgtaata 2126521 agtatcagcc tgtgcgcccg gaggcagata ggcttcctgg ggaaaaatgg tgccgaacgc 2126581 tgatgcggca agggttatga cgataagcca tattcccacc ttaaccgagg aaaagaaatt 2126641 ccaaattttg tcgatgatcg ttttgttata ggtttgcgaa cgtcttgcgc ttccgtcata 2126701 tctcatatca gcgagcggag gttgagtttc ctgaagagct cttccgcacg attcgcataa 2126761 aacggttccg accgggttta tatgtccgca ttcacatttg acttgcttca tcccgaagtc 2126821 tctccgggtt ttatgagatt catataatcg tgtatcatgc tttctgtcat agtgccggtc 2126881 accaccttga caacttttcc ttccggattg atcaaaaagg ttgtcggaag cggagatacg 2126941 tcataggcat caagcacttg gcgatctgta tccagaacaa ccgggaaatt gactccgtag 2127001 gatttcataa aattatgtac tgctatcttt gactccccaa catttacagc gacaatttca 2127061 acaccttggc ttttaaaatg cttatattgg tttgccatat aaggaaactc ttttttgcac 2127121 ggttcacacc atgtacccca gaaattcaaa aaaacacctt tcccttttaa gtcactgagc 2127181 tcgatacgtt tcccattcgt atcctctagg acaaaattcg gtgcgtcgga cccttcggat 2127241 atactctctt tgccggcaaa tacagcgttg taaatggtat agccgagtgc gcagattaaa 2127301 acgagaagga tgccggtccg aatgaataaa cgcctttttt tcttcattgt ccactgcccc 2127361 cttcccccta ttgcagatcc attcaattat atcattgcac gttcatttca catttcttac 2127421 tttttgaagg ttatgtgaaa tttagaaagc gtttttaccg tgatccgcca gtgctctgag 2127481 cctttttact tcgtgaggcg taagctctct ggcatcgccc gtgtgcaggc ctcgcaggtt 2127541 taaaaacgcg tattcctcac gcttcagctt gattacctca tgtccgatcg cttcaaacat 2127601 gcggcgcact tgtctgttgc gtccctcatg gatcgtcagc tgaataatgc ttgtctgctt 2127661 tttcttatcc aaagacagca gcttcgcttt agcaggcgct gttttgcctt cctccagcct 2127721 aattccgcgc tccagctttc tgagcagctc tttaggcggg attcctttca ccttcgccac 2127781 gtatgttttg tctatttcat acttaggatg cattagctta ttggcgaatt cgccgtcatt 2127841 ggttaaaagc aaaagaccgc tcgtatcata gtccagacgc ccaatcggat aaatgcgctg 2127901 cggaatattt ttaaaaaagt ccgtcaccac tttgcgtcct ttatcatctt gcgctgcgga 2127961 aataacgcct cttggtttat ataagagaaa gtaaaccggc tcttcgcgtt caacctttaa 2128021 cccgtttacc tcaatctgat cagaaccggt gaccttaaca cctagctctg ttactacttt 2128081 gccattcacc tttacttttc cttctttaat cagctcttct gcctttctgc gcgacgcaac 2128141 tccggcatga gcaatcactt tttgcagtct ttccatgtct ttcacctcaa gtattatctt 2128201 acttttttca accttaacaa acaagctttt tcaaattcct atgccaaatc taaaaaaaac 2128261 gccgttttca ggcgctccca aataataacg taacgatgat gatagatgca actacgccga 2128321 ttaaatctgc aagaagtccc acctttaatg catcacccat ttttttaatg ccgactgctc 2128381 cgaaatacac agtcagtacg taaagcgttg tatctgtaga tccctgcatg acggaagcca 2128441 gcctgccgat aaaggaatcg ggcccgtata ctgcaattaa atcggtcgtc attccaagtg 2128501 cggccgtacc ggagatcggg cggatcagag caagcggcac tacttcagca gggatgccga 2128561 tagcggagaa agccggtttt aaaagatcca ttataaaatc aagcgcgcct gatgatctga 2128621 aaacagttat agcgacaagc attccgacta aataggggat aatggaaaag gcaatttcta 2128681 tcccctcttt cccgccttcg acaaacgatt catatgtcgg aacctttttg atcgttccat 2128741 aaagaagaat tccggcaata atgattggaa tcatggctaa agacagccag ttgatgattt 2128801 ccatccgctc accttccctt ctttttgcgg cggtaataaa aataccgatc aatgataatg 2128861 gcaccgattc cggaaataag cgttgccaaa atgcttggcc cgacgatatc tgtcggcgtt 2128921 ttggaggaat aagccattcg gacagcgatc accgttgtcg ggatgagtgt gatgcaggac 2128981 gtattaacag ctaaaaaagt aatcatcgac cggcttgctt ccgatcggtt tccgttcagc 2129041 tttttcattt gttccattgc tttaatgcca agcggagttg ctgcatttcc gaggccgaag 2129101 aaattcgcca taagattaga taaaatatag cccatcgccg ggtgatccgg cggtatatca 2129161 gggaacagtt tagatataaa aggtctgcac atccggctga aaatatccaa aagccctgac 2129221 tgctcggcga ttttcattaa gccaagccag aaaacaagca cgctcatcaa tccaaatgag 2129281 atcgtaatcg cttctttcgc acccttaaac acggcttcat ttacatcttg cagagttccg 2129341 ttgcacatcg caaaaacgag tccgatcacg gttaaactga cccaaattat attgaccatt 2129401 ttgctccgcc tgccgcattc agaaagattg atttaaacgt ttcaaaaaat tgtttcttcg 2129461 gtttttgatg ccgctcattt tcataataga tcggcacttt tgcgatggtt gcatcgttga 2129521 acatgatctc catgtgccct acgatgtcag ggattttcga ggcatctttt tcccatgctt 2129581 ttttcggctt gagcagtgtg gtattaattt ttacattttc tttttcctct tcggtcagca 2129641 aataggtgat atcacgtttg ataaaagcct tcgattcata aaatgtgcct ttcagctttg 2129701 gaatatcccc tttttttgca attaaatagg tttgataatg ctcaaacaca tagttaaaca 2129761 tcttcatatg gtcatcccaa tcattagggt cattaatggt gacggctatc aggtcaatgc 2129821 cgtcctttga agccgtagag accagtgtcc gttttgcaag ttttgtatag cctgtttttc 2129881 ctcctgtgct gtacggataa agcatggtca gcagtttgtt tttgtttttc catacgcttt 2129941 ccatcgtttc cgctttgtat atttttgtgc ctgaaatctt ttgatagtct ttcagcttca 2130001 tagcatactt agttaaaatg gccatgtcat aggctgttga ataatgattt tcatggtcgt 2130061 ccaatccgtg cgggttttga aaacgggtgt ttttcatacc aagctgctcg gctttttgat 2130121 tcatcatata aacaaaccca tcgaggctcc caccgacatg ctcagcaatc gcgacagcgg 2130181 catcgtttcc tgatcttagc atcaggccat acacaagatc tttcagcttc actttttgac 2130241 cttctgttaa ataaatggcg gagccttctg ttctgacagc atttgccgaa accgtcactg 2130301 tttgatccat tttgccggat tcgatggcga ggacggcggt cataattttt gtgatgctcg 2130361 cgatccgcct tttttgatgc tcatccttgg catataacac tctgcctgac gcaccgtcaa 2130421 taatgatcgc gctttttgca ctgacatcta tagcagcatg tgctgtattc acatttacgg 2130481 ttgcaataag aaaagaaatc atgatcacga atactgcttt tttgaaaatg cgcatgtttg 2130541 ctcacgtcct tgtggtggtt tgtacaagtt tatgcgcatg tccatcagtt atgaataaca 2130601 attatatttc tggaagcaaa cataaaaaaa ctctccctga aaaagggaga gtaaacgtta 2130661 tctgattggc gccatgcttg atccggacgc ttcgtaatga gccagctctt ccctcatctt 2130721 cagaaaggcc gcgctcaacg gcaataataa ttgctcaagc gacgcaggaa cagcatgata 2130781 aaactcaatt gcgctgaccc cggtataaga cgcccggcta ttttcacacc acgtgtcttt 2130841 tttcggcata aagaactctt caatgcattg gtgatacaca ttataaagtg ttttttccgc 2130901 tctggcttcc tgaaaaggct cctgcatcag gagacgacgg cacgcttctg cgcctccttc 2130961 acaaaatact gccattcttc tcagagtgct aagcacatca cagcagtatc ctttttcaat 2131021 aggcaattca gcctgtaagg actcaagcgt cgtttgattt aggtaatcgt tcacggtatt 2131081 gacaaccatt gataagaatt cgcctgtttt ttgagtctgc gctcgcacaa tcgaatgtcc 2131141 catttcgttt ggtatcttcc cctcatgtat ttgtctctca cattttgctt ctttcatgat 2131201 agcttcttcc ttatatctta tgatgatgaa aaagcgcgat tcattaaact tctattttat 2131261 atcttcgaag gtttggttaa agttttcaaa aaataaatct gcttcttctt gaagaacgtc 2131321 ttcttccgca ttttcaggca gcggcggaag ctcgtccagc gttttcagac cgaattgttc 2131381 aagaaaagtc ggcgtagtac cgtataaaat ggcccgcccc ggaccatcgg cacgccctac 2131441 ttcacacaat agcgccttcg cgacaagact gtgtaaaatc cgctctgatt ttactcctct 2131501 gatttcttca atttctgctc tcgtaattgg ctgtttgtat gaaacaatgg ccagtacttc 2131561 taaagatgct tgagaaaggc cctttgacgg cacttcaatc agttttttca agtaaggcgc 2131621 aaagtctttt ttggtagaga gcatgtacgt atctgcatac tcaataagtt caatccctcg 2131681 tgtatctccg cggtattcgt ccgccacatc cgccatgatc gtgttcagtt caggctcttc 2131741 gatttcaagc actgttaaca gctgcttttt tgtaagccct tcatcgcctg ccgcataaag 2131801 aagggcttcc acaatagctt tccaattcac gatatcaagc cccatgaatg gattcactcc 2131861 ccgtaatgta aatatctgaa aaattgtgct cctgttcaat gaggaccagc tgatttttca 2131921 tcagctcaag aacagctaga aaggtcacta ctaaatgttc tttttgctca tatggaaaca 2131981 gatccataaa gttaattctc gttcctctag atttcaagct gtgcacgatt tcgttcattc 2132041 tggcttcgat tggtatgtcc tgtcttgtaa ttgttgtttc catcggcctg tttatttttt 2132101 tgcgtttcag cactttttga aaagctccga tcatatcata gaccgtgaca gagagctttt 2132161 gctcagactg ttttacttct tttgcatatt cactcaaatc actcggcggt ttcgtgaacg 2132221 atttttgtct ttcttcttcc cgttctttta aatccttcgc cgcatcttta tattttcggt 2132281 actcaatcag cttttcaatc agttcctccc gcggatcttc ttcttcaagt aattcatctt 2132341 caaaaagctc ctcctcttgc ttcgggagca gcattctgct tttaatgctg agcagcgtgg 2132401 cagccataac caaatactcg ctggcaatgt cgagctcaag cacgcgcatc gtatgtacat 2132461 ataataaata ttgttcagtg atcttcgcca caggtatatc atatatgtca atttcaagac 2132521 gattgattaa atgaagcagc aggtccaatg ggccctcaaa cgtatcaatt ttcacttgat 2132581 attcttccat catctcacca ttttcaagta tcactctcat tgccggaaaa actggctacc 2132641 ctatagtata agccaccaaa aagctctcgt ccaatactat ttcatatcct gttttgaagg 2132701 agtttgtaca gaatattcaa aacacaagag gtgtttgctc ggagcgcaga agcgggagaa 2132761 aaagcctttg cttctggttt tcctttctaa gaagcactag aggccgggcg ttcttttttc 2132821 cttttatccc ttctatggta cactaaaagc acattaaagg aggaagcacc ttgtatccga 2132881 aagcttatat agattatctc gttgagtttc atgcgacacg ggattatttt gaatgccatg 2132941 aaatattaga agaatattgg aaggaagatc cgccaaagaa acgaaaacgc tattgggtgg 2133001 gctttattca gcttgcagtg gctttatatc atcacagaag gcagaataca gccggggcaa 2133061 aaagactgat ggcgaacagc atccggattc ttcaagcaga acaccgggca gtcgaagact 2133121 tagggcttga tcatggccgt ttgctcgaac ttatgcaatc ggtttacgaa caaatcgaaa 2133181 ccgtctctgc ctataaaagc attatactgc caatcaaaga tgagaaactg gaggaagcat 2133241 gcaggatcga atgcaggaaa aaaaagtata catgggggca gcccagtgca ctcagcaaca 2133301 tatttcttat cgacaaacac cgtttgcggg atcggactga cgtcatccgt gaacgtgaaa 2133361 aagaaataga acgcagaaaa aaaagcagag actgatcaca gcctctgctt aattattgta 2133421 tgaaatgtct tgatcctgct gaccttgaca acgttcgaaa aagctctgcg ttaattcatt 2133481 tggaaccagt acttgcgttt tgaataaatg ctttaaagca tccatcatct gttttccgat 2133541 tccttgatgg cgatgagaag gattcacact gatatgccgg atctcaacct cagaatcctt 2133601 tttttcgact ccgattgctc cgacgatatc ctcgtcctct ttccaaagaa agagctggcg 2133661 gtctgtatcc gtttcgtagt ccttaattgt ctgctgaagc tgcttaaggt ctttttcatt 2133721 cggcataaac gaaagaagcc ccatcgcaat cttttcaaac gattttttat aacgaattaa 2133781 cataaaaacc cctctatatc caaaatgtcc agtctgctat taacggatac gaataggtga 2133841 tccgttttct cacattatat cattttcgcc atatttttaa actgttttca gcaaattatt 2133901 caaatgagcg gtttaaattt gccatttcaa tggcagaaac agcacaatct acacctttgt 2133961 tgcccgcttt tgtgccggca cgctcgatag cctgttcgat gttttcagtt gttacaattc 2134021 caaagatgac aggtacacca gtagtgtttg ctgcttgcgc gatgcctttt gcagcttcat 2134081 tgcagacata atcgtaatgt gtcgttgcgc ctctgatgac agtgcccaat gtgataatag 2134141 catcatattt ttttgtttcc gccatttttt tcgcagcaaa cggtatttca aatgcgcctg 2134201 gaacccaagc cacatcaatg tcatttgtgt ctacgccatg tctgagcagc gcatcttctg 2134261 ctccgctcag cagcttgctc gtaataaaat cattaaatct tcctactacg attccgattt 2134321 taagacctgt accaactaaa tttccttgta tgatattcat atgattccca tccttttttg 2134381 tgatatttgt gattagaaat gaagtaaatg acctagcttg ttcattttgg tttgcaaata 2134441 ttttttattg tgttctttcg cctccatttg aagcggcact ctttctgaaa tactgagtcc 2134501 gtagccttca aggcctgcga tttttcgcgg attattcgtc aaaagcttca tattccggac 2134561 accgaggtcg cgtaaaattt gtgctccgat gccatagttg cgaagatccg gcaagaatcc 2134621 aagcgcctca ttggcttcta cggtgtcata gccttgttcc tgaagcttat aagcttttaa 2134681 tttattgatt aaaccgatgc ctcgtccttc ttggcgcaag tacaggagca ctccacggcc 2134741 ttctgcggca atttggttca gcgcggcgtg cagctgcggt ccgcaatcac agcgatgaga 2134801 gccaaacacg tcacctgtga gacattctga atgcacccgg accaataccg gttcttctcc 2134861 gaacggcaca tctcccatca caaatgcgac atgctctttt ccatctacct catttgtgta 2134921 tccataaacc ttaaatgtcc caaaatcagt aggcagcgta atgtcaactt cacgctcgac 2134981 aagtgttgtc agattgtaac ggtattgaat caaatcctta atggtgatca tttttaattg 2135041 atgctttttc gcaatttcaa tgagctcagg cactctcgcc atcgttccgt cttcattcat 2135101 aatttcacaa atgacgccgg ctcctggaga tccgcaagct tcagcaagat caacagcagc 2135161 ttctgtatgg cccgctcttt tcaggacacc tccttttttc gcaatcagtg gaaaaatgtg 2135221 ccccggacgc tgaaaatcag atggcacgga tttgctgtcc agcaatgctt gaacggtaaa 2135281 agatctttct tgagcgctga tacctgtctt cgtttcacga tggtctatgc ttacggtaaa 2135341 tgcagtgtgg tgagagtctg tattatgctc aaccataggg tgaagatcaa gcctgtctgc 2135401 gatttcctca ctgagcggcg tgcagatcag tcctctccca tgtgtcgcca taaagttaat 2135461 gacttccggc gttgcatgct cggcaagagc cacaaagtct ccttcatttt ctctgtcttc 2135521 atcatctaca acgatgatga cttcgccttt ttttaaagcg tccagtgctt cttctatcgg 2135581 atgaaacatg caaatcttcc tctctaaaag ccgttttcgc ttaagaaggc ttttgtaatg 2135641 gtttgttggg tcttattttc attggcttta tgcaaaaatc gatacatata ttttccgatc 2135701 atatcgcatt cgatattcac tttagagccg atcgtttttt ctgaaaagat cgtttcgctg 2135761 atcgtatgcg gtattaagga gatcgtcact gtgtcttctg tcaggccgaa tatggttaag 2135821 ctcacgccat ccacagtaat tgatcccttt aaaaccaatg tttttgttaa tgacgggtcc 2135881 atttttaaat catagtaaac tgcgttgctt ttctcttcaa ttcgtgtgat ttccgcagtt 2135941 ccgtcgacat ggcctgagac gaaatggcct ccgaaacggc cgtttgccgc catcgctctt 2136001 tccagattta ctttgcttcc ttttgttaaa tcattcagtg acgtagcttt gactgtttca 2136061 ggcataacat ccactgtgaa ttgatttttt gtaaaatcag tgacagtcag acaaatgccg 2136121 ttcactgcaa tgctgtcgcc aagatgaaca tcctctaaaa tctttgagca tttaatagtt 2136181 aaggccattg catgccctgc ttttttcatg gattcgattg tgcctgtttc ttcgataatt 2136241 cctgtaaaca tggtcaccat cctattcctt tgtcggtttt gccgtcagtt tgatatcacg 2136301 gccgatttgg gttatatcag tgaattgtaa taaggggaca tctttcattg attgaaaacc 2136361 ttcaccggag attaagctgg gagcatgcgt tcctccgatt agtttagggg caaaatagaa 2136421 gatgatttct tgaaaacagc cttctttgac aaagcttccg tgaacagctg aaccgccttc 2136481 cacatacacc gacatgatgc cttcttccgc taggatcttc aaaacatcag gaatttgaat 2136541 gcgctcggtt tcaagtgtaa atatgttcac tccgaaagct gaaagccgtt ttttcttttc 2136601 ctcgtctgcg cgtgccgtcg taaaaatcca tgtcggcgct atttgatcgc aaatcacttt 2136661 agcgtcctca ggaatcgaga gtacggtatc aagtatgacc cgaaccggct gttttgttac 2136721 attcggcagt ctgcaggtta agctcggatt gtcggctttc actgtgccaa ctccgactaa 2136781 aatgctttgg tgtgttttcc tgtattgctg agcatcctgt cttgcagcct ctgacgtgat 2136841 ccatttgctg tcacccgtgc tggtagctat cttgccgtca aggctggcag ccgcttttag 2136901 cgtgacgtac ggaaggcctg tcctcataaa gtgcagaaat ttttcattca gcctctccgc 2136961 ctggtctgcc aggatgcctt cccttacctc aatgccagct tctttcatca tgctgatccc 2137021 tcttccagcc acaagcggat taggatctct catcgccacg aacactcttt tgataccaga 2137081 gttgataatc aattctgcac atggcggtgt ttttccgtaa tggctgcacg gttcgagtgt 2137141 aacgtaaatg tcggcaccct ctgcatgtgc tccagccata tggatggcat gaacttctgc 2137201 atgagcttca ccatatttta aatgggcgcc cattccgaca atttgtccgt cctttacgac 2137261 aacagcgccg acgagcggat tggattcggt ctgtccttcg ccctgcttcg caagatctaa 2137321 ggccagcttc atataatact cttccatttg tttccctccc ctcttttgtt atttaccgtc 2137381 aaaaaagccc cgaatttata aaaaattcgg ggctttaggt attttacgca ataggaaata 2137441 acactatgca tttttaaaca ttttgcatag cggctcatca tccttctccc atccagactt 2137501 tcactgtcgg cttcagctta aactgaatcc accgcgtgct tatgcacacg ggtcacgggc 2137561 tctaaagcaa atgtgcttta ctaccgccgg tcgggatttc caccctgccc cgaaggatac 2137621 aatctttatt catttgtcct tattggttat tatagcgatc ctttttaaag tacgcaatga 2137681 aataaactta caatttgaga aaaacaaaac atcacccttc gatccgaaag gtgatgtttt 2137741 ttaatcattc acttttgcaa ccttgattaa tccgtcgatc cgctttgatt tgctgaagta 2137801 agccttaatc ttgtcacctt cttttatatc agataaatcc tgatttaatt tttttccgtt 2137861 gaagatgatt ttcgttccgt tttctgctac tccatgatac tctgagccgt caattttcgt 2137921 cactttatat tcctggatgg tgtattcctc ttcttccgag gacaaggttt gtccaattgc 2137981 tgtcggaaca tccttcagct caatatcatt tatgtacata taaccgcctg caagtaaaag 2138041 caaaagcact aacagaatgg taatcttggt ttttattctt cccatttcta aacctccagc 2138101 caatatgaat ctattcattc atatgagtta ttcctttttt tcatgaataa aaaaccgtaa 2138161 attctcgtaa attattaata taacgatgca taacgggaat atgtttcaca tttctgcaaa 2138221 aatttctttt ctatagatat acgaatttat gttctgtttt taggggatga ccgtaaaaaa 2138281 gatataaaaa aagcagcccc aatgggaagc tgcttgatcc taatttgttt tgcgcatttc 2138341 gttaaacggg tagaaaacaa actttgacgt acccgcaatt tgttttttcg tgaagaggcc 2138401 aaggccgtta cggctgtcca tggaattgcg acgattgtca cccatcacaa aatacttgtt 2138461 atcaggcact ttaaccgggc cgaaatcatc ggtcaaatgg tcaaaaccgt cctgtttcgc 2138521 tctcttttta ttagccgcca aataaggttc gtccaccttt ttcccgttga tatagagctg 2138581 gtcatttttc atctcaaccg tatcgccggg aaggccgata atacgtttga catagtgaac 2138641 atcatctccg tttaacacga cgatgtctcc tctatcaaac tcgccgatgt atttgactgt 2138701 catattaaca aaaacccttt cacggttgtg aagtgtagga tacatagagt caccatcaac 2138761 gacatacggc gcaaaaataa agttgcggat gagcaaagca agaacgacag caatcacaat 2138821 tgcttttgcc cattctaata ttgacttttt cttcgaaaca ttttctgatt tcaactgatt 2138881 tcctccaata aacaacggtc ttcaatttat gttatcacga atcgaaaaaa aatcccatta 2138941 ggaccattga agtgatttta caaactgtta atcttcatct tctacccaca tcatgcctat 2139001 tttttcttgt cgatcataac taggcctgaa aatattgaaa gaaatgaatc gcataattca 2139061 gaagcgatgg actcagaaga aagagagttc tcatatgcaa aatctttaga tcgtatataa 2139121 agcatgaggt tacgggcagt ttgttcattt actgcattcc attgatctcc cagtccatga 2139181 tacccatggc acttgacaaa acaattaacg tcatgaaggt tactggaatg tttgcggcaa 2139241 cctatttcac aggtgataac cgcaccccgt tttttgcttt cataatatgt ttaaaatcat 2139301 tcaagctcga aaacatggat cagcctccaa aaaataaatc caatatattc ccggcagttg 2139361 aagactcttt attataaaac tctgaatatc cgcagttctt acagtaaacc actagaaatc 2139421 ggttatgctg cacgtcaaac agctttgata atcccgtgcc ggttgtagct atttcttttt 2139481 gtccggcttc agtactaccg cattttatac agcctttgtt gttcatatcg cgatctcctt 2139541 ttcattacat cacgtttgtt tgatttattt tactacaaaa tatcaatccc aatgacccgt 2139601 actactttaa agtttactta attttgatta catactaatt gggttcgttt ctcagcttgg 2139661 taaatcttct ggagaaacgg aaaagctcca tgaccaaaac attcaaactc agccaaacac 2139721 cgccgaaggc gtaacccgca gcaacatcac tcggatactg ctcataaagt acacacggct 2139781 cagcccgatg aggaataaaa cgataataaa caaaaaaatg caacagtttg cagacgcgtc 2139841 ttgtgagaat gacgaacaaa aagataagca caaaaaccaa aaatgacaaa tgccgttaaa 2139901 gtctgttcgc tcgggaatgg atataataca tgactttcca aaggagcgtg aacaggatga 2139961 agggaatgaa agagccgtct gattccctct tcataaagct ccccaccaat gactaggaaa 2140021 aataagaaag agagttcgat tttccgatct tgccctctga ataccgtcca aaaaaaagtt 2140081 agaacaataa cggctaacag aacacctctc gacgcaaaag ctttctgaat tgcagctggg 2140141 cccagtctat acccgatcca atacgacatg ctcactccca cagctcccca atccggccgc 2140201 taacatgctt agcacccagt ttaacttttc ttgaaacacg agaacaccgg caaactctcc 2140261 cggtccaagt aaagctagaa gctctaacat caagacaata aacaagacgg catatccgta 2140321 ctgttcgagc aaccccgtca aaacttgcat gtgattctcc ttaaactttt ttgttctttt 2140381 atcattccca atccactttt tgtataatca gcacaatttt atcttcagtc gtccaacaac 2140441 attgtctatg gcgggatctt ctctcataca ttcttttttg acataggagg agcaatagca 2140501 tgaaatggga ggaaacaaaa gatacgcagg gagtttgcca aaattttggg cagttcgttc 2140561 tgccaccgag tcaggtgttt gtttgcccac ctcatccctt gtcaattccc catttttccc 2140621 gtttgaggtt cgaaatggta aagtatttca cttagtttct tacatgaaga ggtaaattct 2140681 ttgctcaccg aactaggata gcggcgtatg gcgatttcta cattgcataa ccactggtta 2140741 tttagtgagc cgtgagcaat gtatatgcac tttgagtcag cacaggatga tcctattaca 2140801 ttcgccagaa aagcagctgc cgcattcaga gtagttaaaa gaatagacag atatctgggc 2140861 ttccggaagc tttaaaggag gctctttttt cgagcatttt tataaatcaa taaaaacagg 2140921 catctcctaa atatttttgc cgataagttt acgctaatca actctagcac taatacatat 2140981 aaaaaataga atgatatgaa aggagacttg atagtatgat tgattatcct attaatataa 2141041 acaacgtttc cgggaacagt gtaattaacg taggcggcgc ttttatgatc aggcctttaa 2141101 ctttgtccaa atctgtgttt ggctccggag gtttaaacac aggaattgtc tttgaaaata 2141161 actttgtaag caaagctaaa atgattaatc atcaatttac tgatcaaaac gtcaccaaaa 2141221 ctttttaatg tattcaatac acgggggtca ctaactaaac acctggtttt gccaaccgcc 2141281 atcagcattc ggcggttttt tattgaacat ttttggccaa taaaaaaagc ttcctctcta 2141341 agaggaagcc ttttgcctgc cgattagcct tctacacgaa cttctttcat gacatcgcca 2141401 ttagacatgt ttttcgcgaa ttctaatccg cttgttactt taccaaatac agtgtgaaca 2141461 ccgttcaaat gaggctgtgg ctcatgaacg atgaaaaatt ggctgccgcc agtgtctttt 2141521 ccggcatgtg ccatagaaag tgcgcccgcc tcatgtgtat gcgggttgcc ttctgtttca 2141581 catttgattg tgtatcccgg accgcctgta ccagttccgt gcgggcatcc gccttggctg 2141641 acgaagccag ggatcactcg gtggaatgta agcccgtcat aaaagccttc gttcgcaagc 2141701 ttttcaaagt ttgcaacagt tccaggtgca gcttcaggat aaagttcaaa ttcaattttg 2141761 ttcccgtctt ctaataaaaa gtaacctgtt ttcaattgta tgcctacttt ctttatttta 2141821 attttcaaag gagattatgt ataggttata gcctgtctct ccttgtcgcg gctattatac 2141881 cacacctttc gggggaaaac gaatctcccg agctttacta aaaaataaaa atgaaacctg 2141941 aatctcttta tctccgtcta acctaacgga actgtatttt tcatgattca ggtcctcaca 2142001 aagcagcact atccagctgc ttgtgaaatt gaaggaggtc aaactgcttt gaagaaaatt 2142061 tggattggaa tgctggcagc ggccgttttg ctgctgatgg ttccgaaggt cagtctcgcg 2142121 gatgccgcag ttggagatgt cattgtaaca ctgggtgctg atttgtcaga atctgacaaa 2142181 caaaaagtgc ttgatgaaat gaatgtccct gataatgcca caacggtaac cgtgaccaat 2142241 aaggaagaac atgaatattt aggaaaatat atatcgaacg cgcaaatcgg atcgagagcg 2142301 atttcttcat cgtcaatcac cattgccaaa aaaggctccg gattgaatgt tgagacccat 2142361 aatatcagcg gcatcacaga tgaaatgtac ctgaatgcac tgatgacagc cggtgttaaa 2142421 gatgcgaagg tgtatgttac agcaccgttt gaagtatccg ggactgccgc tttaactgga 2142481 ttgattaagg cgtatgaagt ttcttctgac gaagcgatct cggaggatgt taagcaggtc 2142541 gccaaccaag agcttgtcac gacatcagag cttggagaca aaatcggtaa cgaaaatgcg 2142601 gcagccctga ttgcaaaaat caaagaagag tttgctaaaa acggggtgcc tgataataaa 2142661 gctgacatcg aaaaacaagt ggatgacgca gcttctgatt taaacgtcac acttacagac 2142721 agccaaaaga atcagcttgt ctccctattc aataagatga aaaacgctga cattgactgg 2142781 ggacaggtca gtgaccagct agataaagcg aaagataaga ttacgaaatt catagaatca 2142841 gatgaaggca aaaacttcat ccagaaagtc attgatttct tcgtatctat ctggaatgcg 2142901 attgtatcta tattcaaata agaaaagcgc cgaaaaatcg gcgctttctt ttattgcttt 2142961 acacccgttt taaatggcag atcaagtttt acaatatctt cgtatgtttc tcgcttcacg 2143021 actaaatgag cctcaccgtt ttcgacaaat acaacggcgg gtctcggaat acggttataa 2143081 ttgttggcca tgctgtatcc ataagcgcct gtacaaaaaa cggcaagaag atcgccttct 2143141 tttacttccg gcaggtcaat atcccaaatc agcatatctc cgctttcaca gcactttccg 2143201 gcaattgata ccgttttgtc atgcgcttct ccgatcctgt tggctgccgc agcttcatat 2143261 ttagcttggt aaagcgcagg acgaatattg tcgttcatgc ctccgtctac agccacatat 2143321 tggcggacac ccggcacttc tttttgagag ccaaccgtat aaagagttgt gcctgcgtct 2143381 cccacgagag aacggcccgg ttcgatccaa atttccggaa tgtcaaaacc gtaacgggaa 2143441 gcattttctt tcacagcttc gataattttt tcaacgtatt cagtggcatg aagcggttca 2143501 tcatcttccg tataacgaat gccgaaacct cctccaagat tcagcacctt ggatacaaat 2143561 gaatatgaat ctctccattc gtctagtttt ttgaagattt tttccgctgc taacacaaaa 2143621 ccggccgtat caaagatttg cgagccgata tggcaatgga cacccagcag ctgaatgtgt 2143681 tccgattgta atacttgttc aatggcccgt tcagtttgtc cgttatgaag atcgaaacca 2143741 aactttgaat cttcctggcc cgttgtaatg tagtcatgcg tatgcgcttc tactccgggc 2143801 gtgatccgaa gaagaacatc gatggagtga cccgtttctt tacataggtc ttcaagaagc 2143861 gcgatttcat agaaattatc caccacaatg cagccgatgc ggtgctcaag cgccatccgc 2143921 agttcttccc tgctcttatt gtttccatga aagtggatgc gttctgccgg aaagcctgct 2143981 gcaacagccg tatatagctc tcctccggat acgacatcta aagaaagtcc ctcttcctca 2144041 gcgagctgaa tcattgcgac tgatgagaat gctttgctcg catatgccac ctgtgctttc 2144101 agccctgcag aaataaacgc ctgcttaaag cttttagcac gctcacgtat taaagccaca 2144161 tcatatacgt aaagaggtgt accatatttc tccgctaaat agagagcatc cacacctccg 2144221 atttctaaat gaccatgttg attttgtctg cttgtgccgt gtaagaacaa tgtcattccc 2144281 tctttctccg cttatggatg aaaggacagt tttatggact gtcccttcat aattaagaca 2144341 tacattatca tactcttcag tcagtttcaa tgcgattatg aattggtagg ctgccttaag 2144401 cgatttttgg ggtgaacgat gctgggtctt acttttgcgc caggtttcgc tgtgcggaca 2144461 agaacctgcc acagcgcctt tccgttaaag ggaatcagcg gccataagta cggtgtctga 2144521 agggatttga tgcttgccat ggcaataatt agcactgtaa atccgatgac gagccctttt 2144581 atatgaaata aagcaacgag tatcatgagg acaagacggc tcattttgtt tgccaagctt 2144641 aattcataac taggcgtcgt aaaggttcca atcgccgcaa gtgagacgta cagaatcacc 2144701 tcaggagaaa aaaggccgac ctcaatcgca atctgcccga tcagaacagc ggcaattaaa 2144761 cccattgctg tcgataaagc cgtcggtgtg tgaatggcag ccattctgag aaactcgatt 2144821 cctaagtcag ctaaaaatat ctgcaggatg atcgggatat gcgtatcttt atttaaaccg 2144881 ataaatttca tgttgtccgg gagcagatca ggctgaagca caaagagaaa ccagatcgga 2144941 agaaataaag tagaagcaag aataccgaaa aatcttaccc atcttaaaaa ggtcccgact 2145001 gaaggcgcct gcctatattc ttcagcatgc tgcacatggt gaaataaagt cgtcggggta 2145061 atgatcacac tcggcgatgt gtccactata atgataacat ggccttctag aacatgattt 2145121 gcggccacat ccggtctttc tgtatagcgc acgagcggaa aaggattata gctttgatta 2145181 acaatgaatt cctcgacagt tttgtctgcc attgttaatc catcgacatc aatggatgca 2145241 atttcttttt ctacgatctc aaccagatcc ggatcagcta tatcttctat ataacaaatg 2145301 cttaaatccg tctttgaccg ctcaccaact ttagtcatct tgactcgaag gcgttcgtct 2145361 ctgatccgcc ttctgagaag ggccgtattg acgacgatat tttcaacaaa tccgtctctg 2145421 gctcccctga ccaccttttc cgtatcaggt tcttccgggt ttctgcccgg atagcttctg 2145481 acatcaatta taaatgcgaa gcctgcacct tcaacaatga cagcgacgag cccggacagc 2145541 acttggtcgg tggtttcatc caaggttttt actttttcga cctgggcgtt aagcagcctg 2145601 ttttcgacga tgtcgaccag ctcatcaggg tcttctttcc gattgttaat ggcaacaagc 2145661 tctctcatta aatgaataat ataggctgta tcgcataatc catttagata gtaaagctgg 2145721 atctctttat ctaaaatcgt gagcttgcga acacctacat catagctcgt ccccatccca 2145781 acacggtttt tgaaatactc ttcattttta gctggattcc gataaacccg aattttctct 2145841 tccttgtggt ccggcatgat acccgctcct ttctaaaata aactcgaccg ctttcatggt 2145901 gattggcgac ccttttgaga tatcgtcttt tctgcccatt ttgccgatat ccccgatacc 2145961 gacaataagc gggagatcaa gtttatcaag gcaatagact gtatctccac tcattctgtg 2146021 gtcatcaaat tccctttccc cgactttatc gacgccgtat tcagttattt ctccattgcg 2146081 gtcaatgctt acatcgaccc tggtccattc agcctgatgt gtttttgacg cgaccgcaat 2146141 cacaccgagc acttcaatag acggatgggt tgcgacatag gttagagcgg cttctcccgg 2146201 gccctctcct tgaaggccgg agtcgtcaaa catgacaaat acaggatcat acggtgctga 2146261 ggcgatcagc ttgacaagct cggcgccgct gcgggtggaa ggattccctt ttgattgtga 2146321 aatacatcgg cctcccactt tgcttgcggc gtattcaatt gttttagcgg cataaacatc 2146381 cccgtctgtt accagtatga ccttgcgttt tgtcgtcatg tcggcattat cctttcggtt 2146441 tgaaaataac agctacgata aaggcgaaaa gaatagcggc tgagataccg gccgaggtca 2146501 gctcaaaaat ccccatgccg attccgataa atccgtgtat atgcgcctga tgcatggcgc 2146561 cgtgcagaag actgtgaccg aagctgacga tcggaacggt ggcgcctcct ccggcaaatt 2146621 caataaattt atcgtaaatg ccgaaaccat ctaatattgc accgattaca acaaatgatg 2146681 tcatgacatg agctggcgtc aatttaaaaa tatccaagag cagctggccg acgatacaga 2146741 tggccccgcc gcagacaaaa gccaaaaggt agtccatatt aagatgcacc tcctgcacgc 2146801 tcaaatacaa ccccgtgggc gatagtcggg atggtttctt tttgctggat catcgtcggg 2146861 cttaatagcg ccccggtcgc cacgacaaat acacggttta gttttccttc tctcagctgc 2146921 ttaaaaatat gagagtaggt gacaaccgct gaacaagcac agccgctccc cccggcaaag 2146981 acctgctgat ccggagtgta aatcagaagc ccgcaatcat catgctttgt gccgactgga 2147041 tatccatctt cttttaaaat gtcttttacg attggagaac cgacgcctga caggtcacct 2147101 gtcaggatta gatcatagtc atccgctgtc cggttgagat ctttaaagtg ctgcttaatc 2147161 gtatcagctg cagccggagc catagccgat cccatatcaa aaggatctgt aattcctaaa 2147221 tcagaaacct tcccgacagt cgcacttgtg atttggatat cacccggtgt ctgactgatg 2147281 acaactgcac cgcttccggt tacagtggag gtagcagtgt ccggtttttg gcctccgtat 2147341 tctgtcggat agcgaaactg tctttccgca gttgcattgt gactgctggt ggcagcgagt 2147401 gcccttttgg caaaccctcc atcaactaag gctgatgcga cagccactgt ttccattgat 2147461 gttgaacagg cgccaaacat acaaagaaat gggattttca agtgtcttgc cacatagtta 2147521 gccgtcacgt tttggttcag caagtcgcct gccagcaata ggtcaatatc atcttttgtc 2147581 agattgtttt tttgaagtgc aacattaaca gcgtcttcca tcagctgccg ttccgccatt 2147641 tcccagcttt tttgattaca atgcatttcg tcataggttt tatcaaataa agagccaagc 2147701 ggtccgtctt tttcctttgg tcctgctgcc gttcccgctg agttgacaaa tatgggatgt 2147761 tcaaataccc aggtttgctt tcctgttaat ttcattttct tctcctccta tgacatcagt 2147821 ttctcaaaag caaaccgaat cattccaacg atgtatgcag ctacaactcc gaaaacaata 2147881 acatttcctg ccagtttaaa catatttgtc gctactccaa gcactaatcc ttcgctttta 2147941 tattcaagag ccgcacttgc catactgttg gcaaaacccg tgacaggtac ggctgaacct 2148001 gcgcctgcga attgtccgat tctgtcatag attccaaacc ctgtaagcag ggcagaaatt 2148061 aatatcagcg ttgcagctgt tggattcccc gcagtttttt cattgaaatc aaaaaaatgg 2148121 atataaaaat tttgcagacc ttgcccgatt gcacaaatca gtccgcccac taaaaaggct 2148181 tttacacagt tccagacgta aggcggctta ggctgatatg ttttcacttt tgatttgtaa 2148241 ttttctttta tgtttgtcat cttgaaacct ccttatgaat ggtcaataaa gtacagccag 2148301 tgaaataaag atcccgcgat tttcccaatc acgatggcca ttaacagaat aatgatttta 2148361 cttctgagcc cgattcgttt cgccaaaatc ggcaggacat ttaaaacctc tgtaagagca 2148421 gccgctagca tcccgacgaa caaacctgcc agaagcccga ccggcacagc tatccatttt 2148481 gttagataaa gatgattcat atgaagcgtc tcccatcccc cgcaaaccgc gccaagaata 2148541 acagccgctt cataagcctg aacaaatctc attgttttgg tgagctgcat cagccgcgga 2148601 atgattccca ttacggttaa aaaagcaacg aaacccgccc ccaccgttat gcctccgccg 2148661 agcccgacaa aaatgatgaa caatacacta acgatcatgc agatccttta tggtttcttg 2148721 attctcatgc atggccacat attgatcgag atcaagctga tagttaaaca tctcaacctc 2148781 cagcgggctg ggctcttcat ttaggcgctt tttaaatatg tggttaaaaa acacgatcat 2148841 ccccagtccc aaaccgatgc tgtatgggat ttgaagcaaa tatggatagt cattcctctc 2148901 tccggttatg atttcatata gtgcgatatg aacatctctc atgcttacat cctcatgaaa 2148961 gttcatgatg gcaagacacg atccaataaa cagaagcagc cagacaccga taaatagaac 2149021 cgttgataaa tttcgctttc gatactgaat ttcaacaatg gtttctgctc cgcctacggt 2149081 ttgaacatca attgtcgggt cttgtaaatg aatggctctg aggacttgta tgatatccag 2149141 aattacgata tttttatctt tttcgctcac ctgataaagc ggcatagccg aaagtttctt 2149201 tttcagctga agctgccctt ctatttgcgc ggcatctcca acggtaataa tatcccctgg 2149261 atgtgccagc actcggtggc gaagccggat aaatattcgt cgttccatca ttgatcacca 2149321 tctttcggtg gttatatatg tagtatgtgg ttcgattttg ttctcattca tccgctcgaa 2149381 aagaccataa attaccacgc ttttgcacaa aaaagctagc ctgcactgca gactagccat 2149441 ccgtatgatc catttgaacc ttgatctgtt ttaatatttt cttttcaagc ctggaaacct 2149501 gcacctgaga gatcccgagc cgctcagcca cctcggactg tgtctggtct ttataatatc 2149561 tgagatagac gattagtttt tccctttcct ccaaatcgct gatcgcttct ttcagcgcaa 2149621 ttttgtcaaa ccatttttct tctgagttgt cagcgatttg atcaagcagg gtaatcggat 2149681 ctccgtcatt ttcataaacg gtttcgtgaa tcgaagatgg agcccttacc gcctcttggg 2149741 ccagtacaac atcctcagct tcaatctcca aatggtcagc gatctcctgc accgtcggca 2149801 ctctgcccag tgttttcgaa agctcatcct tcgcgcgccg gattttgttt ccaagctctt 2149861 ttaatgaccg tgataccttt acggttccgt catcacggat aaatcgttgg atttctccga 2149921 taatcatcgg cactgcatac gttgaaaaac gcacatcata ggttaaatca aatttgtcaa 2149981 cagattttaa cagcccgatg cagccgatct ggaagagatc gtcaggctca tatcctctgt 2150041 ttaaaaaccg ctgtacgaca gaccaaacaa gacgcatgtt tttttctatg aggaggtctc 2150101 ttgcctgctg gtcgccattt tggctttgtt tgattaattc ctttacttca tgatccttca 2150161 gctgagcgtt tttgccgttt ttcttaacct ccacatccat aacaaatctc cttaattaca 2150221 aagcgctttg ctttttgata agtgctttgt taagcgaatc gttgttccca tttcaggcga 2150281 tgaatcgata ctgacatcat ccatgaaatt ttccataatg gtaaagccca ttccagagcg 2150341 ctcaagctca ggcttagtcg taaatagagg ctgacgggct tcttcaagat ctgtaatgcc 2150401 taagccttca tcacgaatag tcatatatac gacatgatct tccagcgtca ctgaaatgta 2150461 aactttccct tcacagttct cttcatatcc atggataatc gcattcgtga cagcctctga 2150521 cacgactgtt ttgatttcag tcagttcatc cattgtcggg tccagctgag ctataaatga 2150581 agcaactgtc acacgggcga acgattcatt ctgactgagg gcagaaaact caaggtgcat 2150641 ttcatttttc atgatgccac ccccagtgtc aggagtgcct gctgttcaga ttgttcaaat 2150701 cggataattt taaacagacc cgacatatca aacaatcgct tcaccgcagg agagatagcg 2150761 caaacaacca tttctccgcc aatttgctta atttgcttgt atcttcctaa aataacgcca 2150821 agccccgagc tgtccataaa ggaaaggtcc tccaagttca gcacgatatg gcgaatatca 2150881 tccttctcca atgattgagt cactttttgc ttcagggttt cagccgtatg gtgatcgagt 2150941 tcgcctgtta atcgaataca aagcacagat tctttgacat tcatgtcaat tccaaggctc 2151001 atgctcattc ctccttgata tgatcggata atgagtgttt cgatttcgac ggaatgaatt 2151061 ccttcaccgt gacaaaacta gtggtcattc ggcataatta cttaaatttt gtccagtctc 2151121 ccatcgtccg ctttaagaat gtgataaacc cggctttctt catatcttct tttgcagcaa 2151181 caggactttc agcgagtact tctccatcct ttttcagaac aagagtgcca agctcttggc 2151241 ctttttgaat cggagcacta atattgtcct tcatcttgat ttcttttttc acatcgttca 2151301 tatcctcgcc ttttttcgtc aatattgaaa tcggctcaga tgtagtgagt tcgataaatt 2151361 tttgtttccc ttttttgacc tttacttttg ctactgtttg atttcgttta tataaaggat 2151421 gcgtttcata ttggctaaag gcgaagtcaa gcatttttgt cacttgcgcg tttctttctt 2151481 taggcgtgct cgctccgaat acaaccgcta tggcccgcat gtttcctttt ttagccgaag 2151541 cagtcagaca atatttcgct tcgcctgtat agcctgtttt tacgccgtct acaccaggat 2151601 aaaatttgat aaggcgattt gtatttacaa gccaaaactt tttatctgta ttttcacgca 2151661 gataatcttc atacgtgccg gtaaacttcg taattgattc gtatttcaat aattccttag 2151721 ccatgattgc catgtcataa gcagagctgt agtgtccttc ctcggtcagt cctgttgggt 2151781 ttttaaagga tgtatttttc aatcccagct cttttgcttt tttattcatt ttcttcacaa 2151841 attcttcttc agagccggaa ataaattcag ccatggcgac ggaagcgtca tttcccgaag 2151901 cgattgcgat gcctttcagc atttctttga cagtcatttc ttcgccgggc tcaaggaata 2151961 tctgtgagcc gcccattgac gccgcatgct cgcttgtacg gaccttatca ctcattttga 2152021 ttttgccttt atctaaagct tccataatca aaagcatcgt cataattttc gtcatgcttg 2152081 caggcgccag tctctcattg ctgttcttgt tgtaaagcac ttttcccgtg tcacgttcta 2152141 tcagcaccgc agacttcgct tcatgagcaa gctccgatgt acgttttccg tcttgttttg 2152201 caaatgcaga cggtgcaaat gtaagcagca ttataccaat caacaaagtg gataaaagac 2152261 gtttcatctc aaaagccctc catttcataa tcctttttat tttttccaag cgtgatggtt 2152321 ttatacgcca ctgatggaaa atgtttcgaa ttttgggcat aaaaaaagac agctgtgtga 2152381 tatcagacac agctgtcttt tggtcctgca ttgattcata tttattcgta ctgagcgacg 2152441 atcgctttaa caagctttaa gaatccagct tttacttttt cggtcacttc cataacttca 2152501 tcgtgactta aaggctgatc cagaattccg gctgccgcgt tagagatgca ggaaatgcca 2152561 agaacccgca ttcccgcatg attcgctaca atgacttccg gaacagtaga catgccgact 2152621 gcatcagagc ccatcgttct taagaaacgg acttctgccg gtgtttcgta agaaggtcct 2152681 gtcacagcag tgtacacgcc tttttgaatt gggatattaa ggtctttcgc aatcttttca 2152741 gccaggctgg acagatcttt gtcataggct gaagacatat ctggaaatct ggcgccgaaa 2152801 tctgcttcgt ttggcccgat taacgggttt gttcccataa agttgatatg atcggtaata 2152861 atcattaaat ctcccgcacg gaattcagtg ttgacaccgc ctgcggcatt tgtcacgatc 2152921 aacgcttcca caccgagcgc tttcatcacg cgtacaggga atgtgacttt ctccattgag 2152981 tagccttcat aaaaatgaaa gcggccctgc attgcaatga cggaaactcc ttcaagagtg 2153041 ccaagcacaa gctgtccggc atgcccttca acagtagata ccgggaattc aggtatatct 2153101 tcatatttca gcttgaccgg attttcgatt tcgtccgcca aaatgccaag acctgagcct 2153161 aaaataaggc cgatctttgg agattccggc aggttttgtt taataaaagc ggctgcgcgt 2153221 tcaattctgt ccttcaagaa acagtccccc tattgtaata aagataaaaa gcttttcccg 2153281 tatttcggtt tatttgtttg gaaattatca gcgatcgttg cgccaatatc ggcaaatgta 2153341 tctgcaagcg gcagcatttg cgctttctta tgttttttgc tgtaagcgag aatcggcaca 2153401 tactcgcgtg tatggtcagt cccatgatga atcggatcat tgccgtggtc ggctgtaata 2153461 attaacagat cgtcttctct cattttttca aacacttccg gaagccgcgc atcaaattct 2153521 tcaagcgcgc gtccgtagcc ttcagggtca cggcggtgtc cgaataacgc gtcaaaatca 2153581 acaaggttcg caaagctcag acccgtaaaa tcttctccca gcgtatcgat caccttgtcc 2153641 attccgtcca tattagaaac cgttctgcgt gaagaagtaa tgccttctcc gtcgtaaata 2153701 tcagagattt taccgattga aatcacatct aagccgcagt ctttcaattc attcatgaca 2153761 gtgcggtcaa acggcttcag cgcataatca tggcggtttg gcgtccgttt gaattgaccc 2153821 ggctctccga cgaacggccg tgcaataatg cggccaacca tatatttcgg atcaagcgtc 2153881 agctctctcg ccgtttcgca aatgcgatac agctcctcaa gcggcacaac ctcttcgtga 2153941 gcggcaattt gcagaacaga gtcagcagac gtgtaaacaa ttaaagcccc tgtctccatg 2154001 tgctcctggc caagctcatc caaaatcgct gtgccggaag ccggcttgtt tccaataatt 2154061 ttgcggccag atctcttttc cagctcttga agcaattcat caggaaagcc ttccgggaac 2154121 actttaaacg gtttatcaat gtataaaccc ataatctccc aatggccggt catcgtatct 2154181 ttgccgtttg acgcttcttg catttttcca taataggcaa gcggatgttc tgttttttct 2154241 acacctttga tatcttcgat aagaccaagg ccgagctttg ccatattcgg catatgtaat 2154301 ccgttcatat gctcggcaat atgaccgagc gtatgagcgc cttcgtcatt aaagtcagcg 2154361 gcatccggcg cttcgccgat tccgactgag tccatcacaa ttaaaaacac acgattatat 2154421 ttgtatgcag gcatcttgaa agcctccttt ttttctatac gtctattgta tcgctaagag 2154481 gtctgacaac tcaagtataa accgttttca ttcccgttga caatgtattt ggaaataatg 2154541 agaaacttca atattttctg tcgctctaaa caaaaaagcc gcagccacct gcggctatgc 2154601 tcgcggatga aactgcttgt acacatcctt cagccttgtt ttcgtcacat gcgtataaat 2154661 ttgcgtcgtg gatatatccg catgaccgag catttcctgc accgctctta aatctgcccc 2154721 gttctcaagc agatgcgtcg caaaggaatg cctgagtgta tgcggagtca gctctttctt 2154781 aatgccggct tccaatgcga tttttttcag gttcttccaa aatccctggc ggctgatctg 2154841 tttgccgtga tgatttaaaa agagggcgtc agatacatta ttttttaaca gttttcccct 2154901 ggcttttgtc atatattcct caatggcgga agcagcggct tcaccgattg gcacaatccg 2154961 ttcttttctt cctttgccga agcatcggat aaaccccata gataaatgaa catcagccgt 2155021 tttcaattca atcatttcac tgactcgtat gcctgtcgca taaagcagct ccagcattgc 2155081 tttatcccga tatccgaaag ggctcgtcag cttaggcgtg tccaataacc gctcgacttc 2155141 attgagcgcg agcaccttcg gaagcgcccg ttccgtcttt tgtgtttcga tatgaacgga 2155201 agggtcctta tccgttactt tttccctgag cagaaattga tgaaaagagc gaatggatgc 2155261 caaatgccgc gccgatgtct tgccggattt ccccgagtcc ttcaaatgct ttaagtattg 2155321 gataatatgt atgcgggtaa cgtgattcca atctgtaaca tgaagggttt ctgttaagta 2155381 gagagaatag cttttcaagt cacgttcata ggatacgatc gtattttgag agagccctct 2155441 ctctaccata acgtagtgga tgaaatcctt tatttgatct ttcactcttg atctactccc 2155501 cgttttggta aaaaaagatc aaccggtcga accatccgcc tttttcatcc tgatccattt 2155561 caacaacttt tacagcggag ccttccggtt tatcataccg atgatagttt tcatactctt 2155621 gattcaccca tatcatagca taatagaaca aagcggtaaa accggtaaac aggatgaaaa 2155681 ctttcaatgc atcgacagct gttttcagga atcttcccat gtcctaatcg atcctttccc 2155741 tatggttcca gttatataaa ccatatgcca aatcagaaag gttttataca tagaaacagc 2155801 aaaaaaccct ttccccatga gaaaaggttc gcgctcggca ccgtctattc agtttctttt 2155861 ccgttacagc ggtggcaaat gccgtgaaac gtcaatctat gatctttaat cttaaatttc 2155921 caatcacgtt caatgatttc ttccacgtct tcaagcaaat cttcttcaat ttcatcaacg 2155981 gctccgcact ccatgcacac caagtggtga tgaaagtgag ctgcgccctc tttccgaagg 2156041 tcgtaacggg acacaccgtc tccaaagtta attttatcta cgacttttaa ttcagttaat 2156101 aattcaagcg tacggtatac tgtagcgaga ccgatctcag gagatttctc ttttacgagg 2156161 aggtatacat cttctgcgct taaatggtct tcttcgtttt caagcagcac tcttactgtc 2156221 gcttcacgct gtggcgtaag tttatagctg gatgagtgca gttgtttctt aatacgatca 2156281 atacggtttt ccatgtcttt ccctcctacg ccgcattcca tgactcatta taacaaaata 2156341 cgcgcagagt tccaactata attattataa actgataaat aaaatggttt tcttttaata 2156401 atgattttaa aaaagtctag atgtaagctt ttccattaaa acaggagata agtatgcttc 2156461 aaagagagat gaaatcagcg ctaaaaacag aatgaccagc agcacaaagg cataccgccc 2156521 gaaccattga atcggcgcgt catgcaggct tcgtttcacg aacagctgtc tgattaactt 2156581 taaagaaaac gcaattgcac atgtgcccat aatgagataa gccggaatca gcagcacatt 2156641 ttgcggcaaa acggagacaa atgataggaa aaacccgctt actcccatct gattgactag 2156701 gaacccgaca gtaaagccga cgacgatccc tttcagaaag atcataatga aaataatcgg 2156761 catcccaatg acggaaattc ccagtatcca catcaggcct aaatactttg cattatgaaa 2156821 gatactttgc ccaaacatat cagctgaact tgcctgtttt ccatccgaaa gctgtccaaa 2156881 aaattgactt aagtagtagt ataaatcttc tttctggctg atggtcatac tgttgacaat 2156941 aatcgcgcca aagatgacac ccatgaaaaa cagcactgac acaaatatat aaagagagag 2157001 atgatctttg acatgcctga gaaacatgtc cttataagag atttttcgca taccgtttcc 2157061 tcccgcccgc tctagtgatt tgatttaata gattgtatga aagaaacaga aaaacatgcc 2157121 ctttttcaaa aagaaacaat agagatgaat gctaggcggc tttttggggc acaaaaaaat 2157181 ccttatcatc aactgctgta tgatcataag gattcttatg cttccgttta ttcaaaatct 2157241 cttttttgct ttttgtcatt cttccatgtg tgctgaaaga tggtgtgctg cctcttgata 2157301 ataagacgtc acgtccgccg tttctcaatc gatgcccccg cttctttttc gcttggcttt 2157361 ttgccatgtg atcactccct tttttatttt catagtaatg ataacaaaat tgaacaatga 2157421 taagaaaaaa acagcacctg ctacgacagg tgctgtttag ctacatttat ttcactgctg 2157481 taagagctgc atgctcgaca gctgctgcta ccgcatgatg gacttttgaa tcaagcggct 2157541 gagggacaac atcaccttgt ttagtgcaag ctgcgatggc ctctgctgct gcgacaagca 2157601 tatcatgatt aatctccgtg ctttttgcgt taagcgctcc tctaaaaatc cctggaaaac 2157661 cgagtacatt attaacagaa cgcccgtcag ctgcatatgc ggcgccagcc tgcagtgcgg 2157721 cctccggctc aatttccggc ttcggattcg ataaagccag aatcacttga ccagaacgta 2157781 caaatgccgg ttttattaaa cccggaacgc ccgttgtagc aatgacaata tcacatgttt 2157841 ccataagctc ctcaatactg gaaactgcct gtccgccgta ttgttcgaga cggttcattg 2157901 ctgactctga tttgtctgtt ccgtatacag cattcacacc ataagccatg aacatccggc 2157961 agatggccac gcctgctgcg ccaaggccga tttgccccac tttcgcttcc ttcaggtcaa 2158021 cccccgcact cctgcatgcc gaaatggcag ctgccagcgt cactacagct gtaccatgct 2158081 ggtcatcgtg cataacaggg atgttcagct cctcttttag gcgatcctcg atttcaaaac 2158141 aatgcggcga accgatatcc tcaagaagga tgccgctaaa gcccggagaa atatgtttta 2158201 ctgttttgat gatttcttca ggatcactcg tatcaagcag tatcggaatg ccgctaatac 2158261 ccgccagctg atcaaataaa gcagcctttc cttccatgac aggcatgcca gccacagagc 2158321 cgatattccc aaggcctaaa attgcggttc catccgttac aattgcaaca gaattgctga 2158381 tcgttgtata aatagaagct ttttcaggtt ctttttcgat cagtcggcac acgtccgcaa 2158441 cacctggtgt gtagacacgt cccagctctg ccagtgaacg gatcggcatt ttgcttttca 2158501 tttggatttt tccgccttca tgtgcggaca ggacttcatc agatacggtg tgaagcctga 2158561 tcccttctcc gagggcctgt acagccgcga tcacttcctg aagctgttct tcattctcca 2158621 cttgaacggt aatattccgc attgtgtaat tgggtccgac ttttaccgtc tccacttcac 2158681 caatatcccc gcccagaagg ccgatggccg tagccaccct tccaagattt ccgggaaccg 2158741 aaggcgtttc gatcatcagt gtccgaatca tgtgtttcgc tatcattcag tgatcctccc 2158801 ctattagcct agtttttcgg ctttaactgt attgtttttc gtataccata taaattttcc 2158861 tgtataacca tagataattg caagacctat tgctacaaaa ctgagccaca taaacggcag 2158921 ataagagaag gtagaaacac ctaaaatacc agccatgtaa atcccattat cagaccaagg 2158981 aaccatcccc gaagtcaatg ttcccccgac ctctgagtta cgtgataaca ctcttctgtc 2159041 cagatgtaag cgatcatagc tgtcttccat aattttcgga gtcaaaataa gagatacata 2159101 catcgcacag ccgaagatgt ttgctaaaaa cgctacgatc agtgtagaca atgtgacatt 2159161 gccggctgaa gttaatttct tttcaaacgt tgaaacaatg acttttaaca cgccgagttt 2159221 ctcaagcaga ccgccaaaac caaggccaaa gatgatgacg acgagagaat caagcatacc 2159281 gacaattcca ccgcggttta acaagccgtt caaaaattca acatccgttt taatagagaa 2159341 gccgttgtac gcagttgcaa tcgcatgggc aatatccatt ccttggaaaa caacagccca 2159401 gattgcaccg agtaaagcgc caattacgat aactggcata gatggctttt tcatcgccaa 2159461 taagactatg acgagaactg ccgggatcag catccaaata tgaatgtcaa acgtgttttg 2159521 caaagatgat tttaagaatt caactttatc aagatcaata tttttcccgc cgtacataaa 2159581 tccaacaact gtaaagagta tagctgtaat gacataagca ggtattgata aataaagcat 2159641 tgctctcacg tgagccaata catcgacttt tgatagtgaa gaagctagaa ctgtactgtc 2159701 agacagcgga gacagcttgt ccccaaaata agcacctgaa agaatagctc ccgctactag 2159761 aggaagcgga atgcctaacc cctctccaat tgcgatcatg gcaatgccgg cagttccgac 2159821 tgttccccat gacgttcctg ttgccacaga cataatggaa caaataatta acgttgccag 2159881 taaaaagata cttgggtgaa taaattccag tccgtaataa atcaaagtcg gcacaacgcc 2159941 tccggcaatc catgttccga tgagcgcccc aactgaaacg agaatcagta cggcttcaag 2160001 gccatttgat atcccatgta caatcgcatt ttgtaaatct ttataagaat aaccgagtct 2160061 aatacctaaa agcattgcaa taaaccatga aacaaaaagc gccagctgta tcggcaagtc 2160121 gagaaagact gtaaacgata gaacaagtgc taaaaatact cctagtacaa taataatttc 2160181 aaatagtgtt ggcaatctta catccttcaa aagaagtccc ccttcatgta aaagctaaaa 2160241 cgctttcaat atatagtgca acacgtatac tatacttcct catccctatg ttgtaaacag 2160301 cttattcatc cgactattcg gagatgaata agctgtattt tatacaaatt ttatttttct 2160361 aatagttctt tccctgcgat acctggtttg gtcatctcat atgggtttaa aataatatcc 2160421 aattcttctt cagtcagcac atcatgctgc agacaaagat cccggacaga ttgccctgtc 2160481 ataattgctt ccctggcaat tctagctgcc gcttcatacc caagatgcgg attgacagct 2160541 gtgatcacgc ctgcgctttt ttctacgtat tgcttcatac gcttttcgtt ggcttcaatg 2160601 ccttttaagc agttgtcagt gaacgaacgg aagccgttgt tcatgatgct gatggattga 2160661 agcaaattaa agacaagcac gggctccatg acgttcaact caagctggcc ggcttctgaa 2160721 gcaaggcaga ttgtattgtc atttccgata acctggaacg caatttggtt gatcagctcc 2160781 gccataaccg gattgacttt ccccggcata atagatgaac ccggctgacg tgcaggcaga 2160841 gaaatttccg caagtccggc gcgcggtccc gacgccatta agcgcaggtc gtttgcgatc 2160901 ttcgacatgt tcatcatgca gacttttaat gaagctgata cctctgtata ggcatctgta 2160961 ttttgtgtcg catcaacaag atgatcagcg ccgacaagag gaagcccgct aatatcagca 2161021 aggtgcttta ctacctgttt gatatattca ggatcagcgt tcagccctgt accaacagca 2161081 gttgcgccca tgttgacttc atacaggtgc tggcgcgatt gcttgattcg tttgatatca 2161141 cgctcgagaa cacggctgta agcttcgaat tcctggccaa gacggatcgg aaccgcatct 2161201 tgaaggtgtg tccggcccat tttaataaca gagtcaaact cctgtgcttt ttgcttaaac 2161261 acactatgca tatcttccat tgttttcagc agtttttcta agagcttcaa tgtggaaata 2161321 tggatagcag tcgggaacac atcgttcgta gactgtgaca tgttcacatg tgtgtttgga 2161381 cttaaatgga tataatctcc ctttttatgt cccatgattt caagcgcccg gtttccgata 2161441 acctcattcg cgttcatgtt catagaagtt ccggcaccgc cctgaatcgg atcgacgata 2161501 aactgatcgt gccacttgcc ttccagaatc tcgtcagcgg cttgtacgat agcttggcca 2161561 attccttcat acagccgttt cacgtccatg ttggcaagag ccgcagcttt tttcacaatc 2161621 gccagtgcgt taatcatttc ctcatggatt ttgtatcctg tgatcggaaa attttcagaa 2161681 gcacggagcg tctgaattcc gtaataaaca tctgcttcaa tttgtttttc cccaaggaag 2161741 tctttttcca cgcgatattc tttttggccg tttaacataa tctttaacct tctttctctt 2161801 tgctggttat cgtttttaca ttttacagga caacgtcatc agctatcggc gtttccataa 2161861 ttctcttgac gacaggaaga tccgaagact gacctagcgc ccacatcaat tttggcacaa 2161921 ttgcttctgt gttcatattt cttgatcgga taattaagtc ttggttgact ctgcggccaa 2161981 cctcgtaaat gctcatgtct tcgccttctt caagacattg agtcgtaatg acgacgacaa 2162041 tgccgctttc gatcagttca ttcacttttg acaaaatgtc tctgccttca aacggcactc 2162101 ctccgctgcc ataactctca atgacaattc ctttgtacat gcttttcagg gcatcaaaca 2162161 tttcgggctt taagcctgga tgcagcttca gcagacatac atctgtgcat agtgaagtgt 2162221 caactgtgaa ggtgtcgttc tcaggttccg ttacttgttt gttgtattcg atcccgtctt 2162281 cattgataaa agcgatatat gggtaattga tgctttcaaa tgcgtcgtag cttttcgttc 2162341 ttaatttgat cgcacgcgtt ccctgaatga ctctgccgtc aaacacaaca taaacgccgc 2162401 ccacgccttc acaggcaaat cgaatggcat ctgtaatatt ttttttggca tcggtttttt 2162461 ggaacgtgat cggaatctgc gagccggtga tgacaatcgg ctttttggca tgctgcagca 2162521 tatacgatag tgcggcagat gtataggcca ttgtatctgt accgtgagta ataacaaacc 2162581 cgtcataggc atcataattt tccttaacgg cttctgctat ttccacccag tattcaggct 2162641 gcatattggt gctgtctata ttcataagcg actgagtttc cattgtgtaa tcgttatcaa 2162701 gttttgatac gtaacttaat aattcatcag ccttgactcc gggagccagc ccattttccc 2162761 cttcaactga agcaatcgtt cccccagttg tcaacatcaa taattttttc ataccatgca 2162821 cctcttcact gtatctaaag atgggttgcg agaaggtatt cgcttttcgc atacttttaa 2162881 tgcaattata gacacggaaa ataaaatacg caagacatta ttattcaatt cgcgtacact 2162941 tcctaatacc tatatgatat aatcagctca aggtgaaaaa ggagcggaag ttcatgaatc 2163001 tagatcgttt aactgaattg agaaaaaaga aaaattggtc gcttcaatat acagctgacc 2163061 ttctcggtat cgcaaaaagc acatatgccg gctacgagtc aggctaccga cggccttcac 2163121 ttgaagcgct tgccatgctg gctgacctct ttgacacaac ctgcgatgaa cttttaggcc 2163181 gcgagaaaca aaagcagact gctcctcagg ccatagaatt ggccacgtgg agcagcctcg 2163241 actttaccat ttctgttgat ggccagccgc tgagtgaaga tgaaatcatc cagctgatta 2163301 cctttatacg cacaaaaaga aaagtacagg aggaactgag ttaatcttta gctcacggtt 2163361 taattttacc gtaggttcct cctcctccgg ctttcaattc cagttttccg gatctcgctt 2163421 ttacgataag cgccgcggtt ttcggcggga caacgcgagc caaatcttct tctgcagcct 2163481 catgaagaac agccatttct gttccgaagg ctttttttag tttgtccagc gttttcgggc 2163541 ctacacccgg aacaaattgc agcgggatct gatgtacata tcgcggacgc gggacgcgaa 2163601 cttcaagctg atcactcaat tcacgcaatc tatcgctgac tcccttggta aatctggctt 2163661 ttccgcaatt cgcgcacgct gtttccccgc ttacagcagg ctctccgcac gcttcgcaag 2163721 ccgtctgata atatttcccc aataacgggt ccaagccata atttgcgata attttcctgt 2163781 catcttgtcc ctttaatgca agagcaaatt cagtaaaatc agctgactgc acatataatt 2163841 cattatattc tctgccgatt ttccccaacg aatgcgcatc agaatttgtt aaaaaaggat 2163901 acggattcaa ttgcgatacg tgtgatgcca tgtctgtatc acagcttaat ccaagctcca 2163961 ccgcgtctat catagatgga tcaaaaacct cagttaagct tgatttaacc ccttttccat 2164021 ataagctttt atgcggcgta aagatatggg cggggataaa caggccgccc atatcctgca 2164081 cttttttttg caggtttaag cccgtttcat aaatccgctg cgagcttaaa tgaatatttt 2164141 tcagccgggc tgacagccag tttgaaaact gtttcatatc agccagcgtc ggcataaata 2164201 cgagcacatg gatcggtccg ctgcaggctt catcataaat ctccagctcg ctccccaata 2164261 aaagagtcgt gctgcgataa cggattcctc ccccgtcaag ctcgcgatat tttccagatg 2164321 aaatgccttc ctcaagctct agaatgactt ccggagaatg acagtcgata atgccgagga 2164381 gttcaattcc tttatgttca ctggcttcaa ccaaaattct gtccagcgtt aatgttttgg 2164441 cgcctgttat tttgacagcc cttcctgtaa aggtccggcc gatatgaatg tgcaaatccg 2164501 cgtaaatctt tttcattttt gtgcttggag cgcttctttc agctgaagat actgaatcgc 2164561 gtaggctgtt ttagcatcat atacttcacg cgattcaacc agctttagcg catcttcaag 2164621 cgtcacctcc atcacttcaa caaactcgtc ctcatcaagc tcccgttttt cttcaagcac 2164681 agaaagctcc tcagcaagaa aaacgtgaac gatttcatct gcaaatccgg gtgatgtata 2164741 aaacgcagtt atttttgtca gtttttttgc tgtataaccg gtttcctctt caagttcccg 2164801 aagtgccgta tactccggct cctcaccttt ttcaagctta ccggccggaa tttcaacgat 2164861 cgtccgctca agcggcttac ggaattgttt gaccatgatg attttccctt catctgtgac 2164921 ggctagtacc gctacagctc cagggtgttt cacaatttca cgtttactgg ctttgccgtt 2164981 tggcagctct acatcctcga cataaagatc aatgacttta cccgaaaaaa tctgttcttt 2165041 ggcaattgtt ttttcttcta atgatttcat ttcttcatct cccgttctgt ctctatatga 2165101 tgccccatac attttatcat actagagcaa aagggggctt cttcgtgaaa gtgcaccgca 2165161 tgccaaaagg tgttgtctta gtcggaaaag catgggaaat tcgagcgaag ttaaaagagt 2165221 atggacgcac atttcaatat gtgaaagatt ggatctcaaa gccataaaag ttgaaacttt 2165281 agctccttta tattacggtc aatacaaagc ctaaaaaagg agtgtgcaca tgagaaagcg 2165341 caaattgggt acatctgatt tagacattag cgaagtcgga ctcggctgta tgtctcttgg 2165401 aactgaaaaa aacaaagcat tgtccattct ggatgaagcg atcgagcttg gcatcaacta 2165461 tttggacaca gcggatttgt atgaccgggg acgcaatgaa gaaattgtcg gtgatgcgat 2165521 ccaaaacaga cgccatgata ttattctggc aacaaaagcg ggaaaccgtt gggatgacgg 2165581 aagcgagggc tggtattggg acccttcaaa agcttacata aaagaggcgg taaaaaagag 2165641 ccttacacgt ctgaaaacag attatatcga cctttatcag ctccacggcg gcacgataga 2165701 ggacaacatt gatgaaacga ttgaagcgtt tgaggaatta aaacaagaag gtgtcatccg 2165761 ctactacggc atttcttcca tccgcccgaa tgtgattaaa gaatatgtaa aaaaatcaaa 2165821 catcgtcagc attatgatgc aattcagcct gtttgacaga cgccctgagg aatggctccc 2165881 gcttttagag gaacatcaaa tcagcgtagt cgccagaggt cctgttgcca aagggctctt 2165941 aactgaaaaa ccgcttgatc aagcttcaga aagtatgaaa caaaacgggt acttgtccta 2166001 ttcattcgag gaactgacaa atgcccgtaa ggcaatggag gaagtggctc ccgatctttc 2166061 catgacagaa aagtcgctgc agtatctgct agcacagccg gctgtcgctt cagtgattac 2166121 aggcgccagt aagattgagc agttacggga aaatattcag gcagcaaatg cacggcgttt 2166181 aaccgaagag gaaatcaaag cgctccaatc tcatacgaaa caagacattt acaaagctca 2166241 tcgctcatag cagaaaaacc agcacctgta cgggtgctgg tttatttata ttgatgccaa 2166301 tccatttggc tttcatttag gagttcttca aagctcttat ttttttcgat ctcttttttc 2166361 tttctaatct gttctgcttt ttctcttttc tgcctctttt catcctcttc cttcaattgg 2166421 ctcttcatct ccataagctt tgctttgata tcggattgaa ggccgtcttt tagctggtgt 2166481 ttgtcaatgg atttttgttt tttcatgcag acttccccca tgttttgttt tgaagccagt 2166541 ttatcacgga gcatataaac tgaacaagca gactctcttc tgatcacttt ctcagcgtag 2166601 cagtgtttag gtataatgat cttaaacacg aattgcctat atatttcgtt gaaaggtgct 2166661 gtgacttttg aagaaaatcc ttttggccat tggcgcgctc gtaacagctg tcatcgcaat 2166721 cggaattgtt ttttcacata tgattctatt catcaagaaa aaaacggatg aagacattat 2166781 caaaagagag acagacaacg gacatgatgt gtttgaatca tttgaacaaa tggagaaaac 2166841 cgcttttgtg ataccctccg cttacgggta cgacataaaa ggataccatg tcgcaccgca 2166901 tgacacacca aataccatca tcatctgcca cggggtgacg atgaatgtac tgaattctct 2166961 taagtatatg catttatttc tagatctcgg ctggaatgtg ctcatttatg accatcgccg 2167021 gcatggccaa agcggcggaa agacgaccag ctacgggttt tacgaaaagg atgatctcaa 2167081 taaggttgtc agcttgctca aaaacaaaac aaatcatcgc ggattgatcg gaattcatgg 2167141 tgagtcgatg ggggccgtga ccgccctgct ttatgctggt gcacactgca gcgatggcgc 2167201 tgatttttat attgccgatt gtccgttcgc atgttttgat gaacagcttg cctatcggct 2167261 gagagcggaa tacaggctcc cgtcttggcc cctgcttcct atcgccgact tctttttgaa 2167321 gctgagggga ggctatcgcg cacgtgaagt atctccgctt gctgtcattg ataaaattga 2167381 aaagccggtc ctctttattc acagtaagga tgatgactac attcctgttt cttcaaccga 2167441 gcggctttat gaaaagaaac gcggtccgaa agcgctgtac attgccgaga acggtgaaca 2167501 cgccatgtca tataccaaaa atcggcatac gtaccgaaaa acagtgcagg agtttttaga 2167561 caacatgaat gattcaacag aataaaaaag cgaaaggcct cttcggctct ttcgcttttt 2167621 tatgttacag aacgtcggta atgccatcca tattttctct gatccattca atcgcaagat 2167681 ctatcgttgt aaactcctgc gtctcgaagg tcatttcatc ctgcaatagc cagacatctt 2167741 tcttgatgga ctctgctcct ccgattgacc agtgaagcaa ggtataagga tggttttgat 2167801 tcaggaagga tacccacgtt ttattttgtg ctgtgttctt cattgccttc agcttttgtt 2167861 ccacgtttcg cgtctcctac tttactaata tgctcattct ggggctgagc atttcagccg 2167921 ggcttttcag cgccaatgtt ttggcttttt cattgtaatc gatcgtcatt tgatcgtcaa 2167981 aaaacacttt ttgcgacgat tggatataca gcggaatgcc gttcgtttcc agctgctcgc 2168041 actgtcccgt taattcttct gccagccaga ttgtcgggac accgcttacc gcgcagccgc 2168101 atccttctgc atcgtaacga agctgggctt tttttcccgg gttggcgtca aacgcctgct 2168161 gcagtgcctg ttttgctgca tctgtcacat gtatgttcat aaggtgaaac ccccgttttc 2168221 atcattttcg ctattgtagc atacaatact gccattcgca ttgtttctgc cttttttcca 2168281 ccgcttcgca ttttcttctg cagtcttgat ccactcatct ttcccttgta tatactgatt 2168341 gatgctgtca gggtgctggg ccgccagctg ttttttgaga acggcgtatt ctttcgctat 2168401 gtttggatga gctctgagat aatctctgaa taacagatgc ctttcaatag cagggtttcc 2168461 ctgttcgtac atatggacat gatgagtgcg tttatttccg cccttttgga aataacgcct 2168521 gcccgctata ccgttctcac cttttggtgt atagccgttg gccttcattt gttcatcaaa 2168581 ttggctcacg gcttcaatgc ttctgacttc aattaacata tcaatgattg gcttcgctgc 2168641 catgttaggt attgatgtgc ttccgatgtg atgaatagcg ataatctccg gcccgaacac 2168701 aagtttcagc cgttcttttt cttcatcgaa acattctgcc catttttcgt tgtagagaat 2168761 gatctcaact tttcttttcg gatacaaatg aaagaccgac agcaatagac cctgcgctgc 2168821 tttgacggtt tctgcctttt ggaatccggc ctgtgtatag agtgacacag ccggggtatt 2168881 gttctcggct gtgactactt cgattttctc agcgtcttca ttatgatcaa tgacaaattg 2168941 cagaagcgct cgtccaattc cttttctgaa accgtcagga tgcacaacaa gcctgcaaat 2169001 ggtgagataa tgcatgtttt tctcatatga aatgacaccg atcagcttgc cgtttttccg 2169061 atatcccgca aaccgttcat gggatgcttg aatatccttt accttctctt gtaaagcggg 2169121 aataccgtca aaaccgataa tctctgtttc ctttatgtag gcggggatct gtacggctaa 2169181 aatctcacgc gctatagtgg cttccttatg ctggagaaat tcaatcattc gtgttctcct 2169241 gaaacagccg ctgtctgtcg acttttgcga cgcggactgc atacgactcg taccaaacgc 2169301 ttcttccttt ttcttttgct gcttgatgtt cagtgtgatg cctccaatgg ttaattgcgt 2169361 ccatactgtc ccaataggaa actgtgatgc cccttccatc cgcttcacgt acgctttcca 2169421 cgcctaaaaa tccaggctga tccgccgcaa gtgataccat ccgctccgct gtttctccat 2169481 atcctgtgtc attttcgctt ttgacagaag aaaaaatgac tgcatagtaa ggaggctcag 2169541 gtgtttttga taaaaaatcc atcatatttc cccctcatat gtttttgaca aatagtaccc 2169601 tgtcttggcc cgggccatca tagtttgcaa acactgagat gccatttacc gttttggtgc 2169661 ccttttcaat atcaaacccc aattttgtgt gatatgcgat tgatacctta ttcacaggtg 2169721 aagtgacaca cttcacccgg gtgcagcccc tttgttttac tgtttcgata aatacatcat 2169781 acaattgttt cccaatttgc atttttctga aatccggatg cacaccggaa aaatgaatgt 2169841 acgccgtttc aggatcggat tgcgattgaa atccgattaa aaatcccgtc atgctgttat 2169901 gttcggatgt aataaagctt gtgtcctgaa aatgctcaaa aaatagtctc ggcaattttt 2169961 ctttcagctg tctgccgccc caccattcat tcagtacaga cgttaccatt tcataatctg 2170021 aagacgtgat tgttcgaata tccattacga tttgatctcc ctccgtctgg caaaacgaat 2170081 gtcagctctt tttctcacaa tataaaaatt atattttgcc tggctggaat tgtaaatgcc 2170141 ttctttcctg tatcatacgt ttccagactg ccgagggaac aatgtttgat cattttacgc 2170201 ctatttctcc cccaaacagg aggagagact ttacagcaca atatcaagca cttgatcaag 2170261 tttcagctta taaagctgat cctcgtctcc ttttatccat actgcttttt caaactcttc 2170321 ataccggcag attttcccgg tgcagcagac aatctcaccg tcctgaaagc agctgacagt 2170381 gatatcctga gcaaactcca tcgcggcgca aagcgtttga ttcatctctt ccagcttatc 2170441 ggggtcaagg atcggctttt gcagcttctg tttaagtcgc tttctctcca gcaggctttg 2170501 cttatgttcc ggcagaaaca tcctgctccc ttcccacagc aggttgcccc tttttaaatg 2170561 gtcgttcatt tataatgccc ccctatttta gccgcacgtt caaatgcctg gcctgccgct 2170621 gtcagtgacg ccgccctgat gattgctgta tcgccgaatc gatttttaat gccatccatc 2170681 acatagccta ggctcatttt ctttgcataa tcctgaaata aattgagctg ccatatgtca 2170741 tcagatgaga gctgagacag attgacaccg aggcggcgga cgggtttccc gtcccaaaat 2170801 gtaagaaaca gccgtcgtac agcctcatat acatcctgcg tagaattagt cggctctgcc 2170861 agcttcactt gccggttgaa gcccgtcggc caatcaaaat cagcaccccg gcagctcact 2170921 gacactgtct gccccatgac cccggcgttt cggcttcgcc tgcacacctc ttcactcagc 2170981 tcaagcaata cgaccttgat ttctttgtca aagtgttcgt agtctctcgg gagagtcatt 2171041 ccatgaccta tcgccttttg cccgtccaga gacgaagttg acacagggga atagtcgatt 2171101 ccgtttgccg tcatccacag cacgtggccg ttaatgcccc atttcttttt taaaagatcg 2171161 agcggaaaag ccgcgagccc gccgatcgtg ctgatgccca ttcgatttaa atgatgcttc 2171221 atgcggctcc cgacgccaaa catgctgccc accgggagcg gccacatttc ggttttcata 2171281 ttttctttcg ttaaggtaaa aataccgttc ttattctttt tggcaaaatt gtcacacgca 2171341 attttggcca gcgctttgtt agggccgatt ccgacccgtg cataaacgcc gatctcccgc 2171401 atgattctgc cctgaatgct tttcgcgatc tccatcggcg tcccaaacag cttctggctg 2171461 cctgtaatgt ccatgaactg ttcatcgatg gaatacggct ccacaaggtc tgtatactcc 2171521 tcgagaatgg ccgtaatttg cagtgataca tcaatatacc gctgcatacg cggccggagc 2171581 acaacagcct caggacactt ttcctgcgcc tcccacagcc gtgaagcatt caccacaccc 2171641 ttttgtttcg ccagcgggca ggcagccaat acgactccgc cccttttttc agggtcaccc 2171701 gaaacaatga cgggcctatt tttcaaatgt ggattttccg ctttctctac agatgcataa 2171761 aacgattgca tgtcaacgag aaaaatcact ttttctttca tcatacacac ctctaaaaag 2171821 aacttatgtt cgcttttcat tatatgcgaa agtatgttcg ttttatactg gtaaatgatt 2171881 cttgtctgac agaaaatatg atccaagggt ttgagagaag aaaaacattt agtagaataa 2171941 aagcgaagca taaggatagg agagtcatga tggagaaatt tgtcgaaaaa atgctgggac 2172001 aggcattgcg gcaatacggc agaaacgttg ctatagatcc gttaagcccg tatgaaaaac 2172061 aaagcctgaa agcggctcta caagagagac ggaatgaaga accagatgag gatttgcatg 2172121 cgcatataga agatatcatt tatgactatg tcacaaacca aggcctgttc tcttaaacgc 2172181 atgactgtca gttctttcag ccgctgatgc ggcttccctt tgaaaacacc gcctgaaaca 2172241 aataaacagt ctcaggctta cagaaaaaaa gcaggatttt ctcacgctcc atagattcat 2172301 atggcctggc gtaaaattcc cctcaatgct cgcgcaaaac ggaataagct gtccatgatc 2172361 acgcgtatac actttttcga agagatgtgc tctcttgttc tgtcatgcgg tccatgccgg 2172421 ttttcagcgt acatcttgat ctcatagccg gtttcactgc cgatatgatc cacgttctgg 2172481 cggcttaaac taacacaccc tcactgacca atcgctttgc ttttcatcgg acatcccgtc 2172541 attttccttc tttcaagatg taaactccgt cagccacacg catcctcaac gcatagtata 2172601 ttgccatcca tacaatcagg catactacat gtcaataacg aaatattttg aacgatctat 2172661 tggagaagga aattttttca tatatgatag agaaagatca tacatacagg agagaatata 2172721 attcatgaag aaatggaaag atatccaccc gatcagctgg acaattataa tcggaaccat 2172781 tttcggcaga atggcaacat cgatgagcat tcctttttta gcgatttatt tgacagccgt 2172841 ccaaggcgca tcagcttcct atgcagggct ggtcatcgcc gcgagctcat cagtcggcat 2172901 cctcgcaagc ttttacggcg gatatatctc agataaattc ggcagaaaaa acatgatgct 2172961 tgtatcgatt ttcggatgga tgctggtatt tgcaggcttt gcggcagcat ctaatctctg 2173021 ggtgtttttt gtagtaaacg cattaaacgg tctttgcaaa tcactgtttg agcccgcttc 2173081 aaaggccttg ttgtctgata tgacagaaga aaaaacgaga ctgctagttt ttaatttacg 2173141 ctatgcggct attaatatcg gcgttgtctt cggacctgtg cttggcctat atttcggctc 2173201 atcgcaatcg actacgccct ttttggtgcc tgcagtcatt tacggactat acggaattgt 2173261 gcttgccctc caatttaaaa aacatccatc cttatcagca ccagcccagt cccgaaatat 2173321 gagcgtgcgg gaagcgttta tggtcacgca aaaggattat ctttttacca ttgctttggt 2173381 cggcattacg ctatgcacct tcggctactc acaattcagt tccacattcc ctcagtatat 2173441 ggcgcagaac cccttgatcg gcaatggaac gaagctgtat gggctgatgc tgacattaaa 2173501 cgcaatcgtt gtgttggcga cgcaatttcc cattgtccat tttgcaaaac ggttttcgcc 2173561 gctttgttct ctgatgctcg gtaatgtgat ggttagcatc agcatggcca ttttcaccgt 2173621 atcacacggt gttccatcaa ttgtgatgat tgtcatcaca tttacaatcg gcgaagtgct 2173681 tttattctct atgatggatt tgtatgtaga ccagattgca aaaccaggat taaaaggcac 2173741 ttatttcggg gcaatcggtt tttcacagct cggaaacgtc atcggccctt gggtcggggg 2173801 gatatgtata gacctgtttg gcgctggccg gccgatttat attttttctg tcctgagcgg 2173861 cattaccctg ctcggcctgc catttttagc gttcgcctat cggcaaatga aaatggagac 2173921 cacaaaacac cgttcccgtc tggaaaagcc gctttaaata aaaaacggaa gagaatgaat 2173981 ctctcccgca aacatgaggt gaagaacatg aatataggtg atgtgatgtt tcagctgttt 2174041 gtatttatta tatttgccgc tgtcgtcttt gcggctgtta caggcttcaa gtatgcgaaa 2174101 aaccgaaaag cgcagctgga tcgcattgag aaaaagctga acagcctgtc cgaagatcac 2174161 gattaacagc ttggggcaac gagctctacc ttaatccggt ctggatcctc acaaaagact 2174221 gcataatgcc cgtctcctcc ggcaaaagga tgcctgtctc ggtacaacac acgatagcct 2174281 tttgccgtca atttttcagt catctgatcg acttgaagct tggattcagc atgaaatgcg 2174341 agatggttca gaccgactcg gcatctatgg tattccggct ctagaaatgg ctctttcgcc 2174401 tgcacaatca ctaggtaaaa acgatctttc ttccagctga tgcctgagct ccatttttga 2174461 tactctttat aaccaagttc ttttaagaac cagccccaaa accgcctaga cgcctccaaa 2174521 tcagagacat acagttcaat atgatgcaca tttcataccc tccttaccaa cacttcctcg 2174581 accttatgcc cgtctccctt acgcaaaatg agatctgacc tgaatttagt tggcaaaata 2174641 ttttcatata aattcggccg gttgacactc tcccaaatcg aggctgccat ctcgtcagcc 2174701 tcctgatcgg acaagtcttt aaatttatga aaatatgaat caggattttg aaaagctgtt 2174761 tcccgaagca ggcgaaaacg ctctaaatac caagtgaaaa tccggctttc ctccgcatcc 2174821 acataaatcg aaaaatcaaa gaaatcggaa acaaaaatac gcgggttttc ccggtcatcc 2174881 tccaaggtgg gcgactgaag aacattaatg ccttcaataa tcacaatatc cgcctgttct 2174941 acaacctcga acacaccttc ctcgcggtca taggttagat gggaatacac cggggccttt 2175001 acgctgtcct ttcctgattt taagtcattc aaaaattcga gcagcgcctt tacatcatag 2175061 ctttcaggaa atccttttct tgacatcata tttttctttt tcagctcggc agtaggaaat 2175121 aaaaaaccat ctgtcgtgat aaggctcact tttggacggt caggcaaacg cgaaagcagc 2175181 ttctgcaaga tccgcgccgt cgtgcttttt ccgactgcga cactgccggc aatgccgata 2175241 ataaacggaa ttttggctga atgtgggtgc ttcaaaaaaa cattgacatg cttattgcgt 2175301 tcagccgcag acttgacatg taaatgaagc aagcgaacaa gcggaatata gatcgtctcc 2175361 acttcttcaa cagatagata atcattcaat ccttccacag cttttgcctc ttcttcagat 2175421 acagcaatcg acaaatgccc cccaaaacca gaccaagact cccgattgtg ctgtgtatat 2175481 aaagtatgta ggttaagttc tttatttttc actgtttaca cctgactctc tgtaggttaa 2175541 aacccttaca aagattgtaa cggaaaacct tttcactgtc tgcttatttt tcatttcgtt 2175601 tttttagcaa atcagcaccg attcggttat acgcagccat ttcatctttt ggaaccatgc 2175661 ttcctcccgt tccccagacg acatgtacgg catgttccat cttatatttc tgagcatagc 2175721 gccttccctc ttctgtcgaa aaaagctgaa ccggcccgaa catgccagca agagcagagg 2175781 gctctaaata tttatcttca gatacagcca gcatatgaag caaagtataa agcgtattgt 2175841 cctctaccgt ataacagccg ctcagaagcg gttcaatcag cttgccgaca aatcctgacg 2175901 gcctccctac ggcaagtccg tcagcagccg tctgattatc caggccgata tcctggacgg 2175961 agatcttctc gtgaagtcct gaataaagcc ctaacagcat acaaggtgaa tgagttggtt 2176021 ctgcgaaaaa cacatgaaca tcatctccgt ataaaagctt cagcccaaat gctacaccgc 2176081 ccggtcctcc gccgactccg cacggcagat acacaaacaa gggcgtctca agacttggct 2176141 ttatattcat acagtcaagc tgtgttttta atcggcttgc agcaacagca tatcctaaga 2176201 acagctgacg agaatgttca tcatcaataa aataacagaa tggatcttgt tccgcctgcc 2176261 gtctcccttc gttcaccgct tcactgtaat ctgtttcgta ctccataaca gtgactccct 2176321 tttggcggag gagatccttt ttccactgct tagcatcggc ggacatatgc actgtcacgc 2176381 gaaacccgag tgccgcgccg atgatgccga tgcttaaacc tagatttcct gtcgaaccga 2176441 cagcaatcga atagcgggag aaaaacccgg taaaccgctc ttcctgtaag atgcggtaat 2176501 catcggtttc ctgaagcatt ccttcttgaa gcgcgagatt ttcagcatac tttaacactt 2176561 cataaatccc gcccctcgct ttaatcgatc ctgaaatcgg aagctcatgg tcgcacttta 2176621 aaagccatct tccgggaaat ggctgctgat atgccgcttc cagctttccc ttcatatgct 2176681 gcacctcaaa aagcggagac tcgatgattc ctttagcgcc tttcgtctca ggaaacacct 2176741 cggcaatgta aggtgcaaac cgctgcattc ttttttccgc ttccgctatc tcggttgccc 2176801 actcatctgc acggggtaat ggcccctctt tcttgcctga atttgcccag aatacaggct 2176861 ctgcatcaat cagtttctga ataaacggat ctttaagcag agcatgaagg acttctgaat 2176921 gaactgacat tcaacaatct ctcccttcca ctatcaaaaa ctgccccgtg agaaacaagc 2176981 cactccacca caggcagttc tatcattatt ttttcatgag cgcgcgtcct gccagctttt 2177041 ctacaagagc tggaaacagc tgatacagct tagtgccggc attcattaaa cgcggaagat 2177101 tgatctcccg ctttttcgta aaaattgcag ctgtaatttg agctgccacg tcatcaggat 2177161 caagcatcca gcggccgaca tttttggcgt agtccccgcc tttatcagca atggaaaaaa 2177221 agtccgtctg aatcgggccc gggttgactg ttgtcacata aatgccggtt cccgaaagct 2177281 ccatccgcaa agcgtttgag taacctaaca cggcatgttt ggtcgcggaa tacaggctag 2177341 acttcggtgt ggcgattttc cccgcttgag aggcgatatt gatgatatgt cccttttttt 2177401 gctcaagcat ttgcggaagc accgcttttg tacaggcgat caggccgaag acattcacat 2177461 caaacatcgc tttcatgtca tccaatgtag agtctaaaac cgtttcaaat ataccgaagc 2177521 ctgcattgtt aatcagtaca tcaatcgagc cgatctgatc gcggacccgg gcgatatcct 2177581 ctaggcggcc gacatccaga ggaaaaatct cacactgtcc gctccattcc tcggttattt 2177641 tccttttgat ttctatcaaa cgatcctcgc gtctagccga cagcaggaca tgggctcctt 2177701 cagccgcgca taagtatgcg attctttctc caagccctcc tgaagcgccg gttatccaaa 2177761 tcctttttcc cgctatatgt ttcacccatt tcacctcttc attgttttaa agtatacggt 2177821 atttccttcc caatatgacg tgatggcttc ttcagcctcc aacacatcaa ggtgacctgc 2177881 cgtttctgac atcgttaaaa acaattcctt ttcatataca gcaggaaaaa gctgctgaca 2177941 gacctgaaaa gcggtcatcg gcttttcatc cagcatgcga cgcacatcct ccgtcctgtt 2178001 cctctgcttg tcaaaacgct tctcaatcag cgcttgtaca ctggtgatag gctcgccgtg 2178061 accaggaaat acgattgttg gatcaagttg agacagcctt cgcaatgacc gctgataatc 2178121 cactaaaggc tttgacctga cgtctcccgc tttcggcgct tccaaaatcg gattagacga 2178181 gctgtttgcc agcagtagat cgccgccaag catccttccg cttttttcat ggaacagaac 2178241 aatatgcgat tcagcatgtc caggcatctc caacacagac cagccctcaa gcccatctat 2178301 gcccatacct tctctgattg attttgtcag agatctcgta caggaaaatg cgtacgctga 2178361 tcgaatcagc ttttccgcct tccccgtatc aaatggaacg cctaattcag gcagcagctt 2178421 ttgaaaaaaa cgtttttgcc aatccataaa ggcttgattt tggctgatat aaggttcgtt 2178481 gaatgtatgc ccaatcactt cgatttcatc tgaaaagaca tcaagcaagc ctgcatgatc 2178541 agcatgatgg tgagtcagta caacctgctc gatatctgac aatttcacat ttacagcggc 2178601 aagctgctct tgtaaggctc tggcagcctc ttttgtattc ggcccggcat cgataagtgt 2178661 cagcgcatca ccttttacga ggtaaacgat aacatcgccg acagcaaacg gtgtcgggac 2178721 gcggatcgca attacatctt cagttgtcat cctttcgctc cttgtcttca ttcattattc 2178781 atattttagc tttttctcgg tcttgtgtca ttattgcaga atgagaacaa acctttttga 2178841 aaaagctatt gacattagct tgtccgccat tgcataatga acaacaaact aaaacgagaa 2178901 ccattggaac gctatgacga ggaatagtat acaaggcaat ggcctaagag agcgataccc 2178961 ccggctgaaa ggtgttgcgg cccgcttgtt tgtagaacct gccctcaagt cgcggttagg 2179021 aaaacctaaa cgtttcccgc gttacgggga tttgagctga gcacaatttg tgctaatgag 2179081 ggtggtaccg cgaacctttt cgtcctttac gtgatgaaaa ggttttttgt tgttctaata 2179141 gaaggaggat atcaatgaaa aagataggat ttgtcggcgc cgggtcaatg gcagaagcaa 2179201 tgatcaacgg cattttgcaa agcggcatca caaaaccaga acatatctat attacaaatc 2179261 gctcaaatga cgagcgtctg attgaattaa aggaaacgta cagcgtgcgt ccatgcagag 2179321 ataaaaatga gtttttcact cacaccgata tcattatcct cgctttcaaa ccgaaagacg 2179381 cggcggaaag catcgacagc atccggccgt atatcaagga ccagcttgtc atttcagtac 2179441 ttgcaggcct taccatcgaa accattcagc attattttgg cagaaagctc gcggtcattc 2179501 gcgtcatgcc taatacatca gcggcaatca gaaaatcagc aaccggattt tccgtaagca 2179561 cggaagcaag caagaatgat attattgccg caaaagctct attggaaaca atcggtgatg 2179621 caacactggt tgaggagcgg catcttgacg ctgtcactgc aatcgcaggc agcggcccgg 2179681 cctatgtgta tcgttatatt gaggcgatgg aaaaagcagc acaaaaagta ggattagata 2179741 aagaaacggc aaaagcactc attttgcaga caatggcagg ggcaacagat atgctcctcc 2179801 aaagcggcaa acagccggaa aagctgcgta aagaaatcac cagtcctggg ggcactacag 2179861 aggcaggtct tcgcgcttta caggactccc gctttgaaga agcaattatt cactgtattg 2179921 aagaaacagc taaacggagc gcagaaatca aagaacagtt tgccggtgcc gccttagaga 2179981 gacattctta gatgtaagga caaaaacaga aggcacagtg ccttctgttt tttatttttc 2180041 ccgcagcagc tggccggcag attctgattg ctttaatagc gcggagatcg taaatgaaag 2180101 caaatcggga agcacttcaa aggaataagg catatacaat ctttccgtcc atttatgcgg 2180161 gtctttacca gccggaccga catttaaaac tgggacatat aaagcctgat ttttaccgct 2180221 tggcaatgaa taccctctgt taaagagcgg catattgctt gtgtatgcat caacctcctg 2180281 tttttccagc tgaagataac tcaagtccga aagtccgggg aagtactgaa cctcccgtaa 2180341 tgcaatgccg tatcgctcag ccgcataatg ctttatctga tctgctgtat ttctgatcaa 2180401 ttgatcatcc tttgaagaaa cagctggata aagcggcgga ctataaaaca gaacgatgag 2180461 cggcgcatcc tccttacaaa gcgaagcaag ctcagaaaca attttcgtcg aaaaatccct 2180521 gtctccaagc tcccccctgt tagcaaaggc ataatttaga gcccgctctg tttccgagat 2180581 ccccgcacgc ttttttgcac gcgagaccag ctcatcaaat gtcaaaacag tgacgtcccg 2180641 ctcaatcggc tgaaatggct caaattgttg aaaatcctgt gttttcttcc gaacgttcga 2180701 catgatttcc tccgccgcct gttctgctgt tttaagcagc atctgatgca gctcactagc 2180761 tgagcgtttc attgacagca cattaaataa tgtgacggct gtatgcggtg tctggactga 2180821 atatgcctct ttcaagtcct tttgcattaa gtttaccggc ggcggagtga cctcgccatc 2180881 aaccttttcg caataatcag cattcagttc aagcaaacgg ttaatctcag ataccattaa 2180941 atttgcgttt agacctgaaa acggctctcc aacatgtgtc tcaatcccct tgcagaaaaa 2181001 acccgcaagc accttgccaa tgcttcctgt ataaaaatat tgctgctgat cgccgggaaa 2181061 tttttcaaac atcggttcgg cattcaggca agcggttaat gtgatatcat gctttttctc 2181121 catctccttc aatgcaggaa ccgcttcaat catgcctctt gaattcactt cctcgtccgg 2181181 aaccgttatc aacagcagat tgccctcaaa atgcccgttc attgccctct ccagcatcga 2181241 cagttgaata caaagccccg ctttcatatc catcgtccct cttccgaaca gccagtctcc 2181301 gctttcggca tctcttctca cacgttccgg gagcagctct tttttctcta aaaaggagct 2181361 caaaagctca gcaggcttgc aagccatatg tttaaattcg ccgtaatctt ctatgtcaac 2181421 gacatcaaaa tgactcagca gaagcactgt ctttttgaca ttcttctttt tgactagagc 2181481 cgtaagaaaa gatctgccat cgtccatcgg atgaagtgtt acatcatcag ggtgcttttg 2181541 aaaatagggc ttgtccttca aaataaaata aagatactct gcaagcgcta cctcgccctt 2181601 tgaaccggtg atgctttcgt attgcacaag agaagttaaa agtgccagca attcgtcctt 2181661 cgtctgccaa ttcattgatt ccgcccctcc tatgaataaa aatgcttcta tactgaaaaa 2181721 taaactgatt tctcgtctat tatacagaaa tgtttgacaa aagcggttca tttgagcagt 2181781 ttatatgacg ggaaagaaat gacttgatat aatcaatctc taaaaacctt acgggaggcg 2181841 aaagaaatgg ccagaaaatt atttacacct attacaatta aagatatgac gttaaaaaac 2181901 cgcattgtca tgtcgccaat gtgcatgtat tcttctcatg aaaaggacgg aaaattaaca 2181961 ccgttccaca tggcacatta catatcgcgc gcaatcggcc aggtcggact gattattgta 2182021 gaggcgtcag cggttaaccc tcaaggacga atcactgacc aagacttagg catttggagc 2182081 gacgagcata ttgaaggctt tgcaaaactg actgagcagg tcaaagaaca aggttcaaaa 2182141 atcggcattc agcttgccca tgccggacgt aaagctgagc ttgaaggaga tatcttcgct 2182201 ccatcggcga ttgcgtttga cgaacaatca gcaacacctg tagaaatgtc agcagaaaaa 2182261 gtaaaagaaa cggtccagga gttcaagcaa gcggctgccc gcgcaaaaga agccggcttt 2182321 gatgtgattg aaattcatgc ggcgcacgga tatttaattc atgaattttt gtctccgctt 2182381 tccaaccatc gaacagatga atatggcggc tcacctgaaa accgctatcg tttcttgaga 2182441 gagatcattg atgaagtcaa acaagtatgg gacggtcctt tatttgtccg tgtatctgct 2182501 tctgactaca ctgataaagg cttagacatt gccgatcaca tcggttttgc aaaatggatg 2182561 aaggagcagg gtgttgactt aattgactgc agctcaggcg cccttgttca cgcagacatt 2182621 aacgtattcc ctggctatca ggtcagcttc gctgagaaaa tccgtgaaca ggcggacatg 2182681 gctactggtg ccgtcggcat gattacagac ggttcaatgg ctgaagaaat tctgcaaaac 2182741 ggacgtgccg acctcatctt tatcggcaga gagcttttgc gggatccatt ttttgcaaga 2182801 actgctgcga aacagctcaa tacagagatt ccggcccctg ttcaatacga aagaggctgg 2182861 taatgcccat aagagatatc ctgtagagga tatctctttt tttattttta gagaaacgat 2182921 cggctaaggt tctccgtctc cctagtagaa ccaattagag gagatgactc caatgaaatc 2182981 agcttggatg gaaaagacat atacaattga cggatgtgcg tttcatacac agcaccggaa 2183041 aggatcaagc ggtgtaacga ttgtctttga ggccggctat ggtacttctt ctgagacgtg 2183101 gaaaccatta atggcggaca ttgatgatga atttggcatt ttcacatatg atcgggcagg 2183161 cataggaaaa agcgggcaaa gcagagctaa acgaacagct gatcaacaag tgaaagaatt 2183221 ggagagtttg cttaaagcag ctgatgtaaa acctccttat ttggctgttt cacactcata 2183281 cggagctgtc atcaccggtt tatgggcctg caaaaacaag catgatatta tcggcatggt 2183341 ccttcttgac ccagctttag gcgattgcgc cagctttacc tttatacccg aagaaatgca 2183401 caaatcacat acgagaaaga tgatgcttga gggcacacat gcagagtttt caaaaagtct 2183461 gcaggagctc aaaaagcggc aagtccactt aggaaacatg cctcttcttg tgttgtcatc 2183521 aggagaacgg actgagaaat tcgctgctga acaggagtgg caaaacttgc acagcagcat 2183581 attgtctcta tctaaccaaa gcggctggat tcaagctaaa aacagctccc acaacatcca 2183641 tcatgatgaa cctcatatcg ttcacttggc tatttatgac gtatggtgcg cagcgtgcca 2183701 gcaggccgct cctctttacc aggcagtcaa ttaacgtaaa aaaagaccgg gccgtaaggg 2183761 attcccggtc ttttatatta ttttgtttca cggtgaaggg tatatttctt taaacgcggt 2183821 gaatattttt tcagctccaa acggtctgga ttggtgcgtt tattttttgt tgtgatgtaa 2183881 tttcggtctc ccgtttcagt gcaaagctaa agtaacattt actctcataa ttaacatctc 2183941 cttataaaac gtaatgatta cgttttatta tacaacgtca tcacaaattg tcaaataaga 2184001 gctccgcctt cagcctcgcg ggacgtttac ctctaagaaa tcatatgccg ccacgctatt 2184061 ggggaaaacg tcaaccgctt ctttttgaag ctccaaagaa gcatctccct gatatcttgc 2184121 gctgatatgg gttaaaatga gctgcttcgc tcttgcttct ttcgctgtta cagccgcttg 2184181 ttccgttgta ctgtgataat aatcataagc aagtttacgg tcttccttag caaaggttgc 2184241 ttcatgaaca agcacatcac aatccctcgc aagctctttt agtttgtcac ttactctcgt 2184301 atcaccggag aacacaacag atcttccctt tttaggaggc tccagaaaat cattcccatt 2184361 gatgattcgt ccgtcttcaa gcgttaccgt ttcgcctttt ttgattttct gatatacagg 2184421 tccgggcggg atgttcattt cttttaatac gtcagccttc aaggaacccg gtacgtcttt 2184481 ttcctgcaca cggtacccga aggcttccac tccatgaata acagataccg ctgtgacaat 2184541 aaactgatcg tcctcaaaca cgattccttc ttcaatttcc tggatcgcaa gcggatatgt 2184601 caaatgggtt ttcgtgacgg caaggcttgt ttcaataaac gccttgatcc ctttaggtcc 2184661 gtacactgtc agctcgtcct ctccgccttg aaaggaacgg ctccccagaa gccccggaag 2184721 tccgtataca tgatcgccgt gcatgtgtgt aataaagatt ttctctattt tacgaggttt 2184781 aatcgttgta tgtaaaattt gatgctgtgt ggcttccccg cagtcaaaaa gccataccga 2184841 acgcctttct tcaagcaatt ttaatgccac cgacgttaca tttctcgcct tggcggggat 2184901 gccggctccc gtccctaaaa aaagtaattc cacgtttcct tcctcctact agaaccagat 2184961 acctacaaga atacaggatc aagcggaaaa tgtgaatctt gcctctgaaa agaacaatcc 2185021 tttcgtgcta gaaacatttt ttcagcattc tgcttaaaaa agggcttaaa tgtttgcttt 2185081 cgttgaattt tagatttaaa atgaaggaaa tatacggggt gtactaaaat aaagcttcga 2185141 ataaagtgag gtacttttag tgaaaacaaa ccaacaacca aaagcagtaa ttgtcatatt 2185201 cggtgcaact ggagatttag caaaacgaaa attgtatccg tctattcacc gtttatatca 2185261 aaacggacaa atcggagaag agtttgcagt ggtaggagtt ggaagaagac cttggtctaa 2185321 tgaggatctt cgccaaactg ttaaaacatc catttcctca tctgcagata agcatataga 2185381 tgatttcacg tctcattttt actatcaccc gtttgacgtg acaaaccctg gttcttatca 2185441 agagctaaac gtattgctta accagctgga agatacatat caaattccta acaacagaat 2185501 gttctacttg gcaatggctc ctgaattctt cggaacgatt gcaaaaacat taaaatcaga 2185561 gggtgtaaca gctacaaccg gctggtcccg ccttgtcatc gaaaaaccgt tcggccatga 2185621 tctgccaagc gcacaggcat tgaataaaga aatccgcgaa gcatttacgg aagatcaaat 2185681 ttacagaatc gaccattatc taggcaaaca aatggttcag aacattgaag tgattcgatt 2185741 tgccaatgcg attttcgaac cgctttggac aaaccgctac atttcaaaca ttcaaatcac 2185801 atctagcgaa tcactaggcg ttgaagaccg cgcaagatat tacgaaaaat caggcgccct 2185861 tcgcgacatg gtgcaaaacc atattatgca gatggttgcc cttcttgcaa tggagccgcc 2185921 tatcaaattg aacacagaag aaatccgcag cgagaaagtg aaggtgctga gagcactgcg 2185981 tcctattgca aaagacgaag tggatgaata ctttgtgcgc ggacaatatc atgctggtga 2186041 aattgacggt gtaccggttc ctgcttatac agatgaagat aatgtcgctc ctgactccaa 2186101 tacagaaacc tttgttgccg gcaagctctt gatcgacaac ttcagatggg ctggtgttcc 2186161 attctacatc agaaccggaa aacgaatgaa agaaaagtcc acaaaaattg tcgttcaatt 2186221 taaggacatt ccgatgaacc tgtactacgg taatgaaaac aacatgaatc cgaacttgct 2186281 tgtcattcat attcagcctg acgaaggcat tacgctttac ttaaatgcta aaaagcttgg 2186341 cggagcagca cacgcacagc caatcaaact cgattattgc agcaattgca atgacgagtt 2186401 gaacacccct gaagcatatg aaaaactaat tcacgactgt cttcttggcg atgcaacaaa 2186461 ctttgcacac tgggatgaag ttgccctttc ttggagcttt gtcgactcta tttctgaaac 2186521 atgggcagca aacaaaacct tatctcctaa ctacgaatca ggctcaatgg gaccgaaaga 2186581 atctgatgat cttttggtga aagacggctt acactggtgg aacatataat aagaagaaaa 2186641 aagccgaaaa tgtttacaag cattttcggc ttttttacgc tgaacaaagg tataacaatc 2186701 tccttaataa caaaaccccc aaagcttaag agcttcgggg gtttctattg attacttcat 2186761 ccattcagta tggaagatgc cttctttgtc agtacgctca taagtatgag cgccaaagta 2186821 gtcgcgctgt gcttggatta agtttgcagg cagtacggct gtgcggtagc tgtcatagta 2186881 ggctaatgcg cttgagaatg atggcaccgg cacaccttgg gcaactgcaa gtgaaatcac 2186941 ttggcgaagc gctccttgat agctttctac aatattcttg aaatagctgt caagaagcag 2187001 gttgtcaagc tcaggctcgc gatcgtaagc ttctttgatc ttctgaagga atgccgcgcg 2187061 aatgatgcaa ccaccgcgga agatcatagc gatttcacca tatttcagat cccagttgta 2187121 ttcttcagaa gcagctttca tttgggcaaa tccttgcgcg tatgaacaga ttttactcat 2187181 gaacaacgct tttctgaccg cttcaatcag ctcttcttta ttttctgtaa caggcttcac 2187241 ttctggtcct gaaagaagtc cgctcgcttt tacacgctct tccttcatag ctgagataaa 2187301 gcgtgcgaat acagattcag taataatcgg aagcggaacg cctaagtcaa gtgcgctttg 2187361 gcttgtccat tttcctgttc ctttttggcc tgctttatca agaatcacat caacaagcgg 2187421 tttgcctgtt tcttcgtctt tttttgtgaa gatgtcagcc gtaatctcaa tcaggtagct 2187481 atcaagctca cctttattcc attcagcgaa aacttcatga agctcatcag cagaaaggcc 2187541 cagcacctgt ttcagaatga aatatgattc agagatcagc tgcatatctc cgtattcaat 2187601 tccgttgtgc accattttta cgtaatggcc ggcgccgtcc ggaccgatat atgtcgtaca 2187661 aggttctccg tcaacttttg cagaaatggc ttcaagaatc ggttttacaa gctcatgtgc 2187721 ttctttttgt ccgccaggca tgatagaagg tcctttaagc gctccttctt ctccgccgga 2187781 aacgcctgtt ccgataaaat gaatgccgct ttcagcgagt tctttgttac ggcgctgtgt 2187841 atctttatag tatgtattac cgccgtcaat taaaatatca tccttctcta gatgaggaag 2187901 aagagattga attgtcgcat ctgttgcagt tcccgcttta accattaata agattttgcg 2187961 cggtgtttcc aaggattgga caaattcttc aatgctgtaa gtgccaacaa cattttttcc 2188021 ttttgcctcc tgtaaaaact cctcagtttt actgcttgat ctgttgtaaa cagaaacaga 2188081 aaatccccgg ctttcgatat ttaaagccag atttttaccc atgaccgcaa gtccgataac 2188141 gccgatttgt tgttttgaca tattctaacg tcccttctgc aaacgtttaa tcattttaaa 2188201 atttaaatta aaataaaatg atatttataa taaagaaatt accatacatt cacccttttt 2188261 ttcaagcgat tcagcttttc ttttcatctt gaaaaaaatc tttattaaag cttgttccct 2188321 ttgttttgct ctcctctttt tttaacgttg ccccttttct gatcagtttg gtaccgtact 2188381 ttttattcag cttttccatc atctgctgaa tgggctcatc cttcgcatct tcattaaagc 2188441 tgaacaaatc gagctgttta taggcctgct ctttttctac taaatccgtt ccggtaatgc 2188501 caagcagcct gacaggattt ttattccaat gtttaaaaaa gaggtgctcc gcttctttca 2188561 aaatgtcatt tttttgatca atcgggtttc tcagcgtagt gcttcttgtg atggttctcc 2188621 aatccgcata tctaatcata ataaaaagct tcgaagccat gacttccttg cgctgtaaac 2188681 ggtcactcac agaagcggca agctttctaa aaacgcctaa cagctcttct tcatcactgg 2188741 aatcatggga aagtgtcgat gagttgccga cgcttttaaa ttcgtaaatg cgctccgggt 2188801 caaccggcgc atggtgaatg ccatttgctt tatttttaag gcgcggaccg ttgatgccaa 2188861 gcaggcgctt cagcgagtgt tcatcagctg cagctagctc tccgattgta tggatgccga 2188921 gtcccttcag tttttccgct gtctttttgc cgactccgtg catctctcca acaggaagcg 2188981 gccacaggat atcgggcact tgcctctttc ttaagatcgt aattccaagc ggttttttca 2189041 tatcagacgc catcttagcg agaaatttat tcggtgcaat ccctatgctt gacgggagca 2189101 gcagctcttt ttgcagcctg ctttggattt cttttgccgt ctctagagcg cggctgctgt 2189161 atggtgtatc ggtcatgtcc atatagcctt cgtcgatgga gacaggctcc actaggtcag 2189221 tatattcacg aagaatggta aacatcgctc gtgaagagtt tctatagcgg tcaaagttcg 2189281 gcggaagaac gatgagctca ggacaatggc gcttcgcttg ccaaaccggc atcgttgttt 2189341 tgacgccgcg cgctcttgct tcgtagctgc atgttaccac aatgcccttt cgctccttta 2189401 cgtttccggc aactgcgacc ggctttcccc ggagagccgg atcatatgcc atttcaaccg 2189461 acgcataaaa gctattcata tcaatatgga aaataattcg gctctttccc ggcataaaca 2189521 aatctccttt tcggtcatta gacaacagct tgtacatata gtaaaatgaa gctattgaat 2189581 ggatgtgatg acaatgtttg tggaatcgat aaatgacgtt ttattcttag tcgatttttt 2189641 cacaattatt cttcctgctc taacggcaat cgggattgca ttcctcttac gggagtgccg 2189701 tgcgggcgag caatggaaat caaaacgaac agatgaacat cagacggtct ttcacattaa 2189761 ccgaacagac tttcttatta ttatatatca tcgcattaca acttggatac gtaaagtctt 2189821 ccgcatgaat tcgcctgtga acgatgagga agacgccggt tctcttcttt tataaaccgc 2189881 atttataaaa aggaggagaa caaaattgtt aaaaacatat caaaaacttt tggctatggg 2189941 tatctttttg atcgtattat gctcgggcaa tgctgcattt gcagcgacta atcaggtggg 2190001 aggcctcagc aacgtaggtt ttttccacga ttatttaatc gaaccgtttt ccgctctgct 2190061 taagggtgtt gccgggctgt ttcacggaga atacggactc tctattatcc tcgtaaccat 2190121 tattgtgcgt atagttgtat tgcctttgtt tgtcaatcag ttcaaaaaac agcgcatctt 2190181 ccaagagaaa atggccgtta ttaaacctca ggttgacagt atccaggtta agttgaaaaa 2190241 gacgaaggac ccggaaaagc aaaaagagct gcaaatggaa atgatgaagc tgtatcagga 2190301 gcataatatc aacccgcttg cgatgggctg tcttccaatg ctgattcagt ctccgattat 2190361 gattgggctt tattacgcga ttcgctcaac acctgaaatt gcgtcacact cgtttctatg 2190421 gttcagttta gggcaatctg atattctcat gtcccttagt gcagggatta tgtattttgt 2190481 ccaagcctat atcgctcaaa aactgagcgc gaaatattcc gctgtcccgc aaaaccctgc 2190541 agcgcagcaa tccgcaaaat tgatggtgtt catcttccct gtgatgatga cgattttctc 2190601 gcttaatgtg ccggcagccc ttccgctgta ctggtttaca agcggactgt ttttgacagt 2190661 gcaaaacatc gtccttcaga tgacgcatca taaaagtaaa aaaacagccg ctcttactga 2190721 gtcggtgaaa taaaaaagca accccgtgca aaaagccggg gttgtttttt gttacttgca 2190781 aagtaccgcg ccaaacagtc ttgtttatca tggctgaagc agaaatggcc atcctaaaaa 2190841 atagccgtat cgtttaaaaa gaaggaaatc gggaatacct ttactcacct ccaaccgaaa 2190901 ggagcctata cgttgacgga acgctttcag caaaaaaata tttctgtacc tgatggaatc 2190961 tggatcatga gacaaacctg gaatgatgtc ttatttgctc actggcctgt tgatgtttct 2191021 atccttcgcg ctttggtacc gtccgtttta gaattagata catataacgg gcaagcttgg 2191081 atcagcatgc ttccctttat gctcacgaac ctgagggcgc gttatctccc tgtcattccc 2191141 ggtgcgcgtg catttcctga gcttaacctc cgcacctatg tcacgtataa aggcaagccc 2191201 ggcatttatt tttttagctt agatgccgat catcgtctgg cggtccttgg cgctcgcaca 2191261 ttctttcatc tgccttattt ttacgcggat atgaagtccg aaaaaaacgg tgatgccatt 2191321 gactatgtca gcaagcggaa aaatgacaaa gaagcagcat tccacgccgc ataccggcca 2191381 atttcagcgc cttttacagc agaaaaggat tcgctcgatt actggctgac agaacgatac 2191441 aggctctaca ccacttatcg caataagctc tattacgaag acatccatca tcatccgtgg 2191501 ctgctgcaaa acgccgaagc agaaatttca gtcaatacgg tgactgatgc tcacggtatt 2191561 acattgccgg agtcagaccc cttgcttcat tatgctaaaa aacaggatgt gttattttgg 2191621 ccgcttagga aatggagcta aaaaaacccg atgcgggaaa tcgcactcgg gttttctttt 2191681 tttattttgc cgcctcttca ataatggcaa caaccatttc tgccgtttta acgagctctt 2191741 cgatcggcat tttttcattt tttgtatgga tttgctcata accgacagca agattgaccg 2191801 tcgggatgcc atgaccagcg attacgttcg cgtcgcttcc gccgccgctc gtttgcagct 2191861 cgcttggacg tccgatttta gcagccgctt ttttcgcgat ttcaacaact tggtcgccgt 2191921 cttgatattt aaagcccgga tacataacct caatttcgac ttctgcgcgt ccgcccatat 2191981 cagcagctgc ctcttcaaaa gcagctttca ttttttgaac ctgagcttcc attttctcag 2192041 gaactaaaga gcgcgcttca gcaagaatat gaacttcgtc gcacacaatg tttgtttgtg 2192101 tgccgccttc aaaccggccg atattagctg ttgtttcttc atcgatacgg cccaatggca 2192161 tttttgagat ggctttgcta gcgattgtaa tcgctgaaat gcctttttca ggttcaaccc 2192221 cggcgtgagc ggttttcccg aaaattgccg ctcttacctt cgcctgtgtc ggcgcggcca 2192281 caatgatatt tccgactttt ccgtctgaat caagagcata gccgtaggat gcagtgatca 2192341 tagaacggtc aagcgccttc gctccgatca gacccgattc ttcccctact gtgatgatga 2192401 attcaatcgt gccgtgttca atattttctt ctttcagcac cttaatcgcc tcaaacattg 2192461 cagccaatcc cgctttatca tcagcaccta aaatcgtcgt gccgtcagtt ttgacgtaac 2192521 cgttctctac aactggtttt acgccgtttc cgggtacaac tgtgtccata tgagatgtaa 2192581 aatagatcgt atctgtttgt tttgtccctt ttagcgtgca aatcaggtta ccggctccgt 2192641 ggcccgtgat atccattgta tcgtcttctt taacgtccac acctaaatca gaaaattttc 2192701 gtttcagcac tttgcagatt tcagcttcgt gctttgtttc tgagtcaatt tggacaagct 2192761 ctaaaaattc ttccagcagg cgtttttcat tcaccatttg taagtccctc catattaaag 2192821 cggtatgtta ccgtgctttt ttttcggtct ctcttctgtc ttatgtgtaa gcatatgaaa 2192881 agcttgaatc agtcttcccc ttgattcttc cggcaaaatg atgtcatcga ccattccaca 2192941 agcggccgct ttgtatgggc cggcgttttg ctttttgtat tcagcagttt tttcgcgttt 2193001 cgtcttttgc gggtcagctg aagctttgat ttccttttca tacaaaatcg atgccgcacc 2193061 ttctggaccc atcactgcga tttcagcatt cggccatgca aacacaaggt ccgctccgat 2193121 cgctttgctg ttcatggcca cataggcgcc gccgtacgct tttctaatga tgagtgtgac 2193181 ttttgggaca gtcgcttcag cataagcaaa caataatttt gctccatgcc tgatgattcc 2193241 gttgtgctct tgctgaatac ccggcagaaa ccccgggaca tcttcgacag tcaacagcgg 2193301 gatatcaaat gcgtcacaaa aacggatgaa ccttgctgct ttatcagcag cgtcaatcgt 2193361 caggcttccc gccagatgct tcggctggct cgccacgatg ccgattgctt tttcacccag 2193421 ccttgcaaac ccaatgacaa tgttcttcgc aaaaaatggc tgaatctcaa aaaaagactg 2193481 cgggtcagcc agctccctaa tcaccttccg aacatcataa ggctttgtcg tatcagcagg 2193541 gacaagacgg tttaataacg gtctggacgc ctctttctct ggcttcggct ctgttgtccg 2193601 gccattcagc ggcaaataag acagtagttt tctcacccct gtcagaacct ccttctccgt 2193661 atgcccggaa aagtgggcgt ttccgctgac ggcattatgt atccccgctc cgcctaagct 2193721 ctccgcatca acctgttccc ctgtcacttt ttcaatcacc ttcgggccgg taataaacat 2193781 ccggccagtc tgttcagcca taaatataaa atctgtgagt gccggagaat atacagcgcc 2193841 tccagcgcac ggccctaaaa taaccgatat ttgcggaatg actccggaat ataagacgtt 2193901 tcggtaaaat atgtgaccgt atccatctaa tgataacaca ccctcttgaa ttctcgcacc 2193961 acctgagtca ttcagcccga taatcggcgc cttatttttt gctgccagat ccatcaaagc 2194021 gcagattttc ctggcatggg tttcgccaag cgcccctccg tacactgtga agtcttgcgc 2194081 aaatacataa actgagcgac cgtcaattgt gccgtaccct gtcacgaccc catcccctaa 2194141 catgcgctgt tctcttgtta acacttgact ttccatgaag gggtgtaatt cgataaagct 2194201 gtcctgatct agaagaaata tgatcctttc ccgagcagtg agcttgccct tttgccgctg 2194261 ctgagccagc ttttcccgtc ctccgccttc ttctgcctgc ttgcgtttcg tgtaaaaatg 2194321 atccatgtgc tcattcatgc tcattgtgtt ggtctccttt cggttcacaa agctctacaa 2194381 gaacaccgtt tgtttcccga ggggaaataa acgcgatctt tttcccgttc gctccctgtc 2194441 ttggaaacct gtcaatcaat tgaacatgct gatcagacaa tgcttgaagc tgttcagata 2194501 ggcagttgca caaaaacgca atatgatgca gtccctgccc tttcttctcc aaaaataaat 2194561 ggacggggct gtcagctgtc aacggctcta tcagctcaag tttgacgcta ccagcttgaa 2194621 aaaaagcaac attcaccttt tgctcttcaa ccgtttcttg atgaagaaat gcaagcccca 2194681 atacattttc ataaaagctt cttgcatctt ttatcgaaaa aacggctatc ccgatatggt 2194741 caagcctgtt cattttcatc cctgctttcg ctaatagata tcgcttgtcc gcccattcaa 2194801 aacacgctaa aatatagaca gattgtttaa ggagtgaaaa tcatgtctca aaaactgatg 2194861 aaaagcgttt tgatcgtgat tttgggagtt tttattcttt caactgtact ctcaggaatc 2194921 gtcatgtttc tataacgata aaaaagcagg cgccttattc aatgggaata tcctgctttt 2194981 ttatcagagc tttatgctcg atggcaatct cctcaaaaga gcggttgtcg tccgtgatca 2195041 gcactctcgt tcctactggt atcgtttgaa acaaatgaac aacctcatcg ttatgcatac 2195101 gtatacagcc gttagacaca aattttccta ctgattcctc tcggtttgtc ccatgaattc 2195161 cataaatccg cccgtccgtt cctttcgcgt caaatccgat ccatcttgcc ccaagcgggt 2195221 tatcaggaga tcccccttca atatttttct ttctgtagta aggattttcc gcttttaccg 2195281 ttaccgaaaa ctctccttca ggcgtcaaat catctgtttt tccagtcgcc acactataca 2195341 cgccttctac tttgttgtcg aggataacag caagttcatt tgttcgcttg ttgacaataa 2195401 catacggatc acccggcagc ggattttcgc cgagcggcca aatcggtgaa atcatcatga 2195461 aaatcgaaca taagaaaaaa cgcataagct cctccttttt cattaggttg accaatgaag 2195521 gaagagctca tgcgaatcat ccgagtgatt tttgcgcttt tattccttta aaataacttt 2195581 taatcactaa atattgttcc atttcgccga gaagatggaa gagagcggcc ctcgcttcaa 2195641 attcctctct agtcgcagga agcggcatct cctcaaattc ttttctcatg tcagcaagtc 2195701 ttttcagaaa tttgtatgct gtattcccag ggtgtatcgc ctcccgcaaa tcatgaataa 2195761 attcagcgat catttttccc tgatctaccg tgatggagat cgatgtcact ttagggagaa 2195821 ggcgttcgat aatttcaaat tgcttttctc tcattttaaa ataatgataa tgcagatttt 2195881 cataacgcaa aatgtggttt tgcacatctc gatatgccag gtttttagcc tccgtaatga 2195941 gctggtgcgt ttccggaatt tcttttcctg accaatcttg ctcaccagtt aacaaatacc 2196001 gttcgatttc tgcaaaaatg acagcaaagt tatcctctat ctttttgcgg taggcaatca 2196061 gtttccggtc aagactaggc atatacaagt tcatcaatag agcgacgccg atgccaaccg 2196121 taatcagctg aacttcattc cagatgaaag taggcgtaat gccgccggac atgtataaat 2196181 gaaggataat aacagaactg gtgacgatac cctcgttaat ttttaacaga accgttatcg 2196241 gaatgaatat caaaagaagc gctccgatca caaacgggtg gtagccaata agctcgaaaa 2196301 agagataaga aaaagcaatt gccagacagc atgccgaaaa gcgggcccat gaggcctgaa 2196361 gcgaccgttt ttgtgtgatt tgtatgcaca aaatggtgat gattcctgct gatgcgaagt 2196421 tttgcaaatg caataactgg cttatataaa tagccaaagc tgttccaagc gcggtcttta 2196481 ttgtgcggta accaatttta aacatgtcgg actccatttc tatttgtttc ttcaataaaa 2196541 aagaagaggc ggccagcctt cttctttttt atattctata atattttctc taaaaagtcc 2196601 tgcgctcttt tggattttgg cgacataaaa aattccttcg gattgccgtc ttcgacaatc 2196661 attccttggt ccataaacag cacacggtct gccacttctt ttgcgaagcc catttcatgt 2196721 gtgacaatca ccatggtcat gccggtttcg accagctctt tcatcacctg tagcacttct 2196781 ttgaccatct ctggatcaag ggcggaggtc ggctcgtcaa acagcatgat gtccggattc 2196841 atcgcaagag ccctggcaat cgcgacacgc tgtttttgtc cgccagacaa acggtttgga 2196901 tagtcatttc gcttttcaaa caaaccgact ttgcggagca ggtcctcagc tttctcctgt 2196961 gcagcctgtt ttgattcttt ttttacattg acaggcgcgt acatgatgtt ttcgagaacc 2197021 gttttgtgcg gaaagagatg aaaatgctga aaaaccatcc cgatgttttc ccggaccttt 2197081 aatgtgttgg ttttcggctt cgtaatctct gtgtctttta ttgtaatggt tccgccgtta 2197141 ggcttttcca acaggtttaa acagcgtaag aacgttgatt tgcctgagcc tgaaggaccg 2197201 atcacggcaa caacctcacc ctcagcgatt gttgttgaaa tgttttttaa tacttcgtgt 2197261 ttcccaaatg attttgacag cttttcaacc ttaatcattg gatttcagct tcctttctac 2197321 agccttgccg ataaacgtta aaatcaggac aagcacataa taaatcaatc ccgcgataat 2197381 gagcggctca aggtaattgt aagtggcggc gccagcttga tatgcgcgtc tcatgacatc 2197441 accaagcccg atgacggtga cgatcgccga ttcttttgtt aacgtaatta attcattcac 2197501 aattgcaggt gatatatttt tgaaggcctg cggcagcagc agatccttca tcatttttcc 2197561 atacgggaca ccgagtgcaa cagcagcttc tttttgccct ttatcaatgg cattgattcc 2197621 ggctctgata atttccgata cataagcggc ggaattcaaa gacaatgcga caaccgcagc 2197681 ccaaaactgg tcaatttgaa atccgagcag ctgaggaagg ccaaaataga caatcataag 2197741 ctgcagcact aaaggcgtgc ctcggaacac tgatgtataa aaatcagcga tccagataaa 2197801 cgggcggaat gtgctgatct tgcataagct tagcacaata ccgagtataa gtccgataat 2197861 agcagataca acaacaattt ttaatgtaat tgccaagcct tctaatataa aaggaatttg 2197921 ggggatcgtt gctgaaaaat ccaaattcat agcctttgtc tccttttctt acaggaaaaa 2197981 agtttcctat tcaataaaaa ggctcaacga aaaagttgag ccgctttttt ttacttctcg 2198041 ccagtgaacc attttttctt caatttctca agctctccgt tatcttccat ttccttgagc 2198101 gctttattga atttgtctgt cagttcactg tcctttctga aagcaattgc tgaaccggct 2198161 tcttccgctt tcgcatcagg aatcacaaag ccttgcaggt catcatttga tttgaaatac 2198221 ccttctgcaa caatgtcttc aataatcgcg gcatcgaagc ggtcagattt gatttcctgc 2198281 accaaatcag aaattctgtt gcggtcttct gttttaaaac catattccgg agaaagctct 2198341 ttccccttct cttcctgaat agagccaagc tgaacgccaa ctgtttttcc tttcaggtct 2198401 ttcaaagatt gaatgccgct gtcttttttg ctgacaatca tatggttcgc tgtgtaatac 2198461 acatcggaaa aatcaacttg ttttttacgc tcaggcgttg gtgtcattcc tgacagaacg 2198521 agatccacct gttttgattt aagcgctgta attaagctgt tgaagtccat atcctgcact 2198581 tcaatttcat agcctgcctt ctttgccaga gcttttgcca gctctacatc aaagccgaca 2198641 atattatctc cttctttata ttcaaacggt ttgtaatccg ccgaagtacc cataattaat 2198701 tttttctttc cgctttctga acctgaattg cttgagccgc acgcagttaa tgcaaaggtg 2198761 atgcaagcag ccacaagtaa taagagccat tttttcatga tccatttccc ccgtattcat 2198821 tacttttggt gtatttgaat atttattcgt taatttgtat tttaaacagt ttctcatttt 2198881 tatgcaatac tatttttaaa aattatcttt aggcttatct ttccagtgat ctcttctgat 2198941 attactagat aaaaattaaa tcgctgtaca atccgattga ataatccctt aatatttatt 2199001 catatatcct tggaaattta tgcacaaaaa aacccgggct gctttgagca tccgggttgt 2199061 tcgtcttata cttcttcaca atattcttca aaggcttcct gcagctttgc cactacagcc 2199121 atcggctcat ggccttcaat ttcatgacgc tctaccattt tcatgatctt tccgtctttc 2199181 aaaatcgcaa aggacggaga agatggtgga taaccttcaa aatagtcacg cgcacgcgct 2199241 gtcgcttctt tatcctgtcc ggcaaaaacg gtgacgagct gatcaggtct tttatcatag 2199301 tgaacggaat ggtaggctgc cggtcttgca attcctccgg cgcatccgca aacagagttt 2199361 accatgacga gcgtcgttcc ttttttcgta agtgcctcat ccacctcttc ggctgtttta 2199421 agctcggtgt atccggcagc tgttatttct tgtctcgctt ggcggacaat atcattcata 2199481 aataaattaa agtccatgtt caatgaagac ctctcctttt tcatcatctg ttcttatgat 2199541 agcaaggaaa cgtccatatc ggcaaatgac tttgcttcgc cgtgcacttt ttttgctctt 2199601 cgtttactgc ttacagaaaa aggggattat ataaccagaa gtaaaataaa ggagcagttg 2199661 tatatgagcc accggaaagc gttactgatt cataacggaa atgccggcaa caaaaatata 2199721 gaaaaagcac ttggtgctgt ggtgccggtt ttatctcacc atttagatga ggtgattatt 2199781 aaacagacaa agaaaaagga tgatgcgtat catttttgcc gatccattga tgattctgtc 2199841 gacaccgtct tcattctcgg cggcgacggc acgatccatc aatgcataaa tgctatcagc 2199901 gctctagaaa gaaaacccgc tgtcggaatt ttgcccggcg gcacgtgcaa cgacttttca 2199961 agagtgcttg gcatccctca aaatcttgca aaggccgcgg aagcacttat ggcgggaaaa 2200021 aaaaccagcg tagacgtatg tcagatgaat gaccgttatt ttttgaattt ctgggggatc 2200081 ggcttaattg cagaaacgtc gaatcaaatc aacgaaacgg aaaaagcatt attgggaaaa 2200141 atcagctatt ttacaagtgc cttgcgaacc gtctcatctg ctgcatcgtt tccgatgaca 2200201 ttaaaaattg atggagaaga aattaaagaa gaagccgtta tgctgcttgt gatgaatggc 2200261 caatacattg gaacgaatcg aattcctctg cccgatgcca gtattgaaga cggcttactt 2200321 gatgttctca tatgccgcaa taccaacctc accgcgctgc gggagctgat gagcatggaa 2200381 caaggctcaa ttgatcgttt tactggagag ttgtcctatg tccaggcttc ccgtatcgag 2200441 attgaaacag acactgccaa aaaggcggat atggatggag aagtttatac acatacaccc 2200501 gcagtcattc aggtcctgcc acagcatatc gacatgcttg ttcccgcaaa tgaataactg 2200561 tcataaggct ttagaaagat tttgcaaatc cgttgactct cccctaggag gaggtcttac 2200621 agtataaggg atacacactt gaaaaagggg aagtcatatg gagaagaaaa atattacctt 2200681 aactatatta ttaaccaatt tatttattgc ttttttgggg atcgggcttg tgattccagt 2200741 aacgccgacc attatgaatg aattgcattt atcggggacc gcggtcggct atatggttgc 2200801 ctgcttcgct attacacagc tcattgtctc accaatagcc ggacgatggg ttgatcgctt 2200861 cgggcgcaag atcatgatcg taatcggcct gttgttcttt agtgtgtcgg agtttttgtt 2200921 cggcattgga aaaacagttg agatgttatt tatctcccgt atgctgggcg gtatcagcgc 2200981 agccttcatt atgcccgggg tcacggcttt tattgcagat atcacgacca ttaaaacacg 2201041 gccaaaagcg ctcggttata tgtcagccgc tatttcaaca ggatttatta tcggccccgg 2201101 catcggggga tttttagcag aagtccattc ccggctgcct tttttctttg cggcagcttt 2201161 tgcactgtta gcagccattt tatcaatcct cacgctgcgc gagccggaac gaaaccctga 2201221 aaatcaggaa ataaaaggac agaagacagg ctttaaacga atttttgccc ccatgtattt 2201281 catagctttt ctcattatct taatttcgtc ttttggttta gcatcatttg aatctttatt 2201341 tgcattattc gtggatcata aattcggatt tacggccagc gacattgcca ttatgattac 2201401 aggaggagcg attgttggcg ccattacgca agtcgtctta ttcgaccgct tcacaagatg 2201461 gtttggcgaa attcatttaa ttcggtacag cttaattctc tcgacgagtc tggtattctt 2201521 gctgacaacg gtacattcat atgttgcgat tctgctggtg acagtcaccg tatttgtcgg 2201581 atttgatctc atgcggcctg cggtaacgac ttacctgtca aagattgcgg gaaatgaaca 2201641 ggggtttgcc ggcggtatga attcaatgtt tacaagtatc ggcaatgtat tcgggcctat 2201701 tatcggcgga atgctgttcg atatagatgt aaactatcct ttctactttg caacggtcac 2201761 cttagccata gggattgcac tgaccattgc ttggaaagcg cctgcacatc ttaaagccag 2201821 cacgtgataa gaagcgcatt ctttgtgtac tgcaaagaat gcgcttcttc tttatactga 2201881 tgatagaagg agtgatggca tgaaggaatc gtattactca attggggaag tatcaaaact 2201941 ggcaaacgtg tcgataaaag cgctccgtta ttacgataaa attgatttat ttaaaccagc 2202001 ctacgtcgac ccggatacca gctaccgcta ttatacagat tctcagctca ttcatctgga 2202061 tttgatcaaa tcattgaaat atatcggcac acctttagaa gagatgaaaa aagcacagga 2202121 cttagagatg gaagaactgt ttgcttttta tacagagcag gagaggcaaa tcagggagaa 2202181 attagacttt ttatcagccc tggagcaaac catttcattg gtgaaaaagc ggatgaaacg 2202241 gcagatggaa tatcccgcgc tcggtgaggt gtttgtttta gatgaagaag aaatacggat 2202301 cattcagaca gaggcagaag gaatcgggcc tgaaaacgtg ctcaacgcct cctacagcaa 2202361 attaaaaaaa tttatcgagt cagcagatgg atttacgaac aatagctacg gcgctacttt 2202421 ctcttttcag ccctacacca gcattgatga aatgacttac cgtcatattt tcacacctgt 2202481 attgacgaat aaacagattt catcaattac gccggatatg gaaatcacaa cgatccctaa 2202541 agggaggtat gcgtgtatcg cgtataattt ttcgcctgaa cattattttc tcaacttaca 2202601 gaagcttatc aaatatatcg cggaccgcca attaacagtt gtcagtgatg tatacgagtt 2202661 aatcataccg attcattact ccccgaaaaa acaagaagaa tatcgagtcg aaatgaaaat 2202721 acggatcgct gaataataaa gcatagaaaa agagcatttt ttgaaacaaa acttcaaaaa 2202781 atgctctttt tgcttattta gtaaacagat gtcttctcgt caatcgattc taaaatttgt 2202841 ttcactcgtc cgaggaatcg tccgcacacg agaccgtcaa gcactctgtg atctaatgac 2202901 aggcacagat taaccatgtc tctgacagca atcatgccat tgtccatgac aaccgggcgt 2202961 ttgacgatgg attctacttg aagaatcgca gcctgagggt agttgataat gcccatcgac 2203021 tgaacagacc cgaacgaacc tgtgttgttg acggtaaacg tgcctccctg catgtcatct 2203081 gcagtgagtt ttccgtctct tactttttta gctaggccgg taatgtcttt cgcaatgcct 2203141 ttaattgttt tttcatcagc gtttttaatc accggaacaa ataaagaatc ctctgtggca 2203201 actgcaattg aaatattgat atcctttttc tgaataattt tgtcccccgc ccacatgcta 2203261 ttcatttgcg ggaattcttt taacgcctga gcgaccgctt ttacaaaaaa ggcgaagaac 2203321 gttaaattaa agccttctgt cttcttaaaa gaatctttta tactgttgcg atatgcaacc 2203381 atatttgtga cgtcgacttc catcatcgtc caagcatgcg gaatttctgt tttgcttcgc 2203441 ttcatattgg aagcaattgc ttttcttaca cctgtgacag ggatttcttt atcaccggct 2203501 gcagacgcag gatatgacgt ctcttctttt ggctcaggtt ttgatgcaga cttcggtgca 2203561 ggagctgctg ttttcagctc ctcaggattc tgttcttgca cgccgcctgt ttcaattaag 2203621 cgctgaatat cttttcgtgt gatgcgcccg ccggcaccag ttcctgtcac ttgatcgagg 2203681 tcaatgccgt gctctccggc caaacggaga acagctggcg agtagcgctt tttattgggc 2203741 tgatcggctg ctccagcact ttttgcaaca gggttctcag cggcttctga tgctgctggc 2203801 tgttcttgtt tttgttcagc cggattcgcg ccttctgttt caattttgca aatcatttct 2203861 ccgacttgca gggtttggcc ttcttctccc acaagctctg ttatcgtacc agtaaaagaa 2203921 gacggaacct ctgcatttac cttatctgtc atgacttccg cgatcggatc gtatttgttc 2203981 actttatcac cgggggcgac aagccatttg ctgatcgtcc cctctgttac gctttctcca 2204041 agctgcggca tcgtcatttg ttcaattgcc atgattgtat cctcccttac gtctttaaaa 2204101 ctccgctaat tctctcatcg ccgcttccac tttatcaggg ttgaccataa agtatttttc 2204161 cattgtcggc gcataaggca tagccggaat atcaggacct gcaagccgtt tgatcggcgc 2204221 gtctaagtcg aacagacaat gctcggatat aattgcggct acttcgctca tgatgctgcc 2204281 ttcttttgta tcttctgtga ccaaaagaac ctttccagtt ttggacgcag cttcgatgat 2204341 ggcttcttta tcaagcgggt aaactgttct taaatccacc acatgcgctg aaatgccatc 2204401 tttttcgaga cgttctgcag cttgtaaggc gaagtggaca cacaggccgt atgtgatcac 2204461 tgtgatgtcg tcgccttccc tttttacgtc cgccttgccg attggcagga cataatcatc 2204521 agccggaacc tcgcccttta tcagacggta tgcccgcttg tgctcaaaaa acagcacggg 2204581 gtcttcgtca cgaactgcgg cttttaagag ccctttcgcg tcatatggtg ttgatggcat 2204641 gacaattttc agtccgggct ggttggcgaa aattgcttcg actgattgag aatgatacag 2204701 ggctccgtgc acgcctccgc cgtatggcgc tctgacgaca atcggacagc tccagtcatt 2204761 gttgctgcgg tagcggattt tagccgcttc agaaataatt tggttgactg ccggcataat 2204821 gaaatcagca aactgcattt cagcaatcgg tctcattccg tacattgccg ctccgatacc 2204881 gactcctgcg attgcagatt cagcaagcgg cgtatccata acgcgctctt ccccaaattg 2204941 ttcatagagt cccgctgtcg ctttaaacac accgcctttt cttcctacat cttccccaag 2205001 gacgaaaacg cgagaatctc gttccatttc ttctttcatc gccaaattga ttgcatcaat 2205061 atatgacatt actgacattt gttcttcctc cctacttcgc ataaacataa tcaagcgctg 2205121 actcaggagc tgcatatggg gcgttctccg cttcatccgt cgcttcattt acgattgcca 2205181 taatttcatc cagcatggtt tgttctatct catcggacag caggcctgtt tcctttaagt 2205241 aagcttgata agtaagcagg ggatcacttt ttttcgcttc ctctacttct tcacggcctc 2205301 tgtagctgct gtcatcgtca tcactggaat gtggtgtaag gcggtaagaa atcgtttcaa 2205361 ttaatgtcgg gccttctcct ctgcgtgccc tttcgcgtgc ttctttaacc gcttgataaa 2205421 cttccagcgg atcatttcca ttcacagtta cgccaggcat cccatagcct atggcacggt 2205481 cggaaatgtt ctcacatgcg acttgcttat cgtaaggcac tgagattgcg tatttgttgt 2205541 tttcacacat gaaaataacc ggcagcttat ggacagcggc aaagtttgcc ccttcatgga 2205601 aatcgccttg gtttgaagac ccttccccga atgtaacaaa ggctgcgata tcctttttct 2205661 ccatacgtcc cgcaagcgca ataccgactg cgtgcggcac ttgcgttgta accggagatg 2205721 atcccgtcac aatgcggttt ttcttttgtc cgaaatgtcc cggcatctgg cggcctcctg 2205781 agttcggatc tgctgctttt gcaaacccgg acatcattaa gtcctttgct gtcatgccaa 2205841 acgcgagcac gacacccatg tctctgtagt acggcaatac ataatccatt tcacggtcaa 2205901 gtgcgaaagc cgctcctacc tgtgctgctt cctgtccttg acaagagatt acaaatggaa 2205961 ttttgccaga acggtttaac agccacattc tttcatcgat ttttcttgct aacagcatgg 2206021 ttctatacat atcaacggct tcctgatcag tcagccctag tgcttgatgt cggtttgtac 2206081 tcattcaagc ccctccttta tgcttttaaa aatgaatggc tttgccatct gcggcaagcg 2206141 cagcttctcc aattgcttca gaaagcgttg gatgcgggtg aatcgtttgc ccgacctccc 2206201 acggtgttgc gtccagcact ttggcaagac ccgcttcaga aatcatgtcg gtgacatgcg 2206261 ggccaatcat atgaacgccg agaatatcat ctgtatctcg gtcagccacg attttgacaa 2206321 aaccgtcgct ttcaccgtat acaagcgctt ttccaatcgc cataaatggg aacttgccga 2206381 ttttgacatt atgcccgttc gcctttgctt cgtcttcggt taagccgaca ctggcagctt 2206441 cagggcttga gtaaatgcac ttcggcacaa gcgtcggatc aagcggatgc ggattgagac 2206501 ctgcaaaatg ctcaacagca ataattccct catgtgaagc aacgtgagct aactgcaggc 2206561 caccgattac gtctccgatt gcataaatat gagattcctt cgtttggcag ctttcattga 2206621 ctgaaatcat gccattttca gtaacaatat cggtgttctc taggccgatg ccttcgatat 2206681 ttgcctgtct gccgatggaa acaagcattt tctcagcaga ataggtaacg gtttctccgt 2206741 ctttttccgc ttgtatgctg atatcgtctg atgtttttgt cattgtgtca ggcagcactt 2206801 ttgcccctgt tatgaactgg atgccttttt tcttaagaag actttccatt tcttttgaaa 2206861 tctctagatc ttcagtcggc aatatgcgat ccgcgtattc aataaccgtt accttaacgc 2206921 caaaatcatg aagcatagac gcccattcga taccgataac ccctccgccg acaatgatga 2206981 ttgactgtgg cagctcctcc atttggagcg cctcatctga agtcagtaca gacttaccgt 2207041 ccacttcaag acccggaagc attctcggtc ttgatcctgt tgcaatgatc acttgtttcg 2207101 ggatcagcat gtcattttct tcgccatttc cccgctcaac agaaattgtt cccggcagcg 2207161 gagagaagat tgacggtcca aggatacgtc catatccggt gtacacgtca atttttcctt 2207221 ttttcattaa atgatttaca cccgctgcaa gcttatcaac aacggcttgc ttacgctgct 2207281 gcactttttc aaagttgagg gacacgccag ccgtttccac tccgaattga tcggcttcac 2207341 gagctgtccg gtatacctct gcgcttctaa gcagcgcttt actcgggata cagcctttat 2207401 gcagacatgt tcccccgagt ttttcctttt ccacaacggc tgtttttaag ccgagctgag 2207461 cggctctgat ggccgcaaca taaccgccgg taccgccgcc cagaatgact acgtcatact 2207521 cagttgccat ggtgactcac tcctgtctgt ctattcaata cgatattgtt tggattgctc 2207581 ttcgccctgc aatactctta gcgccccttg ggcaagagac tgcagttcat tttcacccgg 2207641 ataaactaaa acgtctgaaa tccaatctat gtatgatctg atagcagaaa caaagctttt 2207701 tccgtacgca aggcctcccg tcagcacaat cgcttcaact tcgcctttta acgccgcgct 2207761 ggctgccccg atttcctttg ctacctgata tgccatggca tcataaatga agcgggcttt 2207821 ttcatcgccc ccttgaatca tctgttccac ttttactgca tcatttgtac cgagatagcc 2207881 taaaagtccg ccggtgccaa caagcttttt catgatttct tcttttgtat attcccctga 2207941 aaaacataga tcaacaagat ctcccgcagg cactgttcct gctcgttcag gactgaatgg 2208001 tccctcgccg tgcaggccgt tattgacatc caccactcgc ccgcggtcat ggacgccaat 2208061 tgtaatacct ccgcccatat gggtaataat cattttcatg ttctcatatc gtttgccaag 2208121 ggaggctgcc gctttacgag cgacagcttt ttggtttaac gcatggaaaa tgcttttcct 2208181 ttcaatttca ggcatgcctg aaactttcgc aagcactgac atttcgtcta cgacaacagg 2208241 gtcgacgata tacgaaggga tattcaggcc gtcagcgatt tcccgcgcga taatgccgcc 2208301 gagattagaa gcatgctgac cggcgtagcc gcttttcaaa tcctcaatca tctcatcatt 2208361 cactacgtag gtcccgcctt caattggccg gagaaggccg cctcttgcgc agactgcatc 2208421 aaactttgaa atattgattc cctgttcatg aagcgtttcg agaatatggt ttttacgaaa 2208481 ttcatactga tcaataattc ggtcaaatcg ctgcagctct tctatgttgt gtctcaatgt 2208541 tttttcaaaa atgcttcttt cgttatgaaa aacaccgatt ttcgttgaag ttgagcctgg 2208601 attaattgtg agaatgcgtt tttcgtcatg tagcactttc ataacctcca gatcaatttc 2208661 ttaacgtctg cttaatacac tgtggccgtt ttgcaaaaac tggcttcttg agcggcgcat 2208721 gcgttcaatc cgttcctctg ctaagcggtc agccgctaaa tatgcaggaa tgccgtcacg 2208781 ctgagaaatc tcaagtacac gctcgatatt gccgtaaatg ccttcaactt ttttcaatgc 2208841 acgttctgca ttatagccgt aaagctcatc tgccacgttg atgacaccgc ccgcgttaat 2208901 cacgtaatcc ggtgcataaa cgatgcccat ttcgtgaatt tgatcaccat ggcgtgtctc 2208961 ttttaattgg ttgttagccg cacctgcgat cactttcgcc ttcagctgtt taatggtgtc 2209021 gtcgttaata gtcgcaccaa gggcacacgg cgcataaata tcgcagtctt gtgaataaat 2209081 gtcatcagga tctaccgcac gggcgccaaa atcttcaact gcacgctgta cagattgttt 2209141 gttgatatcc gtaacgatta agtttgctcc ttcttcatgc aggtggcggc aaaggttata 2209201 ggctacgttc ccaacaccct gtacagcaat ggtttttcct tcaagagagt cggttccgaa 2209261 agcagcttta gctgctgcct tcattcctct gtacaccccg tacgctgtga ctggggacgg 2209321 atttccagaa gagccgaaag caggagaaat ccctgtgaca tagtctgtct catcatgaat 2209381 gatatccata tcctcgaccg ttgtgcccac atcttcagcc gtgatgtatc tgccattcag 2209441 tccttgaata tagcggccaa acgcgcggaa catttcctca tttttgtctt tgcgcggatc 2209501 gccgataatg actgtttttc cgccgccaag gtttaagcct gccgccgcgt tcttataggt 2209561 catgcctctt gccaatctga gcgcatcttc aattgccgct tcttcatttt catatgtcca 2209621 cattctcgtt ccgccaagcg ccggaccaag cgttgtatca tgaatggcga taatcgcttt 2209681 taatccagat tgttcatcct ggcagaatac caattgttcg taatcgtatt tctccatata 2209741 tttaaaaagt tccatgttcg ttcctcctaa tgtgtgtatt cttcagatgc gcatattgcc 2209801 agcgcaatgg aatacagttt attttcagca gagtccgctc tgcttgttaa agcaatcggt 2209861 gcttttgctc ctgtaatgac agccgccacg ctggccttgg caaaataaat cagtgattta 2209921 tataaaatat tgccggcctc aattgttggg acgagaagga tatctgcgtt gcccgctacg 2209981 tctcccgaaa tttttttctg ggccgcggca atttgtgaaa ctgcgttatc caaagcaagc 2210041 ggtccatcaa caatgcagcc tttgatctgg ccccttttgt acatttgagc tagagcagct 2210101 gcattcacgg tcgcttccat tttagggttc accgtttcga ccgctgcaag ggcagctgct 2210161 tttggcatat tgttccccac tgcatgggcc acatgaacgg cattttgcaa aatctgccgg 2210221 agctcttcca gcgaaggagc aatattcatt gccgaatctg tcacaaacat cagccggtca 2210281 aaatccggta tatcgaagac agccacgtga gaaaggacac ttgctgaccg aagcccctcc 2210341 tgtctgttca ataccgcttt aagcaaaaca gaagtcggca cattgccttt cattaaaacg 2210401 tccgctgttt tatgatgcac agcacgaacc gctaatttcg ccgattcctc aggagtattg 2210461 gcatggacga tttccacttg atgcccttgc atggatgatg tcagctcgtt cagttttttg 2210521 ctgtcgcccg ttaacaagaa acgggcggat aggtgctcgg ctgccagctt tacagcccgg 2210581 atcacttcct catcctcagc atgagcaacc gcaatggtct tatttttgtg tatcgacgct 2210641 ttgccgatta aatctttcag cttcatctgt taccaccttt cttgtttcga ctccgccttt 2210701 tattatgcaa gttccatgcc agctcttaag ggtgctgtca taccaggtat accgaaacat 2210761 tcgtgcagat gtttgcgttt attctgcaaa ttattgcatg ccttcatttg caaggccata 2210821 tttatccatt ttgtaatata aattccgaat gctgacaccg agagcttttg ctgtttttgt 2210881 ccggttaaaa tgatgctttt caagcgtttg ctggatcaaa tgcgcttcaa atttttctac 2210941 tgcgacagac agcttttcgc cttcaatatc cggaaaatca aaacctgttc cctgatctgt 2211001 gtcattttct ttttgctcaa gttcgaatac aggcaagtga tctttttcaa tccattccat 2211061 atgcggattc agaaaaatca tggctcgtcc aaggacattt tcaagctccc ggacattccc 2211121 aggccaatgg taggcagata aggcgcgcaa ggcttgctgt gagagccctt ttacattcct 2211181 gccgtaatcc cggttgatct tttggataag tctgacgctc aatgcttcaa tgtcctccaa 2211241 ccgctgccgc aaaggcggga tggagatcgg atagcgattg atccggtaat acaggtcttc 2211301 ccggaatgtt ccgtccgcca tcgccttttc aatatttaca tttgtcgccg cgatcactct 2211361 gacgttgaca gggatcgctt tcgtgccgcc cactctgacg atttcctttt cttgaaggac 2211421 gcgtagcaat ttggcctgca tattttgtgt cagctcaccg atttcatcta agaaaatact 2211481 gccgttattt gcttcctcaa ataaaccctt tttaccgccg cgcttcgctc ctgaaaacgc 2211541 accatcctca tagccgaaca attctgattc gagcaggttt tcagaaaggg ctgcacaatt 2211601 cacgcgaata aatttattgt atttccggtc actttcgtta tggatggcat gggcgaacag 2211661 ttcttttcct gttcctgatt ccccgcgcag caagatggtt gccggtgttt tcgcaccgag 2211721 cttcgcctgc tcaagcgcaa ccagcatttg ctcgcttttg ccgataatgt cgtcaaacgt 2211781 gtatttcgct tcaagcgtgc gaataatttg tctggcgcga ttaagctccg ctgtcagcat 2211841 tttaatttcg gaaacatcgt gaatcacgcc gacgctgcct ttcaaaatcc cgtccacaat 2211901 caccggtgct acattaacga tcacttcttt ttcattcggg ccgaccttca ttctgacacc 2211961 gcggacagga cgtcttgttt caagcacctt taaatgcatg ctttcgcctt cggaaatatc 2212021 agtgtttgca ggcttgccga tgacttcttt ttcagaaagc cccgtcattt tcgtatacgc 2212081 tttattgatt agcaggccga tgccgttttc atcaacgaca gaaatcgcct catcggagga 2212141 ttgaataatt gcctccagca tcgtacggac ctgctttaag ttggtcactt cctctgccag 2212201 ctcgaccgca tcagtgatat ctttaaacac acaaagagcc ccgagcagac gtccgccttc 2212261 atcaataatc ggcagtcttg tggtcacaat ttgcaaatga tcgcctaaca gctgcttctg 2212321 gttgtattca ggcactcttg tttttaaaat ccgcggcatc ttagtgctcg gaatcacttc 2212381 ttttattggg cgcccaatga cttcctcacg tttttttccg accatttttt cggccatatg 2212441 gttaaagaga atgatttctt cattgatatc aataaaaatc attccatcat gggtggaatt 2212501 aaaaattctg tcatatttat aggtttgctc ttttagcatt tgaatcaggt gctgcttttc 2212561 ttccatcagc tgaaaaacga tgtatgccat ttttcccggc atgacaatgg tatcttcatg 2212621 ctttctttga aggagctcgt caaacacggc ttgatcgccg gtagtatgaa tgacgatatc 2212681 cggtttttgt tgtatgtaag gtttccaatc agatgatacg gcaatcccat actgttctgc 2212741 ttctttcaat cccggcgcct cggggtcttt gtcaactacg gcaatgatat ctatgatggc 2212801 tgttttaatc agaatatgta ataacgccgt tccccttttg ccggcaccta ctatcagtac 2212861 cttttgcatc ccgatacccc tttgtatgaa aaaatttgca cacctattta ttccgttgca 2212921 ataatttgca caaccctatg ttaccacgtt ttcttctctt gacaaaatat tttttccgct 2212981 ggacaataaa ggaaatgaaa agataaaggg gttttctgaa gatgagccga cttcttgcgc 2213041 ttttaatatt agtcatcccc ggggctattt ctgctttagg cattaaactg atgagagata 2213101 cacttttcgg ccatacaatc aagccatttt cagctctttg gctccaaggg ttgtcaggat 2213161 tcatcttttt tgcgatcggc ctctatgtgc tggccgggtt cattttatac agagacagaa 2213221 aacgcaatca agtcagcccg cgattcagaa aacgatagct gaaaaaaagc cggagaatgc 2213281 tccggctttt tttgttgcat tattcgtcag gcaaaacggt cttggcaatc gttttgtcta 2213341 acgcttcata gtcataataa gaaatcgtat cgtacagttc ttttcgtgtc tgcatatcat 2213401 gaagtccttc tttttgtgag ccgtgctcct tcatcaaacc aaacatccgc tcacaagctt 2213461 ttgccgccgc tcgaagcgag gtgacaggat atatcaccat gtgaaacccc atatcttcga 2213521 attcatcggc acgataatat ggcgttttcc caaattcagt catattcgca aggagcggaa 2213581 cggggatacg ctcagcaaac tggcggaatt cattctccgc ctgtagcgct tccgggaaaa 2213641 ttgcgtccgc tcccgcctca atgtaagcct ctgaacgttt tattgcggca tcaagccctt 2213701 cctgcgccct ggcatcagta cgggcaacaa caataaggga gggtgccgct tgtttaatgg 2213761 cttttatttt ttgcgccatt tcctttatcg gaactagctg tttgccattt aaatgtccgc 2213821 atttttttgg gagctgctgg tcttccattt gaacggctgc taccctggct tcaagcatct 2213881 cccgggctgt tcgggcggca tttaagacac cgccaaatcc cgtatcgata tccacaagca 2213941 aaggcagatc agctgcacgc acaagatctt tggcccgttc agctatctct gccgatgtga 2214001 tgatccctaa atcaggcagc cccctgctgg ctgtataggc agcaccggac aaataaatag 2214061 cagaaaaacc ggcttctttc gcaagcaaag cggccatccc gtcatgggcg ccgggaattt 2214121 gaagaatgtc cggtgctgac atcagcttgc ggaaacgccc ggcaagctcc tcttgtgacg 2214181 attgcttatt gacgatccac gacatgaaac aaaatccccc ttttacatgc agaacatgtc 2214241 tacgaattca tttacgcgca tcgtttgtaa tgtctcatag ctggtacagc gctcataaat 2214301 gtgtttgtgc tgtttatcag gaaaatgggt tttgagattg tcagaaaact tttccagcag 2214361 tttcggcact gcttcctctc ttcgaaaacg atggccgagg ggaaactcac attccaccat 2214421 ttccgtgctc gttccatctt taaaatgaac ctgaacggca tttgagatgg agcgtttatc 2214481 aggcttcaaa taatcctcgg tatatgtttt attttcagtc acttccattt tatcacgaag 2214541 tttatctatt ctcggatcat tcgctgtttc agcttcataa tgctgtgcgg tgatatcacc 2214601 aaaaagcaaa ccgattgctg taatgtattg gaggcagtga tcacggtctg ccggattgtg 2214661 gagcgggcct tttttatcaa tgattcggat agctgattca tgcgttctga tgacaactcg 2214721 gtcaatctcg tcaatccggt tctttacctg cgggtgaaga atgacggcgg actccgccgc 2214781 tgtctgggcg tgaaattccg caggataaga cactttaaat aacacatttt ccatgacata 2214841 agcgtcgagc ggacgggcaa gcttgatctc tttcttattg aataaaacgt cttggaaccc 2214901 ccaacccggt gcactcaagg ctgtcggata acccatttcc ccttttaacg acatcagcgc 2214961 caaatgaaca cctctgctcg ttgcatctcc tgccgcccat gatttacgcg agcctgtatt 2215021 cggtgaatgg cggtatgtcc tcaatgctgc attgtcaatc catgcattcg aaagcgcatt 2215081 tttgatttct tctcttccgc cgcccaaaag ctttgctgca acagcagttg tcgcaacttt 2215141 gacaaacagc acatggtcaa ggccaactcg atttaagctg ttttctaacg ccagcacacc 2215201 ttggatctcg tgtgctttga tcatcatctc aagtacgtcg cgtaccgtta acggctcttt 2215261 tccttcagac agcctcactc ttgatacata atcagcagcg gcaaggattc ctcccaagtt 2215321 atcggatgga tgcccccact ccgccgccag ccacgtatcg ttgtaatcga gccagcgaat 2215381 catgcagcca atattaaacg ctgccctcac aggatcgaga acatatgacg ttcccggcac 2215441 tttgcttcca ttcggcacag tcgttcctgg aacaatcggg ccaagcagct ttgtgcattc 2215501 cggataccgt agcgccaaga ttccgcagcc cagggtatcc agcaatacat gccccgctgt 2215561 tgtatacgct tcggcactag taatctcttt ctcaagcaca tagtctgtga tttcttcgat 2215621 aacacgatcc gttttcggca ttctaccagc tcctttcatg attttgtttg atatcgcggg 2215681 cccatgtaac tgacacgggg acggaagagc cgattattgg catgctgttc gatcacatgg 2215741 gcgcataaac cggacgttct cgcgctgaaa aagatcggcg tatataaagg aatcggtatg 2215801 ccgagcatcc aatacactgg ggcagcatag taatccaaat tcgggtaaag ccctttttcc 2215861 ttctccatca gccgctcacc cgcttcgcac atctcatata aacgatggtc accggcttta 2215921 tcgcataatt gctgcagcgc ctctttcatc atgagtgctc tcgggtccat ttttttcata 2215981 tacacccggt ggccgaagcc catgattttt tcttttcttt tcagttttgt ttgcaaaagc 2216041 tgctcaaaat cagatgtcgt ttttgcctcc aaaagcaaat acatcacagc ttcgtttgct 2216101 cctccgtgaa gattcccttt cagggaagcg acagccccag tcaaagcccc ataaagatct 2216161 gaatgtgtag atgcaatgac cctggccgca aaggttgaat tcggcatctc atgctcactg 2216221 tacaggacga gcgaccggtc aaaaatctgt tcttccaatg aagacggcaa tttccctgtc 2216281 atcatgtaga gaaaattcgc actgtaggat agggtttgaa gcggaagaat cggttctttc 2216341 ttattaatga tcctgtagct ggcagcagtg agggcaggca ttttcccaag aagctgatag 2216401 gcgcgttctt tgtttgcgga aggagaccga tcatcaattt gccgatcata gccagcaagt 2216461 gccgacaggc cggtacgcag accatccatt ggatgagtgt cctcagggag cagctcaagc 2216521 agacggagat gatcagcagg caggcttgag gcactgttta ttttacgttc cagcgtttcc 2216581 atttcacttt cttctggcag cctgccctcc agcaataaat ggacaagctc cagatagctt 2216641 tttgtttcag aaagttctat taaatcatag cctcttatca aaatctggct ggactgcgtg 2216701 tcaagataag aaatatgagt ttctgccgca atcacaccgt ccaaccctgg agaataatgc 2216761 tgtttctcct ccatatcctc aacctccgtt tttgcgtttt ttgtctatca ggttccgcca 2216821 agcaaatact tggaaataat cagtctttga atctcgttcg tcccttcata aatttgcgtc 2216881 acctttgcat cgcgaagcag gcgctcaact ggataatcct tcatatagcc atatccccca 2216941 taaatttgaa cggcgtctaa cgccgccttt acggctgcat cggaagcaaa ttgtttagcc 2217001 atagacgctt cttttccaca gtttaggccg cggttatgaa ggtctgcagc gtggtagaca 2217061 agatgtcttg ccgcctcagc tctagtcgcc atatcagcca gcttaaatga tatgccttga 2217121 ttggctgcaa tcggccttcc aaattgcact cgctgcttcg cataatcaac ggcatgctca 2217181 agagccgcct ctgcaattcc gagggcctgt gccgcaatgc cgatccggcc gacatttaaa 2217241 ttcgccatgg caatgtgaaa gccatccccc tctttgccaa gcaaattggc ttcaggcact 2217301 tctgcattat caaaaatcag ttccgtagta ttggagccat aaagccccag ctttctttct 2217361 ttttttccaa cggtaaaacc gggtgtgttt ttttcaacaa taaaagccga aatcccgtgc 2217421 ctgccttgat ctggagctgt taaagcaaat gtgatataga tatcagctgc tccgccattc 2217481 gttatgaata ttttcgatcc gtttaatagg tatttgccgt tctttttgat tgctgttgtg 2217541 cggaggctcc cggcatccga ccccgagtga ggctccgtta gtgcaaatgc gcccaaatgg 2217601 tctcctgacg cgagatttgg tatatatttc atcttctgtt cttcgttgcc gaaatacaga 2217661 atcggattcg tgccgactga ggtatgaacg gagagaatca cgccgacagc cgcgctgatt 2217721 ctagaaatct catgaattgc caaaatataa gaaacaacgt ccgctccagc accgccgtat 2217781 tgttccggca ccggtattcc catcagtccg tgtttaccca tttttttgat cagctgaaag 2217841 ggaaattcgt ccgttttctc catgatttcc gcagcgggag caatttcttt tcgtgcaaaa 2217901 tcacgcacca tttttcgcat catgacttgc tcttgggtta catgcaactc ggccaccccc 2217961 ggatggaata gacttcagga agtcttctcc tcatagtcat aaaaaccgcg tccgctcttt 2218021 ttgccaagcc agcctgcttt gacatacttg cggagcagcg ggcaaggacg gtatttggaa 2218081 tcgccaaggc ctgagtgaag gacttccata attgataaac acgtatccag tccgataaaa 2218141 tccgctaatg caagcggacc catcggatga ttcatgccca gcttcatcac ttcatctatt 2218201 gcctccggct tcgccactcc ctcatacacg caatagatgg cttcattaat cattggaaga 2218261 agcacacggt tggaaacaaa cccaggaaaa tcattgactt ctaccgctgt tttccccatc 2218321 ttttccgcta atgccataac atctaaggcc gtttcttctg atgtagccaa gcctcgaatc 2218381 acttctacca gcttcattac agggacggga ttcataaaat gcatgccaat aacccgttga 2218441 ggccggtttg ttacagcagc gatttctgta ataggcaagg aagatgtatt gctggccaaa 2218501 atcgtatgag gcgggcaaat gcgatcaagt gttttaaaca tctcagtttt tgccgccatg 2218561 ttttctgcga tagcctcaat cacaatgtcc gcatgctctg cctcctcaag tgtttgagaa 2218621 atcgaaatgc ggttgattac gctcttcact tccgtctcgg tcctttttcc tttctcagca 2218681 tcacgggcca gctgtttctt cagccgtttc aatcctgcct ccgcggcctc tggattcaca 2218741 tcatacatcc gcacataaaa gcccgcgtcg gcggctgttt gagcaattcc gctccccatc 2218801 tgacctgcgc cagctaccat gatttgtttg atttccattc aaatcccctt tttcatcatg 2218861 ttttaatgaa cctgcactaa gacggcgtct ccctgtgctg ccccgctgca aatagcggca 2218921 acgcccagac cccctccccg tcgctttaat tcataaacaa gcgtcatgag aattctcgca 2218981 ccgctcgcgc cgatcgggtg gccgagcgcg atcgcaccgc cattcacatt tactttttca 2219041 agatcgaaac ctacgatttt ttcacatgtc aaaacaactg aagcaaaagc ttcatttact 2219101 tcaaacaagt caatatcttg gacagttaaa ccattctttt tcaggagctt gttaatagca 2219161 aaccctggcg ctgccgccag ctcgtgcgct ggcattcccg tagttgaaaa accaagaatt 2219221 gtagccagag gccgtttgcc aagctcagca gctttttcct cagacatcag cacgaacgcg 2219281 ccggctccgt cattgactcc aggagcattg ccggctgtga tagaaccgtc acttgcataa 2219341 atcggagcaa gttttgcgag ctgatccaga cttgtgtcac ggcgaatcgc ttcatcttta 2219401 tcaacaacgt ttggttttcc ttttcgaccg atccagttga cgggaacaat ttcatcctga 2219461 aacttccctt catcggcggc cttagctgcc cttgcatgac ttctcaacgc ccattcgtcc 2219521 tgctctcttc gtgagattgc atattccttg gcagctgtat ttccgtgaac agccatgtgc 2219581 acctcgtcaa atgcgcacgt taatccgtca tacaccatta agtccctaag ctcgccgtcc 2219641 cccatccgtg ctccccagcg cccggcggga acggcatacg gaatattgct catgctttcc 2219701 atcccccccg caacaagtat gtccgcatcc tgcgcccgaa tcatttgatc acataaagtg 2219761 acagcgcgaa ggccggaagc acagacttta ttcagtgttt ctgacggcac actccaaggc 2219821 attcccgcca gacgggcagc ttgacgggaa ggtatctgcc ctgagccggc ctggacaacc 2219881 atgcccatga cgtttccttc tacatcatct ccagagactc cagcctgttg cagcgcctcc 2219941 ttcatcacaa tgcccccaag ctcagcagct ttcacctctt tcaaaactcc gccgaatttg 2220001 ccaaatggag ttcttgcagc acttacaatg actgttttcc tcatggtttc acctcattca 2220061 gaagatagac agcgcttaca atttctagtt gtcttctatg aatgtatgct ttgaaacggg 2220121 catgaatgaa tgaaaaaaga aggctgcgtc aaacagcctc cttctaacaa ctattcattt 2220181 ttcagcaatg ccgaagcctt ttctggaaag tcggtaaaca tgccgtctgc tcccgcttca 2220241 atgagacgct tcatatcttc cggacgattg actgtatacg gccttacctt aatcaaaccg 2220301 ttcctcattt tcttcagtac ttcatctgtg acccctgggc tgtttatctt cgggtgatag 2220361 ccggaagccg gaatagacgc gatatatcga tctgcctgat aaagcacatc tgaagttaat 2220421 actgcccgtt cgatatgcgg tgcaagccgg gcgcacagcg ccaagctgtc atgattaaac 2220481 gtggatagga tgactctgtc ctctacatta aatcgcttca ctgcctccag cactttttct 2220541 tccattccct catagcggat cacgctgttt tttaattcaa tgttgatgag aaaatccttt 2220601 tttaccgccc acgagagcac atcttctagc agcggcactt ttatatcgct gtacgcttga 2220661 tcgtgaccag cggccgcatt cgcagtcttt acctcatcat aggctgtatc cttcacgaat 2220721 cctttaagtg atgtcgtgcg attaagtctt tcatcatgaa ttacaacaat gcgtccgtct 2220781 ttcgtcagct gtacatcaag ctctatccca tccgctccgg cttcaattcc tttttcaaat 2220841 gcaagcattg tattttcggg aaattgacct gatgcccccc ggtgggcaaa aatctttgtc 2220901 atcgtttcac ctcaaaccct aaagttttct ccattatact tattttgtcg gctccactct 2220961 aggattaagg ctgtatcaat ctactgatca taataagaat caatgccatt gacaatcgca 2221021 tctgcggcct tttgctggta ttcttcactt cccagcttgt ccgcgtcaga gctgttcgtg 2221081 ataaacccaa gctccgccaa cacacttggc atttgtgaat atgtaatgac gtaaaagtct 2221141 gattctttca cgcccctgtc tctcgtttgt aaggaagaaa cgagctgtga ctgaatatcg 2221201 gatgccagac gccggctgtt ctccccttca taatcagatt gaaaatacgt ttctgttcct 2221261 gaagctgaag caacccctga attcacatga atgctgacaa aaaggtcagc ctgattggca 2221321 cttgccttag ccactctttc ctccaaggtc agaaaatgat cgtcagaccg ggatgcaaca 2221381 ggattggctc cctcctcttt tagtttgtct gtcacatgct ctgagacagc caaattaata 2221441 tccttttcaa agagcccgtt tccgaccgct ccactgtctt caccgccgtg tccggcatca 2221501 atatacactg ttttcccttc tatcggctct gctgcctgtg cacaaggcgc gagcgtcaaa 2221561 gccaatccgc acagcgccaa gctcctccat aacattctca acttactccc tccggtcacg 2221621 agttctttcg cagctgaata tcttccagct gtaaagttcc attatccttc tttgtatatt 2221681 tcaccaggac atgtgtctga tctggcagtg attcacattc atcacgttta tccttcggaa 2221741 cttgtatcat ggtttcttct ccattaagag aaaccgcaat cgtatgagga tcagccgagc 2221801 caatgtattt tccctcttcg gtaaacctcg gcactgagtc atccgcactt gcaacactgc 2221861 accccgaaag aaagagcgca gtaaacagca aaagaaccgt ttgtttcaca tgaccacctc 2221921 ttcctgatgt ttggctttta tctttgacca gaatggagaa tttgtaaaga caacgcgaat 2221981 gcaggcgagc aagttccatg attttcaaaa gggctatacg acccgatcat ttcctgttgt 2222041 tagaaagata acgagcagat ttgtctatga ggatggctct aattgaggcg ccaattagaa 2222101 aaaattagcg gaaagaagca actttttatt cattttaaaa aatttgagaa tagggtgagc 2222161 aaatcgtttg acgggtgggt cagccaagcg taacctttta aaggatattt actttattga 2222221 aagaagttaa agccatgaaa aaattcgttc tgctgctggc ggcagctgtc atcacatgct 2222281 ccatcggcca ccaaatcagt ggcggctaca aaggccccga aaaagagcgg ccaaaacatc 2222341 actctgcact caagatattc agtcggtaaa gcagatcaat tgcattaatt tttacatata 2222401 ggctagaata tgtgcgaatc caaacgaaag aagatgatca aatgaatcct aagtataagc 2222461 cactttttga accatttacg tttaaaagcg gcgttacaat caacaaccgg atcgcagtag 2222521 caccgatgac tcattacgct tctaatgaag acggtacaat atctgaagcg gagctcgact 2222581 acatcatccc ccgttcaaaa gagatgggaa tggtgattac agcctgcgca aatgttacac 2222641 cggacggaaa agcattcccc gggcagccgg ccatccatga cgattccaac attccaggtt 2222701 taaaaaagtt agcacaagcc attcaggcac aaggcgctaa agctgttgta caaattcatc 2222761 acggcggtat tgagtgcccg tctgagctcg ttcctcaaca ggatgttgtg gggccaagtg 2222821 acgtgtttga taacggcaaa caaattgctc gcgcattaac agaagaagaa gtggaaaaca 2222881 ttgtgaaggc gtttggagaa gcgacaagac gcgccattga agccggcttt gacggtgtcg 2222941 aaattcacgg tgcaaacggc tacttaattc agcagtttta ttctccgaaa accaaccagc 2223001 gcacggatcg ctggggagga agcgatgaaa aacgattagc cttcccgctc gctattgtcg 2223061 atgaagtgaa aaaagccgct tcagaacatg cgaagggtgc attcttagtc ggctaccgcc 2223121 tgtctccgga agaacctgag acaccgggat tgacaatgac tgaaacttat acgcttgttg 2223181 atgctttagg ggataaagaa ttggattatc ttcatatctc actgatggac gtgaactcaa 2223241 aagcgcgccg cggtgcagat ccgactcgca cacgcatgga cttattgaat gaacgtgtcg 2223301 gaaacaaagt gccgctgatc gccgtcggtt ccatccattc cgctgatgac gcgcttgccg 2223361 tcatcgaaaa cggtattcca ctggtcgcta tgggacgcga aattctagtt gaccctaact 2223421 ggacggtaaa agtaaaagaa ggccgtgaaa agcaaatcga aacagtgatc aaaggcacag 2223481 ataaagaaaa atatcatttg cctgaaccgc tatggcaagc aattgtgaac acacaaggct 2223541 gggtgcctta taaagattaa tgtgcaaaga ctgccgaaac gattcggcag tcttttttcc 2223601 ctttatataa atagtttgtg tacacatcta aacagcaaaa gaaagagctc cccaccaact 2223661 tcgaaaagaa aatccaggaa aaacccctca cgctttcttg cttttttctt tttcattcgt 2223721 acgtctcctt tttacatgaa tacgccttac ttacgatttt gcaggagaaa ggtttcattt 2223781 tataacggac acatctaggg tcgatcatgc ttcgtgatcc tataagatgt atgaatggac 2223841 caagagtgca ggtaataccg ccatttgctt tccttacttt tcaaacctat cctttactat 2223901 atgcggatac ttaatattct tctcccatac tacaaatgtc cccaaaacaa aacgcctcct 2223961 atttatcagc gcaaactaat aaataaaaga cgtttgattt aatgaccact taataagctc 2224021 atgtttaaga agccttatgc tctaacctca gcttatccgc aaccattgca atgaattcac 2224081 tgttggtagg tttagctttt gtcatgctga cagtataacc aaacaacgag gaaatggaat 2224141 caatgtttcc tctgctccat gccacttcaa ttgcatggcg gatcgctctt tctacacggc 2224201 ttgcggttgt gttaaatttt ttggcgatgt ccggatagag gacttttgta atgctgccga 2224261 gcaattcgat gtcattgtat accattgaga ttgcttcgcg cagatagaga tagcctttaa 2224321 tatgggctgg gacgccgatt tcatggataa tgcttgtgat gctcgcgtcg agatttttct 2224381 tctttggttc aggctggctg ctgcgtataa tactgctttg cgatgatggc gcacgatgcg 2224441 tcacactgct ggcatttccg ctgacctggc ggatatggcc gacaaggttt tccatatcaa 2224501 acggtttgag aataaagtag gacgcgccta aatcgacggc ctttttcgtg acatcttcct 2224561 gcccaaaggc tgtcagcata atgacattcg gctgtttttt cagatctgat tccctcagcc 2224621 tctctaaaac cgcaagtccg tctagatgcg gcataataat atctaatacg agcacatcgg 2224681 gatctttttc tttaaacagc gacaggcatt cctgtccgtt ataagcaacg ccgatcactt 2224741 ccatgtcttc ctgtccttct atatattcac ttaacaggct taccagctct cgattatcat 2224801 cagcaacaca aactttaatt ttctccacgt ttcttcctcc ccaaatgtag ttaacaggat 2224861 tcacccttgc tacatgttta cattcgacaa aaccgctata taccctctaa aaaaatcata 2224921 atcaccaata ttagtggcat atctttgtta ttctatgttt ttctctgttt ttcgactaaa 2224981 aatgaaattt gacaaacaag gaaacgtgaa tttgtcgaaa aatcttcttt tgtatatttt 2225041 accgtatgta ttctgagaag tgaagaggga tcaaaataaa aaaactgccg gaaactccgg 2225101 cagtcagctt gctttttctt ttccataaat atcgattcct gcttctgaca gcatccattc 2225161 aatatgaaca ccgtagccgc ttgtcgggtc atttacaaat acatgggtga cagcaccgat 2225221 cacttttcca ttttgaatga tcgggcttcc gctcatcccc tgtacgatgc ctcctgtttc 2225281 tttcaacagt cttggatcgg taattttcaa caccattcct tttgtcgcag ggaatttttg 2225341 cggcgttgtg ctgacgattt caatatcgaa tttttctact ttgtcatcat caataaccgt 2225401 taaaatttca gccggccctt ttttgacttc ggtagaaaac gcaaccggca atgcttgatc 2225461 tgatatgttg ttttgaatcg gctgatgcag tgtgccgaaa atcccaaacg ggctgtttct 2225521 gttaatatcc ccgatcgttt tgcgttctga ggaaaatcgc gccagttttt ctcccggatt 2225581 accgcctgtc cctttttcaa ttgatgttac agtggattta acgatttctc cattctccac 2225641 tacaattggt ttctttgtgt ccatatcgga aatcacgtgg ccaagtgctc cgtatttttt 2225701 tgttttcggt tcataaaagg tcatagtgcc gatgccagca gcagaatctc tgatatataa 2225761 cccgattctg tatttgcctt ctccttcatc cttttctggg atcagcttcg ttttgatttt 2225821 ctgtttatca cgtttgatca gtaagtctaa agattcacca gttttcccag ccttttgaat 2225881 aaatggggct acatcattca ttttttcaat tttctgtcca ttcatctcaa taatgatgtc 2225941 gcccgcttca attcctgccg tttctcccgg agattttttg ccttcacttg tattgatttg 2226001 atgaaatccg acgacaagaa caccgacgga atgaagtttt acaccgattg attgtccgcc 2226061 aggtataact tttaaatcag gaagaacatg cacttttgtt tttttaattg gaaatccggc 2226121 aagatcatat accaattctg actcacctga ttttttgccc gtcaccttga tttcatgcgg 2226181 atctttcttt actgtaaacg cttctgagga ttctgatgtc tgagcgttta ccgataaact 2226241 cgtttcaatc gcttgtgttt gggtttcaaa tactctcatt tgcgttggaa tcagtaaata 2226301 ttcttttagc ggtttgcata aacctacact taataacgaa acaaggagaa ttaaacctac 2226361 tgcttttctg atgttatcgg gcattcacta cttcactctc ctcgctccta tcccacacct 2226421 tctttatgac ttgctgctac atcatttaat tttgccttct gacggcttat ttataactgt 2226481 catatgaaga aaaacattgg atatactgat gaacgaatgg atgtgcacga aaaaaataag 2226541 ctgcgcttct cgcgcagctt acccagttgt tttgacttga tccgcttgtt ttaaaagttc 2226601 tttcgcatgg cgtttcgtta agtcggttac ttcgacacct gcaatcatgc gcccgatttc 2226661 cgctaccttt tcctgcttag agagcggctt gacacgtgtc gtcgttctgc cgtcttttaa 2226721 ctccttcgca atataaagat gcgtatcggc catggcagcc acctgaggca ggtgtgtaat 2226781 gcacagcact tgtgatccta ttgacacctt atggatcttc tcagcaattg cctgtgcgac 2226841 cctgccgctt acaccggtat caacctcgtc aaaaatgatc gatgtcacat cctgttgtga 2226901 ggaaaaaatg ctttttatgg caagcatcac ccgtgacagc tctccacctg aagcgacttt 2226961 cgaaagggat ttcagcggct cgcctgtatt ggttgaaatt aaaaacttca ccaggtcaat 2227021 cccttgttca gtcagctgaa cgggctggcc gtttacaagc ggcgcctctt cattgcgtga 2227081 cgctgttctg accttaaatt ccgtatcaaa agttgatttt tccatgtaca ggctttttaa 2227141 ttcccgatga atctcatcag ccagcttttt cgcccatgtt tttcggattt gtgacacatt 2227201 tgccgcttcc actgcgacat ctttgccgac ggagtcaagc tcctttttca agctttgaag 2227261 gtggctgtcc ctgttttcaa tttggtcaat ctcttcttca attttagaag catattccaa 2227321 aatgtcttca acagtggcac cgtattttcg tttcagctgt ttgatttcat taagtcgcgt 2227381 ctcaatatag ttcaggcgtt ccggatcaaa ttcaagctca tccagcatat ttctcatctg 2227441 aaatgtggca tcctcaagca aatagtagga gttcgaaaca ctttcagaca tttttttcag 2227501 cggttcgttt atatcagata tatcttcaag ctgcgctgat gccattccaa cccagtccaa 2227561 tccgccctgc tcactgcgaa gcgcgttata tgcattttgc agcgactcat atatcttctc 2227621 aaagtttgaa atttgctggc gctcttcttg gagctgttca tcttcgttaa gctcaagctt 2227681 tgccgattcg atttcttcga gctgaaattg aataagatca agacgatggg ccatttcctg 2227741 ttcgctttca gaaagctgct taagcttttt gagcagcttc acataccgct ggtacccttc 2227801 ctgatacgtt ttgagcgcgc tttccacttc ggccccggca aacttgtcca aaagctggag 2227861 atgattttcg tcttccatta acagctggtt atcgtgctgc ccgtgaatat ctaataaaag 2227921 cctgccgatc tctcttagtg aagcaatcgt gacaagcttg ccattgacac ggcaaacgct 2227981 tttcccgctc gtgctgatat cccttctcat gacgatcatt tcgtctgaaa cgtcgattcc 2228041 ctgctcagcg catacgccta aaacaggatg gccgctctcc aacagaaaca gcccttcaag 2228101 ttcggctttt gcttccccat atctaacaaa ttcagatgat ccgcggcctc cgactaaaag 2228161 agaaatggca tctatgatga tggatttgcc ggctccggtt tctcctgtta aaaccgtaag 2228221 cccgcgttca aaagaaaccg tcagttcctc aataatggca aagtttttaa tcgatagttc 2228281 agctaacaaa cagcattaca cctcttatct ttgttagatt ttctgttaca gcagttcaag 2228341 gagcctgttt tttacgcctt ctgtatcttc aggagtccgg caaataatta aaatcgtatc 2228401 atctccgcaa atggtcccca tcatttcatc ccagtccaaa ttgtccatca gcgccccgat 2228461 tgcctgggca ttgcccggca tcgttttcag cacaatcata tggcttgctg agtctatttt 2228521 cacaaatgcg tccatcaatg cccgctttag ctttgacagc ggattgaaac gctggtccgc 2228581 cggaagactg tatttgtaag aaccattatt tgtaggcact tttacaaggt gaagttcttt 2228641 aatatcccgt gataccgtgg cctgcgttac tttgtatcca tcctgcttta gcatgtcgac 2228701 caattcatcc tgcgtttcga tttcattgct tgtaatgatc tctctgattt taatatgcct 2228761 ctggcctttg ttcatgtaag cacctctatt tccaagctta tctgttcttt tatgttatat 2228821 gattctctgc acattgtaca tgaatgcaga aaaaaggaat aatagcgccc tattattccg 2228881 gtacatctgc ttttttttct tttaacgtct tatgtgcttc ttctacaacg cgcatgatct 2228941 cttcttccgg cagttcctgg ccttcctgtc cctctcccgg ccaatgcaaa tgaaggagaa 2229001 actcaatatt tccgtctcct cccgtgattg gagaaaatga caagccttta cagatatagc 2229061 cttcagcggc agaaaaactg atcattcgct tgagcacatc agcatgcact ttaggatctc 2229121 taacaatccc ttttttgccg acggattccc gtcccgcttc aaactgaggc ttaactaaag 2229181 ccatgcagtc gctgcccggt acgagcaaag tccttaggac aggcaggatg agccgcagtg 2229241 aaataaagga cacatcaatt gtggcaaact ccggcatgcc ctttgtaaag tctgccggtg 2229301 ttgcataacg aaagttcgtc cgttccatca cgacgacccg ttcatcctgt ctaagcttcc 2229361 atgcaagctg attatagcct acatccacag cgtatgactg tttagctcca ttttgcaaag 2229421 cgcagtccgt aaaaccgccg gtggaggagc caatatcaat cataatttta tctttgacag 2229481 agacgggaaa ttccttcaac gctttttcga gctttaagcc gcccctgctc acatacctca 2229541 gcgggtttcc tttgacagtt aacggaaggt cgcggtcaat tttttctcca ggcttgtcca 2229601 agcggttttc gtttgaatag acgatccccg ccataatggc tcttttggct ttttcacgcg 2229661 tttccgccag ccctctttcc actaataata catctaatcg ttctttcttt gacgtcatga 2229721 tccaattcct ttgtgtgtct ttggtggcat cagtaatcta atacgatttg ccacctgctg 2229781 ttttgtcagt ccaatttcct caagaagcgc tgttacactt ccgtgttcaa taaaccgatc 2229841 aggtataccc attctgtcaa tcggagtatg atattcacct tgatcatgag cgaattctaa 2229901 aatcgagctt ccgaaaccgc cttctaagac cgcttcttca attgttaaaa ttggcaagcc 2229961 ttcttttagg atactcttca tcatcttttc atcaatcggc ttaataaaac gcgcattcac 2230021 aacgcgcacg gaaaggcctt ctttctgcag ctcttcggct gcttcaatcg ccatttcgat 2230081 tgttgtgccg aatgttaaga tgacagcatc gttccctgga cgcagcacct cccacgtacc 2230141 gatcggaatc gttttcaact gttcatccat ttttacgccg agtccgtttc cgcgcggaaa 2230201 acgcattgct atcgggcctt cgtcatagct aagtgctgta tgaaccatgt gctggccttc 2230261 attttcgtct ttcggcatca ttaagaccat gtttggaatg tggcgcataa acgcaatatc 2230321 aaacacgcct tgatgtgtct ctccatcagc gccaacgagt ccagcacggt caattccaat 2230381 aaacacatta gcgttttggc ggcagatgtc atgaacaact tggtcatatg ccctttgcag 2230441 gaaggttgag taaatcgcca aaaacggctt cataccctgc attgccatag ctgcagccat 2230501 tgttgcggca tgctgttctg cgattcctac gtcgaacatc cggtcaggga attcctttgc 2230561 gaagccttca agctttgaac cgacaggcat agccggcgta atggctacaa tgcgtccgtc 2230621 ctcgcgcgcc attcgctgca cagttccgct gacaagaccg ctccacgaag gagctgcggc 2230681 tttcggcttt acaaagtcac cggtattaat tttatatggt ccggtaccat gccatgtccc 2230741 aatcgtatcg gtctcagccg gtttgtaccc cttccctttt ttcgtaatga cgtgcagaag 2230801 aacagggcct ttcgtttttt tggcgtattg aagattctca atcagctcat gataagaatg 2230861 tccgtccact gggcccaaat acgtaaaacc gagctcctcg aaaaacattc cggagacgag 2230921 catgtatttc aggctgtctt tgacccgttc cgccgtggcg gcaagcttgc ccccaactgc 2230981 cggaatcttt ttaaataagt attcaagctc atctttgacc cactggtatt tccccgcagt 2231041 gcggagccgt ccgagcatag agtgaatggc accgacgttt ggcgcaatac tcatttcatt 2231101 atcattaagg atgacaatca tgtctttttt ctcgtcgccg atgtggttaa gggcttcgag 2231161 cgccataccg ccggtcagcg cgccgtcacc aatgatcgga ataatatatt catccgttcc 2231221 tttaatatca cgggcagctg ccattcccat cgcgcctgac agagaagtcg agctgtgccc 2231281 ggtttcccaa acatcgtgct cgctttcact ccgctttgga aatccgcaaa gccctttgta 2231341 ctggcgaagc gtcgcaaatt cttttccgcg tcctgtcagc agcttatgga catacgactg 2231401 atggcctaca tcccataaaa atttgtcttt cgggctgtta aattccttat gcagggcaac 2231461 agtaagctct acgacaccta agtttgggcc gatgtggccg ccggaagcgg ataaacttgt 2231521 aattaaaaac tgacggattt catcacttaa tttctctaat tcatcaatgg acatgttttt 2231581 taaaaacgac gggtcctgta ttgataaaag atccaaagcg gatcaactca ctttcagcat 2231641 gaatttctgc aatgatacat gtcttttgca tgccgagctg acaataatct cagacataaa 2231701 aaaagacaaa cgcgcttttc cttttcattt ttcatataaa ctgcttacat tttaccatac 2231761 ctcgtgcagc cgcttcaaat taggatcgtt ttagtgatct cttgccgcaa ttaaatcaca 2231821 aagctcatat aaaaggtctt tttgaagaga gagtccgccg atcaatcgct tcgcctcttt 2231881 tatatgaaca tccaatttat gtttggcccc ttccaatgaa agaagcgacg ggtatgtcga 2231941 tttgtcattt gtggtatccg agccgacacg tttgccgatt ttctcttcac tgccttctaa 2232001 atctaaaata tcgtctctga tttgaaatcc gattccaatg tggctgctga aggtacgcag 2232061 tgtttcaatg tcttcctcag gcgcatcagc caaaatagca ccggcgatta cacaaaagcc 2232121 aaggagcttg gcagttttcc gttcatgaat ggattcgagc tcttcaagcg tgacttgtcg 2232181 gttttccgct tccatatcag ctacttgccc accgaccatg ccttcggtgc ctgccgctga 2232241 aatcagttca ttcacaagcc gcaggcgctt ttctgctgac acctcgtctg acacgtggga 2232301 ggtaatcagc ttaaagcttt ctgtgagcag cccgtcaccc gctaatactg ccgtcgcttc 2232361 accaaacact ttatggtttg tcggcttccc gcggcgcaaa tcgtcatcat ccatgcatgg 2232421 aagatcatca tgaattaacg aatacgtgtg aatcatttcg acagcacagc ccaccggaat 2232481 gccgtctttt tcgctttttc catatgcatt taaaacagcc agtacaatca gaggccgcaa 2232541 ccgctttccg ccggcctgta gagaatatag catagatttc tttaatgagt ccggcatatc 2232601 aagcttttct gtatagacag aaagctgatt ttcaattgtt tttttccggt ccgccagaaa 2232661 gctcgttaat ttatttgtca ccttcgtctt cctcctgaac actgaaaggt gccagttcgc 2232721 cgtcttcttt taaaatgaag tccatttgct tttcgacttt ttgcagcttt tcatggcaca 2232781 tttttgacag agccatgcct tcttggaaat agttaatggc ttgctctaga ggcacatctc 2232841 cctcttcaag ctttgataca atgctctcaa gccctttcat cgcttcttca aatgtcatgt 2232901 tttcattttt tttcacgtct gtcatttttc ttcccctctc ttttctaata cttcacaggt 2232961 cagcacgcca tccttcagct tgatttcaag ccggtcctgc tcttctattt gactgacact 2233021 tttaatgagt ttatcttctt tataagccaa gctgtatcct ctttccatca cttgaagagg 2233081 acttagtgca ttcagcttgc caagaacggt ttgaaattgg gaatgcagct gcttcatttg 2233141 gatattcata ttttttctca gctgatttgt ttgttcctgg tatcgtgttc tcgcttgttt 2233201 cagctgttca tgaggatgca atgcctctaa tctgtacgtt tcacgctcca gctgtctgct 2233261 tttccgatct aaaagagcgg tcagctgtgc ttgaaactgc tggtacgcga ggtcaaactg 2233321 ctgctctttt tgcgcataca aacgctttgg aaaacgaaag gcataggacg attgcagcgt 2233381 ttgtatccgt tcttttttct ggccgagatg ctgctgcatt gctcttgtca ttctgacttc 2233441 cgctgttttt gtccgttcga ttaaatcagt ggtatgaggc acagcaatct cagctgctcc 2233501 tgtcggcgtc gcagctctga tatcggcgac aaaatcacta atcgtaaaat ccgtctcatg 2233561 tccgactgcc gatataatcg gaatattgga agcaaagatg gcgcgtgcta caatttcttc 2233621 attgaatgcc cacagttctt ctatcgaacc gccgcctctc ccgacaatta atacgtcgca 2233681 aatctctttt tcatttgcct cttcaatgcg cgtaacgatg gatctgctcg cattttcacc 2233741 ttgtacgagc gctggaagaa caatgacttt tacaagggga tatcttcttt ttagagttgt 2233801 aataacgtct ctgacagcgg cacccgttgg agatgtcaca accccgattg tggctggaaa 2233861 tgcggggatt tgttttttgt agcggtcgtc aaataaacct tctccggcaa gcttcttttt 2233921 taattcttcg tacgctaaat aaagcgctcc aaccccgtca ggctgcattt ctttggcata 2233981 taattgatag tttccgctcg gttcatatac ggaaattccg cctctgacca gcactttcat 2234041 tccgttttca ggtttaaaag gcagacgctc gctttgtctc gcgaacatca ccgactgcat 2234101 tcttgcgttt tcgtctttta aagtgaaata aatatgccct cgtgtgtgta tctttacatt 2234161 cgacaattcg cctttaatcc aaatattttc aaggtgagga tctacatcga attttcgttt 2234221 tatatacttt gtcagcgctg agacggtcac atacgctgct tcacccatgt ctaaaaactc 2234281 ctctcctaag cattcctgca ccataactaa agaaaacccg ccctggcttt aggagcctga 2234341 agaagcgggt atcgtgctca tattcaaggc gggtaaacat ttcgcctgtg aatatctcca 2234401 attatctatg ataacgtacg tttcgcagat ttaacagtat tatgcgcaag catcgtgatg 2234461 gtcatcggac ctactccgcc cggaaccggc gttatgaagg acgctttttc ctttgcccct 2234521 tcaaattcaa cgtctccgca aagctttccg ttttccagac ggttaacgcc gacgtcaatg 2234581 acaacagcgc cctctttgat ctggtctgca ctgatgaagt tggctctgcc gactgccacc 2234641 accaggatgt ccgctttttt cgtatgttca gtaatatttt ctgttcttga atgacagtaa 2234701 gtaaccgtcg cgttttcatt taataaaagc tggccgacag gtttgccgac aatgttgctt 2234761 cggccgacta caacaacctc tttaccggaa aggtcaatat tggttttctt caaaagctca 2234821 acaattccat gaggcgtgca aggaagaaac gtatcttcgc caagcagcat tttccctacg 2234881 tttaacggat gaaaaccgtc tacatcttta tcaggggaga tacgttcgat caccgctttt 2234941 tcagaaatat ggtctgggag cggaagctga acgagaatgc catgaaactc agggtcttgg 2235001 ttatattgat caataatgga aagcagttca gcttctgtga ggctgctgtc aaattgatcg 2235061 agcttgaaat tcattcccat tgtttctgcc gcttttttct ttcctcgcac gtaagagtga 2235121 gaagcaggat catctccaat caaaataacc gccagtccgg gagtgacgcc ttgcttttta 2235181 agctcttcta cctcttttgc caattgttcg cgtttttctc tagccgtttc ttttccgtcg 2235241 atgattgttg cagtcatttt ctttcctcct atgattgttc aatatcagat ttaatgttag 2235301 aaagaacccc gtttacaaac tttgtcgctt tgtcatcacc aaaccgtttt gccagctcaa 2235361 tcgcttcgtt catggagaca ttcaccggaa tgtcttcggc atatgccatt tcatatgctg 2235421 ccaggcgcaa aatcgcacgg tcaacattgg caatccgatc gagcttccaa ttcaccagat 2235481 gcttggagat catttcatcc agctggtctt ggtgttccaa taccccgtgt acaagctgtt 2235541 caaagaaagg atctgttttt tcttcatcca gtgcgtgttc tatggcttca ttcactgcaa 2235601 tatcgctgac atcaatttga aatagtgcct gcaaagcttt ttctcttgct gttcttcttt 2235661 tcattttctt tctcctttga tcctctttat ccgcttgtcg ttaagccaca aagagatcat 2235721 aacatatttt tttcgtatcc gcatattgaa atcaaggttt ttttacccta ttaccgaata 2235781 ttttcacaca ccttaatatg attattcgga tttcacgttc atgaagaaac tcggctatgt 2235841 aagccggctt tcttcatgct ttgaaataaa gggtaacgtg taaaaaaacc aaagggccgc 2235901 cctccccttg gtttcgtgtt aagccattta catttcttcg tcgatttgga cttcttgggc 2235961 ttttgtgtca aattgaatgc cgacgatgtg aatattgatc tcgttaatcg aaagagacgt 2236021 catatttaat aaggtttgac gaatgttttc ctgaacggat gctgcaactt tcggaatcga 2236081 aacgccaaat gtaacgacac agtatacatc gatcgtaatt ccgtcatccg ccaggtcgac 2236141 tttgacacct ttgccatgat tcactttgcc aaagcgctca acgacgcctg tcgcaaagtt 2236201 tccgcgcatt tcggcaactc catcaacttc tgatgctgca atgccggcaa tgacctcaat 2236261 gacctccggt gcaatctcaa ccttacccaa atgcgtatct tcgtgatcca ttttaagcaa 2236321 gctgttgtct ttcattcaat tcacctccgt aaaaattatg agcccattac atcatatgtt 2236381 tctaaaaatt tcgtattaaa ctctccgctc acaaatgttt cgtgttcaag cagttttaaa 2236441 tggaaaggga ttgttgtctc aatgccttcg atgacgaatt cgctcaatgc gcgcttcatg 2236501 cgggcaatcg cttcatctct cgtttttccg tatgtgatta cctttgcaat catgctgtca 2236561 tagtacggtg ggatggaata gccagggtac gcagctgaat cgacacggac accaagaccg 2236621 ccaggaggca ggtacatttt aatttcacca ggtgacggca tgaaattttt gcttgggttt 2236681 tctgcgttga ttcggcattc gatggcccag ccttcaaatt caacatcttc ttgcttgagg 2236741 ctcagttcca ttcctgaagc cactttgatt tgttccttga tcaggtcagt tcccgtcacc 2236801 atttctgtga ctgggtgctc cacctggatt ctcgtgttca tttccatgaa gtaatagcgc 2236861 tgttcattgt agtcatagat aaattcaact gttccagcac ctgtatagcc aaccgctttg 2236921 gcagccttta ccgctgcatc tcccatttgc tccctgattt ctgaatcaag ggcaggagat 2236981 ggtgattctt ccaaaagctt ttgcaggcgt ctttggatcg agcagtcgcg ttcgcccaaa 2237041 tggatcgtat ttccgtagtt atcagcaagc acttggatct caacgtggcg aaaatcttct 2237101 atgtattttt cgatgtatac acctggattc ccaaatgcag ttgccgcttc ctgctgtgta 2237161 atcttaatgc cattaatcag ttcctcttca gtgcgggcaa ccctaattcc ttttccgcct 2237221 ccgcctgcgg tggcttttat aattacagga tacccaattt cattagcaag cgaaaccgct 2237281 tcttccacat tttctataat tccctgtgaa cccggtacga ttggcacgcc ggcctgtttc 2237341 atcgtttccc gcgcaacgtc ttttgttccc atttttgaaa tggcgtcagc gctcgggccg 2237401 acaaacgtga cattcacttc ttcacataat tcagcgaaat cagcattttc agctaaaaat 2237461 ccgtatcccg gatgaatggc gtccgtgcca gtcagctttg caacactcac aatatttgta 2237521 acgtttaaat agctgtcttt tgatgctttc ggtccgatac aaaaagcttc atcggccatt 2237581 tgaacatgaa gggcatcttt atcagcttct gaataaacag cgacagtctc aattccgagc 2237641 tctctgcagg ctctgatgat tctgacagca atttctcctc tgttggcgat caatagcttt 2237701 ttaatcatgt tcagtctcct tactccgctt ttacaagaaa tagaggttgt ccgtattcga 2237761 ccagctggcc gttttctact aatacttcaa cgatttcgcc tttcacttct gcttcgattt 2237821 cgttgaaaag cttcatcgct tctacaatgc agacaactgt gttttcattt acttttgaac 2237881 cggctgttac atacgggcca gcttccggtg atgaagaagc ataaaatgtt cctaccattg 2237941 gtgaagtgat tttatgcaga ttctcatctt gctttggtgc ttcttgggca ggtgccgctg 2238001 cttgctgcgc ttgcggctga actgcctgcg gagcctgtgc ttgtacaggt gctgccggtg 2238061 cctgctgcat gacttgaacc gtgcctgctt cgtgtttttt cagttttaag gatacacctt 2238121 cattttcata tacgaattcg tcaattgtag actcgtcaat tgctttaatc agctcgtgga 2238181 tttctttgat atttaacatt caatcgcact cctatgtatg aaatttcttt ttttataggt 2238241 tactactaaa agtacatact atgttcatct tacaggagcg gacttttgaa ttcaactcta 2238301 atatgacagc aacgcaaaaa gcccgcttgt ttagcgggct tttttccctc attcttattt 2238361 agagggttca aatgtgacag cgacatcttt cattgttttg atttcttttg ccacaaggtc 2238421 tataatggct gtcgccttcg atttagagtg tttgtctgat ttgactgtaa tattgatttt 2238481 atctccttca gcattaacaa gcgcatcctc gtaaccttgt gttttaatca gcgtttccag 2238541 ctgtttttct gttccttcca cttcactgag agccgtcatt ttatcgtatg cttcgctttt 2238601 ctccttggct gttgcatcat cgcttgacac aatggcattc agctcttctc tttctttgct 2238661 tctggcatct tctaaatcaa gacggtacgt tgtaaacaaa tcatcatcgg ctgtttccgt 2238721 aacaacagtt cctttttcac tggcttcagc ggatgtttcc ttgtctgctg atgaatcttt 2238781 cgttcccttt gttccatctt cttttccttt ttcagtttct gtaccgcttt tttccttcgt 2238841 gtcttgcttg gcaggcgctt tttcagttgc gacctctccg ctgtcagacg cgcttttttc 2238901 actttgcatc tgcacggcgt ttttgctttc cggcgacatg atatagtaga cgcttaacac 2238961 cacgacaaga ctgagcattg ttaatagcca aacggtttgt tttttaagca tttatgaatc 2239021 ctcctttatt tttttagggg caaccgcaac ccggtggctt ggaacatcca ggacccgtgt 2239081 caccgcttcg ataatggttt gttttatttg aacgttgtcc actccttgag caacaacgag 2239141 tacaccgcgt atatcaggtt ttttcgtttg gacgacgaca ggtgtttctt tatcgccgtt 2239201 tttgatcatg acgatttctt cctccgatga ttggtctgta acgcttcttt ttccgccttc 2239261 tttgtcagtt tcttcagtgg ttgtattttt gtttgatttg tttttttcgt atactttcag 2239321 cgacgttgca tctacattca cgacaaccga gacatcgtcc acaccaatga ttgtttcaag 2239381 aatttctttc agttgatttt cgtattcttt ttcatagtca tcgatcgagt ctttaggttt 2239441 atcagatttt gaggctttaa acacttcggc tgttttctct ttgctgtctg cggaatgttg 2239501 tgatgatacg gccgttatcg ttttggcgtt ttcagttttc tcaggtgaag aaaacagctg 2239561 gctgacaagc ataaaggaaa ctccgagaac aaaaacgaat agaaagtaat gatatttggt 2239621 cagcttcggc ttttcgccgt ccttcgtttg tcccggaaga aactgctttt tcaatacatt 2239681 ccataatccg tttttattca ttgccgacac tctccccgcc ttccatatga accgtaattt 2239741 tctcacttcc gatttcccaa atgtccgcga gctgcgtttg tatctgtttg gcttcttttt 2239801 gttcggctgc ttcttttgtt acgtatgcat gatctgtatc aatgtggacc ggcgcgaccg 2239861 tttggaccgt tttttcagaa gacggggcca tatacacgct gattgtttta atatcctctt 2239921 ctgaatctac cttttctcct gccgtgagtt tgatgcggcc tactttatat tcatcatgac 2239981 tgaatctctc ctccgctttc ttttttagtt ggacagccat ttcttctaga atatatgcgc 2240041 gctgggaagc ttgtatttct attttttttg aattgatttg attttttatg tcggcagact 2240101 ctgactgccc gttttttgtg aggtattcaa agatgacttc ggggtctgtc ttgaaaagtt 2240161 taaaaatcgg cgtaagcatg acgacaatca agagcaggct gactaccatt tttgcgtact 2240221 tttgcatgct ggagctcggc agcagcatat caatcacaat tgcaaatagg ataaacaaca 2240281 cgatggtggt aagccattcc gttaaaaaac tcatttgcct gcctccttca tttcatcatc 2240341 atcgtgaggt ttccggctgt gattatgaca gtaaggctta aaaaaaacat gagagacaca 2240401 atggcgagag ctgcaaaaat ataaatgacg cttttgctga tgacgtcgag gcaggtgatg 2240461 acgggcccgc ctcctagcgg ctgaagaatc gcggctgcca gcttataaat aaaagcgagg 2240521 gaaagcactt tgattgccgg aaatgccgca atacagatca aaatagcgac accgagaatc 2240581 cctaccgtat ttttcagcag taaagaggcg ctgattactg tatctgttgc gtctgtaaac 2240641 attcggccaa gcacaggaat aaaatttccg gttataaatt tagccgtcct gagcgtaatg 2240701 ccgtctgtca ctgcagctga cgctccctga acagagatga cgccgagaaa gatggtaaga 2240761 aaaacagcca gtgctccgat ggcgatattt ctgagcaggt tagccagctg cgttactttg 2240821 tattgttcag tcatcgtgct gacaatgctc agaatcgctg ataaaaaaat cagcggcatg 2240881 acgatattct gaatcaagag accgctcgtg ttcatcagga agaggataac aggatgaaag 2240941 aaggcagcag atacagctcc gcctgaggaa gccaaaagcg ccaagaggag cggaatgagc 2241001 gccaggataa agctggtcat cgtctgaatc gcctcagttg catagttaat tgccacatga 2241061 aagctattaa gcgcaaggat aatcagcacc atgtacacaa ttgagtaagc gaccttactg 2241121 acggtgcttt gctgaaaagc attttgcaaa agctgcagaa tgacgcaaaa aatcgtgagc 2241181 aaaatcaatg tgcccagcag ctttccgttg gcaagcactt catgaaacaa ataagaaaag 2241241 agagctttca gccattcttg cggtgagaat gatttatcgc cattgataaa ctccattaag 2241301 ctgccttttt ggctttccgg cagcagtccg ccgtattctg tcataatgtc attccaaaat 2241361 tccccgatct tatctgtttc aagcgaggct gctgtccttt ccgctaattg ctcggctgtt 2241421 tcagcatggt cttccgtttg ttctgcatta ccagctgctt gtacaatttc tgcacggcct 2241481 gctatgatca gcacggccaa aagcaaaacc cattgaaagc gcttcaatct accgcctcct 2241541 ttcggttatg acatagaagg tataagtccg agaatcgttt cgataatgac ggttaaaata 2241601 ggcacagcca ttacgagtat taaaattttc cccgccaatt ctattttcga ggcgatggct 2241661 ccttgaccgg catcttttgt gagctgtgcc ccgaattcag caatataggc gattccgata 2241721 atctttaaaa tggtttcaac atagaccatg ttgacatttg cattaatcgc aattttttct 2241781 atcattcgaa taatgtcgta gatttggtct accaaataaa gaaaaatggc acatccggca 2241841 aaaacgacga ttaaaaacgc aaaagtcggc ttttgttctt ttacaattaa agaaaggaag 2241901 gtggcgatca gccctaaacc tacaatttga acaatgtcaa tctgcaagcc cccctatcct 2241961 tggaataaaa acacagcttt tatcttttta aataggtcat ctacaatcgt ggcgaccata 2242021 aataaaatat agataaaacc taacagcgtc acccactgag catattcttt cttgcccatc 2242081 tgatccaata tcgtgtgtaa aaaagcgacc acgattccca ctccggcgat ttgaaatatg 2242141 acattcacgt ctactcccat tttatttttg ctcccctcac gtttacatca atagaagaat 2242201 gagtaacaag cccgctaaaa agcccaaact ttttatcatc ttttcgtttt tcgcttgcgc 2242261 ctgctcagca tccgcttctg aggcttccaa atgtgtcagc gccagcttga tgtgcttttg 2242321 ctgagagatt cgatcatgaa tcccaagcgt ctcgccaaac tgcttcagca cttcgtattc 2242381 gctttttttc aaagacaggg tgtcccatac cttctttaag ctttgctccc acgccgtttt 2242441 cgcggaatca cttcccttgt ccagctgatc actgaatgcg gaaaaaagag ttgaaacagg 2242501 ctgtgcgagc tgtttggcaa tctgctgtga agcagtatga agcggtgtat ggccgtacat 2242561 gatttcagcc tcgagggatt gaagcgccgc acgcagctgg cggatttgcc gcggccgttc 2242621 tgtataaatc ttcgccatct caaaacctgt ccatgttgtc gctaccacaa tgaatacagc 2242681 gcccagcagc ttcagcatgt tttcacgccc gtcgtcctag acagcacatt tccgtctttg 2242741 tcataaattt ggctcactgt gcccggccct tttgctcttg ataattccaa atagcggtca 2242801 aaggctcttt cttcccacaa acgcttcaat gaaggccgct tcatcaggtc ggatatactc 2242861 cagccatgcg ccgatacgat tactgaaaca ccggcatgca gcgcctccag aagtgcatct 2242921 gtatcttcca tacgcccgat ttcatcgaca atcatcacct cagggctcat ggatcgaatc 2242981 atcatcatca gcccttcagc ttttggacag gcgtctaaca cgtcaattct ctgaccaaat 2243041 tgatgctgcg gaataccgcg aagacatccg gcaatctctg accgttcatc gacgatccct 2243101 gtctttacgg gcagcatgtt ttttttgccg gtgcttgaga gcctcgcaag gtcccggaga 2243161 agtgttgttt tgccggtttg gggcggtccg ataatcagcg tattcagcca gctgttttga 2243221 tataagtatg gaagcagcgg ctccgcaatc cccagctttt gccgggcaat tcgtatatta 2243281 aaagatgcga tgtcacggag gcctttcaca cctccgtttt ccgtaatgac tctgcccgcc 2243341 agtccgactc tgtggccgcc tctgatcgtg acataccctt tcttcagctc ttcttcaagt 2243401 gtatacatac tatagttgct gagccggctc aggatcagat gggcatcctc ggccgtgccc 2243461 gcataggaca aataaacagg ttgtcctctt cgaatcaatt caacagggcg gttgatccga 2243521 attctgactt cttcgatttc cagccattgt tgttccggta tttcagaaag ggcgtttttc 2243581 atggattcag ggagaacctc agcgatttca ttcaacagag cctcctcctt tctaccgatt 2243641 ggcttcttta aaatgtatga tgtgaggcag actttatgac aagcctctct ttatttatga 2243701 acacccgcca aaatcaagac aacacccgta aaaatcagaa tcagctttgc atacgaaagc 2243761 tgcccggcaa tttggtagat tccgacagtc attgtaatga taaaaatcaa cggaccgaca 2243821 atagcgagaa tgctgttaac cacaaccgcc ttccggacat cgttggtcac aagcatgaca 2243881 attgctgccg tcagctcaat catagaggat aaaactcgta atcccgccat tgttaaaaca 2243941 gtagaattga tatttccaag taaaaatttc atagcactct cccaacctcc cattttttta 2244001 tatgatatgc tctagcttgc tgaagtagtc ttgtcatttt cgtataaaag aaagattctg 2244061 tttttgggca caaaaaaagc ctgctcccat ttgggaacag acttcttttt ttctttctat 2244121 gctcttgaaa cgtaagaacc gtctgatgta ttgacaacaa gtgtgtcgcc ttcattcaca 2244181 aagaacggca cgtttacaac aagcccggtt tcagttttcg caggttttgt accgcctgac 2244241 gctgtatcac ctttaatacc aggttcagtt tcaacaactt tcagctcaac tgtgtttgga 2244301 agttcgatac caagtgtttc atcctggtac atcatgatat gcacagacat gttttctagc 2244361 aggtatttta attcttcttc gatttgagtt gcgctcagtt caagctgctc ataagaagaa 2244421 gtatccataa atacgtgctg atctccgttt gcatatagat attgcattgt tttggtttcg 2244481 atttgcgctt tcgctacttt ttcaccagcg cggaatgttt tttcctgaat cgcgccagtg 2244541 cgaaggttgc ggagtttaga gcggacaaat gccgcacctt ttccaggttt tacgtgctgg 2244601 aagtcaacga cgcgccaaat gccgccatct acttcaattg ttaatcctgt acggaaatcg 2244661 ttaactgaaa tcatgtttaa tgtcctccta tattccaatc acaaaataat aagttctttt 2244721 ggggaatggg tgattgtccg gttgccgttt tctgtaatca cgatgtcatc ttcaatgcgg 2244781 acaccgcctg tttctggtat gtaaatgccc ggctccactg tgaccaccat acccggttca 2244841 aggatagctg aagatctgac ggataatccc ggcgattcat gaacttccat gccgagcccg 2244901 tgcccggttg aatggccgaa atagtcaccg tagccttttg cagcaatatg atcccttgtg 2244961 agggcgtcag cctcttttcc tgtcattccc ggcttaatat gtgcgacgcc aagcgcctga 2245021 gcatcaaata caacctgata gatctccttc aattgatcac tgggctgacc tacagcgacc 2245081 gtccgggtaa tatcagaaca atatccttta taataagcgc caaaatcaag cgtaacaagg 2245141 tctccgcttt caatcagttt gtcactggcc acaccgtgcg gaaggcttga acgaaggcct 2245201 gaggcgacaa tcatatcaaa agaagagctg tctgctccct ggcttctcat ataaaactcc 2245261 agctcattgg caacagcgat ttcagaaatg ccgggtttca taaacgtcaa gatatgtctg 2245321 aaggcatcat ctgcaatctt cgcagcttcc tctaatatct taatctcttc actagactta 2245381 atcaagcgca acttttccac ggattcagcc acaggcacta attcggcatc actgataacg 2245441 gcgctgtatg aagcgtaagt gccatatgtc atgctgttct gttcaaagcc gagacgcttg 2245501 atgccaaacg attcaacagt gtcggcagtg gtctgaatca agctgccgcc atgttcaatg 2245561 atctcaaaac cctttacctg aaccttcgcc tgctcagtat aacgaaaatc cgtaataaac 2245621 gctgctttgt cacccgatat aacagccaaa cccgccgaac ctgtaaaccc tgtcatatag 2245681 cgtacattag tgttgcttgt aatcagcatg ccgtcaattc ccagctgtcc aaacaggttt 2245741 cttaatttct ctagcttcat cttgattctc ccccttgctg gcttaataag tagcgaacag 2245801 caagcttgta gccttcagct ccaagaccga caatctgccc tttcgcaaca ggagcgataa 2245861 ccgactgatg cctgaattct tccctggcgt ataagtttga taaatgcacc tctaccacag 2245921 gaagactgat gcttgaaaca gcatccctga tcgcatagct gtaatgactc agggcgccgg 2245981 ggttcagaac aatcccgctg tattgctcct cagcctcatg tatcgcatct atcaaatcac 2246041 cttcgtgatt agactggaag aaagtgagct ggatatgtaa ggcttcagca aactgaaaaa 2246101 gatctgtttc aatatcggtc agtgtctggc ggccgaatac ttcaggctca cgactcccaa 2246161 gccggttaac attcggtccg ttcaaaatca aaaaatgagg cacacaatct ctccttttcg 2246221 cgagggtttc tcatgtaaaa aatgttcact tctcgtgaac attttatcat actggaaaag 2246281 gattatacac tattctctat gcattcccag cgcacgtgca agcttttccg aattcagctc 2246341 attgtattca aatgaaatag aatacccgac aaacagcccg taaagcaaat aaatgcaaat 2246401 ggtcgtaata attgtatctg atgtcagttc ggtcaccgtg cgcacatctg gaaaaatcgg 2246461 attaaaaaca aaaaacacga gcagccaaag caccaagccg tataaaatac ccggccacat 2246521 tgtttttaaa cgtttcaata gaagaaaata aagaaatgct gcgccaattg aaattactcc 2246581 aatcaaaatg atgctgatta ccgttcccag cccatgtttt ttccactctc cgagtacaaa 2246641 cggctgcaat atcatattcg ggctgatttc ggaaaaatga aacaaatatg cgatataagc 2246701 aacgaaactc caaagtacgc ctccgcaaaa acctgttgcc gccaccctgc cggccattga 2246761 aacaggcggc ttttgcttct cattcaattc ttcattttgt tctgtatctt tttcgcttgt 2246821 catcatggca cctccagtta aagtgtgccc aaaaaatgaa atgtcaataa aaaagctcac 2246881 actttttggc agctgcgagt aaaatttgaa aataacgggt ataatgcatg tagaaaaagc 2246941 aaggctatgg caattttttc agcctgtcaa tctagaggtt tagcgctgtt tcctgtacaa 2247001 tagagtgaaa ggaaatggtt agcaatccta aagaaatagg caggttgata atatgtcaaa 2247061 acataaagtt ccgcccgctt acggcgggca ggctgttgtg gaaggcgtta tgtttggcgg 2247121 aaagcatcat tacgttacag ccatcagaag aacggatgga agcattgact tttttaagct 2247181 tccacgcaaa cacaacccga aactgaacat cgtgaaaaag ataccgtttt tacgggggat 2247241 cgcggccatt atcgaagcga gtgcaaacgg cacaaagcat ttgaattttt caagcgaacg 2247301 ttacgggctc gatccatctg aagacgagac acttgagcag gaagaaaaaa aatcctctgg 2247361 gctgtctatg tatctcagcc tcgcagttat aggcgtccta tcatttttgt tcagtaaatt 2247421 cgtatttaca ttggttccag ttttcttagc ggaactgaca aggccgattt tttccttgaa 2247481 cacagcgcaa atcgcgattg aaagcctgtt taagttgatt ttgctgctcg gttacatcta 2247541 ttttttgtcc atgacaccgc ttattaaaag agtgtttcaa tatcatggag ccgaacataa 2247601 agtcataaac tgttatgaac agaatttgcc aattactgtg gagaatgtcc aaaaccaatc 2247661 tcggcttcat taccgctgcg gatcaagctt tattttattt acgattattg tcggcatgtt 2247721 tgtttattta ctcgttccga cagatccgct ttggctgcgt gttatagatc gtgtcgcact 2247781 gataccggtc gtgcttggta tatcctttga agttctgcag ctgacaaaca aagtgcgtga 2247841 cattcccggt ctgaaattac ttgggtaccc gggactttgg cttcagctgt taaccacaaa 2247901 ggaacctaag gatgaacagg ttgaagttgc catcgaaagc tttaacgaac ttctcagact 2247961 cgaagcattg tctgagcaaa atcagaagcc ttctcacaac gtcatctaaa atccgttgcc 2248021 ctgctattac tttcggaggt ggacagttat gaatcatcgt gtacaaccta ttattgctgt 2248081 attaattgcg ctgggagcgt tcggtttcct ctatgtgctg gtaaccaatc ccggagaaat 2248141 ggcaaaaatg gcggtaaccg tcatcgtggc aggtatcatt atttatttta ttgtgaaata 2248201 tgtaatgaat cgaaatgcgg gcagcgaagg agcagccttc aaaaaagcgg cgaaacaatc 2248261 acggcgccgg atgaaagaac aaaaagcaaa acaccgcgcc ggacataagg gacgtgtcag 2248321 ccacctgcga agcgttccga gcgccagcaa gcctaagccg atgattctca agaaaaaaag 2248381 ccagactcag ctgactgtta tagaagggaa aaaaaataaa aagaaaaaca gagcgctttt 2248441 ttaataggtc cactgcttta aaaacagctc tgtccgtctt ttacctagct caatcagggc 2248501 tagttttttt tgttgtgtta aatgaaaatc agtggccatt acgtcatcaa cagggagaaa 2248561 aatgatattt tgttcatagc gtgacgcaat gtgccttgcg tcatgagcat ccttcatcgt 2248621 ttcaaacagg gcgccgaaca gttcaaaagc gttgcggata ttttttttcg gacgctctct 2248681 ttcacgcggc gcaagcgtga caccgatcac agggcgcttt ctttcctttg aaaacagcca 2248741 gattggaaaa ttgcttaaca cgcctccgtc gacaaccgtg gcggtgcctg tgtccgtttt 2248801 taattttatc ggttcaaaga aatacggaat gctgcagctc attctgaccg ctctggcaac 2248861 cgggaacata tctggattta acccgtaacg ggccaaatcg tccggcaaaa caatcatggt 2248921 gccgtttgtc agatcagaag caataaggcg cagagaccct ttctgcaaat cgccgaaaac 2248981 ccttatgcct ttcgctctta acagatcagc aatccatttt tctatcgtat cgcctttgta 2249041 taagccaaga cgccagtaga tggacaccca ctggagcatc tttaagggga gaaatgagta 2249101 cctctgatcc agcaatttct ctccgtccac ttcttcaatt aaagcgtgga tttccttact 2249161 ggtgtaacct gacgcaatga aagcggcaat aatggcgccg gcgcttgtac ccgcaactct 2249221 tttaaagcgg aagccttttt cctcaagcac ttcataagcg cctgcgagcg caatgccttt 2249281 tactcctccg ccggaaaaca caccgtcaat atacatctca ttccctcccc ctccatccga 2249341 tcgtttatta ccattttaag aaaacacgcg aagaaataga ccaacgaatg acgggtggcg 2249401 tcagcgtatc aaaaaagacg gcctccttcg agaccgcctt tttactgatt atgatgttct 2249461 gttttctttt ggattgattt cagatctttt ttacgggcat catcttcttc aaaatattga 2249521 acaagatccc cgatgcgatc aatactgttc cagcttaaat gatgttcgat tccttcgaca 2249581 tcgttatata ttttctcttc atcaacacca atgattctta aaaactgctc aagcaattca 2249641 tgtctgtata ccagccgttt gcctattttt ttccctttag acgttaacac gagaccgcga 2249701 tatttttcat aaattaaata ttcgtcttta tctagttttt gaaccatttt tgttacagag 2249761 gagggatgga ctgccaatgc ttccgcgata tcggaaactc gtgcatatcc tttttcttca 2249821 atcagcatat aaatctgttc aatataatct tccatacttg gtgttgtcat cgaaaccctc 2249881 ccaaaaagca ccttaacttt ataaaccatt acaagtttac actaatgaac ttgaaaaaac 2249941 aaggatgctc cgcgggtcaa aagccctgtt taccgcttat aattccattc atctgaagcg 2250001 tactttgttt cagccaagtg atgaacaaaa tcaagctctt cctgagaaag ttcatatggc 2250061 tccaaatgaa tgttaagacc tgtttcaaat ccttctttaa aggctttacg agcctcatcc 2250121 atcgtcaccc gcttttcgat gagttcatta atggcaaccg ctttattttt gaaattgcgc 2250181 tgcatccgct ctcttactct ttcacttgga tataagaaca gatcgaacag cttgtcctca 2250241 tctaaatcaa gaagaatgga gccatgctga agaatcacac ctttttgtct cgtttgcgcg 2250301 cttcccgcca ccttgcgccc ctcaaccact agttcatacc acgaaggcgc gtcaaaacaa 2250361 acagatgacc gcggattttt taagctttct ttttcttttt cagttctcgg gatggcaaag 2250421 taagcgtcca gaccgagatt tctaaagcct tgaagtatgc cttctgaaat aacccggtaa 2250481 gcctcagtaa cagtcgccgg catctcgggg tgctcttccg aaacaattac gctgtatgtc 2250541 agttcctgat cgtgcagcac acctctcccg ccggtcgggc gtctgacgaa tccgagatta 2250601 tatttatgta ctgcttcaaa attgatttcc tttttaatat tttgaaaata ccctacagaa 2250661 agtgtcgccg gattccagcc gtaaaaacgg ataaccgggg ggattttctt ttcgctgtgc 2250721 caatataaaa gcgcttcatc aagcgccata ttgaatgcag gacttgcatt gcctgagtct 2250781 ataaaccgcc aagtttcttt ttgcatttta agaccttcct taccgtttta atagaatcag 2250841 tttatcaaac tgtcgggaaa atgaaaaata ttttagttcc attatagatg acaatcacgc 2250901 tgtgctttac tataatagta tttgtcgaaa acggctctat gaccttgttt tatgaagcag 2250961 ggttttgatt ttatatgcta aaggagtaga atcacattgt ctaatatgat cgttttgatt 2251021 atttttgctg catttatcat ctatatgatt gcttcatatg tctatcagca gcgaattatg 2251081 aaaacactta ccgaagaaga attccgcgcg ggttaccgca aagcgcagct tattgatgtt 2251141 cgtgagccaa atgagtttga gggcggacat attttaggcg cccgcaacat cccgctttcc 2251201 cagctgaaac agagaaaaaa tgagatccgt acggacaagc ctgtttacct gtactgccaa 2251261 aacagtgtcc gcagcggacg cgcggcacaa accctgcgca aaaacggctg cactgagatt 2251321 tacaacctaa aaggcggctt taaaaaatgg ggcggaaaga ttaaagcgaa gaaataaagc 2251381 aaacagctgt ctggtagaca gctgttttta tttatctttc ttccgcctcg tatctgagca 2251441 ctgggtgtct cgccgctttt gtttcatcca ttctttttac aatcgttgta tgcggggcct 2251501 cctgaacaag ctccggattc tcctccgctt cttttgcgat ttgaatcata gcatcaataa 2251561 acgcgtccag tgtttccttt gattcggtct ctgtcggctc gatcatgatg cattcttcaa 2251621 cattaagcgg gaaataaatc gtcggcggat gatagccgaa atcaaggagc cgttttgcaa 2251681 tatcaagcgt acgcactccc agctttttct gccgcttccc tgataataca aattcatgct 2251741 tgcaatggcg gtcaaacgga agatcgtaat aaggcgcgag ttttctcatc atataattgg 2251801 cgtttaacac tgcgttctca gtaacagcct ttaatccgtc aggccccatg gagcgaatat 2251861 acgtatacgc tctcacatta atgccaaagt tgccgtaata cggcttcaca cggccgatcg 2251921 catgagggcg gtcataatca aacgtaaagc gcccttcttt tttgactaaa actggctttg 2251981 gcaaataagg aatcagatct tgttttacgc cgacagggcc tgagccgggg cctccgccgc 2252041 catgagggcc tgtgaatgtt ttatgcaggt tgaggtgcac cacgtcaaat cccatatcac 2252101 caggtctcgc cttgcttaaa acggcattta aattagcgcc gtcataatac agtttccccc 2252161 ccgcttggtg tacaatttcc gccatctctg taatctgctc ctcaaacaag ccgagcgtgt 2252221 tcggattcgt cagcataaga gctgcagttt cttcattcac tgctcttttt aaatcctcta 2252281 aatcaacaag ccctttttca ttcgatttca ccgtaacggt ttcaaagcct gctactgttg 2252341 ctgatgcagg attcgtccca tgcgcggaat cagggacaat gaccttcgtc cgcttgaaat 2252401 ccccgcgagc ttcatgatag gcacggatca tcatcagccc cgtccattcg ccgtgcgctc 2252461 cggcagcagg ctgaagcgta acctcatcca ttcccgttat ttcttcaagg tgtttgctta 2252521 aatcatataa aagctctaat gcgccttgca ccgtgtcttc atcctgaaga ggatgaatcg 2252581 cagcaaaacc aggaatacgt gcgatttttt cattgatttt cggattatat ttcatcgtgc 2252641 aagaaccgag aggataaaaa ccggaatcca ccccgtgatt gcgtttggac agcgctgtat 2252701 aatggcgcat gatgtccagc tctgaaacct ccggcagcgc tgcgtcttcg tcacgaatat 2252761 aggtgtctga caagaggtcc cccaattcga tttccggtac atcgagctcc ggcagactat 2252821 agccgattcg gccttctctt gaaagttcaa aaataagtgc ctggtcctga ttactcatgg 2252881 cgatccccca attcctgaat gagtgcgtca atttcttctt ttgttctcag ctctgttaca 2252941 gcaatcagca tatggcagtc cagctctgga tacgtcaacc caagatcata tccgccaatc 2253001 atgccttttg ccagcaaacg cttgttcaca gctctcaccg gctcatccag tttgatgaca 2253061 aattcattaa acatcggccc gtcaaacata acagtaaggc ctgctttttt tgcttcttgc 2253121 tttgcatagt tggcttttaa gagattttgg cgggctatat cttttacgcc gttttttccg 2253181 agagcagtca tggccactga tgctgccagc gcatttaaag cttggttcga gcatatattt 2253241 gatgttgctt tatcccggcg gatatgctgc tccctggctt gcagggtaag cacaaagcct 2253301 ctttttccgt tttcgtcttc cgtttgtccg acgagacggc ccggcacctt tctcattaat 2253361 tttttagtaa cggcaaaaaa gccgcaatgc gggccgccgt atgctgaagg aatgccgaaa 2253421 ggctgcgcat caccgacgac gatatcagac tgaaacttgc ccggcggagt gagaagacct 2253481 agcgccagcg ggttggctga aacaataaac atggatttcc cttgatgagc gataggctca 2253541 atatccttta gcggctcgat cctgccgaaa aaattcgggt actgaacgat cactgcggct 2253601 gtgttctcgc aaacggtttg gcgcaatgca tcaagatccg taacgccatc cgcagcgggt 2253661 acttcaacaa catcaatata ctgacctttt gcgtaagttt tcagcacctc tcgcgattca 2253721 ggatgcacgg tttttgacac aacaattttt ttctttttcg tgtggcctga agcaagcatt 2253781 gctgcttctg ccaaggctgt tccgccgtca tacatcgagg agttggcgat atccatgcct 2253841 gtcagttcac agatcatcgt ttggaattca aaaatagcct ggagctctcc ttgtgaaatc 2253901 tctggctgat aaggcgtata tgcggtataa aactcagagc gcgaaatgac atgatccaca 2253961 atgacaggct gatagtggtc atatacaccc gctcctaaga aagaagcgta ttgtacggta 2254021 tcacgatttt tagaggccag ctttgtcagt tctcttgtta attctgtctc tgatttcgct 2254081 tttttgattt gatgctcttt tttatatttg acgttttccg gtatatcagc aaataaatca 2254141 tcgatgctgc ttacgccgat agtagcaagc atctcctgtt tatccttttc tgttgcgggc 2254201 aaataacggt gcttcatgtg ttgtctcctc tctccaagaa aaaatattag cgtttataaa 2254261 atggtgtttt gacaaccttt gctttcacta attttttgcg tatctctaca tctacaacag 2254321 tcccgatctc actcgtttcc gaatcaatta aggcaaggcc gacgtttttt cctaatgtcg 2254381 gtgactgcgt gccggttgtc acctttccga cagacttgcc attttggaaa acctcatatc 2254441 cgtgccgcgg tatccctttt tcaatcattt cgagaccgac aagtttgcgc ttcgctccgt 2254501 tttctttttg ttcactcaat actgacttac cgaaaaagtc agactccttt ttgtgcttta 2254561 cagcaaagcc tatacctgct tcaatcggtg taatatcccg ggtcagctcc tgaccgtaga 2254621 gcgggagctt cgcttcaaac cggagtgtat cacgtgcacc gagaccgcat ggaatcaatc 2254681 cgtatgcatc ccctgcatcg atgatttttt tccaaatatg catagcatca tcactgcggc 2254741 agtaaatttc atacccgtct tctcccgtat agccagtgcg tgaaataagt gctttgcggc 2254801 cgctgatatc ggcttcatca ataaacgcaa acggctttaa tgcagacaca tccgcatctg 2254861 tcagattttt taagatcgct tctgctttcg gtccctgtac agccaagagc gcgatttgat 2254921 ctgactgatt gtcaatctgc acatcacctg ctgcatgttc tttcatccaa gccaagtctt 2254981 tatctatatt agaagcatta atgacaagca gatagcggtt ctctcctttt tgatagataa 2255041 gcaaatcatc gacggttccg ccatccgggt aacacatcgc tgtatattga gcacggcctg 2255101 gcgttaacgc ggaaacatca tttgtcatca atctttgcaa aaaagacaga ctgtcgttcc 2255161 ctgacacttc gacttctccc atatgagata catcaaacaa accggctgca gttcggacag 2255221 cctcgtgttc tttttttata gaagaaaatt gaacaggaag ctcccagcct ccgaaatcaa 2255281 tcgtttttcc tccatattcc ttatacaggt caaataacgg cgttcttttc agcatctaat 2255341 tcctcccctt tatcaacggc gcagctaaaa aacatacaaa aaaggacaga gaaacacctc 2255401 atgtaaaatg aaggttctct gtcctggcac ctgaaagttt actttgcata cgcaaagacg 2255461 tcccctttgg tggtttgcgc atccgcacaa acactctcca gagttgcgtc gagcaagagt 2255521 tcttttgcct gagagattca ctccgcagtt tgctccttcg gcgcctgtat cccgaggttt 2255581 tcggtcaggt ctctcccctt gctgtcattc gctcatattt tcatgctgtt atggacatac 2255641 tatagcaata tcttacatca aatacatact catatcctac catcatcact atatgctggg 2255701 caacagcaat ttgggcagat ttttcttata ttattcatct taagaatcga agaataagaa 2255761 aggcggtttc aaagcaatga atacagaaat gatctacgat gcaaaatggc ctgaagaatt 2255821 tgctgaaaga ctgaaaaacg atggcccttg ggcaaactgg gaactgtaca agctctctgc 2255881 agaaatccag aaaacattag caattccaga gtttgaaggc ttacgggctc ctttatatct 2255941 gccttccttt acgccgctcc cccaccagct tgaagtggcg caaaaagtgg ttgaaaaaat 2256001 gaacgggaaa gcgattttag cagatgaggt tggtctcgga aaaacggttg aagctggact 2256061 gattctaaaa gaatatatga ttcgcgggtt agcaaaaaaa attttgatcc ttgtgcccgc 2256121 ttcccttgtg tcacagtggg tcaaagagct tcaggaaaaa tttttgattc cggctgttga 2256181 acaaaagaaa agctatgtgt gggagcaatg cgatattgtc gtctcatcaa tagacaccgc 2256241 gaagcgctcg ccccatcgag aaatcgttct gtctatccca tatgatcttg tcattattga 2256301 tgaggcacac aaactgaaaa atagcaaaac gaagaactat gaatttgtcc ggaatctcgt 2256361 aaaaaaatat tgcctgcttc ttaccgcgac gccaatccag aaccgtatcg aagagatttt 2256421 caatttggtg tccttattaa aacccggcca tttaggcagt cagaatcact ttcaggagga 2256481 gttcgccaag aagaaatcca gtttagaagc gcatgaacat ttaaaagatc ttgtgaataa 2256541 agtcatgatc cgtaacaggc ggcatgatac agggctgaat tggaaacagc gccatgttga 2256601 aacagtgccg attcaatttt ctccatcaga gcaggcgctt tatgatgaaa tttctcgttt 2256661 gaaggacagt atcaataaac cagccagcat gttctcgatt atgaccttgc aaagagaatg 2256721 ctgttcgagc agagaagcgg tatatatgac gctgaaaaag atgcttgatc aaaaagagaa 2256781 acaagcacct gccattgatg aggatacgat ttcagttttg atagatcgca tcaatcaagt 2256841 gacacaaaac tctaaagcgc ttcaagttgt tgacttgatc aaaaagatcg acgataaggt 2256901 catcattttt acagaatacc gcgcaaccca gatttatctg cagtggtttc ttcagcaaaa 2256961 cggcatcagt tctgtgccgt ttagaggcgg atttaaacgt ggaaaaaaag actggatgaa 2257021 ggatcttttc cgcggaaaaa tccaagtcct tattgcaact gaagcaggcg gtgagggaat 2257081 taacctgcaa ttttgcaatc acatgatcaa ctatgacctg ccatggaacc cgatgcggct 2257141 tgagcaaaga atcggaagaa ttcacagact cgggcaggag cgtgacgtgc atatttataa 2257201 catggcgaca aaacatacgg tggaagagca tattctaaag cttttatatg aaaaaattca 2257261 tttgtttgaa aaagtggtcg gtgaacttga tgatatttta acgaaaattc aagtgaacaa 2257321 ttttgaagag caccttcatg acattttgta tcactcagca acagaagaag aaatgaaaat 2257381 aaaaatggat aacttaacct catttttgtc ttataaaaaa cagctgcctg ctgaaaaaag 2257441 aggatcttag cctgtaagga ggttttatta gtgagacagc aagaggttca cgattttctg 2257501 ctgcgttttt ttcaagcaaa cagctgccaa atcgtcgatc aaggcttagg ctatatgaca 2257561 gtgcagctta cagttgaaat ggacaaacaa atcatgaacc gccctttcta ctggcattgg 2257621 cgcgagaaga caggcggtga tccgaatcca atgaaaatca cttttattac agataaagaa 2257681 aatgcgccaa aagacctaga tggtgaattt atatattttg gggccccgcg tctttttcaa 2257741 atattcaaag ctgttaaaca aaatgggaga tttaccagaa tgtatgagaa aattgaatca 2257801 gccggagcta aagtcccact tcagccttgg cttggtataa atgtcacgat ttcataccag 2257861 tccgacatga aaaaggataa gttattgtca ctaggtcttc acctagtctc tggaacgata 2257921 attgaagatt ttcaaagcaa gctgacccag ttttcactga cgtctcaaat atgtgactat 2257981 tgcttcacca tttcacctat gatcaaacca gaaagcggac ttaagcgtat ggaaaactat 2258041 atttccaaat ccgctatgca ggagccgtcc gactgggcgg aacaggcggt taacaggtgg 2258101 aagaatgata tgacattgct tgataagttt tacgagcata tagaagaaaa accagaagaa 2258161 taccatctag aaaaacaggc gctgaaaacc ttgtatcaac caaagatatc agttgaaatt 2258221 gaaaatggcg gattgtttta tctgcaaaat aatatttcaa gctaactttt ttaccattcg 2258281 acatcattct cgtttttttt gagaaaatac gattataata aaggtatatt ggaaaaaaat 2258341 tctggtgatt taatggcaaa tgacttccag agactaatga agcatacaat aagtcatggc 2258401 cggactggct gaaatacata aacaagtatt ttaggaggag aaactgcatg aagaatgcaa 2258461 aacaagagca ctttgaattg gatcaagaat gggttgaatt aatggtggaa gccaaagagg 2258521 caaatatcag cccggaagaa atacgaaaat atttactttt aaacaaaaag tctgctcatc 2258581 ctggtccggc agccagaagt cataccgtaa atcctttctg aatgtgctat aatatcacaa 2258641 ggaaggtgat gacattgatt ggccagcgta ttaaacaata ccgtaaagaa aaaggctact 2258701 cactatcaga actagctgaa aaagctgggg tagcgaagtc ttatttaagc tcaatagaac 2258761 gaaatctaca aacgaacccc tccattcaat ttctcgaaaa agtctccgct gttctggacg 2258821 tctcggttca tactttgctc gatgagaaac atgaaaccga atacgatggt caattagata 2258881 gtgaatggga gaaattggtt cgcgatgcga tgacatccgg ggtatcgaaa aaacaatttc 2258941 gtgaattttt agattatcaa aaatggagaa aatcccaaaa agaggagtag tgcctgagca 2259001 gaggcactaa ctcctctttt gtcaataacc atcgagacgg cccagtatat gaatactggg 2259061 ccgtctcttt tttttgctgt tattaatttt tatcctcgct atgcgctttt tcattttctt 2259121 tcacgtaacc atctttatca gtatggtcct ttttgattgt caagccgttc cactgtgtag 2259181 cttcgaatga gaattgaagc ttaatggagt tgccttgata tttattttga accataagcc 2259241 ctttttcatc ttttgtttta tcatccttga attggatttc catttgaacc tgatcgaagt 2259301 cagttggtgt ttttggaaca ccatcatatt caggagcggt tttaccatca attgttgcta 2259361 cattgacttt accgcttgca tttaagaatt tagggtcaat ttgttttttg attttttcag 2259421 cagccgctgc atcattttta gcagacatca aatacaagtc tttaaggttc gcatcatcta 2259481 aaataatgtt tttcgggtag ccattgccgc cctcttttcc aactgtcaac aatgtcactt 2259541 caaactggct gaggaaatct tctggagatg tattgctgcc gccgtttgct ttaaaatctc 2259601 cataattaag cgccattaga acttctttga tcgcaagtga tccgttattt tcaaattgga 2259661 aatcctttgt caacttatct cccggcttta gatttgataa gttcacactc gctgaattct 2259721 ctttagcaga taaatcaagc gtacctgatg caaaagtagc atcctttgat ttaatgtcgt 2259781 taaatgctgc ccatgttcct cctccaacta aagctaatcc tagtgctgca gaagcaactc 2259841 ctaaactcaa tttctttttc atacccatgg taagctcccc ttttattgaa tgattttata 2259901 tcgaaacctg ttgccaggtt tacaactgaa gttaagtaga catggtgctg tcctttgtat 2259961 ctgtttccaa ggcttttgtc tttctttcaa tttctctaat ggcgctgctg atcgtcacaa 2260021 aagcgtaaac taacagcatc acgccgggaa caatcaataa tacagccgtt ccaatcggct 2260081 ggctggcaaa atgaagcata tagccggcat atggaagctg aaaacctgtg tattgcgcgc 2260141 gaacattttc gtccgataca ggcgctgaat cagctgctgc attattatca ccttttgttt 2260201 taaataacaa atggtctcct tgctttgtta tgtcaacaat tctgtgggtg accgccgtat 2260261 ttgcatcctg cataaatgta ataacgtcac ctttttggag ctctttcaca tcagtgattt 2260321 ctttgaccaa tattaaggaa cctgtattga actccggctc catcgaacct gacagaactg 2260381 atttcagcgt atacccaaac actgccggct ctcccccgga tgaacgtgtt gaaatcacga 2260441 caagtgtcag cacaataata agagtaaaga tgatcacgta taaaatatta ctgatcagct 2260501 tcattgcttt tttcatcctc ttccccgctt tccttctggt ctgattgagt ttctttttct 2260561 ttggttacag cttcttgaga tgtttcttct ttcattgttt tttccggtat atctttttgt 2260621 gttgtttcat tctccttttt gacgtccgac tttgtttctt ttttagggac tgtcggtttt 2260681 tcatcgcatt ttgcaagcct cataggctcc gaccactcaa atgtactgcc gtttgccggg 2260741 tagcctgccg gtttatatac tttaaatgca taaatgccgg gtttcatttt tttcttggtc 2260801 tcaattttat aaagtgaatc gccgatttga ttggagacaa atcctttttc gatcacgttc 2260861 ccatccttta acggtttgcg ggcattttca agcttatgaa gctcccactt ccactttgat 2260921 ttcttaagtt tctcacctgt attttcgagc acagcaaata aggcgaaagg tgagcataca 2260981 gtgcctttcg tatccgtttg atctgatatg tgcaaatcac tttgatccca gcgtttatca 2261041 taatggcagt ttttatctgt atgctgaaag tctttacacg tttgaagtga gacatcaaat 2261101 gtttcaatat catgaaaagc agcgcttgta tcatcggaaa attgtaagca tattgcggca 2261161 gtcagactga aaatgactga aagctgaaag ataagcagaa ctttcagttt cgtcttcgcc 2261221 ttttgctgat tgtgaaacaa tcgaaacata tcttacctcc tgtaaaacac tgtaacttga 2261281 tatgacaatc gttctcttta aagaacttca caaatagagt ataatcaacg atttatagat 2261341 ttaaaaacac cgaaatcgct cattttgttc gtttaaaaga atgttttcat catattacaa 2261401 agtcttgctc agtattgctc attttttcaa ttttttagaa atttttggga ttgttatgtg 2261461 agaatttaaa tgcatatccc attattattt ggtaataata aacaaagaaa gggtgacagc 2261521 atgatgatca aacaatgtgt gatttgtcta tctcttctcg tctttggcac cacagccgct 2261581 cacgcagaag aaacaccgct tgtaaccgcc cgccacatgt ccaaatggga agagattgct 2261641 gtaaaagaag caaaaaaaag gtacccgctc gcacaggtac tgttcaaaca aaaagtatgg 2261701 gaccgtaaaa gaaaagatga agcagtgaag caataccatt taactctgag ggaagggtca 2261761 aaagaattcg gcgtttttgt gacgatttca tttgatcctt atagccaaaa ggtcaataaa 2261821 attgccatat tagaagaata tcaataaggt cctccatttt ttgaaggacc ttattcgttt 2261881 atttgcggtt attttttccg tttcagccaa agtcggaagc catagggtaa aataccgaac 2261941 cactgctggg aaacaggcgt ttttgtttct ttccgcacct cttttcgttc ttttcgctca 2262001 tctctcggag tatctatata tttgacaaat tgctgcgtca tatatttaac ataatcattc 2262061 gttttcacgt gatcacctca tcattcaatt attatgagtg ttgtctcaca tgactttttt 2262121 tatacccttt acactgtttt attctgtcca tctcagcagt tttttctgtt tttggtcaaa 2262181 cacgatctgt gcagttcttt ctgttcccga atccgttgac actcttaagt tgatttcttt 2262241 ttgttctttt atcgatgtat catgaatgta ataagaaacc cgtccatata gaaattgctg 2262301 cgtaccctcc tggcctttcc gttcctctag aacatgccga atcgaaagaa gcaccccatt 2262361 ttgaagcaaa ttctctccta tgtataactc ttttgtttcc ttctcaaaca tgcagcgtga 2262421 aatatattga gcagcaacaa agttcacgat taacagcaca agcgctgaca caaaaagaac 2262481 agctggataa ataaaccctc ttgtacgata cattcacccc cctcctaaat acgaatagac 2262541 tggaaaagca gtttgataca ctttttggtc ttcactctca attttcagca aaacaacacc 2262601 attttcaata tcagctttca tggcagtaat atgatctaaa atcggaacat gccctttgcc 2262661 atccactctt tttcttatca ttgaatgata aatgtcaaaa cggatgtctt gtccggaaag 2262721 attggtgcag attaacacgc tcccatgctc ggctgtctta actgcctgtg attccttgca 2262781 ttcattcatc atctgttcta tcgaaatcat ccattcctgc tgtgtgaaac cgtcatgttc 2262841 ctgctgtcga gacaaaaaca gatggataat cgcagctaac gatcctgata tgagcaaaaa 2262901 gactgagagc gaaaataata cgttaagaag cgtgtagcca ttctgtctgc aaaatgctga 2262961 ggcaaaatga tttttcttta taagctgcgg ctttgataca tacgttttga tattcgccct 2263021 cctcctccca cttcattgca tagatatgat tgttctttgt aatcgttttt gacgcggctc 2263081 cttcaccact catgacatat ttgctaatgc tctcattcat catctgatag ccaatttctc 2263141 gtgattccgc cattttttca tcagccatca gcttgtccca caaggggacg actgtcagca 2263201 gcacaaacag ccacaggctt agcgcagaca ttgtttctat tgtagaaaaa cctttatttt 2263261 ctctccacat tgactctccc gctccctaga taaactgtta tgtcataaac ggcatggcct 2263321 tttactcgta tttttccgcc tgcattcggg tgccctttct cattaaattc caaacggtct 2263381 tttaatgtca gcagttctat agaaagtccc gttgcatacg gacgttcaat aaccgtatca 2263441 ccaatgacta attgatattc ttttttatga aagagaattt ttgttctttg ttgacgggaa 2263501 atagcagtct gctgtgtgag cataatatca tttttcagct gacttgctgc ctgtcggaca 2263561 gctgtattgt cataagcagg aggaagtgta gtgaagacgg ccaccaggag gatagaggca 2263621 aggcttaaca caagcaaact ttctaaaagg gtaaacccct tctcctcgtt taatttaatg 2263681 ttcaacctta acttctccgc cggtgatgat aatgcgctta ccatttggac agacagcatc 2263741 ctttttcaca tagccctctg actgtaaatc ggcaaggctc ggagtttgtc cttcatgatc 2263801 aagctcaaat gcagtcattt gtgccttaac catgttttgt aagccttcac agcccttttt 2263861 ttgaatggtt tgattatgtt tcgtgacgtt cggtatcgta attaaaagca aaatcgaaat 2263921 aataaagagc acgattaaca tttcaacaag tgtaaatcct ttctcattca tcagcctctt 2263981 cctttcacat ttgattcatc atctgataca taggcacaag catagataaa tacacaagta 2264041 agatcatcgc tgcaacaaat ccataaatca ttggctgaag gatgcctgtc catttttgcg 2264101 ctttgtgttc cagccgctgt aatatgaatt ggctgtatgt gaaaagctcc cgatccaatc 2264161 ggccgctcag ctggccgtga gatatgactt ttgataaatc agtttcataa aaaaggcttc 2264221 cacaaatagc ggattcaatt gactcaccgg cttttagccg ttcaatcaat tgttcagcct 2264281 cgcagcggta gaaagggaga aacgtttgat gtttaaatgc attaaggctg tcataaattg 2264341 agaggcctga ttttaaaagg ctgcttagct gcaaagaaaa aaagtagctg ttaaacagct 2264401 ttacaagctt tccaaccaaa ggaatcctga tacaaatcag catttgccgg gcaggtgatt 2264461 ttttcttaaa cacaagccaa taataaatcc cgatacctgc tgtaaaaaga acaagcaaaa 2264521 tgatcacaag atcaatatgc tgaaaaaaag caaaaagcat atcggttgaa cgtgaggttt 2264581 ccatattcat cgattgatag ataccggaaa actgaggaat gatgatggac tgtaacatat 2264641 aaaacatgac agcgaccgta aagatgagga aaagcggata gcgcagcact cttttcagct 2264701 ggtctgcctg tgcaattttt cgttccagca gctctccgct ctggatcatt gaagcaggca 2264761 gttcaccatg tgtttcagca aaataacaaa tacctacggc ttccttatga aatgacaaac 2264821 tctttagtac ttgataaaac ggagcccctt ccctcaaaca agtgaccgaa tcagtcaagt 2264881 cagccgcctg cctcttattc atctgaagtt ccatcaggcg taatccatcc agaagtgtat 2264941 atccgcccgc agtcatttca ccgagcctct ttaataacct ggcttgatcc tttaacaacc 2265001 agacttttct aatctttttc atgataaacc caccggtcat agttgtttgt cgttaaatag 2265061 ccgagcgcaa ttccttttct gataatttga cgaagcgttt gatattggta atttgcatga 2265121 tttccttttg cctcctggat acattgctga agatttttcc cgtatagaag ctcataaacg 2265181 ctagctctcc tagtatttcg tgactgtcgg caatacactg atgaacatcc gttttcacaa 2265241 aacgggcaag ccaaatcaac caagcgctga gccgctattg caatgacagt ctgttcgatt 2265301 tcattcatat tgataccgaa ttcaagcagt ctgtaaattg cgccctttgc gtctctcgta 2265361 tgaaggctcg ttagtaccag atgtcccgtc atcgctgccc gcaccgcaat ttcagctgtt 2265421 tccgcgtctc tgatctcacc taaaataatc atatcggggt catggcgcaa aattgctttc 2265481 agacctgcgg aataagttac accggctttt tcattcacct gaacctgaag aacatcttcg 2265541 tcccttgttt caacagggtc ctctaatgtg acaatatttc gattaaagtg tttttttgca 2265601 tattgaacga gagagtataa tgtggtagtc ttccctgaac cagtcggccc ggtaaaaatg 2265661 agcatgccat gggaatgttt taaaaacgag agtaatgtgg ctcctgtctt cggaaatagc 2265721 gacaatttat caatcgaagg gatattgtat tggggcatca ctctgatcac gaggctttct 2265781 tcattaattg tgggcagcgt tgacattctt aaatgaacat ttccctcttt caactttaac 2265841 gtaagcgaac cgttttgcgg ctttcgcctt tcacctatat ccattgctga aagaaattta 2265901 aaatgtgaaa tcagtcttac gcactcttct tttttcatgt cccttttttt cagcaaggca 2265961 tgatcgaccc gaaaatgaat gatagcgtcc cgctccctcg gcacaatgtg aatatcagaa 2266021 gcctttgtta gatatgcctc ttcaatcaag tttttgctta ccttttctat tgaatccaat 2266081 ttgattccct ctcctttcaa cgcatattgt agaaaaagaa gaaaaggtaa tcaaacaggg 2266141 aaaacgtgat tttgtgagat gttatatgct gaaaaaccaa ttctttctgg caagaaaaaa 2266201 gactttcaac tgaatgtacc cctgtcatta taattttccc tataaataaa aaagcagaca 2266261 tggtcaccat gcctgctaga ttccattttc attatgctgt tttcgcttat tgaccagtat 2266321 ctttctcaac ggaaagatcg cctaatgcaa caataccggt catttggtca ttttcaagaa 2266381 tcgataaact gcggatttaa tgctctgtca taagcccctt gacatcgtat ccggtcaccc 2266441 tgatatgtct ggtgaaaaag cggggcacgc tgcacaaaat atgaaacatc ctatagagtc 2266501 cgcctttttc gaggtttctt tttcttcttc cgctcctgca gcatatctcc cgtccagcct 2266561 ttttttctca aatagagata gatcagaact gtagatgtga caatcaataa gagggaaaag 2266621 agatatccgt atttccaatt cagttccggc atcactgaaa agttcatccc ccataaggca 2266681 cccagagctg taatcggagt aaaaagcgtc gtgaaaatgg tcagcgcttt tacaatttca 2266741 ttccccctat gtgaggtaat gacttcctct gaatgcagca gattgttaag ctccccttca 2266801 aattcgctga tgtatgtaaa tcccctgtca atcttcagtt gtgtccgctg ataatccttt 2266861 ttcccttcat tttgaggtaa aaaggtttct ttcaacgcca tttcaatttt tttagcgctt 2266921 aatatcaaat ttttccaaat catcagttca tggcgcagga gatggacgcg gtttaaaatg 2266981 cttttgctat tgtcgtcttt aatttgccat ctgagctttc tcagcttgac ttcaaattca 2267041 tcaacaccga ttaaatacgc attcattagt tcgccgagaa gaattaaaaa cccctctatc 2267101 gcattgtccg ctctttccat ttgccgaaca acttctttgc ctttaatctc tctcaaaatt 2267161 gaaaagtcaa agttgattgt aaaaaaatat tgtctggtga tataaaagtg aaaaacagta 2267221 tggtcttttt cttcaccaag cccctgatca taaacaatcg acccaaatac tgcttcattt 2267281 tccgtttcag ttgtatctac tcgcaaaaaa ttaacgtgat ggttattttc aaaccacttt 2267341 tcacactgag gccagtgaga aaaatggatt agatctcttg ccttacttct ttcttgaggc 2267401 cccatttggt accaaaacca atcctttccc gtatgtgcct tcatgtcaag ctcctccaaa 2267461 cttttgttct ttattcttta attgcccaat aaccgcgtca ctaaaccagt ctgccgcttc 2267521 aacacatgtt ttatgagcat tttcaggtgg tatggaatgt agaaagacat cggaaaaggg 2267581 aggtgcatgc cttccttgga gaaggcagtt gttttggaat ttatcaattt actagcagtc 2267641 gctattctca ttttgttaac aggatttttc gttgccgtag aattttcaat cgtaaaagtg 2267701 cggcgatcca aaattgatca gcttgtcgca aaaggaaaga aaggtgctaa agcggcaaag 2267761 catgtcatca ctcaccttga tgaatattta tcagcctgtc agctgggcat cacagtcgca 2267821 gctttaggac tgggatggct tggggaaccg actgtgcaaa ctctgcttcg accgcttttt 2267881 cataaagcag gcttaaatga atcgcttacc cacctgcttt cactcgtcat cgcattttta 2267941 gtggttacgt atttaaatgt cgttattggg gagctggcgc caaagagttt cgccattcaa 2268001 aaagcagaaa gcattacctt gttgttcgct aaaccgctta tttggtttta taagatcatg 2268061 tttccattca tttggctgtt gaaccactct gcccgattga ttacaggagt gtttgggctg 2268121 aagccggcat cagagcatga gctggcttat acagaggaag aacttcgggt cctattggct 2268181 gaaagctata aaagcggcga gatcagaaaa agtgaattaa agtacatgaa taatatcttc 2268241 acctttgata aacgaatggc aaaggaaatt atggtgccgc gaaatgaaat ggttagtttg 2268301 tcactagatg aagactccat ttcaaatctt caggaaacag tcaagcaaac aaaatataca 2268361 cggtacccgg ttgtaagaga ggataaagat aacgtcattg gcgtgattaa tatgaaagaa 2268421 gtgctgtttt ccatgctgac gaaagatttt tcaatcaaga agcatcaaat tgaacctttc 2268481 gtacagcccg ttatccatgt aattgagacg attcctattt ataaactatt gctgaaaatg 2268541 caaaaggaac gcactcatat ggcgatcctc atagatgaat atggcgggac gtccggtttg 2268601 gtcactgtcg aggatattat cgaagaaatt gtaggagaaa tccgtgatga atttgatgcg 2268661 gatgaagtgc ctcatatccg cgaacttgga aaggatcatt acttgttaaa tgcaaaatta 2268721 ttaatcagcg atgttaacag cctgcttgga accgatttat cagaggctga agtagacacc 2268781 ttgggcggct ggtttttgac acaaaacata gacgctgagc ctgaaagtgc catagaatat 2268841 gatggctact cttttaaggt aaaagacatc aacagccatc acattttatt tatagaagtt 2268901 aaaaaagctg aatagcccgt gaaaggctgt tcagctgcta tctttcaaga taaacatggc 2268961 aaaggcatca acactctttt attttaaacc ctttattggc cagggcttta gcaagacttt 2269021 gctctgtttt cacattcgaa aaatccagac ccagcttcac gacagtttgg gcaatttccg 2269081 gcctgattcc tgaaataata gtctcaatgc cgagcaattt ggtgctgtca atcactttaa 2269141 aaatttgata ggctaccatg gtatcaacga taggaacgcc cgaaatatct aaaaataaat 2269201 acgagagctt taacgctgag cactgctcca gcacagactc caaaatcgtc ctcgctctgt 2269261 gcgtatcaat ttcaccgaca agcggaagaa tcccaattcc atcagtaatc ggcataatcg 2269321 gcgcactcaa ttcattaatc atttcttttt gcgcgtttaa ttgtatcatg gtcacctggt 2269381 gatattcttc cgtaaacact tcgatgatct catcaatgtt ttgattcaag atccggctcc 2269441 actcataaaa ttcctgaatg ctgatgtctt gagaagaagc ttcgctgaat ttatgaatcc 2269501 attcaaacat gatgtgcctg aaagtgttaa actggccgac actttgtgta accgtcactt 2269561 catgaacggc acggtctctg gcgcattgaa gagaccaccg gttgagctca tcctctacgt 2269621 cttcttttct aagggatttt gctacgatgg tcaccaataa ttcatgctgg tcttttaact 2269681 tttgttctag tttttgctga tctttcgctg aatacagcca gctgccgttt gacgtacaaa 2269741 cttccagcca ttgttgcgta atatcttttt tgtgctctgt taagtgctga tcaagagcta 2269801 tcatcttaat gagttacctc ctgtttttga aaaatgtacg ctatatatgt ataacgcgtc 2269861 tgcctttaca catactatgt ttagattcaa tgggctatag ccaagcggta aggcaatgga 2269921 ctttgactcc gtgatcgttg gttcgaatcc agctagccca gtttctgaac aggtgaaaaa 2269981 ccgaagataa gctgattcgt ataaatcagc ggatcttcgg tttttcatca tgcagattga 2270041 tgaaccgttt tcttcttcga taacttcaac agttctcccg ggttataacc aatcaccagc 2270101 tttttgttgt ctactagaat cgggcgtcgc aaaagcttcg gcttctcgat taaaagttcc 2270161 agcacctcat ttaccgtcat ttcttcaatg tttaaattta aatttttgaa agtctggctt 2270221 cttgtcgcca aaatttcatc aattccttct gtcgttaacg ataaaatgta ctttaattct 2270281 tctcttgtcg gggtttctct gaataagtgc cgttcgttaa attcaatttg atgtgcttta 2270341 agccaatgtt ttgtttttcg gcatgacgtg cagcttggat atgagtaaaa agttaattgt 2270401 tgttccattc gttttttcct cctcagttaa ccatctcttt gtagaataac tacccggatc 2270461 atttttcatt taaaccattt acagaacttt tttcggatta ttttttaaaa aacattcata 2270521 caatagaaaa cacaatcaaa gggacaaatt ccatttgtat attaataatg aaaatgttta 2270581 catttctagg tgtgatctat tataataaca gtcagaggga ctctcgggag gggataaaaa 2270641 tgaatcgcat gttccgggtg ttaggatttt ggacgggaat ttttgcagtc atgttttatt 2270701 taggtgatat gaaagatgct tcccttttat tttttggaca gacgatctta tttgtgtttc 2270761 tatcgtattt gaacttaacc gaacgcatgt atatttatat ttttggcgct tatttaacaa 2270821 ttttcttcgc cggctttaca tattactcaa tttttattat ggtgcccggc ggcggaggcc 2270881 attaaatgca gaaagagaca aaccttatcg gtttgtctct ttttttacaa tgaaaaccca 2270941 tttaaaaacg gattttgatc ctgctcagtc agtacgtctg tttcaggtcc atggccgctt 2271001 aacaccagcg tgtgttccgg aagcgtaagc agtttttcat gaatggacgt cagcagcgtc 2271061 tcttgattgc cgcctattaa atccgtacgt cctataccgc cttggaacaa gacatctccg 2271121 gaaatgacca agtctgcatc tttcacgtag taagacacac tgcctggtga atgtcccggc 2271181 gtaaataatg tttccaaatg aaacggcccg atattcaact caccgtcgcc ttcaattaga 2271241 tgatctgcag gcttagctgt gacttctatc cctcgcagca tgccggagcc gtttaaagaa 2271301 gcgtccgcaa gccaattttt ttcattttga tgcaggtaaa cagggatatc ccatttttct 2271361 ctcacttcat caagcgcccc aatatggtca aaatgggcat gtgtaagcaa aatggctaaa 2271421 ggcgtcagcc ctttttcttt tatgtattga ttgattttat gtccctcgcc gcccggatca 2271481 aaaatcagac attgatcatc actgatgaga aaatatgcgt tcgcttgaat cggccctact 2271541 ggcattcgtc tccatttcac tattatcacc tctttctttt ttatgctctt attatgaggg 2271601 tttttgaaaa aagattcaaa caatcgcaat gaaaacgcta tcgacaaacc tataaaaaac 2271661 aggtagaata aaactggaaa gaattgcagg tttttcaatg taaagggggc tgtgttatgt 2271721 tacttgtcgt gattttcggc cttgtcgctc ttttcgcttt atggggagtc ttgcgttctg 2271781 ttagaaataa aaatatactc gggtttttat tagccggtgc caccttattt gtctttggat 2271841 ggtttaccgt gatgaccgta ataaacagcg ggtatccaac cgcacattaa aacctgtatc 2271901 cgatcggata caggtttatt tttatggctg taaatgttta ttgacacttt ctattttgct 2271961 ctcaagcgtc gtttttttgt cacgcctgtc atcgatacgg atattcgttg ccactctgtg 2272021 caatcctttt tgaaatggcg cttcgtgaat tgcctgaata actgcaaaaa ggtcactgag 2272081 ttctccctcg atcagcgtat tcatcggtgt cagctgatat ttgattttcc cttctgcttg 2272141 atatccttct aatatctttt gcacatcggc tacgtaagca ctgacactgg gtgtttccgt 2272201 accgattggg ataatggtta catctgcgat agccatcgtt attccatctc cttttgatca 2272261 atgatgagtt gcttcgtttc atgtgatttc aataaaataa tttgctcaaa atgaaagccg 2272321 tataacgcat atttcccgtt cggagatatt tgaatcggct ccatttcccg cagagacaca 2272381 agatcttttg tctctcccga tgctacattg attgctgcga gcttatatgc atcgccgctt 2272441 tgtttgaatg tataaaacag gcctcctgct tcatcatagt catactccat tggagccaaa 2272501 cttgtatatt tcgcttggag cggccatttc gctgtaacag gtgatgttga ttgcggcgtt 2272561 ttaaactgat acgtcccttt tcctccggaa gctgatttga cagtaaaact catttgatgg 2272621 aaagaatcga agaatagaac gttatcctca agcttctgtt ccgtcttaga agctgtatcg 2272681 aacgtatata aaggccctgt tttatcgtct ctaccctctt ttacataatc aaatgtattt 2272741 ttggatgtcc aatgaatgaa cggaacctgt actgggctta agaaagattc gtctttttta 2272801 gcattcacct gatatgtatg gaaatcccag ttttcattga attccgtcac catcatttga 2272861 taaggatcat actgattcca agcagcttca agctcatacg tttcgtaatc tttttcgtaa 2272921 agcgtctctc cttctgcatt aagcaaaacc actgccgtct tttggctatg tgtgatttgc 2272981 agcagaatca tctgctccct cgcattgatt tgaacatcaa cgatttgacc atccgtttga 2273041 tagagctttt tcgctttgcc tgtaaagatg cggtacgcaa aaagctctgt tttcgtcgga 2273101 ttagacgcag tatataatat tgtgctgtta ttcagccagc cttccgcccc atccgctttt 2273161 tccgcggaaa gcggtatgat gtcttttttc tcatcttttg ccgccgatgc ctgtttttgc 2273221 tgctgatgag atggttcgca tgccgataaa ctaaacagca ataccgccag cagaataaaa 2273281 caaactgatc tcatcagcat tcccctccga tcatctttat tctctcatat ttgcttcggc 2273341 agaaaaaaga aaaagtttca gttactcatg aaaaaataac gccctccaca agataccgct 2273401 tgtggcgtta tatatgtgtg aaaactgctg aaacggcaaa ggattttggc cttttccaag 2273461 ttccaccgta tacccttcct taaaataatg gtgaataaac caatcacgaa atccagcata 2273521 gctgtctata tcccttactc ccttataaat gttcccgctt aactcctcaa actcctttat 2273581 gacggcagca gattcctcag gctcaaggcc tttatagccc caataaattt cttctccttg 2273641 agtatgaaga gccagcagtc tgtcaggcgg attctccgtg atcagccggt acatcgcaat 2273701 agattccggc tccgtaagcg gagagattcc cggaaaatcg cggtagctgg gtgctgtcgg 2273761 ttttcggtat ttttcaattt cccataatga tggaaattgt ttatttaaat caaccccgtt 2273821 tatattcgcc ttccattcat taaaatttgg acgatgttca tttagccttt cgagttcatc 2273881 tcttctggct cccatgactt ctgatccgtt taaaacaaga tcaacgccat ccggattgac 2273941 aagaggaacg agggataagg atgtgctgtt aaacagcttt atgggagaaa agccaaagaa 2274001 aggcgaattg cagcataatg acatacagta ttccttaaac cattttagca ggacagacgt 2274061 tgtaatccac tcattcgcat gaaatgacgc gttcatatgg acctttttta cggcatgctc 2274121 cccaccagcc ttcagctccc agataggcct gccgagtaca gaacggccaa tttcccggca 2274181 tgagacaaac ggaaaaacat caataatctt ctttatttcc ttttcaacag ctgaatcatc 2274241 atagattttc tcttgctcaa tccagctatc tgaaagtttc agctgccgag gctgtaaaaa 2274301 gcgctttatg tcctgaatgg tttgaagctc tttgccgcta tgctcctcta tcacataacc 2274361 agggcaatac aattgatgtt tttgtgcgga gcgatttgca cttttaagca attcctcgtc 2274421 tatcttcagt tctttcgcca cattggccaa attgttcttg atctcaggtt tcaccgtaat 2274481 aaacgccatc atcatccccc ttttttgtta ctatatgaca gcgtatttaa aaaaagaaag 2274541 cctcccgctc acttcgatgc gggagacatt gtgattatga tgcctgatca agcatttgtt 2274601 tttctttccg ctttgacgaa ttgtccagcc ttttctggtc ataaaatcgc aacaaatccc 2274661 cataaatgat ttcatcagaa agtgatagct cctgttttgc tttatcagca aatgcttcac 2274721 attgttttgt ctcttctaac ggttttcccg tctctttgtc ataacacgca ccgtctgtat 2274781 aaacaacctg atctgtgata aagctcccgt cccggagcac cgtgaagtcc agtttttcgt 2274841 ctgaaagcag atcgttgccg aattgaattt gatctttcgt atcaatccct aaaagattca 2274901 tcagcgtcgg cctgatatca atctgcccgc ctactgtttc aatggtttgc ggctttttat 2274961 cagtaatacc cggaatatga atgaccagcg gcactttttg gagctgtacc tcttcaaatg 2275021 gggttatttc ttttcctaaa aactgcccca tcgcttcatt atggttttct gatataccat 2275081 aatggtcacc atataataca ataacagagt tgtcgtataa cccgtcttcc ttcagctttt 2275141 cgataaaccg tttcagcgcc tcatcctgat aacgcactgt cggaaaatat ttatttagcg 2275201 tctggctgtt tgaatcatat tcatcaatca attgatcctc ttcatcaaga tcaaacggga 2275261 agtggttcgt cagtgtaatc agcctcgagt aaaacggctg aggcagattt ttcatcagct 2275321 ctgaggactg ctcaaaaaat tctttatcct taagtcccca gccgactgaa ttttcgtcag 2275381 ttacatcata cgagttaata tcaaaaaacg aatcatatcc aaatgagtcg tacattaaat 2275441 cacgattcca aaagctctta ttattagcgt ggagcaccgc tgaatagtat ccgctgtttt 2275501 tcaaaatttc aggagcggcc atatattgat tgcccgcatt cgtaaaaaat acggcacctc 2275561 gtccaagcgg atacagtgaa ttgtccacga taaattcaga atccgaggtt ttcccctggc 2275621 ctgtttggtg gtaaacatta ttaaagttgt agctctgttt tataaagtca ttcagaaaag 2275681 gcgtgatttc ttctccattc aatttttcat taatcacgaa gctttgcgtc gactctaagg 2275741 atacgagaat gacgttcctt ccttttgcag cgccgaataa gcgtttgttg gcatccttcg 2275801 cattagcggt tacgtagttt tcaatctccg tcaggctgtt gctgtctgcc aacgctctct 2275861 gtgcggattg ctttgactga agaacgccat cgtaaatatg aaaattaaac aggctaatgt 2275921 ttttaacaag catttctctg tcaaatgagc gtgtcaatag ctgaggtctt tccgcctcag 2275981 acaagcccag gttgaagaaa taaacagaag caacgaacaa aaaataagcc gcccgttcat 2276041 ttttcgttga gggaatgtcc gattgaaaag ctttttgccg gatgtgaagc catattaaaa 2276101 ccgcaatatc tacagctaat aggaggtctg tcggctcaag aagtgttccg atgctgcttc 2276161 cgagatcacc catattgctc gtttgaaaaa gaacagggat tgttaagaaa tcattgtaaa 2276221 aacggtaaaa aaccatattt gccagcaata caaacgtgac aagacagctc atcgcgataa 2276281 tgtagcgatt tctgtttttg ccttttaaaa acaggctgag gccaaaaata agcaacaaaa 2276341 aactcaatgg gttgataaac agaataaatt cctgtgttag attgtcgatt ttaatatgaa 2276401 aactggtttt gtaaacagca tacgttttca gccacatcaa taaaatggca atcagcataa 2276461 atgaaatctt cgaaaaaaac gtttttcgca tttcaacctc ctatgcagca cgctcaaaaa 2276521 aatcagtcta ttcccaacat tctcattaac acatcaaatt aaatcttaac ctgagcacaa 2276581 caaaaaatca atttcattta cacaatttta acaattttga tgtttcagcc attcattttt 2276641 agcgatccaa gcgcctccga taacgccggc atcatttcca agtgctgcga ttgaaatatc 2276701 agcagcttgg gctgcccgcg gaaacgcgca tttgcggaat gttttctcga cttttgatct 2276761 cagcagttct ccggctctcg atacgccgcc gccaagaacg attttggatg gattaagcga 2276821 gcttgccaaa tttccgagca ccaaaccaag atgcttggct acataatcaa ccacctcaag 2276881 ggcaatttca tcattttcac ccgccgcttc aaacacatct cgcgctgaca attgttcggt 2276941 tgcttttaaa cgtgtcgtct ttttagcatt tgctattttt tcttttgcaa ttcttacaat 2277001 tccggttgct gacgcaattg tttcgataca gcccgttttg ccgcagttgc agggcgctcc 2277061 gccttcaggg atgctgcaaa tatggccgat ttctccgccg gcgccattta taccatgtac 2277121 aatttcacca tttgcaatga tgccgccgcc aactcctgtg ccaagcgtca cgagaatgac 2277181 gtcttttgcg ccatcacccg ctcccttcca catttccccg agcgcagcaa tattcgcgtc 2277241 attttctata acagctggga tgccggtttc tgtctccaga tggtttttca aagcataatt 2277301 tttccaccct agatttactg tttcataaac cactcctgcc gccatatcta cagggcctgg 2277361 tgcacccatt ccgatgtatt tgatgatgtg cttcggtttt tgcagctcat ccagcttgct 2277421 gtcgattgtt tttgcaattg tgacagtaat cgtgtcgccg gttttatctg tcggaacttc 2277481 ccacttatgc tgaatttcgc catattgatt aataaaagcg agtttaatcg tcgttcctcc 2277541 caggtcaatg cccgcaaacc atatctcgtc catttttatc accttagcct ttataaaaat 2277601 ctcttccgtt ttttgtttgt tccaattctt ttcgaaggac agctgccgct ctggcccact 2277661 gctccttttc aatcatgtgg ttcatgtata attcctttaa ttcatccagc ataaactcaa 2277721 tttcaagctc tctgtctcca aaataaacaa tgtggccaaa cgtttttaac agctgctgca 2277781 catcataaaa tgtattcatt ttcctcacca tttcttgaac ttaactatca taagcgtatt 2277841 cataaggaag cggtcagtca agaagaaaac gctgacaaaa aagccagctt cctttccata 2277901 ttccacctct atgattcttt attgttttca atttgccgct gcagctcctt gtagcgctgc 2277961 tccttcggct tcagtttcac agccgtctgg atggcctttt ctgcttgtgc aagctcattt 2278021 ttttccgcat acaataacgc taaattgtaa taggaagcat ggtctttagg ttcttttttc 2278081 actgctcgtt ccaaaaggga aaccgcctga tcatattcgc cgatttgaat atcagaaaca 2278141 gcaagaattt tcaaaagatc ggcagaggca tctttttgcg ctgcttctcc gttcagcaat 2278201 tctgttactt cttcatactt tccttcctga tacagctcgc ttgcctgctg aatcagcgct 2278261 gactcctggt gtgaaggcga atgcaatccg taatataaaa atccaacagc caaagcaatc 2278321 agcaaaaccg ctgacaacaa tctttttcca aaggctccgg ctttaggcaa ccccagtgct 2278381 gctgcagcga aaaagccgcc aatcaagccg ccgatatgtc ctgaattatc aatattcgaa 2278441 accgcaaaac caaagcccag attgatgata ataatgacaa taatattggt tcctatagtt 2278501 cttaaaaaca tttttcgatt agacaaagca acatacagta atgcacctaa gcatccgaat 2278561 atggctcctg atgcccctgc cgaaggatac gggctgaaca caaaactcgc aatcgaaccc 2278621 gtaatgccag cagccagata aatcagcaaa aatctccccg atccatacat ccgctcaacc 2278681 gctgtaccaa ccgaccataa agccagcgta ttaaaagcta aatgcgctat gccgatgtga 2278741 agcacgatcg gtgtcagaag ccgccaccat tctccttgtg caatcaggct gttttctttt 2278801 gctccaaaag ccaccagtgt ctccgtatta gtgctgcctc cgtttatttc gagcaagaaa 2278861 aacatcagga tctgaagcgc aataaataaa tatgtaaaag tcggttttcc gttttgaaaa 2278921 accgccgctt cagtttttct ctgttcttct tgtttcagca ctagcgaaag gaagcgttct 2278981 cgcgccattt gcgcgttttc aaacgaagcg tgttcctctg aacaatcttc tgtacgaaat 2279041 gatggaaaaa ccgcttgaag atcatctcga agcatcgttc ctctaacgat cgccggctca 2279101 actgacacag ttcccttctc aaaagttttt tttgcaatct cttcccagtc atcaactggg 2279161 gcttccgttg aaaaaaacac gttcagcagc ttcatccttc gtctgcccaa ttgatgtctg 2279221 actcgttcta ctcgttcggc ctgctcttcg atgtctctaa ccatttcttg acggaaatca 2279281 agatcgtgct tataaagacg aactagatca tgagaggact tgtccggcgc ttccagccat 2279341 atttcatctg actcaccggc ttgtatgacg ccatacccgc tattcaccag gtgcgccgca 2279401 attttccaat atgtatactc cagcaaaaac atgtttaccg ctccaatagt tttttttcat 2279461 tataacagct ggcgctccga aacgcctact gaaagcaaaa aatcccgttt ttcacgggat 2279521 tttagaaagc ttgctgtata aacttattgc ggataaatgg aattcttaaa aacaaatgga 2279581 taaaagaccg cctgattcct ggctggctga gtacagtatt cataagacgg tagcgatttt 2279641 gataaaacat gacggcagaa accgcgaaaa tggcatatat caaaagtttt ttcatgatat 2279701 ccctcctgcc aatagggttt gttattctac cttatttatt ctcgaataag ggacaggaaa 2279761 gttatgaaaa acaagaaata atccgatcct ctgttatcag cttatgtacc gggatgtcat 2279821 gcggcagacg gggtacgtgc gcaaacaact ggcactccaa aagcaaagag actgtcttcc 2279881 cttcatattc acttaaatag cgatcataat agccgcctcc aaagccgacc ctaaacccgt 2279941 taacatcaaa acaaacaccc ggaacgatca tcaagtcaat ttgtgatggg tttacttctt 2280001 ttgttttttc aattaccggc tcgagcagtc cggcgtacac ggtttcgagc tgatcatcag 2280061 tctgatatgt gcgaaattgc attttcttcg tgtccggatg gcattttggg atgcaaactt 2280121 gtttcccttc ttcccaagcc tgctcaatga caggacgcgt cggtatctct aatcctctgg 2280181 aaatagtgac ggcaatggtg ccggcatttt gccactccgg cagagaaaac aagtacttat 2280241 acatacgttc cgttttttga agaatatctt catttgataa agcagacagt gcctccagcg 2280301 tcttttttct taattgtgat ttcatctctc atccccctcg gaatagaaaa aaagccagaa 2280361 cctttttcaa agctctggct tttttcttac acctcaaaca gcaaagctgt tattttgttt 2280421 cacggtgtaa cgtagatttt ttatcacgtg ggcaatattt tttaaattca acgcggtctg 2280481 gattgttgcg tttgttcttt ttagaaatat agttacgctc accacattca gtgcaagcca 2280541 aagtaatatt aacgcgcatt attttccctc caaactaaaa tcatttactt attcagactt 2280601 atatataata ccactataat ggacggaatg ctaggctgtt tttcaatgaa ttgctgaatt 2280661 attgaagata cgctcataaa gctgcaaata tgatgacata atgagtcggg ggtggtggag 2280721 cttgaacact tgttgtctgc cagcttcttt tatccggcgg gctttttccc ggtcttttaa 2280781 aaaactgtcc agcagatcag cagcttcctg tacgagcgta aaatcagcga tgattgccgt 2280841 tttgtcatga accgcataat cacaaaaacc acctgactga gaaacgacag tcagcacacc 2280901 ttgttccatg ctttcttgcg cggcaagccc aaacggttca taagaactag ggaaaacagc 2280961 catttcacag tgagacagta acgttctgat atctttccta tttagaaacg gcagaaacat 2281021 gacgcgatcc ttcaggttat atgccgcagc caatttctca tagcaggaca gagacggccc 2281081 ctccccagcc agcactagat agaggtcagg ctgacgctgc ttcaagatgg caaacacctt 2281141 taacagctgc gataatcctt tttccggaac aaaccttcca tatgaaaaga ggaatcttct 2281201 attcatgctt ctcgggattt tccccttctc ttcctccata gatgcagggc ttgggataac 2281261 ggttattttc ttatgtgccg ccttatcaag agaccgcttc ataaatgtgc ttaatacgat 2281321 caatgcatca gcggattcta taaggagccg ttcggtcatg agcctgtatg ggtgtggggc 2281381 ttctcggcac accttcttcc tttcgctttc aagaccgtgg attgtcgcag caagcggaag 2281441 gccaagccgt tgtttcaaat actgggcggc aggggcagtt gtgtcatcat gggcatgaat 2281501 cagatcaaag cgtttattgt gtgataacac atggcgaacc attgtaaagt tagcatcagc 2281561 tatgtaatct tcaaacttcg catacgaaaa cagctgcccg ctcggagtaa aaaccgtaat 2281621 gttgatatga gggtttaaat aggaaatgag gcggtttaaa tggacaccga gcccgctttt 2281681 cggctcatcg ggatgttcgg gtgaaagcat gagaatgttc accgttcttt ttcccctctc 2281741 ccataacagg tgtatgcaga aaattgcgcc tcccacctgg tgtgcgcttc ttcaatctga 2281801 aaactgttta tatgacgaat cccattttca tcaagataga tgtcgtctgt accggcaagc 2281861 ttgagagaga cattcattga attcacaatt ctgtattcag cccgatatac agcatcacca 2281921 gccgcctgtc taatcgtcca ttctccttta tcatacgttg tgcgttttgt cctgacagct 2281981 tcaatgtctt ttcttttgat gacaatgcgc aattctttta tcatatcctg cgttttttcg 2282041 aaaaggaccg cttcagccag ccgcattgtt tcttctgaga tttcccagct tacggtcaag 2282101 gtgtgagcgt tttgaatgat tatgtcgaat gtgtccctaa aaaaggaaag cttatgtcgt 2282161 atattatagg gaaatgggtg tttatccatg gactcctaac attctccttt ccaatcgttc 2282221 acttcgtgtt cctattaaac cattacatga agaagaagcg aagaaagatt tctcgacaaa 2282281 atctcgtttt tttcgcgaat tcctttagaa actattggtt ttatggtata aaaaagaagg 2282341 ataaaaaaag aatagaaggt gatgaaacgt ggaaattgct attattgcgt tgtttatcgt 2282401 cagtatagcg ctaattgcat tctcatattc tcaaagagac ccgatgaaag atgtagaaca 2282461 ggagctcgaa acactgcagc tttctgcgat gcaggaaatt tacaagctca aaaagaaaat 2282521 gacagtgctt gaggaagaat tactggaaac aaaccttgtc attcgcaaat caaagcagaa 2282581 cgacatcaat caaaaaatcg ctaaacaaat actttctaaa tataataacg gtatgtcagc 2282641 tgaagcgatt gctaaagctg aacatgtatc agtggaagac gtgaatacga ttatcaaaga 2282701 taatgagaag gtgctcgtat gacaaaacgg ggcattcagg catttgctgg cggcatcatt 2282761 ttagcgacag ccgttcttgc agctgttttt tatctgactg acgaagacca ggccgctgct 2282821 gtaaaagata ataaaacagt aaccgaacaa gacgtgaaca attatcttga ttctaaaaaa 2282881 ttggtttctg tcaaccgtga tgaatatcaa aaacttctcg attcaaaaga gaaatcctta 2282941 aacaatgaca gcggctcaga cacgaaatca gacaaagtca aaacctacaa gctcaccatt 2283001 aaagacggca tgagcacggc ggatgtatct gctattcttg aaaaagaggg cattatctct 2283061 tcggctcaag actttaatga ctatgtcatt gatgccggct atcacaaaga aattcgtgcc 2283121 ggcgagttta aagtaaaatc agacatgagt ttcaaaaaga tcgtaaaaac gttaacacga 2283181 taaaaaaaca ggctgactca gcctgttttt ttcatccaaa ctttcctgaa atgtaatcga 2283241 gcgttctttg gtccttcggg ttagagaaca ttttattcgt attgtcgcat tcaacaagct 2283301 cgcccatgta gaaaaaggcg gtttgatcag aaacccttgc tgcctgctgc atgttatgcg 2283361 tgacaatgac aattgtatat ttatctttca gctctagaat gagttcttca atttttctcg 2283421 ttgagattgg atctagtgca gatgtcggtt catccatcag caaaatatca ggattggtcg 2283481 caagtgctct ggcgatgcaa agacgctgct gctggccccc tgacagcgaa agagcggacg 2283541 tatgcaatcg atccttcacc tcatcccata acgccacgtc ttttaatgac ttttccacaa 2283601 tttcctgaag cttcttctta tttttggtgc cgtggactct cggtccgtaa gccacattat 2283661 caaaaataga ttgcggaaac ggattccctt tttggaatac catgccgata ttttttcgca 2283721 aatccacgat gtccacttta tcctttaaaa tgttgctgcc attatagttc agctcacctg 2283781 caagctttac attcggcgtc atttgaatca ttaaattcaa tgtcttgata aaggtcgatt 2283841 tcccgcatcc ggatggtccg ataatcgccg taacctcatt ttcataaatg ctcaaattga 2283901 tattttttaa agcatgatgc tgcccatacc ataagttcat tccattgact tgatatactt 2283961 cctgtttcat tacagcttcg gtagcaatac tcattgccgc cctcctatcc gaatttcccg 2284021 ttaatataat cctctgtctt ttgctttttc ggactcgtga aaatctgttc ggtctgtccg 2284081 tattctacaa gctcgccgtt taaaaagaat gccgtccggt cagaaacccg cagagcctgc 2284141 tgcatattgt gcgtgacaat aataattgag tattctcttt tcaatcctgt aattaattcc 2284201 tctatttttg catttgaaat cggatcaagc gctgaagctg gttcatcaag cagaagaaca 2284261 gccggcttca tcgcaagcgt tctcgcgatg cataaacgct gctgctggcc gccggataac 2284321 gagagtgcgg atgaatgtaa acgatccttc acctcatccc agagcgctgc ttttgttaaa 2284381 ctttcttcca caatttcatc taaaacagct ttattccgct ctccggcata tttcaatgca 2284441 tgtgtgatat tcgcatagat cgatttcgga aatggatttg gtttttggaa aaccattccg 2284501 atttctcttc tcaagctgac aacgttaata ttgccgccca atatatttaa tccctcataa 2284561 aggatttcac cttccgctct tgcagatgga attaaatcgt tcattcggtt aatatttctc 2284621 aaaaaagtag attttccgca tcccgacggc ccaattaaag cagtcaccgc atttttttca 2284681 atatccatgt ttacatgatg aacggcttgt ttatttccgt aataaatgga cagatctttg 2284741 acctcaagca cgtggttctg cttcggaaca ataacagctc gctcaggttt ttcttttacc 2284801 atttgttcag acatgttttt cgcctctttc cgttctaatt tgccgtaagc tttttgtaga 2284861 tcatcgtgcc aagccatctc gccgcgagat taaacacaag aacagaaatc accagcacgg 2284921 cagaaccacc gttggcaatc gcttcagcat ccggaatcat tccttgtgta ttgacgttcc 2284981 aaatgtggac cgcaagtgtt tcagcgggcc tgaaaatatt aagcggtgat gtttccgaaa 2285041 acgggttcca ctccgtaaaa ttaagacgcg gtgttgtcag gcctgccgta aataataatg 2285101 cggccgcttc cccgaacacc cttcctgacg ctaaaattgc tcctgtgatg atagaaggaa 2285161 tcgcacttgg aattaaaact gtttttacgg tatgccagcg tgatacacct aaagcgagag 2285221 aggcttcctt cagatcttta gggactgaac ggatcgcgtc ttctgtcaca cgcaccatga 2285281 caggaaggtt aaaaacagtt aacgcaagcg ctccgcctat gatcgtataa ccccagcctg 2285341 ttaagttgac aaacatcaat aatccaaaca tcccaatgac aatagacgga agagatgaaa 2285401 gcacctctat acatgttcta atgaagtcag ttactttgtt attaggcgcg tattcagcca 2285461 tgaagactcc gccgcccaca ccgagcggga ttgtaatcag cattgtaata aacaaaatat 2285521 aaaaggagtt aaacagctga tctcgtatgc ctcctccagc tgcaatggcg ctcgactttg 2285581 ttgtaataaa ttgaaaactg agctgagaaa caccgtttat aataatatag gaaaacaaac 2285641 ctactaaaat ggcagcgata atggctgcac acaaaccaaa cattccggtc gccagtttat 2285701 ctgttatttt gcggttcatt acactttcct cctagatgac aagtagcgaa taagcaggat 2285761 gaacaagaat gacatcacca gaagcacaag ccccattgac cacagcgtat tgttttcaac 2285821 acttccgtat gtggtgtggc ccatattcag cgtgatgatc gttgtcagcg ttcccgcagt 2285881 gtcaaacggg ctttccggca atactcttgt atttccaatg accatctgaa cagccaaagc 2285941 ttcaccgaac gcccgagcca tgcctaacac aacagctgtc atcaatgttg gaaaagctgc 2286001 aggcacaagt acttttctga tcgtctgcca tcttgtggca ccaagcgcgt aagaaccctc 2286061 tcgtaaactc ttcggaagag aagccattgc atcagcagaa atcgatgtga tcgtcggcag 2286121 aatcatgacg gaaaggacaa tcgttcccgc caataaactg tgccctgttc cgctcgattt 2286181 gaactgggcg ataaacggca ccaatactgt aagacctatg aatccataaa caacagatgg 2286241 aataccgact aaaagctcaa tcaccggctg cagcactttc tttccccaat tcggggcaat 2286301 ctctgtcata aaaatcgcac ctgcaatgcc aagcggcgca gcgattagag cagaaagaat 2286361 cgttactgca aatgagccaa aaataaatgg cagcactccg tatttcggat cactatctgt 2286421 aggattccaa tttaagctcg ttaagaattc aattgggctt acaccattta caagaaaaga 2286481 ttgcagcccc ttaacgccga ggaaaatggt aatcgcaaca gatgccgcaa tcataatcag 2286541 tgcacaagct gtgactatca ttcttccccg aacttcatcc aattgccgat tttgcctaga 2286601 gctgattaag cgctcgctca cagacatatt ttctctattg tttatcattg ttttacactc 2286661 ctatgaatgt gttaagagga gaaacggttg tccccgcact cctcttttta ttaagatcag 2286721 ctttgcttcc cgttggcatc acgtgtcact ttcatatcag taaccggaat gtagccttgg 2286781 tcagtaacaa tgcttttttg aatgtcttca ctctttagat aatcaagaaa ttctttagct 2286841 aaacctgtcg cttcaccttt tgtataagaa tgttgataag cccagatcgg atactcgcca 2286901 gttgctacat ttttcgcttc aggtttaaca ccgtcaatag atagagcagt tactttgtca 2286961 tctgttaaat atgagaatgc aagatatcca atcgctcccg gagtatcagc aatgatcttt 2287021 ttcaccgtgt tggaggaatc ttcagtaatg ccttctgcag gctccgctcc gtcaagcgca 2287081 tatttcacaa atgtagcacg tgtgccggaa gaatcagggc ggtttacaag tgtaatcttt 2287141 tggtctttgc cgccgagctc tttccagttt ttgattttgc cagtgaagat ttttttcaat 2287201 tcatcttttg aaatatcctt tacaccagca tcagggttta cagctgctgc cataccaact 2287261 acagcgactt gatgatcgac aagcgctttt gcatcgatgc cttctttttc ttcagcaaaa 2287321 acgtctgaat tcccgatctg aacagctcct tcagagactt gagaaagccc tgttccagaa 2287381 ccgccagctt gtacctgtat atcagcatca gggttttctt ccataaattt ttccgcggct 2287441 gcaagtacta gtggctgcat tgccgatgaa ccagaaatgg ttaaagaacc tgatgccttt 2287501 tcttctcctt ttgcagaatc gctattcgat tttttacttt ctcctgcatt tccgcatgca 2287561 gctgcaatca tcataaaagc agccatcaga agcataagca ccaatttgtt ttttttcatt 2287621 tcctgaattc cccctgcgta taatgtgtaa tttgtcctac acgtatagag taaaggttct 2287681 atgtaaaaag ggtttgaacc gaatgttaag gttttgtaaa tcagtgcgtt tttttgtata 2287741 aaaaaaacgc ccacatcatg tgagcgtttt tttttagtta tcagaagacg ttgtgttttc 2287801 tgcattttct tcaattttgt ctttattctt ttgctgagta ccttctttgt cctgcttcga 2287861 tttcagctca aaatatttat ccattacttc cctgccgatt tcgtttgtaa ttgagtatct 2287921 ttgattgtaa tcaatgtaag tccaaggaac tacgacagaa atagcaatct caggattgtc 2287981 agctggtgca taagccacaa gcgtcgtatt ataagtgtct gttcctgttt ttgatttatc 2288041 cggtccgtcg taaaatgatt gggctgttcc tgtttttgca gctggtttat acgatgctga 2288101 agccagttga cctgcagctg tccctttagt ggcaacccgt ctaaaaccgg cttggacctc 2288161 ttcaatatag ctactcttca tatcgacttt attcaatact tcaggctgaa cagaatcaac 2288221 gactgcgccg atcccttttt tcgcatttga atctctgact tcctttacaa gctgaggctt 2288281 catgcggtag ccaccatttg ctatggtgga gacatattga gccaattcca gcggtgtata 2288341 agtatcatac tgtccaatgg cgaaatcaag caagaaacca gataatctgc ttgtaccttt 2288401 atatcccgtc atttcatttg gtagatcaat tcctgttttt actcctaatc caaattgact 2288461 gaaataattt ctgaaggtat caaatgcaga agtatccaaa ggcaatgctt ggtgaggttt 2288521 atattcacct ttaccaactg caattgctgt tttaaacata aaaacgtttg atgacttctc 2288581 taatgcagtt tgaataccaa ccggccctaa gttttgccaa gattttttcc ctcttttatc 2288641 ctggccgata tacaatggtt catccttaaa tacagtattc aaattaatcg ctccagtttg 2288701 aagaccggtc aaaacggttg caccttttac agctgatccc atagcgtagg atgaagtcat 2288761 ggctcctaat gcataatcat caaacttata ggctccattt tctcgtttaa tctgcttccc 2288821 tgccattgtc agcacttcgc cgtttctagg gtccatcatg acaacgaatg cacgatccaa 2288881 caattcggta ctaggtcttg ctttagcagc tttaagtttt ttctcaataa ttttttccac 2288941 tgatttttgc aaatcaatat caattgttag tacaagatct ttcccggctt tgccttcaga 2289001 taccgttttt gttcccgtga cattgccttt tgaatctgtg atattttcga cttttgcttt 2289061 ttggccctgc agaaggcttt catattggta ttccagatag ctttttccga ccctgtcatt 2289121 tcggctgtag ccaagcgaca gataatggtc gagcaagttg gacggcaatc cttcattaga 2289181 gctggaaaca cttccgagca ctgagcgaag aaggttttta taaggatatt cacgttccca 2289241 atcggacgtg acatcaacac ctggcagttc gtctaaatgt tcacttacca ctgccatttc 2289301 cttcgctgat acatcttcgt ttttgatata ttgaggggtc aatgcatagc ccgaatccat 2289361 ctgtcttttg atagcaagga tctgcatatc tttatccgtc aattcattca gctgcttatc 2289421 agtaatccgt tttagctgaa gctggtataa atcgtcatcg gatatttttt tgtcttcaac 2289481 ctgctgtctt tctttagagc taatgagctt tttcgcttct ttcggtctag tcaaaatcca 2289541 ataatctttt ttatcccgtt ctgttacttt ttttgtatcg actttgatca tgtcagacag 2289601 cttttttgcg atctttaagc gctgttcttg cgtggtcgat ttagatctcg tgtatgtgat 2289661 tgcatttaaa gccttatttg tcacaatggc attaaagttt cgatcataaa ttttcccgcg 2289721 tggtaccgct gagctgactt cactttgttc ctgcttattc gcttggtttt tgtaatcatc 2289781 accttgcacg atctgcttga tgcccagttc cacaataatc caggtaaata taacaaaggc 2289841 agctaaaaat aaaatattca gccggatcgg aagcgacttc tttttctctt tatgattttg 2289901 cttttttggt ttatttctcc tcataacatc accttttcta tttacagaaa gaaaagacac 2289961 tcaagtaaga gtgccagttt tcattttaaa ggttttttcg acttttttct acagataacc 2290021 cctttttggc aaaaaaatta tctctcgcct tttaaaaggg tcggttctgt tacccgtttt 2290081 tggccgtctt cttccatggt ttcattttcc ccttctttct ccttaaaacg aatatccttg 2290141 acaaagtaat aaatcaaagg atgtcctata cccaatatcg caagtgacaa aggaattccc 2290201 acatcctctt tcagaagggc cacaatcagg agaaagcaca aaatggaaac aattctgccg 2290261 gcgttcaaga acatttctct aagcacgata tattcaattc ttgcttttct ggcatgcctc 2290321 gcgcgcccta tcacatcata tgtaagtgat acatatggca caagcaacag aggatagccg 2290381 atggcaataa aaacgccgta cgttaataat gtcgaaaagc tcatatggaa cagaatcaaa 2290441 aacagcgcgc catacaaaat aagtccgccc agcaaaatcg atttttttct cgcctttttc 2290501 ttaatcagcc tggatgcaaa gtagtaggca aagaaggaaa cagctgaatt gacaagaccg 2290561 aatgtaccga gagcaagctc gctgtttgtc tcaataaata caaacacact gattaaaaag 2290621 acaaaaatcc cttctctcaa accctgaaaa aaatgcgcat tcgtgattct ccgccaattc 2290681 atattgctat ggcgctctcc aaatactttg ctcagcataa aacggccctt tgattctctc 2290741 cgttttaaga aaaagctcat cacgacagcc agggcaaata aactgaggga gagactgaaa 2290801 atcactgtat aacccgtatt attttcaagc cttgagatca cgaatccggc tacaatcggg 2290861 ccgatcattc ctgcagagga agacagaatg cccataaacc cgttgaaaaa gtctcgtgta 2290921 tccggctctg ttatttcaaa ggtcagcacg ttaaacgcta gccaataaaa gccatagcca 2290981 actccgagca ccgcgccgat tagcacgagg cggctggccg ccgtttctcc ggctaaaagc 2291041 acacttaaat aaaaggcagc taaaaaaatg acgccgaacc ttaaaatgaa taccctgtct 2291101 atttttttgg ctaaccgtcc agccaaataa aaggttatcg gctgcattgt cacaatggat 2291161 aaattatata tcgccaaatc aataaatttc cctgactgct tccaaagata cacattaaca 2291221 aatgtattgg acagtgcaat tcccagcgag taaagcccgc caatggtcag cagaaagagt 2291281 aagcctttgt ttacgtctac atcgcctatc acttttttta gtttgctcat tactgactcc 2291341 cctttactat cccttagtct gtctcactca aaccgagata tgtaaaaaga agacataaaa 2291401 aaacaaggtc ccataatgag gaccttgttt gtgccattat tttgcttcgc tgtatagacg 2291461 agccacttcg tcccagttta caacattcca gaaagctgaa atgtaatcag gacggcggtt 2291521 ttgatagtta aggtagtaag catgctccca aacgtcaaga cctaagatag gcgttttgcc 2291581 ttctgaaagc ggagaatctt ggtttggcgt gcttgtgatt tcaagtttac cgttgttcac 2291641 aacaagccat gcccagccag aaccgaagcg tccagctgct gctgctgcga attgctcttt 2291701 gaatttgtca aagcttccaa atacactgtt aatctcttca gcaagcgcgc cagtcggttc 2291761 gcctccgccg tttggagata aaagtgtcca gaataatttg tggttcgcgt gtccgccgcc 2291821 gttgttgcgg actgcagtgc ggatgttttc aggaacagaa tcaagatctg caacaagctc 2291881 ttcaactgat ttgttggcaa gagcagtgtt tccttcaacc gctttgttta aatttgtcac 2291941 gtatgtgttg tggtgtttcg tatggtgaat agtcatagtt tccttgtcga tatgcggttc 2292001 taaagcatcg tacgcataag gtaattctgg aagttcgtaa gccatgataa ttcctcctta 2292061 gtatatatgt actgaaatgc cgcttcacag cgagcctttc ttcattcaat gtaacaaaag 2292121 aatgctttgt aatcaatgaa aaagctcacg atttggctca tttcagcgga catatttcac 2292181 tttaaccgat aatctgcccc attaaacctg ccgccagcat ttcttatagg accgtccata 2292241 aaaagtaacc gatcatcaaa agctgtatga tgccctttgc aataacccct gttaaaaaac 2292301 caatgagtga gccgaggcca attttaaacg ctgactttaa gtccttctga tggacgataa 2292361 gttctgcgca aacagccccg ataaacggcc ccaatatgat ccctgcaacc ggaatgacaa 2292421 aaggcccgat taataaaccg atcgtgcttc cccatatggc agctttgctt cctccgaacc 2292481 tttttactcc aagcagattc gacacgtaat ctgctgcgaa taatactgcg gcaaaaactg 2292541 cctcaacaag ccagaacata taagaatacg gactgaatga aaataaaaat ccgtacaata 2292601 caaatccggc aacaataaat actacgctag gaataacagg atacaccagc ccgataaagg 2292661 caatgataaa aaccgctgca atcaacagcc aatacaacat atccatagct tccatcctcc 2292721 cattttactc tgtcttcttc atgtcttcct tgtattcaca cgcatgcaac gatacaataa 2292781 gcaacatata ttagtttagc taggaagtga agatagtgaa tgtgtttcag cttttcatta 2292841 aaagtacata ctctccccgt gatattgcaa aaacaagatt tcaaggaatc ggaaaagcga 2292901 ttctttatgt atttttgctc tctgtcctgt ttgcaatccc taccgcttat tatgtaagta 2292961 cagggaccgt aaaatcaatg aacggcttta aaactgtttt aaacaaagat ttccctgatt 2293021 tcacaatttc aaacggcaaa cttcaaacgg atgagaaaaa agccacggaa tctcaggcaa 2293081 atggtttcgt tatcgtgttc gatccgacag actcctatgg cactgaacaa attgaagcaa 2293141 agcaaaacgc aatcggcatc cttcagaaca aatttgtttt ggccattgac ggacaagccc 2293201 aagaaatgtc ttactcaatg atgccgtcag agttacagaa aaaagatgtc attgcaggtt 2293261 taaaccaaaa taaagcgatg attgtaactg ttctctcagc tcttattttt ctcgtaacag 2293321 cagcgggaaa atttattgaa gtatcgtttt tagcgcttat cgggttaatc attaagaatt 2293381 cgcagaaaaa acatttatcc tatcatcagc tctggaagct ttctgcttat tccatcacac 2293441 tttcaactgt attctttaca atcatgcggg cactagaagc aaccgtacca agtgaatttt 2293501 tgctgaactg gtttgtcaat tttgtcatcc tgtttctcgt tttaaaagag attccgtcca 2293561 aaaaagtaat taataaaagt taaattatat ttatttttat cctttaagta gagagtgtga 2293621 aagcatttgc attaactttt tacttaaggg atatttaata aaatgtatag agcttaaaca 2293681 gatacattta taaaaaaagc tctacaatta ctcaagaaca agctctggac aataatatca 2293741 gaagtagtaa gatgtaacat gaaagaagtt cttaacagca tttgacatat gtttttaaca 2293801 aaataagaat aatgttaaat tttaactaat agactagtta aaatcatatg gcaaaatatt 2293861 ttgcatcctt tcacaacata tttacataag atagttgcta tttaaaaagc caggtaccaa 2293921 tagggcacct agctttcaga attaaatcat caacaagtta gaattatctt ctttccttct 2293981 attctcatta ttgaactgtt atcttttttg tgggtttatg tatacaaatg cagctccctt 2294041 agctttcccc ttatatactg ataaacctac tgcccaaggt gttcctgtcg gttttggtaa 2294101 tttactgaag taaaactttt tggttggagt tctacttgaa aagtaccctg aatattgcgg 2294161 gccaatgtcc ccaccctcaa ctatagatac accaaagctc ttataattta gtttaccgca 2294221 ttttccattt gtttcggcgt aagcatcaat agatgttgca ctcttagtat atgtataagc 2294281 atctgtaata actcttattt tacaaccaga aataccactt accggttgcc aaccactgct 2294341 tgcagcctct gctttttctt taggtgcaac taccaaagtt aacattagta gcaaaattaa 2294401 aaacacagaa aattttcctt gcttcatttt gtagatcctc ctttaaacta ttacataatt 2294461 atcctaacag atccattgtt cattgtaaat aatggaatac gagttttata ttataaaagc 2294521 ctctttttga tctaattttg cactattttc tattttctat ctgaagttaa tgtttagtcg 2294581 aagaaatcct gtcaaaaaag cgcctgtata aaaaccgagc attcgcagtc tcttttcttt 2294641 tgtcatgaat cgaaatggac aagcatacta tggtataaaa tttcgtatgc gggaggaaaa 2294701 gcgatgaagc gtctcacctt agtatgcagc attgttttta tactttttat tcttttttat 2294761 gaccttaaaa ttggaaccat acccattcag gacctccctg tctatgaagc atcagcaaaa 2294821 acggctgtac aagaaccggc ttataaaacg gtgaaggtaa agccgggtga tacggttatg 2294881 tcgatagtcg gatcagcagg ttctccggat gacattgtaa aggattttga agcactgaat 2294941 ccaaatgtga aagctaacgc cattcaagcc ggaacagcgt ataaattccc ggtctaccct 2295001 taatttaacg ttaatttctt gtcagttcgg cgaagacact gttacaatgt aatttgtaaa 2295061 ataaattcac ataaaccata ctagaattgt tatatctaga agcggcaact acaattaagg 2295121 agcgattgca agtgagtgaa atcacacatc gtacaaaaac gcgtcccgtc aaagtgggac 2295181 ctttaacaat aggcggcaac aatgaagttg tcatccaaag catgacaaca acaaaaacac 2295241 atgatgtaga agcaacggtt gcggaaatta accgtttggc tgaagccgga tgccaaatcg 2295301 ttcgggtagc atgtccggat gaacgggcgg caaacgccat tgcggatatt aaaaagcgca 2295361 tttccattcc tctcgttgtt gacatacatt tcgattataa acttgcgttg aaagccattg 2295421 aaggcggcgc agataaaatc cgaatcaacc ccggcaatat cggccggcgc gaaaaagttg 2295481 aagcggttgt taaagcggcc aaagacaaag gcattccgat cagaatcgga gtaaacgccg 2295541 gttcattgga aaaacggatt ttagaaaaat acggttatcc gactgccgat ggaatggtag 2295601 aaagcgcact tcatcacatt aaaattcttg aggatcttga ttttcacgat attattgtca 2295661 gcatgaaggc ctctgacgtg aaccttgcaa tcgaggctta tgaaaaagca gcgaaagcgt 2295721 ttgactaccc gcttcacctc gggatcaccg agtcaggaac actgtttgcc ggcacagtaa 2295781 agagcgcagc aggactcggc gccattttaa gcaaaggcat cgggaacacc atgcgcattt 2295841 cactaagcgc agaccctgta gaagaggtaa aagtagcaag ggagcttctg aaatctttcg 2295901 gcttagcctc caatgctgcc acgctcatct catgcccgac ttgcggccgt attgagattg 2295961 atctaatcag cattgccaat gaagtggaag agtatatttc taagataaaa gcgccgatta 2296021 aagttgctgt tctcggctgc gctgtaaacg gacctggtga agcgagagaa gctgatatcg 2296081 gaatcgccgg cgcacgcggt gaagggctgc tgttccggaa agggaaaatt gtccgtaagg 2296141 ttccagagga aacgatggta gaagaactca aaaaagaaat tgacattctt gctgaggaac 2296201 actacgcaaa acttgaagct gaaaaagcaa aattaaaaga agaaacacaa aaagcttgac 2296261 gggaacccgt caagcttttt tgtgttagaa aaatggaata ataaatattc caagcactaa 2296321 tgaaacgaca ccgataccca ttgcccaggc tccaaggcct tgagcacctc ttcttcttgc 2296381 gatatagccg acaataatac cagcagctcc caataaaaca ggcagtacaa acaatgaaat 2296441 gatggacaag gctaaagcga tgtaccctat tccccgtcct tcattgacat tgccgccgct 2296501 gcgatcattg tcttggtcat tgctgcggtc agcagcacga taaggctctg cgatttcagc 2296561 agctgtttcc tcaaaaaaac cgtcattgtc gcgggtaata tttgtccctt cagatccatg 2296621 atcaacatag taactgttgt tatcacgctt ttcgtaatcg tttgccacct tcaattcccc 2296681 cttctgtttt attaaaggag cttttatagt ttgatccatt ttgcctgatt catgtttgct 2296741 aaacttttct gttaatgtca attgtttatg ttacacttga agggatgaaa ctgaaggagt 2296801 gtgggcatgt tacgcttagg aatagatatt gacggcacaa tcacggctca ggatacattc 2296861 gtcccttatt tgaaccgttc gtttaatctt tccatttcat taaacgatat gacggattat 2296921 gatttaacaa agctgttaaa cattacccag gaagaatttt gggattggat gaatcaaaat 2296981 gaagcgatca tatataagga agcattgctt gcacagcatg cgaaacagtc tctcgatctt 2297041 ctcaaagagg agcacaagct tatttatatt acagcgagac ggactcattt aactgatatt 2297101 acttatgaat ggtttgacag acaaaacatt cattatgacc acatcgaact tgttgggggt 2297161 catcacaaag ttgaagcggt caagaatcat aacatcgacc tgttttttga ggatcatcac 2297221 gggaacgcca tgatgattgc gaaagaagcc gggataccgg tgattttgtt caattcccct 2297281 tataatcagc ttccgattga ttcaaacatc atcagagtaa acaactggct agaagccgtt 2297341 caatggatga acaacaacaa gcatcactta atacgcgtca ataactgaaa aaggagccca 2297401 aaccgggccc ctttttcata tatacgcatt ttacgcagta gtgttttctt ggttttccgc 2297461 tgtacaatca gggcatgtgc cataaatctc aaatttatgc ccgctgacct gatagccatc 2297521 caaatcatca caaagcttgt ccatcggaca tgattcaatt tcctttgttt tgccgcaggc 2297581 aagacaaata aaatgatggt ggtgatgggt gaatgaacac ttaaatcgga agagcttttc 2297641 accggacagc tcagttgttt ccaaaatccc aagttcttca tataaagaaa gatttctgta 2297701 gattgtatca aagcttaagc ctggataatc atcattcagt gcagacagta cgtttttagc 2297761 ggtaagatat ctgtctgaat cagcaaaaag ctgcagcata tcctcccgtt tgtttgtata 2297821 tttatatccg ttttctttta ataggttcag cgcttcttgg acgttcatga agggtccccc 2297881 ttttcgcttt gcttaagaac gtatcacatg tatgaaaaag aaaatggcag ctgtctgtcc 2297941 agcaagccat tttctttact gcagataaaa ttatacccat aaaatgaata aaagtaaatg 2298001 aaagcctagt ggattgcgtt tttgaatttt ccgcctctcg tttcatgagt attcataatt 2298061 gttatgaatg cattttgatc aacttcaaac acgatcgatt tgagctttgt cacttccagc 2298121 cttgtgacaa ccgcgtaaat tacgtctttt tcttcgtccg tatacccgcc tttccccttc 2298181 agcttcgttg tgccccgacc gagacggtgc aaaatcgcgt cggaaatctc atcatactgc 2298241 tcagacacaa taatgacagc ttttgtttca tcaagccctt ggatcacggc atcaatcgtt 2298301 ttcatcgcaa tataataagt catgaatgag tacatcgctt gctcaggacc gaacacaaaa 2298361 actgcccaaa tgaaaatgaa cacattgatg aacataacga actcacctac agaaaacggg 2298421 agttttttgg tcagcaaaat accgagaatt tctgtaccat ccattgaacc tccatttcga 2298481 ataacaagcc cgacgccaaa gccgagtaaa agacctccga acacagtagc caaaataggc 2298541 tgggttgtaa tggcttctac atggtgaagt gaggattcaa taacggcaag cccgacaatc 2298601 cctataaacg tagagactag aaaggtctta ccgatatatt tatatccgaa gatcataaaa 2298661 ggaatattta atatgacaac gaaaaaagcg aaattcagaa aggggtttga cataaagagg 2298721 tggtctaaaa taagagatac accgataatc ccgccatcaa taaaatcatt ggggattaaa 2298781 aataattcaa tacttacagc cgcagatgca gctcctacca gaatcataaa gaccctgaaa 2298841 ataaaatggg taaatgtttc tttcttatgt tgttttgttg gggtcataaa atctcctttc 2298901 ctgcaataac tattttaaat acattataaa tctattttac cattaaacac tgacacattt 2298961 tactgatttg cccatacatt aagtctggag gtggaatgac cgatgatttt atttcaaaga 2299021 attattttgc agcggcttaa tcaggctact gctgatgatt tgctgaagta ctcaaaacaa 2299081 tacggaatca gcttaacaag atcgcaggcc gttgaagtag cgaacctgtt atacgggaaa 2299141 aatgtaaaca tctttaatga gagtgaacga atgcggctgc tgaaacaagt agagacgatt 2299201 acatcgaaag aaacagctca aacagttaat gaactattca aacaatttac aagctaaaaa 2299261 atgggggtgt tatcccccat tttttattgc tgtaaaatct tttcaagcaa tgtatcatca 2299321 aattgttttt ctttcagcat ttcaatctca aaacggtatg gcggtttttt gttcttttta 2299381 tcttcaccga cgtatggtgt ttcaagaatt tttggaatgt cttttaactg ctcatggtga 2299441 acaacatatt gcagtgcgtc aaaacctatt tcaccaaagc caatattttc atggcggtct 2299501 tttctcgcac ctttgacatt tttgctgtca ttgatatgaa gcactttaat acggtcaatg 2299561 ccaatgattt tatcgaactc atttagcact ccgtcaaagt cttcgacaat gttatacccg 2299621 gcatcatgtg tatggcacgt gtcaaagcac actgacagct gctcattgtg tgtaacgcct 2299681 tcgataatct gcgcaagctc ctcaaagctt ctgccgcatt ctgatccttt tccagccatt 2299741 gtttctaatg caatctggac attttgattc ggatcaatca cttcatttaa gccttcaata 2299801 atttttttga tgccggcttc agctcctgcc cctacgtgag cgccaggatg aaggacaatt 2299861 tgcttcgctc cgatggccgc tgtccgttca atttctgaac gaagaaaatc aacacccagc 2299921 tcaaaagtgg acggatttgt cgtgttgcca atattaataa tataaggcgc gtgtacgata 2299981 atctcgtcaa tgccgttttc ttgcatatgt gcccggcctg cttctatatt taagtcttca 2300041 attttctttc ggcgcgtatt ttgcggtgcg cctgtataga tcataaacgt attcgcccca 2300101 taagagactg cttcctggct tgcagccaga agcatatgtt ttccgctcat agagacgtgt 2300161 gagcctattc tcagcaacag gttcccctac tttcttttct tagattggtt tcttctctgt 2300221 tttttcttga ttttctccat ctcatagctc attttctttt tatacccagg cttaaccttc 2300281 ttcggctttt tcacgagacg atgagcaatt tcatccgctt cattcggcgt ttttttacgt 2300341 tttttgcggc gctgacggtc atcgcctttt ttccattcgc ccttttcaag ctctaagtac 2300401 tcaaattcga tgcccatttt ttcaagtctt actaatgcat cctcatcagt aagctcataa 2300461 atggtcatcg cttgtcctga tgagccggca cgagccgttc tgcccacacg gtgaacatag 2300521 aaatcgagat catccggcag ctcatagttg ataacatggc tgacaccttt aatatcaata 2300581 cctcttgcgg caaggtcagt tgcaatgata tatgtgaatt ccaaatcatt gatctgcttc 2300641 atgacttttt tccgctcacg tggtgttaat ccgccgtgca gcaagccgat tttcatgcct 2300701 ttgccagtca gatactgggc aatatggtca gccgtatttt tcgtgttggc aaacacaatc 2300761 cccaggtatg gattcagatg cgacatgatg tcaaaaagga gcttgtcctt gtcacgatgt 2300821 ttcgaaggaa tgaggatatg ctcgattttc gcagcagtca cctgttttgg ctccacatgg 2300881 gcgtatttcg gattttccat gtatttcttc aagaatggtt tcagcttttc cggtatggtc 2300941 gctgagaaca caagcatttg cagatcctca ggcatgcggg aaccgatgta atctacatct 2301001 gcaaggaatc ccatgtccag cattaaatcc gcttcatcaa taacaagaga ttccgcttta 2301061 tgaacactta acgcctgttc tttgattaag tcagcaatcc gtccaggtgt accgacaaca 2301121 agatgcggct gtattttcaa tttatcaatt gatttttgtt tatcagtgcc tccgataaaa 2301181 catttcgagc gaatctgact tccttcttca ccctgcgtga ttttaagcgc ttcctgataa 2301241 atctggttgg caagctctct tgtcggagcc gtaatgacta cctgaacgac atccttagca 2301301 ggatcgattt tgtttaataa aggcagtaaa taagcgtgag tctttccagt acccgtctga 2301361 gactggccga tgacgctttc tttttttaac actgcaggaa tcagcctttt ctggatatca 2301421 gtcggttcgt aaaaaccaag gcgatgtact gcatctataa taaatggttt caattcataa 2301481 agttcaaatt tcgtttcttt catttttccc agctccttaa agcggcacat tatgtgtcca 2301541 tcatcacatt atacccgatt ttgcttaaaa acaccacgtt tgcaaggcgt ttgttttatt 2301601 cagttatgta aagcaaatac cgcagcccat gcatattcta atagcagaga gagctgaaag 2301661 gaggtacaag tatgttttca ccgcagcagc caatgagaaa ttacccacag cccggaccgc 2301721 cccgccccat gccaaatcag cgaatgatgg gcagaagacc gcctaatatg cgaggacctt 2301781 catttggagc acagcagcaa ggttttcagc aagccggaca atttcttcct caggcaaatg 2301841 ccggagcgag aaatggtgca ggtgcaggcg gaggcttaaa aggaatgctg tcaaggttcc 2301901 tccccggcgg aggaggcgct ggcagcgccg gggttcccgg aattccagga gcaggtgcag 2301961 cagcgagcgg aggtgctggc ctgcaaggca ttcaaaatat tgccaatcct gcatcattat 2302021 ccagtatgct tggaaatgtg caaaaagtac tcggcatggc gcagcaagtc acccctatga 2302081 tccagcagta cggcccatta gtccgcaatc tgccagcaat gatgaagctg tacagccaat 2302141 taagtaaaag tgatgatact gagacagagg ccaatgagga aagtgaaaaa caatccgttt 2302201 cagaagaatc atcagaaaaa gaaaaagaga ctgaaacaaa aacctcagat gggaacaaaa 2302261 aatcaaaacc aaaaagttct tctctcccaa agaaatctaa aacaactgac aataaagaac 2302321 aagaattaaa aacatctgcc ccgaagaaaa aggaagctgc ctctcctgct ccgaaaagaa 2302381 catcaggcag ttcaaaaccg agattatata tttaacattc tttgatatct taagtgagat 2302441 tggctataat gagatcagaa gaatgcaaga atagagccgt ttgattacgg ctttttatat 2302501 tgcctttact cacttcagta ttggaggaca accgaaaatg gacgtaatta aaatttcacc 2302561 gcgcggctat tgctatggtg ttgttgatgc tatggtcatt gccaaaaatg cgtcgctaga 2302621 taaaagcttg ccaagaccca tctatatact cgggatgatt gttcataata aacacgtcac 2302681 tgatgcgttt gaagaggaag ggatttttac attggacggc tctaaccgtc tggacatctt 2302741 aaagcaggtt gacaaaggaa ctgtcatttt cactgcgcac ggtgtttctc ccgaagtcag 2302801 aagaatcgca gaagaaaaag ggttagtcgc aattgatgct acatgtccgg atgtgacaaa 2302861 aactcataat ctaatcttag agatgaaaga aaaaggatat cacgtgatct atatcggcaa 2302921 aaaagggcat ccagagcctg agggagccgt tggcgtagcg ccggagatcg ttcacttagt 2302981 tgaaacagaa gaagatgtaa agaaccttga tatccaatct gagaagttaa tcgtgacgaa 2303041 tcaaacaaca atgtctcaat gggatgttca cgacattatg gagcttgtca aagaaaaata 2303101 tcctcatgtc gaatatcacc aagagatttg cctcgctact caagtgcggc aggaagctgt 2303161 atcagagcag gcaaaaaaag cggacttaac aatcgttgtc ggagacccga aaagcaacaa 2303221 ttcaaatagg cttgctcaag tgtcagagga aatagccggg acaaaagcat accggatcgg 2303281 cgacttaagc gaattgaagc tcgaatggct gaaaggcgtt aataccgttg cagttacagc 2303341 gggagcttca acaccgacgc cgatcacaaa agaagtcatt cgctttttag agcagtttga 2303401 tcacgaagat ccatcaactt ggacaactga acataatata ccgctcaaaa aaatacttcc 2303461 aaaagtaaaa gcaaaaaact gaggctgtaa aagcctcagt ttttttatag aaatgtaaat 2303521 ggatttgtat ctgtttcaga aacaaagata ttcacgccaa actttttatc attacacatt 2303581 gatgtaagtt ttctcgtgac gccttctttc atgatttttt ccgcgtaatg gcccggatca 2303641 accacattta ggccaagcat catcgcatca tgggccacat ggaagtataa atctcctgtg 2303701 acgtaaacat cggctccctt tcgttttgca tgatgaatat acttgtttcc atctccgcca 2303761 agaacagcta cttttttcac catgctgtca gcatccccaa ccattctgac accattgacg 2303821 tcaagcttgt ctttcacaaa taaagcgaat tccttgagcg tcatctcatt tttaagggtt 2303881 ccgacacggc cgagcccttt ttcggcggga gtctgttcga caggatagat atcgtaagcg 2303941 acttcttcat atggatggct ttttatcatt gcattgataa cagccttttc gacgctttta 2304001 ggaaatacag tctcaagcct tacttcatga acaagctcaa gctctcccac ttcaccgata 2304061 aaaggcttag ctccgtccaa tggcttaaag ctgccgattc cttcagatga aaacgcgcaa 2304121 tggctgtatt caccgatatg gccggccccc gcatttccga gcgcggctct gacctgctct 2304181 tcatattcct tcggcacgta aactgccagc tttttcagag gatccgtata agtaggtgcc 2304241 agcacttccg tctcactcag ctctaatgct tcagcaagca aatcattcac accgccgtcc 2304301 gcaacgtcta aatttgtatg agctgcataa acagcaatat catgcttcaa acacttttca 2304361 attaaccttc cggcaggctg atctgttgaa atatgcttta gcgaccggaa aattggtgga 2304421 tggtgtgcaa taatcaagtc aacctctttt tcaatcgctt catcgataac gctctctaac 2304481 acatcaagtg taaccatcac atttttaatt ggtttgttta aggtgccgat ttgcaggccg 2304541 attttatctc cttcaaccgc ataggctttc ggggaaaatt gttcaaacag ctggatgatc 2304601 tgctgcccat ttacactttt agccatgatc gattacctcc tttaacagct ccattcgatc 2304661 ggcgagctcc tttaattttt gtttgttttg ctctgtatcc gccgcttggc tgatctgttc 2304721 ataaatgctt tgagtgtgct gaagctcttg tgtccacttt ttcaaaaaga cagcattttt 2304781 ttcttttgcc aagaaagggc caacgagcat cccggctgat aaagaaatac cgtcataagc 2304841 cgcatccctg tctcccgctt ctgccaccag cacctcatag cactttccgt cctcttcaag 2304901 gattacctca tctatcagcg catatctttc tttataaagc cactccctga tatgaacagc 2304961 atgaatattc ggctgtaaaa tgagccgttc cttccccgtt aatttgtctt tgcccgcttc 2305021 taaaatgtga gcgatcaaag ccccgcccat tccggcaatc gtaatggcat cagcttcacc 2305081 ttttttaatc acttccagtc cgtctccctg ccttacagaa atgtgcgagt ttaagcctga 2305141 tttttcaacc tgccgctttg cagacaaaaa tgggccgtct gttatttctc cggcaatcgc 2305201 cccgctggct ttatgattca gcaccgcata acaaggaagg taggcgtggt cagagccgat 2305261 atcggccatc accgctccat tcggtatgta ctccgctact gtttgcaatc gtttagataa 2305321 ttttaattcg ttcacttgtc atcacaactt ttctcaatca ttttttcctt tactatcata 2305381 taaaaaatca gcccggaatc caagctgaag caaatgattt tgaaattatt tcttttgatg 2305441 cgggtctgca cgcagcagtc aaaaataaaa ggctgtcgag aacatctcgg cggcctgtga 2305501 atgtataaag agaaaaatag ttcttttatt taatttttga cacccactct gccatatcat 2305561 ccagcttatc ggccggaaca agaccggaag gcattccatt accgcctttt tcgatctttg 2305621 ttttaatttc agcgacatct ttcttatccc ctacaccttt taagctagga cccgaaacac 2305681 cttcataatt ttcaccgtgg catgcgatgc agtttgcctt gtaaatttct tctggtgaag 2305741 cgtttgcatc tttcttttca gcagatttgc tttctcctcc gctcgcaatc tcccgagagt 2305801 catcaagtcc ttttactgat aaaaagaaag ttagaccaat tcctaaaaca gcgatcagca 2305861 aaaatggaat aagcgggttc catttcattt cccttccccc tttttgatcc ttccccctat 2305921 gtaaacactt ctaattctaa cttattttta caaaaagtaa atggattgct atacaaaagt 2305981 tttttattca cactttatac aaaattgaat agaaacatgc ctaaatctct aatatccttt 2306041 ttattctatt gtataatgta ttgtatacgc ttacaataga aaatatggaa ttagattttg 2306101 aaatttttca ccacaatgtt catttgcaaa tgacatcatt tttcagtaaa ataaaggcat 2306161 attatccata tatcttttta aaaaaagaag aacggatctt caagacccgt tccatcttat 2306221 tcaaggaaat ctttcaaacg tttacttctg ctaggatgtc ttagtttccg caacgctttg 2306281 gcttcgattt gtcgaatacg ctctctcgtt actccaaata ctttgccgac ctcttctaat 2306341 gttcttgtac ggccgtcatc aagaccgaat cgaagacgca atacattttc ttcacgatca 2306401 gttaacgtat caagcacatc ttccagctgc tctttcaata gctcgtatgc ggcgtggtca 2306461 gaaggtgaag ttgcttcttg gtcttcaatg aaatcaccaa ggtgcgagtc atcctcttca 2306521 ccgatcggtg tttccagaga taccggctct tgagcaatct ttaagatttc gcgtactttt 2306581 tcaggcgtta aatccatatc ttccgcaatt tcttcaggtg ttggttctct gcctaagtct 2306641 tgcagtaatt gacgctgcac acggattaat ttattaatgg tttcaaccat atgaacggga 2306701 atccggatcg ttctcgcctg atcggcaatg gcgcgtgtaa tcgcctgtct gatccaccac 2306761 gtagcatacg tactgaattt ataacctttg cgataatcaa atttttcaac ggctttcatc 2306821 aggcccatgt ttccttcctg gatcagatca aggaacagca taccgcgtcc gacataccgt 2306881 tttgcgatac tgacaacaag ccgcaggttc gcttcagcca atctgcgttt agattcttcg 2306941 tcaccttctt caatcttttg agcgtaggcg atttcttctt ttgcagaaag aaggttaacc 2307001 cgaccgattt cctttaaata catacgaact gggtcattga ttttaacgcc aggcggtaca 2307061 cttaggtcat taaggtcaaa ttcttcttcg gctttggcaa gctgctgaat attaggatct 2307121 tctgtttctt cattctcact aattaattca acaccttgtt cacctaaaaa ttcataatac 2307181 tcatccattt ggtctgattc aatttcaaag ctggacatac gctcagcaat ttcttcatat 2307241 gtcaaaacgc cacgtttttt accagactct gttaattgct cttttacttg gtcgaatgtt 2307301 aattctgtct cgtgggtttg tttatcagcc attatggatc cctccttcca aagcttgcaa 2307361 cgaattctat aagcggtatg attcttattc ggtccattca ggcgttttct atgtgaactg 2307421 cctttaacaa tgtgcgaata atgaaatgac aattcatgat gaggttaagc gatctatttg 2307481 ctcctccgca aggaatcatt gccaataaat gctcctcatc agttctccag ttattttaaa 2307541 gatcggttca atgtaacgat ttcttgagcc aaagaagcag ctcttaaaaa atctttttgc 2307601 ctttctgctt cggctctttc cgcctctttt tcttttatca ttgaccaatt tctttgattc 2307661 aacacttttt ttacataatc tgataactcg gcttcgctaa gctcttgatt aacctgaagc 2307721 attaatatat cggacaagag ctggcttata tgatcatccg tcaccctggc catcagatgc 2307781 tgaggcgtca gctcggctcc ctcttcataa aaagcataaa gataagcggc taatgcccgg 2307841 tgctcatcaa tattaaattg aaaccctacc cggtcaatca cttttttgat gacgctccga 2307901 tctcgaagca tgtgagcgag taacagcctt tctgcatttt catacgccgg acgcaaacgt 2307961 ttttgccttg cttttgtcgt cagatgcgct cgccgcgttt tagtttcacc gctattgtca 2308021 gcaggtttgt tttgcttgct gaaaacagac agctgctcag ttaaagactc ctgtgaaagc 2308081 gaaaactctg aagcaagctg ctttacatag acttcctgct ctagagaccc tgaaagcgtg 2308141 ctgatttctt tcagtacgtc tttaatgtaa gctaggcggt cgccttcatc ggacaggttc 2308201 tttccttttc ggaaatattg cattttgaac gccattacgg tgacacttgc gtcaataatg 2308261 tcgtttttaa atttttcccc gccgaatttt ttgatgtaat catcagggtc caatccgtca 2308321 ggaatcattg caactctgac tttgcagcct tttttttgca gaagctccga agcttttaag 2308381 gtggcttcat aaccggcttt atcagagtca tagcaaagaa tgatttcttc gacgtttctt 2308441 ctcaggatct tgacatgatc atctgtaaga gacgttccca tcgtggctat gctttccttt 2308501 acatccgagc ttacggccga tatgacatca gcaaaccctt caaataagac tgctctttcc 2308561 tgctttctga tatgaaggcg ggccttataa aaattgtaaa gcagtttgct tttatgaaag 2308621 agcggggttt caggactgtt catatactta ggctgctggc tgccaagagc cctgcctgag 2308681 aaagcaacaa cagccccgtg atgatcatgg atcggaaaca tgacacggtt tctgaagcgg 2308741 tcgaaatatc cgcttccgtc ttcgcgtctg atcaggagac ccgctttttc catttgcgcc 2308801 tcactaaatc ccctctttac aaggaatttc gtgataaagt cccaagaatc aagagcatag 2308861 ccaatctgaa attcattaat cagctctttc gtaaagcccc tagaaagcag ataatccagt 2308921 gcctcttgac cttcttttgt atttattaac aaatgatggt aaaatttctt caggagctca 2308981 tgtgcctcag ccattttttg ttctccagaa gactctggcc gggctccgga atggactgtt 2309041 atatcatctg gaaaatcaat ttggtatttg tcagcaaggt gagaaaccga ctcggcaaaa 2309101 gaatagcctt ccatctgcct taaaaaagag aaaacattgc cgcccgctcc gcagccaaag 2309161 caatgaaaaa tctgtttgtc gggcgatacg gaaaacgaag gtgtgctttc tccatgaaaa 2309221 ggacagagtc caaagtagtt tcggccttgc ttctttaatt gaacataatc acctatgact 2309281 tcaacgatat ctgccgactt ttgcacctga tccacaattt catctggtat ccgatttccc 2309341 atcttataac actccgtcgt acattattcg atgctttagt gcaaaatccc ttcatcgttc 2309401 gacaggattt tttgcagcag tgtaataaat cgttctcgat cttctttatt caatttttta 2309461 ggccctttgg catatacgcc ttttcttctt tgtttgccgg aaaaatgacg gccctctagg 2309521 gcaaaatcaa tcgtgtcttc cttgtaaaga cgacctcttt ccgacataac agagacattt 2309581 ctgttcaaca gcagagatgc taatccgatg tcctgcgtca caacaatatc tcccggtttc 2309641 acgtgatttg cgatatataa atcagcagct tctttatgag gatcaacata cttccatttt 2309701 tcttcattgc ttctggaaag ctgataatgt tcaaatgaag cgacaaaaag aacttgaact 2309761 tcatactcgg atgctgtttg taaaatttca tcttttaccg gacaagcatc agcatcgaca 2309821 aaaatcgtct tttcttgttc attaagaaga gtaattctcc atccctccat taaactcctg 2309881 cataaaagca agcaaaatcg cacatccttt attattgtgg atgtatatga atttgtcgaa 2309941 aaatttccgg gagaaattct tgacatctta cccataatag tttattcgta tcacacgatc 2310001 cttaaaccta aaattaatca ttttatcaca attttttatt ataatacaaa cttcacaaag 2310061 atgctattgt ttttcattat tcccttttgg cacagccaaa aacccaggat agagcgtcct 2310121 gagttatatg ttttttgttt tgagatgatg gataatattt gctgtttcct caaccgcttt 2310181 atttgaaaca tcaacaacct ggcagccgat ccgatccaca atcttttcga aatactcgag 2310241 ttcctctttg attctgttga tatttgcata aatcgcttta tcattaagcc cgagtgattt 2310301 taaacgttct tttctgatat gattcagttt atcagggcta atctttaaac cgatgcattt 2310361 tttcggatca acgttaaaga gttcttccgg cggatcaacc tccggtacaa tcggaacatt 2310421 ggcaaccttc aggcgtttgt gtgcgagata ttgagacagc ggtgttttag acgttcttga 2310481 cacgccgatc aaaacgatat cagcttttaa aatccctctt ggatcacgtc catcatcgta 2310541 tttaactgca aactcgatgg cctccacttt tttgaaataa tcttcatcaa gctggcgcac 2310601 ccgccccggt tcgtatttcg ctgttaaacc gtaggctgtt tccattttat caatcaacgg 2310661 gccgataata tcataatata aaacatttgc tttttccgct tcggctatca aatattctct 2310721 gatttccggc accacgagtg taaaacagat aatgccgccg tctgcctttg caagtgaaat 2310781 cacttcattg atagtgccta tatcttcaac ataaggaatt cttcttacat gagtatcatc 2310841 cgccgatccg ttaaattggc tgagtgctgc ttttactacc aattcagccg tttcaccgac 2310901 ggaatccgat acaacataga tgatgcggtt attcatatta tccccccgtt agtttgcaat 2310961 cttataggat ttcattttca gataaactga caagtatttt ggtcatattt gtttttgtca 2311021 ctctgccgat cacttcaaag cctttatcgg tgtctttgat gacaggcagt gcatcaattt 2311081 gtttttctat taagtgcttt gcaatgtcca tcacataatc ctcgcgtctg cacaccgtaa 2311141 tgttcggcat ccttgtcatg atgatgtgaa cagggaccga tgtaagctcc tgctggccaa 2311201 tgctcgctct gagcaagtct tttcgtgaaa gcaccccgac taaaacagca tcgcggtcca 2311261 ccacaaacag agtacctaca tcttctaaaa acatggtgca aatcgcatcg tacacagaaa 2311321 cgttttcgtg aatcactacg gggatagatt gaaagtcttt cacctgaagc tttttgagtt 2311381 tatccgccaa aagctgtgtg ccggtttttc ccgtatagaa ataaccgact ctcgggcgcg 2311441 cctcgaggaa tcctgacatg gtgagtatgg ctaaatccgg gcgcaatgtc gccctggtta 2311501 ggttcagctt ttctgcaata tgctcccctg taatcggccc gttttctttt acaatctgca 2311561 aaatatgttc ttgccgttta tttagttcga tcgtactcac caccttttca cttcatagct 2311621 atgtaaagaa ataacaatcc atattataac gtaaatatct tgtaatcaaa caaaaaactt 2311681 ataaatgggg aaaagacgat taccgatcac acagcaaccg ccttttctct ctttatttta 2311741 caataagggc attcatattc gcaaaggact tgatctcatc cgccaagctt accatttgcg 2311801 ctaaacgatt tgcctttaat gactcattat ccgctataac cattgtatga tcgaagtaag 2311861 catcgatcgg ttcttttaag gctgcaagtg aagcaagcgc cgcctcataa tcttttttgc 2311921 tgaagttttc ctgcagattt tgcttcgctg tttggtaggc atcaaacagt tttgcttcgt 2311981 attcattttc aaacagatca ggctgaatgt ctccgcggac tccttttttg ctgatagaga 2312041 tcactcggcc taacgcttcg gctgtttcct taaagccagg tgcaccaagc ttttgctcca 2312101 gtacttgtgc tttatgcagc gcagagtacg gctcaagctc agagctttcc agcacggcgt 2312161 caatgacatc atgtctgatt tgttcagcat tcaagacata tttcaagcgc tgagtgaaga 2312221 aatccagcag ttcattttct ttatcggttt gaacgaaagt aagcagctct tcaaatgaaa 2312281 ttccccagtt gcggtcaaga agaatcgcaa caataccgct tgcttggcgg cgcagtccgt 2312341 aagggtcctg ggaaccggtc ggaattacgc cgatagagaa gaatgaagcg attgtgtcaa 2312401 gcttatccgc cattgctaca acagctccgg tgaaagtaga aggcgtttct ccgcccgctg 2312461 atctaggcat ataatgttca ttaactgccg cagccacagc ttcatcttcg ccaagcattc 2312521 tcgcatactt ttcgcccata attccttgaa gttcagggaa ttcatatatc atatgcgtca 2312581 caaggtcgaa tttagaaatt tcagcagccc gcttcacatg ttttaatgta tcttcatcag 2312641 cctgaagacg aacggcaagt ttctctgcga ttgatgtgac tctcctaacc ttatcagcaa 2312701 gagaaccaag ctcttcatgg aaaacgatat tttcaagctt cttcacattt gcatcaatgt 2312761 ttagtttctg atcttctttg tagaagaatg aagcatcaga taaacgtgcg cgcagcactt 2312821 tttcattgcc tcgggccaca ttttcaatcg cgtggctgtt gccgtttcgg actgtgataa 2312881 agtgaggcag caggtcaccg tttttgtctt tgacagggaa gtagcgctga tgctctttca 2312941 ttgtcgtgac aagcacttct tcaggaattg acagaaactc ggattcaaat gaaccgtaaa 2313001 gagctgtcgg gtattctact aaatgattca cttcatcaag aaggtcttcg tcaactggaa 2313061 tgctccaatt gttttcagca gccattgttt ccagctgaga ttgaatcatt tgctttcgga 2313121 cgctaggatc agcaataaca tgctgtcctt tgagctgctc ttcataagct gaaggtgatt 2313181 caattgacac ttcatgtccg aggaaacggt gtccctgtgt tgtccgtcca gactcaacgt 2313241 ttgtgatcga aaatggaatg acatcctgtc caaataatgc gacaatccat ttgatcggtc 2313301 ggatataacg caaatcttca tttccccagc gcatgttttt cgggaaatgc aagcttgtaa 2313361 ttaaaccgct caattctggc agaagcgact tcgtttcttg gccggcttgg aatttttgca 2313421 cgaatacata ctctatgcct tttacttctt tgatgtacag gtcttccaca tttgcgcctt 2313481 ggccttttga aaagccgatt gccgcttttg tccagttccc gtccgcatca agggcaattt 2313541 ttttcgcagg cccttttgct tcttctttta tatcatcctg cttttctgcg acatccttaa 2313601 cgaacacagc aagacgtctc ggtgtattga agagtttcac ttcaccgtga gtaatatttt 2313661 tttctttaag ccagcctgtc agcttgtcgc caagctgaac catgctttca ttcaaaaagc 2313721 gcgccggcat ttcctctaat ccgatctcta aaagtaaatc ctgtttactc atgagaagaa 2313781 ccctcccctt taagcattgg gaaccctagt ttttctcgtt cctcatagta ggtttttgct 2313841 acttttctag ctaaattccg cactcttgcg atatagcccg tccgctcggt aacagagatc 2313901 gcacctttgg catcaagcag gttgaaagtg tgcgagcatt tcagcacata gtcatatgct 2313961 ggatgaacaa gtccgttgtc catttgcttg atcgcttctt tttcatatgt gctgaacaat 2314021 tggaacagca tatcgacgtc tgatgtttca aacgtataaa cagaatgctc atattcagcc 2314081 atcatgaata aatcttttac tgtaaaccct gacgtccatt ccaagtcaaa cacgttttct 2314141 ttatcctgga tataagacgc gagacgctca attccatacg taatctctac agaaacgggt 2314201 ttacactcta atcccccgac ctgctggaaa tacgtaaatt gtgttatttc cattccgtca 2314261 agccaaactt cccagcctag acccgcgcag cctaaagacg gattctccca gttgtcttca 2314321 acaaagcgaa tatcgtgctc aagcggatca attccaagag cacgcaagga atccaaatac 2314381 agctcttgaa tgttatcagg tgacggttta ataatgacct ggaactgatg atgctgatac 2314441 agtctgttcg ggttctcccc gtagcggccg tctgccggac gtctggaagg ctctacataa 2314501 gccactttcc acggctcagg accgatactg cgcaaaaatg tatacgggct catcgtgccg 2314561 gctccttttt ctacatcgta agcctgcata agcacacagc cctgactgga ccaatgcttt 2314621 tgcaaggtta gaatcatgtc ttgaatattc atttcaagca cctccacttt tctttcataa 2314681 gttgactgcg gcagcaacca aaaaactccc gtctctatgc ttgccagccg caaacatagg 2314741 gacgagagtt ctcccgcggt tccaccctag ttgctgagaa caaaatccca gcctcttttt 2314801 taaaattgct caagaatgcc tttcgttgcg tgctcatcct tagcttacac cgccctaagg 2314861 tcgctttcat gaggtaaacg caagtacttc tttctctcac tgcaacatat tttataataa 2314921 atgatcatat aaaaagatgg accaaatgtc aacttttgtt ttcacccata agatgtttca 2314981 tgctttccat ttgatctaaa aagcgctttg attttaaata caatcccgaa tattcttcgt 2315041 aatataaatc aatcacttgc tttaattcag cttttgtttc ctcttttaag gacacattgc 2315101 cgagtctcga cagatcaaaa tagtaaaaga gccttaacag ccttgccgtt tgcggtttaa 2315161 tcggtatcct gtaaggatct ttttcaaaac agcggtggca tataaaacca ttatcacgaa 2315221 cagagaaatg aaaggttccg tcttggcttt tacaatgtac acaatgattc agctcaggat 2315281 acaggcccat gacaccgagc atcttcattt gaacaatgaa ggtgataaca tccggatctg 2315341 ttccttcatt caactgtttt aatgattcta atatgaattc aaataaataa ggatttggct 2315401 ttttttcttc tgtgcctctg tcgactaact cagcaacata ggcagcatat gctgttaaaa 2315461 acaagtcttc cctgatgcct ctcatgctga ggatcatttc cccctgctga agcgttccga 2315521 ggcccgatgt tttttgcatt aagaaagaac catacaaaaa gggctggctg actgctgata 2315581 aacggctgtt cggttttttg gcgcctcgtg ccataacacc tatttttccg tgttctcttg 2315641 tcagtaatgt tacgatttta ttcgtctctc cgtaatcatt tgtgcgaaga acgatccctt 2315701 cacattttgt cagcatttcc gcaccttcct caagcaggag cggccaagag gtttataaaa 2315761 ttggataatc aaatcgggct agctcatctt ctagttcttc gggtctttcc atgttctctt 2315821 tttccagttc tttaaaaaga agatacgtat caacatttcc tgtttgagaa aatacgttcc 2315881 aggtaaaatt caacacaaga aacccacctt tctgtagtta aactagctta cctaaactcc 2315941 aaattcttac ctttatcttg accagatgtc ctccatttca tgttaaacaa aatttgctaa 2316001 tgtatccctg ttcctgtgag ataatgacac acacgggaag agattaatat tcgtcctctt 2316061 taaagccaaa atcgcgaagc tgggacattt tattacgcca gtctttctgc actttcaccc 2316121 acaattcaag gtagacacgg gagcccaaca gtgcttcaat atccgctctc gctctttttc 2316181 caacctcttt tagaaggctt ccttttttac cgatcacgat gcctttctgg gaatcccgct 2316241 cgaccacaat cgttgccgct acgtgcacag aaccgttgtc ctgccctttg atggattcga 2316301 tggccaccgc aatgctgtgc gggatttctt ctctcgtcaa atgcagcacc ttttccctga 2316361 ttaattcaga aatgataaat cgttcagggt ggtcagttac ctggtcactc ggatagaatt 2316421 gcggcccttc cggcaaatac gcttcgatct gcgcgagcaa ggtttcgatg ttatttcctt 2316481 ctaaagcaga aatcggaaca atttccttaa aaggataacg tttgcggtat tcgtcaatta 2316541 gcagaagcaa ttggtcggga tgaattttat caattttgtt tacgattaag aatacaggcg 2316601 tagacatcgt ctgcaatttc tcaatgatga attcgtcgcc cttcccgtag ccttcctcag 2316661 cattgatcat aaacaagatc aaatcgactt cttttaatgt attttgcgcc actttcatca 2316721 taaagtcccc aagtttatgc ttaggtttat gaatccctgg tgtgtcaata aaaatggttt 2316781 gtgatgtgcc tgtcgtcagt actccttgca ccttgtttct cgtcgtttgg ggcttatcgc 2316841 tcatgatcgc gattttttgt ccaatgactc tgttcaaaaa tgtagatttt cctacgtttg 2316901 gtcttccaat aatggataca aatcctgatt taaagctttc gttcgtcatg taaatcctcc 2316961 gatgaaaatg cgcctggcaa taattcttcc acagtcattt cttttatttg tccttgtaaa 2317021 ttagtcagta cgacaataac gtcttttgtg caaagctcag aaatcacctg tcggcaggct 2317081 ccgcacggag atactggtcc aggggtgtca gccgcaacgg ccagcatctg aaactctgta 2317141 tccccttcag aaacagcttt aaataaagcg gtacgctcgg cgcaattgca catgctgtat 2317201 gccgcgttct caatattgca gcctctgtac acttttccat ccttggtaag aagagcggct 2317261 cctacttgga atttggaata cggcgcatat gccatatcac gcgcttttaa agcttctgtt 2317321 attaattctt gtctgttcat gtgtacattc ctctcttacc tataatggta ccgctatcac 2317381 tttatatttt acataatcgc gcgctttttt tcacgcccat ttctaaaaat gtaaaataaa 2317441 tgtaagaatt ttcagccatt acagctttgg caaaaaaata agtaaaccaa tgatacacga 2317501 aatcacggca aaaacgcaaa cagccccggc ggcagcgtcc ttggccgctt tagcaagagg 2317561 gtgatgtttg tcagttatta aatcaaccgt atgttcaatg gctgtattta aaagttcaag 2317621 cgaaaacata ccacctatca aaaggaatat aatcatccac tcaataatgc tgagctctac 2317681 aaggaagccg caaatgagaa cagcgcaggc ggctgcggca tgaaattgga aattccgctc 2317741 cgtccgcgct gtttcccata tgccccggcc tgcatgcacg aagcttttga agaatcgatt 2317801 cagctcattt ctatgatctt ttgagtccat aagcgtccag caattccttt tgcttagtaa 2317861 acatctcctc ttcttcctct ttcgtcatat ggtcatatcc taaaaggtgc agaaatccgt 2317921 gtacagctag aaatccgagc tctcttttaa aagaatgatt atactcctct gcctgctctc 2317981 ttgtgcgatc ggcactgatg ataatatcac ctaaaaccgg aggcatttcg gcgcccacga 2318041 tttcgatctc gccttctccc tcttcttcaa gagcaaatga gatgacatct gtcggagcat 2318101 cctttccccg gtattctttg ttaatctgat gtatgtcatc attggaaaca atcgtgacag 2318161 aaacttcagc ctgatcctga acgccttcac gctcagcggc aaattgaagc agattttcta 2318221 cttctttgag catctcttct gagacgcttc ccgtttcatc aacgatatca atcagtaaac 2318281 tcatctattt caccttctta gtagcctccg gatattcaat ccgggagtgg aaaattcctt 2318341 ttaatgttgc acagagcgtt tttgcgattg tatccagctc tttaaatgtc aaatcgcatt 2318401 cactgaactg tccgtcctga agcttatcgg atataatacc ccggacaagc ttttcaattc 2318461 gttcaggatt tggattgtgc atggatctga cggccgcttc aacactgtcg gccactgata 2318521 taattgcggc ttcctttgac tgcggcttcg gtcccggata acggaactct tcctctgtaa 2318581 tctggtcgcc tttttccttc gctttatagt aaaaaaactt taaaagcgag gttccatgat 2318641 gctgctcagc aatatcgaca agctctttcg gaaatttata gcttctcagc atattcgcac 2318701 cgtctgtcgt atgcgagata ataatatttt tgctcaactg aggtgacagc ttgtcatgcg 2318761 gattgtcaat attcatttgg ttttcaataa aatattgcgg gcgctttgtt tttccgagat 2318821 cgtgataata tgcgccgact cttgcaagca aaccattagc cccaaccgct tcacaggctg 2318881 cctctgataa attggcaacc attacactgt gatgatatgt acctggtgtt tccgtcagta 2318941 ttttgcgcaa tagcggatgg ttaggattag acagctcgag cagcctcatg gtggataaaa 2319001 tgccaaagcc cgtctcaaaa aacggcatca gaccgatgat caatacagat gaagcaaacc 2319061 ccgacacaac ccccatgagc attaacgtgc cgatttcaag acccgacagc gcagtgttct 2319121 ggatcaataa taaggataga acgacaacca tattaataaa cgccacgaaa agtccggtct 2319181 gcaaaatctt tgatcttgca ttgtgttttc ctaaaaataa tacacctgaa atgccgctga 2319241 tcaaataata aatccctatg acataattga atgttcctgt cacaccctga ttaaacatca 2319301 tacttccgca aatcgcaaga atgatacttc ccaaaatggc aatgcgttca ttcatcagca 2319361 gtttgattaa gatggcgccg gccgcaatgg ggaccagata gccgatatta ttatactcca 2319421 tcttctgaaa caaactgaca acctccatga tcacaagcaa aagtgttgtg attatggaga 2319481 ataacagaat ggattggttt ttaaacttca gattttgttt ctgtttttca aaataatata 2319541 caagtgttgc aatgaaaagt ccgatcataa tcaatagccc gctgatcggt ttaaagagat 2319601 ttgagttatt taataacccg gtcagctcaa gtttcctgta cacttcccga tcaatgaggt 2319661 cattttcttc cacgagcact tgcccctgtt tgatttgaac ctgctggaca ttatctgagg 2319721 cttcctgccg ttttgcctct gttgctttcg gatcgaagac gtaattcgga ataatagcaa 2319781 aacgcccgat ttctgtcgcg gctcccaagt atttagacgg aatagaattg ctctttagct 2319841 ctttttctac cttatccttt gcatcagata gtttatccga agggatttca ctgctcatga 2319901 ccgtatttac cgcggtaatg accgtatctc tgacaaaaga aaagtcttca ctgtctgctt 2319961 tcagcaatgt cttgatggaa tcctccgata tagaatcatt cacatctgat gtcaatttgt 2320021 cctttacaga tttgaccatt gatttttccg atggtgattt actgccttct tccgatgatt 2320081 ttttcacttc actaatactg tcgaatattg atgacacaag gtcaatccga ttgtctgtat 2320141 attctttttt taatgtatat tgatcttcaa ccgcgtcctc agcggcttgc tttttttcct 2320201 ctgtggcttt ttgatcttct acggttgccg gagcgtaaat ggtcttgtcg ctgactgaaa 2320261 acaggtctaa atcaagtgtt tccggcttaa catgtacaaa gagcaaagca aacataatgg 2320321 cagccagcag aagatacagc agtacatgca tggagcgggc atttttaaaa ctgctccatt 2320381 tttttgagct gcttttggtc ttagccttct ttttcaacac aagaacctcc tcttgaaaca 2320441 tcaagcccat aagcaatcat aaaaatgacc cgataacgcg cgatcgggtc attcagcatt 2320501 aattttgctt atcgtatgct tcaataattt tcgcaacaag cggatgtctg accacgtctg 2320561 tctggtctag ctcaatcata gaaatgccgt ctattccttt cagcatctcc ttcgctactg 2320621 caagtcccga tttgacgcct ttcggcagat caatttggct aacgtcacct gtaatgatca 2320681 ttttagagcc aaaacccagt ctcgtcaaaa acattttcat ttgagcaggc gtggtattct 2320741 gtgcttcatc aagtataaca taagcatcat cgagcgtccg tcccctcata tatgcgagcg 2320801 gagcaatttc aatgatgcct ctttccatca gacgttctgt atgatctgcc ccaagcacat 2320861 catggagagc gtcatacagc gggcgcaaat aaggatctac tttttctttt aggtcacctg 2320921 ggagaaaacc aaggctttca ccggcttcca cggcaggtct tgttaaaatg atttttttga 2320981 tatgtccgtt ttttaaagca tggactgctt ttacgacagc caggtacgtt ttcccggttc 2321041 ccgccggacc aatgccgaat acaaggtcat tccgcttcat agcggccacg tattcccgct 2321101 gtcccattgt ttttacacgg attgatttgc cttttgcgtt ttttgtaatt tcttcttcat 2321161 acatgctttc aaagtattca agttcattct tctttgccat tttgatggcg taaatcacat 2321221 cacgttcaga gatctctatc cccttgcgaa ttaaagcgag gagcgatccc agcagcctgt 2321281 ctgcaatctg aaacgattca tcatcgcctg aaacataaat cgtctcgccg cgcgtaatga 2321341 tatttaaatt cagatctttc tccatcaatt tcaaaaaaga atcttggttc ccgaagagtg 2321401 aaagcgcctc gtccgggttt ttcagttttt gattcatcgc aagtaaatgt tctgtcattc 2321461 ttcagtctcc ctgacaatag gtgtggtttg aacgatatct tctataactt ggtagagaat 2321521 aatcaacttt actttaccat tctcaacagt ctggtgcaaa actttttcac ttttcacctc 2321581 gccgttttcg cctattttat cctctacatc ctgtttaccc aatttaatgc cttcttgaac 2321641 tgcttcttct tttgtatatt ttcgcaaagc ctcttcactt tctctcgttt gctctttgac 2321701 ataggataca gggagcttaa atccgagaaa atgaagcgaa tgcttttctt gttctgtttt 2321761 tggatgcttc aattcctctt ttttaaacgt catcccccag atcgggattg ccaaagaacc 2321821 aaaagaaagc ttgtgctttg tccttacttt gcccgtatag acgttaaata atgtttcaag 2321881 cgggactgtc acttctgatc tataccaggt ttctccataa atttctgctt ttgaggcgac 2321941 ttcctgctga tggtcttcgc tgccgatcag tcccgaaaca agcagctgtc ccttttcaac 2322001 atgatcgtgt atggcggcca tgggctgtcc tttttgcaca aacattctcg taatggttgc 2322061 tttctttttg gcgacaatat tgcgcgggct aacatatttt tctttttcgg gctcattttt 2322121 ctccacaact ttcatatgaa tggtcgtccc cttcagatca actccgaccc aagtgatatt 2322181 gtctattcca ttggttaatg atttctgtat tttttcgggc gacatcatta aaaactgcag 2322241 acggcccttt ttgacgccga tttcattaag atgctgcctc atttgatgtt ctgtttcagg 2322301 cttagcgcct gtcacatcaa ttttccacac catattggac agcaaaaaca aaagaatgaa 2322361 aaaaatcgca aaaccgatcg taaaccctat attcagcttt gatttcagca acaggaaggg 2322421 aaatcccttc cgattgataa atcgggcttt acatttaaat ttacttctta cccgccgaaa 2322481 ggcatgtaca tcctgaagct gtatatataa cgatacggct tctttctttt ttttgacatg 2322541 aaagaccgga atcccctgtc ttgtgcattc attaaggagc cgctcaatcc ctcttcccgt 2322601 caattcaagc tggaccttac ccgaaaaaaa agacagccat ttatttttca caacatttcc 2322661 ccctcggctt tatgactcaa catatcgaac gacatcaatc gtaccctcca aaagtatctc 2322721 ttccggaaga atcgccttga tgacaaaatt tttaccagat atgatgcact ggccctgctt 2322781 cagcatcagc cgcacttcat tctcactgaa aagcaaaagg cctctgtggt tttctatgta 2322841 gatatgaagt ctgccaacca ttgtaatcct cggcagatcc atcataacgt ccgggggaat 2322901 ttccaatgct cttgtcagcc aagctttcat acgattcttt ctttgcccca tacaaaaaga 2322961 accccctttc atctcatatg tatgatttga aaggaggttc taacacttta atttttacgg 2323021 gccgggcgca tcgtacggtg aggttttttc gcccgtggag gtccgaacac ctctcctaga 2323081 acgatcccct gtacgacggt gtctttattc acctgaagca ttttttgttt tgtgtatact 2323141 gttttttgtt tggcagcagc aagatctcgt tccagccctt tcaggtttct tgctgtttcc 2323201 ctgcgtcttt cttccgcttc ccgtcttgcc tgttccatac ggttagggat aggtgcaggg 2323261 gcatcttctt ttgactgctt cttttgagga gaagcagatt gcacgtgttg aggttttttt 2323321 cttttttggc tgttttgctt ttcttctttg ctctttttgc cgaaaatcgc agaaatgatt 2323381 ccgatgatcg ctgcaataat aagcggattg gtcagtaaat cttccatcag cgttctccct 2323441 tcttagagag attatgattt gcggtcttca tccgaagggt ctttcgtcag cttgccgaat 2323501 gaatcacgca tttctgtgtc agcatcgatg ttcttgatat tcatgtaatc catgacgcca 2323561 atattccctt cacgcaaagc ttctgccatc gcaagcggca cttccgcctc ggcttctact 2323621 actttcgcgc gcatttcttc tacgcgggca cgcatttcct gttcttgagc gacagccatc 2323681 gcacgtcgtt cttccgcttt tgcctgcgcg atgtttttat cagcctcggc ctgatcggtt 2323741 tgtaaaattg ccccgatgtt tttgccgata tctacatctg caatatcaat tgagagaatt 2323801 tcaaacgcag ttcctgagtc caatcctttt ccaaggactg tctgagaaat catgtcaggg 2323861 ttttcaagca cttttttatg attatcagat gaaccgattg tagaaacgat tccctcacct 2323921 acacgagcta caatggtttc ttcccctgct cccccgacga ggcgctcgat attcgctctt 2323981 actgtgattc tcgctttcgc tttcacttca atcccgtcca ttgcgacgcc ggcaatgaac 2324041 ggtgtttcaa tcaccttagg attaacgctc atttgaacag cttccaacac gtcccggcct 2324101 gcaagatcaa tggcagcaca gcgctcgaat gtgagttcaa tgttagctcg ctgagcggcg 2324161 ataagcgcgt tgacgactct gtcaacatta cctccagcca gatagtggct ttcaagctgg 2324221 tttgttccaa cattaagtcc cgctttatgc gctttaatca gcgggttaac aacccgattc 2324281 ggaatgacgc ggcgaagcct catcccaact agagtgaaaa tgctgatttt cactccggct 2324341 gccaaagctg aaatccaaag cattacaggc acaaatgtaa aaaatactgc caaaacaatg 2324401 atcgctactg cgacaattgc cagaatcata agtgttgacg gatccatata acttctcctc 2324461 gtttctattt aaatttctct cacgacaatg cgtgagcctt ctacttttat cacttttact 2324521 tttttatctt tttctgtaaa cgatccctcc gatacaacgt caaggcgttc atcatcaata 2324581 atcacggtac cggaaggacg cagcggtgta aaggttatac ccacttttcc cattaagtcc 2324641 gtgcgcgttt gatttgaaac gtagccgctc tccgtgtttg tagaatcatt taatatcaat 2324701 ttcttaaaga atttcatacg ctttcccaac acccttgtca gtaaaataaa agctgtaatc 2324761 gaaacagctg aggcgatcaa gagagaaacc gccatgacag tgaagctccc cgcggctaaa 2324821 aacaggctcg caataatcgc tcccaagccc agtaatccaa tgattcctcc gggaagaaaa 2324881 atctcaagca gaatgagaat cacccctgct ataaagagga gaaccgtctc atacccggca 2324941 aggccggctg caagatgccc gtaaaagaac agcaataacg caatgagtcc agccgttcca 2325001 gggaggccga cacccgggga aaaaagctct accgtcagac ctaaaaaagc gattgtcagc 2325061 agaataggga caatgaccgg attcgtcagc catcttgccg tcttttccgc aaagctctcc 2325121 tttgcatagc tgatctgcgc cttttcgaac ccaagcttct ttacgagcgt ggacaaattg 2325181 tcagcagtgc cttctgaata gcctacctca atcgccttgt ctgcgttaag tgtcagcaga 2325241 tctcccttag gcgcgccaac ttccttggca tctatatctg ggtcagccat tgcgagcgca 2325301 tattttggat cgcggttatt tttcactgcg gcatcttcca tctctgccag ccaaagtgat 2325361 tgagcttttt ggtcagcggc attgccttgg ccatcaacaa tcgcggcggc tcccattttt 2325421 ccgccaggcg ccatataaat gtgatctgct tgaagtgcaa tatatgcacc agcagacaac 2325481 gcgcgtttgt tgacatatgc agttacgggg atctcgcttt cggttatcaa atcggccata 2325541 tcaatagcag atttgaccaa tccccccggg gtattgatat caagaataat atggtctgca 2325601 tgtgcatcct ttgcgtcttg taacgaacgg gacaaaaacg aggcgagacc ctgttcgaca 2325661 tttttttcaa ccgggatcac ataaacagtt tgtttttctg cttttgcgtt cagctgtacg 2325721 cctaataaag aaagtaaaaa tatacccaaa agagcagcac ggaatccttt gatttgaagc 2325781 aagggcggtg tatccctcct tccttttata ataagtgcct tctcttcata cgtaacaaat 2325841 gtatcaaagg tttcattttt ttatgtataa aaaaagacat ctctcttaga aagatgtcct 2325901 tttctttgcc atttaagaca gttgactgct cacaagctta ttaattaaac ttccgtcagc 2325961 tttacctttt actttaggca taattgcccc catcactttg cccatgtccg cttttgagct 2326021 cgcaccgacc tccgcgatgg tttcatttac gattgtacgc agctcttctt ctgacagctg 2326081 ctcaggtaaa taaacttcta aaatgtccag ctctttttga actttatcta ctaaatctaa 2326141 acgattagcg tttgaaaatt cctggaggga gtctttacgt tgcttaagtt cacgagaaag 2326201 gacagtgagt tcctcatcct cggtcaaact gtctttctta agcttaattg cttcattttg 2326261 aagtgaagcc ttaaccattc gaacgacagt cagtttgtct ttctcacggt ttttcatata 2326321 cagcttcata tcctggttga gacgctcaag aagactcata aatccaccct cttttagaat 2326381 ttgcgttttc tagcagcttc agactttttc ttgcgcttta cgctaggttt ttcataaaat 2326441 tcacgctttc ttgcttcttg caaagtacct gtctttgata cactgcgttt gaagcgacga 2326501 agagcatctt caagcgattc gttttttcta acgaccgttt ttgacattct ctttccctcc 2326561 ctccgaatac accaatcgac tacctttaag ttacacatat aaacatgtac tttgacatta 2326621 taatataagc catcagtcag gtcaactaag tgagttcact tttccgtcat gagtgcgact 2326681 gcctgtctat ataatgaaag aaaggggttg gtgaatagga tgttaattct gattagcttt 2326741 actgctctta tattattctt tctcgcaggc atgaacatgc ttcgaaaggg cttaatttca 2326801 atggcgtact caaaaattga agaacgtttg cttttattta cagaccatcc gttaaaagcg 2326861 tttcttatca gtattgtatt tacggggata cttcagagca gctcagcctt tatggtcatt 2326921 gtcatcggct ttgtaagtgc gggcgttctt tcttttaagc ggacgatccc gatgattctg 2326981 gggacaaatg ttggctctac ttttacaact gaatttattg ctatcaaaat ggatattgtg 2327041 atttgggttc ttttaatagg aggtttattg ttttttctga ctggcaggta tcctttgaaa 2327101 cagctgggaa caagcttcct tggactgggc atcatcttct tttgcatcag cggattcagc 2327161 catcttgccg ggccgctgac aaagctgaaa acgggcgccg acgttctata ccatgttaac 2327221 gattcaaact ggtccgcttt gctcatcggc atggtgttaa ctgccatcat tcactccagt 2327281 tctgtctgta tcggcatttt gatgagtttt atgaatgaag ggattatcgg actgacacag 2327341 gcgatgagcg tcgtactcgg atcaaatatc gggacatgca ttacagctgt catggctgct 2327401 gtatccggcg gatatgcggc gaaacagaca gcatatgccc atgtggtatt taacgtgcta 2327461 ggggtggctc tagtattgcc ttttctgacc gcagcgaccg gctttgtaga gcagttatca 2327521 cctgatcccg cacaaaagat cgcgcatttc agccttttat ttaatgtggt gacagctctt 2327581 ttatttcttc cgcttacaaa cttgttttac cgattgattc accttcttat cccggctaaa 2327641 taaaaaaatc ggtacatttt aatgcaccga ttttttaggt taagaagaca aacgcatgtg 2327701 ttcagttatt tcatcctcaa ccacacggac aaactgtcct tcgttgtaag gataacctgc 2327761 ttttaggatt ttgactttta cgattttgcc gatcatatct tccgtacctt tgaaaacaac 2327821 cttcatataa ttgtctgtgt aaccgacaaa catattttct tcttctgttt ccttaaacgc 2327881 ttcctcaggg ataatctcaa gcacttcatt ttcatactga gaagcgtatt cttttgcaag 2327941 ctggtcagaa agagcaatca ggcggtgcac acgttcgttt ttcacgtttt catccacttg 2328001 gtcttccatt cgtgcagctg gtgttcctgt acgcttactg taagggaaaa catgcagctc 2328061 agagaattta tgttctttaa taaagttata ggtttccata aattcttctt ctgtttctcc 2328121 agggaacccg acgatgacat cagaagtaac agctaagcct ggcagtgctt ttttcaattt 2328181 atttaaacgg tctgcaaaga attccattgt atatttgcgt ctcatccgtt taagcactgt 2328241 gtttgatccg gattggatag gaatatgcaa atgattcact atcttatctg agcggtctaa 2328301 gacctcgatc acttcgtcag tgatttggct ggcttcgatt gaagaaattc tgatccgttt 2328361 cacgccttcc acacgggtgt ctaattcgct caaaagcttc gcgaagttgt aatctttcat 2328421 atcttcgccg tagccgcctg tatgaatacc cgtaagaaca atttccttat atccggcatc 2328481 gacaagctgc tgcgcttgtt taatgacttc ttcagggtcg cgggagcgga gcaggcctct 2328541 cgcccacgga atgatacaga atgtgcagaa attattgcag ccctcctgta ttttcaatga 2328601 cgctcttgtg cggtccgtga aagcaggcac atcaagctct tcatatactc ttgctttcat 2328661 gatgttgctg acgccattaa tcggctggcg ttcttctcgg tattggtcaa tgtagccaag 2328721 cattttttca cggtcctgtg ttccgactac aatgtcgaca ccggggatcg ccataatctc 2328781 agcaggtgag gtttgcgcgt agcagcctgt gacacagatg acaccgtcag gattttgacg 2328841 aatggcgcgt ctgatcactt ggcggctttt tttatctccc gtatttgtaa ccgtacatgt 2328901 attaatgaca tatacatcag ctgtttgttc aaagtctctt ctttcatagc ccgcttcttt 2328961 gaaaagctgc cagattgctt ctgtttcata atggttgact ttacagccaa gcgtatggaa 2329021 agcaacagtt gccattactg atcacctctt aataactctg tttgataaga aatcgcactc 2329081 aacgcgtata gcggagcggt ttctgtcctt aaaattctcg gtccaaggcc gcacgtcaca 2329141 ccgtcttgct ctgtgagccg ttcaacctcc gcttctgtta aaccgccttc gggaccaaat 2329201 acgatcaata gagatgatcc tttcggaagg ctgcttacaa tcgcgctgaa tgcgcttatt 2329261 tccccttgct tcgatgactc ctcgtatgca acgacacatt tatcgaaatc ctgcatcctt 2329321 tgaagaagct gctgaaaaga atggacatcc atcactcgcg gcacttcgtt acggtacgat 2329381 tgctcagccg cttccttcgc aattttcgtc catctttccc gctttttctt tgcctttttg 2329441 tcatccagct tgacaacaga acgcgcggct tggaaaggaa taaaggcatg agctccgagc 2329501 tcagtcccct tttggataat ccattcaagc ttatctcctt tcggaaggcc gctcgcaata 2329561 tagaccttta tcggaagctc tctgttttca ttcgtccatt ctatcacaag gcaggacact 2329621 ttatctttgg aaacagattg aagttcacat tttgcctcga agccgtcttg agagcagcag 2329681 ataatctgat ctccctcatt cattctcatc acgttcacaa tatgatgaac ttcttcgccg 2329741 gtaatcgaaa aagtcggcgc ttcctctatt tgctgcttcg tgagctcgat aaaatatcgt 2329801 tgcatacgct gtgacaccta ctaactgtta ttttttcgca ataatgctga cccaatcttc 2329861 cattgaaagg atttctacaa tggtaaagcc agcttgttcc agtgcttctt ttacttcttg 2329921 ttttttatga ccgatgattc ctgacgtaat aaagtgaccg ccttctttta acaggctgta 2329981 cgcttgtgaa gtaaagcgaa gaatgacttc agccaaaatg ttggccacaa tcacatcatg 2330041 ttccccttca atcccgtcta acaaattgtt ttgcttcact tgagcaatat cgctgacttt 2330101 gttcagcttg agattgaggc gtgcactttc tacagccacg ggatcaagat cgtaggcatg 2330161 aaccgattca gcctcaagca ttgcagccgc aatacttaaa attcccgaac cagtgccgac 2330221 atcaatcacc ttatcaccct tttgcacaaa gcgttcaagc gcctgaatgc agagtacggt 2330281 tgtcggatgt gtccctgtgc cgaaagccat tcccgggtcc atttcaataa tcagttcatc 2330341 agtatggacc ggcgtatatt cctcccacgt cggcacaatt gtaaactttt cagaaatttt 2330401 cacaggatga taatactttt tccaggcagt cgcccactct tcttcattta cttcagaaat 2330461 agtgatgtgg tttctgccca aatcaatatt gtaaagaagg agattattaa tcgtttcttt 2330521 gatgccgtct acagtttcgc ccagaaaact gttaaccggc agatatgctt tgacaatgac 2330581 accctcatct gggtaatcat tggggtcgag ctggtagatt tccccgtaca cattctcacg 2330641 ttctttaatt aaatcaagcg ggtcctctat cacaacccca cttgcaccag cttcatgcaa 2330701 tatatttgag ataggttcga ccgcttcatg tgttgtgtga atgcttaatt cggaccattt 2330761 caaaactacc aactcctcat ccaataatta atcgccttta aacgcgcgtt ttaccttgtc 2330821 aaagaaactc atttcctgtt cgtcaggcag gtttccgctg acttcggcaa attcgcggat 2330881 aatgtctttt tgtttatcag tcagatttgt cggcgtaacg acgcggacga cgatatgctg 2330941 gtcaccctgt ccatagcctc tgacattttg aacgcctttg cctcttaatc tgaatttcgt 2331001 tcctgtttgt gtaccggccg gaattttcaa tttcactttt ccatgcagcg tcggcacttc 2331061 tacctcatct ccaagagcag cctgagcaaa cgttaacggc atttcacagt aaatatcatc 2331121 gccgtcacgc tcgaagaact cgtgtgcgcg tacatggaac acgacaaata aatccccggc 2331181 agggccgccg tttattcctg gttcaccctg tcccgagaga cgaagctgct gcccgtcatc 2331241 tacaccggct ggaattgtca cattgatttt cttgcgtttt ttgatttttc ctttgccgcc 2331301 gcagtccgca catttgtttt taatgatttt gcctgtacct tcacagtggt ggcagacccg 2331361 tctgttaacg acttttccaa acggtgtatt ttgctccacg tttaactggc cggagcctcc 2331421 gcagtgggag catgtttctg gatttgttcc aggtttcgca cctgagcctt tacatgtttc 2331481 gcacgtttcc tcgcggggaa tttcgatggt tgtttcttta ccgaaagccg catcctcaaa 2331541 cgacagggtc atcgtatact gtaaatcagc accctggcgc ggagcgtttg gatctcttcg 2331601 tcttgtgcct ccgccgaata tacttgagaa aatatcatcg aaaccaaaac cgccgaaatc 2331661 gccgccgcca aaacctccgc cgccgaagcc ttggttaggg tcagtgtgac caaattgatc 2331721 gtaatgcgca cgtttttggt catctgacag cgtttcgtat gcttctttta cctctttaaa 2331781 tttttcatct gatccggctt ctttgttaat atcaggatga tatttttttg acagcttccg 2331841 ataagctttt ttaatttcat cctttgaagc gctcttactt actcccagca cttcatagta 2331901 atcacgctta ctcatctcgc ttcactctcc cgaatttctc acataaatta gattgtatca 2331961 ttttgaatta tgatttttca attcctttta tcccgggcaa gaaaaaaagt caaagccaag 2332021 agatgcctga ctttgacttt ctaatcattg aatcagatta tgaaatgtgt tcttttcggt 2332081 cagctccgga agcggggctg acactaaaaa gaacttattt tttgttttgg tcgtcgttta 2332141 cttcttcgta ttcagcgtcg acaacgttgt catccgcttt gccttcagcg tttgctccgc 2332201 cttgagcttg ctgtgcttta gcagcttctt cataaagctt catagaaagc tcttgaacga 2332261 ttgtttgaag ctcatctttt ttcgctttga tctcttcaaa ttcgtttttc tcaatcgctg 2332321 cttttaaagc gtctttggca tcgttggctt ttttcacttg ttcttcgtcc actttgcctt 2332381 caagatcttt taatgttttc tcagtttgga aaacaagctg atctgcttcg ttgcggactt 2332441 cgatttcttc ttttttcttc gcatcagcgt cagcattttc ttccgcttct tttaccatgc 2332501 gttcgatctc ttcatctgag agacctgaag aagatttgat tgtaatgttt tgttcttttc 2332561 ctgtgcctaa gtcttttgct cttacgttta cgataccgtt tttgtcaata tcgaaagaaa 2332621 cttcgatttg aggcacgccg cgcggtgctg gcgggatatc agtaagctgg aagcggccga 2332681 gtgttttgtt gtcggcagac attgggcgct caccttgaag aacatggata tcaacagctg 2332741 tttggttatc agcagcagtt gagaacactt gagatttgct tgttgggatc gtcgtgttgc 2332801 ggtcgatcag ttttgtaaac acaccgccca ttgtttcgat accgagagaa agcggtgtaa 2332861 cgtcaagaag aacaacatct tttacgtcac ctgtgataac gccgccctga atcgcagcac 2332921 caagcgctac aacttcatcc gggtttacgc ctttatgcgc ttcttttcca gtttcttttt 2332981 tgattgcttc ttgtacggca gggatacgag ttgatccgcc gacaaggatg actttgtcga 2333041 tttcgcttgc agaaagtcct gcatcttgaa gcgcttgacg gacaggaccc attgtgcgct 2333101 ctactaaatg agaagaaagc tcttcgaatt tagcgcgagt taatgtaagt tcaaggtgaa 2333161 gcggtcctgc ttctccagct gtgataaacg gtaaagaaat ttgcgtagaa gatacgccgg 2333221 aaagatcttt tttcgctttt tcagctgcgt ctttcaaacg ctgaagcgcc attttgtctt 2333281 ttgacaaatc aatgccgttt tcttttttga attcagacac cagatgatcg atgataactt 2333341 ggtcaaaatc gtccccaccc agacggttgt cgccggcagt tgaacgaact tcgaatacac 2333401 cgtcgccaag ctcaaggatg gaaacgtcga atgtaccgcc gccaaggtcg tatactagga 2333461 tcgtttgatc ttcatctgtt ttatcaagtc cgtatgcaag cgctgctgca gtcggctcgt 2333521 tgatgatacg ttctacttca agacctgcaa ttttaccagc gtcttttgtt gcttgacgct 2333581 cagcatcgtt aaagtatgca ggaactgtga taactgcttt tgatactgtt tcgccaagat 2333641 agctttcagc gtatgattta aggtgttgaa ggatgatagc agacacttct tgtggagtgt 2333701 aatcctttcc ttcaatttca actttataat cagtacccat atgacgtttg atagacataa 2333761 ttgtgttagg gtttgtaata gattggcgtt tagccacttc ccctacttga cgttcgccgt 2333821 ttttaaatgc aacaactgat ggcgttgtgc ggtttccttc agcgttagca ataactttag 2333881 gctcgccgcc ttcaagcact gccacacatg agtttgttgt tcctaagtcg attccgataa 2333941 ctttactcac ttgaataacc tcctgctatg taattattga ttcactttga ccatggaagg 2334001 gcgaatgacg cgatccttca gcttatagcc tttttgcatt tcctcaacaa caatgttgga 2334061 gccgtagttt tcgtcttcag cctgcataac agcttggtgc agattaggat caaattcctg 2334121 ccctacagct tcgatggctt cgacgccttc ttttttcaag gcttctacga gctgacggtg 2334181 gaccatttcc attccctgga gcaaactttt cgtctgttca ttgtcggctt caacctgaag 2334241 cgctcgttca aaactgtcaa gagccggcag caaatcagtc acgatatttt gagaacggta 2334301 tttttgggac gcttccatct ctaaacggct gcgtcgttta tagttttcaa agtctgcttg 2334361 aacacgcaaa agtttgtttt ctttttcctc aagcaaacct tgcaattcgt taatttggtt 2334421 ttgaagaagt tcgctttcat ttgtttcttc ctgctgttca tcagcggcag cttgttcttc 2334481 aatgatttct tgctcttctg tttcgttttg ttcaacggtt tgtttttctt ctgacattgt 2334541 gttcacctcc ctcaaagtgt aaggagaagg acaggtgctg cccttcgata aaatttgcca 2334601 aaattccctt attcatcata cagacttgtt aatgcttttg acaagtccga agtcacatgc 2334661 tgaagcaggc tgacaaccct ggaataattc atgcgggtcg ggccgataat cgcaattgag 2334721 ccgatctgct tctggtctac ggaataagaa gccgtaatca gactgcaatt ttccatctct 2334781 tcatagtcgt tttcttttcc gattttaatc gaaattcccg tgtgcgggga ttgaaccagc 2334841 tttaaaacat cctgttcttt ctcaattaat gaaagcagcg accgaactcg ggtgatatca 2334901 tggaactcag gctggttcag catattgatt ttcccgccaa aaaacaactt ttcaacgtga 2334961 tttgtggaat gaaaggttga acgaagcgcg tcgagtatat tgtcatagtt tttaatgtgc 2335021 tgtcttaggt acatgacaac ttctttaaat atgcgctcat tcagttcatc cattggaacg 2335081 ccgcttaaac ggtcgttcag tatatttacc agtttttcaa tatcagacag atccattttg 2335141 gtcggaaagt taatcgtttt gttttccaca tgccccgtat tggtaacgag aatcgctacc 2335201 gccatatcag gctgaatcgg aatgatttga atctgtttaa ggtaattctc actcaacttc 2335261 ggcccgagta cgatggatgt gtaattcgtc agatcggaca aaatttgcgc tgatttttga 2335321 actgtcttct ccagctcgaa aattttctct ttgaagatcg agtggatttg gtccaggtcg 2335381 cttttcgtca atttgacggg tgacagcaaa tggtcaacat agtaccgata ccctttttct 2335441 gacggaacac gtcctgagga tgaatgggtt ttttcaataa agcccaattc ctccaagtca 2335501 gccatctcgt ttcttattgt tgcagagcta aatgtgattt catctttttt cgaaagagtt 2335561 cttgatccca ccggctgtgc cgatttaata aaatcgttga ttataacctg aaggatcagc 2335621 agctgacgat ttgttaacat catcatcacc tctgttagca ctctcaataa gcgagtgcta 2335681 attctataac aaaagtatca aaccacaaga aaaatgtcaa ttataactca cccaaaaaag 2335741 cgccaaaaac ttcattgcct aataatttcc cttgatgagt caaataaacg gcagactccg 2335801 aattgtgaat cagccctttt tcagcgaggt cttttaacac gcttgggaaa agtccatcca 2335861 gggaacggcc gtatttttct gcgaatcgtt ttttgctgac accggctgtt tttctcaaac 2335921 ctaaaaacat ttcttcctca atctgttctt ctgttgtcac ttcatgtgta tctctgtacg 2335981 gaaaaccctt ttcagctatc aggtcaatgt aatgcttaac aggtccgacg ttcactgttc 2336041 gtgtgccgcc aatatatccg tgagcgccag ctccgaaacc gaaatattgt tcgttgctcc 2336101 aatacgttag attgtgctta gattccatgc ctgccttagc aaagttgctg atttcatatt 2336161 gatgaatgcc gtgagcttcc atcttgctca tcactatttc atacatttca gcttcctgct 2336221 cctgcggcgg aagatgaagc cgcccttttt gcatcaaatt ataaaatacc gttttcggtt 2336281 ctacaataag ggagtaaacg gaataatgct cagcgtccaa tgataaagca gtgtttatgg 2336341 aatgttccag atgcttgagg gtttgccccg gaagcccgaa catgagatca agactgatat 2336401 tctcaaaacc gatttcccgc gctctttcaa aagaggtgaa tacatctttt tgcttgtgca 2336461 ctcggccgat tttttctaac agatcgtctt cgaacgtttg cacaccaaag ctaaggcgat 2336521 ttacgcctgc ttcttttaat atttttaatt tctctgcgga caaatcgtcc ggattcgctt 2336581 caaccgcaaa ttccgataag tcgcttgagg gctttagcac gcggttgatc atatccatca 2336641 gctttttaag ctgttcctca gacagggagg tcggcgtgcc tcctccgata aagattgttt 2336701 tgagatcagg ctgcccggtt tttgctattg tatttatcat ttcctgttcg agtgcgttta 2336761 aatactcgtc gactggctga ctttgaataa aatatttatt gaaatcgcag tagtggcaaa 2336821 tatgctcaca aaatgggata tggatataag ctgatttcaa cggattcacc ttctttacag 2336881 aaagaagccg cagtacaaga ctgcggcggc ttctattgtt ttttcggact gtcgtccatt 2336941 ttcagaactg ccataaatgc ttcttgcggc acttcaactg agccgacctg cttcatacgg 2337001 cgctttcctt ctttttgttt ttcaagaagt ttccgtttac gcgagatgtc ccctccgtaa 2337061 catttagcca atacgttttt acgcattgct tttatggtgg agcgggccac gattttctgg 2337121 ccgattgcgg cttgtaccgg aacttcaaac tgctggcgcg gaatgagttc tttcagtttt 2337181 tcaacgatca cttttccccg ttcatatgcg taatcacgat gcacgataaa ggaaagggca 2337241 tcgatttttt caccattcag cataatgtcc attttcacaa gcttggacgg tttgtagccg 2337301 atcagttcat aatcaaagga cgcatagcct ttagtgcttg atttcagctg atcaaaaaac 2337361 tcatatacga tttccgctaa tggcatatca taaatgatgc tgacacggtt tgcgtctaaa 2337421 tactgcatat caatgaaatt gccgcgtttt ccttggcaaa gctccattac agcgccgaca 2337481 tagtcattcg gcaccatcat cgtcgctttt acgtatggct cctcaaccct ttcgatcttt 2337541 tgaggatccg gcatgttgga cgggttgtcg acaacgacct tttcgccgtc tgtcatatac 2337601 acgtcataga taacgcttgg cgctgtcgta atcaggtcga tgttgaactc acgctcaatt 2337661 cgctcctgaa tgatctccat gtgaagcatg cctaaaaatc cgcagcggaa cccgaatcca 2337721 agcgcttgcg aagtttccgc ttcatattga agggaggaat cattcagctc aagcttttca 2337781 agagcttccc ttaaatcatt atacttcgct gtatcaatcg gatacaaacc acagtacacc 2337841 atcgggttta gcttgcggta tcccggcagc gcttcttctg caggattggc agcgctcgtt 2337901 attgtatcac cgacacgtgt gtcaccaaca tttttgattg aggcagtcag gaagcctaca 2337961 tcaccgaccg tcagttcatt tgtcggagtt gctttcggcg tgaacacgcc cacctctgtt 2338021 acttcgaatt ctttgccggt tgccatcatt ttgatttttt gtcccggctt taccgttcct 2338081 tcaacgactc tgatataagc cacgacaccg cggtaggcgt cataaagcga gtcgaagatc 2338141 agcgctttga gcggcgcctc cggatctccg gtcggagctg gcaccttttc tacgatttgt 2338201 tctaaaatct cctcaatccc gataccggct tttgctgaag caagcacggc ttctgatgcg 2338261 tcaaggccga taacgtcttc tacctcttgg cgcacacgtt cgggctcggc gctcggaagg 2338321 tcgattttat tgatgaccgg aaggatttca agatcgttgt caagcgctaa gtagacattg 2338381 gcgagcgtct gcgcttcaat cccctgggct gcatccacga caagaatcgc tccctcgcag 2338441 gcagcaaggc ttcgggatac ttcatacgtg aagtcgacgt gtcccggcgt atcgattaga 2338501 tgaaagatat attcttctcc gtcttttgct ttatatttaa gctgaacaga gtttaattta 2338561 atggttatgc cccgctcacg ttcaagatcc atagaatcga gcaattgttc tttcatttct 2338621 cgttgagtga ttgccgacgt tttttctaaa atacgatccg ctaaggtcga ttttccgtgg 2338681 tcaatatggg caatgataga gaaattccgt attctcgatt gcctctctaa acgcttttct 2338741 ttatctgtca caatctatca ctcctactat taaacgcaaa atacactagc ttagattata 2338801 tcaataggat tgtaaagatt caatgtaaaa caagaaagag aaaagttccc tatcatatct 2338861 gggttgcttt tctctttcac gtacttattg attcatatcc cgtatccatt catacattga 2338921 ctgggcagta ttggttacgg tgtccgaaag cgcttttccg gcttttgaaa acatattgaa 2338981 tgtctccacc ttttccagct ctttttgttt ttctactaaa tcttttgccg tgactgtttc 2339041 tcctaggatt gaggcttctt tttcattatc ttttccgtcg gtgagcgtaa acgccccctt 2339101 cagtgaaggg tcatgatagc ctttcatact cagcatcccg tggtttgcct gctgcatgcc 2339161 gaacagaacg cctaaaaaca tgatcgtgac aagcagtaag cactttccaa agtatgcaat 2339221 caaatcaacc acctatttct tattgttttt tcgtctcccc gctcgctgcg ttgacctttt 2339281 cagcatccca gtacatttcg ctgaatacgt ccgcggccgc gttagccgca cgctgcagct 2339341 cttcgagatt attatccact ccgccaaact cgagcaaaag cgctctatcg gttaaatcct 2339401 gattgtaaac accattatcg cctggcgagc ctttggaaaa gacacctgtg ctaagtccgg 2339461 ggtatttttt ctccatcagt ttatgaagct cactcgcaat tttatagttt tcttcgaagt 2339521 ttttgctttt tttcccgacg acaaaggcta ccctggcata gcttttccct ttaatcgttg 2339581 cggttgtgtc ttttttgcgc cgagagtctc tgtggatgtc aatgatatat tgcagatttt 2339641 tgtttgaagc gagggcgtct ttcacgaccg gccttgattc atcataggac ctggcatagt 2339701 ttaagccttt tttattcaat tttgactgta tatcggtttt attcactgtg gctccgattc 2339761 cctgggattc aagcgcttgt ccgaacatat ctcctacaag cgtgacattg gctttagaat 2339821 ggcgcgccat gtcaggatcg gtctcgcctt ttaatagagg gagatatgat tccgtattgt 2339881 gcgtgtgata gataaacacg acctttttat cacctgttgt ttgtttcggc ggatcttttt 2339941 gcgcattatc tgattgcgtt tgctgttttt caatctctgc caaattcgct tctctttctt 2340001 cctccatcac cttagacggc ggcggcgatt ccgcaggcat attcgtataa tccgttcctt 2340061 gtccagctaa caaaatctcg gtatcaaatt gtgcaaatcc tggcagctcc cgaccgagaa 2340121 agctccgcgg atcttcgagg ttaatgctcg tcgccagctt taaagaaaga cgagaaagat 2340181 gaaatgagct gtctgtttga gagaggtcag aagcgaaata atggttttcc atctgcagca 2340241 aatgtgcaaa tacgtcaccc ggcaattctt cagcaatccc ataaaaagag tcagacgacg 2340301 gcctaagttc cggccggaga gacgtcagca caccggatag aacaaaaatc acgataaggc 2340361 ttacgataaa tagaaagatg gcttttaccg ctttccctcc atttaccgca acaacaatct 2340421 gtctgtttct gcgtttattt ctcattgaat ccctccagcg cttgtctagt aattactcta 2340481 tgaacaagct agaggaagta gaactgttta gtgattgtag gagcctttgt tttcttgtga 2340541 cactttttca tgaagcgctg tgtttaatcc gttcgctaaa acatttgcca tatcgtcgat 2340601 aaatgaatcg acttccttcg gtgtaaccat taagttgtgc cctaaaggcg aaagcacctc 2340661 gtgaatgagc tgccgttttt catcttcttg aagggttccg acaataccta ggaacgattg 2340721 gcgctgcttt tgatcgggaa gatcgtcttc agtgagcact ttctttttcc caaacgtcat 2340781 gcctgccgga acaagcgatc ttgatggcct gttatccttc atttctctgc caaaatgttt 2340841 taatatgtag tccaccgtgt cgctggcaat tgtcacggca tcaactactg tcggaacacc 2340901 gatagcaatc accggaacac caagcgtgtc tttgcttaaa tcttttcgtt tattccccac 2340961 tccagacccc gggtgaatgc ctgtatccga tatttgaatg gttgtgttga ccctttccac 2341021 cgcccgcgcc gccaacgcat caatggcgat gacaaaatca ggcttcgatt gctcaatcac 2341081 acctttaata atgtcacttg tttcgattcc tgttatcccc attacacccg gtgcaaaagc 2341141 actgacaggc ctgtaaccct cctgtacgtt ttccggctga agcttaaaca agtgccttgt 2341201 taccaacaga ttttctactg ccatcggtcc aagcgcatca ggtgtcacgt tccagttgcc 2341261 gagcccaacg atcaaacagc tcgcatcttt tgagatatta aggttttcaa gaaaagctga 2341321 gaattcctcc gcaaagacag cagagacctt ctcctgcatt tccgaatcat tctccctgat 2341381 tccctgtgct tcaagcgtta aatagcgccc ttcttttttt cccgaaagct ctgcgccttc 2341441 ctttgtaaca tcaactgtgc ggattttaat gccgccgtga tcacgctctt tttcaataaa 2341501 gcctttaatt tcttttgtcg gcacagcctg ctgattggcc attgcttcct tcgtttccac 2341561 tgccaaatcg gtccgtatca aatactgatt cacatccagc tcactctttt tcatacaggg 2341621 gcctccttca cattaagtac ctatattgtt gccatttgct gaataaatca tgctaaaaag 2341681 agaaccttca atgaaaaata ctttacattt atattgcaat ctaaaggtgt gtttgataga 2341741 atacaatttg ttctattgtg aagaagattt aaccttaaga cactgtgcta caggttgtat 2341801 cttaggaggt gaaacacatg ccaaacatta aatcagcgat taaacgtaca aaaacaaaca 2341861 acgaacgccg cgttcataac gcgacaatca aatctgctat gcgtactgca atcaaacaag 2341921 ttgaagcttc tgttgccaac aacgaagctg acaaagcgaa aactgctctt actgaagcag 2341981 ctaaacgtat tgataaagca gtgaaaacag gtcttgtaca caaaaatacc gcagctcgat 2342041 acaaatcaag actagcgaaa aaagtgaacg gactttctgc ataatataaa aacgatcctc 2342101 aataatgggg atcgtttttt tcatttcttt ttaacagctg taaaaggaac agttcgagca 2342161 ggagctgctt gtcctttttc ccggttttca tctcatagtc catgacggca agctgttcaa 2342221 taattaaacg gagctcctcc tctgaaaaaa gccttgcttg atccatcgcc agctttaccc 2342281 gaaatgggtg aacttttaga ttagaagcga tttgtttttg tccgtatccc tgttccgcga 2342341 agtacttcgt ctgcagaatc agccggaact gattcgaaat aagcgccata attttgatcg 2342401 gttcttcatt ttgttttagc aaatcataaa aaatttgcag actctctgtt cgttttcggt 2342461 tgacgatttt attgatcagc tcaaaaatat tttgttcaag gcttctagca acaagcattt 2342521 ttacatcatc cagcgtaatt tcttcacgat ctccaataaa cgtgcagagc ttttgaatct 2342581 cctgaaaaat cgatgacaga tgaccgttca caagcagaac caaatgctcc gccgcttccg 2342641 tgccgattgt tttctgctct gtttttgcaa ggttgacagt aaagtctgtc gtttcctttg 2342701 catttaattc cttcgcctcc atcataaacg cgtgcttctt taacgctttc gtcagctttt 2342761 ttcgctcatc aagcttttca tacggagcaa gcaggacaaa gactgtgtaa ggcgcaggtg 2342821 attgtatata tgattcaagc gcactgacgt tgtgctcaat tttttctttt ttcttttcac 2342881 ctgttaaaaa atatggattt ttcacaatga caagacgccg ctcccccata aacggaaacg 2342941 tttcagcatc tgcaatcgct tgatccagcg ggtcctcttc cagatcaaaa acggacagat 2343001 tgaaatcctt tgtctcctga tcaacgaccg tctgtctgat cctgctgacg gtttcttgca 2343061 gcagatatgt ctcttttccg tataaacaat aaaccggatg gacctctcct tttttcaggc 2343121 ttttccacac atcaaatacc attgttgtac gacttcctct ctttcatcat ccccttctat 2343181 cctaaattga gtttgcaaaa tagtaaagag gaagcctgac tgctgcttcc ccatttatat 2343241 taaacgcctg ttcgcaagcc cccgggacag cttgtaaaaa ggcgataatc accagaacag 2343301 aaaacgttac cttagcttct agatttttca aaacaattcc attatactta agtcagtcag 2343361 gagggataaa gttgaatgat tttgaaaaaa acgttcaaag caaacgaaat gatgctgtag 2343421 attcagctgt tggttttgtt gtgtccttcg gatttttcgc cttcttgttt gtcatggcaa 2343481 cggttattca cctagttggt tcataacagc gactgcccgg gctgctgatt tctcggcagt 2343541 cttttttagt tcgtctctgt tatatctgat gtatcatatg gaggatagac agaaaaggtt 2343601 ccaactctgt ttttgtatct atattggatc gttccgtttt gatctgttcg cagcacgcgg 2343661 atagaatgtc tctgtaatag ttgcagaact ttttgatgag gatgatggta ccgattgttt 2343721 ttcccggctg agataatggc cgttttcggc tgaagctgtt ggatgaattc ttcaccggta 2343781 gagcctttgc tcccatggtg ccccaccttt aacacatctg cttttatatt cggaaacacg 2343841 ttcatcacct cttgttcccc ttctttctcc agatcacccg tcaagatcca gctcataccg 2343901 cccgtctcca tccacagaac gagagatgaa ttatttttgc ttgccggatc aggtgcttcc 2343961 ggtgacagta catggaactg caaatccttt atttgcaaca catcgcctcg cttcacctct 2344021 tcaattgcca ctccctcttc cctggctgcc tgcagcactt tctcatcttt aggttcagaa 2344081 acgaaccctt tcggaatcac gaggcgcttt actttatgat gcttcagcag aatctccgcc 2344141 tctccgatat gatcttggtc agcgtgcgtc agaattaaag cgtcaagctg cttgattccc 2344201 ttagcagtta aaaacggaat cagcaccttt tcccccagtg aaaacggatg ctgtttttcg 2344261 cgccaaggct ctgacgagta agacaaagtg ccgccggtat caattaagac acgaccccgc 2344321 tgatgcggag cacctacaaa catgctgtca ccctgtccaa tatctatcat atccacttct 2344381 ccttcggaac taagacacgg atatataaag agcagaaaca tcaccgtgca gcaaatgcct 2344441 ccggttacca tcaactgcga caaggagcgt ttttcaatcg ccataagcaa taggatgatc 2344501 gtgactgtga ataaaaaaag caaaacaggt gcaggatgtg cgatcataat cgtgaacaca 2344561 tcaacatctg caatgtttgt gattaaccta ttgatccagc ttatcaataa atcaaaccag 2344621 ctgaaaaaca atctcccaaa cgaagcggaa agacttaata gaagaacacc tgctacagct 2344681 cccggcaaaa tacagaaggt ataaaatggt accatcaaca tattcatcgg tacgctgatg 2344741 atagaaaact gatgaaaatg atataggaga atcggaagcg agcccagctg agcgatgagt 2344801 gatacaattg tcagctgccc caaggaggtt ttaacctgct gaaaaataga agaggataga 2344861 attaaagaaa aactgacggc gaacgatagc tgaaaaccgg cttcaaagag atgataagga 2344921 ttgaagagca gaaggacgat gtacgaaagg caaattgcag ttgcagagcg gacacgccat 2344981 ttgacaagac ttccagctaa gtaaacaccc gacatgagag cggcgcgtag cactgaagga 2345041 gcagcgccgg tcaacatcac atagagcggc agaaataaca gcaacagaat tgacgccttt 2345101 tctctagtta taccaaggcg gatcatgata taaaacaaac ctgctgtcaa aatccccacg 2345161 tggagtcctg atattgccaa gagatggaca acaccaagct tttgatacgc ggtaagcact 2345221 tcatcctcca cgtaaaatct gtcaccaact gtaagtgcct gtacaatccc tgtcgaatca 2345281 ggaggcagaa ggctgtttgt gaatgatatg atatgttttc tcaagctgag caccttgtac 2345341 ttgaaatttt caggttcgct gcagttttgg atagacgtga cagagtagtt ccaatgaata 2345401 tgctgccgat aaagatactc gttataatca aatgcacccg gcacagttgc gtgattcggt 2345461 tcttccaatg taccagtcaa ctcacatgac attcctggtt ctatgtataa cagctgttct 2345521 ttttcaccag cagactgaat gcgatacgca gcagcccatt tttccttatc aggtgtctca 2345581 accatcatag acatacggtc gccgtcaatt ttgggaatag tgtcaatcac tgccttgaat 2345641 tgataggttc cctgccgata ggaagagaca ttctgagaat ctgtgactgc atacagtaca 2345701 aaaaacaata taaaagagaa gaaacaaaca ataataagaa aagcgtgcct cgttttgatt 2345761 aaaatgatga ggagaaagag gatgaaaaga aaaatagcgg ggaaataagc ggcggcagta 2345821 attccagccg ttgccgaagc tgccgccata ggcaataata agcgcgaatt acgcattcat 2345881 cacacgtagc tcgtgaaaag tgtattcgcc tgttcatgta tctttttcaa ttcttcctcc 2345941 gctaaaccgg catcagccaa tttccctatt agacccgcta caaatgaaag cttttctctg 2346001 tttttcagat caacgatcat ttcatcgagt tcaacctgtt caacagttac acccgcctgt 2346061 tcaaataatt cctgcgcata cggatgtgtt ttgtaatcct cagcataata aaccgttttg 2346121 ataccagctt gaataataga tttgcagcat tgaatgcacg gataatgcgt cacataaatc 2346181 tcggctccat cagtcggcac cccaaactta gagcattgaa gaatcgcatt catttcagcg 2346241 tgaatggttc ttgcgcaatg atcatctatc attaagcatc cttcatctgc acaatgtacg 2346301 ccgcccgcga ttgacccatt gtagcctcct gctatcatgc gtttgtctct gactatagta 2346361 gcgccgacag ataatctcgg acatgtgctg cgcagcgcca ataaatggct ttgagccata 2346421 aagtattgat tccatgaaat tcgttccacg ttgttccctc caaatgttgt gttgcctgac 2346481 ctttagttta cctatcataa tgcatgaccg tcaaatcact ttactgtaat ggaagacttt 2346541 attttctcaa atgacttttc acctattcct gaaaccttag tgatatcttc aattgtttgg 2346601 aaacgaccgt tttcctcccg gtatgcaata atagcttcag ctttggatgg ccccacccct 2346661 gagatgcctt gtaactcctc taaggttgct gtattgatat tcaccagcgc tcccttccct 2346721 ccatcgcttt ggacagaccc tccgccacct tgctgcactg ctgtttcctc tccctttttc 2346781 gggatgtaca ccactgtccc gtcctgcaga atctccgcca aatttacttg cgcttcgtct 2346841 gcttgttcac tggtcccgcc cgctttctca attgcctgag atactctgtc ccctgttcgc 2346901 atttcataaa cgccaggatg ctgaacagca cctttgatgt ctatcacaat tgtttcgttt 2346961 gactcgtcgt tgtttgcttc ctgctttacc actgtatttt ctgtctctgt tggtacagct 2347021 tgcttcaccg gctctttatt tttccctgtg gccagaaaga tcataatcgc tgtgaaaaca 2347081 gccgcagaag ccgctaaaat aattgctttc ttatgctgat tcaaccaatt catcgtgcat 2347141 gttccccgct ttcgtcatat tttattttca taacacatat ggtttagagg ataatagctc 2347201 aaaggagggg aaaccattga agataggctt tatcggcaca ggaaatatgg gtacgatcct 2347261 tatcgaatca tttattgaat caaaagcggc cgatccctca aacatgacaa tcacaaaccg 2347321 cacaattgaa aaagcgttgc acataaaaaa ccgctacaac agcataaacg ttaccgaaag 2347381 tctcgaaaag ctcgtttctg aaaacgagat gatttttatt tgtgttaagc cgcttgatat 2347441 atatccttta ctggcaagag cgttacctta tttaagaaaa gatcatattc tcatttcaat 2347501 tacaagcccc gttcaaaccg aacagctcga acaatatgtg ccgtgtcaag tggcgcgagt 2347561 gatcccaagt attacgaaca gagcgctggc aggtgtttct ctcgtcactt tcggcacaag 2347621 ctgcggcgaa tctgcaaaag cgaaaatcaa tgagctgatg cagcatatct ctcatccgct 2347681 gcaaattgaa agtgacatca cgagggttgc atcagacatc gtaagctgcg gccccgcttt 2347741 tatgagctat ctgattcagc ggtttataga tgcagctgtt tcggaaacat cagtgtctaa 2347801 acaggacgcg attttgatgt gtaaggaaat gcttgtcgga atgggaaaac tgttagaaac 2347861 cgaattgtat accctgcctg cattacagga aaaggtttgc gttaaaggcg gtgtaacagg 2347921 agaaggcatt aaagcgctgg aaagcggtgt gcaggatatg tttcaccggg tatttcaaaa 2347981 tactcatatg aagtacgagg aggatatttc cgcagtgaaa aagcagtttc atgtgtagac 2348041 gagtatgtca tacgttcgtc tgtactgcaa aagcataaaa aagcatttta aaaaaccatc 2348101 gttttaggaa acgatggttt ttgatttctg cgccttgaaa aagaggcgtt ctgattgtgc 2348161 tgatggctcg gtatccgtaa aatcagctgt cacgcgatgg agctgaaagc cgcagttctt 2348221 aagcatttct tcgtattctt ccaccgggaa cgttctttgc tcgtgtgtct catcaaaacg 2348281 atcatacgct tctccgttcc acacaaaaaa cgacatatca tgaatgacag aaagctcgtc 2348341 acttccggca aagctctgcc aaatatagct gatatcttcg tcctggtcag caaatgtgct 2348401 atccggaaag acttccgcaa ttttaaaaga tgaatgaaca tcaaacagca ggatgccttc 2348461 aggctttaat acccgaaaaa cacttttaaa ggtttcgatc acatcatttt ttgtttttaa 2348521 ataatttaat gagtcacagc atatcacaac agcgtcaaat tgaccgtcaa agccggtaat 2348581 ctctctcata tcctgctgaa gaaataaaat aggctggcta ctcgatacct tttgctgggc 2348641 gaaagaaagc atctcttcgc tgagatcgat gcctgtaacc tcgaagcctt tttcggcaag 2348701 ccggatggag atttcccccg tgccgcatgc cagatcgaga atacggcctt tttccgggag 2348761 agatgcttca atccattttg tccattgatc gtaaggcgcg tgtgacatta gctcgtcata 2348821 cacgcttgca aagccttgat aaatcattga ttcattccaa agtcaagatc tgcgagcgga 2348881 gcgtctcccc acagcttttc aaggttgtag tagcttcttt catccttgtg gaagacatgg 2348941 acaactacat cgcctagatc aacgagaacc catcttgctt catcaaagcc ttccatcttt 2349001 ttgacttgaa tgccgttttc atcagcttga tccttgattt cacgggcaat cgcctgtacc 2349061 tgtttatctg aatttccgtg gcagatcaga aaataatcag caaccagaga aataccttcc 2349121 atatccagtg ctaaaatatc ctctgcccgt ttatcatcgc aagccgcagc tgcgatcttt 2349181 aaaatggact tttggttcat tcacaaattc ctcctgttca gctgccagac acaagccagt 2349241 tatacgttaa aaatgtgtct ggaaaaaccg gttgattttt tttcataaga aaaaccattg 2349301 tatttttaat ggactgaatc agcgcttgat tcaaatctgt ctcagcaagc ttacgcacct 2349361 catcgacacc gggaaatgcc cggtttggct caatgtaatc ggcaacgtaa atgacttttt 2349421 ctaaaagtgt catgccgggg cggcctgagg tatgatacct aatggcgtca agaatgtctt 2349481 catcttgaac ccctgcctct ctttggacca aataagcgcc gaccggagcg tgccagagct 2349541 ccggattatg atccaataaa tgcgcaggca ttttttcacg cgcaataatt tgtttcattt 2349601 cttctttcgg gcggaatttg gcgtaatcat gaaagattgc cgctatttcc gcttttttag 2349661 aatcggctcc aaaacgctcc gcaagttcga tcgccgtgtt catcacgcca accgtatgga 2349721 tatatcggtg ttcggtcaat tgctgcttca cgcatgcaag tgcctcctca cgattcatat 2349781 aaaccattct cctctacata cttcttcact ttatcaggga ttaagtagtc agtgggcttc 2349841 ttgcttttaa accgttccct tatcatagtt gatgatacct caaattccgg aacgtctgca 2349901 aagagaagcg gataaggggt ttcaacatga aaaccggggc gctttactcc aataaattga 2349961 atgaggttca gcagctcgtc cagcttatac catttcggca aatattcaat catatcagcg 2350021 ccgataataa agaacagctg atcatttgga taacgctgct tcagtaaaga aacggtatca 2350081 aaggtatatg atggcccttc tctttccatt tcaacaagct ccagcttaaa ggacggatta 2350141 gattgaattg caagctttag catttccacg cgatgaaagc tgtcggtata gtcttcgttc 2350201 tgtttatgcg gcggaatttg attaggcata aaccaaattt catcaagccc cgcctggtac 2350261 agcacctcat tcgccattaa gaggtgacca ttatgcggag ggtcaaacgt gcctccgaaa 2350321 attccgattt tcttcatttc aaccaccttt aaggaagctc gatttgttta ttttcctttg 2350381 attccttata taacacaatc gtattgccga ttgtctgcac caattgagag cggcttcctt 2350441 ttacaagagc ttccgctaca tcgtttttat cctcttcgca attctgaagc acgctgactt 2350501 taatcagctc tctcgcttca agcgcctcag caatttgttt aatcatgttg tcgtttactc 2350561 cgcctttacc tacttgaaaa atcggcgtta aatgatgcgc ttttgaacgc aaaaaacgtt 2350621 tttgtttacc tgttaacatt ctgttcctcc taattttcct attacaatag atctcatttt 2350681 ttcaatatta ggctcttgtc cagtccacaa ttggaaagac aatgctgcct gttcaacaaa 2350741 catgcccaca ccatcgagtg ttttcaagcc tttttggctt gcttctttta aaagtgccgt 2350801 ctgtattgga ttatacacga tatcacatac gacggcactg ctcgcggcac gctgtaatga 2350861 aagcggcaca tcgtccacgt tcggatacat gcccacagac gttgtatgga tgataacatc 2350921 atactgctca agacgttctt ctgcttcttt tatgcttaat acttctttat tgtgaaacga 2350981 gggagtagct tctgtaagcc gctttgcttt ttctaacgtc cggttgcaaa tgtcaaattt 2351041 tttcggggta tttcggacaa ttgttgtaaa aatggctctc gccgctccgc cagcgccgat 2351101 cattaagaat gacagttcag agatgggctt gtctaatacc ttcattaatg acttcacgaa 2351161 gccttcccca tcggtattgt atccgacaag cttatctccc tctcttctga ccgtgtttac 2351221 ggcaccgagc acttttgcac tctcatcaat atgatccaaa taatccataa tggaaacctt 2351281 gtgcggaaca gtcacattga ttccttgtac gcctagagct cttattcctt ttaccgcatc 2351341 ctccagatca ttctcttcta ccttgaaggc atgataatgt ccgtcaagcc cgaggtcttt 2351401 caatgatgcg ttatgaatat caggtgacat agaatggcca ataggatttc cgataacccc 2351461 gtacagcttt ttcatacacc tctccccttt tcttaaatta atgaacgccg aacaaataca 2351521 tgaacgcctt ttggcgcgta tgcagttacc tttttatcag cgtcatggac agtaacccag 2351581 cctaacccag agaaaacgat atctgtcttt ttgtctttta tcgtaaacgt atgggcgacc 2351641 aattcaggaa actcatccat ttcatcttta cccggaggtg tgagcaattc ccctgcatgc 2351701 ttttcataaa gcgcgtctgc attttcaagt tttgttctat gaatcatcag ctcattcggc 2351761 atatagcaaa taaaaggaga tctttcccca gacacataat caaaccttgc aagtccgcca 2351821 aaatacagtg tttgctgatc attaagctgg aatgtgcgag gcttcagctc ctttttagga 2351881 gataatattt tcaggtcctt tttattgaca taatgcgcca tttgatggtt gttgataatt 2351941 cccggtgtat cataaagcga tgaaccgtca tccagcggga tttcaatcgc atcaagggtt 2352001 gtgccaggaa attgggatgt tgtaataata tcttcttcac ctgacacttc tttaataatc 2352061 cggttaataa aggttgactt tcctacattt gtacatccga caacatagac gtcttttccg 2352121 ttgcggtaat gctcaatcgc gtcaattact tctctgattc cctggccgcg acccgcactg 2352181 accaaaaata cgtcaaccgg ttttaagcca agctctttcg cttcacgctt catccattgg 2352241 atcagacgct ctcttttcag tgacttaggc aaaatatccg ctttattgcc aactaataag 2352301 atagggtttc cccccaccaa gcgctgcagc ccattaatcc agctgccgtt aaaatcaaaa 2352361 atatcaacaa tttttacgac cagagagtcc gtttctccaa taccgtgaag aatgttcaaa 2352421 aaatcatcat cagttaagga gacatcttgt atttcattat agtttttcag tctgaagcaa 2352481 cgctggcaaa tcacattttc tttcgtaagc gatgcaggcg gcgcgtaccc caaacctgtt 2352541 ttgtcctcgg tttggatcgt aactccgcac ccgatacaaa caaccttttc catttcttac 2352601 tcctcccact gaatgtgccc ttttcgtttg agagcactca gtattctgcg ttcgacctgg 2352661 cggttaaagc gcgtaatgaa tccgtcagag gaagcgactg gcacgaccaa aatcgtatgg 2352721 tagccgtttc ggtttccccc gagtacatcg gtcagcagct ggtctccgat gacaacgcag 2352781 tcctcttttt tcagctccat attgcgcacc gctctattaa aggctttacc catcggtttt 2352841 cttgctttat agatgaatgg gattccaagc ggttctgaga aaagtttcac tcttctttcg 2352901 ttattattag agacaattgt cactttaatg ccgtgttcct tcatttcttc aaaccactcg 2352961 atcaatcgcg gcgtcgcgtt cggcctgtcc cattcaacaa gcgtattatc caggtcagta 2353021 ataattcctt ttacatttcg ttcctttaat ttctcaggtg taatatgaaa aatatttttt 2353081 acaaactcgt caggtaaaaa aaactttttt aacaaaaccc gcacccttcc ctttttcttt 2353141 ctttcaaaat gattgtcgaa aaaaatcgaa cttgcgccta aagaaaaact gagcaaaaaa 2353201 atttcgacaa aaattgggtt tcttcaccag gtgtggataa atttacacac actatccact 2353261 cttattacat cactctttag acaaattata aacacgatac tcacaagtta tccacttttt 2353321 ggtgtggata acagaacgat tgttcttata tgcatttcat ggtagattaa agataacttc 2353381 aacctcagat gaatgcaact tatcattgta tgcgttaaaa tcatgaatga ttccaacttt 2353441 taaggaggtg cctctcccat taattgggtt cctagcatga gaaaactgtc tgatgaatta 2353501 ctaatagaat cttatttcaa agccaccgaa atgaatttaa accgtgactt tattgagtta 2353561 attgaaaacg aaataaaaag aagatcgctc ggacatatta tttccgtatc ttcttaatag 2353621 gaatttgtct attttttccg ggcgtatttc ctttttttac tcagatgact gatattatat 2353681 cactttggct gcgcgcttta ctactatttt cagcaaaaaa cacccctaaa aagaggtgtt 2353741 ttaaagggcc ggttattatg ctaaccagta tatgccgccc acaacaagga gaacaacaac 2353801 taaaacaaca ataaaagcgt atccatatgc tctgcctgcg ccatacatgt gaagcgcctc 2353861 cttaataagg ttttataaca gcctatgtag gagaaataaa tcggactagg cggttgtccg 2353921 gctcaacgct gcaggatctg cccatcttgt attccttcat atacgatcct tgccccttta 2353981 ggtgtcatat gatttccaga aggatctata agaccagatt ggataagcgc ttcatcagtt 2354041 gcttttccgc cgtctgcttc tataaaatgc ttccagttat ctacaagagg gacatccagg 2354101 cgcttcgaca catctcttgt aatatcgtta tatgagttgt gccatttcct tgctccgcct 2354161 tttggttcaa aagcagctgc ttgatatctg gaatagtaaa acaaatgatg cttcccatta 2354221 ccttctataa ttgggataca cgtcattaag attggcttga tcccgtgttt tctgctttct 2354281 tcaataaaat aaaccagatt ttctctaaaa cgctgcttcg acactctcgg tttcccctca 2354341 gtcagtatgg cagcgtcatt ggttccgaac ataataaaca aatacttcgg tttttgatcc 2354401 agcacatctg tctgaaatcg gagacgggca tcctctgtcg tctgtccgcc gattcccgca 2354461 ttgagtatat caaggttacc gcgctcagct gtttttaata tattgaccca ctgctgtgct 2354521 tttggataat cgcgataatc ccaattagag ccacgcgtat tactgtcacc aaatgctaca 2354581 acgtcttcgt atccccttcc ctcgcatcct gctgtaacga acagcagaag gaaaaggatg 2354641 ataaaatgtt tcatctttac acccccaaaa gcctcacttt aatgttatac ctctgtttct 2354701 cttcgttcaa tgaagagttt ttcgctatca ctgttttttc ctatagttaa cgtgtccccc 2354761 tcagtgaata tcattctgct ttcattgcgg cgcagctgat gattttttaa aattcccttc 2354821 tttccaatct gaaaaacaca caaaccaaag aaaagaaaat aacctgaatc cgcactggaa 2354881 acaggttatc cgttaaatcc tgcatttact ttaacttcga tttaagcttg gcctttgttt 2354941 ttggcccata aatcccgtct gcagttaatc cgttcatgag ttgaaaacgc ttgacggcat 2355001 tcgctgtttt cggtccgtaa actccatcta tgccattgtt tttggctccc ttatcagggt 2355061 aaaagtgaag tacagctaaa gccttttgca gctggagaat gtttgtgccc tttcgataag 2355121 gcgaagtgag ctttataacc ccagacggca gaggatatga tggtgaagtt tcttttggag 2355181 gtgtatccga ggaagaaatt ccgtttagaa aagagttcca gtggtccaag agtttccgcg 2355241 gacattcttt cccggaccac tttttgtggg gaacaacacg atttaacgga atattgtttt 2355301 ccttcatcag ctttctgatc agccactggg catttgatgt tgctttttca aaatcgccgt 2355361 cagcattttc acagatttca atcccgatcg atttgcggtt tcctgtcccg tttgtaccgt 2355421 ctcccgcatg ccagccgttt tcatctatcg ggagatgctg ataaatgact gaatcgtcaa 2355481 ctgtaaaatg ccagctttcg gatgtgttcg ggtttttcac aaacttggcg tgcattttcg 2355541 catcagcgcc tttggctgta ttcgctgtat tatgcaccgt aatataagca ggcgccatcg 2355601 catagccagg acgattatca tttgataccg gtataaaatc cttttttatg gttaccattt 2355661 ctatccctcc ctattaataa gaatgcagaa aacagagaga tggacagcct tttttatgag 2355721 gtaaaaaaga attgtgttct taacctggtt ttcagttgaa cagctgaaat ggcaccagtt 2355781 atactaattt agatgacgga ggttttgact cctgacatca cctaagttgg gagtgaccat 2355841 agacatgtta aaaaaagtaa taggtatact tgtgattatc gctatcattt cagttggttt 2355901 ttttcagaaa gaagcttggc ttgatgcaat caaagcagga gggatgtttt ccgttttatt 2355961 tagtatgctg ctgattgctg ccgatgtttt tttcccaata gtgccgtttg ctttgattgc 2356021 tgctttaaat ggcgcagtgt tcgggactgc aaatggaatt tggattacac tgaccggctc 2356081 aatgcttggt acaatattgc tgttttttct cgccaggtac agttttagag attgggccag 2356141 aaaaaaagtt caggcctatc ctgccataca aagctacgag gcttccttca acaaaaacgc 2356201 ttttaccgct gttttattag gaaggctgat acctgtcata ccttcacttg taatgaacgt 2356261 gatctgcggg ctgagccagg ttcgctggca tgtttttttc tttgcgtctt taatagggaa 2356321 aatccccaat attgttgttg tcactattgc aggtgccaat ttcaccagca ataaattatt 2356381 gtctatcagc atttacggta catatattct gatcatcatg ctggtcattt ataaaaagtt 2356441 ccctcatctt ctgaaggtgc caaaaaaata aggaggcttg ttggccccct tacttttttt 2356501 ctgtcgcatg gcctccaaat tcatttcgaa gcgcagcaac cacctttcct gtaaacgtat 2356561 cgtctgttaa agaacggtat ctcatcatta gtgacatggc gatgaccggc gttgccgtct 2356621 gcagatcaag cgcggtttcc accgtccatt ttccttcacc tgaggaatgc ataatgccct 2356681 tgatctgatc cagtttcgca tccttagcga aagctcgctc agtcagtccc ataagccaag 2356741 aacgaatgac agaaccatga ttccacactc tggcaacctt ctcgtagtca aaatcaaatt 2356801 ggctgttttc aagcacttcg aatccttcac caatcgcggc catcattcca tactcaattc 2356861 cattatggat catttttaaa aaatgtccgc ttcccgcttc accagcgtat agataaccat 2356921 tttcgacggc agtatcacga aaaagcggtt ccacaatctc ccatgcttca tgatcgcccc 2356981 ccaccataaa acaggctcca tgccgtgcgc cttccattcc gcccgacgtt ccggcatcga 2357041 gataatggat acccgcttct ttcatttgat tgtagcggcg aattgattct ttataatgag 2357101 agtttccagc ttcgataatc atatcgcctt tacttaataa aggtgataca tcacgcaaaa 2357161 cagcatcgac aatgccatgc ggtaccataa cccataggat gcgcggcggg tgtaataaag 2357221 aaatgaactc tttaagattt gttgtcccct cagccccgta tgctttcagt tcatcaacag 2357281 ccgcttgatt tacatcatat ccaaccactt gatgattgcg gtcaatgaat tgctttccta 2357341 tgtttatgcc cattttccct aagccgatta atccgatttt catatctgtt cctcctgatt 2357401 gtctaaaaag cctttactct ttatgttccc tatggattgt attgtgatac gcagaaaaca 2357461 aatggggctt acatcgtctg cgcatgtaaa ttttattttt catgaccgac ggcgcctgcc 2357521 agttctatta ctgaatctct ttatatccat aattatcgct ttatccttga tttaccatca 2357581 gtttaagtta aaatatggga aggaattcga ttttttcagt aaaaagaagg tgacatgttg 2357641 cagaatcaat ctcatactct tattggagtt acgaaaaccg ctgtattctt tttatacgct 2357701 gcacttgcaa tcatcggttt tgcaatcggg tattttattc cgcagattgc gaaatgggca 2357761 ttatccctcc cctggatccc tcttgaagga ccacttcggc tcattacctc ttttcaggga 2357821 tctacagctt catttatcac tgctcttctc ggtatgtgtg cggggatttg gttcgctcat 2357881 tctgttattg caatgctgct gtctgtcaaa attacagatc acacagtgga attcatcaaa 2357941 ggaaaaaaag tgcaaacaat tcattccgat gacatcgctc ttgtatttat ggatcacaaa 2358001 cggcttgtcc tcctgggaac agccggatat gaattggtac gggaagaaat tgatgaaaaa 2358061 ccagtaaacg ttgagaaggc ctttagacag catcattacg aatgggcaac agatggtgat 2358121 ccgtttaaag atcaatttcg ccgatggatt cctgatgcac cagacctatc gcaaggcgcc 2358181 catgccttat taaaagctcg tcacaaagca ctgcaggacg aagaaaaaga cgatattgaa 2358241 gaattccgtc tcgaactggc acagctgggc atcgttgtac gggacgaagg cacacgccaa 2358301 tattggcgaa aagcagaaac ctatcccccg aaaattcagc tcggcgaagg attgtaacaa 2358361 cagaggctca agaaagagcc tcttctttac tactgcacaa taaacagcac tctggtaccg 2358421 tcaggatagc tgctcatttg attccctacc cacgagccgg cgccgcgatt atcagaaggc 2358481 gtcacatatc ggacatcagc ccctgcaccg ccttcctcgc agaccgccat cggccactca 2358541 tcccggtcat agcccggctt ggtcgggatt ccctttaaag attcctcccg ccttttgtct 2358601 gctccatctc tgtcaatggt acaaatatct ggatgtccct ctgcaatcgc atccctaata 2358661 tgactgccgg tttccggata acgagacagc ggaaaatata acactttgtc atacgaagat 2358721 gcgccttgga tctgttgcgg aaccattaaa caaagaagaa ctgctgcagc aagaaacagg 2358781 cctgccatcc attttttcat ccccatcccc ccataccttt gttcatttca atgtatgggc 2358841 gcttgatgaa gaatattttt aacatttgaa gttagtatgc tgcttaccaa agccggactc 2358901 ccccgcgaga aatttcccgg tacagacaca gacagcctcc cggtcacata catttacata 2358961 taggcttttg cctacatact tttgtggagg tgacgatggt gacaggtgtt ttcgcagcgc 2359021 tcggctttgt tgttaaagag cttgtctttt tagtatctta cgtgaaaaac aatgcctttc 2359081 cacaaccgct ctcaagcagc gaagaaaaaa aatacttaga gctcatggct aaaggggatg 2359141 aacatgccag aaacatgctg attgagcata atcttcgctt ggtcgcccat attgtgaaaa 2359201 agttcgaaaa tacaggtgag gatgcagagg acttaatctc catcggaacg atcgggctta 2359261 ttaaaggaat tgaaagctat tccgctggaa aagggacaaa gctggcgacg tatgcagcga 2359321 ggtgtattga aaatgagatt gtaattacaa aaggggggtg catacacccc tctttaatac 2359381 gtttcaatat atatggtgtc agaatccaca atggtaactt ctttcacgat aaagttaaca 2359441 attgtttttt tatcttcaag agttaagtta tctgcaccga ttgattgaaa atagtcgatg 2359501 gctcttttta gagcattttc acttgagctc gtatcatcta ggactttcat ttttgactgg 2359561 atttcgttac acttttcagt aagctgattt tgcttttttt gcagttcaat aatttgtgct 2359621 ttgatttcat ctatgtctaa atcatcgtca tcgcttaggc tgattagcgt taaaagacgc 2359681 ttgcggcctt tttttgtttt ctctatctct ttttcaataa gttctaattc atcagacagg 2359741 tgatttgatt gttcagcctc tttaaaagaa acatactttt gaggatttgt gatgaattta 2359801 aaaatttcac cccatacatg ccggttcaat ttattctcag acatttcttt tccgcagccg 2359861 cggtcctttg cgccagaata atttttccgg caagtatata catagtagtc tttaccatgt 2359921 gattttcttt tcttccctgt catggtattt ccgcattttc cgcatctaac caaacccgat 2359981 aacaagtaat tgtgagggct gatactcaag tgttttcttt tactttgacc taagagttct 2360041 tgagcataat cccattgttc agctggaaca attgctggaa ttgtcacagt gatttgttct 2360101 tcttcaggcc ttattttaat tatagatttg ttccctgcct gctttgaaac ataggaaccc 2360161 tctgtatcat atttatactg tctatgttca cccttatagg aagagttcat taatatttgc 2360221 cgaacaacct gcctgtgcca tactttggcg cctttttttg ttttaacccc catctgagtt 2360281 aaatgtagag caataccatt tactctgccg aaaaaagggc ttttatgatc ggtgaaatag 2360341 ttaaaaatca tccgaatgat ttttgcttcc tcttctaata tctcaagagt tcttttctct 2360401 ttaacaaatt tatagccata tagtttagaa tctttaatga tcatgccttt tttcattttt 2360461 tgaagtcggc cgcttgatgt ccgttctttg attttggctt tttcaaattc tgagattgcc 2360521 ccgcgcattg cgaaaaacaa ttgaccttct ggagaattgg cgtattcacc atttacaaaa 2360581 atcaaaggta tgtttcgctt tcgcaattcg tcatcaatga ttagctgatt cattaatttc 2360641 cgagaaagac ggtcaggatc gtaacaaatg acttgactta taagtccctt gcttgcatcc 2360701 tccctcaagc gattcaaagc cggacgttct aaaagctctc ctgaaaatcc ttcatctgca 2360761 tacttcagca catctttagt ccctgctttc tttatacagg cctcgatttg gctgtcgatg 2360821 ctcgatccct tgatcgcttg ttcctcggtc gataccctta catatattgc tatcaccctg 2360881 aatctccttc ctataaagtt ttattaaata atgatagcaa tcgttaatgc atttgtcagc 2360941 ttgcggtccc tcgatgatta tcactttcat aaaatgcatc accccttggg taatgctatg 2361001 taacagctgt ttgtccaaat gaggagattt taaattaaac tatagtgtta ttaaacgttt 2361061 caatgaatat gcaaaaaatt taaaaaaagt tgttgtgact tttctacact cctttaggtc 2361121 ctcaatagaa aagattttat tttctatgcc tcaacattcg cttattatag ttttcaatga 2361181 tttattatta tttgagagta caatggagta gtgtttttca ttgttagata gttaatgaca 2361241 tttcactggt gtcaagttcg tatagctaga cattaataaa aaaaggacac atataaatat 2361301 gcatccttta acaaaagagt ttatttattt ccctgtttca gcaaattcct tcaacctatt 2361361 ccctatttca tcacgaactc tttggaaaaa cgcccatttt tcttcttctg tcccttgtgc 2361421 tcttgccgga tcatcaaaac cccaatgctc acgttttaca tgtggaggcg tcatcgggca 2361481 tttatcagca gcatctccac aaagcgtaac aactaaatca gcattgttca gaatatcaga 2361541 atcgattata tctgacgttt gattagagat atctatacca acttccttca tcgctttaac 2361601 agcattcgga tttaatccat gtgcttctat ccccgcgcta tacactttcc actcatcacc 2361661 taaatattgt ttagcccatc cttcagccat ttggctccgg caagagttcc ctgtacataa 2361721 aaagtaaatg attttattct ccatatattc cacctctaca tcgagtgact tccaaagtat 2361781 tttcgttgaa accataaagc aaccttaaca agtgctatca tgactggcac ttctacaagc 2361841 ggaccaatta cggcggcaaa tgctgcaccc gaatgaattc gatatcaagc ttcgcactta 2361901 aacacagcgg aatttataat atatgcttgg acagccgtaa aagccgaact gaacaatggt 2361961 atgattttgc tcatgaattt tgccatatat atagacatga aggcgataaa aaaacaatgc 2362021 ctgcaacttg gactgattat ttggattggc agtccaatta ttttacatat cacttttgca 2362081 ttccaacttg catgttgcgt aatatcaacc ttccgtacat acaatcacat gcaattgaaa 2362141 atgtagcttg gttatttaag gtatcccctt cattcgctaa gaaacgttta agcatttatt 2362201 acaggaaact gactcaacat ttatttagtc aaactgttac gggaaattta tgccccccct 2362261 ttttgtaatg aataatgaaa tcctcatgca tttgcgcgca ttgaaaaaaa caaaaaaaga 2362321 cgtctccctt cacgatccga tcgggcagga taaggaaggg aatgaaataa gcctgattga 2362381 cgttttgaaa tcagaaaacg aagacgtgat agatacgatc cagctcaata tggagcttga 2362441 aaaagtgaaa caatacattg acattttaga tgaccgtgag aaggaagtga ttgtcgggcg 2362501 gtttggactt gatttgaaga aggaaaaaac gcagcgagag attgccaaag aactcggtat 2362561 ctcacgcagc tatgtatcgc ggattgaaaa gcgggcgctg atgaagatgt ttcatgagtt 2362621 ttatcgggca gagaaggaaa agcggaagaa ggcgaagggg aaataatgca gaagaagccg 2362681 gatctcatac tccggctttc tctatttgaa agagttatga aaatcatttt tttcatcgct 2362741 gataagctct ccgagaaaga caggcaggat cgtaacaaat aacttgactt ataatcctcc 2362801 cgcaggcatt caaagccgga cgttctaaaa gctctcctga gaaaatcctt agatcggtat 2362861 acttcagtac atctttagtc cctgctttct ttatacaggc ctcgatctgg ctgtcgatgc 2362921 tcgatccctt gatcgcttgt tccacgatat attgctatca ccctggatct cctgcctata 2362981 aagttttatt aaataatgat agcaatcgtt catgcatttg tcagtttgca gtccctcgat 2363041 gattattacc ttcataaaat acatcacccc ttgggtaatg ctgcgtaata cctgtttgtc 2363101 ctaatgaggt gattttcaat gagtatgaaa acaaataaaa aaaccgatgg tttgtaccat 2363161 cgatctgttt tctatatcac taggccctca atatagtaaa tctagctcat tggttatgaa 2363221 agcttatttt cattacacac tatatattca tttgttatca tttctatacg tttatatcaa 2363281 ttatggtaaa aaatggttac aaaaacccaa taaacgtcca acctaacttt ttcatcttat 2363341 ttattaagaa ttttaacctc ttccttgtga aataaagaag cgattttcat ctccaaacag 2363401 ttaatgctat ttcatcggga catgtctgtt aaagtagcca ataaatacat tcggatatcc 2363461 acttacaacc acgattcaat ttgatccact acagatttct gagctgacat taaacagata 2363521 gagttataaa aatctgtacc agttcccttt cacaattagg acatttcggc ggcgtttcgg 2363581 cataatgcga actaatttat taatgttcaa caacagaatt tcgtctattg gcaataaaga 2363641 atccacaaat cattgcaaga atggccatcg cccaccagaa cgttgagatc gcctgatcat 2363701 gatcgatgat aatcaaacga atgacagctg tgatgccaat ataaatgaag tagcgaagcg 2363761 gaaaatgaaa gtctgatttg aagtatttga taatcaaagc aatgaactca aagtacatga 2363821 agaatataag cagttctcca agcatctcat aatagctgtc cactttgttg aacagtgact 2363881 tgtatacgaa tagcacaatg taccaagtct cgctgatcag aagtgcgctt aaggctaacg 2363941 ccagaaagaa cagacagacg ttgagaagcg cttgtaacag gtaaggcacc tttttgaatt 2364001 tgttagaaaa tctcatcatg ttgtctccta tttcaatata ttcgtggttt ttattctcag 2364061 cctacatctt ggtgttccaa aatcgtagca caatgtagta cttagaattc ttttgtatac 2364121 tgtgaaactg tccctgcatg cgggacatca ttcgcgcaat gcttctttca ccgagtccgt 2364181 tgctttccgg tgttatatct gcaagtttaa tcgtattgct aacatggatc tcaaatatct 2364241 cttgatccga tacaaacgtg atactgattt tttcttccgg atctgcgtat ttcaataagt 2364301 ttgacatcac attatcaaat acacgaccaa gctcctccaa attcacgtta atataggttt 2364361 ccggcagctc gcctgaaata tggacccgaa aatgctcctg atgaaggata gcaatctgat 2364421 ctgatattag atcgtagatc acttctttca ctgcaacggt ctccagatcg gcctcatatt 2364481 ccttgttcag caggaaatac gcaaacagat tgtcagacaa gctttttaat tgcagtgctt 2364541 taccataagc attggctaca taccgatctt tgctggcacc cgcttcgcct ccctcttttt 2364601 tggcaaactc cagattcatg atcagcgacg tcagcggtgt gcgcatatcg tgcgacattt 2364661 cggtaaccag gctgcggctc tcagcttgca attcctcgat agctttaagt ttatccagga 2364721 aagctttccg cagatcctca atgctctttg caatcatcgc taattcatca tgccctttta 2364781 tcgtcatctc gtagtccagt tcgccccctt caagaatatg aatctcttga tgaatcgttt 2364841 taaggtagcg aagactttgg cgaattccga agagaacaat gattaaaaag atgagggttg 2364901 ccccgagcaa atccaatgca aaggccagat cataatatcg ggaagagtag aaaccgtcga 2364961 taatgactcg tccttcacca tcgctaaact tgacaggatg tgaatgattt tgagcgtact 2365021 gagtcagctt ttcctttcca taatccgatt cggaataaat agaatcatat tgcagctcct 2365081 gatccttgaa tatggtgagg ttaatgtaat tttctttttt gacccactcg ccaaacgctt 2365141 ttctatctga tgtagacaac tcattttctg aaacgtactt gctgaatttt tgaatgtatc 2365201 ttgctgactc ctcgtgataa tactcttccg aactcagata tccctcgatc agatcatctg 2365261 tgatcttttg caacgtcaga aagatcacac cactcacaat cgcagcaacc attatcagca 2365321 aagccagttt tttggttagc gtaaatttaa gatgcgccaa atcgatatcc tcttccccat 2365381 tcagttttta tataaaccgg acgtgccgga tcatcctcaa ttttggagcg cagcttccgt 2365441 atatgcacca tcaccgtatt gttggaacag taaaagtaag gctgtcccca cacactctca 2365501 tatatatttt gggcagaaaa tattttgttg cgtttgttca tcagaagttt caggatacga 2365561 tactccagat ctgacaactt gatttgcttc tcctctttcc acacctcatt aaattcttcg 2365621 ctcactctta gtttgccccc gataagaaat gtttcttcct gttccttctt ttcctgatag 2365681 atagtatatc tgcgtaattg agcaatcact ctagcgtgaa gttcctcttc cgagaatggt 2365741 ttagtcatat aatcatcgcc gccggcgagt aatccctcag ttttatcgag tgtactcgat 2365801 ctggccgtca gaaacagaat cgggacgtta gaggatttcc tgatgtgctg acatgtttca 2365861 attcccgaaa tgcctggcat cataatatcc aaaataacca aatcaagcga gtcattcaca 2365921 agttgcaatg ctcgctttcc atccttggct cttagcacct cgtaacctgc acgtgtaagg 2365981 gattcctcca aaagatcacc aatatcctca tcatcctcta cgactaatat tcgataggcc 2366041 atgtctctct cacctcatga ttcttgttgt tatttctcgt gtgtccttac tatatatcgt 2366101 tcatagtaat aagtacgtta taagatacta cgtaaatctt aacaatttat gaaagctgat 2366161 gctcgccaca aatttgtcac attttctaaa aaaaatgatg actcttcata aattgttaag 2366221 attcggtctt tatatttatc cattgtaagg ctcaagtttt tcagatccgc actacacatt 2366281 gccgtgataa atgggaaagg agtattgata tgattgtaca aaaagaagga cgcgggcaac 2366341 cggtgagtct gcgggaacgg gttcattttc tggacatcgt acgaggattt gccttgcttg 2366401 gcattattat tgtcaattat tttctgatcg tagattcagt aaagggattc gaaatggcct 2366461 ccgatgacgt actgcataag ctggtttcct ggtttgccga agggaaattc gttacgttat 2366521 tctccttcct gttcggagtc gggtttatga tctttatgga tcgagccgcg cagaaggtag 2366581 agagtcccaa caagctgttt gcccgcaggt tatctatcct gttgggattt ggcattttgc 2366641 acatcacatt tgtttgggtc ggtgacatat tggcctttta cgccgtaagt ggcttcctgt 2366701 tactcgcctt ctataaacgc acggccaaaa cggtgcttag atggattatc gcacttatcg 2366761 tgtttcaatt cctgactcct gttttcacaa tgttgtacaa tgtcatcaat actgcagggt 2366821 caaaaaaccc gaatttttca gagtttactt tgtttagcca cagcagcctt acctacatgg 2366881 aatccatcag cactcggtgg acagatatgg tcacgatggc tgccggctct ttctctatga 2366941 tctattccat gtttctcatg tttctgctgg gcgtgtactt tgttaagatg gaatttttca 2367001 aagacatgga agcgaaaaag cctatatgga agcgtatctg gatcattagc acaatcgctt 2367061 ttctaataac acaaagcagt atattactag acatgtttaa tctttctgag aatatgctgt 2367121 ggaaggacat ttcctctgtc ttgggtcaaa atggcggctt aaccggaagt atgttttata 2367181 tgagcacttt tgcaatgctg tttctatacc ttcctcagct gcgaggccct atgatgatat 2367241 tcaccaaagt cggacggatg tcattgacct gttatctgct tcactctatc attggaacag 2367301 ttctgttcct caggtacgga ttcgggcttg cggatcatat tcaatccgcc ggcacgttca 2367361 tgttcagtct ggccgtgtac ttcgttctta tgagctttag tacattgtgg ttgaaacggt 2367421 ttaggtacgg tccgatggaa ttagtatggc gcaagctgac gtacggcaaa gtaaacggga 2367481 gtcccaaagc aactccgctg cattcggaaa aatctattca gaaataaccc ccttgcacag 2367541 attgcatgac ttcaaattag tgttgttgaa tgaagcgggc attaaacgga cagatttgat 2367601 atatggacta gttattttta tatcatttag gcttctttgg gctaataaat ccaccagagt 2367661 ttactcaatg tgcattgctc atgatcgaat ctaaattgaa tcttttacgc atgttcatag 2367721 tcaaaggcgc ctcattcgac tatttttgta acttttcgca ggaaaaattc gagaatgatg 2367781 acaaatcccg catacgacac ttaatacggt agtgaacaat agtaaattag ggttacatgc 2367841 agcttgtttt ccaatgaaac aaagaaaaag aatcatacaa aaagacagga gaaagctttt 2367901 gaagtatttt aacgccaaat ttaccgcgga agaaagagcg atggaatcac ttttttgtga 2367961 aaaggcctcg cagagcagct cgaatgtttt actgaacgac tgaactctat attttagcaa 2368021 ctgagggagt gaacaatcat gaaaactaaa aatgaaccaa aagttattct ggaactagca 2368081 aaggaatctg atctgccaga attccaaaaa aaattacaag aagcctttgc gatcgccgtg 2368141 attgaaacgt tcggtgattg cgaagatggg ccgattccat cggacaatga tgttcaggag 2368201 tctttcaatg ctcccggagc agtggtatat catattcttc aggatggtaa gaatgtcggt 2368261 ggtgcagtag tacgtatcaa cagccaaaca aatcataatt cgctagattt attctatgta 2368321 tctccagaat atcacagcca agggattggt ctttctgctt ggaaagccat tgaagcacag 2368381 tatccggata ctgtgctttg ggaaaccgtg acaccttatt tcgaaaagcg aaatatcaac 2368441 ttctatgtga ataagtgtgg atttcatatc gtagagttct acaatgaaca tcactctaat 2368501 ccgcatatgc atcgcaatgg acgtgaagat gacaagcccc tactgaatga tgatgacttt 2368561 ttcagatttg taaagattat gaaaaaaaag gactaaacaa ttgaacacgg cgagatgccg 2368621 cagagagttg ctggtaactt ttttatattt cattatcaga ggaaggtaat aatgatgttt 2368681 aaaaggtgtt ttgatccctg tctcataaac aggggtcaaa acacctttga atcatcggtt 2368741 tcttttctga catataccac gcccactagt ccctcaacat agtaaaaaca tatcatgagt 2368801 tacaaaagct tttattcaaa gcatatgttt attttattta tacttatttt catcattttt 2368861 cagaattctg gacacaaatc gggtacctat tagaggccaa ggaactctac atttcattaa 2368921 gaaatacgta ctcattgccc tgctttaatt aattttaagc cctcgcacta tgcccccccc 2368981 tgaattaagt atttgatgta actttgaaat taagtttatg aaaatctgtc acaaaccctt 2369041 atttcataac acatcatttg tttcagcttc cctcgcgaat accggattaa tgctcggctt 2369101 taagatagtc aaccaatctc tccgcactgt tcttaacatc ttcttttgaa agatgaagtg 2369161 tcccatattg tgtaaacgca ggaagaaaac gcattcctat atagttagca gtgacttgaa 2369221 acggtctgat aagctcgctg atcgtgatat tatattctcc gcctgcttga taatcagatt 2369281 cctgtgcgcc taaggagata gctaagagta gttcttttcc atgcaattta gttcctccag 2369341 ttccataagc ccagccatgt gttaacacat catcttccca ttgtttgagt aacgcgggac 2369401 tgctgtacca atacattggg aactgaaaaa cgatacgctc atgatctaac aggagctgct 2369461 gctctttttc tacatcaatg ataaaattag ggtattcacc gtacaggtca tgaaccgtaa 2369521 tgtctttctc ttgctttaaa cgattcatcc aggttttgtt gacaacagac gtttccaaat 2369581 taggatgtat aacgataact aatgttttca ttagactgat tatcctttct ttgccaatta 2369641 gttattattt tttacgataa tgaattgatt ctaattttaa aatagcaact ttatttacac 2369701 ctattttatc ctttttcatg aattcagggc aactaattgg gcaccaaaat caatgatgac 2369761 ttaagacatt gttttgtaga aatccgatat acagaataat ccattattta gaaaatttct 2369821 accttttccc tcaatcctta ccaatttaaa ctcattaagg agatacttta tcaccaactt 2369881 taaataataa tggaataagt gctaataaaa taattcctac aaccaacgta gatattatta 2369941 actccttcca tacaatcaaa ttctttaaaa acatttgata aataactaat gagtttactg 2370001 gaatgttaag caataagccc gtaagaagtc caggtgcata ctttttcatt acaacagttg 2370061 cgataagatg tggaaaaata gcgttgataa ccatagaacc tagaaagcca atgaaaatcc 2370121 attttgcaat atctgattct ggcatatata aaaaaccaaa tgcagataaa taagccaaca 2370181 tagttataac aatgacagca aaatgaaatt catttgaagt tactggcttt tgaaactttg 2370241 aagattgttg tgaccactca ggtaaccaaa tagcttcctc aatattatga agtgtaatag 2370301 caaaacaaaa aaatgctacg aaataaacca cctatcattt cctcctcggt gccacaacca 2370361 atatggtttg gcaacattat attacatttg aggctgattg gatatggtgt taaaagagag 2370421 aagaatctgc cttagtagtt gcttcttaat tatatgtgca ataacgtgtt gttacgtggc 2370481 atgtcatatt caaatataat aactctaaag caaacaaaga tacctatata gtttggcatc 2370541 ctctttttta gttcgagtcc ctctatttat tttgggcaca aaatagacat aatttatatt 2370601 gactcattat acccatcaca taccataccc cttaaaccaa tcaggattaa aatgttttaa 2370661 aaaaggtgat caaagattaa gttatggtct cttttatttt atgtatgctg tcttaatgca 2370721 aaacaacact ggacaccact aagtcaaatg catttcatgg tactatagtc aagacttgtc 2370781 caagtcacca ttatcaaaat gaatttcatc aaacacttga aacatttatt gaacgcggcc 2370841 aagtgtcata acattaataa gaaaccaacg agtgatgaat cttttaatct ttcattttac 2370901 ccgctggctc atatcaaagg agctctaacc aaattttaat agctgtcgca cctattaatt 2370961 gcgctaaaac ccattgcagg aattttgtat ttactttttg cccaactgat gcgccaatag 2371021 gagaagctat taaactagta atcataagaa ccagagctgg tacaaaaaga acctggcccg 2371081 tgattacttt tccaactgtt gcgccaatgg atgaaagaaa tgtaatcgca agagatgaag 2371141 cgactgtgac tctaacagga atatttaaaa tcgataacat aatggggact aggataaagg 2371201 cgccgccagc tcctaaaata cctgatacgc caccaatgat aaacgctaag gaagaagcca 2371261 accatttatt aaatatcact tccttatctt cgctatgttc ttgtcctttc tgtccttttt 2371321 taggtataaa cattaaaata actgctataa tagccagaat tccgtatata aagttaattc 2371381 ctttttcaga tatataatga gaaaagtaac tccccaatac actccctaaa aggatgctgc 2371441 ttcccatgta aataattaat gttttattta taagaccact cttacgataa gcccaaacac 2371501 cgccgagtgt cgcaaaaaaa acttgaatag cccctatccc tgaaacttca tgggcagtta 2371561 atgacatcac tcccactaaa gaaggaatgt acaatagcat tggataatta ataactgctc 2371621 cgccaatacc aatcattccg gaaataaagg caccaataaa ccctataatg aaaagagttg 2371681 tgataaaggc aatatccatt ttatttgcct cctttcatag gaaaagggta tctttctatt 2371741 cgataccctt tcacattcat tagccttttt gaatccaaaa tttcaatata tcgccctcgt 2371801 ccgtttgctc taaaaggtca tgtccgcctg atttagacca ggctgtaaga tcatttttgg 2371861 ctcccttatc tgttgcatgc acttctaata tttgacctga ttccagttca ttcatcgctt 2371921 tttttgttct gacaattggc attgggcatg ccaagccttt tgcgtctaat actttatctg 2371981 atttcatgtt cttctctcct ctttttagca gaaacttgtg ttaccgtatt gcacagcggt 2372041 ttgggccaat ctccatttca cgctgttttt cttcatctgg gctgattttc cccatgtttg 2372101 tttctcgaat ctcttggtat gcatttggtt gcggaggcaa atgatctgtt actaggtgtc 2372161 taaattctgt ttcatccgca atgttcaaac catggttctc gctaaataat gtacttagtt 2372221 gtttaccaac acttccattc tcatttagct cgtcaatgat cataaagtgt gccggtaata 2372281 caattaaatc ctttgataac gctttgtaac ggctataaag cgtttttctt aaatctccta 2372341 cccaatcttc tgccataccg gctaagtctg gtctgccgat tgaatcaata aacaagatat 2372401 cacctgaaag aagatactgg tcatcgacaa tgaaagaagt ggagccaatc gtgtgccccg 2372461 gagaataaat cggttgaatt ttaatcgttg tatttccaat aataatgtca tttccttctt 2372521 ccaacggctg ataatcgaat tccacttctt cagcatcttt aggcggtaac cagtaggttg 2372581 cttttgtttt ttcagcaatg actctgccgc ctgaaatatg gtccgcgtga agatgtgtat 2372641 caaatacgtg agtaatcgtt gcacccttcc ccttcgcaaa atctataaag aaattcacca 2372701 tacgtgtcgc atcaataatt gctgcttcac cattggaaat gaccatgtat gacaagcagc 2372761 ctttaccgat tcgaacaaac tgatacatct caccgccatc ttttaaatcc ccgactttta 2372821 ccggctctaa atgttcgctc catgctttca ttccaccctt aaggtaggat acagaatgac 2372881 ctgcttcaga aagcatttcg gataccatga cggatgaacc ttcttttgcg caaacgacca 2372941 gcacttcttt atcagaagga attttctcca agatatcttc tacgccatct aaaagatcaa 2373001 aataaggaac attcaaatgg tcaaagtcat gcccttctat cttccaatca ctaaaatcat 2373061 tttcattacg cacatccaaa ataaataaag gttctttgtt aaagattttt ttgtcacttc 2373121 ttttggggtc attgccttta cggtcatgtt tcaatacctc ctatatcaaa tcttttagcg 2373181 ggactaaaac gttaaggata catcagcatc tttcgtaaaa ccaaaaaagg taacagcccc 2373241 gcctacttcg attccttcca taaaatcatc ttttgttaaa cccataacgt ccatcgttat 2373301 ttgacaacca aatcatgcaa ctcccatttc aatcagttaa gaatagaagg cacatttgcg 2373361 ttcctacaac cttctgcgac atgctctttt ccttgtcgca atattacaga ctttataagc 2373421 atcaaacaga ccgctatttg ccgcaataat cgctactctt gtactcatct gttcatcatg 2373481 ctttttattt attcggtttt acctgtccaa tcccgcatac ccgggacaac attaataacc 2373541 tttttaaaac cttgtttttt catggtgcgg gccgccattt cactccttct tcccgaatgg 2373601 cagataatat aaatttcatc attttcgttt aattcgttag cgcgcttttc cacttcacca 2373661 agagggatat gcacaactcc tgggatatga gctttttcat attcctctat ctctcgaaca 2373721 tctaaaatgt taagagactc gtcactatct actttctgtt tgaaagcttc taatgaaatc 2373781 tcaggaattg aagatgcatt ttctgatgaa tgctctcctc cttttcgaag aaaatgacga 2373841 agtatttctc cctctgcttc agtacccaga tattcatggc ctgtactttt tgcccatgct 2373901 tccagatctg ctgtagaacc tttatctgtc gcatgaattt ccaatacttc accagctttt 2373961 aaatccttca ttctcttctt cgtttttacg ataggcattg gacacgccaa acctttagcg 2374021 tctagtacaa tagttgcttt catcattttt tcctcctttt cttatatagg ggtgggggta 2374081 tacaaatata caaaaagttt ctcactgtaa gttaacacca tgtattcata ccccctttta 2374141 tatttgtgat gtttttaaat ccttgtttct tcaatatttt tacttgcctt taaacttctc 2374201 attccgctta gcaatgagta aatgagtaac attagataaa taagttgaca ctgccttcct 2374261 cagcatctgc caaataagct gctacaccag catagtcaat atcatctaat agttcttttt 2374321 cctgtaaacc aagaagatcc attgtcatcg tacaagctac gagctttacc ccctgttctt 2374381 gagccatctc aatcaactga ggtaaagtaa gtacattatg ctttttcatc acatttttaa 2374441 tcattttagg gcccatacct gcaaagttca ttttagataa acccatctta tcagcaccac 2374501 gaggcatcat ctttccaaac attttttcaa gaaatccttt tttcactgga atcagctctt 2374561 ctttacgtaa agcgttaaat ccccaaaaag tatggaagat cgtcacttca tgatcgtagg 2374621 cagctgcacc atttgcaata atataggctg ccattgcttt atcataatcc ccgctaaata 2374681 aaacaattgt tgtgcgtttt gtttgttctg tcatgtttat tctcctaact aattacccct 2374741 gcgggtatat taaagtcaaa aaattttttc gaaagatctg cttttattca actctttaaa 2374801 taccataggg ggtataatat aacgcatata aaaattcgtc aaccttaggt tgatgaattt 2374861 ttatcggctc tttaccaata agtcgactgc ttcttttact aaattttgtg tgtcttcgcc 2374921 tttttctaaa ctttcacgaa cacaatgttc aaggtttgtg ctcacaatta aacccatcgc 2374981 tcgatcgatc gcattacggg aagctgctaa ttgggtcaca acctctctac aatcttttcc 2375041 ttgttccatc atagtcaata cacctttaat ttgtccttca atccgtcgta agcggttttt 2375101 aatcttttga tcatactcca tatatcaatg aaatcctttc tttcatttat ttttacattt 2375161 acatgttgcc agttcataac tgtttacatg gatacctttg cgctttagaa aacgcactcc 2375221 taaatttaat tccacccggt cacgagctat tatgtgtatt ttatcacgtg gaatctctaa 2375281 ataaaaacgt tttagatacg catatgggat gtttaaaata atattatccg aaaaattggc 2375341 tacatcgtta taatgacgaa tatctaatat tgtgatgtcc atagcctcta atttatcttt 2375401 atggatacaa gagattccgg ttataggata ataacgtcta tacgttgcaa tgataatcac 2375461 aaaaataagc aggaatgcaa taactaaata attgatacta tttacaccac cttattaact 2375521 ctttgtttat tcacaaaaca ataatatacc cccataggta tatagtcaag tgtgaaagtt 2375581 actttctttg agctgataga ttcatttcga tatccgcgga ttgaaaaaat acttacattc 2375641 gataatgcca attctgctaa aaggaactcg aataaagcaa taagccgatt taattttaaa 2375701 tcggctttat ttatcaatta cttaaaatta gcacaagaca cgctgcttgg atattaaatg 2375761 gggtttcatt agcatggtac tggttcccca tgtttcatgc tggatgtgac tttaattatt 2375821 ctagaattct ccagaatatc tgtgctaatc ttccgcagcc actgcatctg ctttggtttc 2375881 atgaactgta ccaaatggat ggttaggagg agcataaatg gagtaaagtt ttaatggcgt 2375941 atttcctgta ttaattacgt tgtgccaagt gccggcaggg acaacaatgg cagaatcatc 2376001 atagacattt ctttgaaagt tcaaatgatc tttgctcttt cccattttga cgatcccacg 2376061 cccctgctca atccgtaaga actggtcaac gttaggatgg atttccaaac caatgtcttc 2376121 tccaatacca agactcatca aagtaacttg aaaatgcttt cctgtccata aagcagtacg 2376181 gaacgtattg ttttgttttg tggctctatt gatatttaca acaaatggtt ttggtccata 2376241 atccttcaaa agaaggtttc tatcttcata tgaagagcgc aaatcggcac ctctgtgtac 2376301 tttctccatc tcatttggaa tagtccaata aacagatctt ccatcattat acatcggcac 2376361 agtcacataa taataacatt gaggcgaaaa agggttatag tacatttttt gatccccgca 2376421 attataaatt tttgtgatag tatcctatgc atttattaag ggagtgtgct aaatcaagaa 2376481 aactcatatt aaacacaaaa atgaatgttc gatcaccgtt tgattcatgg atgaataatt 2376541 tatcaccgac cttgtaatcg ttttctagat gttgaatttc actagccttt gttaacaaga 2376601 catcgaatga cacctttata tgatggatta tcaaaggtcg acgatcctaa atggcttttg 2376661 aacatttaca tagcacaaca acagagtata cggaattctg ttgtttgtcc cccctatccc 2376721 agctctttta gatttatctc tttggatgcg ccttgatggc cagtttttca gcagcataga 2376781 atttatcccc tcctgaatcg ttatagcata tttcaacgcc gatagacttg cggttcccag 2376841 tgccgtttgt accgtctcct gtatgtgggc tcgcttttag taaaccagtt tatattcttt 2376901 ttgggcacac aacagaaaca attttccata tgaaaatctc gtaattttac acctctttaa 2376961 cttgaaggag gatttttgca tatgtatttt catacccgtc aactaccatc tcatccagca 2377021 tatattcctc atatgcattt tcccctattt gcattccatt tctttcaatg aactcaatga 2377081 ttctccggta cgcctcttca gtatttccgc ctatttcata tccaactgca tacaggcctt 2377141 ttggccgtac atgataattt atgttctctg ccccatcttt tacttttata taaaagtaac 2377201 tgtaattgta gaagtctttt tctaagattt gttcccgtgc aaagattccg cctatcggat 2377261 atccttcatc taattcatat tgctgaactt catgaatgag ttctgaaatg gctgccacat 2377321 attttcgttc tggtaagttt aatgtttttc ggcttaacat gaatgtttct tcatttaaat 2377381 attcaaaaga aattgaggaa aaatcagtct caagtgcttg ttctgtaagc gtcacttttg 2377441 tttgtaagat cgtttgcaac tgcttaagct catttatttt tttatcaatc tcaatagact 2377501 tttcttttag aacatgcagg atcttgtctg gtgtttttcc ttttattaga cactttattt 2377561 cttttaatgg aaccccaagc tctttaaata gactgatgac ttgaaaagtc tcaaattgat 2377621 gataggaata atatctatac ccattttctt tttttatttc cggcgagaaa agaccaatct 2377681 catcataatg aaataaagtt tgttttttta cacggcagag cttcgaaaac tcccctgttg 2377741 tgaaatactt cttaacatct tcgctcataa aaacctcctt gactatacgg taaccatata 2377801 ccttatgatt tgattgtact tgaaaaaagc ttcaagcgaa aaggataggt aaaaagggtt 2377861 caattgagta aaaggggaat tcagatgaaa aaatcaataa atgagcaaaa aacgatattc 2377921 attatactat taagcaacat cttcgtagca tttcttggta tcggtttaat cattccagtt 2377981 atgccttctt ttatgaaaat catgcattta tccggcagca caatgggtta tcttgttgcg 2378041 gcttttgcca tttctcagtt aattacttca ccttttgcag gtaggtgggt tgaccgtttc 2378101 gggagaaaaa aaatgattat tctcgggttg cttatattca gtttatctga gttgattttc 2378161 ggattaggga cccatgtttc aatattttat ttctcgagga tattgggtgg tgtaagtgcg 2378221 gcttttatca tgcccgcggt aacagcatat gtagctgata ttacaaccct aaaggaaagg 2378281 tcaaaggcta tggggtatgt ttctgctgca attagcaccg gctttattat tggacctggt 2378341 gcgggaggat ttattgccgg ctttggtatc cgcatgccgt ttttcttcgc ctccgccatc 2378401 gcgttaatag cagctgtcac ttccgttttt atactaaaag agtcattgtc gatagaagaa 2378461 cgccatcaac tctcatctca tacaaaggaa tcaaatttca ttaaagactt gaagagatcc 2378521 attcatcctg tctatttcat tgcatttatt atcgtctttg taatggcttt tggtttatca 2378581 gcttatgaaa cggtattcag cttgttttct gatcataaat ttggcttcac accaaaagat 2378641 attgcagcca ttattacgat tagttccatt gttgcggtag ttattcaagt tttactattc 2378701 gggaaattgg tcaacaaact tggagagaaa agaatgattc agctgtgctt aataaccggt 2378761 gcgatcttgg ctttcgtgtc tactgttatg tcaggatttt taactgtttt gcttgtaact 2378821 tgttttattt ttctggcgtt cgatttgcta cgtccggcct taaccgctca tttatccaat 2378881 atggccggta accagcaggg tttcgtagca ggcatgaact ccacatacac cagcctggga 2378941 aatatatttg gacctgctct aggcggtata ctatttgatc ttaacattca ttatcctttc 2379001 ctttttgcag gtttcgttat gattgtcggc cttggtctta caatggtttg gaaagaaaaa 2379061 aagaatgatg ctgcagcttt gaattaattc attttctata aagttaagtc atttggatgc 2379121 agggaatgcc cctggttagg cacaataaga aaaggtactt aatttgatag gctacatgtt 2379181 gcttgacgtg aatatagtat aagctgagtt ttagcaatat caggataccg ggataagaaa 2379241 aaaggagaat gtagtatgag tataaacata aaagcagtaa ctgatgataa tcgtgctgca 2379301 attcttgatc tacatgtcag ccagaatcaa ttatcatata ttgaatctac aaaagtatgt 2379361 ttagaagatg caaaagaatg tcactattat aaacctgtcg ggctttacta tgaaggagat 2379421 ctagtcggtt ttgcaatgta tggattgttt cccgagtatg atgaagataa taaaaacgga 2379481 cgagtctggc ttgaccgatt ttttattgac gaacgctatc agggaaaagg attagggaag 2379541 aaaatgctta aagccctcat tcagcacctt gctgagttat ataaatgcaa gagaatttat 2379601 ttaagtatat ttgaaaataa tattcatgct atacgccttt atcaaaggtt tggttttcaa 2379661 tttaatggtg aactcgactt taatggtgag aaggtaatgg taaaagagct atagatatcc 2379721 aagcctcctt gtttgctgag aaacgtttga acttcgataa tgattaccta cttaaactgc 2379781 aagatcattg tttaaaaaag cctggatgaa aatttcatct caggctttaa gcatcttatt 2379841 agtcaaaatc tcatgtgttt tatccagatg ttattctttt ttccggacaa tttctaaata 2379901 attaatatgc cggccaactg tttcgtgcac tttaaaaata tacccatcgg cttctataac 2379961 ggacccaact gcagcgtcta tttgttgagt cataaaccag ccgcctattg tatccacttc 2380021 gtcacttgct aacgtcgttc ccaataaatc atttacatct tcaatgagca ctttcgaatc 2380081 taagatatag tgattatcat ttacttttct aatattaggc acttcatctt tatcaaattc 2380141 atctctgatt tccccgacaa tttcttcaag aatatcttca gcagtgacta aacctgaagt 2380201 gccgccatat tcatccacaa gaatagcgat atgtgttcgc tctttttgca tttttaccaa 2380261 tacatcatga attggaacgg attcaataac atggataaca gggttgatat gattttctaa 2380321 cttgaaatcc tcttttatct tctggtctgt gtcaatataa gctgacaaaa attctttagc 2380381 attgataaaa ccaatgattg aatctttatc tccatttagg actgggtacc ttgtatagct 2380441 ctctgtctta atgatcttaa caatagtttc ataagaatcc tcactagaaa tcgctacgat 2380501 ctctcttctc ggaatcataa tttctttggc gattctttca tcaaattcaa aaatattatt 2380561 tacatatttc aactcatttt gattgatttc accgctctta tagctttcag acagtaagat 2380621 gcgcagttct tcttcagaat gagcaagttc atgttctgat gcaggtttca aaccgaagag 2380681 tcctactata aaccgggctg aaccatttaa aaaccatata aaagggaaca ggatgcggta 2380741 aaaccaaata attggctttg cagtcaaaag agtgatggtt tccgcttttt ggatagcgag 2380801 tgttttagga gcaagctctc caactacaac gtgcaaaaaa gtcgccatca caaaagcaat 2380861 cactaagatc aatacatgtg agactgtttc acttacatga aaatgagcaa ataaggggtg 2380921 caaaatcact tcaaaagtcg attctccgac ccagccaatt cccaacgctg taaccgtgat 2380981 ccctaattga caagctgaca aatattcgtc caaatgagta atgacctttt tggctgatat 2381041 ggcacctttt tttccctcta atatgagttg gtcaattttt gatgacctga tctttactat 2381101 cgcaaattca gtcgcaacaa aaaatgctgt taagacaatt aaaagagtaa agattataag 2381161 gttaatggtt gtcaatgatt tgccttacct agtaaggcgt acacctccga tgtaaatatt 2381221 tattgaataa acaaaaaaca gtatatataa cattataagt tcaaaagaac ctaaaatcaa 2381281 ctctgaatga tgtaaataat catctttttc cgtatggaga gtggttccca tagtcttcaa 2381341 ctaacgatta gtggcgtttt aaggcttaaa aaagaaagca aaataaaaac acacctgaat 2381401 tttctggtgt gtttcaataa tacccaaccg tcttgattta tttaatgtct ttataaagat 2381461 tttcttttaa aatttgaatc aattcggcct gttgctttat atttttgcgg ccatttctat 2381521 taattgcagc aagttcacag acaattccag ctgaaatgaa aaacaataaa ccttcaaaca 2381581 ttttaaatcc cccactgtct aagtgatagt caaatttgtt ttttcttttt gcaatacctg 2381641 cttataatct tccttacgct gatatatgtt atttaaaatg agtccaataa tgacaaacag 2381701 tgttcctact atatcaaaag cagttatgtt atatcctttg atcaccatga ttaacaatgt 2381761 agtaatgggg acaaagttaa taaataaaat cccattaatg gatgatagga ttttaatgcc 2381821 atagttccaa ctaaggaggg ctatgatacc tggtaaagta atcataaata aaaaatcata 2381881 cttaattgct gcaatcactt taatactcgg taccgacacg taaccttgcg cggtaagtat 2381941 agctgtcatg attcctgtta tagctgtgcc gaataaacat gtcaaagttg aataacgaag 2382001 tgtggaccac tctcggaata tctgtccccc cattgtgtag acaacccacc ctaaaacacc 2382061 aatgaatata aagagtatcg agaatagatg atcccctaat gaaaaaaaga aacttatatt 2382121 acctttggtt atgaccatcg aagcccccaa aaaggcaatc aatatactga tcattgtgta 2382181 ttttttaggt ttcacatgtt tatatcccca tagaataaca attgaaagca tcggcatgag 2382241 tgcctcggca atggatgctg tcataattcc agacttcccc atcaaccttt gacctaaaaa 2382301 aataagaaca ttgtatatag taaacgccat caccccaaat aaaatgatcc attttgcttt 2382361 accctctaaa tgaaatgatt tctttccttc tctcaccaat aataaaatca ctaacataat 2382421 cgttaccaca ccgtagcgaa taaatgaaaa ataaaacgga tcaacaaatt ctaatgcatg 2382481 atctgcaact ggaaacatcg cgccccaaga catacttgct actaaacatg taagggcacc 2382541 aatgaataat tgaccttttt tcattgaatt cccctccttt tctttaaaat tacaatgaga 2382601 attataaaaa gaagtaagca tcaagtaaaa tgaacaaaag tgatgaaaaa catcattgat 2382661 aatgatactt taatgaaggg gggatcttca tggaactgcg agacttacaa attttcaaat 2382721 gcgtagccca tcacaagagt attaccggtg ctgcaaaaga gttaaattat gtacaatcta 2382781 atgtaactgc gcggattaag caattagaga atgagctcaa aacacctctt ttcaatcgcc 2382841 ataaaaaagg ggtttcacta agcccagagg gccgaaaaat gattgaatac gttaacaaaa 2382901 ttttgaaaga tgttgaagaa ctggagcaag tctttctaga tactgaaata ccgtctggaa 2382961 tattaaaaat cggtacagtg gaaacagtga ggatactgcc gaccatcata gcttcctatt 2383021 ataaaaagta tcctaatgtg gatttatcat tgcaggctgg tctaacagag gaacttatta 2383081 aaaaggtcat gaatcacgaa ttagacggag cttttatttc aggccccttg aaacattcta 2383141 ttctggaaca gtatgatgtt tatactgaaa aacttactct tgtaaccagt aacaaaacgt 2383201 ttaatataga ggatttttca acgactccga ttcttgtttt taaccagggg tgcgggtatc 2383261 ggtctaggct tgaacaatgg ctcaaagatg aaggtgtgct cccaaacaga atgatggaat 2383321 ttaacatcct agagacaatc ttaaatagtg ttgcacttgg actcggtata acagtggtac 2383381 cggaatctgc tgttatgcat ctagctgtac aaggtaaggt ttattgccac ccattgcctg 2383441 agaaagacag ctgtatctca acaattttta tacgccataa agatgcgtac ctgacaaatt 2383501 caatgcgcag cctcctaaag accattgttg aacataaaaa tatgagtatg gcttaaagtg 2383561 atttttctct ttctatattc taacttctta aataaaagag aaggctcatc tccacttcgc 2383621 tacccttatt cacgcaaaaa atagagcagt aaacatgtga gttactgctc tgcttcgttt 2383681 attcaccgtt catttgtttt acaatgtatt cagcatcatt tcctacgcct tgaagcaacg 2383741 ctgaacctcg cttatgctgc caaggcaaac ctataaagta caatccttct acaggtgaaa 2383801 cacctctatg atgtatgatt cgaccttctt gatccaaaac accttttata tttatccaac 2383861 ataagggatt cctgaaacca gtagcccaaa taatattgtt tacttctaat gtagatgaat 2383921 ctttaaaaat gatttcattt tgctttgcgg caatgactct tttttttaag atgatctcct 2383981 tctgttttat tgcatgtttt aattcatgcc caaatactgg atcacctttc ttttgaatga 2384041 atttgcctac tattgatgta tgacttgcat gtaaaactcc tagtttatca aaccaccaaa 2384101 agatgcttct ttttccgatc attaaaggga aataaacaag tttattacta caagctaaat 2384161 atgtaactct ttctttggat aattcaacag ctatttgagc accactattc ccaccaccaa 2384221 ctactagtac atttccatat gccaattgtt ttgaattctt atattgtgat gagtgtagtt 2384281 gattaatatt atcggataaa tcctttgata ttgatggaat attaggggta tgaaaaggcc 2384341 ctgtagcaat gacaagattc ttcgtttgat attcttcccg atttgttttt attaagaaat 2384401 aattctttat ttttaggaca cttattactt ctgtccgtaa ttggattgga atttcaaatt 2384461 ttttaacata cttctttaga taagcaacaa tttcattttt tgaaggaaat ccatgttttt 2384521 ctccttcaag atgcattcca ggcaaagagc tatacattcg agaagtaaat aaaactaatg 2384581 agtcataccg atctttccag ctctccccca cctcatgact tttatccaaa atgataaact 2384641 tttgatcgga ctgcttaaga taatatccta ttgagatccc tgcttgacca gccccgatta 2384701 ctatagtgtc gtacacatta tcaccccgcc aatttcaaat tgtcagtaga cagaatctgc 2384761 aaaatcctag ttgatctcct cactataaag ttagataaaa aatttaatgg tgatggtggt 2384821 cacgctgctt ctccattttg ggctgacaaa ggatcgcatt gtcgtggtta tgcgcttcgg 2384881 tttccatttg aatggttacg tgcgtaatgc ctttatgctc aagttcatgt tcaattttgc 2384941 gtaaaatatt ttcactttct gaaatggtca gttgatcgtc aacaactgcg tggcaagaaa 2385001 gagcattcaa tccgcttgtg atagaccata tgtgtaaatc atgaatgttt tgaattccct 2385061 ctgtcccttc aattgtacga atgatatcag agacatcgat attttctgga gttccttcca 2385121 ttaagatgtg aatggaatct ttagtcacat tgtaaccgct tcttagaaca agaatagcca 2385181 caatgatact agccaatgga tctgcccagc cccatccaaa gaagatgata agtatggcag 2385241 ctaaaatggc acctacagag ccgagcatat cgcttattac atgtaaataa gctcctctta 2385301 tattcagatt attctttgta tctccgccac tcatcataat ccaagcgacc aatagattca 2385361 caactaaccc gatgatacta attgtaagca tgccggttgt tgctactttt ggtggattag 2385421 agaagcgttc gattgcttca taaatgatat aaagagaaat aagaattaag gcagcaccgt 2385481 ttatcacagc tgcaagaatc tcaaatcgtt tatagccgaa tgtcttattg tgatttgcct 2385541 ttttttcagc taatgtaaaa gcaatcaggg caaccattaa tgaaattgaa tcactcagca 2385601 tatggcctgc atcagataaa agcgccaggc tatttgttaa aaatccacct atagcttcta 2385661 taatcatata acctgtaatc atgataaaag agatcaataa aaccttttta tttgctcctt 2385721 cattatgatt gtgacccata aaaaactcct ccttacctaa agtttttaat acatatgtat 2385781 ttattatttc aaatctgtta tgaagcattc taacatgata caaataatat ttatatatga 2385841 gcatgtgttc atatataaat atatctgctc tttactgaaa tgtcaaaata tttttataga 2385901 aatccacaat acctccttaa ttattctttt ataaacataa aaaagcggag caaacacatg 2385961 gtttgctccg ctaccctagt ttctctatcc ttttcttcaa tcaagcattt gagggtagta 2386021 ttcaactaca atttacctgt taaaaattgg gcctcaccaa gtccaaaact ccagtcagca 2386081 ttatcatttt caacaataga tacaattaaa tcagttgatg cgataccaca ctcagattcc 2386141 agtctttcag ctaacagcct gtaaaatttt tgtttcttct cttccggtcg ggatttactt 2386201 gtaactgaaa gaacaacaag atttttagtt cggttaaatc ctaacccagt atcctcaata 2386261 atcatatgat tttctggatg ttcatgaaca atttgataac ggtcttgttg aggcacatca 2386321 aaagcctcta ctacaacatt gtgagcgaca tctaaaagtt ttttcaaact tgattgatct 2386381 cgcccttcta ttaagtcaaa acgaagtaat ggcataaaat cccctccttc tactacaaca 2386441 gtctttttaa tttcattcgt taatgtgtca gctatttcca agcagctgct acatttagaa 2386501 aataaagtaa tttcccaata accccttcat tctggtgtta gtcaagccta tgttatgatg 2386561 tgtatttcca taggcaatat acagaatcaa cttcgagtaa ttaaccattt tttgaaatag 2386621 ctttatcact tactttagaa atcatttatt cttctaagct ttagtttaca tgaagctctg 2386681 ctatcatata taattcaaaa ttaagatgga agacatctca aaatcagata tcaactatgg 2386741 aggactagat gaatattcag ttgttacagg tttttctcac tactgctcgt gaaggcagta 2386801 tttccaaggc tgctctgact ttaaattatg cacaatcgaa tgtaacgaat aagatacaac 2386861 aactagaaaa cgatttacag acaaaattat tctatcgtca tagtcgagga atcacactta 2386921 ctcccccagg gcaaattctt gtttcttact cagagaaaat tctacatact attgaagaag 2386981 ctagagcagc catgggcgaa tcatccgcgc cttctgggcc actgcgtata ggatcaatgg 2387041 aaacaacagc tgcagtttgg cttcctcaac tccttgcaca ttataataac ctctatccaa 2387101 atgttgattt gaacctagta accggcccta cggaacaaca aatacaagca gttttacatt 2387161 atgagttaaa cggcgctttt atttcagggc ctattgaaca ccctgattta gttcaagaaa 2387221 aggtattgga tgaagagatg gttcttgtta caagtgcttc acaccctgtg atttcttcca 2387281 ttcaggatgt tcaaacacaa acaatgcttg tattccgtaa aggatgctca tacagagcaa 2387341 agctcaatca tatcctgcaa gaagaaggtt tattacctat aaaattaatg gaatttggca 2387401 tacttgaagc gatcattggc tgtgtaagcg ccggcttggg gatttcactg ctgcctcgtt 2387461 caatcattgc ttcgcatgaa aaagaaggcc gcatccgcag ccacactatc tctgacaaat 2387521 attcttttgt atcaactatg tttataaggc ggaaagacac tttaattacc cctgctttat 2387581 ctgctttttt aacgcatatg agggatcatt ttcagataaa gaggccagat caatcgtaaa 2387641 taaatggatg gaaggcatgc ttcgcctcaa aatacccctg atcagttgtc tgatataaaa 2387701 atataggcgc atctcaatgt ttgtatagag caaaaaagca aacttcggta tgtagtttgc 2387761 tttttcttcg tgattttgca ctctgaatcg tgaaacctag tcgatattag gatgtagatt 2387821 ttcctcattc aaagaatttt gaacgaaggt cattgcccta gacacttggt tgcgtcttga 2387881 agttaaaggc tgactatttc ctaaagcgtc aatcgctctc acaactatta aatattcacc 2387941 tacagatttc gggtgacaac gggaagattg atattttcgg ttggacaggg gcagaacatc 2388001 caattgtaac agttgaagta tccactgatg gaggagatcc tgcagatctg agtgatattg 2388061 ctgttgattg atcaacttgt ttttgttcgg aatatactca gtatatagcc gcatattcct 2388121 cctgcaatag ctggaatgag ccaccccagc cctatgttat acataggaag aatctgagtg 2388181 aaaatacgat tcacaacttc aatttttatt ccagccgcct tcaaaccgtc aaataggctg 2388241 atgatgaatg cgaataataa actgccttga tacacttctg tcttcccttt aaatacagaa 2388301 tgcaaaaacg ttaaaaatat taaggaaatc gcgataggat acatcgtcag taagacaggc 2388361 attgacacct taatgagctg ggttaatcct atatttgcga caagcgtact aaacactgat 2388421 aaaacgacag caattttttt ataagaaatg ttcggaaata attcatgaaa aaatgaagaa 2388481 cacgctgtga tcagcccgac acttgtcgtc agacacgcca ctgtaatcat taagcccaat 2388541 aagattgaac cataagatcc aaaataatag gatgaaacct tagccaaaac ctctgctcca 2388601 ttttctaaaa tccccagttc ttcaacgctg gaagccccca tataggaaag ggctgtatac 2388661 ataactgcta agagtacagc tgcaatcgcg gctgcttttg cacaaacaac tatcagctgt 2388721 tttttggtag aagctccttg ttctttcaat gcattcacga tgataattcc aaaaacaaat 2388781 gctacaaggg catccagagt gaggtatcct tcctgaaatc ctttaaaaaa cgcttgtgat 2388841 gtgtaccctt ttgatggtgc ttgaatggtt ccaattgggc gaataagagc tacggctaca 2388901 agcaatccga taaatgtcag cttaattggc gtcaaaaatt taccaactat atcaatgatt 2388961 tttgaaggat tgagtgataa caagcatgcc aatgcgaaaa ataatattgt aaatatgatc 2389021 aatgagacag ggcttgcatc atttgataaa aaaggtttta ccccaatttc aaacgatacg 2389081 tttcctgatc tcgggatagc gaaaaaaggc ccgattgcca aatagagaat cgtcgtaaat 2389141 acaatgccaa acaccgggtg aacacggctg gctaacgact gtaagttttg tttacccgaa 2389201 aaaacaaatg ctgttatagc cagtaatggc aatccaactc cggtcactaa gaaacctgca 2389261 ttagcgaccc atacattttt cccggccaat tgaccaagca taggcggaaa aatgagattt 2389321 cctgctccaa aaaacaatgc aaatagcatt aatcctataa tgatgatata ggaagcagac 2389381 actttttttg acattatata tcctccgatt aaagtagaca cttcttgaat agccaggaaa 2389441 cattacagat gctatttgca ctggcacagt gttgattcca aaataagctt gtgtcagttt 2389501 tatatatttt tatcaagtta aataaaagca tgatcatttt gatcgtttcc gatatcggtt 2389561 aaaaaaccaa ttgcaccaaa accatataaa caacggttcc ccccgctatg gaaagaagca 2389621 tatttttctt ccacaagtga agcagtacaa cagcagctgc tccaaccaat tcaggaatgc 2389681 catgacttcc agaaagtaga ctcacatctt tcaaacaata aatgactaaa agcccgatta 2389741 ccgctgatgg cagcacttta ccaagatact gtacatattt cggtgtcggt ttgccagacg 2389801 ggaaaatcat gaatggaagg aaccgtgtca gcattgttcc aagcacgacc attgcgatgg 2389861 tgatcatttg ctgcgtcata gtcatcgtca tacggaaacc tcagctttct ccaatggttt 2389921 tctcagaaca gtcagtaccc ctaaaatggc gagcatagca ggaataataa attggtttcc 2389981 gccaaaaagg ataagactgg ctactgaaag tccaagtccc gtgagagcac tgtaatgctt 2390041 tttctctttc atccattgtt ctatgaatat cacaataaac agagcagtca tcacaaaatc 2390101 aagcccttcg gtattaaact tcacgtacga cccaaaaata cctcctatcg ctgcccccgc 2390161 gacccaatat aaatgattaa gcagtgtcac aaaaaacata aaccagccct tatcaacatt 2390221 cgccggaaca ttagcggtat aattgataga aaatgattca tcgcacattc cgaaaatcag 2390281 ataaagcttt ttctttccag tccccctgta cttatccaac atggaaattc cataaaacaa 2390341 atgccgggca ttgaccatta acgtcaaaaa aagagcattc atagggttga acgcaccaag 2390401 taaaaaattc gctgcaacaa actccattga gcccgcaaat atcataaaac tcatgatgat 2390461 tggatagatt gcgctaaatc ccaaagaatg cataaagatc ccataagcta tccccaaaaa 2390521 taaaaacccc gcaaaaatcg gaatggtata tgggaatgca gaacgaaatg cagcccatat 2390581 ttgacttctc ttattcatat gagtgtttat agcaggagag cttaaatgta acgattcttt 2390641 atttttattc aaatcaacaa cctcctacat ttcatcaatt ggcacactga cagttctttt 2390701 ttctgtactc atgactatgc ttgtgtcaac tccactaata gcagggttct gcattaatga 2390761 atcaatgata aaattccgat aactctccat gtccttcgcc acaatcttaa gcatatagtc 2390821 atggcttcct gtaagtgtgt agcattcttg aacctgtggg aatttgttta tatcctctaa 2390881 aaatgaatga attgtctccc tatttaaggg tgataagttg atgagagcta gtgctgtgac 2390941 ttcgattcca agttttttct catcaacaat agtcgtaaac tttttaatta tacctgcttc 2391001 tactaggttc tttgttcttg caaggcaagc tgatggtgaa agcccaattt tcttagataa 2391061 atttaaattt gatattgaag catcttcctg caaatctctt aagatggcct tatcagtttc 2391121 gtcaagcata atacccattt cacaaccccc aatacaactt aacagaatta tatttcatac 2391181 aatttaaata ataacgaatt tttattcgtt aatcaaatat tatttaaatt taaatccttt 2391241 taaagtatta ttcacagaat aaaattatcc tcgcgattaa ctcataatga aattaactta 2391301 catcagaaag aagtcatggg agagttatgt acttgtgtga cttgatacca acatcataag 2391361 aaacttatca gaagccaaaa agttattgcg gtctcaccga aaattgaatt tgcggtgccc 2391421 tattgccttt ttccgcgaac gaaaattgtt aaaattcgca aaacagaaag tctactctat 2391481 tattatttta aattcgtcct ttagttcttc ttgagcctct tgtataactt ctaatacatc 2391541 gtcagcgtat gaacctaaaa atgtattgct gaactcaaaa tttttcaaga ctaaagtgag 2391601 cggcaaatcc acccaccctg tcaggcaatc ccataaagcg tctaaatttc tcccatagta 2391661 gtctgggaag tctagtttat cttttaaatc atcatgtaaa acttctatat tttcaaagtc 2391721 tcttccatct attattattt ttctcattag aaactatgcc ctccattatt ttatcttaac 2391781 aaacgtttac tatgtaacag ctgtttgtcc aaatgaggct gaaaacaaat aaaaaacacc 2391841 gataggatga aactattggt gtttgcaaga catcttcata cccggtaggc ataaataatg 2391901 ctaaactttg tttttaaaaa gctatcatat caaattttta tgttacagct tttactatcg 2391961 tttaatctaa ttgaggagta aaacaagata tgtttgaaaa tcacatatcc cctaaaaatt 2392021 aaaaactaat cggcagttct tcgagtgctc tcatcagaaa attccctttc catttcattt 2392081 gtttcttttc gccttttaac tgtatatttg gacagcggcg taataaggtg gaaatcgcaa 2392141 tctttgcttc taagcgggct agctgtgcac caagacaaaa atgattgcca tggccaaaag 2392201 caatatggcg gttgttcttt ctttcaatat caaatatgtc ggcatttgga aatatctttt 2392261 catcacggtt tgctgatgct aaagaaatga tgatcacatc tttccgttta atctcctgcc 2392321 catgcagtat aaacggttca gccgtccagc gaattgtcgt tagctcaaca gggctgtgaa 2392381 accgcaatgc ttcttctatg gctgaattca tcaagtccgg ctgctggcgg agcttttcta 2392441 gttgatcatg gtgacacatc agagcatatg tcatattggt gattaagttt acggttgttt 2392501 catgacctgc aacgataagc agcataatca tcgagtacaa ttcttctgta cttaattgtg 2392561 tgccttcact ttccgcttga attaatgcac tgattaaatc tcctgcaggt tctctccttt 2392621 ttttgcgaac taaggattcc agatattcaa caaactcccc taacaagtgg tcattctcct 2392681 gaagtctttc aggggcatct gaaaaatcaa taattgcttg cgaccatact ctgaattttt 2392741 gacgatcttc caagggaatg ccgagcattt cacttatcac gataatcggc aatggaaacg 2392801 cataatcgtc tactaggttc atgaatttgt tgggctgcac tttatccaat aaagaatctg 2392861 cgatatgctg gattttgtct tccaactgca aaatcatccg atgcgtaaat gctttttgaa 2392921 caagagttcg caagcggttg tgatcagggg gatctgaatt aagcatatgt tttgttaaag 2392981 tctcttcatt cttcaataga gcaggacgtt tttcttttgc ggtaaataca ttttcatagt 2393041 ttttctttaa tttttcattc tttaataaat gtattgcatc atcatatctc gatatgagcc 2393101 agcctttccc cagagctcct aaagataatg ggtagagagc ctgtgatttt cgcaattctt 2393161 tataaaattc atacgcttca tctttaaatg ctctcgaaga caattgactt tccgtcaaaa 2393221 tggttacact ctttttttct tttgaagaca ttcattcgac ctccatcttt gaaaggttat 2393281 gataatcttt aaatataaaa tcaggacgat ttgtaaaatg atccattgag atcagtattc 2393341 atgataaggg ccaaaatgcc gtccccgcat tttgaaataa aagatatgag acagtcatta 2393401 atcattttgc tgcctaaact ctttccctga taaaatggcg aaactcctaa tacttctatg 2393461 ccggctcttt taaggatttg gaaaattttt tagccccatt ttgattaatg ttatcccccc 2393521 tgctgctata taatcgatca agtttaatgt cgggtttatc acgatgtttt aatagagcgg 2393581 caacaaccat ttcaccattc tgaatgccaa caaaaaagaa atgcttttta aaatatgctc 2393641 ttgtcagtac tttatgcatt tcaaaaataa atgaatgatc tttttttcgc gttttacgag 2393701 taaatccata aaaggatatt gattgaaaga ttgatggaat agctttgcca ctttgcttac 2393761 ttcatctgct cttgcttgtc gataaagaaa cattgatgca cctcctctga gcagtaaagc 2393821 aggaaatcga attaaagcgc ccttcctatt ggaaaggcgc ctgccgtttt actgtgccaa 2393881 aatgtttttc atcagtgagt ttttataaaa tcatttatta attgatcagt tgtcaatatt 2393941 gtggcaaatt catcatgcaa tgtagctaga gatatattat gaatagtcgc cgcatcataa 2394001 tatgtatcat tttggtctct cattccgaag gctgctgttg catctgaaat caggtatgta 2394061 tcaaacccta aattaccact cattcttgtg gtggttgata cacagtgagg cgtggttaaa 2394121 ccagttatga ctacagtggt tatttcattt aattttaaga attcttctaa attcgtacca 2394181 ataaagctgc tatttactgt cttggttata atgacttctt catccatagg cttaactatt 2394241 tcctttattg caaacccttc attctttgga tggaataaag aatgaggttt atcagaagtg 2394301 tgttgtatgt atatgactgt ccatcctttt tctctccata attctagtat tttactaatg 2394361 ttttcttccg cctttacgtt attccgttcc ccccattttt tatcatcgaa ggctttttgt 2394421 acatccacaa tgattaaagc tttcttttct tccacaagat accctcctac gtagaatttc 2394481 tatttattac tacattctaa atacaaattt tacttttgta caattgttta atgatgaatt 2394541 tcaaatgagc gccttcttta ttggaaaatg cgttctatac tgcaactgtg cccaagccgt 2394601 taaccttcaa atctaatctg agaatcactg gctctacaga gaataataaa aaacactcta 2394661 ataacgagtg ctgaaatgaa aaactattga tttagaagcc atttgatacg ctcagctgaa 2394721 atgatgtagt ggagtattat aagacataaa aagacaatac taactggttt taaataacta 2394781 aaataaagcg ctgcaacagc cattgcaaag atcaataatt caataactaa ccttgttact 2394841 ccgtttacag ctattacagt ttgtccgctt cgactaggat catgaggtac tgcaaataca 2394901 gaccagacaa tcataactgc aataggtaaa accaaagtta aaacatattt aaaataacca 2394961 ttaaagctta tccaagcata cacccctaag gagattagtg cagcaatttc aagggtgaat 2395021 cttaaaagta aattagtctg attcagtttt tccaactcct ctataaaaaa cacccccgca 2395081 ggagatgctc tttctctgct ttatttcagc gtataaaaac ttttctgttc ttcctcttta 2395141 gattctattg tagttttcgg cgagattacc tctacttttg aagagatgat accgactgct 2395201 gctgttacca atgctccgat aatagaacga tgataagtat aatgaaatat gacaactttt 2395261 cccctcctat tcagttaatt atccaaataa tcaggaagtt gtctacaatt tgcagaattt 2395321 gtcgaacgaa gtaaagatta tacctgggag gctttactca ttgtatgaat tacagtaaat 2395381 aaattgcctt cccttttgag aagacgttcc aactcagcta gactcttcca ataggcttcc 2395441 ttttggcgca gctgctttta ttcaaaaatt gagcaacacc tgaatgtttc attggaattt 2395501 ctgaaccatc gatcgctgct gaatttgttg caaatgcata cgtaggagta gtcgaatggt 2395561 ggttgaaaaa tgaaatgcct tccccacctc gagtgatggc agaaaaagcg ggggttttgt 2395621 tagagaggaa tctatagata tgtgtatcga agatttgaca gcattaaaaa ttatacttac 2395681 atcgttggga acaggccaac aataaagcgg aagaacgttg tcatttgaag tggtttggaa 2395741 taaaaatgat tcgaatatgt tcttatcatt gtaaacgaac aaaaaaagaa catgttttga 2395801 aaaaagattg atcaaaacat cttcttatat gttgtcatag cgtaactttt tataaaaagg 2395861 ttaattacat tttcggggct tccaaaccaa attttgccca ttcttctttt gctggaccat 2395921 aaatacctgg aacagttaaa cctgcttgtc tcataagaac agtcatttgt ccccgatggt 2395981 ggttttgatg ttgaattaaa aacatcaaaa gtgaaccgtt aggcatttgt tgtccaataa 2396041 agttgatacg ttcttgaagt gtatggtcag tccattgggt ttttaatgcc tgtacaaatg 2396101 cattactggc ttgatgatag ctgtcagcta taaactgagc agaagttgga acaggataat 2396161 cttcagctgg ggcttggaac gttaagtctg tgtttgaggt aatgatgcca atggcagcaa 2396221 cagtatgcca agcaatacgg cctagagtcc aattttgtga agttatttct tgtttaagtg 2396281 attcatcagt cagactattt aatagtttct gtgtagcatc tgcttcgaac tcccaagatt 2396341 tcaaaaaatg gtctaaggtt tgaaacacaa aaatcctcct tttcattctt ttgttttttc 2396401 aatgtgctta taggttaatt ataatgcctc ctttcgttaa aaagaacaaa aatttcggac 2396461 aagaataatc atagtaaaat gcgtagacat tcttaaacgt aacgatttac gcatcttttt 2396521 acaaacatct gactacttgg tctccattgt cagcgagaat caaatatcat atgaagacaa 2396581 tcctatattc ttatcacttt actgagcaat aaataccttc cgtatactta gtaatacctt 2396641 catcgtaatc aggatactta tatgcaagac cttctgatac agcttttgaa tactttctaa 2396701 ataatgcata gcaagtaaat aaagacttcc acatttcctg atacccattc acagaatatg 2396761 tagacatgag ttcctcccat tctttatttg aaaggtaccg cttcataaat ttatagttct 2396821 tccccatact aaatgaatac cctttctgag atgcgatatg ccaggccatc attctcaata 2396881 aattaggacg tacaatttca tttaaatggt caatggcaaa aaggatttca tttcttgcta 2396941 gtccttttac tacgtaagtc gaaaccatcc agaactcatt acagcaatca tcaaattccc 2397001 ttgcagtcgg cctttttatc cagtattggc gatcatttgg ggtcacttta tagttgatga 2397061 acgaatcctt atcaagcaat accttaacca aaccatcgtt attagcaaaa taatcttctg 2397121 cttcacgaat tggaataagg gttagatcta atttgttgcc atcctcaaaa agaataatgt 2397181 atgaaaacca attacctaat tcgggaggaa aaagctccat atcttctggt ttttgcatca 2397241 taatgcgctt cccaaagatt tcgagccact gatcattttc tttaaaagat tctacatcag 2397301 ttacaaaata cgagatgtca taatcttgga agttgtcagg agggatattt ctgtttgtac 2397361 gtgacccttc caaagtgacc aatcggattc tctcatcgtt caaagcaaag tccaaaaaaa 2397421 tgtccatcat ttcctgctca cttcgcatta catgttcctc cgtttcagcc ttaatatcta 2397481 actgtaaaac gtcttataga tttttttact cttgaatgtg atgtattctt ctaagcttta 2397541 ttttacatga tgttctccta tatatcattc aatattaaga tgcaagacat ctcaaaatca 2397601 gatatcaact atgacggact acatgaatat tcagtttttt gtagagccgc catgggacga 2397661 cactatcttt gacacacttt aatcccccct gctttatcga catgttaact ggtatgagag 2397721 attgacaaaa agaaggaaaa cgatatattt aagcgaatac gagtttttga gtaaatttta 2397781 aaatgacact tttttcaaaa atcatgtctt aacgggagga ttcggtatga atgaatttat 2397841 gaaaaagttt tctttaacaa aaccgattat tcaagctcca atggctggcg gtattacaaa 2397901 gccccgactt gcatctgcag tttcgaatca aggtgctctt ggcagcttag catcggggta 2397961 tcttacgcca gacctcctag aacaacaaat aaaagaaata tttgagctga cagacgctcc 2398021 ttttcaaatt aatgtgtttg ttccgctagg tctagagatg ccaccaaaag atcagattaa 2398081 aaagtggaaa gaaaacatac cgttagctaa tcaagtaaat caattcacat ctgtacaaga 2398141 agagtgggat gacttctatc aaaaaattga tctaatttta aaatacaagg ttaaggcttg 2398201 ctcattcact tttgatctgc cgcctgaaga cgcagtaaag gagctaaaaa ccgctggatg 2398261 ctgtttaata ggaaccgctt caacagtaga agaagcattg ttaatggaag aacggggaat 2398321 ggatatagta gtccttcaag gaagtgaagc cggtggacat cgcggagcat tcttaccttc 2398381 caaaggtgaa tctgccgtag gtttaatggc tctgattcca caagcagcag atgcactgag 2398441 cgtacctgtc atagctgctg ggggaatgat agaccacaga ggagtaaaag cagctttaac 2398501 cctcggagcc caaggcgttc aaatcggttc tgccttttta atttgtcacg agagtaacgc 2398561 acatccagtg cataaacaga aaatactaga agcaaacgaa gcagatacaa agcttacgac 2398621 attattttca ggtaaagagg ccagaggaat cgtaaataaa tggatggaag aaaatgaaca 2398681 gtttgagaca caaacccttc cgtaccctta tcaaaataca ctaacgaagg caatgagaca 2398741 gaaggcttca cttcaaaata accatgatca gatgtcttta tgggcaggtc aagggatacg 2398801 gtcattgact gaggaaattt cggttaagca gcttttaaat cagctttgcc aagaggatat 2398861 aaaaatatag gcgcacctca ttgatagagc aaaaagcaaa ctttgacagg cagtttgctt 2398921 tttttttcgt aatttcatcc actgactctg gaaatctaaa tactcctaca ttttcaaagc 2398981 taatttgaat cgggttatca atcatcacat tgatacgatg cgatcttgat aatttcacca 2399041 caaccacaat acattaccaa catttcgatc ttatctcccc ttctcaagtt ttgctcccta 2399101 ttcgaataat cgatagctcc catattaaat ttgaatagta aaatggttct ttttcgtttg 2399161 attcagatga tataaagtca tatgataaaa aaagaatgag acagaaagcg tgagaagtga 2399221 tgaaaatagg attttttgat tcaggaattg gtggcatgac tgtattgtat gaggccataa 2399281 aagttcttcc ttatgaagat tacatttttt atgcagatac gttaaacgtt ccatacggtg 2399341 aaaaatcaaa gggtaaagtt aaagaatata ttttcaatgc agctgaattt ctggccagtc 2399401 aaaatatcaa agctcttgtt attgcgtgta atacagctac tagcattgcg atagaggatc 2399461 ttcggagaaa cttcgacttt ccgataatcg gaatcgaacc cgctgtaaag cctgctataa 2399521 ataaatgtac agaggaaaga aaaagagttc tggtagttgc tactaatttg acgcttaaag 2399581 aagagaaatt tcataatcta gttaaagaaa ttgatcacca tgaccttgtt gattgcttag 2399641 ctcttccagg actagttgaa tttgctgaga actttgattt tagtgaagac aaaatcatta 2399701 aatatctaaa gaacgaacta tcttcttttg atctgaaaca atatggaacg attgtgttag 2399761 gatgcactca ttttccgttt ttcaaaaaca gttttgaaaa actgtttggg ataaaagttg 2399821 atatgatttc aggcagtgtc ggtactgcaa aacagttgaa aaaagttctt gcagatcgta 2399881 accagcttgg taaaggatcg ggctcaatca cctttttcaa ttctggccat aaaattgtgg 2399941 accaagaagt catatcaaag tacaaaagat tgtttgaaat attagatgaa actcaaagga 2400001 gtcatgttgg acattgaatg taaatgaaaa agacaatctc ctgaagagaa acatgaacta 2400061 agaagcgggc ttaaaaagcc cacttttttt ctaacaaaca attgagttat acacacatat 2400121 ctgattacag tgttttctct ctttcccctc ttatttctcc cccctctcta tagcttttct 2400181 atttcaataa aacacaagtc tcgattgaaa agttatcgta acatttacac ttcacaggag 2400241 atttttcacg attgcgaatc gaccgtttgc cagatgcaca aagtcataat gtgtaaattc 2400301 tgtatctatg tgcatgttta ttatggaatt attttcataa tgttttataa tacaagatga 2400361 tagcgttttc taattataat gataggggga aataatgatg atgaaaaaag gtctgcttgc 2400421 gggtgcgctt acggcaaccg tgctttttgg cacatgtgca gtagatgtac cgggtattat 2400481 tagtccaaaa accgcagaag ctgcatcaca gctaactgat ggaatcggcg ggagggctta 2400541 cttgaacagt aatggtgcca ttcttgttac gaaaatccag cttcctagct ccactcaggt 2400601 ttcaaatggg acagcctaca tctactctgg ttttagcgga ggcacagaat ccgatatcgg 2400661 gtttcagtac agtgataaat ataatgtatg gaaaccatat atgaaagtcg gttcaaaagg 2400721 acaggatcag gttcagtacc tcgaaggagg aagccaattc acgaatacga aaggcttccg 2400781 tcccggcagc accgtacaac ttaccatcta caaaaacctt aacggcaata cccgcgctac 2400841 atactggggc acgaacaatg ccggatacaa cggccgtctc atttcagaaa tcagcaaaac 2400901 aaatgtcggc tccatctcaa aatggaaagc gctcgctaca gttgcaacaa cagggtcacg 2400961 ccaatctatc aaatcaaact tttcaacatc ttttacaaac atcaccatcg acaacaaagc 2401021 aataacacct gtaattgata cacaagactt cgctaaagta acagtctcag gcaacagtgt 2401081 cagtttatcc gttgtcaaaa attaaaacat gttaaacata caatgcgtta ggctattgag 2401141 aagctctcga tagtcttaaa gggggcttaa catgcccctt ttttcatttc aatttaactt 2401201 tcagttagct tcggtacatg ccgtctatcc ccgtctttta tctgggtgaa gtaagggcag 2401261 ctcgcccctt ctgaacctgt tccatttgct caacgcaaaa ggtgtgcatc actgtcttaa 2401321 aaatgttaaa acaaatagca gatggtgcac tttattttta gatgaggcat gcttacgctc 2401381 gatatgcaag tcaaatgatt aagggtctgc aagagagaga agttttgggt gtactttcat 2401441 aaaagaggga tggcttcata tagctcgatt gcatcaggaa gattagccaa cgattggccg 2401501 agaacaacac atcactttga aacggattca ttccaaaatc ataagtatga tccaataact 2401561 aataaagatc agttagcagt ccagccttaa aaatattttt acatcaatta aactagcatc 2401621 actatcgaat aagctcgatc tgcatatcat gtactatcct cttttaagga aggtgatgtt 2401681 atgaggtcat ttccattaat cgtagttcta ttcatcctat taatcatcgt tgggacatct 2401741 ttctttggtg gctattaaga acacacctta cctcatatcc atcagacgcc ataagaaatc 2401801 tttatggcgt ctgtttttta ttagatttaa acaaaaccat taaagtgggc catgcaaaca 2401861 cacctatgga gattactgcc acgacttctt tgtgagggaa ttattcttcc ctttatggac 2401921 tattgtcgat caaaagagaa agttgaaatg catttttatg gtgagatgaa tcgaggctta 2401981 gacatataaa aaaccgcaaa gctttcttga agaagctttg cggtttttgg gtctcttctt 2402041 tgcttcatat aagccaatag atttcaagcg taatccactg ccatacatcc aatgattttt 2402101 tattttgaaa taggtttctt ctactcttca tgtgagatga ctcaaggtat gccacgtcac 2402161 aataatatgg cggatactga atggtctcaa tcagtttttt ccccattcta tcaattctcc 2402221 acagaaaaaa tggctatggc agaacaactt tcatagagta atcatcattt aatgagccat 2402281 catctcatgg gcaatatcgt gtccatccat ttttgacggg tagtaagtag gccagttttt 2402341 gacttcatca agtaaagctt cacggtcgtc cccccaatag agatggtaat gactagcttt 2402401 agtcgggtaa atactatgat cactaaactg aatatactga ggcagccctt ctgctttttt 2402461 agctagtttg aatatgtatc ttacccctct attgcccgca tcataggtta gaatttcgta 2402521 tccgtcatac gtatacttac cagaatattc ttttccattt ttgaagaacg ttacagtatc 2402581 tttctggatt acaatacggt caacatctgt ttgatagcct tttttataat actctttata 2402641 ttcttcagct gtcttgccgc cttcgtgttc tgatttatat gaaaacactt cgtcaagagt 2402701 accatcttgc aggtatggat atacagattg ccaatctcct tcccaatcag aaagtaagcg 2402761 atcctttact tggctgtttt taaaatagcc ttcatatatt ttttctgttt cttcatcatg 2402821 cgcatgacta tgatcgtgag aatgttcgtg tgtatgactg tcagatgttt gctcttgcgt 2402881 tttggaagag tcttcttcaa ctgctgagga tgatgttgtt tgattagact cacctgcaga 2402941 agaaccggaa gtctgacatc ctgccaaaac tagtaatgaa ccaatcgtta atatgcctag 2403001 ccgttttgaa aataaaatgt tcattccaac actccttttt tattaaatcg aaaacattac 2403061 gatttattat acatacatct cttgcaaaca tcaaaggaaa aatgctcttc atgcggatgg 2403121 cctattttaa aggaataact gactatgttc atcagttatt cctttaaaat acgaaagtct 2403181 acgatatttc catatcgatc cgcttcaatg tgacagcacc cctcaagcag ctgttttaat 2403241 tttccacgtc cgcgttgtac ccttgatttt gctccggagt aagaaatgcc gagcttttca 2403301 ctcaactctt tttgtgataa cccctggaaa tcagttaact cgagcgcctc tcgatacttt 2403361 tcaggcaacc gtttgatggt cgatcgaata cacacagttg cttccttggt gaaattttct 2403421 tcctctgcac tgtcattaaa atgtagaaca tcaggcaata tttcgcttgt tttttttgta 2403481 cggtaaaaat caataatcgt atttctagtg atccgataaa tccagctgtc gatcttttgt 2403541 tcatcgatca gatttgggag atgcacttgt attttcataa atacgatttg caagaggtca 2403601 tcaacgatag attgatcgtt aaccctatgt gaaatatatg tttttaacgg ctgatgaaat 2403661 tgatcccata gatcctctat attcatttga aaaaacctcc tataattttg cgtctgcttt 2403721 acatttgctt cgtcttttta atcgtaacaa agagcaaaca attgttgaat caattgtatt 2403781 gcagctgttg ccaaaaataa tgataaagga gaggtttgtt gtggagtata cctatttagg 2403841 gagaacagga ttgcgggtga gccgtttatg tttaggcacg atgaattttg gagttgatac 2403901 agacgaaaag actgcgttcc gtatcatgga tgaagcactt gataacggca ttcaattttt 2403961 tgatactgcc aatatttacg gctggggcaa aaacgcagga ttgacagaga gcatcattgg 2404021 aaaatggttt gcacaaggag gacagcgccg cgagaaagtt gttctggcga caaaagtata 2404081 tgaaccgatt tctgatccga atgacggacc aaatgatatg aggggcttgt ctctatacaa 2404141 aatcagacgt catctggaag gatcactgaa gcggcttcag acagatcata tcgaattgta 2404201 ccaaatgcat catatcgata ggcggacacc gtgggatgag atatgggaag cttttgagac 2404261 tcaggttcgc tccggcaaag tagactatat tggatccagt aattttgcag gctggcattt 2404321 agttaaagcg caagctgaag ctgaaaaacg gcgattcatg ggactcgtca ctgaacagca 2404381 taagtatagt ttattagaac gaacagctga aatggaagtg ctgccggctg cacgggatct 2404441 tggtttagga gtagtggcgt ggagtcccct tgcaggaggg cttcttggcg ggaaggcatt 2404501 gaaaagcaat gccggaactc gtacagcaaa aagagcagat ttaattgaaa aacatcgttt 2404561 gcaactcgag aaattttcag atttatgcaa agaactagga gaaaaagaag caaatgtggc 2404621 tttggcatgg gtgctggcaa atccagtttt aactgcgccg atcatcggac cacgaacggt 2404681 tgagcagctg cgtgatacga taaaagccgt tgaaatcagt ctggataagg agattctccg 2404741 catgttaaat gatatctttc ccggacctgg aggagagaca cctgaggcat acgcctggtg 2404801 atacattcat tactcaatac tgacattttt cttaaatatt tatactgaac tatcatatta 2404861 agaaagacaa gagcatgttt gtctcttgtc ttttccacat cgtgctgaaa atgctggcta 2404921 aacatcgaca aaaatgctgc cgcttaaaaa agaaccctaa acaatagagt aactggaaag 2404981 acaactggct tgatcagctt gggacccctt tcagctgtat ttaaatcaat caaactaatg 2405041 attcattggc agtctaaata ttattattgt ttctttacaa aatagtaata gcccctgtaa 2405101 tgattgctaa caacgtaata actaatgatg taattacagc ccacttaacg gcaaaccttt 2405161 gaaatgaccc caagtccatt ttaagcatgc ttactagcaa tactgttgac gcaaccaatg 2405221 gactcatcag atgaaccggc tgccccatta tagaagccct tgcaatttct actggttcta 2405281 taccatatgc tgaggcagct tctgcaaaga taggtaccat accaaagtaa tatgcatcat 2405341 ttgataaaac aaaagtaaac ggaatactag tgagtgctac aataacgggg aaaaaccctc 2405401 ccattgatga ggggatgatg gatattaatg atcctgctat ggcatccacc atctttgtcc 2405461 cggataatat accagcaaat actcctgctg aaaataccaa taataccacg gttatggcat 2405521 taccagaatg ctcggcgatt cgctccttct gcatttttac attcggataa tttatagtaa 2405581 gggcaagaac aaaaccaatt aaaaataaaa ctgacggatg cttagttcca agcacaataa 2405641 acaccatgat acttataacg aggaataaat taagatatat taagcgtggc cttttcaatt 2405701 gttcgctctc caaagtagca gccatataag attgagagct gtcctttgtt atatgtctag 2405761 gctctaattg aacgatgcct attcgattcc tctctttcct tcccattaga aaagccagaa 2405821 atatcacaca agcaatacct ccaagcatgg tcggaagtaa tggcacaaag aaatctgaag 2405881 gatccaaacc cagcactgaa atcgctcttg tagctggtcc gccccatgga gtcattccgc 2405941 taacgatact caacgacagc attgctaatg tcgccataac catgggattc ataccaattc 2406001 ttttatacaa aggtaacatt gctgagactg ttatcatata ggttgttgta ccgtccccat 2406061 ctaaagcgat aagcattgcc aagacggcag accctatcgc tattttcaca gggtctccct 2406121 ttactataga taaaattttt tctattagcg gatcaaataa acctgcatca attaaaattc 2406181 cgaaaaaaag aatagcaaac aatagcaatg ccgctgaact tgcaactgtt tgaattcctt 2406241 ctaaaatcat gtcgccaata cccttaccaa aacctccaat aagagcaaaa acaatgggag 2406301 tgatggtcaa ggcaacaata ggcgagactt tctttgtcat tattaatatt gtaaaaacag 2406361 ttaccatcga aaaacctaaa atagtaagca tattacacct ccaagaatgc gctttcaaat 2406421 gacttttgat taacatatct tatacggtgt aataagttaa ataaatattt ttttactgtg 2406481 tttcaaaaaa aattctatca taactttaaa tggttaccat ttgttcaccc tttaaaaaat 2406541 caatgaatgc tttaacgagt ttgattccta atgatttttg atcgtacatt agccaagtat 2406601 ctctcattag aggcttaccc ttagcattat acagttccat tgtgtacaaa tgatcagatt 2406661 cctgcaggca aatttctggt gctatggagt aaccaagacc atgctttacc atctctttgc 2406721 aagtctcttg tcgatccact tccattgcaa taatgggggc ttgttttaga ttcgtatgca 2406781 tccaatcttc tataatcgtt tttaaagaag catccgtttt atatttgata aaaggtaaaa 2406841 aaggaagttg ctctatcgtt attggttttt ttgagatgat atgtaatttt tcccgtgtca 2406901 gccgttcctc cacccctttc cagcgatggc ttcctctcag tataccgact tgtacaatac 2406961 cagcatctaa taatttcatg acatctgtgc tccagcctgt ttgtacacta tattggacat 2407021 taggatacat agtggaaaat tcccttaata acttagggag cttatattga gcgaaattgc 2407081 ttgatacccc cagccttaga tgtccttgca cctctttgct tagattagag atatgatctt 2407141 tggtatcttg aagttcctgt agcattcttc ttgcataagc aaccaagtgt tctccttccg 2407201 cagtaaaggt aattccttta tgccttttgg tgaataattc aattccgaaa atctcctcaa 2407261 tctttttcaa ccgataagtg atggaaggct gtgatgtaaa taatcgttct gctgtttttg 2407321 ttacactttg ttcttcgtga agaattttca ataaaatcca atctttctca tccattttca 2407381 tcttcctttc tagtccttct ttcacaatta taaaagtttt tttatcgaat attaagaaaa 2407441 cttatatttt atttttattt ttttaccttc tacactaaaa aacataaaaa atactacctt 2407501 taagatgagg atgatgacga tggtcaagac gaatgtaaca atcatgagag gcggaacaag 2407561 caaaggcgtt tttttccacg aatcagccat gcctaacaat aaaaacgaat gggagccctt 2407621 tttgcttgat gtcatgggaa gtcctgataa aagacaaata gatggtttgg gtggcggtaa 2407681 ttcccttact agtaaagtgg caataataaa gaaagcatat acttcggata ttgatgttca 2407741 ctatactttc ggtcaagtca gcatttcgga agaaaaggtg gactttaagg ggaactgcgg 2407801 aaatatctcc gctgctgttg gtccatttgc tattgaagaa ggacttgtaa aagcgaaaga 2407861 accaatgact gcggtaagga tcctgaatac caatacgaat aaaatgatca ttgcggaagt 2407921 agaagtggaa gacggtcagg tcaaatatga cggagatgtt acgatatctg gagtacctgg 2407981 atctggatct ccaatctatt taaactttca tgatgccgct ggttcagtta ccggtcattt 2408041 attgcctact ggaaatagtt cggagttttt agatacaagt caaggccaaa tagaggtgtc 2408101 tattatcgac tatgcaaatc cattagtttt tgtggaagcg agcagtatcg gcctggatgg 2408161 aacggaactt gcagaagaat ttactgatct acagttggct caatttgaag aattaagatc 2408221 cattgcggca gagaaatgcg gctttgccag tcgattttca gctacaaagt tatcgccggc 2408281 tgtccccaaa ctggctatag tagcaaaacc agagaaatat aaagatagta caggtgcttg 2408341 gcattcaagc gttgagatgg acttacacat caggatgatg tccatgcaaa agccacatca 2408401 agcactggct gtcactggag cgatatgtac aacaagagcc ctttcagtgg aaggtgcaat 2408461 ccctgcaaga atagcaaaaa accactctac aaaggttcgg ctagctcatt cttctggtat 2408521 tattgaaaca atggtggagc ccactggtat aaagatcgtc cgtaccgcac gacgtattat 2408581 ggacggaaca gtttatacgc atggagacta tcaaatgatg tagatggact gtgcaaaaag 2408641 cctcccccct ttccatcgtt aatagatgga ttgaatgcgc cttcttgcac agatccattg 2408701 taatcttgca tggctttaaa aaagcctcta tattgttttt tatgaaatcg ccaaggtcct 2408761 ttcatgtatc tgcctcaagc atgacataat cattatagag aaaattgaat actttttact 2408821 gcaaataaaa agataccaac atcattggta tcttttagat tgagttcatc tgcagcggtt 2408881 tcttttcctc actgcttatt tgattacaaa attaccgtac tcgtttgaac gaacatgaat 2408941 cggtccgttt agattatagt tgttctcctt ggcgatagag cgaagcacgt ccacacgggc 2409001 aactgattct ctccattcgt cacgggtgtc atgattggcc ggattcatca gatcgtcata 2409061 gcgtacgtcc aagaatttat tcaaccactt cttctcgtct attccgtctt taggtgatcc 2409121 gcccgctttt ttgttcgtac gtttaatcaa ggcataaaaa gagtcagggt catcaccatc 2409181 gccatgctga ataaccgtat cgtacatcac agctcttgcc aatgctgttt ttagtccggc 2409241 attatccgat cgtttcatgg caggctgata atacaaatgg tcatttactt tgtcttgagc 2409301 ggcgcgaaat tccttatcat ttgcaagcga cttccaggca gaagcgaatc ccttgagatt 2409361 gcttgtatca tcgctttctt ccttggccag acggcgcaat tcaggcagat actttttcag 2409421 tttgttattc ggaactgcct ttgtgtatac ttccactact tccaatgcat ccccggtagc 2409481 cgttgtaaag cctgcccgtc cgcatgtata gcctcgcccg tcatccaatc gctctacata 2409541 tccatattgg atctccgttg tgccgttttc aaagatactt gtcagctgtt ccgcccggcg 2409601 cttttgatct ttattcagtc ccgccgcaaa aaccgtttcg ctcatcatca gggtaaaaaa 2409661 catggtgaaa acaagtaatg agatcgctgc ttttttccaa aaatctgctt tttgcatact 2409721 gattttcatt tcacttcccc tttctaaata ttgtaaatac agactcagta tacatgaaga 2409781 aactgcccta ttgttgaaaa tacatcaatt tgtcaatatt ttgaatctaa agtaatatag 2409841 cttgaatctt actctattca ttgccaatca gccttagccc ctctcactgg gaaggtccct 2409901 tgattttcat actgcttcaa ctttcattaa caagatgcca taaggcttta ctctatttta 2409961 taatggaagt gatcatcgaa aatcgttagg gaggtgatgt aatggcaagc aagatgagaa 2410021 tgccagattc cgcaacgtcc catgcaaagc ctactattgg gaaggcgata ctttgcatgg 2410081 ggtagacttt ctaaaagatc gcccaagtaa gcttttctga tatagtggct ttgcacctta 2410141 tttgacataa aaaaataagg agctggcaga aatggcatat gtaaaagcaa ccgctatttt 2410201 acctgaaaag ctgatatcgg aaattcaaaa gtatgttcaa ggaaaaacaa tatatatccc 2410261 taaacctgaa tcctctcatc aaaaatgggg tgcgtgttca ggaacaagaa agctgatcga 2410321 tgacagaaac gcttctatta aaaaagcatt taaaaacggc aaaaccattc atcaattatc 2410381 tgatgaatat cacctctcta ttgaaacaat aaaaaaaatt gtctactcta aataaacaaa 2410441 acggaagcac tgataaaaaa taatcagtgc tttttatatg gcgagtttgt ttcttagtta 2410501 tttcctgcat atgataccat tggccaattg tgtaaagtta agggagatga gaagaaagga 2410561 aggtcctaca aatgacgata aacaatggaa cgttgcaagt acccggcgcg aacatccact 2410621 atcaggtgcg tggctctggt ccaatcattc ttttggtcca cggaggaggc ggtgatgccg 2410681 acaagttcca tcatgttgcc aatcatctgg ctaactggta cacggttgtt acttatgatc 2410741 gccgcggcca ttcccgcagc aatctcgcca atcagattga gggttaccgt gtggaaacac 2410801 acagtgacga tgctcaccgt cttctagcca aaatcaccaa taagccggcc tatgtatttg 2410861 gaagcagctc cggggctgtt atcgggcttg atctgtgcat acgccatccc gaacaagtac 2410921 atgtcatgat cccacacgaa ccaatcttat tgcagcttct gcatggaaat gagctgaaac 2410981 aagccgagca attcatggaa gaccttaaga aaaatcatcg aagtgaagtc attaaattaa 2411041 tgtcaagatt agagacagac gaacaatcaa aggctgtcct gacaaagcgg cttctcggca 2411101 attcaacgta tttcactgag tatgaaattc aaggaattct cagctataca ttagatttcg 2411161 aagcattaaa aactgtgttt acatcttcac cgatgaagat actcccagct ggcggaagtg 2411221 cttctcggga gctttttcct tatcgttgcg cgaacgccct agcggaacaa ttggaaacag 2411281 aatgggttga attccccgga aatcatacgg ggtacacaat gtaccataaa gaattttctg 2411341 agaggttaca cgacatgtta gaaaaagaaa agaaacatac gtgttaagga ttgattaaaa 2411401 ttttcaaaat aggacaggtg aaactaacta tggaattgga gaagatttca cgaagcgtaa 2411461 aaagaacttt tcactaacga gaacgcaatg tgagatgttt aaccaaagtg atattaggga 2411521 tttcatcgaa aaataggttt gtacattacg ttctcctatt gattatttcc tatcttaatt 2411581 ccgtatttta taccattaga tacaactcta aagcggctcg ttattttgtc ctcaacaaca 2411641 accagtgtct aacatcatga atctcttttg aaaatcacca caaatgcagg tatggaagac 2411701 ttcatcgcag caaaaaccat accaactatt gttgttggta tggttcgtcc tagataggcc 2411761 cttaagaaga gattctattg tacggagtat ttagctaatt gcatttgtaa ccgacagggc 2411821 cgtctgaacc tgtgtacaca tatgtgtcag acacatatcc aatattcacg acaccccggg 2411881 aatctttcca ctggatttgg tcccagatat tactcgttcc atacttccct gtaacagtcg 2411941 ttccataagc gtaacaataa taaggaacac gggagccact cggaatggaa agcataatag 2412001 gataatttgt accaggaccg ctgcgcatat tgacaggcgc accgctgctt gttgagacag 2412061 taaagtactg aacggcaagt gcctgactgg aaaaaatgaa taaagatgca atcatcacgg 2412121 ttaacatact cagcattttc agtttagtca atgtcatccc tctttcttca attccttcat 2412181 tttaagaaac gatagaacat aggctaccag ctgcatttag gaacaaccgg accgtctgag 2412241 cctgtataca tatatgtatc agagacaaat ccaggaacga tctccccgct ggcaagcgtc 2412301 cgctctgtgt aattccaaat attgctcgtt ccatactttc cagttacagt tgtaccggtt 2412361 ttgtagcaat agatcgggat gcgggttccg ctcggaatgg tcgttacaat tccccaactt 2412421 gtacctgggc cgctgcgcat gttgacagga gcaccgctgc ttgttgaaac cgtataatac 2412481 tgagccgcaa gtgcatggct agaaaaaatg aacacagatg caatcatcac cgttagcata 2412541 cttagcctct ttaacttatt caccttatac cctcccctta taaatgccgt acgtttgact 2412601 ttcttacatc cagttaagga tttactttca gataccatgc cccctcccct cccatatatt 2412661 tatcaatgta ccataaacta gatctttcaa aagtggaatt attcctatgt tttcgacaat 2412721 taaggataca aaataaatgg tagtcaggct tgatattgat ggtgtgttac atttggctct 2412781 taatcatttg tccagtcggt aatcacgatt gacaatcagg aaaaaggaca tggatcaagc 2412841 ggcttcgttt ccaccaatta actcaatcag tgtactgctt ccttgtatcc acgcttcttc 2412901 tcgattcata gatactccac ctttttcacc aatcaaaaac ggacaccata caaatcagcg 2412961 taaatgctgc aagttcagtg tccgcaacct attatgactt tgctttcttt taccagggcg 2413021 tgtaaaaatg attaggtacg ttatcaaacg ttattctatg attttgcgag tcaaaaaatc 2413081 ataacatttt atatatttca atcagattat gatctggatc tctgaagtga gcaactcggg 2413141 cactccattc cttgcgatca tgcggtttat tctcacattt aactcctttt tcgtgtaaat 2413201 cgtcatacgt tttatcaaca tcttctacct taaactgaag caaaaatttt gattgagctt 2413261 ctccttccaa ggactttttt tcctctccaa cgatttcagc catcgtttct cgagataaaa 2413321 gctctatttt cgtttcccca ttatcaaaga gtgcatattc catttcattc tctaaccaac 2413381 ttattggaag tcctaatgaa tctttataaa actcgacgct tttcttaaaa tcattcacca 2413441 acagtctaat ttgtaacagc ttcatatcga gtgcctccta taaaaccata cttttactgg 2413501 tcatccaatt taatgatacc aaagaaacct gacagcacta tgtcaagttt ccatacttca 2413561 cccttatttc agatttaagt gcagtttagt ccatgtcata agaacgagca aaaacagcga 2413621 ttcttaaaac aaaaaatgat accgagtgta ttttctgtat gcttcaactt catttcggga 2413681 aatgtaacgt tgataaaagg aggttacatc aatatggatc atcaaacatt ggcagctcat 2413741 gaggctgttg acttacatga aatcgtgaac tttaaaacac tttgtatagc gaaatcaaag 2413801 ttaatgcaag ggcttgtgtt tgaccaagaa ctgaaggact tgatggaaaa agatgtacag 2413861 caatccattc aagaccttac tgaattacaa gcggtttatg agcgtgcctc atttcaggcc 2413921 cctgtccctc aaagccgccc aacgccaatc atcaattgaa agggaggtaa gcctctttga 2413981 ataatgatca tttagacccc attaattcgc tgaatgtgcc tgaactagca gacactacat 2414041 tcgcgatgga ttttcttata cgagctaagg aaggcgtaag gaatactgct gtagctttga 2414101 cagaaaccgc ttcaccagat gtaagagcac tgcttcggaa acagctgatg caaggaattg 2414161 cgatgcacca agagattacg gaactgatga tcagcaaaaa gtggttccat ccatatgagc 2414221 tgagcgaaca gtataagctg gatcagctct ctgcaaaaaa cacgatcatg gtcggcaata 2414281 tgaacctctt tcctgatgaa acaaatcgca aagggatgtt tgaccggaca cctgatgaac 2414341 actaacactg gaggttttac agcatgaagg cagtaacgta tcaaggcatt aaaaatgttg 2414401 ttgtcaaaga tgtccccgat ccaaagattg aaaaatccga tgacatgatt atcaaagtca 2414461 ccagtacagc catttgcgga tcagatttac atttaatcca tggattcatt ccgaatatgc 2414521 aagaagacta tgtcatcggc catgaaccga tgggaatcgt cgaagaagtt ggttctgggg 2414581 tgactaaact aaaaaaggga gatcgggtaa ttattccctt taatatagca tgcggggaat 2414641 gctttttttg taaaaaccag ctggaaagcc aatgtgatca gtctaatgac aatggggaaa 2414701 tgggtgctta tttcggctat tcagggcaaa ctggcggtta tccaggcggg caagctgaat 2414761 atttaagagt gccgtttgcg aattttaccc attttaaaat ccctgaatct tgtgaggaac 2414821 ccgatgagaa attaagcgtg attgccgatg ccatgaccac cggcttttgg agtgtggata 2414881 atgccggcgt aaaaaaaggc gatacagtta tcgttctcgg ctgcggacca gtcggcctgt 2414941 ttgctcaaaa gttttgttgg ctaaaaggcg caaaacgcgt catagcagtt gactatgtaa 2415001 actatcgctt acagcatgcg aaacgtacaa acaaagtaga aatcgttaat tttgaagacc 2415061 atgagaatac agggaattat ttaaaggaaa tcacgaaagg cggagcggat gtagtcattg 2415121 acgctgttgg gatggatggt aaaatgagcg atctcgagtt ccttgccagc ggcttaaagc 2415181 ttcatggcgg aacgatgagt gcattggtca ttgcttccca agctgttcgc aaaggaggaa 2415241 ccatacaaat tacaggtgtg tatggaggca gatataacgg ttttccgtta ggagatatta 2415301 tgcagcgaaa cgtcaatata cgctctggac aggctccagt gatccactat atgccgtaca 2415361 tgtttgaact agtatcgaca ggcaaaattg atccgggaga tgttgtcagc catgtcctgc 2415421 cgcttagtga agccaagcat ggctatgaca tttttgattc aaaaatggat gattgtatca 2415481 aagttgtgtt aaagccttaa aaaacggagg ttacagaaat ggaatacgcc ttacacgaag 2415541 tgcttgaggt tcaggaaatg actgcattta agacactttg tttgacgaaa tctaaaacaa 2415601 tgaaagcact ggtatctgat ccgaagctga aagaaatcat gcagcaagat gttgatatca 2415661 ccacacgcca gttgcaggaa tttgcctcta ttttatctaa tgcaaagcaa gaatgaggag 2415721 atgaataaat catgaatcct atcatagaat atctgactgg catgaatgtt ctaacagacc 2415781 aaatcattgc tatggactta ttaatttcag caaagaacgg agtcagaaat tatgcgatgg 2415841 cagccactga agccggaacg cctgaagtaa aagaggtcct tatccgccat ttggaagaag 2415901 cactcgatat gcacgaacaa ctctcaagct atatgatgga aaaaggctgg taccatcctt 2415961 ggaaccctga cgaacaagtc aagctgaatt taaaaaatat tgatacagcc attcaattgc 2416021 caacccttta acatacaatg actgatttgc tgaggaacag tattgattgg ccacaactgt 2416081 tcctcagctt caaaatgagc actgtttgtt cgggtcctat gaccgtaaat agattaaccg 2416141 cttttctcca tctgatctcc gataatgttt gcaaattctc caatccaaat aaggaatcgt 2416201 aaccacctct ttttatgcga tctcttgatg gagaaaacag gccagaaaca aaatccttcg 2416261 tttttgacct gccctcttca cacgcaaaga atgctacctt ctttgctcca ctgatccgtg 2416321 aagactttcc gttttaggcc tgcttttgag ctttgcctca ttttcacgca atttcccatc 2416381 ataatcttta atttttgtgt ctaatctctt aattgtttca tcaatttctt tccgcttctc 2416441 tatcagccgc tgtcgttcgt cagccaggat attttttcga gcttctaccg tacggtcacc 2416501 ttcggtaaat aatgttgtat attcaattag cgcttctatc gatagtcccg catttcgcat 2416561 gcatttaatg aattcaatcc atttgatatc ttcttcatca tagtcgcgaa tgccgctgtc 2416621 ttttcgtttt acaggcggga ttaatcctac acgttcgtaa tatcggagtg ttgcggctgt 2416681 caggccaaac tgctttgcca cctgagcaat attcatgatc ttcacctctc tatcctgtat 2416741 gttgtgaagg taacacttaa agttaacttt aagtcaagct caaaacaagt ggttagctgc 2416801 tgaatctggg tttatatatt cgggacttgc cttaaagcac actttaaact ctatacttct 2416861 ccatgcacta aaaacagtgt agttggaggg attgctgaat ggcaaataaa cacactgccg 2416921 gaagagaaca attaggagaa tttgcgccaa agtttgctga acttcatgat gatgttctat 2416981 tcggtgacat ttgggcaaga gaagaagaac tttcatcccg ggatcgcagc atgattacag 2417041 tttctgcatt aattactgac tgtttctcag cttataaatc aggttcattt taaatggttt 2417101 ttttaaaaaa cccttgcctt aaagcagact ttaaggttta tcgttatgtt gaagacacca 2417161 taaaacataa ataagtgcat gtttttattt acaacactta tgatgaagaa aggataggtt 2417221 cgtatgtgta atcaacatca aacccgtgta ttaagcgtgt cacatgcaaa agccaaattt 2417281 gaacaaacga cgattgagcg aagaggatta cggccgcacg atgtcttaat cgatattaaa 2417341 ttcagcggca tttgccattc agacattcat agcgcttttg atgaatgggg cggtggcatc 2417401 ttcccaatgg tgcctggaca tgaaatagcc ggtgttgtaa cagccgttgg aacaaaagtc 2417461 accaagttgg ctgtcgggga ccgcgttggt gtcggctgtt ttgttgactc ttgcggagaa 2417521 tgcgaatact gtctcaacgc agaggaacaa ttctgcacga agggtgttgt tcaaacgtat 2417581 aactcagtag actacgacgg aaaccccact tatggcgggt acagccaaaa aatcgttgtc 2417641 actgacagat ttgttgttcg cataccagat cgtttggaaa tggatgttgc cagtccgctg 2417701 ttgtgtgcag gtatcacaac gtattccccg ctgaaacact ggaatgttgg ccctggtaaa 2417761 aaggttgcga ttgtaggcgt aggtggcctt ggacatttgg caattcaatt tgcacatgcg 2417821 atgggtgcag aagtaaccgt cctgagccgt tccatgaata agaaagagga agctctggaa 2417881 ctcggtgcaa atcattactt tgcaacaagt gacccagcca cattcactgc attggccggg 2417941 cgttttgacg tgatcttaaa tacggtatcg gcaaatctcg atgtagatgc ctatttatca 2418001 atgcttcgta tagacgggac acttgtaagc gttggagctc ctgccaagcc ggacacatac 2418061 agtgtgtttt ccctaatcat ggggcgccgc agcattgcag gttctctagt cggcggaatt 2418121 caagaaactc aagagatgct ggatttcgca gctgagcatg gcatcgaacc taaaatcgaa 2418181 gtcatcggag ctgaccaagt ggacgaggca tacgaacgta tcctccgaag cgatgtccgt 2418241 tatcgatttg tgattgatat ttccacattg taataggtta gtccttatat gggctgccgc 2418301 ttttattgaa actcacgaaa aatgatctct ttaagcaaat attttgaagg ccggtcaatc 2418361 ttcctgttat tctatgaata gagagttatt aggagggttt tttatgagca aaaaaattgc 2418421 agttcttgtt acagaccaat tcgaagacat cgaatataca agtccggtaa aagcatacga 2418481 agaagctggc tacagtgttg tggctatcga tttggaagcc ggcaaagaag ttaccggtaa 2418541 gcatggcgag aaagtaaaga ttgacaaagc catctctgat gtggatgcaa gtgactttga 2418601 tgcactttta attcctgggg gattctctcc ggatttgctt cgtgcagatg accgtccggg 2418661 tgaattcgca aaagcatttg tcgaaaacaa aaaacctgtt ttcgcaattt gccacggccc 2418721 gcaagtactg attgatacgg atcttctaaa aggcaaagat atcacaggct accgcagcat 2418781 ccgcaaagat ttaatcaatg ccggtgcaaa ctacaaagat gcagaagtag tcgtcagcca 2418841 caacattgtc acaagcagaa cacctgatga tttggaagca tttaaccgcg aatctttaaa 2418901 cttgttaaaa taacaagaag gcacagactg ttcgggtctg tgcctttttt aaaattaaga 2418961 ctccttcgtt acattctgaa agacagcagt cgcgtcccac acattcaagc caaattggcc 2419021 ttctgaaaat acggaatcat gtgcatcaat cacaagacga tcatctaaat agattttaaa 2419081 gcgatcgccc tcggcctctg ttttcagatg atacttttta ttaacgtcta tcggtgtttt 2419141 gtattcagca atgacagaag cagcaccgtt ctcaaattta aagaatttca ctaggtcatg 2419201 cttcgcatcc acattggcaa ggtaaccgtt tttggcatct ttgtcagagc gaaacattag 2419261 tgctcctgcc cctcttccgt ttccatcctt aatggtgata tcagattcat aagtgaagtc 2419321 tgacccggat gctgaagaca agataaagga atcgccgtcc gacctccctt gtttcccctc 2419381 aattgtgtct gcccacgtgc catttacagt cgtccagcca gtcatattgg acataaaagg 2419441 tgtcgttccc catacctttt ttaaagggtg tatcgttaaa gattttacct ttacaccgcc 2419501 atttgcagca tataattcaa gccctttgct tgatcggtct gggagaataa tatccgttat 2419561 gacctgcttt ccgtcattcc caaatacttc aaccgaggag cggtcaacaa aaatgcgcaa 2419621 cttaaccttc ccatttaccg gcttcaacgg ggctgtttct tttccggtgt taaaggccgg 2419681 attaaaggtg tcgttgcctg actcgctccg gtcaacgaac aatttggcgt tccttcggtc 2419741 atagccgacc ttcgtaaatt gattttcacc tgttcggacc ttaaaaccaa attcagcagc 2419801 tgaaccaggg cttactttaa attctgcatt tatttcatag gcatctccag attgccccgc 2419861 taacacatta tgacttgcag gcgatatggt cagattcttc cacttcttag aggttccgcg 2419921 aatggtttcc agctctttca ccggtgtttg gaccactcta accccttcgg taaacgcttt 2419981 caattttaac tctcttggaa tggacgttgc acttctccat ggggatgtcg gaacatcatt 2420041 cgcatattgc caattgctca tccaccctaa ccatagccgg cggctgtctg tggatggaat 2420101 atcagaccag gatacagccg cataaaagtc tctgccgtaa tccgtccaga gaactttgtt 2420161 tggcgggttt tcatttttaa aatgagttcc atcaaagtcc cctacaaaat attgcatgcc 2420221 tgatcctccc gagaccgctc cgtttccgac actgacctgc atgacccatt tcttttgatt 2420281 cggattgccg tctaccggaa gctcaaataa atccgggcat tcccatactc ccccgtggct 2420341 tccttgatcc tgtccaaatt cacttgcata cgtccactgc ttcagatttt ttgatgtata 2420401 aatgaggatt cggtcaccgg ccgcaagcac catcacccac tttttttctt tctcatacca 2420461 aaagactttt ggatcgcgaa aatctttttt acccgggttt ggaatgacag ggttgccagc 2420521 gtacttcgtc catgttcttc ctttgtcgtt gctataggca atactttgca cttgatggcc 2420581 ttcccgatcc tgtgtataaa tggccacaag cggcttctct ttgcctgttt gaaaaccgct 2420641 tgtgttattt ttatctacaa ctgcgcttcc agaaaagatc gtgccttttt catccggata 2420701 cagcgcaaca ggaaggtgtt cccatgtaac caaatctttg ctgacggcat gcccccaatg 2420761 catgggcccc cactgaagcc cgtatggatg gtattgatag aacaagtgat attccccagc 2420821 ataatatacc attccgtttg ggtcattcat ccagtttgcc tccggtgtga agtgatattg 2420881 aggacggtaa tcctcatcat agtagcttga atcggctgca tctgccgaaa atgccatagt 2420941 caacagcagg gtgaacatga tcatgacttg aatcagtctc tttttcattt gttccttcgc 2421001 tcctctcttc atgtttgaac actttcaaaa gagactgctg cgcaagctgg tccgtttctg 2421061 gcaattctcc tctgtttcac tgttatccga atgatttata tatgaaaaga ctgctgcagt 2421121 ttctctctct ttccttcaca caccttatgc taagaatcca gcccaatacc cgagaatccc 2421181 gatgacaaag atgccgcaaa taatgagaag tggattcacc cctttgcgaa gcatccatgc 2421241 caccaataac gttaatccga gaggcagcgc ccccggcata atgctatcta gcacgttttg 2421301 taccgtttga acatctactt ttccgctttc atccttaatc ctggatacaa cgattggaat 2421361 gttgatggtg gtccatttgg acacgagagc ccccataaca aataacccga gaatcgaagc 2421421 gccctctgta agcttttgaa tgcgattccc cgctaaatcc tgaagaatct ccattccttt 2421481 cacatagcca tactttaatc cgtaatattt tgtgcttaat cttatggcat tcagcaagaa 2421541 aaagaatagc aaaggaccgg caatgtttcc tcctaaagca agggaggctc ctagcgcagc 2421601 taagacagga cgaatcgttc cccaaaaaat tggatcgcct acgcccgcta ttggtcccat 2421661 caaaccgatt ttcattccgc ttatcgcttt tccgtcaatt cctttattgt tcgccatttc 2421721 ttcttccatg gctgccgtca cgccaaatat aggcgctgtc agccacggat gtgtattaaa 2421781 ccattccaaa tgccgctgta aggcttcgtt tcttttcgct ccgggaccgt acaatttttt 2421841 gatcgccggt atcatgacat aacaatatcc cattgcctgc acacgttcga agttaaagga 2421901 accgagtaaa aaatttgaac gaataaacat gctgaaaatt tctttcttcg ttaatcgttt 2421961 ttctttctcc attttttctt ccccctcatc gtttaggcat caagatcatc atcatcgtca 2422021 tcataaacag caacactgcc actgtctgat gcggccgcga ctgctccgtg agcgctttgt 2422081 ttttgcatca cctgctggta taaaagcgcc agacagagac caagggctcc aaatcccact 2422141 aagttaaaat cggtaaacgc cgctaataag aaaccaatat agaaaaatgg ctttaaataa 2422201 ggaatattca tcatattgat caccatggca tacccgacaa ccacaataat gcctccgcct 2422261 atttgcagtc cttttgtaat gacatcagga atatttccca ggaacgcctg aacagcgctg 2422321 acactaatta aagcaacaat caatgtagga atcatgacgc gcaaagcttg aaacaccatc 2422381 gcggtaatat gcataatttc aattcctttt atatttcccg cttttgcata ttgatcagcg 2422441 cggtggatga aaaagacagt gatcgtccga acaaaaatcg tcagcgcctg acccgcagct 2422501 gctaaagcaa cagcgacagc aatcccttcg ccaattcctt gatcagcggt aataactaaa 2422561 atggttgaga tgacagaggc gatcgctgta tcaggtgcca tggcaagccc gacgttcatc 2422621 cagccgagcg ccatcagctc cagtgtgcct ccaagaataa ttcccgtttt taagtccccg 2422681 agcaccaagc caaccaacgt acaggccact agcggccggt gtgtctgccc ttcatccaat 2422741 acacttgcga ttccggtgat tgctgcaatg attaacaaca aaataatttg taatgaagac 2422801 atattctcat ccccttgatt attttgttac gttccgtaaa atctgtacaa aatcctcact 2422861 ggcatctgaa ggcagctgcc tcaattccag tttcacgccc ttgtcactta atgtttcaaa 2422921 tgcctttata tcttgttctg tgacactgac tgattttgtg atttgcctgc gatgattttc 2422981 aaaacgcatt cccccgacgt ttacggtttt gatcggtaca cctgcttcta taagagatac 2423041 aatatcggac ggattttcaa acaagagcat tgccgttacc ccttcgtagc gcggactatg 2423101 aaatgctttt gccattttag aaaccgagac ggcactcgcc tttacatttg aaggcgcaac 2423161 agaaaggatc agcgtttttc tcatttcgtc ctgagcaata tcgtcggaga caacgatgat 2423221 tcggtcggct gcatggactt ttatccacct tgtcaggatt tggccgtgaa taaagcggtc 2423281 atcaattctt gctaacacaa tgttcatcat aattcatcct ctcttgtatc ttgattggct 2423341 gtttttactt tttctaaatg ttcactgcac acttgaaagc tttgctgact cattgctttt 2423401 aagttgttca gcaaatcttt gagagccaga tgttctctca ggcttaatac ctccagcaga 2423461 atcggcaggt ttacgccggc agccatatcc attctttgat cctcagcaat aaaggaagct 2423521 gccgcgttat atggcgtccc tccaaaaata tcgactaaaa aaagcacttc atgttcttcc 2423581 gggatatcct tgagcgcctg atgatatttt tcttgcagcg tttgtattcc ttcccctttg 2423641 aaaaacggca ctgcaatcag gttattttct tcaccgaata tcatccctga agactctttt 2423701 aatgctatgg gaaaatctcc atgaccgctg ataataactg aaatcatatc tattgctcct 2423761 ttcctgtttt gtacatccat atataatgca aggatcgtgc caacacagtt gtgttaagcg 2423821 ttttcattgt tatttcagcc aatagcaatt tgttgttgaa acacttaaaa cgaaaaaaat 2423881 aaacctgtat taaaatggtg ttccatttaa tacaggttca tatgaaaaaa ctgtttttaa 2423941 aacagctggc catgcacttc ttcagcaaat atggcggcta taaataattt ttcatcatca 2424001 cttatgcgaa gtccgagctt ttcttcataa ggggctaatg ttcgctctgt cacgtacacc 2424061 atttccttca gctgatcatt gatctcttct tcctctgaga aagcgatcgg attctgctta 2424121 attacccttt caaaggcgaa agccgtgtgc ataatgactt tgatcaaaac cgcattattg 2424181 aaaatgaccc ccagctcatc ctgaacggtt tgcagccact ccaataacat gtcgatcaca 2424241 tggtggggat tcaagaagac aaggtatttt ttcaggctat cctcgcaaag ctccctgaca 2424301 ataatatttg cttcgttcaa tccattgctc aaggagatgc ttccttttgt aatcgcctgt 2424361 tgaatcagct tctctccctc cccttcaatt aacacttcta aagatacatg cggagcattg 2424421 attttagggt ctttcgttcc gactgtcgca aggatttcat actctttttc gatttctttt 2424481 atgctgttgg ccagcttaat cgatgatacg gtcaatatgt gaatgggggt atcggaggcc 2424541 ttgtttacga tcgtggttag aatgtcttcc agctttttgg ccgttccgct acccgtcgtg 2424601 cagatggata ccaatgcctt ctttttgccg gatgccgctg gctgacgctc ccacaactcg 2424661 ataaaatcct tcgtgaccga ttgatagatc gcatgcaaat ttaaattcaa atagttgacc 2424721 tttctgacag catccagcac cattgaagtc gtaacattgc tgatcgtttt aatagaaatg 2424781 cctgtctttt cctccagcct gctttccagc attgcaagcg accccatatc taccagcatt 2424841 aaaacacctt caccttcatc aacctgtttc attttttctg ctacgcattc aagaatgtcc 2424901 gaaggtgaaa cagtaagcgg catgtcaact gctgcaatcg gcgtactccc tagcagttct 2424961 gtcgcgactt caaccattga actcgccgtg ctgtttccat gagctgccac gataataccg 2425021 actcttttgt tctcctttaa cgatttgatg gaatgaatta acatcgttaa gtagatgact 2425081 tctatttcag gaatagccac tttaaaatat tcctgaattt tatctttaaa aatcatcgcc 2425141 acccgatatt ctttcacatg ggtatcacga atttcatctg tctcctgtgt attcaaaaca 2425201 tcaatttgct ttcctcgctt taaaaatgcg tcaatatgca tactcaagaa ataaataaac 2425261 ttacggtcaa atgtgcaatc cagctcatgt tcagctattt cttttaactg ttttgtcatt 2425321 tgaatcacat cgtcttcaac gaatgtcagc aggttgtctt tttgaaaagc ttgatgatga 2425381 aaaaaacttc tgacatgcaa atggacatca gtcaagatgt actggttaat atcctttttg 2425441 gataaacctt ctttcataag cgttttcact ttttcctcaa tcaaatgata taagttaaat 2425501 gagaggtctt cgtcaatttt tgttgtttca tcttctacaa tcggagagat aatcgttgta 2425561 atattgacat attcagaaat ggctttgctt ctttgcatgt ttttgctgct ggacatccat 2425621 tcttgcttga tttcatcagg cagatcgcga acagtcagtt caataacttc atttctgtca 2425681 aggttatgca aaaatccgtg tgcgcaaact aactgaacat ttgatttcag ctgtccgaca 2425741 ttcccaaatt tcgcagagtg aataagcgca ttatagacat cgatatgcac actcagattc 2425801 ttcttaattc gctctgcttc tttccctaat aaaaacgtcg tcagatccac tctttcatta 2425861 agcgatcgtt cttcaagcga aggaatatga atggtcattg ggattcttcg caaaaacgtt 2425921 ttcaatagtg cagaactcgg attttctgta gtcgcacaaa taaacaatac gttcgatgtt 2425981 cgtttatgtt cagattctcc aagcctgtta taagaaccgc tgtcaataaa ataaaacagc 2426041 atttcttgtc cctcgggagg gagacggtgg atttcatcca taaaaagaat gcccccattg 2426101 gcctgttcga ctaaacccgc cttatcctcg gcagcacctg taaatgaacc ttttttgtgt 2426161 ccgaataatt gagaaagcaa taattgaggg ttgttgtagt agtctgcaca gttaaatgta 2426221 ataaatggtg cgccggcctt caatatgtca gagtaaatgg caaactggta aattcggttc 2426281 gcaaaaaggg atttaccgga accagtcggc cctaggagga gcatatgcag accgttcggc 2426341 ggataaaaga cagctgcttt tgcctgggag atcgctttct tcaaactccc ttttgcccct 2426401 atcataagct ctaggggatt cgtggaaatg tgttgatgat tttgctttga atttccggaa 2426461 aacgcctgaa ggtctttcac ttccatcatc tctgtatccc atttcttgtt gaataatttt 2426521 tctgctatct cgactgggat gtatcttaca ggaaatgttt taattttgat gacctttttg 2426581 gaccggacga gattgttcaa ttcaaagctg acattggacc gctccatttt cagctgctcg 2426641 gcaatctcct ttgctgaatt cccttgtatt tttaaaagat gatctaaggt tgaatcatga 2426701 aaattatgct tgagctgatg gtatatttta tctattcttc tcacgtctat catcctttgt 2426761 ccttattaga taagccatta acaagaatat ttcgaaactt tatagtccgc gttgagattt 2426821 acacgtttaa aaaggtctct atagcagatt gacaaagctg gcttttatgc gtatatgttt 2426881 acatgttgaa tcatttgcac ctcatattag tatgatagat gctcagttct ggagggccag 2426941 tccccttcaa aagtaataat cagtaaacag tttatcattc tcggggaatg taatgatgtc 2427001 aaaataatca atgacaaaaa atgaatctta tagatcatga caaattaccc aaatataacc 2427061 ccttaagttc gttcacaact aaaaagacgg acactctatg tgaccgccac agtattacaa 2427121 tttgcaaaac ttcgtcattt ttgcaatcca cattggaggt taaggaatct gtaagcttaa 2427181 aaactttatc tccgatccta tcgatttgat ccccctgccg gcctcaatca tagtgggtat 2427241 gcaattatac aaatcgttac cgattaaaac tagcctgtca gattgtccaa atgactttcc 2427301 tgttttactc tgctattcag gtagaatcac gagtgaaaaa tagagccaca agacatgtaa 2427361 cagcacttaa aatagtttta aaatttaaaa ataaaagtat ctattctttt aaatgttata 2427421 atatccgata aaactttact catcttttta ttactggagg aaaataaaat tgataggcaa 2427481 ttctagcaaa gacaattttg gccagcaaca gaaattgtct agaggcctta aaaacaggca 2427541 tatacaatta atggcgattg gaggtgcaat cggtacaggt ttatttttag gttcaggtaa 2427601 atccatccat tttgcaggac catccatttt atttgcttac ttgatcaccg gcgtattttg 2427661 ctttttcatt atgcgttcgc tcggagaact gctcttatca aatgcgggat accactcttt 2427721 tgttgatttt gtaagggact atttaggaaa catggcagca tttatcactg ggtggaccta 2427781 ctggttctgt tggatttccc tcgcgatggc tgatttaacg gcggtcggca tttatacgca 2427841 atattggctt cccgatgtgc ctcaatggct gccgggtctt cttgcgctta ttatcctgct 2427901 gatcatgaac cttgccaccg ttaaactttt cggagaatta gaattttggt ttgcattgat 2427961 caaagtcatt gccatactgg ctctgatcgt aactggtatt ctcctgattg cgaaaggttt 2428021 ttccgcagct tccggccctg ccagcctcaa caacctttgg agccacggcg gcatgttccc 2428081 aaatggatgg catgggttta tcctatcttt ccaaatggtc gtcttcgctt tcgtgggtat 2428141 tgaacttgtt ggactgacag caggtgaaac agaaaatccc caaaaagtga tccctaaagc 2428201 catcaatcaa attcctgtcc ggattttact tttttatgtt ggcgcacttt tcgtgattat 2428261 gtgtatctat ccttggaatg tgttgaatcc aaacgaaagc ccatttgttc aggtcttctc 2428321 tgcagtaggc atcgttgtgg ctgccagttt gatcaatttt gttgtattaa catcagccgc 2428381 atcagctgca aatagcgctt tattcagcac aagccgaatg gtctattcac ttgcaaagga 2428441 tcatcacgca cctggactat taaagaaatt aacttcttct aacgtgccaa gcaatgcgct 2428501 gttcttttca tccatcgcca ttctgattgg cgttagtctg aattatttaa tgcccgagca 2428561 agtcttcacg ctgattacaa gtgtttcaac aatatgcttc atttttattt ggggcatcac 2428621 ggtgatttgc catttgaaat atcgaaaaac aaggcagcat gaagcgaaag caaacaaatt 2428681 taaaatgcct ttttacccat tatccaacta tttaacactt gcatttctcg cgttcattct 2428741 tgtcatattg gcactggcga atgatacacg tattgctttg tttgtcaccc cggtctggtt 2428801 tgttttattg attattttgt ataaggtgca aacccgcaga ggacataagg tgaaataaaa 2428861 aaaagacaag ggatactcac tcccttgtct ttttatatgt gtcaaacact aaattaaact 2428921 ttggtttcaa atttcattca cttcatttaa gtgttaactc aaaccagttt tgatgccgaa 2428981 acctactaat attattccgg taattttttg aaacactttc tggaacttcg agtttttcat 2429041 ccattttttt gcgtaatcaa taatataaac aagaaacagg aaccacaaca ccgctaataa 2429101 ggttaggatt gaagctaaaa tgatgagctg ctggtttata tttccgttca aattgataaa 2429161 ttggggcatg attgtaacat acaccaaaac agttttagga ttgagaatgt tactgagtga 2429221 tccctgcata aaggaagttt tataataacg tttcggagaa cttgccatat tttttgcttg 2429281 ggattgcatg tcatctaacg aaaacatact tttagcaaaa aaacttttta cacctaaata 2429341 aattaagtat gccgctccca aatatttgat cgttgtgaaa agaatcactg actttgcgat 2429401 taccactgat aatcctaaaa tggcaatcac cgtccaaaag gaaagtcctg tcgccaatcc 2429461 gagaatgtta taacggccgg ctttcggacc atacctaagc gtatttttca tcacaagcat 2429521 cgtatctgcc cccggtatga taaccatcat ggcagcgatc ggtatgtatg cgagtaagct 2429581 gtgcattgtt ctctccccct ttaaaaatcc cctcaatcat atagtgacta caaaagtaac 2429641 tacttataaa agtgtatcaa tgcgtttgga ataaatcaat atgatttgtt aaaatagcga 2429701 ttactaaggc agcgattgct ctttatattg gaggatatat gaaagaaaat atgttagaca 2429761 ttttaaaaaa cctcaatttt acagaatatg aatcgaaagc gtatttagca ttattgcaag 2429821 aatcaccttt aacaggctat gccgttgcca aaaaatccgg agtgccccgt tctaaaattt 2429881 atgaagtatt ggaaagtctt gtcataaggg gagatgtttt tgtcagtcat ggaaatacgc 2429941 ctcagtatgt tccagtcccc gcaaaagaac tgattaaaaa ccgccggctc aaagcggaag 2430001 agcattttga tcaggctgag aaatattttg aaaagttcga gcagaccgca aatgaccggg 2430061 aaaacatctg gaatatcacc ggccgcagtg aaattcttga aaaggtgaag gcttgtatct 2430121 tatctgccaa aaaaagaatc ctcttagaaa tatggaaaga ggattttaag gagatagaag 2430181 cagagctcaa acaggcggca gaacaaggcg ttattgtcac cattattgcg tacggagaca 2430241 tcgtatctga ttttgccaat gtttaccttc atgatatgag cagtgaaatt acagaagagt 2430301 atgacggacg gtggcttgtc tatagcggag atgattcaga agtagtagcg ggcattgtct 2430361 cacttggcaa cgacagccgt gctgcatgga cgatgcatgt agggttagtc atgcctatta 2430421 ctgaagtgat cattcatgat ctgtacctca tggaaattct gaaaaagcat agagagcttt 2430481 tagaagagag cttcgggaaa aatctcatcc agttgcgccg taaattttct attcactcag 2430541 atttcaaaaa acattatttg gaataatgtt tgtcatctct taccccaaaa acaaggcttg 2430601 tacaaaacaa gccttgtttt tttatgcata aaccccccat gctgatttac ttctctcttt 2430661 taaaaaatgt gattctgcgc aaactatttt tcagcctgcc gcgtctatcc taggtaacag 2430721 cctacgatat acgtatattc aaaaaggagc cctttattgc aatgaagaaa aaacaaacaa 2430781 caaaagcgtt gcttgtcaca tgcataactg accataagca agatttctac aggttggctt 2430841 tcagttatgt gaaaaatcaa gatgacgcat tagatattgt tcaggaatct ataaaaaaag 2430901 cgctgagctc agttgaaacg gtcaggaacc ctgagacgat aaaaagctgg ttttataaaa 2430961 ttttagtacg gacagccatt gactttttgc gcaaacaaaa aaagataaga gtgatggacg 2431021 acgaaacgat agaattttta agcaaaggaa aggaagacca ttacaaggat actgatctcc 2431081 atgaagcgct tgacgaattg ccgtaccgct ataaaaccat tattatttta cgtttttttg 2431141 aagacctcaa attagaagaa attgcggaaa ttacaggaga aaacacgaat accgtcaaaa 2431201 cgcgcctata cagagcattg aagctgatgc gcattcagtt gacgaaggag gatctttctt 2431261 aatggataag agattacagc aattaagaga agaatataaa aatgttcaga ttcctaaaga 2431321 attggatatc attgttgaaa aagcccttca gcaagaacca aaaaagaaaa gaatcgttat 2431381 gtggccgaca tcagcagcaa tcgctgcagc tattttattc actgcgcttg ttaatatcaa 2431441 cccggacgcc gctcaggcta tgtcaaagat ccctgtcatc ggcaaaatcg tcaaagcgat 2431501 cacctttatt gaaatcaaag aggaaaaaga ccaatcaagc attgatgtca aaacacctgc 2431561 tttgtccggg ctttctaata aagagcttga aaacagcatt aacgagaaat acttgaaaga 2431621 aagccagcag ctgtataaag agtttataca gtccacatcc aaaaacaaaa aagggcatct 2431681 cagcatctac agtgattacg agacggtcac agacacgcca gatttactct ctatccggcg 2431741 caatattgaa acaacacaag catcttccta cacacaaagc cgttatatta caattgacaa 2431801 aaagaatgat attttactta cattaaaaag cttattcaaa gatgagcgct atatcaaagt 2431861 catcagtcaa aacatcaaag aacaaatgaa acagcaaatg aaggaagatc caaataaaat 2431921 atattggctc actgacgaag atgcagaacc gttcaaaacg attcttcctg atcagacgtt 2431981 ttacattact gaagaccata aacttgtgat ctcatttgac gaatatgaag tcgcccccgg 2432041 ctatatgggc gttacagagt ttacaattcc aaccggcgtc atttcaaact tgctcgtggg 2432101 agaacgttat attcgataaa ataaaaacat ccatctaaga ttatggatgt tttctctctt 2432161 ctctattcga ggtcgtaacc ccgctatcaa aaacaacgag aatatttgca tactattgga 2432221 ggaataccca tgtatcacaa gacacagcat catcgataca ttcctggact tgatggcctt 2432281 cgggctttcg ccgtcctgtc agttatcact tatcacctaa atttcaattg ggctaacggt 2432341 ggttttatcg gggttgatat cttttttgtt ttatccggat atttgattac atctattcta 2432401 ttaccggcat atggaaatga tatcaatctt gattttcggg atttttgggt gcgccgcatt 2432461 cggcggcttc tcccggcagc gtaccttatg atcttttcca ctgttgtgtg ggtcgtattg 2432521 tttgatcgag aactattgca cactgtacgt ggagatgcga tctcttctct cttttatatg 2432581 agcaattggt ggtttatttt tcacaagcta tcatattttg atagtttcgg ttccccatca 2432641 cctctaaaaa acctttggtc gctggcgatt gaagaacaat tttatatcat atggccgatg 2432701 tttttagttg ttggaatgta cataatgaaa agccgcgcca gattggctgc ggtgatatca 2432761 ttgcttgtgc tttgttcagc cgtgatgatg agcgtactgt atgaacctgg cggagatccg 2432821 agccgcgttt actatggcac agacactcgt tcgtttgaac ttctcatcgg atgtgccttg 2432881 gctttggtat ggccgatgaa aaggctgtct tccaacaggc tgccaagcaa actgaagcac 2432941 actttgcacg ccactgaatt tttggcattt tgtattttag tgttgtgtgt ctatttcaca 2433001 gatgaatacg agccttttct ttacagaggc ggaatgctat tcattagcgt gactgccgca 2433061 atccttattg catgtgtttg ccatccgagc agctttttag gcaatctgct ttcatggagg 2433121 ccgcttcggt ggcttggaac gaggtcttac ggaatttatc tttggcacta ccctgttatt 2433181 gtgttaagca cgccagttca agaaatcgga aaccctgttt tttggcatat cgtgctaaag 2433241 gtcattgtga catgtatact tgccgagctc tcctaccatt ttattgagaa gccgatacgg 2433301 acacagggat ttaggtcatt ttcccgccgt gtttttatac atagaatcaa ggaatggaaa 2433361 acgacatctg tcatcagcaa aatgtcaatt ggtttcatta ttttcgctat acttattttt 2433421 gcaggcgggc tgtcagggct agccggcgag caaaagcacc ctaccaaatg gacctatagc 2433481 tcacaagaaa caaatgctga caccagccag gcttctgggg ataaaaagaa cgctgcagca 2433541 gataaaaaac acaatcctga acaaaagaca acagattcca atcagggtca aaaggaaaac 2433601 aaagatagtg ggcaagagac tcataaaaag aaagacacgc aatcccaaca gttgaaaaaa 2433661 ccagcagaca ctgcgaaaga agttttagct ataggagatt ccgtcatgct tgatatttct 2433721 tcacacctgc gtcagtcatt ttcaaatgtg acgattgatg gaaaggtagg gagacaaatg 2433781 tctcaagctt tggaactcgc aagggaatac aagtctttta atcagccgaa caaggctgtc 2433841 atcattgagc ttggaaccaa tggctatttt acaaacagcc aaatcgaaca actgcttcaa 2433901 tctttctcaa aagctcatat ttatcttgtc aatacacggg ttccccgcca atgggaaagc 2433961 aaggtaaatg aatctttgca gcaacaggcc cacgcacatc aaaatgttac gttagttgac 2434021 tggcatacag aagctcttca gcatccggaa tattttaccc ctgatggtgt tcacttggtt 2434081 cctaaagggg caaaaacttt gactgctctt attgttcagg cgatgaaatc gtaaaaaaga 2434141 gatcctatac agatcacttt tttactttag tttctgatcg ttgattatgt cttctttcag 2434201 caaggcagcc cttatgttta catgccgttt acgtaagggt aagccaaaat tgaatggagg 2434261 gatgataatg aaaggaaatg aagaacatga catccaaaaa gagttgaaac gatatgagct 2434321 ttttttcaaa aaacgatata aggttcttta tacagtaaac gattttatca tcggtgctat 2434381 gtttctcgtt ggaagttttt tcttttttta tgaccggtta atgtcggcag ggatatggct 2434441 gtttgcgatc ggaagtttgc tgctgttaat caggccgacc attcggctga ttcatgactt 2434501 tcattaccgt aagcatgtgg aacagcaatt caagcatcaa tcttcaacag atgactgatc 2434561 ttaaggaata agaaagaaca aaatgccaaa agcctgagtc gaaaatcaaa aacaagactt 2434621 tcagactatt tatttttaaa aacaaggtaa aaagaactaa acttttgcct ctgcatgccg 2434681 atatgaataa taaggccggc gcgatactcc ctataacatc cttttcagta gatttcatta 2434741 tcgtgccggt tttctcatat gcaaagcaat cccgccaatc agattggcgg gattttatat 2434801 tttacattcc tgtccaaacg tctttcacat aacgtctttg atcttgcagc ttttgcagcc 2434861 atacagctga ttcttcctga cttgctgctt tttcagcttc atatgccaat cgcaaagttc 2434921 tctctacatc aggagccatt tgcgatccat caccgcatac gtaaatatga gccccttttt 2434981 caatgagtgt catcaatttc tgcgtatctt gcttgagcaa gtgctggaca tatccttttg 2435041 gttcgttttc gacgcgcgag tagcatcggc ggattgtgac caaaccgtcc tgttccgctt 2435101 gatccagctc ttctctgtaa aggtcgtcat ggtccgggcg gcggcagccg aagtataaaa 2435161 gtgcttcacc aagggtgctt ccttccttct tcaaaaccga tcttgcctga ataaagcctc 2435221 tgaatggcgc aattcctgtg cccggcccga ccataatcat aggcgtttca ggatcattcg 2435281 gcatctgaaa tccggactgc ggcgtacgaa tgaagcaagc tgctgcatca cctgtattca 2435341 attctgctaa ataattagag gcgacacccc ggtattcacc tcggccgctc catgctgagg 2435401 ctttcacaac tcctaccgtc atgctcacga tatttgcatg aactttcggt gagcttgaaa 2435461 tggaatagta tctcggtttt agtgatggca aaagtgctaa aaaccgttca aacggcattt 2435521 cgcaagcagg ataatcctct aaaaaatcaa gcatggtaag acgttttgca agtacctgct 2435581 ctttgtaaat gccatcatct gaaacgagct gttccagctc tttttgatgc ggcggacaaa 2435641 ctgtataaga ggccagctcc cgaagctgaa gccttgatgc cggttcctgc agctctacat 2435701 aggacgacaa taaatccact actttgattg gccgatccat cggcagatga gccatatgag 2435761 cgcttccgct tacttttatc acatgattgg actgcaaacc gaatcggctg agaacccgct 2435821 gaacaagctc cctgctgttc tttggcagga ttccgatatg atcgccttct ttatatgttt 2435881 taccagccgg aatttccaat tcaatatggc gggttgaacg cgtgctggca gctgtctgga 2435941 gttctcgatt ctctaacaca atcccttcaa acgcgccata tgctttagca accggcgttt 2436001 ccgtcgcttc actgagaaaa gtaatcgata atgaaggcct gtcttctttc tgggctattt 2436061 cgttaatatc aaatgcgtcc atcgtttcct tccagaagcg gttttcccaa gactcgcggt 2436121 ggctttcaaa atcatcggcg gcgtcacctt ccccaatcgc tgttaaacgc gatgccccct 2436181 ttgctttcat catgtcatca atcaggcggg gaatccgctg atacgtgctg gcccagctcc 2436241 ggtttccgca gccgaatacc gcataggaaa cacctttcaa ttggccttcc tcaagctctt 2436301 tcagccactc tacaaatccg gcagcattat caggcggcgc cccattataa gaagccgtta 2436361 caatgacgac tgccccttct tcagggagct tgccgatata atcatcaagc ggagccgttt 2436421 cagctgtaaa gcccatctgg cggccttgag cagccagttc accggctatt ccctcagctg 2436481 tcccaagatt tgaaccaaaa agaacaagta aaggtgtgcc gtgtttaggt ttggtttctt 2436541 ttggctttgt ttctgctttg atgtctgcct gttcttttct ctgtacattg attgccgctg 2436601 tttttcgcgg tttcacagta attttaaaat catccggctt gatcgttaat gcttctttga 2436661 tttttagttc gtagccagta tggtttatca attcaaaatg ctttaataca agaccgagaa 2436721 ccattgtcgc ttcttgaaga gcaaactgca tgccaataca agcgcgctgt ccgtttccaa 2436781 acggcttata cgcatggtga gggatacttg aaggatcctc aaaccgttcc ggacggaaat 2436841 cttccgcatc cggtccccaa gcgttttgat cccggtgcag ttttggaatt aaaacagtga 2436901 ctggctgccc tttgctgatc ggatattccc cgcctagaac agtatcctcc ttcgcatata 2436961 gagaaaaagc cggagctgtt ggatacagtc tgagggtttc atttaaaacc atccgaatgt 2437021 atttgagctg ctggatttgt ttatattcag gcgtgtcatc cgttaacacg cgatccgctt 2437081 cctcctgagc ttttttcagt ttttccggat gtgtaagcag acaataaatc gcaaaggata 2437141 gcaacccgct tgttgtctca tgtccagcaa ttaaaaatgt gatgatttgg tatcgaatgt 2437201 tttcgtcatc cagcgtttca cccgttactg gatctttggc ataaagcatg agagacaaga 2437261 gatccttaat gttttcatcc ggattcgcct ttcgctccgc tatcattcta tcaaccaggg 2437321 agttcatgac ttctatatcc ttttggaact gcagcttcgt tttcaccatc attttatctt 2437381 gcaggcccag tcttttcgat tgattcatcg cctcttttaa ggcacggagc atactggtga 2437441 taaacggatg ctgtgaatca cggtaaaagc tgttgaatcg atagttaaac ccgcataacc 2437501 caatcgtatc aagcgtcaga cgtgtcatat cgtccgctac atcaatttct tcattagggt 2437561 ttaaccggct ccacttttga atcagctggg ttgcgatatc cagcatcata gaatgatagc 2437621 ctttcatcgc tttttgacta aaactcggca gcaaaatgcg gtgggctttt tgccagttcg 2437681 gttcgtgcgt ccagcttgta aataagccat ctcccccgaa ctcacgcacc ttttgcaagc 2437741 ctttgccaag gttcttgtca aagcgttttt catcacacac ttcagccaca agattgtggc 2437801 cggacacaaa aacactggat actcccggaa aatcaaaacg gaaaatcggt cccaattcat 2437861 cagctatccg ccataaggat tgagaaagct gttctttttc cagatgcgga agatttttta 2437921 aaggtccgta tgttttgggc tgaggtattg cgcttgcctg tttcattaac atctcccttt 2437981 cctatttttg tgatgaatga agcttaatgg cgtcccagca gcattgttcc aattcagtaa 2438041 ttaaatcagt gtccatctct atatcacctg tttgaacgag ctgatatatc ttgagaaacg 2438101 cccctaatac aatcgcaatt aacacattag agggcaggct gcgaatcacg ccttccgctt 2438161 ttcccttatt aaaatagtca tcaagcattt gagtcagatt ttctatcatt tttttgcttg 2438221 tatgatttaa gtaatgagcg tcttttttgg tttcaagaaa aaaaagcgca tagtcgctct 2438281 ctttcgtaaa ctgaacgaga cagcaaaata cgtggtgaaa gccttctctg acaggcaatt 2438341 ctgaaacgtc ttgcttcagt ttttccgtaa atcgctggat gctttcttga aacagtacgt 2438401 taacgagtgt ttctttgctg tcaaaataac gatagatcgt tcctgtccct acatgagcac 2438461 gttcagctat cataggaata gtggtagcgt caaaacccct ttccgtaaaa agtgagactg 2438521 acgctttcat aatcatgtcg tatttactgc tggatgcgga tatcatgtaa tctgacaacc 2438581 tccgattcgt ttacggaatg aatattcatt ccttttgttc acaaagaatg tctgccctgt 2438641 ctgatatcac ctctttgttc tttcttctgt tataagttta tatgaaaaaa acttttttta 2438701 atataaagta tatgcaaaaa ataaaaaatt aagaaaatat acccaaatcc taatacgagg 2438761 atcttggata tatttcccga gaaatttttt atttaacagc cacaatacat agacaggaag 2438821 cacgcctgat aacagaaaga tccctgaaat gctggtcttt cagcagttga atatacgttt 2438881 tctctttttc accggtattt gtgtcaatac tgatataaaa ccggccgtca atttgaagca 2438941 ccctgtaaat ttctcttaat gcaagcctaa tatcggtgca gctttgaacc gtatgtaaag 2439001 aaaagacttt attaaaggta cggtcatcaa agggaatgtc ctctggatag ccatgaaaaa 2439061 cctccccgtt ccccatgttc tttcgattcg cacgtgatat ctgtcttacc tttcgttttg 2439121 aaggatcaat gctttttagg ctaccctttt ttagtttctt ggttatgctt ttaaagacag 2439181 tgccgtttcc aattccaatt tctaaaattc tgtcattttc ttgtatatct atagagtcaa 2439241 tcatcatatg ctcaattgtt ttggttagct tatatttccg agaaaataat ttccaaaaat 2439301 ccgatcgttt atagagtcta ttttctagca ttttaaacac ctgcttttgg tttcctatgt 2439361 ttatttatta tcttaaaaaa ataaacatca tcttcatttc taaaagtgaa ggaaggtacc 2439421 aactagacgg caatgtattg aaaaatgttt caatagaact aaactttttc atttttttcc 2439481 gaaaaaaaag cagaaaacat aatgttttct gccctctttc taatgccaat gataagggaa 2439541 tacatacagc ctttgctgct gcattgccat cagcctctgc tgtcggaatg gatttccata 2439601 accatgtttg aaggaatgcg gcatggacgc ataaccatgg ccaatcgacg gcagtctttt 2439661 ttgataatcg ttcatcatgc catcacctgc ctcacaataa cgttgattta ctatatgcag 2439721 gcgcgcattt tcttgacagc tatttcgcta aacttggtcc ttctccattg tataatgcat 2439781 caatagttcc attctaagca tatgccattc ccccttcagt ttttttcgtt gcttttagcg 2439841 ccagtttgtt aaataaagat gctttaactg agactctttc atttcatcat aaatttgttc 2439901 aatctgctgt tctcgttcga attcttccag gcttttaaac cgttttttaa tcgttaacgt 2439961 taaaaagaat aggttaatcg tcatatcgct cacccccttt caaagtccgc atcaagcgaa 2440021 ataacccgcg gcacaaccct tctgccgcgg gcaaataaaa accgcagaca aaagaagaca 2440081 ccaatgcctc tactgcctgc ggggagttgc gtatgtccga ctattccgaa tttaatgcgt 2440141 gcgataagca tcggttaagg aaggacacga actcttccac aggctgaata aaccatgaac 2440201 ttttacatgt gtatcacgta caggttgacg tcgttgtctc attgtcattt tggttcagcc 2440261 tcctttgctt ttttcttact ttgtaagtat atccaccaaa ttccattttg taaacatctt 2440321 tttctaaaaa tggacggaaa ttgtgcaaat catcgaatgg atttgcccgt tggtcatgac 2440381 acctgcttca tttcttttct ggagcggtct ttcttatgat atgcaataaa ataaatgaga 2440441 ccgacaaata cagctccgcc gatgacatta ccgataaaag ccggaatgat gtttccgatg 2440501 aactgccccc acgtgaatga gcctgcaaaa atggcagcag gaatcacaaa catgttggcg 2440561 acaacgtgct gaaatccgat agccacaaaa gccatgattg ggaaccagat gccaaggatt 2440621 tttcctgctg cgtcttgggc gccgaaagaa agccacactg caagacatac aagccagtta 2440681 cagccgatgg cggaaatgag aaccttgcca aagctcatat caagctttcc ttgggcaacg 2440741 gcaatcgttt tttctaaata aggacctgtt tcagtcaatc caaccaaatg cccgaaaaag 2440801 taagcaacaa acaatgcgcc gattaagttc ataattgtga cgattcccca gttaatcgct 2440861 aactctttta ctgatatttt tctcgaaaat aacgccatcg caactgacat catattgcct 2440921 gtgatcagtt cagcgccagc gagaacgaca aggatcaggc cgactggaaa tactgctgca 2440981 ccaatcaaac tggacaggct cccccattct ttcggaagat cgccaattac cctgatatca 2441041 agcaaatacc caagcgcgat aaatgcaccg cctaaaaacc ccagcacaag cagtgacggc 2441101 agcgggagct ttattttttt catccctgct tcaattgctg cttccgctat ttcatccggt 2441161 tttcgaaaag ccataataaa acgcctccat tacttcttct tttctcacag ttatgcaaga 2441221 aaggcaataa aaaaggcagc actcaaataa cctgtgtcaa accaggcgtt tgaatgctgc 2441281 ctaacttgta tgcataccca tacaacaata tcaagcagta tataagatat tgaaagagaa 2441341 tatatacagt tcgtgcatac attccattgc tttagccttc tataactgta gcaacatcat 2441401 atcaaatgtg acaaatttgt gtcaatgaca aatatactag ctttgcagag cttctttttg 2441461 ctcatctatt tttcggtcaa aaacaaatac agatacagcg atgttttcct caattttaat 2441521 atcagaaaac aaatggacta gcttagctcc cataagttcc tccattcctt ccggtgtttg 2441581 tttggaataa aggtcttgaa ttaggcttgt ccgggccgca tgtaccatct ctcttccttc 2441641 aggcgtgcgg gcaataaact gctcgcttgc actcagattt ccgtatagtg ttgaaactgc 2441701 catgttttct acaaatacag tatgaattct ctcaggccct tttccgaaca attctttgcg 2441761 aagttttcga ataatatcat tgaattcatg aattttttta gacatgctga ttaccccttc 2441821 cgatattgcc ttataaaggc ttttcccggt tcccctcagg acatttcact tggttaaaat 2441881 tttcctgcca tattgtatta taataaatat cacattataa taaaagcagt gttgatggat 2441941 ttgtaatagg atcttgttat gagtctatcg ttttataaaa atcaaggatt ggtctgttag 2442001 taagacttgc tagtgaacta ttccgccatg tgtgtttaca ccttcttaga attaagggca 2442061 ggtgtatcta tacatggctt tttttgactt cttgaaagaa agatggaggg gaatatgaat 2442121 atgatggacg ttaagtcgat cagtgtccgt gtagacggaa cagaaattca agcacgagca 2442181 ggggccacaa ttttagatat tttaaatgaa aacggaattg agtacccgca gatttgccac 2442241 gtaccagagg ttgacccgat tcaaacttgt gatacttgca tagtagaggc aaacggcaag 2442301 ctggttcgtt catgcgcgac ggttgcagaa aacgggatgt ctattgatct ttcaggaaat 2442361 cgagtgaaag aagcgcaaac cgaagcgatg gaccgccttc ttgaaaatca tttgctgtat 2442421 tgtacagttt gcgataacaa caatggaaac tgtacgctgc ataatacagc ggaaatgatg 2442481 gggatcgagc atcaaaaata cccatacacg ccaaaagaag atccttcttg cgcggttgat 2442541 atgtctcatc ctttttaccg ctatgatcca aaccaatgta ttgcctgcgg ccagtgtgtt 2442601 gaggtctgtc aaaaccttca ggtaaatgaa acactctcaa tcgactggga acgcgaacgc 2442661 cctcgcgtca tttgggatga gggagttccg atcaatgaat cttcctgtgt cagctgcggt 2442721 cagtgtgtaa cagtatgtcc atgtaatgca ctgatggaaa aatcaatgct cgggcaggct 2442781 ggttttatga caggcattaa agaggacgtc atggaaccga tgattgatct cgtgaaaaat 2442841 gttgaaccgg ggtatggcag catttttgcc atttctgaag tcgaagcggc aatgcgtgaa 2442901 acgagaacga aaaaaacgaa aactgtatgt acgttctgcg gtgtcggatg ttcatttgaa 2442961 gtatggacaa aaggacggga tattttaaag atccagcctg tttctgatgc tccggttaac 2443021 gcaatttcca catgtgtcaa agggaaattc ggctgggatt ttgtcaattc aaaagagcgg 2443081 atcacaaagc ctttaatccg taaaaacgga gcctttgtgg aatcttcttg ggaagaagcc 2443141 ctcgatcttg tcgcaagcag attaggatca attaaagagc agtacggtaa aggctctgta 2443201 gggtttattt cttcttctaa aattacgaat gaagaaaact acgtcattca aaaactagcg 2443261 cgtcaggtat ttgaaacaaa caacgtcgat aactgctcac gctactgcca gtctcctgct 2443321 acagacggat tgttccgcac tgtcggcatg ggcggtgacg ccggcacgat taaagatatt 2443381 gccaaagcag gcctggtcat cattgtcggt gccaatccgg cggaaggaca cccagtgctc 2443441 gcaacacgcg tcaaacgggc acacaagctc cacggtcaaa aactgattgt tgctgacctg 2443501 cgtaaaaatg agatggctga gcgatctgat ctgttcatca gccctaaaca aggcacagac 2443561 caagtttggc tgatggctgt tacgaaatat atgatcgacc aaggctggca cgatcaggcg 2443621 tttattgatg agaacgtcaa ttactttgaa gattataaag aaacccttaa aacgtatacg 2443681 cttgattatg cagaacgcat cacaggcctt tcaaaagaaa acatcattca aattgctgaa 2443741 atgattcgtg atgctgacgg cacttgtgtc ctttggggaa tgggtgtcac acaaaataca 2443801 ggcggttctg atacatcagc agccatttca aacctgcttc tcgctacggg caactatcgc 2443861 cgtccaggtg ccggcgctta tcctctgcgc ggacacaata acgtgcaagg cgcatgtgat 2443921 atgggaacat tgcctggctg gctgccggga tatcagcata ttacagatga caaagcacgc 2443981 gctaaatttg aagaggcata tggtgtcgag attgatggaa agcctggttt agataatatt 2444041 caaatgcttc atgccattga agaaggaaaa atgaaagcta tgtatcttgt cggtgaggat 2444101 atggcactgg tcgattcaaa cgcgaaccat gtgcatgata ttttatcaag ccttgatttc 2444161 ttcgtggtac aggacatctt cctgtcaaga acagctcaat atgctgatgt cgtcttgccg 2444221 gccactcctt cacttgaaaa agacggaaca tttaccaaca cagaacgccg tgtccagcga 2444281 ttgtatcagg cgcttccgac gcttggtgac gcaaaaccgg actggtggat tattcaagag 2444341 gtggcaaacc gtttaggagc gaattggaat tacagccatc caagtgacat tttctctgaa 2444401 atggcgagtc tttctcctct gtttgccaaa gcaagctatg aggtgcttga aggctggaac 2444461 agcttcctat ggggcagctt cacaggtgaa agcacaccgc ttctgtatga agacggattt 2444521 aatttccctg acaaaaaagc ccgctttgcc ctttctgatt ggaccgagcc agcggcattt 2444581 ccggaggaat atgaccttca tatcaataac ggccggatgc tggagcattt ccacgaagga 2444641 aacatgacaa ataaatcgaa aggcatccaa gcgaaagtgc cgaatgtatt cgttgagatc 2444701 tcacctgagc ttgcacaaga gcgaggtgtt tgtgacggtt cgcttgtacg gctcgtttct 2444761 ccgttcggag cagtcaaatt gaacgcgctg atcacagacc gggtacggaa aaatgaactc 2444821 tatttgccaa tgaactcgac agacaaggag tcagcgatta acttcttgac gggccctgca 2444881 gctgataaac ggacgaacac gcctgcttat aaacagacaa aggtccgcat ggaagtgctt 2444941 ggcggctgtg aaacagcgcc gcttccaaaa acaaatccgc gcaacaaaaa acggcatccg 2445001 caaaacggag tcgaagcaga aagaaaatgg aaccgccctg gctatgtaca tctgactgat 2445061 taaacgatag gaggaaaacg aatggccact ccgattacga cgatcaaaaa agaaacaaaa 2445121 acagctgagc aaattaagct tgaaaaaata gaagaactga aagagctgct ggcggaaaat 2445181 gaggacgccg tctctaaaac gatgacgtta atgaatgaac tcaatgatct tggaattttt 2445241 gatgcggcaa caagcatgct cagagcgaag gaagacattg ccaagattgc gcttggccaa 2445301 gtttcccgcg agcctgtcac caacctcatc aacacgatga tggccgccgg aggcgcattg 2445361 acaaaagccg atcctgagtt tacagcaaag cttttagaaa gcgtaatggc tgggactgaa 2445421 caggcacaaa gctttttaaa agaagacaag aaagtcggga ttctcgacct gttaaaagca 2445481 atgaacgatc ctgacatcaa cagagccgtc gggttcggcc ttcagttttt aaaaggcatg 2445541 ggaaaagaac ttcgagaaca ataacagaaa aacagccatc tctgatgatg gctgtttttt 2445601 tattcgtcgg cttcttccag acgcttcttg taaataagtg aacggtcagc gcaaaagaag 2445661 gcaccggcta aaaatacgca atccgctaaa aacatcgtcg atttctggcc taatgttaag 2445721 ccttgatcag ggagaactgc gcctatatat aaaaaagtgc tgactgcaag caatgtaaaa 2445781 gcaaaatgct tgtagtcttc ttttaaagat ttcattctat ttttgttcaa aagaatcacc 2445841 tgccagattc atagtatacg actattataa tataatccgg cggcttacag agaaagtaat 2445901 tctatccatt tgttatatat tttcaagcgc ttggccgata tcttccaaca agtcttccgc 2445961 atcttcaatt cctacagaaa ttctgatcaa gccgtccgta atgccgagct caagccggcg 2446021 ttctctcgga atagaggcat gtgtcattct tgcaggaaca gaaattaagc tttcaaccgc 2446081 ccccaggctt tcagcaatgg taaacagttt cagatttcct aaaaacgcat caacccgttc 2446141 ttcactgcca atatcaaagg agatcatgcc gccgaagccc gctccttgcg tttttgcaag 2446201 ctcatgtccg ggatgatttg aagaaccagg gtaatataac gtttggacag cagggtgatt 2446261 ctcaagaaag cttgcgattt tccgcgcatt ttgatcgatc gcttccattc tgagtcccaa 2446321 cgttttgatt cctctcatta acagccagga atcttgaggg ccgagcacgc cgcctgtgga 2446381 gttttgcaca aaatgcagct cttctccaag ctctttcgaa gctgtcacaa ctaaacctcc 2446441 gacgacatca ctgtgtccgc caagatattt tgtcgcactg tgcagtacga tatcagcgcc 2446501 taaagtaagc ggctgttgaa aataaggagt attaaaggta ttgtctacga taagcagaac 2446561 acccgctttt tttgcgatat cagccatgag cgtcaggtcg gtgattttga gcaacgggtt 2446621 tgtcggtgtt tcaatataaa ttgcttttgt attagggcga atcgcttttt caacttcttc 2446681 cctgctgctc gtatcaacaa atgttgattc aatgccaaga cggttaagca cctttgtcat 2446741 cacgcgatat gttccgccgt acacatcatc agtcaacacg acatgatctc cgctgttaaa 2446801 cagcatcata accgctgtaa tggcagccat tcctgagctg aacgcatagc ctgcttcccc 2446861 gctttccagt tctgtcacaa gtgcttcgag agcggttcga gtcggattgg ccgttcttga 2446921 atactcgtag cctgtatgct gccctgcttt cggctgcttg tacgtgctta cttgataaat 2446981 cggcacggaa actgcgcctg ttttctcatc acctgtgatt ccgccatgta tcatcaatgt 2447041 ttttttcttc atatcagatg cctccttcgt atatttgttt gctgatatat cgatcgctgc 2447101 tgtcaggaaa tactgtgaca atgttagttc cagcggatgc ttttttcgct tcctccaatg 2447161 ccgcataaag cgctgcacct gaagagcttc cgatcagcag gccttctttt tctgccgctt 2447221 ctttcacaag tctaaacgca ttctcatctg ttacggtgta gatctcgtca aaatggctct 2447281 tatccatata atcggggata aactccatgc cgatgccctc tgttttatga gcgtggggct 2447341 ctcctccgtt taaaatcgag cccaccggtt caacaatcac cgttttgact gctggatttt 2447401 tttcttttaa gaaggaagct gtccctgcga atgtgcctcc tgatcctgcc cctgcgacaa 2447461 atgtatgaat attcccgtca agcgcttccc acatttcagg tccaagcgtc ttatagtaag 2447521 tcgatggatt tactcggttt ttaaattgca aaacgcaata agaattttca atttcagtct 2447581 ccagctgaat ggctttttga atggctccct gcattccgtc ttgacgcggt gtatgaatga 2447641 ttgatgcgcc aagcgcttgc ataatttgct gtttctctct gctgaaatgt tcagggacac 2447701 agaaaatcgc tttcagccca tattttctgg cacttaacgc aaggccgatc cctgtattgc 2447761 ctgccgtagc ttctataatc actccgccgg gtttcacttt gcctgaatcg agcgcgtcac 2447821 gaatcagcat atctcccagt ctgtctttga tgcttccccc tggattcatc atttcaagct 2447881 tggcatacac cgcgactcct tctggaacat caaagttctt caagcggaga agcggtgtat 2447941 tcccaatcag ctcggtaatg tccgtaatca ctgtcatata tgtcctcctc cttaatagag 2448001 gttgttttta gagaaaaacg gaggagaacg ttctccccgt tttaatgaat tcgtttgatc 2448061 acctttaaca caagctctgt tgaatgaaca gccgcctgct ctaaaaattg gtcaaatgaa 2448121 acatgtgatt ctttgcctgc gatatctgat aacgctctga tgacgacaaa cggcgtttta 2448181 aattgatggc atacttgagc cactgccgca gcctccattt caaccgcgta cagatcagaa 2448241 aatctcgcac gcacctcttc aacccgcttc ggatcgttca tgaaagaatc gcctgttgca 2448301 atcgttcctt ttgcaacctg aatgccgtcg agttcagata ccgcttcttc agtgatgctg 2448361 atcagctttt catccgccgc ataagcagcc ggaagacccg gcacttggcc gtattcatag 2448421 tcaaaagccg ttacgtctac atcatggtgg cgaacgtcag tggaaatgac gacatcccct 2448481 acattcaatg tatgatgaaa tccgccggct gagcctgtgt taatgacata atcaggcttg 2448541 taacggtcaa gcagaagcgt cgtgctgata gcagcattta cttttccaat tcctgatttt 2448601 aaaagaatca cttcagttcc ttcatattcg cctgttgtaa attcacagtg tgcgatcgtt 2448661 tctgtttttg cattttcaag tttgtttctt aagatggtaa cttcctcttc cattgctccg 2448721 atgactgcta gtctcatcta ttcacattcc cttcacttta ccgtttgatc gcctccatta 2448781 tccacacgaa gtcgttttgc tgagtgaatc ggactgcaaa accttcagct gtaaacattt 2448841 ctttcaacgc atccaatgta ggataatgct ctgtctctaa atcatttgca agctgataaa 2448901 agccttgaga acgggcttta tcgatagcct gttgatacgc ttgcgcattt tcaaagacgg 2448961 tatcggcaaa cactatttta tcatgcaagt gaaggtattt gccatattgc tttatggcag 2449021 cccgcttttc ttcgtcagtc aaatgatgaa aagcatatga actgacaatc gtatcagcct 2449081 gaaatggcgg ctcagggaat gtcaggaagt ctccatcaac gatttccgtc ctgcctgaga 2449141 gcttgtcaga agccagttta cgcattgctg gagaaggttc gattccaaat acagttttgc 2449201 ctgcatcgag cagcttagct gtcaaattcc cggtccccgg gccaaattct aacacatgcg 2449261 ttccagattt tctgacgatg gcatcaagga tatgatcgta gcctctgaac gcttctttat 2449321 actgaatatc taaaccttgt actgtttgat cataagttgc tgcccaatct tcaaagagag 2449381 ggataaattc acggcccata tttgtcacac tccatattta ataattccta taagtatact 2449441 atggattaat gatggaacag ttcctataat accacatatt ctgaaaagca ggtactaaaa 2449501 cactttgtgt attttatgcc atctcatatt gcgcattgac cgcaaaaaag cttatacttc 2449561 atatgacttg tgaaagctgg agggtcaaga catgaatttt caattagatc tgattaaaga 2449621 caaagtggaa ttttttgaag cggcttcatt gcaggagctt gaaaagaaaa tcaatacaca 2449681 aattgaaaac aataaagcca tcatgctccg ggtgaaatct gtttcacacc aaactcttgt 2449741 ggcagaagga agaatattgt acagcgcggt ggttcatttc tcagctgaag cctaaaacaa 2449801 aagcagccgg ttttaacccg gctgcttttg tttattttag cttttctact tttgtcggct 2449861 tccagccttt ttcatcgacc catgtaatcg tgacttgata tttattccca gtcgccttgt 2449921 ccaaaatctt gcctttggca tcctgagggc tgccgttatt tccaagccag agcaccgtca 2449981 tgttatctgt tgagacacca gttgcgtacg aaatggcttt cagcatctca gcccagtctt 2450041 gtgagcttga atcataagta gcggcatgct cgccagtctg ctcagttccg actgctttcc 2450101 agtcaggatt ttcatacgtt ttttccacat cgctcgatga gccgccttct gttacttttg 2450161 catctttaag cccgtcaccg gctgaatctg agcttgaatc tgaatcagag tcatcttttt 2450221 tagaagaaga atcatctttt ttggaatcag agtcagaaga cttctcagaa tccttttcgc 2450281 tgtcagatgt atctttcttg ctgtctttta tatcctcatc cgatttcttt tccgtctttc 2450341 ctgaagccgg agattcctgt ttttgcgccg tttcagaatc cttgctgaca tctttgctag 2450401 aaggactgtt aatgaagaga ttcgctgcta ctacgacaat tagtatggat acgattgcga 2450461 ttaaaatgtt aagcactaaa ttggcttttc tgcgtttatc acgattttca taacgagatt 2450521 gattattgct caataattct gcactccttt atccctcttg gctcagcata tattttaaca 2450581 tgtgctgaga agttgttcta tttctgattg atttcaattt cgtgtacttt tttaacaata 2450641 tcataaaaca ccgaatttgt cagagcctta tctcccggtg tatccatgtg taaaacaact 2450701 agagcgtatt tcggcttatc cgcgggaaaa tatccggcaa accatttttc gtagagcgtt 2450761 tccttctctt ttgaaagctt gcctgtctgg gctgtgcccg acttccctgc tacagtatac 2450821 ggaagatctt gaaaccttct gcccgttccg gaaggagatt ctactacccg ccgcagtatt 2450881 ttttgaagct gctgtgacgt atatttgtct atcgtttccc ctttgagctt ctgatcttta 2450941 aacgtaacga gcgttgtgcc gttcttatac tcaatttgtt cggcaatttt cacctgccgt 2451001 ttttctccgc cgcgggcgat tgtcgccatc atattggcta cctccagcgg cgttaccttt 2451061 acatttttct gcccgattgc tgtttgcgca atggcttttt tgactgattt gtctttttca 2451121 tccccccaaa tcacgccgct tttttcgtta tacagctggc ggaaatcggt ttcgtggtac 2451181 agttttccct cccagcctgc ccgatcagtg agagccagct tctcggacat atcttcaata 2451241 accgagctgt cttttttcat taattgttct gcaagactcg taaatgtgta attacagctt 2451301 tgggcaaaac tttcatcaaa agacaaggtg cctttgtcgt cccccggttc cccgtacagg 2451361 tttaaattgc aattaaaggt ttgactaggc ttcaccatat tattttcgat tgcagctgcg 2451421 gcaatgactg ttttaaaaac tgatccggga tagattggcg tcagcatata attttgaagt 2451481 gtgttttgcc gggacacgtc tgcatctggt ttgcttacaa ttcccagaac actgctattt 2451541 tcgatgtcca gcagcacagc tcctcccttt ttcagcccct gttcatccaa tacctcctcc 2451601 atcgcttttt gaatgctttg atcgatcgtt gttttgatct ggagcggata aaatgtattg 2451661 gcttcagctg tatatttgac gtccatgcca aacaaagggt ttccttttcc gtccacatga 2451721 tataaaagct ttgtgtcttg ttccggaagc aaaaactcgt caaatgtccg ttctaaaccg 2451781 gttgttccga tttctgttgt aatcggaagg ctctccttgt caggatattt cttgcgaagc 2451841 agcgccggat cttggttcgt gctccctatc gtatgtgaag caaggctggg cttgtcttca 2451901 ttctccatat atacgccgta aatgccggga tatttcaaag aattgatttt tgtgatagat 2451961 tgttttgaaa gtgttttgat tttcttttgc tgcaaaatga ccggtttttt tgcctgacct 2452021 agtgtctggc gcaaatcatc ttcagacatg ccgaggatgt ccgcaacttt tttgatcggc 2452081 caatcctgcg tcagcagaaa agggaacaaa acaaccgcag gctcgctttg tcctgtcagc 2452141 gcccgcccgt ttcgatctaa aaaagagcct cttccatctg aaatgagcac ttcctccgtc 2452201 cgctgtttca cactttcttg aatcaaatta attttctttt tagaaaatga ttctgtgaaa 2452261 aacagctgga tttctgcaag tctcagcaga agcagaaaaa atacaatcaa aaaagcgatg 2452321 actgccagct tcattcgttt cgatatcttc ataaaaaaac acctcaccca cattgtggac 2452381 gaggtgtttc gctgctaaac agatattatg aaattttcac aattttcacg agcatttctc 2452441 cgcccggtgt ttgtactgtg acttcttcat ctactttttt gcccaagagg ctttttgcga 2452501 tcggtgaatc gtttgagatt ttcccttcaa acgggtcagc ttccgcgctt ccgacgatcg 2452561 tatatgattc ttcatcaccg tcaggcagtt cgacgaaagt gacggtttta cccaaaccga 2452621 caacgttaga gccgccgtca tcttcaatga ttttcgcatt gcgaatcata ttttcaagag 2452681 tcgtcacgcg gccctctaca aatgcctgct cttctttcgc tgaatcgtat tcagagttct 2452741 cggaaaggtc tccgaagctt ctcgcaattt tgattcgctc tactacttct tttcgtttaa 2452801 ccgttttcaa atattctaat tcttgttcaa gtttttgttt tccttctgca gtcataggaa 2452861 aaactttctc ttgtgccatg tcccttcact ccttctggtt gtccctcaac atcttcgatt 2452921 atgtatgaga gcataaacta aaaaatacaa gaatgagaac acagggcagt cctcgttctt 2452981 ctctcccata taggtactgt ttatcttaaa ctgaatcgtg tcgttctgca aatatttcgc 2453041 gtttataaac agggaaagaa gggaattcgc acattccctt cctgcctata cataatatgg 2453101 tcagagttat ttatgtctat gctatggtat tacaaaatcg cgttttgttc aagaatggtt 2453161 tgaatttttg tgaccatcag atcaattgcg acgtgattct gaccgccttc cgggataata 2453221 atatcagcgt atcgtttcgt cggctcgacg aattggttat gcatcggacg gaccactgac 2453281 acatattgtt caatgacaga atcaatagag cgtccgcgct cattaatatc tctcataatc 2453341 cgtctgatga tacgcaagtc agcgtccgta tcaacataaa gcttgatatc catcagatca 2453401 cgaagccttt tgtcttcaag aacaagaatg ccttcaagga taataacatc ctttggctct 2453461 acgtgaaccg tttcttctga acgtgtgtga agcttatagt cataaatcgg cttttcaatc 2453521 gggcggtaat tcaatagatc ttgaatatgc tcgattaaat agtcattatc aaacgcaagc 2453581 ggatgatcat agtttgtgtt cagcctttct tcaaacggaa gatggctttg gtctttataa 2453641 taaaggtcct gctggatcat taaaattgag tgtcctttaa actgttcata aatggaccgt 2453701 gtgacactcg tttttcctga accggaacct cctgcgattc caatgactac tggattctta 2453761 cccatgggct gttacttccc ctttctcatc atgttgctcg gataaatctt tttgtctagt 2453821 ttgaatttga caatttgcag gggatggcgg gcagcatcta gctcatttcc gtcttcgtcc 2453881 caaatggttt caatcgtatg tgtaaagttt tcgatttctg gaccgaaaaa ttccacttcg 2453941 tcgccttttt tgaagaaatt gcgctgctga agcgtgacca tttgtgtatc ttcatcataa 2454001 ttcagcacta agccgacaaa atcatatgtc gttttcttgg cgtgttcgcc gaacatttgc 2454061 tcttcatagc ctggcgttcc ttcaaagaaa gctgtcgcag tgtccctgtt ggcgcactta 2454121 tcaagctctt caagccattc tttttgaatc acaaagtttt ctggatcagc gcaataagca 2454181 tcgattactt tgcggtatac gctgacaaca gttgctacat agtgaatgga tttcatgcgg 2454241 ccttcaatct ttaagctgtc gatccccatt tcaatcattt ttggaatgga ttcaatcagc 2454301 ttcaaatctt tcgggctcat cgcaaatggt gcatcttctt caccatacaa agcaacggcg 2454361 ttggcaccgt ctgtttggta gagatcataa tcccagcggc atgactggca gcagcctccg 2454421 cggttggaat cccgcgctgt catgtgattg ctcagcacgc agcggccgga atatgcaata 2454481 cacattgcgc catgaatgaa ggattcgatt tcgatatcta ccttttcttt catttctctg 2454541 atttcaagag cgctagtttc acgtgccagc acgacgcggt cgagaccttc ttccttccag 2454601 aactggacag ccttccagtt tgaaagagac tgctgtgtgc tcaagtgaac ctcaacattc 2454661 ggcgccactc tgcggcatgt ttcaataata agcggatctg ccacaataat accggcaacg 2454721 ttggcgtctc caagcgcttt taaatagtct tcaagcccgt ccatgttttc attatgagcg 2454781 aaaatattcg ttgttacgta gatcttcgcg ccatatttct ttgcgaattc aacgccttct 2454841 gcaatttctt cgatcgtaaa gttatcggca ttcgagcgaa gcccgtattc ctgtcccccg 2454901 ataaagaccg cgtccgctcc gtaatgaaca gcgattttca gcttttcaag attacccgca 2454961 ggtgcgagaa gctccggctt tttcgtaatc acacgctttc cattaacgat tgtggatatt 2455021 ttatcattta cggcagtcat agcttaacct ccttttgatt aataaaccgt ttccttgaag 2455081 aagaatccgg tatcaatttt tctgtttact ggctggatgc tttcaatgcg ttcgatccag 2455141 tcttcttttt tcgcttcgta ttcgtcacgg ttttccacgc acaaatcaat tgcttctctg 2455201 tacattttgg tgacttctat taggtattca ggcattttca aaacaccatc gattttgaaa 2455261 gaatcaattc cggcatctat caattcctcg agctcatcaa tgatgcacac atcgttcggg 2455321 ctcatgatgt gagtgccgtt ttcatcttcg aaaatcggat atttattatc gcgttcttta 2455381 tcgtgtaaaa acatgcctga ttcttttttc tttctttcaa tgtccatgac tttgccctga 2455441 tattcaaaat agtttccaat caaagaacgc ttcgattgga acatgcacgt cattccatgc 2455501 acctggattt caatttcgac ttcagcattt tctttaatct caacaatgct gtccatgttt 2455561 aattctctgg caagcacaga acgcgccgca cccttgcgtc cccagtagtt gcatgtataa 2455621 tagttggtgc ctgtcgtttc tgtgctccaa tgaagcttca gatcaggcgc agattcacgg 2455681 gcagccatca gcacggcagg atcgccgaat accgctgcat cgacaccggc ttctgctaag 2455741 aaagccagat attcgccaag ctcacccact ttatcattat ggaaaattgc atttacagca 2455801 acgtatactt ttgccccttc tttgtgagca atctctacgg cttttgttac atcttcacga 2455861 gaaaattctc cggctaatct caagccgtat ctctgttccc caactaaaaa cgcagttgcc 2455921 ccagcctgta tgagcggcaa aatgtccgct gtactcgtcg gcgtcactaa gagctctggt 2455981 tttttcatga cgttcacctc ttctttttac taatcgcaag tccgtccccg acaggaataa 2456041 tcgcagtttg ataatccgga tgattcatca gccaatgatt atattcatca attttggcta 2456101 caagcctgcg ccttctcttc ggttctattt tgctgtaatc ctctgccacc agacctttaa 2456161 acagcacgtt gtctgttata atcaccccgt ccggtgaaag catcggttca tataaatgaa 2456221 aaaagttttg atactgacct tttgcagcgt caataaaaat gacatcgtaa ggcgcggtta 2456281 catgaacggc gtcggctaat tcaagcgcat ctccgtaaaa aacatgaatc cggtcatcaa 2456341 gctgaaattc cttgatattg tttaccgctt cttcatgccg tttctcattg cgttcaattg 2456401 tatatatttc agcagacggc agttccagag ccattcgaat ggctgaataa ccaatggccg 2456461 ttccgatttc tagtattttt ttcggctgtt tcacagacaa aatttgaagc agcacctcca 2456521 tgcccgcttt ttccataatc gggacatgat gttcttctgc atatgcttca agtctcttca 2456581 cgttatccgg ccgaggcttt aataatgctt ctatatagtc atttatttgt tcataccggt 2456641 cagtcactac aaacagcctc ccgttctaaa aaggagtgcc ccagtcttat gcgcaggaca 2456701 ctctctgaat acatcatgat acatcggtaa acaacccgat atattttatc ataaaacctt 2456761 gcggaaagcg aacaaaagga gagctttttg ctctcctttt atttctcatt ttttgaggaa 2456821 atgtattttt cttttgcttt attatgctct tttagcgttt ttgtaaatac gacctcacca 2456881 tttgatttgg ccaagaaata cagatagtcc gttttatccg gatgcagcgc tgcttcccat 2456941 gatgacatgc cggcattggc aatcggccct ggcgtcagcc ctgtgttttt atacgtattg 2457001 tatggtgaat cgatttccag atccttataa agaacccgat ctttatgctt gcctgccgcg 2457061 tacaggacgg tcggatctgt ttggagcggc attttctttt tcaggcggtt ataaaagacg 2457121 ctcgcaattt tatggcggtc ggctttttca gtcgcttctt cttctatcaa agaagccatt 2457181 gtcagcagct tatgcacaga aactttgttt ttcttcattt ctgatttata tgtttccaca 2457241 taagaatttg tctgcttaat cattgccttg ataatgtctt caagtgatgt gtccggatcg 2457301 ttaaaagggt atgtagccgg gaataggtac ccttcaagcg ggtgcttaat gtttttattg 2457361 aaaacatcat ttgtcacagt gtccgggaat tctttcttca gctgattgat aaatgtttca 2457421 tcgtccagct tcgctatgac ttgtttttta gagtattttg tttcatcagc aatagcagcc 2457481 gcgatttggg tcagctgtgc tccctcagtc actgtgattt gaaaagcgta acctgtagcc 2457541 ccgcttgtca gcttctgaat aatggcatct aaatccatac ctttattcag atggtagaat 2457601 ccggcctgaa acccggaagc acctttatat ttcacatagt actgaaacgc cttctcgctt 2457661 tttatgacat catttttctt taatatcgat gcgatggctg aaacagacga accgctcgga 2457721 atgttaatat taactgtcgt tttactgtct ttttcaacag gttcaagcaa tgatttccca 2457781 tataaaaatg ccccgccaat gatgagaaac agcacaacaa tggaagacag tatgattctt 2457841 tttttattaa aaaacgattt tttttgctga ttgatataca ttaggtctcc tcccatcagc 2457901 tcttatacta catgattcat tgtatttcgg caatttatta caaaaagagg cctgcataaa 2457961 gcagaaaaaa gccggagcag tatagctccg gctttggttt ggcgcgatgt tttactcttc 2458021 gtcttcgtcc gctaagaatg tgtttagtgt ttcttcgatc atatcccatt cttcgtcagt 2458081 ttcaatcggg aatagctcac cgttttcacc gtcttcgttt ggcgtgaagc tggaagcaag 2458141 aatttctact tcttcgtcat cttttgattc gattggatag tacaagacat aagatttgcc 2458201 aaactcttca ttttcaaatg taaacagcac ttcacaaagc tgttcatttc cttgatcgtc 2458261 aacaattgta atattttttt cgccgtgttc cattttcttc acctctggct ttaatttaag 2458321 ctgtcaagat atccttgtaa aatcataaca gccgccattt tatcaatgac tttttttcgt 2458381 ttttgcctgc tgacgtcagc tgcaatcagc attttttcag ccgccattgt ggtaagacgc 2458441 tcgtcccaca gcacaacagg aacattgtac gttgtttcaa gcactttcgc aaatgtttgg 2458501 ctggcttcgc ctctcgggcc gactgttccg ttcatgttct taggaaagcc gagcacgatt 2458561 ttatctatag tatagtcctt tatcagttca gataaacggg ataaaccata atcgccttct 2458621 gcttcattta tctttatggt ctcaatgcct tgagcagtcc agcccatttc atcgctcaga 2458681 gctacaccga gtgttttggt tcctaaatcg agtcctaata ttctcattct ttatttacgc 2458741 ctctttatgc tgttctaaat aagactttac caattcctcg attaattcgt ctctttcaag 2458801 tttgcgaatt aaattgcgag cgtcacgatg cctaggaata taagcgggat cacctgacag 2458861 caagtatccg acaatctggt tgattggatt gtagcccttt tcctgaagcg cgtcatacac 2458921 tgtaatcagc acctcattta cgttagtctc agcagaatca tcggagaaat taaatttcat 2458981 cgttttatca aacgagctca ccgttttgca cctctttccc aaattcgcag gcaaagttca 2459041 gcctggggtc ctaatcttac catcattcta cactacatgg gcgaattata aaacggattt 2459101 cacccaatct tctacagaag ccaaagcttc ttctaatttt tccggctgtt taccgcctgc 2459161 ctgcgccatg tccggacggc ctccgccgcc tccgccgcaa acttccgcag cttgtttaac 2459221 cagcttgccg gcgtgaagtc ctttctcaat gaggtccttt gtgactccgg cagagatatt 2459281 aactttatcg ttttgtaccg caccaagcac gatcaccgca gagccaagct ttgctttgag 2459341 ttcatcgacc atagtgcgga gatgattcat gtcttttgca tttacttttg ccgcaagcac 2459401 gtttacgccg tcaacttctt ttactttcga caggattgct cctgcttcca cgttgcctag 2459461 ttttgcaaga agagattcat tttctctttg tgcatccttc agttcagcct gcagagccgc 2459521 gacccgtttc ggcacttctt tgatatttgt tttcagctcg tcagcggtct gcttcaatac 2459581 agaaatctgg ctgttcattt cgacgtaagc gccttgtccc gttacagctt caatccgtct 2459641 tgtgcctgct ccgattccgg attcagaaac gattttaaac aagccgattt ctgctgtatt 2459701 tctgacgtgg cagccgccgc acagctctaa gctgtaatct ccaacttgaa cgacacggac 2459761 aatatcgcca tatttttcgc cgaacagtgc catcgcaccc atttcttttg cttcagcgat 2459821 cggtttcaaa tcaatgctga ccgggatgct cgcccagatc ttttcgttta cgattctttc 2459881 aatttgttcg agctcttctt ttgtcacttg gccaaagtgc gagaagtcaa aacgaaggcg 2459941 gttttccgtt acaagagagc ccgcctgatt gacatgagtt ccaagaacat cttttagagc 2460001 ctgatgcaat aaatgcgttg ccgtgtggtt tttaatgacg ccgcttctca tatggtcttc 2460061 aacttcagcc gtaacatgca ggcctttttg aacagtaccg ctctccacaa caccttcatg 2460121 cacatgctgg ccgttcggcg ctttttgaac atctttaatt cttacaactg cctgctcgct 2460181 tcggagatag cctttgtcgc cgatttggcc gccgctttct gcatagaacg gtgtttcatc 2460241 aagaatgatt tgaacgcttt ctccttcatg agcctcttcg attaattggc cgtcctgaag 2460301 aagcacaatg atattggcat cagctttggt ttgagagtag ccgacaaatg tgctttcaac 2460361 tgtcacgtcg cgcagtgcgc cgccctgcac ctgcatgctg ccgacatcct ggcgggcgtt 2460421 tcttgcccgt tcacgctgct ggttcatttc ctcctcaaag ccctcatggt caaccgtcat 2460481 gttctcgtct tctgcgtatt cttcagtcaa ttcaaccggg aatccatacg tatcatacag 2460541 tttaaacaca tcagcacctg agataacgct gctgcccttg tctttttctt ttttgatcat 2460601 ttctgacagg atcgcaagcc cttcattaag ggtctcatgg aagcgttctt cctcggtttt 2460661 aatgactttt gcgatgaaat ccgctttctc tttcacttca ggatagaaat cagccatgat 2460721 ttctgcgaca accggcacta aatcaaacat gaacggacga tggatgttga tcgttttggc 2460781 ataacgcacg gcacggcgta ataagcgtct taatacatag ccgcggcctt catttgacgg 2460841 cagcgcaccg tcactgacag caaaggcaac cgttctgata tggtcagcaa tcactttaaa 2460901 cgcagtgtct ttcacattgt ctttgccata tgtttcacca gaaatcgatt ctgttgcttt 2460961 aatgatcgga acaaacaaat cggtgtcaaa gtttgtcgga acattctgga tgacagacac 2461021 cattctttca agacccatgc ctgtatcaat atttttcttt ggaagcggtg tgtacgtgcc 2461081 gtcagggtta tggttgaact ctgagaacac aaggttccat acttccaggt aacggtcgtt 2461141 ttccccgcct gggtaaagct ccggatcttc tggatcatta ccgtatgctt caccgcggtc 2461201 gtaaaagatt tccgtattcg gtccgctcgg cccttcaccg atatcccaga agttcccttc 2461261 cagacggata attctttctt caggaatacc gatttttttc gcccaaaact catatgcctc 2461321 ttcatcttca ggatgaaccg taacagagag aagctctttg tcgaagccaa tccacttgtc 2461381 gctcgttaaa aactcccaag cccatgtaat ggcttcttct ttgaaataat cgccgatgga 2461441 aaagtttccg agcatttcaa agaaagtgtg atggcgcgca gttttaccta cattttctat 2461501 atcgtttgtt ctgatcgctt tttgagcgtt tacgattctt ggattttccg gcacgacacg 2461561 gccgtcaaaa tattttttca gcgtcgcaac accgctgttg atccaaagca gtgaaggatc 2461621 ctcatgaggc actaatgacg cgcttggctc taccgcatgt cctttttctt taaagaaatc 2461681 caaaaacatt tgacgcactt ccgcagaagt taagtgtttc attgtatttc ctcctctata 2461741 aaaatcgaaa ttctcttcag tgacagcaaa aaagccctcc ccctatgcaa accaacgttt 2461801 acacagggac gagagctgtc tcgcggtacc accctgatta cgggcattca tgcgcccgtc 2461861 acctttaacc ctgtaacgca ggataagcgg cagtgattaa ctgcactcag gattagcttc 2461921 ctccgatctt ctgataaagc tcctttcagc ttatggagct tctctcttta acagggcttc 2461981 ggcgtactca gatccgtcac tcgagattcg tatgtattct acgagaaatt atagacaagc 2462041 ggcacgccga tgtcaatgct ccgtcctcat ccgcaaaaaa tggatcatca ttacttttaa 2462101 aacagccgtc gcaggaacag ccagaatcat cccgacgata cccgcaagct cccctccggc 2462161 aaggagtgca agcatgataa cgaccggatg cattttaagg cttctgccga caatgaacgg 2462221 actgaggata tttccttcca taaactgcag aataaacacc gtaatcacca caacaagaac 2462281 cgccttgact gagatcgtca tcgcaattaa caacgcagga acagctccga tgaaagggcc 2462341 aaaatacggg atgacattcg ttaccccaga gataaggcca agtatcagcg gatacggaag 2462401 cccaaatacc cagaacgaaa tgcctgcaat cacgccaaga atcaagcaga ccaaaagctg 2462461 gccgcggata taatcgccaa gcgaatcatc cacatcccgc aaaaaggcgc tgccccgctt 2462521 tctccacgac ttcggagtca agtaccatac tgtctttttc attaactcaa tgtccttcac 2462581 catataaaac acgagaaaag ggattgttgc agcaattaag aagtaatcaa gcacattgcg 2462641 gatcccgctg atcgcaccct cgatcgttcc cgcaaaaaac gcctccgtct ggcggatcat 2462701 tttatctata cggtgatgca taccatcagg ccagtcatcc gtatggttat gcacatgaag 2462761 aagaagcccg ttatacgttt cggcaaacat gggtatattt tctgacaaat ccgtcagctg 2462821 cacgattaaa acaggcaccc ctttatacaa cgcccagcca atcccgccaa aaaaaagaac 2462881 ataaatgacc aagatgctca aagtcctagg caatcctttg ccatgcagcc attctgtgac 2462941 cggaagcaat aaataagata taaaaataga aatgatcaag ggaataaaga tcgtttttat 2463001 gacgagccaa aagggtgacc ataacatatc aagcataaaa aagacataga ctgttaacag 2463061 aaccagcaaa caaatagcca cccacaacaa aagctgcacc ggtttttgga gcatctgctt 2463121 tcacctcacc tatatctttt gaggtttaca aggaattatt ctttatgttt ctttagtcag 2463181 tcagaagtca tggacatttt ttcactttta attttcagaa aagtttgatc atttactttt 2463241 tggtcaaatt ttctgatagg aggattgcga tgatcacatt tcaaaatgta aacaagcatt 2463301 acggagattt tcacgtgtta aaacaaatta atcttcaaat cgaaaaaggt gaagtcgttg 2463361 ttatcatcgg cccatccggt tccggtaaaa gcacattgct cagatgcatc aacagacttg 2463421 agtcgatcaa tgagggagtg cttacagtaa acggcaccgc cattaacgac agaaaaactg 2463481 atatcaatca agtgcggcaa aatatcggga tggtgtttca gcactttcat ttatatccgc 2463541 ataaaacagt gctgcagaac atcatgctgg ctccggtaaa agtgcttaga caatcacctg 2463601 aacaagcaaa ggaaacggcg cggtactatc ttgaaaaagt cggcatccca gacaaggctg 2463661 acgcctatcc ttcccagctt tccggcgggc agcagcagcg tgttgccatc gcaagaggac 2463721 tggcgatgaa gccggaggtc atgctgtttg acgagccgac atcagcactt gatcctgaaa 2463781 tgatcggtga ggtgctagat gtcatgaaaa cactcgccaa agaaggcatg acaatggttg 2463841 tcgtgacaca cgaaatgggg tttgccaaag aagttgccga ccggattgtc ttcattgacg 2463901 aaggaaaaat tttagaagaa gcagtgccgg ctgaatttta cgcgaacccg aaggaagaac 2463961 gggcccgctt attcttaagc cgtattttaa atcattaaaa cagaaatggg ggagcttgta 2464021 tgaaaaagat tttttcttta gcattgattt ctttattcgc tgtcatcttg cttgccgctt 2464081 gcggcagcaa gggatcaaac ggagaagcct caaaggagag caaaaaagat acgctagccg 2464141 ccattaaaga caatgacaaa attgtcttcg gcgtaaaaac ggacactcga ctgttcggtc 2464201 ttaaaaatcc aagctcaggt gagattgagg gttttgatat tgatattgct aaacaaatcg 2464261 ctaaagacat tttaggtgat gagaaaaaag ctcaatttaa agaggtcacc tcaaaaacaa 2464321 ggattcctat gctgcaaaac ggggatatcg acgccattgt cgccacaatg acgatcactg 2464381 aagaacgaaa aaaggaagtt gacttttctg atgtctattt cgaggccggg caatcgcttc 2464441 tcgtgaaaaa aggcagcaaa atcaagagtg tcgagaatct tggcaaaggc tcaaaagttc 2464501 ttgcagtaaa aggctccacc tcctctcaaa acattcgtga aaaggcgcct gaagcatctg 2464561 ttttagaatt tgaaaactac gcagaagcct ttacagccct taaatcgggg caaggcgatg 2464621 ccctcaccac agataatgca attttatatg gaatggctga tgaaaataaa aattatcaat 2464681 taacaggaaa gccttttaca gatgagcctt acgggatcgc cgtgaaaaaa gggcaatctg 2464741 ctctcgcgaa agaaatcaac gcttcactta aaaagatgaa gtcggatggc agatacgatg 2464801 aaatttataa aaaatggatc aaagaagacc cagctgaata acaaccatcc cgggatgagc 2464861 aggcgatgct catcccaatt tgataaggag tgaataggca gatgaatgtg tcaattcttt 2464921 tcgataactt cagcatgtat atggacggtt tttaccatac cttgctcgca agtgttatcg 2464981 cgctggccgg cagttttgtc ctcggcgttg ctgtagcggt tatgagaata acagtcttta 2465041 agccgctgca atggctcggg accgcatatg tagaattcat ccgcaacatc cctcttcttt 2465101 taattacctt tgttttctat ttcggacttc caaacgcagg cctgaggctt gacggttttc 2465161 aagcgggaac ggttgctctc accatttata cctctgcgtt tatcgctgaa gccatcagag 2465221 caggcatcca gtctgtttca aaagggcaga tggaagcggc acgctcgtca ggctttacct 2465281 acagccaagc catgctccat atcattttgc cgcaggcaat caaaatcgtc attccgcctt 2465341 taggcaatca atttttaaac ttagtcaaaa actcttcgat tcttggggtt gtggccggat 2465401 tggatcttat gtaccaagcc gatttagttt cgtcgagcac actcgttgta tttgatgttt 2465461 atatttttgt ggcgcttttt tacttagtgc tgacgattcc gcttagcatc ggtgttaact 2465521 atctggaaaa acggctggaa aaaagctatt gataaggagt gagttacatt ggatttcatc 2465581 ggtgcttatt cacaggagca tttagcgttt ttatgggatg gctttctcgt caccttgtac 2465641 gttgctttca tctccatcat tctgagcttt ttcttcggtt taatcgcagg caccctgcgt 2465701 tatgcgaaag ttcccgttct ttctcaattg attgcagttc tcgttgaaac gatcagaaac 2465761 ctccccttgc tgttaattat tttctttacg ttttttgccc ttccggaaat tgggattaag 2465821 cttgaaatta cagctgctgc aattacagca ctaacgattt ttgaatccgc tatgctatct 2465881 gaaattatcc gaagcggact gaaatcaatt gacaaaggac aaattgaagc ggcgcgctcc 2465941 tccgggctga gctatacaca gaccctgttc tttatcgtta tgccgcaagc gcttcgccgc 2466001 atggttccgc ccatcgtaag ccagtttatt tctttattaa aagatacatc gctcgctgtt 2466061 gtgatcgccc tgcctgaact gattcacaac gcgcaaatta ttaacggcca aagcgctgac 2466121 ggcagttatt ttttcccgat ctttttactt gcggccctta tgtatttcgc agtcaactac 2466181 agcctttcac tcgcagcaag acgcctcgag gtccggcaaa catagaaaag gatactcttt 2466241 ggagagtatc ctttttgcat taaaacattt tcgtaattct tcttctcatc cgcttcatgc 2466301 ttcgattatt cagcatgtca gattgagtcg ccattcggta cacgagagct ccggctccca 2466361 ttgccaaaag agaagtcatc gtccgattca tcctgcgcat ctcctttcat gattaaaaat 2466421 tgatgctgcg ttcatcctca gaaaacaaat catccaagct gcttaacgtt ccgtcttctt 2466481 ccacctgatg agttgcaatc ttccctttcg ccactgtcag ttcaataaaa cagccccagc 2466541 aataatattg gttcacgccg attttgccga tatccttact tttgcaattc gggcatataa 2466601 gcatacctca cacctctatc cgttcagaac gatctcgtct ttccgcacct cgacaagcga 2466661 atccgctctt tggatctggc gcttgcttcc cgccaggtca gaaaagaaac cgtccgagag 2466721 ttcatatgct acgattatgc ccctgtccaa acaaaagtat acatcttcca gcatccccaa 2466781 tatatccccc tcttgcgatt tcacaagctt catcttcatc tgctcgtatg tgaagcatga 2466841 tttcggaaga ggcaaaagct gttctgaact gaccgaagcc aatatgcggt catcaaaaat 2466901 ggaagagata tcacacgccc gtaatagcgc atgatgatga tgcaaaaagc gtttttgtgc 2466961 aagaataaac ccaagacaat ctcctttcag agaaaaacaa atatcggaaa ttgtcccgag 2467021 ataactagaa gttcgttctg agtatactgg gaatccttct acttcatggc atgttctcaa 2467081 agtgtgatca accacctttt gttgaacagg cttaggtttt gctttgcgcc ttagactcat 2467141 acgatgaaat caattccact gcaaatgaaa aaaaactccc gcttgcacgg gagcatttta 2467201 ttgctgttct tctttcataa aatcgaatgg tgtaatgcct tccatgccaa tgttggcgtc 2467261 gtgtacgctg aacgggagct ctttttgcaa agcttcaagc tcggcatcca tttcctcaac 2467321 ctgtacggac agcctgtttt tcaaggaggt ctgtctgaca gttgcatcat tatttttcac 2467381 gccccactcc agcgcctcct cttccccgca taaaatgaga aatttcttcg ctcttgtaat 2467441 cgcggtataa agaaggtttc ttctgagcat tctataatag cctttcacaa caggcaaaac 2467501 cacaatcgga aattcacttc cctgcgattt atgaatagaa cagcaatacg catgggtaaa 2467561 ttgattaaaa tcttttttcg taaatgtcat ttcattgccg tcaaaagaaa cgacggccat 2467621 gtcttctttt tctgtatttt cctttgcata aaatatcgac gtgatttcgc caatatctcc 2467681 gttgaacaca ttgttttccg gctgattgac aagctgcaaa attttatctc cggttctgta 2467741 gacaacatcc ccgaacttca attctctccg tttttcttta ggaggattta aaatgtcctg 2467801 cagcatcaca ttcaattcat taatgccggc ttttcctctg tacatcggag cgaggacctg 2467861 aatgtccttt gctgtatagc cttttttcaa tgcattggcg acaaccttct caactacttc 2467921 tttgatttgc gacccgccgc agcgaataaa ggaacggtcc tttgtcgggg cagtcaaatt 2467981 gttcggcagc aatccatttt tcatctggtg ggcaagctcg acgattgatg acccttctgc 2468041 ctggcgatag atgtctgtca gtctcacagt cggaatcacc tgggatgcca gcaggtctct 2468101 gagcacttgt cccggaccga cggaaggcag ctggtcttcg tctccgacaa tgatgatttg 2468161 tatatgatca gggatcgcct tgaacaaatg attcgccagc catatatcaa gcatactggc 2468221 ttcatcgata attaacagct tcccttcgat cggctgatcc tctgtatgag taaagccttc 2468281 agcgccgttc cagccaagca gcctgtgtat cgtaactgca gggagtcccg ttgattcact 2468341 catccgtttt gctgctctcc ctgtcggagc ggccaaaaca atcggaaaag cttcatcctt 2468401 tttataagct gacgggtcta gtgacacacc gtgaagctct ccgtagagct cgacaatccc 2468461 tctgattacc gtcgtttttc ctgttcccgg gccgcctgtt aaaagaagca tcggcgagga 2468521 aagggctttt tgaatcgctt ccttctggct gggggcatac tgaacgtcca tccgttcttc 2468581 cagttctccc aacgcgagca aaaactctga ttcgggaaac tggttctcat attcggtttg 2468641 gctagcgata tgtttcacac gctttgcaac gttttgttct gcgtaaaaca gcgaaggaaa 2468701 ataacagcgg ccatcttcta tgacaatgtc tttattttct ccaagggcaa taattgcgtt 2468761 agcggcatcc atttctgtaa tgcgctgccc ttcccttgct gactggttta acagtgattg 2468821 agtgtcgatg atcagctgtt ccgtttctat gtacgtgtgc ccctctgaca gacaagtcgt 2468881 ttcaagcgtg tacaaaatag cagcttttac ccgctcagga tgattacccg aaagacccat 2468941 tctgctgccc agctcatccg cttttccaaa cccgatgcct tctacatcct tcacaagctg 2469001 ataaggattt tcctgaatct tttcaagcgt ctcggattca taggcttgat agattttcat 2469061 agacagctgc gggccaaagc caaactgatt caaggaaatc atgatttgct ccagtccctg 2469121 atgccgctgc aatgcgccag ccagcgtgtc tgctttcttt tttgagagtc tgggaacatc 2469181 ataaagcact gaagcatcag ccaatatttt attaatggcg ctgtcgccca gctttttcac 2469241 aatttcttca gctgtttttt tgccgatccc ctcgaataaa tcactcgata aatattgaat 2469301 gatgccttcc ttagtcgttg gaatctcctt tttgaaatgc tccgcctgaa attggagccc 2469361 gaattttgga tgggttacga tctttccgta aaacgtgtag gtctcttctt cttgaagcgc 2469421 agggaagtag cccgtcacgg atacggcttt atcttcaatg gcttcggagg tctctgtgac 2469481 tttcactttc agaaccgtat ataaattggt gtcattatga tagatgactg tgttgactgt 2469541 cccttttaaa tagggctctt cctccagttt aagctgatcc ggatgctgct gcacgagctg 2469601 tccctcctcc tgtgcctgtt atgatggatc aatcagtttt ttagcatgaa gcgcaagcat 2469661 atgatctggc tggatatcga ttgccttgtc cagcatttcc agcgcttttt ctcggttttc 2469721 tttataagca taagtgacac cggcattata aaatgcatct gcatgccccg ggtcttgctc 2469781 tgtcacagct gcgaattggc tgagcgcttc gtccagcatg ccctcgttgg ctaagcacat 2469841 cccgaattga aaacgcgctt ccgtatcgtt ttcattcagt tcgactgctc tttgtaaata 2469901 tggcagtgca agcttaggct gttcgagctt gacaagtacc gttccgagca tgtaaaacag 2469961 gtcgccgttt tccatccccg cacgtagcgc tttttcaaac atgtctttcg cttctttgta 2470021 catttctttt acaacataga catttcctgc tccataataa gcagtggctg cgctactgtc 2470081 taattcaagc gctttatcat aaaacgcaag cgcacgttcc agctcgttta cggatgaaag 2470141 aaggttggca aaattgatat acggaatcgc gtcttcttta ttttcttcaa tcgcttttgt 2470201 aaatgcctct gccgctttct cgtaatcgcc ttcctgcatc gcctctatac cgagttgatt 2470261 ataatccacc gatcatcttc ctttcattaa aaaaccccaa ctcagtgttg aggtttttca 2470321 tcttttatac gtaccacaat tttgttccgt ctttgtacac atcatcaatt gtcccgccgc 2470381 caaggcattc ttcgccgtca tagaagacaa cggcttgtcc cggcgttaca gcgcggactt 2470441 gttcatcaaa gatgacttcc gcttcacctt cgccagtcat gcgcactgtt actttatgat 2470501 cctcttggcg gtaacggaat ttagccgtgc aggaaatctc ttcgcccttc atgatatccg 2470561 aacgtaccca gctgatattt gttgctgtga ttttgtcgga atataaaagc gggttatgga 2470621 acccttgatc tacgtagagg atgttctttt caagatcttt gcctaccgca aaccacggct 2470681 cgccgcttcc gccgatgcca aggccgtgac gctgtccgat cgtatagtac atcaacccgt 2470741 cgtggcggcc ttttacttcg ccgtccatcg tcatcatatc gcccggctgt gcagggagat 2470801 attggctgag aaacgttttg aagttgcgtt cgccgataaa gcagatgcct gtactgtctt 2470861 ttttcgtcgc tgttgcaagt tctgcttctt tggcaatttc acgcacacgg cttttttgaa 2470921 gttcgccgat cgggaacatg actttgctca gcgtatcttc tgtcagctga ttcaggaagt 2470981 acgtttgatc cttgttttca tcaatgccgc gcagcattct gacttttccg ccgcttctgt 2471041 ctactcttgc atagtggcca gtcgctaaat agtcggcgcc aagtgacaat gcatgctcca 2471101 aaaaggcctt gaatttaatt tctttgttgc acaatacatc cgggtttggt gttctgcctg 2471161 ctttatattc atcaaggaag tattgaaata ccttctcata atattgcttt tcaaagttta 2471221 cggcataata cggaattccg atttggttgc agacgcggat cacatcttca taatcctctg 2471281 tcgccgtgca aaaaccgttt tcgtccgtat catcccagtt tttcataaag attccgatta 2471341 catcatagcc ctgttctttt aacagcaggg ccgccacaga tgagtctact ccgccggaca 2471401 tgccgacgac gactcttgta tcctccggcc gtttttccat ttcattcact ccaattacta 2471461 cgccgcctta ttatgtcagc cgtttgacaa cgtcggccac atgtttggca gcagttttca 2471521 cttgctcagc cgtattgccg aggccgaagc tgattcgaat agaggacgtc agccggtcac 2471581 tctcttcgcc gaacatagca gtcagaacat gtgacggcag gactgaaccg gccgtgcacg 2471641 ctgaaccgct ggagacagcg acaccagcca tatcaagatt aaccagcagc gcttccactg 2471701 acacaccggg gaaataaaga ttcagaacat gcggcagact atgctctttg tccccgttga 2471761 cctcgaatgc cacacctgca tctctaagcg tgtcggcaaa gattgcttta aacgattgat 2471821 acttctcgtt tttttcgtca cgttcttcac ttgacagctt gatcgcttct ttcagcccga 2471881 caatgcctgg aacattttcc gttccggcac ggcgttttct ttcttgctct cctccgaata 2471941 aaaggggtga aagcttcaca tctttactag catataaaaa gcctgtccct tttggcccgt 2472001 tgagcttgtg cccggaaaca gacagaaggt caatatggct gtttttcaca tcaattggca 2472061 gcaacccgaa tgcctgaaca gcatcggtat gaaaataagc tttgtgttcc tttaacagct 2472121 caccgatttc ttcgatcggc tgcactgttc cgacttcatt atttccatac atcactgtca 2472181 caaggattgt atcatcacgc agtgcttctt tcacctgttt tgcactgact cttccatttt 2472241 ggtcaacgtc cagatacgtt atgtcaaatc cgtctccctc aagtttttca catgtgtgaa 2472301 gcacggcgtg atgctcaatt tttgttgtga tgatatgtct gccaagatct tttcttgcaa 2472361 gtgcggttcc catgatcgcc aagttatcag cttccgttcc cccgcttgta aaaatgatct 2472421 cctgctctgc cgctccgatt tctgctgcga tctgcgctct tgcttcatcc acccattttc 2472481 gagattctct gccaaatgaa tgaatactgg agggattacc gaaactgccg gagaagtgcg 2472541 gtatcatttg ttccagcacg cgctcatcca tcggagacgt tgcggcatga tctaaataaa 2472601 tccgttccat tatgtttaca cctctgatct aaatatagaa catataagct tcttgctctc 2472661 cgtctgtata gctggcaaga tcctctaatg ttgtactgtc taaaacctct tttacagcat 2472721 cccggatgcg aatccagagc tcacgcttgg caggctcctc atcttccagc acttcaacag 2472781 ggctgatcgg cccctcaagc acacggataa tatctcccgc agtaatggca tccggctcac 2472841 tgcctaatac atatccgcca tatgcgcctc tgatgctttt cactaaaccg gcatttctga 2472901 gcggcgatac cagctgctcc aaataatgct cggacaaatt attcgtctgt gcgatgcttt 2472961 ttaatgaagt cgggccttca ccgtgctttt ttgcaagctc gatcataatg gtgagcccgt 2473021 atcttccctt agttgatatt ttcaacatga acacctctgt tatttcatga ttttccacat 2473081 ttataatggt aatttctata tgtttcgtcc gtttattatc ttatagacca actgttatta 2473141 taacatacct tcagcgaatt ttcattgagg cagaaggaaa ggggccttta cccttttcta 2473201 atgtacggtt ttccgttacc ctgtaattaa gtaaggagag atgatagatg aagccattgg 2473261 catatcggat gcgtccgaca aaaatagagg atattatcgg ccagcagcat ctggtggctg 2473321 aagataaaat tattggcaga atggtccagg caaaacattt gtcatccatg attttgtacg 2473381 ggccgcccgg aattggaaaa acatcaatcg caacagcaat cgccggttca acaagtattg 2473441 cttttcgaaa gctgaatgct gtcattaaca ataaaaaaga tatggaaatc gtagctcagg 2473501 aagccaagat gtccggccaa gtgattttga ttctggatga agtccacagg ctggataaag 2473561 gaaaacagga ttttctatta ccctatttag aaaacggaat gatcattttg atcggagcaa 2473621 cgacggctaa cccgtatcat gccattaatc cggcgatcag aagccggacc cagatttttg 2473681 agcttgaacc gttaacacct gaactgatta aacaggcact ggaacgtgcg ctccatgatg 2473741 agcatcgggg ccttggcacc tattctgtat ccattgatga tcaggcgatg gagcattttg 2473801 cccacggatg cggaggagat gtccgctccg ctttaaatgc gcttgagctt gccgtgttgt 2473861 caacgaagga gtcagcagac ggtgaaattc acattacatt agaaaccgcg gaagaatgct 2473921 tgcagaaaaa aagcttttct cacgataaag atggtgacgc gcattatgat gtactgtccg 2473981 cttttcaaaa atcaatccgc ggctctgatg ccaacgctgc tcttcactat ttggctagat 2474041 taattgaagc cggtgatctg gagagcatcg caagacgatt gcttgttatc gcctatgagg 2474101 atatcggttt agcaagcccg caagccggcc ctagagtgct gaacgctatt cagaccgctg 2474161 agcgagtcgg gtttcctgaa gcgcgaatcc cgctggccaa cgcagttatt gagctttgcc 2474221 tctcaccgaa atcaaactct gccattctgg caatcgatga ggccctggca gatatcagag 2474281 ccggaaaaat tggggatgtc ccgaagcatt taaaagacgc gcattataaa ggagctcagg 2474341 aattaggaag aggaatcgac tataaatacc cgcacaatta cgacaacggt tgggtcgaac 2474401 aacaatacct ccctgatcct ctgaaaaata agcaatacta taagccgaaa cagactggaa 2474461 agttcgaatc tgccttaaag caggtgtacg ataaattaat gaaaagaaaa taaaacaaaa 2474521 aaacagcctt gatcatcaag gctgttttta tgcattattt atccttcaca cgtttgattt 2474581 caatgtcttt caaaagatcc atgacaacat gtccgcccat aatcaaacct gcaactgacg 2474641 gcacaaaagc attagaggaa ggcggcattt ttgctttacg tattttcgct tcgtcattcc 2474701 ccacttcttt tctgacatct tcccgaataa caatcgggct ttcatcagag aaaatcactt 2474761 gaacgccttt tttgataccc tccttgcgta atttcgtacg aacgaccttc gcaattggat 2474821 cagtgtgcgt ttttgagata tcagcgattt ggaagcgtgt cggatccgtt ttatttgcag 2474881 cacccatgct ggagatgagc ggaatatccc gttttagaca ttctttcatt aaatgaattt 2474941 tataacaaat ggtgtctgac gcatcaatga catagtcaag accatagtca aaaaactgct 2475001 catacgtttc ctccgtatag aacattttta acgcgatcac ttcacactcc gggttaatgt 2475061 ctgcgatccg cgccttcatt aaatcaactt tcggctgtcc gacagttgaa agcagcgcgt 2475121 gaagctgacg atttacattt gtaatgtcga catcatcttt gtcgacaagc agaatgcggc 2475181 cgacgcctga ccgcgcgaga gcttccgccg cgaacgaccc gactcccccg actccaagca 2475241 cagcaactgt gctgtttttc agcgtttcaa ggccttcttt tccgatagct aattcattgc 2475301 gtgaaaactg gtgtaacaag aacctcactc cacattcgta ttctggtttc atctataaaa 2475361 tggctgatcc atgagcagcc gttttttctg cgcacaaaaa ataaagtccc aatagtgccg 2475421 ttgcagcttt cctttgtttt gaacccgctc tcagcaggtg ggtgccctct tttaaatctt 2475481 gtaagtcctc tttaccgaat gaaaagaggc atgtacgcca tttaaaaatg cgggctccca 2475541 aatcaaaaaa atgttcggtc aaaactaggt gtacaactaa cacatcagga ctttatttaa 2475601 cttgtcaaaa tcatatcaca gacgattttg attttcaaga atcgaactgc aaattcagtt 2475661 cttaactttt ttcttgatag aaagatgaag ctcgtcaagc tgggcgtcgc ttacttcgcc 2475721 tggcgcttct gtcatcaggc agcttgcact tgccgttttc gggaatgcaa tcgtatctct 2475781 caggttcgta cgtccagcga gaagcataac gagacggtct aagccgagtg cgattccgcc 2475841 gtgcggagga gcgccgtatt caaatgcttc cagcaggaat ccgaactgtt cagccgcttc 2475901 ttctggtgag aagccgagaa gcgcaaacat tttttcctga atatcctttt cgaaaatacg 2475961 gattgaaccg ccgccaagct catagccgtt taagacgagg tcataagctt gcgctttcat 2476021 gtcttcaggc gctgtttcaa tcagctcaag gtcttctcgg acaggcattg tgaacggatg 2476081 gtgcgctgcg taaaaacggc cttcttccgg atcatgctct aatagcggcc agtcgatgac 2476141 ccataagaaa ttgaacaatt tttcgtcaat cagtccgcgt tctttcccaa gctttaagcg 2476201 cagggcgccg agtgatgcgg ccacaacttc gaattgatcc gctccgaaca gcagcaaatc 2476261 accttcagca gcatcaagtg cttcaatcag cttagactgc ttttcttcat caaagaattt 2476321 agcgatcggg cctttcactc cgtctgcctc aaccttcacc caggcaagcc cttttgcccc 2476381 gtagtttgca gcaaaagcgc caagagcgtc gatgtctttt ctggagtaat cgccggcacc 2476441 gccttttaca ttgatggctt tgaccacgcc gccgtttgct acagctgatg agaacacttt 2476501 aaattccgta tcctttacaa tgtcagacac atccgtcaaa agcatgtcaa aacgcgtatc 2476561 cggtttatca gacccgtact tgttcattgc ttcgtcatac gtcattcgag gaagaggaag 2476621 ctgaagttcc tcaccttttg tttcacgcat aacctttgcc atcatctcct cagccaatga 2476681 cataatgtct tcctggctca taaaggacat ttcaatatca atttgcgtaa actcaggctg 2476741 acggtccgca cgcaagtctt catcgcggaa acagcgggca atttgataat atcgttcaat 2476801 gcctgatacc atcagaagct gtttaaatag ctgcggagac tgcggcagcg cgtagaactc 2476861 accttcgtgc acacggctcg gcaccaagta gtcacgtgcg ccttcaggcg tgcttcctgt 2476921 taaaatcggc gtttcaatat caagaaaccc attttcatct aaaaagctgc gaacagcttt 2476981 cgtcacgtta tggcgcagct gcatcgtctg gaacatagcc ggtctgcgca aatctaagta 2477041 acggtgtttt aaacgaacgt cctctgacac ttcttcagct tgatcagaaa tcgcaaatgg 2477101 aggtgtcttt gcagcattta atacgttcac tccatcagca tgtatttcga tcgcgcctgt 2477161 tttcaaattc ggattaactg ttccctcttc acgcgccacc acttttcctt gaatatcaag 2477221 cacgtattca tttctgatgc cttccgcaat agcaagcgct tcttttgaca catcagggtt 2477281 aaaaacgact tgaacaatgc ccgtacggtc acgcaagtca ataaaaatca atccgccgag 2477341 gtctcgtctt ttttggaccc agcctttcag cgttacagat tcgccaattg ctttttcagt 2477401 tatatcaccg caataatatg ttcttccaaa caatgcgttt cactccttat cccttttggt 2477461 ttgccttcat cacatgtata aattcatcaa gtgccacttc aatctgttcg cccgtctgtg 2477521 catcctttac attgattttg ttttgggcaa gctcatcttc acccaaaatc gcaataaatc 2477581 tggcctttaa gcgatcagct gttttaaact ggcctttcat tttcttattt tcataatcga 2477641 tttcactgga aatgcctgct tctctcagtt tgtacaccaa tgaaacagaa taatcctttg 2477701 ctttttcgcc gagtgtgacg atatagcagt cgattccctt atcaacaggc agctctcttt 2477761 tttcagcatc aattgcggca agcaagcgtt cgatgctcat cgcaaatccg atgcccggtg 2477821 cttcaggtcc gccgatctgt tcgacaagcc cgtcgtagcg tccgccgccg gcaagtgtcg 2477881 taatcgcgcc aaagccctcc gcattgctca taatttcaaa tgcggtgtgg ttgtaataat 2477941 ccagccctct cacaaggttc ggatcgattt catacgaaat gccaagatca tttaagtatt 2478001 gtttcacttt ttcaaaataa gcggctgatt cttcatttaa atatgtcaaa atcgaaggtg 2478061 ccgatttcat cagctcatga tcacggtctt ttttgcagtc caaaattcta agcgggttcg 2478121 tgtgcagccg ggactggcag tctgaacaaa attcttcgat gcgaggctcg aagtgtttca 2478181 cgagcgcttc tctgtagctt ttgcggctat cttgatcgcc gagactgttt atgacaagct 2478241 taacgttttc taaacctgct ttttcataaa tactcatcgc aagcgccatt acttcagcgt 2478301 cgattgcagg gtctttcgaa ccaatcgctt caattccaaa ctgataaaac tggcggtaac 2478361 ggcccgtctg aggacgttca taacggaaca tcggcccgac ataataaagc tttgtcggct 2478421 gtacaggatt tgcgaacagc ttgttttcat taaaagcgcg aaccgcagca gctgttccct 2478481 ccggacgaag cgtcaggctt ctgcctttgc ggtcctcgaa ggtatacatt tctttttgta 2478541 cgatatccgt tgattctccg acgcctctgg caaacagttc tgtatgctca aaaatcggtg 2478601 tgcggatttc tttatattga taagtgcggc aagtgtctct cataatttgt tcaacaaact 2478661 gccagcgatc tgattctcca ggcagaatat cctgtgttcc tctcggaatg ttatatccca 2478721 taggtagacc tccttatgta ttccttataa aatatccaat gatcgttaat gatgaaaatg 2478781 aaaaaaactc ccgcccctac tatacatgat agtagggacg agagttatac ccgtggtgcc 2478841 accctagttg gaatacgttc atattcccgc tcgatccttt aacgcaggtt cacgttcact 2478901 gcctaatggc gttattcacg cgttcagcag gaaacctccg gagtgttgtt tcgagaaaga 2478961 cgcaatggga tccgctttca gcctggggcg ggttcctctc taatcatgca atctgaccta 2479021 ctcttctcca ttattggttc aaatctttca tcatttgcta tgtactcaat ttctattata 2479081 ataatgggat tggggttctc tgtcaagctt tattccggtt gtttttcctc agcgctgctt 2479141 ctttggacat aagaccaaat tcagatgctg tttccgtaag ataaccagtc gtatcgggat 2479201 ctgcgtgatc gctgtaatgc agattcgctt caccgtcgtg aaatgcacgt cccatttttg 2479261 gatgatattt catgatttgc acaccttttt gattgtattt acgcttagta taaacaaatc 2479321 attttatttt tatttaaaaa tcagaaagga ctttacgata ttaaacaaga atgctttttt 2479381 aatgatcatc agaaaggagg acacaatgaa caagaaatac tttgtcctta ttgtatgtat 2479441 tattttcacc tcagcgctat tcccgacctt ttcatccgtt acagctgctc aaggagaagc 2479501 ggtcatcgca acagatgaaa tgaacgtcag aagcggccca gggcttagct acggcattac 2479561 agcggaagta aaaaagggag aacgctatcc aattttaaag gaagatggag actgggtgca 2479621 gatacagctt ggttctggag aaaagggctg ggtagtctcc tggcttatta caaaggaaga 2479681 ccaggccagc acaagctcct caggaagcag tgacactgtg acatcaacag accccgatct 2479741 gcggatgaga agcggcccgg gcacttccta cgaagtcatc ggcaaattcc cgcaaggcag 2479801 ccaagcatct gtcattgata aagattcggg ctggatcaag atatcctatc acagtgccac 2479861 cggatgggta tcatctgaat atgtcacatc aggaggcagc agttcagcgt ctgatgagag 2479921 tgaccaaacc gaggattccg gtgcgtcaac gacgggcaca gtcggtgttt cttcgctaaa 2479981 tgtaagagcc tccgcctcac atgacgcggc aattataaca aaacttgatc gcggaacgaa 2480041 actgacggtt ctcaacgaga aaaatggctg ggctcacatt gaggtgaacg ggctaaaagg 2480101 ctgggttgca agccattacc ttttgactag ttctgttcca gctgatgatt cagcaaatgc 2480161 cggcagttca tcctccgcta aaaaagccta tatcatgtac ggaggaacga atctaagaag 2480221 tgatgcgtca acatcagctt cgatcgttga gcgcgctgcc aaaggagatt catacaccat 2480281 taccggttca aagggaagct ggtatgaaat aaagcttgat aacgggcaga ctgcttatgt 2480341 agccaattgg gtggtccaaa cgtctaaaag cgcagaagaa gcaggtgaac cgccagtctc 2480401 tgattccccg tctggaaacg gctctctaaa caataaaacg attattgttg acccgggaca 2480461 tggaggaaaa gacagcggaa cgatcgggta ttcggggaaa ttcgagaaaa acctgacgat 2480521 caaaacggca aaactgctcg ccagcaaact tagatcggct ggagcggatg tatatgtgac 2480581 acgccaggat gatacctttg tcagcctgca gtcacgggtc tctacctctc actaccgtaa 2480641 cgctgacgcc tttatcagca ttcattatga cagctatgcg gatacctcta caagaggcag 2480701 tacagcatat tactacagtc ctgccaaaga tcaggaactc gcatcagatg tccactcaga 2480761 agtggtgaag cgttcttcca ttccagaccg cggcgtatta ttcggagatt attatgtgct 2480821 ccgggaaaac agacagcccg ctatgctgta cgagctggga tatgtaagcc atccgcagga 2480881 agaagccatt gtacatagca attcatacca agaaaaagta acagatggga tcgaaagcgg 2480941 attagagaaa tacttccaat aaaaaaagct gccttttggc agcttttttt attttgaatc 2481001 cataatgagc gtgaccggtc cggagtttgt aagctgaaca tccatcattg ctccaaacgt 2481061 tccggtctcc actttgattc ctttttcacg aagcaggtca ttccattttt cataaagacc 2481121 taaagcttta tcaggtttgg ccgcgttcat gtagttcggc cggcgccctt ttttcgtatc 2481181 tccataaagc gtaaactgtg agacggataa aatctctcct cctatatcta caagagacag 2481241 attcattttc ccttcactgt catcgaaaat acggagattg acaactttat cggctaaata 2481301 agctgcatca tcttctgtat catcgtgagt gatgccgacc agcaccataa ggccttgtcc 2481361 aatttggccg acgacctctt cgtccactgt aacgcttgct tctgttactc gctgaacaac 2481421 taatctcttt tctaacccct ttagttcatg acgcggcgca cagaatagat atctctaatc 2481481 tgtttaatac gctcgacgac tttatgcaag tgattgatat tctggataaa aatcgccata 2481541 tggatggttg ccactttatt gcgatccgat ttgccagaga cagatgaaat attggttttc 2481601 gtttcattca ctgcctggag tacctcgttc agcaatccgc ggcggtcata cccaagaatc 2481661 tctatctcaa cattgtattc cttgcgcttt tgaacttgtg actcatgttc ccactctacc 2481721 gggatcagcc gctcttgggc ttcattcgtt ttgacattcg gacagtcttc gcgatggacc 2481781 gaaacccctc tgccttttgt gataaagccg acaatatcat cacctggcac aggattgcag 2481841 cattttgata aacggacaag gaggttgtca atgcccttga cacgaacgcc agcttcccgt 2481901 tttcttcctt gcgggtatgg cttaggttcc ccagtgactt cctgaacgat cttttcctgt 2481961 tcttcctggt cgcgctgctt tctctctttt tctgttaggc ggttcgccac ctgcagagct 2482021 gtgatgccgt tgtaaccgac cgccgcgtac atatcctctt catttgagaa attaaatttg 2482081 tcagcaacct tttgaatatt ctccggcgtt aaaacatcct tcaattcaaa atccaagttt 2482141 ttaatttctt tttcgaccag ctcacggcct ttttcgacat tttcttcacg ccgctgtttc 2482201 ttaaagaatt gacggatttt atgcttcgct tgggatgttt gggcaagctt cacccaatcc 2482261 tggctcggac cgtaggaatg cttagaggtg agaatttcaa cgatatcacc tgtccgaagc 2482321 ttatggtcaa gcgtaaccat ttttccgttt actttggcac cgattgtttt attgccgatt 2482381 tcagagtgaa tccggtaaga aaagtcaatc ggaacagaac cggacggaag ctcgattaca 2482441 tctccttttg gcgtaaagac atacaccatg tcagagaaca aatcaatttt gagcgattcc 2482501 ataaattctt ctgcatctgt cgattcattt tgaaattcta aaatttcacg gaaccaagaa 2482561 agctttttct caaaggttgc accttcattg gctgctttcc cttctttata agcccagtga 2482621 gccgcaaccc cgtattccgc tatttcatgc atttcaaagg tgcggatctg cacttcaagc 2482681 ggatcgcctt taggcccaat aaccgttgta tgaagcgatt gatacatatt cggcttcggc 2482741 attgcgatat aatctttgaa tctgcctggc atcggtttcc agcatgtgtg aatgatgcca 2482801 agcaccgcgt agcagtcctt tatgctattc acaagaatac ggacagccaa caaatcgtaa 2482861 atttcattga attgcttatt ttgcagcacc atttttcgat aaatgctgta aatatgtttc 2482921 gggcgtcccg agaagtcagc cttgatattt acttcttcga cacgtttctt cacttcattg 2482981 acaacctcat cgacataaag ctctcgttct gcacgtttct tcttcatgag gttgacaatt 2483041 ctgtaatatt gctgagggtt caaataacgg agcgccgtat cttccaattc ccacttaatt 2483101 tttgaaatcc cgagacgatg cgccaaagga gcaaaaattt ccagcgtttc attggagatt 2483161 ctccgctgtt tttcctgagg cagatgtttc agtgtccgca tattgtgaag acgatccgcc 2483221 agcttgatca atatgaccct gatatcttga gccatagcga caaacatttt gcgatgattt 2483281 tccgcctgct gttcctcttg agatttatat ttaattttgc cgagtttcgt tacgccgtct 2483341 acaagcattg ccacttcttc ggaaaatgct tctttcaggt catcgagcgt cacatctgta 2483401 tcttccacga catcgtgcaa aaatccgccc gcgattgtgg aagggtccat ttcaagatca 2483461 acgagtatcc ccgcaacctg aatcggatga ataatatatg gctcgcccga tttgcggtat 2483521 tgctcgcgat gagcatcttc agcgtacaga tatgcttttt cgacaaatgc gatatgctca 2483581 tcagatagat agctgcgtgc tttatctata acttgctcgg cagtcaatac ttgttcgttc 2483641 gccatggaat cacctttttt aaaatgtaaa ctgtattgta gtttattatc aagaaaaaaa 2483701 cgaaagatgt aaagagcaga agttcaaata gccaaatatt atataaaata aatgcaaaac 2483761 aataggaaaa aagcaccctg acatggagtg ctttttcgtt atgcggttat ccttagtatt 2483821 tcatcaatgt taagatgtcg taatcttcga gcttatttct gccgtcaagg taagaaagct 2483881 cgattaagaa agcgatacca gcaacaacgc cgccaagttc ttcaacaagt ttgattgtcg 2483941 cttcaattgt gccgcctgtc gcaagcaggt catctgtaat aagcacacgc tgaccaggct 2484001 taatcgcatc tttgtggatc gttaatacgt cttttccgta ttccaagcca taatccactt 2484061 tgattacttc acgaggcaac ttgccttctt tgcggaccgg cgcaaaacct acgccaagcg 2484121 cgtaagcaac gggacagccg ataataaagc cgcgcgcttc agggccaacg accaaatcaa 2484181 tttgcttttc tttcgcatat tcaacaattt gatctgtggc atagcggtat acatcgcctt 2484241 tatccatcag tgtcgtaata tctttaaatt gcacgccctc tttcgggtaa tccggtacaa 2484301 ttgttacgta ttgttttaaa tccatctgtt ttatgtcctc ctcgtacttt cataagcctc 2484361 tgaatcttgt ttcatcagct tattcagcca ttccttcagc tcttcagcag aagaataatt 2484421 cagcttttga tccagttcca tcagctgctg tttcgcctga tatgtttgtg agtctgttaa 2484481 gtcgcgtttc tttgctccgc tcacaacaga cagcacacca ttctctattt taacaaaacc 2484541 gagatcaaaa aacacctttg tcatgaaatt gattgtttca acggaccagc ctttatgttt 2484601 tgcaagctct gaaccgtgtt ttttcacgtc aaaagcgcct cttttcagca agaacgcata 2484661 ataccattta aagtggtctc ttgcgggaaa agttgataaa aagtggtcct catgattgag 2484721 aaaaataaaa tatatccgct cgggcgcctt tccttccagc aaacgtgcga gcatgtccag 2484781 cgaaggcggc ggatccagta atacaatata tgcaccatcg aggtcaaacg cctttgcttg 2484841 atctttagaa ctgatgacgt gcacttctcg gcgaaggtct tcagtttgaa gtaatgttgt 2484901 tgagtcttct ttgaaagaga caatggcccg tttagcagat ggaagggcgg aaactgtgtc 2484961 ttcccacgtc cgttttcccc ttaaatcaaa cagctgccat tcagaaacag cggcatcctt 2485021 tatcataagc tgcggctttt ttcgattgtt ccattcgttg attgacatct caccgacaat 2485081 ggaaattctt gaacccggta cgatgccttc ttgaagctcg cctttattaa aaccgacgca 2485141 atcaagctgg gacgactcgt ttctgatcgt cattttgaca tgagttttat ttgcccctat 2485201 cttgcggaca tcttccagta ctgcattttc tacgagaacg tgcggtttcg ggttcagcat 2485261 gccaaaagga gacagcatgt tcatttctgc gatgctttca actgtaatgt cttcgacgcc 2485321 gcagacaagg tcgacttcct gtacgggaat aaaatcctct tccgtaagcg tattgtccgc 2485381 tatttcattc agcctgcttc gcaaatccgg cacatcttcg gctttcagcg tcatccccgc 2485441 agccattgga tggccgccga aatgaggaag aatatctctg cattcagaaa ggctctcaaa 2485501 taaattaaat cctctgatgc ttcgggccga acctttagcg attccctttt cttcatcaat 2485561 accaagaaca atggccggtc ggtagaaacg gtccacaagc tttgaagcca caatcccgac 2485621 gactcccggg ttccatccgg ctttggccac gacaattgca gtttgatcga gcccttgctg 2485681 ttcaaccatt tcaatcgctt catccgtcat tttgctgacc attttttggc gctctttgtt 2485741 cagctggtca atttctgcgg caagctcttc cgcttcaaac gaatcctctg acataagcaa 2485801 atgaacagcg ggatccgcct gttcgattct tccgacggca ttcagccttg gtgcgagctg 2485861 aaatccgact gtttcttcgt tcgcttctcc gatgtctccg cctgacagct taatcagctc 2485921 ttttaagccg agccgatttg tccgtcgaag cctttcaagt cctagtgttg ctattaatct 2485981 gttttcgtca tgcagcggga ctagatcggc aatggtgccg atagccgcca ggtcaagcag 2486041 ttcatcagga agttcaccca ataaagcgtg ggcaagctta aacgcgactc caaccccggc 2486101 aagctcttta aacgggtaag tgcagccagg ctgcttcggg tggacgatcg cacggacatc 2486161 cggaagctcc ggtcccggtt catgatgatc ggtaatgatg acatccagtc cgagttcctt 2486221 tgccaccttc gcttcatgca cagcggcaat tcctgtatca accgtaatga tcaaagagaa 2486281 gccccgttct ttaatcgaac gaaacgcctg ttcattaggt ccatatcctt ctttaaaacg 2486341 gtcaggtata taaaaatcaa cttgagccga cagtttttgc agcgtgtgaa gcatcactga 2486401 cgtacttgta accccatcgg cgtcataatc gccatatatc ataatctttt cttgttgtga 2486461 aatcgcctgt tttattcgat ctgccgcttc tttcatgcct ttcatttcaa aaggatcata 2486521 aaaatcggca tcctttgtat gtaaaaacag cctagcgctt tctgccgtat caaagcctct 2486581 ttttacaagc agggacgcaa caagaggtgt tatatgcaat tgttctgtga gtgatttgac 2486641 cttatcctga tctggtcgct ggatttccca tcgcattttt gacgctaaca taaattcacc 2486701 cctcaaccac cctattatac tagagcaggc tgaggggttt caaataatat tcgaaaacta 2486761 gtcttttttc tcaatcatgg ctgatgcatc ctgtgtgtca gtctgatcag caagatgagt 2486821 atcctcttgt ttatgtattg ctgttctatt ttctttccgc aaggttttta tttcccgctt 2486881 caatttcatt acctgaaaaa tgccgacaga aaatacgatc agtgctccca ttaaaactga 2486941 gcccaaaata acaagaatga gcggccattc tgatcttcca aacaggtaat caacttctac 2487001 ggatcgaaca ttaatgactg cgaaaatagc gacaattaag gtgaaaataa gtgcgaaaat 2487061 aatggtccat tgtttattca ttctcttttc ccccaaactt cttattgagg taactttccc 2487121 aatcaagact ggttttaaac atggcttaac actaggttaa gctccctttg ctgttaattt 2487181 ttcccggatc agcctcttca gtccggttcc ctcaccggaa atcacaagtg tatcgccttc 2487241 gtcaatgact gtttcagagc tcggattcag ttgtttatcc tgattctttt taacaattgc 2487301 aatgaccgtc acatgatatt cctgacccac attcaaatca ccaatcgtct gatgaatggc 2487361 aggcgctccc gcctctgctt tacaccactc tataatcaaa tcatcaaggg ctgactcgac 2487421 ctgttctaat gctttcggtt tatatgccat tccgccaaga attgcagaca tttgccttgc 2487481 ttcagcgtca tcaaactgca cggaggcaac acattcctca tggtcgtttt cgtcaaaata 2487541 gtaaagctct ctccgtccgt catgatgaat gataattgaa attttatcac ggtttctagt 2487601 aatcatttca actttttgtc ctatgcccgg cagctctgat tcgcgaaccc tcatatataa 2487661 accctcctac atatctgaaa accagccata aacactttta acaccatata tatgtttaaa 2487721 tgtaagcgta tgtcattata gcaaatgtct attttaagtt caatgaaact tcaaaaaaca 2487781 ggctgccctg cagaggacag cctgatattt tttattgcgc cgaatctttt ttcagttctc 2487841 ttcctttcca tgcaagccaa atttgtgcgg caatgtatag agaagaataa acgcctgtta 2487901 acagcccgac caataaagca attgagaagt tagtaataga agatgctcca aagatcagca 2487961 atgtcacaac aacaatcaca acggttaata cagtgttaat tgaacgtgta aaggtttgct 2488021 gcaggctcag gtttacaata tggttcagat cggcaaaggt tttcggctta cgctttttca 2488081 tatgctcgcg gaccctgtca aatgtaacga ttgtatcgtt aatggaatac ccgattatcg 2488141 tcaagatggc cgcgatgaat gtaacatcta cctcaagcct tgtaatactg aagaacgtga 2488201 cgataaagaa tgcgtcatat agcaatgagg cgatggcagc aatcgccatt ttgtattcga 2488261 atcggattga aacgtaaata atgatgccaa tagaagctat agcaactgcg tacagcgcat 2488321 ttctcgccag ctccttaccg actgtcggtg aaactgtgct gacatttgga tcagatccgt 2488381 atttgtcttt aaaatacgtt tttacttttg caatggtttc tttatctggc accccgacaa 2488441 aacgggcaac accgatattg ctcttttcgc ctgacagaac tacagtatca gggtccatac 2488501 ccagagattc aaaatccttc tcaacttgct ctgtcgtcag cttatggtcg ctttgcactt 2488561 caatccgtgc accgcttgca aagtcaatgc caagattcag cctgaacaca agcaggataa 2488621 taatcccggc aaccgtgacc gcactggaga aaataaagaa gtatttgcgt ttgctcgtga 2488681 aatcccattt ttggaatggc gtatgcggct ctgtattttc atccgtatcc tgaatatcca 2488741 tgatatgttt cttattgaca ccaaaccagc cttttttccg atcaagccat ctgctttcca 2488801 caaggagagc gaggagaaat ctcgataaga aaacggcagt gataaagctt gtcaaaatcg 2488861 ataggatcag cattgtcgca aaccctttaa cagagcttgt cccaaagata aagagcacaa 2488921 ccgctgcaat aatggttgta atattcgcgt caaaaatcgt cgcaaatgac cgtctgtttc 2488981 ctgaacggaa ggcagagcgg actgactttc ctagcttgag ctcttcttta atccgctcat 2489041 aggtaataat gttggcgtca acagccatcc cgacacctaa aatgagagcg gcaattcccg 2489101 gaagcgtgag tacggcattc atccagtcaa agatctggag tgtaatgtag atataaacag 2489161 acagcgtaat caccgcgatt aatcccggca gacggtaata gaaaagcata aataagaaaa 2489221 taattgcgat accgacaata ccggcaaaca ccgtatcatg gagagcctgc tggccgaatt 2489281 gcgcgcctac tgatgtcgaa tacttttcag tcagtttcac aggaagtgcg cctgcgttta 2489341 aaatgctggc taaatctttc gcttcttgag ctgtgaaatg accttcaatt tttacatcag 2489401 ttgtatttag ttcctgactt acatttggag cggatacaaa tttaggatgc tctttttgaa 2489461 cttctttctt aaaggaatca cctttatcat aatccaacca aatgacaagc tggttgtttg 2489521 gcgccatttt catgaccttc ttggtcactt caccaaattt atcagcgtct ttcagcttaa 2489581 tcgtgacaat tggctcattt gttgtgctat cataagtttg tttagcgccg ttttcgacta 2489641 gatcagcacc gtttaacagt tccttatcat ttgcatctct gaaagaaagc tgcgcttcag 2489701 tcgccaaaat ttcacgcgct ctgttttggt ttgtcacgcc agcgagctga acgcgaatcc 2489761 ggttattccc ttcaatttgg atgttcggtt cgctgacacc gagaacattg gcccggcggt 2489821 tcagtgcctc tactgtgctg accagaacgt cttttgtgat tttgtcacct ttttttacag 2489881 gctgtacatc atacagcacc tcaaatccgc cttgcaaatc caatcctaac gtaatattgt 2489941 tagcggcagg cttcgtaaag tagcccaagc ccgtgccgat caatagaacg aaaaggaaaa 2490001 acgcaatcaa gcgtcctttt ttcattatgt atatcctccc ttaaacctgt gcgaatcaac 2490061 ctgctatctc agcagttctt ccaatgcttc ctggccctct tcactgccca gccaattaga 2490121 cgttttaaat gactcaacgg ttgcatagtt cataaattcg ccaattttca ctgataaaat 2490181 atcactcgcc agttcataaa tgctcagttc cgttttcttt ttccacttct tatctgttaa 2490241 gtatgaccac aaactttcga gttcaacatc atcatacccg agaatcttaa actcttccag 2490301 tttgctgtaa agaaacggcc tgacgtggtc tttatataga tcggctggat gcttctccac 2490361 gaattccacg ctcctttttt attgtttttc aagaagactt gtcatgcttg gacgacatat 2490421 acgcatatct ttattgtata tgattccagg tagtttgaga aggcaggggg taaaaatggc 2490481 gaaacagacg tttttaaagg gcactcttat ccttatcgca gcaggaatgg ttacaagaat 2490541 gctcgggttt gtcaaccggg tggttatcgc ccgttttatc ggtgaagaag gagtcgggct 2490601 ttacatgatg gcagcgccta ctttcttctt ggccactaca ttaactcaat tcggtctgcc 2490661 ggtcgcgatc agcaagctag tcgctgaagc cagtgcgcgc ggagatcatc aaaaaacgaa 2490721 aaatatttta gtcatgtctc tgaccattac gggagtgctc agcctcatct ttacaccgct 2490781 gtttctgttt ttcgcccctg ttatggctga aacgatgctg acagataagc gaacactgta 2490841 tccgctcttg gccattacgc ctgttgtgcc gattattgct atatcgagtg tgctgagggg 2490901 atactttcaa ggaaaacaga atatgaaccc gcttgctatg tcacaagtcc ttgaacaggt 2490961 tgtccgcatt tcactcgtgg ctgtctgcac aacgattttt ctcccttacg gaattgaata 2491021 tgctgcagcg ggggcaatgc tatcctcagt ggcaggggag ctggcatcac ttctttattt 2491081 attcgtttgc tttaagtata aaaagacaat taaaatcaga aagcattttt tacagtcaat 2491141 taaaaacgga aaacaaacct ttacccaatt aatgagcgtg tcccttccaa caaccgggag 2491201 ccgctttatc ggaaacctct cttggttttt cgagccaatc gtcgtcgctc aaagccttgc 2491261 catcgccggt gtggcaacag ttgccgcaac aaagcaatac ggggaactaa ccggctttgc 2491321 catgacgctg ctgactctgc ccagctttat tacatattct ttgtcgaccg cgcttgttcc 2491381 tgcgatcagt gaaggaatgg agcagaaaaa attgcaggtg gtggaatacc gcttagaaca 2491441 ggcgatgcgt ctctgtctgc tcagcggagg catttcagtt gttattttat ttgtatttgc 2491501 ggatgagctg atgagagtga tgtacggttc ctcaggcgca gctgtattta taaaagtgat 2491561 ggccccgttt tttctgcttt attatttcca aggcccgctt caagctgtgc tgcaggcgct 2491621 taatttggca ggagctgcga tgatgaacag cttaatcgga gcgcttgtca aaacaggcct 2491681 tatttttgtc cttgccacaa ggccttctct tggcattatg ggcgcggcat tagccattgt 2491741 gacaggcatg gtgctcgtca cgctattgca cgcagcaacc gtaagcaaag tgctgccgat 2491801 cagcatcaaa atcaaggagt acgcgctcag cttcgctgtt attgtaattt gcggattcat 2491861 cagctccgcc atcaaacaat atataagctt tggagcatct gaggctgtca atctagccgg 2491921 atggattgcg gcgagcgccg ccatttatat gatcctcctg ctcgttttcc gtttaattaa 2491981 aaaagatgag cttcgccgca ttcccattat cggacggttg atcatccgat aatggtcacg 2492041 tgcggtgccc atctttttca tcaatatata tttctccgtc tgtaaacgag caaaatgaaa 2492101 tatctgaagg gtttgtgtat ccgtgttttt gcaaactttc aagcagccat tttctatctt 2492161 tactgattct ggacaggttt tctgtttgaa tgaagccgtc tataatgagc ggcatttcga 2492221 gctgccgatg ctctccgctg ttttctttct taacaatagt cagtttgccc gacggctcta 2492281 aaatagcaaa tgatacgtca gctactctgt cgatgctatt ttctctgagc tgaaccatta 2492341 aatcatcaaa attataacgc tgtgatttca tggcttcttc gtcaattttt ccatatttga 2492401 taattatggt cggcttaccg tcaagaagct ggcggacttt tcggtttttt aaagaaaagt 2492461 atgccaaagt cacttgaatg atcattaata caagcattgg caaaatggta tgaaatagat 2492521 gatcgtctac gttttctatg gctaaaacgg caatttcagc catcatgata aagacaacga 2492581 gatctaaaat actaagctct ccgatctccc gtttgcccat gaaacgaaaa atgaccaata 2492641 tcacaaaata caatacgact gtgcgaaacg caatagtgag aagctcttcc attatgcacc 2492701 tccaactcat tataggttgc aacaaaatga tcaatttatg taagaaaaac cgattgcatt 2492761 tcacaaagct tttacgtcta attcatggga taagggaata catttttaca aagacgagcc 2492821 atcagcatgt ctgacggttt tgaacaaaaa gaacagaagc cttttaatac aggcagagag 2492881 gagacaatca tggaggaaac gaaacaagtt ggaaaaggca ttctttacgg cttaatcgcc 2492941 atattttcag ccatgctcct gacaagttta gcggtttcac ttttattgac cgcaacctcg 2493001 ctggaagaat catcatttaa ctggctgatc accgctatct catttctctc tttatttatc 2493061 ggcgggttca tttcaggcgg gaaaggcaag gaaagaggct ggatgattgg cgcattgacc 2493121 gccttaagtt tttctctgat tatcttattg tttcagtatt taggattcgg aaagacattt 2493181 acagcagaac agctgatctt ccatctggga tttttagggg tgtgcatgct gggcgggatt 2493241 ttcggcgtga acatgagggg aaacaggtct tccacataaa aaagagcggg ctcacttgcc 2493301 cgctcttttt tgtttgctat gtatagctcc tgctgttatt cagcagcaga aacttctctg 2493361 atcgcgcggc ggtcgaacgt aagacgtgtg ttatcaccag tcttaattac gactttgctt 2493421 tcgtcgatag agtcaacagt accgtgcaat cccccgattg tcactactga atcgcctttt 2493481 ttcagttcct cttgcatttg gcgtacagcc ttttgctgct tttgctgagg acgaatcagc 2493541 aagaagtaaa ggaccgcaaa cattaaaata ataggaacca atgtacctaa agtgccagtc 2493601 atcattttca cccctttctg taagcctgtt atgtttattt agaagctttt cgcatttggc 2493661 ttgttatagc cgtaacgctc aaagaactct tctctgaaat cacccagacg atcctcgcga 2493721 atagcctgtc ttacctgctc cattaagtgt aacagaaaat gaaggttatg gtaagttgtt 2493781 aatcgaaggc cgaatgtttc attgcagcga atcaagtgcc taatgtacgc gcgagtgtag 2493841 tttttacatg tatagcaatc acactcttca tcaatcggac ggaagtctct ttcaaatttc 2493901 gcatttttca tattgagtcg tccttcagca gtaaacactg tgccgtttct tgcaatccgt 2493961 gtaggcagca cacagtcaaa catatcgacc ccgcggatcg ctccgtcgat cagtgcgtcc 2494021 ggagaaccta ctcccatcag atatctcggt ttatccttcg gcaagagcgg tgttgtgaat 2494081 tcgagtacac ggttcatgac atccttcggt tcacctacag acaatccgcc tatagcatat 2494141 cccggaaaat caagcgaaat caagtccttc gcactttgtg tccgcagatc ttcatattct 2494201 ccgccttgta caataccaaa cagcccttgt tcatcctgac gattgtgggc attcaggcag 2494261 cgttccgccc agcggcttgt ccgttcaact gacctcttca tgtagtcgta ctccgccggg 2494321 tatggcgggc attcgtcaaa cgccatcata atatcagagc cgagtgcgtt ttggatctcc 2494381 atcgcttttt ccggagataa aaacagcttg tctccattta gatgattgcg gaaatggaca 2494441 ccctcttcct ctatattacg aaacttgctt aaagaaaaga cctgaaaacc gcctgaatct 2494501 gttaaaattg cgcggtccca gttcataaat ttatggagcc cgcccgcttc tttgacaatg 2494561 tcttggcccg gacgaagcca tagatgataa gtgttgctca aaatgatgcc tgcatccatt 2494621 gctttcagct cttcaggcga cattgttttg actgtcgcca gtgtgccgac cggcataaaa 2494681 accggcgttt cgaaggagcc gtgaggcgta tgcactttgc ccagccgcgc tcctgtttgt 2494741 ttgcattctt ttataaattc atagcgtatt ggttgttcag ccacttttga tgaggcctcc 2494801 tgttctcaaa ttatataatc agcatcgcgt ctccgaagct gaagaaacgg tattcctctt 2494861 ccactgcatg gttataggca cgcagaatgt tttctcttcc agcaagcgcg ctgaccagca 2494921 taatcaatga cgatttcggc aaatggaagt ttgtaatcat tccgtcaatg gctttaaatt 2494981 catagcccgg ataaataaaa atagatgtcc agccgcttga tgctttaaat tgcccgtcat 2495041 gttctccggc aatcgtctca agcgtgcgtg tcgaggtcgt gccgacagaa atgatccgac 2495101 cgccattttc tcttactttg tttaaggctg cagccgtttc ttctgacatt tgataaaact 2495161 ctgcatgcat attatgctct tccacttcat cggcactcac agggcgaaac gttccaaggc 2495221 ctacgtgcag tgtgatgaac tcaatttgca cgcctttgtc tttcagctgc tgtaagattt 2495281 cttccgtgaa gtgaaggcca gctgtaggcg cagcagcaga gccaatttct tttgaataca 2495341 ctgtctggta gcgctctttg tcatcaagct gttctttgat atatggaggg agcggcatct 2495401 ctccaaggga ttcaagcacc tcgtagaaaa taccgtcata ttgaaattcc atctttctgc 2495461 cgccgtgctc aagctcttcc gtgcagattg ccttcaatct tccgtctcca aatgtgacaa 2495521 cagttccttt tttcacccgt ttcgccggtt tggcaagtgt ttcccattta tcaccggttt 2495581 cctgtttcaa caaaagaagt tccactttcg cgccggtatc ctcttttgtg ccgaataacc 2495641 gcgcaggcag tacccgggta ttgttcagga ctagacaatc gccttcgtta aagaagctga 2495701 taatgtgttt aaacgagctg tcagtaagct ctcctgtatg tttatcgagc accatcagcc 2495761 ttgaagcatc acgctgctcc aacggtactt gtgcaattaa acgttctggt agttcaaaat 2495821 caaataaatc gactttcatg atgatttcac ctttattcta gtcttttgtt atttcattct 2495881 gccaaaaaga ttaagcaaaa ttgataatac cacacttata ataatacaag tgacaaccgg 2495941 gaagaaaaac gtaacatttc ctttttttac aaaaatatct cccggcatct tgccgacaaa 2496001 atgcaaaact gctccgataa taagcaaaac agcaccaaga atcataatga tcttaggaaa 2496061 ttcagtcata tcggggagcc tccatttgga aatgatgata aacggccggt gtcacgatcc 2496121 ttccacgcgg cgttctttgt ataaatccaa tttgcagcag atatggttca tatacgtctt 2496181 caatcgtatg cgattcctcg ccgatggtag ctgaaatcgt atcaaggcct actgggccgc 2496241 cgttgaattt ttcgatcatg cccatcagca gcttatgatc aatatgatcc aaaccgaggc 2496301 ggtcaacctg aagccgctcc agcgcattct gagaaatgtc ttccgtaatc ctgctgtcac 2496361 ccagcacttg ggcgaaatcg cgcacccttc tcagcaggcg gttcgccacg cggggcgtcc 2496421 ctctcgatct tcttgcaatt tcaagagccg acggtttatc aatctcaacc tcgaatacat 2496481 cagcggttct tgtgacaata tccgccagtt cttcttgtgt atagtactca aggcgagaca 2496541 ttacgccgaa tctgtctctt aaaggagccg tcaaaagccc caccctcgtc gtggctccca 2496601 ccagcgtaaa aggcggaagg tcgaggcgaa ccgagcgggc agatgggcct ttgccaatca 2496661 caatgtccag gcaaaagtct tccattgcag gataaagcac ctcttcgatc gatctgtgca 2496721 gcctatgtat ttcatcaata aataatacat ctcccggttc cagcgccgtt aatatagcag 2496781 ccaaatcacc aggcctttca atcgcaggcc ctgatgtcgt ccgcaattcc actcccattt 2496841 cattagcaac aatcgaagca agcgttgttt ttccgagtcc gggcggcccg tacagaagaa 2496901 catgatccag cgtctcctgt ctcattttcg ccgcatctat aaacacgcgc aaattttctt 2496961 ttaccttatg ctgcccgata tactgtgcca gattttgcgg cctcaggctt tgctctatca 2497021 ctgattcatg gttgtctgct tcacttgaga cgagccgttc atccatgaac atcaccttac 2497081 tttaatagtt tttgtaatgc ttttttcaca tattggtctg ttgtcagccc aatttcttct 2497141 ttaaggtgag gaagcacctt tttgatttct ttttcagcat atccgagaac cctgagggct 2497201 tcaagtgctt cttcaagagc cgtttccgct gtttgctttt caagcctttc ttcatgatta 2497261 aacagatttt caatcatttc aggcacaaca tctgccagct ttccttttaa atctagaata 2497321 atctggcgtg cggttttctt tcctactcca ggaaacttga ccaaaaaagc ttcatcttca 2497381 ttttcaattg cttggatgac cgctccggga tcacccgagc ccaagatggc aagtgctcct 2497441 ttcgggccaa ttccggtcac gtttaacagc tttgtaaaga gcgccttctc ctctcttgtt 2497501 gaaaaaccat aaagcgaaaa agcatcctct ctgatatgat ggtatgtaaa aatcgtttct 2497561 tggcttctct ccttatatat aaacggattc ggcgtgaaaa tctgatagcc gatgccgccg 2497621 ttctctatga caatatattg gggagataca taatcaatcg tccctttaac aaattcaatc 2497681 acgcaaattc acctctttga ctgttcttca ttgtaccata aaaacagcca aagtcttata 2497741 gaaaagttaa catatgttcg cttctctctc attctttcac gaaaaaaaag acatgaatac 2497801 atgtcttcaa tcagcggacg ctacccgctg tatgtcttca tatgttcgat gacatcctca 2497861 aactccgctt ttgtccgaaa tggaatgcct ttcagcagat ttttttgcat atggctttcc 2497921 agcctttcta aatcaatttg aaaaaaagac tgaattggtt cggaagctgg ctcaggccgc 2497981 ccatgaaaag tggaaatcac tccattatcc gatacaccga tatacccgtt gaccttgctg 2498041 agcggagaaa tatcgtccat ttgcttccgg aagagcacat atcccttttt ttgttccact 2498101 agcgtccatc cggcataagc tgcccaaaaa tcatccatag aaaacacttt ttcatgctta 2498161 tgctcaatgc tgacatcgcc gtccaaatac accttttcaa gctgcacatg cacctgcagc 2498221 ggctcatagt gctccacttc cgcgccaagt gcgcgggaag gagctcctat taaaaatact 2498281 gccgctgagc aaagaatgcc cagcaaaaga tacgccgtgc tgaatcgttt caccctctac 2498341 acctctttgc acacgtttat gattagtttg accaaagagg ctactgctta accgttttat 2498401 caaaatttgt ctgcacattt tccctgacaa accgttcctc cgtatacaca tctgtgcttt 2498461 gctcagaaat tgtcaagaat cgcgtcagaa aggcactgaa aaaatacaat gccgcaaaga 2498521 tccaaatcac gccacctgca ccgagcggcc caatgaaaag actcacgatg cccggcgcga 2498581 taaacgcaca taaaccagat cccaaattca acactgacat ggcagcacct ttattatcag 2498641 gtgcaagcgt cggcaaaagc gcgcttaatg ggacgtaccc tgctaaagcc gcgccgtagc 2498701 agcaggcgat aatcatgagc acccaatact gatgcccgat cagctgaggc gtgtaataca 2498761 gcgccagcgt aaaaataccg catccgacac cgccaaacca catgaccgta ttgcgccagc 2498821 ctagtttatc tccgactgca ccgaaaatga tattaaacac aatattcaca aaaaacagcg 2498881 tcccccatat ttgcagccat tccgaaaccg aatacccgta tcgtgctaaa taagtaggaa 2498941 gaaagatggc aaatccaaat tgtcctatcg cattaatcgt cttgaccact ccgccgatgc 2499001 ctaccttagg gttttcaaac ataatcgtaa atgccttcga cagttctttc catttcggct 2499061 gatcttgttt ttgtatcgga gtaaatttat ctttgttaaa aaataaggca agaattccgc 2499121 ctgccgccac aaacagtaaa gcgctccaaa gcgtattgat ttctccaaag gccggaactg 2499181 catagctgga atagaacgga ccgagcacgt taaggccgca cgtaaacata aaccaaaacc 2499241 agccgacggc ttttccaaga atattttgag aggtgctgta tgacacccat acgagaaaag 2499301 agtatgcaaa cagcggatat cccaagcctc taagagcata gctgcccaag agagccggat 2499361 aatacatatg aggaatcgcc cagccgataa aagcggccga accgaggata aatgcaagca 2499421 atccgacagt catcgttttt ctcggccccc aagtttggac aaacgttcct gaaagccaag 2499481 ctgagatggt gacagcaatg ccgtacatgg taaataacga tgcggattgc tgcatactga 2499541 gaccatgatc aacgagaaaa ggagacagcc agccttgttc gaggccgtct ccaaccataa 2499601 agatgacaac gccaatataa ccccaaacca tgtgagaagg aattccgatt ttgttcaaaa 2499661 catttccttt agcatgtact gtattcattt tctccaccgc ctacttaaag tatcaatgga 2499721 gtatataccc aagcttgctg aattgtaatc ctgttagatt aaaaagcgat tttttcagtg 2499781 tgctcaatgc taacaggcat gccaaaagca agcgattgct gtgctgctct ggcgatcctc 2499841 ccggcctgta aaccgtcatt gccggtgcag ggagtctcct ggtttgtgcc gatcgcttct 2499901 gcaaaacgga gaatctcctc ctcatatgaa tccttatagc gttcaaggaa aaagaaatgc 2499961 ggtttatcct tcatcacaaa atcagctgtt gacacctcaa ccgttgtcgg cctgctattg 2500021 tcagccgctg cagagccttt cgtcccgaaa acctcaaccc gctggtcata tccgtacaca 2500081 gcttggcggc tgttatcaat cacagccatg gcaccgtttt caaaagtcag tgtaataaca 2500141 gctgtatcaa tatcacccag ctccgcaaaa gaaggattca ccaaagccgc ccctttggca 2500201 tacacttccg tcacttcgct tcccataata tatctggcca tatcaaaatc atggatcgac 2500261 atatccataa acaatccgcc tgacgtacgg acataatcta tattcggggg ttctgggtcc 2500321 cgggacgtga tttttaataa atgaggtgta ccgatttcac cattttcaac aatcgttttg 2500381 attttcttaa aatgaggatc aaagcggcgg ttaaatccga cttgaagtgt taccccgtgt 2500441 ttccggacag ccgcaagcgc ttcactcgtt tcgtccagag agaaactaac gggcttctca 2500501 caaaatatat gctttttcgc ctcggctgct tctttgatca tctgtgcatg tacggctgta 2500561 ggagagcaaa taaaaatagc atcaatatca ggatcatgta ataaatcacg ataatcagag 2500621 gttatgtatt caatctgatg actgtcggcc cagcttttta tacggctcgc ctgaatgtca 2500681 gagattgctt ttattttcat gtgaggaatc cggcttatat tttgaacatg aagtttgccg 2500741 atgcggcctg caccgataat ccctgtcaca atctgttttg tcatggcttc ttcccccttg 2500801 atcattcacg aaagcgcttt atttaaaatt aatactatcc catttgtaag cgcttttcaa 2500861 gaatggaaat taaacgttct atgtctcttt tatcacaatt catgcttata agtagccttc 2500921 ttcttcaaga ccagatacac tagaattagg ctctttttcc tgaacagttt atgattttcc 2500981 tataaacagc tgcataaaat agagcaaaga aggtgaatga aatgctgaca aaagcagagg 2501041 cactggccca taccgtcata taccgcaaga acagcagatt tgataaagtc aaagagaaat 2501101 ccgaggaatt aacactaatc ggcaagggaa gaagcgccta tgtgtttgcc ttaacagaag 2501161 gcggtcgaaa aatggcgctg aaagtatttt ttccggaata tcaagcgaca gcagtcaaag 2501221 aagcagcgat ctatgaaaaa ttagccgggt ccgcattcta tcctgacatt tacgaaactg 2501281 gcgattcatt tattctcatg gaatatatta aaggtgaaac cttttataac tgtctgaaga 2501341 aaggcattgc aatcagtgat gacatgattc agcaggttga agaagcgctt tctgacgccc 2501401 gggcagccgg actgaacccg tcagatattc atttgcggaa tctgatattg acagaaaccg 2501461 gggcggtgcg ggtgattgat gttgcgagat ttgagcagac aaaaacatgc acgcagtggg 2501521 acgacttaaa atccgcatat catgcactct acaaaaaacc gatattcccc aaaaagattc 2501581 cgggtttttg gctggagatc atcgcatttt tatataagaa agattggttt caaaagcatt 2501641 tcgcacagcg gaaaagaaaa tattcttaaa tcaaaaaggc agccgcacaa gcggctgcct 2501701 ttatcatgta ttttttactt tctgacggca gaaatcagtt tcatttgttc aggcgacagc 2501761 ttaattcgat agcctctcac agttaagtag accgcttctg ggtccttctc gccggaatga 2501821 caatacgttt tttccatttc tgtctcccct caccctttat tggctttatt tcatcttatc 2501881 attgctttat tgaggtaatt ttaaagaaat gtaaagatta tatgaatccg atatatagta 2501941 aaatgagaga aaaaaaggga gagagtcaca ttaagaccga aaacaccttg agcttagatg 2502001 cagccagagg tgaacttgta aatgaaaaaa cacttgtcaa gagaacaatc tactggaatt 2502061 acccggacag ccgcccagca gtgacgtgga tcaatcacaa tacagtgaaa atcggcaatc 2502121 agactttaca tcttgatact gatgaaacgt atgattggcg aaaagatgat cattggatcc 2502181 gtgaagaacc gccgcaggcg tcagtgaggt gatgaaacat gaataagatg aacggaacaa 2502241 atgatgaaaa gcatttcaat cattttgtga ttgctttatc ctttatatac ggtttgactg 2502301 aactaggcta tttgttgctg aaggatttta taacaattgc cataagtttg cctctgtaga 2502361 aaaacgcagc gtagtcgata cgccgcgttt tttctttttc ccttcctctt cttattgata 2502421 attacaggtc atataatgtg acaaatcgat tgtagaaata gttcgattag accaaaatcc 2502481 tttttataca tgtattcgaa tttgaagtga gggggaagct tgatggcaga ttttgttgct 2502541 agtttgaatg cggtcttatg gagtacgccc gtcatttata ttttattggg aattggattc 2502601 gccttttcaa ttatgacccg ttttttacaa gtccgacatt taaaagaaat gattgttcag 2502661 atgttcaaag gcaagagctc tgaagccggc gtttcatctt tccaagcgtt atcgattgcg 2502721 ctgtccggcc gtgtgggcac aggaaacatc gcgggagtgg cgacagcaat tgcattcggc 2502781 ggacccggtg cagtgttctg gatgtgggcg attgccttta tcggggcggc gagtgccttt 2502841 gtagaatcaa cgcttgctca aatttacaaa gtgaaacaag acggtcaata tcggggcggc 2502901 cctgcttatt atatagaaaa aggcttaggc attaagtggt ttgccgtctt atttgccgct 2502961 gctgccctta ttgcaatggc ctttctaatg ccgggcgtac agtccaactc cattgcggct 2503021 gggatccaaa atgcattcgg catctctcct ttcgtcacag ggtgcggtct ggttttatta 2503081 ttagggttca ttatttttgg cggcgtcaaa cgaattgcca atgcggcgca aatgattgtt 2503141 ccatttatgg ccattggata tatcctgctg tctttgatta ttattgtcat gaatgtgtct 2503201 gaattgcctg ctgtgatctc attaatattc aaaagcgcct tcgcattgga ttccgctttt 2503261 ggcggcttga tcggtatggc gatttcctgg ggcgttaaac gtggcattta ctcaaacgaa 2503321 gccggccagg gaacaggccc gcatccggca gctgctgcag aggtttctca tccggtcaag 2503381 cagggactgg ttcaggcatt ttctgtttat attgacacct tgtttgtatg ttccgctaca 2503441 gctttcatga tcttgtttac cggcatgtac aatacccagg ctgcagatgg ttcctttatc 2503501 gttcaccagc ttaaaggcgt agaagcagga cctggtttca cacaagcggc aattgacagt 2503561 gttcttcccg gattcggtgc aggctttgtt gccatcgctt tattcttctt cgcttttaca 2503621 acaattatgg cgtattacta catcgcagaa acaaatatcg cctatttagc acgaggcaga 2503681 gaaagcaaat gggcgatgct tggcttaaaa ctgattattt tagccgccac gttctatggt 2503741 actgtgaaaa cagcttcact tgcttgggca ttaggggatg cagggcttgg cattatggta 2503801 tggctgaacg tcattgccat tgtgctgctt gccaagccgg cgctccttgc tttaaaggat 2503861 tatgagcgcc aaaagaagca gggcttagac ccgatctttg atccaaaagc gctgggtatc 2503921 aaaaacgctg atttctggga gaaagaatac actcatgaaa gtgaacgtgt ctcctgaaca 2503981 tactaaaacc ggcccgatat gacctcgtgc cggtttttta tgaacgatag tttgtataca 2504041 cttcttgaac atcatcgtca tcttcaagga cgtctattaa tgtttccagc ttctcaacag 2504101 cctgatcatc ggcttctgca taggtattgg gaagcatggt cacctccgcc gaagaaatta 2504161 gatatttcga ttcgagggct gttttcacct cttcaaaatg ctcaggctct gtgaaaacct 2504221 catataggtc ttcttcaatt cgcagctctt ctcctcctgc ttcaagcaca tcaagcatga 2504281 gctcatcttc ttctatttgc cgttcagtac ggtctatcgt aatgaacccc tttcgttcaa 2504341 ataaaaaggc tacacatccg ctttctccca gacttccgcc atttttatta aaggctgtcc 2504401 gcacatttga cgccgttcgg tttttattat ctgttacgca ttcaaccatg acggcaatcc 2504461 ctgaagggcc gtagccttca taggtgattt cttcatagct gcttccgtct tggcctcccg 2504521 cagctttttt aatggcccga tctatatttt cattcggcat attggcgcct tttgcttttt 2504581 cgatgacaag acgcaatgct gaatttgctt ctggatccgc tccgccttct ttcgctgcca 2504641 catagatttc ttttgccagc ttcataaata ttttcccgcg ctttgcatcc tgtgcatttt 2504701 ttcttttttg aatgtttttc cacttggaat ggcctgccat gttttcacct tcttttacat 2504761 tttctatgta cactttaatg ggaaatgttc gctgatgcaa agaaaaaggc tgccgaatat 2504821 cacttccggc agcccttcct tcctagcggt tgttcatttt atgaagtttt ctgaacagcc 2504881 ctttatctgt tgatacttgg acgtcacggc catttgcata gttgcgcgct gcttttacaa 2504941 cattatctct gtcagacttt gtgaactctc tgtggctttt gactgcgata actactcggt 2505001 catccgatac cataacttgt gtgtcattga cgtttttcac ttgtttcaca cggttggcaa 2505061 tttttgcagc cagtcttctg ttttcttggt tgtcataccc gttgttcgct gcattccgat 2505121 tcatgtttcg gttattcgtg ttgttatatg ttccgtcagt tgccaaagga acacgatcgt 2505181 cagcagtaac acggtcacgg ttatttacat tcgtggtgtt tcggttaccg tcgttctgat 2505241 cctccattaa ttcagaaaca ggaccatcgt ggtcgattcc gtctccctgt ctatcggcgt 2505301 cattttcatt tgtataatat ccgattggac gggtattgcc gttattgcgc gtatcattca 2505361 tagcattatc gtttgctccg catgctgtta agccggctgt cattagaatc aggctagcga 2505421 tcgtcatttt tttacccaat ggaaaaaccc cccgtggacg aattgagcat gtttgctcgc 2505481 ttttatcatg tgcgtatggg gggcatgtta agcgtgtcag ttctctccat ttggcagtga 2505541 tctgcttgaa aacaaaaaaa ggaacgattt acatcgttcc gaacgatcac tcattttctt 2505601 cttccggacg gccaaacatt tggtttacag aaggctggtt cgtcattggc atagaaactc 2505661 ctgccgaata tgggtttgga tttgggttag ctgtgccata tggcatatta gggcttccat 2505721 aagctcccat tcccgaatgg ccaggtgcag agaaatatgg ctgatgatca ccgtcacagc 2505781 cgcagtcgtc atgatctttg tatggcatgt aaccatgagc cgcagcaggc tggtatgctc 2505841 ccattacttg gggagtgccg taataagggc catacggcat atgtccatac ggagatccat 2505901 aagccggaga tgcgtattgc ggcgcaccgt atgaaccgta atgtccgtga tggctgtttt 2505961 catgatgctg gttttcataa cccgggtcat actgaggcga tacaaagcct ggctggtatc 2506021 catgcatcgg atgcattgga taagcttgtg ccggatagta cggatagcat aatcctgatc 2506081 ctggaagaat tggcgaaaca ggcaccggac acggtacgaa atgagccgga taatgataat 2506141 aaggctgaac agccggcatc ggcatattcg gaactgtgtg atgaacgttt tcctcttcta 2506201 taccgcctac ctctggcgcc tttggcatat taggcatatt cggataattt gcattttcca 2506261 tattactcat agcctcctgt tgtggaaatt ggtcttgcat atgatacata tgatccatat 2506321 ttccgtcatg atgttttttc ggctcctccg gtttaggagg cgaccaaggc tggaaaagct 2506381 gtttcatatc ataataatcg ttcacatcag cttcagggta cacattttcc tgcaaattag 2506441 gcatcggcgg gacatacggc atggacttct tttctttcgg ctttgtgtct tctacatcga 2506501 caacggattt aggcttctct ttcgcatatg gatgttcttg cttcacactc ccggccgcag 2506561 gacttttgcc cgcttttggc tcttttctga ccgggactcc ttctgacggc acttttattt 2506621 tcattccagg catgattaag tctggattgc taagctgtgt attgagtttt ttcacttcct 2506681 caacatcgac tccgtacttt tcagctattt tccagagcga atcgcctttt tgaacgatat 2506741 ggattttcaa cgttttcccc tcctatgcaa aacgtgaaca gttcagctgt gattacaata 2506801 tgtttcttca caacatatgc ctgaacaaaa gaagttatga gtaaaggaag ggaaaatatt 2506861 tctgatctac gtgatcgaaa gcattcgatt cagggcaagg agtgcatctt cctgaatggc 2506921 ttttggcacc ttgatgacgc ctgaaggttc tcctttttca atttgttcca gcgaccacaa 2506981 caaatgcggc aaatcaattc ggttcattgt caggcaaggg cacatgtcag ggttgagtga 2507041 ttcgatttgt ttatctggat gctcgtgaat gatccgctga acaagattca tttctgtccc 2507101 gattgcccac ttgcttcccg ccggagcctg gttgattgtg tcgataatat atttcgttga 2507161 tccgttatca tcgcttagtg tcacgacttc gtgtgaacat tccgggtgca caatgatctg 2507221 aatgtcgggg tctcgctctc tcatatcatg gatattttta gtggtgaatt tctcgtgaac 2507281 agagcaatgc cctttccaca aaatcacttt cacattcgta tgcccggatt cagctactaa 2507341 ttcatctttc atcggatccc acacagccat atcttcaagc gcaatgccca gatcataagc 2507401 cgtatttctc cctaaatgct gatcaggcaa aaataaaatt ctttttttct gtgtaaacgc 2507461 ccattcaagc acttttttcg cattcgaaga agttacagtt gctccgccat gctttccgac 2507521 gaatgccttg atctccgcag tggagttcac ataagttaaa ggtatgatcg tatctccaaa 2507581 tatatgctga agcttcttcc atgccctatt ggtctgctgc atgtcagcca tgtcagccat 2507641 agaacatcca gctctcatat ctggcaggac gaccgtttgc tgctcgcttg tcagcatatc 2507701 ggcggtttct gccataaagt gaacgccgca aaatacgata taatccgctt ctttgttttt 2507761 ttccgctact tgggccaatt gcagggagtc gcctgtttgg tcagcaaatt gtatcacttc 2507821 atccttttga taatgatggc ctggtataaa gagcctgctg ccgaactttt tcttaatggc 2507881 ggcaacgcgc gtttccatat cctttctcga tagttcttta taactttcgg gcatcatatc 2507941 attcgattgt ttgatcacat caagaattga cataacagca ttcctccaca gattcatttg 2508001 ataacgtaac atccatgctg atatctaaac ttttgacgga atgagtcaga aatcctaatg 2508061 aaatataatt cacacccgtc cctttaaaag caggcaaaga ttctaacgta atcccgccag 2508121 aggcttcagt ttttatatta gccggtgtga gctttgcaaa atgacggacc gtatcaggcg 2508181 gacagttgtc aaacataata acatccgctc cagctgcaat tgcttcccgc agctgttcct 2508241 ccgtttcaat ttccacctcg atatttacca tgtgccctgc ggcctgacgg gcttttttgc 2508301 acgcctctaa aatagagccg catgctgcga tatgattatc tttaatcatg atgccgtcat 2508361 acaaaccgaa tcgatgatta tacccgccgc cggctctgac agcatatttc tccagcattc 2508421 tgagccccgg tgttgttttt ctcgtgtcac aaattttaat ctgttcatca tccagacacc 2508481 gaacagcctc tcttgtcatt gtcgcaattc ctgacagcct ctgaataaga tttaatacga 2508541 cccgctctcc tgaaaggagc gcagctgcgg gaccgtgtaa ctcggcaatc acttcacctt 2508601 tatgcaacat gtccccatct tttttgtgta aaatgctttg aacattttcg tccaataacg 2508661 aaaagccttc ttttatgatc gctgctcctg caaaaatacc ctctgacttt gcaacaatct 2508721 ccgcttcaca gctctgttct ccaaaaatag actgcgatgt aagatcccct gtcccaatat 2508781 cctcaagaaa aaagtgattc agtaattttt tcagctgtaa atgattcatt gttccaaatc 2508841 ccctcgtttt ttctgatctt cgttcctttt tttgtatgga caatttgtct tccttgccag 2508901 ctcacctcag catgaggaaa atcggtgcgg aagtgagccc ctctgctttc ctcccgcaaa 2508961 agcgcagaaa acgtcatcag ctttgcagtt tgccatagat gagaaagttc catctgccga 2509021 attgtgatat ccttcacatt tacttcctga aaaggcagcg tatgaagcca gatgctaagc 2509081 tcaatcaaac tgctttgttc ccgcagaata gacatgtggc ttgtcatttt gctttgcagt 2509141 tcatgcccct ctatatccgg cacctcgtag aagacactgg tttctagccc tgattgatat 2509201 tgcctgttat aaaccggttt ttggataata tgctctgctg ccctttttcc aaataccagc 2509261 gcttccaata aagaattgct tgcaagccgg tttgctccat gtaaaccgga gcatgctgtc 2509321 tcgccaatcg cataaagccc cggcactgtc gtttctcccc agcgattaac tgaaacacct 2509381 cccattaaga aatgcattcc cggagcaaca ggaatttttc cgctgtggat atcaatccct 2509441 gctttttcac aaatagcggt gatggtaggg aaacgcgttt caaaatcaga aatcgcactg 2509501 aagtctatat aaacgcgatt tccttttgcc atttcttcgt gaataacccg tgagacaata 2509561 tctcttggag ccaggtcacc taaaggatgc cgttcagcca taatcctgcg gccgttttcg 2509621 tctactaaac atccgccttc ccctctgaca gcttctgaaa caagcccgta ggaaacacca 2509681 tttttcacaa gcagtgtcgg gtgaaactga gtaaactcca aatccgttaa ttccgccccg 2509741 gcccggtaag ccagagaaag accgtcacct gtgacagtga gatcattcgt atggtgaaga 2509801 aacaggtttc cacagccgcc ggcagccagc acaacttcgt ctgcgtgcct taccttgagc 2509861 cgccctttgc tgtcttttgt catgacgccg atacatcgtc cgtcctctat aagcaaatct 2509921 gctgccgttt cattctcgat taacttgatt ttgctgttga tccgtttgag caaataatcg 2509981 ataagcagcc tgcctgttgc gtctccgcct gcatgaaata tgcggttgta tgagtgggcc 2510041 ccttctcttc caagacaaac accgcctcgt tcattgcggt cgaatggaaa tccacgctcc 2510101 aataggcttt gaaccatcat ttttccatca tgtaatacgt ctgctacaat agctagatta 2510161 ttatggccgc accctgcgta taacgtatcc tccagatggg cttcaatcga gtcatctttt 2510221 gcataggccg cagcaatccc gccttgtgca tagacagaat tgctgttttt gacgcttttt 2510281 tttgtgataa cagtcacttc gtatgagggc gggaaagctg cagctaagga aagtgccgcc 2510341 gcccctgaac cgatgactgc aatcgtcttt ttagacatat gccatcctcc tgttgtttac 2510401 acctgtcttg acacctatat ttacacaagg ataaaataaa ctcaagagtt ttttatggag 2510461 aacggatgga ggaagaccgg atgatttatt tagattatgc agcgacaacg cctatttgtg 2510521 aggaagccct tactgtatat cagaagctta gtatggatat gtacggaaat gccagcagcc 2510581 tgcatgatgc aggaggaaaa gcaaagcaca tactggagta ctgccgtgaa aaaatcgcca 2510641 acatcattgg cggagaagca agcggcatct attttacaag cggcggcact gaatccaatt 2510701 ttctggccat tcaatcattg ttaaacggcc tgccaaaaac gaaaagacat tttattacga 2510761 ctgccatgga gcatcagtcc attcataatt gcgctgcttt tttggaacag cagggatatg 2510821 atgtaacagt cattgaaccg aatgaatacg ggcttattac cgaggaaata ttactaaccc 2510881 atatccggcc ggaaacaggc cttgtatcta ttcagcatgc aaattctgaa accgggatca 2510941 ttcagcccat tcaacacctg tcttcatacc tgcacaataa ggggattctt cttcattgcg 2511001 acgctgttca aacgtttgga aagatcccga tcaatacaaa aaatctggga gtagatgcac 2511061 tctcaatgtc cagccataaa atccacggtc ctaaaggagt aggggcggtc tatatccggc 2511121 cggatgtccc ttggaaaccc gtttatcctc tgactactca cgaatacgga ttcagagccg 2511181 gcaccgtaaa tgttcccggg atcggtgcct tcactgccgc tgcagaattg atcgtaagcg 2511241 aaatggaaaa acagatatcc cgcaatgagg cattaagaac atactttcta gaccaaatcc 2511301 gtattcggtc tctccctgta acccttgcag cagacacttc gaaagcagaa tgtcttccgc 2511361 atattatagg gtgttttttt cactcatttg aaggacaata tgttatgtta gaatgtaatc 2511421 ggagtaatat ttgcatttca accggcagcg cttgttctgc aggttaccac ggtccgtctg 2511481 aaacaatgaa agcattaaga aaaaccgaac aagaagctct gcaatttatc cgcatctctt 2511541 ttggcaggca tacaacagct gaacagctgg aacagttatt acatacgttt acagtgcttt 2511601 gggaacaaaa gaaaggagaa tttgatattg accgaagaat taaagctaat gggcgccaac 2511661 aggcgtgacc agcttcttct gtggctgaag gaatctaaat caccgctgac aggaggagaa 2511721 ctcgcaaaaa aagcgaacgt ctcaagacag gttattgtac aggatatatc gctcttgaaa 2511781 gcgaaaaatg taccgattat cgccacaagc caaggatatg tatacatgga tgcagccgct 2511841 cagcagcacc agcaggcaga aagaatcata gcatgtctgc acggtcctga acggacagaa 2511901 gaggaactgc agctcatcgt cgacgaaggc gttacagtaa aagacgtaaa aatcgagcat 2511961 cccgtatacg gagatttaac tgcagccatc caagtaggca cccggaaaga agttagccat 2512021 ttcatcaaaa aaatcaattc tacgaatgct gcctacttat cacagctgac cgacggcgtg 2512081 cacctgcata cactgacagc acctgatgaa catcgcatcg atcaagcctg ccaagccctc 2512141 gaagaagccg gcattttaat taaagactaa aaaaagccct ctagtgggct ttttttataa 2512201 ttggtaagac tggtatgcac ccagaagcct cactttgcag ccgagtgctt caagctcctg 2512261 catggcccct ggaatcaata catcatcaaa cgctttctca atatcaataa taaagaaata 2512321 atggcctaat ccggttttag tcggacgtga ctcaattttt gacaggttta aatttctcca 2512381 agaaaatgca gacagcactc tatgcagcgc cccggactga tcatcctgcg gcagcatgac 2512441 cattaaggtc gttttgggcc tagagctcaa ttttgaattc acttcaaaag atatgttttc 2512501 atcgggagac aggataacaa atcttgtatg attgtcccta taatcctgta tatcccgttt 2512561 cacgattttt aattcgtatg tagaagctgc catatcattg gcaatgaccc cgatattcag 2512621 ctcgggatgg tcactgacaa actttgctgc cgccccggta gaattggcgt attcatatgg 2512681 aacggaagga aaatgtcgat gaagaaattt atggcattgc gcaatcgcgt gtgaatgtga 2512741 gtaaattttg tcgagctctt tccatgcatt ctctcttgag ggatggacga gcaagtgctg 2512801 gtgaatcggc aacgtcattt cacccacgat tggcaaaggc tgttcatgta ttaaatagtc 2512861 tattgttaga ttaacagatc cttctaaagc attttccaaa ggaacaaaag caaaatcaac 2512921 ttcgcctgca acggctgcat ctatacactc cggaatggtg cggtaagcaa catgttcggc 2512981 gccgttttga aaacaagaac tgactgctag atgtgtaaat gtagctgctg gacctaaata 2513041 accgactttc atgacgattt tctctccctt atgcacctga acctaatatt tcaacctttt 2513101 ctacaaaatc aaacttcctg agcttattca ttaatgtatg aatgtcttct tccattgccg 2513161 acgtactgat agacagtgtc acatttgctc tgccttgaag cggaatggtc tggtgaatgg 2513221 aaagaacgtt gcttccagaa tcagctaccg cctgaagaag ctgagataac gcacctgacc 2513281 tatcctccaa atgaaagaaa agtgtgataa tttgttcttt taccatggtg tagaatggaa 2513341 aaacagcatc cctgtattta taaaacgcac ttctacttaa atcgaccttt tgaacggcat 2513401 ctgctactga atctgctttt tttcgatcaa gcagcttttt gacttctaat gtttttctca 2513461 ttgcatcggg caatacatct tcacggacaa gataaaatgt ctcctctttc atttgcatcc 2513521 cccctttaaa atagagagcc tggcaccagg ctctcttttc agccaacatt gattaatcaa 2513581 taaattcaaa ttcaaattcc agaagcctga ttatatctcc atccttggct ccgcgttctc 2513641 tgagtgcttc atcaacaccc attccgcgca tctgtcttgc aaaccgttta accgattcat 2513701 cacgtgagaa atcagtcatc ttgaataacc gctcaaggct gtctcctgaa agcacaaata 2513761 caccgtctgg atcgcgtgta atgttaaatg gcacttcttc attttccatc gtgtacatga 2513821 cacggttttg tgtaagctct tcctcgtcat acagcgggaa ttccggtgtg ttctcaagct 2513881 gattggcaac ctcaaacaga agctcacgca gaccttctct tgtcaccgca ctgatcggga 2513941 ataccggata atcatccgtc agcttttctt taaaggcttc gagattttcc gcagcctccg 2514001 gcatgtccat tttatttgca acgataattt gcggacgctc agtgagacgc agattgtact 2514061 cgctcagctc ctggttaatc gtaagataat catcatatgg atcacggcct tctaagcctg 2514121 acatgtcaat gacatgaaca ataaccctcg tccgttcaat atggcgcaaa aactggtggc 2514181 ccagtccgac gccttggtgt gcgccttcaa tcagccctgg caaatcagcc atgacaaagc 2514241 tgcgtccgtc atccgtttca accatgccga gattcgggac aagcgttgta aagtgatagt 2514301 ccgcaatttt cggttttgca gatgagacaa cagacagcaa agtagatttt cccacactcg 2514361 ggaacccgac aagtccgaca tctgcaagca cttttaattc aagaacaatg tagcgttctt 2514421 ttcccggctc gccgttttct gaaagctgag gcgcgggatt agccggtgta gcaaagcggc 2514481 tatttcctct tccgcctctt ccgcctcttg caatgacagc ccgctgtccg tgctctgtta 2514541 aatcagcgat gacctgtttt gtatcatcgt ctgtcacaac ggtgcccggc ggaactttaa 2514601 tgaccatatc atcagcattt cgcccgtgct ggtttttgga catgccatgc tcgccgcgaa 2514661 tcgctttaaa gtgttttttg tatctaaaat ccatcagggt gcggagacct tcatctactt 2514721 caaaaacgac gtctcctccc tttcctccgt caccgccggc agggccgcct ttcggcacat 2514781 atttttcacg gcgaaacgca accataccgt tgccgccgtc gccgcctttt acatatactt 2514841 tgacctgatc tacaaacata atgtcctccg ttctaaaccg ttaaaaactc cgctagtcca 2514901 acccaatttc aatcagacat tcgtgactcg tgatttcaaa acgcatgata tcaacgtcct 2514961 catatccatt ctgccgaata tcatcaaaag cagatggatc ggcaaaggcg ccgtgaaaat 2515021 caaggtacag aatcagctgt ctgtcaggat gatccgtttg aagcgaaacc gttaaatgat 2515081 tttcactctc tctgctgact gcttgatcaa acagatgaaa cagctttctc atcagtttcg 2515141 ccagcttttg atcataagcc gacaaatcct taatttctcc gagaacttca tattcaagcg 2515201 tcatataatg ggttttccaa ttaaacgtaa gaaaatcaaa cgccaaatgc ggtgttttca 2515261 ggtttgagag ctttgattcg tgctttgcgt ctataaccat ttcttcaatc atttcaaaga 2515321 cacggtcata cttctgtaag cttaagtttc ctttaatcag ctgcagctta ttcatccaat 2515381 catgccggga atggccaagc agatgaatca gttcgtttgt taatgccgtg tcgcttatat 2515441 tttcttcttg attttttgaa acatccttca ttttcgcact cccaatcatt taatttctta 2515501 tttaggagtc tgtataagtg tgtattatga attataacag agaaggcttt gttagaaaaa 2515561 caattgtttt tcccagaaat atcatgttcc ttttttctgg ctttggttga tttgcagcca 2515621 ggcagaacat tttatgtatt actgcttggg gaacatatcc agtgggtttg agatgtttat 2515681 tctcattctt ggcggggtct gctcgcacat actctgcatt tcattctagg tgtttactcc 2515741 gcatattgca aaaaaaactc cagtcatcat cgaccggagt tttttgaatc attattgagc 2515801 tacaggatat acgctcactt ttttgcggtc acggccgaaa cgttcgaatt taacagttcc 2515861 gtcgattttc gcaaatagag tgtcatctcc gccgcggccc acgttttcac ctgggtaaat 2515921 ttttgttccg cgttgacggt aaaggataga accgcctgtt acgaattgac cgtcagcacg 2515981 tttagcacct aaacgtttag cctcagagtc acgtccgttc tttgtagaac ctactccttt 2516041 tttagaagcg aaaaactgaa gatctaatct aagcatgtag ctcacctcct atattatgtt 2516101 tgtggtcaca cgcaagttgt ctttgtaatc ccgttcgatt gtctccagcg aaacaatcat 2516161 gccttcaatc agcagctgag ctttttggcg tgcctctgga tcaagagatt cagggaattc 2516221 aaaataaaaa taacccccgt cctctcctat atcaagaagc ggctcgaagc ccgcgagcac 2516281 aatgaccgcg ttaacggccc caaacacaac ggctgtcact ccggcacaaa caagatcttg 2516341 tccatgttca gcaaaattcg catggcccgt catttcaaaa gacaatatgc ctttatcatg 2516401 agaccttctg attgttgcct gaatcatgct tacgcgttga ttttttcgat cgtcacttta 2516461 gtgtaaggct gacgatgacc ttgtttttta tgaacgtttt tctttggttt gtatctgaaa 2516521 acagtgattt ttttcgcgcg gccttgtttt tcaactttag ccgttactgt tgcgccttca 2516581 actgtagggt tgccgacttt cacgttgtct ccgccaacaa acaaaacgtc ttcaaaagta 2516641 actgtttcac ctgcttcagc agcaagtttt tcgatgtaaa cagtttggcc ttcttcaact 2516701 ttgatttgtt taccgcctgt tttaatgatt gcgtacattc tctgcacctc ctattagact 2516761 aagactcgcc agataccagg gggctgtaaa agctcttaac acctgtactg agcggttgta 2516821 gcaatggtgc tacatccata acattaaaaa atataccaaa atacaaggcg tttgtcaatc 2516881 agttttagta gggcagaagc agttcctcca tggaagaatt cgtccgctta tcggcaaagt 2516941 aagcgtgcag cacttcattc tcgtcaagct ggctgagctt ttggcctgat ttttctataa 2517001 taatcggatg cttacagcca cgtttgaact cggccatcac atgatagact ttatcctccg 2517061 cctttactgt cagcggcaga agtttctcaa gctccctgtt ttttccgtaa tacctttcga 2517121 ggagaaatct cacatggata tagtgccttt gccgatattc ctcaaacaag gaaacagcca 2517181 gaaagacaaa caaaacccat gcgctgattt gcagaggaat cacgaataaa acccagcacc 2517241 cgagcagcag gcagaagcag agcgacgttt ttagattaag ccggtgagcc ttttgaaaag 2517301 gcagctgttt ggaaaacaac aaaaataaca gttttcctcc atccagcggc cagatcggca 2517361 gtaaattgac aaataagata gaaagattat aaaaggtgaa gagttcaaag gtatgctgat 2517421 gaatcactga gacttctgca agcatccagg cggcaaactg aagccagatg tgctgaagag 2517481 gtccggcaat aatgaccgca aactcttcct ttaacggccg attcccgtgc tcttccactt 2517541 cgaccgttcc gccaaacggc agcaaaaaaa cacgcttgat tctccaagaa aaaaacacag 2517601 ccagagcagc atgccccagc tcatgaatca atacaatcag gagcagacat aataatgctt 2517661 tcatatggcc tgtgagcaag cccagcgccg caataatcca aagaaaagga tgcacatgga 2517721 tctttaagat aaggtcgagc catttattca aatgaaatca cctgaatcgg atcaataaat 2517781 ttatcgccgt ctttcatggc aaaataatag acccctttat tatgatcatc aagcttaatc 2517841 gaaccgagct ttttgccttt atccacaaaa tcatataaag caacatccac atctttgagc 2517901 tcgccataga tactataggt gttgtcagca tgctgcacct taaccgtcag tcccgtttgg 2517961 ctgtctttgc tgacttcaac cacatagcct tcttttacgc tatcaatctt atcactgctt 2518021 gtttcgactt taattccttc cccattgtcc tgaaaatcct gctgtacttt cccggatgca 2518081 ggcgcgatca gatctttgcc tacttcaatc tgctgttcct tatttttgtg ttcaggagcc 2518141 aggaaagcaa gcggatttcc gaatttggtt tcgaaccaat ggcttgctga agcaaattga 2518201 aattcagttt caaaggtttt ggctacggcg ggtttaatct gactgacggg tccaatgttt 2518261 gttttatagg ctatagctga aacgagaaca aggcaggccg acagaagaca tttcaggata 2518321 attgaatctg ttttcaccaa tgggtgtttt ccgttgaatg ttggcatgtt atcttcgtag 2518381 accggaagtg ttccatgctt ttcctgatcc gttaccatca cccaggacgg gggtttctgc 2518441 ttttcagaaa ctgtctgagt agagaaacgt tttgagccgg aaagctgctt tcttcttttc 2518501 tctaatcgtt ttctgatttc atctgctctg tgactcattg ccatcatcct ttgcattcgt 2518561 tgggtttgta catcatatgt cttgtccatg gcaaatattc ggtttagtca agaacaaagc 2518621 aggcaaaaac aaaaaaaacc tgacacagca tatgctttgt cagattcttc tctttgattc 2518681 tatcacatta agatcttact ccgaaaaatg acttaatctt agccatcatt cctttgtttt 2518741 gctcttcaag cacctgtaaa ggaacagatt cacctaagat gcggcgggca atattgcgat 2518801 atgcaatgga agcgcggttt ttagggtcca tcgcaatcgg ttcgccatga ttggaagctt 2518861 taatgacttc atcatcatca gccacgattc cgagcaaatc gatcgacaga tgctgtacga 2518921 tttcgtcgat atccatcgtg tcaccgtttt tcatcaggtg atttctgatt ctgttaacaa 2518981 cgagccgcgg cggttcaata ttttcctctt gctccagcag tcctataata cggtcagcat 2519041 cacgaacagc tgagatttca ggcgtagtga ccacaatcgc tttatcagct ccggaaacgg 2519101 catttttgta cccttgctcg attccggcag gacagtctat gatgacatag tcaaattcct 2519161 gtttgagctc ttggaccatg tttttaattt gttcaggagc aacagctgtc ttatcgctcg 2519221 tttgagcagc gggcattaaa tagagcagat catcgaaacg tttgtctttt acgagcgcct 2519281 gatgcatttt gcatctgccc tctacaacgt ctaccagatc gtaaataatt ctattttcaa 2519341 gacccattac aacatcaagg ttgcgcagtc ctatatcagt atctactaag catacgcgct 2519401 tccctaaaat ggctaaggcg gtaccgaggt tcgcagatgt tgttgtctta cctactccgc 2519461 cttttcccga agttattacg atagcctcac ccaattcaca ttcctccctc aagccttgtt 2519521 agatcaggtc ttaaatgagc caaatgttga aggcgttcaa tgaccatatt tccgtctgta 2519581 tctaaataag cacattccat ttcgttccct ttttgaatgt ggtctgggga gcgatttaac 2519641 acatgattga ttcttaattg tgtcggaagc atttcagagg cggcgatgac cgcttgatta 2519701 tttccattga atccagcatg cgcaattcct ttcagtgagc ccagaacaaa aatgttccct 2519761 ccggccctga ctgttccgcc gggattcacg tcaccgatca ggagcaagtc gccttttacc 2519821 tgcagcactt ggcctgaacg gacaattttt gaaacagaaa taatttcggc ttcctctctt 2519881 atctgctgtg cttctttttt agtaatgact tcactgtcaa tagaatgaac aaacaaatct 2519941 ttctttgacg caatcaattc ggttagctgt tcctcttgct ccttatataa aaagcgattt 2520001 cccagcttaa catgaacgct gattttctgg ccttttccat cggtatattg ttcaattgac 2520061 agcatattct gaagaccatc gagaagctca tcaaaagaac acgcatcatc cagatgcaat 2520121 gttagtccat tctttgttcc ttttattgtt acatattgct gctttttggt cttcacaata 2520181 ttcacctcaa caacatactc atttcgtcaa aaaaagataa aatccttttt actcatctct 2520241 caattctttc tttagactca taaaaaacaa tctaaatggc agaacaagaa taagagctgc 2520301 tgcaatattt aataaaattg tcggtataaa ccggtcaagc acaaatccgt taaacgtcat 2520361 aatgtcttta tgaatcaaag actgaatgcc gaatacgtaa aattcgagca gacagacagc 2520421 cagaactgct atcaatatca ctacaaatgc gtttgtatgc aacactttaa acgcttttga 2520481 agccaaatag catagccctg caaaaccaaa catgtaaacg cctaatagac ttgtatagtt 2520541 catgtcatat agaaagccaa aaataaatcc gtaaatcatc gcgtgttttt ggttgataaa 2520601 agccgacatg aatatcaata caagcatcaa aaaacgcggg gcgagcactt ggtcatctgt 2520661 aacgaaagga aaatgcacca aatctgtaaa aatgctttcc gcagaaaaaa caagcatcat 2520721 aacgaaaggg agaaggaaac gtttcacgat ccttcctcct ctgtatcgac agtcggcacg 2520781 tcacggttaa caacgatcac attatttaaa tctgtaaggt cagccgcagg ttttacataa 2520841 gcaaccttcg ttaatccata ggaatctgac tcgatatcag tcacttcacc gattgtcagc 2520901 ccttctggga aaacaccgcc tgtccctgat gtttcaataa gatcgccttt tttcacgtct 2520961 tgtttatcct tacgctcaat aattgtcatc ttaagacgtt ttttctcttt gtcatatcct 2521021 tcgatcaagc cgtagccttt gctgcctttt tttccggaaa tttttgtcgc gactctgtta 2521081 ttgcggtcag tatcgcttaa aagctgaaca gcagacgtaa aattgttaag tccggagctt 2521141 ttgatcttgc cgattaatgc gcctttttcg tttgtaacgg ccatatcttt cgctacgttt 2521201 tgctgagtcc ccttgttaat ggtgacctgt ttcgcccaat tatcagggct tctggcgatg 2521261 accgttgcta aaatcggctt gtaatcttta atcgatttga catggccaag ctcgtcacgc 2521321 aaggatttgt tttcttcttc aagctcttga agcttggctt catattgtgt ctgtccgtca 2521381 agtttttctc ttagacgctc gttttctttg tatgtgtttt ttaaatcatt gatgttctca 2521441 aatattcctg caaaaaattc ggcaggcgta tgaaaaatat tttgaaatac tcccgtcgta 2521501 tcgccgatca ctttctcagg ccaggtggta ttgcggccgc ccttcagcga aaatccaatc 2521561 atagccacca atatgataat acacagaagt aatagcatta accgcttatt cggcatcgtg 2521621 ttacacctct tctattgaac tcccgattat ctagttttcc ctttgaaaag atggatgtgc 2521681 tccagtgctt tccctgttcc gatcgctaca caatcaagcg gatcttcggc gataaggacc 2521741 ggcatttttg tttcttcgct gatgactttg tccaaattgc gcaaaagcgc tccgccgccg 2521801 gttaacacta tacctctgtc catgatatct gctgcaagct caggcggtgt tttttcgagt 2521861 gtgctcttca ctgcttcgac aattgtagat acagtgtcgc gtagagcgtt agaaatctct 2521921 tttcctgtaa tttcaattgt tttcggcaaa cctgtgagca aatcgcggcc gcggatttcc 2521981 atgttgtcgg attcttcagg agcttctgca gatccgattt ccattttaat cgcttcagcc 2522041 gtacggtcac cgatcatcag attgtacgtt tttctgatgt agttgataat cgcgtcatcc 2522101 atctcatcac cggctacacg gattgactga gacgttacga tgcctccgag ggaaataatc 2522161 gcaacttctg tcgtaccgcc cccgatatca acaaccatgc ttccagtcgg ttcccaaact 2522221 ggcagattgg ctccgattgc tgcggcaaaa ggctcttcaa tcggatacgc gtcacgcgct 2522281 cccgcctgtc ttgtcgcatc gataacagcg cgttcttcaa cagctgtaat gcctgatggg 2522341 acacatacca ttacatatgg ttttctggca aacatgcctt tattttttat ggcctgattg 2522401 atgtaatatt tcatcatcgt cgccgttgtt tcataatcag cgataacgcc gtctttcatc 2522461 gggcgaagag ccaccacgtt gcccggtgtc cgtccaatca tatttttcgc atcatttccg 2522521 acagcgacaa tcgatttcgt atccgtctgc aaagcgacaa ctgacggctc tctcacaaca 2522581 attccttttc cttttacaaa aacaagcgta ttcgcagttc caagatctat accaaggtct 2522641 ctagcaccaa ttccaaacat atgtatgtat cttcctttct taaagcaaaa ataccctaaa 2522701 gggaaaaact cataaactct attatagctt aattcgacga aaaaaaaagt gttacaaata 2522761 tcctttttcc tttaaactca caaatttttt atccccgatc accaaatggt caagcagctc 2522821 gatgccaatc aggtttccgc attcaaacag ccgtcttgtc acttcaatat cttccctgct 2522881 cggcgtcgga tctccagaag gatgattatg aacacagata aaggaagcgg cagatcgttt 2522941 aaacgcttct ttaaacacct ctcgcgggtg gacaatagat gaattcaggc ttccgataaa 2523001 tacggtgcgt ttatggatga cttgattttt tgtatttaag tataaacaga caaaatgctc 2523061 ctgggttaaa aagcgcatat cctccatgac aagattagcg ccgtcttccg gggagcgaat 2523121 aacgaaatgt tcttcgttgg ctaatttatg aatccggctt ccaagctcaa ctgctgccag 2523181 tatttgaatc gcttttacca taccgattcc cgggatgctt gacagctctt caaccgatgc 2523241 ttccttgagc aggcgcagcc cgtcaaatga gcgcagcagc cggtttgaca ggtccaaaac 2523301 agattcgtgt ttagtccctg tccgcaataa tatagccaaa agttcatgat tcgctaagtt 2523361 ctcggctccg actttcagga gccgttccct tggcttttct ttcattggga aatctttgag 2523421 ttttaatggc agatcgtgta tgaccaagca ctccttttct ttcccttccc gtttatagaa 2523481 ccgtcatgcc cttatatcaa aatggcgaag agctctcatt gtttttgata taggaaggcc 2523541 catgactgaa taataatctc cgtctatttt ctttacaaaa agcgcgcctc ttccttggat 2523601 gccgtatgca cctgctttat ccatcggctc ttttgtttca atatatgtcc aaatctcttc 2523661 ttcactgagg gaccaaaacg caacttctgt cttatcataa aaagtctcgc tgtgattttc 2523721 agcttgaatg ctgaccgcgg ttattactga gtgacttcgg cctgaaagcc tccgcagcat 2523781 agaagcagct tcttcttgat cctgcggttt gccaagacat tcgccgtcaa ggcataccat 2523841 tgtatcagca ccgataacga ttgcatgcgg gtggagatca gctacagcct tagctttttg 2523901 ttttgccaac cattggacgt tttcttctgg tgaaaagttt cgatttaatt tttcttctac 2523961 ttcactgaca ataatggagt agggcagctg gagaagatcg aggagttctt tcctgcgcgg 2524021 agattgtgat gcaagtatta gcggttttgt catgttcgtc atcctttcag ggtttgctta 2524081 agaaaaaaag atactcgttt atcctaccaa atcacgaggc ttgtcacaat ttcagaaaaa 2524141 taactttttc atgacaaaat aaaaaaagcc tgtcactaaa ggacgaaggc tcagggcact 2524201 atctcttatt ttacgacggc taacagctcc tgctgagcct tccacccggc ttcagcactt 2524261 ggatcctcta attcctttaa agcctgcaaa atcgcttttt tctctcctgt ttctgacgct 2524321 tttgtttcac caagcgactt ttctattttc tctacactcg cttttgtaat gtcttcgtcg 2524381 agaatcgcct ttgctgcaag ctccgctgtt tccttaaaag aatctgtcat atctgactct 2524441 attgataagg aaagctcctt gcctccccag gcttcaaaat cactgtcgat taaaacctgt 2524501 cctaactgct gtgagacctc cttttcactt gctaagcctg caataacata cgtatacccg 2524561 tcatcctttg acagtgacac ggcggaatat cctttttcgg tcaattgttc tgttaacgtt 2524621 tcggcgccct tttcatttga aaattttccg gcttgcacag cgtatgtttt gtatgtacct 2524681 tcagtttgtg ccgcttgttt ttctgcgcct gaggtttgtt tatcagcaga agtatcccct 2524741 gcttttgccg tttggctgcc taaagaatcc tctaaagagg ccggtgctga cgcttcttta 2524801 ttccccgata tgtttaacgc gaataaccct aatccagtgc caatgacagc cgcgaaggca 2524861 atcgtcgcgg ccactctttt taccggtttg gcagccccgg tctttccttt tgcgtaaagc 2524921 tttgtttttt tcttttgaaa aggaggaaca actttagggt cctctttaaa caccttgtcc 2524981 tcctcggaat cccaattgaa ttcatcttca tcagggtgtt cctgggatgc cgcaacctct 2525041 tgttctgcct gtcttttttc ctcccaattt gaaaatgtca tgcttttatt cgcctctgtc 2525101 tcaggcgtct cttgttcgta aaccgtctct tcttttccat taatcgtcac cttgagggct 2525161 ttttctgcgg ctttactgtt ttttttattc tttctttttt tcaattccgc ttcctccctt 2525221 catttgcttg accgttcttg tcggcttttc atgctacaca ctttagcaca ggcaaagaaa 2525281 aaaagaacaa gacttttgtc gccttgtcca aaaaacgttc gtcaaatttt tcagcagtca 2525341 gcccaatgcc attttgatat aaaaagaaat gatagagtca ccgtataaat aggctaaaat 2525401 gctccctgcg gctatagcgg gggcgaaggg aagcggctgc cttttagcga gtctaccagt 2525461 cagaacagct gccgctccat ataatgcacc tatcaaaact gaaaagaaaa aggcagctgc 2525521 cagcattttc acaccaagca caaagccaat caccgcaaat aatttaatat ctcctccccc 2525581 tactccccca tgggtgattg cggcaattac agccagaaac aaaaatccgg ctgccgcacc 2525641 taacaggcct gcataccagg aatcaagcgg agaaatcaat ctcgcggccg ccaaaaaggg 2525701 aagaaagaaa atcaatattc gatttggaat cagcataaaa tgaatatctg tcactgcaac 2525761 aataatgaga agagagataa acaccacagc gggaaacagt tccagcgata tgccaaagcg 2525821 tattcctgcg gcggcaaata aacacgctgt cacaagctct gctgcgggat acataaaaga 2525881 aatcctatgc ccgcagcttt tacatttacc tttttgaaat aggaatgaca ggatgggaat 2525941 taattctgca ggagttaatg ttcgccggca aaacgggcat gatgaacggg gcgcaataat 2526001 agatagatgt aaggggatac ggcacccggc cgtatagtaa aaagaaccaa ggataagccc 2526061 gaagataaaa agaatggata gcatagacaa cacaccttta ctcattgagt tctggtatgg 2526121 attgtagcaa aatggacatc ctgagctcca attgggaata ttcaatttta cacatgaaaa 2526181 aaacggcaga atcttttttt gattctgccg gagccggatg cttttatttc aacctttttc 2526241 gaatgtcaga aataaagtaa agagatccgg taatcagcac aatttcattt gagccctttt 2526301 tactttctat gaatttgatt acatcgtctg gatcttcact ccagctttta ttgctgattt 2526361 cacttgcatc atagagatct tttgcaaggg aagcacgcgg gaaatcaaaa gaagcaaaat 2526421 gaatcgcatg agcaatggtt tccagtcttt taatcatgtt ctgatacggt ttgtccttta 2526481 acgcgctaaa caccacagaa atgcgtgaat tggcgaaacg ctgcttcatc gtttccgcca 2526541 gcttttcaac accttcttcg ttatgcgcac cgtctaaata taccggagga tgttcctgaa 2526601 caagctctaa ccgtcccggc caagcagcct tcacaagccc gctccttaac gcttcgtcac 2526661 tgatatgggc gatattctcc ttattgagcc actccgcagc caaaatggac aaagcagcat 2526721 tttgtctttg atgggtgcca atcagagatg tccgaatatc ttcatagcat ttctcttccg 2526781 ttttgaatga aaactgttct cctgcaggca gagcctcttc attgaaaata acacatgcat 2526841 catgcaatga ctggaacggc gcagcatgcc gttcggcttc atggcggatg acctgtaaag 2526901 cttccggctg ggtaactgct gtaacgattg gaataccttc tttaataatg ccggcctttt 2526961 ctcctgcaat ttcttcaatg gtgtttccca aaatgttcat atgatcgtgt ccgatgcttg 2527021 taatcacagt taagagcggt tcaaccacat tagtagaatc gaatctaccg cccagacctg 2527081 tttcaaaaat aacaaaatcg accttatgaa actctgcaaa atataaaaat gcacaagctg 2527141 tcataatttc aaattctgtc ggctgtccgt attccgtttg atcaagggct tcaacgtgcg 2527201 gtttcatttg attgacgagt gctgtccatt cctcatctga aatcggtatc ccgtttacgc 2527261 tgatccgttc attaaacgta ataatataag gcgatgtaaa tgttccaacc gtatatccgg 2527321 cttcctgcag catagaacgg ataaaagcga cagttgatcc tttaccgttt gttcctgcga 2527381 cgtggaacgc tcggattttt ttttcaggat gtcctaaccg cgccatcagc tgtttcattc 2527441 gaccaagtcc gggcttcacc ccgaatttca gcctcccgtg aatccagctg cgcgcatctt 2527501 gatatgcagt aaacaatgat aatcccctct tttataagac aaggcggttt ctctagaaac 2527561 cgccccggct tttcattaac ccttcagctc agccattcgt ttttgaacag cgtcacgctt 2527621 cgccacataa tctttttctt tttcacgttc ttcatcaatt acgtgtgcag gcgctttttt 2527681 cataaatcct tcatttccaa gtttcttttg gacacgctca acttcttttg tcagtttatc 2527741 aaattctttt tgcagacggg caatttcttc atcaatattg attaagcctt caagcggaag 2527801 aataacctct gctcctgaga caacggccgt catcgcctta tcaacagcct caatatcggt 2527861 gccgatttta agcacgctcg gattcgtaaa gcgttcaaca tatgaacggt tcgcttcgag 2527921 gcgggacgct atttcgtctg tgcttgtttt aatgtacagt tcaacctgct tgctcattgg 2527981 cgtattgact tcactgcgga tattgcgcac agaacggatc agctcaacaa gaagcttcat 2528041 gtcagctgcc gcttcagtat cggtatgctc cggcactact gcaggccatt gacttactgt 2528101 aatcgattcc ccttggtgag gaaggtgctg ccaaatttcc tccgttaaga atggcataaa 2528161 cggatggagc agacgcatcg tttgatcaag tacgtaagca aggatggaac gggtagtttt 2528221 cttagccgct tcgtcttctc cataaagcgg aagcttcgcc atttcaatat accaatcaca 2528281 gaaatcatcc caaataaagt tatataaatg gcgtcctact tcaccaaatt catatcggtc 2528341 agcaagctgg gtcacgtgct cgatcgtttc atttaatcgc gttaaaatcc acttgtcagc 2528401 gactgacttt tcacctgaca gatcaagctc atcgtacgtc atgccatcca tattcattaa 2528461 tgcaaaacgg gaggcgttcc aaattttatt ggcaaaattc caggtcgatt ccactttttc 2528521 atagctgaag cgcagatcct ggccaggaga gcttccagtc gcaaggaaat aacgcagaga 2528581 atcggctccg tacttgtcaa tcacatccat cgggtcgaca ccgttgccaa gagatttact 2528641 cattttccgg ccttgctcgt cacggattaa gccgtggatt aaaacatctt tgaacgggcg 2528701 ctcgcctgta aattcaatgc cttggaaaat catgcgtgat acccagaaga aaatgatatc 2528761 gtaccctgtc acgagaacat ctgtcggata gtagcgttta aagtcttcag ccgttacatc 2528821 aggccagccc attgtggaga aaggccatag cgcagaactg aaccatgtat ccagtacgtc 2528881 tgtatcctgt tcccaatttt cgctgtcttc cggcgcttca agtccgacat atagctcgcc 2528941 tgtttcttta tgataccagg caggaatacg atggccccac cacaattgac gggagataca 2529001 ccagtcgcgg atattttcca tccagtgtaa atacgttttt tcgaaacggt caggcacaaa 2529061 gttgaccttt tcttcttttt tttgcagctc aatcgctgca tcagcaagcg gctgcatgcg 2529121 cacaaaccat tgtgtagaaa gataaggctc cacaacagcc ccgcttcgtt cactatggcc 2529181 gacagagtgc atatgatcct cgatcttgaa gagaactccc gcctcctgta aatctttcac 2529241 gagctttttg cggcattcaa aacgatccat accttgatat tggagcgcat tttcattcat 2529301 cgtgccatct tcattcatga caaggatgcg ttctaaattg tggcggttgc caagctcgaa 2529361 gtcgttcgga tcatgagcag gcgtaatttt cacggcacct gaaccaaatt ccatatcaac 2529421 atagtcatca ccgacaatcg gaatttcacg atttacaatc ggcaggatca ccgtttttcc 2529481 gataaggtgt ttatagcgct cgtcttcagg gtgaacggca acagctgtat caccgagcat 2529541 tgtttcagga cgtgtcgtcg caatttcaat tgagcctgaa ccgtcagcaa gcggatagct 2529601 catatgatag aatgcgcctt gaacatcctt gtaaatcacc tcaatgtcgg atagggctgt 2529661 ttttgtcgct gggtcccagt taataatata ttcgcctctg tagatcaggc ctttttcata 2529721 aagcttaacg aatacttccc ttaccgcttt gctcaagcct tcatccagcg taaaacgttc 2529781 acgggaataa tctaggccaa gacctaattt cgcccactgg ctgcgaataa agtcagcata 2529841 ttcttccttc cacttccacg tttcttcgag gaatttttca cggcctaaat cgtagcggga 2529901 tttgccttct tcacgaagtt tcgcctccac tttagcctgt gtcgcgatgc cggcgtggtc 2529961 catgccagga agccacagca catcatagcc ctgcatgcgt ttcattcttg ttacaatgtc 2530021 ttgcagcgtt gtgtcccatg cgtggccaag gtgaagtctc cctgttacgt ttggcggcgg 2530081 gatgacaaca gagtatggct cttttgtctg gtcactgccc gcttcaaaaa atttgccttt 2530141 tagccaaaaa tcatatcggt ctttttcaac cgctgccgga tcatatttcg tcggcattgt 2530201 ttgttcattc gtttccatca taaccctcca gcatgtttaa aaatggctga gaacgaaaaa 2530261 agagctcttc atccctgtaa aaggacgaaa agctctttcg cggtaccacc ttttttcatg 2530321 aactcaatca gttcatgcac ttataacgga taacgggtgt ttcccgaatt tctctactct 2530381 tctttcaaga aattatgctc ccgggcgacc ttccaatcag acaacataag aagcctttca 2530441 gcaaacggct tctctctctg catgcgcctt ttttgtactc ttcccgttct aagcaggtgt 2530501 atttatcagc tcattgtata cattatttat gttctttatt atagtaaaag tgtttttgat 2530561 tcgtcaatca tcttttccaa aaacaccgct ttctatacag atgggcaggc acctattgcc 2530621 caagtttaca tatgatgctt gtaaatgcgt agaggaggat gcaccgtgaa gaaacgtttc 2530681 agctcttatt cgctgccgcc atgggtaagg caaattcggc ttgtatccgc acaagtgatt 2530741 attcccatta cgatttttca aggaatcaga accattttct ttccgacaac ctttgatgtt 2530801 ttgctgctcg caatcctaat ctttttagct tgcgcccttc atttagaatg gatataaaca 2530861 aacaagtccg cgccattaag acgtggactc gttttcagcc tgaaattttt tctcttgttc 2530921 aatctgatga attttcatca caaacggctc tatgtttttc atttgccaat aagcctttaa 2530981 taattgtgta cattcctctt tttcatgctg tcttttccca gtttgataac cgttcagcac 2531041 cttgtacatg gctgccggat atgccatata gctgagaaaa aggctgactt ccgcttcacg 2531101 caaagggaat gatttcgtat atccataaaa ccattcgacg cattccggac aagctttcgg 2531161 aaagcctctg aacatttttg tataaaagcc gagcaggtcg ttttgcggcg gaccgacaga 2531221 tgctctttcg aagtttgtaa aatatccggt cccggcatca ttatacagaa aatggtgtat 2531281 agacaggctg ccgtggttca ttacaaccct tgaaacgtcc ttttcctttg cggactcata 2531341 ccagtcctcc agccgttcca gcgcaaagtt caccgcggaa atggtttcag aaaaataggt 2531401 tatggcctgg agttcaaagg gagaaaggta ccattccttc tccgctctat ccacaaactg 2531461 ctcatagaaa attttatctt gttcccactt ttttttcgtt tgcccgtaat aacgttcaat 2531521 ctcatcacgt ctaaccttta gttcctgcgc ggttctctcg tgaagacggg ctgtttctct 2531581 aaataaataa gcatgttttt gatcccgttc ttcctcttgg tcaaattgga gccaaggcat 2531641 taaatagtag atatctccgt attgtatgcc tgctgagaaa aactcaccgc tatttgttct 2531701 gtaaacggga acgaatgaac gaaagccttt ttcctcaatc gccaccatat gatctgtaaa 2531761 atgcttgccg cgaccttctt tcaatttttt cagggcaaat atgccgtagt ctgtatacac 2531821 tttccaaaca agaggactga caggctcaat aaattgagca gtcagtccgt attcctgaag 2531881 aaccgattgg gtatcttcca tttcattcac cacattttcc gatcacttac ggtttacgca 2531941 tggctatttt tatattgagg aatatagaga atctgtcctg cttttaattc atcatccaag 2532001 gctaaagaat tcatcctgat cagctgctgg gatgtaattt cataccgttc gcataaacgc 2532061 tcgatcgtat cttcctgctg cacaatacaa attttcattc tcgaaaactc atccgcttct 2532121 tttgtaaaga gttttgttaa ataaagagaa ttatcacttt cctttgtttg aggttccttc 2532181 gtttcagcag caggagcaac cctaggaaca gcatccgttt ccttcctttc agtctcagaa 2532241 gattcaggca gctggaagga ttgaaaaggt gtttcttcct taggctcttc agctgatggt 2532301 gtttttctca cttcaatttc gaagctctct tcctcttgtt cttcctcctc cagcagctta 2532361 ggcgctgaat aaaaagaatc ctcctcttct tgttcaggca ggaaggtacg gtatgccggt 2532421 tcaggcaatt cttcttgaga tgcctcctcc gagcttgttt tttgattgaa atggaaatgt 2532481 aaatcggcat tgtcattctc catatataca gctgaagctg tttctctgct atcttctatg 2532541 gagagagcgg cctctgatac actctccaaa gcttcatccg gttccgcctc ttcttggcaa 2532601 agcgcaggat cagcctgatc cgattgagct gcttcttcat tttgagcctc ttggcgcagc 2532661 gcatattcat gattaggaga cactgttgtt tcctcttttt cctttgcaat cacagtctct 2532721 gaatgaagct cagcttccaa agcaggcgat tcttctgctc caacgtgttc acgaagctca 2532781 gtctccgctg gagagtctgc ttcttcacga acatccgcta ttgcagctgc cggctctgcc 2532841 gtttcttttt ttgctttaac gatctcttga atctctattt ctgaaggatc aggttctggc 2532901 tcagattctt ctgtttccga ttcagcacga acctccgttt ccggcacagc aagctcttct 2532961 gactcttctt cctctttcac atcttctctg gcctctggtt ctgaagcaac cgattcaggc 2533021 ggctcagatt ctgctttttc tgtctccagt tcttcacgga gccccgcttt cgagataaaa 2533081 agttctggcg gttcggctgg cggttcatgc tgaagaactg cttcctctgc cgatgatgca 2533141 cccggttctt ctactacact atgtgccggc ggctctgaaa gctcttcctc cctgaatgcc 2533201 gcaggagctt catataaagg tatctccggc tctttgtctt gcgtatcgtc caaaagccct 2533261 tcgatcgcta aatcagcttg aattgttaaa atgcgcgaat ccgtcaattg atagtcaaat 2533321 gcgtcaataa agacgaagac atcctgtaaa tggctcactt tatttttcgg aatggtaata 2533381 tccacaggaa aacagtgagt cagttccgca cttccatcct ctctctttct gacttgttca 2533441 acaaaccgct tatctgtata aatctcttcg gtatgtttgt tttgatctat gttgtactca 2533501 cctgtaagtt caagcgatcc tatgattgat acataatcat ttacttcctg aaccctaata 2533561 tcaggatcta atgaaataga aagcagttca gaaacttcct gtcctttttg gaaacagatc 2533621 gattcttcta cagaaaattg caatcgatga ttttgcggca agttcatatc ctcctttcat 2533681 ctaatcctta aaattagatg tcactaaagg tgtatgtatg aactggagaa aatatgagtg 2533741 ggagagcacg aaaaaaccgg cacaaggagt ccttgatacc ggttttcact cttatctgcg 2533801 gctgatctca gcaaatactt tctcagctgc ctggattgtg ttttcaatat cttcatcagt 2533861 atgggccgtt gagaggaaaa gaccttcgaa ttgtgatggc ggaaggaata ccccttcatt 2533921 tgccatccct ttataatagc ttgcgaacag cttcaaatca gatgatttcg ctgtttcata 2533981 attgatgact ggttcgtttg taaagaagaa accgatcatc gaacctgcac ggttaaaggt 2534041 atgcggaatg ccatgagccc cggcggtttt tgaaattcct tcttccagtc tgtcgccttt 2534101 tttgatgaaa ttcttgtagg attcaggtgt cagctgtttc aatgtctcta agccagccgt 2534161 catcgcaagc gggttgcctg acaatgtacc agcttgatag atcggaccgc ttggagcgat 2534221 ctgctccatg atttctgcct ttccgccata agcgccgaca ggaagtccgc ccccgattac 2534281 ttttcctaaa caagtcagat caggcgttac gccgaagtag ccttgagcgc agttataatc 2534341 gacccggaag ccagtcatca cttcatcaaa aatcagcagg gagccgtact gctcagtgat 2534401 atcacgcaga ccctgaagga aaccttcttg cggcggaaca acacccatat ttccggcaac 2534461 tggctctaca atgactcccg caatgtcttc accgaattgc tggaaagcaa gctttacact 2534521 ttctaaatca ttgtacggaa cggtgatggt gtttttcgca atgccttcag gcacccccgg 2534581 gctgtcaggc agaccgagag tggcaacacc tgaaccagct ttaatcaaga gagaatcgcc 2534641 gtgtccgtgg tagcagccct caaattttaa aatcttgttg cggcccgtat agccccttgc 2534701 caaacggagg gcactcattg tagcctctgt tccggagctt accattcgta caatttctac 2534761 agatggcaca cgatcaatga cgagcttagc cagttcattt tctacttcag tcggagcacc 2534821 aaagcttgtc ccgtattcag ccactttttt gaggctttct acgacgcggt catttgtatg 2534881 ccctaaaatt aaaggccccc atgacaagac gtagtcaata tattcattcc cgtcaatatc 2534941 aaagattttc gagccttttc cgcgctccat aaaaatcggg tccatgtcta ccgatttaaa 2535001 tgcgcgaacg ggactgttca caccgcccgg catgagtttt tgcgcttctt taaaagccgt 2535061 ttttgatttt tcatagcttc tcatctgcct caactcctgt caactgaata aaattactcc 2535121 gcaagccatt tcgctgcgtc tttcgcatga tacgtaataa tcaggtcggc acccgcgcgc 2535181 ttcatgcttg tcaaaatttc caacacaatt tctttttctt tgatccagcc gttctgcgct 2535241 gcagccttca ccattgaata ctctccgctt acattataag cgacgagcgg caaagtaaac 2535301 tcatttttta cgtcacgcat gatatccata taagaaagcg aaggtttgac aatcaaaaag 2535361 tccgcgcctt cctcaacatc tgattgtgct tcgcggagtg cctccatacg gttggcaggg 2535421 tccatctgat atgttttgcg gtctccgaat tgcggtgtgc tgtttgctgc atcacggaac 2535481 ggaccgtaaa actcacttga atatttaaca gcgtaagaca tgatgggaat attgacgaat 2535541 ccttctttat caagtgcttc tctgatcact gtaacaaatc cgtccatcat gtttgatggc 2535601 gcaatgatat ccgcacctgc tttcgcttgg ctgacagctg tctgcgccaa aagctccagc 2535661 gattcatcat tgagaatgac tccgtctttg acaagtccgc aatggccgtg gtctgtatat 2535721 tcgcacaggc acgtgtcagc gacaacaacc atttcaggga agtgttcttt aatttctgtg 2535781 atggcttttt ggacaattcc gtgatcatgg tacgcttgtg ttccgcaatc atctttttct 2535841 tccgggatgc cgaacacgat aacagattga atgcccagtt tgaccagctc cgctacttca 2535901 tccttcaata aatctaatga tacatggtga acatcaggca ttgacggaac agcttttttg 2535961 ccttccagcc cttcaacgac aaaaatcgga tatataaaat ctgatggatg caaacgtgtt 2536021 tcctttacca tttctctcat tgcttttgat gtccgcaggc ggcggtgtct attaaatgat 2536081 tgactcatat tctctcttcc tctcttgaca tgctgcacat taactcaagc atgccatcta 2536141 ttgtaaatgt atcaggcgta tgcgatgtga tgccgtacgt cagaagggca tcatttgtta 2536201 aaggcccaat gctgatacag gccgtcccat tcgccttcca cttttttaat tcttctccca 2536261 agacatgcat aaacgtatgt acggttgatg aactcgtaaa tgttacatag tcaaaggaat 2536321 attgacccgc agcgtctttc aatgcctcaa tgccttcttc atccggaatc gtttcgtaga 2536381 gaacccattc ctttacttca aaaccgagcg ggacaagctc ttgttttatc acatcacgtg 2536441 acaaattccc tttcatcacg gtaatggtct cccccggttc agcatgctgc ttaagagcgt 2536501 cagccaattg ttcagcaata tactcctgtg gcatcacatc aaccgatacg ttatgcattt 2536561 ttaaacggcg cgcggttttt tcaccgacgg ctgcaatttt tttatgcgca gggagaataa 2536621 gctgattttc cttcagataa gaaaaaaaga agtctgcccc gttcacactt gtaaaaacaa 2536681 gccagcctgg cgcggcaaga tcctctctta cctgttccgc aacatcattc ggcaaagcgc 2536741 ggcgaaacgt aatcaaagag gttaaaaccg ctttaccgcc aagcgcctcc actttttgct 2536801 gaaatgatgc tgcctgtgcc ttattccggg tgacaagcac tgtttttcct ttcaacggaa 2536861 aatcattttc catcctcgtc aagctcccgt tttacacgat caattaaatc ttttgctcct 2536921 ttgtcagcca taagagcggc acagcgcttt cctacttcct ccggatcgtt tccggtgacg 2536981 gtttctttaa aaatgatttt gccgtcaggt gaagcgacaa gacctgtcat ttcaatttca 2537041 tcctgtccat ttaacacgga gtagcccgcg atcggaacct ggcagccgcc ctccatcgcg 2537101 tttaaaaaag cacgttccgc taagacagtc cgttttgtat attcatctgt aaactgagaa 2537161 aacaacgcca acagctcttc atccgattct cggcactcaa tcgccagggc tccctgcccc 2537221 acagcaggca aacagcgctc aggctcaagg aattcggtta cgacatcttg cttccaaccc 2537281 attctggaaa ggccggcagc cgctaaaata attgcgtcat aatcctctgt ttccagcttt 2537341 tgaagtcttg tatctatatt acctctaatc catttaattg taaggtcagg gcgctcaatc 2537401 aaaagctgcg cgcttcttct taaactgctt gtgccaatga cagcaccttt cttcatttct 2537461 gaaagcttta cgcgattctt tgaaataagg gcatcacgcg ggtcctcccg ttcaggaata 2537521 cagccgatca caaggccttc aggcaaaaca gcaggcatgt ccttcatgct gtgcactgcc 2537581 atatcaatct cttcgtttaa aagcgcctgt tcaatttctt tgacaaaaag cccttttcca 2537641 cccacttttg agagtgtaac atcgacaatc cggtcgccct ttgtcacgat ctctttaatt 2537701 tcaaaagcaa acgaaggatt gatttccttc agtttttgaa taacccattt tgtttgagtc 2537761 atagcgagtt tgctccgtct ggaacctact ttaatcgttc tcatcatttc tttcctcccg 2537821 aatctgcttg ggacatcgtt taactgaacc aatggaattg cgacaggctt ccaagcagga 2537881 aataattgat catcagcacc agaaaacaag ccgtattcca cagtgcagcg acctttcctt 2537941 gcagctcctt aatcagcctg atataaagat aatagctgta cagcagcagg acgacaaacg 2538001 aaccaagcac tttggcgtca aaccaataca gcgtttctag tgagacatac gcccaaatga 2538061 cgccgagaat caaactcagc agcagcatcg gaaccccaat gacatttaaa acatacgcca 2538121 tataatcaag cttagataaa tcttctattc tcaacagcca ttttccccac tttttctttt 2538181 tcagcagatg atattgaaac atatatagca cagaaaaaac gaaagaaagg gaaaaagcgc 2538241 cgtatgaaag aatcgccatt gtaatatgaa tcaccaaaag ctcggataca agctgcccgg 2538301 aaaaagcagc tgactgctgc tctgtcggtg aaaatgtgtg aatggcgatc atagaaaatc 2538361 ctataacatt tgtaaaaaac acgataaagt caacacgtaa aagctttgtc agtacaagtg 2538421 acagcgtgac aagcacccag gcataaaaat aaagtgcctc tgtcacattt aataccggaa 2538481 accgccccgt cacccacata aaataggcca aatacacggt ttgcagagtc cagacaatag 2538541 aaagcaacca gaaggccatt tttccagcct tccggttgtg ttgaagaaaa tctataaaat 2538601 aaaagagtac acttaacgcg taaatgacga ttgtcccctc attaagtctt gccattgcag 2538661 tatcaatcat tcagctttca ctcacttaca agtgggctaa agcccgcttt tgattcagcc 2538721 ttcttaaaag agtggacctt ctggctgctt tcaacggttt tcatcatttg acggcccgca 2538781 gcttcttcaa tatcaaaaat ctgcataaac aacgcgagct tttcttcaga atcagcatct 2538841 gccgcaagct ctttcacctt taaaatcgga tcacgaagca tttggttaat aatacttttg 2538901 gtgtgtttgt tcaacagttt tttctctctt gtgcttaagt gaggcagctt acgctcaatg 2538961 ctgtccatcg tttctgactg gatggcaagc gccttttcgc gcaatgcaga aataacaggc 2539021 acaacaccaa gtgtattcat ccattgttta aattccacaa tggtttcttc aattaacagt 2539081 tcaacttttt cagctgtttc tctccgctct ttcatgttcg cttctacaat gccttccaga 2539141 tcgtcgatat cataaagaaa aacaccttca agatcattca gcgccggatc aagatctcta 2539201 ggcacggcaa tgtcgaccat aaacagcgga cgtcccttgc gaagcttatt cgcgttttcc 2539261 atcatctctt tggacacgac aaattcactt gcaccggttg aactgattaa aatatcagcc 2539321 tccgcaagcg cgctttcaag ctgattcaag cttctcgctt cacctgaaaa acggtctgca 2539381 agctccttcg ctttcaagta tgttcggtta atgacagtga ccttgccgat tccctgtccg 2539441 tgcaggtttt ccgcagcaag ctcgcccatt tttcccgcac cgagaatcaa tatgtgcttg 2539501 cttgaaagat ttccgaagat ttttttggca agttcaactg cagcatagct tactgacacc 2539561 gcatttgagc caatgtctgt ttcggcgtga gtccgtttgc ccactgtaac tgcctgctta 2539621 aacagctcat taaaaatagt cccgatcgtt ttttcttgct gagctgtttt aaagctgtcg 2539681 cgtacctgtc cgagaatctg cgtttcgcca atcaccatag aatcaagtcc gcaggctaca 2539741 cggaataaat gctcaacagc ggcatcgctc tcataaaacg ttaagaacgg tgacagctct 2539801 tctttgctta attgaaacca atcagctaaa aactttttta tataataacg gccggtatga 2539861 agctggtcga ctaccgcata aatttcagtg cggttgcagg ttgagacaat gatgttttca 2539921 agaatgcttt tctcttcttt cagctgcacc attgcttctg ccagctcatt cggctgaaaa 2539981 cttacttttt cacgtatctc aataggggcg gatttataat ctactcccac aacaagtata 2540041 tgcatcgctc taattacacc cccaacaccc aatcttaatt tataatcatt ctaacataga 2540101 actcattatt tataataatt ataacatagt ttctttcaca aaatgtgaac agattttaaa 2540161 attcttatgc tatattagaa aaagcttcag ggaaaagaag cattcctatt gacaatacca 2540221 aaaacagcag aaatttacta cacatcagct ctaaaaaaca agaaggtgat atgcatgaaa 2540281 caaaaatcaa ttttattccc ttgtctgctg cttgccgctt ctgtatatgc atggctagaa 2540341 agcggccaag ccgaactgtt ttcagggcag gatcaatggc ctgttctcct catgctgtta 2540401 ggcgcagcct ttgtatatca aggaaaaaaa gaagccgtca caccccattt ttttatcggt 2540461 ttgcttctct tcgggatcgg tttacacttt tttgccaagc cgaaatgggt atggtggccg 2540521 gatgattttg aaatgctcct ctttatgatc ggcttctcac ttctcgtttc aaccgttcaa 2540581 aaaaaagaat atgtatatga agctgtgtcg atgatttgtt tttccctgtt tttgtacttt 2540641 ttcaaacaaa ttatggcatg gcttgagtct gcgcatattc caacagcgct tctgaaggag 2540701 tattggccgt ttgtctttat tggaatcagt ttattgttat tattgataaa acgaaaaaaa 2540761 tctatacgat aaataaaacc ggtagaggat cctctaccgg tttatcattt ttttgatcgc 2540821 tccccaagct tcgtcttttc cctttttcgt ttctgaagaa aagaggatca gctcgtcttc 2540881 cggatcaata tttaatgttt gtcggacaac cttcgcgtgt ttgtcccatt tacctttcgg 2540941 gatcttatcc gcctttgtag cgataacaat aacaggaatg ccgtaatact ttaaaaattc 2541001 atacatctgt acatcatcat tagatggcgc atgccgcaaa tcaacgatct gcaccacagc 2541061 ttttaattcc tcgcgtgtcg tgatataggt ttcaatcatt ctgccccatg cttcacgctc 2541121 agactttgac actttggcaa aaccgtagcc cggcacatcc acaaaatgca gctcatcatt 2541181 gataatgtag aaattaagcg tttgtgtttt tcccggcttt gatgacgttc tcgcaagatt 2541241 tttgcgattg attaatgaat tgataaaaga cgattttcct acgttcgatc ttccggccaa 2541301 tgcgatttcc ggaagccccc cttcagggta ctgttccggt tttactgcac tgatcacgat 2541361 ttctgacttt gtgactttca tttcttctct cctactaagg catgttccaa aacctcgtct 2541421 aagtgggacg ccaatataaa tgtcagcccc tccctgacgc tttccggaat atcctctata 2541481 tctttttcat tatctttagg cgcaataatg gtcgttaatc ccgctctatg tgcgccaagc 2541541 gctttttcct ttaagccgcc gatcggcagc acgcgcccgc gaagcgtgat ttccccagtc 2541601 atgccgactt cacgcgaaac cgcccgtccc gttaaagcag aaacaagcgc tgttgccatc 2541661 gtaataccgg ctgacggacc atcttttggc accgcaccct ctggtacatg tatatgaata 2541721 tcatacttct catgaaagtc aggttcaatg ccaagttctt ctgttttgga tcgcacatag 2541781 ctgaatgcag cctgagcaga ctctctcata acatctccga gctttcctgt caggattaat 2541841 ttcccttttc ccggtgaaag cgatacttca atcgaaagcg tatctccgcc aacggttgta 2541901 tacgcaagcc ctgtcactac accaacttga tcctctgttt cagcttgtcc atatctgaaa 2541961 atgcgttttc cgataaaatc ttgaaggttc ttctcagtaa ccgtaattcg ttttcgctct 2542021 tcagcaacaa tggcttttgc agctttacgg caaattgcgg caagctggcg ttcaaggctt 2542081 cttacacccg cttctctcgt atagtaacga ataatatcaa gaatcgcctg atcacgcagc 2542141 tgaagattgc ttttcttcag cccgtgttct ttgatttgct ttggaagcaa gtgatccttt 2542201 acaatttcaa gtttttctat ttctgtgtag cctgcgatat taataatttc cattctgtct 2542261 ctgagcgggc ccgggattgt ggccaaattg ttcgccgttg cgataaacag cactttggat 2542321 aaatcaaagg tttcttcaat atagtgatca ctgaagctgc tgttttgctc tggatcaagc 2542381 acttcaagca tagcggatga tgggtctcct ctaaaatcag atgacatttt gtcaatttcg 2542441 tctaataaga agaccggatt cagcttgccc gcttttttca tcccttgaat aatacgtcca 2542501 ggcattgctc cgacataggt ccgtctgtgt ccgcgtatct ctgattcatc ccgaactcct 2542561 ccgagtgaga ttctgacgaa tttgcgtccc aagctttttg caattgattt ggctaaagac 2542621 gtttttccga cacctggagg tcctgccaaa cagagaatcg ggcctttcag ggattttgtc 2542681 agcttctgga cagccaaata ttctaaaata cgttctttta ctttttcaag cccgtggtgc 2542741 tcttcgtcca agagacgtcc tgcttctttc aaatcaagct tatcatctgt ttcatccgtc 2542801 cacggaagag caaccagcca gtcgatatag ttgcggatca cagagctttc cgcagaactt 2542861 gacggaattt tttcatatct gttcaattct ttaagcgctg tttctttcac atgatcaggc 2542921 atgcctgctt cttcgatttt ttccgtcagc gtctgaactt cgccagtttt gccttcttta 2542981 tcgccaagct ctttttggat cgccttcatt tgttcacgca agtagtattc cttctgcgta 2543041 cgctccatcg aacgtttgac gcgctggccg atttttttct caatctccag cacttctttt 2543101 tcattattaa taaaatcaat gaccttgttc agcctgtctt tgacatcagc cgtttctaaa 2543161 atatcctgct tatcctttag tttaaggggc agatgagaag caacgatgtc tgccattctc 2543221 cccggctctt cgatatcagt aaccgcagcg tacgtttcgg ccgagatttt tttagaaatt 2543281 tttatgtact gatcaaagtg gtctagcaaa gtccgcatca atgcttcgtc ttctgtatct 2543341 tttgaatcat cttcatgaat aagttgaatg tcaaccgacg tgtaatcctc gtgttcattg 2543401 tatttgacga tatgggcgcg cttgaggccc tccaccaaca cacgaatcgt accgttcgga 2543461 agcttcagca tttgcttaat ttttgtatag gtgccgacag tgaaaatctc gtcttcacca 2543521 ggttcgtcta tcgaaatatc ctgctgagtg gctaaaaata tcatatgatc atgcatcatt 2543581 gcctgttcaa gagcctgaac cgacttgtca cgtcctacat ctaaatgcaa aaccatcgtc 2543641 gggtacacta ataaacctct taaagggagg agcgggatgc tgcgttttaa ttcttctgcc 2543701 atgtgactga cacctccgtg actttagtat gaaccattat aatacaactt tttcatcctt 2543761 gtacaataaa cggcatggtt ccattttcta taaaacagtc tcctcgtagt ataccctttc 2543821 tttctgatat gaaaaaggaa aagatgtcct tcatgaaaaa aaccctatta tcaaaatagg 2543881 gtttaaacgg attctttatt gatttcgata tgaaacggtt tttgttccgt tggcggattc 2543941 accaaaattt catcaagcac ttcttggaac gtcttcactg caataatctc gatcccgtca 2544001 atctgcttta agatggcctg ctgattttca tatgggataa tcaccttttt cgcaccggac 2544061 tgcttggccg cttttatttt cggaatgacg cctccgatgg gtttcacaag accgttcagg 2544121 ctgatttcgc ccgtcatcgc aacggtattg tcaataggaa ttttgtgtat cgccgagaaa 2544181 atccccgccg ccatcgcaat gcctgctgac ggcccatcaa tcggaatccc tcctgggaaa 2544241 ttgatgtgaa tatcataatc agaaggcttc attcccattg tccggagcac ggttaataca 2544301 ttttcaaccg aacccttcgc catgcttttt cgcctgatcg attttgattg gctgccgatg 2544361 ctttcttctt cagctattcc tgtgatgtta attgatcctt tatcttgagc cgcggttaca 2544421 cttacttcga tttccagaag cgatccgctg ttaggcccat agactgcaag cccatttaca 2544481 atgccaacct gtggttcaac accgattttt tgctcgtgct ttggagtaag ctgactggag 2544541 tgaatgaccc attcaatatc ctcaatcgta atgtcctttc gattctccgt tacagccatc 2544601 cccgctgcga tttgaatcat attgacggct tcccgcccgt tccgcgtgta gctggtcaaa 2544661 agatccagtc cttcttcgga gatatttttt tcaattttat ccgctgctgt tttggcaacc 2544721 gttttcagct cgtccttttc aagctcgcgg aaaaaaacct ccaaacagcg ggaccggata 2544781 gctggcggaa tttcgtttgg cattctcgtg gtcgcgccaa tcaagcgaaa atcagccggc 2544841 agcccatttt gaaaaatatc atgaatatga ttcggaattt gtgtattttc ctcactgtaa 2544901 tacgcactgt ctaaaaagac ttttctgtcc tcaagcacct tcagcatttt attcatttga 2544961 ataggatgca gctcccctat ttcatcaata aacagcacac cgccatgggc atgggtgaca 2545021 gctccctgct tcggctgcgg aatcccagcc tgtcccatcg ctccggcccc ttggtatatc 2545081 gggtcatgga cagagccgat gagcggatcg gcaattcctc tttcatcaaa acgggctgtt 2545141 gtcgcatcga gttccacaaa gacagcctgc tctttaaacg gtgattgttt atgttttttt 2545201 gcttcttcca acacaagccg cgcagcagcc gttttcccaa ctcccggtgg cccatagaca 2545261 atcacatgct gaggatttgg cccgcataaa gccgccttta atgctttaat gccgtcttcc 2545321 tgtccgacga tatctttaaa gcttttgggg cggaccttct cagataatgg ctcggacaag 2545381 ctgatagcgc gcattttccg aagctgctcc atttccttct ttgattcttt atctatcgtg 2545441 accttttgtg tcctttgatt tttaagcaaa ttccaaaaat acaaaccgat gatgatccca 2545501 aaaaacagct gaataaataa cgcgatccct gtccaactca tggtggtccc tcctgaaaaa 2545561 caatttatgt atccaattca ttcctctgat tgctagtatc tcccatagaa gacgggaata 2545621 aacgtttttc cggaagagtt gcatgcaaaa aaacctcctg agtgttacca ctcaggaggt 2545681 ttgtgcttat ctttatgcag atgttttatc ttggcttacc tcagtgccgt cttttaataa 2545741 gaggcgagga ggctctccgt gtgtcacagt tgccccggtg attacacatt tttcaatgtc 2545801 atcacgagaa ggcagctcaa acatcacatc aagcatgatg ccttcaatga tagaacggag 2545861 tccgcgtgct ccagtcttgc gttcaattgc ttttttagca atttcagaaa gcgcttcttc 2545921 ttcaaactca agctcaacgt tgtcaagctc aagcattttc ttgaattgct taacaagagc 2545981 gtttttcggt tttgttaaga tcgcaaccaa tgcttcttcg tcaagctttt caaggcttgc 2546041 aataaccgga agacgtccga taaattcagg aattaacccg aaacggagca aatcttctgg 2546101 aagcactttt gaaagaagat cttctttctc aagatcagca gctttattgt cggcaccgaa 2546161 tccaatcact ttttggccta aacggcgttt gatgatttgt tcgataccat cgaaagctcc 2546221 gccgcaaatg aacaaaatat ttgttgtgtc aatttgaatg aattcttgat gaggatgctt 2546281 acgtccacct tgaggcggta cgcttgccac tgtaccctca agaattttaa gcaatgcctg 2546341 ctgtacaccc tcacctgaca catcacgtgt gatagacggg ttttcagatt ttctagccac 2546401 tttatcgatt tcatcaatat agataatgcc tttttcggct ttttccacat cataatcagc 2546461 agcttggatg agcttcaaga gaatattctc tacatcttca cccacgtatc cagcttcagt 2546521 caaagatgta gcgtccgcaa tcgcaaacgg cacatttaaa atgcgagcca atgtttgcgc 2546581 cagaagggtt ttaccgcttc ccgtagggcc gattaatgaa atattacttt ttgaaagctc 2546641 aacatcatca actttgctgt tggagttaat gcgcttatag tggttataca cagcaacagc 2546701 aagtgatttc ttcgcttgat cttggccgat gacatattca ttcaaaattt cgcgaatttc 2546761 ctgaggcttt ggtacgtctt taaattctac ttcttcttct gttccgagtt cttcctctac 2546821 aatttcagtg cagagttcga tacattcgtc acatatatat acaccaggtc cagctacaag 2546881 cttacgaacc tgatcttgtg tttttccaca gaacgagcat tttaattgtc ctttttcctc 2546941 gttaaattta aacattcttt caccccttaa tcttgtctca ctttttcttt taccggcaga 2547001 gcaaaagaaa atgattcttg aaacgaacga gtatgtattg cattttacca tactttccaa 2547061 aaagacggta acaatgtgtt tctgacttgc acattctata tgtatgacaa aaaacagccc 2547121 tgcattaact atattgcccc aagaaaaaga gataactcat aattgtacaa aacaaggcac 2547181 gaatgattcg cgccctgttt tattagtact attattatgc accatattaa cggttttcta 2547241 caagaaaatc aattgctttg cgaactttta aatcttcttt catcgcgtca gtagaaccga 2547301 tggcttgttt aatattttca acaggcatgt tgtatgcttc agccattttt gtaagctcag 2547361 catcaacttc ctcatctgat acttcaaggt tttccgcttt cgcaatcgcc tcaagagtca 2547421 ggttagattt tacgcgtttt tcagcatctt ctttcatttg ctctttaagc gcagcttcat 2547481 cttggcctga gaattgagtg taaagctcaa ggttcatgcc ttgcatttgc agacgctgtt 2547541 cgaattcttt cagcatgcgg tcaagctcag tgtcgaccat tgcttgaggc acatcgattt 2547601 cagcattttc agaagctttc agaacaagct cttcacgcaa tttagcgtca gcttcgtttt 2547661 cttttgcttc ttctaaacgt ttctttgttt tttcagttaa ttcagcaagt gtttccactt 2547721 cttcatcgat atcttttgcg aattcatcgt caagctcagg aagctctttc gctttgattt 2547781 cgtgaatttt cactttaaac acagctggtt tgcctgcaag atcttcagcg tggtactcct 2547841 cagggaatgt cacttcaaca tccttctcag cacctgcttc aaggccaact aattgatctt 2547901 cgaagccagg gatgaatgaa ccagaaccta cttctagaga gtagttttca gcttttccgc 2547961 cttcgaaagc ttcgccgtca acgaatcctt cgaaatcaag aacaactgtg tttccttctt 2548021 caacggcgcc ttcttctttt acaacaagct cagcttgacg ctcttgaagg gcttttagtt 2548081 cgttttgaac atcttcgtca gttacagttg tgtcgtcttt ttcaatgccc aggcctttgt 2548141 attcgccaag cttcacttca ggttttactg ttactttcgc agtgaagatt aagctttcgc 2548201 ctttttcgat tttttcaaca tcgatttcag gacggtctac aggctcgatt ccagcttctt 2548261 caaccgcttt agggtattct acaggaagaa gaatatccaa agcatcttgg taaagagctt 2548321 ctacgccaaa gcgctgttcg aataatccgc gaggaatttt acctttacgg aatccaggaa 2548381 ttgaaacttg ttttactact tttttaaatg catcatcaag tgctgtttta aacgtttcag 2548441 catcaacttc aaccgttaaa acgccttcgt tgccttcttg tttttcccat tttacagaca 2548501 tgtgtttccc tccaaaaatc tattcaggtt gtgtcggtct tccattctaa agcaatcatt 2548561 cggcttcgtc caacaaaaac aaagctgcca aagatcagaa tcattatgta tagatgttaa 2548621 taatgaactg caaagcctgt ccaaccgtat ttcttataac ccgttataca caaatacaac 2548681 cactatatta taacataaca catagcgctt tcaactatat ggcgcgattt acaaataaga 2548741 aatttcttca atatctttta acattgtgca agcttcatcg agttctctgt ctgtaaattc 2548801 atacatcata tgaagttctt cgctttcaat ttcaatcccg tgcatctcgt aaccgacttt 2548861 atgaagggca gccgcccaaa ggtcagccga cagcaatttc ggctggaacg gatataaaac 2548921 gtacaaatgt cttctccaca attcttctac tgctgcatat aaggttggat tttcatttcc 2548981 aagtgtctca tctagcaccc tgagaacacg gtgaagaatc ggcgcggcat caggcggaac 2549041 aatctctgac ggttcaattg tcaacgactc gccaaattta ctaatgtgta caggtttact 2549101 gtactcatgc tcagccaaca gcatgacaat catcgttttg ataatcggat gggctgaggg 2549161 gtcttggagg attgttttga gcaatcctgt atactttgct acgttacggt cttttaagga 2549221 atgaatgaga ttcatttgct cctcagggct tgccagcact ttctcggtgt caattgtatc 2549281 ctcatattct tcggcccaag cctcgtcctc acgatccgga tcggtcattt tccggctgaa 2549341 atccagcagc ttataaaatt gctcggcact ttctgccggc agctgatttt cttccaaaac 2549401 ggcttcaatg gtgcttttga cttcttcgta ctttttgagc tgaattaaga tggtcatgta 2549461 cacctgcaaa accgtaaaat aatggccata accttctttg agcatcttct cgcacacgct 2549521 ttctgcctct tccagctcgc ccagctctaa aaagcagatg gccatcccta agtgaagatc 2549581 ggattcagta tcatcatatt tcatcgcttc tgaaaacagt tcaagcgctt cttgatactt 2549641 tttttccttg agtgatgaca tccctttttc cacaaggcgg tctttcagat gaggaaaagg 2549701 aataattttt gcgtttttct tgtcatgcgt catacctata ttcctttcag gcatttattt 2549761 tgttcaagtg tatcaacacc tgtgaacaaa aacaagaaat gaaaggtttc accaggcaaa 2549821 aaaagccgcc ggacaaatac cggccgcttt ttcaggcttg aagccaagag cttctttgtg 2549881 attcaaattg cttgatttca tcttccagca gcagcgttaa tgaaatttca tcatatccgt 2549941 tgatcagcat ctctttccaa tgcggatcaa cttcaaatga aatttgattg ccttcactgt 2550001 catgaatcag ctgattttca aggtcaacag tcatttgcaa tgactggttt tcatactggc 2550061 cgacaagctg tttccaattg tcatatggca tgcggatcgg aagcatgccg tttttaaagc 2550121 agttctgatg gaaaatatca gcgaatgacg gcgcaatgat aattttaaac ccataatcat 2550181 caagtgccca cggagcgtgt tcacgcgatg acccgcagcc gaagttttct cctgctatta 2550241 aaatggaagc tccttgataa acaggctggt ttaattcaaa ttcagggttc ggttcaccat 2550301 tcgcatcata tctccagtca aagaatgcaa aacgtccgta gcctgttctt tcaatcctct 2550361 tcaaaaattg cttaggaata atctggtctg tatccacatt gatccgattt aatacggctg 2550421 ctttccccgt atgtgatttc aaaggttcca tctcgcgcac tccttacaca actgtttttt 2550481 cctgataaaa ctttctgaca tcaacgaagt gtccgtgaat ggcagccatc gcagccattg 2550541 ccgggctgac gagatgtgtt cttgcacctt ttccttgtct gccctcgaag ttgcggttag 2550601 aggttgatgc acagcgctct ccctcaggaa caacatcatt attcatactc aaacacatgc 2550661 tgcagcctga ctctctccat tcaaatccag cttccaagaa aatctggtca agcccttctt 2550721 tttcagcctg aagcttcacg ctttgggatc cgggcacgac gatggccctt acgctgtcag 2550781 ctaccttctt ccctttgatc atgtcagcag cctgtcgaag gtcagtcatg cgggaatttg 2550841 tgcaggaacc gataaatacg tgctccactt taatgtcttc aattttttgg tgaggagtca 2550901 atcccatata ttcataagca cgaatcgctt cttttttatc gtcttctgca gaaaagcttt 2550961 ccggcgcagg aacttcagaa tcgacaggaa gaaccattcc cgggttaatg ccccatgtca 2551021 ccatagggga aattttgttg ccgtcaagga cgatagattt atcgtaaaca gcgcccgggt 2551081 ctgtgcgcag cgccttccat tcctctacgg ccttgtcaaa ttcttcgcct tttggcgtgt 2551141 acttgcgatt tttgcaatat tcaaacgtca cctcgtcagg tgcaatcaaa cctgctcttg 2551201 ctcctgcttc aattgacatg ttacaaacag tcattcgttc atccatcgtc atatttctga 2551261 atacttcccc agtgtattca atgacgtagc ctgtgccgaa tttcacaccg tatttgccga 2551321 tgacagcaag gatgacatcc tttgccgtta cccctttttg aagcgttcca tctacgcgca 2551381 cttcaagtgt ttttggacgc tgctgccaaa gtgtctgtgt ggaaaggaca tgttcaactt 2551441 cactcgtccc gattccaaat gcaagagcgc cgaaagcgcc atgtgttgat gtatgactgt 2551501 caccgcacac aatcgttttc cctggaagcg ttaagcctag ttcaggtccg acgacatgga 2551561 caatcccttg atccacactg tgaagatcgg caaggcgcac gccaaattcc tcacagtttc 2551621 tttcaagcgc cgttacctgg cgtttcgcaa cttcatcctt tatctcaaaa cgattgacag 2551681 tcgggatgtt gtggtccatt gtcgcaaatg tgttttgggg tcttctgacc tttcttccct 2551741 tttgtctcaa gccttcaaat gcctgaggag acgtcacctc atgaatgagg tgcaaatcaa 2551801 tatagagaag atccggcttt ccctcaccat gttttacaat atgctgatcc caaatctttt 2551861 cgatgattgt tcgaggcatc atcttttatt tcctccctct acctagagct aagaccgctt 2551921 aacgtaagct gtcacacatt agaaattgta ttttcactca tgattgctgc cttaacttcc 2551981 tctgtaatgg cctgagtgct gctgaactct tcactccgtg ccaagtctct tgttcttttt 2552041 ccagaagcca agactttgtt taccgcatct tctacagctt tcgcttcctc ttcaagcccg 2552101 aaagatgttc tcaaaagcat tgccgctgac aatatggctg cgaacggatt tgccatccct 2552161 ttaccggcaa tatcaggcgc ggagccatga acaggttcaa acagatgaag gccagagctt 2552221 gataggctgg ctgacgggag cattccgagc gagcctgtaa gcatggacgc ttcatcgctt 2552281 aaaatatcac cgaacatatt ttcagtcacc acgacatcaa attgattcgg tgcataaatt 2552341 agctgcatgg ccgcgttatc cacaagcatg tgctcaagct tcacatcagg aaattcttgt 2552401 gcaacgtcct cagccacttc acgccacagc cggcttgatt caagaacatt cgctttatct 2552461 acagaggtca ctttgccttt tctggctgcc gccattttga agccctctct gatcactcgt 2552521 tcaatttccg ttcgcttata aaacagtgta tctactgctt cctgctcacc ttcagtgttt 2552581 acataacgtt tgctcggctg gccgaaatac aagccgcctg tgagctcacg aacgataacg 2552641 aaatcaacat tatctatata ttcttttttc aaaggcgaag cgtcagaaag gctttcaaat 2552701 accttcacag gccgcaaatt cgcaaacaaa tcaagctgtt ttctgatgct gagcagccct 2552761 ttttccggtc tcagttccga aggattttga tcccatttcg gtccgccgac agcaccaagc 2552821 aatatcgcgt ctgcattttt acaagcagca acggtttcct ccgggagggg gttatgatgt 2552881 tcatcaatag ccgcccctcc aatcaggcca tattcaaatt caaattcatg gttaaagcgt 2552941 tcggcaacac ttttcagtac gtctgtcgct gattctaata cttcagggcc gatcccgtct 2553001 ccgggcaata gagcaatacg tttcttcaag ttaaccgttc tcctttcttt tatgatccga 2553061 cagctgtgtg gtttttcaat ccgctcatat tcgactggaa aaccaattga cggtttactg 2553121 cgttcaaata ggctttcgct gatgcttcta atacgtcttg cgctatgccc cgccctgctg 2553181 attcttttcc gttcaccaaa actcttacat acacctgggc aaatgcatct tcgccttttc 2553241 tattagactg aatgcggtag tctaagagct ccacatcctt atcgatgcag cgctcaagcg 2553301 tattgtagat tgcttccacg cttccagctc cagttgcagc ttcctgaata agctgtgcgt 2553361 tttcttgatt tttcaaagat agagtagccg tagggacctg acttgttccg taatgtactt 2553421 gcagagaaag aaattcatac ccaatcttgc gatctgttac tttttcttct aaaataagag 2553481 aaacaagatc ctcatcagtg atttcttttt tcttctcagt caactctttg aacatcgtaa 2553541 agaatttatt aatctcttca ctgtcaaatt ggaatcctaa agcagtcagc cggtctttaa 2553601 atgcgtggcg tccggaatgt ttacctagga caagcgcatc tgcggttacg ccgacaagct 2553661 ccggtgaaat aatttcataa gtcgattttt cctttaaaaa gccgtcctga tggatgcctg 2553721 attcatgagc aaatgcatta tctccaacaa ccgctttgtt gcgcgggaca gccatgcctg 2553781 tcagtttgct tactaaatca cttgttctct taatctcgtt cagcgtaata cctgtttcga 2553841 cttggtagaa atcttttctg gtatggaggg ctacggcaat ttcctctaat gccgcgtttc 2553901 cggctctttc accgatcccg ttcacagcgc attcgatttg atcagcgcca ttttcaatcg 2553961 cagcaagaga gtttgcgact gccattccca aatcatcatg acagtgggct gaaagctttg 2554021 ctttgtgaat gttcggaacg ttttctttca tatatttaaa gatatttccg tattccgccg 2554081 gggccaggta gccgacagtg tccggaagat tgataacact ggcgcctgcg tcaatcactt 2554141 tctcgacgat ttctgctaga aacggcagtt cagtgcggca ggcatcttca gctgaccatt 2554201 gcacaatcgg aaaacgttct tttgcgtatt tcaccattcc aactgctctt tcaatgactt 2554261 gttcacgtgt cattttcagc ttgtgcttca aatgaatgtc cgatgtcgcg ataaatacat 2554321 gaattcttgg ttgagcgcca tcctttaacg cttcccaagc agcatcaata tcacctttta 2554381 cacaacgggc cagaccagtt actgaacaat ttttaatggt tcttgcgatt tcctgaacag 2554441 ctaaaaagtc acctcgggac gaagcgggaa atcccgcttc aatgatgtct gccccgagtc 2554501 tttcgagctg cttagctatg gcaagtttct cctgtgtatt caagttcact ccaggggact 2554561 gttcaccatc acgaagcgtc gtatcgaaaa aattaatttt gcgcaacgga gaccaccgct 2554621 tccttcttct tgccttgttt cacaaacggc atcatttcac gaagctttct tcccactact 2554681 tcgatttgat gttcgttctc gcttgcattg atagcgttga aacgaggacg gtttacttgg 2554741 ttttcgacga tccactcttt tgcgaatgta ccgttttgga tatcttttaa tacttctttc 2554801 atagattctt ttactttggc gtccacaacg cgagggcctg atacgaaatc tccccactgt 2554861 gctgtgtcag agattgaata tctcattcct gcaagtcctt cttcgtacat aaggtctacg 2554921 attaatttca gctcatgaag acactcgaag tatgcaagtt caggctgata acctgcttca 2554981 gttaaggttt caaatccggc tttgacaagc gcgcttaatc cgccgcaaag aactgcttgc 2555041 tcaccgaaca aatctgtttc tgtttcttct ttaaatgtcg tttctaatac gcccgctctt 2555101 gcgccgccga ttcctttagc ataagcgagg gctttgtctc ttgcttctcc agtcacatct 2555161 tgatagattg cgaacaatgc aggtacgcca gctccttgct catatgttct tcttaccaag 2555221 tgtcccgggc ctttaggggc cactaagaat acatctacat ccgccggagg aacaatttga 2555281 tggaaatgca cgttaaatcc atgagcgaat actaatgatt ttcctgctgt caattcatct 2555341 ttgatttcag cttcgtatac tttttgctgc tgctcatccg gaagcagaac catgatgatt 2555401 tcggcttggg ctgccgcttc ttttactgaa aatactttat gtccgtcttc ttgggcttga 2555461 gtgaaagatt ttccttgtct aacaccgacg atcacgtcta ctccgctttc tttaaggttc 2555521 agggcatgtg cgtggccttg cgaaccgtac ccgataaccg ctactgtttt tccagccaat 2555581 acgttctctt tgatatcacc gttataatat acttttacca tttcaatctc tcccttgtta 2555641 tgttttatac aatagatatt gttttattgg atgacgcctt ttgctgggtt cccctcgcaa 2555701 aagccgttgt acctgttctc gcgatttctt taatgccata aggttttaat aactcaataa 2555761 gcgcttcaat tttgttagat tcacctgtca cctgaacaac gatgctgtct ctgctgacat 2555821 caacgacaga ggctctaaac ggttctatga ttccattaat ctctgttctt gttgaaggtg 2555881 cggagacaac cttgattaag gccagctccc tctggacaat cgattgattt gtgatgtctg 2555941 tgactttcag cacatcaatc tgtttgttga gctgtttcgt taactgttca acatcatttt 2556001 caccttcaac atgaacgacg aaggtgattc tggaaacgcc ggctgtttct gtgtgtccaa 2556061 ctgtaatgct ttcaatgttg taatgccttt ttgtgaatag accggtgatc cggtttaaca 2556121 ccccggagcg gttcaccaca gtcaatgtga taattctttt caaggtttca cccccaccat 2556181 ttcatgcagc cctttccccg gagccaccat cgggaatact ttttcttcgc tggcaacccg 2556241 cacgtcaatg acaacaggtt ctcttgatgt taatgcctct tccagctttt cctttgcttc 2556301 cgcttctgat gaaattctga tgcctttaat gccgtatgct tcggacaatt tgacgaagtc 2556361 aggctgagaa gcgaatttag attctgaata acgttcttca tagaaaattt cctgccactg 2556421 tctgaccatt ccgagacaag cgttatttaa aatcactacc ttgaccggaa gatttaattc 2556481 gcgaataaca tcgagttctt gaagcgtcat ttggaatccg ccgtctccga caaccgcgac 2556541 aacagtagca tctttttcgg ccagctgtgc gccgatcgcc gccggaagac cgaatcccat 2556601 cgttccaagt ccgcctgacg tgacccattt atctgctttt tggaacggat aaaattgcgc 2556661 tgaccacatt tgatgctggc ctacatccgt tgcgacaatg gcctctcctt ttgtaaattg 2556721 atgaatatat tcaatcaatt tctgaggttt aaaaccttct tcttcattat ctacatacca 2556781 gagcggatac tcttctttcc attctgcgag ctgttttttc cattcgcttg aatcgctttg 2556841 tttgccgtct tgtttgatca gctcctgcag gacaattttg ctgtctccga ctacaggaat 2556901 ctgtgttttc atgatttttc cgatttcagc tggatcaata tcgatgtggg ctatctttgc 2556961 gtttctggca aagtgtttca ggtttcctgt gacacggtca tcaaaacggg cgccgatact 2557021 gattaataga tcacattcat gaagggccat attggctgta taagtaccgt gcattcccgc 2557081 catccctagg aaaagcggat ggtcagccgg gaagcctccg agccccaaaa gggtgtgtgc 2557141 cacagggatt tgctgctgtt cagcataatt ttttaattct tctgacgctt ttccgtgcag 2557201 tacgcccgca cccgccagga tcaccggttt tttcgcactg ctcacggctt ccacaagctt 2557261 gcggatctgc aaataattcg gctctgttgt cggctggtat cccgggagat tcatctcatg 2557321 atcgtagctg aattctcctt caattgttgc tacatctttc ggaatatcaa tcaatacagg 2557381 tccgggtctt ccagttgttg caatatggaa cgcttcttta atgatgcgcg gcagatcttc 2557441 cggctggcga acctggtagc tgtgttttgt tactggcatc gtaatcccta aaatgtctgc 2557501 ttcctgaaat gcatcgctcc cgattacaga ggttgctacc tgccctgtaa agacgactaa 2557561 cggcaatgaa tcaatcatgg catcagcaag gcctgtaaca aggtttgtcg ctcccggccc 2557621 tgacgtggca atgacgacac ccggttttcc ggagaccctt gcgtatccct ccgctgcatg 2557681 aattgctcct tgttcgtgac ggggaaggat atgtaccaac cctgaattgt atagcttatc 2557741 gtaaatcgga agcacagccc cgcccggata accgaagatc atttctactt tctctttttt 2557801 taatgattca atcagcatta atgctccgct catcgtctgt gtacattcgg cagatgctga 2557861 atccacctgt acattagtcc ccattttagt tcctcctttt ggattttcat cctttaaaga 2557921 tcatcttttc attagctaga tagctgatta ttcaataaaa aaagcccttc cgcccacaat 2557981 cagccgcgca gtaactgcga tagctaaaag gggcgaaaag gcttttcttt ccgcggtacc 2558041 acccttgttt acggcctgtt aatcggccgt ctcatggata tttctatccg ctttagtaac 2558101 gagtgaatca agttcacccg gccaagtcct actgtcattt cagactggca ctctgaggcg 2558161 agttcacctt gtaaagcttc gccggttctc agctaacccg gttctctgtg gaaaacttta 2558221 tcaaggctac ttatcctcat ctgcgctttt catattcagc cttcggaacg gctttccagc 2558281 tgttcaagaa ggtcgtttgt ttttcatttt tttagaatca tactgcgatg attttcgctt 2558341 gtgaagcttg catttatctt ttgttgaact catattacgc cgctttggac gcagtgtcaa 2558401 cagcattttt taaaattatt agacaatttt gattaatcaa tctatattgt atacgctttc 2558461 attattggta caaaaggaat tgcaaatgtt aaaagttttt ataatttttt tattaatcta 2558521 tcaagaatac accagaatta tttaatttta tataaacatg gaagatttta taacacgata 2558581 tggttcgtat atggattgag tctgacagat catcttgcaa tccatttcaa tttcggatag 2558641 gcacttctct tgttccctcg gcatacatta atgatatctt gcaaagaaaa ggtgatacga 2558701 tgaataaatc atttgcagac atgcaaggat ttcctgcggg ctttccaagc ttccccaact 2558761 ttccgcagca gtactatcct gctgtccctc ccttttacca gcaaagccag cagccatttg 2558821 gaggctacgg atacggacag ccgttcagtc aggcatacag cccgttaacc actccctctg 2558881 gaatgtactc ctcattccca tacgcttcag gattttacgg acagcaattt tcaggtgcag 2558941 gctttagcgg ccatggcggc agcttaagtg ctccagcgat acatgccggc ggattcagcg 2559001 gggcgccagg cgtacacgga ggctttagat attaaagaat accacaaggg ccgaacatct 2559061 attgcggtcc ttttattgtt ttaaaacgac ttcacaagta cagtcacatt ttctgtcttt 2559121 atatttggaa acaggatgga atatgattaa gatgaattga acgatattct gcacaatccg 2559181 taagttttcg aggaggaata aaattgcata taaaaataga cgatttaact ggacgtcagg 2559241 tggtttcact ggtgaatgag catttacata gcatgacgct tatgtccccg ccagaaagca 2559301 ttcatgcctt aggtctagaa aaactaagag ggcctgaaat aacattttgg agcgcatggg 2559361 aaggtgatga actagctggc tgcggagcgc taaaagaact ggacacccgg catggagaaa 2559421 tcaaatcaat gcgaacatct gcatcacatt taagaaaagg cgttgccaaa caagttctcc 2559481 agcacatcat tgaagaagcc gagaagcgag gctatgagcg gttaagctta gaaacgggtt 2559541 caatggcttc atttgagccg gcaagaaaat tgtatgaaag cttcggtttc cagtattgtg 2559601 aaccgtttgc agactacggt gaagatccaa acagtgtgtt tatgacgaag aaattgtgag 2559661 acggctttat aaggatagat aagtgcaggg gaaggtctgt cttatctatc tttttttata 2559721 ttcacacatt tttcaccttt atgatacacg ccaatgtttt caattttgtt taattcaaag 2559781 aacagcggga attacaaacg acatgaacga tatcatgcaa attcataaag gaggagattg 2559841 atatgaaaag catagttggt gtatatgaaa ctccgcagga aaccatcgca gcgattgaag 2559901 gcttacttac aaaaggctat gattctgatg acatttctgt tgtgacaagc cggcgagata 2559961 cagattattt ggagtcacgt acaggaacag aagtcaatca agctatcgat gcacatcagg 2560021 acgaatctga atcttttttc gataaactga aagattattt cacaatggat gatactgcta 2560081 cacacagcaa agcattatcc gacttggata ttaaaactga tgaaatagac aagtatcaag 2560141 aagatttgga tgacggaaaa cttctggtag ccgtcgatac agatgcagat gtaattgctc 2560201 ctattgataa cggcaatgcc ctttcaggcg gcttttcaag cacaaatgaa ttggattata 2560261 caacgaaaga agaaaaaacg atgccgctcc gggaagaaca gctgaaggtc gataaggaag 2560321 acgttcaaac cggcgaagta gaaataggaa aagaagtgaa aacagaaaaa agagatatgg 2560381 acattccggt gagacatgat gaaatttatg tcgaacgccg tccagtggat gaaaataaaa 2560441 cggacgctgc tcccgtcaac gattcggaag agatcagagt tccaatcgtt gaggaaaagc 2560501 tggaagtgac taaaaaaccg gttgtcactg atgaagtggt tgtcggcaaa cgcactgttg 2560561 aagaaaatga acatatttct gaaactgtga aaaaagaaga acctcgtctg aataaagaag 2560621 gaaaagttga cggcttggat gatgatccgt taaataacaa atgaaaatca tagaccgaca 2560681 acaaaaaacc tcaaatccta aatggatttg aggtttttct tttggtacgt cccaggagag 2560741 attcgaactc ccgaccgacg gcttagaagg ccgttgctct atccagctga gctactggga 2560801 cacgttttgt ttttttgttt ttcgctttaa ctatcagcga caagatttat tatatatggg 2560861 atgcaataat aagtcaacgg ttttttagaa tttttttcat gaggaagaaa attttcttcc 2560921 tcatgacatt ttcatagtgt gactcgattt tgcagatcct caatttcatt gcctgcttgg 2560981 tcgtaaaaac ggactgtcgc agcatcattt tctaatgtca gtatagcata gctttctgtc 2561041 ctgcgcaccc tcggaagccg gatgctgcct gggttaatca tcagttttcc gcgcagcact 2561101 tcgcttcccg cgatgtgcga atgcccgaag cagataacat ccgccccgag ctcctctgca 2561161 cgatagtata cgtttaacaa ggtctgtttt ataccgtgaa ggtggccgtg tgtgactagt 2561221 atttttcttg agccggcagt cagaagaagc tcgtccttaa aatcgccggc aaaatcgcaa 2561281 ttgcctttta caaccgcata aggctccaat gcaggatgcc tcgtctcaag ctcagagtcc 2561341 ccgcaatgaa tcatgagatc aacttctgcc tcatgccgtt tcgcaatggt ttggagttct 2561401 tcttcaagcc catggctgtc actgataatc agcacgttca tgtacaagct tcctccttat 2561461 gcctccaaaa gcttagacag ctttttaagc gcgtcagccc tatggctgat tttatttttt 2561521 tcatcacttg tcagttcagc catcgtctta tctttatctt tcacgataaa aattgggtca 2561581 tagccaaagc catattctcc tctcggttct tcagcaatat acccttcaac atggccttcg 2561641 actgtttttg tttcctctcc gggaatactc acggccagtg cgcagcggaa acgggcggtg 2561701 cgctgttctt tttcgatacc tttcagctcg ctgagcactt tttcgatatt tgcctggtcg 2561761 tctttctgtt cccctgcata gcgggctgaa taaaccccgg gtctgccgcc aagattatcg 2561821 atggatagtc cggagtcatc cgcaatcacc attttgttca ctgctttggc aacagcttcc 2561881 gctttcataa tggcattttc ttcaaatgta tggcctgttt cttcaatttc ctctgtgaat 2561941 ccaatttcag ctaaagattt gacatcatag cctcttggct caagaatttc tttgaattcc 2562001 ttcacttttc ccggattatg tgttgcaata attgcttctt tcatgatgat caagcctttc 2562061 tgtctttatt tcagttctgg cagagaatca cccagcactt ctttttgctt gtcaatcagc 2562121 tcttggattc ctttttccgc aagacccaga agaccgttca gatcctctct agaaaaagtt 2562181 gcctcttccc cggttccctg caattccaca aaacggccgc tgcctgtcat gatgacattc 2562241 atgtcaactt cagcagagga atcttcttca taatttaaat ctaacaaaat tccctgttcc 2562301 ttatcaattc caacagagat tgcagcaaga aaatcagtga tcggatttgt cttgattgtt 2562361 cctgctttga tcagcttgcc aatcgcaatc gccatagcaa gaaatgcgcc tgtaatggaa 2562421 gctgttctag ttcctccatc agcttgaatg acatcacagt caatccaaat cgtccgttca 2562481 ccgagctttt ccagatctac aacagctcga agcgcgcggc cgatcaggcg ttggatctcc 2562541 attgttctgc cggaaatttt ccccttagaa gattctctga ttgttctttg gtttgttgcc 2562601 cgcggcagca tgctgtactc tgctgtaatc cagcctttcc ctccgccccg caaaaacggc 2562661 ggtacgcggt cctcaacaga cgcgttgcag attacctttg tatttcccgc tgttattaga 2562721 acagaacctt ccggatggct gataaaatcc aaatcgaatg tgattggacg cagctcatcg 2562781 tgttgtcttc cgtcatgtct catgttttac ctccgattgt atgtacataa accatttttg 2562841 tcccggaatt gaataaagaa agaggcagcc ggaacgctaa cctctttctt cctagtatat 2562901 caaaaatccc aatttaaaaa ctacccgtat tcacttgaga tggtctggag accggttctg 2562961 tgagcttttc gcctttttca tttaccagct ctgattttcc gttcacttta acagagacgc 2563021 tttttacatc cggctgctcc gttaacgtca gcacaatgct gttcagcact tctgaagaaa 2563081 tcattttcgt cttctcatcg gcgctgccga atatagattg attgaaatcc aacgtcacgc 2563141 gcccgtcttt gattttcggt ttgctgacca gctttacatc ttcactgaag tctgttaaca 2563201 gcccgctcac cttgctcggc cctttagcca attcattaat ggctgctgtg atgtcgtctt 2563261 tttccgaatt gtcgattcgt ttggtcaccg gcacgtagta ttcactgtct tcattttccg 2563321 ccaaatagta gactgtcagc ggatgggtag cagtgagatc atttacaccg gctgtttcca 2563381 aattaatgcc gtctttgcgg cttaaatcat ctgagatcgg cgtccctcct acaggcatct 2563441 ccttcagttc atgcccgttt attctcagct tcactttatc tatcgaacta aattgcgtca 2563501 gcgtccacgt cacagattga acgattttct gttcgtcttc tttcttataa tttttgaact 2563561 cattagagaa atcagctatc gccgttccat cttttttgat gtcaacgtta acggtggtgt 2563621 cagccggcaa tacagctctg aagccattcg gaagaatttc agacacaggc ccgccctgta 2563681 cgaggtattc aagcgcctgc ttagccgtgc tctcactttt aggaagaggc agcgtttgcg 2563741 caacaacata cccgttttta tcaatgagat aaagctccct cataacagta gatgaggctt 2563801 gatccgcttt tgcggtatcg cttttttcac tttctgtttt tttggctgct gttgtatttg 2563861 aattggcacc cgcttcatcg ttcacgaatg taacgtcttg aggcggatca atttcctcgg 2563921 ctgccttatc agattgaaac aaaccgcatc cggataaaag caaggcagag gtgagacaag 2563981 tggcaccaat gactgcaggt ccttttttca gcatactttt ccctcctaag gatgtttgta 2564041 ctattatgta tacgagcctc tttaggaaat agaccgaaga attccggcaa aacagaaaaa 2564101 aacccgcaac ataccgttgc ggggaaaact atcttttaat cggttcttgc agtgagatac 2564161 attccacatg cccgacttca tggccaaacc aatcgtctgc gatttttgca aactgatcac 2564221 gcgcccctgt tgtcaggaac tgatgatccg gggcaatcgg agactggttc agcagccctt 2564281 tataagagag aattgtgctg acttcccggg ctgtttcatc gccggacgaa ataatgttta 2564341 cgtgctctcc catatatctt tgaatggctt cttttaaaat agggtaatgg gtgcagccta 2564401 aaatcagcga atcaattgat gtgtctttta acggatacag cgaggtttta acaatctcgt 2564461 ctgctgtttt gtcgagaaac ttcccgcttt ccacaaaagg cacaagcagc gggcaggcaa 2564521 ggttttcaac cttcaaatca gggtttaatg ccaaaagcgc ttcttcgtat gcattgctct 2564581 taatcgtatt ctctgtgccg atgacaccga tatgctgatt atccgtcact tttatcgctg 2564641 ctctcgcacc aggctggatg actccgacca ccggtatacc gacgctgcgc tggatgtcat 2564701 ccaaagcgat cgctgttgct gtattacagg cgatcacgag cattttgatg tggtggtttt 2564761 cgagtaaata attcgtcagc tcccacgtat attgaagcac ctcttcttca gggcgcggcc 2564821 cgtaaggaca ccgtttcgta tccccgacgt agataatatt ttctttaggt agctgtctca 2564881 tgatttcctt cgcaacggtt aaaccgccaa ccccggaatc aatgactcct attggttgtt 2564941 ccaacaaaat cgcctcattt tctcttcatt tcatgctgca gtttcatcaa agatttttcg 2565001 aagatggcta tttcttcatc tgtaaacgat tcgaacatat cacgcagata ttcctgtctt 2565061 tttgtaatga cctcttggat aatccgttct ccttcaggca gcagatgtat cctgacaaca 2565121 cgtctgtccg ccgggtcctt gacccgctca acaagctcat ttttttgcat gcggtcgatt 2565181 aagtccgttg tcgtgctgca tgccagatac attttgcccg ataattcacc gattgtcata 2565241 tctcctaatt cataaagcca ttgcaagccg acaaattgcg gcggcgtaat cgcatattgg 2565301 ttaaggattt ctcgtccttt ttgcttaatg atcgcggcaa tgtggcggag tgacttttca 2565361 atatccgcaa catgctccaa aggttttgat gtcatttgtc catccctcac tcaaggatct 2565421 cttacgcaca aaagcgttcc gtgtctattt tccttctttt ttgaagaaaa tgcaagactc 2565481 gcaggagaga aatagaggac tttagtcaaa caacatcaag aaataaaatt taatttatga 2565541 cttgcctacg ttttgcacag cattccaaat atggtttcga atgttccaaa caaacagcaa 2565601 taaccggctc cttccaaaag aaggaatacc ggcaaggatt aaagctctag ctcacccatt 2565661 ctaagaagct caacaacggc ttgcgaacgc cctttcacac ccaatttctg catggcattt 2565721 gaaatatggt ttcgaacggt tttctcactg ataaatagct cgcttgcaat ctcctttgtt 2565781 gtcttatctt gaacgagcaa ttcgaacact tctctttctc ttttcgttag cagcggcttc 2565841 gattgaaatt ctttctcctt caagtattgt aaccctcctt gctaaggtga gagcgaatca 2565901 gaaacgaatg ggttttgata tagtcgagat atcatatgta agaagggcgc aggaggtgac 2565961 gtttacaaga taattagttt atcgtgtatg aagaagcgtt tctttctcct catccgtcca 2566021 gctgacagcc ttgccgcttt cctttgagac ttgaaccatc acgactgccc cggtgaagca 2566081 gggttcgcct tcgaggttct ctccgagata gtgcaaggta agagatgaac tgccgactgc 2566141 gcttgttttc acatagatgc gcaactcttc ataaggcatg acttggcgca aataatcgca 2566201 ttgctggctt gccacgactg tcatggtctg tttgttttca ctcatcatat tcagcttttt 2566261 aaaataagaa atccgcacct cctcaaaata tataaaaggg gttacattat tcatatgccc 2566321 aaacatgtct gtctcggaaa atcttacgga taccttattg aaaaaagaaa aggatgtttt 2566381 ccattcttga aacggcatat caatataagc gggaagcttc atcttttttc atctccttat 2566441 tgtttaaaaa aacctctccc atgcggaaga ggttttttct tcttatactc tgtcgcttcc 2566501 gaagaaattg cggaacgctt gtaagtttgt atctctattc aaggctgcaa tcgaagtggt 2566561 aagcggaatc cccttcggac aggattgaac acagttttgc gagttgccgc aatctgcaag 2566621 gccgccttca tccattaatg cttctaatcg ttcagattta ttcatggcgc ctgtcggatg 2566681 cgcgttaaac aggcggactt gcgacatcgg tgcaggcccc atgaacttcg atttgctgtt 2566741 cacattcggg caagcttcga ggcagacgcc gcatgtcatg cattttgata attcatatgc 2566801 ccattgacga cgtttttccg gcattctcgg ccccggtcct aaatcgtacg taccgtcaat 2566861 cggtatccac gcttttactt ttttcaatga atcaaacatt ctgctgcgat caacctgcaa 2566921 atcacgaacg actgggaatg ttttcattgg ttttaaacgg attggctgtt caagctggtc 2566981 aataagcgcc gtacaagact ggcggggttt tccgtttata accattgaac atgcgccgca 2567041 tacttcctca agacagttca tatcccatgt gacaggggtt gtcttctcac ctttgacatt 2567101 aaccggattc cggcggattt ccatcagagc ggaaatgacg ttcagattcg ggcggtatgg 2567161 aatctcaaat tcttcatcat aaggcgtgct gtcagctgta tcttgacgtg tgataataaa 2567221 tcgtatggtt ttttgttcac tcatgattat ttcgccacct tcttcttcga gtaatcccgt 2567281 ttccgaggcg ttatcagtga tacatcgaca tcctgatact caaattccgg cgcttcatac 2567341 gggcttacat gtttagccat tgttgttttg agccattcat catcattacg ttcaggataa 2567401 tccggtttat aatgggcgcc ccggctttca ttacggttgt atgcgccaag ggtaatcacc 2567461 ctcgcaagct gaagcatgtt cgagaactgg cgtgtgaaca tcgctccctg gttgctccat 2567521 tttgtcgtgt cattgatgtt gatctttttg aagcgctcca ttaactcctg aattttgtca 2567581 tccgttttca aaagcttgtc attatggcgg acaaccgtta cgttcgccgt catccactca 2567641 ccgagctctt tgtgaagaac ataggcattt tcggttccgt ccatactcat aatatcagcc 2567701 catttttctt cttctttctt aacgtgagcg tcgaataaag atgaagacat gtcttccgct 2567761 gaagattcta agccgtttac atatttcacc gcattcggac cggccaccat gcctccgtaa 2567821 atcgcagaca gcagggagtt cgctcccaag cggttgccgc cgtgcataga ataatcacat 2567881 tccccagccg caaacagtcc agggatattt gtcatttgat cgtaatccac ccataaaccg 2567941 cccatagaat aatggaccgc cgggaagatt ttcattggaa gcttacgcgg gtcgtctccc 2568001 atgaatttct cataaatctc aatgatgccg ccaagcttaa tatcaagctc tttcggatct 2568061 ttatgagaca gatcgagata taccatgttt tcaccgttaa taccgagctt ctggttcaca 2568121 cacacatcaa atatttcgcg tgtcgcaata tcacgcggca ccaggtttcc gtatgccgga 2568181 tatttttcct ccaggaaata ccatggtttg ccgtctttat atgtccacac gcgcccgcct 2568241 tcaccacgcg ctgattcact catcagtctt agtttgtcat cgcccggtat ggctgtcggg 2568301 tggatttgaa tgaattctcc gtttgcataa tacgctccct gctgataaac gattgacgca 2568361 gcagatcctg tattaatcat ggagttcgtt gattttccaa agatgattcc cggtccgccc 2568421 gtcgccataa tgacagcgtc tgaacggaag gattcaattt gcatgtttgt caggttttgt 2568481 gcaacaattc cgcggcaggt tctgtcatca tctaaaacag cgccaaggaa ttcccagcct 2568541 tcgtattttg tgaccagacc cgcaacttcg tatctgcgca cttgctcgtc cagtgcgtaa 2568601 agcagctgct gtcccgtcgt cgcaccagca taagcagttc tgtggtgctg tgtacccccg 2568661 aatcggcgga aatcaagcag gccttcaggc gtccggttaa acatgacgcc catccggtct 2568721 aataagtgga tgatcgaagg cgccgcttca cacatcgcct tgaccggcgg ctggttggca 2568781 agaaagtctc ccccgtatac cgtgtcatca aaatgttccc acggagagtc accttcccct 2568841 tttgtattga ccgctccgtt tatgccgcct tgcgcacaaa ctgaatgaga acgtttgaca 2568901 ggaacgatgg aaaacaattt aaccgccatt cctgattccg ctgctttaat tgtcgccatg 2568961 aggccggcaa gacccccgcc gactacgata atgcttgatt gactcatgat agcccctctc 2569021 cctctagtaa tctagtactc ttaaacaaat gcaaaaatcg cttttaagcc tacgtatgac 2569081 agtgcaacaa aaataatcag cgtaacgtat gtcgaaattc tttgagaacg aggcgttacc 2569141 gtgatgcccc atgtaacagc gaaagaccat aaaccgttcg agaagtggaa aattgttgat 2569201 aaaacaccga caatgtaaaa accaagcata gccggagagc tcaaaatatt cgccatcatg 2569261 tcgaaattga cctcagcacc catttgtgcg gcaatgcggg tttcccacac gtgccagctg 2569321 acgaaaatga gggtgatgat accggttaca cgctgcagga cgaatagcca gtttctcatg 2569381 tagctgtatt gaccggcgtt atttttcgca gtaaacgcta tgtacacacc ataaactgca 2569441 tgataaatta atggtaagaa gataataaaa atttccaagg catacctgaa aggcaggcta 2569501 tccataaaat gagcagcgct attgaatgct tcagcgcccc ttgcggcaaa ctggttgacg 2569561 actaaatgct gaataagaaa gatgccgacc ggtatgacgc caagcaagga atgcaatctt 2569621 cgaaaataaa actctctgtt cccagacatt actttacccc ctgtttgata agtgcgaaat 2569681 gtgctaaatc tcttccccca cttctttcaa ttgtaagcac tttattaaga tttattgaca 2569741 atttcatttt actcctccct caaaagggcg tcaagaaaac gcgtacataa attataattt 2569801 tccgaattga ttagttgatt gaaaaatttt attttatcaa tatatatttc ttgcttaatt 2569861 tttcataaga attacaggat cattctgtaa tcctcccccc tgtttgagct ataatatacg 2569921 caggagagag gggagacaga tatgaagtct aaatttgaag catctattga caacctaaaa 2569981 gaaattgaaa tgaacgctta tgcctacgaa ctaatacgag agatcgttct cccagatatg 2570041 cttggccaag attactcttc catgatgtat tgggcaggaa aacatctcgc ccgtaagttt 2570101 cctcttgaat catgggagga atttccggcc ttctttgaag aagcgggctg gggaaccctc 2570161 accaacgtaa gcgctaaaaa acaggagctt gaatttgaac ttgaagggcc gatcatttcc 2570221 aaccggctta agcatcagaa agaaccttgc tttcagctgg aggctggttt tatcgctgaa 2570281 caaattcaat tgatgaatga tcagattgcc gaatcatatg aacaagtgaa aaagagagcc 2570341 gataaagtgg ttctgactgt gaaatgggat atgaaagacc cagtgtaatc aaaaaggcgg 2570401 tgactgcata gtcccgcctt tttgattgtc attacacagc tgaagggtgt tttgaaagct 2570461 caaatgcatc gtgaagcgac tcgactgctt tcaccatgtc attttcgctt acgactgttg 2570521 acactttgat ttcagatgtg ctgaccattt tgattaaaat gtttttttgc gccagtacag 2570581 caaacatttc agccgctaca ccgggatttg agaccatgcc ggatccaaca atagatactt 2570641 tagccaattt gctttctgtc tcgattttct caaattccag cgcgtcttta tactcttcaa 2570701 gcaccgcaac ggtttggtct gcatcttctg ttttgacaga gaaggaaatt ccagtcttgt 2570761 cctcggcctg cgtttggata atgatatcca cgtttatgtt tcttttggca agtgttgtaa 2570821 aaatagtaga caaagttgtc aggccgctag tcagcccgta aatggttact cttgtgattt 2570881 gatcttcaaa tgcaatgcct ctgacaatta aattctgttc catggatgat tcctcctcaa 2570941 ttaatgttcc cgcttcggtt tctgtacttg aacgcacttc taacggcact tggtaatttt 2571001 tcgcgaactc aactgctctc ggatgaagaa caccggcgcc taaattggca agctcaagca 2571061 tttcatcgta tgagatgccc tcaagttttc tcgctgattt cacatagcgc ggatcggttg 2571121 taaacacgcc tggcacgtct gtgtatatgt cacatttatc agcttttaaa gcggcagcca 2571181 aagcaactgc tgttgtatct gaaccgcccc ggcccaatgt cgtaatttca caatcctctg 2571241 tcatgccttg gaatcctgca acaatgacaa tttttccttt ttcaagctgg tctgctaaaa 2571301 ccgaagtgtc gatatctgta attctggcgt ttccgtgaat ggcctccgta cggattcccg 2571361 cctgccagcc agtataagac acagcgtcat agcctttttc ctgcaatgcc attgaaagga 2571421 gtgaaatcgt gacctgctcg cctgtcgcca gcagcatatc catttcgcgt ttgctcggct 2571481 ggtcagaaat agcttttgca aggctgacca attcgtcagt ggattttccc attgctgaaa 2571541 cgacgacaac gacttgatgg cctttctgtt tttctgcaat tgcgcggttt gccgcatttt 2571601 gaattttttc gactgagccg acggaagtgc ctccgaattt ttgtacaata agacccatgt 2571661 attaccaccc tttacatttt ggttcgtgcg ggtgaggaga aagagcgctt tgtccacaat 2571721 aaaaaaagca atgagaggaa tactctcatt gcttatcaat taatcatcat aaatgattat 2571781 gaacaacgag atagccctcc aagaaaatga tttcttgaca gccttacatt tattcaatgc 2571841 acggccagca aataataccg atggggtttt atttgcttcg gcgacgctcc cctttcagcc 2571901 tttttcacag aatccatctt tctccaaagg catactcttg aagttcgcac ctctatcttc 2571961 accatataac acgatctaac tatgaaatta gttcacattt tatcagatct tatttaaaag 2572021 gacaacatta tttttgcaat ttgtcgtaaa ggagctgagc cgccgctgcg ggaacaccgg 2572081 cttttttgat gtcctcaagg cttgcttcct tcattttttt aacggaaccg aaatgcttta 2572141 acagcatttt ctttcttttc tctccgatac ccgggatgtc gtccaaaacg gattgaaacg 2572201 cgctttttcc ccggatttgc ctgtgaaaac tgattgcaaa acggtgcacc tcgtcctgaa 2572261 tgcgctgcag gaggtaaaat tcctggctgt ttcgttccag atacgccacc tccagcggat 2572321 caccgatcag taaatttgag gttctgtgtt tttcatcttt cgctaaaccg gcgatcggga 2572381 tatccaagcc gagttcattt tcaatgacat cccttgctgc gttgatctgc ccttttcctc 2572441 cgtcaatgat aatcagatcg ggcagcggca gattctcacg aagcactctc gtatagcgtc 2572501 ttctgacaac ctctctcata gaaccgtaat catccggccc tgtaacagtt ttgattttat 2572561 atttgcggta ttcctttttg tatggtttgc catcgataaa cacaatcatc gcggaaaccg 2572621 ggtttgtccc ctgtatattt gagttatcaa acgcttcaat tctgtgcggc gtataaatat 2572681 ttaatgcctc acctagtttc tgcactgccc cgattgaacg ctcctcgtcc cgttcgatta 2572741 aagagaattt ttctttcaat gcgattttcg catttttatg ggcaagcatg agcagttctt 2572801 ttttcgggcc ttttttcggc tggtgaacgt ttgtttccag tagctgctcg atcatagatt 2572861 gatctatgct gtccggaact aaaatctcct tcggaaggaa gtggttgttt tttgaataga 2572921 actgcccgat gaacgtgagg aactcttcat ctgcttcctg ataaagcggg aacatgctga 2572981 catcgcgttc aatgagcttt ccttggcgga tgaaaaagac ctgcacgcac atccagccct 2573041 tatcgtacgc gtacgcgaac acatcacggt cgactagatc gttcatcgtc attttttgtt 2573101 tttccatcgt tgattcaata tgggcaattt ggtcacgaag ctcttttgct cgttcaaact 2573161 caagattctc agcagcttca tgcattttct cttcaagctc ttttttgacc tcattatagc 2573221 cgccccttaa gaaacgtgta atgctttcaa ccagctctct gttcgtctct tcggaaatat 2573281 cctttacaca cggagcaagg cattggccca gatgatagta aaggcacact ctgtccggga 2573341 gcttggagca ttttctgaga ggatacagac ggtcgagcag tttttttgtt tcccttgctg 2573401 cctgtacatt cggatacggc ccgaaatagc gccctttgtc ttttttgaca ttgcgggtga 2573461 caatcagcct tgggtggcgt tcatgggtga gttttatgaa aggataggtt ttgtcgtctt 2573521 tgagcatgac gttgtatttc ggatcatgct ttttgatcag attcatttct aaaataagcg 2573581 cttcaagatt ggaggacgtc acaatatatt caaaatcctc gatttccgtc acaagccttt 2573641 gggttttcgc gtcgtgagaa ccggtgaagt aggagcgcac tctgtttttc agcacttttg 2573701 ctttccctac gtagatcaca gtctgctgcc ggtccttcat gagataacaa cccggttgat 2573761 caggaaggag ggcgagtttt tctttcagtt gtttgttcat atgttaccct tccttatgtt 2573821 taatccttta tttccagttt aacacgaacg tttgtttttc tctatggttc acaattggcg 2573881 aataaaaaaa gcgatccctc aatcggaatc gctctggcat gtaagcagcg gaaaattaaa 2573941 gatgtttgtt tacaagctct tgaagcgctt cttttggttt gaagccgact gaagtttcaa 2574001 ctacttcgcc gtcttttaac acaagaagag tcgggatgct cataacgccg tattttccgg 2574061 cagtttcttg gttttcgtct acatcgattt ttacgatttt cagtttgtct cccatttctt 2574121 gatccaattc ttcaagaaca ggtgcaatca ttttacaagg tccgcaccaa ggagcccaga 2574181 agtctgccag tacgacgcct tcgcttgttt cagctgagaa agattgatca gttgctttta 2574241 cgatagccat tattgaattc ctccaatgtg aaatgatgat ttttagtata gcatctccca 2574301 ttcgttcacg ctattttaat gcttacaaat tattttttcc tgatcacagc cggtttactc 2574361 atttttatat ggttgaatgg gatatgctct ttttttaaaa cacaaatctg ataatggccc 2574421 cgatcactac aattgcccca ataatcatta aaatggtacg aagcataaga tcacatctcc 2574481 tcttcactgt catgtacttt accatgccct gccggagctg ttttaaaacc tgaaaaagag 2574541 cgccggcatg aagctccggc gctcttgcgc gattaagaat cagcacgcag cgtaagtaag 2574601 acgactgaca ttggcgggag ttttactttc agtttgtttt tgctgagcgt gtattgtctg 2574661 aaggattccg gtttgacatg atgaggatcg tcaaacgtgt tatgcgcatt cattttttct 2574721 gccgtaagaa tgactccgga atggtccgct gccttgtgta ggcccctcag ctcgatttcc 2574781 gcctctgctt tgttttggtg atcgatgttg caaattgtga tattgatatc gccttcagct 2574841 tgtttcgacg ctgaaatgct gatttgcgga agcgtttcac cgttccattc atagtcggca 2574901 gacattgtct ctgtggctaa aagagaagcg tcctggtgca ccttaaacat attgaataca 2574961 tggtacgtcg gtgtcaaaag catccgctct ccctcagtca aaatcatcgc ttgaagaaca 2575021 tttactgttt gggcgatgtt ggccatttgc acccggcggc aatgctgatg gaaaatgtgg 2575081 aaatgagaag ccgccaccag tgcatcacga atggtgtttt gctgatataa gaaaccggga 2575141 ttcgtgcctg gctcgggatc aaaccacgtg ccccattcat caataatcag cccgacccgc 2575201 tgctccggat cgtaccggtc cataatcgtg ccgtgttttt gaatcaattc atcgatgtat 2575261 ttggcttttt tcatcgtaat aaaccattca tcttccgtga attctgtggc tgatcctttg 2575321 cccttccaga aatcccccgg aatcgtgtaa taatgaagac tcaacccgtc catcaggcca 2575381 gcggcttttt tcataagcac gtccgtccaa ttaaaatcat ccacatttgc gccgcctgca 2575441 attttataaa tgtcattccc gctgtaattg cggacataag tctgaaaacg ccggtacaga 2575501 tctgcgtagt attcgggatg catgttgccg ccgcagcccc agttttcatt gcccacgccg 2575561 aaatatttca gcttccaagg ctcttctctt ccattttgct ttctccagtc tgacatcggc 2575621 gtgccttctt caaatgtcat atactcaatc cactccgaca tttcctgaac ggttccgctt 2575681 ccgacattgc cgcaaatata tggctcgcat tcaagcagct cgcaaagcat cataaattca 2575741 tgcgttccga attcatttga ttcaattgta ccgccccagt gagtgttcag cattgtctta 2575801 cggtcaccga caccgtttgc ccaatggtat tcgtccgcaa aacacccgcc cggccaccta 2575861 aggacaggaa tgtgcagctg tttgagcgcc tccagcacgt cctttcgtat cccgttgata 2575921 ttggggatgt ctgagtccgt tccgacccag atcccctcat aaatccctct tcctaaatgc 2575981 tcagcaaaat gaccgtatat atttttgtta atggttcctt ttgcgatatc tgtttgaatc 2576041 actgcttgat gttcagacat gcctctgatc attcctttca tacggatatg aaaagcacca 2576101 cagtcaaata tgtgatctgt cgtttgcctg aggagtcagc atgaatgtaa gcgcttttaa 2576161 agtaaccata ttatatatgt tcgtacatgt caacgacatt ttctattgtt tttatatttg 2576221 tacgtatgta tttataaata tgaaaaaacc cggactttta aagtccggga tttcctttat 2576281 gagtgtatat tcagctgttt gaattcctca gttaataacg ggacaacttc aaataaatca 2576341 ccgacgatgc cgtaatccgc tattttaaag atatcggctt cggggtcttt attgatggcg 2576401 acgatcacct tgctgtttga catgccggcc aaatgctgga tggcgccgga aatgccgcat 2576461 gcaatgtaca aatccggagt aacgactttc ccggtctgcc cgatttggag agcataatcg 2576521 caataatcag cgtcacatgc cccgcgagaa gccccgactg cggcccctag cacctctgca 2576581 agctcctgca gcggctgaaa tccttccttg cttttgactc ctcggccgcc cgcaacgata 2576641 attttcgctt cggagagatc aacaccgtcc gccgtttttt tcacgacctc ttggataaca 2576701 gtgcggaggt cagtaagaga aacatcaatg ctttcgatgc tccccgatct gctggtgtct 2576761 ttttctgaag cttgaatgtt attggggcga attgttgcaa agatcatcgg atcggttgaa 2576821 atgacgcgtt caaaagcttt ccccgagtaa atcggccgtg tgaacacaac attccctccg 2576881 gtaacgctta catctatagc atcagaaatt aagcctgttt gcagacgggc agcaagcttc 2576941 ggtgaaagat ccttgcccat tgccgtatgc ccgaagatga ctgaatcagg attttcttgc 2577001 tcgataacac ctctcatgac ctggctgtac ccgtctgccg tgtatgtttt cagcttcggg 2577061 tcctcagcgg taagaacttt atctgctccg taatgaataa gctcttgtgc aatgctttgt 2577121 acattttcac cgatgagaac accgatgact tccccatctc ctgaaatggt tcttcctgca 2577181 gctattgctt caaaggtgac atttcgcaat tccccatcgc gtatttctcc aagcacgatc 2577241 actttttttc ccattctaac atccccctgt ttctttgaat gtccaagttt taaatgactt 2577301 tagcttcgct gcggagcaat gaaacaagct cttttgcctg ttcagcaggc tcaccttgga 2577361 gaagcttccc ggcttctttt ttcggcggca gaaaacgttc aatggttttc agctttggtt 2577421 cagcatcctc ttcgtccaga tcaagatcat caagttcaag ctcttcaagc ggctttttct 2577481 tagccttcat aattcccgga agcgatggat agcgcggctc gtttaagccc tgctgagctg 2577541 tgacaagcaa tgggagcgtc gttttgattt tttcaacatc cccttcgacg tccctttctg 2577601 cttctgcatc agtgccgttg atttcgagtt tggtgatcgt agtgatacac ggaatgtcca 2577661 gtagctcggc aagccgaggc gccacttgtc ctgatcctcc gtcaatggca acatttccgc 2577721 cgagaatcaa atcaaactcc tgatccttca tatagtggta taaaacttga gaaatggaat 2577781 attggtcggg ttcatcaaga tcatcttcta tgttgattaa aacagcttgg tcacaaccca 2577841 tggcaagcgc cgtacgcaat tctttctccg cttcttcacc gccgaccgtg acagcggtga 2577901 tcgtgccgcc atgcttttcc ttcagctgga tggcttcttc tatcgcgtac tcatcatatg 2577961 gattaatgat ccattccgct ccgtcatcct gaatctttcc tgtttcaatg acgatttttt 2578021 cttctgtgtc aaacgtccgt ttcatcagta caaatagatt catgatcata tcccctttta 2578081 ttcgcctttg aactgaggct ttcttttttc gagaaatgcc tggatgcctt ccttggcgtc 2578141 ctctgactca aatgcttccc caaatcgctt tgcttcaagc tttaagctgc cttcatagga 2578201 atacaccttg ttggaataaa gaagttcaag caaagatgcc agcgtttgcg ggcttttctc 2578261 tgcaaactta gcggcaagtg cttttgcttt ttcaatcact tctgcctcat ctttcgctcc 2578321 aattgagaca agtccgagat caagcgcttc ttttccggat atcggttctc ctgatccgat 2578381 gagctccagt gctttggctg taccgacata tctcggaagg cgctgtgtcc ccgcaaaacc 2578441 tggaatgata ccgagattaa gctccgggag ccccagctta gcatcttctg ccgcgattct 2578501 gatgtgacag gccattgcaa gctccagccc gcctccgaga gcagcgccgt gaatcgctgc 2578561 gataatcggt tttggaaaac tttcgattct ctccattaac tgctggccgc gctcagcgag 2578621 caatgaggaa tcctcattgc ctttaagcga tgtaaattct ttaatatcag cgccggctga 2578681 gaaaaatctt ccctcgccgt gaatgataat gcttcgtacg cctgcatctg tctcacattg 2578741 atcaagacag gaagacagct cttctaatat ccggcttgaa agcgcgtttg ccggcggatt 2578801 gtgaatcgtc aagactgcca caaattgatc aaccgcaagt gaaattgcat tcataggaca 2578861 gaactccttt acttattgtg aattccggat accaataatt ctaaaacgct gtttgaaagc 2578921 gcaacgagat cgtacttttg gtcattcatc acccaagttg tcacagtttc gtcaatcgtt 2578981 ccaaaaatca tctgccgggc gaggcggaca tcgaggcctt cttttatttc gcctgattgt 2579041 ataccttccg tcaaaatgcc atccaaaata tttaagtagc cttttaatat ttcgttgatt 2579101 ttttggcgca gctccaagtt ggattggcgg agctcaagct gcgtgacaat ggcgagatta 2579161 tggtcacccg ctaaaaggga aaaatgcttt gaaatcacaa gcgccaattt ctctttcgct 2579221 gttgcttttt ctttaatgtc ctcttccatc cgctcaataa attgacccat tttttctttg 2579281 aaaagagaaa ttaaaatatc ttctttgttt ttaaaataga gatagatggt gccgtccgct 2579341 accccggctt gtttggcaat tttggatacc tgtgactggt ggtagccgtt ttctgcaatg 2579401 acttctactg ctgcatcaat aatctgcata tactttggcc gtttttgctt caatgttcat 2579461 cgttccttcc tatagaaatg aatgactatt cattcataat ttcatgataa gaaggatttt 2579521 caggtttgtc aagtttattc ataggcgttc tcttttttta tttgatatga tgattttcgg 2579581 tttcttcttc aagtaaacgc cttcttaaaa tttttcccac cgccgttttc ggcagctcct 2579641 ttctgaactc ataggctttg ggcaccttat agggagctag acgtgatctc gcaaaagcgt 2579701 ccagttcttc tgtatcggct tttgcgcctt tctttaatac gacaaatgct tttactgttt 2579761 ctcccctgta ggaatcggga acgcctgcga caacaatttc ctggatggct tcatgttcat 2579821 aaagcgcttc ttctacctca cgcgggtaaa tattgtaacc gccggcaatg atgatatcct 2579881 tcttcctgtc agcaatatag aaaaagcctt cttcatccat atagcccatg tccccggtga 2579941 acagccagcc atctctcagc actgcggcgg tttcctctgg tttattccag tatcctttca 2580001 tgacttgcgg accttttaca atgatttctc catgctcata cggagcggca agctcacccg 2580061 tctcttcaga atagatcgca gcgtccgtac tcggccaagg acagccgata ctgcccggct 2580121 tgttttttcc ccagataaag ttggcgtgcg tcactgggga tgcctcagac aaaccatagc 2580181 cttccacaag ctttccacca gtcacctttt caaatttctg ctttacctcc acggggagcg 2580241 cggctgatcc gctaagacag cttttaatgg atgacagatc ataatgctgc aattcagggt 2580301 gatgcaaaag gccaatgtaa attgtcggtg cgccaggaaa gagcgtcggt ttgtgtttgt 2580361 cgatgatttt aagtgtttcg agcggatcaa acttaggaag aagaatcatt tcgaagccta 2580421 gtttaatcga atagttcatg actgccgtca gtccgtagac atgaaaaaat ggaacgatgc 2580481 ccagcacttt ttcagcgcct tctttcacgt catacatcca agcggcgcac atttcagtat 2580541 ttgccaaaat attttggtgc gtgagcatga ccccttttgg agctccggtt gttcctccgg 2580601 tatactggag gacagcgata tcatgctcag gatcgatctt cgggattgtc aggagttcag 2580661 ttttttcctg cttcatacag gaagcgaacg tgtgaatgtt agctgttttg tcaaagtcga 2580721 tatgcacttt ttgtttttgc gtcagcgggt aaagaatatt tttcggaaaa ggcaaatagt 2580781 cttttacact ggttatcaaa atctggtcga ctattgataa cgttttcatt tttattgcct 2580841 tcgggaaaag caaatctaag gtgatgatta cacttacctg agcatctcta agctggtatt 2580901 caagctcatg ctcggtataa agcggattcg tctgcaccac gatgccaccg gcaaacaaga 2580961 cgccataata agaaatcact gtttgcgggc aattgggcag cataacagcc actctgtctc 2581021 ctttttgcag gccattgcac tgcaaaaaag ctgcaagttt aagagcatcc gtcagaatgt 2581081 catgaaaggt gagttttttt ccataaaacg atattgcggt tttatcaggg aatcgtgcgg 2581141 cggagtctgt caggatggat tgcagggttt tattcggcaa cggaagctca tgcgggatat 2581201 cgttgggata ctcggcaagc cacggctttt gagactgcat aaaacctccc ctttcgattt 2581261 tagagatcca ccttatcatt atagcagatg gacggcaaaa aaaagaaaaa gaaaggtaaa 2581321 tctttctttt tctcataata tgaacagata tataagacca attaacaaaa agattcccgc 2581381 tgcggcgagc agtattttcg caagcttttc catctattct ccgtcccctt atattccggc 2581441 tgccaccaca aaagaaagcc cgacagaaat gacaaatgaa ataaagccga cagcccggtt 2581501 atcattttcg atttcctgat caattttaaa ccgcggagtc aaaaactcaa aaataaagta 2581561 gctgatcaga agcataacaa acccgtaaac gccccagccg atcatttgca gcagcgaatt 2581621 atgctgggag atggaatgct gaaatacgtt tgcgattccc aaaatttttc cgccggtcgc 2581681 cattgccacc gcaagatttc ctttttgaat ctcttcccag tttttataag ccgtcaccag 2581741 ctcaaacaca gtcaaaaaga ggacgaggca gagaaccgcg acactgtaat atgccgcgat 2581801 ttccacaagc tcgttttccc aaaaatcact catggccata ctccctttta ttttagttca 2581861 acaaccgtaa cgcctgatcc tccctcacct gcttcaccga aacgggaact tttgacgctg 2581921 cggtggtttt tcagaagatc ctgtacgcct tttcttaaag cgccggttcc ttttccgtgg 2581981 atgattgaca ctcttggata tccggctaac accgcatcat ccaagtattt ttcaacccgg 2582041 ctgagggcat tttcatagcg ttcgccgcga agatcaagtt caagcgatac gtgatagtcc 2582101 tttcctttga ccgctgtaat cattttttct ttttttggct ccggagctga tttgataaac 2582161 tccagatctt tttcttttac tttcatcttt aaaataccga tttgaacgtt ccattcattg 2582221 ccgcctgttt tttcgagcaa tgttcctttt tgcccgaaag tgaggacttt cacctcgtcg 2582281 ccaggcttaa agtcgcgttt ttgcgttttc ggcttttccg gtttcttgga cttttcaaaa 2582341 gcaggcatag cgccttctaa ccgtttcttc gcgttaatca gctcgtgatc cttgaaggat 2582401 ttgtgttctt cttttatggt gcgcaattca tgaataatgt cctcggcttc tttcattgcc 2582461 gcttttactt tttcagcagc ctgctgttct gcctcttcaa gcattttgtc ttttttgctg 2582521 ttaagctcga tgatttgctg ctgcagctct ttatgcagtt tttccgcttc ttttctgatt 2582581 gattctgtct cagaaagctc ttcttccgca cgttttttgc tttgttccag cgacgcaatc 2582641 atcgtatcga cttcgttatg ctcggccgtc atttctgact tcgcctgccc gatgatatgg 2582701 tccgggagcc cgaggcgttt tgaaatttcg aaagcattgc ttcgacccgg cacaccaatt 2582761 aaaagtttat aggtcggtga cagcgtttcg atgtcaaatt caacgctggc attcatgacg 2582821 ccttctctgt tatagccgta cgccttcaat tccggataat gcgtcgtagc taacactcgt 2582881 gcattggtgc gatgcacgtc atccaagatg ctcatggcga gggccgcccc ctcctgcgga 2582941 tctgtccctg caccaagttc atcgaaaagc acaaggctgt tttcattgac ctgttctaaa 2583001 atgccgacaa tattcaccat atgggatgag aacgtactta aactttgctc aatcgactgt 2583061 tcatcaccga tatcagcgaa tacgtgctca aatactgccg cttctgaccc ttcatctgcc 2583121 gggatatgaa gacctgactg cgccattaag gttagcaggc ctaacgtttt aagggtgact 2583181 gttttccccc cggtgtttgg ccctgtgatg acaatggttg aaaaatcgcg gccaagctcg 2583241 atgtcattgg caacaacctg atcaggcgga agcaatggat ggcgggcttt tttcaaacgg 2583301 ataaagccgg tgtcgttcat aatcggtttt gtcgctttaa ccgcttttgc atatctagct 2583361 tttgcaaaaa taaagtcaag cgtctgcagc acttgcaaat ctagaaatag ctcctctgta 2583421 tactctgccg ttttctctgt cagcacacgc aaaatccgtt caatttcttg cttttctttc 2583481 actttcgcct gctgaaggga attgttcata tctacaatcg cctgcggttc aatgaatagt 2583541 gtcgcaccag aggatgaggt gtcgtgcaca attcctccat agctggatct gtactcctgt 2583601 ttgaccggga tcacaaagcg gtcattccga atcgtaacaa tcgtatcaga cagcattttc 2583661 gatgcggaag aggaacgcag catcgactct aaccggtctc tgactcttga ttcgagtgtt 2583721 ctgagctgtg tgcggattcc tcttaatgtt tccgatgcat gatcaagcac ttctccgtga 2583781 tcatcaatgc aggaattaat gtcccgctct aaatcggaca gcgtgataag ctgttcagca 2583841 tgctgatgga tcagcggaat gtcgacaccg tcttcagcca tttgcgtgat aaaatgtttc 2583901 atttgtttaa ctgcataaag caggcctgag atttcagtga attcagaagg actgagaacg 2583961 ctgccgattt ccgcccgtct taacgctcct ctgatatcta caaggccgcc aaatggcgct 2584021 tggcctctca gccggataat gtcagaagct tcgtctactt catccagctg ttttttgatt 2584081 tcgtctatag aagcagaagg cttaagctcg agaagcattt cttttccgag cgatgaagcg 2584141 gcatgcccaa taacctgttc tttcacttta tgaaattcaa gagctgataa tactttttgc 2584201 tgcacgattg tgtgagcctc cttacttaat cgttgcgctt cagaaatgcc tctacgtctt 2584261 taagcgaccg ggcattcaga acgtttttcg tttccgtcca tcctttgcgc gcggcagtaa 2584321 cgccagtttt catatcgtct aacatctcaa tattatgggc atcagtatta atcaccaatg 2584381 taaccccttg ttcgtttgct ttcattaaat gctctgtgcg cagatcaagg cgcgcagggt 2584441 tggcattgag ttcaagcgcc gtatttgttt tcctcgcaag ctcaatcagc tgatcaatat 2584501 cgatttcgta accggcccgt ctgccgataa ggcgcccggt cgggtgtgcg ataatgtcaa 2584561 catgcttgtt tgtcagtgcc gtctcaagcc gtttcataat cacgtgttcc ggctgattaa 2584621 aactggaatg aatcgatgca ataacgatat ccatttccgc aagcacatcg tcatcataat 2584681 cgagcgtacc gtcaggcagg atatccatct caacgccttt caaaatacgg aagttttcaa 2584741 actctgcatt cagcgcgtca atttcttttg cctgctgctt aagtctttct gcagtaagcc 2584801 cgttggcgac ctttaaatat tgtgagtgat cggtgatcgc catgtattga tagccttttt 2584861 tgatgcaggc ttcagccatc tctctgatcg aaaatgcgcc atcgctccac gttgagtgca 2584921 tgtggagatc acctttgatt tgcccgagct ctatcagttc aatgctgtcg ctgtaggttt 2584981 ccacttcctg tccgctttca cgaatttccg gcggaatcag cggcaggccg aagtgcgcat 2585041 aaaattcacg ttcactcgga aatgttttga tctctccggt ttcaactgtc tcaacgccgt 2585101 attcactgat ccgctcgccg cgttctttgg cgatttggcg catcttaata ttgtgatcct 2585161 ttgatcccgt aaaatgatgg agtgttgtcg gaaactgctc ttccgtcaca agacggaaat 2585221 cgacgcttgt ttcatattca aaggaaagga tgacggacac cttcgtatct ccgcttgcga 2585281 tcacgctttt gatgtttggc agctcaagaa gctgctctct tacttcagcc ggatgatctg 2585341 tagcaatgat ataatccaga tccttcaccg tttcccgcgc tctgcggaga cttccggcac 2585401 gagaaaattt gatgatatgc gtaaattgag aaagatgctc ctcaatttcc cgcgcgatcc 2585461 ggagggcgta gccgatcggg aaccgttcag gctgttttcc ggcttccccg agcgcctgta 2585521 atattttttc ttccgatttt ttgccgaagc ccgcaagacc ctggaccttt tgctgctcac 2585581 aggcttcctt cagagattct gcatcgtgta cgccgagctc tttatacagc tttgcgattt 2585641 ttttgccgcc gagccccggc agcttcaata aaggcacgag tccttccggc acttctttct 2585701 gaagcgattc gagcgtgctt gactttcctt catctatata ctctttaatg acgctgtacg 2585761 ttccttttcc aatgccggac agcgacatca tatcgtccat ttctgataag cttcggtcgt 2585821 cctgttccag agctgccgcc gcttttcgga aggcggatac tttaaacggg ttgtcccctt 2585881 tgagttccat atagactgca atggtttcaa gcagccggat aatatctttt ttatgcatat 2585941 cataaccccc agacgttcac atatgtttcc atcatacttg aaaaaaactt ctccggacaa 2586001 gagaagtttt tttatgcccc gtactgtgtc cacagctctt gtaaaagccc tgacaagtac 2586061 ggtgtatggt taatgatcac atttgcgaga gacgattgcc ccatcatttg ctgcaacgcg 2586121 tctaccggca gaacggatgc gacatacagc agcacaaatg taaataaata gacttctaga 2586181 aaaccgagaa cggctcccag catctggttg atttgtttaa tcaccggaat gccggctaca 2586241 atactcagga acgagccgat gattctcagt aagattttag caatgataaa taaaacgata 2586301 aacgcaatcg cattatagta cgctgcttcc aaattccccg taaaaaaaga aagagccggc 2586361 tgtcccgctg aaaaatcggg tgcgggaatc caatgtaaat gcggtgccac gtttttatag 2586421 aataaagccg caaaggcaat tgataaaata aagctcgtca agcggataaa ctgcaggata 2586481 aaaccgcgtt ttaaccccag taaagtcccc atcaggagca agattaagat gatgatatct 2586541 agcatagttg ttcaatcctt ttctttaagc tgacgctcca gtttttcaca tttctcttgt 2586601 aatttgacat aatcgtgcac cacatttacc gctgtcagca ctgcaagttt atttatatca 2586661 aggtatggat ttttttcatt gatttctctc attttatcat caacaattcc ggcgacatac 2586721 ctcatatggg ctctgctttc ttcaccgaca atcgtgaagt gctggccgta aatgtcaacg 2586781 gttgtttttg tttttttgcc gtcagacaac gtttctcctc cattccgcga gaatcctagt 2586841 tcttatcata acacgtttat taaatgaatg gaaagacgag cctcccgctg ttatgataca 2586901 ctggtatata cagcgaaaag tgtaaaaaaa ggagattatt acgtgtccca ttcagtgata 2586961 aaagtatcgt tgtctgctat tgaccaaatg aaaatgacgt acagcggttc acttacagcc 2587021 tctgttccgc agggagccgt ttttcaggca aaaccgcccg gctgtaccat tacagcatat 2587081 caatcaggta aggtcttgtt tcaaggaaaa aacgctgcgg cagaatccgc gcgctgggga 2587141 acagcagagc ctcaggaaaa gaagaaaacg gccaaaaagc cggctgatcc ccgctatgcc 2587201 cctccggcag atatcgccgg aatgtctgtt atcggttctg acgaagtcgg aaccggagat 2587261 tactttggcc caatgacggt tgtatgcgcg tacgtcgaca aaaccatgct tcctttaatg 2587321 aaggaactcg gtgttaagga ttctaaagat ttaaaagatc cgcaaatcat cgagattgcc 2587381 cgaaacctga ttaaaaccat tccgtacagc ctgctggtgt taaagaatga aaagtataac 2587441 agcatgcagg aaaaaggcat gagccaaggg aaaatgaaag ctttgctgca caatcaggcg 2587501 atcacacatt tattaagaaa attggatgga gtaaagcctg aagccatttt gattgaccaa 2587561 ttcgctgagc caggcgtcta cttcaatcat ttaaagggca gagacattgt gaaggagcgg 2587621 acctatttta gcacaaaagc tgaaggtatt cacctggctg tcgccgctgc ttcaatcatt 2587681 gcaagatatt catttttaat ggaaatggat aaactatcac gcgcggcagg aatgacgctt 2587741 ccaaaagggg ccggtccgca cgtcgatgaa gcggccgcca agctgatcct caaaaaaggg 2587801 gcatctgcac tcagaacctt tacaaaactc catttcgcca atacgcaaaa agcgcagcgc 2587861 cttgctgata aaaaacgttc atagaaaaaa gcttgcagat ttctctgcaa gcttttttat 2587921 cagcctctta aaacagcttg atatgtgtct tctaacgctt tcagcacttt gctgtgcgcc 2587981 tttgtcactt cttcttcagt cagtgtttgt tcaggattga catactggag tgagaaagcg 2588041 actgacttct tgccttcctc catatgctct ccttcgtata cgtcaaatac ggttacctct 2588101 ttcagaagct tgcccccggc ctctttaatg acgctctcga gctgtccgct tgtgacggtt 2588161 ttatctgtta caagagcgat atcacgtgtc acagacggat attttggaat cgccgtgtaa 2588221 acaagcggtg ctgtttctgc tgcgagcaac gcatgaagat cgagctcaaa tacgtatgtt 2588281 tcctttatat ccagttcttt ttccaatgaa ggatggactt ggccgatgaa gccgatcaga 2588341 gaaccattca ataaaatgtt cgctgttctg cccggatgca gctgtttgcg ttcagactgt 2588401 acaaattcaa tgctgtctag gacgttgagt ttgtctaaca gcccttccac aattcctttg 2588461 acaacaaaga aatcaactgg tttcttttca ccctgccata gctgcttgcg ccataatccg 2588521 gtaacagctc ctgctacgcg ttctgtttca acaggttttg tgtcctcttc cttcgttagg 2588581 aaaacggagc caacttcgta cagtgcaact gagtcagtct gcctcgcaag attgtaagaa 2588641 acagaatcaa gcagatttgg aacaagactg tgtctgagaa tgcttctttc ttcactcatt 2588701 ggaagcgcaa gcacagtatt cagtgatttt tcaatcgcaa acgctgtcgc tttcttctcg 2588761 tttgtcagtg agtaagtgat ggcttgtgat aagcctgcgc cttcaaggaa gcgtctgact 2588821 ttacggcgtt ttgcctgata tggcgttaat ccgcctgtag ttcccgctgt ctcaggaagc 2588881 gtagacggaa tgttatcgta gccgtacagt cttgccgctt cttcgattaa atcctcttct 2588941 attgtaatgt caccgcgccg tgatgggaca gtcacaacga gaagatcatc cgcttcaccg 2589001 accgtaaaac cgagacgttt ataaatgctg atcagttctt ctttactgat cgtcaggcct 2589061 agaacgctgc tcactttgtc agcagatacg tgaatgttat ttgcttcgat tgtcaggtga 2589121 tcttcctcaa ccgttccagc aagcacctca ccgccggcat acagatggat cagctgcgca 2589181 gcccgttctg ctgcaagacg tacgcgtgcc ggatcaattc ctttttcaaa tcttacgctt 2589241 gattcacttc tcaaaccaag gtctttggaa gccttgcgaa ccttctgccc gttgaaatac 2589301 gcagcctcaa gcaaaatggt tttcgtatct tcctgaacct ctgactctgc tcctcccatg 2589361 acaccggcaa cggcctgcgc tttcgttccg tttgtaatga caaggtgatc ggcagacagc 2589421 ttacgttctt gatcatcaag tgttacgatc atttcattct cagctgcttt tcttactacg 2589481 acttccttag agccaaatct gtcataatca aacgcatgaa gcggctgtcc gtattccaac 2589541 aggacaaaat ttgtgatgtc aacgacgttg ttgtgcggac gaatgcctgc attcatcagc 2589601 tttgtctgca tccaaagcgg tgacggagca atcgtgacat ttttaatgat ttttgcagtg 2589661 tacagcgggt tcgcttcttg atcttcaatt ttgactgaaa tgtaatcaga cgcttgttct 2589721 gaagcagccg ggtaatccgt ttgcggaagc tttacctcag tgtctaaaat cgccgcaacc 2589781 tcgtaagcaa caccaagcat gttcatggca tccgcgcggt ttggcgttaa acccagctca 2589841 agaatcgcat cgtcaagctg taaagccgct aaggcatcgc ttcctgtttc agcgtcattc 2589901 gggaatacga aaatgccttc tgcatactcc ttcgccacaa gtttgctttc gataccaagc 2589961 tcctgtaagg aacagatcat gccgtttgat tcttcaccgc gaagcttggc ttttttgatt 2590021 ttgaaattgc ccggcagcac cgctccgact gttgcaactg cgactttttg tcccttatcc 2590081 acattcggcg cgccgcaaat gatttgtaca ggggcttcag ctccgatatc cacaaggcac 2590141 ttattcagct tatcagcatt cgggtgctgc tcgcgctcca gcacatggcc gatgacaacg 2590201 cctttgatgc cttctccttt gtattcaatt ccttcaacct caataccggc tcttgtaatt 2590261 ttttcagcaa gaacagccgg gtccatgcct tttaaatcaa cataatcctc taaccattta 2590321 taagaaacaa acatccttgc atcctcctct tacgcctgtt taaactgcga aataaatctg 2590381 acatcgtttg tatagaagtg gcggatatca tcaatgccat atttcagcat cgcgatgcgc 2590441 tcaacaccca ttccgaatgc gaagccctga tattccttcg gatcaaagcc agccatttta 2590501 agcacgttcg ggtgaaccat tccggcaccg aggatttcaa tccagcctgt tcctttacat 2590561 actgagcagc cgttcccacc gcatttaaag catgtcacat ccacttctac tgaaggctca 2590621 gtaaacggga agaagcttgg gcggagtctg atttcacggt cttgcccgaa catttttttc 2590681 gcaacaagtt caagcgttcc ttttaaatca ctcatgctga tgtttttgtc aacgacaagc 2590741 ccttcaattt gcataaattg gtgagagtgc gtcgcatcat cgttatcacg gcgatatact 2590801 ttacccgggc aaatgatttt aacgggacct ttgccttcat gcttttccat cgtacgtgtt 2590861 tggacaggag aagtttgcgt tctcatcaaa gtttcctctg tgatgtaaaa gctgtcctgc 2590921 atatcgcgcg ctgggtgttc tttcggaaga ttgagcgatt cgaagttgta gtaatccgtt 2590981 tcaacctctg gcccttcctc gactgtgtag cccataccga taaataaatc ttcaatttct 2591041 tcaatgacaa cagtgagcgg atggcggccg ccgactgcaa cagggttccc cggcagcgtg 2591101 acgtcaattg tctgtcctgc aagcttctgt ttcatttcct cttcttcaag cttctcgttt 2591161 ttgtcagcaa tcgcattggc aatacgctcc cttacttcgt tcgcgagcgc ccccattttt 2591221 ggacgttcct cagcagaaag cttgcccatt ccgcgcagca cttctgtaat cggccctttt 2591281 tttccgagat attgcacccg aatatcattg acaaccttca atgagcttgc cgcttctact 2591341 tgttctaaag cttcttgttc cagctgtttt agcttttctt ccattttgca tcctcctttt 2591401 atgtaaacaa accgtcatat gtctttggaa aataaaaaaa acccgtccct tgtacaaggg 2591461 acgagttgtg gccgcggtac cacccttatt tcagacagac tgatgctgtc gtcagcttca 2591521 ttgacataac ggaatcagat tccggttcac ctttacgcgc agtgtacgcg gtcccggcga 2591581 caactcaaga ggtgaagcca atttccggct gcgttaaaaa tgctctcagt cagcggcatt 2591641 ttctccctgg aaagcagttg atcagaaatt gaggtcctct gtcacggttt ttgaaatatt 2591701 atgttctatt atagagaaat ccaacgcttg gcgcaacact atcctcgcaa gtgatacacg 2591761 aggatggcag ccgcaaccgc aacgtttagt gattcagcct gtccgtaaag cggcacgtac 2591821 aggttcaaat ccgttttttc cagcaatgca gcatctaccc ctgcaccttc atttcctaca 2591881 atgagcgcaa aggattcaga ctgaggaatc tcctggtaag gcgctccgtt ttgcagcgcc 2591941 gtgccgtata cttttacgcc ctctgccttc aattcgtcca catatgaagg caggtttctt 2592001 ctcacaacag gaatatggaa gtgagatcct tgagcagatc gcagtgtttt tccgttaaag 2592061 gcgtccgccg tgccgtcacc gagtacaacc gcatccaaac cggccgcatc agccgttcga 2592121 atcattgtgc caaggtttcc cggatcttga acagcgtcaa tcagcagcac cttgcgtgcc 2592181 gttgccagct tttcttcagg catatggcac acagcggcaa tctgctgcgg cgtttcggtt 2592241 tcagtcacag ctgaaaacgc atcttcactc agcatatagc actggatacc agtctcaaga 2592301 tctgaaggaa tcctcgtttc atcctttaca aggatttctt tcacaatgcc cgggcttttc 2592361 aacgcctctt caacgaggtg ttctccctct atcagaaatg tatttgtttt tgttcgttct 2592421 ttttttgtgt gaagcttttt ccaatccttc actttttggt tttttgccga ttctatttgt 2592481 ttcactgtct atgtggcgct ccttttttta acatgatgtt attatatcgc aagaacagca 2592541 cataataaac caggtgcagg gttagaatat acgtattaca ttttagaaaa aggagcgttt 2592601 tacatggatc ttaatttacg tcatgccgtc attgccaatg tcaccggcaa taatcaggag 2592661 cagcttgagc atacaatcgt agatgcgatt caaagcggtg aagaaaaaat gcttccaggg 2592721 ctcggcgttt tattcgaagt catttggcag cacgcatccg aaagtgagaa aaacgaaatg 2592781 ctgaaaacgc ttgaaggcgg attaaaaccc gccgaataag acatgaaacc gggtgacagc 2592841 gcccggtttt tttcttatat aataaaaaca tgatgagggg gaacgccatg tttttacagc 2592901 cgttattagc gaaaaaaatt attgctgaag ttaaaaaaat gtacgaacgt gaagtcatta 2592961 ttgtaaacac ggacggtctt attatggcag gcacaaacga tgagcgtgtc ggacaatttc 2593021 atgagggagc gcttatctgc gcaaaagaaa gacgcagcgt gattattaca aaagaagatg 2593081 aaacaaggtt aaaaggagtg aaagcaggca taaacctccc tgtatttttt gaccatgatg 2593141 tgattgccgt cttcgggctg acaggtgagc ctgcagagat tcagccattc ggagaactgc 2593201 ttcgaaaaat gacagaactg ttcattaagg aatcgcggca cttagagcaa tcccagtggc 2593261 gtgagagaat gctggagtcc tttatgatcg attggctgca attaaaggag tggtctccca 2593321 gttttcttga gaaagctcag cttcttggtg ttgacctttc ttcccggcgc caaatgattc 2593381 ttattcaggg gtatgagtgg tcacctcatg atattgaaca aatggcacgc agctggaaat 2593441 cctcgtaccc tgcggatttg ttcatcaggt ggggaaatga acggattttg attaatcatg 2593501 aagtgccgca gcatgaacaa agggatcggc ttttgcggaa aatccttcac atttgttcgt 2593561 ttgccaatac cgcaagcagc caatatacag cagctggcgc cggaagggct gtcgcaagct 2593621 ccagcctgac agattcatac gagcaagcgg aaaaagcgct ggctgtcagc cttaagcgaa 2593681 aaacgcccat atttgaagag gatctgaagc ttgatatgtg tctgacggag atcagcccgg 2593741 gaacccgaaa cgaatttccg caaagagtat taggaaaggc gctagagcat caggaactta 2593801 tgaatacgat acggactttc tttcatcacg atttgtcttt gaaacaaacc gctgaagaca 2593861 tgcatataca catcaataca ttgcgttatc gtctggctaa ggctgaacag ctgacgggat 2593921 tacgttttga ccgtaccgag gacgtcgtca cgatgtacgt cgcactctat tttttagatc 2593981 aagatacaaa atagagagag tttcagtttc attttttgta tgtttctcca tggaaggctt 2594041 tgcttttttt cttttacaat agattgaaag cgttttttga cagggggatg ggtgaaatga 2594101 tcaccaagga tgtaaaggag cagctgattc aggtctccgg accagaaaac tttgatgact 2594161 cgaatgccgg ccgtctcgtc tattcatatg atgcgacgcc tcagtatcag tctatgcctg 2594221 atgccgtgat tgctccgagg aatactgatg aaatatcacg cattttaaca atttgcagcg 2594281 aacatcgagt gccgatcgtt ccaagaggat cagggacaaa cctgtgcggc ggcacgtgcc 2594341 cgactgaagg cggacttgtg cttctcttta agcacatgaa ccagattctt gaaattgatg 2594401 aagaaaattt aactgccaca gttcagccgg gcgtcattac gttggatatg atccgggcag 2594461 ttgaaagcaa aggtttattt tatccgcctg acccgagttc tatgaaaata tcaactatcg 2594521 ggggcaacat caatgaaaat tccggcgggc tacgcggatt aaaatacggt gtcacccgcg 2594581 actatgttat tggactggag gttgttctcg caaatggtga catcatccgc accggcggaa 2594641 aactcgcaaa ggatgtggcc ggatacgatc tcacacgtct ttttgtcggc tcagaaggaa 2594701 cactcggcat tgtgacagag gcaatcgtca aactcgttcc aaagccggaa acaaagaaga 2594761 cgctgcttgc cctttatgaa aacatcgatg ccgctgctca aacggtatcg gacattattg 2594821 ccgcaaaaat tatacccgct acgcttgaat ttctcgatca gcctacacta ttggtgattg 2594881 aggattatgc caaaatcgga cttccgacaa gcgcaaaagc agttctgtta attgaacaag 2594941 acgggccatt tgaaactgtt gaacgggata tggaaaagat tgaggcgatc tgcaaaaaag 2595001 gcgacgccgt atccgttcag accgcacaaa cagaggagga agcgtttgcc ctgactgaag 2595061 cccggcgttc tgcactttct gccctagccc gcctcaaacc gacgacgatt ttagaggatg 2595121 cgaccgttcc tcgctcagaa atcgccaata tggttaaagc gattaatgat attgctgcta 2595181 aatatgatat ttccatctgc acctttggtc atgcgggaga cgggaacctt cacccgacat 2595241 gcacgacaga cataagaaat aaggatgaaa tggaacgtgt cgaacaggct tttgccgaga 2595301 tttttgagaa agcgattgaa cttggcggga cgataaccgg agagcacgga gtcggggaaa 2595361 tgaaagcgcc ttacttggaa atgaagctga aaaaagaagg cattgatgcg atgaaagcgt 2595421 tgaaagcggc atttgacccc cggaacatat taaatcccgg caaaatgttt gcgaaagatg 2595481 ccagaaaacg tgtggtggcg gaaagatgac aacagaaaaa gaaatgaaac agatccaaaa 2595541 tgaatttaaa gagcgtatgg atgaaggaga gttattaaat tgtatgcgct gcggcttctg 2595601 tcttccttcc tgtccgacct atatcgaatc gggatttcag gaaacacact ctccgcgtgg 2595661 gcgcatcgcc ttaatgaaag ccgtagccga cggtatgatt gaaccggatg aagatgtcga 2595721 acggtcgctg tcactttgcc tcggctgccg cgcctgtgag cctgtatgcc cgtctggcgt 2595781 gaaatacggg cagctgcttg aggaagccag agatattatc caccaaaata aaaaacactc 2595841 tcttggtgaa cgtgtcatgc gaaagacggc ttttcacgag ctgtttccgc atcaaaaccg 2595901 catgcgctca gctgtaagcc ttatcggttt gtatcagcgt tcaggactgc aaaccgctgt 2595961 gcgaaaatca ggcatgcttc gggtcctgcc tgagcatttg cggacgatgg aagctgttct 2596021 tcctgatgtt ccaaaaagca aagacatgaa acatcggccg cgtttcctgc cttccattgg 2596081 ccccatgaaa aaacgggtcg cctttttttc gggctgctta atggatacaa tgtttttacc 2596141 gaccaataac gccacattga agcttttaca gctggcaggc tgcgacattg tcattccgcc 2596201 tgaacaggct tgctgcgggg cgcttcatgg acacagcggt gaaaaaaaca cagggaaaga 2596261 gctcgcgaaa caaaatatcg ctgctttcga agcattagac gtggatgcag tcattacaaa 2596321 cgcaggagga tgcggagcct ttctcactga atatgatcat ttgctgaagg atgaccctga 2596381 gtggtcggaa cgggctgccg cttttgttca aaagctgaag gatttttctt ctgttttggt 2596441 tgaactcgat ttccatcaaa tggatctagc actcgagacg cctcaggtcg ttacctacca 2596501 agattcatgt catctaagaa atgtgatgca tacgtcactt gagccccgcc agcttcttaa 2596561 aagcatcaaa ggggcggaat tcaaagaaat ggagaaagca gacagctgct gcgggtcagc 2596621 gggaatttac aacatcgtcg aagttgaaat gtctatgaaa atactggaca gcaaaatggc 2596681 tgccgtcaaa gcaaccgaag cgatcctcat tgtaacagca aatcctggct gcctgctgca 2596741 gatgaagctc ggcattgaac gcgaaggact aagcggtaaa gtcagagccg ttcacctggc 2596801 tgatttgcta ttagaagcag ccgggcacaa aacatcatga gaaagcccaa aacagacatt 2596861 gttttgggct tttgtgcgtt attccatcgg actgcaaatt tcgatataat gtccatccgg 2596921 atcagcgata taggcgaccg tctgccccca tggtttcact ttcggctccc cgataatcga 2596981 tacgccttgt tctctcatcc ttttgatgac cgcttctaca ttttcagtaa caaacccgat 2597041 ttcaaatgtg tttgaagcag atgtatccgg aatgtccagc gccgtgatgt ctctggcgct 2597101 ttcccgggta ttaagcgcca atatcgtaga ccctgtatca aattcgacat acgtgccgtg 2597161 ttcagcacga atcggcagtc ctaaaatatc ccggtaaaaa atgaatagcc cgcttgctgt 2597221 ccgatacgta tagaataaga tatttcattg atagattcat tgccaacccc tctcagcatt 2597281 ttcaatagtc cttctagccc ggtatagatg cttccatcct taagctcgga tctttccaca 2597341 tctgcgccca ttttttcaca gccgccacga taatgatgaa gcctaacacc agcatgatga 2597401 tagataatac gccattcaat acactatatc ctgctgcttc aggattgaga tacacattgc 2597461 gcaccatcca atagcccgca taattgacag tgacatataa ataggcaagc gggataaggc 2597521 aagtcagaat gtaccggcgt ttatcggcga ttttcagcac gatcgtcgct ccgataatca 2597581 gccccactga agccatcagc tgattagaaa cgccgaagag cgcccaaatg gaaccgatat 2597641 ctcctgaata cagcaagtac ccccacatca aacaggcaag cgcgctggca aatacagagc 2597701 ccggaatcca gtctgttttc ttcagcggct tatacacctc cccgaagaag tcctggatca 2597761 aataacgggc gacacgtgtg ccggcgtcaa tcgctgttaa aataaagacc gcttcaaaca 2597821 taatgacaaa ttggaaaaag tatgaggcca aatggctgaa aaacggcatt ccggtaaaaa 2597881 tataagtcat ccctaccgca agcgtgacgg ctccccctgt tcttccttct aagtccaaac 2597941 cgatttcccc gctcaattca ggcaaatgta cgacattcat gccaagcgta cggaaaacct 2598001 caggcgtgct gttaatcgca aagtaatcag caggctgtaa agcggtcgct gcaatcagcg 2598061 ccatgatacc gacaagacac tcaacaagca ttgcgccaaa cgcaaccggc ttcatatcac 2598121 tccatttatt cagcattttc ggtgtcgttc ctgagccgac aaaggcatgg aacccagaga 2598181 tcgccccgca ggcgatggtt attgagatga acggccagac aggtcctgcc agcaccggcc 2598241 ctccgccttt tacgaattct gtaaacgcag ggaacggaat ggacggattg acgacaaaca 2598301 caccaacaat caaagcgata aaaacaccga ttttcataaa gctgcttaaa taatcacgcg 2598361 gagccagaag cagccaaacg ggaagcgcag ccgcaaaaaa cgcataaaca ggaagcgcga 2598421 ttgcaagcgt tttcgtatct agcgttaaaa agtcaccgag cgcggtagtc tgtacccatg 2598481 gaccgataaa gactcctgcc attaaaaaga gaaagccgac cgttgaagcg agctttaaat 2598541 ttcccgtttt cttataaaat aagcccacac ccatcgcaat cggaatcgta atccccaccg 2598601 caaatgttcc ccatggatta cgttcaagcg catgcaagac aaccatcgac aggcccgcca 2598661 ttgtgatcgt gatgataaac agcatggaca gtcctgtaca aaatcctgca acagggccaa 2598721 gctcatcctt cgccacttcc gacagcgatt ttccgttttt gcgcatcgat gcaaacaaca 2598781 ccacaatatc atggacggct cccccaatta ccgccccgat taacagccac aataatcccg 2598841 gcaaatagcc aaactgcgcc gccagaattg gtccgaccag cggcccggcc gctgcgatcg 2598901 cggcaaagtg gtggccgaac gaaacccatt tatttgtagg cacatagtct ttcccatcct 2598961 caagcgcatg agcaggtgtt ggcttgtcat cattcacttt gagaaccttc accatcataa 2599021 atgttccgta taaacgatag gcaatagcca aaatacacat tgatgctatc acaattgtaa 2599081 ccgcattcat tttctcccat ccccttttct gtttttcata aatatatcat aatttcatgg 2599141 tgaaaagcgg tcattttttc ctatacaaaa agccggctgg aatgggccgg ctcgtggcag 2599201 ttgaaagaca agccggagag aaatctccgg ctttgctatt cttatgactg ttttttcagg 2599261 cggatcacat tccaggaaag cggcgtgaaa tgagcagtta agccgttttc gctgacagac 2599321 gatgatccgt tggaatgcgg aacgacattt tttctgttat gctggtttgt tgctttgata 2599381 tcctgatgct caagtacgat gtgctctgcg atttggtagg attcaaagcc tctgagcgaa 2599441 atctccgtct ccatctgatc ctcagccttg tttaccgcaa aaatagtgag tgtttcttcc 2599501 tcttcagagt acacaacagc agcatcaaca tatggcacat cagtgaaatc agaacaatcg 2599561 tacttaggag aagaaataag cggtttcagt gactcgcccc ttccgtaaac agaagcatgc 2599621 atgtatggat agaaaatcgg ctgtctccat gcttctccgc ctttttccgt catgatcggc 2599681 gcgatgacat taacaagctg tgcaagacac gcaattttca cacggtctgc gtgctgcagc 2599741 atcgtaatga gcagagagcc gactaataag gcatcttcaa aattgtaaat atcctctaaa 2599801 atcggacgcg cagtgatcca cggctcgact tttttatcag cctcatttga gtggtaccag 2599861 acgttccatt catccagaga gagattgata gttttcttgc tgcgtgtttt tgcttttaca 2599921 tagtcacagg tcgcagcgac tgatttgata aaatgatcca aatccataga acgtgccaag 2599981 tagtttggca gattgttatc ccggtttccg tagtaagtgt gaagagagat atagtcgaca 2600041 tgctcatacg tatgctcaag caccttcgct tcccaatcga taaaggtcgg cataccgctg 2600101 tttgagctgc cgcaggcaac gagttcaatt gatgggtcaa cccacttcat gacctttgct 2600161 gtctctgcgg caagccgtcc gtattcatca gctgttttgt ggccgatctg ccatggtcca 2600221 tccatttcgt ttcctaagca ccatgttttg atgccatacg gctgttcata gccatgcgat 2600281 cttcttaaat cactccagta agagcctttc ggatggttgc aatattcaac gagattacgg 2600341 gcggcatcta tgcctcttgt gccaaggttg acggccatat tgacctcagt gttcaccttt 2600401 tttgcccaag ataaaaattc atttgttccc acttcattgg tttctgtcgt ttgccatgcc 2600461 aagtcaagcc gtctcgggcg gttttcgact ggtccgacac cgtcctccca gttgtatccg 2600521 gataaaaagt ttccgcccgg atagcggatg atgggaacct gtaattcttt gatcagcgac 2600581 tggacatctt ttctaaatcc atcttcatcc gcttcagggt gatcaggctc gtatatgcct 2600641 tcatataccg cacgacccat atgttcgata aacgagccat aaatccgttt atctacttca 2600701 ccgattttat attctttgtc tacaatcatt cgcgcttttt tcatcacacg tttcctcctt 2600761 cattaacctt tgactccccc taccgtcagg ccggagataa agtacttttg gaaaaacaag 2600821 aaaatgataa tcaccggcaa aatcgcaaat actgagccgg atataagcat gtcgtaatta 2600881 tttccataag ggctcagcaa gctggacagc cctattggaa gcgtaaacat ttctttcgac 2600941 cgaagcacaa tcagcggcca caagaagttg ttccagctgt ttaaggactg aaggataatc 2601001 atcgcaccga aagccggttt catcagcggt gccataatcc tgaaaaagat gccgaattcc 2601061 gtacagccgt ccatccttgc agagtccagc agatctcttg gaaggccaag agcatattgc 2601121 ctgaaaaaga aaacagcaac aggtgaaacg ataaacggca atatgacacc cgtatatgaa 2601181 tcgatcaagt gcagtccgac agtaagttta aacagaggaa gcatcatcac ttccagcgga 2601241 accatcataa taatcagcac aagaacaaag atgatatttc tgcccttaaa atcataaacc 2601301 gcaagcccgt acccgatcat cgaagaaaaa aacagagtga gcacagtcgt aaaaagtccg 2601361 agtacaagac tgttaaaaaa ccatttgaaa taaatgctgc cgccattaaa cagaaatgtg 2601421 tagttatcaa aactcatcac ttttggatca atatcaagat tcagccccac acgcaaaagc 2601481 tcagatgacg gctttaatga tcctaaaagc aaacagaaaa tcggaaaaag atacaatagg 2601541 ctcagcatca taaaaaacag ggtcagcgca attctataaa cgctaaactg aggactgtgc 2601601 cgcaacattt atccctcccc cttaaacgag cctgacagct ttaatgaaat caggctgaca 2601661 acaaggatca caatcaaaag cacaatgccg atggccgctc cgtatcccat ttcattgtag 2601721 gcaagtccct gctgatacaa atatccgaca agcgtcagac caatattacc cggggaatta 2601781 ttctgccaaa ggacgtagct ttcctcaaac atcctgaagc cgccgatgat gctgatggtc 2601841 agcacatata cggttacagg cttgagaaac ggcagcgtga tgtgcagaaa ttttttcatt 2601901 gtattcgcgc cgtctatatc agcggcttcg tacagctctt tcggcacatt ttgcaaacct 2601961 gctaaaaagt aaaggatgtt gattcccatc catctccatg aagcaagcag caccatcaaa 2602021 aacatgccgg tatgttcatt gttcatccag ttctgaggtg aaaagccgag tttaagtagg 2602081 atggaattgg ccagagacgt ttccatttct ccgaagatca gccgaaaaat gatccccgcg 2602141 acaatggttg aggtcaatgc cgggataaat aatgctgatt taaatatatt tctaaatttg 2602201 accagctttg aattcaggaa tatggccaga agcaatggaa caggaatcag cacgatcagc 2602261 gtccaaaagg tgtattccag cgtattccaa agggcggtat agaacgtcgg gttgtttagc 2602321 gctgtataat tagacaatcc gacaaaggac acctctcccg gcaaaattct ttggaagctc 2602381 atgatgaaga cactaatgat ggggtataga aaaaatacga gaaaggataa aacgaatggc 2602441 gctgtaaaca gatagggcgc cgcttttttt gaataaaaca gatctcgcca gcctgattgt 2602501 ttcgcagctg aaggaacggg atgaaccgtt cccgttttca caggtttcat gagaacctcc 2602561 ccgctttcac tttttgaatg ggattctatt tctgtttcag ttcacctgcc gctctgtcca 2602621 aggcttgttt aggcgttttt tgctgagatt taagcgcgtc gaacaatacg cttctgttga 2602681 caaggtctga agccttggca aaatcctcat gtaaataaat tggattgatt tcatccttga 2602741 tatcgagcag cacagaaaaa atgcctgttc cgttttggaa gtaatccgtg tatttgtttt 2602801 tctctttcaa ttccttggag ctccaaacat cccagcgaag cgggtcaaag ccgagtacgc 2602861 tccagagttt tttatttcct tcttcagagc ccttcgcaaa ggccaaaaac tcttttgcta 2602921 actcaacatg cttggattgc ttcggtacaa cagttgccgt accgcccaaa cctgccgagc 2602981 ggtcgccccc ctctttccat gccgggagcg gtctgatggc aatcttccct ttcagatcag 2603041 gcatataatc gataaatctt cccatatacc aaatcggcat gagaactgaa gcagctcctc 2603101 cttggttcat aaagccgtag tattcttcac tgtgatgccc gccgcccggc gcaggaatca 2603161 tcgttttatc attgatcatg tcttttaaat attgaagtgt ttttacgttg gtgtcattat 2603221 tgaggatcag cttgccgttt ttatcaaaat agcctgagtt ttgctgtgaa atcatagata 2603281 agaacgttgc ggaatcattt gtttccaccg ttcccatcgg cttcccggtc actttgcgca 2603341 ctttctgtcc ggctttatgg taatcatccc atgttttaat atcgtcagga ttgacgccgg 2603401 cttttttcat cacatccatg ttataaaaca tgaccgttgt ccctacatgt gtatcgagtc 2603461 cgtaaagctt tccgtttttg ctgtacaatg tcagccgcgc ctcaacgaat ttatcgcgat 2603521 ccttttcaat cagcggagtc aagtcggcaa gcggtatgtc agagcccttc aaaaagtttg 2603581 aaaaacgggc caattcgaca tctgcaatat caggaacgcc ttctcccgct attagggaga 2603641 tagataagtt atcgtgcatt tgtccatatg gataaacgac cgtattcagc ttaattttgc 2603701 ggtcaggata ttttttgttc cattccttca ccatttccac atagaactgc tcatgaagcc 2603761 cgttaaatgt ccaaaaggtc agctcagttt cacccgattt gccggatgat ttttctgctg 2603821 aacacccggc aatgactaat gtcagcaaca tcatgagcac aagaaaacag acagtcattt 2603881 ttttcatctg cgttacccct tccattcgag gtgcgggcta ttcatataga ccatggttga 2603941 tcagcgtttt gttttcattg atgattctta atccggtgca tcggtctctt aaggtgtgcg 2604001 cgtgtctgaa ggcatttttg acggaatcct gcccgacacc gatttcgtca aaatacgcag 2604061 ggcctccggc tgatctcagc caatcagcca gcacttctcc tctcgggagt gtttgataag 2604121 ccgattggat ggcttcccgg cggcttggtg aaaattcgtt cagcccgtca tcctgagcga 2604181 gctttctgta tgtgtcagtt aataaaacag cggcacagcc cacctttgcc ccatgaagaa 2604241 tctgaggccg ttttttctcc attaactcca tttcaatcca atgtgaaata tgatgctcgc 2604301 cgcctgatgc cggtcgggaa tgatctaatg ccagcatgac aagccccgat acaagtaaag 2604361 actccatcaa aacccgtatg ccagtttccg ttttcatcgc aatgtcttct gtgtgttcaa 2604421 tgcaggcagc aagcgcctcc tgaacgatct tagctcctgc aggcgaataa ggctcaccgg 2604481 caagatgccg ggatatttcc caatctgcta aagacgtgat tttaccgagc atgtcaccaa 2604541 agccagccgc caccattgac tgcggtgccg cttttaatag atccagatca gcgaacagcg 2604601 cagatggggc cttcgtttga atggttgttt tcgtgccgta taaaataatc ggcgcaccgg 2604661 ctgatgtaaa accgtctaca gatggagcag tcggataaga aataaacggc aaatctcttt 2604721 gaaacgccgc aaagcggacg atatcatgaa tcgtgcccga accgactgcg atcatgacat 2604781 ccgttggttg tttcgtatgg atcagcacat gaatgagcga tcgttcatca gctgtcacat 2604841 ctccggcttc attttctgga atgatcaggc actcggcctg aaatccttct tgattcagtc 2604901 ggttttctaa atcaattcct gcaatgcggt gtgtattcgc gtcgcagaca aggacaatat 2604961 gttgattgtt ttttcgtttt acataatcca aaagcgaatc agctgcttgc ttaccgagaa 2605021 caatttcttc aacttttata ggcaacgtct tttctccggc gttttcaaaa gcacgctgaa 2605081 cgtcagctgc gatacgattc atatcagaat cccctcctca gccaatttgg ttacatcctt 2605141 aatagaatcc agcacataat ccggcgtgta caaacgctgt tcaccctgtt tcgcagaacc 2605201 agttagcact aaggcgcttt tcatgccata aagcttcccc atcgcaatgt cagattcaat 2605261 gctgtctcct ataatcatgc attcatgtgc ggacagcccc attgctgtac aggcagcctc 2605321 cgccatcagc catgacggtt ttccgacaac aagttcagtc ttcgcttgtg cagaagtctc 2605381 aattgccccg atcattccgg ccacatcaat ggcatttccg tcttcgttcg gaaaagagcg 2605441 gtctttgttt gtagcgataa tacgagcgcc gccggcagcc gcttgaaagg cttgatttaa 2605501 atcgtcgtac gtgagcgttt catgaaggga gatcacgagc caatccgctt ccttcggttc 2605561 gctcgcgttc tgcacaccgg ccagcctcag ctcgtcaacc aagccttgct ccccaagcac 2605621 ccataccttt gaaaaacgat aatgtttttt cagaaaagcc gctgtcacgc ttgatgacag 2605681 aacaatgtcg tttacgtccg tttcaatccc cgcgccaaga agtttttttc tgcacatggc 2605741 acgggagata ttcccccggt tgcttaaaaa gacgattttc tttcccattc tcctaagcgt 2605801 tttgatcgct tctcttgctc cttcgatcaa ctcatttcct ctgaatacag taccgtccaa 2605861 gtcaatcaga atgccagccg gtgacacagg cgtatcatga ctggccataa tacgcatttg 2605921 ctccgtgttt tcgataaaaa tgcttttcat gcaggactgt attgattggg gttacatcct 2605981 tgttcagcat aatggagtga taggccattt cggcaaccgt ttctaataca actgcgttat 2606041 gaatggcatt taaggcgtca gtgccccagc agaacggtcc gtgattattc acgagcacac 2606101 ccggcacctg ttcgtaatta tgatgctgaa aggtttccgc tatgactttt cctgtattca 2606161 gttcgtagtc atgaatgatt tcttcatcgt acatttctcg agtacatgga atcgcactgt 2606221 caaaataatc agcatgggtc gtgcctaacg gagggatgtc tctgcccgat tgcgcccagc 2606281 ttgtcgccca ttgagaatgg gtatggacaa ttcccccgat attcggaaag gctttatata 2606341 gataaacatg ggtaggtgta tctgaagaag gtttaagcga gccttcgacg acctctccat 2606401 caaggttcaa aacaaccaag tcatcggctg tcaggtcgct gtattcgact ccgctaggtt 2606461 tgatgacaat tctttctttt tcacggtcaa tgccgctgac atttccccac gtaaaggtta 2606521 ccagctgatg ctcttgaagc ttcaggttgg cagccagcac ttcttttttt aatgtttcaa 2606581 gcatgctcca tcacccttta tcaattcttt ttggcggcag atgaaaattg aagatttttg 2606641 atcgttttca gacgcttcat gacatggttt tcttttccga aataatgaac cagctcttta 2606701 tattcagcgt acaatttttc ataaaccgcg gcgttttcgg catttggcgt ataagttata 2606761 tctttcagtt ttcccatgtt cgccgctgcc tttttgatat catcgtagcc gcctttttct 2606821 ttgcctgctg caagcgcgcc gaaaatggca gatcctaagg ctggggcttg cggtgaacca 2606881 gagattttaa tgtccatgtt tgtcacatcc gcataaatct gcatgacaaa cgggtttttc 2606941 tcagctattc cgccggctgc gaacagttcc tcaatcggaa caccgctttc tttgaatgtt 2607001 tcgataatca tccgggttcc gtaagctgtc gcttcaacta acgctctata aatctcttca 2607061 ggcttcgtca gcagtgtcat gccaagcagc atccctgtta aatctgcatc aacaagagtt 2607121 gaacggtttc cattccacca atctaaagca agcaagccgc tttcaccagg cgcttgatgg 2607181 tttgctttct cactcagcag ctcatgaacg ccaatgtttt tttcctttgc ttcctcttga 2607241 taagctggcg ggacacatgt tttcacaaac cagtcaaaat gatcgccgac acaggactgc 2607301 ccggcttcat atcccgcata gcccgggaga attccgttgt ccacaacgcc gcacattcct 2607361 ggaacgatat gcacctcttc accaagtaga acatggcacg tcgaggttcc cataatcatc 2607421 agcattttcc ctggctctgt aatgccgacc gccggtaccg aaacatgagc gtccacattg 2607481 gcaaccgcaa cagccgttcc cgggagaagc cctgtcagct ttgccatttt ttcagtcaga 2607541 ctgccggctt tttctcctac tgaatgaata gaacctgaca atttgtcctt tgtaatcgtt 2607601 ttcattgaag gatttaattt ctcaaagaaa tcatctgacg gataccccgc tttttcactc 2607661 cacatcgctt tataccctgc ggtacaattg cttcgcttga gcgagccgca cagctggtac 2607721 acgatccagt ccgcagcctc gatgatccgg tcagccgctt cataaatgtg aggcgcttcc 2607781 tcggcaattt gcatgacctt tggaatcatc cattctgatg aaatttttcc tccgtaccgc 2607841 tgtaaaaaag cctctccttc ttcttccgcg atttgattga gccgatcagc atgtttttgg 2607901 gccgcatgat gcttccagag cttcacatag ctgtgcggct cctcttcata ttcaggcagc 2607961 atgcataacg gctgcccgct gctgtcaata ggaaggatcg tacatgccgt gaaatcaatt 2608021 ccaatcccga taatgtcttt cgggtcaacg cccgtctgtt cgagtaaaga cggaatggtt 2608081 gtttccaaga cttcgaggta atcagcaggg tgctgcagcg cccagtcacg cggcagcttt 2608141 tgacccgttt ttggaaggac ggtatcaatg acagcatgcc tgtattcttt tacagcagcc 2608201 gcaagttcct cccctgtttg gacatgaacg agcactgctc ttcctgataa agttccaaaa 2608261 tcaaccccta ttgtgtaagc catgtgacat ccccctctac ttttgaagcc ggtaaagcgc 2608321 ctcgttccat tttaactcgt gtttcagttt atgaattgtc gtatcacggg aaatgagaac 2608381 actttcgatt cccgccattt ccgcccaatc aagcatttgc tccgctgtca gttcataaga 2608441 caggcaggta tggtgtgcac cgccggctaa aatccatgcc tccgctgctg ttttcaatga 2608501 cggctccggc ttccagagaa cacgggcaac cggtaaattc ggcatgtctt tttcaatttc 2608561 ctggccgttg acttcattca gcacaaggcg gaaacgcccg ccaatatcaa caatgctagc 2608621 ttgaatggca gaaccgctga tgccgttaaa taccaaacgc gcagggtcct ctttgccgcc 2608681 aatcgaaagc gaatgaacct cgattttcgg ctgatccaaa gcgacagtcg gacacacttc 2608741 aagcatgtga gagcccagaa tcatttcatt tcccggttca aaatggtacg tgtaatcttc 2608801 catgaaggaa gttctttttc ctttagccat gattttcatc atccgtacaa gggccgctgt 2608861 cttccaatct ccttcaccgg caaacccata gcctttctcc atcaggcgct gaacggcaag 2608921 tcccggcagc tgtttcattc cgtgcagcac ttcaaacgat gtcgtaaacg ctgtgtatcc 2608981 gccttgctca agaaaagcgg ttaatccaag ttcaattttc gcctgttctt taatggacgc 2609041 tacctttgct tcgtcacgtt ttgtttcctc actgatcaca tatagtctgt catactcggc 2609101 ataaagcgtg tcaacctcgt cgtccgtaat gcgatccatc acttcaacga gatccccgat 2609161 gccatatccg tcaacctgcc agccaaattg aatatgcgct cccaccttgt ctccgtccgt 2609221 taccgcgaca tgacgcatgt tatctccaaa tctggcaacc ttaatatgtc tgctttcatt 2609281 taatgcagcc gccgtatcca tccactggga catttctttt ttcacttctt catcatccca 2609341 atagccggca atgacttttc ggctaagccc cattctcgag ttgatgtaac cgtactctcg 2609401 atcgccatgc gcggattggt tgctgttcat aaaatccatg tcaatcgtac cccacgggat 2609461 atcgcgatta tattgggtat gcaaatgcat aagcggtttt tgataagagg aaaggccttc 2609521 tatccacatt tttgcagggg aaaatgtgtg catccatgta atgatgccag cacatgtctc 2609581 actgtactcc gcttctctta acagctctct aatggtttcc ggtgaagtga cgacgggctt 2609641 atgagtgatt ttatatctgg aagaaatccc gctgagcccc tcacaaatgc ttttagcatg 2609701 ctgatctacg agttccagcg tctcttcccc gtataggtgc tggcttcctg tcacaaacca 2609761 gaattcataa tcctttgtct gaagcatgta aactgcccct ttctcataaa ataaaacgct 2609821 ttcaaataca aaagatacgt actaatgata gaaaataaac ctataaataa atatttgtac 2609881 gaacaatttt attatagtaa ttgactatta tactgtcaat cttttctttt aaaaaaagcc 2609941 gggggcagag cccggctttt taattcaata ggacggccag cccgagctcc aattcaaatc 2610001 attgatgaga agctttggaa tgccgttgtc attggcatca taggcatggc gaacaagaat 2610061 gtttccgttc acaatatcct ggcctccagg tcctttccat tggtcattgc ccgaatccaa 2610121 aatggtgcct ccgccttcaa gcatgctttt tccgctttta tcaagataag ggcctgtaat 2610181 gcttttggat cttccgtaag caattttgta cgtactgttt accccgtcac agcatttatc 2610241 aaatgaaacc attaaatagt aatatccatt ttgatacgta agagtaggag cttctaaggc 2610301 acctccatta ttcggtctag ctgcaatcga atagagcgag cctgtaggct tcattgtact 2610361 cttatcgagc ttagtcagct taatgccgct ccaaaacgag ccgaatgcaa gccacgggtt 2610421 gccatcctta tcgaatgtca gctccggatc aatggcgtta taattatttg agcttgtcga 2610481 acggatcacc aagccctcgt ccttccagcc ccccgaactg atgcttgttg aagatgccag 2610541 gccaatggca gatgtattgc ttccaaaaga agaaacggaa taatatagcc agtacttgcc 2610601 gttatagtat tggatgtccg gcgcccactg gttttggcca taattcggca cataattgga 2610661 ccaccacgat agcggtgtag tgaaaatgga tttttgtacg gtccaatttt tagcgtctga 2610721 agacttcaaa acccgcagtc cccgttcttc agtaagccct gttccgagcg cataccatga 2610781 gctcccctct ttaatcatag tcgggtcatg aagcagctca ttggatgcac cccaaaacgc 2610841 tgcctctgcg ggagcagcag aagtgaatat caaacctgca gccagagctg cactcgaaaa 2610901 gtgtaagaag cgtttccatg tttttttctt tttcaatttt gttcaacctc ctttatttta 2610961 gaaagcgctt acaaattaga ttatttatcc tcccttcctg tcaaatcgac tgcgtatcgt 2611021 atatcgtcat gttcaggaaa ttttcggtat cccctttatt gtagtcacta tgctgtaatt 2611081 tgtacagaca aaaaaataga atccacctca ataggcggat tcttccgtat ctttattggt 2611141 acgtaatttc gtcaaccgtt tttcggtcta acttcttaat gacttctgta attaacttta 2611201 ccgcgttttc ataatcatca cgatgcagca tggccgcgtg cgtatgaatg tagcgggttg 2611261 caatggtaat ggacagcgca ggaacgccat ttgccgtcaa atggatggca cccgaatcag 2611321 ttccgccgcc ggcaatggca tcaaattggt acggaatgcc ggcttcctcc gcagtggcta 2611381 caactgcatc gcgcaaacct ttgtgagaga ccatggatgc atcgtaaacg ataatctgcg 2611441 ggcctttgcc cattttgctc tgcgcttcct tctcggaaat gccaggcgtg tctcctgcta 2611501 tccctacatc aacaccaaac gcaatatcag gctgaatggt gtgtgcagcc gttttcgctc 2611561 ccctcagccc gacttcctcc tgcacggttc cgacgccata cactatattt ggatgatctg 2611621 tgttttgtaa gtttcttaac acatcaatag caatcgcaca gccgatgcgg ttgtcccagg 2611681 cctttgcgag taggaatttt tcattgttca tgaccgtaaa ttcaaaatgc ggaacgatca 2611741 tatctcccgg aagtacaccc cactccaagg cttcttcccg gcttgaagct ccaatatcaa 2611801 taaacatgtc ttttatttcc actgattttt ttcttgcttc aggagacaaa atatgaggcg 2611861 gcttagatcc gataacccct gtgatttctc ctttttttgt gacaatggtg acgcgctgag 2611921 caagcataac ctgagcccac cagccgccaa cggtttgaaa acggataaag cctttatctg 2611981 tgatttgtgt caccataaag ccgacttcat ccaaatgtcc ggcgatcata attttcgggc 2612041 cgttttctgc accagttttt tttgcaatta aactgcccag gcgatctgtt gtcacctcat 2612101 cagcaaatgg ttctatgtat gatttcatca cttgccttac ttctctttca ttgcccggta 2612161 tgccttttgc atctgttaaa tctttcagca tggtcaatgt ttcatctaat tttgccatgt 2612221 tccaaaccct ccttcatcag tcctgcattc ttattataca aaacatggcg ctaaccatac 2612281 gactatttca cttgaaaatc gggtatatgt ttttacagct ttcttttaga aaaagtgaaa 2612341 cctttttcta tgcttttcgt attacatcag atcatcacca taagggaggt gccttcacac 2612401 aatgtttgtc atggttctaa ggattatttt gcttgcactt tttgcttatt gtatttatgc 2612461 cgtggtcaaa tatgtcgcga atcctaagag aaggcttaag ctggcccaat caaaagaaca 2612521 tttttatatt attgatgaac aaaacaatac ccggaagaat tttcagctga cgtataaagg 2612581 cgtgcttttt gagggagaaa agcatattcc ttccaaggat catccgctgt ttattcacac 2612641 gatctttgtc tggacagaat ctcctgagaa gctgaaacat ttctctgcaa aagattttga 2612701 gaacattgaa gaaaaagtgc tggaacgata tccaaattgt aagattgact gggaccagcc 2612761 cattaaactc gcaaaaaaag cagaagagcg ttaaacgctt ttctgctttt tataaatcaa 2612821 acgggctgta gtaaatagcg atgagaatcg cttctattac cagaagaagc ggtactccgt 2612881 acttaaaaga agcgtgtttc gttttatgtc tgaaggtttg catgccaagc cagacaccga 2612941 gcgctccaaa cacgatggct atcagccaca gccggtcttc agaaattctc cacttgtgct 2613001 gctgcgcttt gcgtttgtca atgcccatca cccaaaaacc gcacagatta atcaacacca 2613061 aataagcagc aataatcatg ttgcctcatc ctttatatag aaaaagccgc tctgctggag 2613121 agcggctcta tatgattact tgtttaattg agctttagca gcatcagcaa gctgattgaa 2613181 tgcagtaaga tcgtttacag caagatcagc aagcatttta cggtttactt cgataccaga 2613241 aagcttaaga ccgtgcatta aacggctgta agaaaggccg ttcatgcgag cagctgcgtt 2613301 gatacgagtg atccaaagtt tacggaaatc acgttttttc tgacgacggt cacggaaagc 2613361 atagtttcca gatttcatga cctgctggtt agctactttg tataatgtat gttttgaacc 2613421 gaaataacct tttgctaatt taagaacctt tttacgacgc ttacgtgtaa cagttccgcc 2613481 ttttactctt ggcattgaat ttccctccta attgttcctt atccgattac ttgatgttag 2613541 caagcatttg tttgatacgt ttgaagtctc ctgcgcttac aacagcactc ttgcgaagct 2613601 tacgcttttg cttttgagat ttgttggcga ataagtgact tgtgtacgcg tgagaacgtt 2613661 ttaacttccc agaacctgtc tttttaaaac gtttagcaga tccgcggtga gttttcattt 2613721 ttggcatggg atttcctcct tattgctttt cgtttttcgg tgcgagcatt aagaacatgc 2613781 tgcggccgtc catttttggt tttgtttcga ctgtcgcaac ctcagcacat gcttcggaga 2613841 aacggtctaa tacacgctga ccgatttctt tatgagtgat tgcgcgtcct ttaaagcgga 2613901 tagaagcttt cactttatcg cctttttcaa ggaatttaat cgcattgcgc aatttcgtgt 2613961 taaagtcatg ctcatcgatt gtcggactta accgaacttc ttttaagtta atgatttttt 2614021 gattcttgcg tgcttctttt tcctttttct gctgctcaaa tcggaactta ccgtagtcca 2614081 tgattcggca gacaggcggt tttgcattcg ctgcaactaa cacaaggtca agatttgcgc 2614141 ggccggcgat ttcaagtgct tcctgacggg acttgattcc aagctggtcg ccattttgtc 2614201 cgattaaacg gacctcacgt gcacggatac cctcattaac caattgatct ttgctaataa 2614261 tgagccacct ccatagtttc ttcgaattga ttcacaactc attttgaatg cattttgcag 2614321 gcaaacaaaa agtgtgggca ttataaaaca cccacactac gaacatctgt atcaataaaa 2614381 atgtacggtc aacctgccaa ctacatgcat gtgtcaatca ggtgagaagc gggtgcttct 2614441 gcttgtgatt tatattcaat tcaataacta ttctacacaa taccggatct ttagtcaagg 2614501 acgacttatc cggaacaact tttacattgt aacatgggtt ttctatgagc gcaagagaga 2614561 aaaagaaaat ctttcatccc cacccagaat acaaagaacc aacaattccc ccttattacg 2614621 caatttacaa caaaaccacc gacaggaaga aatgtaaaac aaagttaatc tctgaccgat 2614681 ataaggagca gaagggagcc tgacacatga acaaactgat acagcttgct ttatttttca 2614741 cattgatgtt aaccggttgc tcgaatagca gcacatcttc cgaatcaaaa gtcgaaacca 2614801 ctgttaagac aacggcagca tttcctcaaa aggagctgga gaaagagcta aaaaaactaa 2614861 aacccgtttc attggacatg aagttcgaga gtccactcgc taccgagtta ggaaagcgga 2614921 aggcaaaaga ggaagctgaa aagcaaagac aaatcgccgc tgagaaaaag cttgaaaaag 2614981 agcgggaggc gaaacgaaag aaacagcagg aggaaaaagc ggagagacag cgattagcag 2615041 agcagcaggc tgcagagaga cagcgattag ccgaagcgga aagacaagct gaacttgaaa 2615101 gacagcggca ggcagcaatc caaaaagagc agaaagcgaa cgctgagaaa aagcggcaat 2615161 cgcaggcaca acggcagcag actgaggcac cctcatctaa tagtcaagat ccaccatctt 2615221 cctcgagtca gacagataaa accattcaac agccagcttc agagcttcct gatgacgatg 2615281 gttatggtta tgaagaacga aaaaagtggc atgacgatca agtagaatgg ggcattaaac 2615341 aagggtatat cgatcccgaa gacgcaccat aaaataaaaa aagccaaggc attcagcctt 2615401 ggcttatcct ccgatcagct gcacgaacac agggatgacc agaaccgtta ccactcctac 2615461 tacgacaaca gcaatacttg ccatcgcagc ttcaacttct cccatctcaa tcccgaccgc 2615521 tacaccaagt gcatgtccgg atgttccaag agccaatcct ttagaaatcg gatttttcac 2615581 tttaaacacc ttcaagaaca atgctccgag cgcatatacg atgacagcgt taaagatgac 2615641 cgcaaaggct gtgatgtcgc tgatgccccc gatgcctttt gataaaggaa gcgcaattgc 2615701 cgttgtagcc gcctgcggaa gcatgctttt cattacggcc gaatcgagat gaatgccttt 2615761 agcgagcaga taaacaatcg tgacagagca gatagagccg gcaataatgg aggccatgat 2615821 ttgccaccag tactttttaa gcttatctct ttgtttgtac aaaggaattg caaatgcgat 2615881 cgttgccggt tcaagaaaaa acttaatgat ctctcccccg ttattataat ccgcgtagga 2615941 aaaaccgccg atttttaaaa atgcgatccc cagcaccatg gcaacaaaca aaggagtgaa 2616001 aaggaagaag cctttcgttt tcttaaataa aaaggtgccg atgccgaatg cagcaagtga 2616061 tacgacaatc ccaaaataag gactcattgt gctttccatg tgaagaacct cctgtttccc 2616121 ttaatggtga acgagttcgt tattgttctg cgggctttgc actgtttttg ttttcatgtc 2616181 cgcttcggtt ttgcgttttc cgctcagcga cagaatcagc tgagaaaaca atcccgtagc 2616241 ccccagcaaa ataatcgttg cgagcagaat gacaagaaca atttgcaggc cgtattgctg 2616301 catcacacca agcgaattca taacagatat acctgatgga acaaataaaa atccgatcag 2616361 agaggttaaa gacgttccga gcgtctccac ttgttccagt ttaatgactt tcaaacataa 2616421 taggagaaat aataagacca accctacaac cgatgccggg ataggtattg ggacaatagc 2616481 ggcaatcata tttgaaacca gcataatgac ggcaaaaata aatgcttgtg ttaaaaaccc 2616541 gtacactttt ttagcactca ttttcttcac ctctttctct ttggtaccct cattataaat 2616601 aagaattccc tgttataaag cgcttacaag ataacatgcc gtatagcggg tctgagttgc 2616661 agaatcaaat ggctgaaatg caaaaagccg cccatcaaat atggagcagc tttttcaatt 2616721 ccttcgcata tgtccggctg accggtattt tcgatccgtc tttcatgatc agattatacg 2616781 ttgaattaaa ccatggctga atttctttaa tatattcagt attcacgaca aagctccgat 2616841 ggacgcggat aaaatcagaa tccggcagct ttttctcaat cacaacgagt gtatcgctga 2616901 ccgtataaga atgatcgaag gtttttacat tgacatgacc atcttctgtt ccggcataga 2616961 taatgtcctt cgtatccaca atcacaatcg attcccccac agatagcgcg agcttgtgct 2617021 ggccggcatg gctgttttgc tctgtttcta caatatcccg attgactttt ttatattttt 2617081 tcagcgtttg ctgaattctt tcttcatcga aaggcttggt taaataatca agagcgtcca 2617141 cctcaaacgc tttgagcgca tactggtcat acgctgtcgc aaacacaata gcaggaggat 2617201 gcttcatttt cttcaatcgc tttgcgatat caaaaccgtt ttctccggat aaatcaacgt 2617261 ctaaaaacag caaatcaggt ttttgatcca tcatttggtc aaaagcggat tcgatatttt 2617321 ccgcttcatt gatttccatt tcatcattgg tccgcttaag caagtaagcc agttcatccc 2617381 ttgccagcat ctcatcatca actattaaca ccctgagcat gttcttctcc ctctttcatc 2617441 tgttgcattg gcacttgaaa ggaaacctct gtccctttat gaacctcact gctgatatgc 2617501 agtgcagcct gctgtccgaa taaaccgatc agccgctgat ttaggttata aagcgctgta 2617561 ccggttccct ccttagacgg aaacggtttc ttccccagtt ccggcaagac gtccggcgga 2617621 attccgcgtc cgttatccgc caccttcata tagacggatg catcatcaga taagacacag 2617681 actgtaacct tgcatatgtc ttgttttttc ggaaacgcgt gccgaagcgc gttctcgaca 2617741 agcacctgca aaacaaacgg agggatttca atctgctcca gtctgctgtc gatattaagc 2617801 tcaattttat atttcccggg aaaacgcgcc tgttctaatg acaaataggc gttaagatgg 2617861 ttcagctcct ttgagagcgg aatcagcagc tgtctcgctc cttgaaggtt tgaacgaaaa 2617921 taaacactga gctgcaatag gagcttacgg gttttttcaa catctgtacg gcataacgca 2617981 gaaatcgtgt tgatcgcatt aaataaaaaa tgcggattca cctgtgcttg aagcgcttta 2618041 atttcagcat ccttgagaag tttgctttgc agctctgctt ccccaagctc aagctgtgtc 2618101 gaaaacagca tggccagccc ctcggcaagt tcctcctcta cctgactcag gcctgccggg 2618161 cttttaaagt acatttttaa ggtgccgatt gtattgccgt tcgatgtcag cggtaggaca 2618221 attgcagcgt gcaaagggca ttcagcatgc gtgcattcaa tctcttcctg cgaaatcgcc 2618281 ttcataatat gccctgtttt aatcaccttt ttggacaggc cggtgatcaa gcttttcgat 2618341 gggatgtggt gatccattcc cgcaccgaca tgcgcaagga tcttttcttt gtcagtgaga 2618401 gacaccgcat ctgttcctgt cagcttatgg ataatagccg ctacactttt acaggagttt 2618461 tcatttaatc cttggcggaa aaatggaagt gtctgatcag caatcgtaag cactcgatgc 2618521 gtttcgagag cccttgcctg ttcttccttg cgaatgatcg cttgaataat agacagaaaa 2618581 ataaaactgc ctgttccatt gatgagtatc atcggaattc cgatcatgct gacaagctcc 2618641 caagcgtcac tgaacggctt tgccatcagc aaaataatga tcatttgcag tgactccatg 2618701 ccgattccca caagagcggc gatgcgcggt gtcggcattc gatatcgctt cgtaaaatac 2618761 ctgccgatca agcctgcaag aacacccgct aaaatagatg agacggcaca gcttaaggcc 2618821 gtgctgccac cgagtgaaaa acgatgcagg cccgcaagta tgccgatccc agcccctaca 2618881 aaaggacctc cgagaaggcc cccgatttcc acgcccaaaa tacgggtatt cgcgatagag 2618941 cccgatggat ctatcgtaaa cacccagtca ttgtttacaa tcatatttct ttgaatttcg 2619001 atgcctgtat aattgctgat gatgctgaaa agagaaaaaa tagaaattaa aatcgctttt 2619061 cctttatagc cgtcctgatt ctgaagagct tgtctgaaaa gtttcgtatg ggcgagaatg 2619121 aaccctaata taacaataat ccccactctc tccagcatca taatcattaa atgaatcatt 2619181 catgtcacct gttctttccg ttttcattct agcatgtttt cgttttgcgg ctgactgttt 2619241 ttttaaaatc gtctgaaaac atatttcaca aggcttttat ctattgtaaa ataaaacatg 2619301 agccttttgg cagaaagatt tgaatctgaa gcagaggaga agatcatgaa agccgtattt 2619361 tttgatttag atgatacact actttgggac gaaaaaagcg tcagaacaac atttgcagaa 2619421 acttgcttac aggcggagaa aaaatatggc cttgcccctg aggaattcga agcagctgtt 2619481 cgcgaagcgg cgagagaatt gtacatgtca tatgagacgt atccatatac agtgatgatc 2619541 ggcattaacc cgtttgaagg actgtggtcc aatttctcag agccaatcag tgaaggcttt 2619601 caaaagctga acaagattgt gccggagtac agaagaaatg catggaccaa cggactgaaa 2619661 gcgcttggga tcgatgatcc tgcatatggc gaatacttgg gagagttttt tgcggcagag 2619721 cgcagaaagc gcccgtttgt atatgatgaa acttttgctg tactcgatca attaaaaggc 2619781 aagtatgaat tattgctttt gacaaatggc gatcctagtc tgcaaaagga gaagcttgcc 2619841 ggcgtgcctg agctcgctcc ttacttcaat gaaatcgtca tctcgggcgc attcggcaag 2619901 ggcaagccgg atgtttcaat ttttgaacac tgccttaagc tgatgaatat tgaaaaagac 2619961 gatgccatca tggtcggcga taatttgaat actgatattt taggcgcttc aagagccgga 2620021 atcaaaaccg tttggatcaa ccggactgat aagaaaaacg aaactgacgt aaagcctgat 2620081 tacatcatca gcagccttca tgatttgttt cctatattag agaaataaaa aaagcatgat 2620141 ctcttcaatg agatcatgct tttttatttt attttttcgc ttcagctact gcctttttca 2620201 caaactcatc aagtgaaatg gtttcagagt tctgttctcc gtatttacgc acgtttaccg 2620261 ctccgttttc tgcttcttgg tcaccgacca ccagcatgta cgggattttt tgcatttgcg 2620321 cttcacggat tttgtagccg attttttcat cgcggctgtc gacttcaaca cgcaggcctt 2620381 cacattgcag gcgttcctgc acttttttcg cgtagtctaa atgcacagcc ggagaaaccg 2620441 ggatgacttg gaactgaacc ggtgcaagcc atgtcggcag cgcgcctttg tgttcttcga 2620501 ttaagaaagc aacaaagcgt tccattgttg aaacgacacc tctgtgaatg acaaccggac 2620561 ggtgctgctt gccgtcctca ccgatgtatg tcaggtcgaa acgttccggc aataagaaat 2620621 caagctgaac cgtagacagt gtttcttctt ttccgatcgc agttttcacc tgaacatcaa 2620681 gtttaggtcc gtagaatgcc gcttcacctt ctgcttcgta atagtcgtgg ccgatttcat 2620741 ccattgcctc tttcagcatg gattgcgctt tgttccacat ttcatcgtca tcaaaatatt 2620801 tctctgtatc ttccggatcg cggtaagaca gacggaatgt gtaatcactt aaaccgaagt 2620861 cttcataaac atcctggatt aaacggactg tacggataaa ctcatcctta atttgatccg 2620921 ggcgcacaaa gatgtgtgca tcatttaacg tcattccgcg tacccgttga agtcctgaca 2620981 gcgcacctga catttcatag cggtgcatcg ttccaagctc tgcaatacga atcggaagct 2621041 cgcggtaact gtgaatgtct tgtttgtaaa tcatcatatg gtgcggacag ttcatcggac 2621101 gcaatacaag tgtttcattg tccatttcca tcggagggaa catgccttcc tgataatgat 2621161 cccagtgtcc tgatgtttca tacagctctt tgctgcctag cacaggtgtg tatacgtgct 2621221 catagccgag gctgatttct ttatcgacaa tgtagcgctc gatgacgcgg cggattgttg 2621281 cgccttttgg cagccaaagc ggcaggcctt gtccgacttt ttgagagttc gcgaacagct 2621341 ttaattcttt gccaagcttt ctgtggtcgc gttctttcgc ttcttctagc atacgaagat 2621401 gctcttcaag atcagctttt ttgaagaaag ctgtaccata tacgcgctga agcatttggt 2621461 ttttgctgtc accgcgccag tatgcgcctg caaggcttaa cagcttaaat tctttgattt 2621521 ttccggttga aggaacatgg acgccgcggc acaggtcaaa gaattcgcct tgctcataga 2621581 tcgaaacggt ttctccttca ggaatcgcat ccaatagttc aagcttcagg tcgtcgccga 2621641 tttccgcaaa acgggctttc gcttcttcac ggctgacttc ttttcgaacg atcggaaggt 2621701 tcgcattaac gatttttttc atttctttct cgattttcgg cagatcctcc ggtgtaatcg 2621761 cttcgtccat ttctacatcg tagtaaaaac cgttttcgat aaccggaccg acgccgaatt 2621821 taacatcctt gtagatgcgt ttaatcgctt gagccagcaa gtgagccgca ctgtggcgca 2621881 taatttgaag accttcttct gagccttctg taatgatttc cactgtaccg tcttcattga 2621941 tcggcgttct caaatcgatt tcttttccgt tcagttttcc ggctaatgac tttttcttta 2622001 atcccggact gatggatgcc gcgatatctt ctgttgttgt tcctttcgca aactccttga 2622061 ctgctccatc aggaaatgtg atttttacca tatctgacat ctttgtcact cctttttttg 2622121 catataaaaa ccccgccccc tatgaaaggg acgaggttga ataaacggaa tcgtggttcc 2622181 accctttttt ccgcaaagcc aatacacggc acctgcggct ctaagctctg taacgggagt 2622241 tcccgtcagc cattactgtt ccttttcaag aggttcacag ctgaagttca aaggcggtaa 2622301 agcgaatggt ccttagctgg gaagcttgca gccagggctt ccctctcttt gagccggtat 2622361 cattccttcg tgtccttatc aatacgtgtg tctttcttaa tctcctatgt attataaatt 2622421 gttcaatcca aaaaatcaac acgatcgcgt ttcctttttt ttaaaccgac agccttaaat 2622481 agacaggctg ccggccctca tccttccgag tgcttcaccg gtatttctgc atctgtaaaa 2622541 gcatgcagcg ggagcatttc cactctctct tgaaatacgt tttgaatggt ccttgccatc 2622601 atgtgctcgg gctggtcggt ataaagcacg acttcatcag gcgcaatgga aatcagcggc 2622661 gcgagcaaat gagaatcaat atacatagga tgatcccgga caaatcttct gtctatgtat 2622721 ttcatttttt cccgttccgg cacatagcgc agctcccata atgtaaagga accatcatgg 2622781 acaatatgca cttttttgat tcgcggctgt ttggcgtcca catagtctct gagtgtttga 2622841 ataaagtttt gatattcctg ttccatctta tattcatcaa tcgctgcttc tgtaatatct 2622901 ctcagctgct tatagtatga tccaagtcgg aaggtctgaa aggagcgaat gtaaaatact 2622961 ccttcctcta aacagatcgt ttggagttca tccaaaattg attgtttccg tgaaagcttc 2623021 agcggctcaa acggaagatc gtctgcttca ccttcaataa tactgtgtgc gagctgaagg 2623081 atttgctgct gttcatcctg gtccgtgaaa caatacgttt cctcaatcaa tgacagcata 2623141 tgctcgtctt ctttgcattc caaaaaaaat ttgaccagaa tcggctccat aaaacgctga 2623201 ataggaaaag ccggattcgc tttttcaatc ccgatttttc gtatgccttc acggacaatg 2623261 atattgttcc gatcgtccga atgctgaatg agatgtaaaa aagcggctgc atcatggtca 2623321 tcttcaaaga ttatttcaag catgtttgtc cccccttacg gcatctgtta caagtatatg 2623381 ggggatgttt ttaaaataga cgtaaaggtc attggcaaat cttaatttga ttcttggaac 2623441 aagttttgca ttttctttct gaagatgaac ggcaatgaga taaacacgat atacaaagcg 2623501 agcaccataa agaaagcggg cagattgcca gccaaaaagc tcgcacccag cacattaagc 2623561 gcaatcgtcc cagggatgat tcccacagcc gttgcggcaa aatacggcag cgctttgaca 2623621 ttggaaaggc ctgccgcata gctgacgaaa tcaaaattga tcggcaggat tctcaaaaga 2623681 aagatataga aaaatccgtt atcctccatt tgcttctgta tggcttcaag cctttcgtaa 2623741 tgcccgttct ttttcgccga aaacaaacca gccgcaaaaa acgaaacagc tgaagcgcac 2623801 atcgaaccga ataacgtata aagcgtgccg agaagcgggc caaacgcaag tccgccagct 2623861 attgaaataa cagacaccgg aaataaaaca agtggcctga cgatggatat cccgataaac 2623921 atcagaggtg caaagactcc gaacgacaat acccataccc tgatttcttt cggcgataca 2623981 ttcaaatacg ttttatttcc ccaatagagt aaaccagcac ctgcaagcac tgccagccat 2624041 ttgacagccg tttttcgttt cataccctca gttccttccc ctttgaacca cagcaattat 2624101 ggatgtcggc ggttttctcc gtcaaggcgg atcggagcag ccaaatataa tatccgctcc 2624161 attaatcttg cagcttttac ttcttctttt tctcccctct gcgaatacgt aaaatgatgc 2624221 ttcagctcgt caggtgagaa attagaagaa aagaacgttg gcagctgctg ggacattctg 2624281 tgctgaagca ccgttccgat gacctcatcc cttacccagc ttgtcattga ttctgctccg 2624341 atgtcatcaa gcattaatac gggtgtggtc tttaccatat tgagcttctc ttccaatgtc 2624401 tggtcttgca gcgaattctt aagctctctc acaaattcag gcacataaac aatcatggag 2624461 gaatactctt tttccgccag ctcattggca attgcagcga gcataaacgt ttttcctacc 2624521 ccaaatttcc cgtataaata taatcctttc ccttttcccg tctcattata gcttttcagg 2624581 aagtctgtaa catgctgaaa catcgcgagt ctgcttgggt cactgatatc aacttgctgg 2624641 aacgtcgctc caagaagatc ctgctggata tacatgcttt tcataagaga ctgttgtttc 2624701 ttctgctggt cgagcttccg tttgactgga cattcgtaat actcgatatc aatagacctc 2624761 ccattgacaa caagcttcgg atggtagccc tccaacaaat tgttgcagtt ttcatcttcc 2624821 gaacaatagg agcaattctt gctttgttcg atatattcat aaagcttatt taagctcttt 2624881 tcgatcattt tttggtcaat cacttcttcg ttttccttca aaaatgcttg aacatcttga 2624941 tctttcatga ctttttcctt catttgttca agacgttttt ggaaatccgg cctgccggtt 2625001 acgccctgca gggaacggcc gattggttcc atctattcct tcaccccgca tctctgtctt 2625061 taataggcag agtatttttt cagtttttgc atttcttcca tcatcttttt cttctgttct 2625121 tccaaatcct gcggatgcag cttctgctgt ccggattctg aatcggacgc tgtttccttt 2625181 tctgtcatcc aatcaggaag cttttcttca cgaatcactt tttggtttcg tttcgaagac 2625241 tttgtttttc cctcagccca ttcaagatac tggcggtttt cttctattgc gagcttcatc 2625301 gcttccctga ccgttttcac ctttttgcgt gcccaatgcg aagcgatttt ttggatatag 2625361 tttttcgaca gcttcatgtc ggttttcagc atgacataat aaattaacac atttgtgacg 2625421 cctggctcga gcttctgttc gaacataatt tcttctatga tcttcagatc agcttttgac 2625481 ggctctgttc cgtcagcaat gtcctgcaga agcttcttcg gggaaatcgc ctccagcaat 2625541 gcaatcagct tcccatccag agaatcctct tctgccggtt gttcgccttc acgcagatgc 2625601 accggctgtg ttttttccac caaatcgggc agctgtccgt ttctttcaat ttgataccag 2625661 tcgctcgccg cttttcttaa tgcctccgtc gtaatgacgt cacgctcatc aattgcgctc 2625721 atcacaacat tttgcatttg caaagggtca attccgtaca gataagaaag ctttttgatt 2625781 gtgtcccgca cctgctgggt catcgctttt ctcggtatca tcgtctcaga aagtcccgct 2625841 aaaaacaaat caaaatcaaa cacatcctcc gttatggtgt aggacggaga ctgtccgaca 2625901 gaagtatact cggacccctc ggcaagcctt accgtttcct ccatatcgga tgtgagcttc 2625961 cattcactcg gctgcagcga ttcaaacgca tgattaaacg gacgcgtaat gtccttcgca 2626021 tcttctgaaa tggccgggtg cgtaaaaaat tgttttaatt gctgatattt cgtttttccg 2626081 accctattat acagaaaaac attcagcatt ccgtcttcaa aaaattcatt tggtctgagc 2626141 ggcggaagga gttcatatat aaagaggcgc tcctgccgct cggattcttt catatatact 2626201 ttcagcaatc cgatgccctc gagcttcccc tgttcctgat ggatcgtttt taagttggac 2626261 tgtgtcatcc ccatcagctg tctatgtgtg gactctccgc cccacagacg gttttgttca 2626321 agctctcccc acaatgtcat ataaagagag aatgcaacag ggccgattaa gggctggtac 2626381 agttgtgtaa taatttgtct gtcaatatcc tgcagcatcg atctgctttt aaccacatac 2626441 gggtctacag gcagtacatc tttccaatag tcagccatac attctcaaac cttccgaatt 2626501 tgtttctacc tttcatttta caccgtttct tatatctatc aaatgccaat tttgcacatg 2626561 agaaaagagc tagaagaatc ctcttagctc ttttaacgct ctttctttat taagtctttt 2626621 aattcatcga taaagacgtt tatatcttta aactgccgat agacggacgc gaaccgcaca 2626681 tatgcgactt cgtcaatctt agccagccgg tccatgacca tttctccgac gagctcactc 2626741 ttcacctcgg agcagccttg attgcgaagt tctttttcaa tatcaaagca catgtcttca 2626801 agcgttttga gtgaaacagg ccttttttca catgctttta tgaggccgcg cagcattttt 2626861 tctctgctga attcctcacg cacaccttct tttttcacaa cgatgagcgg ggtttcctcc 2626921 actttctcaa aggtcgtaaa ccggtagtgg caggattcgc actcgcgtct tcggcgaatc 2626981 gactttccgt catccacagg ccgtgaatca aggactcgtg ttccgttatg ctggcatgaa 2627041 ggacatttca ataaaatcag ctcccaacta tatcgttccc tgcaatgtat tttcggcagc 2627101 ctccgccttt taaaaataga tgtgacagca tctgtcggga gagccgttgt taaatttgtt 2627161 tctatagcat taggtggttt gtgaaaatct ccttcttatt ttacaaaaaa aatgaaaaaa 2627221 gaaaaagctg acactctcgt ttctttataa aaataaaagg agcataagct aaaaagcgca 2627281 taatggcttt ctagcttcag ctccctttgt gttcgcaatt tactttatag tactttcgct 2627341 tgcgcctgtt taatttgcac aggccccatt cctcttggta tttcaatgtt ttctcttgta 2627401 tcagcatgta atgcctctgc aatgtaatca gcagcgacat taggatctaa gtctccacaa 2627461 gtataaacat caatgctcgc atatccgtgc tcaggaaaac tgtgaatcgt taagtgtgat 2627521 tcagaaataa tcacaactcc gcttacgcct tgcggtgcaa atttgtgaaa tgcaacctcg 2627581 cgcacctcag cacctgattt tagagcagca tttacaaacg ttttttcaat aaaatccatg 2627641 tcattcagct tatcaaaatc gcatccccat agctcggaga taacgtgacg ccccattgtt 2627701 tccatagtca tggacccccc ttaacaagaa ttaaaaagtg aaattccaac aactgggtcg 2627761 gccatttacc acgggggaaa gttagtccgg agaggtccta accctttaag taattccgaa 2627821 acagtctcaa gcaagaagtt cacgaaaaat agtatactgt gtttaagtct aatttgcaag 2627881 gtgcgttttt tcagaaatat gctgttaagg gttttttctt taaaatgtgt ccatgacctt 2627941 attttataca gcagacggat gtttcattcg tgccgctaca tggcggatta gatcaacaac 2628001 tctgcaggag tagccccatt cgttgtcata ccacgccagc acctttactt tcctgtcttc 2628061 cattaccatt gttgtaagcc cgtcaatgac cgctgaatgc ggattcgtat tataatcagt 2628121 cgaaacgagc ggttcatctg agtaatcaag tacaccgtac atcgacgttt tggcagcgcg 2628181 tttaaatgcc tcgtttactt cttcagccgt aacatccgtt ttcagatcaa caacgagatc 2628241 aaccaatgag acgttcggaa cagggacacg caaggcgagg ccgtgaagtt ttcctttcag 2628301 atgcggcagc acaagcgaaa gcgcctttgc cgctcctgtt gttgttggaa tgatggattc 2628361 accgcaagcc cgcgcccggc gcaaatcttt gtgcgggtta tcaatatttt tttggtcatt 2628421 cgtatacgca tgaactgtag tcatcagacc gctctcaatg ccaaactctt catccagcac 2628481 ttttacaaca ggcgcaaggc aatttgtcgt gcatgacgca tttgaaataa tgacatggcg 2628541 ctcagcgtcg aattggtcct catttacgcc catcacaatg gtaacgtctt cattttttcc 2628601 cggagcggtc aaaatcactt tttttgcacc tgcttctata tggcccatcg ctttatcttt 2628661 agcattaaac ttccctgttg cttcgacgac tatgtcaata tcatattccc gccaaggcag 2628721 ctgttttgga tcacggctgt ttaacaaaag cactttcttt ccatttacga tcaggctatc 2628781 ttcaccagcc acaacctctt tgtcgtatct gccgtgaatt gtgtcatact ttattaaatg 2628841 agccagcgtt tctgcggaat agctggcgtt aatggccact acttgaattt gatcgtctaa 2628901 catcgctttt ctaaaaacca ttcttccgat tcttccaaac ccgttgatcg ctacttttac 2628961 cttcatgttg gacacccctt atcaattatg ccatcctaat ttgttactat ctaaaattag 2629021 tataacacat taaaacaaat tcgccagtac atattgataa aaatcaacga ttataacgct 2629081 aatttatgat gcatcttatg ttttcttgca cagaatatca ggcgtaagaa ccaaaaagca 2629141 gccagcgctc cgcactgact gccctcatgc tttatgattc ctgttttaac ttatcattga 2629201 gcacactttc ttctagcaca gaaaatgtat ccccgtacac tctgttaata tgattcgctc 2629261 cccaagcaca cagcatatct aaaatccctt ctaagctgcg gccgtattcg ctgagctcgt 2629321 attccacttt gggaggaact tgattatata cgattcggtt aatgacaccg tccgcttcca 2629381 gctcgcgcag ctgctgagtc agcatttttt gcgtgatatt gggcattagg cgttttaatt 2629441 cacttgtgcg tttttttccg tgcgtcagat ggcataaaat gacgcatttc catttcccac 2629501 cgatcacttc aagagtcgct tcaacagaaa tgttatattt tttcttctcc atacaatcca 2629561 ttctcctcac aggcaccaaa aagtgactat agcacttcaa agtacgtact tttatttctt 2629621 aacgatatgt ttcataatca catttgccgg ctgatttgaa tctgctcttt tttatttata 2629681 tagcttactc ggcagaattt caatcataca acacatctta caaaggagga acatcatgac 2629741 ttcagccaat aaaagcaata ttcctgcact actggctttg gccgtaagtg cattcgcaat 2629801 agggacaact gaatttatca gtgtcggcct tttgccgctc attgctgatg acctggatat 2629861 tcccgtcacg acagcaggat tgaccgtttc cctttatgcg ctcggcgtta catttggggc 2629921 acctatatta acttcattga cctcaagcat gtcacgtaag acactattgc tttggatcat 2629981 gtttattttt attgccggta atacgatggc agcaaccgct tcaagcatcg ggattttact 2630041 agcagcacgt gtgatatcgg cattttcgca cggtgtgttt atgtcgatcg gttcgacaat 2630101 cgcagcggat attgtcccgg aggataaaag ggctagcgcg atttcaatta tgtttactgg 2630161 cctcactgtg gcaactgtaa ccggagttcc ttttgggaca tttatcggcc agcagttcgg 2630221 ctggcgtttc gcctttatgg tcattatcgc cgtcggaatc attgctttca ttacaaatgg 2630281 cattcttgta ccgtccaaat tacgaaaagg gacgaaaaca acgatgcggg atcaattgaa 2630341 gcttgtgaca aacagccggt tattgctttt atttgtcatt acagcgcttg gatacggagg 2630401 aacattcgtt gtgttcacgt atctgtctcc cctgcttcag gaagtaacag gcttcaaagc 2630461 cgggactgtt gcagtgattc tgctcggata cggaatagct attgctatcg gcaatatgat 2630521 tggcggaaag ctgtcaaacc gaaatccgat tgccgcttta ttctatatgt ttatcgtaca 2630581 ggcaatcgtt ctattcgtac tgacatttac agccccgtat caagcagcag ggctcattac 2630641 cattctctgt atgggattgc tggcctttat gaacgtgccc ggccttcagg tgtatgtcgt 2630701 catgctggct gagcgttttg tcccgagtgc agttgacgtc gcatccgcga tgaatatcgc 2630761 tgcctttaat gcagggatcg cgcttgggtc ataccttggc ggtgtgatca ccgattcaat 2630821 cggattgatt cataccgctt ggataggcgg attaatggtg gtcggtgcag tcattttaac 2630881 aggctggagc cgcttgatgg aaaaacgaga tcggcaggaa gcctgacaat tttaaaggag 2630941 gaaataaaca tgacaacaca tttacaagca aaagcaacac ttcataatgg ggtagaaatg 2631001 ccttggttcg gcctcggcgt gttccaagtg gaagaaggat ctgaactggt aaacgcagtt 2631061 aaaactgcca ttgttcacgg gtaccgcagt attgatactg cagcaatcta tggaaatgaa 2631121 gctggagtcg gagaagggat tcgggaaggc attgaagaag caggcatttc aagagaggat 2631181 ctgtttatca catcgaaagt atggaatgcg gatttaggct acgaagaaac actcgccgcg 2631241 tttgaaacaa gtctgtccaa actcggtctg gattatttgg atctatacct catccactgg 2631301 cctgtagaag gaaagtataa agaagcttgg agagcgcttg aaacgctgta taaagaaggc 2631361 cgtatcaaag cgattggcgt aagcaacttc caaattcacc atcttgaaga tctgatgacg 2631421 gcagctgaaa ttaagcctat gattaaccaa gtggaatttc acccgcgcct cacacaaaaa 2631481 gagttgataa gatactgcca aaatcagggc atccagatgg aggcttggtc acctttaatg 2631541 cagggacagc tgctggatca ccctgtattg gctgacatcg ctcaaacata taataaatct 2631601 gtcgcacaaa ttattttgcg ctgggatctg cagcatggca ttataacgat tcctaaatca 2631661 acgaaggaac accgcattaa agaaaatgca agcgtatttg actttgaatt aacgcaggat 2631721 gacatgaacc gaatcgatgc actgaatgaa aacttgcgcg tcggtcctga tccggacaac 2631781 tttgattttt aatggccaaa aaacaccgtt caatatgaac ggtgtttttt gtattatgcc 2631841 cagctgttca tgatttcatc aagctgcctt ttggtctctt caagcgtgcc gctgttatca 2631901 atgacttgat ctgctcttgc tgttttttcc tctaagggca tttgagagcg gatacggctg 2631961 actgcttctt cttctgtcag ctgattgcgc ttcatcagac gttccagttg aagctctttt 2632021 gtcacactga ccacaataat tttatcaacc aatgattcca atttgctttc gaacaatagc 2632081 gggatatcca atacaacaaa tgcctcccga tttgcaacgg cttcatcacg gcgattgagc 2632141 atttcctgcc tgactgcggg atgaacaatt gcatttaaag cgagacgttt ttgttcattt 2632201 gtaaatacca gcgctccaag cttttttcta tctatatcgc catttgagag cagtatgtct 2632261 tcaccgaatt cgtcaatgat ttgccggtag gccggcatcc ctttttctac cgcttgtttt 2632321 gcaatgatat ctgcatctat aactgttatt cctttttcaa tcagcatatt ggctaccgtg 2632381 cttttgccgc tagctattcc tcccgttaaa ccaatgacta aggtcaagag atccactcct 2632441 ttttacaatt tccagagccc aatcgtgatt aatagaagcc ccggcaaaaa cgccatttta 2632501 tcgatccatt tccacttaga cagaaaatgg ccggcattga ttccaattga tacaaacagc 2632561 gagctcatga ttgccacggc gatgctcatc acaatcggcg aaaaaccgag aatggctgcg 2632621 cctatacctg ctccaaaggc atcaatcgat aaggcaaatc ccaataagac cgcctcaatt 2632681 ccgttgatca cacccgattt gtcgatatcc gcactcatgg gttttctcaa aatatgaatc 2632741 acaattccta atgaccgaac ctctagatta agcagtgttt tttcatgcaa taggtattct 2632801 ttatcttttg ccggtttgaa aaattgatac agaacccacg caccgattcc aaccaatatc 2632861 aaaccgccaa gcttctccgt cacatataca ggaaaaaact tcgtgagaaa gcttccgatc 2632921 agcatggata taaacatgac agcaccggaa cagcaggcga taaccaaaat cgctttaaac 2632981 ggtattttca tttttctcaa tccgtacgta aatccgactg aaaaactgtc caagctgaca 2633041 gccaacgcca gcagcagtat agaaaccatt tgcatatccg tttcttcctt tctgttggtg 2633101 ctcttgtatc agatgtgaaa tgcccgggat tcatcacaat catatatatg ggaaagtgaa 2633161 aaatccgtgt ttcgaaaatg gcatccttaa tccagagtta ctgatatatg caccgacagc 2633221 ttggacaatg aagcattatg ctactttttt gtctggcact ttgcgcaaaa atgcgtgcct 2633281 cttcctccaa cgacaatttt cgaaatcatc gttccgcaat ttttgcatgg ctcgtctttt 2633341 tttccgtaca caaaatgctg cagctggaac attccgattt ccccttggga gttgatatat 2633401 gaacggactg tgcttccgcc cgcatcaatc gcctcctgca gagtgttttt gatttcagcg 2633461 tgaagggttt tgattgtttt atctgataat tgatttgctt ttgtctcggg atggacaccc 2633521 gctctgaaaa gagcctcatc cacataaatg ttcccgagtc caactaccgt tttttgatcc 2633581 agtagggcag ttttgacagc gcggtttgtt ttcgcaagcc ggtcttttaa atacgcactt 2633641 gtaaattctt ctgcatccgg ctccggccct aactgagaaa gcgggagctc gcccgcttct 2633701 tctcccggtt taaataagtg catggttcca aatttccgca catccctgta ccggagctgg 2633761 gttccatccg tcatcgtgaa tatgacatgc acgtgtttat cgtcaggctc ctcggcttga 2633821 tgaagaccgt attttccttc cattcgaagg tgagaaacca taacataatg atctaaatga 2633881 aacagtaaaa actttccccg tcttccgatg gactgtatcg tttctcctgc tagttttcgc 2633941 gcaaattcct ccggttcggc aggccgtttg atgatattcg gccatctgat ctctaccgat 2634001 ttgattgttt ttccctttac aagcccggtc agagtgcgcc ggaccgtctc aacctctggt 2634061 aattccggca catccatcac ttcctatctc tgtttatttc gcatcgtacc aagatgggcc 2634121 tgatgcaaag tccaccttta acggcacatc taatgcaagc gcatgctcca tcacttcagg 2634181 aacaagcttt tcaagaattt caatttcttc ctttggcgcc tcaaaaatca attcatcgtg 2634241 tacttgaagc agaagccttg ctttcaactg tttttctttc agcttggcag ccatgtcaat 2634301 catggctttt ttgataatat cagcggcgct tccttgaatc ggcgtattca tggccgtccg 2634361 ctccgcaaaa cttcggatat taaagttccg gctcgtcagc tcagggatgt agcggcggcg 2634421 atgcataagc gttgttacgt atcctttttg tttcgcttcc tgtactgaat cttccatgta 2634481 cgcttttacg ccttggaagc tttccagata gcggtcgata aatgctcccg cttccttccg 2634541 ggtaatgccg aggttctgtg acagaccgta atcgctgatc ccgtaaacaa tgccaaagtt 2634601 gaccgctttc gcctggcgtc tcatcgcaga tgtcacttca tccttagcga catggaacac 2634661 atccattgcc gttttcgtgt gaatatccat atcattagta aaagcttcga tcagattttc 2634721 atcctttgaa atatgggcaa gcacccgcag ctcgatttgt gaataatcgg ctgcaaaaat 2634781 gagccagtct ttttcagacg gcacaaaagc ttggcgaatt ttccgccctt cctcaagcct 2634841 gatcggaatg ttttgcaggt tcggatcagt cgagctgaga cggccagttt gcgttaaggc 2634901 ctggttaaat cgcgtgtgca ctttatgcga atccggtctc gtcaccttta aaagcccttc 2634961 gatatatgtt gattgaagct tgccaatttg tctgtactgt aaaatatagt cgacaatatc 2635021 atgcttgtca gccagctttt caagcacatc ggcagacgta gaatagcctg ttttcgtttt 2635081 ctttacgaca ggaaggccga tcttttcaaa taagatgacg cctagctgtt tcggagaatt 2635141 gatgttaaac ggctctcccg caatctcatg gattttttct tcatattcct tcagcttcgc 2635201 acccagttct tcacccatcc gttttaaacg gtcaacatcg accttgacgc cagttgattc 2635261 catttcgcca agaataagcg caagaggcat ttccagctct tcaaacagtt caagctggtc 2635321 gttgttttcc agctcttgaa cgagcttttc ccgaaggctt tgaatcgcta acgcttttcg 2635381 gccaaggtgc tcagacagta cgtcttctga cggcactgcc cgttttgctc cttttccata 2635441 aactgattca tcacttgaaa cgatatgcag gccgtaatcc ttagccacac tcgcaacgtc 2635501 gtcatatgaa ttgcccgggt tgatgatata agccgcaagg agcgtatcaa actcggctcc 2635561 tttcagctca atgccctgcc agcgcaaagc gacaacggcc cgcttgctgt cgaagaccca 2635621 tttcttctgc tcgtcatttt ccacccattc tttaaacacc tcagactcaa cggcaatgtc 2635681 tttcggaatg aaataagctc ccgtttcatt tacgatcgaa aatccgagga tcggctcttc 2635741 atgataatta tcgccaatct gttcaacgac aaatgcggat ggagaaacca atatatcgct 2635801 tgtcacgtct gtgactgttt tgacattaat gtcttccaac gattgatcct gttctgcttc 2635861 tgcactgtct tctccaagcc gttcaagaag cgtgttgaag ccaagatctt taaagatggc 2635921 aatgacctgt tcacgattaa agccttgata ttccaggccg gaaacagata cctcaatcgg 2635981 agcatccgtc ataattgtcg caagctcctt gctcatcaat gcctgatcct taaactcctc 2636041 aagcttttcc ttcaatttct ttccgctcac ctcgtcaatg gactccagca gcttttcaac 2636101 ggaatcaaat tgttttaaaa gcttaatcgc agtcttttct ccgacgccgg gcacacccgg 2636161 aatattatct gaggaatcgc ccatcagacc cttcatgtca atgatttgtt caggcgtaag 2636221 cccatatttc tctttgacat gctccggtgt gtaaaattca acatcggtaa ttccctttct 2636281 cgtaatggca actgtcgttt tgtccgttgc cagctgggtt aaatccttat ctcctgagaa 2636341 aaccttaact tcaaatccgt ctttttcagc cgatttggcc agtgtgccga taatatcatc 2636401 cgcttcatat tgttccagtt catagcggct gatctggtag gcatccagca gctcgcggat 2636461 aaacggcatt tgttcggaaa gctcaggcgg ggttttctgt ctgccgcctt tatattcttt 2636521 aaatgtgccg tgacgaaatg ttgttttccc ggcatcaaac gcaaccagca tgtgcgtcgg 2636581 tttttcatcc tcaagcattt tcatcaaaat catcgcaaag ccgtatacag cattcgtatg 2636641 aacaccttta tcattgctta acagcggcaa tgcaaaaaac gcccggtaag ccagactgtt 2636701 tccgtctaca agcactaatt tttttcgttc cgtcattcaa tttcctccta agaagcctca 2636761 ggcttccatt catctcttac atagtcatta gctcctctta ttttaacaaa gttcaatttg 2636821 aaaggaaaat acgtgaacta taagagaaga cacaaaaaag gacgggaaca caaataggtt 2636881 cccgccgtca aaattggctc cttggatgaa ggggttctac tacatcctac cagcataggt 2636941 ttaacagtgc atgaagatat tgttaaacct ttgtaaacat taggcggact tttcagcggc 2637001 ccgtttcagc gtcacggtaa agacagttcc ccgtccaagc tcgcttgtga catcaatttt 2637061 cccttcatga gcctctatta aatgcttgac aatcgctagg cccagcccgg ttccgcccga 2637121 atttctgctt ctgtctttat ctacacggta aaagcgttca aagatgcgcg gaatttcttc 2637181 tttctgaatt ccgattccag aatcggcaac ctcaatctga atgtcttttt ctctgggctt 2637241 tacattgata gccacggagc ccccctcagg cgtgtaggtt aatgcattgt ttacgagatt 2637301 aagaaatacc tgtttcagcc tgtacgggtc accagataca tattgagggt ctttcgggac 2637361 attcaggtgc aaggagatgc ctttctcatc cgccttatgc ttcagaagcg tttcaatctc 2637421 accaagcatt ttggccggct caaacgtttc gatactgagc gtgaaatttt gctgctcgat 2637481 ttttgagaga tcgagcaaat cctgaaccaa agactgaagc ctttcgcttt ccttaagaat 2637541 aatagagaga aattcagaaa gcgcctcttt gtcttccatc gccccgtcca ataacgtctc 2637601 cgtaaaccct tttatggacg taatcggtgt tttcagctca tgagaaacat tggccacaaa 2637661 atccttcctc atctgctcta atttcttcgt ttccgtcatg tcatggaaaa cgagcacaat 2637721 tcctttccat tcatcgtccg gccccataat cggaacgccg tccacttcaa aataacgccg 2637781 ttctattttg atcggcagtc ttaacagctt gcatttcttt gtctccgtca taaaaatgtc 2637841 ttcgacaagc tggatcactt cttcatgttc aaatgcatcg tgataaagac ggcgcagcat 2637901 atgattcgga ttgatatgaa actgcttggc gtaagacctg tttacgagat taataaagcc 2637961 tcttccgtcg atcataatca gcccggagcc aatgttttca atgactgtca gcagccgatc 2638021 ccgctgcatt tcctgcgttc gcgtcatttc catcagatca atggcaaggc tgttcatcgc 2638081 atgtcctagc ttatcagaac gcctaatata gccgccgtac gtccgtgcat cgtagttgcc 2638141 cttagagagt tctgtggcta catttgtcgc tgactcaatt gaccttttat aacgtgaggt 2638201 catgctggaa taaaaataaa caatgacgat aaatgcggta caaagactgg ccgtcagcat 2638261 cccccacaat tcgcctttta agccgtcgct tttttcagag gcggaaagca gcacatatcc 2638321 tgttttttca ccttcgcttc taagtgaaag tccgtaataa agcttgttat ctgttgttga 2638381 cagaataccc tcatggccag aaacaagcgc ctgcaccttt tgggaatcag ccgatctacc 2638441 gtttgaccca tacagcacct taccgtctgt atcgataacg gatgcgctca catcaagcgc 2638501 gccgcctgca tctttaatga ttttctcatt tgcttgatta ttcagattgc cggcatcaag 2638561 aagcgaagcc aagtattttg cttctttttc aatgtgttcc tctgctttcc tttgatcaga 2638621 tgtttcaaaa agctgctgta aaaacagccc gaggacacaa aacaccagaa tcatacagac 2638681 aacgaataca gaaaaaaggc gcacacggta tttattcatt catttttggc tcctccagtt 2638741 tataccccaa tcccctaatc gttttaatgt agatcggttt tttggtattg ttttcaattt 2638801 tgtcgcgaag atggctgatg tgcacatcaa caattctcgt atctccggca aaatcataat 2638861 tccagactgc gctcagcagc aggtctcttg tcagaactct gcctttatgt ctgcctaaat 2638921 agagcagcag ttcgaattct ttcggtgtca gttcaagctg actttcttta aagtacgctt 2638981 cataatgatc aggcaggatt ttcagatcgc cgattacgat ctggccttcc atttcatcgt 2639041 tcttcatctc actagagggc gcagctattt ccgaacgcct taaaatcgct ttgactctcg 2639101 catttacttc ccttggactg aacggcttgg tcatataatc atcagcaccg agctccagcc 2639161 ctaatacttt gtcgaattcc tcatccttcg ctgtcagcat taaaatggga aacatcagtt 2639221 tttgctgtct cagctgcttg catacttcga ttccgtccaa ttttggaagc atcacatcaa 2639281 gcacaatcaa atcaggtttc tctgtttccg cttttttgag tgcttcttcc ccatccgagg 2639341 cggtaatgac atcatagcct gaccgttcca aattgtactg taaaagagta acaatagatt 2639401 cttcatcatc cacaactaaa attttcttgt tcatgctgtg cctccagtat tataattccc 2639461 cgacatccta tttctctatt ttatgtcatc ttaacatgtt tcatgatttt attttagcga 2639521 aagcaggaca ttccgacaat tcgcctttta catcattttt aaaagaaata aagacgttta 2639581 tgatagcgct ttcatttata gtaaaaagag aaaggctgta ttaagcaagc ctttctctct 2639641 ttttattagg ataatacttt catgacattt ttgacagatt caactgattt attcagctgc 2639701 gctctttcat agtctgtcag ttcaagttca atgatttgct caagaccgtt gccgcctaca 2639761 attgtaggaa caccaaggta gatgccttca tagccgtatt ccccttcaag ataagcaatt 2639821 gtaggaagga cgcggcgctg atctttcaag atcgcttcga ccatttctgt cagagaagcc 2639881 gcaggcgcat aatacgcgct tccgtttcca agaagattca cgatttcgcc tccgcctttt 2639941 ctagtgcgct ccacaattgc gtcaatccgt tctttcggaa taagagtttc aagcgggata 2640001 ccgccagcat aagaataacg cacaagcgga accatatcgt caccgtgtcc gccgagtacg 2640061 aaaccagtca catctttcac tgacaggttt aattcctctg ccacaaatgt tctgaatctt 2640121 gccgtatcaa gcacacctga ctggccgatt acacgctctt tagggaagcc tgattctttg 2640181 tacaccgcgt atgtcattgc atcaacagga tttgtcagca ccacaataat agagtcagga 2640241 gaatatttca cgatttcctg cgtaacgctt ctcataatct tttcgtttgt agagaccaga 2640301 tcatctctgc tcataccagg ttttcttgcg ataccggctg taatgacaac aatgtcagag 2640361 ccggctgtat cctcgtaatt ggatgttccc gtaatttttg cgtcaaagcc ttgaaccggg 2640421 cttgcttcaa gcatatcaag cgcttttccc tttgtcgggt tctccaattg cggaatgtca 2640481 acaagaacaa cgtctgccag ctctttttga gcgattaaaa atgcagttgt agctccggta 2640541 aaacctgctc cgataacaga aactttttta cgagtatttc ccatgtctct cttctccttt 2640601 atggctagtt ttaggctttt tccttgctta gtccatgttt ttgatcagtt cttctccgaa 2640661 ctctgaacat ttcacttcag tcgccccgtc cattaatctg gcaaaatcgt aagttacgac 2640721 tttagaagcg attgtttttt ccatagattt gataaccaaa tcagccgctt cgttccatcc 2640781 taaatgctca agaagcagaa cgcctgaaag aataactgaa gatgggttta ctttatcaag 2640841 gcctgcatat ttaggagccg ttccgtgcgt cgcctcgaaa atcgcatgtc ctgtttcgta 2640901 gttgatgttc gctccaggag caatgccgat tccgccgact tgcgcagcaa gagcatcaga 2640961 aatgtaatct ccgttcaagt tcattgtcgc aacgacatca aactcgtttg gacgcgttaa 2641021 gatctgctga aggaaaatgt cagcaatgct gtctttgata atgatttttc ctgctgcttc 2641081 cgcttcgctt tgcgctttgt tggcagcgtc ttttccttgt tcttcagcaa tgcggtcata 2641141 ttgagcccat gtgaagactt tatctccgta ttctttttca gcaagttcat agccccagtt 2641201 tttgaaggcg ccttctgtga acttcatgat gtttcctttg tgaacaagtg ttacagattt 2641261 gcggccatgc tcgatcgcat aatcaatggc agctctgacc aagcggcttg ttccttcttc 2641321 tgaaacaggc ttaatgccga tacctgatgt ctcagggaaa cggattttat tgacgtttaa 2641381 ctcattttga aggaagctga taagcttttg cacttcttca gagccttttg catactcgat 2641441 gcctgcgtaa atatcttctg tattttcacg gaagatgacc atatcagtat cttcagggcg 2641501 ttttaccggt gacggcactc cagtaaagta tcttacaggt cttaagcaga cgaataggtc 2641561 aagctcttgt ctgagcgcta cgttcaaaga acggataccg ccgccgacag gtgtcgttaa 2641621 cgggccttta atcgcgatga aatattcgcg gatcacatct aatgtttcag cagggagcca 2641681 ctcacctgtt ttattataag ccttttctcc ggcgtaaact tctttccatg taattttctt 2641741 ttcgcctttg tatgcttttt ctactgctgc ttccaaaacc ttcgaagccg cgttccaaat 2641801 atcaggaccg gttccgtctc cttcgataaa tgggataatc gggttgtttg gtacgtttaa 2641861 tactccgtta gagactgtaa ttttttcacc ttgtgccaca ataaaaacct cccagtatgt 2641921 aattcatatt tagaaaacat tttatttttc ttatatagaa aataaaatga tttttcctaa 2641981 cattcaattt aaagtgtaac ccaattttga tgtctgaaca agaggctaac ctcattgacg 2642041 caagccagcc tccaatggtt ctttaggctc tttcttcaat cggaacgaat ttttgtttgt 2642101 cagggcctgt gtaatctgcc cgcgggcgga tcagacggtt gttgtcatac tgctcaagaa 2642161 tatgagcgag ccagccggac attctgctta cagcaaaaat cggtgtaaac aaatcatggt 2642221 caataccgag gctgtgatat acagaagccg aatagaaatc aacgttaggc ggaagctttt 2642281 tctctgatgt gacgatgtct tctatacgaa tcgacatctc ataccatttg ctttcgcctg 2642341 tcaggttggt caggcgcttg ctcatttctt tcagatgctt cgcgcgcgga tcaccatgct 2642401 tatacacacg gtggccgaat cccatgattt tttctttctt ttcaagttta gcgcggatgt 2642461 acggctcagc gttttccact tcaccgattt ctgtcagcat tttcataacg ccttcattcg 2642521 ctccgccgtg aagaggccct ttcagcgcgc cgattgctgc agtaatgcct gaatagatgt 2642581 cagaaagtgt tgcgacgcag accctcgctg tgaacgttga cgcgttcagc tcatggtcag 2642641 catgtaaaat caatgctttg ttgaaggctt caacttcaat tggtgaaggc tcttcaccgt 2642701 ttaatgtgta aagaaaattc tccgcaatac cgtaatcttc tctcggttca acaggctcaa 2642761 gacccttgcg aattctggaa aacgctgcaa ccaggccagg cacctttgcc tgaaggcgga 2642821 tcgcctttct gtagttggct tccgggttca tggtatcagc ctcgctgtca agcaggccta 2642881 gtaatgaaat tgctgtccga agagcagcca tgggatgaac attttcgagg gaataagatt 2642941 tgaagtgctc aataatttct tgcggaacgg cagcttcctt tgcaagctgc tgctttaact 2643001 cttcaagctc ttttttgttt ggcagcctta gatgccaaag caagtagatg atttcttcaa 2643061 aacttgcatt ctctgtcaaa tcatcgatat cataccccac atatgtaagg gtatcatcaa 2643121 taatagaact aacagatgat gttgttgcta caaccccttc aagaccgcgt gtcgctgtca 2643181 tatataacat ctccttttca ataaatttcc cctttaagag tgttgtaaaa acatgaggct 2643241 tacttaaaaa gcacgatgca agtatttctc tcccccaaaa agaaaatgct tacattttac 2643301 tggctgctgg aactaaaacc ctttgctttt gaaagaacat aacaaatttt tataagctta 2643361 tttaagttta agcctattct cattataaac aataatcaga catttgttaa atgtttacct 2643421 ataatttttt ttttccattc tgtgatttcc ccgaaaaaac gcctttattt gcgggttttt 2643481 gcataaaaaa aagcggcttt aaggccgctt ttttttatga agtgaacagt tttacgatct 2643541 gcatggctaa ataagcaatc cccgctccga tcagcggccc caccgcaact cctccaaaaa 2643601 gcgcgactgc aagaatggtc ccgatcacga gagcagttgt aatatgcgga tcattttcaa 2643661 gcagggtcag gccgtttttt gcaatcagcg ccactgcgat ccccgctcca agggcgatcc 2643721 atgcgtagga agaccgcatt gcttctccaa gctgcttaaa tccgatttct cccgtggcaa 2643781 tcgggacaag aacggcgatg gtaataatgg tcacacccca gttaatgcct tttgactgga 2643841 tggtcggaaa taatttctga tcaagcccaa cgattttgat gatcaaaagg acggatacag 2643901 caaagagcaa tgattggttt tttgcgataa gtgcgatagc caagagtaaa attaaaaata 2643961 aattcgcttg tgtaaacaca tgccatccct cctttaagat gaatgtattc atattcagcc 2644021 gcagcgtgaa tacatataaa aaataggaca tgctgacgag aggaggaccg tttttgtgaa 2644081 tcaatcttat atcactattt ttttcagaac cctctttgtc atatcaatga ccgcagggtc 2644141 gatagctgcg gcctattatt cgtttccgtt aacttatccg ttcctgatcg cccttattct 2644201 atcttcagtg attcatcctg ttgtcgatta tttggacaaa gtgacaggat tcccccgaac 2644261 gataaatgtt ctgggcgttc ttgctttttt tctgctcgca gccttcggcg tgctcaccat 2644321 tctggtagcc gaaatcgtaa cgggaacagc ctatctagca aaaacgctgc ctccgcatat 2644381 cagcacgttt atttcatatt gcgaaaaatt gtttaccact catattcagc cgctctataa 2644441 cgagttaact cttttgtttc aagaattgga aacgaaccag caggcttcca tcgtcactca 2644501 tatccagaca ctcggtgatt ctgccgctaa aaatgccggg ctcctgctgt cccacattct 2644561 agagatgatc ccgagatttt tcgctcttct tcccaatacg gcggcggttc tgattttttc 2644621 tcttctggca acctttttta tgacaaagga ttggcataag ctgaaagcca tgcttgtttt 2644681 aattctgccg gatcgtgtga cagctaacag caaagcaatc agcagcgaat taaaaaaagc 2644741 aatgactggt tttatcaaag cacaagccgt cctcgttttc atcacgatgg tgattgtatt 2644801 tatcggcctt tctctcttaa aggttgaaca cgccgcaaca attgcttttt taatcgggct 2644861 tgtagatctt ctcccttact taggtgccgg ctccgtattt gtgccctgga ttttgtattt 2644921 atcgattacg ggccagctgc cccaagcaat cggaattggt atcctgtacc tcgtcgttct 2644981 tattcagcgg cagctgacag agcccaagat actaagtaaa tctatcggga tcgatccgct 2645041 ggcaacactc atcgccctgt ttgccggctt taaattattc gggtttttag gactgattgc 2645101 gggaccggct gtactcgtca tcatccaagc tttcatcaca acaggcgcat taaaagaaat 2645161 atggtcctat atcaccgttc agcaaaaata aaacggcagc cgttttttca tggctgccgt 2645221 tttttatttg atgatgatcc gcttattctt cgacattcct ctcagccatt tgaacagaat 2645281 cggcttacac cagccgcggg taaacgggat aagaagacag gcgccggcca aatctgataa 2645341 aaagcccgga agcatcagca atagaccgcc aatgaaaatg cacagaccgt cagcaatcgc 2645401 ttctcccggc attttgccat attgaagatc acgctgaacc ttataataca cttcggttcc 2645461 ttgttttttt gcagctgctg cgccgataat gccagtcaga atcatgaata gaactgtcgg 2645521 caaaatacca atcagatttc ctaaaaatag gaatataccg atttctattg ccggaaacac 2645581 aataaaaagc aaaaacaaaa atctcatatc caagcccccc acacgtgtaa cacgttctgt 2645641 tcaacaaaag gcatgataaa gagaaaagga agggattccc cttccatttt cacctgtaat 2645701 taaagaacgc tcgcacggcc ttgatagact gcgcctctgg aagcgtcaac tgtaatatcc 2645761 tggccatctg tcaaaataga tgtcgcattt tccagaccca cgataaccgg gatgccaagg 2645821 cttaatccga ctaccgcagc atggctagtc aaaccgcctt cttctgtaat aagagcagac 2645881 gctttttcaa gggatgcaat catatcacgg tcagtgcttt tggtaacaag taccgcaccg 2645941 tcagtcattt tttgctcagc ttcttttgca ttttgtgcaa cgacaaccgg accgtaagct 2646001 gatttgcgtc caatgccttg gcctttagcg atgatatcgc cgacagtatg aaccttcatt 2646061 aagttcgtag tgccggactc accgacagtg ccagctgtaa taacgataag atcgccgtgt 2646121 tttacaattc cgctgttcaa tgatttttgg acagcatcct caagcatctc atctgttgag 2646181 ctcgcatttt ggccgctttc cgcgaatacg ccagatacga gggcaagctt tctggaaata 2646241 gagtcattta cagtaaccgc aacaatcgga gcctgcggac ggtattttgc aatcatacgt 2646301 gctgtatggc cgctttctgt cggcgttacg atcgcagcag cattcaggtt aatcgccgta 2646361 tgtgcgacag attgtccaat tgcgtctgta attgtcatgc ccacttggtc tctgcgtttt 2646421 gagagaattt ctttataatt taatgcttct tcagaacggg acgcgatgtt atgcattgtt 2646481 tgaactgctt caaccgggta acttccggca gcagtttcac cagaaagcat gatcgcatct 2646541 gttccgtcga agatcgcgtt tgcaacgtca cttgcttccg cacgagtcgg acgcgggttg 2646601 cgctgcatgc tgtcaagcat ttgtgtcgct gtaataacag gtttgcccag cgcgttgcat 2646661 tttttgatca gttctttttg cacaagcggc acttcttcag ctggaatttc cacacctaag 2646721 tctccgcgtg caaccattaa gccgtcagac acttcgagaa tcgcatcgat gttgtcaacg 2646781 ccctcttggt tttcgatttt agggatgatt tgaatatcct gagcgttgtg ctcttcaaga 2646841 agctcacgga tttcgagcac atccgtagaa cgtcgaatga aagatggtgc gatgaagtct 2646901 actccttgct caataccgaa aacgatgtct cgcgcatcct tttcagtaat ccccggaaga 2646961 ttgacactta cgcccggtac gttaacacct tttttatttt tgagtgttcc gttgtttaat 2647021 acttttgttt tgatttcgcg tttagcggca tctacatcaa gtacctcaag accgataagg 2647081 ccgtcatcta acagaatcgt tgaaccttgt tcaacgtcat ggactaaacc ttcatatgtc 2647141 actgaaattt tatctgttgt tcctacaacc tcgtccattg aaataatgag ctctttgcct 2647201 gtttcaagct caataccgcc gttttccatt gtatgtgtgc ggatttcagg accttttgta 2647261 tcaagcagaa ttccaacgtt cttgccaagt tttttacttg cttcgcggat atttttaatt 2647321 cttgcaccgt gctcctcaaa atctccgtga gaaaagttta atcgagccac gttcattcct 2647381 gactccatta atttcgtaag catttcaata ctttcacttg ccggaccgat ggtacaaaca 2647441 attttagttt ttctcatttg gttcacttcc ttctgaaatc ttcagccttc agctgtacat 2647501 tagatagaca gttcttttga aagctgatac atgttttgct caactgtgtg ttttgtctca 2647561 agtatttcta taatatcatg gtctacaagc ttattgtttt gtatacctac acagcgtccg 2647621 ccttttcctt caagcagcag ttcaactgca tatgcgccga gacggcttgc caacacacgg 2647681 tcagcagcac tcggagaacc tccgcgctgg atatggccca atacagatac cctagtttca 2647741 agatttgttt cttcttcaat gcgtttcccg aattcaacac cgctgcctac accttcggca 2647801 acaataataa tactgtgctt cttgccgcgt tcgtggccgc gttttaagcg ggcaatgatt 2647861 tcgtgcatgt catagtctgc ctcagggatt aagatcgatt ctgcgccccc tgcaagaccg 2647921 gcccacaatg cgatatcgcc ggcatgacgg cccattactt cgattacata tgtacgttca 2647981 tgagaagtcg ctgtatcgcg aatcttatca attgcgtcaa ttactgtatt taaagctgta 2648041 tcgaaaccga ttgtaaaatc agtgcccgga atgtcattat caattgtacc cggtacacct 2648101 acacatggaa acccgtgttc cgttaatttt ttcgcaccca tataggaacc gtctccaccg 2648161 ataacaacaa ggccttcaat accaagcttc ttcaagtttg ctatcccttt ttcacggcct 2648221 tcaactgttt tgaattcagg acatctcgcc gtataaagct tagtccctcc acgatgtata 2648281 atatcgccta ctgatccgag ttcaagcttt tcaatctttc cgctgatcaa tcccgcgtat 2648341 ccgttgtaaa taccgtaaac ttcaacgtca tgatagatcg cttttctgac tactgcgcga 2648401 actgctgcgt tcattcccgg ggaatccccg ccgctcgtta atacccctat tcgtttcatt 2648461 ctccattcac ctcagcaaca tatatgatta aacataacat gatcattgcc ctaaaaacaa 2648521 tgaaaaggga tctccatcct ccctatgaaa ccttacctat tatacaatta aataaattgt 2648581 ttttaaataa aatttaagga atgtcacaaa aaataaacgt gagccaaagg cttcacgttt 2648641 atttagttta ccccgatata ttgatcttca accgagactt tgccaattgc tttatatttt 2648701 tcataacgct gctgaactaa ttcttcttcg ctcagcttca gtaaagtttt taacgattgt 2648761 ttaagggttt cgtccatata gcttgcctgc agcttcacat catggtgcgc tccgcctttt 2648821 acttctttaa tcatatgatc tataatacct aattctttta aatccggcgc agtgattttc 2648881 attgtttctg ctgctttttt agcaagactg gagtccttcc ataaaagtgc cgcggcacct 2648941 tccggagaaa taacagaata agtagagttt tccagcatat gcaagtgatt gcctacaccc 2649001 agaccaaggg ctccgccgct tccgccttca ccaatgacga tgcagataac aggcactcga 2649061 aggccggcca tctcaaacag gtttttggca atagcttcac tttgtcctct ttcttcagct 2649121 gctcgtccag ggtatgcccc cttcgtatca ataaaacaga taattggtct gttaaatttg 2649181 tcagcctgtt tcatcagacg aagcgctttt ctgtagcctt ctggatgcgg catcccaaaa 2649241 ttgcggacta ggttttcctt cgtgtctttg ccgcgctgat gcccgattac cgttacaggg 2649301 aggccgtgga acttcgcaat cccgccgaca atggcttcat cgtccccgta cgctctgtct 2649361 ccgtgacatt caaaaaagtc ggtaaacagg tgttcgatat aatcaagagt tgtcggacgg 2649421 tccgccagac gcgcgatttg aacccggtcc cacggcttca aatttttgta aatatcatcc 2649481 tgaagcttag cgagacggtc ttcgagccgt tcgatttccg cacttagatc catatcggaa 2649541 tcttgggtga atttttttag ttcggcgatt ttggtttgca gttcaatcac cggtttttca 2649601 aattctaatc ttggagccac tcaatgtcac ctcctgtttg atgcatatcc agcagatttt 2649661 ctaacgtttt tttcatatcg tcgcgatgaa taaccgcatc aagctgtcca tgttttaata 2649721 aaaactcagc cgtttggaag tcctcaggca gtttttctcc tattgtctgt tcaataatcc 2649781 gtcttccggc aaaaccgatc agcgcgccag gctcagcgaa attgtaatcg ccaagggatg 2649841 caaagcttgc tgatacgccc ccggtagtcg gatgcgtcat tactgaaata ataagaccct 2649901 gttcttcact gaacagtttt aacgcagagc ttgtctttgc catctgcatc aaacttaata 2649961 cgccttcctg cattctagca ccgcctgaag ccgtaaaaat aataaacgga actttatcag 2650021 cttttgcttt ttcaatcgca agcgtgattt tttcaccgac gactgaaccc atgctgccca 2650081 ttctgaatga agagtccatg acggcgacaa cagccgggtg tccgccgatg gtgcccttgc 2650141 ctgtcacaac agcctcgttt aaggatgttt tctcgcgatc tttttcaagc ttttccagat 2650201 atcccgggaa accaagcgga ttttccgaga gcattccctg attaaattcc tcaaaggatt 2650261 gttcatccat caagctttcg atacgctgtt ttgcgttcat tgggaaatga taatcgcagt 2650321 tcatgcatac ccgcatattt ttatccaact ctttagtgag catgattttt ttacacttag 2650381 gacattttgt cataatgcct tccggaacat cgtgcttcgc ttgatcagac ggtacggaag 2650441 catacttttt ctttttcgtg aatatatcct ttaacaaatg attacctccc ttttgtgaag 2650501 ggttctcttc accgcatgtc atcaaacaga tagacttgct aataacttta ccgaaactat 2650561 tgtacttttt ttgtcaaacg ctgtcatcct caattcgaca actttttatt cgatgacgtg 2650621 ctcggaaagg cttgtatgaa atcagataag gtgttgaaac gacaaggttg acagcgcatt 2650681 caaaaataat gttaaacccg gctgaaattt ttttaaggct aaccccctaa aaaaatttca 2650741 gccgtcagtt taacttgaga acagcgcgcc ggtctccgcc aacgcgctgc catttttgga 2650801 atgaattaaa attattcacc aataatcgta agttttcttg ttttttctgc gacttcctca 2650861 gggtcaacag tgattcttgc aacacctgtt tccatcgcag cttttgccac agccttcgca 2650921 acagcaggcg caacacgttt atcaaacggt gcagggatga catagtctgc gctaagctca 2650981 tcttctgaaa ccagtgaagc aatggcttca accgctgcga ttttcatttc ctcgttaata 2651041 tgagtggcac gcacatcaag cgctccgcgg aaaataccag ggaatgcaag aacattgttt 2651101 acttggttcg ggaagtcaga acggccagtt ccgacaacgc ttgctccggc ttcacgcgca 2651161 tcttccggca tgatttccgg atttggattt gccattgcaa agataatcgg atcttttgcc 2651221 atgctttgaa ccatttcttt tgttaacgcg cctgctacag agacaccgat aaatacgtca 2651281 gcatcaacga taacatcttt cagagaaccg tctttgcgat cttggttcgt gaacttcgcc 2651341 acttcatttt tgacatcgtt catgccgttc gggcgccctt cataaatggc ccctttggaa 2651401 tcgcacatca caatgtcgcg aacgccataa tgatgaagaa gcttgataat cgcaatgcca 2651461 gccgcacccg cgccgtttgc gacaacttta atggatgaca tggattttcc agacagtttc 2651521 agcgcgttca caagacctgc tacggttaca atggcagtac cgtgctgatc atcatggaaa 2651581 accgggatgt ttgtttcttt tttgaggcgc tcttcaatga taaagcagtt tggcgctgca 2651641 atatcttcaa ggttgacgcc gccaaatgtc ggttccagca attttacagt ttcaacgatt 2651701 ttatcaacat cgtttgtgtt taaagcaatc gggaacgcat ctacgcccgc aaagcttttg 2651761 aaaagaactg ctttcccttc cataacagga agcgccgctt cagggccgat gtttccaagg 2651821 ccaagcacag ctgtaccgtc agttacaact gctaccatgt tccccttcat tgtataatca 2651881 tatactttgt taatgtcttc atgaatatcc ttacacggtt ctgcaacacc cggagaatac 2651941 gcgaggctta aatctttcgc atttctgacc tctacttttg atttagactc cagtttcccc 2652001 tggttgactt tatgcaggtg taatgcttct tctcttaatg acattctcct aaacactcct 2652061 tatggatatt ttttgattcg tatactgctg cgttgattgc tgcattctgc ggagtaaatc 2652121 tatctgaata tttaaacagg atcacataat tgctccaatt gtataacaaa aagcgaatcg 2652181 ttaccactgt tttaaaacga cgtttttttg acccaacagc tcttttaagc gatataacac 2652241 ctggtgatct gcattgatat ggaacgactc aggtagctta atcgtctgtt tttgcctttc 2652301 ataatagaga taaacgcctg tttccccttt atgctccagc aaaatgcgct taatctttgc 2652361 caggatctcc tggctgtgct gactgctttc tatttttata taaaccgatg gcgctttttc 2652421 tgcatccata tcttctaata attctgcccg ggacatgatg aattggatct tatcttgtct 2652481 aacttcacat ttccccgcag tgaacaaaag agcgccttct cttaaaacgg gagaaagctg 2652541 tctgaattgt tcagggaaga ctacggcttc catctcgccg gtttcatcac tgagcgttaa 2652601 aaacgccatg ttttgacctg ttttcgtccg aatcgttttg atcttcgaca gcagaacgcc 2652661 tagtgaaagc tgccttttga ctgcccgctg agcctgcaga atggagactg ctccttgcgc 2652721 agtgagctgt tttcggaagg cggagagggg atgatttgaa aaataaatgc caagcgtttc 2652781 cttttcaaac gcaagtaaat ccaccagagg aagctcctcc gtctccacat acttcggctt 2652841 aattgaaaac gattcatcta aaaacaatcc catttggtca tcgtccgcgg cgaatagctc 2652901 agcatgttcc aaagcaacat caatggatgc gagcagcgtg gcccggtttt ggccgaattc 2652961 gtccatcgca ccagaaaaga taagtgcttc aagcattttg cgatttacgc tttttgacgg 2653021 cacgcgaaag cagaaatcga aaagatcttc aaatggtttc tcttttcttg ctttatatat 2653081 atctttgact gctgagacgc ctacactttt tatcgcgcgg aggctgtatc tgacagatcc 2653141 gttttcaact gtaaacggaa aactgctttt attcactgac ggaggaagga tacgaatccc 2653201 gctccccttt gcttcgtaaa gatattgaga gattttatcc tcattgccaa tgacgcttgt 2653261 cagcaatccg cacataaaat ataacggata atgagctttc aaatacgcaa gctggcaccc 2653321 gatcatgctg tatgccaccg catggcttct gttaaagcca tagtttgcga atttgacgat 2653381 taaatcgtag acctcatttg cagtgtctac agaatactcc ttttttaagc acccttcaac 2653441 aaaatggctt cgctctctgt ccaggatttc ttttttcttt ttgctgaccg cccttctcaa 2653501 taggtccgct tcgcctaaag aaaaccccgc catacgggaa gcaatcatca taatttgttc 2653561 ctgatacaca atgacgccat atgtatcttc caaaatgctc cttaaatctt catgaggata 2653621 gtgaacaggc gcccgaccgt gtttacggtc gataaataac ggaatatttt ccatcggacc 2653681 cggccggtac agtgcattga ccgccacaat atcttctagg cccgaaggtt tcagccgttt 2653741 caagacgctt ctcatccctg cagattcaag ctggaaaatg cctgtcgtat ccccttttga 2653801 cagcaaggag aacgttttgt catcgctgta ggaaatactt gaaaggtcta ttttaatatt 2653861 ttcttctttt tcaatcattg aagtgatgga ttcaataagt gtcagattcc tcaaacctaa 2653921 gaaatccatt tttaaaaggc ccaagtcttc aagatggtcc atcgcgtatt gcgttaaata 2653981 gatcccttca tgcccttctt gaagcggaac aacatctgtt aacggttctt cactcaggac 2654041 aacgcccgct gcgtgggttg atgcatgcct tggcagccct tctattttcc gggcaattga 2654101 atagacttgc tgaagcaggc ttgactcccg aagccgctta tccagctgcg gtgactgctg 2654161 tctcgcttca tccagcgtca ttcccggtct tgaaggaatg agttttgcaa gctgatctgc 2654221 ctccttcggg ctgacgccga atactctgcc gacgtcccgg agcgccgcct ttgccgcaag 2654281 tgttccaaag gtgataatct gtgcgacgtg cattgcaccg tatttctgct gaacatattg 2654341 aatgacttca tcccttctag tatcgggaaa gtcaatatca atatccggca tgctgacgcg 2654401 ttcgggattt aaaaatcttt caaacagaag gtgatgctta atcgggtcaa catctgtgat 2654461 atacagcaca tatgccacaa gagaacccgc cgcagaaccc cttcccggtc ctgtaacaat 2654521 ccctttttca tgggcgtgct tcataaaatc ccacacgatc agaaagtaat cgctgaactt 2654581 catccgcttg atgacatcaa gctcatattg aagacggcga aggtatcgtt catcaggctt 2654641 gccgaaacgg ctgcggagtc cctccataca gatatccgtt aaataatcat cagcggacgt 2654701 tccgtctggg gtcggaaaag acggtagacg ggtctgcccg agactgacgt caacccggca 2654761 ttgttccgcg atctctacag aagcttgcag tgcctcggga tgctctcgat aaatgttttg 2654821 catttcttcg agtggtttca aatcgagatc aggcaaatct tcagcgggtg catccgtcag 2654881 tttttccccc gctttaatcg ctttcaaaca acggtaggca gccttatctt ccttccttat 2654941 gtaatgcaca tcgcctgtgg ccgtaacagg gatacccgtt tcttctgaca gctttagaat 2655001 ctgctcagac aagacttgat tccctttaaa aggctgatag gagaaataaa aagctccctt 2655061 tccgaatata gactgaaatt ccagcgaggc ttgagcagcc tgttcgaaca gccctccttc 2655121 aagaagcgtt tcaatatatc ctttttcgcc gggcgttatt gcgataatcc cttctcgata 2655181 actgtgaagc catttcggct tcagtccgcc ttttgattta gattgcagaa cgctgctgat 2655241 tttcagcagg ttttgatagc ctgtattcga ttttgccagc aggacgagcg ggtatgcttc 2655301 aagctcgctg tcatctgtaa aaacagaagc cgtcaaaccg attattgggt tgatccctct 2655361 cgccttgcaa gctttataaa attgaatagc tccgtacatg acatgatcat ctgtcagcgc 2655421 caaagacgca tatccgagcc tgtcagcttc actgacgagt tcttccacag ccgcggcgct 2655481 gtttagcagg ctatacccgc tatgcacttg caggtgaaca aaagacatgc tatcacctct 2655541 ttctcattac gatccatttc ttccttcatt ataaggccgg tttccaaaag aaacaaatgt 2655601 tcttttttga ctcatcatca tacttgtcct gaaagctcaa tatgatataa aaggtgaggt 2655661 gataaagatg gatcaggaag caggatttat ggtgaatttt atcaatagct acttcattgc 2655721 gttaggggtg ctgatcgggg gcgcactcat cggagggctc ggagcatact tggcaggcga 2655781 acccccgctt acagccatta caaagcttgc caaccggtta aaaatatggg cgcttgtcgc 2655841 agctatcgga ggcacctttg atgcggtata cagctttgaa cgcggcatac tcgaaggcaa 2655901 tacgagagat atctttaaac agcttctttt aattatttcg gccatggggg gcgcgcaaag 2655961 cggctggctt attatatcat ggctgaccca ggagcatctt tcttcatgag ggtcccccag 2656021 cattacaaaa aaccgggatg gcagcgtttt ttcgcgggaa tgatgtgcgg agccgtaatc 2656081 agctggttct ttttcctgtt tacttacgga acattccaag aggagcaggt cagcctcatc 2656141 gaaaagcaaa aagagcatgt aaaagacttg aacaatcaaa tttcgatcta tcaggaagac 2656201 ctccataaac tgaatgaaga taataaaaga aaactgctga ttcaaagcgt cagcgtcaaa 2656261 ttgctgaatg gggataaata taaaatatca cagccggata aaacgaaatt cgaggagcat 2656321 gtaaaggatg atatttcaga ggtgattaca aaagacatag agagcgtcta tcaaacaaag 2656381 gatctcttga agcggacaat tgaaaataaa gtctatatga tcaatgaaaa aaaatacgag 2656441 gcaaccgtca gagaattgat tatttatacg aggctgacag tggaacttga aatttctttc 2656501 gccacataat tatggatttt ttttaaattc tccaaacttc tgtcgctttt tcccattctt 2656561 ttttataaac tatatgtgag gcttaatggc gaaaggaagg aggaagggaa atggaggttt 2656621 acagtgaccg tcagttagca aaagatcaag cagcccgtct cagacaaggt ttttctgcat 2656681 atgccgaaac aaactcactc gcttccctca tcaaaaaaga acttcaatca cacaatctcc 2656741 aagtctacga ggaccttact gatttcggct gctggttcat ccccgtcaca gatgaacact 2656801 aagagagagg gtctcccctc tactcgtgtt ctttacataa tgtttccaga tcagctaaaa 2656861 tacgatcagc ttcatcccag ctgtaaatag aggcgcctga agctaacgga tgccctccgc 2656921 cgttatattt ccgggcaagt ccgttaatga caggcccctt cgaacggaat ctgactctga 2656981 tttgatcgtc ttcttctacg aaaaacaccc aggcgcgaat acctgagata ttgccaagcg 2657041 tcccgacaag ctgcgacgct tcagaagccg ttgtgccgaa tttttcaagc gtatcctttt 2657101 tgatgaaaac agaagccgcc ccgttttcgg acaaagacac attttgaaag ataaagccgt 2657161 taagcttcac cacattcagt tttgtttcat acaattgatt aaataactct gaggaagaga 2657221 atggatactg aatgagctcg cctgcatatt ttagtgtttt ttccgtggta ttcggaaata 2657281 aaaagcgtcc ggtatctcca acaatgccgg cgtagatcag ctctgccgct ttcgtattca 2657341 gcttccagcc gtgctctttt ccttctaaat acagctcgta aatcatttca cttactgagc 2657401 tggcgcttgt atcgacccag agaaggtcac cgtatggatc ttcgttcgga tggtggtcga 2657461 ttttcattag tttggcgcct gaaggataac gctgatcgtc gattctttcc tgatttgccg 2657521 tatcgcagac aatgacaagt gcgccttcat atgtttcatt gtccacctca tcaagggaat 2657581 ataagaaaga gagggacggt tcaggcgtgc cgaccgcaaa aatatttttt tcaggatatg 2657641 tttcacgcag gatttccgta agcccacact gtgatccgta ggcatccgga tcaggacgca 2657701 catgtctatg taagataatc gtgtcatata atgatatggt tctgatcaat tctgttttca 2657761 tttgatactc ctttattgtt tttattcatt aaatcacatt ctctgccgac ggaaaagaaa 2657821 aataacgtca aaaccaagcc cgtttttgta taaaatgggg ttgtaaactt ttacgatgga 2657881 ggatttcatt tatgctggtt cttgtttttt tgattgggct ttcagcctgc ttttatgtgt 2657941 actataaagt aaaaggcgta cgggcaaagc catctttggc aaaagaaata tgttcagcaa 2658001 aatcaagcat ggccttaggg tcactagtcc tgttctacgg gcttaaccaa atgatattat 2658061 tccattcagt attaacgtta gtaatcggcg gtatctttat cgtcatagga gcaggaagcg 2658121 cttgggcagg ttataaagcc ttcaggcatt acaatcccct tcacgccaaa gaagctgaaa 2658181 gagatcacgc gtaaggggcg cctgaacgtc ccttagcttc tttccatcag ctgaaccatc 2658241 agcatcgctt tagacacgat atgaccttgg ctgtgcactt ccacttccat tttcccaaac 2658301 tttctgccgg cctccaagat gcgaggtttg acttcgatga ctgattccat ctgcacaggc 2658361 ttcaaaaaga agatggtgat gctctctatg acgagttcgc cgcgtttttt cgagcgcaaa 2658421 aatcggtttg ccgcttgcgt caaaatggtc gtaaatacgc cataagaaat ggttccaagc 2658481 tgatttgtca tttgcggcgt gacttcatac tcgtaaaccg tttgatcttc tttatcatca 2658541 ccctcatctt taaaccccct tgaaacgata tcatcaagct tctccccgac ctgcggctgc 2658601 ttttgaatca tttgaagagc tttcaatacg tcttggcggc tgatcatgcc gatgagtttt 2658661 tggtggccgt cagtgacggg aagcacttcg atcccttccc ataccatcat ttgcgcagct 2658721 gaagcgacag atgttttccc aataaccgtg acgggatttt tggtcatgac tttttctata 2658781 gatgcatttc ggtcatggcc agcaatatct tttgatgtca gaatgccatg gattttcatt 2658841 tgatcgtcga caaccgggaa gcggccgtgc cccgtttcaa aatttttctc ataccatttt 2658901 tcaagtttat ccttaggcga aagatatacc gtgcggtcag caggtgttag gatgtcctcc 2658961 accaaaacaa tttctttttt gatcagctgg tcatatattg cccggttaat catcgcggca 2659021 actgtaaagg tgtcatagct cgtggataaa atcggcagtt caagctcatc tgccagctgc 2659081 acaatgctgt catccgtgtt aaagcccccg gtcaccaata cggccgcgcc cgcttcaagc 2659141 gcctgcctgt gtgcattgat tctgtttccg acaatcaaaa gattccccgc tgcggtgtaa 2659201 cgcatcatcg cgtcaagctc catcgcgccg atgacgaatt tattcaatgt cttatggagc 2659261 cctgccctgc ctccgagcac ttgtccgtct ataacattta caacctctgc ataggtaagc 2659321 ttttcaatgt tctctttttt cttttgttca attctgattg tgcccacacg ttcaatcgtg 2659381 ctgacaaacc ctttattctc tgcttccttg atcgctctgt acgcggttcc ttcgcttact 2659441 ttcatttcct ttgcaattct tcggacagaa attttttcac cgacaggcag tgaatcgata 2659501 tacgttaaaa tttgttcatg cttcgttgcc aagcctttca cctctaagga cagtcttctt 2659561 gtttttatta taaggtttca aaggatttat acgcaatgag gctggaaaat aaaaaagaag 2659621 cccgaccggc ttcttacagc gttgatttcg ttccagtcaa acgcaaggac cacgtgattc 2659681 cttttacatc gtaaagcgga aaaaccttta tttttctttt aaatggacat caaccgctgt 2659741 cttaacaata tttcgattcc ctattttaga taaaacaaat aaaactgcgg atagccatat 2659801 cgcccctatg gccgtataga tcaatggatg aacagctgtg tttgcgatcc attcatttat 2659861 taatgttctg gcatttacca gaataataaa tcctcctaca agcacaccca tcaattgcgg 2659921 atgaaacttc tgcaccagcc atgctgcgat aggggcagcg ataattccgc cggccattag 2659981 tgaaaacacc cataaccaat tgacgtcctc ccatcctaat gaaataagaa aaccggcggt 2660041 tgcagatacg gcgatggcaa attcacttgt gtctacagtc ccgacaactt tcctcgggct 2660101 caagcctttg cgggataata aaatcggagt ggtcaccggt ccccagccgc ctccgcctgt 2660161 ggcatctgca aaaccagcga tcactcccaa tgggatggat tgttttcggt ttaacggcac 2660221 atgcttcttc tcaagagccg gcttatattg aaataaaaac ctgatcaata catatccgcc 2660281 cagaaggagc aaaaacaaag aaatataggg tttcgccaca tctccaggta attggctgag 2660341 gaatgccgcg cctaaaaaag cgcctataga gccgggaatg acaagctgat aaacggtttg 2660401 tttgtcaaca ttgccaaatt taatatgcga cactcccgat gcggcagtcg ttacgacttc 2660461 cgctaaatgg acagaagccg aagccacagc aggtgtgatg ccaaacgcca ataacaaaga 2660521 agttgaggta accccataag ccatacctaa cgaaccgtct attaactgcg acaataaacc 2660581 aataaatgca aaaacgatta atttcttcat cagaacaccc catctatatc aatcagatat 2660641 ttttgactct tcattcgaat ctaacaatct cttggcgctt tcatataaaa aataagaggc 2660701 tttgataatt gcagtttcat ctattgtaaa tgcagggtgg tgccaatcat gatcaccgtc 2660761 tgttccaaaa aacgcaaagg atcccggaat atgctcaaga taataagcaa aatcttcccc 2660821 cgcggttgat ggggcgggat caatgacttg aagtttcgct ttatgtgcag cgtctcgcac 2660881 cagccccgta attgcctcat cattacaaag cggcggcggt ccggaatgcc acttcacatt 2660941 tgcctttaac gagaaagcgg cagaaatctg ctctgtgact gcaaaaaaac gctgtttcac 2661001 ttgattacga acctctgaat caaatgtacg aacagtgccc tcaatgacca ctgtatccgg 2661061 aatgacattc caagtgctgc cgccgttgat tttccctacg gttaaaatcg cgctttgcag 2661121 cgggtttaca tttctgctta caatcgtttg cagggcgaca ataagctgag aggcgccgat 2661181 aattggatca aaaccattat gcggcaatgc tgcatgagca cctttccctt ctatctctac 2661241 tttaaatcgg tcaacagcag ccataagcgg gcctgttttt aaccctacag tcccaaccgc 2661301 gatatccggt ttattgtgaa ggccaataac cgcatcaatg ccatccagtt ggccgtcctc 2661361 tatcactttt gtagcgcctg cacccgcttc ctctgctggc tgaaataata aacgaatctt 2661421 tcctttcaga ctgtcttgat tttccttcaa taaaaaggcc gcaccaagaa gcgctgccgt 2661481 atgaaaatca tgaccgcacg catgcatgat ccctttatgt ttagacgcat aaggcaatcc 2661541 tgttttttct tcaattggca aggcgtcaat atcagccctc aaagcaatcg ccggaccttc 2661601 tgactcccct gctatgtctg cgaacacacc cgtttttaga gcagtagggc gaatctgtat 2661661 ccccttttct ttaaggcatt tttttataaa agcagttgtt tcaaattctt cttttgacag 2661721 ttcaggatat tggtgcaggt gccggcgaat gccgatgagc tgcttttcta gcgttgagag 2661781 atttacggga ttagactcct ctttcaacgt caggatgtca tttcctgtag tctgatatgg 2661841 ataggagcct tctatatttc tccaataatc caaagacata tgttccgctc ctttccctat 2661901 cccaatatat tttcttcaga ctcttcaaca taagatgaaa taaatcggtt caatttatca 2661961 gcaagaccgc ccgccccaaa tcttatatac ttgctggaaa ctttcggatt atcttctttc 2662021 aaaaagctta aaaaagataa aatataaatg cgcctgtaag ctacttgtgt aattccgtac 2662081 tcaaaaaacc agttatcaat gacattgtat acgcctcggt tgacgccata taggttatta 2662141 catttcttgt aaaagcagag atccggaaga tttaactcct gatgggaaag aaggctttct 2662201 tttttgtttg gtgccataat cccaatcagc tcaaagcgtt ttgcaacgca cgaaatatcc 2662261 tttttaattt gctttgttaa agactccaaa gaatcaaacc ttctttcttc tctaatttta 2662321 aagagaatgc tgcattcgat tttttctcca taaatgtctc tatgaaagtc aaacaaaaaa 2662381 atctccaatg tcttttcaag gttagagccc accgtcggtt tcacaccgat attcataacc 2662441 cctaaatgaa attgatgatt gactgtcgcc agaaccccat aaactccatt acgcagccca 2662501 tgtatttttg catctacatt tgccgtgggg aatccaagct ttctgcctaa ttgttttcct 2662561 ttcacaaccg taccggcaat gatcgtcaaa aaagtcagcc tcctctctca gcttccgcat 2662621 tcgatcagac gaaacctaat gatgtgatga atgtaaaacg gattgatgct gcggaatgcc 2662681 aagaccgaga ttttcccgca atgtcccgcc gcgataatct tgacgataaa gccctctttc 2662741 ttgaagaatc ggaatcacct tttctacaaa agcatcaagt gttcccggta tatccgaccc 2662801 aacgataaac ccatccgccg cctcagcgtt gaaccaagtt tcaattaagg atgcgacacg 2662861 ctctggtgtt ccgatgaata gagtccgtgg aaaagccatt tcctgtgcta cctcccgcaa 2662921 tgtcagattt ctggcttttg cttctctctt aatccggtct gttgtgcttt gaaacgcatt 2662981 ctttcccaca tcgccaatat cgggaaatgg ctcatccaac gggtaaacac tcagatcata 2663041 atcatcaaaa aaacgggcca aataagtaac agcattttca atcggtatca attctgcaaa 2663101 ttcacgatac ttcttttccg cctcttcttc cgtatctgcc acaatcgggc tgatccctgg 2663161 aaaaatccgc acacttgaag gatcacgccc ttcatcagca gctcggcttt tcacatccgc 2663221 ataaaacgct tttgtctctt ctaatgaatt ggaatgggta aaaatcgcat ccgcattttt 2663281 agcagcaaac tgccggcctg tttctgatga acccgcttga aacactacag gctctccctg 2663341 cttagagcgc ccgatattca agggcccctc tacttgaaaa tactttcctt tatgattcag 2663401 gcgatgaagc ttcgcctgat cgaaaaactg ccctgttttc ttattgtgta taaatgcgtc 2663461 atgctcccag gaattccaca gcccgcgcac aacatccaaa tgctcttgtg cgatctcgta 2663521 acgttcagtg tgttctggca aattagactt actatggttg cgcgccgctc cttcctgcgg 2663581 cgaagtaacc agattccagc cggccctgcc cccgctgata tggtccagcg acatcaattg 2663641 tctggagata gtgaatggct cagtaaaaga tgtagagaac gtccctacta aaccaatatt 2663701 tttggtaacc gatgccagcg cagataaaat ggtgatcggt tcaaaacggt ttaaaaaatg 2663761 aggaatcgat ttttcagaaa taaataagcc gtctgcaatg aaaataaaac taaacaaacc 2663821 tttttcagct gtttgcgcct ttttcatgta aaattcaata ttcgtgctgg ccgagggatc 2663881 aacatcggga tgacgccagc cgtcagttgt tcccccgaca ccgtgaatca tggctccaaa 2663941 ctgaataaaa tctgcacgtg tcatcttttt gcctccttta tctgtgcatg attagcaagt 2664001 gcaagatcaa ggtgttcaat gccgatttca gttatccctt gatactgatt gccgcgcccg 2664061 atttcgacca caggcacatg gcgcacccca tatttcacct gtaaaatatc ccgaagcttt 2664121 tctttctctg aaacatcgat attttggaac gggaaccctt tttcattcaa ataattcttg 2664181 acttcctcac aatacgaaca gcctttttta ctccaaacca caatgttcac aacatcactc 2664241 attcttctgt ccctccttaa cgttttgcag ctaaaactgc atcgctcagc agctgataag 2664301 acagctgttt ttctacagca tttttgatcg gtgtaaaaat aacaaaatca ttgattttgt 2664361 atgtgcctga taaacgtgtt aattcttctg ccacttcttc ctttgttccg gcaataatcc 2664421 cggttttttg cacgatgatg tcatagggct ctgtgacgtt ttccagatag gcctcagcct 2664481 gttcgcggga accgacgttg accttacgcc cgtctttcaa aaccactttt atcgattcac 2664541 gcgacacaat atgtttttcc gcttcttctt ttgtatgtgc cgcaaaaaca gcgggggcaa 2664601 gatgaaattc agcctcagat cctggcggga gatgcgcgtc aaatgctcgg cgggcttcct 2664661 tcagcacttc ctcttcaccg ttaataaagt aagcaaagac aaaagagatt cccagttttg 2664721 cagcagaaat ggcactctct gtgcttcctc ccaatagaaa aatacccggc ttccgatcaa 2664781 cctgcggcct aggacgcaat gcggcatagc ggtgggtatc aggaaaatca tcccgaacga 2664841 aatgagtaag ctcctccagt ttttcatcaa actgacgcac cggtttttta tattcggcct 2664901 gcagcgcgtc tgtggacagc tgaaacccgc cgggcgcttt gcccactcca agatctatac 2664961 ggccgggagc taacgctgat agaagatgga attgctccgc tactttataa gagctgtaat 2665021 gctgcagcat cactccgcct gatgctaaac gaatttttct tgtgcttgca gcaagatagc 2665081 ctaaaagaac ctcgggtgca gaccctgcaa tctcatcatt gttgtgatgt tcggccaccc 2665141 aaaatcggtg atatccacat tcttcagcca tttgtgccaa tttcactgta tgctgtaatg 2665201 tatcagctgc tgtctcccct tcaccaatca agctttggtc taaaatactt aagcggatca 2665261 tatcaccggc tcctttatgt gttcttttgg ttcaaataaa tattccggcg aaacacggcg 2665321 gagaaactgc ctcgttctgt cttttttggt atggcggaag acttcctccg gggttccttg 2665381 ttcaacaatg actccttcat ccataaaaac aacttgatca gagacccttc ttgcaaactc 2665441 catttcatgt gtaacaacaa tcatggtggc tccggttttc acgatttcca gcattacctc 2665501 aagcacttca ccgaccagct ccgggtcaag cgctgccgtc ggctcatcga acagcagcac 2665561 atcaggatga atggcaagcg cccttgctat ccctaccctc tgcttttgtc ctcccgataa 2665621 ctgactcgga taagcgttca atttatcttg aagcccgacc tttctcagtt cattttccgc 2665681 tacggcatac gcgtcttgtt ttctcatttt ccgggcaatc gtcaagccct ccatgacatt 2665741 ttcaatcacc gttttgtgag caaacaggtg gtattgctga aataccattg ccgtctgttt 2665801 tctgagccag tgaacctctt ttttggacgg aaagcggcaa ttaatcactt tgtcatgtat 2665861 agaaatgatc ccttcgtctg gacgttctaa taaattcagg caccgtaaaa aggtggtttt 2665921 ccctgatccg ctcggcccga taatcgtcac aacttctccc ttgcgtaccg tgagatttat 2665981 cccttttaat acatggtgga tgccaaactg tttatggata tttttaatct caatcataaa 2666041 gtgcctcctt gaaatctggc tgcctttctc tctaatactc catttgcgga ttctaggatt 2666101 agagtcagca cccaatagat aatcgctgct ccgataaacg cttctaaaaa tgcataatta 2666161 tcagaagcaa cgatagtcgc cgtccctgta atctctggga cagccactat agccgcgata 2666221 gaggtggtat gcaaaaagcc gatacccaaa tttgtgaagt ttgggatgga aaccttcagc 2666281 gcctgcggca atattacacg ccgaaaggtt tggctgtatg tcaagccgat tgaataagcc 2666341 gcttcgacct gtccggtatc catcgccaga atgcccgacc ggatgatttc tgtgagataa 2666401 gctccggcag ttaaagacaa ggccatgatg acaaacatgg agaccggtat ctcattagcg 2666461 gaccagccga gatgaaaaaa actgctgact tgatctgcaa caggcggtat ccctaaataa 2666521 atcaacataa tgtgaagaat tgcaggtgta cttcgaaaga aagacacata aaaccttgag 2666581 caagccacca agcccttaat tctaaaaatt ctaacaatta tatttccaag agccacgaga 2666641 aatccaaaca caatcggcaa aacagccatc atcaatgtca gaggaatggt ctttaccatt 2666701 tctttcatgg cggaaacgat aaatggaaag tcaaattgca atcttctccc ccctcatccg 2666761 aagaaatata tcaatgtatg ttcatgtcaa aaacagtaac aatccttgtt tgattcttct 2666821 tgattcgttt ttctgccact cgaaagaacc attcgaataa aaccgctaca gcataataaa 2666881 caatcgatag cgcaatgtaa acttcaagag aatggttgct tgaggtaatc agtgtttggc 2666941 cccttccgga catatccata acacctattg aaaaggctag agacgtatct tttaaagaac 2667001 tgatcaccat gtttcccata ttcggaaacg cctggacaag tgcctggggc agaacgattc 2667061 gcctgaaggc ctgactaccg cttaagccaa tactgtacgc cgcttccgtt tggcctttat 2667121 ctacactgcc cacccccgct cgaatgattt ctgcggctgc cgctgcattg cttaacgcgt 2667181 aggttgcgac agcagcataa aacgggtcca tttttgatgt atcaatcccg ataagccccg 2667241 taagcgccgg gatcccgtaa aacacgatga aaagctgcac catgataggc gttcccctga 2667301 aaaacgagat atacactttt gccaattgat ttacaattgg aatattatag atgcggggca 2667361 gtgccagaaa gagtcctaat acaaaaccga aaagcaagga cagtgttaaa atgtataatg 2667421 taaccggtaa ataagcggtt aacgtcggca caaaatctcc aatcatgttc atatcaaacg 2667481 ctttttccat cactgctccc tctcttttta cctaatactg ctctttggaa tagtcgtcac 2667541 caagccattt caaactgagc cttttcaacg ttccgtcatc aatgatttcc tgtaaggctt 2667601 tatcaatatc gtcacttaac gtttgttcat ttttgttaaa cataaaatac actttggcat 2667661 ttgaaagcac attaccgacg gttttttctt taatagtgct cgtcttgttt tgaaagtcta 2667721 ctgcaaaagg cgttgagatc gttgcgtccg cacgccccga tttcagctga ttcgcagtct 2667781 catttgcgcc ttggccctca taggcaatct caaacggccg tccattatcc tcattccatt 2667841 ttttcagtac aagcgctccg ttggaggttg cactcgtaat cacccgtttt ccttttaagt 2667901 cttcaattcc acggatcgta tcgttatttt gaagcacagt aatttttaaa ggaaaatggt 2667961 tgtaagcaac cttgttaaac agaaattttt tctcacgctc tttgcttttc tccatttgat 2668021 gtgccacgat atcgacttta tgctgtccga ggctgacaag caggttggaa aattccatcg 2668081 ttttaaatgt gaatttataa tgtggcaggc gcttatcaag ctctttgatc agttcgacat 2668141 cataaccggt taaatcgcct ttttcatcga taaagcaaat attcggaaat tgggttccag 2668201 ttccgaccgt gatcgtctgt accttctttt gcccggctcc cgtcgtttga ctgcctgcac 2668261 cgcaagctga cagaactgtt ataagcgaaa ataatattgc catgaatgct gttttcgttt 2668321 tcatctcatc gccccattta tttttcaaaa cttgattttg aataatctgc cccgagccat 2668381 tttcggctta gtttttttag cgttccgttt ttctccagct ttttaatcgc ttgatccgtg 2668441 tcatccgcca aggtttggct gcctttatta aacataaagt acacctcggt atctaataac 2668501 acgtcaccga ctgtcttttg gcggaaggcg tgcgttttat tctgaaaatc gacggcaaac 2668561 ggtgtagcta tcgttgcatc tgcgcgcccg gtttcaattt gattggcggt atcattgctt 2668621 ccctgtcccg catatttcaa atgaattggg ctgccgtgcg ttttgttgta ctttgtaata 2668681 taatctgccg catttgacgt ggcgccaact atgactgttt ttccgtgtaa gtcttttaat 2668741 gtatgaatct tgtgattatc ctctttcacc gtgatgtaca tcggcgagta gttatatggg 2668801 actttatgat acaaaaaacg cttttctcgt tctttatttt tggccatatt gtgcgcaatc 2668861 acatcaattt ttttatttcc gagactcgtc agcaaatttg agaaatccat cgttttaaat 2668921 tcaaatgtat attgaggcaa ctccttatcg atggctttca tcacttcaat gtcatacccg 2668981 gtcaattcac ctttttcatt taaaaacgca atattcggaa aatctgttcc agtgccgact 2669041 atgaccgttt gagcctgacg atctgttttg ttatttgttt gcgaacatcc cccgccaagt 2669101 aatgcaaaca ctgacagcag caaaaccaat cctttacgct tattcatagg ctgcctcaca 2669161 tcatgcccag ctgggcgcac ctaaaagcgt tgggttaaat cgttccggaa tcagaacctt 2669221 gtgcatcatc acacctatgt ccccgtcttt ttcctgctca aaatacactt cataccctct 2669281 ccttctgtac atgtcagcaa gccaaggatg cttgcgcgcc gatgtgccga gtgtcagcgc 2669341 aggagccttc agcatatctc gaagcacttt ttcttcaaca tacgtaagca gcttacttcc 2669401 ggcgccttgc cctttatatt ccggcagtgt cgcaaaccac cacacaaatg gatattttga 2669461 aggaggcgtc tcactctccc acgggaacct gattgtaatc gttgaaatca gcttcccatc 2669521 ccgctccagc acaatcgctg aatgatgttc aatattttct gataccattt ggatatcagc 2669581 tctcgtggat ggccaatcaa tatccagctg ccgaatgggc tgaaatgcgc tgttaaccag 2669641 tttcaacagc tccgatgcat cttcaacagt tgccagtcga aaaatatcat cactcatttt 2669701 tgtcactcct cttcacaaaa tatataattc ctatttgttt actaagcttt tattgtttat 2669761 actataaagc atactctgat ctttgactaa tcaaaaaaag taaaccttca cttcagtaat 2669821 tttaatgatg aaaaacagga gggagcacat tggagttacg ctcaatcaaa acgtttcata 2669881 cgattgtaaa atttggaagc ttctataaag ctgcagaaat actcaactac tcgcagccga 2669941 cgatatcgat gcgtatgaag caattggagc aggatttagg cgtactgctg tttgaaagag 2670001 gaaaaagcct gcagttgaca aaagcaggga agctttttta tgaacgaaca ggagatcttt 2670061 tgatgcaata cgaggcgctt aaacacaacc tctccgactt aaaggaagaa gaggcaggca 2670121 ttatcaacat aggggtttca gagccaaccg ccagtctgat attccccgag attttaaagg 2670181 atttcttaat ggattaccca aagataacgg ttaatatcaa ggttgatgac gccaatacct 2670241 gcagtcaaaa gctcttagac gggacgattg attttgcagt ctgcggcgag ccggagctga 2670301 ttcttgaaaa ttactaccat ccattttttt atgacacatt aaatgtgatt gtatctgatc 2670361 aacatccgct cgctgagaag aaggctgtcc atttgtctga tttagcagaa gagcgcttca 2670421 tatttacgcc cgccaattgc cccattcgct tacaaattga acagcattta catagagaac 2670481 tcgggaatcg ctacaaaaaa atggagctca caagcagcat gtcacatgaa tattacgtac 2670541 gtgaaaacat cggaatttca atctttacca gcaccgcaca ttctaaaccg ttcaacggca 2670601 ctaaagtcat tccaattctg aacctggata tcaccccgcc catagggctg ttgacaaatc 2670661 aaaaagaagt tcattttgac cgcgccacga aggacttgat cgcccggata accaaacgtt 2670721 ttcagcagcg cagcaaagaa ttggaaggaa cctctgataa gaccattaca ggataactga 2670781 aaaaataaaa accacctcct gattcatcag gagatggttt cacggtttaa agctcgatcg 2670841 tctcaccgac cgacatgact ttgccgactc cgcccggcag gctgtcagcg aatgcttctg 2670901 ggtcttgttc gatgaccggg aatgtattgt aatgcaccgg cacgacctgt tttgcgcgca 2670961 gccattcagc agcaagcttg gcgtcttcag gccccattgt aaagttatcg ccaatcggaa 2671021 ggaaagcaag gtcgatatga ttcaattcgc caatgagttt catatcagag aaaagtgccg 2671081 tatcgcccgc gtggaaaatc gttttatctt ctacagtcag caaaataccg gcaggcatgc 2671141 ctgtgtaagt gatcgttttg ttttcttcat ctgtgatggc tgatccatga aaggcctgtg 2671201 tgagcttcac ttttccaaaa tcgaactggc gggagccgcc aatatgcatt ggatgaacat 2671261 tcaagccttt ccagcctaag tacacagcga gctcgttcgg ggctataacc agcgcgttat 2671321 tttgcttggc gatttgttca gtatcaccga catggtcatt gtggccgtgc gttagtaaga 2671381 tgacatccgc ttttacatcc tccggcttta tatccgttaa tgaattccct gttaaaaacg 2671441 gatcaaaaat aatatgatgg tccttcgttt ccactgtgat tacagaatgt ccgtgatatg 2671501 tcactttcat ttctttcacc tcgtcacatg attttgtttt ttttattttc cctttttaaa 2671561 aagctgaaaa acttatgttg tttgattctt gttaatgaca ttgaggcctc cggtggcttc 2671621 aatgacagtc cctgtcacaa ggtctgagtt ctcctcacac aagaaagcga taatcctggc 2671681 aatatcctcg cctgtaccgg atcttcctat cggcgttttt tctttgccga ttcgcattct 2671741 ggcttcctct atcgatgctt ctttcatgtc gccgacaatg tctcctgggc aaaccatgtt 2671801 ggcggttatg ccgaattcgg cttcttcaat ggcaattgtc ttcgtcaaag aagccaagcc 2671861 cactttcgca gcgccaaatg ccgatcggtg aagccagccg ggcgcgtgag ccgcaccttg 2671921 gaatccgtac gtaataatgc gtccaaattg ctgttttctc ataataggaa taaccgcttt 2671981 gaataaatga aagacggcgc ttaaatttcc ttccagcatg ccataccatt catcatcagt 2672041 ataatcggct aactttttac gttcaaatat gtatggtcca gcgttgttaa tcaaaaagtc 2672101 gatccttccg aagcggttta aggcagcctc tgcaatacgc agcagatctt cttttttggt 2672161 gacatcacct tttacaaatt gcagccggtc aagacaatcg ggacaggctt ccttcaggcg 2672221 gctgactgcc tcctcatcct gtctgtaatt gactgttact gaatacccct ttgcaagcaa 2672281 cgtttcagtc actttgcggc ctaaaccctt cgaaccggca gtaattaaag catgtcgcac 2672341 atgaatacct cccaaagcaa cgtcgccgct ttcaataaag tgtttcttct tctactttac 2672401 tataaaaggc ttgcaatatc actttttaca ctttggcata caaaaaaagc tgcctgtaca 2672461 gacagcttat tctgcaggag atgaagactc ctgatcaggc atatcgacat aaccgctttg 2672521 atatgcttct gaaatgagcc ttgttgtctc ctggctttct tgttcatcat aaatatagcg 2672581 ttccggttct tttttcatca ttctgcctcc catcattata gaggtaggtt ggctataatg 2672641 acgggatttt atgaaggaaa ttttaacaaa ctcctgctgc cacgcaagct ttcgcttttt 2672701 caagcgcctg ttccacctgt ttgaatccgg tgcccccggc gctcattctt ttttcaactg 2672761 cgtagtaagg gtctaacaca gtgtaaatat cttcttcaaa tagtgtgctc gcctgctgaa 2672821 actcgccaaa cggcatatcg cttaaataga tccctctttc gatgcatgtg tacacaagtt 2672881 tcccgaccac ttcatgcgct tctctgaacg gcattccttt tttagctaaa taatcggcca 2672941 gttccgtcgc gtttgaaaag tcttgttttg ttgcttgctt catgacgtct ttgtttacag 2673001 tcattgtttg gatcatgcct gtgaagattt gcaggctgcc ctccaccgtt ttcaccgtgt 2673061 caaacatgcc ctctttgtct tcctgcagat ctttgttgta agcgagcgga agtcctttca 2673121 tgatcgtaaa cagccccatc atatcgccgt atacgcgtcc tgttttgccg cggatcagct 2673181 ccgccatatc agggtttttc ttttgcggca tcatgctgct tcctgttgcg tacgtatcgt 2673241 caagctcgat gaatttaaac tcctgcgagc accataaaat gatttcttca gagaaacggg 2673301 ataggtgcat catcagcata ctgctgttgc ttaaaaactc caaaatgaag tctctgtcgc 2673361 tgacgccgtc caagctgttt tcataaatgg catcaaagcc gagcagttcc gctgaataat 2673421 cacggtcaat tgggaaggtt gttcccgcga gcgccccgca gccgagcgga gatttgttaa 2673481 tccgcttcat tgaatcctga aaacgctcct tgtcgcgctc aagcatccag aaatacgcaa 2673541 gcagatggtg agcgaatgaa atcggctggg cgcgctgcaa atgtgtgtag cccggcagaa 2673601 tcgtttcaac gttcgcttcc gccttttcaa tcagcgcact ttggaatgcc tcaatcagct 2673661 cgatgatgtg gccgacatga ttcttcaagt ataaatgcat gtcagtcgcc acctggtcat 2673721 tccggcttct gccggtatgc agcttgccgc caagaggacc gatttcgtca atgagcattt 2673781 tctcaatgtt caaatgaata tcctcataat cgactgagaa ttccaatgct ccctcctctg 2673841 ctttttgcaa aagggtattc aggccctctc ggattttcaa ctcttcttct gctgtcagaa 2673901 taccgcattt tttcagcatg gcagcatgtg cgagagaccc tgtaatgtct tcagcaacta 2673961 aattttggtc aaatgatatg gacgcgccga actcgtcgac ccatttttcc ggtgtttttt 2674021 gaaatcggcc tccccaaagc ttcttcatgc tttaatctgc tccttctttt tcacgatgct 2674081 gttcactttt gtcggaagtc cccaaagctc gataaatccg attgctgcat ggtgatcaaa 2674141 tgcatcgtct tttgtatatg ttgcaagttt ttcatcatat agagagtatt ccgatttacg 2674201 tccttctaca attgcatggc ctttaaacag cttcacgcgg acaatgcctg tgacatgctt 2674261 ttgcgtttct tttaagaaag cgtgcagcgc gtcttttaac ggtgagaacc ataagccgtt 2674321 gtaaatgatt tctgacattt tttgctcgat gatcggttta aagtgggcta cctctttcac 2674381 cagtgtcaaa tcttctaatt ctttatgcgc tttgatcagt gtcatcgcac cagggcattc 2674441 gtatacttcc cgggatttaa tgccgacgag gcggttttcc acgtggtcga tacgtccgac 2674501 accgtgcgcg cccgccattt cattcagctt caagatcagc tcagaaagcg agtaggaaac 2674561 accgtcaatg gagacaggca cgccctgttc aaatgcaatt tcaatcactt ccggcgtgtc 2674621 cggcgttttt tccagcggag ctgttaaatc gtatgcacct tctggcggcg ccgcccatgg 2674681 atcttctaaa atgccgcact cattggcgcg tccccagagg ttttggtcga tagaatacgg 2674741 gctgtcaaga ttgatcggaa tcggaatgcc gcggctagcc gcatattcaa tttcttcttc 2674801 acgtgaccac tgccattcgc gaaccggcgc gatgacttct aggtcagggt ttaatgattt 2674861 aatggagact tcgaaacgaa cctggtcatt tcctttccct gtgcatccgt gggcaatcgc 2674921 ctgtgcatct tctttttccg caatttcaac cagttttttc gcgatcagcg gtcgagataa 2674981 tgccgaaaca agcgggtatt ttccttcata cattgtgtgg gcctgcaaag agataagcgc 2675041 gtaatcctgt gcaaattctt cttttgcatc gatcacgtag gagtttgtcg cgccgacttc 2675101 aagcgctttc tgctgaacaa atgccaaatc tttgccctca ccgacatcca ggcagcaggc 2675161 gattacatta tatccttgct cctgaagcca ttttattgcg acggaagtat caagacctcc 2675221 tgagtatgct aatacgactt ttttctgttc tgacatgata aaaatcccct ctcaaccgtg 2675281 tttctatttt gtataaaaat aaattatatt taataaaaat acattttgta tgtatacact 2675341 ttaacaagta cgtttcgttt tttcaagcct tttataaaaa aaacttcacc taaatttcag 2675401 gtgaagtttc atagtattta ttcatttact tgtcttttct gatttctctg accacatgcg 2675461 caagttcggg aataatcagc ttattcattg ccagctttac tgcgccgctt gagcctggcg 2675521 ttgagaaaac agcggtatgc tgaatgacgc cggcagttgc tctcgacatg attgcggcag 2675581 agccgatatc ctctgtataa ctcagcatcc tgaatatttc tccaaagccg ggcagttctt 2675641 tcgaaaacag cggcgttatg gcttcaattg tgacatcccg atctgctatg cctgtccctc 2675701 cgtttaagag taccgcgtct gtctgttcat ccatgcagcc cgcaagcact gaccgttgca 2675761 aagcatcctt ttcgtctttt acaatttcat atgcggcaat atgatgaccg gcttcttcta 2675821 aaaatgagat catcagcttg ccgcttttat cggtttcatc tgtcctcgtg tcactgacag 2675881 taatcacttt gcaccgaacg atatcgggag cttcttgttt atgctcttga acgctcattg 2675941 gcccacctct tttatgtttt ctgtctgtca ctatcatgca tcaacaaaaa agcacattca 2676001 agagaatgtg ctttcatgcg atttattttg ctaaacgaac aacgtcgcgc gcaatcatga 2676061 cttcttcatc agtcgggatg atcatgactt ttactggaga atgcggatag ctgatgaaag 2676121 cttcctcgcc gcgcacgtta ttaagcgcag ggtcccagta tacgcccatg aattctaaac 2676181 cgcgaagaac gcgttctctg acttccacac tgttttcacc gataccggca gtaaagatga 2676241 tcgcatctac accgctcatt cttgcagcgt aagaaccgat gtatttgtgg attctgcttg 2676301 cgaatacttc aagagccgtt tccgcgcgct catttccttc tttcgtagct tcaacgatgt 2676361 cacgaagatc gcttgagaaa ccggaaatgc cgagcagtcc gctttttttg tttaatgtat 2676421 tcagtacttc gtcagccgtt tggcctgttt tctccatgat gtatgggatc agggcagggt 2676481 cgatgtttcc agagcgtgtg cccattgcta caccggcaag cggcgtaaag cccatggatg 2676541 tgtcaataga ttttccgcct tcaacagcgg caatacttgc tccgtttcca aggtggcagg 2676601 aaatcaggcg caagtctttt aacggacggc cgagaagctc tgccgcacgc tcagttacat 2676661 atttatgtga agtgccgtgg aagccgtatt tacggatgcc gaatttttca tagtattcat 2676721 acggcaagct gtaaaggtaa gactgctcag gcattgtttg gtggaatgct gtatcaaata 2676781 cagctaccgc aggaacattt ggaagcactt ctttgaacgc tttaattcca acgatatttg 2676841 ccggattgtg aagcggtgcc aattcagaaa tatcttcgat ttccttaatg gtttcatccg 2676901 ttaataaaac agaatcgctg aatttttctc cgccgtgaac gacacgatgg ccaattccgt 2676961 caatttcatt caagtcttta ataatgccga attccgttaa cttattcagc agcattttaa 2677021 cagctaccgc atgatctgga atatcagtta cttctgtatt tttttcgccg ttcacagaaa 2677081 ttgtgaatac gctgtcggcg ataccgattc gttcaactaa acccttcgtt aaaacggttt 2677141 ctgaaggcat ttcgaaaagc tgaaatttca aagacgagct tcctgcgtta attgcaataa 2677201 ttttggacat gattgacgct cctttatact ctgtatcaac aacttcgttt ttcgtacttt 2677261 tttcccggtg aatatcaaca tcttctccga aaaatatctg acttttccat ttaaacattg 2677321 tcatgtcggc ttttcaagtc aacttgcgta ttgataacgc ttacaataag aagtcgttat 2677381 tttcagacac attcactata ggttttgtat tgatgaacgc ttacaatttg cggtttttcc 2677441 ctctgtattt tgtgtttcaa agctggattc aattcgtcaa gtccggtctt caaaagcata 2677501 aataaaagca gcttaggcat cgacctcata cggctgtcta agctgctttt aaaacactta 2677561 cttttctttt ttaaaccatt catcaaattg agccatcata tcaagcatcg ccttttgatt 2677621 ggagaaagac ggaagattcg caagcagaat ttgccccggc gctttcgtat tctctccttg 2677681 tttctgaagc acaaggatgc ttttggcatg agcttcgtct ttaaaaatag attttggcag 2677741 ctgcaacagt gcgttgatat gaaccttatc tttgaaaaac tgtttcagct tgccgctttg 2677801 ggagctctca aacaaatgat tcggaatcat aaaaaataag tagccgcccg gtttggtatg 2677861 cttgacgctc tgttcaataa acagatgatg agcgaaggaa tggccttcgt cagctttgag 2677921 ctcaaacgct tctgctcctt cgtcattcgg ataatagccg actggcagat cacaaatgac 2677981 cgtgtcaact ggatcgataa acaacggctc aaggctgtcc tggtggaaaa gctcaagctc 2678041 ttttttcaga aggttcgctt gggcataggc gatcttcaag agcacatcat caatttcaat 2678101 gccaaagctg tttgccgttt tttcagacag ctggttcagc acggtaaaca gaaggttccc 2678161 agttcccagg gctggatcaa gaatggtcag ttcctttttg tccgccataa atttattcac 2678221 caaatagctg atgaaaagcc cgatcgtatc cggcgtcatt tgtctgtttg gatgcgagat 2678281 atctttcatt cctttaagga cggcaagctg aaaagccttg cgtacccact catgctcata 2678341 cgtgccgaat tccgcttttt caagcagagc ctgaagttgt ttggttttct gatcagcagg 2678401 cagtttcagc tgatccgttt tttcaagaaa atacatttct cctgcttcgg ccagcgcctc 2678461 tatatatgaa atctgcaatt cattctttat cataatcgcg gcttcgttta acagctcata 2678521 caccgcacct acatggtctt tttgcatatt gtgttcctcc ttgccatgaa aaaagctccg 2678581 gcggcagcct ggagcttttt tccctgctta ctttactaat gccttagcag cctcaattgg 2678641 cttttcatag ttcgggtggt ttgttgcttc gcttacatat tcagcgtaaa cgacttttcc 2678701 gttctcatca aggacaaata cggaacgcgc aagcagacga agttctttaa tatacacacc 2678761 gaacgcttcg ccaaatgaca tatctctgtg gtcagacagt gtttccactt tgtcaattcc 2678821 gttagcgccg caccagcgcg cttgcgcgaa tggaaggtct gcactgattg tgtagacgtt 2678881 gacatctcca agctttgcag cttcttcgtt aaaacggcgt gtttgtgcat cacaaacacc 2678941 tgtatcaatt gaagggataa cagaaataat cgttaccttt cctttcatgt cagctaacga 2679001 tttttcttca aggctgttag tcagcactgt gaaatcagga gcttgatctc ctaccttcac 2679061 ttcttgtccg acaagtgtaa ccggaccgcc tttgaatgta atttcagcca ttataattcc 2679121 tcccttttgt atgtatgtct ctatcatagt aaagtttcct gcaaactgca aagtttatgc 2679181 caaaaaaaag ttaactgcgg ccagcgcagt taaccttttt ttaataattc atattgttca 2679241 tttggttttg attttggcct tggctttggt ttttgttatt tttcttgaac atttgctgga 2679301 tgcgctcgag tgtttgaggg gctgcgtcta aaattttctc tattaaatgg gtattttcat 2679361 ctaaatgaag cattctgatg cctgtcgatc cgacaattaa aaacgcgatc ggcgtaatgg 2679421 acacaccgcc cccgcttccg cctccgaaag gaagtttctg ttctcttgtc tcatcgtctt 2679481 ccgatttctt ttcggccggc tttccgccaa actcgcttcc gcctgcggcg aatccgaatc 2679541 caactttaga aacagttaaa atcacacttc catcaggcgt ttccactgga tctccgatga 2679601 tggtgttaac atcaatcatt tccttcaagt tttccattgc ggttttcatt aaaccttgga 2679661 tgggatggtc tgccatatac gcttcctcct taaactgatg aatcattctt tgaagtcatt 2679721 ctagccgacg gattcttctt taatacggat agctcccgtc cgtatttgac gaatttgaaa 2679781 gctgcaagca tagcatgtcc aaagcgaaaa aagaatatac actgaaaatg ggtcttggaa 2679841 acagggactt gaaacgacgg gatcacctca tagacaggtt tattcacaaa gtccaggtgg 2679901 tcgtagagca ttgctgcgat accgcccttc acgccccata cagcaccggt taacacacct 2679961 gtcactgccg cgtcctgaat tccgattact gtaacccatt ctagttttgt gatatgtaaa 2680021 tgcgcgagaa aagacgcgct gattttccgc agtctggtga cctgatgcaa aagcatttcg 2680081 attttattaa tgctttgctg cacatcgttt tgtgtaattt ttttctttcc gctgcttttt 2680141 ttcattttgg attcagtttt ttgtttgata tccactgttc cgtcttcttt gttcacctta 2680201 atcgccggga ttgttttttt gatccttata aggccaaaca gcgccgtaat cttcaaggtc 2680261 aatttgtcat tatcatcggc atgaagatac tccagcgcga catggatttt cattctgaga 2680321 agcagtacga tccctatgag aataagaatg gctgtcagta catacaccat attcttcact 2680381 tcctctagga gcattatcgc caattcctaa aaaaataaac ccggacggaa gtccgggtta 2680441 tcggttattt gcggtataat ttttcatgca ccacggtggt atccgcgatg taatcatgaa 2680501 tcccttgttt tgtaggtgaa aaggcaacaa cgatatataa aatccaaatc ttatcaatat 2680561 accgtccaac cacttcacga aaaatcactg tactccatgt cagcttgcta tcttgcttca 2680621 cagaaaccac tttgaggccg aacaccattt taccaagcgt ctgcctgaag tattttgtca 2680681 tgagtgcgaa ataggcaaga tacacaataa gcgttgtcac actgtaggcc gagaaggtaa 2680741 acatgccgga tgttttcggc agatccaata cggtaaagag gggagaaacg agcaaatggt 2680801 ttaatcccca tatcacgagc caatcaagca ggaaagccca gaaacgaacc caaaagccag 2680861 cataggcatg tgtcagcagc tccgcttctt gcgggccttt gatgtcattg cgctctaact 2680921 cttcatatgt cgcgtccatt attgttccct cctacttcgc atagagatac atcattctcg 2680981 gcgaaccgga ttgcgataga atttctctca tattcaaaaa atcaatttca cttttaaaca 2681041 ttttgttcgc gcccatggaa aacagtgagc ctaatccgaa gctttcctca taagaaatga 2681101 cagaggcgtt tttcaaatcc ttgtgatcct ttttcatggc cgtaatggta tcgtcataaa 2681161 aaccaagctc atcaacgagg ttcagttttt tcgcctgccg tccgtcatac acgcggccgt 2681221 ccgcaatttt ctttacctct gctttcggca tgccgcgccc ttttgaaatg acatcaacaa 2681281 agccttcata cgaattatca accatcgatt gcatgatgtt tttttcttct ttcgtcatct 2681341 cacgggaagg agacataatg tccttatggg ccccgctctt aatcgtttca aaagaaatgc 2681401 caagcttgtc ggcaagcttt gaataattga cgctttccat aatgacgccg agtgacccgg 2681461 tcagggtttc cggtgtcgca aaaatcttat cagccgctgt tgagatgtaa tagcctcctg 2681521 atgctgccat cgaacccatt gacacgtaaa tcggtttttt cgtttctttc ttgatttctt 2681581 ccagtttctt atgtatttca gcactttcat acactccgcc acccggagaa ttcaccttca 2681641 gaacgatacc tttgaccgtc ttgtcatctt ttgcgcgctc aaggtttttt aagaacgttc 2681701 tgtggttata tccgtctgca ccaagcagac tgcttgagtc cccattatcc tgaatggtgc 2681761 cgctgacctc taatacggca attttacttg agggactgcc gttttccagc gtcttctcct 2681821 gcgattcatc cgtcagtgat gtgagatccg tttgagcgcc tttgacgctt tcaaagaaac 2681881 tcatagagat gctgacgata atagacacgc cgaaaatccc cagagcaatc actaatgcaa 2681941 tccatctttt tgcattcatt ttttctcctc ctttttccta aactctctca ttatacgatt 2682001 caatatgaaa aatgtttcac ttcatgagaa agctccggct taacgggctg ccggcaaacg 2682061 tggtacactt atggccaaag gtattttatc acaaatactg gatggcagaa aaacttaaat 2682121 atgacagcaa aggggaaatg ggatatgacc gatcaacgcc gtaatgttta tttttttcac 2682181 aaacaggatc aggaaacgaa cgaacaagcc cgctcgttaa cacaattagc ggaagagcat 2682241 ggatttaccg ttgtgaacca gcactcagac gccaatatta tcgctagcat tggcggggac 2682301 ggcacatttt tgcaggcagt cagaaagacg aattttcgtg acgactgctt gtacgtcggc 2682361 attaccaaaa aggggaaagc tcatttatat tgcgactttc atagtgatga gcgagaaaaa 2682421 atggtcgatg caatgacgtt tgaacaaatt gaagtgagaa aatacccgct gattgaagtg 2682481 acagtggatc aagccagtcc ttttcactgc ttaaacgagg tatccatccg ctcaagcatc 2682541 atcaaaacct ttgtgatgga cgtgctgatt gacgatctgc actttgaaac gtttagaggt 2682601 gacggaatga ttatctcaac gcctacaggg agcaccgcct ataacaagtc tgttgcagga 2682661 gctgttgttg atccattgct tccatgcatg caggtatcag agcttgcatc ccttaacaat 2682721 aatacctacc ggacactcgg ctcgccattt gtcctcagct ctgaccgaaa gctgaccctt 2682781 cgtgtggtgc aggacggcaa cgaacaccca atcatcggct tggacaatga agcactcagc 2682841 acgagaaatg tgaaaacgat cgaaatcaaa ctgtctaata agaaaatcaa aacagtcaaa 2682901 ctaaaggaca attcattttg ggaaaaagtg aagcgtactt ttttatagaa aataaaagga 2682961 caggctgctg cctgtccttt tatgatttct catatacaat ctggccgtta atcacggttt 2683021 ttttaatctc taaaagatga agctgtgcgg ggtcaatggc aaacggatca ccactgagaa 2683081 ctgtaaaatc cgcgtcatag ccttccgcaa tttttccgcg tgacttctct ttataaatga 2683141 taccggcgct accttctgta taaagcttta tcgcttcata tacaggtaaa cattcacttt 2683201 cattatagct tggcccgttt tgctcatgac tgcttttccg gaggaccgcg gactggatcc 2683261 ctagaagcgg gtcaacaggc tcaatcgggg cgtctgaacc gcccgcgcat aaaatgcctt 2683321 tagatatgag ggttttccag gcaaatgcag tcttcatccg gtcttttccg agacggtcaa 2683381 tgacccacgg aaagtcgctt gcaacgaagt gcggctgaag gtcaagtgcg atcggcatgc 2683441 gtgctgctct ctcgattaat tcgttatcaa gcacttgagc atgaataagc cgatcatgcc 2683501 ggccgttttt gggcggatgc ttttctattg cgttcagcac tttttcaaaa gcaagatcgc 2683561 cgattgcatg aacagcaacc tccatccctt tttctctcgc tttgcgaatg agccggccaa 2683621 gggtttcgtc atcgtgaacc tgaacaccat ttgttgatgg atcatcctga tatggttctt 2683681 tcaataaagc cgttctcccg ccaagcgccc cgtccgcaaa gattttcata gcaccgaact 2683741 ccacatacgg gccggacagc ttctccagct gctcccatcg atcgacagct tcatgatgaa 2683801 cgagcaaatg gcagcgaaac ggatactttc cgccagcggc agctttctca taagctttca 2683861 tcggcaccga aacatcacca taataggaca agtcttccga atgaccgccc gtcaggcctt 2683921 ttgtccagca atcctttatt gcagccgtta atgcctcatc aacatagtgc tgggagactg 2683981 gcgggacagc cttcagaatc aaatcctgcg ccttatcaaa caggagtccg gtcggctcgc 2684041 catttgcatc ttttacgatg actccgccgt caggatcagg agtatttctt gaaattcccg 2684101 ctgcttgaag agccgcagaa ttgacagcta ttgcatgccg gcatatacgc ttgagcaaga 2684161 cgggcctgtc aggaaacagg cgatcaagat catgcttagt caagtagtca ggtgtctcaa 2684221 actgattttc attccagcct tctccaatga gccaatcgtt tttaggaagc tgccgctctc 2684281 tttccttcgc agcctgtaaa attgaatctt tcgacgtcag tgcggacaga tcgagctgaa 2684341 gctgtttctc accgtggccg atcaaatgta gatggctgtc aacaaaaccg gggaacatca 2684401 ctgctccgtt caggctgatt tcttctgttt ccggcgaccc gtacttttcc ttcaaacgtt 2684461 catagctgcc ggtgcctttt ataacaccat cctcaacata aactgcctca gtccgatcgc 2684521 cttcttcgag catcgtataa atgaaaccgc cgtgccatat cgccttcatt cacgttcact 2684581 ctctttcttt acgccttttt attggctttg agctgttctt cacgttttct taattccact 2684641 cgtctgattt ttgcagaagc cgttttcggc aggctttcca caaattcaat ttctctagga 2684701 tatttgtatg gagcggtaat cgtcttcaca tggttttgca gcattttgac aagctcatca 2684761 ctgcgttttt catgattttg caggacaaca tatgccttta cgatggagcc tctgatttca 2684821 tcagggcttg cgacaacagc acattctttt acttctgggt gcttaacaag cgcgtcttcc 2684881 acctcgaaag gcccgatcgt atagccggag ctgataataa tatcgtcatt tcggctttca 2684941 aaccagaagt aaccttcctc atcttttctt gctctgtctc ccgttaggaa ataatcgccg 2685001 cgaatttgtg ttttcattct ttccggatct ttaaaatact ctttaaagag cgcaggcgta 2685061 ctgaggtgaa cagcgatatc gccaacctca ccaggtttgc agatttcacc gtcttcattt 2685121 atgatctcca cctgatttcc cggtgtcggt tttcccatgc ttcccggttt aataggcgta 2685181 tctttcaaaa caccaaccaa aagcgtgctt tctgtttggc catatccgtc ccgtacctta 2685241 atgccaaagt gcttttggaa aacatcaatg acttcacggt tgagcggctc acctgcggaa 2685301 acagcgctgt gcagggcaga aagatcaaag cgtttcaagc cttcaacctt cgccattaag 2685361 cggtattctg tcggagtgca gcagaaaaca ttgattttgt agcgatttaa aagctctaga 2685421 tatttttctg ctttgaatct gccgtggtac acaaaaccgg ttgctccgct gccaagcacc 2685481 gctaaaaacg gactccatac ccacttttgc cagccagggg cagcagttgc ccagacgata 2685541 tccttttcag aaatgtcaag ccaagcgccg gcagaagttt ttaaatgagc aaatgcccat 2685601 ccatgtgtat gtacaacacc tttcggctga cctgttgtcc cggatgtata agataagaaa 2685661 gccatatcat ctcttgttgt gtcagctgtt ttaaattggc ttccgtccgc ttcaattgat 2685721 aagaggtttt tccagccggc atcattttca ccaatagaca gtgtaatcag tttgtcagcc 2685781 gtactgacat cccggaaagc gccaataaat tcggagtaga cgatagcgcc ttttacctct 2685841 gcatgttcaa tccggtattc aagatctttc gcgcgaagca tttcggagca cggaatgaca 2685901 accattcctg atttcaggat agccaaataa acagcatagg cttcaagcac ccgcggaacc 2685961 attacaatca gcttgtctcc ctttttaaat ccaagatcag ctaaggccgc tccgatttta 2686021 tttgtttctt ccatcagctt ttcatacgac caagattctt gcttgcccga ctcgtcctcc 2686081 caaagaagag cggttttttg tccagcagca ctgaactttt ccatttcatt cactaaatta 2686141 tattgcacag gggcaattaa atcttcacgt tttaacacga acaactcctc actttctcca 2686201 cccattatac ataaatacag gctctttccg taaggatatg cctaaaagca acctctgtaa 2686261 acatagattt tataggccgc tggtcctttt ttatatgtaa aaaatgaaaa agagtgggga 2686321 tacccccact cctaagccat tatgtgaaat tgtaaattag aattgtcctc cgcccatgtt 2686381 ttgttgagca aaagatacaa gacgttttgt gatctctcct ccaacagaac cgttagcgcg 2686441 agaagttgtg tctgctccaa ggtttacacc gaattcagaa gcgatttcta atttcatttg 2686501 gtcgatcgct tgagcagctc ctggtactaa aaggttgttg ctgttacctg agttattgtt 2686561 agccatgtgt ctcacctcct tgtgagtata gaatgtgtca aaacacatgg cttcattcag 2686621 aaaaactttg gtaattgtat acaggagctg aaaattgatt taaaagagtt cagcgaattt 2686681 atcgttagct tcttgttcgc tataaagggt cattgtctca atgttatcta ccgcttcttg 2686741 aatatacggc tcgaaatcaa caaagctttc aaagtgttca attttctctt ttttagggcg 2686801 tgttttcggg cttggcggtg taaagatcgt gcagcagtct tcaaacggct gaatacttgt 2686861 ctcatatgtg ccaatttccc gtgatttttc gatgatttct gttttgtcca tggcgattag 2686921 cggacgcaaa atcggtgttg acgtcaccgc attaattgca tacatgcttt caagcgtttg 2686981 gctcgctacc tgaccgaggc tttctcccgt aataatggca agcccgtttc tcttttctct 2687041 gattctgtcg gctatctgaa gcatgaggcg gcgggttgcc gtcattgtgt aattttcagg 2687101 aatttgtttt tggatgagct cttgcgtttt tgtaaatgga acaatatgaa gtgtcatgct 2687161 tcccccaaaa cgggacagac atttcgccag atccattacc ttttgctttg cgcgctcgct 2687221 tgtgtatggc gggctgaaga aatgaacagc ttctaccgac aatccccgtt tcatcgcata 2687281 aaaaccggcc acagggctgt caaaaccgcc agaaagcatc agcatcgctt ttcctgctga 2687341 accaactggc agcccgcctg cacctttttc atcacgaatt gtcaaaaatg ttgcttcttc 2687401 cctgatttcg attctgagcg ggatgtctgg gttgcgaaca tcgaccgtca atccttctgt 2687461 atttcgcaaa atatggccgc cgatttcagc gttcatctgg tttgtatcta attcaaattg 2687521 cttatacgct ctctttgtcg cgactttaaa cgtatcacct ggtttatact gatctttgat 2687581 agcctttagt gcggttgcct taatatcatc aaggcggctg tcacacttaa ttgccaggct 2687641 gaagctttga atcccaaaca cttgctttaa atgaggaaaa agagcctcag gatcctctcc 2687701 atttaatgta atcgtcatac gatccctgtt ggaaaagtat tttaaattcg gatagtcttt 2687761 caaaacgagt ctgatgtttt gttttaagcg ctcaataaag ctttttctgt ttttgccttt 2687821 ggtcgaaatt tccccaaaac gaattaatat atgatcgtaa ttcatgttct acctcatcat 2687881 ttcccttaat tttttgatgc caggacgaag cgcgttcata aacggttctg ccacatcgct 2687941 tgtctggctg taatttaaac tgattctgat gctgcttccg gcaatctgct ctcctttgcc 2688001 catctctaag agaaccttgc tgggcttatg ttcttttgcc gagcaagccg atgttgtgga 2688061 gacgaatata tcctgttcct caagcatgtg taaaagcact tccgctttaa tccccggtac 2688121 agagaaatta ataatgtgcg gcgcgctatt catttgaggc gtgttgataa cgacgccctc 2688181 aatttcactc agcctattca taaacaattc ctttacggca gtcatcgtgt caagccgtgt 2688241 gtcaaaatca gcagaggcca gattaatggc cttggcaagc gaaaccgcac cagcagtatg 2688301 ttctgttccg gcccgtatgc ctttttgctg agagcctccc gttatgagcg gaataaggcg 2688361 tgttccttct tttacaataa gtgcgcctgt cccctttagg ccgtgaaatt tatgccccga 2688421 aattgaacat agatcaatgc cggccttttc aattgccaag ggcactttat agatgccctg 2688481 cacataatcg acgtgaaaca aaatgttcga atgctctttc agcacttctc ctgccgcttc 2688541 aatcggctgc acggaaccga cttcattgtt cacatgcatc atgctgacaa gcacggtatc 2688601 gggacggatg gctgctttta gatcttcaat agaaacaaat ccgtcttcat tcacagaaag 2688661 ataagtgata tcaaacccga acaactcttt cagctgttct aacgattccg taacggatgg 2688721 atgttcaata gaagtggcaa tgatatgttt gcctgttttt atctttgaca aagccgctcc 2688781 ttttaaagcc gcattattgg cttctgtggc gcctgacgta aatacaatat catatttttt 2688841 taggcctaag gaccttttga tttgattttt ggctgcttga agcagctgtt ccgtttcggc 2688901 tccatatcgg tgcaaagatg aaggattgcc aaagtatcgg ctgctcgtct gttcatatac 2688961 gttcaagact tcatcgtaag gcttcgtcgt tgaactatta tctaaatata tcatcttttt 2689021 tactccttta tgaaagcggt acaaggtatg atatttatgt taccataaca aaatttaata 2689081 gaaaattacg aaaaactagt attgacttct aattttttta ccatataata agatttgttc 2689141 gtttcgtcat attatctgac aattaattga cagaatattt taacataatt attaggagga 2689201 tttttttcat gaaacactca ctgcctgtca aagataccat tattattggt ttcatgctat 2689261 ttgcgttatt ctttggagca ggaaatatga tttatccgcc ggaacttgga caagcagccg 2689321 gacacaacgt ctggaaggcc atcggcggat ttttactgac aggggtaggc ctgccgcttc 2689381 tcggcattat cgccatcgca ttaaccggta aggacgctaa aggccttgct gacaaagcgc 2689441 accctgtttt cggcacaatc tttactgtcg tgctttattt atcaatcgga ccattattcg 2689501 ccatcccgag aacaggaact gtttcatatg aaattggcgc tgttccgttt ttgactggtg 2689561 taccagaaag actttcttta ttaatattta cacttatctt tttcggcgtt acgtactatt 2689621 tagcgttaaa cccatctaag gttgtggatc gagtcggaaa aattctgact cccatcaaat 2689681 tcacaattat tttaatcatt gttctcaaag ccatcttcac gccgatgggc ggattgggcg 2689741 ccgtgacaga agcatataaa ggaacaccgg tttttaaagg atttttagaa ggctataaaa 2689801 caatggacgc acttgcttca attgtatttg gcgttgtcgt tgtaaatgct gtaaaaagca 2689861 aaggcgttac acagtctaaa gctcttgctg cagcctgcat taaagcaggt gtgattgccg 2689921 ctttaggcct gactttcatt tatgtatccc ttgcttattt aggtgcaaca agcacaaatg 2689981 ccattggtcc tgttggtgaa ggagctaaaa ttttatctgc gtcttcccat tatttattcg 2690041 gttcattggg caacatcgta ctcggagcag cgattacagt cgcatgttta acaacaagca 2690101 tcggccttgt cacatcttgc ggccaatatt tttcaaaact tattccggca ttatcatata 2690161 aaattgtcgt tacgattgtc acgttattca gcttgatcat tgcgaatttc ggactcgcgc 2690221 aaattatcgc gttttctgtt cctattttat cagctatcta tccgcttgcc attgtcatta 2690281 tcgttctttc cttcatcgat aagatcttta aagaaagacg cgaagtgtac atcgcatgct 2690341 tgatcggtac aggacttttc agtattttag acggtatcaa agcagccggt ttttcacttg 2690401 gatctttaga tgtgtttcta aatgcgaatc ttcctcttta cagcctcggc atcggctggg 2690461 tgcttccagg aatcgtcgga gcggttatcg gctatgtgct gaccttattc atcggaccat 2690521 ccaaacagct taatgaaata agttaatgtc acagaacgcc tgcgttattg cgcaggcgtt 2690581 ttgtaataaa aaaagagcct gctcattaca ctgcgggctc tttttcatgg tcgtgattat 2690641 ctaagcggat atgtcagctt tgattttttc aactgcacct ggcgcagcct tttctacagc 2690701 ggcagcggca atttcataag agtcgtcata atcaaaagca taaaaacgtc tttccgcttc 2690761 tttcagctgt tcagataaaa tatgattctg gcttctgaac cggtttccga actgaatgat 2690821 tttttcaatg aggatgacct gctcgacaag ttcctctgat tcccggcttg ccctgttgac 2690881 gatatcttct gcttgtttca aatgggctcc ggcttcttcc atatttaatg gaagttcgtt 2690941 tagttgattg accgtttctt gaatatgatg atgcgcgttc tccagcatct cttgaatatg 2691001 gctcggaatg cctggaatgt tgctagtctt cagcagtctt gctgtctcag aaattgtttt 2691061 tttcaaattg ctgagcgtct ccctcgcctg aagctcttct tttctcagcg cttgcagatt 2691121 ttcacgatac tcggcatgct cttttttcac ttcttcaatt tgcttctcta ttgaagcaac 2691181 ttcttctact aaaagtgagt aggcgacatg ctctgcatca agcttatctt taacggatga 2691241 tagcagcttt ccaatttcat caaggcgctt ttcaaaagcc tgctgtttgc cgagctcacc 2691301 ggctgtcagc ctgtagcttt ccttcaccag ctcagtttcc gctttcgtat gctctttctc 2691361 ttctttaagc ttgtcgtaag caataatcaa ttcaggcatt ttgcttagta cggattgacc 2691421 ggcttcaact tcgccctcca gctgctgata aacagattga atattttcgt caatgagctg 2691481 caggattgcg gacgcttcat caatatccag ttcagtcatc aggacatgtt ccgctcgttt 2691541 cagctggttt gacagatttt ctaattcctt atcaagctgg atatgctcaa gcttgtaccc 2691601 tttttctttc atttcgccat agccatcctt gagctttgca atctgtccgg gcaccgtctg 2691661 tttacagtca gctaacagct tcggcacatc atctatgtat gactgaagcc gttcaagatt 2691721 gcggtcctgc tcaagcagta cttttcgtgc agtaatatag tttccgcctt ctgtttcttc 2691781 ttcaaattgt ttgatgccgc tccaaatttc gtccagatcc ttttcaaggc tgtcataaag 2691841 ctccccgtaa aggtggctgt aagccagcag gttttttcga gatttcgaat agcgctccct 2691901 cacctgttca atctcttcac ggctcttttc ctcacttgtg acaagatcgc tgatttcccg 2691961 aagaatcttt tcaatgcttg attcagccgc tgtcagcagg tcgtcgatat gaacgagcac 2692021 ttgattggcc tttttaaacc ggtatttgtc tgcattttcc tcggcatcat aaaggagctc 2692081 ttcaactttc ggcatgtggg ctgtgacaat ctcatcccat tcttcacgcc acttctcaaa 2692141 gaactcttct gtctgacccg tcatttttaa atgttttatt ttagacattt cttccacgat 2692201 cgaccgattc agaatttcaa tcttccacga ttccagccgg tcgatttcgg cgtagatttt 2692261 tttcctgaaa aagtagcctg ccgcaaacag cgcaagcagt acaattaata atccaatgac 2692321 aaactccata atgagccccc ttgctgttta ccttaatctg tcagggtgtt ttatttattc 2692381 agaaagattt caggatatgt attgagaaaa actgtcgttt tcattgttat tatgatacca 2692441 tgtaacaaac attttttgac cagaaatcaa aaactttttg tgcaaaatcg gcaggatttg 2692501 actatttttt catggggtga catcaatgca aaagcgagac ggacatattc acacaccatt 2692561 ttgccctcac ggctccaatg acacactcag acaatatgca gaagaagcct taaaaaaagg 2692621 gttcgaatcg attactttta ccgaacacgc cccattgccg ccatctttta ccgatcccac 2692681 gccgctgaaa gacagcgcga tggcgcaagc ttctttggaa cgctatattc atgaaatttc 2692741 cggattaaaa aaagaatatc gcggacagct tagcatacgg acagggcttg aagtcgatta 2692801 tatcgctgaa tttgaagacg aaattacatt attcctagac acatacgggc catatttaga 2692861 tgacagcatc ttatccgttc attttttgcg cacagactct tcctatctat gccttgatta 2692921 tgacgagcat accttcaaag agctgatttc agcctgcgga agcattgaag cggtatatga 2692981 acaatattac cggagtatct attcttccat tgtagcatct ctcggcgttt ataagccaaa 2693041 aagagtcggt cacatcacac tcgtccaaaa attcatcaag ctgtttccat acagcatgtc 2693101 agagcatatt cgcggcctcg tttctctgtg cctgaatgcc attgaagaaa acggaatgga 2693161 gctcgacttc aatacttccg gcttaagaaa aacttacgct ggcggtattt atatcgagga 2693221 ttggatgctg aatgaagcga agcaaaagaa gatcccgctt gtgtttgggt ctgatgccca 2693281 tcaagcggga gatgtcggat atgcgtatga ggcgtttttg gaacggtgct agttggtgag 2693341 cgccacgtct cctgtccgga agacgcttct gatccaaatc ttgatttctt caaaatacat 2693401 tttataaaaa tacggctcgt gcggctgcat gtagagtact tctgaaatat attgaggctg 2693461 gagatagggc atcatcaaga gagattttaa ttggagaata aaatgaggca gcggcagcgt 2693521 taaatattca cgctgttttt ctccttcctc aatgatcagc tggaagatat acttttcctt 2693581 cattagatat gtcgacataa tttccctgat taatgtggag tcaattgtga cttcccggta 2693641 gacaaaacga gttaattgac gatgattatg ctgataggat aaaatatcga aaaccaattg 2693701 aagaagctgt tcctgcgtgc tttgagtaga gatattgctt gccgctgttt caagcgtttt 2693761 gctgtagcct tcgtaaaact ctgaaactaa gtgttccatc aagcctcctt tgcctttaaa 2693821 atagtaggag atgtgcgcaa catttacatc agctgacttt gcgatttcac ggacagacgt 2693881 gccagaaaat cctttttggt taaaaagcat gacagcagat tcaataattt tgtctttggt 2693941 gcttactttc atacggctca ctccttcctc ttgatactat tcaagcagaa agccgctgtt 2694001 cctgtaagaa cttatcgaca aatgccggca gaaaagccgg aactttgttt tatattatag 2694061 aaaaagtgag ggttttccat gttccatgtc gaaaaacaat ctggagataa agaaaaagac 2694121 tatcagcttc tgctaaaaca gctcgaagcc atgaccgaag acgaaacaga ccaaatagct 2694181 aactatgcaa atgcctcagc actgctgtat cattcgctgc ctgaagtcaa ctgggcgggt 2694241 ttctattttg ccaaagaaga ggatggacag cttgtgttag gtccgttcca aggcctgccg 2694301 gcatgtgttc ggattccttt cggcagaggg gtttgcggca cagcgtacgc aaacggaaaa 2694361 gtggaacgta ttgaggatgt aaacgcgttt ccgggacata tcgcctgcga tgcagcgtct 2694421 caatcagaaa ttgtgcttcc gattcgtgta gacggaaaaa ttgtcggcgt cttggacatc 2694481 gacagcccag tgaaaaaccg tttcgacgaa attgatgaaa aatacttaac tcaatttgcc 2694541 gaaacgctag aaaaagcgtt agcgcagtaa tataaaagcc caaaactgat atcgttttgg 2694601 gcttttttta ttttattgag tcatgaatca tcaagcggtt tttcccgctc cgtttcgcgc 2694661 tgtagagcgc ttcatctgcc tcatgcacaa gctctttcag cgactttttt gtttctgtcg 2694721 tccagcagga gataccgcag gaaatggtta cctcgggttt cgtatttttt ctgaccgcgt 2694781 aaaccagtcg ctcggtaatc cgtttcccca ctgcaaccgg cacatttggc aaataaatcg 2694841 ccagctcctc tcctccccag cgggcaccga catcatgctt tcggatgttg cttttaatca 2694901 ctgaagcgac ttgaattaaa atctcgtccc cagtctgatg gccgtacgta tcatttacat 2694961 ttttaaaatt atcaatatca acaagaataa aaacaccctt ttgatggatt ttcatgctgt 2695021 attgaatttt ttcatctaaa tacgctcgtg aatacagttc agtcagctga tctgttttca 2695081 cgagatgctc aaggcggtcg cgaagcattg aattggttac agccagtgtc gcgtgatgaa 2695141 tcagcgcctg aaacagcttg tacatttcaa atgtaaaagc gtacagctcc tgtttcaata 2695201 aaaccgcaaa gcctaaaagc cggtcgtttt gaatcatcgg agcagccatc agcgagccgt 2695261 accccgcctt cccaaaaaca gactggccat tcccgatgaa aacccctttt tcaccttcat 2695321 acagcttttc tttcagctca ttataaaaat ctgacggctt cgcttcttta aaaaatgctg 2695381 tgctgcctgg gagcaatgtt aggttttcaa aatggtctat atgaaaaaat cccacttctt 2695441 ctgcctgaaa cgattctgcc attctcacag ccagatcatt cattgtatca gtcaatgtca 2695501 gccgctgatt caggcgtcgt gatgtttcat taatcaattc caaatttgcg atgcttgctt 2695561 tggattgttc gtagagctgg gcattttcaa acgcttttcc cgcggcgttt gctaacagcg 2695621 acatttcatc aaggcaggca tcagtaagaa agctgtcacc cgttccttca gccttcaaca 2695681 ccccgtatgt gccctgctgt cctttgatcg gaatataggc gacagattca tttttccgca 2695741 aaatgtctcc ggacaaatac actttgagcg caaaggaatc ggatttttcc ccttccatat 2695801 acagctcttt tgcaggaatc cctaaacatt ggtcttgatc gtgcgatata aataaagaaa 2695861 actcaaaaag agaaaatgtg cttgtcaagc tttctaaaag ctgcttcagc acatctgtct 2695921 gatcaagcag tgaatggaac agctctgtca ttttgtatat ctttttttgg tagatcgttt 2695981 tgttatagag tctttcctgt ttcatcgact ggtttaaaaa tgaagcaacc acgtccggaa 2696041 gcccttcagg aatctcttca tcctgcctgc acgcaagatg gaaacgcctg ccggagccgt 2696101 cctcaatcag ataacatgaa gcgtttattt ttgaagcgga aaaacgcgct tcaccatctg 2696161 ccagttttgt cacaaagtct gatggtgacg gtgtaagcga aacacaaagg gttgaaaaat 2696221 aggtttgaat agccgaagtc agccatatga aagagtcggt gaatgtgact ttttcagatt 2696281 tggttaataa aaaatcgagc atatgataat gaaaggcgga taattgatct ttagtttgtt 2696341 ctaccatgtt tttatcacct aaaagtttac cactaatttt tgtttattat atcataaacg 2696401 gtgaagcaat aatggaggaa tggttgactt caaaacaaat aaattatata atgacctttg 2696461 tgtgaaatat tgcagccttt ttgttcagct tctatgtttt cattttgttc cttatcaata 2696521 aggtgtatcg tgtaactctc tgctgctgga gcgaggatac atgaaaacaa aatgtgcatg 2696581 gtcgaataga gcagacggtt tttattttcc acaaaaataa aaccaaagga ggagtcacat 2696641 tatggctcgc tatacaggtc catcttggaa actgtcccgc cgtctaggaa tctctcttag 2696701 cggtacagga aaagaattag aaaaacgccc ttacgctcca ggtccacacg gcccaggaca 2696761 acgtaaaaaa ttatcagaat acggtttgca attgcaagaa aagcaaaagc ttcgtcacat 2696821 gtacggtgta aacgaacgtc aattccgcac tttgtttgac aaagctggca aactagctgg 2696881 taaacacggt gaaaacttca tgattctttt agattctcgt cttgataacg ttgtgtacaa 2696941 gctaggttta gcacgtactc gccgtcaagc tcgccaattg gttaaccacg gtcacattct 2697001 tgtagacgga agccgcgttg acatcccgtc ttacctagtg aaacctggtc aaacaatcgg 2697061 tgttcgcgaa aaatcaagaa acctttctat catcaaagaa tctgttgaag tgaacaactt 2697121 cgttcctgaa taccttactt tcgacgctga aaagcttgaa ggtactttca ctcgtcttcc 2697181 tgagcgttct gaacttgctc cggaaattaa cgaagcgctt atcgttgagt tctactctcg 2697241 ttaatcgttt taaaaacccc tgccgctatg cggtcggggt ttttttatcg gctttcgcct 2697301 cttgctggcc aacactatct tgcgcctgct gctcccaatg atcccgctgc agccgttctt 2697361 ttgcaatcgt acacatgaga ttcacgcttt agcgctcctt tcatttaaaa ggtggtgatt 2697421 ggtcgtgttt gccctatcta atatactctt ttcctttcat tcctatgcgg taaacaaaaa 2697481 gatcctttgc cttcagtggc aaaggatctt tttcttattt atacgtcaca aggaagtatt 2697541 ttttcttccc gcggcgcaga acagtaaatt ggttttcgat gcggtcttca cctgataggg 2697601 tataatttat ttccgtctgg cgttcaccgt taatgtaaac agctccgttt tggatgtctt 2697661 cacgcgcttg gcgtttagaa ggagataatt tagattgcac caacacatct acaagtgaaa 2697721 gctcttgggt gctgtcaact tccatagaag gaacatcttt aaagcctact tttacgtctt 2697781 gagcagaaag ctctttaata ttgccgctga acagcgcttg ggagatgttg atggcttgct 2697841 ccagcgcctc gcgtccgtga acaagtgatg tcacttcttc tgccaggcgt ttttgcgctt 2697901 cacgtttttc tggcgccgtt tctgtttttt cagcgtatgc ttcaatttcc tcttttgaaa 2697961 ggaacgtgaa gtatttcaag tatttgacaa cgtcacggtc gtctgtgttg atccagaatt 2698021 gatagaattc atatggcgat gttttttctt tatcaagcca gatcgcgccg ccttccgttt 2698081 ttccgaactt cgtgccgtct gcttttgtga caagcggaat cgttaggcca aacgcttttg 2698141 ctccttcttc ttctgatttt ctgatcagtt caagacccgc tgtgatgttg ccccactgat 2698201 cgcttccgcc gatttgcagt ttacagtttt tgtctctgta aagatttaag aaatcataag 2698261 attgaagaat catgtagctg aattccgtgt acgagatgcc ggattcaatt cttgagctga 2698321 ccgtatcttt tgccagcatg taattgatgc cgaaattttt accaacgtca cgaaggaaat 2698381 cgatcacatt cattttgccg atccagtcaa agttgttcgc gatgacagct gggttttctg 2698441 ctgcttcaaa atctagaaat ctggacagct ggtttttgat tttttgggac cattcggata 2698501 cgatgtcagc agtgtttaat gtacgctctg ctttttttcc gcttggatca ccgatgaggc 2698561 ccgtcgcgcc gcccacaagc gcaatcggat gatgccctgc aagctgaaaa cggcgaagtg 2698621 ttaaaatagg cagcaggtgt ccgatatgca agctgtctgc tgtagggtca aagcctgagt 2698681 acaagcggat tttttcttca ttcagctgtt tatttaaccc ttcttcatct gtcatttgct 2698741 gaatcaatcc gcggaaggat aagtcttcaa gtaagttagt cataagataa agctcctttt 2698801 ttaattaaaa taaaaaacgc cccttcgttt acacgaaggg acgattgatt atcgcggtac 2698861 caccctacta ataagagaat gcaaacattc gtcttatcac tttgcctgat aacggatcag 2698921 gtccgttctt tcactactga aagcctggcc ggctttgttt gcaaaagcgg ttcatgagtg 2698981 tattcgatat atccgtctgt gctgattttc accggccatc agctctctgg aacgtaagga 2699041 tattctactt gtctcaatct ttaccttttc atatgaagct atatcatttt taacataaat 2699101 aaaatcctgt gtcaacgccg ccttttaatc ctccattgtt gacagatctc cagccggcag 2699161 attaagctcc catgccttca gcacgcgcct catgatcttt ccgcttctgg ttttcggaag 2699221 cttatcttta aattcgatct cacgcggagc cgcatgggct gcaagaccct gctttacaaa 2699281 taggcggatc tcttctttca gtttatcaga cggctcaaat ccttccctga gtgcaataaa 2699341 ggctttaatg atttctccac gcaccgggtc aggctttccg ataacgcctg cttctgcaat 2699401 agccggatgt tcgacaagct tgctttccac ttcaaatggg ccgacgcgct caccggaggt 2699461 catgatgacg tcatcaactc tgccttggaa ccaaaagtat ccctcttcat ccatgtaagc 2699521 agaatcccca gacacatacc agccgcccgg catgaaatac gattcatact tttcagggtt 2699581 attccaaatg gtatgcatca tggaaggcca gccctttttg atggcgagat tgcccattcg 2699641 gtacggcggt agctcgttgc cttgattgtc aacgatcgct gcctccactc ctggaatcgg 2699701 cttacccatt gaacccggtt taatatccat gcaaggatag ttgcagatga gctgactgcc 2699761 cgtttcggtc atccaccagg tatcatggat tcgtttgtta aaaactttat gtccccatct 2699821 gatgacttcc ggatttagcg gctcaccgac actgagcaca tgccggagtg aagttagatc 2699881 atatttcgca gccatttcat ctcccgctcc catcagcatc cgaaaagctg tcggcgcgct 2699941 gtaccagaca ttgacgccaa gctgttcaat cgttccatac cagctttccg ggctgaaacg 2700001 tccgccgacg atgacatttg tcgctccgtt cagccacggt gcaaaaatgc cgtataccgt 2700061 acctgtcacc cagcctggat cagccgtgca ccaataaatg tcttcttcct ttaaatcaag 2700121 gacccacttt cctgtttgat attgctgaat catcgcttca tggacatgca acacgccctt 2700181 tggcgtacca gtggaacctg atgtatagtg aagcagaaag ccgtcttttt tatccatcca 2700241 ttcgatatcc aatcttgtgc tttcctgttt cgctgcttca tcataattga tgatattcgt 2700301 gccgctctca gcctctcccc cgactacgaa gacatgctgc aagtgaggca gtttgtctac 2700361 cggtattctc tccagcagct caggcgttgt gacaacaacc tttgcctcac tgttttcaag 2700421 ccggtctttc accgctccct ccataaatgc ttcgaacagc ggcccggcga tggcgccaat 2700481 tttgattgcg ccaagcataa taaaataaag ctcgggtgat ctcggcataa aaataaaaac 2700541 gcggtcccct ttttccacat ttccataccg tctcagcaca ttcccggctc tgtttgattc 2700601 ttccttcatt tctttaaatg tgtatttttc atcccttttt gcgtctttat aataaagcgc 2700661 tactttgttt tttcgaaacg attcggcatg gcggtcaatc gcttcatacg ccgcattcag 2700721 tttccctgtc tcatgccaag agaaatgttt ctctgcctcg gcccaatcaa aatgccggta 2700781 cgtttcttca tagtttttta agttatgatc cccctctatt gctggtaacg ctttcaagtt 2700841 catgcccaaa catccccctt tgctgaagtt gtcacaatta ttatagtata tattcatatt 2700901 cttctcaatt tttaaaatat aaaccatgtt gaaaacgctt tataatttgg tattcttaaa 2700961 gaaggcatgt atttttgata agaattgatg ggacggtgaa ttagtggaac atcataaaac 2701021 ataccattca gcaaacatca aaacagcaac cggctcttta ctgatagaag ggcctgtctc 2701081 tccagaggat ttggcaggtt atgagtttca taaagattta accgcatttc gcccgcctcg 2701141 cgagcagcat gaagcgctag tcgacattgc aggccttccc gaagggcgca ttattattgc 2701201 cagagacggc cgaaccattg tcggctatgt cacgtattta tatcctgacc cgctcgaaag 2701261 atggtctgaa ggaaatatgg aggatttgat tgagctcgga gccatcgaag tagcgccgga 2701321 ctatcgggga tgcgctgtcg gaaagacgct cctgaccgtc agcatgatgg atgaacaaat 2701381 ggaaaactac attgtgatga cgacagaata ttactggcat tgggatttaa aagggatgaa 2701441 aaaagatgtg tgggaataca gaaagatcat ggaaaagatg atgaatgcag gcggattggt 2701501 ctggtttgca acggatgagc cggagatcag ctcccaccct gcaaactgtc tgatggcccg 2701561 cattggaaaa aacgtcagcc aagaatcaat tgagcaattt gacaggctcc gtttttatca 2701621 tcgttatatg tattaactga cactgacaaa ggggaaaaaa taatgattgt tgagcaaatc 2701681 atgaaaagag atgtcattac attaacgaag acggatacgc ttgaaacagc aatatgcaaa 2701741 ctgaaggaat tccatatcag gcatctgcct gttgtagatg aagaacgaca cgtgatcggc 2701801 atgattacag acagggacat gaaacaggcc agcccgagta tttttgaaga aaacaaacga 2701861 agcctatttc tcacacgaag cgtagattca attatgaaaa aggatgttgt ctgcgcccac 2701921 ccgttagatt ttgtcgaaga aatatcagcc gtgttctacg agcatggcat cggctgccta 2701981 ccagtggtac accatcaaaa attaataggc attttaacaa aaaccgattt gctgcggacg 2702041 tttgtcaaat tgacaggcgc tgaccagccg ggctcgcaaa ttgagataaa agtaaacgac 2702101 atcaccaaaa gcctcgctga gatcagcagt ctttgccaag accttcaagt gaaaatatta 2702161 agcgtgcttg tttatccgca tgacgatccc ggtgtaaaag tgcttgtctt ccgtgtaaaa 2702221 acgatgaatc cgctgccgtt tttgcaggca ttacaaagaa atggacacca cgtcgtatgg 2702281 ccgtcagagc aaagggatct gctatgagag acagtgtatt tatctattct ccatcctacc 2702341 aaacctatat gtttcatcag gagcatccct ttaatcagca gcgggttctg ttaacatatg 2702401 atttgcttaa gacgatcaat gcctttgatg atggagacat tgtcaccccc agactcgctt 2702461 cagaagagga gctttccctt gtccacacgg acgattacat tcaggccgta aagcttgcgg 2702521 gcgccggaaa gctccccgct gaagaaggag aaagctacgg gctcggcact gaagacacac 2702581 ccgtctttgc cggcatgcac gaagcggcat cactcttggt cggcggcact ttaacggccg 2702641 cagactgggt catgtcagga caagccctgc atgcggcaaa ccttggcgga gggcttcatc 2702701 acggctttcg cgggagagca tcaggattct gcatatacaa cgacagcgct gtggctattc 2702761 aatatatcca gaaaaaatat agcgccagag tgctttatat tgatacggac gcccaccacg 2702821 gggacggtgt gcaatttaca ttttacgata atcctgacgt atgcacgctg tccattcatg 2702881 aaacaggaag gtatttattc cctggaaccg gtcagatcca agaaaaagga agcggaaaag 2702941 gatatggcta ttcctttaat attccgcttg acgcttttac agaggatgat tcttttcttg 2703001 aggcttaccg gacagcagct tcagaagtcg ccgcgtattt cgagcccgat gtcattatca 2703061 gccaaaacgg cgccgatgcc cattactacg acccgctgac gcatttatca gcaacaatca 2703121 atatatacga agaaatcccc cgtcttgcac acactttggc tcatcaatat tgcggaggga 2703181 aatggattgc agtcggaggc ggcggatatg atatttggcg tgtcgtgccc cgcgcctggg 2703241 ccagaatatg gcttgaaatg aagggaattg acccgggtca cgagatcccg ccggaatgga 2703301 ttgttaaatg gcaaaaacaa tgccccgtgg cccttccgtc gagctggagc gatccggctg 2703361 atttatatcc tccgattccc cgcaagcctg aaattacaga aaaaaatgcc caaactgtca 2703421 gcaaagcatt atatgcgata cgttctgaac agcaaagaac aaagtaaaaa acgaccttta 2703481 cgaagaggtc gtttttgatt ttttaatcac tatttccaca cgccgatttt ccttcatgtg 2703541 ttcatttgtc ttgttatcct ttactggctt tgtatccgca taaccgacag caataaagcg 2703601 cttggaggga agcttctctt tagacgtgaa gtattgaatc actccacttg cccgtgctgc 2703661 tgatagctcc cagttcgacg ggtatcggta tgtcgaaatg tttcggctgt ctgtatgtcc 2703721 ctcaacctga atgtcatttg gaattgtttg aagaagaacg gcaatttggt gaagaagtgt 2703781 ttcggcattt ttcagcacct ttgcctcacc tgtatcaaac agcacagcct cctgaagaac 2703841 gagcacgaca ccgcgttcat cccgtttggc tgtcatttgg gccttcaaat gattgtcttt 2703901 tatatatgta tttactttct tgagaagctg atcctgctga tcctcttgct tcttcgtatc 2703961 agatggggat gtattctttt tttctatgga tgtttggtcc ggctgaagcc cgttgccttc 2704021 cttctggatc gagtccactg ccgctttgaa tttttgcaga tcgatttggg acatcgaaaa 2704081 gagtaaaata aagaacacaa ggatcaaggt gatcagatct gtaaaggtta ccatccagct 2704141 ggatgaagat tgactgtttt ttccgcttcc attccttctt tcaaaacgtt ctcttctaag 2704201 cttcatgtac agatcccttt tttgttttta cttgttttgg ctgcttctgc cattcttccc 2704261 gtgagctgaa aacgaccagc tggctttcaa ggttgcgcgg gttttttccg gattgaacac 2704321 cgataatccc ttccaccatt acctgcttga tgaaaatttc actttctgtt ttctcttcaa 2704381 gcttagccgc gatcgggttg aagaccatat ttgccagtaa tgaaccatat aaagtcgtca 2704441 gaagcgcaat ggccatgttt ggtccgagca tatgcgggtc gtttaagttt ttgagcatca 2704501 gcacaagccc gacgagtgtt ccgatcattc cccatgccgg agcgaattct cccgcttttt 2704561 caaaaactcg ccgccctttt cggtgccgtt cctccattgc tgcgatttct gaatccatga 2704621 cgagccgaat cgtttcttca tcccagccgt caatcgctaa aagcagccct tttttcaaga 2704681 atggatcttt gatttcccga gcctgatcat ccaatgataa aagcccgtgt tttcgcgcgt 2704741 gatcggaaag ggaaacaaag gttttcacaa gatctttcac attgtcttcc tggcggatga 2704801 atgcctgctt taacacagag ggcgcttttt tcagctcact tggcggaaaa ctgataaaaa 2704861 cagcggcgca aagtccccct gttacgatga agaaagaggt cagatcaaga aaagagcgga 2704921 aaccgcttac tcccgatcct gaaataatcc cgataacaat aataatcgtt cctaacacaa 2704981 atccaacagg tgtaagataa tcaaaacgtt tcatcatttc tccccatgaa aaaagcaaga 2705041 attcaccata aaggtgaagc ttgctctttg tttttcttat gacttggttg actttctaag 2705101 ctctatacgg tgcggcagtt cgacgatatg ctcttcaacc ggctctttat tcatgagctt 2705161 cgtcagcagt ctcatcgcaa cggcgccgat atcatatgtc ggctgaacaa ctgttgaaag 2705221 ctgaggacga accatgaggc ttaatcttgt attatcaaaa ccgataatgt cgagatcctc 2705281 cggaatggat aagccctgat cctgagcggc atggataatg ccgagtgcca tttcatcagt 2705341 tgcagaaaga atggctgtcg gttttttatc caggctcatc agatgctgca gtgcttcgag 2705401 tccggaatca tatgtgtaat ccccttcagc tacaaattgt tcattaaacg gaaggttcgc 2705461 ttcttcaagc gcacgtttgt agccttggag ttttttcgaa cggttgatcg gttctgccat 2705521 tggtccggaa acgaacgcga tgtctgtatg tcctttatca accaaaagct tcacggcatc 2705581 ataaatcgcc tgttcgtaat cgatagcgac tgacggtgtt tcctcctgct cttctacaga 2705641 agcggcaagt acaatcggca ctggagaacg cttaaattcc gccacatgct cgtccgtaat 2705701 gtttccgccc ataaacacga tgccgtccac ttgtttgccg agcattgtgt ttaacaagtg 2705761 cagctctttc tccatgtttt ggtcagagtt gctcaaaata atattgtatt tatacattgt 2705821 cgcgatatct tcaattccgc gcgcaagctc tgaatagaaa atgcttgaga tatcgggaat 2705881 gatgacacct acagttgttg tttttttact tgccagccct cttgccaccg cgtttggacg 2705941 gtaaccgaga cgttcaatgg cttccaagac ttttttcctc gttgtcggtt ttacattcgg 2706001 gttgccgttc acgacacggg aaacggttgc catgcttaca ttagcttctc tcgctacatc 2706061 gtagatcgta atattgctca tcctaaaacc actcctttta ctggatacac ttatccttat 2706121 ctatagcata aacactttat gtagagaaat gtcataatgt ccgaatttat gtcgtttatg 2706181 atttgtaagc gtaagtcagt agtgtacatt atttttcatt attcatcaaa tttaattact 2706241 tctcatgaaa ttatacacgt ttttatagat gatgaaaacg tatacttggt ttttataact 2706301 aaataaacga gaaagcataa aaaaaggccg caggcgcggc cttttggatt gttcaattaa 2706361 gcgttgactt tcaccattgg cttcagttca ttcagccatt tttcgaattc aggaatcgcc 2706421 atttgctgag cagagtcaga aagtgcgact gacggatcag ggtgaacctc agccattacg 2706481 ccatcagcac cgatcgctaa agcggcttta gctgtcggaa gcaagaggtc acggcggcct 2706541 gttgaatgcg taacatcaac aaagactggc aaatgcgttt cttgtttcaa aatcggcaca 2706601 gctgaaatat ccagcgtgtt tctcgttgct gtttcatatg ttctgattcc gcgctcacaa 2706661 aggataattt ggtcatttcc ttgtgacatg atgtattcag cagcattgat gaattcagag 2706721 atcgttgcag caagaccgcg cttcagaagc actggctttt tcacggcgcc ggccgctttc 2706781 agcaattcga agttttgcat gttgcgcgct ccgatttgaa tgacatcaat gtagtccagc 2706841 gcttcttcga tatgagccgg agttacgatt tcactgataa ccgccagatc aaattcatcc 2706901 gctacacgtt ttaaaatttg aaggccttca acaccaagcc cttggaaatc gtatgggctc 2706961 gtacgaggct taaaggctcc accgcgcaaa attttaatcc cttgtttttt cgcagctgca 2707021 gcgacttcag ctacctgctc atagctctct accgcacatg ggccgacaat gaatctttgc 2707081 tggccgtctc cgattttttc gcctttgata tcaacaattg tatcttcagg ttttttcttg 2707141 cgggagacaa gcagcgcttt gctgtgatct tcttcctgaa gctctaaacc ggctttgaat 2707201 atctctttaa aaatgtgctg gatggttgaa ttttcgaacg gcccgtcatt gttttcaatg 2707261 atattgttta acattgtgcg ttctctgaca gggtcaaatc ggttgacacc ctgtgcttcc 2707321 ttcgctttac cgatctcttt tacaacattg ccgcgttcgt tgattaattt taaaatttgt 2707381 aggtttaatt cgtctgcttt ctgccttaaa agctctaact ctgtgttgct catttttttc 2707441 atcctttccc tgcacattca ttttttattt tgtagttatc atgcatctta ctataagtaa 2707501 ttccaaatgg aaatactgaa atacaaaaaa ttttataaaa actctacttt attacccaaa 2707561 cgcttttaag tgataaagta atctatgaag ctatcctaca tgatgtgagg gcaatgttca 2707621 agggtttttt acaaaaaaaa gcgccagatg atatctggac gcttttttct atgacaaatg 2707681 ctgctcaata gcggcttctg taatttgtga atgtgaggta tgccatttca cttcaccgtt 2707741 ctggatgatg aatatctgag ggctttcatg cttgacccca tatgtttctg caatgaaatt 2707801 ggacagcggc cgggcttctt gtacttgaag atagtaagcc ggcacatcct catgctgatt 2707861 tgcaaaggca tcaaactcat gaaatgctgc ctggctgatc gggcatgtgg tgctgtgttt 2707921 caagaagacg aaaacgcctt cctgttctgc aatccgttta aattcttcct cagattgaat 2707981 aagctgttta gccatgactc aagctcttcc ttccctgctc agcgattcaa ctgctcagcc 2708041 tgtttttgtg catctttcag ttcgtctttt acatcttctt tcgtctggag gacttgatct 2708101 tttgtttcat cagctgcctg catcgcttct tccctcatat cttgcattgc agtcgatgaa 2708161 tccgttttgt cagatttgga acggtctctc aaatccttta ccttgttcat gatctgtcca 2708221 gactgatccg ctacaagctg tgtgatgttg gaagttttgt cttttgcgat gctgacatat 2708281 tgcgtgcctt tttccttcgc atctgccgtc attttatcag ttttgtcccg taaggcaaca 2708341 gcctggctgc cgagatcgtc gcgaagttct ttgcctgatt taggcgctag aaaaagagct 2708401 gtagtggcac cgatgattcc cccgattaaa gttccgatta aaaaatcttt actattaatt 2708461 ccatctttgc tcatcattat tcctcctctt agtatttttt tctcttacag ggctgatttt 2708521 ttcttttgct tccatttctc ccaaatttcc attgctgctt gactccaagt gacaacttga 2708581 ttgatcttat cttgattctc tctaactgat gccgatacag accctgccgc ttgtttcatg 2708641 gatgtattga actgctgtac agaagctccc actccttgaa cagcatgaac gaccgtgttc 2708701 agcttttctg atttttcctg aatatcttca gccaggcggt tggtcttatg taaaagctcg 2708761 gctgtttcag ttgtgatgcc cttcatttgt ccctccagcc cttcaagagt ggatgcgacg 2708821 ttttttagtg tcagctgcag tgacttcaat gttttagaca agtagatcac taatacgaga 2708881 aatgcaactg cgatgagtgc aacgctcaaa taaagaataa taatcatctc aaacctcctt 2708941 gctgcaggat atactgctgt ttacccgttt tcttcaatca taaacatgtg tactgggctg 2709001 tatacatact attctccgtt atgtaagaaa atcctttaat aagctttccc atcagataaa 2709061 taaaaagcag tgagatcact gctttttatt atgccatgac gttttcgtag gctctcatat 2709121 atttttggat atctcctgct cccatgaaga tgagaacggc tttatcatga gcttttaaaa 2709181 cagatgtgtc atcttcttca atcagcttgg cattatgaat ttttccctgg agatcaccga 2709241 tcgtcagctt tccggcattc tcacgggctg agccgaaaat atcgcataaa tacacacagt 2709301 cggcgccgct caggctttct gcaaattcgt caaggaactg ctgcgtccgg gtaaatgtat 2709361 gaggctggaa taccgcgaca atttcccgat caggatactt ctgtcttgcc gcctcgattg 2709421 tcacttttat ttctgtcgga tgatgggcat agtcatcaat cagcacttga tccccaagct 2709481 gcttctcatt gaatctgcgt ttgacgcccc caaaggattt gagagcatgc ttaatgatgc 2709541 tggaatcaat ttcttcataa tggcataacg caatgaccgc caatgagttt aatacattgt 2709601 ggtggccgta cgcaggaata taaaacgtat catagaacgt attgcggaca aagacatcaa 2709661 aagttgtccc ttccgtgctt tttacgatgt ttctggcttg aaaatcattt tcttcccccg 2709721 tgccataata cacaaccggg acgttcgcat ggattttcgg cagatgctca tcgtctccgc 2709781 aggcaataat gcctttgttg acttgaagag ccatctcttg gaaagcgtca aatacatcgt 2709841 caatgcttga gaagtaatca gggtgatcaa aatcaatatt cgtcataatc gcataatctg 2709901 gctgatagct taagaaatgg cggcggtatt cgcacgcttc aaacacaaag tattcgctgt 2709961 tttcatttcc ctggcctgtt ccgtctccga ttaagaaaga cgtcggtttt gcgttttgga 2710021 tcacgtgagc cagcagaccc gtagtcgacg ttttgccgtg tgcgcccgta acggcaacac 2710081 tcgtgaattt tttcatgtag tcgcctaaaa acttatgata acgtatcacc ggaattccct 2710141 cagacatcgc tttttctatt tcaggatgcg tgtctgggaa tgcgtttccg gcgatgactg 2710201 tcatgccggg tttaatattt tccgcgctaa aaggaagaat cgtaatattt cttttttcaa 2710261 gcgctgtttg cgtaaaaata aatttttcga tatccgatcc ttggacagta tatccattat 2710321 catgaagtat ttgggcaagc ggactcatac cggtcccttt tattccaaca aaatgataaa 2710381 cagtcataat tgtacctcca acaaacgtct atctgttccc cagtatatga cgctcatttc 2710441 aatttgcgac cgcggcggct gaaaagcctc ccttagcggc gtattttata tgttttgtta 2710501 tgtttagtat caggttattt ctttccgatt aaacccagat atcaagattt gtctatgcac 2710561 agctgctgta aagcggcata gctgttaaat gctctaaaca ctatcatacc atgtttggtg 2710621 tgaaaatgaa cccatattat tcgtttatta aatcacttgc tgtgatcagc acctctcgag 2710681 gcttgcttcc ttttgcctca gagatcatgc cttccgcttc catcatgtcg atcagccttg 2710741 ccgcacgatt gtaaccgatt ctgaatcttc tttgcaggct tgaagtgctc gcactgtttt 2710801 gctctacaac aaactcacac gcttcgtaaa acagttcgtc ctcttctttc agggcagatc 2710861 cttgtcttac gagctcttct tgttcaaata aataggtcgg cggcatttgg cttctgacgt 2710921 gggaaacgac gcggtcgatt tcccggtctg acacaaagtt accttgcaga cgaaccggtt 2710981 ttcccgagcc gttttccaaa aagagcatat ccccttttcc gagaagcttt tctgcaccgg 2711041 ctatatcaat aattgttcgg gaatcaacct ggcttgagac agaaaaggcg attctcgttg 2711101 ggatattcgc cttaatcaga cctgtaatga catcgactga cggacgctga gttgcgacga 2711161 gaagatggat accgcacgct ctggcttttt gggcgatccg cgcaatgctt tcttccacat 2711221 cgtttggagc caccatcatc aaatctgcaa gctcatcaat aatgacaact aaatacggca 2711281 gcttttcacc catttggtgt tcagcggtta attgattaaa gcggtcaatg tcgcggacac 2711341 ctgaatgggc aaaaagctca tagcggcgct ccatttcctc aacgacccat ttcaaagcag 2711401 ccgtagccgc tttagcatca gtaatgaccg ggctgacgag gtgaggaatt ttattgtaag 2711461 gggccagctc taccattttc ggatcaatca gcagcacctt tacctcactc gggtcagctt 2711521 tataaagcag gcttactaat attgtattga tgcatacgct ttttccggag cctgtagcgc 2711581 cggcaatcaa gccatgcggc attttcttca agtcgataac aacaggattt cccgaaatat 2711641 ctaatcccag cgcagctgtg agcggtgact tgcttgtcct gaaagctgag ctgcgaatca 2711701 tttggcgcaa atcaaccacc ttgctcgtgc ggttcggcac ttcaattccg atcgtgtttt 2711761 tccccggaat cggcgcttca atccgaatat ctttagctga gagactgagt ttaatatcat 2711821 cggacaagtt ggtgatttta ttcaccttta cacccggttc aggatgcact tcaaatctcg 2711881 tgacagacgg accctgggtt acatggacca cattggcgcg gacattgaaa tttttcaagg 2711941 tcaaatcaag aagctgacgc tgttcttcga tccacgcagt atcatcttga acctgcgctg 2712001 gcgggacatc aagcagtgca acattcggaa atacatagct gccgcggcgc tcctctgctt 2712061 tttgctgttt atgcgtatct cttttcagca tcatcacatt aaaaggaacg gatggccctt 2712121 tttgagaaga tgcgctttgt tcagtccttt tctcctgtac accaggcctt tttttcggct 2712181 cttctgaagc ttcgcgaggt ttgtctgcgc gaatttcctg ccggttttca agagttgcag 2712241 tagacgattt ggaaccctgc tccatgtgtt cagttttctc aagctctgta tggctgtctg 2712301 gctgaacatc tatcttcgtt tcctgagcct ctcccagggt gtcataatga ttatttatta 2712361 tgctttctga tggctcttct gattcttttg ccacagtttc tgcttgagcc agagcctctg 2712421 atgaatactc atgatcagta aataaaggct cttcctgacg aatgtccatt tgttcttctt 2712481 gaacgaacgg ggactcagca ccttctgccg cgttttcatg atgattgtat actgggctgt 2712541 ctgacggctc ttttgctttt tcatcctcag atactgcctc tgtctgagat tcaggagctg 2712601 tttgctcttc atcaagttca gcggagaaaa caggctcttc aaatttctct ggctgctgct 2712661 ccctttgttc ttcctcagcc gttgcaggct cttcgcggcc tacttcactg tctgaaagcc 2712721 cttcagccgc cgtatctgtg agcatctcag gcggtgtttg ctcttcggct tgttcagctg 2712781 ggaagaaagg ctcctctttt tccggctgtt gaacgcctga ctcaaatggc actttgttac 2712841 ctgacggctc ggctggccgt ttcgccagcg cctcatcatg ctccgtatcc tttctgttta 2712901 aaacgccaga aggctgtttt tcaaattggg tatccgggaa gaaaggactt tctattttgg 2712961 aatgcgcctg tgtgtctgaa gcaggatagc cgcgttcacg ttcgatctct tctgacagca 2713021 gtgttacctt ctcttttacc gatttatccg gttcgttcaa tgtttcagaa ggctttttcg 2713081 gcacatcctt tttaacagat ggtttttgat tgaatccata gacaggcgaa gggatatttg 2713141 tcggtttaaa cggtttcttc gccggctctg ctgcttgata tgtatgctgc tcttcttcat 2713201 ttctgggacg ctctctgtaa ggtgcagcac ttggacgagg cgcggatttc ggttcgtccg 2713261 atggtgtgcg gcgccttctc aggtcatgat ttttgtatcc gtcaggcacg actggaaaac 2713321 ggaatttgcc ttttggatat tcataatata ttttaggatc ttccaatctt tttaattgtc 2713381 cttcaggatg atgtacttct tgttgctgcg gaatttgagc gggttttgtc tcccgttcag 2713441 catcctcttc gctttcgcct aaaaacaaat caaaaaattt atgaagccaa ctcataattt 2713501 atctctaact cccttatagt tttctgggac ggtttttagt ataccactgc tggtcggccc 2713561 agaaaagatt aagctatcag cagaaacaaa gccgctaaac aagggcttag cggcttttca 2713621 catgattcgt tttttttggc ggatttatgg gagtctaaaa ctgaaatgcg tctcccgcct 2713681 catagtctcc ttctaacaca aggattcctt tttcagcagg ggcatccggc aaatcaagct 2713741 ctttcgctga gcagatcatc ccgcttgacg gaacgccacg aagctctgca tccttaatga 2713801 caagtccgct aggcatcaca gcaccgactt tggcaacgac aactttttgg ccttggtcaa 2713861 cgttaggcgc gccgcagacg atctgaagcg tttcttctcc tacgttgact ttacatacgc 2713921 ttaatttatc cgcattcgga tgtttttctt ttgattctac ataacccaca acaaacttcg 2713981 gagataaatc aacgactaat gtttcttcaa cgccgtttct gtttaaaatc tcattcacat 2714041 cttgcacgaa tgtttctgag agcgcaacag ggccgttttc atcaatggtc aagtaagaag 2714101 acgcattgaa aatgttgaag cccgttgttt cttttgtttc gttattgaaa attttgacga 2714161 cgtcgccgtg tttttcatag cctaattgtt cgcgtgtcac atcttgaaga gagatcagga 2714221 gcgtgtctcc cacaccttct ttattataaa aagcgttcat aagtaaaaat cctttctaat 2714281 cctttttcgg acggcttttc gccaggataa acaccggttc cagctttcct tcattgtaca 2714341 aaaatgatag ggcggtaatc gggacggtgc cgcctgcaaa gaagctcatc gacatttgtc 2714401 ctagaatatc ataccccgat tcattccgga tgtcagcaag aatcaaaacg tcctgatgag 2714461 gaacagagat cgccagctca ccttctgcat gctgcttata ctcatttaag atcgcttcgt 2714521 tcaaaatccg gcttgcgtcg tatccgtcgt ttgccctgaa gaaataaaag taattgccgg 2714581 caaccgtatc ctctttgaca accgtcggca gggaacggag attaaatgcg gccgtctctc 2714641 tgatccgctc ttttgtccag ttttctttct caagcatgcg ctggtcaatt aaacggtagg 2714701 ttttcccgag atctagcgcg taataaattc ttgtctctgc ggtatgatcg tcataaatga 2714761 gcgggatatc ttcgctggac ttgtccggga aggaagtcga gcggatgacc ggataaatgc 2714821 gagtttcttt cccggtcatt tcctgagcct tcccttccat tgccgtcatc gcttcggaga 2714881 catagtacac gatctcatca atggcttcgt cttttttcag ttcccatttt gcaataatcg 2714941 gcggcaaatc gagtgtaatc ccttttttag tcgtttgatc ctcaacacgg agggtgtctt 2715001 tttctctgtc aaacagaaag gagcgattct cgtgctgaag gcgctgcttc agtatatctg 2715061 acagcttcct tgaggtcatt ttcaaaccga tgtcctcctt tacgctttag cgagagagtc 2715121 tgttaaaaac tgttcaattt cttcttttgt tttgcggtct ttgctcacaa aacgatttac 2715181 ttcttttcct tcattaaaca ccacaaagct tgggattccg taaatttccc actctgcaca 2715241 tgtatcaatg aatttgtcac ggtctacgta gtagtaggtg aattcaggga aattcgcttc 2715301 cagttcaggc aggaaaggct ctacaaaacg gcaatccggg caccaatcgg ccgaaaacat 2715361 aaatacagac caatcatcct ttaccgcttt ttccagctct tgagttgatt caattttttt 2715421 catttcatat ccctccagtt gtttatgttc ttacatgttt tttatcgata ctcgtccatt 2715481 tggatcatac caaactgctt gaggcaaaac cacttatatg caacgaatga atatgtaaga 2715541 ttggctttcc cattatcatt atcatatttt atttgcatta tcaagctcgt ttcgtttaac 2715601 atcgtgtaca tgagggtgaa atttacagat ggatatacat aaggagggat ttttattatg 2715661 gagtttatcg tctatttagc aggagaaatc cacagcaatt ggcgcgagga aattaaagaa 2715721 aaaacaaaat cactgaagct cccgattacg tttgttggcc cgatggagaa tcatgaccgc 2715781 tcagacaata ttggtgaaga aattatgggc gtacagccaa atgccgtttt aaaggatgac 2715841 aaagcctctg acatcaacaa cttcagaacc gccgtcctga tgaataaagc agactttgtg 2715901 atcgccctgt ttggcgaaaa gtacaaacag tggaacacgg caatggatgc atcatatgcg 2715961 atcgcaaaag gaaaacccct gattatcatc cggccggaat cgctccacca tcctttaaaa 2716021 gagctttcca ataaagcgaa tattacggtt gaaaccgtta accaagccat taaggccctt 2716081 tcctatctat ttgaaacaga ataagaaaaa agcttgtcga tccgggctta ctgctcgttc 2716141 aacaagcttt tatgaaacct acatattttc tttaatcgca tccactgtct gcttatcgca 2716201 ggctgttaca agtttgatga gcatttcttt agcagcagca taatcatcaa tatgaatgat 2716261 agtagcgttt gtatgaatat agcgggaaca tattccgata accgctgacg gcacaccgct 2716321 gttcgaaata tgaaccttgc ctgcgtctgt tcccccgccg gatacaaaat attgatatgg 2716381 aatatcatgc gtttcagcca tatcaagaac gaattccctc attccgcgat gcatgactgt 2716441 cgttctgtca agaatgcgca gcaaaaagcc ttttccaagc tggccgaatt catttttgtc 2716501 tccgctcata tcgtttgccg ggctggcgtc aagggcgaaa aacaagtccg gtttaatcat 2716561 atgagaagcc gtctgcgcgc cccttagccc tacttcttcc tgaaccgttg cacccgcata 2716621 gagtgtattc ggaagctctt taccgtgtaa ttccttcaga agttcaatgc ttaagccgca 2716681 tccatatctg ttatcccatg cttttgataa aattttcttt tcattcgcca tcgtcgtaaa 2716741 cggacaaaca ggcacgatct gctgtcccgg tctaatgccg attttgatgg cgtcttcctt 2716801 atcatccgct ccaatgtcga tcatcatgtt tttgatatcc atcggtcggt ttcgctgcgc 2716861 atctgtcaat aaatgcggcg gtatgcttga aatcacaccc ggaaccggcc cgttatctgt 2716921 ttgaatttca acccgctgcg caagcaaaac ttggctccac cagcctccga gcgtctggaa 2716981 tctgagcagc ccgttgtctg taatggatgt caccatgaag ccgacttcgt ccatgtgccc 2717041 ggctaccata attctcggtg cgtcctctgc gcctcgtctg actccgaaaa cacttcccag 2717101 tctgtcctga acgatgtcat ctgcatattt ggctagctcc tgcttcataa aagcacgaac 2717161 ctgatgctca ttgcccggcg cgccgggaag ctgcgtcagt gtttggaaaa gcgctttcgt 2717221 ttcttgattc atgttttccc ctcatttcta tgtagtcctt ttattttatt agaaacaatg 2717281 aagttttcca agcactctga cccaatctgc tcgatcagcc gcgtattgct taacaggatt 2717341 tggctgtttc tgtataatga aaagtacgat caaccaggag gtgctttatt ttgaaattgc 2717401 gtcatcttct tttaggagca ggacttggaa tttgtacggc tgtcgttgtg agacaatatg 2717461 tgatgaagcc ttatatttct tcagaaaaag cgcttcgaat tgtaaaatct gcttttaagc 2717521 agcggggccc gattgacgga tcatggattt acacccagcc ggagccctac aatattaacg 2717581 gagaaacggt acaggtatac aaaaccggca ttacacgatc agctttcgga gaattagaac 2717641 agtatgaagt catggtggat gcgaaaacgg gagaaattgt tgatgtcatt gatacaatcg 2717701 cctcttaaca ccggacaagc aaaaaataga agccgctgcc tatgcagcgg ctctttttta 2717761 ttatatcgcg cgaatcggtt tgtataccgg ataccacatc gcatcctgca ctgcctgtat 2717821 aatgtcttca ggctcttccg tagcgacgcc ttccttcatt gcggtttttg caacttcaac 2717881 agcaacggtt gccgaaacag tgcgcaaatc ttcaactttt ggaagcatcg gcgccccagg 2717941 caccccgaca ttgaccatac ctgcgattgc ccgggcacat gcttcaaaca tgccgtcggt 2718001 aattaatttt gattttgtaa caatcgttcc aagaccgaga ccagggaaga caagcgcgtt 2718061 gtttgcctgc ccgatatgat acgtaactcc gttatattca actggcggga acgggcttcc 2718121 tgtcgtgatc agcgcacggc cttctgtcca ttcgattaaa tcctccggct ttgcttcaga 2718181 aagagttgtc ggatttgaca ttggcaaaat cgccggccgt ttcacatgtg acgccatttc 2718241 ttttacaatt tcttcagtga aagcgccgga aaccgtagat gtgccgatca ggatcgtcgg 2718301 tttcgcctgc cgaaccactt caagaagatc aatgcctccg ccgtctccgt tccgctgata 2718361 atccttcact tcatcagccg aacgggcata cggcttttgg aaatcaagaa gctgatccat 2718421 atcatctgtt aacagcccgt tcctgtctat gcaccagaag cgcttgtatg attcttcttc 2718481 actcagtccc tcgcgcacca atgcttcccg cagctgttcg gcaattccga ttcctgccgt 2718541 tcccgctccg aatataacaa ctctgtgatc tctcagcgga actttagacg cttttgcaca 2718601 ggataagact gcggccaaag aaacagcgcc agttccttgg atatcatcat tgaaggtaca 2718661 cactttatct ttatagcgtt tcaaaatgct tcgcgcgttt ttcgccccga aatcctccca 2718721 atgcagcaat gcattcggaa atgtttctct cgccagcgca acgtagtcgt caataaattg 2718781 gtcataacgt tccccgcgca ctctggaatg ctggttgccg acataaagcg ggtcgttcaa 2718841 gaggctctcc tgatttgtcc ccgcatctaa aacaacagcc agcactctgc tcggatcaat 2718901 gcccgcagcc gctgtataaa ccgccagctt gccaatagaa attgcgattc ctccgacgcc 2718961 ccagtcaccg attcctaaaa ttccttccgc atcagttgca acaattaaat cgatcgtatc 2719021 gctttgatct ttatactgtt taaaagcttc tttcataccg tccgggtcat cgattgacag 2719081 atagagccct cgtggttttc tgtattcatg gctgtatctc tgaattgccg ttccgactgt 2719141 cggtgtgtag acaatcggga gcatttcccc taaatggtca tttaacaggc ggtaaaacag 2719201 cgtttcattc cgatcgtgca gcgccgttaa atagacattt ttgctcaaat cgtcaggctg 2719261 tgcggaatat tgttcatacg ctcttttcgc ctgatcatca attgttaata ccttgggcgg 2719321 cagaaagcct tttaaaccaa gttcttttct ttcttcctca gtaaaagcaa cacctttgtt 2719381 caaaaaagga acagagagca cttcaaggcc tcttaatgtt gtttgaatgt ctccttcgtt 2719441 tgttactctg aattgtttca ccctgcctct tcctttctga gcataatagt actaggtttg 2719501 cattattagc cggaaaacat gcagggtaaa cataaaaata tgctatcgct tcattcgctt 2719561 aactgacttt ttgatgcttc cgtcctcctc ccattgaagg gcgcgatact cggcatcatg 2719621 gtaaaaaata aaccaagcat ctttttctgc tgcgaacgcc tgccatttct gcttttgcgg 2719681 gatagaggtc atcggataat catcgtaagc cagcacccat agcggattgc ggtgggcatg 2719741 tgtcggcatc agatctgcca tatgtacggc agtttcaccc gcatcctcgc atatcaggac 2719801 actgtgtccg tcgctatggc ctccggtgtg atgcattgta ataccctctg tgatcgttaa 2719861 ggtgtcttca aaggttttga cttggccagc tacagcctcc caattttctt tccaatacgt 2719921 atttttcgac ctgatattcg gatggcgcat ttcgtcccat tcaacagctg atgtataaat 2719981 cactgcattc ggaaagacag agacgagccg ttcaccttca tattccgtta aaccgcatgc 2720041 atgatcaaaa tgaaggtgtg tcattgcgat cacatctata tcggcaaccg ttaatccgag 2720101 tgcagctaat gagggtttca cattcgactc ttgtgtcacg ccatagtttc gtttttgttt 2720161 atcagtcagc ttgccgtacc caattccggc gtcaatgatg atattgagcc catccttttg 2720221 aatcaaaata gggtctgttc ttagttcaat ctggtttttt tcattgactg gatatttttt 2720281 agaccaaagc ggctttggca caacgccgaa catggcgcct ccgtccatat gcgtcacgcc 2720341 tccgtcaagc caggtcaacg tgatgtttcc aattttcatt gtttccattt tcaccccccc 2720401 ctatcatcat ggtagcaaac ggcccataaa aaaaacagac tcctgtcaga gtctgtcttt 2720461 acgttctcca ttcaacctca gcccgataga tcggctggcc gagtgcagag aatttttctt 2720521 catattctgt cataatattg ccttccagat tgctgttatg caaatcgaga ctgacgtatg 2720581 tcagcaggag gccgtactca gagaagctct tcaaagagta ctcaaataaa cctcggttgt 2720641 ccgttttaaa atgaatcgat ccgcctttgc ccattacttc ttcatatttt ttgaggaagt 2720701 gggaatatgt caggcggcgt ttttcatgcc gtttcttcgg ccaaggatca gaaaagttca 2720761 agtagacccg tttcacttcc cccggctcaa acacatccgt cagcgtgtcc gcatctatat 2720821 tcagaagctt tacattctgc gcttcgctgt cttttacttt ttggacggct gtcacgatga 2720881 cgcttttaaa taactcaata ccaatataat tgatgtcggg attttgtttg gccataccag 2720941 aaataaattg gccttttcct gtaccaacct cgatatggat cggattgtcg ttgccaaaca 2721001 ctgtgttcca tttcccttta taatcagcag gattgctgat ggcaatatct gcgttttcag 2721061 ccaaaaagtc atcagcccaa ggcttgtggc gcattctcat atgattgaca cctctatcta 2721121 ttatttcgac taacaacata ccatgaatta aaaagacccg caagctcgtt tttccagtgt 2721181 atctctctta aggccgagcg cataaaaaaa gagggtcccg tctgctggaa cactcctttc 2721241 ccatgtataa aaacgctctg ttttgaacaa tttaacccgt atgatactga agggatgtgt 2721301 accgttatgg gtttacatta tgagcatcaa gttcatttat tgaaggatat attgactgac 2721361 catcaattgg actgctgcgg aacagtcgca gagtacgagc agcttgagcg tgtgattaaa 2721421 tcactgatgg caaacaccga gcttgattca aatttcaaaa acgtgcttga agatgtttac 2721481 cgctacagcc aatcaggaat atcgtccaaa tccatcgact cacacataca agagcatcag 2721541 aacagcctgt ctcaatgggt agagcaaatg gattcgtatt cctgattaat caacaattcg 2721601 tttcatgagg atatgcagct cttccattgc atcatgaaat tccttatcat tgccttttgc 2721661 tttatgccag gcaatgaaag taattgtttc agataacaca taccaagcca ttcgcaaccg 2721721 aaggctttct gtcagctcta tgccgtacat gctcagccag ctctcccaag ctggcttttc 2721781 gacgtagtgg tacagcaaag gcccgaggtc catcgccgga tcagcgatca tggcgccgtc 2721841 ccagtcaatt aaatacagct ggttgtcttc agacaatagc cagttattat gattgacatc 2721901 acaatggcaa acgactttct caccgaaatg cacttcatgc aggtgttctt ccaaatactt 2721961 gatcccttct tgaatcagcg gcgaagattg ctgcacagca aatacagcct gcttcagctg 2722021 agacaaaaga gcccccgggt tcagcggttc ttttccaagt ctcttcagca tgtccagcaa 2722081 ggcttttgat gtgtgtattt tacgaagcaa ttcagcaacg ggccgtccgc tcatgtcttt 2722141 aggcttcagc tctctgccgg tcatccagtg ctgggccgta atgacgtccc cattttccat 2722201 ccgttttgtc caaaccagct tcggaacaat gccttcggcg gataaaacag ctaaaaaagg 2722261 tgagctatta cgttttaaaa aaagctgctg cccgttatgt ttcgcataat atgcatctcc 2722321 tgtagctcct ccggcgggga agatctccca atcgctacct agtaattgtc ccaaccagtt 2722381 catatcaatg ttcaacccat catttcttaa aatattttag aattaaggct aatcgtttct 2722441 agtctatcca gcgaatgcct ttttcgtacg aatcgtataa aaataaaaaa gacagctatt 2722501 gagagtctca tatgctaatc aatagccgtc ctttaaattt tagcgctata gcacaaactt 2722561 cgtcaagcaa aactcttaag atctgatgct aaatataaga taaccgttcc gatgccgttt 2722621 actgcaaccg ttttcttgat ttctgttggg tcttcctgaa atcctgatgg atcacataaa 2722681 agccgataag gtatgtcgtt tggcagcctc cactcgacgg agtctggact cgcgtgatgg 2722741 ataacaatga tatctttcca ttcgtcaacc tcgtcaagat cataaagcct gtatgcgata 2722801 aggtgttctt ttagcgtcaa gcattcaaga tggcgctgga tgtctgcagc ggacctaaga 2722861 cggaatgcag gatgcgcttt tctcagcgag atcagcctgc ggatatagtg aacatcttct 2722921 ttgaatgttt cacggcgatc ccagtcgagc tggttgatgc tgtcactgga ttgatagctg 2722981 ttttccactc cctgcttcgt ccggaaaaat tcctggccgc tgtgaataaa cggcacccct 2723041 tgggcaagca aaataatcgc ggctgcaagc ctttgcctgc ttcgctttcg gctgtcattt 2723101 tcttgaggaa gcgcaaagct cattttatcc caaaaggtgt gattgtcgtg tgattcgaca 2723161 taattgatgg actggcttgg ttccggaaca atcggtgcta atgccttcca tccggaagac 2723221 ccggcaattc catgcatcac agcttgtgct gattcaccgt tgccgagcgc aaaccctgtt 2723281 gccttaaggt gaaaggtgtt cccttttaca gcgtcacgaa acatatcatt aaaaaagccg 2723341 atgcccggca ttcttggcgc gttcgccaaa gcagctttct gttcatgcgg cagcggtgta 2723401 gccaggtccc acccttctcc aaaaagcagg attccgggct ttgccttagt tgctttctct 2723461 ttcatataaa gcacggtgtc aatatctaaa atcccgagga gatcaaagcg gaagccgtca 2723521 acattgtatt cttcaagcca atagaccacg caatccgcaa tgaattttct tgccatcctt 2723581 ctttctgatg caatatcatt gccaacgccg gtgccgtttg atggcatccc acattcgtcg 2723641 tgccggaaaa aataaccggg cactgtcttt tcaaaggggg aattctccct cttatacaca 2723701 tggttaaaaa caacatccag aatgactcgc agaccgtgct gatgcagggt attgatcatt 2723761 tgtttcagct ctgtttttct cgtttgagga tcatgaggat ttgaggcata gcttccctcc 2723821 ggggcaaaga aatgaagcgg gttatatccc caattgtatg catcaagcgg cttctcttca 2723881 tcaactccgg caaaatcatt caccggcaga agctccacat gtgtcacacc aagctctttt 2723941 acatacgcta atcccgaaga actgccattt gcggtttgtg tatcagtttc cgtcagcgct 2724001 aagtattttc ccttgtttat catgccgctg ttttcatgga tggagaagtc gcgaagatgc 2724061 gtctcataga tgacggcatc cacagggtgt gagaatggtt taagaggagc agtccatttc 2724121 atttgatccg ggcgcaagac gacgcccttc tctccattta cagtcacagc cttggcatac 2724181 tggtcaactg tttccatcca ttctgaattg ttgcagatgc aaaacaaata ctcatatccg 2724241 tgaaggtcac ctgtgaccgt gacggcatag acgccttttt ccaagcgagt catttggaat 2724301 gtgcgcccgc ttttattggg gtgtgaaagc ttgacagcag ctgaggttgc agcaggcgcc 2724361 catactttaa atacggtatg atccgcggta taaacggcgc ccagctctcc gtcataataa 2724421 aattcgtcat caaacgctgc cgtccggatg accgcgccaa tttggagatc cgttttgtgg 2724481 ccgctggatg ctctgacgca atggattttt ccaaatgtca caggatggtc ggatacgcag 2724541 acgtacttgt attttgcttc aagggagtat tcctccctga cagccagagg aaaatctgtt 2724601 atttctgtct caagccgaaa cggcggtgtc atgatttcct tttgttcagc aggaatcaga 2724661 acagtaatga tattcatgtc atcgacatac gcttcgaagc tgcggcggat gctgaccatc 2724721 ggaagctctc tcctccaaac acgtttatgt tttgattctt aggggtgaag gactagatgc 2724781 cagacgaaac ggggtagtgc ccatgatttc tccgtcagca tggaacggga ttttgtcctt 2724841 cgtgtaaaat gtaatgtcct tcgctttaaa catcgtaacg ccatccatct ttgtatgttt 2724901 tccaaatgcc atgagacata aaagccaata ttttttcaaa aacggctggt tttcaacgat 2724961 tacgatatca aatgtcttct cgcgcggatt tgctaggggc gccgccttca tgcctccccc 2725021 gtaaaacgga tggttggata caacggcaaa ccagacatca tgaaattcgc gcgtctcgtc 2725081 ttccgtcgta caagctaatg taaacggctt aaaggttgcc gaagcgtgca aatgagaaag 2725141 cggatacaca agaaatcgaa ggcggagaaa aagaaaaacc cgtctcaacg gaaattccat 2725201 cgccttttta ttgacatatg cgtcaaaccc gatcccgata tgattcataa aataaagaat 2725261 ctgtgattta tcctgaagga aattgacgct ccctaaatga aaggttcttg ttaacgggcg 2725321 ctttaccttc ttgatttcct gtatcagatc gattttttta atagagaacc ctcgcgaaaa 2725381 atcattatac gcgcccgccg gcacaaagct cagctcaata tcgtcaacat ctttcagccc 2725441 gttgacaact tcatgcatgg ttccgtctcc gccaatgacg atcaggcgct tcagcttata 2725501 ttcctgtatc gttgaaatct gtctggcgag cacctcggcg tgtcccggat gttcagttaa 2725561 aaatgaacgg tgctcaacct ttcgtttgat caattctttt tgaatggact tccaaacacg 2725621 caggccgttt cgatgtcctg ctgtcggatt aataataaaa aaccaatggc tcatctttct 2725681 cacctgctta tgttatgaga aaaccgctca aatcgttctc ttttactcca gccactcctg 2725741 tctgcgatag gagtcagaca tgcagtaaga caatagagcc tttgcagcct ttacctgatg 2725801 atgtttgatc ggagcagtgt ttttcttctg ccgctcaatc cattcttccg cgctccgctt 2725861 atccgctatt tctaagccgt atggcggctc cgggtaatcg atgtacgacg ttctgctcag 2725921 aagcaatttt cgaaccggaa tctcagcctg tttttccttt acgatctttg acacaaccga 2725981 gtccgtacga aacaggctaa gccctggatt taacactgat gcagtctgag aggctgtttt 2726041 cttgtcccaa aaacgatttt tagaccctat gtagacactg tcttcctcag cctctaaaaa 2726101 agaaacgcaa taaatttcca gaggagaaat aatcacaatg cttaattcaa ccgccgcctg 2726161 ctgaattttc agcacaggct tatacataat aaaataagaa tcaggcagct gctgggtcag 2726221 ataacgcaaa atgcggtcct gcttcacttg gtttgagagt tgagatattt ctgaaagagt 2726281 agagcttgcc catttgagct gaaaatcata taaatgcctt ttataaaaag aagcaagcgc 2726341 caccctgctc ttcgggagcc ttacatgaat atcttcttcg tcctcaaacc attggtgtct 2726401 ctcttcttgt atatcggctt ttatctcttc ttttcttctt ttcaatgaaa atttttttcg 2726461 tttctgcacc ggttccggtt cttcagcact ggcttgcctt tcttcatgct ggcgctccgc 2726521 tgcttctact agtgaaagcc agcgctcttt tttcaaacgt acaaactggt tgatataatg 2726581 gtacggatca agctcatatc tcgatatata atcatgaatt ttgatgattt gtgccatgtt 2726641 tgtttctcca ctccgcaatg aattaagata attgaaattt gaatatttcc tcgtattttg 2726701 gtgattggtt caagtgtatt tgaaagagcg aaaatcgttc agccatcatc gaaacctcgc 2726761 cgctttcaaa cggaacatga gctggaaatc catcttcgcc tgtccatttt cttgccagcg 2726821 tcatatgagg atgatacggt cttttttcca cttgaaagcc ggcctgaagt acagcctgct 2726881 tcgtatgttc ccgcagtcta tcaagcgttt tgtttttctt tggctccaga tgtaaaacgc 2726941 gcggctttct gcggtcgccg aatacatcta tcttgccaaa cttaattgaa aatggatcaa 2727001 tttctgaagc aatctctgct agcgaacctt caagcttctt tatttgtgtc tcatccgccg 2727061 ctccgagaaa aattaacgtg atatgatagt caagcgggtg cacccatttt tgaaacgtca 2727121 atatcggttc gtttttcgca gcctggtaga tcggatttgc aattccctca ggtatgggaa 2727181 cgccgatgaa ataatgaggc cgtatatctg gcatccgtct gacactccct tctttgacag 2727241 ctattatttt atcaataaag aggctgtgcg gatagaggaa cagtgtatga aaacactctc 2727301 gcacaaacgt ttattatgtt aggatattat atgacacttg ttttattcag aaaggaatga 2727361 caatgttgaa aatcgttgca aacacagctg atctgatagg agatacaccg ctagtgagat 2727421 tgaatcggct tcagccggaa aatgcggcac aagtctattt aaagcttgaa tttttcaatc 2727481 cgagcggcag tgtgaaagac agagccgctt atcaaatgat catagaagct gaacaaaacg 2727541 gtttactcaa gccgggatca gttattatag agccgacaag cggaaatacc ggcatcgggc 2727601 tcgccatgaa tgcggcagca cgcggatata aagcaatctt agttatgcct gatacgatga 2727661 cgaaggaacg gatcaaccta cttaaagctt acggtgcaga ggttgtatta actcccggag 2727721 aggaaagaat gccgggcagc atcaaaaaag cgaaggagct tgccgaacaa attccgaaca 2727781 gctatattcc aatgcagttc gataacactg ctaatcctga tgcgcaccga aaaacaacag 2727841 cgcctgaaat cgcccgggca atagaggaaa tcggaaaacc gctcggcgct tttgtagcct 2727901 cctctggaac gggcggaacc attaccggaa caggtgaggc gctcaaagag ctttttccgg 2727961 atatcacggt tcatgttgtt gagccagcgg gttcgcctgt attatccggc ggaaaacctg 2728021 gcgcgcataa acttgtagga acgagcccag gctttatacc gccgatttta aatgaagacg 2728081 tttatgatga aattatcaaa atctctgatg aagacgcgta tacgacgaca agacggcttg 2728141 ctgctgaaga aggaattctt gtcggtcctt catcaggcgc tgcctgcttc gcggcaatcg 2728201 aaacagcgaa acgcctctct cctgacaaag ttgtggtctg catgacagct gatacaggag 2728261 aacggtactt atcaactgat ttatggtcat ttatttaaaa aaaggactgg cttcagcaga 2728321 agccggtcct tttattttgc aagctcgtaa atggcctgag catataacgc tgtcgatctc 2728381 agcaggtcat caatttcgat atattcatcc ttttggtgtg cgctgtcagg gcgtccgggg 2728441 aacagcgggc cgaacgcgac accggctttt aaggatctcg cataagtccc cccgccgatt 2728501 gagattaaat cagctttttt acccagctgg ccttcataaa ccttttgcag ggttttgact 2728561 aacggatgat ctgcggacac gtgatgcggc ttgctgtctt tgaattctcc cagctcaaat 2728621 tcagatgcgc tttcgaatgt atcgcggatc actttgcttt ctgctgtcac aggatagcgg 2728681 atattgatcc cgagctcgcc tccttgccct tctttatagc gcagtgttcc gacatttaat 2728741 gtcagctctc cgctgatttc atcctcacag tcgatgtcca gtttttttcc tcttgtatca 2728801 cctgagaact tatctgtcac aacttgcaca aaccgctttc ctgcatcgtc aagctcagtc 2728861 tgctggagaa attcgcacaa taaaatgccg gcattgatcc cattgttcgg ttccatcgca 2728921 tggcaggaaa gaccgtacat acgcaaaatg agctgtccgt tctctattgc agcttcccct 2728981 ttttggtccg tcgtgcggag catgtcttta aatgaagaca gaatctcttc atttttcggc 2729041 ccttcaatga cagcttccgc agcgtcgggc accatgttta agcgaaggcc tgattgaaac 2729101 gagacaagca ctgcctttgg ttcagcttga tttgggcggt gcggaataag taaagaagca 2729161 tcgatgatcc ctttttccgc attaatgatc ggaaaatcgg cgtcaggcgc aaagcccatt 2729221 gttggcattt cttcatgctt gaaataatgc tctacgcatc tccaatcact ttcttcatct 2729281 gttccgataa tcattctgac tcgcttggac aggggcaaat tcatgtcttt cacgattttc 2729341 agcgcgtaga atgccgccat tgtcgggcct ttgtcatcaa tggcgcccct tgcataaatc 2729401 cgtccgttgc ggatttcagc tgaaaatgga tcactcgtcc acccatctcc cggcggcacg 2729461 acgtcaacat ggcaaagtac gccgataatg tcatcgccct ccccccattc aatatgacct 2729521 gcgaagccgt caagattttt tgttgtaaag ccttcttttt ctccaagctc cagcaatgaa 2729581 gtcaggctgg catttacccc ttctccaaac ggtttaccgg gtccggcggt tgtttcgtcc 2729641 atgacactgt tgattctcaa aaattcctgt gtatcacgaa ttaaatcctc tttttttctg 2729701 atcacttcaa cttcccagtt cataatgatc ccctttccgc aagaaatgac ttgcaaaaac 2729761 caaataaaac gaataatatt aatggtgttt tgttaaaacg ttcgtaattg gaggatacta 2729821 tgtttcatct aaaagagcag caaacatcca taaagcaaga aatcatagca gggctgacga 2729881 cctttttcac aatggtctat atcgtcgtgg tcaatccggt cattctggct aacgccgggg 2729941 ttcctttcga ccaggttttc accgcaacga ttattgcctc cattgtcgga acgctgtgga 2730001 tggccctggc agcaaattat ccgattgcta ttgcgcccgg catgggcttg aacgcttatt 2730061 tagcctttca tgtcgtaagc gcaagcgatg gcggcatcac gtacgcaaca gctttcagcg 2730121 cagtatttac agcaggggtt ctcttcatta ttctatcgtt aacgccttta agaaaacaac 2730181 ttatagaagc gattccaaac aatttaaaat acgggatcac aacagggatc gggctgttta 2730241 ttgcttttat cggtttgcgt caagcgggaa ttgtggcagc tgatgagtca aacctggtca 2730301 ctctcggcaa tctgcattca cctggtgtta tcttaacgct ggtcggcctt ttgatcagcg 2730361 tggtcctgat ggtgctgaat gtaagcggcg ctttatttat cggaatggca gctaccgctt 2730421 tgatcgcctt tttcaccggt cagctccatt tttcaaaggg atttatgtcg cttcctcatt 2730481 tgccggaagg attgatgatc tcaaatccat ttaccgcttt tggcgatgtc attcatcacg 2730541 gcctgtacgc tgtcgtcttt tcttttctat tagtcaccat ttttgatacg acaggcacga 2730601 tgatcggagt tgccgagcaa gccgggctga tgaaaaacaa caagctgccg aacgtgcgaa 2730661 aagcgctgct tgctgattca accgcgacga cagtaggagc tgttttcggc acaagtccga 2730721 cgactgcatt tatcgagtct tccgccggtg tcgcagccgg gggaagaacg gggcttacgg 2730781 ctttgactgt cgcggtgatg tttgcggctt caatgttttt cagtccgctt gtcagcgcct 2730841 tgtcaggtat agccgccatc acctcgcctg ctttgattat cgtcggcagc ctgatgatgg 2730901 gctcagtttc caatatgaac tggaaagaga tggacgaggc atttcctgcg tttctcgtca 2730961 ttctagccat gcctttgacc tcgagcattt ctacaggaat cgcgcttggc tttatttcgt 2731021 acccaattgt aaaagcggcg cggggaaaat ggagagagat tcatccgctc gtcatcgttt 2731081 tcgccattct gtttttcatc cagctgttta ttttataagg atagaccaaa aaacccaaac 2731141 gtcgccgttt gggtttttta tgtaaacaat aaagagacag cggccgctaa aaaacaacag 2731201 gcggcaaacg catagtgcag gatgttgata cagctttttc tggcccgata atattcatca 2731261 ctttccttat cggtgccaat taaaaaaggg gcatccatga ccttgtcaaa aataagcgtc 2731321 aggatataac ggcaaacccc tgtgtatacc agcagcgcaa tcaccttcag ccaaattggg 2731381 gaaacaaata tgagaacagt gaaagctgac agtagcatgt acatctgcct tgcatactcg 2731441 ccattcctca gcataacttt aaaaaacaac tccttatagc ctgtgcagat cgttcgtctt 2731501 ttaaatatcc tttttgaatt tcggtataat aatggttttc ttctcatcct gtcttttact 2731561 tttggcattc ccgcctcctg actcatcatc atcacaagtc ctgcaagggc aagcctgctt 2731621 tttttctctt cagtcacctc agcttcaaaa gccgtgaacg aggctgtctt tttcaaactg 2731681 cggataactg agaaaaacaa aaataaaatg ccaaaaagcg caagcaagtg ccgctcagta 2731741 aaaacaatca ggatagcaga accagcaaaa agaatagctc tgacaagggt atcgccaatc 2731801 catctcgaaa tggagcgcgg ctttctgatc ctgtcttgct ttaaggataa aaagaatata 2731861 tgaaggccaa acaaataaca caatagagca gtgctttctg cgaatgtgat gagaacagaa 2731921 tgactgatca agggaaggac aatgaaaaag agaagcagcc atttagccag cgtggccaga 2731981 aaagaataca aaagcgcata ccgtttgagc tgatagatga tttccttctt ttgcagcaaa 2732041 aacactttgt ccgcttccat taaaaatgta cgaatcgaac ctgtaaacat gatcagcaca 2732101 cacacagcat acagccatct ccattccgcc acttcagacc actcataaag aaggcctctt 2732161 ccgttcatca aatcaatata ctgatagatg acaaaagcaa tcgccggcaa aacgatatag 2732221 agagcgactg tccagtcaat gaccgcatgc aacactttaa actgatactt ataatagtca 2732281 aacagccttc gaaaaaagag cgtacgcccg ttcatagccg atcaccttga actgccttat 2732341 aaaaacagtc aagcaatgac tgcccctcta atccggtctt gtcctgaaca tcttttaacg 2732401 tgccttggag aaataatgaa cctttctcaa tcatataaaa ccggtcacag attttttccg 2732461 cggtatcgag tacatgcgtg cacataagaa ttccggctcc acgttctttt tcagccttaa 2732521 gcatgtccac aaagcgtttc gtcgatatcg gatcaaggcc gataaacggt tcatcaatca 2732581 catacatatc cggcttagag agaaaggcct ggataagcat tagtttttgc tgcatgccct 2732641 tcgaaaaggt gacaggcagc tcatgtttga catgatctag cgaaaacgtc tgcagcaggc 2732701 tttgggcccg atgcgcaaat tcactctctt caatgccgtg aagtgtgctg atcagatcca 2732761 aatgctccca cagcgtcagt tcttcgtaga aggacggatg ctccggaata tatgcaaatg 2732821 aacagtcgtt ccaggcaata tgccctttaa aatcttctga aaggccgagt atcgccttga 2732881 ttgcggtgct ttttcctgcg ccgttagctc cgatcagtcc aaccagttcc ccttttctga 2732941 cttccagaaa aacatcggtg agcacttttt ttcggcttgt atacccggcc tgttctattg 2733001 aagcttcaag caaatttgtc aaaactcact cacctccaaa atttactacg aaatagaata 2733061 aaaaaagttt ctttaaccat aataatattg agccgaaata catagtaatc caacaaggat 2733121 ggctgcccaa cgcgaaattg gaaaaaatta ataggagtta tccctagatt catcactgca 2733181 atatcgtgta taatgagggc gaattatttt aacaattaca gatgtctgcc tttgttgcta 2733241 tttcgtacgc agttgatagt cgtgagttgt ggttagtcaa gtccatccga tcttatgata 2733301 gggagtggtt ttttgaaacc ttcaacaaac cgtatgctaa ctcgaatcaa atcagtttac 2733361 atgtttattc aagaaaaagg tcttgtgaca acacaggaac tggttgacga attcggcatt 2733421 acacctagaa cgattcaaag agacttaaat gtgttggcat ataatgatct tgttcatagt 2733481 ccaagccgtg gcaagtggga gacaacgaga aagaaagtaa agattacctc ataaattgaa 2733541 aattacatag ggccgcctga gagcggtccg atagataaca gggcgaagaa actactgagc 2733601 cttgtttttg tgtgcttata aataaaaccc cgcattcggt atgcggggtt tttgtcatgc 2733661 ttgcggctca tttagcaaat gaagctcttc ctctgtcagc tcacggtatt ctccgggtgc 2733721 cagagcggga tctagggaaa cgcgtcccat cgaaagccgc ttcagataaa ccacttcatt 2733781 gccgactgcc tttgccattt gcttgacctg atggtatttt ccttctgtaa ttgtcagata 2733841 tataacggta ttgccactgt cgtttgtttt gatttccgct tttgccggct ttgttttata 2733901 gccgccctct atgtagacac ccgtttccaa atcggaaatg tcttcccgag aaatctgtga 2733961 ttttaaatgg acttcatacg tttttggaac atgcttttta ggagaaagga gccgatgtgc 2734021 gagctggccg tcatttgtga gcagcaaaaa gccctctgta tctttatcaa gcctgccggc 2734081 tggaaatggc tcaaatctca tctcctccgg cgtcagcaga tcgaccactg tttgctgccg 2734141 gctgtcctca gtcgccgaca gcacgccctg cggtttattc atcataagat aaatgaactc 2734201 tcgataatca accggttccc cgtatacggt cacctcctgc gtatcaggat caacgtgctc 2734261 ctttacatct ttggcaggtt tgccgtcgat catcacggct ccagccttca caacggcttt 2734321 gacttctttt ctggaaccat acccgctgtt ggcaagcagc ttatcaagtc tcattcccaa 2734381 tctctccttt ataaaagaaa gcccgcagca tgcgagccct cagtttcatc atatctagtt 2734441 catcagcctg catgtctgcc tttcctaaag aaacctggca aacggcggcc taaaattttc 2734501 tgcaaaaatc ctaatcggta gccgcaatac aggtagacag ctccgccaac agcggccgcg 2734561 atcaccacaa caatcgcagc ttgcatctgg ccatcctgat aggaaataaa gaagcctaat 2734621 acccactgca cgattttcac ggcaataccc ataatggctg ataagaccag catcaaaaca 2734681 gttcgtttaa caagtatctt atacgaatag cctgcatggc gcttaatcat gataaaccca 2734741 tataaaaggg aagcgatata tccaagcgcc gtcgctaaaa tcgctccgtc agcctgcatc 2734801 agcttgatca gcggaacatt cagcacaagc ttgatcacga caccgatcac aaggctgaca 2734861 accgcaaatt tttgcttatt gatgccctgc agaatagctg cgttgactgt aaacaaagag 2734921 aacagaattg cgacaggcga ataccaaagc aaaatgtttg cccccagttc aggatgaagg 2734981 ctctctgacc cgtaaaagaa cgtatacgtc ggtcctgaca atagagagat cccgacaaca 2735041 gccggaataa ttaaaaacag gatcgtctgc atcgtttgat taatctgctg atttaacagc 2735101 ttatagtttc cgcttgtaaa cgattcagta atcgttggaa ttaatgtcag tccaaaagca 2735161 gttgctaggg aaaccgggat catcacgagc ttctgaacat acagggttag aatcgcaagc 2735221 atgtcctggc tgatggcttg atgaccggct tcaatcatcg ctttgttaaa cgtatttgta 2735281 tcaatatagt tatacaaagg gatggctagt ccgacaaaaa cgtacggagc agcatagctg 2735341 aacagctcga aaaacatttt cttgtagctt aggtttgctg tcggacccgt attcggcatc 2735401 atcgccagca ggctgccctt ccgtttgttc caataaatat aaagcacgac cagccctccg 2735461 aaggcaccga tcagcgctgc gaaggttgca tagcccacag cgatgacaag gccgccgttg 2735521 aaaaccttca aaatcaagaa tgtcgcactc aatagaaaga tgatgcggac aatctgttca 2735581 acgacttggg aaacagctgt cggacccatc atttggtgcc cttgaaagaa tccgcggaca 2735641 aggctcataa tcggtacgac caaaagcgct aagctgacca tgcggatgac ataaacgaca 2735701 tgatcaattg tcaggccgtt attatccttg cctcccagcg atatttccgc aaacatcgga 2735761 gccgatagat acagaatgaa aaaggctatc attcctgtga ctagcataac cgacatgccc 2735821 gccttgagca ttttcctgct tgtctcataa tccccttttg aattatattt ggaaacaaat 2735881 ttagaaacag cggccggaaa gcccatcgta gcaatattca aaaataaagt gtattggttg 2735941 tatccgtatt gaaataatgc accgcctgtc gccccgacca taatgctgaa gggaattaaa 2736001 tagaccatcc ccagaatccg cgatatatat gtaccgagcg ttaatacaaa cgtgcctctt 2736061 aacagtttgc ttgacatgtt tcttcatcac cattttctac gaagattcaa cttttctatt 2736121 ttaccacaac tgggcattta gacggtaata aatacaaaag caatcctgtg aacattcatg 2736181 tccgcggcaa aagacgttta aggagcggct ttctttcgct ataatagtac tgcggacggg 2736241 tgtccgcaca cgaaatgaaa agaaagttga tgataaagat gaaacaatat gacgtaatcg 2736301 taatcggcgg aggcccttca ggcttgatgg ctgcgattgc agcaggagaa cagggcgctg 2736361 gcgtgttgct gatagataaa ggaaataaat taggacggaa actcgcgatt tccgggggcg 2736421 gccgctgcaa tgtgacgaac cgccttcctg tggaagaaat tatcaagcac atccccggca 2736481 acgggcgttt tttatacagc gcgttttctg aatttaataa tgaggacatt atcaagtttt 2736541 ttgaaaacct cggcattcaa ttgaaggaag aggatcacgg ccggatgttt cctgtgaccg 2736601 acaaagccca aagtgtcgtt gacgcgctgt taaacaggct aaagcagctc cgcgtaacaa 2736661 tcagaacgaa cgagaaaatt aaatctgttt tatatgaaga tggacaggca gcagggattg 2736721 tgacgaataa tggcgaaatg atccatagcc aggcagtcat tattgctgtc ggcggtaaaa 2736781 gcgtgcctca taccggaagc acgggagacg gctatgaatg ggctgaagcc gcgggccata 2736841 ccataacaga gctgtttccg acagaggttc ccgtcacttc tggcgaaccg ttcattaagc 2736901 aaaaaacact tcagggctta tcactaagag atgtagccgt cagtgtgtta aataaaaaag 2736961 gcaaaccgat tatcacacat aaaatggaca tgctgtttac ccatttcggc ctctcaggac 2737021 ctgccattct cagatgcagc caatttgtcg taaaagagct gaaaaaacag cctcaagtgc 2737081 cgatcagaat cgacttgtat ccggatatca atgaagaaac gcttttccaa aagatgtata 2737141 aagaactgaa ggaagcaccg aaaaaaacca ttaaaaacgt gctgaagcct tggatgcagg 2737201 agcgctatct cctattcctg ctcgaaaaaa acggcatctc tccgaacgta tcgttttctg 2737261 agctgccgaa ggatcctttc agacaatttg taagggactg caagcagttt actgtcctcg 2737321 caaatggcac actgtcgctt gataaggcat ttgtcacggg aggcggggta tctgtaaaag 2737381 aaattgaccc gaaaaagatg gcttctaaaa aaatggaggg gctttatttt tgcggtgaaa 2737441 ttctggatat ccacggctac acaggcggat acaatattac ctccgccctt gtcacaggca 2737501 ggcttgcagg gctaaatgcc gggcaatacg cccgttctta atcattactc tttaaatctc 2737561 ttgccgccaa actcacattt gaacattccc cgcattcatg ttagggtgag acttgttttg 2737621 tttcacctga ttgcggggta attttaagag aggaatgagc tgccatcgta cgaccatact 2737681 aagcctgcga gcaagatata ggcgtacaca aaaaattaga gggtgagaaa tgttgaaaca 2737741 tatatctagt gtattttgga ttgtgattgc aatcacagct gcagctgtat tatggggtgt 2737801 tatttctcct gacagcctgc aaaatgtgtc tcaatcggca caagcattta ttaccgattc 2737861 atttggttgg tattatcttt tagttgtctc tttgtttgtc gggttttgtc tctttttgat 2737921 tttcagcccg atcggaaaaa tcaaactcgg aaagcctgat gaaaaaccgg aattcgggtt 2737981 attatcatgg tttgccatgc tgttcagcgc aggcatggga atcggcttag tattctacgg 2738041 tgcggctgaa ccgatcagcc attacgcaat tagctctcca tcaggtgaaa cagaaacccc 2738101 ccaagccttc agagatgcac tccgctatac gtttttccac tggggtttgc acgcttgggc 2738161 catttatgcc attgtggcat tatgcattgc ctatttccaa ttccgcaaag gcgcacccgg 2738221 gttaatcagc agcacactgt caccgattct cggggataaa gtaaacggac cgatcggaaa 2738281 ggccattgac tgtattgcag ttttcgccac tgttgtcggg gtgtcaacaa gtcttggtct 2738341 tggcgcaacc caaattaacg gcggtttgaa ttacctgttc ggcattccga atgcgtttat 2738401 cgtccaattg gttttaatca ttattgtgac agtgctcttt ttactttctg cgtggagcgg 2738461 actcggaaaa ggaattaagt atttaagcaa cacaaacatg gtattggccg gattgttaat 2738521 gttgtttatg ctcgttgtcg ggcctacagt gctgataatg aactcattta cagattctat 2738581 cggacaatac attcaaaata tcgttcaaat gagcttcaga ctgacaccga acgatcctga 2738641 aaaacgcgaa tggattaaca gctggacgat tttctattgg gcatggtgga tttcctggtc 2738701 tccatttgtc ggcattttca tcgcccgtgt atccagaggc cggacgatcc gcgaattttt 2738761 aatcggcgtc ttggtgacac cttgtatttt gacatttcta tggttctcca ttttcggcgt 2738821 atcagccatg gatctccagc aaaaaggcgc gttcaatgta gcaaagctgt ccactgaaac 2738881 gatgctgttc ggaacacttg atcactatcc gctgacaatg gtgacatcga tccttgcatt 2738941 gattctgatc gcagtattct ttatcacgtc agctgattca gctacattcg tgctgggcat 2739001 gcagacgtcg tacggttctt taaatccggc gaattctgtg aaactcagct ggggtatcat 2739061 tcagtccgcc atggcggctg tgctcctata ttccggaggg cttgccgctt tgcagaacac 2739121 agcgattctg gcagcgctgc cgttttctat cgttatcctg ctgatgattg cctctctcta 2739181 tcaatcgctc tcaaaagaaa gaagagagat caaaaaagcg gagaaactcg ataaaccaag 2739241 aagtccaaga gtgaaaaaag catattaaca aaaaagatct ttccgcgcct gcggaaagat 2739301 ctttttattt gcgatataaa ataagggcgg aaaaacagta aagctgctcg ccgtctgggt 2739361 cgcacgccgc cgaaaccgta tatttgatat ctatcagctg ctcctccgat atccctttta 2739421 aaaatgaatt gatttccgtt tgtaagtctt tttcatgctc ttcatcaaat accgctacct 2739481 tcagcatttt atccgctctc ctttctctat caatctattc cgtttggaac agcgttatga 2739541 tagagaaatg atgattatct cgtttccgga taaaaagctt tccgtatatg ggatttcctc 2739601 tgtggctcgc cgccgtgctg ctccactttc agcagcacgg cataaacaat gcgcatatgg 2739661 cagtagctga taaggctgac gctgaaaaaa gggacaatgc ccggcaggta cgcaagcaag 2739721 aaaaagagag caacagtcag cgcaagcata gtaagcgtat attgcaaata cgccacactg 2739781 agcaagagcg aaaatttcac atacagacgt tttttccagt caaaatggac aagcagcgga 2739841 aacacataaa aaagcatgga tacgaacaaa aagccaaata tcataatggc gaagcgcagg 2739901 atgtgcagaa ggaaatgact tggataaatt aaggccaaat caatataaat gatcactccg 2739961 atgagcgcca gtacagcgcc gagcagattt gaacgaaaaa attcaccctt gtattcctgc 2740021 caaaacgttt tgagcaccgg aacgttgtcc tgcccctgga tccacttccg catgacagcg 2740081 aataaagccg cggtcgcggg catgatgcca aacacgccga gaccgagcaa cgtaaaaaac 2740141 agccacagca agtttgtata cgcaaatctc ataatccatt cgcaaaaacg cagcatccgt 2740201 cccagtgagc catcatgttc catggcgccc cctccttttt tgcattatac attctgcatc 2740261 tgaaaaagct ctttcatgcc gatcggcttc ttttcggcaa ccgagcgcca cattccctca 2740321 ccaaccgcga tggagtaggc tccagcttca gccccggcta aaatatcata gcggcgcagc 2740381 gggtctttcc ctaaaaaaag atcctcaagc aaaagcggat cacctccgcc atgcccccct 2740441 tcatttttga ccacttgtat cgtctgcttt gattcaaaaa gcggatagta ttcgattgtc 2740501 tgctcaggaa aagcaaacgg aattctggaa ggttcgtgaa attcatttga ttcaatacgt 2740561 ccttttgtgc cgttgatcgt cagccggtag ccttcatacg gggccgaaaa aataatcgag 2740621 tagcttaaca gtgcgccgcc atcatatttg actgccgcca cgtacgtatc ctcgatgtca 2740681 atttcctcgt caaaaataca cgcgtcaggc ctgtatgcag tatataagct ggactggtct 2740741 cctgcttcaa gatgatcatc ctttatagaa gctttagagg aacggggatg ccaccttgaa 2740801 tagtagtggc atttttcttt aacacggcac gtcccgcaaa aacgcccgtc ttcttccggc 2740861 aaggggttcc actcactgtc cggcccatag taattcaagg cgccataagc aaatacctct 2740921 tccggatttt gcccgagcca ccaattgacg agatcgaagt gatgtgttga tttatggaca 2740981 gaaagaccgc cggaaaactg tctcgacctg ttccagcgtt taaaatagct ggcgccatga 2741041 tacgtatcaa tataccaatt taaatcaaca gaagtgaccc tgcctatttt tccgtccaga 2741101 atcatttctt ttattttccg atgaaacggg ctgtagcgat agttaaacgc gacggtgact 2741161 tttccttcgc ttttggcctc cgcttcaagc acccgattcg catcctgcac tgttgtcacc 2741221 attggttttt cagtaatcac atctgtattc cactgaaggc tttttacaat atatgcgaca 2741281 tgcgtatcgt ccctgcctgc cacaatgacg atatcaggct ttgagacgcg catcatctcg 2741341 tcaaaagcat cttcgctaaa ctcaggcacg tgggccagct cgggaaattt cttcttgcaa 2741401 acggcaaaac gtttcggatc ggcatccagc aatcccgtaa tctcataatg agttgaaaac 2741461 cgctccatca gtggtttgat aaacatactg aatgctctgc tgctcaatcc gcaaaagacg 2741521 atgttcttca atatcctcac ctctatcggg cttcagttag ttgagaaatc agctgcagcg 2741581 cttcctctgt tttttcagca tacacaggga taaacgccgc catatcgcga ttcaattgaa 2741641 aagaatagcc gttcagctgt tttttccctt tttcgatctg aacggcatag atcgtttttt 2741701 ctcctgtttt tttattaaca gttgtataag gagatgtttt ttcaggaggc aatccgttta 2741761 acggctgaaa attttccgga tcatcgtaag cttgaaacat gtcttcaggc acgatgaaaa 2741821 catctccctc atgggcggta atttcagtca gcagtttttc ctgaaaagct ggaaagatat 2741881 cgaccttccc ggcattctgc tcggcggcct tttttatttt ttcctgtacg ccagcctgca 2741941 tatcagaaaa gagaatgaca tgcattccgt ccggcctgct tgagcatgat gccaaaaaga 2742001 gcactgagac gatcacacac aaagccgtac gtatcctttt tgtcatttcc ccgctgacct 2742061 aaaaagaggc tccagctctg tcatagctaa aataaacgcg ccggctccgt gcagatcgtt 2742121 tgtgcttctt tcgcggctga cataatagtc atagaaaccg gctgacgttc cgacacatat 2742181 gtctttgacg agaaacgctc cgtcttctga tgtttcggtt ttatgctgaa tcaagccttg 2742241 atacgctttt agcagtgttg tttcgtaagc tctgtctaga tagcctttat tgattccttt 2742301 tgcgattgcg tacatgtaca gacaggatcc tgagctttcc agccagttat cagacctgtc 2742361 tcccttatca acgatctggt accataaccc cgtctctttg tcttgatagc gacagatgct 2742421 tttaatcatg tcctgcagcg tgtttttcca cacatgacgg ttcggatgct tcttcggcag 2742481 ctcttcaatc atgtcagcaa gagacatgac gtaccagccg atggaacgtg cccaaaattc 2742541 cggtgaacag cctgtctctt cattggccca aggcattttt ttcgcttcat cccaggcgtg 2742601 ataaaaaagt ccggtttttg catccttcgt atgctttctc atcaatgact cctgaagcac 2742661 aacctgatca aacagctccg tctcctgctt cagattggca tatttcagtg caaacggccc 2742721 ccccatgtat aagccgtcaa gccacatttg gtaaggataa ccgtctttgt gccaaaaacc 2742781 gccctcagac gtccggttca gtgttccata taagctgcgc agcctttttg ccgctttgac 2742841 ataccgttca tccttcgtct gctcgtataa tggaaaaaga atgagacctg cttgaatggc 2742901 gtccagttca tctcttctaa ataatagatt gccattatca tcgattaaga gatctgcata 2742961 agccttcgca tactcaaaat accgcttttc cccggttgct tcccacagcc gcaatacacc 2743021 gcataagaaa acaccctgat ggtagtgcca gcggtttgca ggtggcagct cctcgactgt 2743081 gtacgtgttc ataatggtgt ttgccaatgc ctccgcgtac gtaagaggcg attttacagc 2743141 gattgattga tccattgatc ccatcccttt cctaataaat tccttcctcg ccaaatttct 2743201 tcgccaaacg attcgctagc atgaccaaaa tcagcccgac cgccgcttta aatacgccga 2743261 ctgctgtact gtagctgaat tggccctgtt tcagccctgc agtataaaca tacgtatcaa 2743321 aaatttccgc cacttccctg ttagtcgcat ttaacagcaa atacacatgc tcgaagccaa 2743381 gctccagcgt gtctccgatt ttcaaaatca gcaaaacgac gataacgctt ttaatggcgg 2743441 gcagcgtaat atgccacatt tgccgcagcc gtcccgctcc gtccattttc gccgcttcat 2743501 acagctgggg gtcaaccgct gtaatggccg ccagataaat gatcgtcgac cagcccgctt 2743561 ccctccagat aacctgcaga atatacaggg gccggaacca ttcttcgttc agcagaaaat 2743621 tgattttttc accgccaaaa aacacaatca gttcattaat caagcctccg tctaccgtta 2743681 aaagcacaaa cgaaagcgat acaacaatga cccaagacat aaaatgcggg atataaatca 2743741 gcgtctgaac aaatttttta aagagagcaa tccgcacttc gttcaataga agcgccagca 2743801 gtatcggcac cgggaaaaat atggccaggt tcaaagcaaa taacacgagc gtgtttttta 2743861 acaagagaaa aaatgtaggc tcagtaaaca gcctgataaa atgcttcagc cccacccact 2743921 cactgcccaa aatgccgagg aacggctgat aatcctgaaa cgcaatcaca attccccaca 2743981 tcgggacata cttaaaaagc aaaaaataaa tacaccccgg caaaatcatc aagtacaaat 2744041 atttttgttg aatcagcttg attagtaagc gctttctttt ttctttttta aaaatgactg 2744101 catcaacagc cggcgcttgc gcttctgctg ttttcatttt ttcctagcct cctttcacgg 2744161 attcttgcat tcactgtagc gcagcaggca aaagtccgtc tacaatcata tgatcacatc 2744221 ctgttttatc cctttataat caagggttca gccggtccac ctgaaaaaaa gacaccgata 2744281 ttagaaaatg attattgaca atatctatca atctttggat taattgtatt aaggtgaagt 2744341 ggatgttatg aaatgggggg ttttatgaaa agaagccaat acaagtttta ctacaaactg 2744401 atcacgtttt tctgcctgct cagcaccatt ccggttattt tggtcggatt attttcgtac 2744461 gagcactctc agaaaacggc tatttccaac gtttcggagg aaaaattcga cacactccag 2744521 cagacccagc aaagcatcga gcatatattg aaaaccgtcg atcactcttt aacccactat 2744581 gtgagttcgc cgcctctcct tcgcacattg tccgagcctt tgcactcaga ccaatttcaa 2744641 atctataacc aagtgaacca agagctcaat tatctgcaaa gctttgatac cgatctgtcc 2744701 aacatgacgt tagtcagtta tacgaaaaaa tggtacatga acaattccgg tttgtaccgt 2744761 ttgaatacag acactcttca tgaagcagcc tcagcgtaca cgaaacaaaa agcgagccgc 2744821 tcctattgga cgcttgagga aaacaatcat ttgatttcaa ccaaagaagg cacagcagaa 2744881 aactgccgct acaatatcaa tttaattaag cagcttcctt tgaacagcac aaatacaaag 2744941 ggattggccg ccgcaagcat cccgagctgt tcgcttgtca aaaatatgcc cggctattca 2745001 aacgccaaca acctgtttat catcgatgaa aaaggcctca tcatccttca taacaatatg 2745061 tctgacgttg gtgaatctct tcataacgac ggctttgtcc aaaaagtgct ggcgcaaacg 2745121 gccaatagcg gacagtttga aacagtgatt gaccggattc attataaagt cacctatcaa 2745181 aaatctgact ataatgcatg gacttatttt tctctcgttt ccctgcctga gttaaaaaaa 2745241 gaagccaaat caatcggctg gatcactttt gcagtatgcc tcattttgtt aacgctttca 2745301 ttgctgttct cttggcttgg ctcccgccat ttttacaagc cgatcagggt gctttacgaa 2745361 tcattcgcaa gacatggagc catacaagag aaacaacagc ctcctcaaaa tgaatttgag 2745421 ttaattgaac agagctttaa gcagctgaag gacagaaatg acgaccttga agaaacgatg 2745481 aagcagcagg ccactcatct gcagcaatat tttatggtca ggcttatgct tggaaaactg 2745541 acggatgagg aggttgataa ccgttttgaa agcctcggct taaagcaaaa ttggcggcac 2745601 cttgccctgc ttgtgctcca aattgacaca ctgaatcata cgccttatga gaaaaaagat 2745661 atggatctgc ttttgtttgc cgtcaacagc ctgattgagc gcaacatccc gacggacaaa 2745721 catcttgccc ccgccgtagt tgacaaacag caggcgacga ttttgatcaa tcaaagcggg 2745781 acaaaggaag aattcatggc tgagctgaat gagactgcaa ggatgattca ggaaaaagcg 2745841 gaagctgagc tgcagctgtc tgtcagcatc ggcatcagcc agccgtttga tgtgctgaca 2745901 aaagcgaaaa cagcctatgc ggaaggctca gaagcgttga aatatcggct gaaagcggaa 2745961 aacaagtcga tcatctttta cgaagacctt gaccagaaaa aaaccttcaa aacccatttt 2746021 ccaaagcagc ttcagcatga gctgttcgat gctgtcaaag caggagacaa ggagaaagcg 2746081 gataaatgcc tgcacgcgat tttacaagcc attttcaccc agaacaccaa cccgtatcaa 2746141 tttcaaatcg ccatcgcccg ttttttgaac catgtgattg agctgatgca tgtgcttggg 2746201 atcgaattgt ttgagcttga agaaaacaaa atgctgtatg accaaatttt tgagctgaaa 2746261 acgttcgagg ataccgaaaa ctggctaaag aatgagttta ttgatccgat gacagacaaa 2746321 gtgaacgccc gcgcggatgc ccagtacaaa aatatttccg acaacatcat tcatatcatc 2746381 catcatgagt ttgaatccga attgacactg gacgaaatcg cacgcaggct gcattacaac 2746441 ccaaattatt taagcagtat tttcaaaaaa gaaatgggaa tttcattcag cgagtatgtc 2746501 tcaagctacc gacaccatat ggcgaaaagc tggcttgccg aaaccgacat ggcggtcaag 2746561 gacattgccg aaaagctgaa atataaaaac tcccaaaact tcatcagatc atttaagaag 2746621 ctggaaggga ttacaccggg aaactaccgc cagcaaaaaa gaagcatgta aaaaacccaa 2746681 aaccgcttgc gcgttttggg tttttccaat gttattttgc ttgtttaaac gcttcttcgt 2746741 attcctgaat aatttgtttt cctccgcttg actcccattt ttccacttct ttatcgaact 2746801 ggctttctgt gatgtctcca atcatatatt tgtaggtcgc gtcatcaatg attttcttca 2746861 gttcgtcacc ccgttccgac tccgatgcgg aatacaggct ttcagccggg tttgagacga 2746921 taatcttttc attgtcctcg gtcagctcct cgtacgccgt ccgaagcgga tctccagtgt 2746981 tttttaagta ggctttatca atggcaatta aagcggacag cggctgaata tcagtctgcc 2747041 agtcttttac ctggctttct ttgcgtgtaa acgttttgtc ctcacctttg ttgtaatgaa 2747101 cgccgtcaat gccataagtc atcaggctat agacatcttc ttcggcaatt cggtcaaaaa 2747161 acgccaagat ccgtttaagc tcagcttccg ttttcacact cgttttcggg aaagcaaaca 2747221 cgccgttatg gcctcctgat gcccataccc gctctttccc atctgggcct tttatgcggt 2747281 tgatgatctc gagcttcatc gatttatcag aggcatggtc gcgcagattg accgcatcta 2747341 ccatattgcc aatataaatt ccggcttttc cttgagaaaa cagctcttgc tgctgggttt 2747401 tgcttgtgac gggaaaatcc ttattcatat acccgttatc acgcagcttt ttcatatagt 2747461 tcatcgtgtc tttgtattcc tgtgtcatga aatcaggcgt gaatttgccg cccgattcct 2747521 tccaatctgt cggcatgcct tcatacgagc caatcgtttt aaacgcgccg taaatcaagt 2747581 cattacggtc tgccagcccg aatgtatcat ctttcccatc cttgtccggg tcgtcctccg 2747641 taaatgcttt ggccacttca taaagctcat ccaacgtttt cggggttttc aaatttaaat 2747701 tgtccagcca gtccttccga atgacgatcc cctgtctgga aagcgggcgc tctctgtata 2747761 tcccgtagag cttgccgtca attgtcacat ttttattaat gagtttgttc attttgttta 2747821 agttgggata atccttgata taatcgccga tttcccaaaa cattcctgac cgaaaggcat 2747881 tcatgactga cgaattttta atatcctgga tggtcacgat ttgcggaaga ttgccggctg 2747941 caagcgctgc attcagcctg tcttctttca ccgcgtctgg aacccaggtg atgtcgagtt 2748001 ctgtatttgt cagcttttca atttctttaa tcgccctgtc tttcggcggc tgctggtgat 2748061 acaaaatcgc catccaagac agctttacct ttgaatctgg gccagctttg ccttcagccg 2748121 aagactgatc agttccttta cagcccgcca gcactccgcc gagtgccagt acaagcacaa 2748181 tcaaaagcac cctccatttg tttcccatcg tacccctccg tttcatattt ctttatcctt 2748241 tgacagatcc cagcaaagct ccttttgcaa aatgcttttg tataaacgga tagacaagca 2748301 gaacagggat ggtcgccacc actatgaccg ccattttaat ggtttgctca ggcggcgggc 2748361 tgcccgaccc catttcagac atatccccct gcataccgct tgatacaatg acgatttggc 2748421 gcagaagcac ctgaattggc cattttgctg aatcatttaa gtacaagatc gctgtcatat 2748481 acgtgttcca atacgtgacc gcataaaata gtgaaatcgt tgcgatcgca ggaagagaca 2748541 gcggcagcac aattttaaag aatatgccca gatcattgca cccgtcaatt ttcgcggact 2748601 cttccaggct tgacgggata ttttgaaaga agtttttcag aatgatcagg ttaaaggcat 2748661 taatggctgt cggcaaaata agcgcccagt aagaatcgag caatccaagc gatttgacca 2748721 caaggaaagt cggaatcatg ccgccgctaa acagcatcgt aaatacgacg agaaacatga 2748781 gcggctgccg gccgattaaa tcacggcggg ataacccgta agccatcagt gacgaaagaa 2748841 acatgctgac cgcagtgcct atcactgtca caaacacaga aacaagcaaa ctcttataaa 2748901 taatatctgt tgaaaaaatg tagcgataag catctagcga aaaagtggtc ggtattaaaa 2748961 taaatttttt cgacacgact tcttctactg tggcaaagga tgctgcgata acatgaatga 2749021 acggaagtac gcatattaaa gcgaacatca gcaagaaacc ataaatcaac atatcaaaca 2749081 gacggttttt cagtgaatgt gcgatagctc ccacctccct ttgtaagcgt tatcatattt 2749141 ttggaaaccg agctcagcat gtgacgatat cgtgtctaaa atgtagcaaa tctgtgattg 2749201 ccatgtctat aatcatttga acagtgtccc cggccgggcg ggggctgccg cgaattgaga 2749261 ccgataacaa aagaaaaaga gcataatctt agaaaatgat tatgctccgt tctcctcctc 2749321 gttcagaagt tcagccgtat tgatttgtgg cgaaaaccca agttcattca cggcagattc 2749381 aatggaccat ggccggcccg gattatcaga gacggcgtaa taagtgccat accggatgtt 2749441 ggtctcaatg gcggctttga aaatcgacag cagatcgggg tgagaaagca gtgtcttttt 2749501 cgtccgttct ttttcatgca gcgtatccat ttcatctgtc acgactgttc cgattcgaag 2749561 gttgattact gatagcttat tttccaaata aaacaaatgg ccgatctgtt cagaggtcag 2749621 ctttaataca ccgtacaagt tttttgacag cggataatcg cttgttgtga tttcccgtcc 2749681 taagagcgag cgcccgtctt tttcatatac atctgtgaca tgattgctgc tggcgaacac 2749741 gagcttttga atgccgagct ccgctgccgc acggcacaga taatagcttg ccctatagaa 2749801 aacatccgtc attttttcaa actcagcgat gtccataata tcgtatttga ttttcacagc 2749861 gagtaaattc aagatggcat cggtatcttt tggaatcttc ttcaacagct cctcataatt 2749921 tgccgcgtca gcctgaatgg aagaggcttt gccatcgaaa tgatctttat caagcacagt 2749981 cacttcatag tctgaaataa gcccttcagc aagcagtctc ccaatcacac catttccgcc 2750041 ggcgatcagc acttttttca cgatgttcac tccccttttt tatagattgc ccattttcgg 2750101 cggggctgac acttttttgg cactcacatt cttaggctta ttcaaaagtc accggcagct 2750161 cctcaagcgc ccgaaatcca aaaagcggcc gataccgcca ttcaaaatcc gcaagattaa 2750221 ggctgggcat tcgctgcaga agagtgttaa tcgcaatttg cgcttctaat cgtgccagcg 2750281 aggaccctaa gcaaacatga tggccatgcc cgaatgaaag atgcggatta ggacttctcg 2750341 taatatcgaa gacatcgggg ttcgtgaata tgctagggtc tcgattagcc gctcctaaca 2750401 aaagatagac ttgttctcct tgacggatcg tcaccccgca gatgtcaata tcctctgacg 2750461 caactctggc tgtcatttgc gtggggcttt catagcgtaa acattcctcg actgcggtac 2750521 caataagatc tggattttct ctcagtttca aaagctgttc tggatgctgc agcagacaaa 2750581 ggactgaatt gctgatgaga ttgaccgttg tctcatgtcc ggcgatcgcc agcaatatgc 2750641 acgtagatgc cgcctcctct tccgtcagct tatccttttc tctccccttc aagagcatgc 2750701 tgatcatatc ctgttgaggg tggcgttttc tcttttgaat cagctctttg aaatatgcca 2750761 tagcctgcac agccataata ttgccctctg ttaatgcctt tcttgagcgg gtaaaatcaa 2750821 tcgtttgaat gagactcgca gcccactcct ttaattgctc cctatcttcc tccggtacac 2750881 ctataatgtt agctatgaca aaacttgcta aaggaaaagc aaagtccgaa atgacctcca 2750941 tctttttttt accttgcact tgatcaagca aatgatggac agtttcaatg atatacggct 2751001 gataactctc tgtcgttctc ggcgtaaacg ctccgctggc aagcgtccgc aatcgtctat 2751061 gatcaggctg gttctgaaac agcatcattt gattttgcac atgtgaaagg tcctgatatt 2751121 tggttgagct ctcaggcagc ggggtgcgga ctttgaatct cgcatctttc aaaatagcag 2751181 ccgtttcttc atatcctgtg acataccagc ccgggtattt taagaaactc cctttataga 2751241 taggatgaac agctcgcaat gtgtcgtaaa aagaatatgg gtttttcaaa aactcagaag 2751301 atgcagttga cgatgcaatt gtcacgtgat tttctccttt ctgttcaaaa ataaaaacaa 2751361 tcgacatcat accgattgct tttattgatt ctttcagctt ttcgcactta aactagcctt 2751421 catttcttcg actgattcaa cttcaaagcc taaatcactc agcattttat gatcctccgt 2751481 ctcctcttgc ccggcagttg ttaagtagtc tccgacaaaa atggagtttg cggcgtaaag 2751541 ccctaatggc tgcaatgtgc ggagattgac ctctcttcct ccggaaatgc gaatttcttt 2751601 tgatggattg ataaaacgga acagcgccag cacttttaaa caatacagcg ggtttaattc 2751661 gttgacgcct tctaacggcg tgccatcaat tgcatgcaaa aaattcacag gaatggaatc 2751721 cgcgtcaaga gccttcaagc ttttggcgat gtcaatgaca tcctgtttcg tctccttcat 2751781 cccgataatg gcgcctgaac acggagacag ccccgattct tttgcgattt caaccgtatt 2751841 gactctgtca tcgtatgtat gtgaggttgt gatgtttgaa tggtttctct gtgacgtatt 2751901 caaattatga ttatagcggt ctactcctgc atctttgagc cgcttcgcct gctctggctt 2751961 caacagtcca agacatgcac aaatcttcag tccatacgtc tctttaattt cctgaaccgc 2752021 atctacgacc tgatccactt ctctgttaga cggacctctg ccgcttgcca cgatacaata 2752081 tgtgccgata ttcagatcgt gcgcccgctt cgcgccttca agcagcgttt ccttattcac 2752141 catccggtaa gactcaatcg gcgctttcga aatcgcagac tgtgaacaat agccgcagtt 2752201 ttccgggcag agcccggatt tcgcattcat aatcatattg agctttactt tttttccgta 2752261 aaagtgtttt ctgatgtgaa aagccccgtg cattaatagc aaaatatctt catcaggaca 2752321 atgtaatatt gaaagcgcct cttcgtcagt cacttctgct ccagccagca cccggtctgc 2752381 gagttccatc cattgattca ttctcatacc cccacttgat tcatcagtaa tgatagattg 2752441 atatggtctt ttaccatatg tagaaccgtt tctttcgtca cgttggcaag ctttggcgta 2752501 acccctaaaa tcggcacacc gcataagcgc tcaatcatct caggattggt tttttcatct 2752561 tcatcaggag agtcactgat tccattgatg ataattccgg cgattggaag ccccatgctt 2752621 tctgcatatt tgacagttaa aaaggtatga ttaatggttc caaggcgagg acgcgccaca 2752681 ataatcatgg gaagctgcaa cgcttttatg acatgactga ccaaatagtc ctctcccaat 2752741 ggcacagaaa taccgcctgc accttctacg atgaagcatt catgtttttc tctaatccgc 2752801 ccccaatggc ttaaaacctc ttccatggtg acagtctttc cctcaagttt ccctgcaacg 2752861 tatggtgcaa gcggcgcctt gaaggcaaaa ggcgtaatgt cttcatgaga aagactggtc 2752921 tgcgacatat ctttcagcaa acttgtatca ctatctggat gatggcgcga tatcccgctt 2752981 aaaaatggtt tatacacccc gacatgtcta ttattgtctt tcaataaggc agcaagaccg 2753041 ctggatataa ccgttttccc tacttctgta tcagttcccg tcacaaaaaa acccctcaaa 2753101 tgatgtgcag ctcctttccg attgaatgaa atgtttgcag caaatgatca atatcaccca 2753161 tactgtggtc agacgtgatt gtaattcgaa tccggctttc acccggcgca acggttggcg 2753221 gccgaatggc aggagcataa attcccttgc cctgcagttt ttcagcaaat aggaccgttt 2753281 tatgggcatc gccaatgact acaggaataa tcggtgtgtg atctcctttc accacataac 2753341 ccatattctt cagactggtt ctgatcatgc tgatataaga aaataaaagc tgtcgttttt 2753401 ccctgctggc ttcaatgatg ttgaaagcct cgtgagcagc cgcacagctg gctggcggaa 2753461 tagcggtttg aaagataaat gttctggcat ggttcagcaa aaagtcgatg aagaccgctg 2753521 atcctgccgc aaaacctcct tccgcgccaa cagctttgct taaggtgccg ataacaatgt 2753581 cgggacaaac accaaagtat tcactcgttc cttgtcccga atcgcccaaa actcctgttg 2753641 cgtgggcatc atcaacgacc acgaaggcat gatagcgttt cgcaagtgag atgatctgat 2753701 caagaggggc gattgtgcca tccatgctga atactccgtc tgttacgata aaacggcgct 2753761 gataacgctg tgtttcattc agcttgtttt caagatcatt catatcaata tgccgataaa 2753821 caactgtatc agccttagaa agtcggcagc cgtcgatcat acttgcatga ttgagctggt 2753881 cacttaaaat gacatcttcc ttttctggca aggatgaaag gacaccgaca ttggccaagt 2753941 aaccgctcga aaacagcagg gccgcttctg tcagtttaaa gctggcaatc ttcttttcta 2754001 gcttttcatg ccagaccgaa ttgcctgtcg ttaaacgtga accgctgctt cctgtcccaa 2754061 attgctgcaa tgctgtttgg gctgcatcga tcaaacgtct atcgcttgcg agccctaaat 2754121 aattgtttga ggaccagacc gtttgatttt cgccatcaat attcctctct ggaaccggcg 2754181 ctccatccat tgaccgcagg ttacgatgta cgccggcttc tttcattctg tctaaccgct 2754241 cgtttaacca ggaatcaatc ttcaaggctc gtaacctcgt ggatcgcttg tttcataatg 2754301 gcaaccattt ccgagagctc ttcagctgtg ctggcaagag gaggaagaaa tgcaatcacg 2754361 tccccaagcg gtcttgtcag cattcctaac tctctcattt ttaaggaaac tttgtatcca 2754421 atccgccgat cagccgggta aggttcttta gtttcctttg atcgtacaag ctctgcaccg 2754481 cacataaagc caagctgccg aatatcccca acatgaggaa gagcgtgcag atcttgaaga 2754541 agaaaatgga gctttttact tttttccgct acttgttcca caatgttttc agattcaaat 2754601 aatgccagat tttcaagcgc aaccgcacag ccaagctgat tgcctgtata ggaatggcca 2754661 tggaaaaagg tttttaggtt ttcataatca tcatagaatg ccttatagat gtcttcagtg 2754721 gcaaacgtaa cggcaattgg caaatagcct cctgtaatgc ctttaccggc agccatcaga 2754781 tcaggctgga cattctcgtg ctcgcacgca aacatttttc ctgtacggcc aaagcctgta 2754841 gcgacttcat caacgatcat taagacatcg tatgttgtac atagctcgcg cacgcctgcc 2754901 aaatatcctt ccggcatcac gatcataccg gacgcgcctt gtaccattga ttcaatggaa 2754961 agcgcggcaa tttcctcatg atgttcctca agcagctgtg caagctctcg gaggcactga 2755021 tcacggcact catcaggatc accgctttca gaacgataca cataaggaat cggggccttg 2755081 taactctcga acatcaacgg gccgtatacg tggtgaaaaa gctcaattga accgacactg 2755141 acggcgccaa tcgtatcacc gtgatacccg tttttcattg cgatgaattt ttgtttctcg 2755201 ggcttcccga tgttcttcca atactgaaac gccattttta gggctatttc catcgcctct 2755261 gcgccgctgt ctgaataaaa gacccgcgtg agcttttttg ggctgatgtc gattaatgtt 2755321 tcggcaagct gggttgctgg aacattggtc atgcccaata acgtggagtg cgcaattttt 2755381 ccgagctgtt tttttatggc gtcatctagt tcttttttgc ggtgtccgtg gacattaagc 2755441 caaaccgatg aaaaaccgtc atagtattcc ttgccgttta tgtctttgac tttgattcca 2755501 gtcccgcttt cgatgattaa ggggttttca tcataatctt tcatttgggt aaatggcagc 2755561 cagaggtgct ttttactttt ttctatcaaa tcatgagtca tgatcttcct cccactctat 2755621 taaaataggc tgcttctcca ggtcatgtat gtacgtgttt acatcattgg atccatcaat 2755681 aaaaaagact cggcagccct cttcagtccc gtattctttc attgctgtaa tacgctgata 2755741 gcccattttc ttacccgcaa catagcctgt tatgtaatcc ggatcgtccg accagcataa 2755801 ttctgcaacg actgccgggt gccggcttac ctttgaagcg agcgcaaggg cctcttttat 2755861 tcttgaatga gctggcacgt gactgtgaag cgcccatttt tcaaaattag cgtccggcca 2755921 atccattctg gagacccgca cccctttttc ttttgtttga tccattcgct tgcctgtatg 2755981 aatatcaaac aacaccgcac ccctgacatc tgaccattca gggatttgtt catatgcttt 2756041 ttcaatcacg tctcgtgaaa cgccttcttt ttccaataac aatcgggcaa gcttttgtcc 2756101 ttcttccggg cagctcactt cattcgtatg cacaggcaat ggctgaatgg tttttatcga 2756161 ttcatgtacc tcttcaaatt gaatttgcat aaaatcaggt tttcctcttg aatgggataa 2756221 ccctttttct aataaagcat tgactgtatg cttcatctca tggaaaggaa taagccgttc 2756281 tccgccggat atatgctttc cgccgtcttc atgagatcca ttcattgaag ccctcattct 2756341 gacactataa aaagtttctt cttgcatcat ttctcgccct ttcactgata actgaagaac 2756401 gtgtagcgct tctcacctaa attgttaacc aattatattc aaaggttaac aattagaata 2756461 tattattctc tcctgtttct gtcaatagaa gaaaggatcg atttatggca gttggttaaa 2756521 aggaaacaaa aagaccgttt tcacacaaaa cggtcttttt cgatttcttt ttacagtcac 2756581 agccactttt gcaaaaaccg gacagcttca tgccttataa ctgctgtttc gaaatgtccc 2756641 gaagcagaac ggaccactcg gtagcaatca gcagctccct gtccagcata gacagctgtc 2756701 aattcttttt cgattttgtc cacgccctca gccggcgtta accgatcgtg tacaccaaca 2756761 agactaaggt gcgggcgcgg cgcgatcagg ctttggatct ccgatgcgga aaaatgcttt 2756821 gcaagcgatg ggacgtaata ataaaagccg tgcctgtcaa gattctgtgt tttgatcagc 2756881 acgtgatgat ccacctggct gcacaaatcc acacacacct taatccggtc atcgagcgcc 2756941 gctgtccacc acgccatcaa acctcccata gacatgccga tggttccgat cctgtcaggc 2757001 tgaacatcag agcgtgactg catatagtct aacgcactta aactgtcata aatcatcatc 2757061 ccccacatca cttttccggt gagaagcatt tctttaaata tctcgctttc cgcttttccc 2757121 cgccgatctc caaaccccca atgatcaatc gcaagaacgc cgtatccgag tgaagtaagc 2757181 tcatcagaaa aagaaggcgt tttcaaataa tccgctccct caatcagctc actttttccc 2757241 ctatcatact ggcctccatg cgaatgctga aacaatacgg ctgggcacgg tccttctgtt 2757301 ttcttcggct tcacaaaata agcgggcgcc ttttcatgtc catttaaatc gagcaggagc 2757361 gtttcaacga tattttcttc tctttcttca atacgtaatg tctcaacact gattggcctc 2757421 cgatcaggca aatcaccaag caatcgaaac agttgctttc ttctttcggc tctcatccca 2757481 tcacccttcc ttattcgctt acttcacatt tacgagacag atctgggttc ccctttattt 2757541 ttccaacata aatcacatca tttactaaat atttagtaaa tattatggaa tatttcgaaa 2757601 acaattattg taaccgctta cttttatatg ataatatcaa tttatcaaaa acagatgagt 2757661 taatatttta ctaaatagat gagagggata cccatggttc gtattaaaga tatcgccttg 2757721 aaagctaaag tttccagcgc aactgtgtcc agaattttaa atgaagatga gtcgctttct 2757781 gttgcgggcg aaacgagaca aagagtcatc aacatcgctg aagagcttgg ttatcaaacc 2757841 gttgccaaac gccgaaaatc ccgcgggcaa aaacagcggg ctcagccgct gatcggtgtg 2757901 ctgagctgtc tgtcccctga tcaggaaagg caggaccctt atttttcttc cattcggaaa 2757961 gggattgaaa aggaatgctt tgaacaggaa attttcatta caaattcgat tcatctcggc 2758021 tcctttcagg aacatatctt tcgggaattg gatggtgtca ttgtcatcgg ccgtgttcat 2758081 gatgaagcgg ttaagcatat cagcgggagg ctggagcatg ccgtatttat caatcattca 2758141 ccagatccgc aagcatacga ttcgattggc atcgattttg aatcggcttc acgccaggcg 2758201 attgatcacc ttttcgactt aggctacaaa cggttaggct acattggcgg acaagaaaaa 2758261 gagcatacgc tgaaggacgg ccaaagcatt cgcagaacga ttgaagataa acgcctgacc 2758321 gcttttttgg agtcagccgc cccccagcct gagcatgtgc tgatcggaga atacagcatg 2758381 cgtgagggct atcgcctgat gaagaaagca atcgatcaag gccatctgcc ggaagcattc 2758441 tttattgcca gcgattctat ggcgatcggc gcattaaaag cgctgcagga agccggactg 2758501 caagtgccgc gggataccgc aatcgtcagc tttaacggca ttgaggaagc tgaatttgcc 2758561 agcacgcctt taacgacggt gaaggtatac acagaggaaa tgggccggac aggcgtaaaa 2758621 ctgctgcttg accgtctcaa tggccgaacg cttcctcaac atgtcaccct gcctacaaca 2758681 ttaatcgtaa gacaaagctg cggatgtaca gcaaaggagg tgacataagc aaagattcat 2758741 cacgatgata aggaggaaaa gatgaaacac acttttgttt tatttctctc tcttattctg 2758801 cttgttctgc ccgggtgttc agcagagaaa agctcagcag ataccgcaaa aaagacgtta 2758861 accatttatt ctacaatgtc aaccgacagt gaaagagata cgttcagaaa actagcggca 2758921 gcattcgaaa aggaacacag tgacattcat gtcagccttc atttcccagg caatgactat 2758981 gaaaatatga tgcgtgtcag aatggcggcc aatgatttgc cagatctatt cgatacacat 2759041 ggctggggga aaatcaggta cggagaatat acagcggatc tccgggatat gaaatggact 2759101 caagatcttg atcccaattt aaacagcatc ctcaaaaata aaagcggaaa ggtgtatgcc 2759161 tatccaatca atcaggcaaa agacggtctg gcgtataatc gcaatatttt agaccgttac 2759221 ggcattgctc cgccggaaac catggatgac tttatcaaag cactgagaac gattaaagaa 2759281 aagagcaagg gaagcattgt tcccttctgg tttgccggat atgacaaaag ctcattcgcc 2759341 caatattacg accaattcgc tacacctctt ctcatcacag accctgccca taatgaaaaa 2759401 aaacagctca tcaacggcac ttttcaatgg agtaaattca cttatttatc agaaatcctc 2759461 aaacaaatgc agaaagaaaa attgatcaat atcgacgccg tcacggcaaa aaaatcacag 2759521 ctcattgaat taatggccca aaacaaaatc gcctttacaa tgcaaggcgg cacactcggc 2759581 caagacgttg cccagatcaa cccgaacgtc aaggtcggca ttatcccgac acctgccatc 2759641 catcccggtg atgacccgat atggatcggc ggtgaacgct acacccttgc agcatggaaa 2759701 gattcgcctc aattaaaaga ggcaaaagat tttatcgcat ttatggcccg cccggccaat 2759761 gccaaacaaa tggctgaagc cacatcgctt ccttcagggc tgaccaatgt gaaagctgat 2759821 attttctacg caaacgatta tgagtattat caagatgtca aagtcgagcc ttacttcgac 2759881 cggttatact tgccaaacgg aatgtgggat gtcctgggca cggttgggca ggagctcgcg 2759941 gctgacattt tggcgcctca agacatttcg cagaagctgg gaagagaata taaacgactc 2760001 cgggagcaat ccgaaacaca gggagctgaa aacaatgagt gagatcgcaa gggacgttca 2760061 tgtgaaacag gttaagccaa aaaagcagtc ctcactttgg tggatgtaca ttcctgcttt 2760121 gctctccgtt ctggtcttta tgatttaccc gtttgtgaaa ggcacattga ttacctttac 2760181 aaactggaac ggattttcac aagtctacca atgggttgga ttcgcgcaat atgaaaggct 2760241 gttttctgat cctgatactt ggcatatctt aaaaaacacg ctgcattacg ggcttggcag 2760301 cacctttttt caaaatgtgg tcgggcttct gtacgctctc ctcttaaatc aaagcattaa 2760361 aacgaaagcg gtaacaagaa caattgtgta tttgccggtg atgatcagcc cgctcattat 2760421 gggctacatt tggtactttt tcttctccta tgacggaggc gcgctcaacg atttgctcgg 2760481 ggtcttcggc atcagcccta ttaatgcgct cgccagtccc tcgctcaatc catggatcat 2760541 tgtcatgatt aacacctatc aatatgtcgg gatcgctatg gttgtctact tagccggtct 2760601 gcaaagcatt ccgaaagact actatgaagc ggcgcaaatg gatggcgcga aacaaggcca 2760661 gcagtttttt accatcacgc tgccgctgtt aatgccctcc attaccatta atatagtcat 2760721 caacattatc ggaggcttaa agctgtttga cgtcatcatt gcactcaccg caggcggccc 2760781 cggaaatgcg tcacaatcca tgtccacgtt tatgtatgat ttgtatttca aacggcagga 2760841 tgccggctat gccgcaacgc aaggcatatt tatggcattt gtcattttga tcatcagctt 2760901 ttgcgcgctt gcgtacttta aaagaaagga gacggaaatg tcatgagagc cgcccgtaca 2760961 aaaagcatgc ggatcattac gcttcttgca gccattgtgg cctgtgcgca ttttattcct 2761021 ttttatatcc tgctgaccac ttcattgaaa gcaaaaggag actacagttc gaaatggata 2761081 tttccagccg acatctcctt tcataatttt tcagaggcgt gggagcgcgc ttcgctagga 2761141 aactctttta taaacaccat gatcatcaca ggtttttctg ccttgttatt aattatattc 2761201 ggctcacttg ccgcctaccc gcttgcccgg cgggaaacga aactgaataa agccgttttt 2761261 gccttgctga tttccattat gatcatccct ccgttaacgt ccatggttcc tttgtaccga 2761321 atggtcgtgg acgccggaat ggtcaataca cacgcaatcg ccattttcat caatacagcg 2761381 gcttacatgc cgttaaccgt attcttatat tcaggcttta tccgatcgac cattccaaaa 2761441 gagcttgtag aagccgcaag aattgacggt gcaggcatgc tgaaaatctt ttttacgatt 2761501 gtgtttcctc tgctgaagcc gatcactgcg accatctgta tcatttcttg tgtctttatt 2761561 tggaacgact atcaatttgc cattttcttt ttacaagatc aaaaggttca gacattaaca 2761621 gtagccatgg caggtttttt cggagaaaac gcaaacaacc ttcatttagt tgccgcagcg 2761681 gcacttatgg caatgctgcc gatggttgtt ctgtttttgg cgctgcaaaa atactttatt 2761741 gccggcctgt cttccggagc ggtaaagggt taacattaaa gggggaagca atatgaaaaa 2761801 gattacattt atcggtgcag ggagcacgat tttcgccaaa aatgttttgg gagactgcct 2761861 gttaacagag gcactgaatg gatttgagtt cgctctttac gacattgatc ccaaacgcct 2761921 gcaggaatcc cagctcatgc tcgaaaatct aagagaccgt tataacccaa gtgtggccat 2761981 caacagctat gatgacagaa aactcgcctt gcaaaacgca ggctatgtca tcaatgcgat 2762041 tcaggttgga ggatacaaac cgagcacagt catcgatttc gagattccta aacggtatgg 2762101 gctgcgccag acgatcgccg atacagtagg catcggcggg atattcagat ctctcagaac 2762161 aatcccggtc ttatttgata tcgcaaaaga tatggaggaa atgtgccctg acgcatggtt 2762221 cttaaactat acaaatccaa tggccactct tacaggcgcc atgctccgct ataccaatat 2762281 caaaacaatc gggctctgcc acagtgttca agtgtgcacg aaggatttat ttaaagctct 2762341 cggaatggag catgacggaa ttgaggaacg cattgcgggc attaatcata tggcttggct 2762401 tttggaagtc aaaaaagacg gcacagattt atatccagaa atcaaaagga gagcgaaaga 2762461 aaaacaaaaa acaaagcatc atgatatggt gcggtttgaa ttaatggata agttcggcta 2762521 ttatgtcacg gaatcgtccg aacataacgc agagtatcac ccgtacttta ttaaacggaa 2762581 ttaccctgaa ctgatcagcg agctgcaaat cccgctcgac gaatatccga gaaggtgcgt 2762641 caagcagatt gaaaattggg agaaaatgcg ggatgatatc gtcaataata aaaaccttac 2762701 gcacgaacgc tcaaaggaat atggttcaag aattatagaa gcaatggaaa caaacgaacc 2762761 attcaccttc ggaggaaacg tcttgaatac agggctgatc accaaccttc cttcaaaagc 2762821 ggttgtggaa gtgacatgcg tcgccgacag aaaaaaaatt acaccgtgct tcgccggaga 2762881 actgcctgag cagcttgcag ccttaaaccg gacgaatatt aatacacagc tgatgacaat 2762941 cgaagcggct gtcacacgaa aaaaagaagc ggtttaccaa gctgcaatgc ttgatccgca 2763001 tacaagcgcg gagctttcca tgaaggacat catctccatg tgcgacgatt tatttgcagc 2763061 acacggcgat tggcttccgg aatacaaata aaaactaggg gaccgctctc ccctagtttt 2763121 ttggttttgt ttcgccttcc caggccatca tgccgccttc aacattgact gttttaaagc 2763181 cttgctcatc caggtacttg cagacgttca tgctgcgcat tcctgagcgg cagataaata 2763241 cgtactcttt gtctttatca agggtttcca ttttttcagg aatatccccc atgcgaatat 2763301 gaacggcttg cgggatcatg ccttccgcta cctcttcatc ttctctgaca tcaattaaat 2763361 ataattcttc gtccgcctca attttttctt tcaaagcggc tgtgctgatt tcttttattt 2763421 ccaaagaaaa cactcctatt cacagtgatc atgttcagta tatcaaagtc agccgaacga 2763481 ttgctattct gagactgatg aaaaaaaatc cccttttggc aaaggggatt ttttctaggc 2763541 ttagtttgcc acaatattga caagcttccc aggcaccgcg atgattttcc gaatcgtttt 2763601 gccttcaagc tgctctttga ccttttcatc tgcttgagca agctgttcca gctgttcttt 2763661 cgttgcatcg gcaggaacct gtaatttcgc ttttactttt ccgttcagct gaacaacgat 2763721 ttcaacttca tcatccacaa gttttgtttc atcatataca ggccaagctt cgtaggcaat 2763781 tgtgccggaa tggccaagct tctcccatag ctcttccgct aagtgtggcg cgacaggaga 2763841 aagaagcttc acgaagcctt ccatatattc tttcggcagt tctgttgctt tataagcttc 2763901 attaataaag accatcagct gggaaatacc cgtgttgaaa cgaaggcctt cataatggtc 2763961 tgtgactttc atgaccgttt catgatagac gcgctccaat gtttcacccg cgccttcaac 2764021 gatttttcca ttaagctcac cgctgtcttc aataaatagg cgccatacac ggtcaaggaa 2764081 acggcgcgca ccgtctaatc ctgattcaga ccaggcgatt gaagcatcaa gaggtcccat 2764141 gaacatttcg tacaatctca gcgtatcagc accgtgagag gccacgattt cgtcaggatt 2764201 gacaacgttc cctttagatt tactcatttt ttcgttgttt tcgccgagaa tcattccttg 2764261 gttgtacagc ttttggaacg gttctttcgt cggcactacg ccgatatcat aaaggaactt 2764321 atgccagaag cgggcataca gaaggtgaag cacggcatgt tctgcaccgc cgatatacat 2764381 atcgaccgga agccattttt ccaatttttc tggtgatgcc agctgatccg gattgtgcgg 2764441 atcaatatag cgcaagaaat accagcagct tcccgcccat tgcggcattg tattcgtttc 2764501 tcttcttcct tttttccctg tctcagggtc tgtgacttcc acccactctt taatgttcgc 2764561 aagcggtgat tcgcccgttc cgctcggttt gatttcatcc gtttttggca aaatcagcgg 2764621 cagctcctct tccgggacag ctgttgacgt tccgtcttcc caatgaatga ccggaatcgg 2764681 ctcgccccaa taacgctggc ggctgaagag ccagtcacga agacggtacg tcactttctt 2764741 ctcaccgttt ttcgtttctt ccagccaagc gatcactttt tcaatcgctt cctgtttgtg 2764801 aaggccgttc aggaaatcag agttcacgtg ctcgccgtcg ccagtatagg ctgcttcctc 2764861 aacgttcccg ccttttacga cttccttcac cggaaggccg aatgttttgg cgaattcaaa 2764921 atcacgctca tcgtgtcctg gaactgccat gacagcacct gttccgtatg atgcaagaac 2764981 ataatccgca atccaaatcg gcagtttttc tccgtttaca ggattgatcg catacgctcc 2765041 tgtaaatacg cctgtctttg ttttcgcaag atctgtgcgt tctaggtcac tctttgattg 2765101 aatttctttg atataagctt caacagcttc tttttgctct gccgttgtga tgttttccac 2765161 caatgcgtgt tccggggcaa ggacagtgta tgtagcgcca aacagcgtat ctggtcttgt 2765221 tgtaaacact gtaaaggaat catcatgtcc atctatagca aaatgaacgt gagcgccttc 2765281 cgaacggccg atccagttgc gctgcatatc tttaatgctt tccggccaat caagctcttc 2765341 caagtcctca aggagcctgt ccgcataagc ggtgattttc agcatccact gcttcattgg 2765401 gcgtctctct accggatggc cgccgcgttc gctcttgccg tcaatgactt cttcgttggc 2765461 aagaacagta ccgagcgcag ggcaccagtt tacaggcact tcgtcaacgt aagcaaggcc 2765521 tttttcgtat agctttaaga aaatccattg cgtccattta tagtattcag ggtcagtcgt 2765581 attgatttcg cgatcccagt catatgagaa gccaagcgct tgaatttggc ggcggaagtt 2765641 atcaatattc tgcttcgtaa acacagcggg gtcgttccct gtgtcaagcg cgtactgttc 2765701 agctggcagg ccgaatgcgt cccagcccat tggatgaagg acatcatagc cctgcatgcg 2765761 cttcatgcgg gacagaatat ccgtagctgt gtatccttca ggatggccga cgtgcaaccc 2765821 agctccagac ggataaggaa acatgtccag cgcgtaaaat ttttgttttt cattattatc 2765881 aagagtggca aatgttttgt tttcaagcca atatgtctgc catttctttt ctatctcttt 2765941 gtgctgaaaa ctcaaagtaa aaacctcctt ctgattgaat acggcgtgta tggttcaagt 2766001 attgacggga aggagaggat tatattcaga atattcccaa actaaaaaaa actccctcat 2766061 cccaaaaagg gacgagagac tttcgttttc ccgcggtacc accctcgtta gcgcggcata 2766121 cgccgcactc acttgatact tttaacgcag ttatgcgtca gcggcttttc accgctgcaa 2766181 ctctgaggtg agttcggaaa caaacttgat tgactttcac cagccgtcaa ctctctgcaa 2766241 caatatctgt ttcttactgc tcctcttcat tgttcttatc gcaaccgtaa tctaactgta 2766301 ttttatagaa ttctgttcat aagtgcaagc aggtttgtat acaatgggaa tgtaccctga 2766361 acgggcggag attgaggaca attattcggg tggagttttg gtttgacgtt tggactcggc 2766421 cggttcgccg ccgctgttca gttctctcac aaagtcaaaa cttctgagaa cagcttcacc 2766481 gccgtagcct gagataatgg ataagatgac aagttgaatt cctgaatcgg ggtcagcgga 2766541 taatacaagt aaaatggaag ccgtcatgcc gataaaccaa tcttccaaaa atccaaggta 2766601 gataaaccgc ttcgtcattc tgggcttctc cagcctgcct ctctttttca catgaccgag 2766661 aatccccatg attcctccaa ttacacaagc aatgagtacc tgatgcagca tcttcatcat 2766721 caccttccta aagcccttat ttcgtaaagc gacttcaggc catccagccc ccttaaacga 2766781 ttccgatgat tttcgatatc tacataccgg caaatctgta aaaagcttgt ttcttccatt 2766841 atatgtgaac acatgatcgg taagcttgat gcattggatt catttttcac ccagtgacat 2766901 tgacctagtc acctatttag catgtagaaa acctttccgt tcatatgttc aaattctgtt 2766961 cttattttta gtgtatacga ggacaagccc taatgacaaa caacaaactg cacttgcttg 2767021 aatcagaaca tgtgttgtgc tacggttact gtagaattca tttttaaaaa ggggaatatc 2767081 aggctttcgc atagcaagct gacggcctaa gggggattta tatggctagt tttcaatcat 2767141 ttgggatacc aggacagctg gaagtcatca aaaaagcact tgatcacgtg cgagtcggtg 2767201 tggtaattac agatcccgca cttgaagata atcctattgt ctacgtaaat caaggctttg 2767261 ttcaaatgac cggctacgag accgaggaaa ttttaggaaa gaactgtcgc ttcttacagg 2767321 ggaaacacac agatcctgca gaagtggaca acatcagaac cgctttacaa aataaagaac 2767381 cggtcaccgt tcagatccaa aactacaaaa aagacggaac gatgttctgg aatgaattaa 2767441 atattgatcc aatggaaata gaggataaaa cgtattttgt cggaattcag aatgatatca 2767501 ccaagcaaaa agaatatgaa aagcttctcg aggattccct cacggaaatt actgcacttt 2767561 caactcctat tgtcccgatt cgcaatggca tttcggctct tccgctagtc ggaaacctga 2767621 cagaggagcg atttaattcc atcgtttgca cattgacgaa tatcttatca acatccaaag 2767681 atgattattt gatcattgat ttatccggat tggcccaagt gaacgaacaa acggccgacc 2767741 aaattttcaa gctgagccat ttgctgaaat tgaccggaac tgagttaatc attactggca 2767801 ttaagcctga attggctatg aaaatgaata aactggatgc caatttttcg tcgctgaaaa 2767861 catattcaaa tgtaaaggat gccgttaaag tgcttccgat tatgtaaaaa gatcccgctc 2767921 acccagctgg atctttcaga ttgttgacaa aatcctaaaa tggttttcat tttaggattt 2767981 tgtcatcttt tcagcgtgat tgaaaaccct tgaagtctag gaaggacgag cataggagcg 2768041 gagcgaatgt tctaattcgt gagcaccgaa gcgcaggcct gacaacgaat gcgagggttt 2768101 gtcgacacgc tgaaagatcc cgctcattcg gcgggatctt ttattatgaa gagattgatg 2768161 cctgcttatt tgtttcttta gctgatttta tccgtttgtc atatagaagc gttgtggcaa 2768221 tactgatcag cagcaatacc aacagagata aaacaagagc cctaatgccg taatgatcga 2768281 caagcactcc tccgaacagg ggaccaatca ttctgccgcc tgtcgccgca ctgttgacaa 2768341 agccttgata aaagccttct ttccctttag gggcaagctg attggcaata gtcggcacag 2768401 caggccaaac aagcatttct ccgatagtca ggatcaccat cgcagcgaga aacatcggaa 2768461 attgctttgc agtcagcagc atgctgaaag acacaataaa aatgataaag ccgatgacca 2768521 tttgcgcttt tagcgactcg gcccattttt tcaccacaaa actgacgagc ggctggccga 2768581 gcacaatgag aattccgtta accgtccaca gcacgctgta taaggaaaga gatattccaa 2768641 tgctttgtgt gtacgaagca attgtggttg accactgaga ataagccagc catccgagta 2768701 catagcctcc gcttaaaatg atcagtgcgg caaattttgc tttgctgttc acagcatcat 2768761 aatcaagcac ggatgtttgg gatgcatcgc ccgtttgaat atttcgaaat ccgaaatata 2768821 caataaagaa aaagatcaga tacaatacgg catttgccaa aaatacatat gaaaacgaga 2768881 aagatgccac gacaccgcca agcgctgaac caacggccac gcccgcgttt tgcgcgacat 2768941 atatcgcatt aaatgccttc cttccccctt caggccatac cgatcccgcc attgcgtagc 2769001 ttgccggaaa aacaacaccg gagccaaagc ccacaatcgt cagcagcaca atataggctg 2769061 gccaatcatg aaaaaagaca agacccatca ggcttgctaa cgtaatggct atcccaagca 2769121 taatcgattt aaaaccgccg attttatcaa acaaaaaacc tccgcataaa ttgccagcca 2769181 cactggcgcc ggaattcagc atcaggacaa gtccggctac tgttaacgac tttcctaaat 2769241 gattatggat ataaatcgta ttcagcggcc ataaaaaaga agcacccgtc acattgataa 2769301 acattccaat gactaaaatt ttaagagcac gcggcatact catccccctt tcttacctaa 2769361 aaaagctcat gaaaaaaacg aaacctaaaa cggctccgta cgaatccagt tatcatagca 2769421 cattcattct atctgtctct ctcacatttt tcaactgatg agcgtgaaaa aatctaacaa 2769481 atattgtttg aaaaatgtaa aataaataga aaaaggggtc atattatgga aatggtatta 2769541 gcattcttag gttttctggc atgtctcatt gcactgggct atggattata tcaccttgtc 2769601 agatatgtac tgaaaaagga aaaacgtttc tcaaagagac ttttttggcc gcttttcatt 2769661 ggaggccttg tgctgctctt taccggggca gcattggcag aacctgacac tgccgcagca 2769721 aatgccgaga aaaaatattc agcgctaaac gccgaatata aaaacctcac aaaagagcac 2769781 gaagaacttg agaaagaata taaatctgtc agctctgaag caaagaaatt aaaagacaac 2769841 aaagaagatc aagacaagct tgagaagctt aaaaacgaaa atagcgatct aaaaaagact 2769901 cagaaatcat taaaagctga gattaaagag cttcaagaaa atcaaaagca gctcaaagaa 2769961 gatgcaaaaa cggcaaaggc tgaaaatgaa acacttcgac aagataaaac aaagcttgaa 2770021 aatcaattaa aagagacgga aagccaaacc gccagctctc atgaagacac tggaagttct 2770081 tcaaacaata cgagtaaaag tgatgaaacc aaaacagctg acaaagcaga aggctgtaat 2770141 atcaaaggaa gcagaaacgg catctaccac acgccaggca gtacatacta cgaccggaca 2770201 accgatccgg ctgaaatgtt ttgctcagtt gaagaagctg aagccgccgg ttatcgggcg 2770261 ccaaaacgat aaacaaaaag ctccagaatg tctggagctt tttctgtttc acaacgacga 2770321 tttaatgacc ttcttataat aaagaactga cagaaaacca aaaatggagt agagcgcagt 2770381 atataacacc atcaccataa tcataggcgc ccatacctct gatccgaata agaaccagcc 2770441 ggattggacg gcaaagtaac tgtggaagag gccgacaacg agcggaatgc cgaagttgta 2770501 catttgtttg atgcgtatcc cctttatcag gtcgccctgc gtaaagccga gttttcttaa 2770561 aattgtatag ctcggttttt catcttcact ttcacccatt tgtttaaaat aaaggataca 2770621 acctgatgta atcaggaacg ttaaccctaa gaagccgacg atgaacatca ccataccaaa 2770681 cagtgatttt tgcgcagcgc ttgtatctag tcttgataaa tgctcgtttt tcttgttcac 2770741 ctgttgaaaa agctcatttg ctttttccat ttgatcgtca tgtttcacat tgacgccgat 2770801 aaatgtagat tgcgccagct gaatgcgggg gtctttatcc ttgtccagct gtttaaacag 2770861 gctgtcatcc acaatgacag cgggcatgcc cccgcttgta aacgtgtagg acacaagaaa 2770921 ctcttctctt aatcctttat attttaatgg ctgcgtctcg tgcttgcttt ttactttaat 2770981 aacaccagag tccttgaaaa ccattatttt ttgcagcaag tcggtgtatc ctgagaaaac 2771041 ggcttctcca gccgccacat cgactccttt tacatctttg tcgctaacaa cagcaagctg 2771101 catattgccg ggatcgccct gcatctcttt cggagttcca tccataatat ttgcaatgtc 2771161 aacatttgct tgcaggacag gtgttgcctt ttttacaaac gagatgttgc tttccctcaa 2771221 tttgttttca aataacttgg catctttctc attcatgaat gaaaaatcag ccgctacatt 2771281 ttgttcagcg gtcttttccg acgagtaata cgagatgtaa gcaagagata acagcccgat 2771341 ggcgagcgct gaaacggttg taataatcgt cagcagcagc gcattcgatt tcattctgaa 2771401 catgatcgaa gacagtgaca gaacctcaga aatatttaag tagccgccct tgctttttcg 2771461 aatgatattc gagataaacg taactgatcc tttataaaac aaaaacgtcc cgataatgac 2771521 gctccccaga atgaagctca tcgcaacaaa cagttcatta atggtcttaa attttccgcc 2771581 aaacagctca gaagacacat agtatcctgt caaaatcaac acgatgccta aagcgccgat 2771641 cagcatttgg aaaaatgata ttttcttcac tttgtcttca gtggaggacg ttactttaaa 2771701 caaagataaa atactctgtt ttttgataaa cgtataattc atgatcatga tcaaaaggta 2771761 aatgccgcag aacacaatga ccgtttggac caaggcctgc tcagaaaaat gcagtttcgc 2771821 atccgctttg acatcgacaa ttttgaacag aatcatcaag acaagcttcg atatcgaaaa 2771881 cccggccgct accccgatcg ctaatgaacc gaaatacagc atgacatttt ctgcacttaa 2771941 gatgcgaaaa attttatgct tcgtcattcc aattaattga aacagcccga tttctttact 2772001 ccgtctctta ataaaaatcg tattggcata taaaatgaag atcgccacta cagccacaag 2772061 caaaatcgaa gcggttttaa tagccgcggc tcccttgatt gaagccttca cttcgttaat 2772121 tgctggatca tactgcagcg tgacaaaggc gaaataaagc gccacgctaa agatgagcgc 2772181 aaacacatac aaatagtaat tccggagatt ctttttcaaa tttcgcagga tgagctgatt 2772241 aatgttcatg ctgcaccccg cctaacacgc cttgcgtttt cataatatcc tggaaaaacg 2772301 tttgcctgtc ctggccccct ttattcagct gtgtatacat ttgcccgtcc ttaataaaaa 2772361 tgactctgcc gcagtagctg gcagcgacgg gatcatgggt aaccataata atcgtcgcgt 2772421 tgcgtttttg attgagctgg ctcagcttat ttaatagatc ggaggccgat ttcgaatcga 2772481 gcgcgccggt cggttcatca gcgaaaataa tgctcgggtc atgaataaac gctcttccag 2772541 cggatgttct ctgcttctgg ccgccggaaa tttcattcgg gtatttatcc cgcaattcat 2772601 atattcccag ttccttggca acttcctcaa acttgcgatt ggcttccttt tttgatagtt 2772661 tcgtgatcga taaaggcaga aggatattct ctttcactgt caatgtgtct aacaaattgt 2772721 aatcctgaaa gataaagcct aaatgctgtt ttctaaattc agccagctgc ttttccttca 2772781 tagccgtcat gtcatttcca ttaatatgaa tggttccgtg actgacctga tcgattgagg 2772841 acagaacgtt gagcaaagtg gtttttcccg acccggaagc acccataata ctgacgaatt 2772901 cgcccttttc aatgtgaata tcgatgccct tcagcacttc ctgtttattc agcttgtttc 2772961 cataactttt tcgaatttta ttcgcttcta aaatcaccat ttacgcagtc tcctttatat 2773021 tggataatct cattataaaa aggaatgccg ggcttttcct tcgatacggc gaacaaaaaa 2773081 gaaaagcatg tgacattttc gtcacacgct tatgacatgt tcaaattgat tccgtattgg 2773141 aaaggttaat gtaaaaactg ttcccgcacc aaactccgac tcaacatcaa tatggatcaa 2773201 taacggcgcc gctgcttttt ttgccaagta cagccccatg ccagttgacg cttgatcatg 2773261 gtgatccgtt gtggatgtaa accctttatc aaaaatacgc ggtacatctt ttggatcaat 2773321 gcccctgcca caatctttca cttggagctg cgtctgttcc cctttttgaa agcttttgat 2773381 ctcgatttca gaggcttcgc tgtatttcac cgcgtttgtc agcagctgcc tgatgataaa 2773441 cgccagccat tttgcatcgc tcagcacttc tttggcctcg agctgtatgt caaaaccgat 2773501 ccctttttgg atacaccacg attgtaaatc tttgatttct ttaaagatca aaggctgaag 2773561 ctgaatgaat tctactgaca ggtcgttttc aataaatgaa atgcgttttt gatgaagctg 2773621 ctgatcaaga agcaggtgaa tacgcagcca ttcatatgac agctgggatt tcagtgcttt 2773681 ttcttccatt ctatcaatga ttaaatgcat cgctgttaat ggagttttga cctcatggat 2773741 ccatgccatc agctcatctt tttcattttc caatgctaag cgatgccgtg ctgcggtctg 2773801 cttcaagtgt tctgtttgcc cggcaatgct tctttcaacc attgcttcaa acggcgtttc 2773861 cggttcattt atggctgtca catcgagatt gttctcccat gttttcaagc ttttataaaa 2773921 cgctgtttct ttccgatagc ggaaccaaag gaatatgata aaaaacaaga tgcacaaata 2773981 caccatataa agtacattcc caaatgatat ggaaggatcg acaaaagcaa tgaacagcat 2774041 caaagcctgc tgaaacaaaa acgcggcaat ccagctccgc ctttcgataa ggaatgcttt 2774101 aatcatagaa cttgtcctct tccttcgcga tgtagccctg gcccaccttt gtctcgatat 2774161 atgcaccaag ctgcagggcg tccagttttt ttcgcaggcg attgacattg acggtcagcg 2774221 tattatcact aacaaaacgc tcatcgttcc acaagcttct gatcagctct tcccggctga 2774281 cgatcttgtt tttttgctct attaattgtt ttagaatgaa catttcattt ttggtcagtt 2774341 caacagatcc tttgtcattg ctgacgaggt tctgctccgc gtctacagca gcgccgcacc 2774401 acgttttaat cgtactcggc tccgtattat aatggtgcac acgccggaac atcgcttgga 2774461 ttttcgcgat cagcacatca aaatgaaatg gcttttgaat aaagtcatct gccccgagct 2774521 gcatggacat caccatatca gcaggatgat cccgggagga taaaaagaga atcggaacat 2774581 ttgaccggga gcggatcaga cggcaccaat gaaagccgtc aaatttaggc agctgcacat 2774641 caataatgac acaatcagga ttaaccgccg caaattcctg cagcacctga ctgaaatcct 2774701 gaatgccgta tacatcatag gaccatcccg ttaaacgatc cttgatttca tgaaacagcg 2774761 attcatcatc ttcaatcagc aaaagtttaa acaatcgact caccgcactt tttccttttt 2774821 tatcaagtgt atagcaaaac gccagcatgc gctatagaaa aagccggctg tctcagccgg 2774881 ctcgttcgca ttataattct cttctcaacg ctgtcagcac gttggttttg gtagcttttc 2774941 tcgccgggtt cattccggaa atgactgcga cccctccgca aatcacaacg gcaatgatca 2775001 caaggctcgc cgggatgtag gagaatgtgt aattcaaatc gcccgcatcg ccaccgcttg 2775061 tggccgcaag aatcatcgga acggccaggt tgacaaggta gctcacgccg taagaaatga 2775121 taatcccaat cacacagcct aaaattccga tatacgcgct ttccatcaag aacattcggc 2775181 gaatgattga cgggctcgcc ccaatcgctt tcataatgcc gatctcttgc gttctctctg 2775241 tcaccgccat cgtcatcgtg ttaaaaatgc cgatcgctga aatgataact gcgatacatc 2775301 cgacaaagat cagtccgatt ttgaagacca tgaagaaggt attggctccc tcaagttcag 2775361 tagtcactga tgtgacatag tacccgtcat ctgttagatc atttgtcagc tgttccacat 2775421 tctcaaactt atcagcaaaa acaccaatgt tcgtttcaac atttccgcct ttgaaatcta 2775481 agaattccga aaaatctttt ttgaattgat cactgataaa aatatttgag tcctccatcc 2775541 agtcttgaga tggttttttt gtaataccga caattttaaa gtcatatgtt tttgtttttg 2775601 taacatcccc tgttttagaa tctgtcttcg atacacttag ttcaattgtt ttatttagaa 2775661 tatctttcgt atagcccttt ggttctttta tatcttctgg atttcctttt gcttcctcga 2775721 tttttttgtt atattcttcc gattcttttt tcgttaataa tctctttgcg aagtcgtatc 2775781 ctactacgat ttcattttcc gactttgcga ctcttccctt ttccaattcc atattggcct 2775841 ttaattcatc attcatatta gtaaaaatga gatttgagct ttcatttgta cgattgccta 2775901 aagtagcttt gtttggttca tacacttgcg ttctttctac aactgacctt acgtgatcat 2775961 acttctctaa atcagctttt ttaatcggct tgtctccttc cttgcccatt acgctgactt 2776021 tcgttacaat ctgctggctc attgtcatat ctgtaatcgt cttttgaatc ccaaatccaa 2776081 cggacgacaa cacaaccaaa aacgcacacg ccattgttgt cgccagaatc gtcataaaga 2776141 cgcgaagcct gtttttcttc atatttcttc tgataaaatg aacctgatcc ttaaacctca 2776201 acggtaattc ctccttttag cacaccatca tgaagctgaa attttgaatg tccgatagaa 2776261 gcgacttcat catcgtgagt aatgatcaca aatgtaatgc cacgctcacg attcagctgc 2776321 tggatcaatt ccagcacttc atgttccgtt tctgaatcaa ggcttcccgt cggctcatcc 2776381 gctaagataa tcgaaggatt taaaatcaat gctcgagcaa tactgacacg ctgctgctgg 2776441 ccgcctgaca gttcattcgg ataatgagcg gcgtggtttt ccagaccgac gcgtttcagc 2776501 atgtcctgca ccttttgctt ccgctcagat ggcttgattc cttttaacgc cagcggcatt 2776561 tccacattct catacgtcgt taaacccggg atgagctgaa agctctgaaa aataaacccg 2776621 aaatggtcaa gccgaaattg cgcccattcc ttttcattaa accccgtaac atcagtgcca 2776681 ttaatgacaa tccgcccttt tgtcggcgat atgtagccgg aaattaaatt caaaagcgtt 2776741 gatttccctg agccgcttcg tccgacaatg caggcgattt cccctttcgc cacgctcaat 2776801 gaaacatcct tcaatactgg aacttcattc tcacggccct tttttccgat cgtgaaagaa 2776861 tggtcgatat gctgaacatc aatcatatgt tctctctccc ttacaaaagt ttcatttttt 2776921 tataaatcgc aaaataacta atcaagaaac cgattaccgc acctgtaccc atgccaatga 2776981 gataaccggc aaagctctcg cttgcagtaa atccaaaata gccgaagccc atgattccta 2777041 tgataataac gatgatctgc accgggcggt taagcggctt ccataagaag aaatatccgt 2777101 ttctttcatt agacatttta acaaagctaa tatagccgat gatgtaaaaa atgatagtca 2777161 tgatagccgg aatgactaaa taatatggtg aattctcagc ccatttcgag tctacataaa 2777221 ttatcggaat gaaatactgc acccatttag gtactggacc atggataaaa tctattgatc 2777281 cgccaaaaag gatctcgagg ttgatcacag gcaggctgat gagtaaaaac ggcgaaatgg 2777341 ccacggtaaa tgagactaga agctgtgcga aactattgcc tgtcaaagct cctccggcca 2777401 taaccaaaga ataagccagc atgctaacaa taatcattcc caagctgtaa ttgtgaaaat 2777461 aaacggcctg atctggcttc aaaagcatga tcagcaaaac agacaaaaca taacctatga 2777521 gctgcggcac cacaatcacc attccgccgg taaggaactt cgcatgaaat atctgccctc 2777581 gtgtatatgg aaggcttaat gtaaaatcaa agaagctctt gctacgttca atcccaagct 2777641 ggctgaccgc caaaacgact ccccaaatcc aaaacaatga gataaatgag ctatttaaat 2777701 aatcaacgct gaatacgcag gggccgaccc aattttcttt tccagtgaca cagccttgat 2777761 agatgagata catatttaaa attgataatg gattacctaa tataaaaacc aaaatggtga 2777821 taactaaggc gactttattc tgccgccact ctttgtaaag cagtccggaa tccggcaact 2777881 cacttccctc caaacctaag gcatttctta cacttttgtt ttcttataaa tagagaagta 2777941 gctcacaaag aatccagcca ctgctccaat gatcataccc aaaatataac caataatgga 2778001 atgtccggta tagtatccaa ataaaccaaa tccaaggatg ccgaaagcca taaccagaat 2778061 ttgcaccggg cgatctaatc tgttccataa gaaaaagtgt ccgttccgtt cacttggaag 2778121 cttcttgaag cttataaagc caatcaagta aaatagcatg ctcattacgg ctggaatcaa 2778181 taaaagatat ttactgttaa tcagccattc atttacaacg taactaatcg gtactaggtt 2778241 cgataaattg cttgccagag agaaataact ctcaggggaa gggaatattt cccatatatt 2778301 cgcaccaaaa acaacttcta ggtttccaac cggcaatgca ataattaaat acggcaatat 2778361 agctgctgaa aacgccgtta acagttgggc aaaagcattt ccagttaacg ctccggcggc 2778421 catcaccagt gaaaaagcca taaaacttat cacgattact ccaatgctgc tgtgctcaaa 2778481 aaagtagacg tgttcagggt tatagacaag aatcagcagc catgcaagta aaaagccaat 2778541 caattgtgac agcacaatca caaaaccgcc taaccaaaat tttgtctgaa aaatttggct 2778601 tctgttatac gggaggctta atataaaatc catcgtgcct ttcgaacgct ccattccgag 2778661 gaagcagacc gccaaaatga cacccggcac ccagttgata tctatcagat tgcttatgga 2778721 ataattcaca ataaaatcac aatattgcgg gtcttggcga tcaagacacc cttgataaga 2778781 caaatacgta ttaacgatag aaagcggatt tgccaatact aaaaacgcga tacttaacaa 2778841 aatcaccact tgattctgct tccactctcg atagaggaga cctcggtcta ccatctccgc 2778901 ttccctccaa acttcgcaat gaacacttct tccaggttga caggaagctc attccacact 2778961 tttggcttca gctctctcaa aaagctcttt ttctcctcat cgcttttcgg aatcagcact 2779021 gtgtaaaaca cgccggcctg atcgagcatc ggaatgtttt gctctctgat ggccaaattg 2779081 acatctgtat cgaaggccat ttgaatttta atgtattctt cttttaactc atcaagatcc 2779141 atgacgttgg tcaggctgtt atcttcaaga aaaccaattc ggttgcacat ccgctctatg 2779201 tcttcaagcc ggtgggacgt aatcaggatg ctcgtatcac gctctgccac ttcatcgacc 2779261 atcagctgca gcacatcatg ccttgtcacc gcatcaatac catccgtcgg ctcatcaagg 2779321 aggatcagcg ccggtctcgc cgcaaacgac agaacgagcg atagctgctt ttttaagcct 2779381 gtcgacagct cacggtattt tttcgtttcc ggaatttcgt atctgttcat cagctcattc 2779441 gcgtacgtga catcaaattt cggatatatt cttctcaaaa tatcgactaa ctgcttgtat 2779501 gtatacttat cgtaaaacgg attttgaaca ggcatgtaga tgatattttg tttgactttc 2779561 gggtgctttt tgatttctac gccgtcaaat aaaatcgttc cgctgtcagc gaaaatgatt 2779621 tgctggatta agcgaagcat cgtcgttttg cccgatccat tgcgtccaag caatccaaag 2779681 atttctcctt tttcgattgt taatgaaaca tcttttaata cttgattgcc gtcaatcgct 2779741 tttgacagct gccgcagttc aatcattttt tttgcctccc ttcacatcag cgctgatttc 2779801 ctttatccat tcgtgcagtt tttccagctc aacccctgca tagtgtgcat cgatgatgag 2779861 ctgtttgagt tgctctttaa tcatcgtcat cttcccttca accagtgtcg tttttgcatt 2779921 ctccgatata taggtccctc tgccccgcag cgtttcaata atcccctctc gctcaagttc 2779981 tttatacgct ttgctgacag tgttcggatt cgcaataatg atcgttgcca attctctgac 2780041 agaaggaagc ttatcaccag gcttcatgat ccctttcaaa caaagctctt tcatttgctg 2780101 aataatttgt tcgtaaatgg gtgttgagct tcttggatcg atttgaatca tttacttccc 2780161 tactttctat acgatctgaa ccttttatag ataaaaatga tcaattatac ttttttgcca 2780221 ttcaaaaccg atcatcacaa gaacaagaaa aaaagaacaa gcgatcacag atgccgcaat 2780281 cagcattggc acgttacgtt tgtttcgttt tttatgtttc ataactgcct cccttaatgt 2780341 caatatataa atgattttat attagtgtct atagtgtatt acttcaatta gtacacttaa 2780401 tacaataaat actttgactc acaaagtcaa tccttttttt acaaaaaaac ggaccctttt 2780461 aaaagggtcc gttttcctac acatcaagag ggtgctgcag gatcatatta ttttgcaaag 2780521 attgaagctg aagtctcatt ctgtacagct gttctctctg ctgatcattt gacgacagcc 2780581 atagtttatt caaggcattt accgcatctt ctagctgcat ttgtgcatca ctatattctt 2780641 gatcgttata atgctcttgt ttagaagcga ttttcagctg ttcttcagca taatcatagg 2780701 cctgcataca ttgctggaga tgttcatcta ctgattgtct tgttgccaca gtaacccctc 2780761 ctcttggtaa tggaaatcat ccatcattca tattgtagcc tcatctgact ttattcaata 2780821 aagtaattta tggtcgatat tcatttgttc tcttgtgaaa tgcgtgctac aattttagga 2780881 tgcaatcgta cgcaaggagg cacatgaatt gtgatgcaga acaatccttt tccttattca 2780941 aatacggaaa aacgctatca tacattgaat tatcatctca gagaacattt cggccataag 2781001 gtgtttaaag tagcgcttga cggcggtttt gactgtccaa atcgggatgg caccgtagcc 2781061 cacggaggct gtacgttttg cagcgcagca ggctccggag attttgctgg aaaccggacc 2781121 gatgatttaa ttacgcaatt ccatgacatc aaaaaccgca tgcacgaaaa atggaaggac 2781181 ggcaagtaca tcgcttattt tcaggctttc acaaacactc acgccccggt tgaggtgctt 2781241 cgtgagaaat tcgaatccgt cctcgcctta gatgatgtgg tcggcatttc gatcgccaca 2781301 cgcccggact gtctgcctga tgatgtcgtt gattacttgg cagagctgaa tgaacgtacg 2781361 tatttgtggg tggagcttgg gcttcaaaca gttcatgaac ggactgcact tttgatcaac 2781421 cgcgcacatg attttaactg ctatgtggaa ggcgtcaata aattaagaaa acacggcata 2781481 cgtgtctgct cgcatattat caacgggctg cctttggaag accgggacat gatgatggaa 2781541 acggcaaagg ccgtcgcaga tttggatgtc cagggcatta aaatccatct gcttcaccta 2781601 ctgaaaggca cgccgatggt caaacaatat gaaaagggca agctggaatt tctttctcaa 2781661 gatgattatg tgcagctcgt ctgcgatcag cttgagatca ttccgcctga aatgatcgtc 2781721 caccgcatta caggtgacgg accgattgag ttgatgatcg ggccaatgtg gagcgtcaac 2781781 aaatgggaag tgcttggcgc cattaataaa gagctagaaa atcgaggcag ctatcaagga 2781841 aagttctttc aacggcttga ggaggaatca gcgctatgat tttgaagaaa attcttcctt 2781901 acagcaaaga actgctgaaa atggccgcgg gagagggaga tattgtcgta gatgcgacaa 2781961 tgggcaacgg acatgataca cagtttttag cggagcttgt cggtgaaaac ggccatgtat 2782021 acgcattcga catccaagaa tcagccgtgg ccaatacaaa ggaacggctc ggtgacatgt 2782081 atcaagcgcg aacaacgtta tttcacaaaa gccatgataa aatcgctgaa tccctcccgc 2782141 ctgaaacaca tggcaaagtg gcggccgcgg tatttaacct cggctatttg ccgggcgggg 2782201 acaaatcaat tacgacaaac ggcagttcta cgatcaaagc cattgaacag cttctcagca 2782261 tcatgaaaga cgaaggtctg attgttctcg tcgtctatca tggccacccg gaaggcaaag 2782321 ctgaaaaaaa cgacgtgctc gagttttgcc gggacttgga ccagcaaaca gcccgtgtat 2782381 taacatacgg gtttatcaat cagcaaaatg acccgccatt tattgtcgcc atcgaaaaaa 2782441 aagctcagat cagcaaatga tttgagcttt tttctttgaa tttttcatcc aggacatttt 2782501 ttgaaatttc cggtaggctc tgccgttgat ataaaagaaa agggaggttt ttccgctggc 2782561 tttgatcagc ttctttgcga gccggcccat ttccttttgg cctgccactt tatcatctga 2782621 caaataaacg ccaagcaagc cgcgattgat taaacgatgg aagttttcat gcggaatgcc 2782681 ttgtaaatgc tcgtcggctt tatggataaa gtgttcaagc cggtccatca tctcttcatg 2782741 agactgataa tacgagcaga aattcaagtc tccttccagc aagtcctcct cttgatcaat 2782801 caaataatca agaagaatat gaagaccctg tatgtaagga aaataactgt ctcggatttt 2782861 tttagcggtg ctttctgtga aatcaggctg gaacgaatac gcaaccagac agaaaatgcc 2782921 taacgttgag cctgcacagg ctgaaaattc ataccattcc atctcaggca gctctgattc 2782981 atattgagta aaccactttt caagccgcgg aacacgctca tgctcaataa cgtgcttatg 2783041 cacctgcaaa tcgcaataat agccgcacag ttcaagcaga taaggtttaa tcatgtcata 2783101 gtgctcaatg gagccgagaa cacgctggca cgttttaacc agttcatgca aatatccgct 2783161 gtcatcctgt tcttccctga attgataata gttttgcagt tccgccccaa ctgtcagtgc 2783221 gtcctgcatt gaggcatgga gcatccgaaa atcctgcggg tccagcgagg tgctgcggtc 2783281 acacagattg tccaaataat cactaatcgt ttgatacgcg atgataaact cgacacattt 2783341 ctgcttttgg ctgcctgaca ataaggccag tatgccgccg ccttcacagt gaaacgtttt 2783401 gtcccgaata cttgcggttg cctgtgcttt caattcactg ttatgaatcg attctgattt 2783461 ttgcttccat atgtccagct cttgatgaac gagcggaaaa atatctcgat atacctttgc 2783521 catcaatcca aaaggatgtt ccggtactgt caacacatgc accccctact agttcaaata 2783581 tattgatcag taaacgctct tgctgcttta aaaacatctt ctctctcggg ttcattgaag 2783641 atctcatggt aaagcccttc ccactctctg tatgctttat tatgagaagc aacaccatta 2783701 aaccacttga tgaccatcgt tttgtcaaca agcttgtcat caccggcttg catcacaaga 2783761 agcggaactt tcaaaaatgc ctctgtcggc accattgccg attcaattgt ctttaaaagc 2783821 tctctgtacc atctgacaga aactttcctg acgtataacg aatcattttg gtcagcttcg 2783881 atgacgtcct cattgcgcgt cgccatatca attgataatc ccgaatcaac cttaagtgac 2783941 ggagcgatga cattcaggcc ttttgatgca agatcaagcg ctttattcac tttaatttgc 2784001 agtccgagac acggtgatga taaaataatt cccgtaatcc ggggatttct ttgctgttta 2784061 acccattcaa tcgcgaccag accgcccatg ctgtgaccta gaagaaaaac cggaagatca 2784121 aaggttcgcg ctttatctat ccaagcatct acttcatcaa tgtattcttg aaacgagcga 2784181 atatgccctc tcgctcttgt cgttgttccc tgtccaggca aatcgcccat gacaacgtga 2784241 taacccgaag accgccacat ttcaatcagc catttatatc gtccgtgata ttcacttgcc 2784301 ccgtgaatga ttacaatcac ggcaacaggt ctgtctgctt tccaggtcca catgatcttc 2784361 acctcatacg aaatttaaat agagaaagaa ggatgaatct tatgatctac ccttataagg 2784421 aacacaagcc agatatccac ccaacagcct ttatagctga taatgcaaca attaccggtg 2784481 atgtcgtgat cggagaacag tccagcattt ggttttctgt tgtcataagg ggagatgttg 2784541 cgccgaccag aatcggaaac agagtcaata tccaagattt aagctgcctc catcaaagcc 2784601 cgaacaagac gctactcatt gaagatgacg ccacgatagg ccatcaggtt acacttcata 2784661 gcgctgttat ccgcaagaac gccttaatcg ggatgggctc aatcatttta gacggagccg 2784721 aaattggcga aggcgctttt attggtgccg gcagtcttgt cccgcccgga aaaatcattc 2784781 cgcctggcca tctcgccttt ggccgccctg caaaagtcat ccgccctttg acggaagaag 2784841 accgaaaaga tatgcaaaga atacggtcag aatatgtaga aaagggccaa tattataaat 2784901 ttcttcaaca aacataagac ctgcttcgtc ttactttacc atttttcaaa ttatatttga 2784961 aagcaataac catcgttaac ccggacgtca tacagttcgg gtttcgattt ttccataaaa 2785021 cgttcacata tagcatgaaa cgtatgactt ttatcttatc acaaaactat aaacagcctc 2785081 tgcaaaaaca catacctatt ctttcctgtt ctctattttc tatgagcaca cacaaaaaga 2785141 gcccactggg agctcttttt gtcagctgat atttcgttcg ctggcagcag ccgcattttt 2785201 tttatgaaac ccttttccat agtacacagc cagcaagatg agaaaccata tcggcccgat 2785261 aatcacggct actcttgtat cagggctgta agccataaga atgacgacga atgctagaaa 2785321 tgccaatgac acataagacg taaacggaaa taaaggcatt ttgtacttta attgtttctt 2785381 ttcttccggc ttcaaacttt tcctgtattt tatttgagaa agcaaaatga ttgcccacgt 2785441 ccaaatcgct ccgaacgtcg caatacttgt aacccaagta aataccttcg cagggacaac 2785501 atagtttaac agcactccga ctaataaagc gcccgctgaa gccagaacag ctttacccgg 2785561 gatgccgcct ttcgtcagct gaccatatgc ttgtggcgcc tctttctgtt ccgccaagtt 2785621 aaacagcatc cgccctgtgc tgaaaatacc actgttgcat gaagacagcg cggctgtcaa 2785681 cacgacaaag ttaatgatac ctgcggccga tggaatgccc actttttgaa atgtgagaac 2785741 aaatggactt ccttgagagc caatttcctg ccacggataa atagacataa tgacaaataa 2785801 agcgcctaca taaaaaatca aaatccgcca aaatactgta tcgattgctt tggctaacga 2785861 tttttgcggg ttttttactt cgccagccgt caccccgatc atttcaatcc ctaaataggc 2785921 gaacatgacc atttgaagag acaataaaac cccttttaat ccatgaggga aaaatcctcc 2785981 gttgttccac aaattgctga ttccggttgc aatgccccca ttgccgactc ctgcaataat 2786041 catcaataaa ccgacagcaa tcatggataa gattgcaaca attttaatca atgcgaacca 2786101 aaattccagc tcgccgtaag ctttgacagc caggaaatta acacccgtca taatgaccag 2786161 tgccgataac gcccaaatcc agtttggcac gtccggaaac cagaacccca tatagatgcc 2786221 gacagcagtg atttcggcca tacaggtgac aacccataaa aaccagtagt tccaacctgt 2786281 taaatagcct gcaagcggtc ccaaataatc acgcgcatac ctgctgaagg agcctgcgac 2786341 cggtttttga atggccattt ccccaagcgc tctcataata aaaaacatga ccaggccgct 2786401 tgcggcatac gctaccaaaa taccaggccc tgctaattga atagctgatg cggagccgag 2786461 gaacaaccct actcctatag cagctcctaa agacattaaa gaaatatgcc tttcttcgag 2786521 tccgcggtgc agctcttgtt tttgtttttg catgcttctt ctcccctaga aaaaaatatc 2786581 attatatcat ttttctgaat attccgtacg gattgggtaa atcaatgatg atggagaaat 2786641 aaaaggataa caacaaggct ttcgactact cgaaagcctt gttgtctgtt acacaaagat 2786701 gacttcttta ggctgatggc tcagctcttc aggcatatac cgtttttcaa tattgatgct 2786761 gtgccagatc ataaagatta gcacagtcca aattttacgg ctgttatcag ccttgtccgc 2786821 acaatggtct tcaagaagct gaaggacata atccttatgg atataagcat ccgtttggct 2786881 ttcttgaata atattccgca cccattcgtt catttcgttt ttcagccaat gacggatcgg 2786941 tacagggaaa ccaagctttt tgcggtttaa tacgtgctca ggcacaattc cttcagcggc 2787001 tttgcgaaga agatacttcg tcgtgccgtt cttcgttttc agctcatcag gaatttttga 2787061 agcgacgtcg aatacgactt tatccaagaa cggcacacgc agttccaaag aattcgccat 2787121 cgtcatttta tccgccttta acaaaatgtc gccgcgcatc caagtgtgga tatcgacata 2787181 ctgcattttg ttgatatcgc tgtacgagct gctttctgta aagtaagtct tcgtcacatc 2787241 gcgatatgaa aggttcggat tataatgctt caacagctgc tttttgacag actcttcaaa 2787301 gattttcgcg ttaccgatat aacgatcctg aagcggagtg cagccgcgct caagcaggct 2787361 cttccctctc ataccttcag gcataacggc agcaacgtgc agaagcatct ttttcaagcc 2787421 ggacggaatc cgttcaaacg gtttaagcga aagcggttca cggtaaatgt tatatccgcc 2787481 gaagagctca tccgctcctt cacctgataa agcaaccgta acatgttttt ttgcttcttt 2787541 tgcaacaaag tacaacggaa tcgctgccgg atcagcaagc gggtcatcaa aatgccatac 2787601 gatcttcgga agctcattca tgtattcctc aggcgaaatg actttgctga tattttcaat 2787661 gcccagcgcc gctgccgttt ctttcgctac atcaacctca ctgaagccct gctgttcaaa 2787721 gccgacagag aatgttttta agcttggatg aaattccttc gcaacagaca caataaagga 2787781 agaatcaatc ccgccagaca ggaacgaacc gacaggaacg tcacttctca tatgaacgtt 2787841 tacagagtca tagatcgcgt ctcggacttc tttcacaagc ttgtcttctt cagtctgaac 2787901 cggcttgaag ttcgctttga aatacgtttt gaatgtgata tcgccgtccg ggcggattgt 2787961 gaattgtgaa cccggctcta cttttttcac atgggcatca agcgtgcttg gttcaggaac 2788021 aaattggaaa gacatgtact gctgcaatgc ctctttatct atttcaatat cattctgagc 2788081 aaccattaaa ctttttctct ctgaggcaaa ataaacctga tcattgatcg ttgtgtagta 2788141 caacggttta atgccgaatg gatctcttgc cccataaagc acatgatcgt ttttattcca 2788201 aatcagaaag gcaaacatac cgcgcagttt ggacgccgct tcttctttat agtgacggta 2788261 agtcgcaaga agaacctctg tgtccgaatc cgtgttgaat gtgtacccct ttgcttcaag 2788321 ttcttctctc agttcgatat agttatagat ttctccgtta aagataatcc aatatgtttc 2788381 atcttcatat gataaaggct gtccaccatt ttctacatca ataatgctga gccgtctgaa 2788441 tccgaagccg acgtgctcat catggaaata tccatcactg tcaggaccgc ggtgaacgat 2788501 catttggttc atttgtttga ttagttcttc ttgatcagcg gtttgagcta acggatgctt 2788561 gttaaaaacc ccgacaaatc cacacatagt attgcctcca taattaaaat tgtcatcatt 2788621 gaacccctat ttatagacgc tgtgaatagt atttggtttc acagttatgt aaaaaaataa 2788681 acatgaatac aacgataaaa aagggaaagc cgcttaacca gtaagcggct ataaaattat 2788741 tctcctaacg cttctttacg cagctgctcc gctttgtctg tgcgctccca tggaaggtca 2788801 acatcgtgac gtccaaagtg gccgtacgca gcagtttgtt tatagatcgg acggcgcaaa 2788861 tcaagcattt tgataatgcc ggcaggtcgt aaatcaaagt tattgcgaac aacttcaatc 2788921 agtttttcct cagaagcttt tcctgaaccg aatgtgttga ttgagattga cacaggctgt 2788981 gcaacaccga tcgcgtaagc aagctgtact tcgcaagaat cagcaagctc agccgcaacg 2789041 atgtttttcg caacgtatct tgccgcataa gctgcagaac ggtctacctt cgtcgcgtcc 2789101 ttacctgaga acgcgcctcc gccgtggcgt gcatagccgc cgtacgtatc aacgatgatt 2789161 ttgcgtcctg taagtcccgc atccccttga gggcctccga ttacgaaacg tcctgtaggg 2789221 ttgatgaaat attttgtttc ttcatcaatc agctcttcag gaacaaccgg attgattaca 2789281 tgttctttaa tgttgcgctg aatttgctca agtgtaattt cagggtgatg ctgagttgaa 2789341 ataacaatcg cgtcaatgcg gactggtttg ttattttcat cgtactcaac cgttacctgt 2789401 gttttgccgt cagggcgaag gtacggaaga atatcttctt tacggacttc acttaggcgg 2789461 cgggctaatt tatgggcaag tgaaattgga agaggcataa gctctttcgt ttcgttgcac 2789521 gcataaccga acattaatcc ttggtcaccc gcaccaatcg cttcaatttc ttcgtcgctc 2789581 attgtgcctt cacgggcttc aagcgcttgg tctacgccca tcgcgatatc agcagactgc 2789641 tcatcaattg atgttaaaac cgcacaagtt tccgcatcaa atccgtattt tgcacgtgtg 2789701 tatccgattt ctttaatggt ttggcgaacc gttttcggaa tgtcaacata cgtagaagtt 2789761 gtgatctctc cgcttacaag aaccaaacct gttgtcacag atgtttcaca agcaacacgc 2789821 gcgttagggt ctttctttaa aatttcatct aaaatgctgt cagaaatctg gtcacagatt 2789881 ttatccggat gcccctccgt aacagattct gatgtaaata aacgacgatt tttactcatg 2789941 atttgcttcc tcctgcacaa ggcctcccga aagaccttgt atatatgata cggaactcgc 2790001 tccctcttat acaatgtaca gttatattag agaatgttaa ttggcatatt tatgaaataa 2790061 aaaaaccttt tccatcgagg aaagggtttg gtctttgtgc ctttcactct tatcgctcaa 2790121 ggaatcatac aaccttgcaa caggttagca ccttggttgt ctcactcagt tgaacataat 2790181 aaataacaga gaaaccggtt gctgggcttc atagggcctg tccctccgcc agctcgggat 2790241 aagagtatcc gctcaatgaa atatcttatc gtaaaagggt ttgcaatgtc aatatgattc 2790301 agaagaaata ggcacctata ttgagggaaa acaatggaaa tgcacacaca aaaaacaata 2790361 aatagtatag actatttgaa aatatatgtt atactaattc acaattagca aaacacaaaa 2790421 aacgataaag gaaggtttca tatgaactca gttgatttga ccgctgattt acaagcctta 2790481 ttaacatgtc caaatgtgcg tcataattta tcagcagcac agctaacaga aaaagtcctc 2790541 tcccgaaacg aaggcatttt aacatccaca ggtgctgttc gcgcgacaac aggcgcttac 2790601 acaggacgct cacctaaaga taaattcatc gtggaggaag aaagcacgaa aaataagatc 2790661 gattggggcc cggtgaatca gccgatttca gaagaagcgt ttgagcggct gtacacgaaa 2790721 gttgtcagct atttaaagga gcgagatgaa ctgtttgttt tcgaaggatt tgccggagca 2790781 gacgagaaat acaggctgcc gatcactgtc gtaaatgagt tcgcatggca caatttattt 2790841 gcgcggcagc tgtttatccg tccggaagga aatgataaga aaacagttga gcagccgttc 2790901 accattcttt ctgctccgca tttcaaagcg gatccaaaaa cagacggcac tcattccgaa 2790961 acgtttatta ttgtctcttt cgaaaagcgg acaattttaa tcggcggaac tgagtatgcc 2791021 ggtgaaatga agaagtccat tttctccatt atgaatttcc tgctgcctga aagagatatt 2791081 ttatctatgc actgctccgc caatgtcggt gaaaaaggcg atgtcgccct tttcttcgga 2791141 ctgtcaggaa caggaaagac caccctgtcg gcagatgctg accgcaagct gatcggtgac 2791201 gatgaacatg gctggtctga tacaggcgtc tttaatattg aaggcggatg ctacgctaag 2791261 tgtattcatt taagcgagga aaaggagccg caaatcttta acgcgatccg cttcgggtct 2791321 gttctcgaaa atgtcgttgt ggatgaagat acacgcgaag ccaattatga tgattccttc 2791381 tatactgaaa acacgcgggc agcttacccg attcatatga ttaataacat cgtgactcca 2791441 agcatggccg gccatccgtc agccattgta tttttgacgg ctgatgcctt cggagtcctg 2791501 ccgccgatca gcaaactaac gaaggagcag gcgatgtacc attttttgag cggttacacg 2791561 agtaagcttg ccggaaccga acgtggtgtc acgtctcctg aaacgacgtt ttctacatgc 2791621 ttcggctcac cgttcctgcc gcttcctgct cacgtctatg ctgaaatgct cggcaaaaag 2791681 atcgatgaac acggcgcaga cgttttctta gtcaataccg gatggaccgg gggcggctac 2791741 ggcacaggcg aacgaatgaa gctttcttac actagagcaa tggtcaaagc agcgattgaa 2791801 ggcaaattag aggatgctga aatgataact gacgatattt tcggcctgca cattccggcc 2791861 catgttcctg gcgttcctga tcatatcctt cagcctgaaa acacgtggac caacaaggaa 2791921 gaatacaaag aaaaagcagt ctaccttgca aatgaattca aagagaactt taaaaagttc 2791981 gcacataccg atgccatcgc ccaggcaggc ggccctctcg tataaaaaac aaaagccaag 2792041 agcaattatg ctcttggctt gttttaattg acggaatgca aagaagtcag cttgtatgta 2792101 atgatggtcc ggccttcttc ccattgaagc ttctgcactt cagctgtgcc tgacttttcg 2792161 ccaaactttg ttttgcgtac atccattgga atctccatcg gatatactcg gtatccgtcc 2792221 ttctctaacg tgaatatatt ttcatctatg cgaacttctt ttccttttgt cacaatcagt 2792281 gtattaaatt caacaggcat tcccaaagtg aaatcccctt tcgttctctt ttttctttat 2792341 cataacatat ttcactgtca gcggtttttc atccattgtg tgagctgccg cacgatacgc 2792401 cggttttctt ttggcgggaa ataatgtgtg aatgtactgt agtaccatgt ttccaccggc 2792461 ttatgcagtt gttttagctt ctcttctaat aaataggaat gctgaatcga aacattttgg 2792521 tctttttctc catggattaa cagcacggga gcctgaattt tgtttacttg gtcaaacggt 2792581 gtcctccatt gatattcctc aggcaccttt ttcggtgttc cgccgatgac tcttttcatc 2792641 attcgccgca aatcctgccg ctcctcgtat gtaagaatca tatcactgac gcctccccag 2792701 gaaacaaatg aagctgcctg cccgcccatt tcgatcgcag tgagcattcc cataattccg 2792761 ccgcgggaaa aaccgaagat atggattcta tccttcttga catttgggtg ctgctgaagc 2792821 aggcgaaaag cagaaaatgc atcctccctg tcttctccgg caaaatcctc attgccttct 2792881 cctccttgat tgcctctgta aaaaggagca aacaccacaa acccttggga tgcaaactgg 2792941 ataatccggc ccggccgaac catgcccacg cttttaatcc cgccgcgcaa atataaaaat 2793001 ccgtcatatt gtcccggttc cgccggctca gccagaagcc ccttaacccg taatccattt 2793061 gacagatagc agatcgtata caaacgcaca tgctggcttg gcgacggaaa tcttcttttc 2793121 tctacaatca aaacagccgc ctcctttttt ctatatgctt tccttactcc aaaattacat 2793181 ccggagaacc tggttaggca ttcacacatt tttataccca tcatacgata tgtaaagcaa 2793241 aaaaggatat taacttgatg cgaaataagg aggttgtcta tgtgaacaga tggttaaggc 2793301 tgggcttcgc ctgtgtcggc agtatctttc tgatgttcgc cctggcggct tgcaagcagg 2793361 aagaaacgct caccaaagtc aaagtagctg aagtgaccca ttcaattttt tacgcacctt 2793421 tatatgttgc tgagtctaaa ggttttttta aggaagaagg gcttgatgtc gatgtgaata 2793481 cgacctgggg cggagataaa acgatgacat cgcttctttc caacggctcc gacatcgcgc 2793541 ttgtcgggtc agaaacatct atttatgtcg aagcgcaagg ggctaaagat cccgtcatta 2793601 atttcgccca gctgactcag acagacggaa cgtttcttgt cgcgagagaa gatgttgaac 2793661 acttcgactg ggatcagctg aaaggaaaaa cgtttctcgg tcagcgaaaa ggcggcatgc 2793721 cgcaaatggt cggcgagtat gtactgaaca aacataagat tgacccgcat aaggatatag 2793781 acctcatcca gaacatagac ttcgccaata ttgccaatgc gtttgcttct ggaaccggtg 2793841 agtatgtaca gctctttgaa ccgcaggctt ctctctttga gaaaaaaggc atcggccata 2793901 tcgtggcttc attcggagaa gaatcaggag aggttcctta tacgactttt atggcgaaac 2793961 aaagctattt gaagaaaaat gaagacacag ccgtcaagtt tacaaaagcc atttataagg 2794021 cgcagcagtg ggttgaaaat cattctgcga aggacatcac agatgccatt aaagatgaat 2794081 ttgatgatac cgacccagac gtcatcgaaa catccattga acgctataaa aaacagcatt 2794141 catattcacc agaccctctg cttaacgaaa aagaatggga gcttctccaa accattatgg 2794201 ataaatcggg agaactgccg aagcacattc catacaatca gcttgtaaat aaagaaattg 2794261 ctgaaaaagt cacctcggag aaataggagg cgccatctat gtctttctta catgtcgacc 2794321 atgtaaccca tacttatttt tctattaaag aaaaaacaac ggctgtgcgg gatattcatt 2794381 tcgatgccga aaaaggcgat ttcatctcat ttctcggccc aagcggctgc ggaaaaacaa 2794441 cattgctttc cattattgcc ggtttgattg agccatcaga aggcagagtt ctgattgaag 2794501 gccgtgagcc gaatcaaaaa gaacataata ttggctatat gcttcagcag gattacttat 2794561 ttccctggaa atctatcgag gaaaatgtgc ttctcggttt aaaaatcgcc gacacgctga 2794621 cagaagaaag caaagccgct gcactcggtc tattgccgga gttcggcctc atagatgtgg 2794681 agaaaaaata tccgaaagaa ctgtcaggcg ggatgcgcca gcgggctgcg cttgcaagaa 2794741 cacttgcgcc taaccctagt ctgcttttgc tggatgagcc attttccgcg cttgattttc 2794801 agacaaagct gtctttggaa aacctggtat tccgcacatt aaaggaatat caaaaaacag 2794861 cagtgcttgt cactcatgat ataggggaag cgatagcgat gagcgatacg atctttttat 2794921 tttcaaatca gccgggcacc atccatcaga tttttaccat tcctaaggaa ttggccgcga 2794981 tgttgccttt tgacgcccgt caggaacctt ccttccagac actgtttcaa acgatatgga 2795041 aggagctgaa ttctcttgag aaacagcaaa gaaaccattg atctgcttca cgagcagtat 2795101 caattcaaac agaaaaagga aaagtggaag gtccattcct ttcagcttgc catatttatt 2795161 ctctttttct cgggctggga aatctccagc aggcagggct ggatcgatcc gctgatcttc 2795221 agctctccat cagctgtgtg gcgattattg ctggagaaac ttggtgacgg ttctttactg 2795281 tcacacatcg gcgtcacttt atttgaaacg gtgcttggct ttttgctcgg gacgtttatg 2795341 ggcacgtgcc tagccgcttt gttatggtgg tctaaccgac ttgccagaat tttagatccg 2795401 tatcttgtga ttttgaacgc aatgccgaaa gtggccctgg gcccgatcct gattgtcgcg 2795461 ctcggtccca gttttatcag catcattgcg atgggagcca tcatcagcgt cattatcaca 2795521 accatcgttg tctacaccgc cttccaagag gtcgacgaaa actatacgaa agtcatgaaa 2795581 acattcggcg caaaaaagtg ggttattttt aaagaagtca tactgcctgc atcctccccc 2795641 gcgattattt caacactaaa agtgaacgtc ggtttatcat gggttggcgt tattgtaggg 2795701 gaattcctcg tttcgaaggt cggattagga tatatgatta tttacggatt ccaagtcttc 2795761 aattttacac tcgtcttctt aagcctgctg atcatcgcca tcttcgccac tctgatgtat 2795821 cagggcgtcg agctgctgga aaagaaatgg acgaagggga ggacataaaa aacccggcac 2795881 atgtgccggg ttttttattc aatccatcca gattctttca gttttttcaa gctgatcgga 2795941 agaacggaat ccttcataat aaagctgaat tttttattgc gggaaaggtt ctccggcagc 2796001 tcgtgaaaca aaaccgggcc tttcgtttca aagtaatcag cctgcttttc aagcttttct 2796061 atatctgcaa aatatatatt ttttacaatc actttttctt ttccgagaac tttatactgt 2796121 ccgagatact tgaggctttt gactctcgcg cccgtctctt cctttacttc ccggagcgca 2796181 gcctcttctg cgcactccat cggctctact ttcccgcctg gaaactcata gcctctgtcc 2796241 tcatgttctg ttaaaagcca tttgccgcca aaacggcaaa tcacccagac atgcttcggg 2796301 ctgtccgaga aaggctgatc gtcaaaggaa agctgaacag tattctgata ataatcttta 2796361 aactcgtaca tgtttatccc tcaaatccgt tcctagctat cttccataca tcataccaca 2796421 gttacgtttc ttcggaagcc ttttatcaaa aaataaggga aacccagcac gccgtcaggt 2796481 tctgcatgca gactagctcg tacagttttt ttgcgatact tttgccggaa agtgcgaccg 2796541 acgctctggg ctttattatg acccgcgaac agggaaaagt tacggtttgc gcttaaattt 2796601 attttttaac gtttctaaaa gatcgacaag catctgagga accggtatgc caagagagct 2796661 ggctgtcaca acaatttgca cagattcata aagaatataa aacataatag ccaagtcacg 2796721 aattgatccc tgtgtattca gcagctgatc aaaaaagtgg catacagaga tcagagccag 2796781 cgtgactaat tttttgacaa gccgggcaaa taccttttta aatgacagtt tgtgaataat 2796841 ggtttccttc aaagtcgtac tgataaattc aattgccata agagagagca aaatcagaaa 2796901 tgaatactga aaacctccaa agaaaaaacc cgctgctgaa acgctgactg ctaaaaacga 2796961 aaagatgcca aagtctctat ccatttatcc caacatcctt tcacagaaac ggccttacga 2797021 tattctatgg taaacaagcc gaacggattg gatttttcag aaaaatggac tggttgtcgc 2797081 ctatttttca gatacaaaaa gaaaagccgg acgtcttttt taagacatcc ggccgttcta 2797141 tttttgaact taacctaggt aagcttttag catccagtta tgtttttcaa tattttgatg 2797201 gatcgcaaga agcatgtccc ctgttgtttc gtcaccgact tcatcagcta aatccatgcc 2797261 gtttttcagc tcttccgcga tgactgtgaa atcatcatat acgctttgaa ccatttgttc 2797321 agctgtttca tttccagcag cttctttgac agaagccgtt tctaaggatt ccttcattgt 2797381 tgcaatcggt tttccgttca gcgccaaaag acgttctgct aagtcatcaa tataagttgc 2797441 tgtttcgttg tacagctcct caaacttttc atgaagagtg aagaaatctt tccctttcac 2797501 ataccagtga taattatgta gtttcacata catgaccgtc cagttggcta cttgtttgtt 2797561 cactgcttga atcaattgtt ctgacatggt atctcctcct tgttatatga ctatgtatac 2797621 ccttaatatc gtacgctaaa acctcttttt tacccttatc tgtcacgatt tcttctatta 2797681 tgctacaatt gttaaaaaac gggaggtgga atgtcatgac gcttctcatt acgataagta 2797741 ttttgattgt gctggctgtt ttgcttgtaa ccatttggac gactgtaaaa gcctataatg 2797801 taaagcatac cattgatcca ccacaagaaa atcactctga ttcacacaat caatgatgat 2797861 gtgaatgctc ctcttctgac tgattgctgg cagcatcggc gtctccgact tggactttta 2797921 aggtcggcat gctatgctgt ttttttgctg tgacatgaga ttggacagtg tatacaccat 2797981 cttccttaaa cgtcgtttcc aatcggtata cgcctttttc ttgtttcacc ttaaacattt 2798041 ggcttgcgtc tttttcccct tctttccata cttcaaactc tacttcatcg gcatccgtca 2798101 cagcttcatc accatatgat acagctgctt cataagcagc gctttctccg ggatttactt 2798161 tttcaggccc ggtcagcttg acatccaaaa cctcgggcgt ctcagctgta tttgctttac 2798221 tttcaccaga tccgcatcca ttaagcaata aagcagaaaa aagcagaaca accaacatct 2798281 ttttcatgcc atcacccttt catcgtttac ctaaatagta gcaaacgctt acagcaaatg 2798341 gtacacaaaa tatgagacgt cacaaaaaag acctttttgc ttaagcgcaa aaaggtcctt 2798401 tctattttag ccaaatactt ttagcaattc ttctttatcc tgtgaaagcc agaaacgcat 2798461 taaacgttta gcgccttcca gatcatgaag cttcgcttgg ccgcactgct tttcattcgc 2798521 agcaggtatt tctgtaatct ctaccgcttc cttcattgtg tcttcaagca gatcaacgat 2798581 ttccgctgat gtcggctctc cgctcacaac tagataatag cctgtctggc agcccattgg 2798641 agaaatatca atgatatcaa aatgatcgta tttctcagcg tgagaacgaa tcgtaaacgc 2798701 gagcaaatgc tcgagtgtgt gaatggtgtc aggcttcatc gcctgtttat ttggctggca 2798761 aaaacgaatg tcaaatttat ttacaacgcc gtctgttccc actttatgca cgccgcaatg 2798821 tcttacatat ggagcaacaa ccgcattatg atcaagctca aaactttcta ctgaaggcat 2798881 aatggcactc tccccttttt taaaaatgta atttcattat aacatacttt tccgataaga 2798941 attattgatt aacttttcaa tctgtgtttt ttttcttata cttgcatcag aaaggttgct 2799001 gaagaaacat gaaaacccta ttcatcgctc tgatcagagg atatcaaaaa ttcatctcgc 2799061 ccctgacacc gccaacgtgc cgcttttatc cgacctgttc ccaatatgga atcgaagcga 2799121 ttaaaacaca tggcgcttta aaaggcggat ggctgacaat caaacggatt ttgaaatgcc 2799181 acccgttcca tccgggagga gtcgatcccg ttcctgaaaa gaaacaaaaa cattaattgt 2799241 tataaccgtt tacgataaga tccagttttc cggttttagg atcaatgact aagccatgga 2799301 ccggaacgtt ttcagggaac agcgggtgat gtttaataac atctacgctg tctttcacac 2799361 tcgcttccac tgaatcaaag cttttaaacc attgatcaaa gtctacaccg gagtacttta 2799421 ttgtttcgat gcgttcttcc ggaatccctc ttgctttgat tttttcaagc atgcttttgc 2799481 tgctgatttt gctcatgccg caatcgtgat gcccgatcac acacacctca tctgcattca 2799541 gctcgtacac tgcgacgagt atacttctca tgatgcttcc gaatgggtgt gtcacaagcg 2799601 caccggcact tttaatgatt ttcacatcac cgtttcgcaa attcatcgca tgcggcagca 2799661 gttcaaccag acgagtatcc atgcaagaaa gaatcgccat ttttttatct ggaaattttg 2799721 atgtttgata cttttcatac tctctttgtt cagtaaatgt cttgttaaat tcgagaatat 2799781 catttagaag actcatgttc gttgtccctt tctattcttt ttactcttca atatatcaca 2799841 acccttgttt attcgtcata ataaaaaaag acaaaccctc aggcctgcct tatttcccca 2799901 tgttatagcg ttttttgaac tgctcaactc gtccgccttt ttcattgaat ttctggcggc 2799961 ctgtataaaa cggatgcgtg tcagagctta cctctacttt aatgacagga tatgtgtttc 2800021 cgtcctccca ctctgctgtt tcattagatg ttttcgtaga ggtgcttaga aaacggtagc 2800081 cgctgttgac atcctgaaat atcactttgt ggttctttgg atgaattcct tctttcatgg 2800141 gtatctcctt tcaataaatc gtaataatta cgttttattt tataacctta caaacgtttt 2800201 gtcaatcttc ttatatcctt ccctctgttt cacatcgtaa acctcatggc atttaagaat 2800261 aggaagaata atctaaccga ggaagcaaat aataaaccca aaatacatac agaacgtctt 2800321 tttggaaagg tggtttacga ttgtggatga tttagttttg gccagaagcc tttttggcac 2800381 gacgatgggc tttcatatca ttttcgcaac acttggagtc ggtctgccgc tcatgatttt 2800441 agtggcggaa ttgatctatc aaaaaacgaa agatgaccat tatgcgatca tggcgaaaag 2800501 atggacgaaa gcacaagccg ttttgctggg ggtcgccata ccgaccggaa cgatcgcggg 2800561 cactcagctc gcgcttttat ggccgggatt tatggaagtc atcggccggg tgatgtccct 2800621 gccatttcaa attgaaatct atgctttttt tgttgaagcc ctattcatgt cgatttatgt 2800681 atacgctgca gaccgtttgt cacctgcaat gaggattgtt gctgttttct ttgtgttagt 2800741 cggggcagca gcatccgctg ttctgatcac gaatgttcac gcttttgaag gtacgcccgc 2800801 cggttttaaa attttaaacg gaaaaattac agatgttgac ccgtgggctg cgttttttaa 2800861 tcctagcttt tttatcactg ccggccatgt cgtgctgtcc gcgtttatga ctggtgcgtt 2800921 tatcgtggct tctgttgcgg cgtataaaat gatccgaacg aggaaaaagg aaagggtcta 2800981 tcgctttcac cggaaagccc ttttgctcgc actgacgatc ggcggtattt tttcattgct 2801041 gaccgctttg aacggacacg aatctgcaca gatgctgtac gaataccagc ccgaaaaatt 2801101 agccggtgcg gaaggcctat ttgaaacaag atcccacgcc ccgctcgcta tcggcggttt 2801161 taccgacccg aatgaagaaa aagtaaaatg ggcaatcgag attccatggg ctttaagctt 2801221 tttggcagcg aaccgttttg acactgttgt aaaaggatta aatgcatttc cgagagatga 2801281 atggccgccg cttttcattc acacgctgtt taatgcgatg gttggtgtag gcatgctgct 2801341 aattctttat tccattatcg gtgtggtctg gagaaaggtg ctcaagaaag accgtttccc 2801401 aacgtggctt ttgatcattt tcatgacagc aggccctttt agtctcatcg gcattgaatt 2801461 cggctggatt ttcgcatgta cggggaggca gccttgggtc atctatcatc tgctgaaaac 2801521 gtcagatgtc gtaacaacga ctggctcgat cggggtgctg ttcttatttt tcacatttgt 2801581 ttatgccgtg ttaggcgcag ctgtcgtcta cgtgctgctg tattatttcc gcaagcaccc 2801641 ggttgacgaa gatttaaata cagcggagtc gtaatggctc cgcaaacagg aaaccaaatg 2801701 gaaggaagat cgtacaaatg gagatttcaa ctgacgctct gatcgccatc tcaattatct 2801761 ggggctttgt gtttatttac gccgtcatgg cgacaatgga ttttggagcg ggattttggt 2801821 ctatgatcta tttaaacaag gagcatatga aggccaccga tattgcgaat cgctttttgt 2801881 ccccgacttg ggaggtcaca aacgtcttta ttgtggccat cgtcgtggcg cttttcagtt 2801941 ttttccccgg cgcgacattt gtgctcggca ccgttttatt aattcccgga agcatgattt 2802001 tgctgctttt agcaattcga agcggatttc tcgtgttttc aaatacagca aaggagcgga 2802061 aaacgctaag atatatttcc ggcatctccg gctttatcat tcctgctatt ttaattttgg 2802121 tgcttcctgt gacacacgga gggtttatag aaaaaacgga tggaatctat aacttaaata 2802181 tgtctaaaat cttttcaagc cccaacgcct attcatttat cgggtttgcg attttaagca 2802241 ccttattttt gtcctcgctg ttgcttgcag atttttcaaa tgtggcagag gaacaggatg 2802301 cgtaccgagc ctacagaaaa agcgccctga ttaccggccc gatttcactg ttgtttgctg 2802361 tatgcattat ggtaactatg cggaatgaag caaactggct gtacagcgga atgatgaatg 2802421 atttttcttg gattattgca tcgttcatta catttgtcat tgctggaatc gctctttttc 2802481 tgcctaacaa aagctttggt caaaacatcg gaaaaccgcg tctcgcactt gttgcgattg 2802541 ggatacagta ttttctcgca agctacgcgt acgggcgggc gcatcttccg tatatgattt 2802601 atcccgatgt gacagtcatg tcaggcttca cagagccagc aacgttcaga gcgctgtttg 2802661 caacgtatat cgttgcattt atcattctat ttccgggctt ctttttcttc tggaaaatgt 2802721 ttatgcgaga taaacgctat atccgccagg aggaatagag ggcaagccag ccggctatac 2802781 taatccagaa cctttataag gaggggatgg catggagcag aaaattctat gtgaggtcaa 2802841 caactgttct tattggggca aaggtaacaa atgcaccgct gatgccattt atgttgtcag 2802901 ccatactggt gaaacggctg aaaacagccg ggaaacagac tgcaaaacgt ttaagccgca 2802961 tgatttataa ttaaaagaaa gagctgcatc agccagctct ttctttttgc atgttgagtg 2803021 ttctcagctt tttagttatg accccgtttg caggtgaaaa caaaaaggcg cttgcataac 2803081 atacacctgt catggccgcc atcgctcctg aaatcgaaac attaagccac gttgcgaaga 2803141 aatagcccat gaccgccgac agcccgccaa tcaacgcgct gagaatcagc atataaagaa 2803201 gccggtctgt cagcaaatgt gccgcagccg gcggaacaat cagcatggcc acaaccaata 2803261 cggcacccac cgaatcaaag gaagcaacag tcgtcaagga cagcatgccc atttgcacgt 2803321 aatgaatgag caaaaccggt attcccaagg ctaaagccat ttgaggatca aacgaagcga 2803381 ttttaaactc cttatagcac acactgatca acactacgtt taaaaccaga acagatgcca 2803441 gcatccaaaa cgctttcggc ccaatatcaa ccccgaatac cgtcaccgta ttccacggca 2803501 caaaagcgat ttctcccatt aacgagtgct caatatcgag atggacattc gctccataca 2803561 cagaaagcaa aataaccccg attgcaaata aggatgtaaa cacaactcct atggcagcat 2803621 ctgattgaac ccccttgcta tgaagaagct gaaccaagaa agccgttaac agaccggttg 2803681 cggctgcgcc aataaacata taaatcccat cgagacttcc cgtcactaga aaagcgccga 2803741 caatgccaag caacactgtg tgactgattg cgtcggccag catcgccatg cttctcagca 2803801 caagaaatgt gccgatcaat ccgcagctta caccgactaa tacaccggta gctataatcc 2803861 atgcttcaaa actcatttgc gatctgtccc ttctcggcat catgagacgc ttttcgacgc 2803921 tcaggcatcc gtccatacag ctttaagagt gaataaagcc gctctctcgt ttctctcggt 2803981 aaacggtccg ggtcaaagta gtcctgatcg gattctatat tggcaagttc catttcatgc 2804041 atgagataca cttcatacat ccgctgcttc aaagctgtgt gatagccttt ttctatccct 2804101 ttgcttgtga tttgccaaat cccattttcg atacgctcaa tgcacctctc ttgttccaag 2804161 tcatttaatg ccttaaggca taatgaaggg gataggcgtc ttttctttct tacactttca 2804221 acagttacac aaagattatt cttttcatac tgttcataaa tcgccaaaag cacttgctcc 2804281 ctgcttgttc tgcgccgcag cctcatcagc cttatggctt tagcagccaa tccccgctta 2804341 ggcgcgcaaa tcattgaaaa aagaaagagc agcgttgcag ataagatcat taatggccct 2804401 gtcgccattc ccttcatcgt ggtgctaagc agggttccgg ccactccgct gaccccgcct 2804461 gtaatcccgg caatgatgat catcccggtt aatcgttcgg tccaatatct cgcggttatg 2804521 gcaggtgtaa tcagcatagc cgccattaat atcacaccaa cagtctgaag cccaatgacg 2804581 acagcacaga caatcagaca agccaaaagc ccgtttaaaa aacgcaccgg gattcctaat 2804641 ccctttgcaa acgcgagatc aaaagtaatc aatgtaaatt ccttaaagaa aacaatacat 2804701 aggagcagta gaacagcgga tatccctgca ataaggatga tatcctgcct gaccaatgaa 2804761 gcagcctggc cgaataaaaa agaatcaagc ccgctttggc ttcccgcccc ctgttgctga 2804821 atatatgtca gcagaatgat cccgacgcca aaaaacacag aaagaacaat cccgatcgcc 2804881 gagtcctcct ttgtttttga aagccgagga atcagctgaa tacaaaacgt tccgagcagt 2804941 ccggcgagcg ctgcccccag caaaaagaaa ggcagtgatt tttgcccggt gaacagaaaa 2805001 gcgagacaca ctcccggcag agctgaatgg gccatcgcat cgccgattaa actttgcttt 2805061 ctcagcagca caaagctgcc caaaacaccg cttgccgtcc cgagcaaaag cgtaccggcc 2805121 agcacccact gtgtattcgg atgctgaagc tgcagccaca aactttcaaa cattgcgctc 2805181 actccttatg tccttctgcc agcactttat cttttaaaaa cgtaagcctt cctccatatg 2805241 ttttttgcag gttttcgatc gtaaaaacgt tttccgtcgg tccgaaagcg attttcctta 2805301 aatgaagcag taagatccaa tcgaaataat cctcggcggt ctgcagatca tgatggacga 2805361 caagcacggt ttttcctttt tctttgagtt ctgccaacag cgtcataatc gcgcgctccg 2805421 tcgctgcatc aacacctgca aacggttcat ccataaaata aatgtcagcg ttctggcaga 2805481 gtgcccgggc aagaaacacc cgctgctgct gtccgcctga cagctggctg atttgccttt 2805541 tcgcataatc atgcatcccg acttttgtta atgcggcctt cgccatctcc acatccgctt 2805601 tctttggcct ctttaataaa ccgattctcc cgtatcttcc cattaggacg acatcgagcg 2805661 ggcttgtggg gaaatcccag tcaaccgagc cgcgctgcgg aacatatccg attctggtcc 2805721 gctgatcctt atagtctttg ccgtaaatag agatgtctcc ggaagctctg ggcacaagac 2805781 cgagaatcgt tttgatcaag gttgattttc ccgcgccgtt tgggccgata atgccaataa 2805841 gttttccttc aggcacctgc agcgaaatgt cctgcagtac aggcttttta tgataagcaa 2805901 ccgtcacatt atcaagctca acagggaaca tatcctccac ctcttttctt tatttaagcg 2805961 ctttagtaat cgtgttgata ttgtggcgga acattccttc gtatgtgcct tcttttgtgc 2806021 ccttttcacc catggcatcc gaataaagct gaccgccgat tgtgactgta tggccttttt 2806081 ctttagcgcc ttccaccact gcattgattg atttttcaga tacactgctt tctacgaaca 2806141 cagcttttat ttgtttttct gtcagaagat caaccagctc ctgaacatcc cttaatccat 2806201 agtccgaatc tgtgctgagt ccctgcaggc cttttacctt aaatccatac tcattcccaa 2806261 agtacgcaaa cgcatcatga gcagtcacaa gcacacggct tttctccgga atatgtgcga 2806321 tctccttacg cgaccactta tctaaatatt gcaaatcttc tttgtactct ttggcatttt 2806381 tccgaaaggc atctgcgtgc tgaggcattg ctttgctgaa ttgcgcttca atttcatcca 2806441 ccgcatagat ccataacgga atgctgaacc agacgtgggg atcaaacgtc ttgccttccc 2806501 ccgcgggaat aagcttattt ttcggaatgg cctcagctac tgccgccgat tgtttttgtt 2806561 cgccgatttt ttggaggaca tcctccattt tcccttccaa atgcaacccg ctgtacagaa 2806621 caacatcggc agacattaat tttttcgtgt caccttggga agctttgtaa aggtgcggat 2806681 caacccccgg tcccattaaa gaggtgactt ttacgtgctt acctccgatg ttttctgctg 2806741 catcggcaat ttgagatgtt gtcgctgtca cttgtaattg ctgatcagcg ctttttccgg 2806801 ctgaatccgt tccgcatccc gttaaagcaa aggtcgcaaa aagtactgct gccatcagcc 2806861 cttgtctcat atttctcctc ctctttgcca tcaatgtccg attgttttat cttatgttgt 2806921 cagttcttag acatgtgaca ttaaattagc caaaagcatg ttttatttac acaggacaaa 2806981 aagtttccct catgcaaaat tatcgcgttt ggccattttt gtcaagctga tttacataaa 2807041 aaaaccggct gggtcagcag ccggtccaaa cgagaaggga tgtattcaac gaacactttt 2807101 actgtaacag cacagtgtca tttattcaaa atagcaaaat gcttttttct taaccatgct 2807161 gtgtgaaaac atccattttg gtcacatatt ttcgcataat atcttggttt acctcaaccc 2807221 ctaaaccagg ctgttttgac acagaaataa atccattatc aatacgaata tcaggagtta 2807281 caatatcttc atcccaatag cgtgaggatg aagatatatc gccaggtatt gtgaattgag 2807341 gcagtgaagc aagcgccacg ttctgcgctc ttgatatgcc tgtttccagc attcctccgc 2807401 accaaacctg catatgatgc tctttgcata aatcatgaat ttttaaggct tctgttaagc 2807461 cgccgacacg agaaggtttt atattaataa ttttgcagct tcctagctca atcgcccgtc 2807521 tcgcatcatc aactgaacaa atgctctcat caaggcaaat ggccgttttc aaatgtttct 2807581 gcaagtggcg gtggtcaacg atatcgtcag cttggagcgg ctgctcaatc atcattaaat 2807641 gatagtcatc aagctccttt aaacggctga tatccttcag ttcgtaagag gaattggcat 2807701 cggccataag cgggatggtt gggaatcggc tgcggatggc cttgaccaat tccacatcct 2807761 gcccaggctg aattttaatt tttattcttt gataaccttc tttttgatag ctctcaattt 2807821 ccttcagcat atcgtcaaga ggcgccaggc cgactaccac cccggcaggg actttatctc 2807881 ttgttccgcc caatgcctca gcaagggata cgcccttctt tttggcataa atatcccata 2807941 cagccgattc aagtcccgct tttgccatcc ggtttccttt ataccgcgcc aggctgtccg 2808001 gcacttctga agggtgattg aattcacggc cgacgacatt tgggataaaa aaatctttta 2808061 gcatatgcaa acatgttcca atggtttcct cggtgtacca aggcgaagag aaagcggaaa 2808121 cttctcccca gcctgtgaca cctgatgtat caatggcttc cacgatcaga aatttacgct 2808181 cttgaagcgt ttcgatactg tttttaaacg gtttctttaa gttcatgctc aaatggtaaa 2808241 gcgtgatttt ttctatttcg atcatagcag ttctccttta cgcgcatcct tcagctgatt 2808301 tcgcaagagc ttattagacg cattgcgcgg caggcggtca agcacaaaga attttgccgg 2808361 aattttatac ttcgccaagc gttctttgca gtagtcagtc aattctcctg cgctcacagg 2808421 cttgtgaagg acaagatagg cgtgaggcac tttcccccat tttttgtcct cagcccctga 2808481 aaccccggct tcggccacag cggggtgtga aagcagcact gactccactt cggccggata 2808541 aatgttttct ccgccggata tgatcagatc tgaacgtctg tctaatacat ataaaaagcc 2808601 ttcattgtcc aaataaccaa gatcacctgt tttcagccag ccattttgaa aggaggcttc 2808661 gtttgcgctc tcccggttaa aatagctttt catgacattc gggcctttga ccatgatttc 2808721 accgtgttca tacggttcac atacctgtcc gtcccgctct attttgattt cacacgaaaa 2808781 cagcggtttc cccgcagatc cgagcttttc catgctgaat tccggcgaca gggtaacaat 2808841 ttgcgagcat gtttctgtca ttccatatga ctgaaagaca gggaatcctt tctcacggca 2808901 ttcctcaagc aatggcagcg gtgcaggacc gccgccgaga agaatgcatc tgatggattc 2808961 agggcagcgg tttgtttctt ccaaaagact ggccagcata gtctgcaccg cagatatcat 2809021 tgtcacttca tgcctgttga tagaatgcag cacatcgctt acggaaaaac gctggtgaag 2809081 cacgacagtc attccataga tcacagattt aaataatgcg gacaatccgc tgatatgaaa 2809141 gagcggcaat gcgataagcc agcggtcttg ttctgttata cccaaattaa gagcggacga 2809201 caccgcactg aaataatggt ttccgaacgt ttgctgaact cccttgggct ttcctgtcgt 2809261 acccgacgta tacatcagcg ttgccgttgc atccatttgc atataagcct cgatctcaat 2809321 ttcctctgct gcttctttca tcagttcatc cacatcaatc gtttgaacga tgtgttcata 2809381 ttctttcttc tcaaagcttg aatctgtcaa taaaaagccg gatcccgaat cctccagctg 2809441 aaacagcctt tcatgtgttg acagcttcgt attcaaaagc accgccttaa caccaagcaa 2809501 aaaacaagcg tgaacagcgt ataccatttc tgcacggttt tggagcaaaa tagctgcagt 2809561 atcccctttc cgaaccgaat gagcggcaag ctgttccgcc attcgtttag acgcggcaaa 2809621 caattctgca aatgtcacgg tttggtcttc atagatgaga gcgattctct caggtgtcag 2809681 ctgtgcccgc tgcatgagcc agttgggctg ttctgtcagc atgtcatcat ctccgaggta 2809741 aaatgtctgt attgaaaaga aaacagcttg gaccgcaaag tctcaagctg ttggtttact 2809801 agatattgct gatcacggaa aacgagggaa ctgtccgaaa tcaggtttgc gtttttcctt 2809861 aaaggaatca cggccttctt ttgcttcatc tgttgtgtag taaagaaggg tagcatcccc 2809921 tgcaaactgc tgaattccag caagtccgtc tgtgtccgcg ttaaacgcag ctttaagaaa 2809981 gcgcagtgcg gtcgggcttt tttcaagcat ttcttcacac catttaatcg tttcttcttc 2810041 aagctgttcc aaaggaacga ctgtgttgac aagacccatg tccagtgctt cctgtgcgtt 2810101 gtactgacgg cataggtacc agatttcacg tgctttttta tgtcctacaa ttcgagccag 2810161 gtagccagaa ccgtaacctg catcgaagct tcccacttta gggcctgttt gtccaaaaat 2810221 tgcgttgtcc gcagcaattg tcaagtcaca tacgatgtga agcacatggc ctccgccgat 2810281 cgcatatccg gacaccatcg caacaaccgg tttcgggatg acgcggatta aacgctgaag 2810341 atccaatacg ttaagacgag ggatctggtc gtctcctaca tatccaccgt ggccgcgcac 2810401 tttttggtct ccgccagaac aaaatgcttt gtcccctgca ccggcaagca cgataacccc 2810461 aacgttttgg tcgtctcttg cgtcagcaaa cgcatcaatc atttcagcaa ccgttttagg 2810521 ggtaaacgca ttatgtacct caggtcggtt gattgttatt tttgcaatgc cattatacgt 2810581 ttcatacaat atctcatcgt atgtccgttt tgttttccat tcagccatat gatgacctcc 2810641 ttttattctc tatgtgaatg agtcagatgc ttgtcaaaaa ctcactcact attttaccaa 2810701 acaatcgcgg ctgctccaca tggaccgtat gtcctgcttt tggaacaatc tctattctac 2810761 tagaaggaag catcttatgc acctcttgat tgatggcgca aaatttttcg tcccactccc 2810821 cgcagatcag aagcacagga acatctattt cctctacacg gctccacaag gaaggctgtg 2810881 aaccggtgcc catgccggtt aaactgttcg caagcccaat cttattgttc cgcagacggc 2810941 ccgatcgtat cctgtaccga atatcttcag ccagcctctg ctgagatgaa aacaaaggga 2811001 tattctccca atacgcaaca aacgcttcga gcccgtctcg taaaataaaa tcagcaagct 2811061 tccggtcccg catgattcgt tcccgccgtt ccccaagtgt tttgagcccc ggcgtcgtgc 2811121 tttcaagcac aagtgccgat acccgctcgg gatatgtcat cgcaaaagag taagcaagcc 2811181 ttcctcccat agaataccca atcaatttca ctttgtgaag ttttaattga tcaaaaatct 2811241 cggcaaggtc agaaacttgc cgggttgtgc tgtatctttt cccattcagc ggggcatcgg 2811301 tttccccatg ccctaaacaa tcaattttga tcaaacggga atcaggcagc atttcatcaa 2811361 gaaaagtcca tgattgtttg ctgccggtaa acccatgcag acagacgacg gcttcggaag 2811421 cattcggtcc ctcgtctgcc actgcatatc ggacaccatc tgataccgtt atgtttacag 2811481 ttcccattgt tttttcactt cccgcacagc ctcattcagc atatcgcgat gaagctggac 2811541 tcttgattgg cgatccgttt tgatttcaat caaatggagt ccgggcttgt ctgcctgcgg 2811601 cgcgtaagct gttttgaatt catcccaaga agccgggcat gaatacgttc cgccgtaaag 2811661 tgcagccgca tgcttgaaat cgagccctgt cggtgtgccg aacaaatctt caaagtgtgt 2811721 cttctcagaa gcctgcggca aaaaggagaa aatccctcct ccgtcattat tgacaagaat 2811781 cacagtaaga ggaataccca gctttttggc cgccagcagg ccgtttaaat catgataaaa 2811841 agataaatct ccaatcacaa gggtaacagg cgcttttgtt ccttcacata cccccatggc 2811901 agaggagacg acaccgtcta tcccgtttgc tccccggttt gaataaatcc ggaaagggcg 2811961 gtcctgcttt tcaaaaaacg tatcaacatc cctgatcggc atgctgtttc ccacaaacag 2812021 cgagctgttt tcaggcacaa gatgctgaag gattcgatag agattgcctt caaacgaaac 2812081 atcttcactg ctgattgttt gcagatgctc gcggaaccgc ccattgacaa actgccactt 2812141 ttccagccac tctgaggatc tggtggcagc agtaaggcct gccatgatct cctcagcaaa 2812201 aacagacgca ttacaatgaa tcatatgcgc gcttgcctgt gtcgggtctc tccaccctcc 2812261 atcctcgtca atcacgattt gctgaatcgt cggatcatcc ttaagccata agaaaaccgg 2812321 ttttgaaaca ggcatcggtc caaaccgaat gacaacatca ggacggagtt tccgcttcag 2812381 ctcatcatct tttaaaaacg aatcatacgc atcaataaca gtgcttttat catgaacacc 2812441 attccgcaga ttagacagcg gatctgctaa aattggatac tgaagcgctt ttgacagcgc 2812501 aataatgttt tccttgtccg catcactatg gagctctccg cagacgatca ttcctttttc 2812561 agcctctgcg agcatctcag ccacatcaga cagggactct cggtcaacag actgcgtacc 2812621 cgttttcaca gacacatgac ggcctgttct cattcttcca aacggctcat ctgaaagatc 2812681 cggcatcagc ggttcgcgca gcggcacatt cacatggaca ggccccatcg ggcgcttttg 2812741 tgcttctccg gcagcgcggc ttgccagcgt tcggatgtat ctcagcattt gcggagactc 2812801 ttcaggaaga gcagagtctg tgaaaaactt aacaaagtta ccgaataaga agtgctgatt 2812861 aatagcctgc ggtgcgccta cttcgcgcag ctcatgaggc cgatcagcag ttaacacaat 2812921 aataggcacc cttgaataat gggcttcaac cacagccgga taaaagttgg ccgcggctgt 2812981 tccagatgta cagatcaata gtacgggacg ctgcttcgct tttgccaaac ctaatgcaaa 2813041 aaatccggca gacctttcat caatttggac atggacgctg atatcgggat gcgcagcaca 2813101 aagaacagcc agcggtgtag atcttgagcc cggacaaacg acggcgtccg taattccgga 2813161 aagggcgaat tcatcaataa aacttccgat gtaatgagta atcgggttga ctgtcaacgc 2813221 ctctcacctc ctaatgcaga gatcatcggc ttcaatttaa tctgtgtttc ttcatattcc 2813281 gagattggtt ccgagtcttc cacaataccg cacccggcaa acagccttgc tgtgcttcct 2813341 tcgatgagcc ctgaacgaat ggcgaccgcg aattccccgt tatcctggct gtcaatccag 2813401 ccgatagggg ccgcatacca gccgcgggac atcggttcaa tctccctgat cacgtcaaca 2813461 gctttttcct gaggtgatcc cccaagcgcg ggagtggggt gcagcttctc aattaagtca 2813521 aaaatcgaag cagactcgcg cagctgtccg acaatcggcg taaacaggtg ctgaacgctt 2813581 tttgttttgt acaaaacagg tccatcaggc ttttcaacct ctgaacagct tgatacaaaa 2813641 gcattatgaa tcatacctac cacaatatca tgctcaagca ggtttttctc atcgtttaat 2813701 aattcaaggc ctatccggcg gtcgtcttct tcattcacgc ctcgtttaat ggagcctgcc 2813761 agacaggaag acatgacagt gccgccgtct cttttgatca gtctttccgg agacgcgccg 2813821 acaaaggttt tgccttcttg ttcaattgca aaaacatagc ttgtctgctg atcgtccaga 2813881 agcgttttaa gcaccggttc aatttggatt ggaccgtcaa acgtgagcag cagctctcgg 2813941 gcaagaacaa ccttatcata ttgtttctct ttaatttggc ttgtggccgt ttcgattgct 2814001 ttcagccaat catccttatc cagctcttcg gctgctgcaa tcacagcctg atcttcttgc 2814061 ttgaaatcgg gaaccataaa ttccgccgca aaagctttta agccttctaa aacagcttct 2814121 gcgtcttctc ctccgcttac ccatctgtta actgttaaga acgggccttc agcagtcatc 2814181 gtcagcataa gcgcaggcac aaagaaatcc ccttccgaga aatggtccca ttgtgaacct 2814241 ctttcttcgc aagggtcaaa agaaaatcct ccgaataaca caggtcccac tgcagaatgc 2814301 tgcagctttt cttcttcata aatatgaaaa gccgtctttt taaagcgctc ccattgttca 2814361 aaaacctcac gataccgctc gctgtttttt tgatttgtct ggaaaaccgc ttctttgcca 2814421 agaccgacta ttgtcaattc actttcagga tctgaccaaa aaaatcgatt gcctgtatat 2814481 ttttttgctc cgtaattgaa aaatgataga gggtcaagag actcgatttg tctcgaatag 2814541 cttattaaga cagcatggtt gacttctttg gctttatgta atgcatgtag aacttccttt 2814601 cggaacgtac gctgcaccgt tgtcaccatg agacattcct ccataatcct taaaatgctt 2814661 ttaataccat acacctgtgt ctcctttgtg tcaaacacag atcatgcagt ccaaatggcc 2814721 tgccttacct attataaacc taatttcaga aatgaaaaag aaacaaagct taaatttctt 2814781 tctccactga tagcaaaggt tgtatccgct taccataaaa ggaaaacctc ctatattcct 2814841 ccacccgcca tttatgaaag ttctcaggcg atctgttcat actaaaggta tgcatcacag 2814901 agaaacgagg cgatcacatt gcttacgaaa gaacagcttc agcatttaaa aaatgaactg 2814961 gaacaaacga aaaaagatat cttaaaccgt ttcaaagaca atgatcattt tcagcttaac 2815021 tcagcctttc cttatgattc gtggggtgag ctttcggcat acgacaacca tcccggcgat 2815081 caggcgacag aactttacga gcgtgagaaa gacatcgctc tagacttgca tgagagagag 2815141 caccttcggg acattgagca ttcattgaag gcgatagaaa acggtacgta tggcatttgt 2815201 gaagtcagcg gaaaggaaat ccctttcgaa cgacttgaag cgcttccgac tgccacaacc 2815261 ctcgcggagt attcgtcaca ggacgtggtt tccaaagacc gtccgattga agaagaaaca 2815321 ccattcgggc aatttgaatt tgatgatgat gaagaaatca gagcgccata tgacagtgag 2815381 gattcctatc aggatgtcga aaaatatggg aactcacaaa cgccgcagga tatggaaaac 2815441 cctccgctca gctatgatga tatgacgatg aatgccgaag agaatatcgg caatacggag 2815501 tcttacgaaa atttcatcgc tacagatatc actgggaaag aaattaccgt ttatcaaagc 2815561 agagcccatg agcgctatga agaagaactt gacgaagagg gaatcatgac cacattcggc 2815621 gatctccacg ctgattgaac ccccaattat tgggggttct tttccgtttt cagcatatcg 2815681 taaatcagct tcagataatc cttttgcagg ccgatgtcat accgctcgcc ctctagcaat 2815741 ttcccgtata cggtacatgc cccgagcgaa gcttttatcg catccgttac ctgcacttct 2815801 cctccgctat cagcttctaa tgcctccagc tcattaaaaa tatccggtgt gaaaatataa 2815861 cgccctgctg cggcaaaatg agacggaggg ttttgtttag gcttttccac aatatcctgt 2815921 atgcgataaa gccctttttc aacaggctcc ccttttatca ccccgtaatg atgtaaatcc 2815981 tccgtttttg tttcttttaa gccgatcaca ctggactgat atttcgtata cgcttcaatc 2816041 agctgcccca aagccggctg attggcggaa aaaatcagat catctggcaa aacgacggca 2816101 aaaggctctc ctcctgcaaa ttgctttccg aaagaaatgg cgtcgccaag accctttgca 2816161 taaggctgcc gcacatagtg aatccgtata tccggaatgg gatgctctct aagtaaatgc 2816221 agtttattct tagaggccaa aaaagcctca agtgccaaag aggaatcaaa atagtcgaca 2816281 atcagatttt tatggctcga tacaaccatc aaaatgtcct caatgcctga ctcctttaat 2816341 tcttcaacaa gataatgaat cacaggctta gatcctaccg gaaacatttc tttcggaatc 2816401 accttcgtca ccggcagatt tctcgtgccg aatccgcctg caggaatgat cgcttttttt 2816461 atcatggtat tttcccctca gctcatgttt attacatgat attccaagag cgcatcccga 2816521 tgtttgtaca tctgaaatta ggcggaagca actgggcaga aagcggaatc acgaaccagc 2816581 ccttttttaa taggatattg atatatgacc agtaatcttg taaaggagct caggtgatga 2816641 aaatttgtgt ggttggcgcc gggtatgtcg gtttaaccct atcagcggca ctggcatcca 2816701 tcggacatga catgatatgc acagacaaag acgtcaaaaa aatcgggcag ctgaaaaaag 2816761 gagtcattcc cttttacgag cctgggcttt cagatgcaat acttcgttgc ggcaatctct 2816821 cgttttcttc tgaagtgaaa tcgagcatgg aggaatgtcc cgttattttt atcgcagtcg 2816881 gaactccgcc gcgttcggac ggatcagctg atacgaaagc cctgcagtcc gtcatcggtg 2816941 atttaagcga ggcgatccga tcgtataaaa ccattattac gaaaagcact gttccgcccg 2817001 ggacaaatga aaacatagca aaacagctga ttgcctccgg agtgtctaaa aacctcttta 2817061 atatcgtatc caatccggag tttctgcggg aaggcaatgc cttatatgac atgctgcatc 2817121 ctgacaaaac agtcatcggt gttcaggaag aagatcacgt atcggcagcc atcgtcaaat 2817181 ccatttacaa acacattgat acccctttta tcgttacaag cttagcggga gcagagctga 2817241 tcaaatatgc caacaatttc tttttagcgg ccaaaatttc gttcattaac gaaatggccc 2817301 gcatatgtga agcctatcaa tcagatatct cagatatttc ccgcgctatc ggtctagacc 2817361 caaggatcgg gaagcacttt ttgcaggcag gcatcggata cggaggctct tgttttccaa 2817421 aggatctgca ggcgctgcaa tttgctgccc aggaaaaaaa cacggagacc ttcctgctcc 2817481 gggccgtgca gcacattaat gacacccagc ttggcctgta tatcaaaaaa atacagtcat 2817541 tcttcgaaac acttcaaggc aagaaagcgg ctgtactcgg catttccttc aaaccgaata 2817601 ctgatgacat ccggaattct caggctgtca gactgatgga aaggctggcg gagctgggat 2817661 gtgatgttca tgcatatgat cctgaagctg tacttccaga acatttgcgg caacatgtaa 2817721 ctcagcattc tcaagctttt gatgcgatcg aagagagtga ctttttattt ttggcgacag 2817781 aatggtctga gtttttagcg tttgattgga aaaaggctgc agatatcatg aaagggcgtc 2817841 ttgtgattga cggacgcaac gtactaaaaa aagaactgat cgaggcttgc ggcctgatct 2817901 gtacgggagt tggccgtcca tgaaaatact cgtcacagga gcagcgggct ttatcggctc 2817961 ccacctctgc gaagaattac taaaagataa gaaacataac gttatcggaa tcgatgactt 2818021 tatcggtcct actccatttt ccttgaaatt aaaaaacctt aaaaacctgc tgccggaaaa 2818081 gcgatttacg ttcataaagg aaaatctgct gacagccgat cttgcttcct tactggaagg 2818141 agtggacgtc atctttcatt tggcggccat accgggtgtc cgctcaagct ggggcaatca 2818201 ttttcaccca tatgccgcac ataatatcca agcgctccaa aggctcctcg aggcgtgccg 2818261 ggaacattct attcaaacgt tcgtctttgc atccacctct tccgtctatg gcgaaaaaca 2818321 aggaaaagtc agcgaaaaca cgtcgctttc tcctttatct ccgtacgggg taacaaagct 2818381 tacgggagaa aagctttgcc atgtgtataa acagagcttt ggcattccaa ttgtgattct 2818441 ccgttttttt accgtatacg ggccaagaca gcggccggat atggcttttc accggctcat 2818501 taagcagcac cttcagcaaa agccgcttac catcttcggt gatgggcagc agtcaagaga 2818561 tttcacttat atcagcgact gtgtcaaagg catcaccgct gttcttggga aaccccacct 2818621 tattggtgaa acagtaaata tcggcggcgc agagcgtgcc tcagtcttaa aagttgtctc 2818681 cctcattgag gatatttccg ggagaaaagc aacactgcac ttttcggaca aaatagcagg 2818741 ggaaccgagc aacacgtggg cggatatttc aaaagcaaaa cagctcttgc attatgatcc 2818801 cgccacatcc ttaaaggatg gcttgaccaa cgaaatcgcc tatttatcgt cgctgtatca 2818861 gggggaataa aaatgaagct tgcctttatc tgtacagaaa agctgccggc gcccgcagta 2818921 cgcggcggcg ctattcaaat gatgattgac ggtgtcacgc cctatttcag cagcaggtac 2818981 gacctgacca ttttttcaat agaagatcca tcgctcccaa aaagagaaac aaaagacggc 2819041 gtacattata tccatctgcc aaaagaacat taccgcgagg cggtagccga agagctgcga 2819101 gcctcttcct ttgacctcat tcatgtgttc aacaggcctt taaatgtctc tttatataaa 2819161 aaagcctcac caaacagcaa gatcgttctg agcctgcata acgaaatgtt ttctgaaaaa 2819221 aagatgacct tcgcgcaagg aaaagaagta ctcgacaatg tctccatgat cacaacagtg 2819281 agcgaattta ttaaacaaac cgtcattgaa cgtttccctg aagccgagga catcacaaaa 2819341 gttgtgtatt ccggcgttga tttaaactct tatccgcccg tctggacgat gaaaggctcg 2819401 gctgtcagaa aaacataccg gaaaaaatac ggtattgaag ataaaaaagt tattttattc 2819461 gccggccgct taagcccgac aaaagggcct caccttctca ttcacagcat gagacggatt 2819521 ttgcagcagc accctgatgc tgtactggtc atagcaggcg ggaagtggtt cagcgatgac 2819581 agcgaaaacc aatatgtcac ctatctgcgc acgctggcgc tgccatacag agaccacata 2819641 atctttacaa aattcattcc cgcagacgat atcccaaacc tttttctgat ggcagatgta 2819701 tttgtgtgca gctctcagtg gaacgaaccc ctcgcccgtg tgaattatga agcaatggcg 2819761 gccggcacgc ccttaattac cacaaaccgg ggcggaaacg gtgaagtcgt aaaacacgaa 2819821 gtcaccggcc ttgtcatcga tagctacaac aaaccttctt catttgcaaa agcaattgac 2819881 agagccttta cagatcaaga attaatgaac aaaatgacaa aaaacgcccg aaagcatgta 2819941 gaagctttat ttacctttac ccatgctgcc aaaaggctca atactgttta ccaatccgtt 2820001 ctgaccccga aaaacaaaca atttccgccg ccttttctga cgcaaaattt tgatttatca 2820061 tctatcaatc agctttttgt gaaagcaaaa acataaaacc tacagctcgt gttgcaaaac 2820121 gggctgtttt ttcgctacag agaacttaaa aaaaggcata aatgtgactt tatgccttgc 2820181 gctttacagt ttgagaaaac catggagctg gtttagattc acttggaaga atgatgattt 2820241 ccactttagc ttcttccgct aagtctggtt cttcatcttc atcctcttct tcatatgggg 2820301 gcgctgagcg tttcgaatca cgctcctcct caggctccag agtggtttcg aattttgttt 2820361 cttcttcatc atcgacgatt ttgcgatctg tttccttttc cttcgtttct ttttgatatt 2820421 ctttcggtgc attgatgtga gggagctctc gaatgctgcc cacatctaaa tgcttctcct 2820481 cttcttcctt ctcagctgag attgagtcat gagcctgcca tcccatcggt ccaggcggtg 2820541 taaatacgaa ttggtcgaga tccagtttag aaatagaggc tttttgtctc gatgacctca 2820601 tgtcaattcg cctcccgata cgcttttatc tttttataca gttccggcag tttatccaaa 2820661 aacgaatctt tagattcttc aacagaaatc atgttttgca gcgcccagtt atacttctca 2820721 tctgaccacg ttttcttttg cttcaaataa tatttgtgcc cgattgcaca gaacaaatgc 2820781 ggaaacgcga gatcaatcca aagtacctcg tactgttttt ctgtgagcgg atacactgcg 2820841 tcgtaggccg caagcagtgc aaccatgaaa tcagtatccc atacagaaag cttaaccatc 2820901 actttattca gcagaatacg aaggtctctt gacggcaaat cgtaggtaat cgagtgaagc 2820961 tcctttaaaa aaggctcccc ttcgatctca gtcaaacgtg ccaatgtaaa atcctgaaaa 2821021 cagaatccgc catgctcgag tgtctctttt gtccaggttt cgtattctga gtcatcaagc 2821081 gctctgagag cttcttttcc tcttgccagc attttatcag catgttttaa gaaagtttgc 2821141 gaaaatacgt catcaggata ggatgctgcg atctgcatat tcccttcaag ttcctgcagc 2821201 ttccaacggt acaatttgtg ccattttccc agcctgcttc tcttcttgct ttcatctgtg 2821261 caaacatatc cttttgaggc atgatgaaaa tggccggcaa atgacatgac ttttttcatt 2821321 tgctctgcat catagtaaat catttctttt cctgtcactt tgtcatataa actgtaagaa 2821381 acctgatccg tgcccaagca gctaccgcca ttttttgttt gatgaatcgg cgctatcggc 2821441 agccctttct cttgtaaatg ggcgtgtgcc tgagtgataa aaagcatccg ctccggtttc 2821501 atttgcgctt cttttagcag ctttgggcca tgatcagttt cgacttccca gattttgcgc 2821561 ccgcttttgt tcgatttcag cgccacatgg tcgatatgaa acggataata actgagaatt 2821621 tcggacacaa tctgttcttc atgctctttt tggtacactc tgttcacccc ttctatctgt 2821681 tcttttcata gacgctgagc agattttcag ccaccctctg ccagccaaaa ttgctttctg 2821741 cctcacggcg gctgtatttc ccaagccgtt cccgcttttc cgagctgctc agcaaatcat 2821801 tgatacgttc ggcatattgt ttaggatttt caaagtcatg aatgatgtag ccgtttttcc 2821861 cttcctctat gacctctgga ttgcctcccc gattgcttgt aataatagga agtcccgcag 2821921 ccatcgcttc ataatgcacc cttgctaaag gctcctgcca ttgcgaagag catacaaata 2821981 catctgacat ggtataaagg cgcggaatgt cctttggctt cacaaattga ataaatgtga 2822041 catgatcctt ttgcatcgca ccaagggtat gaagatgttt gacatagtta tttaattcat 2822101 tatctccgaa ccattttgac ccgataaaca ccatcatgac atcggggtgc tcctcaatga 2822161 tgtccggcaa agcctgcaat aatatgtgcg ggcctttgac tttgctaagc cggccgacaa 2822221 acaagacgat ttttttgccg tgaagcccca gctcgcttcg catctcttcg cgagctcgct 2822281 gcccttcatt cgtccagcga gggtggtacg tttttaaatc cacaccagaa tacaccgttt 2822341 ttgtttttga tcgtgctgac ggaaaacggc ttgtgatcgt ctgtccgata taatcgctga 2822401 ccgtaacaat ctgcgctacg gagtcgatgc aaatctcgcc ttccgcctgg ctgattttat 2822461 cgtaagcgaa catttcattg tgaacgctta aaataaaaac agcatccggc gcctgtttct 2822521 tcaatttcgg aacccagctt gggcgattac aaacatgcac aagatcaaaa cggctctttt 2822581 tcagctctgc tccaacggct tcttcataac ggtcttcatc caaatgcaca taatggacac 2822641 cgtctacctt ctctctatca gcgagattcg gatctttaat agaaaacaca gtcacctcat 2822701 gtttttttgc aattaaaggg gcaaccgctt cgaggtagat ttgaatggcg cctcctcgaa 2822761 ccgatgggac aggaagcttc tctgtggcga tcagtgctat tttcatacat agcctccatt 2822821 cctgcatgat ttttaactag ttagaatcat gatacggctg aacaaccaac ttgtgcggaa 2822881 tgggactgcc ctaaaaacaa aacgggtaaa caaccagatt catctattaa atatagtcaa 2822941 ataactcaat cattttttcc ttttgattca taaggtagga gtaaaacagg taaggatgtg 2823001 tcctttaatg gcagaaaacc atgaagtcat tgaggagggg aattcatcag agcttccttt 2823061 atcagcagaa gatgcaaaaa aattaacgga gctggctgaa aatgtgcttc aaggatggga 2823121 tgtgcaggct gaaaaaatag acgtcattca gggaaaccag atggcgcttg tctggaaggt 2823181 ccacacagac tccggcgcgg tttgtctaaa acgaatacac aggccagaaa agaaagcgtt 2823241 gttttccatt ttcgcgcagg actatttagc aaaaaaaggc atgaatgttc ctggcatact 2823301 cccaaacaaa aaaggcagcc tatattctaa gcacggctca tttctatttg tcgtatatga 2823361 ctggatcgaa ggaagaccgt ttgagctgac tgtaaagcag gacttggagt ttatcatgaa 2823421 aggccttgct gattttcata cagcttccgt cggatatcag ccgccaaatg gcgttcccat 2823481 atttaccaaa ttaggtcgct ggccgaatca ctacacgaaa cgatgcaaac agatggaaac 2823541 gtggaagctg atggcggagg cggaaaaaga agatcctttc tcacagcttt atcttcagga 2823601 gatagatggc tttattgaag acgggctgcg catcaaagac cggcttttgc aatcgaccta 2823661 tgttccatgg actgaacagc tgaaaaaaag ccctaacctt tgccaccagg attacggaac 2823721 cgggaataca ctcttaggag aaaatgaaca gatttgggtc atcgacttag ataccgtatc 2823781 atttgatctg cctattcgcg atttgcgcaa aatgattatt ccgcttttgg atacgacggg 2823841 tgtttgggat gacgaaacat ttaatgtcat gctgaacgca tacgaatcca gagccccatt 2823901 aactgaagaa caaaaacaag tcatgtttat tgatatgctg tttccttacg agctttacga 2823961 tgtcattcgc gaaaaatacg tccgcaagtc tgctttaccg aaggaagaat tagaatcagc 2824021 ttttgaatat gaacgcatta aagcaaacgc attgcggcag cttatttaag accatcattt 2824081 cccccgcata tcgggggttt gatatttata agataaaggg taattaaata catgcggagg 2824141 ttgcaaatat gaaaaagatt gtcggcgctt tagccgtttt tgtgattaca tatgcgctgt 2824201 tttcagccgc aggctacctg tttcctgtgg accaagaatg gtacaattca ttgaaaaaac 2824261 cggactggac gccaagcgga actgcgatcg gcatcatttg ggccatcctg tttgccctga 2824321 tctccctttc agcagccatt gtatatgctg cgttttcatt taaaggtgcg aaaagctttt 2824381 ggtttacact tttgataaat tacgtgctca atcaagcctt cagctatttc cagtttacgc 2824441 aaaaaaatct gctggctgca tcgcttgact gcctgcttgt cgccatcaca gcaatcgtat 2824501 tactgatcat tgccaaaaaa tacagcagag ccgcaagcta tcttcttttg ccttattttt 2824561 tatggagtgc atttgcgacg ttcttatcct ttacaatcaa ttcaatgaat ctgtgaacaa 2824621 aaaaagccgc ttatacagcg gctttttcac atcatcggct tgatgcccca aatgtccttc 2824681 gcatattccc ggatcgtgcg gtcgctggag aaatatccag aatgagcaat gtttacaatc 2824741 gaatgctcag accatttcct tcgctctcga taatcagctt gaattcgctc ctgtgcatct 2824801 gcatatgagc tgaaatcctt cagcacaaaa tactcatcat tatgcggaag cagcgagtca 2824861 aagatcgatt caaattcatc tgcctctcct tcaaaaaaac cattgatcaa ctgatccgct 2824921 acctgcctga ttctcctgtc atgctgataa tattccctcg acctatagcc gccgttttcc 2824981 tgatacgata gaacctcatc cgcctttaag ccgaacgtgt aaatacagtc agggcccacc 2825041 cgctcaagga tctcgatatt tgcgccgtca tgcgtgccga tcgtcaaagc cccgttcatc 2825101 ataaacttca tattccctgt accagacgct tccttgcttg cggttgaaat ttgctcactt 2825161 acgtctgatg ccggaaaaat tcgctcagcc atagaaactc tataattttc taaaaaaaca 2825221 actttgatca gctgtttgac cgccggatca taattgactt tttctgcgac agaatggatc 2825281 agcttaatga ttttcttggc ataataatag cttggtgaag cctttgcccc gaaaataaag 2825341 gtttgcgggt agattgaaaa ccccgaatcc tccttgaggc ggttatacaa atacataatg 2825401 tgaagaacat tcagcagctg ccgtttatat gcatgaagcc gtttcacctg tacgtcgaat 2825461 atgctctcag ggttcacaac caccccggcc gtgcaaaaaa tcaaatcggc aagctcttgt 2825521 tttttcttgc ttttgttgtt ttgaaactgt tcaataaatg caggatcagt ggcgtacggt 2825581 tctaaacgga tcagtgattc cggctgcttg acccattcat cgccgatcgc ctctgtaatg 2825641 atggcagaca agcctggatt cgcttttaac agccagcgcc tgtgggcaat tccattcgtc 2825701 ttattgttaa aacgattcgg aaacagcaag tgaaagtcgc gcatctccct ttcctttaat 2825761 atatcggaat gtatttttgc aacgccattt acactgtagc tgcctactat ggccagatga 2825821 gccattttga caacaccatg cgctgtaatc gccatgttct ctatcctttt ccagtctcca 2825881 ggatactttt cccaaactgc acggcaaaac ctctcattga tctcttcaat aatcatgtac 2825941 attcgcggga gcagcggctt aaacaaatga atcggccatt tctcgagcgc ttctgacaat 2826001 gttgtatgat ttgtataaga aatcgtatgt acagtgatat gccaagcttc ttcccagctc 2826061 atgttctctt catcgagcaa aatccgcatt agctcaggca ccgcaagcgc agggtgagtg 2826121 tcattaatat gaatgctcac ttttttatgc aggccggata aagatttatg tgttttacgg 2826181 taattgttca caatgctttt taagcttgcg catactaaaa aatactgctg cttcagccgt 2826241 aaaattttcc cctcatcatg ggtgtcatcg ggatataaga attcagaaac cgcttctgtt 2826301 tctcgcttat aagacaaaat attaccgccg tgataatggg catagggctc ggcgttccaa 2826361 agccttaacg tgttgacagt gcccgtttca tagccgatga tcgggatatc ataaggaaca 2826421 gcggtaacaa ttgtcgcttg ttcatggcga aaatgcaggc gcccgctttt ttctgtcata 2826481 tggacttcgc cccaaaacgg cacgtccact gcttgatccg cattccttac ttcccatacg 2826541 ttcccgtttt tcagccattg ctcaggcagc tccacctgat gtccgtctac aattttttgc 2826601 tcaaacaaac catgcttata acgtatgccc atgccgtgcc caggcaggtt caacgaagca 2826661 agcgaatcta aaaagcaagc ggccaagcgc ccaagtccgc cattgccgag acctgcatcg 2826721 ttctctatct gaaggatctc ctctaaattg atgccgattt cctttaaacc agcttctaca 2826781 acatcacgaa caccaagatt cattaagttt tgctcaagga gctgaccgag cagaaattcg 2826841 attgataaat aatatgtctg cttcccggaa tttgatctgc ttttttcatt cgtttcgatc 2826901 caatcagcgc tgatatactc tctgaccata ttgcccaacg ttttatattg atccagcttg 2826961 gcagaatctt taaagctttt tccgcacgtc atttccagac gctttaaaaa taagtctgca 2827021 aagcgttctt tactcgagaa catcccgtcc actccttgtc acctgctcga aaatacgctg 2827081 atactcttta gccgacttcc cccagctgta atctgcattc atagcggtct tcacgatgct 2827141 cttccataca tcctgttggc aataaaacga cagcgccctt tctatcgtaa atttcagatc 2827201 atgcgcatta aaggcggaaa acgtaaagcc attgcccgtt ccctcttcct cctgataggc 2827261 acggacagtg tcgtaaagac cgcccgtttc cctgacaatc ggaatggcgc catattgaag 2827321 agcaatgagc tgccccaaac cgcacggctc aaatttcgac ggcatcaaaa acatatcaga 2827381 gcccgcataa atttgatggg ctagcggctc atcaaacccg atataagccc ggcacttctc 2827441 atgaaaagca aattctgcat accggaaata atcttcaaat tcacgttctc ctgtgcctag 2827501 cacaaccagc tgtatgtctt gctcctcaag aagttcgtgc ataattctgc ggacaagatc 2827561 aagccccttt tgtttagtga gccttgtcac catactgatc agcggaatat cgtttttctc 2827621 tggaagcccc atccgctgct gaagcttcgt tttgttttcc agcttgcatg caagatcccc 2827681 tgaatcgtat tgcgcctcta tataagggtc gcttttcggc tgatagaacg tatcatcaat 2827741 gccatttaat atgccggtta catcatcttc cctatattgc aaaacctgtt ccaactgctc 2827801 accataatac ggcgtcatga tttcatttct gtaagtgggg ctcacagttg tcacatgatc 2827861 agccgcaatg atgcccgctt tcataaaatt aacaaatccg ttgcattcta acctttcata 2827921 atgaaaatga tccatctcaa gacccagcaa gtcatgtgtg acatcaggag ggaatatgcc 2827981 ttgaaactgc aggttgtgga tcgtgagcac gcttttcatc cgttcataaa aaggatgttt 2828041 tctgtactcc tctttcagca aataattgac catcgctgta tgccaatcgt gagtatgaac 2828101 aatatcggct tgaacattca caactttggc agcctccagc acagctcttg aaaaaaaggc 2828161 aaaccgctca ccgtcatcat aatgcccgta caacgaatcc ctgttgaaat agtactcatt 2828221 gtcgatgaag taataattca catcattctc tgccatatgt tcaattccgc aatattgctg 2828281 ccgccagccg acagctacgg tacactcagc ctgttttttc atacgctttt tccacggttc 2828341 aggtatttgg ctgtacttcg gcagcatcac agctacctca ttgcctaatc gcgcaagcgc 2828401 ctttggcaga gcacctgcta catcggcaag acctcctgat ttcacaaatg gggtgcattc 2828461 tgacacagca aataatatct tcaagaattc atcagctctc cttgcaccaa accttttctt 2828521 aatacaagcg gctgctcagc tgttcctgca gcttccgtcg ccttgccgat tttaacatcc 2828581 ttatccgaaa tgacctgctc aagaagacaa tcctctccaa tctgcgtttt ttgcataata 2828641 atgcagtttt tcagcttcgt accctttccg acatggaccg ccctgaacaa aatgcagttt 2828701 tcaacctctc cttcaagcac acagccgttt gccaccaaag aatttttgac agtgctgtgc 2828761 tttccgtatt tcgtaggcgg ctcatccttc acttttgtat agatcggctg ctgcggcaaa 2828821 aacacctgct gccaaaaacg aggctgaatg agctccatac tgtgggtata atatttttcc 2828881 accgaatcaa tgacagcggc ataacctgaa tattcataag ggcaaatggt cagggcggaa 2828941 gattcctttt caacagcctc ctgaatggtt ttatagcctt tttcgctatg tccgtagatc 2829001 agatccttta aaagcgttgt tgacatgata tagatttgca gcgactggcc gtcctgaaat 2829061 acctcggtga cgtcgcagcc aacctcctga tggcgtttca gcacatattg aaattgaatg 2829121 ttgcatacgg tatggctgtt ggagattaca gcatattgct gagtgcttct gtggaagtaa 2829181 tctagatggt ccgaaaactg gcgaaaggaa ccgaattcat cgtattcgtg atgaagatgg 2829241 ggagacggga aaaaaaagag gccgtccttt ttccggtgca aatcccattc cttacccgcc 2829301 ccaaggtgat ccatgagcga acggtaacga tacttcggaa aaattgcaac actcctaata 2829361 tccgcattca ccatgttgga aagcataaaa tcaatcagtc ggtacctgcc ggcaaaaggg 2829421 atcgccccga gcgaccgctg tgctgttaaa tcctgaagag aatgcttata tgtggtttca 2829481 tctataacac ctaacatttg attattgaac actgactctg ccccctcttc agtaattaaa 2829541 tcaattcttt ttctacaaat tcctctgaaa cgagcagcac ctcttcaatg tctttttcgg 2829601 agcgaatcac tgcgccatcc ggcagcacca tcccattagg aacgatggca ttttcaatga 2829661 ctacatgctc cccaatcgtc acatccggca ttatgacgga tgatgtaaca gtcgtatgct 2829721 taccaacagt cacaccttga aaaagaacgg agtgagacac atttccatat acaacacaac 2829781 cttcgttcac aagcgaatct tgaacctgcg catcagatga aataaattgc ggaggctgat 2829841 ttggattgac ggagtaaatt ttccatttgc gttcaaacag cttcagctcc gagtcctctt 2829901 ttaacaaatc catattggct tcccacaagc tctgcaccgt tccgacatcc ttccaatatc 2829961 ccttgaacgg ataagcagaa agcttctttt tctcttccaa aagcagtgga ataatgtctt 2830021 tgccgaagtc gtggctagaa taagggtttt gatcgtccat ctcaagatac tgtttcaaaa 2830081 gcggccaatt gaatatataa attcccattg aggcaagatt gctcttaggg aatttgggct 2830141 tttcatcaaa atgtgtgatc gtcccatctg gattggcctt catgatgccg aaccggcttg 2830201 cttcctccca gcccacttcg atgacagaga tggtcacatc tgctttcttt tcaatgtgat 2830261 aatcaagcat tttgccgtag tccattttgt atatgtgatc tcctgataaa atcagtacat 2830321 actcaggatc atactgattc aaataattga gattttcata aatggagctt gccgtccctt 2830381 tataccattt gacttctgat gactcggcat aagggggtaa aaccgtcacg ccgccattat 2830441 atctatccag gtcccatgca ctgccgatcc caatatagga attcagctcg agcggctgat 2830501 attgcgttaa aatcccgact gtgtctatgc ctgaattaga acagttgctt agggtaaaat 2830561 caataatcct gtattttccc ccgaaagata cagccggttt ggccatattt tttgttaatc 2830621 cgctgagacg gctgcccttc ccgccggcaa ggagcatggc tacacattgt tttttcatct 2830681 ttttatctct cctctttttt taaccgcccg taaaatcgag atgccgtaag gggggatggt 2830741 catcgtgata taacacggtt tatgatgaag tgctcccttt ttagccgata acggcttttt 2830801 gttgatttgc cctgagcctc catatgtttc actgtcactg ttaagcactt caatgtattg 2830861 agtaaaaaaa ggaactccaa catcatattg atgatagacc acgggtgtaa aattacaaat 2830921 gatgacaagc gcctcaccgt gcttttggcc ataacgaata aaagaaaaga ttgattgttc 2830981 gtcattatgg acatcaatcc attcaaacga ttgtgcacga tggtcatgct cataaaggat 2831041 tttgcttttt tggtaaaagc ggagaagatc ttgcgtaaaa acgctggctt tctgatgcat 2831101 ggggaaggag tccaaaaacc aatcaagctg ttctgtatct ttccattcat caaattgagc 2831161 aaactctgat cccataaaga tcaatttctt tccgggatgc actgtcatat agcccagcaa 2831221 aagccgatac tgggcaaatt tctgccagta gtcgccaggc attttattga gaagtgattt 2831281 ttttccgtat acgacttcat catgagaaaa cggcaataca aaatgttcac taaacgcata 2831341 tagtaatgaa aaagagataa gctgatgaca atgccgcctt tcttcgggcg gcgtctccat 2831401 gtatttcagt acgtcattca tccatcccat attccattta taatgaaaac caagcccccc 2831461 ttcctcaacg gcacctgtca cttgaggcca ttctgtagaa tcttctgcaa tcatcatcac 2831521 atggggatat gcctctctca tggtttgatt gagttttttt aaaaaatcaa cagcatatgg 2831581 attcgtgtgg cgttcatcct gatttggcca atacaagata ttagccactg catcaaccct 2831641 aaatccatct atatgataga attccgccca gtacaacgca ttcgaaatta aaaaactatg 2831701 aacttccggt ttccccaggt caaagtttgc cgtgccccat aaccagttct cccgatcacg 2831761 ttcttctttg tattcataaa gcggttctcc atcaaacata taaaggccat gtgcatcttt 2831821 acaaaaatgt ccggggaccc aatccaaaat gactccgata ttttgttgat gacattcatc 2831881 cacaaacttc atcagatcat gcggcgggcc aaacctgctt gtcgggctgt aataccccgt 2831941 tccttggtac ccccatgaac gatcatatgg atgctcatac acgggaagca gttcaatatg 2832001 ggtaaaccca tgcttcttga tataagggat aagcgtctga cttaattctt tataggaata 2832061 atgcctgcca tcagaatgct tcttccaaga cccaagatgc agttcataaa tgaaaacagg 2832121 tttttcatac agcgtcttag ccttctgttt cttttgccat ttttgatctt gccagctgta 2832181 tccttccaaa tcgtaagtaa gtgacgctgt gtttggtctg acttctgaat aaatagcgta 2832241 tggatctgcc ttcagcctga tctcaccgtt attcgtcaca atttcgtatt tatatcgttc 2832301 cttttctcct atacctggaa taaataacgt ccaaatgcca ttatcattca ctctgtgcat 2832361 cacatgctct tctccagacc agctgttaaa atctccagcc actcgtactt ccgacgcatg 2832421 aggcgcccac acacagaatt catatccgct tttgccattc agctcgcggt aatgcgagcc 2832481 aaacagctga tagcttttaa acagactgcc ttcgtgaaaa agataaacat catgtgctgt 2832541 cgggctggca gcggccatgt aatcatcctt tctgacatca tagttttcat ttatagtatt 2832601 tattcgaaga aataaaaaaa agccctttcc tgaaagcgct tatacttata gacaattaac 2832661 ttcattttct gaagaaaaac gaaatatatg gagatttttg tagtctgttt ttaaaataaa 2832721 gaacaaaatc taagacatat catgatttat aaaaacaaaa aaaccttgca ggatatgcaa 2832781 ggcttctgga tgacccgtac gggattcgaa cccgtgttac cgccgtgaaa gggcggtgtc 2832841 ttaaccgctt gaccaacggg ccgataatta tgatatctgt aatcatatgg cggagaagga 2832901 gggatttgaa ccctcgcgcc gcttacacga cctacaccct tagcaggggc gcctcttcag 2832961 ccacttgagt acttctccat ttggctccac aggcaggatt cgaacctgcg accgatcggt 2833021 taacagccga tagctctacc actgagctac tgtggaacaa aagtcatggt gggcctgaat 2833081 ggactcgaac catcgacctc acgcttatca ggcgtgcgct ctaaccagct gagctacagg 2833141 cccatgacga tatagaaatg gagcgggtga tgggaatcga acccacgaca tcagcttgga 2833201 aggctgaggt tttaccacta aactacaccc gcaattttta tttggggcga ttgatgggaa 2833261 tcgaacccac gaatgccaga gccacaatct ggtgcgttaa ccacttcgcc acaaccgcca 2833321 aagcatattg ataaatggtg gctcgggacg gaatcgaacc gccgacacac ggattttcag 2833381 tccgttgctc taccaactga gctaccgagc ctaagtattt aaatggcggt ccggacggga 2833441 ctcgaacccg cgacctcctg cgtgacaggc aggcattcta accaactgaa ctaccggacc 2833501 attttaaaat ttggttgcgg gggcaggatt tgaacctgcg accttcgggt tatgagcccg 2833561 acgagctacc gaactgctcc accccgcgat gattaggaat atgtatggcg gaggaagagg 2833621 gattcgaacc cccgcgggct ttgacacccc tgtcggtttt caagaccgat cccttcagcc 2833681 agacttgggt attcctccgt atagtggtgg accttgtagg actcgaacct acgaccggac 2833741 ggttatgagc cgtctgctct aaccaactga gctaaaggtc cattggtagc ggcggagggg 2833801 atcgaacccc cgacctcacg ggtatgaacc gtacgctcta gccagctgag ctacaccgcc 2833861 aaatattttt gaaatcaagt ggagcctagc gggatcgaac cgctgacctc ctgcgtgcaa 2833921 agcaggcgct ctcccagctg agctaaggcc ccaagaatgg tcgggaagac aggattcgaa 2833981 cctgcgaccc catggtccca aaccatgtgc tctaccaagc tgagctactt cccgatttca 2834041 tatagatcat ggcgcgcccg agaggagtcg aacccctaac cttttgatcc gtagtcaaac 2834101 gctctatcca attgagctac gggcgcaaaa cttaatgccg agggccggac ttgaaccggc 2834161 acggtagtca cctaccgcag gattttaagt cctgtgtgtc tgccaattcc accaccccgg 2834221 cgtggatggt atagttggag cggaagacgg gattcgaacc cgcgaccccc accttggcaa 2834281 ggtggtgttc taccactgaa ctacttccgc agaaatggtg cggatgaagg gacttgaacc 2834341 cccacgtctg taaagacact agagcctgat tctagcgcgt ctgccaattc cgccacatcc 2834401 gcaacatgta aatggtgagc catgaaggac tcgaaccttc gaccctctga ttaaaagtca 2834461 gatgctctac caactgagct aatggctctt cttacaatag acttgaatat tatatcatat 2834521 aaaagtggtg ccggcaagag gacttgaacc cccaacctac tgattacaag tcagttgctc 2834581 taccaattga gctacaccgg catatatgta aaaccgatat gtataatgaa aaatggtgga 2834641 ggatgacggg ctcgaaccgc cgaccctctg cttgtaaggc agatgctctc ccagctgagc 2834701 taatcctcca tacttgcact aacgtgcaat tgcttggcgg cgtcctactc tcacaggggg 2834761 aaacccccga ctaccatcgg cgctgaagag cttaacttcc gtgttcggta tgggaacggg 2834821 tgtgacctct tcgctatcgc caccaaacaa attgagagtg ttctctcaaa actagataac 2834881 aggtgtgaca tcattcaaaa atatggttaa gtcctcgatc gattagtatc tgtcagctcc 2834941 atgtgttgcc acacttccac ctcagaccta tcaacctgat catctttcag ggatcttact 2835001 tccttgcgga atgggaaatc tcatcttgag gggggcttca tgcttagatg ctttcagcac 2835061 ttatcccgtc cgcacatagc tacccagcga tgcccttggc agaacaactg gtacaccagc 2835121 ggtgcgtcca tcccggtcct ctcgtactaa ggacagctcc tctcaaattt cctgcgcccg 2835181 cgacggatag ggaccgaact gtctcacgac gttctgaacc cagctcgcgt accgctttaa 2835241 tgggcgaaca gcccaaccct tgggaccgac tacagcccca ggatgcgatg agccgacatc 2835301 gaggtgccaa acctccccgt cgatgtggac tcttggggga gataagcctg ttatccccgg 2835361 ggtagctttt atccgttgag cgatggccct tccatgcgga accaccggat cactaagccc 2835421 gactttcgtc cctgctcgac ttgtaggtct cgcagtcaag ctcccttgtg cctttacact 2835481 ctgcgaatga tttccaacca ttctgaggga acctttgggc gcctccgtta ccttttagga 2835541 ggcgaccgcc ccagtcaaac tgcccacctg acactgtctc cccgcccgat aagggcggcg 2835601 ggttagaagg tcaatacagc cagggtagta tcccaccgat gcctccaccg aagctggcgc 2835661 tccggtttcc aaggctccta cctatcctgt acaagctgta ccaacattca atatcaggct 2835721 gcagtaaagc tccacggggt ctttccgtcc tgtcgcgggt aacctgcatc ttcacaggta 2835781 ctataatttc accgagtctc tcgttgagac agtgcccaga tcgttgcgcc tttcgtgcgg 2835841 gtcggaactt acccgacaag gaatttcgct accttaggac cgttatagtt acggccgccg 2835901 tttactgggg cttcaattcg caccttcgct tacgctaagc gctcctctta accttccagc 2835961 accgggcagg cgtcagcccc tatacttcgc cttacggctt cgcagagacc tgtgtttttg 2836021 ctaaacagtc gcctgggcct attcactgcg gctctctcgg gcttgcaccc taacagagca 2836081 ccccttctcc cgaagttacg gggtcatttt gccgagttcc ttaacgagag ttctctcgat 2836141 caccttagga ttctctcctc gcctacctgt gtcggtttgc ggtacgggca cctctcacct 2836201 cgctagaggc ttttcttggc agtgtggaat caggaacttc gctactatat ttcgctcgcc 2836261 atcacagctc agccttatgg gaaacggatt tgcctatttc ccagcctaac tgcttggacg 2836321 cggatatcca ataccgcgct taccctatcc tcctgcgtcc ccccattgct caaatggtga 2836381 ggaggtggta caggaatatc aacctgttgt ccatcgccta cgcctttcgg cctcggctta 2836441 ggtcccgact aaccctgagc ggacgagcct tcctcaggaa accttaggca ttcggtggag 2836501 gggattctca cccctctttc gctactcata ccggcattct cacttctaag cgctccacca 2836561 gtccttccgg tctggcttca cagcccttag aacgctctcc taccactgtt cgaagaacag 2836621 tccgcagctt cggtgatacg tttagccccg gtacattttc ggcgcagagt cactcgacca 2836681 gtgagctatt acgcactctt taaatggtgg ctgcttctaa gccaacatcc tggttgtcta 2836741 agcaactcca catccttttc cacttaacgt atactttggg accttagctg gcggtctggg 2836801 ctgtttccct ttcgactacg gatcttatca ctcgcagtct gactcccaag gataagtcat 2836861 tggcattcgg agtttgactg aattcggtaa cccggtaggg gcccctagtc caatcagtgc 2836921 tctacctcca agactcttac cttgaggcta gccctaaagc tatttcggag agaaccagct 2836981 atctccaggt tcgattggca tttcacccct acccacacct catccccgca cttttcaacg 2837041 tgcgtgggtt cgggcctcca ttcagtgtta cctgaacttc accctggaca tgggtagatc 2837101 acctggtttc gggtctacga ccacgtactc atgcgcccta ttcagactcg ctttcgctgc 2837161 ggctccgcat cttctgctta accttgcacg ggatcgtaac tcgccggttc attctacaaa 2837221 aggcacgcca tcacccgtta acgggctctg actacttgta ggcacacggt ttcaggatct 2837281 ctttcactcc ccttccgggg tgcttttcac ctttccctca cggtactggt tcactatcgg 2837341 tcactaggga gtatttagcc ttgggagatg gtcctcccgg attccgacgg aatttcacgt 2837401 gttccgccgt actcaggatc cactcaggag agaacgaagt tttgactaca gggctgttac 2837461 ctcctatggc gggcctttcc agacctcttc atctacctcg ttcttttgta actccgtaca 2837521 gagtgtccta caaccccaag aggcaagcct cttggtttgg gctgatcccg tttcgctcgc 2837581 cgctactcag ggaatcgcat ttgctttctc ttcctccggg tacttagatg tttcagttcc 2837641 ccgggtctgc cttctcatat cctatgaatt cagatatgga taccactcca ttacgagtgg 2837701 tgggtttccc cattcggaaa tctccggatc aaagcttgct tacagctccc cgaagcatat 2837761 cggtgttcgt cccgtccttc atcggctcct agtgccaagg catccaccgt gcgccctttc 2837821 taacttaacc gttaaaaaga atcactatgt gatatcttgt gttactaatt gaatgtgatg 2837881 tctactgtta tctagttttc aaagaacacg tttcgaagga atgatccttc aaaactaaac 2837941 aagacaggga acgttctgtt tataagacct tgggtcttat attccgtata atatccttag 2838001 aaaggaggtg atccagccgc accttccgat acggctacct tgttacgact tcaccccaat 2838061 catctgtccc accttcggcg gctggctcct aaaaggttac ctcaccgact tcgggtgtta 2838121 caaactctcg tggtgtgacg ggcggtgtgt acaaggcccg ggaacgtatt caccgcggca 2838181 tgctgatccg cgattactag cgattccagc ttcacgcagt cgagttgcag actgcgatcc 2838241 gaactgagaa cagatttgtg ggattggctt aacctcgcgg tttcgctgcc ctttgttctg 2838301 tccattgtag cacgtgtgta gcccaggtca taaggggcat gatgatttga cgtcatcccc 2838361 accttcctcc ggtttgtcac cggcagtcac cttagagtgc ccaactgaat gctggcaact 2838421 aagatcaagg gttgcgctcg ttgcgggact taacccaaca tctcacgaca cgagctgacg 2838481 acaaccatgc accacctgtc actctgcccc cgaaggggac gtcctatctc taggattgtc 2838541 agaggatgtc aagacctggt aaggttcttc gcgttgcttc gaattaaacc acatgctcca 2838601 ccgcttgtgc gggcccccgt caattccttt gagtttcagt cttgcgaccg tactccccag 2838661 gcggagtgct taatgcgtta gctgcagcac taaggggcgg aaacccccta acacttagca 2838721 ctcatcgttt acggcgtgga ctaccagggt atctaatcct gttcgctccc cacgctttcg 2838781 ctcctcagcg tcagttacag accagagagt cgccttcgcc actggtgttc ctccacatct 2838841 ctacgcattt caccgctaca cgtggaattc cactctcctc ttctgcactc aagttcccca 2838901 gtttccaatg accctccccg gttgagccgg gggctttcac atcagactta agaaaccgcc 2838961 tgcgagccct ttacgcccaa taattccgga aaacgcttgc cacctacgta ttaccgcggc 2839021 tgctggcacg tagttagccg tggctttctg gttaggtacc gtcaaggtac cgccctgttc 2839081 gaacggtact tgttcttccc taacaacaga gctttacgat ccgaaaacct tcatcactca 2839141 cgcggcgttg ctccgtcaga ctttcgtcca ttgcggaaga ttccctactg ctgcctcccg 2839201 taggagtctg ggccgtgtct cagtcccagt gtggccgatc accctctcag gtcggctacg 2839261 catcgttgcc ttggtgagcc gttacctcac caactagcta atgcgccgcg ggtccatctg 2839321 taagtggtag ccgaagccac cttttatgtt tgaaccatgc ggttcaaaca accatccggt 2839381 attagccccg gtttcccgga gttatcccag tcttacaggc aggttaccca cgtgttactc 2839441 acccgtccgc cgctaacatc agggagcaag ctcccacctg tccgctcgac ttgcatgtat 2839501 taggcacgcc gccagcgttc gtcctgagcc aggatcaaac tctccgataa atggatcaca 2839561 ggttaagttc accgcatcct gcggcgacac ctgtgtgacc tgcgtcgtgc aggccctagt 2839621 ttgactgact acgcacatcg cagtgcgatt tttaaaaact gaattaacag gtacgttttg 2839681 tcttgtttag ttttcaaaga tcatttcgtt acttctcaat gaagcagctt tactaatata 2839741 acattcagct tcttttttgt caacaacttt tttcaagttg ttttgaagca tctagtttgt 2839801 gtccgctgtg catcagcgac gtttaataat ataacacctg tatttattta ttgcaatagt 2839861 tttttaaaaa aaatctataa aacaaataaa ctataatcct cgccatgatt tctaaagcgt 2839921 gtgtatcata taagtttctt aaaagaacat atacatcagt catgtgatct tgttgttttt 2839981 ttcgttttct tgtatagtag aaacgaacta aatactgatg accacaaggg gagcattaaa 2840041 gctgagagtg agcggtttcg ttctgaccct ttgaacctgt tagttaacgc tggcgtaggg 2840101 atgtggcaaa gtcaaatgaa ttgcagatcg taaagcagtg cgtggaactt ttctcatcct 2840161 tccgcgtgct gcttttttgt tgtccttttg gttgtctgtc aatggaagga gatagatatg 2840221 aatcaatcta agcaactggt tcgccttatt gaaattgcca ttatgacagc ggcagccgtt 2840281 attttagaca ttgtctcagg aatgtttctt agcatgcctc aaggaggctc ggtctccatc 2840341 atgatgattc cgatcttttt aatttcgttt cgctggggtg tcaaagcagg tcttactaca 2840401 ggtttgttga caggtctagt acaaatagca atcggaaact tgtttgctca acatcctgta 2840461 cagctattgt tagattacat tgtcgctttc gcagcaatcg gcataagcgg ctgtttcgct 2840521 tcttctgtcc gtaaagccgc tgtatcaaaa acaaaaggga aattgattgt ttcagtggtc 2840581 agcgcagttt ttatcggcag tttgctgcgc tatgccgcgc atgtcatttc aggagctgtg 2840641 tttttcggca gctttgctcc aaaaggaaca ccggtatgga tttattcttt aacttataat 2840701 gcgacttaca tggttccttc attcattatt tgtgcaattg tcctatgttt attatttatg 2840761 acagcacccc gtctgcttaa aagtgacaaa gcgtaaaagt aacaatcccc cagcgaattc 2840821 cgctggggga tttttcgtta tctgttaaga agtgttttta aagctgaaag atccggccag 2840881 ccaagaccta cttctttcag ccttactccg gcaatttcaa agttgtcctc cgctactctt 2840941 tcaggtgaat aggcctgata aaatataatc gagggattct gctcaataac ccaaacaaac 2841001 atacttgaaa aaccatgttg aagcaaaaac tccgctcctt ttgctaagag cgccctgcct 2841061 gcaccttgcc gctggcgctc ttccagaaga taaatagcgt ataactcgcc gtcatagcct 2841121 tcttgttcag agcgaatagg tccaaatgaa gcaaagccga atactgaacc cttttcgtcc 2841181 tgagcaacaa atactccctt taacgagcga cttttccatt tgtcttcaaa ttccttatag 2841241 ttcaggctgt ttaaataatc aatcgggata atttcgtggt atgttgtcct ccagctgtct 2841301 acatgcactt ttgcaatgtc ctttatatcc tctaacttcg cttcacgtac agttaccata 2841361 cggttctgcc ctttccttac tctgattttt ggatcgtttt ggcttctttg atttcatttg 2841421 ttaattcatt aatgctttgt tttacgtttc cttttcctga aaagttctca agcatttctt 2841481 ttacatcaat tcctgaggat gcttttaaac tttcttgcag acttgacatt aagttcgtcg 2841541 catagctggt tactttgttt gctccgcttg attcaccgct tcctcctgta tcgacaacgg 2841601 tgattttatc aatatttgaa agaggtgccg ctgcttgttt cgcgtattcc ggaagcattt 2841661 tgacaatcat atcgaaaatc gccgcctgcc cgtactgttc aaaggcggcc gcaattttct 2841721 cttttgcttc cgcttctgca agacctttca ggcggataac ctctgcttct gtctctcctt 2841781 tcgctttttc cgcttctgct tttgctagcc cgtcaattct tactttttcc gcctcagcct 2841841 ttgccattgc ttcaatactg tacttcttgg catcggcttc cgcgagctgt ttggctttct 2841901 cagctgctgc ggactgctca acagaataac ggtctgcatc ggcttttttc tttacctctg 2841961 agtcgtattg acgttcacgg cgaagaattt ctttttcttc tagttctatt tgtttttggc 2842021 gttcgataat tttaacctgc atttcctgct ctgtgacttg ctggcgcgct cgggcagtct 2842081 ctaaatcata tgcttggtcg gcattcgctt ttgccgtatc ttgttctctg cggaattcag 2842141 ccattttgag ctgattgatt ttttcagctt cagcgatttc cgtcgcccgt tcaagttctg 2842201 atttttttgc gtctttatcg gcttctgccc gcttaattcg ggtttcttta tcagcctctg 2842261 ctgttgcgat atcagcatcg cgttttactt gggcaattct cggtttccct aatgattcaa 2842321 gataaccgtt tttatcacga acatctttaa tggtaaacga gacgattaca agtcccattt 2842381 tcgcgagatc ctgtgaagcg acacgctgca cctcttgaga gaatttttct ctgtttttat 2842441 agatttcttc tactgtcatt gagccgagaa tggaacgaag gtggccttct aaaacctccc 2842501 gcgcttcctg ctcacggtcg tcttttgatt tccctaaaaa ttgttcggcc gctgtagcga 2842561 tttctcctat agaaccgccg attttaataa tcgcagttcc atcggccatt actggcactc 2842621 cttgttctgt atagacttca ggtgtcgaaa catcgagttt gcttgataat aggcttagcg 2842681 gctctgcctg ctggaagacg ggaaggacaa aggttcctcc gccgcggacg attttaatac 2842741 ggttgccgcc ttcatcgaca tgaacatttt tattacccag atagctccct gttacaatta 2842801 acgcttcatc aggccctgct gtacgatact tcgtaataaa cacagctatt agtgcaatta 2842861 ataaaaagaa tacaactccg atgatcatta taatcggcat tgtcatatca aattcctcct 2842921 tttatgttaa atgggttcat gcggagtaac cgaaagaact ccgttgttaa tatctacgac 2842981 taacaccgtt gtcccgtaac tgatctgctg attatcaaaa ctgaccgctg actttgaaat 2843041 ggtcccgcct atcccttcta tgaccacttc accaaacccg tcaaccggca cagctgtaat 2843101 cactttaccg agtcttcctc tgagatcatc ttctctatat gccaatgatt cttctgcaga 2843161 tgataatggc accagtacaa agatgtgaag caataccacc agcatgatcg aaaggatgca 2843221 agataaaagc gcaatcagca agcttgacag aggcaataca agttcaccta tatatccgcc 2843281 cgctgaaaaa catgtaaaaa atgagagcac taatgtcgga ttaagaaacg gaatgccttc 2843341 tgacagccct gaaaatacat ctccgaaaaa caggaataac agcgtaaggc tgcccgcaat 2843401 aataagcgta taaagataca ttgtttgtat aggtactcca aataactcca acttcctcat 2843461 cctttcttca tcaatgcatt gatgaacggc tgccgttacc atttatacga gacacctcgg 2843521 gaaaagtttc aaaattttaa gacaaataac ccatttgaag tgctttataa atgataattg 2843581 cttatatata tggtaatgtc attttaggag gagatatgat gagtatcttt aatgaagcca 2843641 gattagaaac gtggaacgaa ttgaaaggac tttctgacga aaagctgaat caaaagcctt 2843701 ctgctgaaga atggagcata cgggaagttc ttgaccattt gaaaaaaatc gatatgaccg 2843761 cacaaaaaat gttgaaggaa cgtgtaaagg acgctccgat taaagaaatt gaagaaaaac 2843821 cgcttgaagt agcacaggac agaaataata aacggaaagc cccgagtcat cttgagcctg 2843881 cgcatgattt tatttcaggc agccaaatga aacgtgagct tgatgtggta agagagcagc 2843941 tgactgctgc gattgcctct ctgaaagaag aagattttga aagagtgctt ccgcatcctg 2844001 tgtttcaaga gctgactgtc agacagtgga tcgattttat cggccatcat gaaaaacggc 2844061 acctcagcca aatgaaagaa attaaagaaa agatagaaag ggcctgattt aatcagaccc 2844121 tttctgcttt tcgtttgact tttcgctgat aggaatgaac ttctatttca tcacctgtgt 2844181 aaacagcacc aggtctctcc acaatacaga caatccctct aatgcccagt gcgtggcgga 2844241 cgaaagccga cgccagcttc ggttggtccg gataataaga ctgaatgact tctcccggct 2844301 ggatacacgg atcattttcg ccctcacaca gcagagccgc tccgctcgga aaaataatcc 2844361 ggcttccttc ttttaatgaa gtaagatctg gcataccgct gactgccaca ttcgccccga 2844421 gccattccgg caaaattctc ggcactccca tttttaaagc gatttcgttg cattcctcta 2844481 ttgaaacaat tgaaatttgt ctgcggttga aaatttcagt ccctcttgaa aacattggtt 2844541 ctctggctcc cgcttttttg gtcaggccaa aatgcaagtc gccggggatg ccgccataat 2844601 caaaatcaag cttgtccatt tgctttgtta cgaagctttt tgtatctgcg atatataagc 2844661 cttccgcttt tgcagtcata cgcttccaca tcagctggca ccttccttct tatctaaaat 2844721 ttccacctat gcttcattat cccaaaaaat cccgctctgt aaaggagcgg gattttgatt 2844781 ataccgtttt aggcgtaagg ttaaagcagc gtttgtagat ccagttgtat gctttttcat 2844841 ttaaatctct agggtttccg aaggtttgcg gatctttcat tgcttcttta gacaagcgtt 2844901 cgatcatatc aggtgatact ccctgctctt ctaaagtcgg cacttctaaa tcttcgacca 2844961 gatcatacat ccaattgaca gatgctttcg cagcttcttc tgttgtcatc ttgcttgtat 2845021 caataccgaa cgctttcgca atacgcgcaa acttctcagg atagcccttc cagttgtatt 2845081 ccatgacagg gcccatcatc gccgctacac attggccgtg agcgactggg ataataccgc 2845141 caagcgtttg gctcatcgca tgagcagcgc ccgctgattc acttccgtaa gaaagaccgg 2845201 caagcatcgc agcctgcgcc attccgtacc ttgcttccag atcctctcca tcagcaaatg 2845261 ccctcttgat gtaatgagcg gcatactcaa tcgccattaa ggcaaccgca tccgtgattg 2845321 gctgtgcaaa tttcattgta tagcactcaa tggcatgggc gagcgcatca attcccgtca 2845381 tagctgttac atgcggaggc attgaaacat gaagctcagg atcaatgatt gtcaagtgcg 2845441 ctgcaatcag cggaccgccc gtgttgaatt tgaattctct ttcttcatct gtgataaccg 2845501 cccattgggt tacttctgat ccggttccag ctgtagtggg aattgtcgtc agcggaggaa 2845561 tgcggttttc cagcggtttt ttcccatctg ccgcttcata atcaagcacg cttccttcgt 2845621 gagtcgcttc tactccgatt gcttttgctg tatccatgga gcttccgcct ccgactgcca 2845681 ccaaaccatt acagttctct tttttgtaaa gctcagatcc ttcattcacc agacggacag 2845741 gcgggtttgg ctcaacttta ttaaagagta ccacttcaat gcctgcttct ttaagtgatt 2845801 cgattacggg atcagcaaca ccggctttat aaatcccagg gtctgtgaca aggagcgctt 2845861 ttgaaacgcc cagtgcagct acttcctcac ccgtatgctt gatggctccg attccatgct 2845921 taatcacagt cggaatttca aatgtgtgga atttctgcat gctttctacc ttcatattta 2845981 atgtcatcat caatctcccc ctcttatgaa ttaaaccagt taaccgctgc cggttttgta 2846041 ttgcggtata catgtttgac ttctgtgtat tcttcaaggc ctatttttcc aagctcgcgt 2846101 ccgaacccgg attgcttata tccgccccat ggcgcttgtg caaagtacgg atgaaaatcg 2846161 ttgatccaaa cggttcccat tctcaagcgg gctgctaccc gttcgcactt ttcaatgtct 2846221 tttgaccata ccgctccagc caagccatag atggtatcat tcgcaagctc gattacctct 2846281 tcttcagagc tgaaggtttc gactgtcaat acaggaccga aaacctcttc ctgaacgatt 2846341 ctcatgtcag aattacagtt tgagaaaata gtaggttcat agaaaaagcc gttttgaagc 2846401 tcaggatctt ccgggcgttt gcctcctgtc tccagcttcg cgccttcctc tattccgatc 2846461 tctacatatt tttctacctt tgccctgtgc tccgccgaaa taagcggacc gctttctgtc 2846521 tcagcatgaa aaccgtttcc gagttttatg cgttttgccc gtttgaccag ctccgccaaa 2846581 aattgatcat gaatggcatc ctcaacaagc aagcgggaac ctgcagagca tacttggccg 2846641 gcgtggaaaa atacagcgtt taaggcctga tcaaccgcaa cttctaaatc cgcgtccttg 2846701 aaaacaatat ttgggttttt cccgccaagt tcaagggcga tttttttgac gtttccgctt 2846761 gccgcccgca tgattttttt gcctgtttca attccgcccg taaatgaaat caaatcgacg 2846821 tctttgttta cggcaagctc gtcgcccact gtggctcccg gtccaagaac aagatttgcg 2846881 acaccttttg gaacaccggc ttcttccatc agcttaaaga ctttgattgt cgtcagcggc 2846941 gtaatctcac tcggcttcat gacgattgtg tttcctgcgg ccagtgcagg ggcgattttc 2847001 cagctcgctt gaaggagcgg ataattccat ggagtgatct ggccgcaaac cccgattggc 2847061 tccctaataa ttttgctttc tgaatcagga atcggagatg aaatgatctc tccgccatct 2847121 ttgtctgcca agccggcgta atattgaaaa acattggcga tatcgtccat atcggccttg 2847181 ctttcttcga gtgtttttcc tgtatcaaga gattcaagct cagccagctc ctcaagatcg 2847241 cgtctgatta attccgcaat tttcagaaca atttttccgc gttcaagccc ggatagcgat 2847301 gaccattctc ctttgtcaaa tgctctacgt gcggctgcga ttgctttgat ggcgtcctct 2847361 cgccctccct cgcttacagt tgcaatttct tcttgattaa atgggttgat aatactgcgg 2847421 atctgttctt tttcggcact gatccattct ccgtcaatga ataatgtttg actcatataa 2847481 gcctccttga cgtaaataaa gtttgttaaa taaaaattta atgtttttaa caaccttaat 2847541 ctaacatatg gtttttaaac tgtcaaagtc ccattttgat ttttcttttt gacttttcct 2847601 catgtttcgt taagataaag aacataaaga aataacttaa cgaatttaat tttctaaagg 2847661 aaaagagggt cagtatggat gaaaatccag aatttgcagc tatagaacag gctcgggatc 2847721 ttgttattga ctccattgct gaaacgatgg atctttacgg aattacccgc agtgtcggga 2847781 ttttatatgg gacgatgtat atgagggatg agatgacgct tgacgaaatg cgtgaggagt 2847841 tgcaaatgag caaaccaagc atgagcactg gcgtcaaaaa gcttcaagac ttaaatgtag 2847901 tgaaaaaaac atttcaccgg ggcatccgca agcatacatt tgtggctgag aaggatttct 2847961 ttaaattttt cacaaatttc tttccaccta aatgggagcg ggaggttcaa gtgaatgtaa 2848021 cagcgatcga ggaagctcaa gctgatttac aaaaggtttt atgcaaggaa gatctcgatg 2848081 aggatatcaa aaatgaagca ctgcagttat atgatcagct ggaaagctct aaagcttact 2848141 atgactggct gaaacggctt gctgaatcgg tgcagaccgg agaaattttt aaatttatac 2848201 cggtcgaaac aaagtaaagc agaaaacgcc tgggaaacta ggcgtttttt tgatgtaact 2848261 actacaaatt tgaaaaatac gggaaaaaca ccccatttac ttccaaaata tttgatggta 2848321 attttatgta ggtaaaattt gtatttggcc tttcagagga ggtgaaaagc gggcaggcct 2848381 gtttaattta tcatttttta gggggaattt tgttatgaaa cgcaaattat tatcttcttt 2848441 ggcaattagt gcattaagtc tcgggttact cgtttctgca cctacagctt ctttcgcggc 2848501 tgaatctaca tcaactaaag ctcatactga atccactatg agaacacagt ctacagcttc 2848561 attgttcgca acaatcactg gcgccagcaa aacggaatgg tctttctcag atatcgaatt 2848621 gacttaccgt ccaaacacgc ttctcagcct tggcgttatg gagtttacat tgccaagcgg 2848681 atttactgca aacacgaaag acacattgaa cggaaatgcc ttgcgtacaa cacagatcct 2848741 caataacggg aaaacagtaa gagttccttt ggcacttgat ttgttaggag ctggcgaatt 2848801 caaattaaaa ctgaataaca aaacacttcc tgccgctggt acatatactt tccgtgcgga 2848861 gaataaatca ttaagcatcg gaaataaatt ttacgcagaa gccagcattg acgtggctaa 2848921 gcgcagcact cctccgactc agccttgcgg ttgcaactaa tgtaaaagac cggttaacgc 2848981 cggtcttttt tgcgttttac cctccccttt ttctctaatc cccgttatct tttttctggt 2849041 ttaaaattta aattgacaaa cactagaaac aggagtaaat tcttgagtgt tcaatttcat 2849101 acagtctctt ttaccgctta atcaaacacg aacgggggaa ccaacgattg gctgttttat 2849161 taacagcctt ggggtgaatc ttactaagta agagggggta ctctgaatcc ctaatccgac 2849221 agctaacctc gtaggcgtat acagagagga ggtctattat cggccattct ttgcaatggt 2849281 cttttttgtt tcaaaaacgt taattcacta agggagatat gaacattggg aagaattaaa 2849341 aataagcaat ttgccgtgat cgggctgggc cggtttggcg gcagcatttg taaagaactt 2849401 catagaatgg ggcatgaggt ccttgcggtt gatatcaacg aagaaaaggt caatgcatat 2849461 gcttcttacg ccactcatgc ggtaattgcc aacgccaccg aagaaaacga attgctttca 2849521 ttaggaatac gcaattttga atatgtgatt gttgccatcg gagcaaatat tcaagcgagt 2849581 acgctgacca ccctattatt aaaggagctt gatattccaa atatttgggt gaaggctcaa 2849641 aactattatc atcacaaggt gcttgaaaaa ataggcgctg accgcattat tcatcctgaa 2849701 aaagatatgg gggttaaaat cgcacaaagc ctttcagacg aaaatgtttt gaattacatt 2849761 gatctatctg atgaatacag tattgtcgag ctgctggcta cgcgcaagct tgattcaaaa 2849821 tcgattattg acctgaatgt aagagcaaag tacggctgca cgatcctggc cattaaacat 2849881 catggagata tctgtctttc ccccgcgcct gaagacatca ttcgcgagca agattgcctg 2849941 gtgatcatgg gccacaaaaa ggatattaaa cgttttgaaa acgaagggat gtagacaaag 2850001 gtgacacttc aaaaggataa agtgatcaaa tgggttcggt ttacaccgcc tcaagtgctt 2850061 gccattggtt ttttccttac cattatcatc ggggctgtcc tattaatgct tccgatttcc 2850121 actacgaagc cattgtcatg gatagatgcc ctttttactg cggcttccgc tacaactgtt 2850181 acagggcttg ctgttgtcga taccggcact caatttacgg tattcgggca aacagtaatt 2850241 atggggctga ttcagattgg cgggcttgga tttatgacat ttgcggtctt gatcgtcatg 2850301 atattaggaa aaaaaatcgg cttaaaagaa cgaatgctcg tccaggaagc cttaaaccag 2850361 ccgacaatcg gcggtgtcat tggccttgtc aaagtcctgt ttctgttttc gatcagtatt 2850421 gaattgatag cagcactcat tttatccatc cggcttgtac ctcaatacgg ctggtcatcc 2850481 ggcttgtttg caagtttgtt tcacgcaata tctgctttta acaatgccgg gttttcgttg 2850541 tggcctgata atttgatgag ctacgttggc gatcctacag tgaacctcgt gattactttc 2850601 ttatttatta caggagggat cggatttacg gttctgtttg atgtgatgaa aaatcggcgt 2850661 tttaaaactt tttctttaca tacaaagctc atgcttacag gaacgctgat gttgaatgcg 2850721 atcgctatgc ttacggtctt tattttagaa tacagcaacc ccggcacgct cggccacctg 2850781 catatagtgg ataaactgtg ggcctcctat tttcaggcag tgacgccgag aaccgcaggg 2850841 ttcaattctc tagattttgg aagcatgaga gaaggaacaa ttgtatttac tttattattg 2850901 atgtttatcg gagcaggaag cgcatcaacg gcgagcggca ttaagctgac tacgttcatc 2850961 gtgattttaa catctgttat tgcttacttg agaggtaaaa aagaaacggt tattttccgc 2851021 cgttccatca aatatccgat tatcattaaa gctttagctg tgagcgtcac cagtttgttc 2851081 atcgtgtttt tagggatttt cgccctgacg atcacagaac aagcgccatt tcttcaaatt 2851141 gtgtttgaaa ccttttccgc attcggaact gtcggcctta cgatggggct tactcctgaa 2851201 ctgacaacag ctggcaagtg tatcatcatt gtcatcatgt ttatcggaag aattggtcct 2851261 ttaacgttcg tgttttcatt cgcaaaaaca gagcaatcaa atatccgtta tcctgatggc 2851321 gaagtgttta cagggtgata tcaaaaaaat ccggcgtgca gtcgccggat tttttatgat 2851381 tcgatatgag attgattttg tcttttttcc tgttccgcga tgatttcgtt atcctccgcg 2851441 ttatcacggg tcactttttg cgtaagaatc gcaccaactg ctacaagtat cataacagcg 2851501 atgtaataac ctttttcatt gagttccaga ttatcagcat tatagagtcc gatactaaac 2851561 aaaaatactc ccgcaaaaaa agtaaaataa gctagtactg taaaggcaac cgtgtttctg 2851621 cgtctatatt tctgcacctt tgttccctcc cgaaagcata gttaaaaagt gataacttcc 2851681 gtggaatatt atacctcaaa ttccccggaa tggaacaaag aattaaaaat accagtaaaa 2851741 agggcttagg ttgcctcctt tatttcaaca gctgaatcat caatccagcc gataagttta 2851801 tcattgattt ggaattggta ccatacagac tggcctttct gttttttaga cacaaccttt 2851861 atgtctttgc cgacgtaaga ttgggcagag gtaagcctta tggaccgatc atcagtagaa 2851921 ggcttggacc atacgtcttg aacggcactg tctttaatag aggcgtttaa atccacagat 2851981 ttgagggatg gatttacctc atcgtactca tctaaatcgt atttttccac aatagcgctg 2852041 attttgtcag cgtagtcagg gtctgtagca tatcctgatg tttgcagggc ggttgccgct 2852101 tccttataat tccctgcctc aagcaccggt ttatacttct ttttattcca cgatgtgcca 2852161 cggacgaaca attgggcgtg atcatccata gattcaaaaa acgtgctgta ttttcgaaac 2852221 ttcgcgcgaa tggtttttct tttccctttt tcaacttcgt ccgtttccat cgtgacatga 2852281 tggcctttat aattcccttt tacgccaaaa aggttgttgg ccttagcagc cagttcactg 2852341 ttcccccagt ccgattcgag aatggcctga gcaattgtga tgctggggag aacatggtat 2852401 ttttcataca aaatttgggc atgtccggac agactgtcta taaatacttg ctgttcatcg 2852461 atttcttcag tttctttgga tatttcaatc ggttttgata aagttgtcgc taaaacaaac 2852521 agagctagcg gaatcgatac aaggaaaaat agtgaaatca agagtttacg ttttttaagt 2852581 tttttacggg ccatgaaaac cttccttcga attaaaagat tacgaatgta aaagaatcta 2852641 ccttttagaa ttttacttgc acttctaata tttttcaatt ctttagggat aaagttggga 2852701 aaagattgca aaataaaaac cttttcgctc aatgaaaagg tttttaccat gtttctattt 2852761 ttgtaaattt ctgagtgcat tccgatattc cgtatcattt attactttat atgatttgac 2852821 agttgccttc gacaaacctt gtgctgagac ggccggtttt tccggagctg ttttcgcttt 2852881 atcatgtggt ttatgtgcca gcttgtgccc cattccagtg gcattcatac aaaatgacag 2852941 gcagacgagc agcacgctaa ggataaaaga aatgaagaag agatcatgat aagcagtcat 2853001 catagaatcc tgtaccgaac cgctttgtct ggcagcatct tttttcgtga aaaagccgat 2853061 gagaatggga actcccatat agacaaacaa tcttaaaaac tgaacagctg tcattctctt 2853121 gaccaaatca ggcagcgggc ctcccatggc agctcccatc agccctgcgg cgactgtcag 2853181 gcctgttccc gctgcaagca tgataaacag tgccgcgaac atataaagag atgatcgatc 2853241 ctgtatatgc agccattgaa aattcacaaa aacgagaatg agtccgccga taataccgag 2853301 catccctggt ccgactttat cgtataacag agcgctcaaa atggccgcga tcgccactcc 2853361 gattaaaaga gtcaagctta aaagaatgag atgctcctga gaaatatcat acatttgacg 2853421 gagcaagcct tgaaaagcag aaaggctgac agctaccgtt atcgtccctg cagctatgat 2853481 caataagccg agcaccggtt ttggcagcag catcagttta atagatatga aggggttttt 2853541 cactttatat tccacaatca atagaccaat gagcaaacat aacgtcaccc cgaaaccaat 2853601 ccatacataa cccgatgaca gcccccattt ttgcagaaaa atgaatgaaa ccgctgaggc 2853661 tgcggcaagg aagacagata aaagaattcc cgcacgatca agcggctgtt cttgatccgc 2853721 cgctccgtga tgctcatcat gaagaaagaa atagctcacc gcgacaccga tcagggacaa 2853781 ggtgccaaag atgaaaaaca gccatctcca atgcccgcag cttgttgcaa tggttcccag 2853841 gattgtaccg atgataacag aaccatagaa tcccccgatc agcacaagca gtgcatagtt 2853901 cctgcgttca atcgggaatg acagtacaag cattggaatc ataatcatca gcatgacgcc 2853961 tgttgccgcc ccttgtaaaa agcgccctgc cgccatcaat gcaatatcgc ctgaacatgc 2854021 gatgagcagt gagcctagta taaagacagg taatgaagcc agatagacgg gacgagcacc 2854081 gaattttttc ctcagcagcg gtcctgccgg aactaacaag gcaaaggcca tattgccgat 2854141 caatatcgga tttactgatg taaagacact tgttccaacc gttttctgaa caaggccttg 2854201 aactgacgac aatgccgtgt tagacatcaa tcccggcccg accgctaaga cggcgagcaa 2854261 agaaatcacc caatagtgtt ttgtcttcat gttgtcatcc cttcctatat gaatacatgc 2854321 gaaacacatc attttttgaa aacaaaagaa gctaatagat tttgcatacc attagctttc 2854381 attctaatat tctccctttc aggggaaatg atattatttt attataatta tgtgaatgaa 2854441 tgagcatata atcaaatatt atttcaaatc gattgtgttt tgtcaatgga gtaaatttca 2854501 agcacaacat agaaagcttg aaagcttttc cccgatattg tgtctagaac tgcacttatg 2854561 aatccctgct cgttccctca agcgaattaa agcaggccgt tttaatcctt tcaatccact 2854621 attccaacta ataaactcaa ataagttggt gataagacaa cattttaccc ccacattttt 2854681 ttgtgttcac tgggcgtttg ccgcctctaa attgtatatg ggtaaatacc atgaattaac 2854741 ctatgaaata ccaatgtaag ggaggcaaaa acgaatggaa ctgtatgagt gtatccaaga 2854801 catttttggc ggcttgaaaa atccatcggt taaagattta gcaacgtctt taaaacaaat 2854861 tccaaacgca gcaaaattga gtcaaccgta tattaaggaa ccagaccagt acgcttacgg 2854921 ccgaaatgcc atctatcgaa ataatgaatt ggaaattatc gtgattaaca ttccgccaaa 2854981 caaggagaca acagtacacg atcatggtca atccattggt tgtgcaatgg tgttagaagg 2855041 aaagcttctt aattctattt atcgttcaac cggcgaacac gcagaactct ccaattcata 2855101 ctttgtccac gaaggagaat gccttatttc aaccaaaggt ttaattcaca aaatgtccaa 2855161 tccaacatct gaacgaatgg tgtctcttca tgtctactcc cctcctttgg aagacatgac 2855221 ggtctttgag gaacaaaagg aggtattgga aaattcatga ttgacagata aactgctcac 2855281 tttgacttca ctcaactgga ggattcagag aatgaaacct tttcctcaaa acaaaaaaac 2855341 ccttatcgaa taagggttta aaggtatgga gccaaggggg ctcgaacccc tgacctctac 2855401 gctgccagcg tagcgctctc ccagctgagc tatggccccg tatgtaacgt catgtttatt 2855461 atagatgatt ttattttgaa aaacaagctg tttcctcttg aattgacaga aaaaataagg 2855521 ctcggaaaag agccttattt ttcgacttac atcatgatca aaagtaaaat cacaccgaga 2855581 ataattcgat agattgcaaa tgggacaagt ttgattttgt taatcagcct taagaagaaa 2855641 cggacgacaa acagtgcgac cacaaaggca cagataaagc cgacgatgaa aaacggcatc 2855701 agatccgaac ttaagctgtc ccaatgcttc acgaggctta gaaagctggc tcccatcatg 2855761 atcggcatcg ccataataaa cgtaaagtcg gctgcagctc ggtggtttaa tccgagaata 2855821 acaccgccgg aaatggttga acccgaacgc gagaaaccag gccaaaggga aagacattgg 2855881 aataagccga cggctatcgc ctgtttatag gaaatgcggt cgagtgtgtc tgtcgctgtt 2855941 ttccgtttat tgacccagtc agcaaaaagc atgaggattg ccccggcaat taaaccgatg 2856001 gccacagttt taacggaaaa taaatattca tcaatgtaat cttcaaacaa aaagccgaga 2856061 acagctgcag gcacgagtcc gacggcaatt tgggcaatgc ttaatttatg tccctgctcc 2856121 tggtcgcttg taatattttt tttcaagccc agtaaattta aaattcggtc tttaaacacg 2856181 atagctactg ctaaaatgga gcctagctga ataaccacct tgaatgagtt agcagcttct 2856241 tctgacatca gattacttga ttttagccag atgtcgtcta ctatgatcat atgtcctgtc 2856301 gaagaaaccg gcgcgtactc tgttaatcct tctacgattc ctaaaatggc ggctacaaac 2856361 aattcccata gagtcatgat tttgattctc cccattagac atttattttt ttacataacg 2856421 ggagcttccc ataaatggaa agcccgtctt atataactat aaacgaaaat cacactttat 2856481 gccccggcgt attttcattt ttttcttcat cgtataaatg tgactgcatt ttaaaccagt 2856541 caaataaatg tgtcgtaatg actttggcaa ccgcatagcc gggaatcgca agaatgattc 2856601 caacaacgcc aaacagcttg ccggctgtta acagcagaaa aataatcgta atcggatgga 2856661 tgtgaaggtt ttttcccata atttgcggag agatcagctt cccttcaatc agctgaacaa 2856721 tcgtccaaac gatcaccagc ttaagcagca tgagcggcga tgtcactatg gcaatgataa 2856781 tcgcaggcgt aatggcaatc gttggcccta aatatggaac gatgcttgtg caagccgcaa 2856841 tgactgcaag caatgaagca taatccagcc cgataatcaa ataaccgata aacagcaaaa 2856901 acccgataca gaagctgaca atgatctggc ctctgatata agagcttaac cgatgattca 2856961 tttcgcttaa gactgtatat gtctgttctt tcaatcgagt cggcacaaac ttcagtatgt 2857021 agaccggtaa ttttcttccg tcttttagca aataaaatag aataaacgga accgtgacga 2857081 tcgaaatgat aatctcagtc agtgcgccga taaaattccc aacaccggta aaggtgctgt 2857141 tcacgatcgt cgctgcctga tccgaaacct ttgtagcaag atcagatata ttaatgttca 2857201 tcgtttgctg ggcctgattg acgaagttgc tgccaatcag ctgtttcgtc tgattttcta 2857261 cgacgtccac atatctcggg atattgtcaa tcaaactcat aatttgttct tttaagaagg 2857321 gaatgatcga cacgatcgtg atcgtgatca gcccgataac caataggtat agcagcaata 2857381 tagaatagat tcttcttatt cttcttctct ccagaaaatc gacgactggg tttaacagat 2857441 aaaaaacaat gcctgtcaaa ataatcggaa gtgatatcgt tttgagcaga acaataatcg 2857501 gggtgaaaat aaatgatgtt tttgtaaata ctagaatatt taaaccaatc agcagcagca 2857561 caagcaaaaa taaaacaaac ttattatcca agaagaatcg cttgaatctg ccgctccatg 2857621 tttgcaacgt ctccactatc gttcctccgt catacatagt ttaattaaat tgtacactat 2857681 cgtccctata atgaaaaata aaaaccgtta attgctggaa aagctttctc ggttttaaca 2857741 ttctatttat atctatcatg tgattttgtt ctttttaagc tataatttag ctatatcatg 2857801 caaaaggagc gatacgagtg atacgttttg caataatagg aaccaactgg attacagacc 2857861 gctttcttga gtcagcagcg gatatcgaag attttcagct gactgctgtt tattcaagat 2857921 cggctgaacg cgctggcgag tttgctgcta aacacaacgc tgcgcatgcc ttctcagacc 2857981 ttcaggaaat ggcggcgagc gattgctttg atgccgtata catagcgagc ccgaacgctc 2858041 ttcacaagga acaagccgtt ctctttatga accatggcaa gcatgtgctt tgtgagaagc 2858101 cgtttgcttc gaatacaaaa gaaacagaag agatgatctc agcggctaag gcaaacggcg 2858161 ttgttctcat ggaagcaatg aagaccactt tcctgccgaa tttcaaagaa ctgaaaaaac 2858221 acctgcataa aatcggcact gtccgcagat ttaccgcaag ctactgccag tattcctcac 2858281 gatatgacgc gttcagaagc ggaactgttt tgaatgcgtt tcagcctgag ctttccaatg 2858341 ggtcattaat ggatattggc gtctattgta tttatccggc tgttgtgttg tttggcgcgc 2858401 cgaaggatgt aaaagcaaac ggatatgctt tatcctccgg agtggacgga gaaggaactg 2858461 tcattctgtc ttacgacggg ttcgaagctg ttctgatgca ttccaaaatc tctacttcct 2858521 atgccccggc tgaaatccag ggtgaagacg ggacgattgt aatcgatacg attcaccggc 2858581 ctgaacgtgt tgaaatccgc taccgggacg gccgccttga aaacatcgcg atccctgatc 2858641 ctaaaccggc gatgttctat gaagcagaag aatttgtcac gcttataaaa gagaataagc 2858701 tggaatctga agaaaataca tttgaacggt ctttgaccac cgcaaaaatt atggaagaag 2858761 caagaaagca aatggggatt gtataccctg ctgatcaagc ttaaaaaaat ccgcccgcgt 2858821 gcaaatgccg cggcggattt tttattagac aatcggagaa gatgccttcc tttttaaaag 2858881 cacctgttgc tcatattctt tgatgtcata aagccatgcc tcttttaccg gaacgcccat 2858941 ttgctcacag taggaatccc agatggctcc gaaaggatat gttttgaatt cctccatcag 2859001 ggccagcctt tctgtatagc ggccctcttc ctgcaattgt tttaaatatc cgttcgggag 2859061 aagcagggca tacaataaag ctttgatcat atttctcgtt ccgatggtcc aggcggctac 2859121 acggttaatg ctggcatcga aaaaatccag accgatggct accttctcaa gagcatgatt 2859181 tcgtacaatt tcaagagcga tttctctcaa ttcatcatcc aaaaccacta catggtcgct 2859241 atcccaacga acaggccgcg atacgtgcaa ggcaagcttg tctgtgtaaa gcagcatgga 2859301 cgagatcttg tttgataccg tctcagtcgg atggaaatgg cctgtatcaa gtaaacaaag 2859361 cttatgattc gtcaaagcat aagctaaata aaattcatga gatccgacaa catatgattc 2859421 ggagccaagc ccgaacagct tgctctcgat tgaatcaaga ttatgttgtt cactgatctc 2859481 ctctgagaag atccgatcca gtgattcttt tagtctttta cgcggtgtca gcctatcact 2859541 cgggatatcc ttatagccgt cgggaatcca aatattcgtc aagcaaggtg ttcctaattc 2859601 tttcccgaag tattccccga tacggcggca agcgatgcaa tgcctgatcc aaaattctct 2859661 gatgtccgga tcagggtgtg aaagggtgag tccgtcagcc gctttctcat gcgaaaacaa 2859721 ggttggatta aaatctaaac cgagaccaag gttttttgcc catttcaccc agttttcaaa 2859781 atgctgcggc ttcaattcgt cacgttctac cgcttccctg tttgtttctg cgtatatcgc 2859841 atgcaggttt acgcggtgct ttccaggaat gagagaaaga gccttctcca aatctcttct 2859901 taattcttca ggagtttgcg cttttccggg ataattgccg gtcacgtcaa ttccgcctga 2859961 aagctcgccc ttatttactt caaagccttc aatgtcgtca ccctgccagc agtggatcga 2860021 aatgggcact tgctctaatt gccgaagcgc ctcttcaaca tcaattcccc atttttcata 2860081 tgcctgtttt gcactgtcat aattggcttt tatggtcata cggctctctc cctttatcag 2860141 tttttcaatc caaataaaaa acttccttta gatctatcgc aacaggactg aaatccgaat 2860201 ttgttttcat taatggcgcc atcgatttcc accatctttg gcaaacttcc gtgtccgcca 2860261 tctttctcca tttctcttca tcctctattt ctaaatatgc aaaaagcctg cctgtttcct 2860321 cgtctagaaa aatggaataa tggtgtgctc catgagcttt gagtgcttct gccatctcag 2860381 gccaaatgtc atcatgccgc tgtttgtatt cttcgtactt gtcttgatgg acaaacatga 2860441 tactggcttt tcttttcaaa ccttttcacc tcttcatcat ttagatagcg ctttcaaaac 2860501 agtttgctga aatgactgaa tgatcgtgct tctatcaatg tctttaggtg taaacacttt 2860561 gatcggaaag gaatttctga cgacttgccg ggcttctttt atgtctttga cttctttggc 2860621 agcaatcatt tgcatcaaaa gatttccggt ggcagttgcc tctatcggcc ctgcatatac 2860681 cgcttttcca ctcatgtctg ccgttaattg atttaagaaa tcattccggg ctccgccgcc 2860741 gatgatatga aattgctcga tcggtttttc tgtgattgtt tcgagctctt tgatggctat 2860801 cgcatagatg atggctaaat tgctgtagat gcagcaggca agttcgcctg cagtacgggg 2860861 aatcttttgg cgggtttgtc tgcaataatg ttgtatttcc tttatcatgt tttctggatt 2860921 caggaaacgt ttatcattta agtttataaa ttgctggaat ggttctgttt ttttggcttc 2860981 ttctgcaagc tgctgaaaag aataatctgc ttgtagctgc tgtttgactt cttgtatcac 2861041 ccacatgccg ataatgtttt tgagaaagcg aatggtgttg tttgcgccgc gttcatttgt 2861101 atagttgttt tctaaagcaa gatcagttat tatcggtgtt ttgttttcaa ccccgattaa 2861161 cgaccatgtt ccgctgctga tatacgccca gccatcattt acgcctggcg ccgcaatgac 2861221 ggccgaggcc gtatcatgtg ttgcgactgt catcaccttg cacgccggga gatcataatc 2861281 cgggaaccac tcatttctta gcttcccgag ttcacacccc ggttcagtga gcggcgcaaa 2861341 ttgctgttcc agaacagaca cggcttcaag caattcagga tcaagatttc ccgttgagac 2861401 gtttaaaagc tgtgttgtgg acacgtttgt gatttccgtt acagcttttc cggttaaaca 2861461 atagcctaaa taatcaggaa tcatcataat tttgtctgtc tttttcagca gctcacggtc 2861521 ttcttcaaac aattgataga tcgtgttgaa aggctgaaat tgtattcctg ttttttgata 2861581 aattgcggct tttgagaggg tatgttccag tttgtctatt gtgtgatctg ttcttctatc 2861641 acggtaggag attgcttccc gcaaccgatc gcctttttcg tccagtaaga cataatcgac 2861701 tgcccatgta tcaatgccta cggtgcagtg ttcataccca agcgtcttta ctttttgcag 2861761 tccttgcagg atttgtttta gcaaatgatc aatatcccat aagcaatgcc cgtctctttg 2861821 actgaaaccg ttagcgaacc tgtgaatctc ttgtatgtca agcttccctt cattcagttc 2861881 acctaccatg attctcccgc ttgatgcgcc tacatcaatg gcagtataaa tcatcctttc 2861941 accctctctt cgaaagagga acagctgtca ccttcacctt tttgtcctca agagctttta 2862001 ccgatgccgg atcaagtcca gaatccgtaa taaggcggct gacatcttgc agcgaggcga 2862061 tatgtgaaaa ctcgcggttc ccccatttgc ttgaatcggc catcaaaatg gtctggtccg 2862121 acctttcgat catccgtttt ttgagcagcg cctgccactc atttgaatca ctcatcccgt 2862181 tgtgtacgtc aaatccctta catgacagaa aggttttatt gacatgatag gtctcaagtg 2862241 aacgctctgc taacgggccg gcaaatgata atgatttttc cagcaaaatg ccgcctgttg 2862301 aaatgactga tatgttttct ttattgctga gttcaatagc tgctttcatt gagtttgtaa 2862361 tcacggtgag ctcaatgtca gggagtattt ttgccatgta ccaagcggtt gtgcttgcat 2862421 cgagaatgat tcggtctccg ctttttacat atttggccgc ttcgtgagcg atggcttttt 2862481 tttcgatgac attcgtgatt tcccgttcag aaaaatgaat ttctgattcc ttctgctgaa 2862541 tactgaccgc tcctccgtgg ctccggctca gtttatgttc tttttcaagc ttttcaagat 2862601 cacgccgaat ggtttcctct gtgactgaaa aaatgtcact taattcggaa acgcggatgc 2862661 ttgaacgcat atttactatt tccactattt tttgctgccg ttctgctact agcatcggta 2862721 acgcccttcc tcatatcgta gtccgtctta tatttttatc atagcatata tctaacgcgt 2862781 aaaagcagca gggacgccgc cgtctaccgt gatcatgcag cccgttgttt tttcggcttt 2862841 ggaagaagcg aagaatgcaa tggcttcggc aatatcctcc gggtaaatat tgacgagcaa 2862901 tgctgtccgt ttccggtaat gttcctccag ctgatccggt tcaatcccgt acgccgcggc 2862961 tcgttcctca cgccagcttg aaccccagat tgccgatcct tgaagaactg catcaggcaa 2863021 aacggagttg accctaatgc cgaattctcc gccttctgct gcgatgcatc ttgctaaatg 2863081 ggtttcaagc gccttaacag agctgtaggc agaggcgttt tttcccgcat aaactgaatt 2863141 tttcgatccg acaaatacca tgcttccgcc tctattttga tgtttcatct gtttaaacgc 2863201 ttcacgggct acaaggaaat agcctgttcc taaaacattc atattaagat tccattcttt 2863261 tagacttgtt tcgtcaaatg ggcttgatgt ggccagcccg gcattattga cgacgatatc 2863321 aatgccgccg taagcaagcg ccgctcgttc aaaagctgac tgtacgtctt cctcctttgt 2863381 cacatccatt ttgacagcca ttgcccgtcc ttttccgtat gcatcgttta tttccccggc 2863441 aattttctgt gcgccttcta tattcagatc agctacgatc acgtgccctc cctcagctgc 2863501 aaatcggcgg catgccgcac tgccgattcc gccggctcct ccagttatca gcgctacttt 2863561 tcgggaaaat tctgcttccg gcggggccag cgtgagttta tatagttcga gcggccaata 2863621 ttcgacatgg taggactcat tttcatgtaa agaaacaaat tgccccagag cggttgctcc 2863681 tttcattacg gcgatggccc tccgatataa agccccgctt actttagaca tcgcataact 2863741 ttttcctgta ttcaccattc cgattccagg aatcaatatc acccgcgggg cggattcaaa 2863801 gatttgatcc ccatcctgct gattgcgtgt aaagtaagcc tgatactctg atgtaaaggt 2863861 ctcgactcct gacttgatca gatctgcaag cttgtgcaca tcttgagttt ccggattcca 2863921 atcaatgtac agcggaaccc gttttgtgtg aacaaggtga tccgggcatg ccgcaccgat 2863981 ttgcgaaagt gctggcgctt ggacactgtt tacaaattcc aagacatcgt catgatcatc 2864041 ataggaaagg atcattttct tttcttcact tactgctcct ctgatcacag gcatgatgcc 2864101 tgccaagatt tgttttcttt tatcctccgg cagcggctga taccttttgc ctccgaatac 2864161 ctcatgctga ttgatacgat cgttaatata ctgctcggct tcttgaatga tggatatcgt 2864221 tttttgataa catgtttcag acgtctctcc ccaagtgact aagccgtgtt tctccattaa 2864281 tacaagctcg gcgtgggggt tgtttgctac gccttcagcg atcattttag acaaagtaaa 2864341 tccaggacgg acgtatggca cccatacaaa ccgatttccg taaatgtctt cagcgatttg 2864401 ttttccatta tccgcacagc atatgctgat aatcgcatct ggatgggtat ggtcaacatg 2864461 tttgtatggc agaaaagcgt gtaatagcgt ttcaattgaa gggcggggat gtttgctgtc 2864521 tatcatacaa tgagacaggt agtctaccat ttcttcatcg ggcatttggt cccttttaat 2864581 cagcgggcgg atatcatcta atttcaaacc ggaaaagtta tgcgctttca ttgttgccaa 2864641 atccgatccg cttcctttta cccacatgac ttctatttca cggcctctaa aatccttttc 2864701 cgttgttttc atagatgtat tccccccgcc ccagttgcag acagtgcggt ctgacccgat 2864761 cagattggac ctgtacacca attcctctac acctttaggt agctgtgcag ctcgctctga 2864821 atcccatata tgtttcacca tatttgatat tcctccatac ccttttattt gtatccgttt 2864881 tcattatata tgatttctgt ttgtttttga atcgtttttg tttatttttg ctttttaaca 2864941 aaaaaagaaa gcagcagata tgccgctttc tcgtttcatt atgattctat tttaaatttc 2865001 ttcgtaatgt cctgaagttc ttccgccatg tttgccaacg tttccgctga agagctgatt 2865061 tcttccatgg acgcaagctg ttcttccgcc gaagctgcga tatcctgaat gcctgctgag 2865121 ctttctttcg ccactgcaga aatatcttca acagcacttg acacttcctg tgatccggct 2865181 gacagttgtt caaccgtcgc gttcaagttt tgcaattcgc cggaaatttg ggttgtcatc 2865241 tcatagattt gtttaaagct ttccgctgtt tgatccgtaa tctgcaagcc ttctttcact 2865301 tcatgattca cggattggaa cattgaaagt gaggtgctga tttccctgac aatctcttga 2865361 attaatcctt caatttcctt ggcggagtct gctgattgta cagcaagttt tctaacctct 2865421 tccgcaacta ctgagaaacc tcttccgtat tctcccgctc ttgccgcctc aatcgcagca 2865481 tttaatgcaa gcaggttggt ttgatcagca atgccgttaa tcacattcaa gatgcttgtg 2865541 atgtcttgcg attttgtttc aaggcccttc acaaccgctt ccgctttttg aacggattgg 2865601 tcaattgttt tcatctggcc gactgtatgc tccaccagct tttctccgct gcccgctgcc 2865661 tcagaggact gaatcgatga tttcgtaatg gttgaagagg cttgagccac ttttgaaatc 2865721 ccctcgttca tttgagaaag atgatttgag cttgtttcca gtttctcgct ttgtgcctcg 2865781 ttgccatctg agaactgttc gatggcaagt gtaatatgtt cagttgcctt gcttgtttgg 2865841 gctgcgcttg ctgtcagctc ctcagaagat gaagcgacgt tttctacaga cgtttgaata 2865901 acgcctatta cagaacgcaa tgatgcagac atttcattaa agctttcgcc aagctggcca 2865961 aactcgtttt tcgagtgaat gtcaatgact tctgtgagat ctccgctgct gatttttgca 2866021 gacgttgaga caagttttct taacggcttg gtgatggcac ggataatata gagtatgagt 2866081 atgccgccga ttactattga cacgcataga atgataaccg cagtgttcag caccgggctt 2866141 gaagcatctt gcaattcact gacaaaatat gtgcccgcga ttttccagcc agtcagttta 2866201 tttgtcgtaa aggccatttt cttttctttg ccttcgaatg tatattcaaa tgagccttct 2866261 tttttggaat atacttggtt tgtccaatcg ccggaaccgg ttgtccccgg cttaatggtc 2866321 ggatgggcga tatatttttt gttgcctgtc gtaataaatg caaagccttc ttttccgatt 2866381 ttgattcttt ttgatgcagt aagcacttca tccaggttta aatctagcgc tataacccct 2866441 gaaccgtctt ttaattgttt tgaaattgtg acaacgatat ctcctgtcgc ttcatcggta 2866501 tacggttctg agaaaacagc ttgtcctttt tccgcaaccg cctgtttgta ccagtcacgt 2866561 cctgtcggat cgaaaccttt cggaacaccg ctatccggat atttataaag cttcttatct 2866621 tctgaggcag catagattgc gcctacatcg tcgttaagtg tcgtgtactg cttaaatttc 2866681 tctttcagta atgttttgtt tttgcctaac aatatgtctt tatcgactgt ctcactataa 2866741 taatctattg cttttacttt atcttctaat ttattttgca gcgtactgtt tagttcttca 2866801 acatttccct tcgcactgct tatgagctct ctgtctaacg cgttccaagc tgattgataa 2866861 ctgaaatatg ctaaaacccc aaccggcaaa ataagcactg ccagaaacgc agcgattagc 2866921 ggtttgctga tcgatggctg tttgatccat tgtatgaatt ttcccattct cgttgactcc 2866981 tcctttaaga taaatctaat atcgtcaaac taggataaaa ggtttaataa aaaaactaaa 2867041 aaaaacaccc aagcgcaaca agcttgggtg ttaaggctta ttattcaatt ttaaatcgtt 2867101 tggtcatatc ccgaagctct tccgccatag aggaaagggt ctctgcagac gagctgattt 2867161 cttccatgga agctagctgc tcttcagctg acgccgcgat atcttgtata tgcgctgagc 2867221 tttcttttga aatcgatgca atgtgctcag acgctcccga aacttcttcg gagctggcag 2867281 aaagctgctg aaccgtcgca ctcatatttt gcagttcgcc ggcgatttgg ttcgtcattt 2867341 cagaaatgcg tttgaagctc atttctgttt tatctgtgat gtcaagtcct gtctgcacct 2867401 cttgattgac agattggaac atgccgagtg atgtattgat ttccttcaca atttcgatga 2867461 ttaatccttc aatctctttt gctgaatctg ctgactgtac tgccagtttt cttacttctt 2867521 ccgctacaac ggagaagccg cggccgtact cgcctgcgcg cgctgcttca attgctgcgt 2867581 ttaaggcaag caggttcgtc tggtctgcga tgccgttgat cacacgcaaa atgtttgtaa 2867641 tatctttcga tttcgtttcc aatccgcgta cgacttgctc cgcttcttta acggacttgt 2867701 caatgacatt catttggccg acggtttgat gaacaagctt gccgccttca cttgcaattt 2867761 ctgtcgattg aacagatgaa tcagtgatca cttcagaagc ttgagccata ttcgtcaacc 2867821 cgtcattcat ttgataaatg tgctctgctg ccgtttcaat gttttcgttt tgtttttcat 2867881 tgccgttaga aaattgttca atcgccaatg taatgtgctc tgttgccttg ctcgtttgcg 2867941 cagctgatgc agtcagctcc tcagaggaag cggcaacatt gtctaccgaa tcctggatgg 2868001 cgtgtatgag agaacgaagt gacgacgcca tattgttaaa gcttttgccg agctcgccca 2868061 attcatcttt tgaacggata tcaatggttt ccgtcaaatc tccctcgctg atccgcttag 2868121 aggaaccgac aagctgtttc agcggtgttg taatcgaccg aatgatcaat gtcatgacga 2868181 taatccctat gataatagct gcggccaaga caattaaagc aaggtgaagg acaggctggg 2868241 ctgcctcatg gatttcatcc aaatacatgg tgccgccgat cttccatccc gtcaacttgt 2868301 ttgtgtcaaa ggccattttt ttcttatcgc catccatggt gtattgaaaa tcgcctttat 2868361 cagcactcaa catcttatcg agccagtcgc cttttaattc agttcctgat tgttcattag 2868421 ggtgtgcgac aacttttttg tccttcgtca tgataaatgc gtagccttgt gtgccgatgt 2868481 tgactttttt ggttgttttc agcagatttt caatcgtcat gttgattgcg ataacgcctg 2868541 aaccatcttt tgtctgctgg gcgattgtca caaccatcgt atttgtcgac gcggttttat 2868601 aagggtctgt gatcacgact ttccctttat ttgcaaccgc ttttttgtac cagtcgcgtt 2868661 caaccggatt atagccgctt ggcatcggaa gatccggata gcgggtaaag tgcccttttg 2868721 tgtcacttgt ataaatggat tctacatcct tgttaatgct gatatattgt gagaatttct 2868781 ctgcaatgct tgcattgctt tttgcattgt atttctcttt tgtcagccat tcgctgaaat 2868841 aatcagcact gttttctttt tcgccgatgc tggtgttaat gatttcgttt aattgctgta 2868901 cattttccaa tgcgctcccc atcatctgtc tgtcgagtga gctgctagcc gattgatacg 2868961 caaagatcgc caatatgaca accggtatga tgaggatcga cagaaaggaa acgagaagct 2869021 tccgtgtaat tgatctttgt tttatgagtt ggagtatttt tttcatcatt catttctcct 2869081 tttttatgct acccttcata tcggctggaa atgggtaaat atatacagca aaaaagaaga 2869141 aatttaacaa aagtaactaa tttcccataa ataaatagta ttttagacct attatttgtc 2869201 tactttaaat tgttttgtca gatcacggag ttcttcagac attctttcaa gcgtcagtgc 2869261 agatgaacta atctcctcca tggatgccag ctgttcctca gctgaagcgg cgatatcttg 2869321 gatgccatcc gagctttcct tagaaatggc agtgatatca tttgaagctg cggaaatttc 2869381 ttgagctccc gctgacagct cctcaaccgt cgcattcatg ttttgcagct cggaagcaat 2869441 ttgattggtc atttgcgata tatgtttgaa gctctgttta gtttcatccg tcatgacaag 2869501 ccctgtttca acttctttgt ttacggactg aagcacgttc agtgatgtgt gaatttcttt 2869561 tactatttca ctgatcagcg attcaatttc ttttgctgag tcagccgact gtaccgcgag 2869621 ctttctcact tcctcagcga cgactgagaa gccccggccg tattcacccg ctctggcagc 2869681 ttcaatggcg gcatttaaag ccaaaagatt ggtttgatcc gcaatgccgt tgatgacacg 2869741 caaaatattc gtgatatcct ttgatttgat ctccagccct ttcaccactt gttccgctgc 2869801 ttttacggaa tggtcaattg tgttcatttg gccggctgtt ttctggacga gtgtctcccc 2869861 tttgcttgac acttcggttg aatctgcgga tgtttctgta atcactgctg cagcccgcgc 2869921 cagctctgcc aatccgtcat tcatttcatt aatttgttcg gttgtcgttt ctattttctc 2869981 gctttggctt tcactgccgt ttgaaaattg ctcgatagcc atcgtaatgt gctcagtggc 2870041 tctgcttgtc tggtctgccg atgcagtcag ctcttcagac gaggaggcaa cgtgttctac 2870101 tgagtctttg atcccgtgaa tgagcgagcg aagcgagtgt gccatatgat tgaagctctc 2870161 actcagaacg ccgagttcat cttttgaatt gatttcaatc gtttcggtta gatcgccttc 2870221 actaattttt tcagcggatg cgacaatgcg tctcaatggc tttgtgatgg atcgaatcac 2870281 aaaataaatc gccgtcattc cagctccgat ggcaatcgcc agaacgattg aagccatgat 2870341 cagaaccctg cttgcagcat cgtgaatctc gtttgcatac atcgtgccgc tgattttcca 2870401 gcctgttgtt tggcttgttg caaatgccat ttttttcttt ttgcctttgt acgtatattc 2870461 aaagtccccg cttttatcct tgtagagctt atcaacccag tcccctttta gctctgttcc 2870521 cgctttttct ccggagtagg cgatgacttt cttgttttgg ctcaaaataa aagcatagcc 2870581 ttcttttccg atattgattc ctttcgcggt agtgactaag tcatcaattt tcatatcaat 2870641 ggcgacaacg cctgacccat ccaccgtttg acgggcgatg gtgacgacca tttttcctga 2870701 tgaaatcgat tcataaggct cagtgacaat tgttttgcct ttattggcca ttgcttcttt 2870761 gtaccaatct cgttccaaag cattaaagtc gcttggcatg tcagcgtacg gataacgtgt 2870821 gaagtccccg tctttgccgc ttgaaaatac cgcagcgaca ttatcattca tttggataaa 2870881 ttgtttaaat tcctgtttca gctctgtttt ctttttatcc tgaaattttt ctgctgtagc 2870941 ccaatcgctg aaatatgcga ggcttttttc agtagtgctg attttatcat caatgatgtg 2871001 atctaatatc tgaacatttt cctttgcgct ttgcgtcatc tgtacatcaa gtgaggcaac 2871061 tgctgattga taagcgctaa ccgaaagggc ggttatcgga acaattaaga tcagcaggaa 2871121 agaaataata agtctccttg caattgatga tctgcgaata gtggtgagtg tttttttcat 2871181 ttccttttga accttctttc aataatttac aaattatatc ggcggatctt cctttaaatt 2871241 acattgaaaa tggaggaaaa aatgaaaaat agttctaaat tcacctgtta aactaggact 2871301 ttattattgt ttaccatata aaaaaacagc gctttgatag cgctgttttt cggtttttac 2871361 tcgattttaa attgtttcgt cagatcgcga agctcttctg ccatctgcgc aagagtcgtc 2871421 gctgaggaac tgatttcttc catggaagca agctgttctt cagctgatgc ggcaatgtcc 2871481 tggatgcttg ccgagctttc tttcgacacg tctgcaatgc cgctgactgc tgctgaaaca 2871541 tgctgtgaac ggtctgacag ctgctcgacg gtggaattca tcgtctgcag cttgcccgcg 2871601 atttcgtttg tcatgctgaa aatgctctgg aagctttctt ttgtattgtc tgtgacaaca 2871661 agtccggact gtacttcctg attgacctct ttaaacatgt gaagagaggt gtcgatttct 2871721 gcgacgattt cttggatcag cttttcgatt tctttcgctg aatcggctga ttggacagcc 2871781 agcttgcgca cctcctccgc tacgacagag aagccgcgtc ctgactctcc ggcacgcgcc 2871841 gcttcaatgg ctgcatttag tgcaagcaga tttgtttggt cagcgattcc gttgatgact 2871901 ctcaaaatgc ttgtgatgtc ttttgatttt ccttctaagc ctttgacaac agcttcagcc 2871961 tgctgaacag attgattaat cgagttcatt tgtccgactg tctgctgcac aaacttctca 2872021 cccgttccgg cgatttccgt tgattggata gatgcctttg taatatctga cgatgtttgt 2872081 gagacttgct ggagtccttc attcattaag ttcagctgat gagagctgga ttcaaccttt 2872141 tcgctttgct cctcgtttcc gtttgagaac tgctcaatcg ccatcgtaat atgctcggtg 2872201 gctttactcg tctgcccggc agatgcggta agctgttcgg aagatgcggc cacattgttc 2872261 accgagtcct gaatagcgct gatcagagag cggagagatt gtcccatttc attgaagctt 2872321 tccccaagct ctccaagctc atcctttgaa tggatttcga tcgtttcggt cagatccccc 2872381 ctgctgatcg ttttcgatga ttgaacaaga cgttttaacg gttttgtaat cgaacgaacg 2872441 ataaacagaa ttaaaattcc gcctgccaca atggaagcaa tcagcacaat cattcctgtt 2872501 gtcagcacag actttgaggc atccttaatt tcatccatat acattgtgcc ggctattttc 2872561 caaccagtca gttcgtttgt agtataggtc atctttttat cttcgttatt aagagtatac 2872621 tggagttcac cgctgtcatt cgcatacatt ttggctaccc agtcgcctga aagcttttct 2872681 ccagccttat ggttcttgtg ggcgacatag gttttgtttt ttgttgcaat gaaagcataa 2872741 ccttcttttc cgaccttgat ttgtttcatt tgttctaaca atttatcaat ggtaatatcc 2872801 atggcgacaa cgccagatcc gtccttcagc tcctgtgcaa tggtaatgac catgcttccg 2872861 tcactcgcag ccacgtaagg atctgtcacg acaatttcac cgccggcctt catcgcatcc 2872921 tggtaccaag gccgttgtct cgggtcgtat ccttccggca atttttcttt tggcgcttgt 2872981 acataagtgc cgttatctgc gcccccataa attctggcta ctccttgatt aatagataca 2873041 tattgtgaaa atttagcttt gatctcttct tgatttgatt tccctttgaa tgcggatctt 2873101 ttaagagatt cactgaaaaa ggtgactgct ttcgcttttt ctcccagatc atttgtaaca 2873161 gttgtattaa atgtatcgac actgtttttc gcatttccca taatttcctg atccagcttt 2873221 ccgctggcgc ttcggtaaga gctaaattct aatataagaa tagggataat gagaatcgca 2873281 ataaatgaga cgattaattt ctttgaaata gacggtttct tcagccaatt gataaaagtc 2873341 ttcatgtcac ttgctccttc aggtttgata cagtatatat cggctgctta aaaaagtttt 2873401 aaaataaaaa atggaagaag ttctttttgg ctgtcttctg cctttttaac tttcattgcc 2873461 caagctcttt gcatatctta taaaaaacaa ggggggctaa acatgattat tgtatcagga 2873521 caattgctcc gtccccagga tattgaaaat tggcagattg atcaagatct gaatccgctc 2873581 ttaaaagaga tgattgagac gcctgttcag tttgattatc attcaattgc tgaactgatg 2873641 tttgagctta aactgcggat gaatattgta gcagcggcaa agacgctgca caaaagcggg 2873701 gcgaagtttg ccactttttt aaaaacatac gggaatacaa cgtattggag ggtttcaccg 2873761 gagggcgcct tggagctgaa atacagaatg ccgccttcaa aagcgattcg ggacattgca 2873821 gagaacggcc cgttttatgc gtttgaatgc gcaaccgcaa tcgttatcat ttattacttg 2873881 gccttaatcg atacaatcgg agaagataaa ttcaatgcca gctttgacag aattatttta 2873941 tatgactggc attatgagaa attgccgata tatacggaaa caggacacca ctttttcctt 2874001 ggagattgtt tgtattttaa gaatcctgaa tttgatccgc aaaaggcgca atggagaggc 2874061 gaaaatgtga tactactggg ggaagataaa tattttgccc atggtcttgg aatcttaaac 2874121 ggaaagcaaa ttattgataa gctgaattct tttaggaaaa aaggagcctt acagtcagcc 2874181 taccttctgt ctcaggcgac cagactggat gttccgtctc ttttccgcat cgtccgctaa 2874241 aaagccccat cgcctatttt ccggacgatg gggtttcaaa tgcctttcgt tttcgataga 2874301 agggggctgt gccaaaatat tggttcgcag cccactccat tttttcaagg tcatttcttg 2874361 tcacgattgg atcctggctg ctccatttga taaagcggac aaaatagtag cctttgatag 2874421 gaaccattgt aacttttgag tgaggccagc cttcaaatac aaactcaatt ttccctcttt 2874481 ttttataaga atattgaaga atgttcatat ctgtcacctc agtttatcaa gttacgttcg 2874541 gcaaagctcg gtacgtttac atccattgat taactatccc tcatgcaggc tttccggaaa 2874601 acaaagggtg aggcgcgtgt ctctttccct cgctttttat ttcgcatatg gacgaatgcc 2874661 aagcacgcct tcattcgata aagccgcagc gtgggcgggt gtgacaagcc ctccggctat 2874721 cggcgcttgt tcagcgatca tgcttttgtc ataaaaaaca gcctattatc ccatcatttt 2874781 gatatagcat gtccgggtgc gaggcccgtc aaattcgcag aaataaatgc cctgccacgt 2874841 tccaagaata agccggccgt tttccacaat gacatgctgt gaagctccga ccgtactcga 2874901 cttcatgtgt gcagctgtat tgccctccat atggcggtcc agctcatgtt cccacggata 2874961 tacctcatca aaccttctga gcatatcttt tttgacgtcc ggatcggcat tttcattaat 2875021 tgtaatgccc gcagtcgtat gcggacagta aatcagcgct gcgccgctcg ttatacctgt 2875081 ttcttgaaga aacgcttcca cctcccgggt gatatctatc atttcatctc gtttggttgt 2875141 tttgatttgc agtgttttca gcatttgttt ctcctttcgt ttgtccgctc tcatcgctta 2875201 attcgttctg tgttcttttt tttcctgtta aaccgctctc ataaacccga taaaacaaaa 2875261 aaactccagt ctaaggctgg agtttagcac catagatata ttcttgcttc atacggcttt 2875321 aagagtactg atgtcatatg cttgtgcggc tctgtttcaa tatttgacaa gacgagtgca 2875381 tctgatgaca atggcaatcc agagtgcctg aacaacgccg gtgttcctgt cagattggcc 2875441 gcaatcagtg cagtatggct ctcgtttttc cgaagatatg caaagatttg ctgatcttcc 2875501 ggtaaaatga gctcgtatgt cccgttaata aaaacatcat atgtttggcg cagcttgatc 2875561 aagcttttgt aaaaatggta aacggatgtt ttatcgtttt tttgcgcctc ggcattcagc 2875621 catttgtaat tctcattgat tccgatccac ggtttggcct cagaaaatcc ggcgtatgga 2875681 ccagcattcc attgcatcgg cgttcgcgaa ttgtctcttc cctttttcca gacaatcttc 2875741 atcacatcct cgtgtgatgt gcctttcgct gtttttgttt catacaggcg tttcaatgcg 2875801 acatcatcat agtcctcaat agatggaaaa gccacgttcg tcatcccgag ttcctgtccc 2875861 tgataaataa acggtgtgcc tttcatgaga aaataaacag cggaaagcgc ttttgcactt 2875921 tctttcaggt acactccgtc gtctccccac acagaaactg aacggggctg gtcgtgattc 2875981 tccataaaca aagcattcca gccgatccct tccagactgt cctgccagtc agttaaaatt 2876041 cgtttaaatg caacgatatc aatactttca ttgatctcta catcccacag gccgagatgc 2876101 tcaaattgaa aaatcatgct gaatatgccg tttttttctc cagcccaatc agctgcttct 2876161 tttgcagcga cgccgtttgc ttcaccaact gtcataatcg gatagcggga aaatgtgttt 2876221 tccttcagct ctgttaacaa atccataatg ccgtcagcat tcatatgata aggaaaggaa 2876281 gggacatagt ccagtccctt tggattcggc atgtcaggaa acccttcttt tttcttaata 2876341 tgcgtaatgg catccacccg aaatccgtca attcctttat caagccacca attgatcatg 2876401 tcataaacgg cattcctcac cttttcattt tcccaattca aatcaggctg ttttttatca 2876461 aaaaggtgca gataatactg gcttgtcttt tgatcatact cccaagccgg cccgccgaaa 2876521 atgctttccc aattgttggg cgtttttccg tttttgccgt ctttccaaat ataccagtcg 2876581 cgcttttccg agtgtatgga tgaacgggat tctatgaacc atggatgttc gtcgcttgtg 2876641 tggttcacaa cgagatccat aatcagcttc atatccagat catgaatgtc accaagcagc 2876701 tcatcaaaat cttccatcgt gccaaactcg cttaatatgt tttgataatc cctgatatca 2876761 tagccattat cggcattcgg tgaatcatac agcgggcaaa tccatatgac gtcagcgccc 2876821 agctctttta tgtaagaaag cttggttctg attccttgaa tatccccgat tccgtcgcca 2876881 tttgaatctt taaaactgcg ggggtaaatt tggtaaacta cggcttcctt ccaccaagcc 2876941 tttttcatac agccactcct tcccagtgta ccgttcttat atatcctatg tagaaaaagg 2877001 tctttacagc attgcttttt aagaaatgac ttgatgacac aaaaaacagc cgtttgttcc 2877061 ccggctgttt tttatcaaaa atcagttttt tttatttcta caaaacggat gtggtgatct 2877121 tcggcgtcga ggattttaaa ttcacagccc tccgcgtgta tcacatcccc tgctttcagc 2877181 tccatttttt gcgttagaag ccagcctgca atcgtatcaa tttcttcatt ttcaatcgca 2877241 atgtcgagaa ggtcattcac ttcgtctatt agcgcttttc catccatcac ataatggtgc 2877301 tcgccctttt tcaggatgtg cggtgtttca tcctgatcat actcatcgcg gatttccccg 2877361 acgatttcct cgataatatc ctctacagtg acaagccccg ccgttccccc gtattcatcg 2877421 acaagaatcg ccatgtgaat ccgctccttc tgcatgcgga ttaaaagctg ctgaacagga 2877481 atgctttcaa tgactctgat aacgggcctc atgatttgat tcagctttat cggctggccg 2877541 agaaaataag ctttaaacat atctttgctg ttgatgatcc ctaaaatatg atccttgtca 2877601 tctttgatga cagggtagcg tgtataccgt tcattaatga tgtgatgaat tgcctcttca 2877661 agcgactgct ccagagagat aaccgcaatt tctgtccgcg gaatcataat ctctctcgct 2877721 acccggttgt caaattcaaa aatcttattt acatagcgga attcagactg attgatttct 2877781 cccttttcat agctttcaga aaggatcagc cttagttcct cttcgctgat gacaacctga 2877841 tgctccttta ccgaatgaaa gccaaacaat ttcacaagaa aacttgcaga gccgtttaat 2877901 gctttaataa acgggtacgt gattttataa aaccagatca gcggctttgc aatccataag 2877961 cttacagctt cagctttttg aatagaaacc gttttcgggg caagctcccc catcaccaca 2878021 tgcaaaaaag tgacgatgat aaatgcaact acaaatgtga caatgtggtt aaacggttcc 2878081 ggtatgcctg tcattgtaaa taagggatga agaaaacgtt caaatgtagg ttcaccaagc 2878141 cacccaaggc cgagggctgt aatcgtaatc ccgagctggc aggctgataa atactcgtca 2878201 agattggaga tgattttatg tgcggctagt gctcggctgt caccgctttc gatgagctga 2878261 ttgatttttg aacctctgat tttgacgatc gcaaattccg ctgcaacgaa aacagccgta 2878321 atgccaatca aaacaaaaat ggcgatcaat tgtaaaataa gcaaaaaaag cccttaccat 2878381 aaatggtaag gggccacctc cttaacgtta attctcatca cgaccgttta agaaaatcat 2878441 cacaaaacga agtagttcaa acagggaaac cagggcggcg gccacatacg ttaaggcagc 2878501 agcactcagc actttattta ccccattttc ttcattgttt cggatgaatc cttctgacac 2878561 aataatctgc ttcgcacgtg aacttgcatt gaattcgaca ggcaatgtaa tcagctggaa 2878621 aaagacagcc gctgaaaaca gtatgatgcc aagcccgatc aaattcaggc tgccgagaag 2878681 catgcctcct aagaaaagca aaggagctac accggatgca aaattcacga ctgggaagat 2878741 tttatgtctc agcacaagcg caccatatga ctcctgatgc tgcaaggcat gtccgacttc 2878801 atgggaagct acggatatgg cggaaattga gcggccgtaa tagaccggct cagataaacg 2878861 caccacccgt cttgtcgggt cgtaatggtc tgttaaagtg cctcttaccg gttcgaccgg 2878921 cacgtcgtaa agaccgttta tatctaaaat ccgtcttgcc gtttctgccc ctgtacgtcc 2878981 gcttgaggct tccacttttg aatatttttc aaagttgctc tttactttaa attgtgccca 2879041 aaacgacaat cccaatgcgg ctattgttaa aaatataaac agcatttttt catcatcctt 2879101 tgttcatgat catttctcta ttacgattat tttaatgagt tttctttctc gtgtacagaa 2879161 atgcgctttt tcttccggct tggagcacac aatccaatca gcaaaaagaa caggcctgct 2879221 gaaaacaaat aaaaggcgaa actgccggcc agttctttca gaaaatgaag ccaggagaag 2879281 cttccggaaa agtgattata tgaattcaaa tcgaaaataa acaaaatcac cgcggatgcc 2879341 gccagctgcg taccgattaa aaccacgatc gttctttgaa agatcgtcat ctttttcatc 2879401 ctttttgttt tagtttatgg agaaatccgg ttttatatgt tttgtacatt ttttgaaaaa 2879461 catcaccgga agtgggacat actgttagaa aaaagcacgg gtgtgatgga agctatgaaa 2879521 gtgacgagtg aggaaaagga acagctgagc acagcaatcg accgaatgaa tgaaggactg 2879581 gacgcgttta tccagctgta taatgaatcg gaaattgatg aaccgcttat tcagcttgat 2879641 gatgatacag ccgagttaat gaagcaggcc cgagatatgt acggccagga aaagctaaat 2879701 gagaaattaa atacaattat taaacagatt ttatccatct cagtatctga agaaggagaa 2879761 aaagaatgaa atcaaatcgg atatttattt catggctcag gtggccgtta tttatccgaa 2879821 tcggggttat tattttatgt ctgattcttt tgttcggcca aatcatttat atacttgagc 2879881 ctaagcagtt cacttcggta ttcgaaggta tttggtgggc tgtcgttacg gtttctacag 2879941 tcggttatgg agactatgtg ccgcacactc cgctgggaca ggcagccgga atactgctga 2880001 ttttgagcgg agcaagcttt gtcacagcgt atttcgctac gttatcagcg gccgcattca 2880061 gcagacagca tcgctacatt gaaggaaaag ttgcttacaa aggccgggac cacatcattc 2880121 tgatcgggtg gaatgaaaaa acaaaccggc ttttgaagga ccttcagctt gccgcccctt 2880181 ccaaaacagt cgtactaatc gatgaatcct taacagaagg cccgcttatt gaaaacgttc 2880241 atttcatacg cgggcacgct gccgatgatg ggacactgaa acgggccaat attactgaag 2880301 cggaatcagt gatgattact gccgatcagt ataaaagtga aactgatgct gatatgctgt 2880361 cagtgctgac tcttttatct gttaaaggtc ttaatcccct tgcttactgc atcgtcgaga 2880421 ttttaactga ccgttttgtc accaatgcgg aacgggcagg cgcaaaccaa atcatcggaa 2880481 cttcagaatt tatcagccgg gcgatgctgc agcattacca agtcaagtta cggccgtcta 2880541 aacagcagaa cggaatcaag ctgacacttg atcagcatgt ggagcttctt gctgttcctg 2880601 acgaactaaa gggagcggct tacaaaacct gtgttctcta tttccttgat cacaacacaa 2880661 caattatagg catacaaaaa aaggaggggc cgatgctttc ccctcctctt acatacaagg 2880721 tgctcgaaac agatcaattc cttgccatct agtgtaacag aacatcctcc aattctttca 2880781 cgagagaggc gccgatatcc aaaaatgccg gatcaatttc cgcgtcccgc ctttccggtt 2880841 cggaaaattg attaaacagt gattggaaag gccctccctc ggcgtgatcg tcaacatccg 2880901 cctgaaacac ctgtctcagc ataaatggcg ttccgatccg gacggccgcc cctcgttcat 2880961 cgagactgcc ctgtaccgca ttgacgggaa ttcttaaaaa taaatagccg tctctatcat 2881021 caattttata atcaaagtag ccatgatcgt attcccagcc gccgtttatc acataaccga 2881081 gcggcttcat cacttgttcc agttcttgaa gcagaaaaga ctgcccatct atcgcggaag 2881141 gtattggtat catcagaatg cccctttttt cacttatcct gtcccgccga acaagacttc 2881201 attcagaggc gcctacatgg aaatcgttgt ttctttcgcg cggccaacag gaaagaaagc 2881261 gcattcaatt aagaagtaaa cagccattgc cgctgcaagc catacagctg aatcccaaga 2881321 cacataaaca accgttgcat agagtcctaa tttagtgaaa agagtatggg ttcgttttaa 2881381 atgcaaaatc cgatgtaccg catcggtaaa aagggcaagc ggcaaaccaa tgagaagaaa 2881441 ggagtggatg aaaaaatgtg acagcgtgcc gccaaagctt gaagaaaacc ctgtatacac 2881501 ggcatcaaag gagataagga aacttaaaat agctgcagaa aaaccggcaa tgatgagatg 2881561 tttaaccaat tgtttcatga acatcagcac ctttctgatt ttataaaaag ccgaccggca 2881621 aatgccagtc agctttctca cattaatctt ccagacgttt ttcaagctct gcttttttct 2881681 cttcaaagcc aggtttgccg agtaacgcaa acatattgac tttatacgct tctacaccag 2881741 gctggtcaaa cggattgacg ccaaggaggt aaccgctcat cgcgcaggct ttttcgaaga 2881801 aatatacaag gtatccaaaa gtatatgcat tcagctcagg aatgttaacg attaagttcg 2881861 gaacatttcc gtctgtatgg gcaagcattg taccttggaa tgcttttttg ttaacgaaat 2881921 caacagtttt accggctaaa tagttcaagc cgtcaagatc gttatccgct tcctcaattg 2881981 tcagttcatg tttaggcttc tctacgttca ggaccgtttc gaataaatct ctgcggcctt 2882041 cttgtacata ctggcctaaa gaatgaaggt ctgttgaata gttcgctgaa gaaggataaa 2882101 tgcccttctc atctttccct tcgctttctc cgaacagctg cttccaccat tccgcaaagt 2882161 attgaagcgc cggttcgtag ttgatgagca tttcaattgt tttgccctta ttataaagga 2882221 cattgcgaac aaccgcatat tggtatgctg ggttatcttc cagttcagat gttgcaaaat 2882281 ctttgctcgc atccagggcg cctttcatca tgtcgtcaat gttgacgccg ctgacagcaa 2882341 tcggcaagag acctacagct gttaaaactg aataacggcc gccgacatcg tcaggaatta 2882401 cgaatgattc aaagccttct tcgttagaaa gcgtttttaa tgcgccgcgc tctttatcag 2882461 ttgttgcata aatccgcgct ttcgcttctt ctttaccgta tttctcttca agaagcttgc 2882521 ggaaaatacg gaaagcgatt gcaggttcag ttgtcgtacc tgatttagaa atcacattaa 2882581 tagagaagtc aacatcttca agaagatcca tgacgtctct catataagat gaactgatgt 2882641 tgttcccgat aaaaatgact tgcggattgc cgcgttttgc ttttggcaaa gtgttataaa 2882701 acgcgtgatt cagcgcttca atcgctgccc gcgctccaag ataagaaccg ccgatgccga 2882761 caacaagcaa gacatcagag tcagatttga ttttttccgc gctttttttg atgcgcgcga 2882821 attcttcttt atcataatgt tcagggaggt ccacccagcc tagaaaatcg ctgcccgcgc 2882881 ctgttttctc atggatatta tggtgtgctg tttttacaaa gtcccgcagg tatgtaagtt 2882941 catgttcgtt gaagaaagtc aacgcttttg agtagtcaaa gcgtacatgc gtcattgctt 2883001 gtccctccat aacggtataa tgttttcatc tttcacttta tatgaactta tctgtgaaat 2883061 caagtcaaga agaaagggcg gaatgactgg attccgccct ttgggtttat agagacgcgc 2883121 gaaggatggc aagcacgtca tctttgttca gtttttggaa gttgccgaag ccgccgtgtt 2883181 ccatttcctt ggctgcgata tcagcaatca gctcaagctt ttcttctcca atattgtaat 2883241 cagcaagacg agaaggtgca ccgaggcttg tccagaacgc agacagttta tcgattcctt 2883301 caagcgcaat ttctttatct gttttgcctt cagtatcaat gtcaaacatg ttgagcataa 2883361 ggtttttaaa acggcctaca tttgtatcaa gcgtgtatct catccaattt gggaacagta 2883421 ttgccaaacc gcccgcgtgc ggaatatcat atacagctga aacagcgtgt tccattgtat 2883481 gagaagccca gtcaccgaag tatcccattt ggagcgtgcc gtttaaagca atagtaccag 2883541 catacaaaat cgtttcacga agttcgtagt tttccagatc ttcaagaagc ttaggagctg 2883601 tttcgatgac cgtctgcaaa acagcaaagc acattctatc ctgaagcggc gtgttttcaa 2883661 cattatggaa gtattgttcg aatacgtggc tcatcatgtc aaccatgccg tatactgttt 2883721 gattttctgg aacggtgaac gtattttcag ggtctaaaat agagaaacgc ggatgagtga 2883781 cattgctgcc ccatacaaat ttctcgtttg tttcccagtt tgtaatcacg gaatcagggt 2883841 tcatttcaga ccctgttgca gcaagagtta aaacagtgcc aaacggcagc gcatcctccg 2883901 ctgttacttt tttgctgaaa atatcccaag cgtcaccgtc atatttgacg ccagctgcga 2883961 ttgcctttgt acagtcaatc acactgcctc cgccgacagc aagcagaaaa tcaatgtcat 2884021 gctctctgca aagtcctatg cctttttcca ctgtcgcaag acgcgggttt ggctctacac 2884081 ctgacagctc atgaacaaca gcgccctctt cttttaaaat gcctgtgact tgatcataaa 2884141 ggccgttgcg tttaatgctg ccgcccccgt aaacaagcag tacattcttg ccgtatcgtt 2884201 tgaattcttt tcttaattgt tcaagctgac cttttccaaa aatcagcttt gtcggattat 2884261 aataagtgaa attttccata gtaaaacctc caaatgatgc tggtaaaaaa cagattttcc 2884321 attgtaacat aagttgacaa aaaagaaaaa gggaagcagc caaacggcta tttccccttt 2884381 ttttatagtg atgctttcaa aattgacagc acatcttctt tgttgagtga tttaaattgg 2884441 ccgaatgtac cgttagccat tgccttgtca gcgattgtgt caagctgctc atcattaata 2884501 tcataatcag caagacggtt cggagcgcca agacttgtcc agaatgcgga cagcttatcg 2884561 ataccttcaa gggcaatttc ttcatccgtt ttacctgctt cttcaacatc aaacacgcga 2884621 actgcaagct gtttcatgcg ggcagggttt tcagacaatg tgtgtctcat ccaattcggg 2884681 aacagaatcg ccagtccgcc ggcatgcgga atatcataaa cggctgatac tgcatgttca 2884741 atattatgag tagcccaatc ccctcttgcc cccatagaaa gcatgccgtt taatgcgatt 2884801 gttcctgtgt acaggatcgt ctcacgcaat tcgtaatttt cgagatcatt gatcagctta 2884861 ggcgctgttt caatgactgt acgcaaaagt gattcacaca tgcggtcctg atacggcgtg 2884921 tttgatacat gatggaagta ttgttcgaat acgtggctca tcatgtcaac catcccgtag 2884981 atcgtgtggt ttttaggtac ggtgaatgta ttcaccggat caagaatcga gaatttaggg 2885041 aatacgagcg ggctgcccca gccgtatttt tcttttgttt cccagtttgt aataacagat 2885101 cctgagttca tttctgaacc agttgcagcg agagtcaata ccgttccgaa tggcaaagca 2885161 tcttttggct gatgcttttt cgtaacgata tcccacgcat caccatcata cttcgctcct 2885221 gcggcaatcg cttttgtaca gtcgattacg cttccgcctc cgacagccag caagaaatca 2885281 atgttttgtt ctttacagat ggcaacacct ttattaacag tcgacacacg aggattcggt 2885341 tccacacctg ctaattcatg cacggtcgct ccggctttat tcagctgttc aatcacttga 2885401 tcatacaggc cgctgcgttt aatgctgccg cctccgtaca caagcaatac gttttttccg 2885461 taaggtttga gttcctccgg aagtctttcc acttcgccgc gcccgaaaat taatttggtc 2885521 ggattccagt atgtaaagtt ttgcatgaca tctcctcctt agatttttta ttatgcagaa 2885581 tgtcctcacc acatgtaaag caatcagctc tcaccgatca gcataccaga tggttttatt 2885641 ttgcaaggtg ctgggaaaga agctgatata agcgagggca ggccagcttc cctcatatgg 2885701 agaatgcatg tatagattct ccaatatgtc acaatctata actgttttaa taattcatgg 2885761 aggaggttgc aaaacatgag taccattcaa agaatttgtc ttgtattaac catcattggc 2885821 gccattaact ggggactgat cggatttttc caatttgact tagtagcggc tatcttcggc 2885881 ggccaagggt cagctctttc ccgaatcatt tacggacttg tcggaatcgc cggcttaatc 2885941 aacctcggtc tgctatttaa gccaaacgag gaaagatcac gtgaagaagc agcaaatcct 2886001 gaaatgcgat aggatatcaa tcacgctgaa ataggatttt gcatgaaatc aaaagcaccg 2886061 aacattcctg tccggtgctt ttttcatgct tattttttga taaggtcttt gcggttggac 2886121 atttcgatcc actcttcaag cttatctttt aatgtgttga aaccttgtgg tgtagaagct 2886181 tcttcgctta cttgagcagc tttaggtttt cttggtttgc tttctttttt ctcaggcgca 2886241 gcttgtgtcg cacgaattga aaggctgatt ttgccttttt cttcatcaac agcaagtact 2886301 tttacttgta cttcgtcgcc aactgaaagg tgctcgttga tatcttttac gaaaccgtga 2886361 gtcacttcag aaatgtgtac taaaccttga gtttcttcat ctaatgcaac aaacgcacca 2886421 tacgcttgta atcctgtaac tttaccagtg taaacactgc ccacttcaaa ttttgctgcc 2886481 attcataaca actcctaagt taaattaaat atctgtttat acgcaattta aaattatatc 2886541 acacatgtct tatttccgca aagaaaactt ttttataaaa aatcaggttt atgcacagca 2886601 aaaagggggt aaactgaaaa taccaaaggc tttctagtat tccccccttt tattggatgc 2886661 gaacaaaagg ttcgtatctt tttttatgtt gttttgtgca ggaagcgttt cattctgact 2886721 aacgcttctt gaagctgttc aatcgaggtt gcgtatgaac aacggatata tccctcaccg 2886781 ctcggaccaa acacacttcc aggaacaact gccacttttt cctgcgtcag tagctcctcg 2886841 gcaaactgtt ctgaactcat tcccatgctt ttgatagatg gaaaagcata gaaagcgccg 2886901 cccggatgat gacagctgag accgatttca ttgagcgatt ctacaaacag attccgtctt 2886961 cttcgatagc tttttttcat tttttctacg tcttccatgc cgttcttcag gccttcaagg 2887021 gcggcaaact gcgccattgc gggcgcgcac atcatcgcat actgatgaat tttaagcatg 2887081 gcatcccgaa gcaaggatgg tgccgcggca aaaccgagcc tccagcccgt cattgcaaat 2887141 gcttttgaaa agcctgagat gactaccgtc cgttccttca ttcccggtaa tgccgctata 2887201 cttgtaaatt cctcatcata tgtcagctcc gcgtagatct cgtcggctaa gacgatgaca 2887261 tcatgttttt tggcaaactc agcaatctca ttcagctctt ccttcgaata aaccgaacct 2887321 gtcggattcg atggtgagca gatgagaatg gcctttgttt tttcagtgac tgccgcttca 2887381 aaatcagcag ccgttgcttt aaatcctttg tctgccgttg tatgaacgtg aaccgggata 2887441 ccgcctgcca aagaaacaag cgcatcgtac gcaacaaaac acggctcagg aatgatgact 2887501 tcctcacctg gattcacaat ggcgcggatc gcaatatcca aagcctgact tgcccccact 2887561 gtcacaatca gctcattatc tggcgagtag ctaaggtcaa acctgttgct caaataacgg 2887621 ctgatttcct cccgcaatga gtataaaccc gcattggccg tgtatgacgt atatccttgt 2887681 tcaagagaga gaatgcttgc ttcgcggaca ttccatgcgg taacaaaatc aggctcgccg 2887741 acgcctaaag aaatgacgcc ttccatcgtt gccgccaaat caaagaattt gcggatgccg 2887801 gatggtttta tttgttgtac atagtctgat aaatacgaag tcatttacgg tgacaccacg 2887861 attcttttgt cgtcgtctcc tgtttcaaac actttgccgt catgcttgta ttttttcagg 2887921 ataaaatggg ttgtcgtaga tacaactgaa tcaagcgttg agagtttatc cgaaacaaaa 2887981 cgcgctacgt cagacatcga attgccgcga atcacgacag acaaatcgta tacgcctgac 2888041 atcaggtaaa ctgattcaac ctcttggaat cggtaaatcc gttccgccac ttcatcaaaa 2888101 ccgacgcccc gcttcggcgt tactttgacg tcaatcatgg ccgtaacgcc ctcatgtccg 2888161 tcgacttttc gccagtcaat catagcggaa taatcgataa taaccttttc tttctccagt 2888221 ttgtcaataa ttgttttcac ttcatttaca gggatgcccg ccatctttgc gattgtttct 2888281 aaatcggcgc ggctgttttc gtctaaaatt tctaatattt ctgtttcttt ttctgtcaat 2888341 ttcatttgat tcacaccttt gcaatgtcaa gaaatctcat gacattatat cacgtttttt 2888401 gacgaatgct aagaaaaaac gaggagaaac ttccgctaga attgacaatt tcagggcata 2888461 atacaaccat caaaaaaagg gagtgacaca gaatggaggc ggtttcacca ataaggcggt 2888521 ttacggtcga tggagtcaat gtatactacg aacattatca aaatcccggc aggcaaacgc 2888581 tggtctgcgt acacggtttt ttatcatctg cattcagctt cagaaaagta attcctctcc 2888641 ttcgggacaa gtacgacatc atcgcgcttg atttgcctcc tttcggccaa tctgaaaaat 2888701 caagaacgtt tatctatacc tatcaaaacc ttgctaagct tgtcattggg attttggagc 2888761 acttgcaagt gaaacaggct gtgcttgtcg ggcattctat gggcgggcag atatcgctgt 2888821 ctgctgctct ccaaaaacct gagctttttt caaaggttgt gctgctttgc agttcagggt 2888881 atttaaaacg ttcacacccg acgattattt tcgggaccca tatcccgtat tttcatcttt 2888941 acatcaaacg ctggctctcg aaagaaggcg tgatgaaaaa tttattaaat gtggtgcatg 2889001 acaaatcgct gattgatgag gagatgattg acggctatgg cagaccgttt caggacgagc 2889061 agattttcaa agccatgaca aggtttatcc gccacagaga aggagattta gaacccgagc 2889121 aattgaagaa aatgaacaag cctgctctat tgatttgggg cgaggaggat cgaattgtcc 2889181 caatggagat cggtaaacgg ctgcacgcag atttgcctaa ttccgtgctg tactcacttg 2889241 gccagaccgg acatctggtg cctgaagaac ggcctgaact tatttctgaa cacattgctg 2889301 attttatcaa ataacaaaaa aaccggtgct gaaccggttt ttttaaggcg tgcaggagct 2889361 gctgttttta atgaataaaa gctggccagc cacttcccgg cagctggcga tcggcagcgt 2889421 ttgttcaaaa gaagtttcaa atatttgctg aatgcttttc gccagcaagt cgggatcgtt 2889481 ttcatcatag actgcctgca cgacatcaac agcctccgtt tcgtaaaact cttctccata 2889541 tttaaacggg tcccatttgg caatgatctt aatcatttcc ctgaccgcat gactttcttc 2889601 catattcatc accgcttata ataaaatttg cagttctatc ttatcatagt gaagcttaga 2889661 agaataaaca tacatgaggg ggtaacagaa tgaactttga taaacgagaa gaacgccttg 2889721 gcacccaatc ggtcaaatgg gataaaacag gcgaattatt tggcgtgaca gacgccctcc 2889781 cgatgtgggt ggcagatatg gattttcgcg ccccggaagc gataactgaa gcgttaaaag 2889841 agcgtcttga ccacggtatt tttggttata caactccaga tcaaaaaacg aaggatgctg 2889901 tgtgcggatg gatgcaaaac aggcacggct ggaaggtaaa tccggaaagc atcacattca 2889961 gccccggcgt tgtaacagct ttgagcatgg cggtacaagc ttttacggag ccgggcgatc 2890021 aagtagttgt tcagcctcca gtttatacgc ctttttacca tatggtggag aaaaacggcc 2890081 ggcacatttt acataatccg ctgctagaaa aagacggcgc atatgcaatc gattttgaag 2890141 atttggagac aaagcttagt gacccaagcg ttacattgtt tattttatgc aatcctcata 2890201 acccttctgg gcgttcatgg agccgggaag atttactgaa gctaggcgaa ttgtgccttg 2890261 agcatggcgt cacagttgta tcggatgaaa tccattccga tttaatgctg tacggacata 2890321 aacacacgcc gttcgcttcg ctctctgacg atttcgctga tatttccgtg acatgtgctg 2890381 ctccaagcaa aacatttaat atcgccggat tgcaggcttc agcgatcatt attccggatc 2890441 gcctgaagcg cgccaagttt tccgcaagcc ttcagcgaaa tggtttaggc ggactgaacg 2890501 cgtttgccgt cactgcaatc gaagccgcgt attcaaaagg cggaccgtgg cttgatgaat 2890561 tgatcactta cattgagaaa aacatgaacg aagcggaagc ctttttgagc accgagctgc 2890621 caaaggtcaa aatgatgaag ccggatgcat catacttgat ttggctcgac ttcagcgctt 2890681 acggcttgtc cgatgcagag cttcagcaaa gaatgctaaa aaaaggaaaa gttattttag 2890741 agcccgggac gaaatacggg cctggcggag aaggatttat gcgcctgaac gccggatgct 2890801 ctcttgcaac cctgcaggac ggcctgcgcc gcatcaaagc cgcattatcg taaatatagc 2890861 tgtaaacgcc tttacgtctt catttgtaaa ggcgttctta ataaaggaat tttatatttt 2890921 acttctaata tttagtgtta taatagattc atattttata cgaaaggatt tcacacgaat 2890981 ggaaattcta aaagactatc ttctgcacat ctgctttatt ttgtttccta ttcttcttta 2891041 ccaagtgttt tggcttggaa aacctgcgat tcttgtgcca aaaataaaca gcggtttggt 2891101 cacgctcttc gcctgcggcg cctccgtttt atgcattatt ttcccgattc atgaaatgga 2891161 ctacatacaa tacggccttc agatgattcc cgttatcatt tgtttatttt acattagtac 2891221 cgcttccgga cttacagtcg ccgcatctgt cctatgtttt gaactgcttt tttacgaacc 2891281 ttccgcaatg tttgttttca ctttgctgcc ttttcttatc attatcccaa tcttatttca 2891341 gaaaaaatgg ccattcatgt ccaaagcgaa aaaactgctg ctgtctttat tgatcagctg 2891401 cgtggagatt ttcctatttt tcgcctcaag ctggattctt tccgccttga atattttaaa 2891461 ttttcaaaaa tcaggaattt tcgtttacga ggcggcagtc tcagggcttt tccgctccag 2891521 tgttcttcta ttaagcatct atattatcga aagcatcgcc gaaaatatcg ccctgcgttc 2891581 acagcttatc cattctgaaa aaatgacgat tgtgagtgaa ctggcagcga gcgtcgccca 2891641 tgaggtcagg aatccgctga cagttgtccg cgggtttgtc cagctgcttt ttaatgacga 2891701 aaccctacaa aacaagtcga gtgcggatta caaaaagctt gtactgtcag agcttgaccg 2891761 ggcgcaaggc attatcacaa actatctcga tatggccaaa cagcaattat acgaaaaaga 2891821 ggtttttgac ctatctgccc ttatcaaaga gacaagctcc cttatggtgt cgtacgccaa 2891881 ttacaagtca gtaaccgtcg aggctgaaac agaaccggac cttttgatat acggagacgc 2891941 aacaaagctg aagcaggctg tcatcaacct gatgaaaaac agtattgaag cggttcctca 2892001 cgggaagggg atgatccaca tatcagccaa aagaaacggc catacgatca tgattaacat 2892061 cacagacaat ggggtcggga tgacagacca tcaaatgcaa aaactcggcg aaccttatta 2892121 ttccttaaaa acgaacggaa cgggactcgg cctcaccgta accttttcca ttattgaaca 2892181 tcatcacggg accatttcat ttaacagcag cttccaaaaa ggcactacgg tgaccattaa 2892241 gcttcccgct gatcttcctc actagcaaat cgattggaac tttaatagaa taaatgcgag 2892301 gtgatgacag atgagcacgt ttgagacagg ctctatcgtt aaaggatttt acaaaacagg 2892361 tgtatacata ggagaaatca cggcttgcag gccgcagcat tatttagtga aagtgaaagc 2892421 ggttcttacc catcccgctc agggagacct tcatcatcca aaacaggcgg atgtgccatt 2892481 ttttcatgag agaaaagcgc tcgcatatgg tgaacagacc aatatccccc accatatggt 2892541 gaagccttat gacggtgaag tgccggatta taccgaatct ctgcgggagg cgacagcaca 2892601 gatgagagcc aaattgaatg aggatggttc ggagtgggca aagcgctccc ttcataatct 2892661 ggacatttta gaaaaagaat attttaaccg gccataaccc agtctgacaa aagattgggt 2892721 tttttacgtc gcgcgcttca acagttcggt taaatcgatt ctctcgccga ttgtgggcgg 2892781 ttttggcttt tcgagatact gcttatcctg ctcaacaagc ttaaaaagtt tatatgctgt 2892841 gagagcatca tcaagcgctt tatgatgggt gccggttccg gaatctccat actcttcggc 2892901 agctttccat aaacccgtca atgtccggtc tccaaaaaag tttttgtatt caagcgataa 2892961 atctctcatt tctcccttaa acgggaaagg gatatggtta aacatacagt tttgcttcag 2893021 cactttcata tccatgtttc cccacgtaat aattgtgctg tttttctcag gatccagctc 2893081 gtttagttta cggatgaaat cctcgaatct cattccttcg tctacctgtt tttgggttat 2893141 ttttaaaaat gatttgcagc gtttcgtaag cttcgggaac tttttcggtc taacatagct 2893201 agaaaacgtc tcaaccactt catcatcaat cgactttaca attccggctt caatgatttc 2893261 cgggaagaag ttttgaggac tgtactttcc atcaggcatt gtaaattcga aatcaataat 2893321 gagtaagctg tttgtcgtca ccttttacac ctgcctttcc tccgatcaga aaatgctatc 2893381 tttatagtat atcaattccc cttctcgaca tttcttcatt ttctaaaaat aatgaatttt 2893441 cccagccgct tcgtttcttt taaattgtga atcgtttctt tataattagt aaggaacccg 2893501 aaataataag aaggtgatgt tatttctatc cgtaagaaaa actttgtcat tgtgtggctg 2893561 gcgaactttt ttgtctccgc tagcacaacg atgatcgttc cttttctctc cttatacatt 2893621 gagacgctca gctctttttc aaacggcttt gtgcaaaggt ggagcggcta tgtgttcggc 2893681 attacatttc tcatggcgtt tttggtatcc ccgttttggg gacggttcgg agacaaacgc 2893741 ggatacaaga aaatccttat ggcaaccgga acaggcattg ccctcagcat tttcttcatg 2893801 ggctttgtta catcggtgta ccaattgttt tttctgcgta tggcaatggg tcttgtaacc 2893861 ggattcatcc cgacatctct tgcgatgatt tcggcacaga ctccgaagag ctcagctggc 2893921 aaaacactcg gcacgctgca aatggggcaa gtgtccggaa gcttgttcgg cccgcttttg 2893981 ggaggcatgc ttgctgatcg tttcggcttt acgtatacct tttttatcac atcctttgtg 2894041 attttctcgt ctgttcttct cgtgttattt ggtgtcaaag aaaagcatct tgcagagaaa 2894101 acagccaaac gtacgtctta ctcgagaaaa gaagtgctct cctatatttt tcaccatccg 2894161 gcgctgtggg tcatgatgct gttaaccatg ctgattcaaa caggcaattt cagtatccag 2894221 cccctgctcg ctttatatgt aaatgagctg cacggacctg tcaatcttgc ctttttctcc 2894281 ggcatggcat tttcagcaac ggggctcgga agtttgctgc tggctagaaa atggggtgat 2894341 ctgggcgacc gctacggcca ccgccgcatt ttaatcggac ttttgctcgc cgcctctttc 2894401 ttttttattc cgcaggcgct cgcgtcctca ctcagcgtgc tccttgtttt cagattttta 2894461 ttcggaatgg cgatgggcgg tttgctgcca tgcattacgg cagcgatccg cgttcaggct 2894521 cccggcagca ttcaaggtga agttctcggc tacaatgtca gctttcgctt tttaggaaac 2894581 gtgctcgggc ctctgctcgg cggaatcata tcgagccatt ttaccatttc ggccaccttt 2894641 tacgtcacgg cgtttctctt tttcgccggc gcctgcatgc tttggatcat gcagaaactt 2894701 cggaaagatt cttatgccaa agcaagctga ttccgagaaa aaactaagga atcttctaaa 2894761 tttaaccttc tcgtaatctc aaaagaatgg tacgatatgg ctagaattta ggagaaaaga 2894821 gagtgaccat gttacgaaaa ataatcggat ggattttgct cctttgcata atcccattgt 2894881 ttgcatttac agttatcgct tccggaaaag aagtaaaaca aatgaagtcc ctggatcagg 2894941 tgcttgataa aaatattgat ctgaaagata tcagccttgt tcagaacagc tacatgtatg 2895001 acagggacgg ctcccttgtc tcggaaatcg tcagcgacca cgaaaaccgt gtgctcgttc 2895061 catttaacaa gattcccgag gaagtcaaac agattttctt aacatctgag gaccgccatt 2895121 tttacgagca taaaggcttt gactttatgg gaatggtgcg ggctactgct tctaacgtaa 2895181 aagacaagaa aattgaccag ggtgccagca ccatcacaca gcagctttca agaaacttgt 2895241 atttgagcca cgaacgctcc ttcagccgca agctgacaga gctcgcgtat tcctatcagc 2895301 tggagaaaaa atatacgaaa aatgaaattc ttgaagctta cttaaatacc atttatttca 2895361 acaacggtgt ttacggcgtc ggttcagcag ctcaattcta tttcagcaaa ccgctgaaat 2895421 ctctcacagt gggagaaatg gcttttatct gtgctatacc taataaccct acattatatg 2895481 atcctctcaa gcattttgac tacacgaaaa gccgtcaaga acgtttactt aaagggctaa 2895541 aagatgccgg ggtcattacg gacaaagagc tgaaaaaagc cgtaaaacaa aaaatcaaac 2895601 tggatgttga aaaaagagaa gacaaatatc ctgactacgt ttcctacgtc aatgatgaat 2895661 tcactcagct ggtgtctgaa tcagaaggct ttgataaacg ccttcaaaaa gcatcaggaa 2895721 aacaaaaaga aaagatcgag aacgagctgt ccgcaagagt cagcacgctg atgaaagacg 2895781 gagtgaaaat ttatactgca cttgatccgt acatgcaaaa tcaagttgtg gcacaaatga 2895841 attccaagct cccgtatgcg gacgtacagg gcggagcggc tgtgattaat caccagacgc 2895901 atcaaatcat tgctctatcc ggcgggaaaa actatcaaaa atatgacttt aaccgcgcct 2895961 accaggcgta caggcagccg ggttcatcca ttaagccgct tcttgattac ggcccttata 2896021 ttgaacagac cggcgcgaca acaagcagca ccattgatgc cagcaagttt tgcagcaaag 2896081 actactgtcc gcaaaactac aataaccgca cttacggcac agtgacgctt gatacggcgt 2896141 ttaaaaattc atataatacc ccggctatta gaatgctcga ccgcgtcggc atccaaaagg 2896201 cattcagtta tattgagccg tatcattttg ccaaacttgt cgacagtgac tatcttcttc 2896261 cggcggcgct tggcggattt acaaacggca tgacgcctct tgagatgaca aaggcttata 2896321 cgacattcgg aaacagcgga agctatacgc cgagccatgc gattacaaag gtgacagacc 2896381 ttaaaggaaa aacactttat aaatggaatg ataaagcgac tcaaatattc agcgtccgca 2896441 cgaacatgca gctgaaaaaa ctgatgtctt ccgttgtgaa aagcggaaca gggaaaaaag 2896501 catatttcaa tgcgccttac atcggcggta aaaccggaac atcaaatgat tatcacgata 2896561 tgtggtttgt cggcctgact gatacgtata caatgggtgt ctgggtcgga aaggatacac 2896621 cgaccagcgt tgaatatctt cacagcatca gccctcagct ttccatctgg aaaggaacgc 2896681 tgcaagcggc ttattaaagg atcggagggg atatggagtg acttcagaac aaattccaaa 2896741 tcgcgttttg ctgtttgacg gtgtctgcaa tttatgcaat ggcgccgtgc agtttatcat 2896801 taaacgtgat ccggacggat tgatttcttt cacatcgctg cagtcggaaa caggacagag 2896861 cctgctgaaa aaaagcgggc ttccgactga tcggtttgac agctttgtct ttattgaaga 2896921 cggccaagtg tacacaaagt caactgcagc cattaaggtt ttcaggcatc tgcgaggccc 2896981 atggcggctc ttcgtccttt ttttcgcagt gccgaagcct gtcagagata tggtctattc 2897041 tttcattgcc aaaaaccgct ataagtggtt tggcaaaaaa aatgaatgta tgctcccctc 2897101 cccttccatt aaaaaaagat ttttaccgta aataaaaaat ggctaggaag ctagccatca 2897161 cagattgttg acaaaatcct aaaacggctt cgttttagga ttttgtcatc tattcagcgt 2897221 gattgaaaac ttttgaagtt gtgaaacggc ggaaacctga gaatctagcc gccgtttcat 2897281 tgcgtacaga gcacgaagcg caaatctgac caccaaacgc tgaaatggct agcttacaca 2897341 ggtaagctag ccattatgct attataaagc ttgataaata tgaacagaat accgataaca 2897401 aaggtaaacc aaaacagcag ttccaataga atgaatccaa ctaatgacat gagagaaagc 2897461 gtcgaataaa tccggtatac ggtaaacaca aagtaagcga gcgtgacgac cgcaaaccag 2897521 atcacaatcc aaatgacatt ttgcaagagc acaaaggata aaatcccgcc gcccaaataa 2897581 atcatggaac ccattctgag ttttttcagg ttgttccctt ccggatcatt agcaaaaaac 2897641 agcaatgaca gctcggtcac ggtatttgca attaatttca gagcggacag aaccataaaa 2897701 tataaaagtg caaaggcagc aaataacgca agcctgattc ctttctctga aaaataatcg 2897761 agcattccat catacattcc aaatgaagac agcatcttca acgcataaag tgaagttgag 2897821 atggataagg acgaactaaa aagcaggatc gcaatcagcg gaaaatatcc tgtcaaataa 2897881 gtatttttca tataaaaaag tccctttcta taatctacct catttattat ggaggactta 2897941 aaacacattg acaagataaa ttattccatt ttttctcctt tttacgaatt acgggcccaa 2898001 atcttcacaa agcagcattt tgagagtaaa gtagtacgca ggaatcataa aacgtaagga 2898061 agttttatat gaaaaaaaca ttaaaactgc aaaccagact caccatattt gtttgtatcg 2898121 ttgtattaat cgcattgctc attacgtttt ttacagtcgg tgcccaaacc accaaacgaa 2898181 ttagagatca ggaaaaggcc actgcgctgc agactgctga aatggtagct gaagcgccga 2898241 tgacagccgc tgctttagaa agcggaaaaa aacaaaagga actgcagagc tacacaaagc 2898301 gggttcagaa aattaccggc acggaatttg ttgtcgtcat ggatatgaac ggtatccgca 2898361 aaactcatcc tgacccgagc aaaatcggaa aaaaattcag aggcggtgat gagtccgagg 2898421 tattaaaagg gcatgtccat atcagcacag cctctggcac gctcgggaaa tcgcagagag 2898481 cgttcgtccc tgtctacgcg gagaatggaa aacaggtcgg tgcagtcgcg gtcggcatca 2898541 ccgtaaatga aattgatgaa gtgatcagcc atagcttacg gccgctttac tttattattt 2898601 gcgtcagcat cttcgtcggt gtgatcggag ccgttatcgt cgcccgtaca gtgaaaaata 2898661 tcatgtacgg acttgaacct tatgaaattg cgactctgct tgaagaacgg agcgcgatgc 2898721 tggaatcgac gaaggaagga atactcgctg tcgatgaaca tggcaaaatt aaacttgcca 2898781 acgcggaagc aaaacgccta ttcgtcaaaa tgggcatcaa cacaaatccc attgatcagg 2898841 atgtagatga catcttgccg aaaagccgct tgaaaaaggt cattgagaca aaaaaacctc 2898901 ttcaagacag agacgtccgc attaacgggc tggagcttgt gtttaatgaa gttcctatcc 2898961 agctgaaagg acaaactgtc ggagcgattg caacattccg cgacaagacc gaggtaaaac 2899021 atttagctga acagctttcc ggtgttaaaa tgtatgcaaa cgcactgaga gcgcagtctc 2899081 atgaatttat gaacaaactg catgtgatat taggtctcgt ccagctgaaa gagtatgatg 2899141 atcttggaga ttatattaaa gatatagcca tacagcaaaa atcagaaaca agtgaaatta 2899201 taaatgatgt caaaagctcc gtactggccg gttttctgct tggaaagcaa agctttatac 2899261 gtgagcaggg cgcaaatctt gatattgaat gcaacggtgt catcccgaac gcggcagacc 2899321 cttctgtcat ccatgaactt attacaatca tcggaaatct catcaacaat ggcttagatg 2899381 ccgttgccga tatgccgaaa aaacaaatca ccatgtccat gcgcttccat aacagcatac 2899441 ttgatattga aattaccgat actggagcag gcatgtctga agaagaccaa gccaaagtat 2899501 ttgaacaagg ctattcaaca aagggcaaaa accggggatt cggcctttat ttcacacagc 2899561 aaagcatcga aaatttaaaa ggccaaatga tcctcacaag cgaaaagaat gaaggaacga 2899621 cattcagtat tcgcatcccg tacgaaccga aggaggaaaa tcatgattaa tgtactaata 2899681 gttgaagatg accccatggt gggtgaatta aataaacgat acttaagcca aatagatggc 2899741 tttcagctga aaggcatcgc ttcttccttt caaagcgctc tgcatatttt aggggagcac 2899801 catattgacc tcattttgct tgatatttat atgccgggaa aaaacgggct ggaactgctg 2899861 acggaattga gagcccaaaa tgaagcggtt gacgtgattg tcatctcagc ggccagcgag 2899921 cttgacgtga tcaagaaaac acttcggtac ggagctgttg attatttaat caaaccgttt 2899981 gaatttgaac gattccaaac ggctctgtct gattacagac gaaaacaaaa ggtgtattca 2900041 acccatcgca acatgagcca aaaagaactg gacgccgagc tttttcaaaa gaaagaagca 2900101 acagaaaaag tgcagcttcc taaaggcctg acaaaaagca cgctgaagct gatctggtcc 2900161 agtatccagt catttgaaaa tgaatctttt acgacagaag acttggcaaa gcacacagaa 2900221 atctctcaag tatccatacg aaaatactta aagtttcttg aagatataca ggttctgaat 2900281 gtagaaatgg cgtacggaac gatcggaaga cctgtgtttc agtacaacgt caacaacagt 2900341 aacattaacg gaataaagca atatctataa gaaaacgcac tgcttgcttt gagcagtgcg 2900401 tttttctgtc atatctcttg ccaagatgct tgattctatt gttgataagt tatacaagaa 2900461 taacaaaggg ctttcacatt tttaagcaaa taattctaaa aatagataat ttttaaaaaa 2900521 ttatgcgaaa ttctatttat ttcttattag ttaaatgata aattatgatt ggttagttga 2900581 tcccgaaaaa ctaagtcata agtcttactt cagaaaacga tgtcacggtt ttccgcccgg 2900641 aacgccttcc gcatccttct cttccccgcc tttcgaagga aatactcaca ccacgcttat 2900701 tcagggaaga atagaactgt ctcagcgcat tccatttgtt attatcagaa aattttatcg 2900761 attctaagaa attgttcagg acagcccatc acatgactgg ccggatcagc tttgaaccaa 2900821 atttttctgg ggggttatat cttgaataaa cgaaaaatcg gattggcgat gtcacttgtg 2900881 atcgcagcag gcaccatatt aggagcatgc ggaaacagcg aaaaaagcag cggctcaggc 2900941 gaaggcaaaa acaaattcag tgtggcgatg gttactgacg taggcggagt ggatgacaaa 2901001 tccttcaacc aatcagcctg ggaaggcatc caagcctttg ggaaagagaa tgggctgaaa 2901061 aaaggcaaaa acggttacga ctatcttcaa tccaaatctg atgcagacta tacaacgaac 2901121 ttaaataaat tggcgcgtga gaattttgac ttaatttacg gcgtcggcta cttaatggag 2901181 gattcaatca gcgaaattgc tgaccagcgt aaaaatacaa actttgcgat tatagatgct 2901241 gttgtcgata aagacaacgt cgcaagtatt acgtttaaag agcaggaagg ctcatttctc 2901301 gtcggagtgg ccgcagccct atcaagcaaa tcaggaaaaa tcggctttgt aggcggcatg 2901361 gaatcagagt tgatcaaaaa attcgaggtc ggcttccgtg ccggcgtgca agcagttaac 2901421 cctaaagccg ttgtagaagt gaaatacgca gggggtttcg ataaagccga tgtcggtaaa 2901481 gcaaccgccg aaagcatgta taaatcaggc gtagatgtta tttatcactc tgcgggcgcc 2901541 actggcacag gcgtctttac tgaagcgaaa aacctgaaaa aagaagatcc aaaacgcgat 2901601 gtctgggtca tcggtgtcga taaagaccaa tacgcagaag gccaggtaga aggaacagat 2901661 gataacgtca ccctcacttc catggtgaaa aaagtagata cagtcgttga agatgtaacg 2901721 aaaaaagcga gtgacggaaa gttcccgggc ggcgaaacac ttacctacgg gcttgatcaa 2901781 gacggagtcg gcatttctcc atctaaacaa aatctatcgg atgatgtgat caaagcggtc 2901841 gataaatgga agaaaaaaat catcgacgga ttggaaatcc cggcaactga gaaagagctg 2901901 aaaaccttca aagctgaata agaatcgcag ggataaggag gtcgagccct tatcccttgt 2901961 ttttctttta ttttgaaata aaggagcggt caatcaatgg aatatgtcat tgaaatgctc 2902021 aatatccgca aggcgtttcc aggtatcgtc gccaatgaca atatcaatct tcaagtcaaa 2902081 aaaggcgaaa tacacgcgtt gctcggtgaa aacggagcgg ggaaatcaac attgatgaat 2902141 gtccttttcg ggctgtatca gccggagcgg ggtgaaattc gggtgcgcgg cgagaaggtg 2902201 cacatcaaca gcccgaacaa agcgaatgac cttggaattg gaatggtgca ccagcacttt 2902261 atgcttgttg acacctttac agttgctgaa aatattattc tcgggaagga gccaaagaag 2902321 tttggcagaa ttgaccggaa gcgtgctggc caagaggtgc aggacatttc cgatcgatac 2902381 ggcctgcaga tccatcctga agcaaaagca gctgacatat cagtcggtat gcagcagcgc 2902441 gcagaaatat taaaaaccct ctaccgcggt gccgacattc tgatttttga tgaaccgacg 2902501 gctgttttga cgcctcatga aattaaggaa ctgatgcaaa ttatgaagaa cctggtcaaa 2902561 gaagggaagt ccatcatctt aatcacccat aagctgaaag agattatgga gatttgtgac 2902621 cgcgttacgg ttatccgtaa aggaaaaggc atcaaaaccc ttgatgtccg tgatacaaac 2902681 caagacgaac tcgccagtct aatggtcggc cgtgaggtat cgttcaaaac tgaaaagaga 2902741 gctgctcagc cgggagcgga agtgcttgcg attgacggca taactgtaaa ggatacccgc 2902801 ggaatagaga cagtcagaga tttgtctctt tctgtcaaag cgggagaaat agtcggcata 2902861 gcaggcgtcg acggaaacgg gcaatctgag ctgatcgaag cggtgacagg actccgcaaa 2902921 acagattcag gaacaatcac cttaaacgga aaacagatcc aaaacctgac gccaagaaaa 2902981 atcactgaat ccgggatcgg gcatattcct caggatcgcc ataaacacgg tctcgtcctt 2903041 gattttccaa tcggagagaa tatcctgctg caaagctatt acaaaaagcc gtattcagca 2903101 ttgggcgttt tacataaagg cgaaatgtac aaaaaagcac gcagcctgat cactgagtac 2903161 gatgtcagaa cgccggatga atatacacac gctcgggcat tgtcaggcgg aaaccagcaa 2903221 aaagcgatta tcgggcggga aatagaccga aatcctgatt tattaattgc cgcccagccg 2903281 actcgcggcc ttgatgtcgg agcgattgaa tttgtccata aaaagctcat tgagcagcgt 2903341 gatgccggga aagccgttct tctcctctcg tttgagcttg aagaaattat gaatctcagt 2903401 gacagaatcg ccgttatttt tgaaggacgc attatcgcca gcgttaatcc gcaggaaacc 2903461 actgaacagg agcttggtct cttgatggca ggaagcacgc aaaaggaagc ggggaaagca 2903521 aatggttaaa cgactctctc atttactcgt gccgctcatc gcaatcatac ttggtcttgc 2903581 ggccggcgcg ttgattatgc ttgtgagcgg ctacagtgtg gctagcggat attcggcttt 2903641 gtggaatggg atattcggag aaatctatta tgtcggagaa acaatccggc aaattacgcc 2903701 ttatatttta tccggattgg ctgtcgcctt tgcattccga accggactct ttaatatcgg 2903761 cgtcgaggga cagctgctcg tcggctggac agcagcggtt tgggtcggta cggcgtttga 2903821 cggaccggca tatattcact tgccgctcgc attgattaca gcggcagctg caggaggatt 2903881 atgggggttt attcccggca ttttgaaagc gcgattttac gttcatgaag tcattgtcac 2903941 cattatgatg aattatatcg cgctgcacat gaccaattac atcatttcaa acgtcttgac 2904001 agatcatcag gacaagacgg ggaaaattca cgaatccgcc tccctccgct ctccttttct 2904061 tgaacagatc accgattact cacggctgca tttgggaatc atcgttgccc ttctcgcagc 2904121 agttatcatg tggtttatca tcaacaaatc tacaaaagga tttgagctcc gggcggtcgg 2904181 gtttaaccag cacgcttccc agtatgccgg catgagcgtg cggaagaata tcatgacctc 2904241 catgcttatc tccggcgctt ttgcaggtct tgccggagcc atggagggcc tagggacatt 2904301 cgaatacgca gcagtgaaag gcgcatttac cggcgtaggc tttgacggta tcgctgtcgc 2904361 tcttctcggg ggaaacacag ccgtaggcgt tgtactggca gcatgcctgc ttggcgggct 2904421 gaaaatcggc gcattaaata tgccgattga atcaggcgtt ccatcagagg tcgttgatat 2904481 tgtgattgcc attattattc tatttgtggc ttcaagctat gcgattcgtt tcgtcatggg 2904541 caaattgaag aaaaaggggg cgaactaagt ggacattgtg cagattttat ctatcattgt 2904601 ccctgccaca ctcgtctatg cggccccgct tattttaact gctctcggcg gcgtgttttc 2904661 cgagagatca ggtgtggtga atatcggcct agaaggcctc atgattatcg gggcgttcac 2904721 cagcgtgtta tttaatttat tttttggtca ggaattaggt gccgccgcac cttggctttc 2904781 gctccttgcc gccatggcag caggcgccct gttttcactg attcacgcgg cagcggcgat 2904841 ttcgtttcgc gccgaccaga cagtcagcgg tgtcgccatt aacatgctgg cgcttggggc 2904901 aactttattt atcgtcaaac tgatctacgg caaagcgcag acagacaaaa ttccagagcc 2904961 tttttataag acgaaaatcc ccggtttggg cgatattccc gtcttgggaa agatcttctt 2905021 ttcggatgtc tattatacgt ctattcttgc aatagcactt gcctttattt cctggtttat 2905081 cttgttcaaa acgccgttcg gccttcgtat ccgttctgtc ggcgagcatc cgatggcggc 2905141 cgatacgatg ggaatcaacg tatataaaat gcgctacatc ggcgtgatga tcagcggatt 2905201 gttcggcggt ctcggcggcg gcgtatatgc ctccacaatt gcgcttgatt tcacgcactc 2905261 taccatctcc gggcaaggtt ttatcgccct ggcagcgctt gtattcggaa aatggcatcc 2905321 gatcggagca ctgggggccg ccctgttttt cggattcgcc caaagcttaa gcatcattgg 2905381 atcgctgctc cctcttttta aagacatacc aaatgtgtat atgctgatgg ctccttatat 2905441 cttaacgatt ctcgctttaa ccggctttat cgggcgggca gatgcgccaa aagccaatgg 2905501 cgtgccttat attaaaggaa aaagataaac attctcccct gggaagacga ttctcaggga 2905561 tttttttcta atccaaaaga cccccttaat ttaattgttt attagttttt taacttaaaa 2905621 aaatatgaag tgttaacgct ttcttgtaga ctgtaacaaa caatacatgg gggtgtatga 2905681 catgggagca attccaaaaa cggggacaat ttcacctgag caaaaagact cacaggagaa 2905741 aaacctgttt caaaaaattt ggtcttggga aatcggtgtg attcctttgc cattatacac 2905801 agtattagct gttattatta ttcttgcagc atattacaat gagctgccgg caaatatgct 2905861 tggcgggttt gccatcatta tgattcttgg tgtgtttctc ggagacatag gccaacgcat 2905921 accgatattg aaggatattg gcggccctgc tattttatct ttgtttgttc cttcattttt 2905981 agtcttttac aatgtactga attcaacatc tttagacgct gtaaccaact tgatgaaaac 2906041 gtctaacttc ctttatttct atatcgcttg ccttgttgtg ggaagtatcc tcggtatgaa 2906101 cagaattgtt ttaatacagg ggtttatcag aatgttcgtt ccactggttg caggaacgat 2906161 cgcggccgtt gcagccggca tccttgtcgg atttattttt ggctatagtg cctatgattc 2906221 ctttttcttt gttgttgtcc cgattattgc cgggggaata ggtgaaggga ttttgccgct 2906281 ttcaatcgcc tattcacaaa tactgggctc atccgccgat gtatttgtgt ctcagctggt 2906341 gccagccgca attataggaa acgtttttgc tatcatatgt gcagccttaa tgaaaaagct 2906401 tggcgacaag cgtccagatc taaatgggaa cggacgtctc gtaaaatcta aaaaagcaaa 2906461 tgagattttc aatcaaaaag aagccgaagc aaaaattgat tttaaactaa tgggagcagg 2906521 agttctgctc gcgtgtacat tctttatttt tggcgggtta ttggagaaat tcatcttcat 2906581 cccgggcgcg atcttaatga ttatttcagc tgcggctgtc aagtatgcaa atattcttcc 2906641 gaaaaaaatg gaagaaggcg cttaccagct ttataagttt atttcttcaa gctttacatg 2906701 gccgctgatg gtcggtctcg gcatcctctt tattccgttg gatgacgtag cgtctgtgat 2906761 ttctataccg tttgtcatca tctgtatttc agttgttatc gcgatgattg gttctggata 2906821 tttcgtaggc aagctgatga acatgtatcc ggttgaatcc gcaatcgtta cctgctgcca 2906881 cagcggtctc ggcggaacgg gtgatgttgc cattttatcg gcatcaggaa gaatgggcct 2906941 tatgccgttt gcccaaattt caacccgtct cggcggtgca ggcacagtta tttgcgcgac 2907001 agtgctgctt cgttttttca cttcataaac agaaagagtt ccgttttatg cggaactctt 2907061 tttttattta ttcacaatcc gaatatactc tcggggacca aacggcagat cctttgattc 2907121 cgtctcactc attctggctg acaggtggtg ctccagtaaa tacagctccc actcatcaca 2907181 agccgccaca ccgctgcgcc cgtcatattg attcaacatg aatgcccctg caaatactga 2907241 gcagaataaa cctgagcaca tcacgacttt tgttttcaca tgaccagctc ctttccttca 2907301 gcttgatcag gattgatttt aaatatacaa ataacctctt ttttgttaga cttattttga 2907361 ggtcaaaaga actcataaaa atccattaca gcagttcgaa gcgtggcagc ttgcagaaaa 2907421 gtgcgatata atttggacta ggtcgtttga ccgtatattt tatacatagc gcatttttca 2907481 attgagaacg agaaaaggag gtcttatctt tgcagctctt acatcttgct attttatcgc 2907541 cttttttatt tgcttttatc attcccttct tggcaaaata cgcaaaaaga gtgcatacgg 2907601 gctggtttgt gttgatcctg cccgtcttgc tgtttatata ctttctccca atgatcagga 2907661 tgacgcaatc tggagaaaca cttcgatcgg tattagagtg gattccgtca ctcggcatta 2907721 actttaccgt ttatatagac ggcctcgggt tattattcgc tttactgatc acaggcattg 2907781 gctctttggt cactctttac agcatttttt atttatcgaa agaaaaagaa cagcttgggc 2907841 ccttttatgt ctacttattg atgttcatgg gcgccatgct cggcgtcgtt ctagtagaca 2907901 atgtcatggt tctctacatg ttctgggagc ttacaagcct ttcatccttt ttgctgatcg 2907961 gctattggta taagcgggaa aagtcgcgct atggcgcagc caaatcactt ttgattacgg 2908021 tcagcggcgg gctgtgcatg ctcggcggat ttattctcct ttatttgata acggattcct 2908081 tcagtattcg agagatggtt caccaggttc aattaattgc cggccacgaa ttgtttatcc 2908141 cggctatgat tctcatttta ttaggggctt ttacgaaatc ggcgcaattt cctttttaca 2908201 tctggctccc tgacgcgatg gaagctccga cgcctgtcag cgcttatctc cattcagcta 2908261 ctatggtaaa agccggcatt tatgtgattg cgagattcag tcctattttc gccttttcag 2908321 ctcagtggtt ttggatcgtg tccctcgtcg gcctctttac gatggtttgg ggttcattcc 2908381 atgccgtgaa acaaactgat ttaaaatcga ttttggcgtt ttcaaccgtc agccagctcg 2908441 gcatgatcat ctccatgctc ggagtcagtg ctgcggccct tcattacgga catacagaat 2908501 attatacagt tgccgctatg gctgccattt tccatttgat caaccacgca acctttaaag 2908561 gaagcttgtt tatggcagtc gggattatcg atcacgaaac aggcacacgg gatatccgga 2908621 agctaggcgg cctgatggcg attatgccga ttacttttac catttcctta atcgggacat 2908681 tttcaatggc cggcctaccg ccgtttaacg gatttttgag taaagaaatg tttttcacaa 2908741 gcatgcttcg cgtgacacat tttgacctgt tcaacgtgca gacatggggc gttctgttcc 2908801 ctcttttcgc ctggatcgga agtgtattta cgtttatcta cagcatgaaa ttgctgttta 2908861 aaacattcag aggaaattac cagcctgaac agcttgaaaa acaggctcac gaagcgcctg 2908921 tcggtatgct cgttccaccg gtcattcttg tcgctttggc tgtcagtctc ttctttttcc 2908981 cgaatatatt gtcgtacagc ctgatagagc ctgcgatgaa ctcaatctat ccgacactgc 2909041 ttgacggcca tgagaaattc cacgttcaca tttcacagtg gcatggggtt acaacggaat 2909101 tgctcatgac tgcgggtatt gttgtgatcg gaacaattgg ttatttgtcg ctgaataagt 2909161 ggaaaggaat ctataaactg tttccttcga aactcacact caaccggtta tacgataagc 2909221 ttttgactat gatggagaaa ggctcttacc gggtcacaaa acaatatatg accgggtttt 2909281 taagagatta tttgctgtat atcttcgctg gtttcatcat tctgataggc ggagcttttg 2909341 ccattaaagg cggattttca tttaaaacgg aaggcatggc taaaatcggt gtatacgaaa 2909401 tcattttgac gcttgtcatg atcagcgcca cagtggcgac tgtttttgct aggtcaagac 2909461 tgacggcgat cattgcactc ggtgttgtcg gttatacgct tgcattgttt tttgtcattt 2909521 tcagagcgcc ggacttggca ttgactcagc tcgtcattga aacgatttct gtggcactgt 2909581 ttctgctttg cttctaccat ttgccgaaac tgaggctgaa aacaaaaacg agaacgttcc 2909641 ggatgacgaa ttttatcatt tctttaggcg tcggtgttat cgttacactg ctcggcatcg 2909701 catcctcaag ccagcggaca aaagacagca ttgcgtcctt ctttgtcaaa cacagccacg 2909761 atctcggcgg aggggataat gtcgtcaatg tcattctcgt tgatttcagg ggatttgata 2909821 caatgtttga aattacggta ttaacgatag ccgctctcgg catttacagc atgattaaaa 2909881 caaaagtaaa agaggagggg aaaagcggtg aatgaacaaa aaacaaatga cttgattctt 2909941 caaaccgcga caaagcttgt atcctttatc attttgcttt tctctttcta tttattttta 2910001 tcagggcata acgcgcccgg aggaggcttt gtcggcggac tgatcacgtc ctcttccatc 2910061 gttctcttgc tcttggcata tgatttaaaa accgtgcgtt cccttttgcc tgtcaatttc 2910121 atttatgtcg cgggagccgg ccttctgctc gctgtattaa caggcgttgg ctcctttgtc 2910181 ttcggggctc cttttttaac ccacacattc ggatactttc agctgccgat ccttgggaaa 2910241 acggagctcg ccacagcgac gatatttgat ttaggcgttt atcttgttgt cgtaggcata 2910301 acgatgacca ttattcaaac gattggagag gaagaataat ggaaatctta atggctgtat 2910361 tagccggtat tatttttatg gctgctacgt atttgctgct gtctaaaagc ctgcttcgcg 2910421 tcattatcgg aacagcactg ttaagccatg gcgttcattt aatgcttttg actatgggag 2910481 gattaaagaa aggcgccgct ccgattttga gcgagcatgc caaatcattt gtcgatccgc 2910541 ttccgcaagc cctgattttg accgcaattg tcatttcttt tggcgttacg tcattcatcc 2910601 tcgtcatggc ctttcgcgct tatcaggaat tgaaatcgga cgatatggat caaatgaggg 2910661 gaaatgatca acatgaataa ttttgttatt ttgccaatcc tgatcccgct tttgtcggct 2910721 attcttctga ttttcatgac gaagaatctt atgctcatga gaatcttcag cacggcggca 2910781 tcggccatcg ggattgtgat tagcggcata cttgtacaga ctgtcttcac aaaaggcatc 2910841 cagacactca gcctaggcgg atggaaagcg ccgtacggca ttgtgcttgc cgcagaccaa 2910901 ttcgccagcc ttctcgttct cacaacagcg atcatcggtt tattggttgg gctttattcc 2910961 ttccgttctg tcggtgaaaa acgggagcgc tccttttact actccggcgt tcagttcttg 2911021 cttgccggcg tcagcggagc gtttttaaca ggcgatttat ttaatatgta cgtatttttt 2911081 gagcttctgc ttattgcttc ctatatgctg attgtattag gcggcacaaa aattcagctg 2911141 cgggaatccc ttaaatatat tgtgtttaat attgtatcgt ctgccctgtt tgtcataggg 2911201 gtcggctttt tatacgctgt aaccggtacg ttaaacatgg cggatcttag cgtgaaaatc 2911261 agcgaatcag gacaaaccgg gctgatcact gtgattggtg tcctgctgct tttggtattt 2911321 ggcatgaagg gcggaatctt ccccctctac ttttggcttc caggctctta ttacgcgcca 2911381 ccggcggcaa tctccgcgtt gttcggcgct ttgctgacaa aagtcgggtt atatgcgatt 2911441 acgagggttt tcacattgat ttttattcac gatacagcct ttacccatca gttgatgatt 2911501 tggctggcgg cgctgactgt gatttttggt gtgatcggtt cactcgctta ttcgaatgtc 2911561 atgaaaattg tgatctataa cattattacc gctgtcggcg tgattttgtt cggtgtggca 2911621 gtacacaccc ccgcatccat tcagggcgcg atctactatc tgattcacga tatgctgatt 2911681 aagggcgctt tgttcatgct ggcaggtacg ctgatcgcat tgactggaac cgcgagcctg 2911741 cataaaatgg gcgggctgat caaacgctat cctgttcttg gatggatgtt tttcatttcc 2911801 gctatttctc ttgcaggcat tccgccactg agcggatttg tcggcaaatt taaaattgca 2911861 gagggcggct tcgcagaagg tgaatttacg atatccatgc tgattctgct ttcgagtctg 2911921 cttgtactgt actctgtgct gaggatcttt atacatgcgt tttggggcga agaaaaagaa 2911981 acgccaaaac caaatcatcg aacagctaaa ggacttcttt atccggcagc tatttttctc 2912041 ttgctgtccc ttctcttcgg attgggtaca gaatgggtgt cgccttacgt tgatcaagcg 2912101 gccgagacgc tgctgaatcc ggaaaaatat atcgaagctg ttctgaagga gtagatcgca 2912161 tggcatttca aattttatta aatgtgtttc tcgctttttg ctggatgttc ttaagcaaca 2912221 gtccaagcgc cgcaggattc attacaggct atattctggg aatgctctct ctctttttct 2912281 tccggcgctt tttcactcgc cagttttatc tatggaaatt gatttctatt atcaagctct 2912341 gtttcatttt tataaaggaa ctgtaccttg ccaatgtcag tgtgatgaaa tcagtcttat 2912401 ctccaaaact gaatatcaga ccgggtattt ttgcttttaa aactgaactg acgaaggact 2912461 gggaaatcac catgctttct ctgctcatta cattaacgcc gggaaccttg gtgatggata 2912521 tttcagatga cagaacaata ctttatattc atgcaatgga tatcgaggat gcggaaaaag 2912581 cgatttttga cattcgggag tcatttgaaa aagccataca ggaggtgagc cggtgatgtt 2912641 tacgctgatc ctgcaaatcg cgctcggcat tatggcagtg tctacctttt tgtatgtcat 2912701 tcgtgtcatt aaaggtccga ctgtgcctga ccgggtcgtg gctctggatg caatcggcat 2912761 caatctgatc gcaatcacgg cgcttgtctc cattttgctg aaaacaagtg cgtttttgga 2912821 tattattttg ttgctgggga ttttatcgtt tatcggaacg atcgcatttt ccaagttcct 2912881 ggagaaagga gagattatcg aaaatgatcg aaaccgctaa ggtcgttgtg gctgtattca 2912941 ttttgctggg tgctcttata tgcctcattg cttcatttgg cgtacttcgc cttcccgatg 2913001 tgtttacacg cgctcatgct gcttctaaag gctcaacatt aggtgtcaat atgattctgc 2913061 tcggtgtctt cttctatttg tggtttgtga cgggggagct ctccgctaaa atcctgcttg 2913121 ggattctctt tatctttatt acgtcgccta tcggcgggca cttgatctgc cgtgctgcgt 2913181 ataactccgg cgtcaagctt gatgagagaa gtgtgcaaga tgactataac ggaatcagaa 2913241 actttgtgat taaacgaaaa gaggattctt atttataaaa ataagcagcc ggacaggcag 2913301 agttccggct gtttttttat ttcttgatga cagccagcgt gcatctggat atacagatca 2913361 gcctctcttg ctcgtcatat atgtgaatat gatagacaat cgtcgttctg cctatatgaa 2913421 cgggctcggc tatcgccttt accgttcctt cctttacaga ttttaaatgg ttggcgttaa 2913481 tctccaaacc aacacaagct tgcgttgtat gatcaatcag gttctgtgca cctgcgctcg 2913541 ccgcggtttc cgccagggcc actgaagcgc ctccatgcaa atatccgaac ggctgtaccg 2913601 tccgatgatc caccggcatg accgcaacgc atcgttccgc tgtgttttca acaatctcaa 2913661 taccaagcgc ttcaagcaat gtgtgcttca tatccatctc tacacccccc aacatttaaa 2913721 gtacaccgtc tgatttcgca atcaaaaccg cttccgtccg tgaaccgaca ttcagcttat 2913781 tgaaaatcga tgtcaagctg tattcaatgg accgcttgct taaatgaagg gcatctgcga 2913841 tttcttggtt tgtaaatccc ttttcaactt cttgaagaat caggcattct ctaggtgtga 2913901 gcacatcttg ttctttttga gaggaaggag ccggctttgt tttttgctga gtcatcagct 2913961 gtttaaagta agcaaaatcg actaaaattt ctccgttgag tacgtggtat atgtattggg 2914021 tgatcttttc tttagattcc gttttgctga tggcaccgtg cagacccgca cgaatcgctt 2914081 cctcgaaata atcctcgacc tcataaccgg tatacacgat aattttacaa tgaggattct 2914141 cttgtaaaat ctgtttagaa agctccatcc cattgacctc gccgcctaga ttcagatcca 2914201 ttaaaatgag atcatatgac gagaaatcat gctgcttgat aaactgttcg ctcggttcag 2914261 gactgagaca atcaacagac aaattcgaat ccgtttccaa aattgtcttg gtgccttcca 2914321 tgacagccgg atggtcatca atcactagta tctttttcat gttttcctcc cttttactca 2914381 ctcttttcca ttttataaaa aagacttggc ctgtgccaag tcgtttccgt tataaatcca 2914441 ttacaattcg atttcaatat cagccttaaa gccctttcct tcacttgttt caatccgaag 2914501 gcgcccatct aaagccctga ctctctcctt aatgccagaa agccccatgc tcatggaatg 2914561 ctcagtattt ttttcttgat caaacccaac gccatcgtcc tcataatgaa gaacgatttt 2914621 gttttgaata ctgatgagca taatcagcac atccgtcgcc tgagagtgct tgaccgcatt 2914681 agacagaaac tcttgaatga tccggtacaa attcagctgc gaatccagat caagggaagc 2914741 cgtaaatctc ccggtattta aacggatatg aaacggaacc cgctcctgct gctgcgccac 2914801 cagcttcgac agcgccttca ccaatccaag atcatacaga agctgcggcc gcagctcatg 2914861 acacgtctcc ctcgtcatcg aaatcacatc agacatctgc tcattcatct gtacaagctt 2914921 gtcctgcacc tcttcacggc acggattatc atccttcttg aaatcaccca aaaacagctc 2914981 acactggcgt tttaaggaaa tcaaatcctg aagaaccgaa tcgtggagat cgcgggcgag 2915041 tcctgaacgc tgtttttctt cgattgcaaa cattagcttt ttcagccaga tggggttggt 2915101 tccctcttgt tttaagtcct tcaaatgttc catgagctcc tcaatatgca ggacattttc 2915161 catggacaca cttgtataaa aagacagtgt tttcagccac gatatttcat cacgtgttag 2915221 ccggggagtg ttaatattag ataaacaaag cagaacataa gaactaccgc ctcgttcacc 2915281 aactttcata agaaagcctt gattgacttc tataattttc ccaatttctg aagttacgtt 2915341 ttcaaattcc tcttgataaa aattccagtc cggtccaact tcatgcttat ctaaaaatat 2915401 cactttgtga tcaggagtaa cctcaaaggt ataagctttg cttacaagca aaacatccag 2915461 tatagtattt ttcagttctt taaaaacttg ttgaagagaa gttacacccc tcattagctg 2915521 agtatattta aaaatactgt cctgatagtt gaatttttcg gagaaacgtt ttaaccgaaa 2915581 tttaaaatcc atgacctctt taaaataaaa gacagcgaac atgacaacga aaaaaaatac 2915641 agtttgacgc acagggttca tctggatgtc cattacatca aacagaacta atgcaccaac 2915701 tattagaaga gttggtatca tggcaagtag agcatagtat ctcattcttc ctaagataaa 2915761 ctctatatca aacatcttat tggctacaaa ttggtatact aacccgaacg gaattagtac 2915821 tagtaatgac gccgaagcta atgccgggaa aatataatta cctgtaaata ttattggaag 2915881 aacaaaaaat atcaaaaaag gcgcaaatga aagagtgttt gttaaaatta gtaatttaag 2915941 aataaacgaa tgctcagcat atttatattt attaagatgt aagtatatcg ctgaaaaaga 2916001 aaatagagtc aaagttgcaa aagaaaccaa attaagagtt gctaaaaaat caatatctac 2916061 ttgtaaatag tcttgaaaaa actcaatacc aagattaaat attggtatga tataaagaaa 2916121 agaaattcta ttcaaaaaag ttttacctat ttctccaagg tatctttgta taaattgaag 2916181 ataaagaata ggagaagata taaaagtaaa caagttaata taccgattga ttatatgtcc 2916241 tctaaatggt ccgcctgcac ttatatatgc tatcgaaatg tctaataaca atagaataag 2916301 aatataggca gcaaatgatc tccttttttt atttacttta agtatataaa aaatacatat 2916361 tatgcttaaa aaataaaaaa acaaaggaag tacgaacaga aaaaaactat aaggtctatt 2916421 tagagtaact aaatcaaaat ctttgagatg aatctttttt ccacttctca aaatatccag 2916481 actgttaata tgactcaaat atccccattt caaatgtttg tctgaaggtt tttctttatt 2916541 aatttttaat atgatgtctc cctgtctcag accaacaaat tgtccatatg aagattccga 2916601 tatttcttct atcataaatt gacttttatc atttttatga atcttagtcc caataataat 2916661 tccattcata ctgatataag ttgtatagct tatataaagg atactcaaaa caattacagc 2916721 tattgtgaat ttttttatta agttcttcaa tattaatcca cctattaatc accccattga 2916781 cgggttattg gatcagccag ataataatca ttataagctt taattattgt ttcagtttct 2916841 tgcacatcaa aacctataag gcaggcttct ttatttttca atttttttaa agcctcagga 2916901 taatttaaaa agtagttaat taggtcttgc atcttgtatc cccctttgta taacttaata 2916961 agcattcctt tattagctct ttttttcttt atctaaattt aattgttcta tagcagaaat 2917021 acatttctgt ttatatattt ccaataatac cgaaatgtat tgagtaactc ccgctttaat 2917081 taatttttct tggaatttct ctttatcaag taacgattta taatataagt ctttatgtga 2917141 aattaagtat aataaatctt ccgaagcatc attaaaaagg cgcttaagat ataagtaaat 2917201 cagtgtatgt ttgttttttt caatatcact gcgatttccg gataaaagaa cataataatc 2917261 tccagaaatt tgagctataa tccctttata gtaggaatat ctttcaactg tttcattata 2917321 ttctcctgta gccaataaaa cacctgctac atttgctagt gcaatcagac ttccacattt 2917381 taatctaatt acttctaaac tttcatcttc tgttttagat ttattagtga tatcgtcatg 2917441 ttgaccttgc atggcctcgt ttacgtattt taaaacatat ttaaaaatta gaggattgtt 2917501 atttaatgaa taaatactcg ttaatcctac tgtatacaag gaaagtgctg catttaacga 2917561 ctccgagcga ttaattttca tccataatgc atggtgatta tcttcatctt caagatcatc 2917621 cataatatct gatgaaagaa taagaatttc tattcccgcg ccaagccttg ttgcaacatc 2917681 taaattctcc cctccaaaaa caacataatg taagattgtg gattcagcaa aggagaatgt 2917741 ttctttagaa tcaataaatg agtaaagaag ttgtgacaaa tcctcgttaa atatgttttg 2917801 ctccacaatc tccttcattt tctccttgat ccggacagaa tctaaacata tctgctcaat 2917861 aacgacttcc cccctcccat tccattttac taaatgggac atttaaagga cagcaggttt 2917921 ttcgtttttt aacaatcata taatacttta tccatttatt gtatcggtag aacgaaaaaa 2917981 aagacttgtt tccaagtctt tttcacgaaa ttttcattgc ataattgtat ttatcgagtt 2918041 gatcaatgct tttgttaatg tttcgtaatg aatctgtcgt ttctttaata tcaagttcga 2918101 gtcggaataa caattgtttt acttcttcaa gtttcttttc catcgtttcc acactccttt 2918161 ttttgaaaga tcaatgaatt gtgtatggtg aacgagtcct aggtatttga tctgttacta 2918221 atagtgtgtc tgctttcggc tcatttttca ccgaaaagta tgcaaaaaag tcctgcgtga 2918281 caccgcaaat ctcaataggt ccttatactc aaaggaatca caacaagaac gggactatct 2918341 ttctatgcga aagagcgttt atatgtgctg aaattgagaa agattcttaa tctccttgat 2918401 tttaacgggt ttcgcatttt cactaagcaa gactatagtc cttcataccg tattttcaaa 2918461 attgaatatg cgattcttgg cgtttcctga ccgacaaaca ccgaaaaaga ccgcaacgct 2918521 aaagttgtgg ccttttcgct ttgtcatatt cggcaattag ggatctatac atatagaaac 2918581 atcctttttt gcgaggtgct cccatgagat atcgttatcc ctggttttac gtgtatccgt 2918641 atgaggtacg ccgtccgccc gctcctgcca acaatattga tacctttatc cgttcagcga 2918701 agcaggccgc agggatattt gcggatgccc agctcgttct cagccgcatt gcgggctcgc 2918761 gggagctttc gcgccgcatt ctgaccgcag ccgaacagtc tgataaacaa actataaggc 2918821 gcctgatcaa acaaatgggc gtccggcatg aagtggatac ggtctttaat cccgacggca 2918881 tctatatcag ccttatcgga acgcaaagcc gaatgattct tgctttgcgg tggtcagagg 2918941 accgcaatca ttttgcgtcc ataagattat gacaccattc cagagcctct aaataacatt 2919001 catacgcttc ttctttgtcc agttgattgc ctaattctga gcaagtgtcc cagttgttgc 2919061 tttcaattaa tttcacaagc tcaagcattt ggtagtagtc gttttgatgg cctaataatg 2919121 cttgcccgac ttcatctttt aaaggcaatt cttgaacaat ttcctctatt tctctatgca 2919181 ggagggtgtc tatgagagaa aacattccga tcagcatata agaagcaggc tgcggccggg 2919241 atgtctttct cgccagcagt tcgcaaagct ttgctcttat cagagaaatc ttaatgattt 2919301 cgtgcttgct ggaatgccct ttcctgctta aatccttaaa ggaaagaata tatatccacc 2919361 gtttgatttc attaaatccc agcagcataa tggcctgttg aatgctttca attttctggc 2919421 tcaaacggct gtgggatgag tttaaaaatt ttaaaatttg ataggacagt gataaatccc 2919481 gctctatgta ctctgtcaca cgctttatgt taggctgctc tttactcagt tcgttaagca 2919541 gttcatagta agaatagaaa tgagtcgata ggtcatgccc gctgatgatg cgcggctcgc 2919601 tgaaaaagta gccttggaat aattgaaagc cgtcttggac cgcctgttta tattcttttc 2919661 gggtctctac tttttccgct aaaaaaatca ggccgcggca gccgtaggtt tgcaaaattg 2919721 ttctgcgttc cattcgtgtt gttttgagaa aatcaatttt caatatatca atatagctca 2919781 tgagtttttc cagtaagtcc tcatcttgcg gatttattgc ataaaaatca tcaagcgcca 2919841 gcatataccc catttttttc aattctttgc atctagaaat gagggccggc gtgatcggta 2919901 tatcttcaag gatttcaatg acaagctgtt tcggattgaa ggaggtggga agattcgaaa 2919961 acatcaggct ttccgtaaaa ttaacaaaac agcgtttccc ttccgtcagc ttctcaattc 2920021 cgatgtttaa aaagctgttg atcaccaaat ctgttgttgc ctgatcgccg tctttagcgc 2920081 tatacacgtt ctcttcgctt tctctataca gcagttcata agcaacaacc tgttcttttc 2920141 tattaaaaat aggctgtctt gcaacaaaca ccctcattga tttatccccc ttacaatacg 2920201 cgcggctttc acccctaagt atatcaaata atttgacgaa aattgtctaa acatgaaaaa 2920261 taatatatac ataaagaaaa ctggcccttc gcgaatgaaa ggccagtttt tctttattct 2920321 tcctcaagct cttcttcaat tctgcttttc acttcgtgga tccgctgcat tttattgctc 2920381 cagcagtcct cgcttaaatc aaccgggtat tcctccggct tgctgattct cttatattcc 2920441 tcccaaagca ggctgaggtt atcctgcaca tactgctgta tgtctgaaat ctcagggttt 2920501 tggtagcaaa gaataccctt ctcaaaaatc agttcatgaa gatccttcgc ataaaaattc 2920561 gtgacaaatt tgctgatgaa tgtatgaacc gggtggaaca ttctgagccg cttctgatca 2920621 ttcacctgct catcataaag cgcaatatag tcgccttcag aatgatggtt ggactgatta 2920681 ataatgcggt agactttctt tctgcccggt gtcgtcactt tttcaggatt ggacgaaatt 2920741 ttgatcgtgt cgaccatttt cccgtcttct tcaatggcaa cgagtttata aactgcgccg 2920801 agagccggct ggtcataggc agtgatcagc ttcgtaccga caccccagac atcaatgcgc 2920861 gctccctgag cctttaaatt cataatggtg tgctcatcca aatcgcttga agcaatcacc 2920921 ttcgcatctg taaatcctgc ttcatcaagc attttccggg ctttttttga caggtacgcc 2920981 aaatcgccgc tgtccagacg gatgccaatg aaattaatgc ggtcgccgaa ttccttggca 2921041 accctaatcg cgttcggcat gcctgaacga agcgtgtcat acgtgtcaac taagaagacg 2921101 caatccttat gtgtttccgc gtattttttg aaagctgtat attcatcgcg gtaagcctgc 2921161 acaagcgcat gcgcatgtgt gccggaaacc gggatattaa agcgctttcc ggctcttaca 2921221 ttgcttgtcg cgctaaagcc gccgattaag gctgctctcg ctccccacat ggccgcatcc 2921281 atttcgtgcg cccgtcttgt tccgaattca agcgcaactt catcaccgat gacgccttta 2921341 atccgggcag cctttgttgc gattaatgtt tgatagttca caatgttgag caaagctgtt 2921401 tcaatcagct gcgcttctac caggggtgcc tccaccctca taatcggctc attgttaaaa 2921461 acgagttctc cttctttcat ggagtaaagt gaacctgtaa aagataagcc gcgcaaatat 2921521 tcaataaaat cttcatgata cccgagttca tcctgtaaat aactcaaatc gctatccgta 2921581 aacttgaaat tttccaagta ttcaatggct ttttccaagc ccgcaaatac ggcatagcca 2921641 ttttcaaacg gaagccttct gaaaaacagc tcaaaaatcg ctttcttttc atgaatgccg 2921701 tctctccagt acgtttccgc catattgatc tgataaaggt ctgtatgtaa tgacaggctg 2921761 tcatctttaa atccgtactc taacactgtt tttccccttc cttactctgc cacttgcgct 2921821 ccgatgctgt ttgcaaaatg ggaaagagcc catgcgtgcc cctcctgatt aaagctggca 2921881 acagcttgtt tatgcacaac aatccgaaaa cctttgttgt atgcgtcaac agctgtatgc 2921941 aacacacaaa tatctgtgca gacaccggca agatgcagtt cgccaatctg ccgctctctg 2922001 agtttgagct ctaaatcagt tcccgcaaaa gcagaatatc tcgttttttc catgtagtaa 2922061 acattaggtt catgttcatg tttctgatat agaggcaaaa gctttccgta cagatctttt 2922121 ccttccgtgc cttttatatt atgcggagga aaaagacggg tttcagggtg atattgatcc 2922181 ccttcatcat gagaatctac tgctaatacg acgtaatcac cgtttgtgat gaattcttta 2922241 gttaaattga cgatcgcctc ttcaatcatt ctgccgggct ccccgcaggt caattttccg 2922301 tcactcgcca caaaatcatt cgtataatca atacaaataa gtgctttttt catagccggc 2922361 ctccccgcca tcagtatgag aacattatat cttatctcca gttgtaagtg aattgccatg 2922421 aacaaaaaga caaacggtcc gtttgtctct tacgatttca gtactgaccg attataaatg 2922481 tcgtcctgaa tatatatcaa ttcacgattc acagcgatat cagccgcaat gacgatgcct 2922541 aagggcgtat gaaactggag atcagataca atcttgaaag gcactccgta ccggctcgcc 2922601 atttggatat aagaagagta agactgatac tgaagctctc cattaatcaa aagggtgacg 2922661 ttatggctgt ttttcagctc gtgctctgcc tctttatacg gtttgcttct aagcacctgt 2922721 cctttcgtca gtgccaaaac gactctttct cttaaagagc ctaaaaacaa atggcgctcg 2922781 tcaggctttg tctccaaagg cccatacatt ccttgctgca aatagagatc cattttatct 2922841 tcactcaaaa gcctgtcctc ccgtcttgtt tgtcttcatt atcacctgat caggcaggag 2922901 ctaaactttc aagcgccgtt tacatttctg ttacccaatg aatgattttt ttggccagct 2922961 caccagcagg ggtttcctct gtatgccggc gcaacgacgc ttccagccgt tcaggcagag 2923021 ttgctttatc ttcttcatag gaaatgatcg tgctccactc cagctgcggt accgctacaa 2923081 gcgtgcgcag ttcttttctg ttttcatgca gatacacgtc cgtgatcatt ccggtttgcg 2923141 tattgatatt tgcttttctg attttcataa catgacctct ctattcaaag actacccata 2923201 ttatacaata aaaaagcaac agcctcttgt gaaaaggctg ttacccgtta aacgaaactg 2923261 tttcatcagt gatatcggca tctttgaaga gagttttact cgtttggttg ttaatcttca 2923321 caaaatcacc aagctgaaat gtgcctgacc ccgcccctga atgagcgacg cttttgggcg 2923381 aaatcgcaaa tacgtctcca aagcttgccg cggcattatc cgtaactgac atgatataaa 2923441 tcggccccac aattgcaggc atttccccac ctccgcattg atttacagca tcatatgcaa 2923501 ggagccgata atggtgcccg cctattcagc tggctttgcg ttttcctcga gtcgtgaccg 2923561 ctggcgcagc ttgatcaagc ggacaatatt caggaagaac gccttcacta ccgcataaac 2923621 cggcaccgct aaaatcatgc cgagaattcc gccgaagctt cccgctccga ttaatagcaa 2923681 aataatcgta agcggatggg tattcagccg ctttccgatc acaagaggag acagcaggtt 2923741 tccgtccagc tgctgaacga tgacgaccac aataatcgca aacagcgctt tggccggcga 2923801 gtccataaaa ccgacaatga cagccggcgc ggcaccgaga aaaggcccga catagggaat 2923861 gatattggta atcgccatga caatcccaag aatcagggca tacggcagtc cggcaattaa 2923921 atagccgata aaacacgctg ttccgacaaa aagacagatt aacagctgcc cctggaaata 2923981 tgccgcaagc gtatcggata aatctttaaa aatctttaag ccttctgtcc gataagaagc 2924041 cggtagaatt tttactgcca aatgcggaaa gcggtgtccg tctttcagca tgtaaaaaag 2924101 gataaatgga acagtaataa taacaagcgt gatgtttgtc acgacaccaa acaccgcaga 2924161 taaactggac gtgatatttt gcggcaggtt ttggagaaaa cttgtcaatg actgttcaat 2924221 ttttgatatc gatacataat cctggttcat catccaggta aaccattgag aatgggacaa 2924281 atcctttgtc agcgcctgaa tctgttttat ataatcagga aggttgttaa acagccctgt 2924341 cacctgtgcg gtgatgatag gtccgactga cgctgaaata aaggcaagca aaccgataaa 2924401 cagtaaatag atcaatagaa tggataatgt ccgcggaatt tttttctcaa gcaggcggac 2924461 gaccggatta aatatgaaat acaaaattcc cgcaattagc atcgggaaaa acaatgtcga 2924521 gataaaaaca ataaacggct gaaatacaaa tgaaactttt gttgctacaa aaataatcag 2924581 caaaacaaat aaaatctgca atgtccaaaa atggactttt gatttcaaca agctttgttc 2924641 ctcctagttt ttctttgtct gtcagataaa agaacttata ccccatcatt gtaacaaaaa 2924701 tgaactcata tcagaactct taatataatg aaaggagtgt tggtgatgaa ggccgtgaca 2924761 tacgatacag attcagaact ggcttatatc tatgttcttc ctccgaaaaa gaacaggaat 2924821 gtacggactg aggagctcag agtcaatgat tgtctcctgc tggatatcag ccaagatggc 2924881 aaaatcgccg gattcgaatg ttttggtgag gcagcacacc tctgtgcccc atttgccggg 2924941 aaatcccggc tgtatgtaaa agattcagac ggttatcatt ttcgggtctg ccagcatgct 2925001 tcagtccgtt cctgctatac ggtgtaccgt gtcactttct gtttttcaga tggtgactat 2925061 caggaatttg ccggctttga ccttgatgga acaatgtatc atagtgcgtt tttacagcgc 2925121 ttaactgaaa aataggacgt cctgttgtac gcctattttt catgcgcaag cactgttaga 2925181 cccgctcact gtaatctggg gtgacggaaa tcatgtgctg gattctgatc aaacaaacag 2925241 aatttcgggc tccttcaatt gtgatatggt caggttttac atcgatcagt ctgcctctga 2925301 ccgtatctcg tactgtctgt ataacgaacc ttgagccgat gagcttttta atggtctgat 2925361 agacataagg atcgactaaa gagaccagtt gcggactacc ttggttgacc atacttttat 2925421 cccctttgtg tgttttatct cagcttatgc cgcgcttatg gataatgaca caggcttacc 2925481 tgataaaaca aaggggtgcg gagattttag gagaatacgt ttggaggcgg gtgtaaagga 2925541 agtatcgatg aagcggagac agcgaagaaa gctggcgctg ttccgtactt atacaggctt 2925601 tatcacggat gcctgggctt ggtcgattaa ttggtccagc ttttctattt tttttcgtgc 2925661 ggttgaagga tcaatttggc ggtaatgatg gtggccgccc ggctcttcat ccagttcgtc 2925721 cgcttttttg acaatctgct gcagtgtgtt tttatctaat tcgccttcag gcaaatagga 2925781 atctgtatga agcaaaatgg ctagtgcaat ctcttttgct gctttcggtt cctcgccaag 2925841 ccgaatcaga agtttatgcg cccgttccgc ccctttaatg gcatgaatgt catttctttt 2925901 gtatttctca taatcccact ttccgtctgt ataccattca taatggccaa tgtcatgaag 2925961 cagtgccgct tttgctgcta aatcaggatt aatgtcagcc ttcacagaca gcctgtatgc 2926021 atgataagcg caggcaatcg catgtgccac gccggaacgc tgaagatatt tttgtgcaat 2926081 tggatgggtg aaaacatcca ttaatgtaac ctttctcatg gaaacccctc ctttagatat 2926141 ttttagaatc ctaacataat ttgcagagaa actcaattct tatgtcacat cattttgatc 2926201 ttcttatcat cattgttata ccctaaaagc aacgtttcag tcagtatatg cggctgttca 2926261 ataaaatgcg ctggctgcag ccttttgtat aaaaaaaaga gcagaaaata tctgctctac 2926321 aaaaactctt taatatcata aatgcggccg ttttccgtcc ctttttctag taaagaaagc 2926381 agcgtgccgg caataaagtc cggactgcga aggcttcctg tttcatttaa tttccggaat 2926441 cgttcaatgt ggtggaaatc ctttttcgat gaagaacgga tgacggcctg catctcagtg 2926501 tccatcactc caggtgagaa cgaaatcatg ttcaccggca gctcttcatc ctcctgttca 2926561 aatccgaatg tcctcgtaaa catgtcgagc ccggcttttg aactgcaata cgcgctccat 2926621 cccttatatg gatttttggc ggctcctgaa gtaatgttga caaccgtctt tttgccgctg 2926681 tatgaagcaa accgttttgt aaacagctga ctcaaaagca cgggcgcagt caggttcagc 2926741 tgataatggc gctgaagctc gtcaagagac gcttcgccgg cacgtttgat cggcgttacc 2926801 attccggcgt tattaataag ggtaatacca gaataacgat ctgaatcgat ggatgagagc 2926861 aatgtttcaa attgctgttc agcttcttcg agattgatga ggtctatttg atgctgcgtt 2926921 agttttttgt gagagacatc tgttttcgtt ctggataagg catggacttc atgccccttt 2926981 tctaaagcct gtaatgcaat ggcttgaccc agcccttttg acgctccggt gatgatataa 2927041 agttccattg gaaacctcct tttccgttat tattgtacgg cacctctttt acacaacaca 2927101 agcacgcggc ctacgccttc ttgttttcct gcgctgtgac ttttgggatg aggaacacga 2927161 tgcctgcaat tccgagcagg atcagtacga catagatcat cggcagcagc aatgatgatg 2927221 tttcttgttc atcttctgtt tccgttgatg atgtctttgt cattggtttt tcagcaaaag 2927281 taattccaag ctgtttcgac tgggccgcaa tcgtgttgga atcctcggca tttgttgatg 2927341 taaacaaatc ttttatcagc tcggcgtcct tgtccttcgg tttatcaaaa gtgatatcct 2927401 tttgttcctc aggcagttct gttttttctt catagtaggt atcttcatgc aaataattcg 2927461 tatcgatttc gatgtctttt ttctcatact ggtttggcgc gacatctgta ttttcttcag 2927521 tttgggcagc cgctgcagag ggtatgaaaa gggaaaagga gagcatacaa atcatgatcc 2927581 ccttttccat gctgcgatca cgcttcatac gtttcatcgc tttctgctgt gtgttcagcc 2927641 atcaaccgga taatcagcgg cagagccacg gcaatcaccg taatgatcag cagaactgtt 2927701 attcccattg taaacaagtg cccagtaccg tactggatgt cgatatatac tttcgaaacc 2927761 ggatcttcaa atgtaaagtt cggcatgatc aaatcaataa gcggtgcgac atagaatagg 2927821 atcattgctg ctgaagcaac ccagccaggg attgatccga atctgaatgc cgtccggatg 2927881 aaggcagagc ttgcgaccag caatagaatc gtaaacaccg accacttaat cgtctgatcg 2927941 tccggcagtg aataaatatt caagccgaac aagctgatca taagtccgac aaggatattc 2928001 agaattccga ataacgctcc tttgacgaga agcggtgcgt tttggtaata cgagctgaaa 2928061 tagccgatta acagactgct gatcaacaca atgacaagga tgacaaccgg aggtaccgtc 2928121 tgaatttttt cttccggaac ctctccgctg attttaagcg gattcgctaa gtaatcatat 2928181 acatagccat tgttttgccc gtctactaat gtatttccga gtatgccgta tacgtcattt 2928241 cgcacgagtt tcgtggaggc gacatttttc ccccagttgt tgtttaaggt gtcggctttc 2928301 gcttgaacat cattaacgct ttgctgcatg ttggttgtgt aatcaatgat gccggactgg 2928361 cgatcagaca atgaacccat catgtctgac atttgcagca cttcctggcc gaccgtatct 2928421 tggacactca gtgccatggt accagacagc ccatcgttgc tgaacgtcgc agattcctgt 2928481 gttgcgcccg ttacaagctg ttctgacgct tttgcggcac tttcagagat tttcgtcagt 2928541 tcgtcgagaa cacctgcttg agagtcacgg atatagccgc tgtagtcgtc cgcaaatttg 2928601 gtcatgccgt cgatgaagct gttaatatcc tcatctgttt gcatcgtgtt gtttttgaga 2928661 gcttcccagc tggctgattc ttcaggtgtg agagccagga ctgattggac gttgccatct 2928721 tgctcttgga tgacttcacc tttaataata gtcaaagagc ctagatccag attatcattt 2928781 agcgtagact tatataaatt taaagagttg taatacttca tcaagttaga aatattatca 2928841 gtttcaattc tacttgaaaa aattgaactt agtttttctt tctgatctat atagcctcta 2928901 ctctgcaaag tttgtattat ttcgtcttcc aaattgtata ttaacctata agcatcattg 2928961 acattattat caaaatcaac caactttttt gttaagtcac caatttgatc atttaatttt 2929021 gaaactgttt tatttaactc tttaatttct tgatttaact catcaatatg tttctctagt 2929081 ttgttgttat gttcctcttg tttttcttga agtgcatttt ctatttcctc taattttatc 2929141 gctgcttcgt tcagacgttt ttttgcacct gaaatatcag tttcaccgtc agctccgtca 2929201 ccctgtagcc catcactttg atttgagcca tcgttttcat ctgcgagttc aatcaaagag 2929261 aaatctgttt tagaggttcc tgtattctcc gtgtttgtat cttgttcagg aacgtttttt 2929321 gaagattctt gatgtttttg tcccgtttca atgttagttt gaacatcatt ttgtgatcca 2929381 ttatcttgag taccctcttc tgatgagcca gtatcttcat ttgttggctg atcatcggat 2929441 gttggaatat cattcgacgg ttcttcagta ttaggagaat catcggttga tggttcttca 2929501 gcatcgggtg ttgttggttt ttcttgttca ggttctttta acccttcaga gatatcttta 2929561 atttcagttg caacattttt gagctcatcc cgctgcttct ctaaatccaa ttttatatct 2929621 tcaatatctt ccttatctgt gtcatcttta ttatcagatg tgtcttctcc atcttccttt 2929681 tcgtcgcttt ccttaggttt aagtaaacta aggcggttct tcccgatatt ctcttgcaat 2929741 tgatttaaat tttgatattt aatagcttca tattgacttt tatatcgaga tagaaatgca 2929801 ttaaacatgt cattctcaat ttttttcata cccatttctt gcaatggcac ttgattttgc 2929861 cttaactttt cagcattgtt caacgcaagg tttgtcagtc ctatttgtgt cttcgcttgg 2929921 ccgatcccgg ttgccaatcc gctcatgcgt tcgctgaact gattcgcctt ttgctgtgcc 2929981 tggatggcat ccagacctgt ccggatttgc tgctgtgttg aatcctgggc tgccaaaagc 2930041 agctttttct gattctcttg atattctttg tacctttcaa ctgtatcaat gaattctttc 2930101 agcgtgtttt tggcttcctc cgccgtagaa gctttttctt ttgtcgtgcc ttgcgcttca 2930161 ttcattgatt tcttcagctc atcgattaag tctttttgct gtttgatttc acctgctaaa 2930221 tcattagagc ttggtttgta aaagttgtac atgacattct ggaattcaga ttctttattg 2930281 acgatcttgt caaattctcc tctgatgttg tccacttttt gcgaaacaaa attccagtat 2930341 aaggccgaca tttttttgtt cattgtcttt tgggcatcct caagctcacg ctgaactttt 2930401 tctttgttaa ccgcattcag gttatcttga atgctgaatt cgagcgttgc cttttgagga 2930461 tggtctttgt catagctcaa aatgtttttt gagaagtctg agggaatgta gacaatcgca 2930521 tcgtatttct ttgaagcgag accggtctcg gccgcgcttc ggtttacgac cgtccacgaa 2930581 taatcaggac gttcacccag aacggccgct acttccttgc cgaactgggc ggatttgtcc 2930641 tcttcatcag actttacctc atcactcaat acgcctgtgt cttcattcac caccgcgatt 2930701 tgccgggtag aattgactgc ttttttcgtt gggtcgtctc cgataaatcg gaaaaacaac 2930761 accggcagca gcaaaatgat gatgacggcg gatattaact tgatcaagct ttttcgttgt 2930821 tctgtcatct agcactctcc ctttcagcag aacataaagg aatttgaact ttttgctcct 2930881 tcccgttttc cacaacatat ccgaagcccg gctgaatctc aggctcctgt ctttggtacg 2930941 ggagaggaat gacattttgc tcagactttt tcatcagcag aatcgcgtgg cggatttgct 2931001 tcatctcagt cgtcaaggag tcatagcctt ttgagaattc gctgtggttt ccgcccggga 2931061 taaagctgaa cccaagatga gcgtatgatt tcatgaagtt agcgagacga tcttgtattc 2931121 tcgtatcaat cgtctgctgg aatctcgtta tcccgtcaat catcagcacg acttgtgaga 2931181 atcgcagatt ttgtgcgtct ccttggcgga cggcttctac atacatggct tctcttgttt 2931241 tgaaaatgtc ttctgctgtt tcaatccact gctcaatatc ttctttcgtt tccaaatatg 2931301 aaacatctga ttccttcgca taatgagata agccgcggtc aatcgagtca aacaggccga 2931361 tcatttcggt ttcatcatca atcagatgtt caagcatgac ttttaggacg tttgttttcc 2931421 cgcgctgagt ttggcctaaa atcaggcagt gcttatgctt gcccaaatca aaatagactg 2931481 ggctgactgt ttcttcatga agcccgatcg gtacagataa aggcttgcgt tccagcttga 2931541 agcggataga caattctctc gtcgacaagc tctcaggcag catcggaatc ggtgccggct 2931601 gctccattga agcaaatcgc ccttgaagtt tctgtacgtc tgatttcagc tcgttgaaca 2931661 tgccgatatc atcatcggcg tcaacaggca ggaacatttg cgcgaaataa agctcttcct 2931721 tttgaatgat gacgcgtccc ggaatcggct caagattgaa tttcggacgg ccgtaaatgg 2931781 aatatccttc tgattgatcc atgagataat ggacaatctt tgttttcaag ttatttaaca 2931841 atgactggcg gacagcattc acccgcgttg ctgtcagcat aaagtagata cccaagcttt 2931901 gtccgtctct ggaaagctgg acaaattccg attcaagctc atgcatctca tccttgacaa 2931961 tgtcaaagtt gtcaatggtg ataaaaatga atggaagctc ttcttcgctc agcgcattgt 2932021 acattttgat gtggctgatt tctttttccc ggaacaaacg tttacggcgg tcaatttctt 2932081 ctttgatgcg aatcatgaac ttttcaattt tccttgactg gtccatcagg aagtaatccg 2932141 cggtatgcgg gagcttcgct aatggcagca gcgttccgtt tccgaaatca aagatataga 2932201 catgaagctc ttcaggtgtg tatacgtccg caaaactcat caggaacgtt gcggctgcaa 2932261 tcgattttcc gtagcccgaa gagccgaaga tgccgatatt tccatcttcc atcatcttat 2932321 aagcaattgg cgcctgtctt tgcagatcag gttcatcgac atacgcaaag tggaaatggt 2932381 ctttttcgtt tgaagggaaa agagtgcgcg gaatacgttc cgcaagcggc ggcagccaag 2932441 ggcttggcag cttctcgatt cccatttcat cttggatgcg ttcaatttcg tcaactacag 2932501 cttcgatttc ggtttgaacg tcttttttcg cgttatcttc ggtatcaacc tcagaaagcg 2932561 ggatcagacc cgtatctgtg acgatcgcga tttcatcctc ggtaccgtag acttcctcta 2932621 agtaaggcgc cccgctccat gcagattgga acagctcata cacttcattg tttccgacct 2932681 gcaaatagcc gcggcctgtt acggtaatgt ttgcggcatc gctgtttttc aaaatttctt 2932741 tactgtcggt ggcatcctgg accttgagcg ctactttaaa gcgcgagtta ctccagatct 2932801 ggtcgtcgat gatgccgcct ggcttctgtg tcgccaaaat caaatgaacg ccgaggcttc 2932861 gtccgatacg cgcggcactg acaagctccc tgataaaatc aggctcctcg cttttcagct 2932921 cggcaaactc atcagaaatt aagaacaagt gaggcatcgc cacttctgct ttcccttgct 2932981 tgtatagctt tgtatagtca ttgatgtgat tgacttgata ctggtcaaac aggcgctgcc 2933041 ttttttttag ctcgctttta atggaagcaa gcgcacgcat actgaagttt ttgcttcctt 2933101 caatatttgt gatcgtgccg aggaggtggg gaatgttacg gaacggctgc gccattcctc 2933161 cgcctttata gtcaattagt aagaaagccg cttcatgcgg atgaaaatgc actgcaagtg 2933221 acaagatgta ggtctggaga aattcacttt tccctgatcc cgttgtcccc gcaagcaagc 2933281 cgtgcggacc gtgtgctttt tcgtgaaggt tcagatacac aatgtcatct ttccctttat 2933341 agccgatcgg cactgacagc gacttcgacg attcacttgt cagccatctt tgctgaatgc 2933401 cgatttcttt tacttccttc gcatgaaaaa gctccaggaa cgataccgtt tccggaatgg 2933461 aattcgtaat gccgacctgg tggttcagcg tccgcagtgt gcgtgaaaac cgttcgttat 2933521 cctcacgctg atgatgatcg agacggaacg gaattcttac cgcttttttc ttttgtatta 2933581 aaatgtcgcc ttcatgctca ttaatgtagc ggacaagagt tgtaatgttt tccgacaagc 2933641 tttcctttgt ttctgcagcg acaattgtcg agatgcccag atgctcatgc tgcccttcta 2933701 aatattcgag aatgacatgc tcagagatca gctgctgatt cgtgatgaca aatacaaaat 2933761 gcggtttgaa ctgcagtttt tctttgtcat cttcgagatc acgctctctg atcaattcgt 2933821 aaagtgaaga caggagctga tctcgggttt gctcattata aataaatcct tttgcataaa 2933881 tatggggcat ttgaaattgc ggaagccact tcatccactc ccagtcttta tactcttctt 2933941 catgaaaaat aaatacgaaa cgcaaatcgt gatagctgtt aaagaacgac agctgtccga 2934001 ttagctggtg aatctcattt ttcacaattt gtgatttacc gacaagcccc atcggacctt 2934061 ctgccaaatc gaccgtcacc ggcgcattac ggatatcttt atagacgcgt tgcatgtgct 2934121 gcgatttctc catgaggtca tcgatatcac gattcgccaa gtctccgcca ctcatattga 2934181 tttcatagct tgacggaact gttcccgtcc caagccgcag ctggagataa tccttgcttt 2934241 caagtgattt ttcccagatc cggtcactga tttcacttgt taagtatttc atttgttcaa 2934301 atgaaggaaa gtgaaattca agaacctgct tttgcttttc agcaagtgcc tgaagctctt 2934361 tccgcttatt gtctaagtaa agcttatata cacgctcccg tttttcctcg cgttttttcc 2934421 gctggttttt atcacggaaa tattgcactg tcgaggtaat gagagtcatc ataaacatcg 2934481 ccaaagaaac gagtataaat atgccgcgcg gctggatgat ggcaactacg cccatcacga 2934541 tcagcatcac aagcggaggc aggatgacga gccacagccc tctgttggtt tgatcgctct 2934601 cctgagaggg aaaactgaaa gaaacgcggt catccggcag atcgtatacc atccgcggcg 2934661 ttcttctgta ctgcggatat tttttctgca tctctgtact cggtttgacc gtttctgtta 2934721 acgctgtttc aaactgggca taatgaacaa tttctaaaag gtcttgttcc gtcaccctca 2934781 tttgcgtgaa gttccagaat atttcatccc ccggcttgag cggcgtattg gcgttgattt 2934841 tctctccgtt caagaagatc gttccgcttt cagggcggac cgaccagctg ccgcctgcac 2934901 ggagcaaaga aaacgtgctt tgttctgcaa atgcaaaatc ttgcggattc agataaatat 2934961 ctgcattcgt tttttctgag gaacatacaa tttcatcccg atttcccgta aaataaacgg 2935021 atttctcagg ttcactgccc gtcaatatca agcgtatatc ctgctgatcc gtttggagag 2935081 taaatgatat atccgtctca atcgtgccga gacaatcatt tcccaggaaa acttcgtatt 2935141 ggccgccgga ttcctttctt ttaagagaaa tcactccgct attaaatgga atggtgctga 2935201 tcgtaacaga atccttcaca tcaggcccta tggtcaccgg atgagacgac gggaggttag 2935261 acagatttaa tttttgaacg ttattttggt aaaaaaccca taatagactc aaatggcgaa 2935321 cccccttacg gccgaatggc agcatgcgat gacctgcgct tcatgtctca cgttatttgt 2935381 catctttttt ctcatctttc ttttctgttt cttttttctc gtcttctttt tccttctgtt 2935441 cttctttttt cgctttttcc tcggctgcgg ctttttcttc tgccgctttc tcttctgctt 2935501 gtttttcttc gtctgtttgt gtctgttctt cgcttgtatc gactaacgat gtttcagaat 2935561 tagactgttt attttcttga cgttcttttt gggctttttc aagctcacta tttactgaat 2935621 caagttcttt ttgtatgtct tcatcatttg tatcctcaga taaaagctgc tgtttatatt 2935681 tagctagggc aaagtaaata taatcattgt attccagctt acggccgata ctgatcgctt 2935741 ctttgtattc tcctcgacca taatcaatcc aatataagaa atgctgaggg tctgattgaa 2935801 gggtgactaa attattttct atatttttgg tttttgcact ccccaggttt tcgacctcaa 2935861 cataggacgt cgccagctga tactgcaccg attcaggcag gctttccgca tcgtacttgg 2935921 acagtgtgct gatgacttca ctgtactgct tgtttaagaa cgcacggttg ctgtccacta 2935981 tcgcctggtg ctttggctgc gcgaaaaata aggcgtacat cgaataaata agtgccggta 2936041 caagcaaaac aatgagcccc aggccgatat atcgctggat gttccacttc tttctcggga 2936101 tatgtatgta tgtttttgct ttggcttcga gctcatcaat atgggtttga atcagctcga 2936161 gcaaatcatc ataggattca gcatctaata tcgcctttgc ctctgcggag aacgtcagcg 2936221 tttcattgaa tttcaggtag tcttcaaacg caaaagcgcc gtcaactgcc aaagccgctg 2936281 ccgctttcag ctcctgccat actctttcct catcacgctc gtaaggagga atgctttctt 2936341 ttactccata atggagaaaa taaggcgtaa gccctttatc gaatacaatg ttttcaggag 2936401 cgacaatcaa attcagcctc gacagattgt gctgctgtac ggcttgaaca agctgatagg 2936461 caaactgcca tttacttttt ttatccttag ctttcatgaa gcggaatgct ttataggagg 2936521 agggaggttg gattgtgatg attacttcat catccgtcac atcgatttct ttatgaaaaa 2936581 atggatttat atctttgatc acgttagctt caagaccgtc gagaagcttt attttttccc 2936641 gttgaaaggt aaatgtatag ccggcatctg ttttctcggc aacagcttct aattggtttt 2936701 ctaaatatga tttttgttca cctgacattc aaccagatcc tttcataata tttcaagccg 2936761 gtctccgttt gtaatgccgc aatcagacag cttgcattct ccggaaaaca ccttatcctt 2936821 gttcaccact ctgatccagt gcccttcgcg cggaggcata gatacgcttt gggcctgcca 2936881 agcaatatca attacttttt tcaccgggtg gtaatctgac aatctgagat caaagacact 2936941 gccgttataa tgtttcaaat ctattgtaat atcaatatac atttaggatc acccttacat 2937001 agaaagagcg ccgtcttctt ttgaatcagg cgctccttcc ctttcatact gttatccgcg 2937061 gatttgattt gcgatgtctt ggtcagtaga ctcaagtgta tttgctgttt gatcaagctg 2937121 ctgattcaca tcttgaagca aatctgacat tttgataaat gaaggtttga gctgctcgta 2937181 ttgatctgcg aacgcttcgc ttgaagcacc ttcccacatg cttttcaaat cagagatcat 2937241 tcggtttaaa cgatcaacct gatttaatac ttcttggctt tcaacgccgt attgcttcgc 2937301 catcgctctt agctcttcgg gtgtgacacg aattaatcct gccatattcc tcattacctc 2937361 ctgtgccatc agcctaaata tgggctaatt cacttatttt tagaacgtca ttattataaa 2937421 aacagttttt cggcatagtc aaacaaatat gttttaattt tacaaaatga gtccaatggt 2937481 ttaccccgaa tcactcaaaa atgacatata ctgtaaagta aataggttta ttttcttaat 2937541 cttctcttca ttctccgaat aatccaaaag acccaaataa ctctccaact cccaaaaaaa 2937601 acctttcaga aaatttgatg ctacagcacc atttctgaaa ggttcagttt tttctttcct 2937661 taattagtct tgcctccgat gactttctta gaagattaat aggataagct gtcgtattat 2937721 atgagacata cactgtcctg caaaaaggcg attacaccgc caaatgtata tagaacgttt 2937781 ctctcatgaa attgtttttt tgcttctgtt ctttgttgtt gattttcaca aacaacaaca 2937841 atcataataa aaggaagggg atgagatgtc aaagagaaat caagcacgaa aagtagggag 2937901 atttatgacc atgccgaatg atccgtttaa atatagtttt gacagacttg aagatgtggc 2937961 tgatcatatc agcgacgttc tgcggtgccc gatcaccata gaggatgtta accacaagct 2938021 gcttgcctac agtacacaca gcgactgcac agaccctgcc cggacgtcta ccattattgg 2938081 cagaagggta ccggagaagg tgattaacaa gctgtggaaa gacgggacaa ttcctgctct 2938141 cttaaaaacg gaccagccga tcagagtcaa gcaaatcgat gaagtcgggc tgagcaatcg 2938201 cgtcgctatt tcgatttgga aaaacaagca agtacttggc ttcatatggg cgcttgagat 2938261 ccaaaaaaca ttgtccgatg aagatctgct gacattgcaa atggcagcaa aagcagtgaa 2938321 aaacaagctt ctcaaacttc aaatcagaaa aacgaaaaat gaagaacgca gccaagaatt 2938381 tttctggaaa atgctgaccg gacacatcca tcaggaggat gatatggcgg atgggttcca 2938441 taagcttgga atggccgctc cttcagagtt ttccgttatg atcatccgca taaatggcga 2938501 gctgactgaa aaaatcgaac agcagctgca atatttacag gaaacgaccc agcaggttta 2938561 cgtgctgctg gcgaccgtag attccaatga acttattata ttaacctcac ccaaaacaga 2938621 tcatcctttt caagatttaa aacagtttgc tttaagtacg caaaaacagc tgaaggagcg 2938681 gtataaaata gaagacgttt ctatcgcttt tggcggaata tacaactcta tttcttttgt 2938741 ctcccgctcc tatcaggaag cattgtccgt cttaaaaacg aaggaacggt tcgctgaaga 2938801 gaccaaacat cttttcagct tttctgagtt aggcatttat caatacttag atgtcttaaa 2938861 tgaaaaacgg aaacaggcgg gccattataa ttactcgctt tccaaactgg aacaatatga 2938921 ccgggatcac cagtcaaata tggtagagac gctagagcgc tttattgaag cggacagcaa 2938981 cgtgaatacc gcttccaagc tgttaaatat acacgttaat acgttgaatt accgactcaa 2939041 gcggatcagc cagatcgctg aaattgattt gaaaaatgtg aatcaaaaat tcaccatcta 2939101 tttagatatc aaacttcggc acatggattt gtgaaatttc acaaatccat gtttttttat 2939161 tttcttaatc aaacaaagaa ttttccaaaa tatcaagcta cactaaaaat atcacatata 2939221 caggaggaga cagatatgat cataggggtt cctaaagaga taaaaaacaa tgaaaaccgt 2939281 gtcgcattaa cacccggggg cgtttctcag ctcatttcaa acggccaccg ggtgctggtt 2939341 gaaacaggcg cgggccttgg aagcggattt gaaaatgaag cctatgagtc agcaggagcg 2939401 gaaatcattg ctgatccgaa gcaggtctgg gacgccgaaa tggtcatgaa agtaaaagaa 2939461 ccgctgccgg aagaatatgt ttattttcgc aaaggacttg tgctgtttac gtaccttcat 2939521 ttagcagctg agcctgagct tgcacaggcc ttgaaggata aaggagtaac tgccatcgca 2939581 tatgaaacgg tcagtgaagg ccggacattg cctcttctga cgccaatgtc agaggttgcg 2939641 ggcagaatgg cagcgcaaat cggcgctcaa ttcttagaaa agcctaaagg cggaaaaggc 2939701 attctgcttg ccggggtgcc tggcgtttcc cgcggaaaag taacaattat cggaggaggc 2939761 gttgtcggga caaacgcggc gaaaatggct gtcggcctcg gtgcagatgt gacgatcatt 2939821 gacttaaacg cagaccgctt gcgccagctt gatgacatct tcggccatca gattaaaacg 2939881 ttaatttcta atccggtcaa tattgctgat gctgtggcgg aagcggatct cctcatttgc 2939941 gcggtattaa ttccgggtgc taaagctccg actcttgtca ctgaggaaat ggtaaaacaa 2940001 atgaaacccg gttcagttat tgttgatgta gcgatcgacc aaggcggcat cgtcgaaact 2940061 gtcgaccata tcacaacaca tgatcagcca acatatgaaa aacacggggt tgtgcattat 2940121 gctgtagcga acatgccagg cgcagtccct cgtacatcaa caatcgccct gactaacgtt 2940181 actgttccat acgcgctgca aatcgcgaac aaaggggcag taaaagcgct cgcagacaat 2940241 acggcactga gagcgggttt aaacaccgca aacggacacg tgacctatga agctgtagca 2940301 agagatctag gctatgagta tgttcctgcc gagaaagctt tacaggatga atcatctgtg 2940361 gcgggtgctt aattcacaat aagcttgcag aaagatttct gcaggctttt ttatttttta 2940421 aaaggaaaaa agagaccatt tcacgaatta tgactatgaa gttgatcata aaggaggatt 2940481 catatggctg ttcagcaata tggcgtgtta aaaggcatag tattagacat gaagcgggaa 2940541 acagatgatg acagtcctca tttccaagtc aaaatgctcg gtgaagagaa tacgtattac 2940601 aggtgcgcca tcaatgtgat gtccagttct gaggaatctg aagtattgta tttggctgac 2940661 gatcagtttg attcgggctc aattaccatc cttccgaaca tgccgtatgg atatacaagg 2940721 atcaatgaag caaaccgtga agtggcactg gattatgtgc ggggcaattt gtttgacccg 2940781 cgggaaatga agcctttgcc tcatgaaatc acgggacctg ataatgattt aaatgatttt 2940841 attgaaacct atatgaagaa agcacaagat gagaaaacgc cggtttatat attcggttca 2940901 aaattcggcc ctgaacaggc tgcagataaa atattcggct ttaccccgac taacggaatg 2940961 cacaatatcc atatgaatca agggaatgca atggataccc gctggaaaaa agacaacggc 2941021 tcttggcatg acgggggtat tctgattcag tttgcagatc agtgggccgc tgtgttttta 2941081 gcgtttttat cccaatcttg gtgtaccgat gaaaacggaa accctgtcag agattgtgat 2941141 catacccaaa cgtctgcgta agatagaaaa agagactgcg gcaagcagtc tctttttgat 2941201 aagattacac attttcaaca gtctttaggc tgtttggcct catatcgctc caatgcgatt 2941261 ggatatagtc caaacaagct tcacgccctt tttgctcatg aacgactgtc cagccgctcg 2941321 gcacatctat aaaacccggc catagggaat attggccttc ttcattgacc agcaccaaat 2941381 atgtgccatc cgcattttca aaaggatttg ccattctatt tctcctccct tatttattca 2941441 actcttccaa tttgacagcg agaaccttgc cgatttgagc cagaggttca ggctgacata 2941501 aatctttatg acggcagtcg atgtcgattt gttcaatctg tccgttaata taaggcttcc 2941561 acgagtcagg ttcaatcggg tcaaaccatt caggaatgat tgttgatctg aaaaacaaaa 2941621 catttccgcg gaaggttttc ggcttatagg aacctaaaat gccgacagaa tttacatacg 2941681 tattcttcaa atttaaaatg accgtttcat ccaggctcgc aagcgcactg ccgtcacggc 2941741 gaagaatctc aatcgccgct tcaaaatcta gcggtttttc ccctaagctg tctggatcat 2941801 acccgcctaa cgccagaagg gcaataagcg cttcctcatc atccggtgcc tcttttatag 2941861 gaaggaagtg gttcggatag gcgtccagca tcaccaacag ggatacttct tctccttgat 2941921 tttgcagctg ggtagccatc gcttgaacga cattcccgcc cagggaccag cccagcagat 2941981 ggtacgggcc ttttggctgg accgttcgga tttgtttaat gtaatcggca gccatgtcat 2942041 caagtgtttt cggaagctcc tcgcgctgcc cgattccccg tgcctgcaag ccgtagatcg 2942101 gataatctgt tcctatattg gtcatcaaac cggcataaca ccagctgagc ccccctgccg 2942161 gatgaacaca gaataaagga ggcttgtctc cgcttgttcg gagcggcagc agaacgtcaa 2942221 gagcgctttg gcttgatccc atttcaagtc tttcagcgag cccggctaca gtaggtgctt 2942281 cgaacaagtt gccgatgctg agttcaacgc cgagcgcttc acgaatgcgg ctcatgagct 2942341 gtacagcaag caaggaatgt ccgcctaaat caaagaaacg gtcatcaatg ccgacacgcg 2942401 gcaagtgaag cacctccata aagaggtcac agagaatttc ttcctgcggc gttctcggtc 2942461 ctcgtcctgt cactgccgct gcgaaatccg gagcgggcag cgctttacga tcaagctttc 2942521 cattcggtgt cagcggcaat tctttcatcg tcacaaaggc agcaggcacc atgtaatccg 2942581 gcagtctctc agcagcatat ctgcgcagtt ccgccgtatc aaatgtttct tccgaaggga 2942641 tgacataagc tgctaaccgt ttatctcccg gctgatcctc acgaacgatc actgccgcat 2942701 cttcaagctg cggatgctga acaagcgcgg cttcaatttc tcccaattca atccggaatc 2942761 cccgaatttt cacttgatgg tctgcacggc cgacatagtc gagagaaccg tcagcgcgga 2942821 ggcgggccac atccccagtg cggtacatcc gggtgcctgg aggaccgaac ggatcagcta 2942881 tgaagcgttc agatgttaaa ccaggccggc ctagataacc tcgtgctaac cccgctcctg 2942941 atacatacag ctctccggca acacccggcg ggaccggctg caggcgttca tccagcacgt 2943001 atacaccaag atcgggaatg ccgcagccga tcaagctgtt tgcccgtaaa gctgccatgc 2943061 ttcggtctaa ttcgatatag ctcacatgca ccgtcgtttc tgtaatacca tacatattga 2943121 taagctgcgg tctattttca gggtggcggt tgtaccaatc ctctaaacgg ctgagttcaa 2943181 gcgcttctcc gccaaaaatg acatagcgca gactgagtgc ctgtccgaga tccggctgtt 2943241 cccgttccgc ctgcataaac tgatagaaag cagacggtgt ctggttcaga acagtcaccc 2943301 cctctttgac aagcaggcgc agaaacgctt ctggcgatct gctgacgtgg tgaggcacga 2943361 ttacaagacg tccgccatgc agcagaggac cccagatctc ccacaccgaa aaatcaaacg 2943421 cataggaatg gaacatggtc cagatatcac ctgagctgaa acggaaccag tgctcggtcg 2943481 ctgcaaataa acgtgttaca ttttggtgag gaatcatcac accttttgga acacctgttg 2943541 agccggatgt ataaatgaca tatgccgtat tcaaagggga aagcggctga gtcctatcct 2943601 tattttttgg attacctgca gggtacgtgt ttagtttctc tgccagctcg ggatcatcca 2943661 gcacgatttt cggcacgttt tcaactggcg gaatgtgatt tgcagcttta gtgttcgtca 2943721 tgataaacgc aggctgtgca tcttttagca taaaagcaat tcgatcagcc ggataatccg 2943781 gatcaagagg gagataagct gccccggcct ttagcaccgc caataggccg acagccattt 2943841 ccaacgatcg gggcagtgcc aatgccacaa attgctccgg cccgacacct tcactaatca 2943901 tcattcgggc aagccggttt gctctttcat tcagctctgc atagctcagt tcctgatttt 2943961 catatacaac ggcaatggca tcaggacgta aagcagcctg cttctcaaat tgctctggca 2944021 aacatgcgtg cggaatcttt tcagatacac tttgccaatc agtcaccatg ctgctgtgtt 2944081 cctctggcgc aagaatatcc agatttccga tttgctcgtc aggatcagac tcggcagcct 2944141 ccaacaggcg catcaatcgg tcagcaagag cctgagcagt ttcccgtttg aaaagatcag 2944201 tgctgtattc aagcagtcct tccattccgt ttggtgtccc gtcagcaagg cgatcttcac 2944261 taatttccag cgtcaaatca aacttggcag aaccgacact gttgattcgc aggctgctct 2944321 ccatatcagg aagatgcagt tcagcgtccg gtgtgttttg gaacgcaagc atgatttgga 2944381 ataaaggatg cgtcgcacgc gaacgagccg gattgagcac ctctacaagt ctctcaaacg 2944441 gcagatcctg attgtcatag gcggccagat tcacttcccg tactctgtct agaagctcac 2944501 gaaagcttgg gtcaccggac gtatcagttc tgagcaccaa tgtattaatg aacagcccta 2944561 caagatcgcc cagcgcatca tcattccgtc ccgcgatcgg actgccgatc ggaatgtcgg 2944621 tgcccgcccc gagccttgtc aataaagcgg cgagaccgga ttgaagcacc ataaacaggc 2944681 tcaccctatt tgcgcgagcc agctcctgca atcgcttgtg aaactcgggc tcaatacgaa 2944741 aatgaatcgt atctccatca tgactcggct cagccggacg tgaataatcg gttggcagtt 2944801 caagctgatc aggcaggttt ttcaaggttt ctttccagaa agcaagctgt ccggcaatca 2944861 agctatttgg atcatcctcg tttccaagca gttcttgctg ccaaagcgca tagtctgcat 2944921 actgcacagc aagaggcgcc cattcgggag atcgtccgtg gcagcgagcc gcataagctg 2944981 tcccaaggtc tctggtcagc ggtgttaagg accagccgtc cccgacaata tgatggacga 2945041 gaagaagcag cacgtactcg tcaggaccga tcacaaaaag ctcggcacga aaagcaggtt 2945101 cagctgcaag atcaaagctg tagcgtacag cttcggcaag ccgatcagaa agctccttct 2945161 cagcaatttc agtaacatgt aactcgggac aggctcgatc ggcatctaaa atatgctgat 2945221 aggatgtccc ctgtgattca gggaagatcg tccgaagact ttcatgacgg cagacgaggt 2945281 cataaagtgc cgctttcagc aatccttgat ccaactcacc tgacaaacgg acagcaaccg 2945341 gaatattata agtaggactc ggtccttcca gacaatgcag gaaccatagc cggcgctggg 2945401 caaatgagag cgggatcttt tcaggccgct cagctctctg caaagcggga catgcactct 2945461 gcgccaaatc aagatgggca gcgagtccgg ctactgtcgg ttcgtcaaag agcttggcga 2945521 taccaagttc ggctcccatt acctcgcgaa tgcggctcat cagacgggct gcaagaagag 2945581 aatggccccc aagctcgaag aaactgtcat cgataccgac gcgtgccaaa ccgagaacct 2945641 ctgcaaacaa gtcacacaat atctcttcct gaggagtccg cggggcccga tcactgacag 2945701 atgtgctgaa gtctggtgcc ggcagtgctt tccggtcaag cttgccatta ggtgttaacg 2945761 gcagctcgtc catctccaca aacgccgacg gtaccatata atcaggaaga ctagccccca 2945821 tataacgacg aagctctgca gtatcaatag cagcatcagc gactacataa gccgccaatc 2945881 gtttgtctcc cggctgatct tcccgtacga caaccgcggc ctgttcaatg tgcgggtgat 2945941 tggcaagcac ggcatcaatt tctccaagtt caattcggaa tccgcgaatt ttgatttgat 2946001 gatccgcccg cccgatataa tccaaagacc catcggcgcg ccagcgggcc tggtctccgg 2946061 tccgatacat ccgagttccc ggcggtccgt atggatctgc aacgaagcgc tccgccgtta 2946121 aatcaggacg atggaaataa cctctggcca agccggttcc tgcaatataa agctctccga 2946181 caacgcccgg cggcaccggc tgcaatccat tatcaagcac atacacctgc gtgttccaaa 2946241 tcggtttccc aatcggagga acgcccttca gcccttcttc aagaaaagct gcggcagacc 2946301 aaatcgttgt ttcagtggga ccgtataagt tcgtgactga acaatgaagg tcttgaagtt 2946361 cctgcaaaag accgctcggc agcgcctcgc ctcctacaag cactctaagc ccccgaagtt 2946421 tctcaggttc actcgttacc aaagcgtgcc acagtgtcgg tgtcgcctgc ataatgttaa 2946481 tatcgaaatt ttcaatcatt tgagctaatg cctgcggctc acggatcgtt tctttctttg 2946541 cgatcacgat ttgcgctccg ctaatcagcg gaagatataa ctccaatgct gaaatatcaa 2946601 aagcgacagt cgtcacagcc aacagcctgt cttcttctcc tagagaaaat gcctcctgca 2946661 tagacagcag aaaattgctt aagcttttct gtgtcacaac gactcccttc ggtcttcctg 2946721 ttgatcctga ggtatagatg atatacgcag gatggtcaag cgaaaccgat acatcctgat 2946781 tttccggcga atagcgtttt ataatctcct gtgtaacagc ctgatcaagc acaagctcag 2946841 gtacagccag gtcatcaggc agactggctg ctatttcctc agtcgttatg atgcatgaag 2946901 gtttcgcatc ctccagcatg taagaaatgc ggtcggctgg aaactccgga tcaaggggga 2946961 gatacgccgc accagtcttg agcacaccaa gcattgaagc caccatctca ggggaacgcg 2947021 gcagcgccaa agcgacaaat tgctccggac caatcccttt ttcgatcaac agacgcgcga 2947081 ggcggtttgc ctcttcattg agctttcgat agttgacttg aatgtcatca cacatgagag 2947141 cgatacgttc tggcgtaaga actgcctgct tttcgaacat gtcctgaagg ctgaccagct 2947201 tctcggattt tgccgtctca ttccatttag aaatgacttt ttctttctcc tctggcaaca 2947261 gaagctccat ttgcccaatc agcatgtcct ctccggcaga agccgtttgc agcagctgca 2947321 aaatacgctg ctgatgaagc ttaatatcag actcactgta tacctcggga ttcgcatcaa 2947381 catcaattcg cagcccgctg ccgtctgttc tgtcatatac attgattgat agatcatcaa 2947441 caggaccggc tgaaagatta tgcgttgtgc cccggacgcc ggcaaagtcg agaccgtaat 2947501 caaacggcat aagattgatt tgagggccaa ataatctatg attttctcct atcaatttca 2947561 gatcgcgcct aagctcttca tggcgatact tatgatgtcg ccgaatactg cggatttccc 2947621 gggaaatttg ctgaatcagt tcagaaaagc tcatcgaaga gcttaccgtc agccggagcg 2947681 ggagaaggtt catcaccata gccggtacat tcagtgacgc ggaccctatc cgacccatca 2947741 tgggcaggcc gagcacaaca tcctcagagc cggtcatacg gtgcacataa acagctgaca 2947801 ccgcaatcat gacttcatgc cagcttcctg agaaatagcg cgccgcttct tttaacgcgt 2947861 ttacatcaga cggaggcaga tatgccgtat gacgaagaaa actgttagat gttcttggcg 2947921 cccgatcagc caagctcaca acttcaggtg catctgcaaa acggtccagc cagaattgac 2947981 gatccttctc atactgctct gatccgcgat aatctgtatc ctcctccaaa atggcctgga 2948041 gagacccaaa ggaacggctt ttagctgttt gtccttttat aagggcagta tatgtacttg 2948101 ccacacgctg ggctatcagg gaaaaaccga agccgtcgat cgctatatgg tgaatgcgct 2948161 gataccaaaa gaaacgatca ggcccggcaa taaacagagc ttcattgaac aaaggggcat 2948221 accctaaatc aaccggcttt gctaaatcag ctttcatcca gtttaatgct gttttttccg 2948281 gatcaggctc agagctgacg tcaatgacgt gcagctgtac atccggagac gggtttatca 2948341 tctgccaagg cccgtccata ttttcaccga agcggacatg cagcgattcc gcttccttga 2948401 tcacgtgccg caaagcttct tcaaaaagag caatattgac tggtccattg atttctatat 2948461 attccgctgt attgtagatt ggattgtccg gatcaagctg ctgagcaaac catatgccag 2948521 tttgcgcccc ggtcaaagaa tattgaagat cttttgtatc aggcatccgt ttgtttaccc 2948581 tccttttata aataatccgc gtttggcagc acttgctggc tgcgagttgt gagcaatttc 2948641 tgccattctt cgatcgttgg gcgttcagcc aattccacga aagtcacctc tgccccttca 2948701 cggcgccatt gttccaccaa tgtcatgatc cttaccgaat caagaccacg atcgagcaaa 2948761 tcctcttgat ctgtgatgtc ttccggtgtt tcttgtagaa gctcagcaat ttgtttacgg 2948821 atattctcac atgtaaacac gttctttttg ccagtgtttg ctgacgtttt ttgaacgtct 2948881 gccggcgcat tctgcagctg atcaagaaga ctgtcagtca tcacggtaaa cgcacagcgt 2948941 ccagccgcat attccagcgc catttgatgt ttttctaatg aaaaatcagc aactgcatct 2949001 cccacaaaaa aggctttaat atcctccata aatgcttcac atgctgtaac aagacagccg 2949061 atatgggcgt aaattcctgt aatgatcagc tgatcgcgtc cctctttgcg catcatttca 2949121 agcagattcg ttctcttaaa cgcgctgtat ctccattttg tcagcacaag atcatcatcc 2949181 tctggtgcca gctcggttat aattttctcc tcataaggac cgctgtttaa tcccgggccc 2949241 caaaagtctg tcagcagcgc acggtcatcc ggattttggc ttcccggctg tgcggtatag 2949301 acaacaggaa tcccaagctg aacacattga ttcttcagct ttcgtatatt cgctgaaagc 2949361 tctgttaccg gagacgctcc cgctgtgaaa gcatcaacaa aatagttttg catatcgtgt 2949421 attaacaaga cagcccgatt cggatcaggc acccatgata ctttgttttg cggcatatca 2949481 gatgctgtcg gcatttgata cggctgaatg gcaggtatag ccatatgaac acttcctctc 2949541 aaattgttgt tttatttttt aaatcctgca agaagcttct cggaaatggc ttcacggagc 2949601 gcttttttgc tgacttttcc tactcctgtc tgcgggaagg attcgacaaa ttcaactcga 2949661 tcagggattt tatatgccgc cagtccgcgc tctctcaaaa atgctttaag ctctgcggct 2949721 tttggggctt catcccgggg aataatgaac acacaagatc tttcgccaag aaattgatca 2949781 ggcatggaga ccattgccgc atcatggaca gccggatgcg ccagcagatg attttctacc 2949841 tcttcagccg caaccttttc tcctccacgg ttaatttgat ccttcgcccg gccttcaacg 2949901 acaatatagc cgtctcgtgt cagcctgacg atatcacccg tacggtaaaa accgtcctca 2949961 gtaaatgaag cggcgttatg ctcttctgcc ttatagtaac ctcgaattgt atacggcccc 2950021 cgcgtcagca gatggcctgt ttcaccaggt tttacgtcgc gatcatgatc atcccaaaca 2950081 cgcatttcat catatggaga catcggtttt ccttgggtgt tgacaatgat ctcctcagga 2950141 tcatccaatc tcgtataatt gacgagaccc tctgccattc cgaacacctg ctgcagcgtg 2950201 cagccgaaaa cagcttttac cctgcgcgcg gcttcagcac taaacttggc accgccgacc 2950261 tgcagcactt gaaggctgga taaatcatca cggcgtgagg atgccgcatc catccatacc 2950321 atcgcaagag gcggaacaag agcggttatc gtgacctttt cccgttcaat taaaggaaat 2950381 gcgtcatctg gacttggaga aggagataat accactcttc ctccagcgta taatacgccg 2950441 agaacgccgg gtgagctcag cggataattg tgtgccatcg gcagcgcggc caagtacacc 2950501 gtgctgtggt cgagccagca gacctccaca ctccgcttca ggctgtatat gtagtcatcg 2950561 tgggtcctcg gaatcagttt cgatagcccg gtgctcccgc cagaaagctg gaggaacgcc 2950621 acatccgatg atttgacttc aggcagtttt acaggttctg catgcaaatc ctccagcggt 2950681 aaaaattcct ctgcctcacc tgcgacaatg atgtttttca aagtcggcag cttgctttga 2950741 acctgtctgg caagcgaacg gtagtcaaaa ccggaataag cgtcgggaat gatatatgca 2950801 gccgcttcag caaactcgca aaaatatgta atttcactgc ttcgatgaga aggcagtgcg 2950861 aagactggaa gcgcccccag acggaaaagc gcgaaaatga cttcaaaaaa ctctttgata 2950921 tttggcaact gcaccacaac acgatccatc tgttgaatgc cgagcttttg aaatccggca 2950981 gccaggcgat cagcccttgt gtcaagctct cgatagctcc aatgggtgtt tccgcatgta 2951041 atggcaatgc gatcaccata tttggctgcc cggtccctta acaaatctcc aaacgtctca 2951101 ccggcccagc agccgttctt tcgataggtc tcagctaact catcaggcca aggcgtaaat 2951161 cctttcagca tgttgtatcc ctccagcaat tcattctgtt catatgtgat ccacgcccat 2951221 tgcccgcagc attgtccgaa actttgcgga cgtctcctga agctcgtcct caggctttga 2951281 accggccaca acaccagctc cagcatacag gcggagtgag cgttcttctg cttctgcaca 2951341 acggatggtc acgatccatt ctccgtcacc ggcatcgtca caccatccga ccatgccggt 2951401 aaagaaaccg cggtcaaatg gttcaatgct gagaatcgct tctcttgcaa gatcagtcgg 2951461 tgttccgcag acggctggcg tcgggtggag cgccgccgcc aattcaagtg cggttacaga 2951521 cgggtcggaa agctctccct taatcacgct ggacaggtgc cacatcgttt ccgttttgat 2951581 cagtgaaggc ttctccggaa cctccagcgt ccggcagaaa ggtctcagcg ctgccgcaac 2951641 cgcgtcagcg acaaccgcgt gctcatgaag atcctttgcg gaagaaagca attcagctgc 2951701 ccggcgctgg tcttcaacag gatcattact gcgcggtctt gagccggcta atgggttgga 2951761 aacgacctgt gttcccatcc ttgaaacgag aagctccgga cttgctccga gcaatgttct 2951821 gcggggagac gtttcctcct gactggacac gtctgcggca aacgtgtagc catgcgagtt 2951881 atgctgagcc agatggcgaa gcaattcatc cgtctgaatc ggttcaggcg atgtcaaatg 2951941 cagcgatctg gacaggacga ttttgctgag tgttccatcg gcaatgcgtg ccagcccttg 2952001 ttcaacacca tttttataat cctcaggttc aggaacaggc tttatgtggt atgtatgccc 2952061 agcctgctgt tccttttcct catgatcaaa ttgaagcggt cctgaccagc gcacttcttc 2952121 aggtacaacg agccgcgctg cttttacttg atcaaaagga acggccccga caacaagcgg 2952181 ccggctttgc cctgattgtt ttgcctgacg taacgcctct gcaattcggc cagaaagggt 2952241 ttccatttgg ttttgcccgt ctgcctccgg tacaatttca catatgcctt tcgctaacag 2952301 tacacgatga ggagacgcta agaaaaaggc gcccggctga tattcatgaa gcaaatgctc 2952361 cgcttttgtt tctgttataa cgttttgatc caacattctc atgaacctcc tttaaattca 2952421 gttacacgcc taaggtcgcg ccgccatcta cgcataaatt atgcatcgta atatgccctg 2952481 cctggccaga aaccaaaaag agcaccgcat ccgcaatatc cgaaggcttg gctagttttt 2952541 tgagcgggat ccctgtttta aatgtctcaa gtgatccttt tatgacttgc tccgctccat 2952601 tctcgtcggc ccataatgac cactgcatgt ctgtttccgt tgatccggga gatacaatgt 2952661 tgcagcgaat attgtattct gcaagctcaa ggccaaggca tttcgtaaac atcacagccg 2952721 cagcctttga agacgcatat gccgccatag atgttcttgg tacaccggca gcattcgatc 2952781 cgactgttac aatcgaaccc gatcttcggt ccatcatata tttgctgact gaacgcgagg 2952841 cgttaaatac gccagtcgaa ttcactgaga acgtcgcctc ccattcctca tcgctaagcg 2952901 aatggatcag tcccgggcga aggacacccg ctacattcac taaaatatca atcggcccca 2952961 tttcacgttc gatgcgcgcc gtgatctcgt caatcgccgc gctgtctctc acatccgcag 2953021 gaaaagcttc tgcatggcgg ccttctgctt tgaggctgct cacaaccttt tccagctttt 2953081 caggattata atcaactgcc gcaatatgtg cgccttgact ggcaagcgtc cgcgcaacag 2953141 cttcgcctat tccttgggca gcccctgtta taaaagcaat ttttccctct ataccctttg 2953201 cattcatatc atcaattcct ttcttcgctc taaatgccaa acagacatcc agcgaaaaag 2953261 actgctgcgc cttgaaaaac gcaatctatt gataatgatt atcattatca attataaaaa 2953321 taatcatatc caaatgtcat gtgacagtca aatataattt cagtgacaaa tattttttta 2953381 aaggcaaggc tgagtatgtc tcagcccatt gatagatgcg gtccgtcagg gtgaagcgca 2953441 aaacgcagcg ccctgctgac caaaacagga agaactgaaa tatgtccttc tcctgaaaac 2953501 tcgcaaaatt ctgcccgtat accttgttca gataaaacgg ccagccgctc ataaagctcc 2953561 cttgcattat cattcatccg gcttttatga tgctgctcta attctcctgc ggcaagcagg 2953621 atattgatag gctgattgtt tttcttggtg agagagacga aatggtccgt tttcttgaga 2953681 ataaacggtt tattccaatg aatggacgga cttcccgcga tatacgtttg aaacgcatcg 2953741 ggctttgtta gcagcacctg cagcacgaaa agccctccga gcgaatggcc aaagattgtt 2953801 tgtctttttt tatcaatctg gtaatctcgt tctatctccg gttttaaatc ctcttcaata 2953861 aatctgaaaa agccctccgc tccgccatgc tccggccatt ctctgccgtc gggcctttcc 2953921 ggcagcttcg attgggctgt tggcattgta aaatcccggt ggcgtgctga ggagaacggc 2953981 tccgctgtct catagccaat gccgacgatc actgcaggga tcaccccggt tttttcgggt 2954041 cggcgtccct gtattcgaac ggcttccgtc atcgttccga agacagaatt ggcatccagc 2954101 agataaatca caggataacc agcgggtggc ggcggcgtac taggtttcga gataaaaatg 2954161 tgataggtac ggttttcatt gcgtgaagac atcatacgca cttccgtacc aggaatcgta 2954221 aatgcgtttg atgtcccgcc atttgtccgg tctgttgttt gttctttcat gcagtacgac 2954281 attcctctcc ttaaactaaa ccgcaatgta tgataatgat tttcactatc aactagacac 2954341 ctcaaataat aggttttctt ccaaagaaag tcaacttttt cccgaataaa aaaggcacct 2954401 tgatcaaata aggtacctgc agactatcaa tatggaagta aaaacctaat aaagatgcgt 2954461 attgtcctat ttgaaataga accttaatcc catgtaaacc tttgattttg ccaagggtcg 2954521 cctctcatgt gatagccatt ccgctcccaa aagccagggt gattttcttt cgtaaattgg 2954581 atgccgcgca gccacttggc gcttttccaa aaatacagat gcggaaatac accccgcagc 2954641 ggaaagccgt gttcaggggt taaaggttcg ccattatgcg cataagccag aagggaagtt 2954701 tccgctaaga aatcatcaag cggcagattg gtcgtccagc cctcttcagc atgtaaaatg 2954761 acgtagcccg cttcttcttt tacacccgct ttttccgcta tatcacaagc ccgcacgcct 2954821 tgccacacat tatcaagcct tgaccatccc gtgacgcaat gaatgtcgtt tttcgattca 2954881 taccgtggaa aggctttgac atcttcaaag cttagcagca tcggatggtc aaccaaaccg 2954941 tatacttgaa gattccattt cgtcatatct tcgtaatatg ggacatctcc ggtatgaagc 2955001 acaggaaatg aagtggtgac gttttgattt ggcggcactc ttccagattg atcggactgt 2955061 cttgtttttc cgaaatacat atgggcctcc tttttgttaa cctaatttaa aatcatgttg 2955121 acaatctttt tgttctttat tactctatga ttgtgtatgt caacctaagg gggaacaacg 2955181 atgaaacaac gtaaacttcg tgcgggagat atggcgctga ttggcatgtt cgccgcactt 2955241 atggctgtcg gggccaacat tacatcagta gcaccctttt tacaagtagc cggcattccg 2955301 ctttcgatgc agccgttttt ctgtctcttg gcagctttgc ttcttggcag caaacgggca 2955361 gcgattgcca tgattgtata tgcacttgtg ggattggccg gagcgcctgt gtttgctcaa 2955421 ttttcagcag gcttcgcacc gtttgcaggg aaaagcggcg ggtttattat ctcatacatt 2955481 ccggcagcat ttgcagcggg atggttttta gaacgaaaca ttcagccaag taaaattcga 2955541 tttctcattg cttcacttat cggaacggcg atcatgtatc tcatcggcac tacctatatg 2955601 tatcttgcac tgaagctgtg gattcatacg ccagtgagct acggcacggc ttggggcttt 2955661 atgatttggt ttatggtaaa agatacagcg ctggctgtga tactgtcgtt tatcgcacca 2955721 gcaatctacc gctctattca taaagcaacc ggctttaaca gaaatcacat atcatctacg 2955781 taaaaaccgt tctattggac ggttttttta tcataacgag aaaaggctcc ccagtaaagg 2955841 ggagcctttt tcctataaaa caagcgctgc aatccagcca aagatgacaa gcggaatatt 2955901 ataaaatata aatgtcggca cacaagtatc ccaaatgtgg tgatgctggc cgtccgcact 2955961 caaacctgaa gtcggcccaa gcgtactgtc actggcaggt gaaccggcat cgccaagcgc 2956021 agcagcagcc ccgataatcg caatcgttgc catcgggctg aatccaagct gcatgcatag 2956081 aggcacgaaa atggttgtga taacaggaat ggtcgcaaaa gaagatccga tccccattgt 2956141 aattaataag ccgacaatga gcatcagcaa tgcgcccaag gactgactgt gtccgataaa 2956201 accagctgac gttttgacca gtgactcgac atctccggtt ttcgtcaata cgtttgaaaa 2956261 tccggctgca acaagcatga caaagccgat aaaggccatt aaaaccattc catcagtaat 2956321 cagtgagtcc gcttcatcac gcttcatcac accgctgaca aacagaacaa tcagaccagc 2956381 gagcgccccc ataatcattc cttctactcc caaagtctga gataagtaaa gctggacgcc 2956441 gagtgacaca acaatggcta gaaccgcgat accaatactt tttctcgtat atggcgatgc 2956501 ttctgcacct gaaatgtctt ttgtttcata ttgtttcggt ttacggtata cgatcactga 2956561 taaaataagg ccgacaacca tacctgcaac tggaataatc agtgcgtacg gaatatcagc 2956621 aagcggaacg tttaacccgg catccgccat attgtccttc agcatgcctt ggaagatttg 2956681 gccgaaaccg accggaagca aaatataagg agccgttaag ccaaatgtaa ttacacacgc 2956741 gatcagacgg cggtccattt caagttcatt aaagattttc aaaagcggcg gaatcagcac 2956801 cgggataaac gcgatgtgaa ccggaacgac gttttgcgaa aaacaagata caattaaaat 2956861 aatcagcaca atcagcacct tagacagtgc tttttttcga gaatcttctt tatttccgat 2956921 taatttaacg gaggcttcca ccattgcgtc cggaagaccc gttttcgtca aagcggcggc 2956981 aaacgcgcca agcatggcat agctaactgc aacggtggca tttccgccga gaccgtctgt 2957041 gaaagcttta accgtttcgc caagaccgag cccgcctgtt aacccgccgg ccaaggcgcc 2957101 tataattaat gcgataacaa tattgacacg cagcaggctt aatacaagca taagcaggac 2957161 tgcgatgacg actgcattca tgatgatacc cctccaaaaa tcctttagtt tgctaatgta 2957221 gtagataaat aaagtacgaa cgtatcgtat cataaccgat ccactttagt caactaaaga 2957281 tttcggaaga aaaaatccct gccgcatcat acagcaggga tttttcatta ctcgttttta 2957341 tcttcttcca atgtaaatcg ctccgcaagt gtagccagtg ttcttgccat aacgccagta 2957401 gccccggccg gtccgaagca ggttgcttta ttggcagtcg ctgtgcctgc aatatcaagg 2957461 tgaacccaag gtgttgactc agcgaattca ccaagaaacg ttcctgccat aatcgcatgt 2957521 ccctcgcgtc ccggtgaatt gctgagatcc gccatttggc tgcttttcac gcgtttttta 2957581 tccttctctg ttatcggcag ctgccagatc gcctcgccgc actcttgtgc agcatcagct 2957641 acctgctggt aaaagctttg atcatttgtc attgcaccgg ttgtttctgt tcctaatgcc 2957701 acaacgacgc cgccggtaag cgtagctaca tcgacaagaa ctgatgcgcc atgctgtttc 2957761 gcgtatgtaa tgccatctgc aagcactagc cttccttcag catccgtatt aaggatttct 2957821 attgtttttc cgcttaaaga tacgatcacg tcatccggct tcatggcccc gccggagatc 2957881 atattatcgg ttgatggaat aacgcacagc acgttttgtt caggacgaag ctctccgatc 2957941 gtttccatag ccccgagaac cgcagctgct cctcccatat ctgatttcat gccaacaatt 2958001 ccagatttcg ttttaatgga gtagccgcct gtgtcaaagg taattccttt cccgactagt 2958061 ccgacgacgt cttcccattc ctttttgccc tgatatttca acacaatcat tttcggcggt 2958121 tcggtggagc cttggtttac cgcaagtatt ccgcccatac cgagctcttc catctctgat 2958181 ttctccaata tctcacactc aaaatcatat ttcgccgcaa gctcttcagc atacgaagcg 2958241 aggtcagtcg ctgtcagcat gtttcccggc atattcacaa gcgttctagc cgaatttgtc 2958301 ccttgtccgt atgcctggcc gacgcgaagc cctgcctgca cttcctgtgt atcttcatct 2958361 gttacaacat acacggcttc aatttgtttg tcaggctcat ttgatttatg cttataatcc 2958421 tgcacctcat aggaagcaag caggcagctc tcagctaaag catgagcggc atcggctgga 2958481 ggcacgtctt ccgaaataaa cgtatcaagc agaacagcag tttcttgttt tcgatcttta 2958541 tgaatggctt gaaaaacatg agcaaaacgt tccttcgcct gttcaaacga ataatttgct 2958601 tctctcccca ggccaacgaa ataaatccgt ttcatacccg cagaagatgg agggaatact 2958661 tttgatactt gattcggttt cgcagagaca tcaccctctt ttaaaagctg tgtcagatgg 2958721 ccttcgagca tttcatcaat ttccaacgct tttcctgtca gctggctttt ttgaaaaagc 2958781 ccgacaacaa gggtttctgt atgctctgat tgttgaaccg cataaaacat gaggcttaca 2958841 ctcctaacgt aatgggtatt tgtaatgaac aatggtataa taggaaaaac attctttcca 2958901 ctatacttat tttaacaaac aacagtctaa gacttgcttt tttcttttga aacacgaagg 2958961 atttttcaaa tagaaaggat gtcgccgatg gaacttttaa cgaattttcc tttattatca 2959021 agcctggccg caattatttt tgctcaggtc atcaaagtgc ccatacagtt tatcgtgtcc 2959081 agaaaactgg actggtcgct ggtcacaagc acaggcggca tgcctagctc tcactccgca 2959141 gcggtcactg cgctttctac aggcgtagcc ttggagcatg gattagactc ctcactcttt 2959201 gcggtttccg ccattttcgc cgtcataacc atgtttgacg caactggcgt cagacgtcac 2959261 gccggtgagc aggcaacagt cattaataag cttgttattg attttaaccg tttcgtaaat 2959321 gaagcgaagg acttccctaa ggctgcagag aaagaaaagc aaaaaaagct gaaagagctt 2959381 ctcggacatc agccgatcga agtctttttc ggaggattaa caggtatttt actgacattg 2959441 gtactcgctt actttttcat gtaaaaaaaa cgctcctgct ttcgctggag cgttttattc 2959501 tttcaccgtt ttatattgat ttctgaacac ttgcaaagat tttgtttcat tgagcttctc 2959561 aagctcatcc tcggtaatct ttcccgttcc ctttttaatc acatatacat caagggtttt 2959621 tttgccccat tcattgtata catctttgac tgtctcaaag tacagatcaa ggcggtttcc 2959681 cttaatagct gatcctgtgt cggccacaac tccgagaccg tagttcggaa tgaataaaat 2959741 tgttccgatc gggaaaacgg acgggtcagc agcaaccgtg gaatataaat cccgtttcac 2959801 tttcacacct gaatatgtaa gcccgtataa tggatcaccg ggatttttgc ccgtcgactc 2959861 agctcctgct gtgtagcctg ttgctgttac tctttggact ggatattcat cccaatcaaa 2959921 tgcctcttct aacggttttg ttttatcctc agccgcggac gtggtttgtg tttgtttctg 2959981 ctgcaatgct tttaatctca gtcctgcatg cttcaagtgc ttttcctgat gttcctgcac 2960041 ccattttgac aagtccttcg cttcaattcc tgacactgat aaaaatgtcg tgccaaatgc 2960101 aagcagaaat aaacaggtca tcagcaaacg tctgatcata ttcaacatca ttcacctctc 2960161 ctccgaatca ttgttcccaa gtggagagag cattattcaa aatggtgaat gagctgaacg 2960221 cataaaaaaa gctttcttta gaagaaagcg gcatttaaaa catttgatat cctctttttc 2960281 taagcatgtt gatcgctata ccggacacga tggcgccggc caaaccgctg actaaaatca 2960341 gcacatcagc agccgctaat gataagacac gatgaaacag gctggcaaag gattctcccg 2960401 gcgactggac atagctgatc agcttttctt tgctgataat gaaaaggcat acaattggat 2960461 aaatcacagc cataatccaa gacattctca gcagcatgtt taataagaaa ccgattccaa 2960521 aaaacaagac aaaaaacaaa acaattgaga tgattacgac tggcagacta atcaacctat 2960581 tccacccccc tgcgttgttt ttagtgtaac gcgggggctg aaataaagtc aacggctgga 2960641 aaaagaatga ctgtcttttc ctgtcccctg gcaagacgga caagtctctg aaccgccgag 2960701 aatcaattga aaatatcctt tccctgaaca aaatgggcat gcatgtgaag cggttgtcgt 2960761 tgcagttttc atctaatcat cacccttttt cttaattttc tgataatata ccatatcaag 2960821 ctgtcaacaa taaagtcaga tcatgtgaca aatcttttga tgtaagcgga aacatacttg 2960881 ttttcctctc gttctctttt tattttggcg ttttttaata aagaaaaccc gcttccgcgg 2960941 gtttttagaa aaacttgaac ttgccttttt tcaatgtcag tccgagtccg ccaatcataa 2961001 acagtgagcg gttatcaatg acttttttca taaacgaagc gggcgtgcct ttcagctttc 2961061 tgccataaac aaccccaacc gcgttatgct cgccaagaga agccactgtt cccttaatgt 2961121 ccggcttgaa ttcctcaagc tctccgcctt taataagcct gccaaggttt ttagcgaccg 2961181 ttatgccctg ctgcattgca atttgcgcag tcggcggata cgggcgctct gtatcttcat 2961241 tcataaacag cgagctgtcg ccgagaataa agacattgtc atgtcccggg gcgcggagat 2961301 cagggttgac tttgactcgg ccgcgcatat tctcaaaacc ggcttcctcc acaatcggat 2961361 ggccgcggac acctgccgcc catacaacgg tttgcgattt gatctgctct ggttcttcat 2961421 cttttttgcc gactctgact ccttctggtg tacattcttg tacagccgtt ccgatcttga 2961481 actcaactcc gttttcctca agataatgta cggcgtaatc aacaagttcc ggatcaaagc 2961541 ccggcaaaac ggtcggcgct gcttccacac aaatgatgcg gacaaggctt ctgtcaacgt 2961601 catattcctt acagagctcc ggcacgcgag cagccagttc gccaagaaat tcaattcccg 2961661 taaatccggc accgccaaca acgatcgtta acctgtccgg ccgtttttcc gcttccgtat 2961721 tgtaagtcgc aaactgcagc tcaatatgtt cccgcagcag gcgcgacgtg ttgatgttgg 2961781 caatcggaaa cgcatattct tttaagcctt taatgccgaa cgtttcaggc acggcgccga 2961841 gcccgatgac taaataatcg tactgcaatt ctccattcgc aagcacaact tttttctcat 2961901 caattttgat tgcctttacg gtatcctgta caaaattcac ccgtgactgg ttgattacat 2961961 cttttatctg ataacggcag cggtcatgat ggagcgtacc cgcgctcgct tcatgcatcc 2962021 atgtcgtttc ataatgataa ttgtgtttat ttacaagcgt aatgtcagca tcattcggcc 2962081 cgacatactt cgtcagcctt gtcaccgtca tcaatccgcc atatcctgca cctaaaatca 2962141 cgattttggg cttattcaat gccatcacat ccaccttctc tttttttgct tttgttagac 2962201 ccataataaa atcatcattt gtgttagctt cagcttattg gcgggatttt atgaaatata 2962261 ttgaaaagtt ttttgtgaag tccttacccg tagcactatt atcatgttta tccggctggc 2962321 ccaagaaaca ttcagaaaaa gatcatttca tttggttatt atcgtagcgg cctgcggaaa 2962381 tattttcaag aacggatggg cacgttagat ccttacgatt ttttctgctg actcgtcaat 2962441 ttgaacggca atatggtata attaataaca attttcattt aggaggcaat tttcgtatgc 2962501 gagaggatac aaaggtttat gatattacaa ttataggcgg gggaccggtc ggcttattca 2962561 ccgcttttta cggcgggatg agacaggcaa gcgtcaaaat tatcgaaagc ctgcctcagc 2962621 tcggcggaca gcttagcgcc ctataccctg agaagtatat atatgatgta gcgggattcc 2962681 cgaaaatccg cgcgcaagag cttatcaata acctaaaaga gcaaatggcg aaattcgacc 2962741 aaaccatttg tctggagcaa gcggttgaat ctgttgagaa acaagcggac ggcgtgttta 2962801 agcttgtaac aaatgaagaa acccactact ctaaaacggt catcataact gcaggaaacg 2962861 gcgcattcaa accgagaaag ctggaacttg aaaatgccga gcagtatgaa ggcaaaaacc 2962921 tccattactt cgttgatgat ctgcaaaaat tcgccggcag acgcgttgcg atccttggcg 2962981 gtggagattc cgcggttgac tgggcgctta tgcttgagcc aatcgcaaaa gaagtatcga 2963041 tcattcaccg ccgcgacaag ttccgagcgc acgagcacag tgtggaaaac cttcatgcgt 2963101 cgaaggttaa tgtcctgaca ccattcgtcc ctgcggagct gatcggcgaa gacaaaatcg 2963161 aacagctagt gcttgaagaa gtgaaaggcg accgcaaaga gattttagaa attgatgact 2963221 taatcgtcaa ctacggtttc gtttcatctc ttggaccgat caaaaactgg ggcctggaca 2963281 tcgagaaaaa ttccattgtc gtgaaatcaa caatggaaac aaatatcgaa ggcttctttg 2963341 cagcaggtga catttgtaca tacgaaggaa aagtcaacct gattgccagc ggcttcggcg 2963401 aggcaccgac agcagtgaac aacgccaagg cttacatgga cccgaaagcc cgcgtacagc 2963461 ctcttcactc aacaagtctt tttgaaaata aataataaaa aaaggagctt gtgtctgcga 2963521 cacagctcct tttttatttg aagatattta tataattcaa tgcagttcct acaaccagcg 2963581 caatcacaag ggctgcgact acccagatca ttgccataat aatgcggtcc tgaatctttt 2963641 gggacttcgg tgttttttct tcgttttggg ccatcttatt cgctcctttc ccatgtccat 2963701 gccataaaga aagcctggtg ctgaacgacc aagctttgct gaacgtatat cattcgcgtt 2963761 ttgatccgct ctctaagacc attcgttaaa actatgatac ctaaactcac cctgcatgac 2963821 aagcttcggc acttgcacca cacctgccag caaatcataa tgtttgacat cctaaataaa 2963881 acagagtaca ttatataagg cgaacatttc atatattata cttttaaata ttcgttttta 2963941 ggagtgaaaa ccatggaaaa cgtatttgat tacgaagata ttcagctaat tcctgcaaaa 2964001 tgcattgtga atagccgttc agaatgtgat acatccgtac gtttaggcgg acatacattt 2964061 aaattgcccg tcgtccctgc caatatgcag acgattatag atgaaaaact agcgatttca 2964121 ttagccgaaa atggctactt ttatgtgatg caccgatttg agcctgagac acgaattgat 2964181 tttattaaag atatgaacgc acgcgggtta ttctcttcta tcagcgtggg cgtcaaagat 2964241 gaggagtatg aatttgtccg ccagctggca gaagaaaatc tgactcctga atacgtgaca 2964301 attgacattg ctcacgggca ctcaaatgct gtcattgaaa tgatccagca ccttaaaaaa 2964361 catttgccgg acagctttgt tattgctggc aatgtcggaa cgccggaagc ggtcagagag 2964421 cttgaaaatg cgggagcgga tgccactaaa gtcggcatcg gaccgggaaa agtatgtatt 2964481 acgaaaatca aaacaggctt cggcacaggc ggctggcaat tagcagcgct gcgctggtgt 2964541 gccaaggctg ccagcaaacc gattatcgcg gatggcggca tccgcaccca tggcgacatc 2964601 gcaaaatcaa tccgattcgg cgcaacgatg gtcatgatcg gttcactatt tgccggacac 2964661 gaagaatcgc caggccaaac gatcgaaaaa gacggaaagc tttacaagga gtacttcggc 2964721 tcagcctctg aattccaaaa aggcgaaaag aaaaatgtcg aaggcaaaaa aatgcacgtg 2964781 gcgcataaag gctcaatcaa ggatacactg attgaaatgg agcaggatct tcaatcttct 2964841 atttcttatg caggcggaac aaagcttaac gccatccgca atgtggatta tgtgattgtg 2964901 aagaattcca tttttaatgg ggataaatat taatcataaa aaaacgccaa gtcagcggtt 2964961 ctccgcttga gttggcgttt tctgctactt cttcagcaaa gtaagcttat atttgctttt 2965021 tgagtttatc ttccatcagt tctgccattt gttttgcatt tggattttct tcattttgca 2965081 actgttcaat gacgttcata taatccgttt catttcggtt ctggcttaat ttatatgccg 2965141 cttgaatgtc ttccacctta atcttaaatc caacaatacc tttcaattca ctttctaaga 2965201 gttttggaga aagcttatcc cataacacag gattgtcacg atgtttttcg tatttctcca 2965261 acatgattgt taattcttct gctaattcat ctttctctaa catacttgct tttccataca 2965321 tgtggacagc ctgataattc cacgtcggaa cattttcgcg cgaataccag gaagaagaaa 2965381 tataagcgtg cggtccctga aacatcacaa gcacatcttc acaggcttca aacgttctcc 2965441 actgaggatt tccataagcg aaatgccccg taatatagta atgatcgtct tttttattga 2965501 atcctaacgg caaatgtgtg gcaattggtt ttccttgttc tgttgtgaca accgtaccaa 2965561 aggagttttc ttgtacaaaa ttccaaattt cttcagcatt tgtgacttta aaatattttg 2965621 gaatatacat catcatccac ccttcgaaaa atattatatg agtgttttag ccatgattaa 2965681 atccgtttgt tcttcatcac ccatataaaa tgagtgggcg ccggtctgaa caaaccccat 2965741 tttcttataa aaggcaatgg cattttcatt tttttcccac acacctagcc aaatgttctt 2965801 tttattacgt tccagcgcaa tttctatcgc tttattcagc agatgtttgc caagcccatg 2965861 tttttgaaag ctgttcttta tataaattct ctcgatttca agtgattcag cacccatttc 2965921 ttcagactga gcatcatcga tattgacctt tacatatcca gcgatttcat gatcaaagta 2965981 aataaaaaag aattgcgaag acatattaga taactctttt tccagctgct cagtgttaaa 2966041 tgcgctttct aaataggctt tcatattttc aggtgagttc tgttctttaa aagtgtcatt 2966101 gaatgtttca atactcaatt gttgaagtgt ttgtaaatct tcccggctgc attttttcat 2966161 ttttacactc attgttcgga ttcagcccct ttatttaaaa ttcaattgtc ttgtgtccct 2966221 tttatatatt taaacacgga acacatactg accttgttac cattccaaaa atcttcttca 2966281 tcaccaactc cctatcgtga ttttgttgta aatgcaataa aatatactcc gcattaaata 2966341 tatcgtaact ttgctgtatt tacaacaaaa atcaaacaac aaagcagcgt ttctcttgcc 2966401 gaagttcccg gaactctctg catcatttcc ccataataaa aacgcctccc ttaacgatga 2966461 tttatcgcta agaaaagcgt cagtaatagt tgctatccgt ttttagtgct tagcactctt 2966521 caggcttgcc tgcattcgtt gctgttctga acgaagaacc gcagccgcat gaagcgatgg 2966581 cgtttggatt gtcgatggtg aagccgccgc cgagcatgga ttgtttataa tcaatcacgg 2966641 tgccgttcat gatgtcaagg ctttctttgt caactagaac agtgatgccg tgctgatcaa 2966701 acacactgtc tgattcactc ttttcatgct caaagcccat gccgtaagaa agtccgctgc 2966761 agccgccgcc tttgacgcct acacgcagaa acgcgttttc ttcttcatgc tctttcatca 2966821 tatcttttat atgcaaagct gctgcttctg taattgttac cgggttgctc atcattatga 2966881 acctcctttt aaaaaccggt tgctgtcttt tattataaac atgatcgttc caattctcaa 2966941 acaaggtgtt ttacaagaaa tagacaccct cacaaacggt ttcagccggc cctgtcatca 2967001 ttacatggcc gttatctttc cagtttatca ccaaatcccc gcctgctaaa tgcaccgtga 2967061 tgtcttgatt tcgctttgat acgccgttta atacagatgc gactgccgct gcacatgctc 2967121 ctgtcccgca tgcctgagta atccctgatc cccgttccca gacgcggaaa tgcaattctt 2967181 gttcattcac ggtttcaacg aattccacat tgatgccttc cggaaatctc ggatctttct 2967241 caatcaccgg ccccagtgtc gttaagggtg cctgttcaat gtctgcgatc ggaaaaacga 2967301 tatgcggatt tcccattgaa acggcagtgc ctgttagttc tacttcacca aatgccatcg 2967361 tttcattgat tgtgtgctct tccccgccgt caagcatagg aagctcggat tttgtcaagc 2967421 gcggttcgcc catatcgaca gtgaccacat tcacttttcc gttttcgact tgaacctccg 2967481 ctttcacaag cccggagaga gtttcaatca gaaaagatgt ttcctcaacc agcttatgct 2967541 catatgcgta ttttgcgacg cagcgcaggc cgttgccgca gtttttccct tcagacccgt 2967601 cattattaaa aatccgcatt ttaacaggcg cttggtctga tgggcatatc aggatcattc 2967661 cgtcggatcc gatccctgta taaacagaag aaacctgaat tgcaatctct gacagttttt 2967721 cttctggaag ctgttcttca aattgattca cataaatata actgtttccc aggccgtgca 2967781 ttttggtaaa tcgaaatgag ttcataggtg cctccaactt tttttctttt tcttagtata 2967841 aaagctatta taagcggaca caatacaatt atcccccgtt tttcatacat aaaagctcct 2967901 tgcactgacg caaggagctt ttatcgttta tataaacatg ccggcaatgg ctgcgctgag 2967961 cagattggct aatgttcctg caagaacagc cttcaggccg agacgtgcga tatctgaacg 2968021 gcggctgggc gctaaaccgc caagcgtacc aagcataatc gcaattgatg aaaaattggc 2968081 gaatccgcat aacgcgaaac tgataatggt agcagttttc ttagaaaact cgccgatgtg 2968141 cgaaccgaag ttagaataag cgacaaactc attcagcacc aatttctggc cgatatagct 2968201 tcccgcctgc aatgcttcat gccaaggcac gccaatcaaa aaggcgatag gagaaaacac 2968261 atagccgaga atggattcta atgttacgcc ttttaaaccg aacaagccga aagccccgcc 2968321 gagaataccg tttactacag cgattaacgc aacaaacgca agcagcatcg ccccaacatt 2968381 taacgcaatt tgcagtcctg ttgacgctcc ctttgcagct gcgtcaatga cattggctgc 2968441 gccttcgcct tcatccattt tgaaatcgct ttttacggtt tgcgtttttt ccgtttcggg 2968501 tataatcaat ttaccaaaga ctagtccagc tggagcagcc ataaagctgg ccgccagcaa 2968561 gtactcaatc ggaataccga gaagcgcgta cccaaacaag gtagatcccg caactgccga 2968621 tagaccgctc gtcataatcg taaacaactc agagcgcgtc agcccggcaa tcaggggttt 2968681 gatcactaac ggagattctg attgtcctac aaaaatattg gcagcagccg ccagagattc 2968741 cgttttgctt gttccaagga gcttcgacaa tccgccgcca atgacacgga aaacgagctg 2968801 catgattttc aaatgatata aaactgcaat cagtgctgag aagaaaatga taacgggcag 2968861 tacacttaat gcaaatgccg gactgtctcc gacctttaga agcggtccaa aaataaaact 2968921 gatgccttca ttcgcatagt caatcagaag ctgtacacgg cttgaaaacc ataaaaaaac 2968981 agcgcgtccc gcttcccatt tcaacacgat gtatccaaac gccacctgtg tgcataaacc 2969041 aacgatgacg gttcttatct taatattgct tttcttttct gaaaataaaa acgcgatagc 2969101 aatgatcgca actgcgccca gcagccccca cagaacattc atgaatactc gtacacctct 2969161 taaattttat ttaaaaaaat atcttttata cgataacaat aatatttttt gatgtctaca 2969221 cattttttta gttcttttgt acggcaaaat aaaaaagggc ctgtccaggc ccttttcttt 2969281 aaaacattgg attttcttca ataaaggtat atatattctc aacaagctca gcaggcgttt 2969341 cacccatgac gacttctccg tttaccagag cgaaaagcga ttccatacat gtcccgcagt 2969401 agcttaagca gccatattca aggacatcaa ggttgggatc cttctccaaa atcgcccggg 2969461 cttcctgaga gccgtgagcc agattgctga cacaaaattc aatcattgga ttcatgcggt 2969521 ttcacctcac atatgtccat tatcgcgaat ttttcactat tcgtcaaaga caacggatga 2969581 ttcaaaattt attatcgtaa catattattt ctcaaataac gttttactaa tttgtgtttt 2969641 caggctaaat tgtaggttat tttgaaacta ttattgtgat tttagatcaa attcgatata 2969701 attctagatg ttattttaca tagttcgtat tttcttcaat gtatctatca tactcttcgg 2969761 attaaagggg aattcaaatg aaaaaattgg tcttgatcgg cggaggttac gggaacatgc 2969821 gcgttcttca tcgcttattg ccaaaccagc tgcctgatga tgtttcaatc acgttaattg 2969881 acagaaatcc ttatcactgc ttgaaaacag aatattatgc ccttgccgca ggcacaattt 2969941 ctgaccatca tatcagagtg tcattcccag agcaccctcg cctggatgtc caatacggtg 2970001 atatcacatc aattgatatt gtacaaaaac aagtgctgtt ccaagatcgt gaaccgattt 2970061 cttacgatga cgccataatc gggctcggct gtgaggataa atatcacaac gtgccgggag 2970121 cgcctgaatt cacctacagt attcaaacca tcgatcagtc ccgcgaaacc taccaaaagc 2970181 tgaataatct gagcgctaat gccaccgtcg ccattgtcgg agcgggctta agcggcgttg 2970241 agcttgcaag tgaattgaga gaaagccgtg atgacctgaa cattattttg ttcgaccgcg 2970301 gtaatctcat tttatcaagc tttcccgagc gtttaagcaa atatgtgcaa aaatggttcg 2970361 aagagcacgg tgtccgcatt attaacaggg caaatatcac aaaagtagaa gaaggcgttg 2970421 tgtataacca cgatgatccg atttctgcag acgccatcgt gtggacagcc ggcatccagc 2970481 caaacaaagt cgtcagagac ttagatgtgg agaaggacgc acaagggcgt attgtattaa 2970541 cgcctcatca taatcttcca ggtgatgaac atctgtacgt tgtcggcgat tgcgccagtc 2970601 ttcctcatgc accgagcgcc cagctggcag aggctcaagc agagcagatt gtccaaatct 2970661 tgcaaaaacg ctggaatgga gaagccctgc ctgaatcaat gccgcagttt aagctgaaag 2970721 gcgtcctcgg ttcactcgga aaaaaagccg gcttcgggct tgttgctgac cgtccgctga 2970781 tcggccgtgt tccgcgtatg ctgaaatccg gcttgctgtg gatgtataaa caccataacg 2970841 gttaatgata gagaagaacc gctgatcaag tcagcggttt tctgtatacc catgcttctc 2970901 catttcctca taaacgtctt ttaattttgg attgccttca ccgacaattt tgtcttctac 2970961 aagcacaagc ggataaaaat actcgtcatt tctgattttt tccgcaagct ctttcgcatg 2971021 ttcattgtca ggcggctcat gaatatcgat gtactgcatc tcaaaaggct gatttggata 2971081 ttttcttttc agcgcagcct caagccactc gtatgtatcc ttggctgtcg gcatatttac 2971141 acagctcgca caaacgtttt ctgccccgta cacgcttagc atgactggtt tcatcacttg 2971201 tagacgcccc cttctcctat gtaagtcctt tcttttaagt atacagagcc taagggcgtt 2971261 tttatagaaa aaaaccgttt ttgtgttgaa gtctgaatgt gctataatag ggaaagcaac 2971321 tttgcaaacc aaacaataga tttttattgt tacactgaat ataatggttt tatgacgacg 2971381 aaaggagcga atgtcatgac tgaagttgaa atgaaagaac aggtgcagga agtactggac 2971441 aaacttcgtc cgtttttact tcgtgacggc ggtgactgtg agcttgtaga cgtagatgaa 2971501 ggtatcgtta agcttcgtct tctaggcgca tgcggcagct gcccaagttc aacaattacg 2971561 ttgaaagccg gaattgagcg cgctcttctt gaagaagtgc cgggtgtcgt tgaagtagaa 2971621 caagtctttt aataaagcag ccaggctgat atttgatcag cctggctttt ttattagaga 2971681 tgttgatcaa accatgagct gatataattc aggcgcttga tccgctgtct tgggtgtccg 2971741 gtgcgtgata aattgtgcga tgcattcgga aaacggacaa gcttggtttc cttgcccatt 2971801 tttttcagag cgataaacag ctgctccgcc tgctcgatcg ggcatcggtc atcccgctcg 2971861 ccatgcagta tcaaaagcgg tgtctccacg tttgctgcgt attttaaagg agaccggtcc 2971921 cagagctttt ctgtgtcctc aaacatgtca tgctcaagct gccagtctgt aaagaaatag 2971981 ccgatatcac tgacgccgtg aaagctgatc caatttgata tcgagcgctg ggtaacggca 2972041 gctttaaagc ggttcgtctg cccgacgatc cagttggtca taaaacctcc gtagcttccg 2972101 cccgtgacac cgagccgctt aggatcaata tgcggatctc gtttgatagc ctcatccaca 2972161 gcctgcatca catcgtcata atcctttccc ccataatctc ctctgaccgc attcacaaat 2972221 tcctgcccgt agccgtggct tcctctcgga ttgatataaa cgaccgcgta tcctttcgcc 2972281 gccagcacct gaaactcatg aaaatatgta tgtccgtaca tcatatgcgg accgccgtgt 2972341 atgttaagaa taagtggata tgttgtctca ccttccattt gtgcaggcct catcagccag 2972401 ccgttcacca tcacgccgtc ttctgtagca tattgaatct cttcaggtat tgatatcgta 2972461 tgctccctga caaacttgtc attcgcgcca gtcagctgtt tctcttcctg tccaagcggg 2972521 atactgtaaa gctcactcgg tctgtccggc tttgtcacac tggcaataaa gtgctgttca 2972581 tcaggtgaaa gagaaaagct attgatgtac tctttttcca gacgaatcgg atacacaagg 2972641 ccttcaatcg aaatataata gatgcccgta ctgccttgat ctgtgccgat gacataaaac 2972701 ccttggctgt cctttgtcca aatcgggcgc tgttcagcac caccgatcaa tgaatctcca 2972761 atcagcgcat ccgctaaatg aacgtccagc atctcagtaa gacatgtgag gcggccttgt 2972821 tcgatatcat agagccacgc ctttgagagc gtagcattct tatattcctt ttcatttcca 2972881 agcaaagcaa gataccttcc gtctggtgaa aatgagcttg atccgaatga gccgcgatga 2972941 ggtgtaacct gcttaagatc tccagactcc agtgacatta tgtaaacatc atgcggcttg 2973001 ctggcatcat ctgtttcagt taaattagct gagaaaacaa gccatttgcc gtcaggagaa 2973061 aaagcaggat caccatgatc agctttgtga cttgtcagct ctttcatctc acccgacttt 2973121 acgctgacaa gcacaagctg ggcatacgca cctctcgtca gccctttgcc gtcccgtttg 2973181 taggagaggc cttgcacttc aacaggttca tagctgtcct gctctgtttt ttctcggtca 2973241 tcaatgcttt ccccctctcc caaactgaca gtgaccagaa tcgattcacc gtccggggac 2973301 catagcggct ttgacacgcc atatgggata tcagtcagtt ttcttgcttc tccgccttca 2973361 gtgctcatga tataaagctg tgccgcatcg ccttctcgat cagaaataaa ggcaagcgtg 2973421 cgcccgtccg gagaccatct tgggtcggtg cttcgctttt ctccatgtgt ccaaggaaca 2973481 gatcctcccg ttttcgtttc atagatccat atatttgatg tatacgaatc tttctcttga 2973541 tttacttgtg attttacata tgcggcacgg gtaccgtctg gggcgtattg aggatcggtc 2973601 acagagacaa tcgctgtgat gtcgtctgcg gttatcagct ttttcatatt catctcctcc 2973661 tttttacatg tatttcgttt ttctaaataa aaactccttt atctccagca aaaaaaagcg 2973721 ccctccgctg acgctgagga acgcttggca tgatctatac actttttact tgatataaag 2973781 gatttcgctc tattatactt ccctctttcg gaacggtcaa agcgtctact tcacaatgag 2973841 ggaaatgaag cgcgagctgt tcttttagct cttctccctt tcctttttcg gtcatgacga 2973901 gaatcgttgg gcctgctccg ctgagagccg ttccatatgc gcccttcatc tcggcgacgt 2973961 gctctacttt tgacagctca ggcacaagca tcgcccggta cggctgatgg aacatatcct 2974021 tcttcatgat tttcccgaca agcggccaat ccttggacat gatcgcagca atgaggatat 2974081 tgctgacagc acttgctttt acggcatcgg catatggaaa ctccttcgga agcacgtctc 2974141 tcgcgtctct tgtcagcact tcataaaaag gaatgacaac gactacgtca atgtcagcat 2974201 tcgggacgcg gatcatttgg gtctcgtcat cctcatgcag gccgatcaca agtccgccga 2974261 cgagagaagc gccagcattg tccgggtgtc cttcttctag actcgctaaa tgcagcttgt 2974321 ccgcttcaga cagctttaag ccgcataatt catcagccag ttcaatggcc gctacaatcg 2974381 ctgcggcgct gctgccaagg ccgcgtgcaa gcgggatgtc gctccacacc ttcacatgga 2974441 caggaggcat ttcttttccg tacaaatctg cggtccgttt agccacttgg tagatcaggt 2974501 tatctgtacc cgccggaatt ccggcgactg tttctgtttc agcctcaaaa gaccatttgt 2974561 cgctttcaaa gacggtcagc ttcaaatatc tgctgagcgc cattccgact gaatcaaagc 2974621 cggggcctag gttagctgtg cttccgggaa cagtgacaga gaacagcatg tcggcttcgt 2974681 tcatacacgg gccgctcctt ttacatattc aaggatgctg tcttcatcag tcggcaatgt 2974741 gacaggcttg atttctgaaa tgtcgaccgc tgtgttcgga tctttcagtc cgtttcctgt 2974801 taacacagct acgaccttgc tgcctttcgg aatttctccg gatttcacct gtttcagcac 2974861 tcctgcgata gacgcgcaag aacctggttc tgcaaacacg ccttctacac gggcgatcag 2974921 ctgatatgcg tgaaggattt catcatcagt gacttcgtca attttcccat tggattcctc 2974981 ggctgccttt acagctttgt cccagcttgc cgggtttccg atacgaatgg ctgtcgctat 2975041 tgtttccgga ttttcaatca cttcattgcg cacgattgcc gccgcaccct cagcttcaaa 2975101 gccgcgcatt ttcggaaggc ctgtgccgtt tttctcatga tattccttga agcccttcca 2975161 gtacgcagtg atgtttccag catttccgac cgggatcgct aaaacatcag gcgcttcccc 2975221 cagctgttcg cacacttcga aggcagcagt tttttggcct tcaatgcggt aagggttgac 2975281 tgagttgaca agggcaatcg gtgatttctc acagatggaa cggacaattt taagcgcatc 2975341 gtcaaagttt ccgtcaattg cgataatctc ggctccgtac atgacagctt gagcgagttt 2975401 tccaaatgca atttttccgt tcgggatgat gacaatgcat ttcatgttag cacgggctgc 2975461 atatgctgcc gcagcagcgg aagtgttacc tgttgacgcg cacataatcg tgtcattgcc 2975521 ttcttctttt gcctttgcca cagccataac cattccgcga tctttaaatg atcccgtagg 2975581 attgacgcct tccgttttga catgaagctc aattccgagc tgctcagaca gcttcggcag 2975641 gtgaataaga ggtgtgtttc cttcatgtaa agttagcgcc ggtgtttgat ctgttacagg 2975701 taaaaattct ttatattgat ggataagtcc tttccacatt agctccaacc gttcccttct 2975761 acacgatatg tgcttttgac ttcttgaacg acttccaaat catttaggtt ttgcaggata 2975821 tcactgaaat cagcttctga tgtatgatgt gtgacaatta cgatttcagc taactcatca 2975881 tggcctttaa ttggcagctg aaggattttt tcaaagctca cgccccgctc tgagaacaca 2975941 gatgtaattt tcgagaatga accaacctca tcttttacat gaattcttaa aaactgctgt 2976001 gcataaatgt cagacggcga tttcatgttt ttctcatatt gcggtccgac aaagctgttg 2976061 ccggttacac ctaggcgcat atttttcatg acagcgacga ggtcagaaac aacggatgtc 2976121 gctgtcggca tgcttccggc tcccggcccg tagaacatcg tctcaccgac agcctcgccg 2976181 tatacataaa cagcgttaaa ctcattatga acagcagaaa gcggatgatg gtcaggaagc 2976241 agtgtcggct gtacgctgac ctcgattttg ctgccgtcac gctgagcaat cccgatcagc 2976301 ttcattgtat agccgaggcg tttgctgaag ctgatgtcct cgtctgtaat ttgggagatc 2976361 ccctttactt tgacgtcttc cagatccacg ttcatcgaga agccgaggcg cgccaatatc 2976421 gccattttcc gtgcggcgtc aagcccttcc acgtcagaag tcggatcagc ttcggcaaaa 2976481 ccgagatcct gcgcttcctt gagcacttcc tcgtatgggc ttttctcttt gatcattttg 2976541 gttaagataa agtttgttgt gccgttcaca attcccatca tttttgtaat tcgatctgat 2976601 gagaggcctt cctctaacgt gcgcagaatc ggaatcccgc cggcaacact ggcttcaaag 2976661 tagatatcgc atccattttc cttcgcttcg gcaagcagct cggagccgta cacagccatt 2976721 aagtccttgt ttgctgtgac aacatgcttt ttcgatctca gcgcgtcgac caaatattgt 2976781 tttgtctgtt caacgccgcc gatcacctcg atgacgacat caacatctgg atcatcaatg 2976841 acatcataca cttctgtcgt gagcacttcc ttcggcaaat ctacttctct ctttttctct 2976901 aaatctttta caagcacttt ttttatcgta accggacagc cgacctgatg cataagctta 2976961 tcctgatggt cttgaataat tttaacgaca ccgcttccga cggtacctaa acctaaaagc 2977021 cctacacgaa tcgctttcaa aaaaactcca cctttctttt gattgtcctc ttggaaaaga 2977081 caattgttaa ctcaacacag acatataagt tacaaacatt atataagccc gctcctgttt 2977141 tgacaagaca tcattaggct gaattttgcg aatgtaaacg cttaacgcat tgatatgaca 2977201 agattcttta ttttctaatt atttttgtca gattttctcc tcaccttgag ctgcctttgc 2977261 cgagccagct gacgcgtgga acaaacagct tctgcgcccg catattcatg aattcctgcg 2977321 ctgtattgag aaattgttca taacgcccac agtcattaag aatgaagtca agctgttctt 2977381 caaaataatg cttttctgat tctgatgaca tgtaatagct ttctacgatt tcaaaataat 2977441 gaagcgggaa aagcagacgg ctgtataaaa ggcgtttcga aaatgaagac agcggtgtga 2977501 cttgctcgta ttcctgtaaa aagagaaagc cctgctgatt aaaatcttgt ctgtgatgca 2977561 aaaacgtatg cctcatatat tcagccaaat cacgggaagc gtggtcaaac acccaatccg 2977621 ccggaatcct gatcaatgat tccggtgacc atgtatgcct ttccatccgc tgatggcata 2977681 tcgttcctga atcagcggct tggggcttgt catccagctc agtgtccact aaatattgta 2977741 tcgcgttttc tgacagtcct aaataatatg gaaatgattc gatcattttt ttatcgaatg 2977801 gctcatgcgg aggggtctga acctttctct gccaaaatgc ttccagctga tcaattcgtt 2977861 ttccccacag atccttccac tggccgattc ttccggccgc cttcacctca tatggatatc 2977921 ctcggccttt tcggtgaaat tccgcaagct ccgctccaat ggagaacgcc ctgtttgaat 2977981 aagggggggc cgccttcagc agagcgtacg tttttccctc atgttcaaat gtcagttcac 2978041 cttcttttgt aaagataaaa accgaaacgt atgggtcact ttgttcttgt aaatactgac 2978101 tcatgtaata aagctccgcc agctctgttt ctgagaattg ggaaacgggg acaatcagaa 2978161 agtatgaatt aggcgtctga aagcattgat atgtgtgctg gtacatggaa agctgcctga 2978221 tgtgaatgcc gtatttttct tttattgtac ctttcaccat gatcacctgc ctgttgaatt 2978281 agggctcatc acatcgtagt catacacagc cggaattatg aatacatatt ttaatccgaa 2978341 gaaggcgcaa gaaaaagtcg taaacttctc aagcattttg tataaactag taaaaaagat 2978401 tgggtgaagc tgatgtcaga aaacgaacaa ttcagtcaga tggaagctaa agcaagagca 2978461 cggatgaagg agcgcggcgt tgaggtatca gacattgccg agcttgtctt ttttctgcag 2978521 aaaaaatatc atccggattt aaccattgat gaatgcacgc tgaacgtcaa tcgtgttctc 2978581 gcaaaacgcg aggtgcaaaa cgcgatttta acgggcattg aattggatgt tcttgctgag 2978641 cagaaaaaat tgtctgaacc gctgcaaacg atgctggaaa tagatgaaag cctatatgga 2978701 gtagatgaag ttctggcatt ttccattgtg aacatttacg gatcgatcgg gtttacgaac 2978761 tacggttaca tcgacaaaga aaaacccgga atccttaaac gattgaatga taaatcaacc 2978821 ggtgaatgcc ataccttttt agatgacatc gtcggagcga tttccgccgc ggcttcaagc 2978881 agacttgctc accgcgcgcg gcatacagaa taagggcacc cttttagggc gccctttttt 2978941 caaatgtatg gaatccattc agtcagagag tcaatggcgt gagtcggttt ttccatatcg 2979001 tctgtcatat gttctctttt cgttacgcct gtgtgaacga gcagcgtatc catacccgcg 2979061 ttaatgccgg ccataatatc agtggcgtag ttgtcgccga ccatgagtgt ttcagacaca 2979121 tctgtgccga gaacgcgcat cgcctgctcc ataataattg attccggctt gccgataaat 2979181 acaggctgta cacctgtaga tacggttaac accgatgtca gtgagccgtt tcccggcagg 2979241 agccctcttt cagtcggaat cgcaatatct ccgttagtgg aaataaagcg ggcgccattt 2979301 ctgattgcca ggcagccaac agcaaatttt tcgtatgtaa tggaacggtc gatgccaaca 2979361 acgacaaaat ccgcgttttc tccgccaaat gtcaggccgt tttcttcaat cgcctggcgg 2979421 attccttcct ccccaatcac atacacagac gcgtcttttt tctgctgtgc aatgtgctgg 2979481 gcagttgcca tgctggtcgt gaagacctgc tcttctgttg ccggaatatc aaaagacacg 2979541 agcttgtccg ctacctgctt cggtgtgcgc gaagagttgt ttgtcacgaa aagataagga 2979601 acgccgcgat ctttcagcgt tctgacaaat tcacacgcct cctcgatttt ttccgtgcca 2979661 ttgtacatcg ttccgtctaa atcaattaaa taccctttat atgttttcat atccaacact 2979721 cctgtggctt tccagttgtt atttaaacgc ggaaacaggt cctagctctg tttccaaata 2979781 gcttctgatc cgtttcggga agtcctgaag agctgtttga tgcgccttga tcagcctgta 2979841 aagctcgccg ctgtcagcga gcagatactg ttgaaccaac gttttgcggt aggcgatcaa 2979901 ttttttgagc tcatcaccct ctttttccgt gacaactttc tcatcaacaa gtatatccat 2979961 aatgtcgtca tagctgcccg ggtcccgcat aataaagccg tcaatcatgt cattgcctgt 2980021 atccaaaatg cattcgatta acagatggcc tatacgctga agtgccaatt ccccgatttc 2980081 agactgccag tctgtttgtg agtcaaatag cgccagctgg tgctcgaaga accctagtgt 2980141 tttttcgatt ttgcttctgt caacaaaata catgacagca tcccctttgt gtatatttat 2980201 tttctgatcc gtttcaagac aaaatacgca cagccgaaat tgcagtattc gtaaatatat 2980261 tcatctaatg tgctgatttt cgtttcgaag gttgcctttt gattctggtc gtcaaagaag 2980321 cccttgagcc ttaactgacc gtatccccag tctcccacaa tataatcgta tttatttaat 2980381 atatcggagt agcgggcttt aaaagcctct tcgttgaagc cgtctttgaa attgtgcacc 2980441 aattcaaatt cggcattttg aataagaatc atgatctcac ctcttttttc actcattcct 2980501 atcataattc attgccccgt ccccatcaat tgctaaagaa taaatcatgc gatttggcta 2980561 ccctacacat gaggagggat tgataaatga aacgaaccgc tgtcagcctc tgcctgctga 2980621 ccggactatt atccgggtgc ggaggcgcag gattggataa tgcccaaaat gtccggaatc 2980681 agacgcagaa tcaaaccaaa cccattcatg tgtcggaccg caacgaggct tttaacaggc 2980741 ataatgagaa cgaacaattt ggctatgtcc gctatcaaaa agaacaattt gacggagaac 2980801 agcagaaaac gccggtgatg aaccgggaag aaaccgctca catgatatca agtttaacgg 2980861 ttcagctccc ccatattcaa gatgctgcga cattggtgac tgaccgagaa gcgcttgtcg 2980921 tatacaaaac cgattctaaa aaccgggagc tgaccgccga tcaggtgaaa aaaacagcgg 2980981 cttctgtgat accgcgatac tatcacgtgt atatttccga taatccaaac catatgcaat 2981041 ccgtcgaaaa ttacagcaat ctcggctctg gttcaaggga tattagagag atcatgtcgg 2981101 ggacgattca agaaatgaaa acctccccgc aaggaagccc tgtctcagag aatgaaaatg 2981161 ccaatggaga aacgcgtcag gacatgaaaa tcgataggaa tgacaaaaac gccagatgat 2981221 ctggcgtttt ggcattatgc ttgtgcttga cgctttttag atgcttcgtt tacttgttca 2981281 tccgcatggt aagaggaacg gacaagcgga ccggcttcac aatggctgaa gcctttttgc 2981341 atcgcgattt cttttaattc tgcaaattca tcaggatggt agtatttttg gactttcaag 2981401 tgtttcttcg tcggctgcag atattggccg attgccataa tatccacgtt gttcgccaag 2981461 aggtcgtcca ttacttcaat aatctcttct tttgtttcgc cgagtccgat catgatactt 2981521 gattttgtcg gaatgtcagg ctgcatttcc ttcgcacggc gcaaaaattc caatgaacgg 2981581 tcgtacgtcg cacgcgcgcg gactcttggc gtcaggcggc gaaccgtttc gatattgtga 2981641 ttcaggatgt ctgggcgtgt atccatcaag gtttttaggt tatcgtagtt tccgcccata 2981701 tcagacggca gcacctcaat tgttgtgaac gggctttttc tgcggatcgc acggacagtt 2981761 tccgcgaaaa tgcctgcccc gccatctttc tgatcgtcac gcgcaacagc cgtaatgacc 2981821 gcgtgtttca aattcataag cgcgactgaa tccgctacgc gttccggctc ttgcagatca 2981881 agctcagttg gaaggcctgt tttgacagca cagaaacggc atgctcttgt acaaacagaa 2981941 cctaaaatca taaatgtcgc tgtacgtctg accgcccagc attcatgaat attcggacac 2982001 tttgcttctt cgcatacggt atgcaggttg ttttcccgca tgagtttttt gagccctgta 2982061 tagttttcat ttgtatttaa tttaatttta agccattcgg gctttctgag gtgttcgtct 2982121 ttctttgcca attcccatca tctccaatat ccaatatact caatttctga cacgaaacat 2982181 tctgaaaacg agaaaggtgc aggttttagt tctgcaacaa aaataatgtt tttctaacta 2982241 aagaaagtct tttctttaga cactttaaca taggaaaaat ttctcgacaa gggaagatga 2982301 ttactgacat ttttaagccg ggttgccgca aactatgtgt attcaatatg aaaggagatt 2982361 attttgtgaa agttttgtta tccgctcttc ttctcctttt gtttgcattt gagccttctg 2982421 cgtctggaaa aaaactttca gatccagtgc tgtcgaaacg gatggaatta tatcataaaa 2982481 tcgaagctgt gacgcagatc ccttggtatg cgctcgccgc tgttgatcaa tacgaagaaa 2982541 acgtgcggag caaccggaaa gatctgcctg aaaaggcggg aatcatcagc atctatatac 2982601 ccgatgatat ctggagcggg cctgaaaacc cgaatccgaa agacgatgcg ccgttaagca 2982661 ttaaagtgtt tgacggaatc ggaatggatg gcgatggaga cgggaaagcc gaggtcagca 2982721 acgatgaaga tatcttgtat acgttcagcc aatacttact gtcgtatggc acagatgaag 2982781 acaacatccg gatcgggctt tggaattatt accggcgtga tcagacagtg gggattatat 2982841 ctgaattcat gaagctgttt aaagcctacg gccatattga tctgggcgag catgcattcc 2982901 cgcttccgat cagaaccgat tacagctacc gaagcacgtg gggagatgcc cgcggcttcg 2982961 gtggaaggcg gattcatgaa ggtacggata tctttgccca ttacggcctt cctgtcaaat 2983021 ccacatgtta cggcgtagtt gaaatgaagg gctggaaccg cttcggagga tggagaatcg 2983081 gcatcaggga cattaacaat acgtatcatt attttgccca tctcaatggg tttgccaaag 2983141 ggattaaaac aggacaaatc gttgagcctg gccaagtgat cggatcagtc ggcagctccg 2983201 gatacggccc gccgggaacc gccgggaagt tcccgccgca tctgcactat ggcatgtaca 2983261 aagataacgg aagaaccgaa tggtcatttg atccataccc gcatttgagg gcgtgggagc 2983321 gatatgaata ccaaaaaaag aagtaacaaa aagccgcctc ttcaacaggc ggcttatttg 2983381 ctgctttttt ctttttttga atcggcaccg ttttctttgc tgctcggaag ctggacagaa 2983441 ggcgtgacac ccgagccgcc gcttccatta taaaactgcg gcacttcgcc ctgcactgct 2983501 ttaatcgata caggaacatt atttgtgacg acagcggttt tgctggcaaa tggaatgatg 2983561 accttcactt taatttcgac aaagatgctg atatcaataa gtgcgttatt tatgccatac 2983621 ggcttgattt tggttttgac atctgtaaaa gcgtcaccga ttaaattgaa ccggaccggg 2983681 attttcggcc cgaggtttcc aagaaggctg ttgccggtta cctgtcccag cggaatgttg 2983741 atcataatgt tttcactggc gccgctgtgt ccggtatggg tttccatctc tttcaaatga 2983801 gcctgaagct gctttgtcac ttttgttttc acactgttta caacctgtgt attaaaatcg 2983861 attgtcgtta agtttccgtt ttcatcagaa ttcatttgaa acatatcttt catattttca 2983921 ctgtcagaca tatagtcctc aatcgaatcc tggatcacct ctgtcgctat acgcttcgtt 2983981 tccatctcgc cgatgtccat taaaacaggt ttgatcgagc cattgatcat ccaaaggctg 2984041 accgttgttg acaggataaa aaagacaacg gacaggagca tcacgtaacg gaaaggcaaa 2984101 ggtcctctct tgcgaaaagg gccgcgatat cttggcaaga aaatcccccc ttacatatca 2984161 caatgtatgc ttgtaagagg ggacatagta atagccgggg ccaatttatt ttatttcatc 2984221 atttttaaaa gcgcttctct gccgctcatg ccgactttga tgccaagatc ttccgcagcg 2984281 tacgtgacgg attctaaagg tgcgtctaac agctggtcaa tggtgcggac accaactgcg 2984341 cgtcccgcca cgatgccgcg ctcctttaat ttttcattca gcagcgccac atcaagcgcg 2984401 ccgcacataa tgtatccgtg atcattggcg acggccataa aattcgtttt gggaagcttt 2984461 actgtcacag ctgtaaaagg ctgtccttct atcatgatcg gtgtcaggtt taccacgtca 2984521 accactccct tcattcatca ctttatgatg aagggcacag cttgttgtgg gctgactgcc 2984581 ttattgtgca agcttccaag caagcagatc ccgcaaaaat tccggcataa aatattcttt 2984641 ttctgcagcg tcgcgaatca acggaaacag tttgccgagc gtaaacatat caagcaccgc 2984701 aacggagtat tgtttatgtt tttcaatatc ttccccgttc agtgtgatcc gagtgacgtg 2984761 ggtgatcccg tcatcgagcc gtttcgtttc tacctcaacg ccggcataca ccattttccc 2984821 catcacttct ccgcggaagc cgagtccttt gatccggagc tgctccattt gttcggaagc 2984881 ggcatggaca atggtttcct tcagttcttc tcccgtcagg cggacagcca ccgggttgat 2984941 cggatgcgga cagatgcggt gcagatccag ctttgtcaca ggacctgctt ttagcggacc 2985001 gagaatgaca cctgaattga ccatactgat gtccgtctcg caccattcct ttaaggcgta 2985061 tgccaaaagc aaaggcagct ctgattcttc aaaccacttc acctcagcat cttgtgcaag 2985121 ctctgcaacg gcatcggaca gtttctcctc ggcttcacgt tctttttcat tgagaaacgc 2985181 tttagtttct gcggattctc ctgtccattc cgccatgttc tgcacagaag ccgttttgct 2985241 gttgatgctt cgctgtacgc tgtccaccgt gatttctaca cagccgacat aatgcccgta 2985301 tttctcggcg ctggccagca gtaccccatt aaccacttgt ccatcttcga gcaaatgatg 2985361 ggtatgtgat tcgaggatta catcaatctc aggcaccgct tcagccactg cttgatcatc 2985421 aagaatgcct aaatgtgaca gcagaacgat aatatcagcc tgccctttca cttccagaat 2985481 ggtttccttt atgctttcaa gggcatccgt aactgtccat cccagcttgt catatacagg 2985541 ataatacggc acagttacac ctaagaaagc aatggacata ccgtttttca atgatttgat 2985601 atggtaaggc accgcccagg acggacggtt tccattttta tcaaacaggt tagagacgat 2985661 gacaggaaat tcagcatgat catataaggc agcaagctct tcatgcggaa gcgtaatccc 2985721 ttcgttattg ccgatcgccg ctccatcaat gtgaaggcgg tttaagagat cgacattcgc 2985781 ttttccgaat gtcgcctctg tcacgaattg aaaacgatca agatgatcgc caatatcaaa 2985841 aacgagcgtc tcttcgccgt ctgactgatg ctcttttctt ttctgctcga tataatctac 2985901 aattttcggc cagttttcaa aatggctgtg caaatcattt gtatgatata agcggagctt 2985961 ctccttcata atatctctcc ctaatcgttc agctgaaaat gccttcataa atgagctggc 2986021 agccgatcaa aatcaatacg atccgcatga tcataacgat cgttttcgtc tgcatttttc 2986081 tgttgatggc ggcgccaagc tttccgccga accaagcgcc gggcacaagc gcgagggcgt 2986141 acagccaatt gacgtgcccg gaaatcatat gtgaaacaga ccctgtcata gaagacagga 2986201 aaataataaa catggacgtt gccaccgcaa ccttcggcgg aaacagaaat aacagcatca 2986261 tcgccggaac catcagtgat ccgccgccta taccgaaaag tccgcctaaa aaaccgacaa 2986321 caaaggcaat ggcaataccg acagaggcct gatatgagta cgtataaggc tcaccggcat 2986381 catcctgaaa tgtccggata attcctttgt gcgctttgtt gattggccgg gctttcgctt 2986441 tcagcattaa ggataatgaa atcagaatca taaaaatgcc aaaccaaacg gaaaacgagt 2986501 ttgaattgaa cagctttgac acgtaagccc cgatcatgct gccgggaccc gaaccgataa 2986561 agaaaatgag tccgctctta taatcaactg ttttatattt aatataagcc aaagttgaag 2986621 aaaggcccgt aaaaataatg accaaaagcg aagttccaat cgcaacctgc ggcgtcacat 2986681 cctgaaacag ctgcgtcact gtgcttaaaa acatcagaga tggcacaatg acaattccgc 2986741 cgccaagccc gatcagactt cctaccgtac ctgcgattaa tcccagtacg accaaaatca 2986801 caaacgacat caatcaaaac ctcttttcta aaataaatcg agctgtctcg gagcaagtcc 2986861 gctgtactcg atatcaagca gttcaagcat ctgcttgcca ttatccgcag cgtcaccgcc 2986921 ggaattgttg ttgaacagga caaaaacatc cttacattgc tgctgcaatt cattcaggtg 2986981 ctttttccaa tcctccagct cctgttggtt gtagcggtat aagtacctga cctcccgcca 2987041 gtttttcccg ccatcaggct tcatccagcc ctgcttgttg cgtccgtgaa acctgacgag 2987101 cgttttgttt tcatcggtcg cgcgcaacac ggtcggaacg ctgccttctc cgatttgcgg 2987161 ttcatcacag acactgtgaa tccagccttc cgctttcata aatgaaagcg tctgctcata 2987221 aaatggcggc gagaaccagg aacggtttct gaattcaagc gcgcaaggaa tatctcccat 2987281 ttggtgctta caccatctca aataggcgac attctccttc ttgcagtcaa accacggcgg 2987341 aaattgaaac agcaccatgg cgagcttatt gctatgtaaa tatggcgtta aagacacctt 2987401 aaacgcatca aacatctcct cttttgagtc aaagggaatt tcgccgcgct gatgccctgt 2987461 catgccctga tatgctttca cgataaattg gaaggtttcg ggcgtttcct tcacccactt 2987521 ttcattattg cgcgccggct gaatcgcgta aaagctcgcg tctaattcca cgatcggaaa 2987581 atgggaggaa taggcctgca attttttctg gctggccgtt ttcggcggat agatgctgtc 2987641 atgatccccc catcccgtca gtccgatata aatcacactc attcacctct cttccagttt 2987701 atcacacgtg ttttcaggtt tcctcggaaa tgctgttcat atggcgggaa aatgcctcac 2987761 gcaaatgctg atattgttcc tcattcgtat ctaaaaacgc ctcttctctt gaggaaggaa 2987821 tgtgctgata ttcaataggc gcctgaaact gctcactcgt aaaatcgtac accacaccat 2987881 tgatgctgtt ataaaaatgc cagctctcat cgactcttgt tttgaaaatc gtgccgccga 2987941 aatggtcttg aatcaccaat gccgtcacgc cgcattggcc gcatgacggg cattcttccg 2988001 tccatttaga gctcgaatgg cgcgaccagg attgcttaag tatgtatttg acatgctcca 2988061 ttgcctccgc ctcctttaaa aaaagatacc acgttgatga gattttaaaa actagaacgg 2988121 aggaaatcaa aaaacccggc ggtaaaatcc gccgggctta cgaaggaacg accagagctc 2988181 cgtcaatttc agtgactttt tccccatcat tgtacacgca ccggcctttg ctgtaagtgg 2988241 ccgaaatgct gcagggaaat gtatgtcctt cgtaaatgct ttttttatgc tttgcaaaca 2988301 tcgattctct tgtaacagtg tacggctcca tgctgacgag cacgaaatct gcatcacacc 2988361 ccgcctcaag ccgccctttt ttctgaaggc cgaatcgttt tgcaggggcc gccgctgtcc 2988421 attctgcgat ggtttcaaat ggaatctgat gctcaagcgc cagttccagc attcctaata 2988481 aagtgaactg cccgccgctg attccgcccc atgataaaaa catgttatcc tcccgcttca 2988541 aggatggacg gcaaggggaa tggtctgagg aaaccatgtc aatgtccccg gcaatgagcg 2988601 tctcgatcag cgtctctttt gattgccgtg accggagcgg aggcgcgcat tttgcgacag 2988661 agcccctttg ccgtaaatcg tcatggctga acaagacata atgcggacat gtttcaaccg 2988721 aaacatcaag accttcctgt ttcgcctctc tgatcagccg gaccgctttc gccgtgctga 2988781 tatggacaaa atgaaccgga cagcctgtca ccttcgcata ctgaatcgtg cgatacaccg 2988841 cttcaacttc tgcttcctcc gggcgggagg cggcgtacgc atccgcatcc acctttcctt 2988901 tattggccaa aaccatctgc aagtagcttg tgatcgcgtc gctttccgcg tggagagcga 2988961 ggatttttcc tgcagccgcg atttctgcca tgcctttgag caatgtccgt tcatcaacag 2989021 agcggaactc atcagtgcct gactttgata aaaacgcttt aaacccgatc gctcccgctt 2989081 cagccatcgg acggatgtcc tcgatatggc ctggcacaag gccgccccat agcgcaaaat 2989141 ccacggcaga tttttgcctg cctagctcag cttttgcgag aagatgctct gccgtcacgg 2989201 ttgatggaat acagttgagc ggcatatcaa aataggtagt gcaaccgcct gcggccatca 2989261 tttgagaacc tgtttcaaac ccctcccaat cctccctgcc cggttcatta aaatgaacat 2989321 ggcaatctat cacaccagga aacacgtatt tcccgtctgc ctggatgatt tccgtcccgc 2989381 ttgcttcaat gtcagaacct atctcggcaa tgacaccgtt ttgaactaca atatcagctt 2989441 ctataacgcc atctggcgta actgccttcg caccttttat caccatatcg taagccatat 2989501 tgatcccccc atgtcaggat gacgattttc catgtcagtt tatgtaacac aaccagttct 2989561 attttcaaca gtttactgct actatgatcg tattacatca gcaaaaccgc tagaattcct 2989621 attgaaaatt attcacctta accaatgttt ttatagaaaa ggagaatgcg ctatgaatat 2989681 tcttgatgtg atgaaaatac cggcttttga aaacgccaat ttaatcgctg gaaaagcagg 2989741 aggggaaaga gaggttcagc atgtcaatat gatggacgct ccggatatcg tagacttttt 2989801 gcataagaat gaattgctcg tcaccaccgc ctatcacctg aaggatcacc cgcatcaatt 2989861 atctgaactg attcggcaaa tggcaaaacg cggctgcgcg ggcctcggca ttaaaacaaa 2989921 gcgctatctg gaagatatcc cgaaggaaat catcgaactg gccgattcat atgcgtttcc 2989981 gatcattgag cttccggaac acatccgact cggcgatatt gtgaatgcca cactcagcca 2990041 tattctcgat atgcgttcta acgagctgca gcaagccatt tacgcgcaca aaaaattcac 2990101 aaaccacatt atgagcggca aggggctgca atccctcctc aaaaaggtgt cagacatcct 2990161 tcagcttccc gtgctgctgc ttgaccagca tgccaaaatg ctgtctgcgt ctcatcagat 2990221 ttcagttgag accgaaaagc tgaaaggcac cctgaatacc gtatccgggc catttttcac 2990281 ttgtttctct acaatctcag atcagaaaac atattctgtc ctgcctattt ataatcacga 2990341 aaaaaactgc ggctacctgc tgatacccga catggtgcag gcaggcgaca aaggattgat 2990401 cctcacgatt gaacaagcgg ccaacgtcat ttcctttgaa ctgctgaagg aaaatgcgct 2990461 gaagcagttc agccggcggg cccgcaatga gtttttcaac aattttattg agcggacctt 2990521 ttcttcagat gacgaaatca aaaaccgggc gaaagaattc aagctgcgct gggatcaaaa 2990581 atacatgtgc atcgccggca aactcgatcg caatgacgaa tcaatcagct ttacagaaaa 2990641 tcagctcgct tccgacagcg tattcgaatt tcttgaaggt gaattatcag ccttcccgtt 2990701 tccacctcac ttctttatga aaggaaatgt cggcattatt ctaatcgagg cgacagacag 2990761 ctggagtgaa atgcacgcct cggtgatcag ctttttagaa cagtttcaaa cacaggtcag 2990821 cgctcaattt aaacgaaccg tgtcctttgg catcagcaat atctgccaaa agctcattga 2990881 tgttcccgac gctttcacag aagcttctga tgctctgcaa tcggggcatt tgtcaagaag 2990941 caccgcattt atccaggtgt atcacgccaa agatgtgcct gagcttctgc gcttgctccc 2991001 agttgaggat ttgaagaaat tttacaactc cacgcttcag agcctcgctg aaaaacagca 2991061 ggaggatcaa agcctgcttc atacgctttc cgtctattta gagacacact gccaaatttc 2991121 agagacggca aagcgtctgt acgttcatcg caatacggtc atataccgcc ttgaaaaatg 2991181 cgaagagctt ctggggaaaa gcttaaaaga tcctgaaaca acgatgcgtt tgcggcttgc 2991241 attacgtatg cagcggctga tcagctaaag tttgttacat tttcttacaa aacgaatcgt 2991301 ttttcgtcac tttcagcaat cacacctgtc tttttcagct actgtatcca atgacacccc 2991361 tcgaccggaa cgatattatg ttactaaagt tcacatacag ggagggacta tagtgaaaaa 2991421 aagatcgttt aaggtgttta cacttagcct gcagcatgtg ctcgccatgt atgcaggtgc 2991481 gattttggtg cccctgcttg tcggcagggc gctgaatgta acaactgaac agctgtccta 2991541 cctattggcg attgacctgt taacatgcgg cgtcgctacg cttttgcaaa ccttgcgcgg 2991601 aacatacatc ggcatcgggc ttcccgtcat gcttggcagt tcatttgtgg ccgtcacccc 2991661 aatgattgca atcggcagca attacggcat tcacgcgatt tatggttcca tcattgcggc 2991721 cggtgtgttc atctttttgt ttgcgcgttt tttcggcaag ctgactgtgt tatttcctcc 2991781 tgtcgtaaca ggtaccgttg tgaccttgat cggcctttca cttgttccga caggtgtgaa 2991841 aaatatggct ggcggcgaaa aaataaacgg cagcgccaac cccgaatacg gttcgctcga 2991901 aaaccttctt ctctctgtcg gtgtccttgt tctgatctta gtcctcaacc gctttctcaa 2991961 aggatttgcc cgaacactgt ccgttctgat cggcatcgcc gccggaacag cggcagcagc 2992021 gatcatgggc aaagtcagct tttcttctgt tacagaagca ccgttcttcc aaatcccgaa 2992081 gcctttttac ttcggagccc ctgcgtttga aatcggtccg atcttaacga tgctgatcgt 2992141 cggaatcgtc attattgtgg aatcaaccgg cgttttttac gcaatcggaa agatatgcgg 2992201 cagaccttta actgacaaag atctcgtcaa aggctatcga gcggaaggaa tcgccattct 2992261 catcggcggg ctgttcaatg cctttcctta taataccttt gcgcaaaacg ccggcttatt 2992321 gcagctgacc aaagtgaaaa caagaaacat cgtcgttacc gcaggctgta tccttgtctg 2992381 tctcggactg attccgaaga ttgccgccct tgcatctgcc gttcctgctg ctgtacttgg 2992441 cggcgcgacc gtcgtcatgt tcggcatggt gattgcctcc ggcgtcaaaa tgctcagcac 2992501 agcggatctc aaaaatcaat accacctcct gaccatcgca tgctcaatcg cactcggcat 2992561 cggcgccagc acggcccccg ggatttttgc tgaattcccc gctccgatcc ggattctggt 2992621 cagtgacggc accatcaccg gaagcctaac cgccatcttt ttgaatctat ttttcagctt 2992681 gcgcgacaaa aaagaattaa cagcacagca aacagaactt ccggtattag aacatacact 2992741 cgcattagaa aaagaggtgt aaaaaagatg aaggaacagc acaatgcctt acagctaatg 2992801 atgctggggc ttcagcacat gcttgccatg tatgcgggag ccattctcgt tccgttgatc 2992861 gtcggagcag cgatcgggct gaatgcgggg cagctgacgt atttaatcgc gattgatttg 2992921 tttatgtgcg gggcggcaac tcttttgcag ctctggagaa accgatattt cggcatcggc 2992981 cttcccgttg tgctcggatg cacgtttacc gcagtcggcc cgatgatttc catcggaagc 2993041 acttacggtg tcccagcgat atatggtgcc attatcgccg caggactgat tgtcgtctta 2993101 gccgcgggct tcttcgggaa gcttgtccgt ttttttccgc ctgtcgtaac cggatcagtc 2993161 gtcatgatca tcggcatcag cctgattcca acggcaatga ataacctggc cggaggtgaa 2993221 ggaagcaaag aattcggctc actcgacaac gtgctcctcg ggtttggcgt cacagctttt 2993281 atcttattgc tgttttattt ctttaaaggc tttatccgct ccatagcgat tttactcggt 2993341 cttatcgcag gaacagcggc tgcatatttc atgggaaagg tcgatttttc tgaggttttg 2993401 gaggcgtctt ggcttcatgt tccgtctctg ttttatttcg gaccgccaac ctttgagctg 2993461 ccggctgttg tcacgatgct tctcgttgca attgtcagcc tcgttgaatc gacaggcgtt 2993521 tattttgccc tcgctgatat cacaaaccgc aggctgtcgg agaaggatct ggaaaaaggc 2993581 taccgggcag aaggccttgc gattttgctg ggcggcttat ttaacgcgtt tccctataca 2993641 gctttctcgc agaatgtcgg catcgttcag ctctcaaaga tgaaaagtgt caacgtcatc 2993701 gccatcacag gaatcatact ggtcgcgatc gggctggttc caaaagcagc ggccctgaca 2993761 acagtgatcc ccaccccagt tctcggcggc gcaatgatcg tcatgttcgg catggtcatt 2993821 tcttacggga tcaaaatgct atccagcgtt gaccttgatt cgcaaggcaa cctgctgatt 2993881 atcgcctctt ccgtcagctt ggggcttggc gctacaacag ttcccgcgtt gttttcatct 2993941 ctttcgggcg cggcctctgt cttggcagga agcggaattg tgatcggcag tttgacggcc 2994001 attgcactgc acgctttttt tcaaaccaaa cagccgaata gcgcagacat aaaaacgtaa 2994061 aggaagatgc caatgttcac aatggatgac ctgaaccaaa tggacacaca aacactgaca 2994121 gacacacttg gctctatttt tgaacactct tcatggattg cggagagatc cgcagcacta 2994181 cggccgtttt cgtccctttc tgatcttcac cgcaaaatga ctggcattgt aaaagctgcg 2994241 gatcgcgaga cacagcttga tttaatcaaa aagcatcccc ggctcggaac aaagaaaaca 2994301 atgagcgatg actcggtacg agagcagcag aacgcagggc tcggcaaatt agaacagcag 2994361 gaatacgagg agtttctcat gctgaatgaa cactattatg atcgcttcgg ctttcctttt 2994421 attttagcgg tgaagggaaa gacgaaacag gacattcacc aagccctgct ggcaaggctt 2994481 gagagcgaac gagaaacgga gttccagcag gcccttatag aaatttaccg aatcgcccgc 2994541 tttcgtctgg ctgacatcat cactgaaaaa ggagagacgc aaatgaaaag aaccatgtct 2994601 tatggcaaag gaaatgtatt tgcataccga acgtatttaa aaccgctcac tggagtgaag 2994661 caaatcccgg aatcatcttt tgccggaaga gataataccg ttgtcggcgt tgatgtgaca 2994721 tgcgaaattg gcggagaagc cttcctgcca tcatttacag acggagacaa cactctcgtc 2994781 gtggcaacgg attcaatgaa aaactttatc cagcgccatc tcgcatccta tgaaggaacg 2994841 acaaccgagg ggttcctaca ctatgtagct caccgatttt tagataccta ttctcatatg 2994901 gacacgatca ctctgactgg cgaagacatt ccgtttgaag caatgcctgc atacgaggag 2994961 aaagagctca gcacaagccg cctcgtcttc agaagatcgc gtaatgaacg aagccgctct 2995021 gtgctgaaag cagaacgaag cgggaatacc ataacgatta cagagcaata cagcgaaatc 2995081 atggatcttc agctcgtcaa ggtgagcggc aactccttcg tcggcttcat ccgggacgaa 2995141 tatacgactc tcccggaaga cggcaaccgc ccgctgtttg tctatttaaa catcagctgg 2995201 caatatgaaa atacaaatga ctcatacgct tctgatccag cacgctacgt tgcggctgaa 2995261 caagtccgcg acttagcgag caccgttttt cacgagctcg aaaccccttc aatccaaaac 2995321 ctaatctatc atatcggctg cagaatatta gcgaggttcc cgcagctcac tgatgtcagc 2995381 ttccaatctc aaaatcacac gtgggatacg gttgtcgaag aaatcccggg ctcaaaagga 2995441 aaagtctaca ccgaaccgcg cccgccatac ggtttccaac attttaccgt gacaagagaa 2995501 gacgccgaga aagaaaaaca gaaagccgct gaaaaatgtc ggagcctgaa agcctgatgg 2995561 gaaaactgac aacccatatt ttagatttaa cctgcggcaa accagcggcg aacgtaaaaa 2995621 ttggattgaa gcggctgggc gaaagtatta tgaaagaggt atacactaac aatgacggca 2995681 gggtcgatgt ccctctgctg gctggtgaag agctgatgtc aggagagtat gtgatggaat 2995741 ttcatgcagg agactatttt gcgagtaaaa acatgaacgc agccgatcag ccgtttttaa 2995801 ccatcgtcac cgtccgtttt cagctagcag atccagatgc acattatcat atcccgctct 2995861 tgctgtcgcc gtttggttat caggtgtata gggggagtta agaaggaagc ccgcctcacc 2995921 ggcgggcttc tttttgcact tcaattaact tttgatccta ggacagtact tgaagtgatc 2995981 cccacactta gtgaaacaac agctagaata aacattcacc tatatttttc aggataattg 2996041 cctacgagaa aaataccctg tagtcctttc atttataaat cgaggtttca aactaataag 2996101 tcagctctta gcagccgagc tcccttctcc aatcctataa acagaccgcg ttttttctcg 2996161 aaaaaatact ctgaagacaa ttgctgcgtt tttaatagtt ttgataacgc gttctctctt 2996221 acacctttag acaaaatatt cattttttct tttttagact taaatctatg tcgaaaataa 2996281 tcgttggcat atcttatcct atctccacta aaggaggtga cattatggga ttctacaatt 2996341 ctggtggata cagtggaaac tctggttact caaacggttt cgggagctcc ttcgctttga 2996401 tcgtggtgct attcattttg ttgatcattg ttggagcagc tatctttaat tattaagttt 2996461 aactttcctt gcctccgccg tatccaacac ctccctgtcc gacagacgcc ataagaagtt 2996521 tttatggcgt ctttgctatg tgttcactaa tctttttgta atccagaagc tgtcaagttc 2996581 tacgagattt atcgtgtgtt ttcccacaac gcttctgcgt cttgatcgcg ctgtctgact 2996641 gaggctaaaa aagtccggct tttaaaagcc ggactcccgt ctacccccgt tcaactctct 2996701 tctaatcctg caagctgacc gcataatccc gccatacccg gtacaccggc acaaattccc 2996761 cgccagccct tcttctatat ctttgtcaga aggttgaggg gtttcccgaa acaatgcttt 2996821 aagcgcaatg atcattcccg gcgtacagta gccgcattgg aagccgcctt cttccaggaa 2996881 agcggtttga cacatatcca gctcttcttt ttgaagcccc tcgatggttg tgatggaatg 2996941 gccgtctgct tgataggcca tcgtcatgca cgcattggcc agttttccgt cgattaaaat 2997001 agagcaggct ccgcagcggc cgattccgca ggacaccttt gtcccggtca gctgaaattc 2997061 ctttctaagc aggtcactca gatgtgtcgt aggaacggca gcaacctccc acgcctgacc 2997121 attcacggtc atccggaact gttccttttt tacaggaaat ggcccggcct cttttatgtc 2997181 cattgcttca gcccctttct gtcgatcgct tcaagcaact cttctcttga aattggcagc 2997241 ttgtttatcc agcatccgac cgcatcatgt actgccttta caatcgccgg agtgatggcg 2997301 attgttccga tttcaccaac accgcgcggt ccatatacgt ctcccttcat taagtcttct 2997361 attgcaatca gcttcatgtc aggaacatct ttgattccgg gaatcaaata gtgatcgaga 2997421 ttttccgcag cataacggcc atccgtcatt ttcgcttcct ccatcagtgt gtagccgagt 2997481 gccatggcag cgccgccttc aatttgacct cgatatccct gcggactgac aaccggacct 2997541 gccgcaatag cgtgctcaca atctatcaat ttgacatcgc ctgttaacag atctacctcc 2997601 acctcaacgg cagccgctcc aaatgagtag aggaaatggc cgcccaccac aggatcaggc 2997661 gttgttggaa agtcaaaggc cgtttcctct gccaaagggc ctttttcagc cagctcctta 2997721 tacgtcacca cgagcgcctt tgtgtttttg tcacgcaagc ctgcagcgcc gggaataaga 2997781 ttttccgctg aacagccgct ccattctgcc gcccgttttt tcaactgagc tagaaacggc 2997841 ttcttcaaac gctggatcgc gtgccacacc atgcttgtgc cgcgggatgc tgtggaggag 2997901 cctgacttcg gcacttttgc ggtatcccca ataacaatgg aaatatcctc tgcggcacaa 2997961 cccagctcct ccatgacaat ctgttcaatc gctgctagaa tcccctgtcc gcattcttca 2998021 aatccaaacg aagcagtgat tttgccttca ctcgaaagag acaaacggcc tcctgccgca 2998081 tccattcggc caaaccccag cccgccgccg tgcattgtaa ttgccgctcc cgtgcctctt 2998141 tgcagatacc cgcagttccg gcttgttttt ttaagaatgg gagatttaga tatggcattc 2998201 aacacctgtg ccgctccgtc agttggtgca attcgatgct caagcggccc caagtcatgc 2998261 ggttttctga tattttttct tctcagctcg agcgggtcga tgccaagcat gccgctgaga 2998321 cgatcgagat gggtttcgag tgcaaatgtg atttggttgc cgccaaagcc ccgaaattcc 2998381 cccgccaccc cgttgttcgt aaatactgat attccttcag tccggatatt cggaatacgg 2998441 tacggccccg cggcatgctc gacagaaaaa tcaagaacag ccggtccgag cgtagcgtaa 2998501 gcgcctgtgt ccgccacaat tttcacgtcg tgcgccaata gatttcccga atgatctgca 2998561 cccgttttta tcgtaatctt catcggatgg cgcttaatgc cagaacgtac agattccttt 2998621 cgtgtctgat gaattttgac agggcgtccg cttttcaggg ccaaaagcgc agcatacggc 2998681 tgaatattca gctcatcctt ccctccgaac gagccgccca tcggacttga cacaattctg 2998741 atcttctctt caggaatatc aaaaatacgg gcaagctgga aacggtcttt atagccgtgc 2998801 tgggttcctg catacatcgt aaaacccccg tcgtcttccg gaacggctac acctccctcc 2998861 gtttccatat acgtatgcat ctgccgcggc agctcatagg tttcttcaaa gactgtgtca 2998921 gatgcttgaa acccttcttc cacatcaccg tttgaaaaaa atgcgcggtg caggatattc 2998981 ccgtcctcat gcagtctttg cgcattcggc cgaagcgctt tttctggtga atccatgact 2999041 tccagctctt tatactcaac ttgaatcagc tccagcgccg cttccgcgat ttcttccgtt 2999101 tccgcagcaa ctgcggcgat cgcatccccg acataccgca ccctgtcctc acataaaacc 2999161 ggctgatcag ggatgacaat gccaaatcgg tttaagccgg gaacgtcttt atgtgtgacg 2999221 acggcctgca cgccttccat tttctcagct tttatggtgc aaaccgacac aatctctgca 2999281 tgaggataag cacttctcag caccttgcca tacagcattc ctggaaagct gagatcggtc 2999341 atatatttca attcccctgt gaccttaccc cttccatccg gcctgactct tgacggtttg 2999401 ttgatgatca tttattcccc tccctcagcc atcagctctg ccatgatgac gttggcagcg 2999461 gctttttttc tgtatgccgc tgacataaaa acatctgagg aaaacggcag ctcatggata 2999521 agtgttttgt acagctcatg cgggtcccac cctggtgcca tccatttcgc ttcgctgtcc 2999581 aataatctcc taggagtgat atcggcatgg ccagcggcga ggcgaatgct gccgtctttc 2999641 aaaaaacgtc cagctgcaac agcagccgct ccggtaaaag cctggcgcct tccaagcttg 2999701 tgataaaata cacgctctcc ctccgcccgc gggatgatga cacgcgtgac gatagccgtt 2999761 ctaaagtctt cctcactgag ccaagcgcca agcggcagcc tgattagctc cttttgatat 2999821 acgataagct cagcaccaag cacaagcaga agcggaatga aatcaccgat tttactcgct 2999881 atgttgccgc caatcgtggc acggctgcga atccccggtg cagcgacagc ggaagcagcg 2999941 tcactgaaac agctaagcgc tctcttaatc aaagggttct ttctgcattc attcagtgat 3000001 gtgagccccc cgatcgacac gtgggtgtca ctggtgctga tccctcgcat ttcgtcaatc 3000061 ccttcaaggc tgacaaggtg ctgtttcggt agagttcctt tgtcccactg aagctgaagg 3000121 agcgtgcttc ccgatgcggc acacacatcc ggagcaagct tctctaaaag cgaataggcc 3000181 tcatcaagcg ctgccggtct ccataattga atattcatcc ttgcttttgt cacttggccg 3000241 ttcaagacat cgccctcctt accatgtcat attcctcggg tgtatcaata tcgtccaact 3000301 caccgctatc ctttgcctcc aaaaccgctc ctgctccaag ctgtccgctt ttcaggagcc 3000361 tgcgagcccc ttcatctccc tttaatccct ttacataagg aaaacatgtc gacgagaagt 3000421 agattggcgg ggtgaacgcc cctaaaaacg atgacacggc aaatgactca ggagccagag 3000481 ccacaagggc attgagatga tcgacggaaa gctgaggctg gtcggctaac aaaatgacaa 3000541 tgccgtccgc ccccatgctt tctgcttttc tcaccccgct gctgactgaa tgcccctgac 3000601 ccttttctgc gtcttggcaa acgtgcaggc tccagcgttt ttgaaaaggc ggagcgtgat 3000661 acggcgctcc tatccactca agggaggcat gttctgtccg ctcgacgacc agcacgtgat 3000721 caaggcggga cgacagagca gttttcaagg aaagtgagcc tatgttttct ccttttagcg 3000781 gcaaagccag cttgttttgt cccattcttc tgcttttgcc ggcagcgaga aacacgccga 3000841 tcagataggg gcttctcata caaccgccac ccgttttctt gtttgaatga tttctgcaac 3000901 tacacttacc gcaatttcct cgggaccttc cgcaccgatt ttcagcccga ccggactgta 3000961 aaagtgagac ggaggatgtt ttccgctcag cagccgtttc gtgcggtttg ccgaacccaa 3001021 cagtccaata taatggaggt tttgagaaaa taagaagttg atgatcgttt gatcgtgctg 3001081 ataatgatgg gttgccacaa cagctgcatc atgcggaaaa aattgaaatt cgctaagcat 3001141 ttgttccgga aaagcggtga tcagctgatc cgcttttgga aaaagagagg atgtacaata 3001201 agcgggccgc caatccgtca cgataacaga aaaccctgtg tcagccgcca aattggccag 3001261 cggtacatta tccggtcccg ccccaaacag aatgagacgc ggcttcggtt caattcgctg 3001321 aataaacatg ttagtggttt gatcgaaatg cggtaaatga agcgttgaaa cagtacgttg 3001381 aatatcttgc agaggcgcgt ccggccagtt cccaaaatgt ccgttctccg tcagaaataa 3001441 ataatgggag gattcaatct ttataacgga agtgacagct ttgcctgaat gaaggcagtc 3001501 cctcactttc tcatagtgcc gccttttttc ctgagtgatt cgctctgcat gaacatgaat 3001561 aatgccattg cacccggctc ccatgcccca agaaagatcg tcctccgacc gcatgtcgta 3001621 gggaatcagc gttgatgtga gctgatcgcc cagcgcactg attctttgga atacatcttc 3001681 ttccacacac ccgccgctca gcaagccaat ccgtctgcct tttttcttaa agagcataga 3001741 ggcgcctgct tttcgatacg cggagccttc aacttgaaca attgtcgcca gtacagcctc 3001801 ctcctggtct tccaggagcg catctaacat cgtgtgaaaa ttccccaatg ccgcatcctc 3001861 ctctcgaaaa ttgccgtgag aaacaactag ttcagcgtga ttttataggt aacttgtata 3001921 aagaatagac gatggaagaa aaaatgactc atgatttgtc agaaaatgaa acacatagaa 3001981 agaggatttg taaaaagagt caaacgaaga aaatcagatt ggagaaaaca cgaaatcata 3002041 tcgttaaaaa gcttgcggag ttccgcaagc ttttctttac accgctgcct ggcggccagc 3002101 gttttcatac acatccagcg ctgcttggag cgcttttcct gcttcgattc ctgcgttatg 3002161 tctgagaagc acagcctcta acccggcaag cacgaatagc acgttttctt ttctgcagct 3002221 gtaccccatc gtgccgatcc tccagatctt ccctgcaagc gggccgaatg agctggcgat 3002281 ttcaatgccg aattgtgcca gcagcatgtc acggacagac tcgccgtcaa tgccgccggg 3002341 aatttcgaca caggtgacaa caggcatttt gcagctgtca tctccaaaca atcttagccc 3002401 cattgccttt atccctgctg ctaatgcggc ttcatggtgc cgatgccgct cgaaacgcgt 3002461 ctcaagacct tcttcaagca ccagtctgac tccctcacgt aaggcgtaca gcatcgtcgt 3002521 cgcttctgta tgatgattga gccgtctttc gctccaataa tcctcaagct ggctcaaatc 3002581 aaagtagttg cttgtaattg gccgatttcc cgaaagtgct gccctgtcag cttgtgtcgc 3002641 aatcccgcgt tccacctttt tgcgagctgc aatcacgtcc gccacccgct cattatatgt 3002701 aatcggcgcc attcctgaag gcacagacaa acatttttgc gttccgccga tggcagcgtc 3002761 aatcttccat tcatcgactt taacctcgca gcccccaatc gttgcgactg catcgacgat 3002821 aaacaatgca tcctcggtgc ggcaggcttc gccgatggct ttcagcgggt gaatccgtcc 3002881 tgtcgatgtt tctccatgca ccatggccac aattttcggc ttcacttttt ttatctcccg 3002941 tatgatgtcc tccgggtcaa aaaccgttcc ccattcgcac tccagcatat gaacatttgc 3003001 cccatatcgc tcggcgattt cagtcagcaa ataaccgaaa cggccgtaaa tgggaatgag 3003061 cacatcatct tccggctcta tcacactagc cagcactgct tcaattcccg cccgtgaagt 3003121 gccgtcaatc gggtatgccc agcggttttt tgtttggaac agctcccgaa gcatctccat 3003181 cgtttcattc ataatacctg taaacgccgg atcaaattgg ccgacaaccg gggtgctcat 3003241 tactcttaat acacgcggat caacctcaac aggccccggt gtcataatcg ttcttaacgg 3003301 ggtgcataat tctcttctgc ctgacacagc cattcctcct ttatcagtaa gccagtttgt 3003361 ataataaatc agtcagtgcg cggacgccga tctcaagctg tctggctgac gtatattcct 3003421 tcggtgagtg gctgacgccg cctcggctcg gcacaaacag catacaagca ggatagcgcc 3003481 ttccgatcat ttgcgcgtca tgccctgctc cgctcaccat ttcctcacag ctgaagccgt 3003541 tttctaatgc tgtttcaaaa gccgcagcct tcagcctttc gtccatcggc acaggctcta 3003601 tccgcatata ttcatcaatc acagcgcgaa ttcctttttg taggcaaatg ccgttgatca 3003661 aagcaaccat gtcttgatga aactgttcca gcacatgctg atgctgatgg cgaatatcga 3003721 ttgaaaactg gacgcggccc ggtatgacat tggctacatt gggctctgcc gttatttttc 3003781 cgcatgtcag acggagctca tccggcagct catccgaccg cagcagcagc tcatgaatga 3003841 tacggctgct ggctgcgagc gggtccttgc gccatttcat ggaggtggtt cctgcgtgat 3003901 tgcattctcc ttcgagcgtg acgagatatc gtctctgccc cgcaatactt gtcacgatgc 3003961 cgagatcccg gcctgacatt tccaacgtct tcccctgttc aatatgcagc tcaacaaacg 3004021 cgctgatatc tgtcctatat gctgactgaa acacaccttt gccaaaaccg ctctcatgca 3004081 tcgctgtttg gagggagact cccgactcgt ctcttggctc ttttgcatct tgttctgaaa 3004141 aaacacccgt catattcccc gacccccaat aggtcattgg aaaacggctg ccttcctcct 3004201 cacataagga gaccgcctcg agcgtttttt ttggcgctcc gtatgtttcc ttgagctgct 3004261 ttaacgcgag cattgccgcc agaacgccat aggcgccgtc gtattttcct ccattgatga 3004321 cagtatcgat atgtgaaccg gttacaatga cttcatccgg agactgggtg cccgaaagcc 3004381 ttccaaacac attgccgaca tcgtcgaatc ttgtttcaag cccgaaagaa gacatttccg 3004441 ttttcacagc aagctgtgcg tccatccact cttttgtgta taaaagcctc gttacgccgc 3004501 catccgcaga cgcaccgtat tgggcgagcc attcaatata atctgtgatg ctgtttttta 3004561 ctgaaagctt ctgcttttcc atgtactccc ccctctggcc gctatggtga cttcattata 3004621 gaaggagcaa catgatagtt cattgacaga ttaaccaaaa aaacgtttat tttttagcca 3004681 cagtatccat ccagcaacca gatacaccct acatgtcaca actattttga tgtaaaggtc 3004741 aaaagaaaac acggtaagga agagagccag caagagcgaa agagagggtc aaaatgcctt 3004801 tcatatgaac aagctaagct ggagaggcga tgttcgcgga acggatgaaa acagaaatgc 3004861 cggcagcccg caaaaacagg acctaaagat atggaaacag gagatttccg cctcctccaa 3004921 agggactaat ttacaatttt aatgaaaaat atacaaaatg acacttctat cctttatttc 3004981 aattttagat aatagatatg atctgataaa aggagggcaa gtgatgacaa aaaaagcatg 3005041 gtttctgccg ctcgtctgtg tattactgat ttccggatgg cttgcgccag cagcttcagc 3005101 aagcgcgcaa accacattaa gccttaatga ccgattggcg tcttcccctt caggaacggg 3005161 aagccttctc tcattagccg cccccgctgc accctatgct gacacagata cctattatga 3005221 aggggctgaa ggtaaaacag gagactcgct aaaaagcacc ctgcaccgta ttatcagcgg 3005281 acacacgatg ctgtcctaca gcgaagtgtg gaacgcgctg aaagaaacgg atgaagaccc 3005341 aagaaatccg aataacgtca tcctgctcta tacgaatgaa tcgcgttcca aaaacctgaa 3005401 cggcggcaat gtcggcgatt ggaaccgcga gcatgtctgg gcgaaatccc atggcgattt 3005461 tggtacgagc aagggacctg gtactgatat tcatcatttg cgcccggctg atgttcaagt 3005521 taacagcgcc agaggaaata tggattttga caatggcggc actgaatatg cgaaggcacc 3005581 cggaaattat tatgacggcg attcatggga gccccgcgat gatgtgaaag gcgatgttgc 3005641 ccgcatgctg ttttacatgg ctgtccgtta cgagggtgat gacggctatc ctgatcttga 3005701 gcttaatgat aagacaggca acggctcagc tccttatcat ggcaaacaat ctgtcctgct 3005761 cgaatggaat aagcaggatc cggttgacga ccgcgagcgg aaaagaaatg aaatcattta 3005821 tgaaaaatat cagcacaacc gcaatccatt tatcgaccac cctgaatggg cggatgagat 3005881 ttggccgtaa gaaaaaggtg ctccttttga ggagcacctt tttctaatac acagcctctt 3005941 ccgtttccgc atcgaaaaag acgacgtggt ccattttcac tgagagctgg attgaatcgc 3006001 ctgcatcgat tcgcgtgttt ccgtccaggc ggaccttgag ccgctcgtcc ccagccatga 3006061 catgcactat gagctccgag cccagatttt cattcacttc cacgttcgct tgaaacactg 3006121 aatcaaacaa ctggtcattt cctgtcattt gtgtgatgtg ctccggccgt acaccggcaa 3006181 tcatctgttc tccggcatat cccttttcct tcagccgctt tgctttttct tcaggaatat 3006241 gaagccggat cgaagaattt gtgaaaaaca gctcgccatg ctgctgttct atgatgcctt 3006301 tcaaaaagtt cattccggga gagccaatga agcctgcgac aaacaaattg gccgggtaat 3006361 gataaatgtc atgaggtttc gccacttgct gaatttcccc ttcattcatg acgacaatcc 3006421 gatctcccat tgtcattgct tcggtctggt catgcgtgac ataaatgatc gttgcctcta 3006481 atcgctggtg cagcttgctg atttctgtcc gcatcgtcac tcttagtttt gcatccagat 3006541 tagaaagcgg ctcgtccatt aaaaagacct tcggctccct cacaatcgac ctgccaagcg 3006601 ccaccctttg ccgctgcccg ccggagagcg ccttcggttt tctcttcagc aaatgttcaa 3006661 tttctaaaat tctggctgcc gcatgaaccc gctcggcaat ttcctgtttc gccatctttc 3006721 tgagctttaa tccaaacgcc atattatcaa aaaccgtcat atgcggataa agcgcatagt 3006781 tctggaatac catcgcaata tcacgttctt tcggcggaag atcattgacc cgctccccat 3006841 caataagaag atttccttca gaaatgcttt ctaatccagc caccatccgc agcgttgttg 3006901 attttccgca tcctgacggc cccaccagca ccaaaagctc cttatccttt acatctaaat 3006961 caaagtcctt cacggttaat tgtgagtgat atgatttttt gacgtgttca aatgttaatg 3007021 aagccatcag aaaagtcccc ctatcttttg acccgttatt tcgtcactgg aaacaacttg 3007081 gtctttctgt tatttttaga gtaatcgatt cccatttttg ctatatttct aaaataaaaa 3007141 atgtaaattt gtattataac gtcataatac attataatat aaataatagg ttaaaaggag 3007201 gctacccttt gttaaacaac ggaagttcta cacctttata cattcagcta aaacaaatca 3007261 tcactgatga catcaaaaag ggcgtgtatt ccccaaccgc caagctgcct accgaaaacg 3007321 agctttgcac caagtataac gtcagccgca tcaccgtcag gaaagccatt ctcgatttag 3007381 tcgaagaagg ctatctgatc aggcagcagg gaaagggaac gttcgttaaa agccctaaat 3007441 taaaacgaga gctgatcgct gtaaacggct actcggaatt tatggaatca accggcaaaa 3007501 aaccgaagca tcatgtgctg tcccatgaca tcattccagc gtcaaaaccc atcgccgaaa 3007561 agcttcaaat ccaacccgag agccctgtgg ttgaattaaa acggatttta tataatgatg 3007621 atcagcctct cacctttgaa gtgacgcatt atccgcttga tttgtttccc ggcattgata 3007681 cctttattgc tgacggcgtc tccatgcatg atattttgaa acagcaatac aaagttgtac 3007741 ccacgcacaa tacgaagcta ttaaacgttg tatatgccca acaggaggaa agcaaatacc 3007801 tggattgtga tatcggggat gcgctgtttg aaattgataa aacggctttt acatcaaacg 3007861 accagccaat ctattgctca ttgtttttga tgcacacaaa ccgtgtcact tttaccatca 3007921 acagccccta cacataacag gcataaaaaa cgagacactg cttatagtat tctcgttttt 3007981 tcactgcttc ccccgtcctc caagcgataa ggatagccat agccgaaagc tccgtacaca 3008041 ccgcaagttt tcgcagccgt ttcagcagcc tggcgcaaag catacgttat atcctgcttc 3008101 acgcaaaagg cagtcaaaaa gcctgctata aaagaatctc ccgctccaag tgtatctatt 3008161 atatcagctt ccacaatcgg ctgatgatag actcgatcac ccgcagacag gattgctcct 3008221 tggccccctc gggtcataca aaccattttg gctccgtacc catgagctgt tttggcaagc 3008281 tcaccgcatt ccgactcact caaatcgctt cctgaaaaaa acgcatacgt cacataagga 3008341 cagaccctcc tcaaataatc atcctcccga ttggttgaaa aatcaaatga gaccgggacc 3008401 agcccgcaca gctgcggaag atcgttctca agcctgctgt acacgctcgt atgcagcaga 3008461 tcatgcccgc tgataaaaga tacatctttc tcctgaaacg cgaggcgaag ccgggactga 3008521 atgccgcctt tatttgatct gacaaaaatg cggtccccct gttcatcaag ggtgacaatc 3008581 gccatcccgt tttctccgtg cgcctggcgg atataatctg cattgacctg ctccagcttg 3008641 agaacgttca acagatgcgc cgcggcttcg tcattgccga cgattccgat ataggaagac 3008701 tcatgcccga gccgcttggc aagcacagca acgtttaagg catttcctcc cgggtaaaat 3008761 gtttcttgat cctggtagta atctacaaca ttatctccaa ccgcaatcaa tttcatagcg 3008821 cttcctcctt tatcctttta cactgccgct tgcaatcccg cggacaaaat atttctgcat 3008881 caataaaaat agaataataa tcggcgcggc tgaaatcgtt aaccccgcca gcaggacgcc 3008941 ccagtctgtc tgcagcgcgt ctctgaactg catcagcccg gctggaatgg tccgtaaatt 3009001 ctcatcatct atgaaaataa tcgcaaacat aaactcattc catgtatggt aagccgtcaa 3009061 aatgccggat gtcaccaaaa tcggcacgct cattggtaag aaaattctga aaaatactcc 3009121 aaaacttgta cacccatcca aataggccgc ctcctccaat tcttttgaaa tagaaagaaa 3009181 ataagagcgg atcaaaatga tggtgaatgg gatccgataa gccgcatacg gcaagattaa 3009241 cgcccaatac gtattgtaca ggcccagcga ctgaataata gaataaagcg gcacaagact 3009301 gacctgcggc gtcagcatca atccgccaag acatagcacc aaaaagaatc cttttccttt 3009361 aaactcaaac cgggaaaggc catacgctgc ccatgcactg ataaagacag tgatcacaca 3009421 cgtcagcgcc gtaacgatga cactgttcat aaaataagaa gaaatcccct gattccaggc 3009481 ggaaacaaaa ttttccggat gccacgaaga cggcagcgac cagctgtgct caaaaatatc 3009541 gtcagagttt ttaaaggcgc tcatcaccat ccagagaagc ggataggcaa tcgcaatcag 3009601 ataaagaaac agaaaaaccc acacagacgt ttctccgata taccattttc gtctaggctt 3009661 atctttcacc tcaatgtgct ggtcaggcac cggctccaat ctgaacgaat ctgtcttctt 3009721 ctgaggcagc atcagttact cctcctttcc ggttttaaag aacttcattt gcatgagcga 3009781 taatgcaagc gtaatgatta acacgacagt ggcaatcgct gaggcgtagc ccatcatatc 3009841 ctttgtaaag gcgcttttat ataaaaacgt gctcaagact tctgacgctt ttcccggccc 3009901 gccgcctgtc aaaatgtacg gctcattaaa gaccgtaaag gctccggtca gcgtcatgac 3009961 caccgcaaca aaagacatct ctttcgtctg gggaacagta atatgaaaaa actgctgaat 3010021 tttacccgcg ccgtcaagcc gggccgcttc atacagttca tccggtattt tttgaatcga 3010081 cacgatgtac agcatcgcaa tataaccgac agattgccac tgggacacaa aaatgacaga 3010141 aagcatagct gtgctgtcat ccccgagcca ggccctcgtc agctgatcaa gaccgatggc 3010201 ctgaagcagc tgattcaaaa gccctgtctc cggattgtaa ataaaatcaa acaaaagcgc 3010261 gatcaccgtc attgagatga caaccggcaa aaagaaaacg gtacgaaaaa acggcgacca 3010321 ttttctgacc agcttatcct caagcaccgc cgccaaaatc aaaccgccaa atacctggca 3010381 tacaattgag atcactgcat aaagcacatt attggtaagt gcctgataga agacaggatc 3010441 atgaaataat tcaacatagt tttttaagcc gataaacgtt ttttccggag aaaatgagct 3010501 ccactgaaac aggctgagga atacattctc aaaaatcggg atataaacga aaagtaaaaa 3010561 aacgagagcg ggcaccaaaa acaaataggg gattatttta ttctgattga ccaagggtat 3010621 ctcatctcct ttataaaaag aaaaggtgcg aagcttcacc ttttctttga tttattcagc 3010681 tgacgccctc acctgctttg ctgccttttg aacggctttc atcacctgct gcggtgtcat 3010741 gtcgccgcca agcatttgct ggacgcccgt taggtacgca tctgcgactt caacatcgac 3010801 atccatatca aaccatggaa ccattgattt ggcatcaaca atatgctgaa cggcttcacg 3010861 ctgaatggct gttgcatttt cttcagtagc cgtaccttgc actgcactgt atttcccgac 3010921 atctttcacg agcttttcgc ccattctttt cgacgtcaag aactgcaaaa attccatcgc 3010981 ttccttcgga tgttttgttc ttgaggagat catgaatcct tccggcgctc ccgttaacgc 3011041 ttctgaagat cctttctgcc cgctgatttc aggaaatggg aacatcccga gattaaccgg 3011101 ttcaaccagc ttgatttccg ctgtttccgc atatatcatc gccgactttc cgctcttaaa 3011161 ttgctgtctc acatattcgt ggtcgacgga gtttacatgt ttattaaagt aaggcatcag 3011221 ctcttgaagc ttttcaagtg cttttacgta gccttcatca gtaaattcac ccgttttggc 3011281 gttatagtcc ttttcccgtg ttttttcatc gaccatccgc tgattaagcg tgccgatata 3011341 gtgcgagatt gtccaagtcg cctttgttcc aaagctgatc ggtgtgtagc catgttcttt 3011401 cagctttttt gacacatcga ttaattcatc ccacgtcttc gggggatcaa gattcagctt 3011461 ttggaaaatg tctttattat agaagaatga tttagcgtcc atttgccacg gtacgccata 3011521 ttgcttgttt tcataagtaa atggtgtaat ttgcgattga acgagctgtg atgaccaatc 3011581 ggtgtcattt ttgtagtagg acgagagatc aagtgcttta ttgcctctga taaatttaaa 3011641 agcaaactca tcgctccaag agaagtaaat gtcaggaggg ctggtggttc ccagcatgac 3011701 cttaatttta tctttatagg agtcatttaa aacggcttca atttgaatgt cgatatctgg 3011761 gtgatctttt tcaaattcct taacaacctc ttcaaaataa cttttttccg gctcctttgg 3011821 ccatctgtgg aaaaatttca atgtcacctt tccgtccgct gaactgcttt ggctcgaaca 3011881 gcctgcgatg gtgagcatac tgacagctgc aatgatcaag aacaacaaca ttttcttcaa 3011941 agggttggcc tcctctggac attagactat aatgttatat aacattatag tctaatgcat 3012001 aatggttctt cattttcaga tcaatactca actttccaca tgtatcttct atgagataaa 3012061 ggatgatttc tctcctctgc cagctcgtct gcatagcttc tcagcacacg attgagaacg 3012121 agcggagcaa gatagccttt aactgaatcg tcaattgcag tgaagtcgta agatgcagca 3012181 tcaagcacag tgagcttttt gccatacttt ttcgagaagg taagcgcccg ctcttcaaga 3012241 ggtcttgttt catctaaacc gagcaggatg ataaacggca cggattcatc aataatttca 3012301 aacggtccgt gaaaatattc tccggcatga atggcgtggg aatgaatcca ttgcatttcc 3012361 atgagaatgc agatgctgta ggagtaagcg acaccgtagt ttgcaccgct tgccatggta 3012421 taaataatgc tttctttttc atgggctttt gcaaattgct tggcgttgtc agcttcctgc 3012481 ttaagggctt tttcatatac agcctgcaat tgatctaagc cttcaattgc ttgctcaaat 3012541 ttcgtattgt tttctaatac ttgcagggtt ccaaaaacga tttgatacaa aacgccatag 3012601 tttgtattga tcgcaagcgc ctcatcaccc caatcgtact gggcaacata ttgcgcttcc 3012661 tgcgctaaag gagactccgg tttaaacgtc atcgcaatcg taagtgcgcc cttgcccctt 3012721 gcaaacgcag cagctttgac tgtctccggg gtatttcccg aatgcgagca caaaataaca 3012781 agagactttt caccaagctg aacagggttg cgctgaataa attcgttggc gctgtagaga 3012841 tcggagttta ttgattttga ctctctgtca aacacatact tactcggata cataatggca 3012901 gaagaccctc cgcatgcgac aaagaataca tgatcaatgg ttttcccttt caaatcctgc 3012961 aagaaagctt gaacctcacg atttactttt gctgtggcct gactcaaatc cttcactcct 3013021 cgtttttatt atataacgtt atataacatt atatattgtt atattaaagt ccgcgggtag 3013081 gattgtcaat attattttct gaaatttctc aataatttat tcggatgaca gacaaagggt 3013141 ctatatgcga aaaaatgccc aaatcaaaag ccagaacttg acttaagctc tggcttcgct 3013201 gttcaatccg cagactgacg tcttatttaa aaaatacctt gtctatattg tacttcgagt 3013261 gctgtgtatt gatgatatat gtttcgtaaa tctctctttc cattggatca tcaactacac 3013321 atacctcaat tttataaact tcatctctgt gatgtttgat cggtgaaaca gtgtcttcga 3013381 aatgcttctt aattctctgt cttaactttc tggctttacc gacaaacagc agctcgtcat 3013441 gaatgttgta aaacataaaa atgccgcctt tgtcccttgg gatctggtga aagtcgatga 3013501 atccgtgaat cggttttatc ttcggctcgt tatcattagc tgactgctgt cgttcagtga 3013561 tggtgacatt cggtgcgggt atatcaattt ttatcaaaat cagttcacgt cctctttttc 3013621 attaaagata aatgctaaca catacagaaa agaaaagcta gaacagcttt attatatttg 3013681 tttgtcatgc tcttacttat tatgcaagtg ctccggctgg atcataagga ctaaggtcta 3013741 attctgtctg ctttccgaga actagctttg cgagctctgc acccaaaaac ggccccatcg 3013801 tcagtccaga agcacccaaa ccgtttgcag cgtacaggcc ttgaacattc ggcacggccc 3013861 ctacgaccgg cagaaatccc ggtgtaaacg gcctgaagcc cactcttgtt tcaacagcag 3013921 ccgcatcagc aagacccggt gcaacggcta acgctttgct caatacttcg tgctggcctc 3013981 cggctgtcac acgaagatca tcaagaccgg catcgttttc gtgtgtggcg ccggctacaa 3014041 ttctgccgtt atcaaacgac agaatgtact gatcactcgg cggcattaca accggccacg 3014101 atcctgtatc tgcatctgtc atttcaaaat gcataatctg cgctttttga aatgacactt 3014161 gaaaatgaat gccaagaggc ttcaatatct cattggccca tgctcccgcc gtcacaatga 3014221 ccgcgtcagc cgcaaactgc tttgtatctg tttgcacgcc ggtgactgtt ccgttttcaa 3014281 aaagcaagga cgcatttcct ttgatgaccg ttgcgccgcg tttctctgca gcgcttaaaa 3014341 gcgaccggca cagcgctctt ccgttcacac gggcggcacc gctgatatga accgattcat 3014401 agccgtcagc taaaatcgga aacagctttt tcgtttcact tgcagacaag cgggtaatgt 3014461 cgccgatttc cggcgcatcc tcccgtctct tatacgccct ttcctccatt ttatcgagtt 3014521 tagacgcgtc agtatgaatg ctgatggcac cgacacgttt gtatcctgta tccgattcac 3014581 cgtctttttc caattgatgg attaaatcct tatagtaccg cgctcccccc ttagcaagct 3014641 ggtaccaatc ctgattacgg cgctgcgaga gccaaggaca gacgatcccc gccgccgcat 3014701 cagtcgcttg tcccggctct ttccgatcaa tgacagtaac gcgagcgcct gtttttgcga 3014761 gatgataagc cgtcgacgcg cccagaatcc ctgcgccgac gatgatgtac gatttcatat 3014821 gcaaacacct tttctattat aatgtctatt cattttacca aatcaaatgc tttccttcga 3014881 ccttttgccc taatgtggaa aaaccgcgaa gttcgtccaa tctctttact ctcctatcga 3014941 atatcctgtc actatcaata gagaaaggat gataccatga gcgaaaatcg tcatgaaaat 3015001 gaagaaaaca gacgcgatgc ggcagtggca aaagtccaaa acagcggtaa tgcaaaagtc 3015061 gtggtcagcg tgaacacaga tcaggatcag gcacaggcgc agtcacaaga cggagaagac 3015121 taatgaacga aaacatcatt cctcttaaca gacatactca agagataccc actactgaat 3015181 ctgttatcaa aaacagcggc aactcagagg tccatatcga cattcacatt gatacaatgc 3015241 caattgcttt tgctatatta tgctctgcat tagccgcaaa gcagatgaca aaagaggaat 3015301 tcgatatggc ttatactcaa ttgcgagaga tgaacagaga aaataacagc agatcatctg 3015361 taaagcaaat tatcaatcaa gagacagaag aagagtaaaa aaccgcggcc cctcggccag 3015421 cggtttttct tctgcataca aaaaggacgc gactgaatcg gttacttctg tacaatttga 3015481 ataaggttac cgcatgtatc gtcgaagaca gctattgtga cttcgcccat ttttgtcggt 3015541 tccgtcgtaa acgtcacgcc tttttccttt aatcggttgt actctttttg aatatctgca 3015601 acgccaaaca ttgtggccgg gaggccttcg gagaatatct tcttttgata ctccttggcg 3015661 gcaggatgtt cattcggttc gagtaaaagc tcggttccgt cttgatcatc tggagaaaca 3015721 agcgttatcc acctgaattt ccccatggga acgtcttcct tttttataaa cccaagtttt 3015781 tctgtataaa actccagtgc catgtcttga tcttgtacaa atatactggt aacaacgatt 3015841 ttcatactgt ttttccctcc ttcgatatga atgaagcatg gtactatgct aacaatctgg 3015901 ctacaagcaa aacaacccac acatttatca gaggccctgt tctgatttta taaaattatt 3015961 ctatccatcc tttcagcaaa tttttaagcg gttcgttgtt gaatataagt actcgatatt 3016021 ttccctttcg ttttgatgtt acgagtcctg catcctccag tacagaaagg tgtttagcta 3016081 tcgcctgtcg cgtaatagaa aggtcgtact ttgtaataag acgtatcgta agttcataca 3016141 acgtcagctc gttgcgttca gataattcgt ctaatataag ccgccgagtc gaatcgccga 3016201 gtgctttgaa tatagcgtct ttgttcccat tcatatattg agtataagca acccattagt 3016261 tgcatgtcaa gtataagcaa ctgtatggtt gcgtgatata gaaactgaac ctatccggcg 3016321 caggtctgaa atattctaat cgataaggaa ttaaaaccat taaaataaca gtggatatgt 3016381 ctctgaaaaa taaaagaaga cgaacttcaa aagttcgtct tctacaatca aattcggcac 3016441 gccggccatt ttaaagttga taactatctc taaacccctt gataaacaaa ggagttttca 3016501 tcattaaccg atagaacctt ccatttcgaa cttaatcaaa cggttcattt caactgcgta 3016561 ttccatcgga agctcttttg tgaatggctc gataaagccc attacgatca tttcagttgc 3016621 ttcttcttca gaaataccgc ggctcatcaa gtagaagagc tgctcttcag atactttaga 3016681 cactttcgct tcgtgctcca atgaaatgtt atcatttaag atttcattgt aaggaattgt 3016741 gtcagaagtt gatttgttat ccataatgag cgtatcacac tcgatgttag agcgggcgcc 3016801 ttccgctttg cgtccgaagt ggacgattcc gcggtacgtt acttttccgc cctgttttga 3016861 aatcgatttt gatacgattg tagatgatgt gtttggtgca aggtgaatca ttttcgcacc 3016921 tgcatcctga tgctggcctt tacccgcaag agcgatagaa agcgtcatac cgcgcgcgcc 3016981 ttcgcctttt aggatacaag ccggatattt cattgtcagc ttagaaccga tgttgccgtc 3017041 gatccattcc attgttgcgt tttcttcaca gactgtacgc tttgttacaa ggttgtaaac 3017101 gttgttcgcc cagttttgga tcgttgtata acggcagtag ccgccttttt tcacgatgat 3017161 ctcaacgacc gcactgtgaa gtgagtttgt tgtgtaaaca ggcgcagtac agccttcaac 3017221 ataatgaacg cttgcttctt cgtcaacaat gatcagtgta cgttcgaact gacccatgtt 3017281 ctcagagttg atacggaagt aagcttgtag cggtgtttca accttcacgc ctttaggcac 3017341 gtagatgaaa gaaccgccgg accaaacagc tgagttaagc gccgcaaact tgttatcagt 3017401 cggcgggatt acttttgccc agtgctcacg gaaaatatct tcattctctt tcagcgcgct 3017461 gtcagtgtct ttaaagacga tgccttgtgc ttcaagatct tctttcatgt tgtggtatac 3017521 aacctcagat tcgtactgag cagaaacacc cgcaaggtat ttttgttcag cttcaggaat 3017581 accgagcttg tcgaatgttt gtttaatttc ttcaggaact tcatcccaag aacgctctga 3017641 acgctcagac ggttttacgt agtacgtaat ttcgtcaaag ttcagtgagt ttaaatctcc 3017701 gccccattga ggcatcggca tattgtagaa atgctcaagt gatttcaagc ggaagtcaag 3017761 catccattga ggctcttctt tcatgcgaga aatttcttct acgatttctt ttgtcaatcc 3017821 gcgctctgaa cggaaaatgg aaacgtcctt gtcgtgaaaa ccatacttgt attcaccaat 3017881 atcaggcatt tttttagcca tccattttca ctccaatcct tttaattgcc gccttcttct 3017941 ttcgcgactc ctttttcaag tgctttccat gacagggttg cacatttgat acgggcaggg 3018001 aattttgaaa cgccttgaag ggcttcaata tccccgagat ctatagaatc atcatactct 3018061 ttcccttgca tcatatccga gaaaatctta gacatggaaa gggcagtttc aatatctttc 3018121 cctttaatcg cctgagtcat catcgaagcg gatgccattg aaatggaaca gccttcccct 3018181 tcaaacttcg catcttccac gatgtctccg tcaagcttca ttgtcagtct gatgcggtcg 3018241 ccgcatgtcg gattgttcat atccacgaca atgctgtcat ttaaaacccc tttatttcgc 3018301 gggtttttgt aatgatccat aatcacctgt ctgtacaatg tatctaagtt tgcattaaaa 3018361 gacatttgta aaatactcct ttgtcttttg aagagcttcc acaagcttat caatctcttc 3018421 ctctgtatta tacagataaa agcttgctct tgcagtagca gttacatcca gccatttcat 3018481 cagcggctgc gcacaatggt ggccggctct gactgcgatt ccctccgcat caagcacagt 3018541 cgccacatcg tgcggatgaa catcatcaag gttaaatgtg acaagcccgg cacgctcttc 3018601 cggcccgtaa accgttacgc cgtcaagctg gcggaagcgt tcaagcgcat aagctgcaag 3018661 cttgtgctca tggcgggaaa tctcatcaag accgatttct tcgagaaaat caatggcggc 3018721 accgaggccg attgctcctg caataatcgg cgtacccgct tcgaatttcc acggaagctc 3018781 tttccaagtt gattcataaa gcccgacaaa gtcgatcatt tcaccgccga attcggcagg 3018841 ctccatgttt tccagcaggg ctttctttcc gtacagcaca ccaacaccgg taggtccgca 3018901 cattttatgg gaagaaagcg caaagaagtc gcaatcgaga tcctgcacgt caattttcat 3018961 gtgaggcgtg ctttgtgcac cgtccaccac aatgacagcc ccattgtcat gagcgatttt 3019021 cgccatttct ttaatcgggt tgaccgtgcc gagaacatta gatacatgag acaccgcaac 3019081 aatttttgtg ttgcttgtga ccgtttctct gacgtcttct aaagaaatcg ttccgtcttc 3019141 ctgcaacgga atatatttta atgtggcgcc agttgctttt acagcctgct gccacggaat 3019201 gatattcgca tgatgctcca tgtaggtgat gaccacttca tcaccaggtt tcaggttggc 3019261 gcgcgcatag cttaacgcca ccatattcag tgatgtggtc gtgccttttg tgaaaataat 3019321 ctcagccatt gacttcgcgt taataaactt gcggactttt tcacgcgctc cttcataacc 3019381 atctgtcgct ctggttccaa gtgtatggac gccccggtga acattggaat tgtattggtt 3019441 ataatactta tccagtgttt caatgacagc acgcggcttc tgggaagtcg ccgcgctgtc 3019501 gagataaacg agatcatgtc cgttcacttg ctgatgaagg atcgggaact gttcacgaat 3019561 atctgtgata ttcattactt cactttcctt tcgataacag aaactaattg tttcttaacg 3019621 ccttcaatcg gaagttcatt tactaccggt gcaaggaatc cgtaaatgac taagcgttct 3019681 gcttcttctt tcggaattcc gcggctcatc aggtagtaaa gctgaatagg gtccacacgg 3019741 ccgacagatg ccgcatgtcc tgcagttaca tcgtcttcgt caattaaaag aatagggttt 3019801 gcgtctccgc gtgctttttc gctaagcatc agcacgcgtg attcttgctc cgcattcgct 3019861 ttagaagcgc catgttcgat tttgccgatt ccgttaaaga tagaagaagc ggaatccttc 3019921 atcacaccgt gcttcaagat atagccttca gaagctttac cgaaatggat gatttgtgtt 3019981 gtgaagtttt ctgtttgctc tcctcttccg acaacaaccg ttttcgtatc gccgtatgtg 3020041 ccgtcaccgt aaaggtttgt tgtgttttcg gaaatcgtgt cgccatcgtt catcaggccg 3020101 agagcccact cgattttgct gtcgcgtccg cgcgcagcac cgcggcggtt cacataagtt 3020161 gtcacaccgc ttgacagatt atccaccgca ccgtatgtca cgctggcatt atcacctgtg 3020221 atgacctcac tgataatatt gaagacagcg tctttcgggt ttacagtgct gatgtagttt 3020281 tctacatatg ttacagagct gtggtcttca gccacaatca gcacgtggtt gaatagagct 3020341 gtatcattgc tttcgtggac ataaacagcc tgaaccggcg tctccacctg aacatttttc 3020401 ggaacataaa ggaatgctcc tccgttaaca agagccgcgt gaagtgcagt taacttatgt 3020461 tcgtcaacct tcacgccgtc cttcataaag tatttctcca ccaagtcgct gtgctcgcgt 3020521 gcagcagtca gaatatcagt gaagatgacg cctttgtctt tcaattcttg agaaagagaa 3020581 agatgtgccg gcgtctggtc acgctgtacg tataatgttt tatcttcgtt ttcaatgtcg 3020641 atcagcgctt ttacttcatc agtcaaatct tctaatgaag aaagcggttc gttatccact 3020701 gtatgcttcg cgaaattcgt gaagttccag tttgtgattt ttgttttgtc aggtttcggc 3020761 atcggcagat cctcagcttg ttcaagagcc tgtaagcgca ggttcttcag ccaggcaggt 3020821 tcttggtgct tttcggaaaa gcttttgaga tactcctgat ctacggatag ttttgtacct 3020881 agtgtcatat taatccccct aacgcttacg cttcttggcc aacagtttcg tcttcaatgc 3020941 caagttcttg tttgatccag tcataacctt ctgcttcaag acgctgtgca agctctgcac 3021001 cgccggattt tacaacgcgg ccttgcatca taacgtgaac aacatccgga gtgatgtagt 3021061 ttaacaggcg ctgatagtga gtgatcatca ggcagccgaa gttttcgctg cgcattttgt 3021121 tgatcccttt tgatacaact ttcaaagcgt caatatcaag gcctgagtca atttcatcaa 3021181 ggatggcgat tttcggttca atcatcatta attgaaggat ttcgttgcgt tttttctccc 3021241 cgcctgagaa gccttcgtta agatagcgct gagccatttc agggtccatt tcaaggaact 3021301 ccatgttttc gtccattttg cggatgaatt tcatgagaga aatttcatcg ccttcttctc 3021361 tgcgcgcgtt gattgctgag cgaaggaagt cggcatttgt cacaccgctg atttcacttg 3021421 ggtactgcat tgcaaggaat aagcctgcct gcgcacgctc gtccacttcc atctccagta 3021481 catctttgcc gtcaagcgtg atgctgcctt ttgttacttc atatttagga tgccccataa 3021541 tagcagctga taaagtggat ttaccagttc cgttcgggcc cattactgcg tggaattctc 3021601 caccttttat ttcaaggttt acacccttta agatctcttt cccttcgatt tcaacgtgaa 3021661 gatctttgat cgttaatgtt gaagcagcca tatctatacc tccaaaaata tataatcatt 3021721 attctcattt tattctcatt ctaattttat aacaaatgaa aagtaaatac aactttttat 3021781 cgtgccttgc acattcctca agtttaacaa agatcagcac tttattaaag cgattgaaaa 3021841 agaaaaagag tggattccca ccctttttta aaagattgat tttctcaata agctcccgca 3021901 gaaatccgct tgcttttttc ataatcaagc tctctctgcc gctctacttt cattcttgtt 3021961 tccagccggc gtccatattc ctcgtatcca attccgtgtg acagctgcat cgctttttcc 3022021 atttctgacg tataatcgag gttcagtctg tcctggctgc tgcaaataat gaatcaatcc 3022081 cttcatatat ttgcttttta ttgtaccagt gctgcgttgg atgccgcaaa aacgatttgg 3022141 cgtgaaatag cggcagatga gacgaaagca tcctttcaga acaaatgaga atggtttttc 3022201 ggaatattcc ttctcttaat gcgtggtgtt tccgaattcc tcaatgcact gttgaacgac 3022261 tgtcacgcct tggctgaaag ctgcgccgcc tccaaatgcc gctgccacac tgacggcttc 3022321 gagaatgttt tcttctgacg ctccctgatc aagacagcct tttgtatgat agatcatgca 3022381 atattcgtcc tgagcattga tggcaattcc gagggcgatc agctgttttt ctctttcagt 3022441 cagagaattc ccggcaaagc actgttcagt aaattcgtta aattttcttc ccatcagcgg 3022501 catcttttgt tcaaatgtgc ctaaaccatg tttatattgt tttaacgcgt cctgcatgct 3022561 tcctctgtct tgattcaaag aaaatccctc catctgttta acattccttt ttattatgaa 3022621 cagcttttag gaaaatacgc gaaaaaaacc ccggaattct catccggggt ttcagtctta 3022681 ttcagataca ggaagcacag ctccgtcgta ttttttctcg atgaagtctt tgatcttttt 3022741 agagtgaaga acttccatca gcgctttgat ttttgcagaa tcttcttcgc cttttcttac 3022801 tgcgatgatg ttagcgtatg ggttgttttt cgttgattct acttcaattg cgtctttttt 3022861 aggatttaat ttattttgga tcgcatagtt tacattgatg aagaccgcgt ctccttcttt 3022921 gttttcatat gcttttgccg ttaattcagg cgctactttt ttgaattcaa ggtttttcgg 3022981 gtttttctta atgtctttca atgttgcgtc aactgtttcc actttagaat caagagtgat 3023041 taatccagcg ttttcaagca ttgcaagcat acggccttgt tcagcaacgt tgtttgtcag 3023101 aatgattgtc gcaccgtctg gaaggtcttt cagtgatttg tatgttttag agtaaatacc 3023161 gaatggctct aagtgaacag cgccggcatt cacaagtttg taatctgtgt tttctttcat 3023221 ttcttgctca aggtaaggaa tgtgctggaa gtagttcgcg tccacttctt tatcagctaa 3023281 agctttattg tacattttgt aatcactaag cactttcact ttcagcgtat agcctttttc 3023341 tttcagcaat ggttcagctt cttttaaaat ttccgcatgc ggtgtttttg ttgccgcaac 3023401 gacaatttct ttcttgccgg attcagcgcc gttattcgaa ccgcaggcag ccataactcc 3023461 tgcaaataca agcagtaatg cacccaaaaa tagctttttc aatgtaaatc ctcccttatc 3023521 gtttgtctat aatatttgtt attagatcac cgatgatttg aataataaac acgatgatta 3023581 aaataaacac agtagcaacg aaggtaacat cagcgttatt agactgatat ccttctacgt 3023641 acgcaaggtt tccaaggcct cctgaaccaa tggctccggc aattgccgtt gaaccgatta 3023701 aagcgatggc tgtaaccgta atgccagaaa taagagcagg cattgattcc ggaatcagca 3023761 ctttgaaaat aatcgtagac gttttcgcgc ccattgattt agctgcttca atcacacctt 3023821 tatccacctc acgcagcgcg atttcaacaa ggcgcgcgta aaatggtgcc gagccgatta 3023881 ccagcgccgg caatgcggcg tttggcccta agatcgtgcc gactaaaaat ttcgtaaaac 3023941 ctaatagtaa aataattaaa ataaggaacg gaatcgatct gaatatgtta acaacggctg 3024001 caatcactga gttgaccgct ttattctgcc agaggcttcc tttgctcgtc agaaagagca 3024061 gcaagccgag gatgaccccg atgacaaaag caaacagtaa agaaatcagc gtcatataaa 3024121 gtgtttcata tgtcgcgttc cataattcag ttaaatcaac gttcgggaag tatttttcaa 3024181 acattcgtga tcacctctgc tttcacctgt ttgtcattaa tgaatcggat cacgttttgc 3024241 acttcttcct cgtccccgtc aatgtggatg aacagtgaac cgtaagcccc atccttcgtc 3024301 tgcgaaattt tcccttgcag aatattgacg ctgacattga agtttctgat catctctgta 3024361 atcagaggct gttcagctga ctcaccgaca aatgtgagct gaaccatttt tcctgatgct 3024421 gtatcatcaa gaaggtgctg aagcgtctct ttcgtttctt ccggctctgt cacctgttga 3024481 acaaatcgtt ttgtcatttg ttcctttgga tttttgaaga catcgagaac ctcgccttct 3024541 tcgaccacct tgccgttttc catgacggcg actctgttgc agattttgcg tatgacatgc 3024601 atttcgtgcg taatcagcac aatcgtcaaa ccgagtcttt cattaatatc ggacaataga 3024661 tccagaattg aatctgtcgt ttgcggatct aatgctgatg tcgcttcgtc acaaagaaga 3024721 accttcggat tgtttgcaag cgctctggca attccgacac gctgcttctg accgccgctc 3024781 agctgggacg gataagattt ttcttttcct tctaaaccta ccagtttaat cagttcattg 3024841 gcgcgcttga tccgctcgct ctttttcacc ccggcaattt ctaaaggaaa catgatatta 3024901 tctctgacag tccgcgacca aagcaaattg aaatgctgga aaatcatact gatctcatgg 3024961 cgtgcttttc ttaaaccgcg tccatttact tcattaatct tggttcccgc cacttccacg 3025021 gttcctgagg ttggtttctc aaggccgttc agcagacgga ttaaggaact cttaccagct 3025081 ccgctatatc ctataattcc aaaaatctca ccttttttaa tggaaagcga gacgttttgg 3025141 acagcattga catctccatg tttcgacttg taaacttttg aaacatcctg aagattgatc 3025201 aaagcaatca cctgccttaa cactattcta agaaatcttc cggttttttc tgcaaaagaa 3025261 aagcctttct gcacacttga gcagaaaggc ttatataaaa tgcctttctc tcatctttca 3025321 aagctgaacg cttcgtgtga attggcacca tttcaacagt gttgatggtt gccgggcttc 3025381 atagggcact tccctccacc tctcttgata agagaaatat atagtctttt tcgtccggaa 3025441 attcttaatg tagaatagca cggcgaatga ttaaatgtca ataaaataaa tgatgtcaac 3025501 ttttactatt ataataattt attatttttt aattttttaa aatcctctga aaaaatccat 3025561 ttgtcagcca gagaatggct tccagcttta acagggccct gaatgacccc tttactttga 3025621 ggcttccgct ctgaataagg tgctgaaggg aaatgtctcc gtgcaataaa tcaataattt 3025681 ccgtttggtt tccgtaaaag gtcaggttgg acgtttgggg cggagaaact tttttcattt 3025741 ctccctgttc gtttattgag acggttaagg cttctgcttc tccttggaag gtaatgagca 3025801 atgttgaggc attcaaaagg ggttttaaaa acagatgctg atactcatct tctaaaactt 3025861 ccgctttctc catatgtaca acctcctatt tgttggtcat acatacacat ttctctcttt 3025921 gtcgcaagaa cccctttata aaacgaacga caatttcatt ggatatgctg agaaatatgt 3025981 cataaatggg atgcggaaga tgatttttgt ttgatcagct catataaata agaaacggaa 3026041 tgaaatgcat atcctctttc gaccatcttt ccgcctttaa acagcagaaa acaagggacg 3026101 ctttcaattt gatacgcttt tgcgaatgtc ggagagtaat tgacattgtt ttgatagaag 3026161 gcgacatccg gcagcatttc tttcaccact gtcagcattt tgcttgcaag ctggcaggtg 3026221 ccgcaaaacg gagtatataa atatagaagg tacacatcat cttcaatgtg atcaagttcg 3026281 tgttcttgga gttctttcat gctatacacc tcgggacttt ctttcaagaa aaatagtatg 3026341 gacattcaga ttcgcacgca gcaatacaga agcgatatgg tgcctgggcg cagccgctac 3026401 ttccttatag gctctgtcga catggagatg gcaggcttca ttaaattcac gcttcagctg 3026461 ttttctcaat ttctcacctg attcatcagc atcaactaat atatagacgt ctttatcata 3026521 aagctcgtca gccaattcct cgagcctcag ctggctgatt gttccgtttg tgcagataat 3026581 gcgcatcggt tcattcagga cgctttcgat tttctcttta tctgatttcc cctcgacaat 3026641 cataaccttt tccagctcat ccatcttcat cttgttcacc tgccgcgtca aatttgaaat 3026701 gttcagattg taaaagaagg cagtgaaatt caccgccaac attaacacca gccgttttcg 3026761 tagtcacaat ctacatattt tgcgtcgtct ccagagacca catcggctgt cttataaaat 3026821 ttctcatttt caaaggaata accggactta agctcatatt cattcatgct tgtcatttgg 3026881 ccgatcatct cattatcatg atataacgag agccggccat tttgaaagcg gcctgtcacg 3026941 tcattggtga catcgagctt ttgtttgtcg aaagccatat tggacacctc ccataacgtt 3027001 agcgtgtcca attgctttta cggctatcct gttttagtct tcttgtgtca tctcttcgta 3027061 ttgctctgct gtcatcagtt tttcaatttc agaagcgtca gatggctcaa cgacgatcat 3027121 ccatgctttt tcgtacggag attcgttgac gaattccgga ctgtcatcaa gatcttcgtt 3027181 tacttccaca accgttccgt taatcggtgc ataaagctca gataccgttt taacggattc 3027241 aacactgccg aatggctcgt ccgctttgat ttcagcgccc acttcaggaa gttcgacaaa 3027301 cacgatgtcg cctagttcgg actgggcaaa atgcgtaatt ccgattctgg ctttttctcc 3027361 ttcaactttt acccactcgt gttctcctga gtaacgcaaa tcttttggta tgctcaattg 3027421 aatccctcca ttttttacag cactacaata agaagatacc acacttttca aaaaaaattt 3027481 acattaagcc cagttttctt caaattggtc ttctttaaat ccgacagtca ctttttcgcc 3027541 gtctgttgta agcgggcgtt taattagcat accatctgaa gccagcagtt cgagctgttc 3027601 gtcctctgac atatgataca gcttttcctt gagattgagc tcgcggtatt tcatgccgct 3027661 cgtgttgaaa aatttcttga gatccagccc gcttttttca taaagcgctt ttaattcttc 3027721 tttgcttggc ggctgctcag caatatgtat ttcgtttatt tctttcccat gctcttcaag 3027781 ccacttcttt gctttgcggc acgttccgca tttagggtac cagtaaaaag ttaacgacat 3027841 cttcttcccc ctcaataaaa taatcgaggt tattttaaca cagtttgttt taaaaaccta 3027901 aaacagtgct tcttaaaaaa gagctccgcg catgcggagc tcatggccaa tcagacagta 3027961 tatttctcag cctcaaaaat gcctgccgcc gcctcgcgtt ttttctgaat cacgttttta 3028021 ggcgttacgc gtgtcagctt gcgcagagcg gaaagcatca tgcggagtga atctccttct 3028081 tccattgcga taagggattc ctttgcatgc gcttcgattt cgttaaaggc ctcttgaacg 3028141 aaaatttctg tgtacagcac cttttgcgct gctttttcag cgccttgtgc ggcaatggcc 3028201 ttttccgttc tgagcacggc tgattccatt gcgtatacat tgctgacgat atccgctacg 3028261 ttcacgagaa tttcttgctc acgatcgatc gcttttccgt atttttgcgc ggctaggccg 3028321 gcagcaaaca acgcaatttt tttggcttgc ttgacgatat atttctcctg ctctaagacg 3028381 ccgcttccag gctcttcagg cataagcatc atgagttctt cctgcagcga ctgcgctttt 3028441 tcgaataaag gcagctcgcc tttaagcgct tttttcagga aggtgcttgg cacgattaac 3028501 cggttgattt cgtttgtgcc ttcaaaaatc cgattgatcc ttgaatccct ataggccctt 3028561 tctacttcgt attcctgcat aaagccgtag cctccatgaa tctgcacgcc ttcatcaacg 3028621 atataatcaa gcgtttcaga gccgaatacc ttattcagag agcattcgat ggcgtattcc 3028681 gcaatcgatt tggcgatttg ccggccgtcc ttgagatctt cggccgtgaa ctggctcata 3028741 ttgtcttcaa acagcccgac ggttctgtat acagagcttt ccatcgcata cagccttgag 3028801 gccattgtcc cgattttttc ctgtgtcaat gaaaaaccag caatcggcgt tttaaattgg 3028861 cggcgctgat ttgcgtatgc cgcagacagc tcgatgacgc gtttagatgc gccgattgtg 3028921 ccaaccgcca gtttgtaacg gccgatgttt aaaatattaa aggcgatgac atgccctttg 3028981 ccgatttctc cgagcaggtt ttcctttggc acttcagctt gatccagaat gagggttctt 3029041 gtcgatgatc ccttgattcc cattttcttt tcttccggtc ccgtggagac acccgggaac 3029101 tctttttcta caataaaggc tgaaaacttg tcgccgtcta ccttagcgta aactacaaat 3029161 acatcggcaa aagcagagtt ggtaatccac tgtttttccc ctgttaatac ataatgggtt 3029221 cctgcttcat tcagcacagc tgttgttttt gctccaagtg catcagaccc agagccaggc 3029281 tcagtcagag cataagcggc gatcttttcg cctgaagcga gtccaggcaa atattttttc 3029341 ttttgttctt ctgacccgaa aaagacgatc ggcaaggaac cgataccgac atgcgcgcca 3029401 taagaaagag aaaagcttcc cgcacgcgaa aatttctcag tgatgagtgc cgagctgatt 3029461 ttatcaaggc cgagcccgcc gtattcttcc ggcacatcgg cgccaagcag ccctagttcg 3029521 cccgctttct tcaacagtct gacagaatgc tcgaattgat ggttttcgat atcatctata 3029581 tgagggagaa catcttgctc gatgtaatcc tctgttgttt tcgcaatcat tttatgctcg 3029641 tcagtgaaat cctccggtgt atacatttga tcgtatgtga catcctcgat taaaaatccg 3029701 ccgccttttt gtacgtcagc cgcttttttt gccatttgtt tttccccctt tagcataatt 3029761 caaatacacc ggccgctccc attccgccgc cgatacacat ggtcacgact ccaaattgct 3029821 cgtttctccg tttcatttca tggatgagtg agagtgtaag ctttgtgccc gtacagccaa 3029881 gcgggtgtcc aagcgcgatt gcgcccccgt tgacattcac tttttcttca tcaattccca 3029941 attccctgat tacttgaatg gcctgtgagg caaaagcttc attcagttca aacaagccga 3030001 tgtcctgcag ctgaagtccg gcaagcttca aagcgcgcgg aatcgcttcc accggtccga 3030061 ttcccatcac ttccggcggc acgccgccta ccgcaaagga gcggaatttc acaagcggcg 3030121 ccaggccaag agcatcggct ttttcccggt ccatcagcat gacagccgcc gctccgtcac 3030181 tcgtttgtga ggaattgccc gcagtcaccg tcccgtcaac ggaaaaggcc gggcgcaatg 3030241 tcgataagat gtctgcagtc gtttgcgggc gaacaccttc atcctgagaa aacacaaact 3030301 gtttttccat aggcttatgg tcttctccga tttctgtcac cgtcacttcg acgggtacaa 3030361 tttcatcttt aaattttcct tctgcaaggg ctttagcggc gttttgatgg ctgcgaacgg 3030421 caaacgcgtc ttgatcctca cgggagacgc cgtatttttt cgcgacttgc tcggctgtgt 3030481 gccccatgct catataatat tccggtgcct tttctgccaa agcaaggttc ggacgggtaa 3030541 catgccccat catcggaact tgcgacatgg attctgctcc gccggcgatc gctgtatcgt 3030601 aggcgcccag cataattttt tctgctgcat acgcaataga ctgaaggcct gaagagcaat 3030661 agcggttaac tgtaatcgcc ggaaccgtgt acggcaggcc cgcgagcgca ccgatatttc 3030721 tcgccatatt aagcccctgc tccgcttcag gtgttgcaca gccgataatc aagtcatcaa 3030781 tattgccttc gtagccgcct gcccgtttca gcgtttcttt tacacaaatc gctcccaaat 3030841 catccgggcg aacggtggcc aacgatcctt tttttgcttt tccaaccggt gttcttgcac 3030901 ctgacacaat gactgcctct ttcataagct ccctcctaat tccgtaaagg tttacctttc 3030961 acaagcatat gctgcattct cgcttgagat tttgcctctc ctgacaaact caaaaacgct 3031021 tctctttcga tctccaataa atactcttca tcaacctctg taccaaacgg cacttttccg 3031081 cccgcaatga cataagcgag ttttttcgcg atcttaaaat catgctcaga tatatagccg 3031141 gacagcttca tctgctcagc gccaagcaag agtgccgcat aaccggtttc tcccggcacc 3031201 ttgacctttt cttttacagg cggccgccag ccggtatcgt ataaagatgc ggccagctgc 3031261 ttcgcatcgt ataacaggtg gtcttgattc acgctgatct gatccgtttc ttttaagatg 3031321 ttcatctcac gagcctcttg agcggaagcg gacactttcg ccatcgcgat tgtttcaaat 3031381 gttttcattg ccgcattcat cggatcatgg ccgcggcgaa gatggttgat gtacagctct 3031441 ttgttacctc ctccgccagg gatgaggccg acaccggatt ccacaagtcc catataggct 3031501 tcgcttgccg cttgaatgcg cgccgccggc aggcatgctt ccgttcctcc gccgagcgtc 3031561 atgccaaatg gcgcggcgac gaccggtttc gcactgtatt tgatcttcat catcgtctcc 3031621 tgaaaacggc ggatcacaaa atcaacttcc aaaaagttgt catcttggac ttccattaag 3031681 atcatggcga gattcgcgcc gacgcagaaa tttttccctt gattgccgat gacaagcccc 3031741 ttgtaattcc gttctgtttc ctctaatcct ttgtggatca tttgaatgat atcgaggccg 3031801 atcgcattgc ttttcgaatg aaattcaaga agggccacat catctccaag gtcaattaag 3031861 cttgctccgc tgtttttcgc aatcacgcct tttgtttctt taagtgcttg taaatgaatt 3031921 cgttttttgt tttctttcac ggctctgtat tcgccgcggt cataataaaa taccgttccg 3031981 ttctctttga tgtagaaggt ttcatttcct ttgtccagca tctcttttat ccagccaggc 3032041 atatctgctc caagctgctc aagcttttcc gctgactgct tgaggccgat ggcgtcccac 3032101 atctcaaaag gtcccagttc ccagccgaat ccccacttca tggcttggtc aatcgcatga 3032161 atatcatcgg caatctcgcc aagcagctcg gctgagtaaa gcagggtttg agaagtgata 3032221 ttccacagca aacggccggc cctgtcatcc gaataaataa gcgctttcat tttggctttt 3032281 gtcccttttg cctgttttgc cgcttcaagt gccggtgatt tcatttttgt ccgctcgccg 3032341 taagtaagcg tcactgggtc aagctcataa atcgtttttc cttctttttt ataaaagcct 3032401 tggccggcct tgcttccgat ccaccctttt tccagcatat cgttcatgaa gcttggaatg 3032461 cgaaacactt ctttttcatc gccatcagct ttgtcataca catttcgggc aacgtgggcg 3032521 aatgtatcga ggccgaccac atcaagcgtt ctaaaggtgg cgcttttcgg cctgccgatc 3032581 agcggtcctg tgatcgaatc aacctccccg acctgataac cgcctttcag catttcttgg 3032641 actgtcacga gaagcccgta agtcccgatg cggtttgcga taaagttcgg tgtgtccttt 3032701 gctgtaacaa cgcctttccc gaggacattt tctccgaaag ctgtcataaa ctttaaaata 3032761 tcaggatccg tttccttaat cggaatgatc tctagcagct ttaaatatcg tgcgggatta 3032821 aaaaaatgcg ttccaagaaa atgggcttta aaatcatccg accggccttc agccatttcc 3032881 tgcactgata tgccggatgt gttgcttgag acgatgcttc cagtctttcg atgttcatcc 3032941 acaagagcga aaattttctt tttgacttca aggttttcga caacgacctc aataatccaa 3033001 tctgcttctt tcagtttttc tgcatcatcc tccagattgc caggtgtaat ataggaggta 3033061 tttttcgctg atgtgagggg agcgggcttt tgtttcagca gttttttcat cgcctgccgg 3033121 ctcagcctgc tgcgcacctc cgaactgtcc ttcgtcagcc cctttttttc ctcttccttt 3033181 gtcaaatcgt tcggcacaat atctagcagc aggacaggaa ttccgatgtt agccaaatgc 3033241 gccgctatcc cggaacccat tacccccgat cctaaaacgg ctgccttccg aatgtgtttg 3033301 tgcatgagat atcccccttg aacattgaat gaatagtcat tcattttttg actaaaaaaa 3033361 atgaaacccg tttcttcttt catcttaaaa gatttccggt tcgacttcaa tagctaattt 3033421 gttatttttt tgtatgaagc ctataaaagt cgggcaactt aagcccggag gtgaagggaa 3033481 tggtacgaga gaaaaaaaat ccgtcttcag cggcagtcag cgcggcgagc gtaaagggag 3033541 atgccggtcc gactcagcat tacggcggcg gaaaacggac aagtcaaaat cagcagtata 3033601 aaaaacataa catgggacaa tcataatgca gctgcttccc acggctgctt tcactttttc 3033661 aaaattcctt ttaacacaaa cgctgcattg gcaggccgtt cggcaattct tctcataaag 3033721 tagctgaacc agtccgttcc atatgggaca tacacacgca ttctgtagcc ttccttggcg 3033781 agttccttct gacgctccgg cctgatgccg tatagcattt gaaactcaaa ttgcgatgcg 3033841 gggatttgat gttcggcgac gagctgtttc gtaaatgcaa tgatgtcatc gtcatgtgtg 3033901 gcgacagccg tgtagttccc gcttaacaac tgcagcttta ttaagctctg aaaatgaagg 3033961 tccgtgcctc ttttgtcggg aaacgctaca gccgcagatt ctttataagc gccttttaca 3034021 agtctgagat tcggctttaa gtcccgcatc tttctgatat cttctgccgc ccggtacaaa 3034081 tacgcctgaa tgaccgtgcc gagcttctca aattcctgtt tgcattgcct gtaaatagaa 3034141 agtgtctgtt cataatgaga atagtcttcc atatcaatgg tcacagcaac atcatattgc 3034201 ttcgcaacgg aaagaatggc gcgcaaatga gtaagagcaa gttcttctga aagatcgagc 3034261 ccgattgagg tcagcttaag tgaaagctct gaattcaatt gatgttcggc aatggcttga 3034321 atggctttct tgcattcctc tgcgacttgg tttgcttctt tttccgaagc tgcatactcg 3034381 cctaaataat caattgttgc acacaaaccg gatctgttta gccttttgac ggtcttaacc 3034441 gccgattcaa tcgtatcccc tgcgacaaac cttcgtgctc caagccgcgt tccgtatgct 3034501 tttgcgaact tggtaagtgt tttattttga gataagaata aaaacacatg tctcaacatc 3034561 cgactccctc ccgccgtcat cttcaaaaca cctgtatata actcccagtc tgaaggaaac 3034621 tataaaatga acagaaacca aaggaggatc acaatggata atcagcagca atctcaaatg 3034681 ccgccttccg ttatttcgac aaaggatcat ttgtatctca atgacatgct gaactggaat 3034741 ttgctcgcga tgaaaaaagc gcatttcatg gcgcagcagt gccaggatca aacgttaaag 3034801 caagaactcg accgcgtcgg acacatgcat catgatcact atcaaagaat attaaagcac 3034861 ctgcagccag gccagcagca gtccggctac atccaataag gaggcgccag aatgaatcag 3034921 caaaatcaaa aaatcagcaa cccgcagaca cctgtaccga caacatcgga aatgaatgac 3034981 agagatttcg tcaacgaatt gctgacaacc gaaaaataca tgacaacagc ttattgcact 3035041 gccttgcacg aattcagcca cgagtctctt tatcaggata ttcaatccat ttttgatgag 3035101 tcacaaaaag cgcaaagaaa actatatgat ctcatgttcc aatatggatg gtattctgtt 3035161 gaagcggagg attcacaaaa gctgcagcag tcctatcaaa aattccagca gaccattcag 3035221 cagcagtctc cttatcagca ataacaacat tagtaaaaag gatacgatgt tctttcgggc 3035281 atctatcctt tttttgtgta aaatcagttg acttttcatt tacgcttatt tatatttaat 3035341 aagcattaac tattttgtca ttaaaatata tatacagtgt atgtaacaga ggggaaatga 3035401 atatgaagag tgcggatcag ttaatgtccg atattcaatt atcgcttcag gcgctctttc 3035461 aaaagataca gcctgaaatg ctggaaagca tggagaaaca aggtgtcacc ccagcgcagc 3035521 tgtttgtgct ggccagccta aagaaacacg gcagcctcaa agtttctgaa attgccgagc 3035581 gtatggaggt gaagccaagc gcggtgacgc tgatggcaga tcgccttgaa caaaaaaatc 3035641 ttatcgccag aacacacaac acaaaagaca ggcgagtgat tgatctcagt cttactgacg 3035701 aaggagacat aaagttcgag gaggttttgg cgggcagaaa agccataatg gcgcgctatc 3035761 tttccttttt gacggaggag gaaatgctgc aggcggcgca tattacagca aaactcgcac 3035821 aagcagcaga aacggatgaa aagcaaaaca tgaaaagagg aaacggatga aaatgagtaa 3035881 agaaggcaaa caatcaaaac gaacgttatt aataacaggc ttaattattg ccatgttttt 3035941 ttcagccctt gacggtacca ttgtcggaac ggccatgccg aaaattgtcg gtgatctggg 3036001 cggtttgagc atgatgacct ggctgacaac tgcatatttg ttaacatcaa caaccattgt 3036061 tccaattgcc ggtaaactgg ctgatttatt gggacgccgc attgtctatg tatcaggttt 3036121 gattattttt atggccgctt ctgctttgtg cggaatggcc aacaacatga cggaattgat 3036181 tatcttccgt ggactgcagg gcatcggcgg aggcatcatg atgccgatgg cgatgattgt 3036241 catcggtgac ttgttcacag gaaaacagcg tgctaaattc caaggtgtct ttggcgcaat 3036301 ttacgggctg gcttcagtga ttgggccgca aatcggcggc tggattgtag actcgttaaa 3036361 ctggaaatgg gttttctata ttaacctgcc agtcggaatt attgcggtta tttttattgc 3036421 caggggatta cagggacgcc agcagactgg tccgatcaac ttcgatatcg ctggtatttt 3036481 cacaatgatt gtcggtgtgg tcagcctcct gctcgcctta agctttggcg gaaaagatta 3036541 tgcatgggat tcatggcaga ttcttgggtt gttcgctctc gcactgatcg gcattgtcag 3036601 ctttatcatc gtagaatcaa aagcaaaaga gccaatcctg ccaatgtatt tatttaaaaa 3036661 cagaacattt acatttctaa acttgatcgg cttctttatg agtatcggta tgtttggcgc 3036721 cattacgttt gttcctttct ttatgcaggg aattgtcggt gtaagtgcgt ctgaatcggg 3036781 tacaattatg acaccgatga tgatttctat gattatcaca agtatcatcg gcggacagct 3036841 tgtttataaa attgggatta aaccgcaaat cattacaggc atgctggtta tggccggcgg 3036901 attcctgctg ttaacgacat tggatctcga cacgagcaag cttgtcgcta catcttttat 3036961 ggcgattatt ggtctgggaa tgggtcttgt tatgccgatt ctgacattgg ctttacagga 3037021 aagcttttcg aaggaggagc ttggagttgt cacttcatcc agccaattct tccgttctat 3037081 cggcggaaca ttcggcatta ccatgctggg agccgtaatg aatgcgagat caggaaatct 3037141 attaacagat aaattggttc catatttaga ctctcttccg gcacaggcaa gctcgtttgc 3037201 cgcccagcta aagggtatga ttgatacaaa tccgcaaggg ctgctgcaat cactgttcag 3037261 tccggacgcg gtcaaacaaa tccctgcggc tttctcatcc catattgtgc cgattttaaa 3037321 aacatcgttg atggattcgc tccacagcgt gttttatacg ggcctgatct ttatcgcagt 3037381 cggagccgta ttcaccttgt tcttaaaacc tatcaagcta tcaaataaga aagcggaaga 3037441 ccaacaagaa aaagagaagg cggcaaaagc cgttgaatca ccttcccatt aatagagcac 3037501 cccgcgggta tcaatccgcg gggtttttta ttcaatcatc tgggctcttc catttccgaa 3037561 agaccaatcc tcatcctgat ttccggccag catgataaac acatcttctt ttcttacacc 3037621 aagctcggaa tgaatccggc tcgcgattga gcggtaaagt gcttttttct gttcagttgt 3037681 tcttgactgt ttcagtgtaa aatgaatgta tatcagttca tcagtacgct cgacttggag 3037741 ataaaatgga tcataaaaaa attcgctttt ttcatattgt ctgatgactt ggaaatagtc 3037801 atcttccggc acattgattt cttcaatcat cgattggtgg atagtcctgc tcagtttttg 3037861 aagccacact tcgcttcttc ccgaccgtaa atgaatctgt acaaatggca tctccccgca 3037921 tccctttctt tacagcgtct gtccgctgtc aattgtgata atttggcctg tgagtgattc 3037981 ctgttcaatt agtgaacaaa tcaatttggc aacatcatct ggttcagcaa tacactgcag 3038041 cagcaaagag ccgatcatgc ttttcatttt ttcttcccgt ccggcccacc atctcgttgc 3038101 cacagctcct ggtgctacac cgctcactct gatttcaggc gctaaggcgt gggccaatga 3038161 tttcgttaaa ccgtgcaccg ctgattttga tactgcgtaa ggcattgatg agccggcacc 3038221 agttatccct gcgatgctgc cgacgtttac gatcgccccg tccttgcttt tcttcatgaa 3038281 cggaaccact gcccgcgcgc agaaaaacat ccctttcaca ttgacggcat acagctcatc 3038341 ctagacgtct tctgtcgcag cctcaagatc atccattgga atatgccgtg taatgctggc 3038401 attgttgact aaaatatcaa ccgtgccgtg tgtgttcacg attgcttgaa tcatatcctg 3038461 cacgtcgctg tttttggata catctgcttg gatggcgaag gcttgcccgc cagctttttg 3038521 aatcatttcc actgtttcct ccgcttctga ttgcgagcgt gaataattca ccgccacaat 3038581 cgccccacgc tttgccaatt ccatactggc tgcttttccg attcctgtgc cgccccccgt 3038641 tacgagagct attttgttca agacattcat tgccgccact ccttgctgtt gactaaagta 3038701 tatttctgat tccattgtaa tccagctttg atgttacgta taatgattgt taaagatact 3038761 agatatcact cagattgata gtaaacgaac ggaggagttc aaaatggaaa gcggagattt 3038821 acgtgtgttt caaatggtag ctcgtgaagg gaccattacg aaagcagccc tgcagcttgg 3038881 ctatgtacaa tcgaatgtca cggccagaat tcaacaattg gaagctgagc tgggtaccac 3038941 actgtttttg cgccataatc ggggcatgac actttctgca agcggaaaat tgctgctgga 3039001 ctacgcaaat aaaattatag gccttcttga tgaagcgtct aaagcgctct catcctccgc 3039061 agaaccaagc gggccgctta tgatcggctg cactcagaca accgccgcgg taaggcttcc 3039121 aaagcttctg gcatcttatt atgaagaaca tccaaacgtc cagctgtctt taacaacagg 3039181 acatacgcaa tttctccttg ataaagttct tcgttatgaa ttggatggcg cgtttatcgg 3039241 atgcgaatgc catcatcctg agctcgaatc ctatcctgcg tttgaggaag aaccagtagt 3039301 tgtttcggct gcctccgtgc ccgatgttga ggaagccatc acaaagccga ttctcgttta 3039361 cagcacaggc tgttcgtatc gagaaacact tgaaaaatgg ctgcgttccg tcggtgtcac 3039421 acagccggtc attatggaat ttgggacgct tgaagcaatt atcggcgggg ttacagcagg 3039481 tcttggcatc tcgttgctgc caagaacggt tgtgcagaaa catgaagcag aaggatcaat 3039541 tcgattgtac ccgctgcctg aagctctcag ccagatgaaa acagagttta ttgttcgaaa 3039601 agattcgttt atcagcagcg cgctgagaac ctttatggat tcctttacgc cagttaaaac 3039661 ggctgaatca caaaaaagca gtctgctata atgaacagac tgctttttgg ctattgtttg 3039721 tttcgatgcg cttcatttaa ttccttaata tgctgaatga tctctttaat gccctgcttc 3039781 gcgtcggggt atgtcgcatt ccaatgctta gcgagcggag gcatgctttt ggctatatgg 3039841 gtgtacaaaa tccattgctt cacttcttct tttagctcat cgtttgtttc accaagcaga 3039901 agctcagtat acttctccag caatccatca agctgctcct gaagtttttg ttccattttc 3039961 catcttcctt tcgaaaaaac agcaaggagc tttctcaatt gaaagctcct tcgctgcgtt 3040021 atttatccat gtgatgtgaa agccgcttcc tggacaatgc atctgcccct gccatgagga 3040081 atgcaaagag gcgttccgaa gagcgggtcc tgtgtaacct gacagttcat agaaaacaca 3040141 ttttgcacaa gatcacaagt gatgacctct tccggacggc cttctgcata aatccgttta 3040201 tcttttatgg ccacaagatg atgcgcatag cggcacgcca agtttaagtc atggagaacc 3040261 ataacaatcg tccggtcttc cttttcattc agctcaaaca gcaaatcaag aatttcaatt 3040321 tgatgcgtca tgtctaaata cgtcgtcggc tcgtcaagaa ggatgatatc cgtttcctgg 3040381 gcaagcgtca tcgcgatcca agcccgctgg cgctgtccgc ctgacaaaga atcaacggca 3040441 cggtcagcca tgtcctcaag ctttgttgct ttaagcgctc tttcaactgc ttcctcatcc 3040501 tcttttgacc actgcttcag ccagttttgg taaggatatc ttccttgctt caccagctga 3040561 tgcaccgtca gcccctctgg agccgaagga ccttggggca ggattgcgag ctcttttgcg 3040621 acttccttcg tcggaagctt ggcaatcgct cttccttcca gcagcactga accgcctctc 3040681 ggcttcatca ggcgcgctaa tgaacgtaaa agtgtcgatt ttccgcagcc attgctgcca 3040741 ataaatacgg taatttcacc tttgggaatt gttaaattca actcatcaat aataacggca 3040801 tccccgtatc ctaagctcag cgtttctgta gaaattgcac tcatacccat aaccgctcct 3040861 ttttgctggc tttttagcag cactatgtat tgcacgtttt ctatatacat gcttttaagt 3040921 caattgtcat caatgcaaat gattccgata ttcagccatt tgatatggtc atatatccct 3040981 cattgtagca gaaaacactg actttgaaaa tcattttcaa ttagttttat ggacataatt 3041041 gacgtttatg ggttttttat cacaagatta cttcttgatt tctctgatgg agccgtcctt 3041101 cagcttcaat tttaaatcga tatgatcata atgactgtcc agattaaatg ctgccagcac 3041161 actgtgtatc acttctgttt cagccatttg gtctgtcacg gaaagctcgc tcaaaatcat 3041221 tttcatctca tctaacgctt cttctccttc ctgattgaca ccggagagct tatcctgtat 3041281 ttccgctttt tcctgagtcc cgttctttgt atagattcct tcataacggt tatgctcacc 3041341 atccccgtag ctcacacgaa gcgaaaaatt actgtaggga acggacttca gctgggtgac 3041401 ggctgtattt tctccttctg cctgatgctg gtcttcattg aaacggcagc ccgcaatcag 3041461 aaccactgcg agacatacag ccccggctgc tctgatcaaa tgcatatgtt tcccccctgt 3041521 aggattccat ttattttagg tatatccaga gaatgaaatc ctcattcaga gaagaattga 3041581 aaaagccggg gcatttaacg ccacggcttt ttctttaaga ttcggtcatt tgtaaaaagg 3041641 tttcggcgtc acgcacagcc agcttgatgg cattctccca gaaatcgcgc tttgtgatgt 3041701 cagcgcccaa atgcttcatc gccaaatcct ccactgtcat agaagccgta tcgcgcaata 3041761 gcgccatata cttctcttcg aatgtgtctt tttcttcaag cgccaacgcg taaataccaa 3041821 gagaaaacag gtagccgaat gtataaggga aattgtaaaa cggcaccctc gtgatgtgaa 3041881 aatgaagctt tgatgcccaa aaaagcggat gatattcttc taacgcattg cagtatgcct 3041941 ctctttgcgc ctcttccatc agctcattca agcggctggc cggtaccact ccccgctttc 3042001 gttcctcgta gaatctcgtt tcaaatagaa atcttgcgtg aatgttcatg aagaacgcaa 3042061 cgcttctttg cactttatcc tccagaagaa caagcttttc ttccctcgtc tcggcctgct 3042121 ggacagtcgc gtccgccact atcatctctg caaacgttga agctgtttct gcaacgttca 3042181 tggcgtagga acggtttaac ggcctgacgt tgagcattgc ttcctgatgg aacgcgtgcc 3042241 cgagttcatg cgcaagggta gagacatttg aggcgcttcc cgaaaatgtc atgaaaatcc 3042301 gggattcccc gctgtccgga aaactggtgc aaaagccgcc gactcttttt ccgctcctgt 3042361 cttccgcctc aatccagccg tcccgaaacg ctttttcagt gaatgaggac agctttttgc 3042421 caaacgttga aaactggctg gtaatgatat ttgcggcttc atcatacgaa tagacctttc 3042481 cgtcagaacc gatcggtgcc tcgacatcgt accagctgag tttttcaagg ccgagcatgg 3042541 atgctttccg gttcaaaaac tgaacgaacg gcttcttgtt ttcagtgatg acctgccaca 3042601 tcgtatcaag tgtttctttt ttcatcctgt taatttgcag cggttccttc aggacattct 3042661 cccagccgcg cgctttatag gtttcaagcc ggaatcccgc caaatgattc agcgtgctgc 3042721 tgaaaatatc ttgcttgctc tcccaagctt ggcggaaacg ttcatatact gtttttctga 3042781 cagtacggtc ttgatgatcc atcatattct ccgcctgacc gacagacaat tgcttgtttt 3042841 caccgttttc ctcatacggg atcgtcattt tcccgacaac catattgtat aagtcactcc 3042901 aagcgtgata tccgtccacc gcaaggtttc cgatcagttt ttccttaccg gggctaagct 3042961 tttcggcaac cctctgtctt ctttcattta atatgtaaga aacatcgcgc aatcccggtt 3043021 ttgttaacaa ttcattccac acgtcttgat taatgtccac aagtttatga tctaatgtaa 3043081 cgagcgacga ttgaaaatct gcggaaagcc gattcatgag gcctgatgct ctatagcctt 3043141 ttgatcattg atattctggg cctggaggca agcaacaaaa gcgccggcct gctgaagctt 3043201 gacggatgtc tgttcgaata aatcaagcaa cgcggtcagc ccttcagcct cttcaggcga 3043261 ttcaggcacc tgaaacgcat cagtcctgtc ttgaaatgca cgcagacttt gtgacagctt 3043321 ctcaatataa cctttgaatt cttccgattg gctcccgccc ttaaaaaatg aatcaagatc 3043381 ccatctttgg cctacccctt gcagcgccat atcacaaaac ccctttcctt ctttcgttct 3043441 attatagaac aattctgaat tattgtataa aaatttctat tacaggcgtc atttcgtgtt 3043501 caggatagta caatagctgt agcagtttaa taggagggtt aggatgaata aaaaaatagc 3043561 catcgtgaca ggagcgtcca gcggcttcgg tctgctggca gctgtaaagc ttgcccgatc 3043621 atttttcgtg atagccacat caagacagcc tgaaaaagcg gaacagcttc gagaattggc 3043681 tgcagcacac aatgtgtctg attctattca cattacagct ctcgatgtca ccgatgaaca 3043741 atctatagtc tcattcggaa aagctgttag tgcttacgcc ccgatcgatt tactcgttaa 3043801 caacgccgga acggcttatg gaggatttat cgaggatgtg ccgatggaac atttcagaca 3043861 acaatttgaa acgaatgtct tcggtgtgat ccatgtgaca aaaaccgtgc tgccttacat 3043921 aagaaagcat ggcggcgcaa agattataaa cgtgagcagc atcagcggac tgacaggatt 3043981 cccagcgctg tcgccatatg tttcttccaa gcatgcattg gaaggttttt ctgaaagcct 3044041 gcgtatcgag ctgcttccgt tcggtatcga aaccgctttg atcgagccgg gctcatacaa 3044101 gacatcgatc tggtcaacgt cattatcaaa ttttatgtcg gtgcctgctg acgattcagc 3044161 ctatcatcaa tactataaaa agatcctttc ctatgttcaa aaaaacggag aagaaagcgg 3044221 agatccccaa gaggttgccg acctcattta tcaattggca acaaaacagc acataaagaa 3044281 tttgcgatac ccgatcggaa agggcatcaa gctcaccctg ctgttccgat cgctttttcc 3044341 ttggtctgcg tgggagtcta tcctgaagaa aaagctattc agctgatcta aattataatt 3044401 attataattt agtattgatt tttatttagt atatgatata attaagtcaa cagatcacaa 3044461 ggaggacgtt atcttatgaa aactgaaaac gcaaaaacaa atcaaacatt agttgagaat 3044521 tcactgaaca cacaattatc aaactggttt cttttatact ctaagctcca ccgtttccat 3044581 tggtatgtga aagggcctca tttctttaca ttgcacgaga aatttgaaga actttatgac 3044641 catgcggctg aaacagtgga taccatcgct gagcgcctgc tggcgattgg cggacagcct 3044701 gttgccacag tgaaagaata cactgagcat gcatctatca cagacggcgg aaacgaaaca 3044761 tcagcatcag aaatggtaca agcattggta aacgactaca aacaaatcag cagcgaatct 3044821 aaattcgtga tcggcctggc tgaagaaaat caagacaatg cgacagcgga cttgtttgtc 3044881 ggattaattg aagaagttga aaaacaagtg tggatgcttt cctcttattt agggtaacaa 3044941 aaaagctgaa ccttaatcgg gttcagcttt ttgttttttc ttagcttgaa ctgctttctg 3045001 tctgcttggt cagtgttgcg ttcaacgttt tcgtttttcc ctttcgcagc acttggattg 3045061 ttgttttatc tccgactttt aagtctttgt aaaggatctg acggatatcc gcactgcttt 3045121 ccacgtcttt accgtttagt ttgacaatga catcctcaga tttaatacct gctttttctg 3045181 ccggcgaatt tgcttgaact tcttttacat aaacaccttt gcccaattga tctccaaaca 3045241 ggccgagcgt attttcctga taggtttcag gaacttgtga catgtcaatc atctgcacgc 3045301 ctaaaaacgg acggtccacc ttcccgtttt gcagcagctg gtcaacaatc ggctcgacat 3045361 cattgcttgg gatcgcaaat ccaagtgatt ccacgccgct ttcgctcacc ttcaagctgt 3045421 tgatgccgat gacctggccg cttgcattga ttaatgggcc tccgctgttc cccggattga 3045481 tcgctgcatc ggtttgcagc acgttcattt ccaccgtccc ctgtgttgta tccacatcaa 3045541 ttgtccggtt cagtccgcta atgatacctt gtgtcactgt accggaaaac tgctgtccga 3045601 gcgggttacc gatagcgatt accttttcgc cagtgcgcag ctgtgaagag tcaccaaagc 3045661 tcgccacttt ttttacattc ttgccgctga tttccaaaac tgccaaatca gtaatggtat 3045721 cgctgccgac aagcttggca gtttccgttt ctccgttgta tagcgtaaca gtcagcttgt 3045781 tcgcgccttc aacgacatgg ttgtttgtaa tgatatacgc tttatcgctg tcttttttga 3045841 aaataacacc tgacccggtt ccgctttcac tttctgagct ggagcctcct cccgtgccga 3045901 atgtgttatt ttgagaggtt tggatatttg agattccgac aatcgtaggc tctaaatcct 3045961 ctaccatatc agcgatgttt gatgcgttcg ttatcggcgc cgttgtaaaa ttatcagact 3046021 gcacctgttt atttgcggaa gcggtttcgg tcgcctgatt ttggtctgac ggcagataag 3046081 gcgcgatgcc aagcatgagg cccccgccga taataccgcc taaaatcggg ctcagccatg 3046141 cggctctccg tttcttttct tttttcacag ccgtttcttg cttttccatt tctaaagcag 3046201 aagccgtttc ctgccgtccc gcttcatacg acacaggcgc gtcaagcaat tcttgttcag 3046261 aatgtccaat cagcttctgg ttttctgtat tctgctgttc tgtatgtgaa ggttcagttt 3046321 gatgttgatc gttttggcca tcacgtcgat aatccatgtt cttacactcc tttaacggtt 3046381 attcatttat cgttacatat tcatcgcatg tacaagttca attgtcccaa taatgaggag 3046441 aaaagcaaag caccaaaata gaatatgttt gatcatccta catcttcctc gctctttttc 3046501 tcttcctttc ttcccttaac catatcataa acaaacattg tgggataaaa atgaaaagaa 3046561 tatgtgaaat tatgaaaatt gcctgccgta tgttaaaact agtttataat gacgttgaaa 3046621 ggatgtgaag agccttgtca tacaccattt atctagttga agatgaggat aacctgaatg 3046681 aactgctgac gaagtattta gagaatgagg gctggaacat tacatctttt acgaaaggtg 3046741 aagacgccag aaagaaaatg acaccgtctc cccacctatg gattctcgat atcatgctgc 3046801 cggataccga cggctataca ttaataaaag aaatcaaggc gaaagatcct gacgtgccgg 3046861 tcatttttat ttccgcccga gatgcggata ttgacagagt gcttggctta gagcttggca 3046921 gcaatgacta catttcaaag ccgtttttgc cgcgggagct gattatccgt gtgcaaaagc 3046981 tgctgcagct cgtatataag gaagctcctc ctgtccaaaa aaatgaaatt gccgtctcct 3047041 cgtatcgggt cgctgaagac gcccgcgagg tctatgacga aaacgggaat atcatcaatt 3047101 tgacgtcaaa ggaatttgat ctgctgctat tatttatcca tcataaaggg catccatact 3047161 ctcgtgagga tatcctccta aaagtgtggg gacatgacta cttcggaaca gaccgggtcg 3047221 ttgatgatct cgtccggaga ctgcgcagaa agatgcctga attgaaggtg gagacgattt 3047281 acggtttcgg ctacaggatg atgtcatcat gaaaaacaag ccgctcgcgt ttcagatatg 3047341 ggttgtcata tccggcatcc tgttagcgat atcgatttta ctgcttgtgt tattttcaaa 3047401 cacgctgcga gattttttca ctaatgaaac gtatacgacg attgaaaatg agcagcatgt 3047461 tctgacagag taccgcctgc caggttcgat tgaaaggcgc tattacagcg aggaagcgac 3047521 ggcgccgaca actgtccgct ccgtacagca cgtgctcctt cctgaaaatg aagaggcttc 3047581 ttcagacaag gatttaagca ttctgtcatc ttcatttatc cacaaggtgt acaagctggc 3047641 tgataagcag gaagctaaaa agaaacgtta cagcgccgac gtcaatggag agaaagtgtt 3047701 ttttgtcatt aaaaagggac tttccgtcaa tggacaatca gcgatgatgc tctcttacgc 3047761 gcttgattct tatcgggacg atttggccta taccttgttc aaacagcttc tgtttattat 3047821 agctgtcgtc attttattaa gctggattcc ggctatttgg cttgcaaagt atttatcaag 3047881 gcctcttgta tcatttgaaa aacacgtcaa acggatttct gaacaggatt gggatgaccc 3047941 agtaaaagtg gaccggaaag atgaaatcgg caaattgggc cataccatcg aagagatgcg 3048001 ccaaaagctt gtgcaaaagg atgaaacaga aagaactcta ttgcaaaata tctctcatga 3048061 tttaaaaacg ccggtcatgg tcatcagagg ctatacacaa tcaattaaag acgggatttt 3048121 tcctaaagga gaccttgaaa acactgtaga tgttattgaa tgcgaagctc ttaagctgga 3048181 gaaaaaaata aaggatttat tatatttaac gaagctggat tatttagcga agcaaaaagt 3048241 gcagcacgac atgttcagta ttgtggaagt gacagaagaa gtcatcgaac gattgaagtg 3048301 ggcgcggaaa gaactatcgt gggaaattga tgtagaagag gatattttga tgccgggcga 3048361 tccggagcaa tggaacaaac tcctcgaaaa cattttggaa aatcaaatcc gctatgctga 3048421 gacaaaaata gaaatcagca tgaaacaaga tgatcgaaat atcgtgatca ccattaaaaa 3048481 tgacggtccg catattgaag atgagatgct ctccagcctc tatgagcctt ttaataaagg 3048541 gaagaaaggc gaattcggca ttggtctaag catcgtaaaa cgaattttaa ctcttcataa 3048601 ggcatctatc tcaattgaaa atgacaaaac gggtgtaaca taccgcatag cagtgccaaa 3048661 atagactgta gatgttttgc agtctatttt tttatgtgaa agaatagccg ttaaaatctc 3048721 tgtaatttgt tttgagcggc tgtttgcatt gatgaaccca ttttttctct gacaaggtct 3048781 gcttcggata tttgactttc tccactttga ttcctctgtt tcgcaagcgg ctgatcattt 3048841 cgtccaattc tctcattcta gattcaccct ttcgcttgag ctttgaccat tcggtcatct 3048901 caatttataa tataaataat acatgataaa aaaacaagtt acaataaggt taattttata 3048961 acagacggtg tgactatatg gtcatatcct agcaggcctc cgggctccga aagggtggaa 3049021 ccattgaagg aaaaagaaaa actgattatt gaaacagcct taaaactatt tgcccaaaaa 3049081 ggatacaact caacatcagt ccaggaaatc gcaaaagaat gcaaaatatc taaaggcgct 3049141 ttttatattt attttccttc gaaagaagcg cttcttctct ctatgctgaa ctactattat 3049201 gataaaacgt ttacccgaat tttaaatatt aaaacgaagg gcgacagccc cagaacggct 3049261 taccgtaaac agctgaccgt cctctatgaa aacattcttg aacacaaaga ttttatcagc 3049321 atgcagttga aggagggttc tctgccttac acagaagaag tggagcaatg cgcaaaaaaa 3049381 atccgccagt cctcacttca atttcatatc gacagcctgc tgaacatcta tggaaaaaaa 3049441 gcggaaccgt acactgctga gctttgtttt ttaatagagg gcatcagcca gatttacctg 3049501 gaatgcatga ttttgctcgg gtacactgtg aagccgtctc aattagctga tatcattatg 3049561 aatcgaattg atgatatggt aaaaggcatg tctgaacgaa acgataagcc tttcatcaca 3049621 ttggaagagg cgagctcttt attcggacct cttacgcacg gacggcctga cccgctgact 3049681 gaatcaattg tgaaaagcct acgtgacaaa attaacagct taaacacaaa ctcctctctt 3049741 gaattatcgg agagcttgga catacttgaa gcagaaatga agaaaaaaac accgaagctg 3049801 gcgatcataa aaggaatgat tcataatctg acggagtctg aagctctcgc caaagatgcg 3049861 gaacagctta aatatttatt aaaacagcaa catatttaga agaacggctg cttaaaaagc 3049921 agccgttctt cctattacgc ctttggtttt accatgtctt ccggcttaac catttcgtta 3049981 aattgctcct ctgtcagcaa ttcaagcttc aaagctgctt ctttgagcgt caatccctct 3050041 ttatgggcaa gcttggcgat tttcgccgcg ttttcataac cgatatgcgg gttcagcgcc 3050101 gtaacaagca ttaatgaatt tgacaggttt tcctgaatgg tttctttatt aggctcaata 3050161 ccgacagcac atttatcatg gaatgaattc atgccgtcac tgagcagctg cacagattgc 3050221 aggaagttgt aaataataac aggcttaaac acgttcagtt caaagttccc ctgactcgcc 3050281 gcaaagccga ttgtcgcatc gttccccatg atttgcgctg cgatcattgt taacgcttcg 3050341 ctttgtgtcg gattgacttt accaggcata atagagcttc ccggctcatt ttcaggaatg 3050401 acgatctccc cgatgccgca gcggggtccg cttgcgagcc atctgacatc gttcgcgatt 3050461 ttcattaagt cagccgcaag cgcttttaat gcgccatgcg cataagtgat ttcgtcatgg 3050521 cttgtcagcg cgtggaattt attcggcgag ctgctgaacg tttggccggt cagcttagtg 3050581 atctcttctg agacaagctc tccaaactct gggtgggcgt tgatacccgt tccgacagcc 3050641 gttccaccaa ttgcaagcgc acgcatttta tctgtcgctt ccaaaatcat ttccttcgaa 3050701 cggtccagca tgtgaaccca tccgctgatt tcctgtccga gggtcagtgg cgtagcatcc 3050761 tgaagatgcg tgcgtccgat tttgacaata tcattgtatg cttttgcttt ttcatccagt 3050821 gtattgcgaa gctgatcaag cgccggcaca agctgctcgt aaacagccaa aacagcggca 3050881 acatgcatcg cagtcgggaa tgtgtcgttt gagctttggc ttcggttcac gtcatcattt 3050941 ggatgaatcg tttgatcaga gttcttctct tttaataaag cagtcgcacg gttggctacc 3051001 acttcgttca tgttcatatt gctttgtgtg ccgcttccgg tctgccatac gacaagcggg 3051061 aagttgtcat cgtacttgcc tttgagcaca tcatcacaaa ccgctgcaat cgcttctgct 3051121 ttttcagcgt ccagattgcc gaggcgttta ttagctagag cagtgcttcg ttttaaaatt 3051181 gcaaacgcct tcacaacacg catcggcatt ttttcagaac cgatcttaaa gttctccttg 3051241 cttcgctgtg tttgggcgcc ccaaaattta tcagcaggaa cttttacttc tcccatggtg 3051301 tctcgttcaa ttctgtattc catttatgta tccctccata acggttgctt caatagatca 3051361 taattcgcca atgacacaaa aaatcctttt tatttttcga tcttggcaga ttttaatttt 3051421 aattcaagat atacgcggga atcctttgaa tatttgtatt ttggatttgt cctgccgtac 3051481 tcctttgatg tataagagac atcataatgc tgttcaaatg atctaatgag ctgttcaatt 3051541 tcttcttgtt ttccagctag ccttacctgt gccacttcgt atcctccgct ttcataaaaa 3051601 aacttactcc atgaaatact ctaacacagt atatcatttt tttaacagga aaagataacc 3051661 tctactaagg ttttggataa gaggtgacct cattggaaca aacagagttt aaggaatata 3051721 tacacgataa tttagcattg gtgctgccaa aattaaaaga aaacgatgat ctggtgaaaa 3051781 acaaaaaaat gcttgcgaac ggactggttt tttactatct ctatttcagt gaaatgactg 3051841 atgagaataa ggtgtcagaa gccattaaaa ctttgattaa agatgaggag accttaacgc 3051901 ttgaccaggt caaaaaacgc cttgaccagc ttgacgcaag acctgttgaa actgcaaaaa 3051961 aaacgattga atcgattctc aacggcaatt gtgctgtgtt tatcaacgga ttggataaag 3052021 cctatattct gaccacagga aagaaaaaaa caagaagcct gacagagccg acaactgaaa 3052081 aagtggttcg cggcccaaaa gtagcgtttg tagaggatat tgatacaaat ctcgctctga 3052141 tcagacaaag aacctctcat ccgaaattga tcaccaaaaa aatcatgatc ggcgaaaaca 3052201 agctgaagcc tgcagccatt atgtacattg aaggcaaagc aaaaaagtcc gtcataaaag 3052261 aagtgaaggc gcggcttaaa aatatccagc tggaagatat ccaggacagc ggaacgctcg 3052321 aggagctcat tgaagataat aaatattcac catttccgca gatacaaaat acggaaagac 3052381 ctgacaaagt atcttcagcc ctgtttaacg gccgtgtggc aattttggtc gacagttcac 3052441 catttgtgct gctggtgccg gtttctctcg gcatcctgat gcaatccccg gatgactact 3052501 atgaacgctg gatttcagca tctcttatcc ggtcgctgcg ctttgcttct atctttatca 3052561 ccttgttttt gtcatcgatt tatataacac ttgtttcctt ccatcagggg ctgctgccga 3052621 ccgcactcgc cgtcacgatt tcggcgaaca gggaaaacgt gccgttccct ccgatatttg 3052681 aagccctgct gatggaagtc accatcgagc tgctaaggga agccggactg cgactcccca 3052741 atccgctcgg acagacgatc ggcctcgttg ggggcgtagt catcggacag gctgctgtag 3052801 aagcgaatct cgtcagttcg attttggtca ttgtcgtcag tgtcattgcc ctggcatcct 3052861 ttaccgttcc tcaatacgga atgggtctgt ctttccgggt gctgcgtttt atttcgatgt 3052921 tttccgccgc tattttaggg ctatacggca ttattttatt tatgcttgtc gtttatacgc 3052981 acttaacgag acaaacgagc tttgggtctc cgtatttttc gccaaacgga ttctttagcc 3053041 tgaaaaatac ggatgactcc attatccgtc tcccaattaa aaacaaacca aaagaggtga 3053101 ataatccaaa tgagccaaaa acagactcca ctgaaactta atacctttca aggtatttct 3053161 attgttgcaa atacaatgct tggggccgga cttttaacat tgccgcgagc gctgaccact 3053221 aaggctaata cgcctgacgg ctggatcacg ctgatattag aaggtttcat ttttattttc 3053281 ttcatttatt taaacacgct cattcagaaa aaacatcaat acccttcact ctttgaatat 3053341 ttgaaggaag ggcttgggaa atggatcggc agcatcatcg gccttttgat ctgcggctat 3053401 ttcctcggcg tagccagctt cgagacacgg gcaatggctg aaatggtgaa gtttttcctg 3053461 ctggagagaa ccccaattca agtcattatt ttaacgttta tttgctgcgg catttattta 3053521 atggttgggg gcttaagcga tgtgtcgcgg ctgtttccct tttatttaac ggtaaccatt 3053581 attattttgc tgattgtgtt cgggatcagt tttaaaattt ttgatatcaa taatttgcgt 3053641 cctgttttag gcgaaggcct tggacccatt gcaaactccc ttaccgtcgt ttccatctct 3053701 tttttaggaa tggaagtgat gctgtttctt cctgaacata tgaagaaaaa gaaatacacg 3053761 ttcagatatg cgtctctagg atttctgatt ccgattatct tatatatcct tacgtatatt 3053821 atcgttgtcg gagctttgac cgctcccgag gtgaaaacgc tgatttggcc gactatttct 3053881 ctctttcagt cctttgagct taaaggcata tttattgaac ggtttgaatc ctttttactg 3053941 gtggtctgga ttatccagtt tttcaccaca tttgtcattt acggatactt tgccgctaac 3054001 gggctaaaga agacatttgg attatcgact aaaacaagca tggtgattat cggcataacg 3054061 gtcttttatt tttctctctg gccggatgac gccaatcaag tcatgatgta tagcgattat 3054121 cttggctata tttttgtctc cctgtttctg cttccgttca ttctcttttt cattgtagct 3054181 ctcaagagga ggattacaac aaaatgaaaa tccggatttt atgtatgttt atatgcaccc 3054241 tattgctgtc cggatgctgg gacagtgaga atatcgagga attaagctta gtgatcggaa 3054301 tagggctaga caagcctgac gatgaaaatt tagagctgac acagcaaatt ctcgtgccga 3054361 aaataatcag cgccaaggag ggctcttcat ctgatccgac acagctttct atcacaaagg 3054421 gtaaaactgt ccatcaaatg atgagaacct ctgcattaaa gcataagcct acgttttcac 3054481 agcatttgcg tctcattctg ctttccaaaa gcgtgattgc ggatcaaatt ggaatggacg 3054541 ccattattaa ccagtttgtc agagacaacg gaacaaggag gagttcctac gtctttatca 3054601 ccaacggccg aactaaggat atatttaaca tgaatgatga aggcgaaccc gcatccaacg 3054661 tgatatatga tctgacagag aataataagg tgacgatcag aacgatggag ccagttacat 3054721 tgggggagat ctcagaacac ttaacctctg acgattcatt cctcatccct catgtcggta 3054781 aggaaaacgg caagctcgcg ataaacggag cctctatcat aaaaaataaa ttatggcacc 3054841 gggacctcac cccgattgag gttcaaaata tcagcttatt ttcaggcact gtcgagggag 3054901 gcgtcattga cttgaagcgc gatggccatc tcttttctta tgaagtatat tcaagcaatc 3054961 ggaagatcaa gacggcatac aaggacggaa agttcaaatt caccgttacc cgcaatattg 3055021 aaggtcgtct atctgaggac tggaatccca atgaagactc gtttaaggat tcatatatta 3055081 aaagtattga aaagacagtc gaaaaacgag tacacgaaac agtaacgtca tttattacag 3055141 agaagctgca gaaagagatc aaagcggacg taaccgggct gggaaacgag gtcagaattc 3055201 attatcctca aaagtggaaa aagatttcaa gaaaatggga tgatgattat ttcagcaatg 3055261 cggaaataga ctaccgggtc aatgtgattg tcagagactt cggaacgaaa ggcgcaaaca 3055321 aatagcagcc gcctaattca cgagatgatt tcggtgtgcg tacaccgccg cctgcgtccg 3055381 gtcactgaca tccagctttg ataaaatatt cgtaatatgt gttttgactg ttttaatcgt 3055441 aataaacagt tcctcgccta tttctttgtt tgtctttcct tctgcgatca ggcagagtat 3055501 ttcgagctcc cgttttgtaa gcgattcatg cgggagcgcg ttttcacctg agtggcgcag 3055561 cctggataat acttttcccg ccacttttga ctccagcttc ggctctccct tgcttgcggc 3055621 gcggatggca tcggcgattt ctgccgcttt tgaggttttc aacagatagc tgagcgcgcc 3055681 agcttcaata accgggtaca ctttgtcatc atcaatgaag ctagtgagca caataatttt 3055741 cgggtcggaa agctcccggc aaatttgctt tgtagcttca atgccatcca tgccctccat 3055801 gacaaggtcc attaaaatga catcaggcga cagttccaca gcaagccgaa caccttcgct 3055861 gccgtccgat gcttcgccga tgacttcaat atcgggctgc gcctccaaaa aagccgcgag 3055921 ccccattctg accatttcat gatcatcaat caataatact cgaatcacgt tcgttctctc 3055981 ctttttcttc cggaaaaatc gggaccttca cttcgatttg agtgcctttt ccttctactg 3056041 aaatcacttc ggcgacaccg ccgatttcac ttgcacgttc tttcatagaa ttcaagccgt 3056101 atgaggaggc tttcacctgg tccattttaa agccttttcc attatcaatc accttcagac 3056161 ggagctggct gttctttatg cccagaatca cggttacttt tgacgctttt gaatgtctaa 3056221 atacgtttga aagggcctcc tgcacgattc tgaacaagtg gtcttcaaca cccttggata 3056281 tcgctgtgtc ctgtatatcc cactcaatat caatcggctg cttttttcgg aactcgtcca 3056341 aaagctccgt aaggccctcc ttcagccctt ttccttcaag ggtaacaggc cgtaaatgga 3056401 gcagcagcgc cctcatctca ttttgggctt cgcctgccat atgctcgacc atcctgatcc 3056461 gcttgactgt tttgtcatca gcatccttga catgttccag cacggctgat gtcatcatcg 3056521 atatggcaaa gagctgctgg ctgaccgcat catgaagatc tctggccaat cgctggcgtt 3056581 cttctgagat aaccgacttc ttcatttgag cctgccattc cgcacgttca ttggaaagtt 3056641 tctggaggga tgcgacttga agctccacgc gcttcgccat ttcgttcagc tgatcagcag 3056701 ccaggccgat ttcatcatca ccgagcggcg gtatccgata agcgaaattg ccgttttcaa 3056761 aggttaaaat ggattcaatt aatgtatcaa tccttgtctt caaccggttg ccgtacatat 3056821 accctgaggc gaaaccgacg gtcacgctga tcagaagcaa aatcaggata aacggaattc 3056881 cgaaccagct tgatgacagc aaaacaagcg gatcgagccg atagtaaaac atcataaagg 3056941 aaatcaggca aacaaaaagg agcaggctga ttcccgttgt catgcggatg gcgcgccatt 3057001 ggaggctggc aagcattttt tttctcatac gtacttcaca tccacatcac cgataaataa 3057061 ggaaacggac acttttaccc ggcgctttga ctcgctaaaa tcagttgacg cggcatatac 3057121 cttcgtgctt aatccgcttt tcttcgagcc gatcagatta atgtctccta taaaaacagc 3057181 cgagctgaca gccacttcaa ggtccgatgg tacataaata tcaacgttac caatgactcc 3057241 gctaatgacg attgtacttt ctccctcggg aatcatcgct ttagataaat cgattttgat 3057301 atcaccgata aaaccagaga catttaaatc gttcaggtca aacggctgct tcatcatttg 3057361 cagctcaccg ataaaaaagc tgcgcatgtc gggatgtttt acatcttttg gcggctcatg 3057421 atgttctttt ttattgagat tgacctgttt ctcattcggt tcaaatatcg gcttcccttt 3057481 gataagcctg tagccggcgt aaatcagaaa tgcggcaaac gcatagccga ataaattaaa 3057541 ggtgatgctg aagaggtttt tcaaaaatag aaacgcggca aagatataca tgacggagcc 3057601 aagccaatca cgggaatatt ttttaaggaa atagccggca atcagaaaaa agagcggcca 3057661 aaacagcaga tcgcctattc cgataatttg caaaaacata ctgatgccga ataaagcaat 3057721 gatcaatccg agaagctgtt tttttgtcat tcctggtgtc cgcctccttt cttctgccta 3057781 gtgctaccgt atcgctagat ccccgctgtc cgttttgatg tcgattggat gccggccgct 3057841 tccttgcgtg cctgtgatgt gatgctgttc tttatgtcct ttatcagcaa atgaatacgg 3057901 cgaactgacg tcaccgcttg ctgataaagc attgactgca aagctgccat tttggggaag 3057961 gcttacatta gcatcaccgc ttgtcagcgt gacagatacg ggaccggtta cctttttcaa 3058021 tacagcatta aaatctcctg aagtcatttt cacatcaaga gagcctgata catgaaccag 3058081 atttgcgtcc cctgaagcta aatcaatgcc ggctgttttg gagacggtat ttgaaatgga 3058141 aacatccccc gatgatgcct tcactttcag atcttgaatg cggacgtccg tcacgctcgt 3058201 atttccgctc gcagatactg cgttcagccc ggaaagcgca agatggtcat tcccggccac 3058261 agacacgtca ccgcttgagg ttcgtactgc cagatcacct ttataatcat acggaagcct 3058321 gacgataaga gttgaacggt taaatccatt caaaaattga aattcttttt cctttacggt 3058381 cagctccagt tttcttttgt tttcagtaac aaataacttt cctgagtctc ctgaaatgcc 3058441 tgccgatatg tcacttcgtt cttccgctat aatccggaca tccttgctat ccgactcaat 3058501 gaccatgctg tcaatgtccc gcggcgatgc gctggctgaa tcagcttctg tgccatttat 3058561 gaaacctagg cctgcagcaa acacatcttt tacgacgacg gcgaaaaaaa ccagaatacc 3058621 ggcagtgatc aacagtttgc caagcatttt tttcattcgg tttcatcctt ctcattcatt 3058681 ctattataaa ggaaaagctt gcgaattgat acgtgcggaa gggaaggact tgaccgcaaa 3058741 tccttccccg ttccgcttat tcatttgccg cttttgtctg gtctgatttt tgcagtgaaa 3058801 gtgtccgcat tttttcaatc tccgcttcca catcgtctgc gaattcttta cgtgtaagtt 3058861 ctgtgccggc ttccgctgac tttgaataat tcgcgcggat ttccatttct tcaatacgat 3058921 tttcaatacg taaaaattca cgatacgcgc tttcactgtc aattttgtca aatgtcgtat 3058981 tcatatgctc tttagctttc gccgcatttg cccgcgcaat cagcgcctgt tttttatcct 3059041 ttacgtcctg aagctttgtt tcaagtgcag ccagctgctc tttcagatca gccagctgac 3059101 tgtttgcctg ttcataggaa gctttatgct cagccgcctt cccttctaaa tacttcattt 3059161 cagtcagcgc ctttttcgcc agttcttctt cacctgcgtc aaatgcgagc tgtgcctgat 3059221 ttttccgttt gccagccact tcagcggctt cttcatattt tttcttaaat tgataggcaa 3059281 tcgtgtgctg tttcacaatt gtttgctttg cttttgcgat gtcgctttcc atatcgcgta 3059341 catattgatt cagcatcacc tttggattct ccattttatc aagtccttca tgaactgacg 3059401 caacaaacat gtctctgatt ctttttaata ccatacctga ttcctcctaa tatattgata 3059461 ttattttttc ttcaaaaatt cttcccattc gtcatcaaag tgagattggt aggcagcaga 3059521 agccggttca ggatcaaaag atgatacacc gttatcagct gatccgtttt tcatcagctt 3059581 ccagccgtaa tacaccatag cggccgccaa tgcgattccg acgacaaacg gaagtgagca 3059641 gatgagcata atggctccga taccgcccac gatgattccc gtgatggttt ttcccgcggc 3059701 aaaccttttg attcctgcgt atgtcatcaa gctcccgatg gcgagcggga tgataaagcc 3059761 gaagcttcct cctccaaaaa agacggagat cccaaataca attaataaga atccgcctat 3059821 tgttttcttg tttattttca tgcagatcct cctttcgttt tccttgtctt catcttatac 3059881 aagttggaag atatgcaaaa cgaatcagag attgattttt atataagacc ggagtcgtat 3059941 ctcgcaccgg acccattggc acaaaaaaac gccatgcacg aggcatggcg ttttaaaacc 3060001 ctttacagat gaacacttgc ttccctttct ttaattaggt cggacctttc tgctttggcc 3060061 aattttgtaa acagcaagat tccgataccc gcaataattt cgacaatccc accgacagcg 3060121 atcactttac ctgagccgaa agcattagcg gcatacccgc aaatgacagc tccggcaggg 3060181 atcgaaatat ttgagatcat atgtataacg gcgtaaacct gcggctgatc ctcactatcc 3060241 acagacgtct ggataatcgt gtactcagga acattaacag cactgactgc ggcaccaaag 3060301 gtaaaagcag cgaaaaagac gagcggcaaa aaggtattca tcccggtaat aaagaaagca 3060361 aatccttcaa taatgccggc agtgacgaat aacaagccgt acctgtttac cttgactttc 3060421 gccagcacaa accctaataa aaacgcgccc gcggcggtgg tggcctttaa aagcgagtat 3060481 acgatcggct ggccgtttaa atcttccgca acgtatacgg cagagagcgc ttcccatggg 3060541 gcagccgcga aattcataaa gatacagtaa atggcgagcg gatataaaat ctggtgtttt 3060601 ctgacgagcc taaagccgcg tttcagtctt ccgatatatg tgcctctctg tgtaacaacc 3060661 gcagactctg attgagattc aaccgcagtg tacttaataa aaagaacgag aaaacctgac 3060721 accaaataga gcacaagtgc gataagcatg gtataagaag gactaataaa tgtaagaaaa 3060781 gcgccgcata atgtgacagc cccaagccgg acaatttgag cggaggattg cagcacagcg 3060841 tttgcttttt gaatgccctg ttcattgacg atttgaggaa tcaaagcgat agaggcggga 3060901 ttgtaggcag ctccagtagc tgaatgcaca atcataagcg tcatgacaaa ccacagcgga 3060961 gagaagcccg caaaatgaca tagagggata atcaaaacaa tcgccgccct tgtcagatct 3061021 gaaaagtaca tccaaaattt cagcgtggtc tgtttcataa aaggccccgt cacaggcgcc 3061081 agaacggctt ccggcaaaaa cgtgacagca atcaataaag cagtgccgat cgcacctttg 3061141 ccgtcataaa ttaaaaacca taatattgaa ttaaatgcga acatatcgcc ggatatcttg 3061201 actattcttg agaaaaacag ataattgaaa tttctcttcc agatgctatc actttcaatt 3061261 aaattcacca tccatcagag ccccccgttg cctatttttt acatctattt attacaatat 3061321 ctcatttttc catttttcag tcaataattc ataaggttca ttttttgtcg taaaatggga 3061381 aattgacaga gtgaaaaaca aaaaaagccg gcatgtattt gaacacgccg gctttccttt 3061441 tcacttttta tgattcgctg ctgtttcggt cccgaaacac aatggcactt ctttcatatt 3061501 ctacatcgcc aataccgctt cttgcattca caacccgggc ggcggcaaag aaataatcgg 3061561 acagacgatt gagataacgc agcactgttt catgaatctc ctccgatttc atcagcgcca 3061621 ccactcttcg ttctgcccgc cttgtaatgg tgcgtgcgat atggagaagc gaagcacact 3061681 ttgatccgcc tggaagaata aatttcttca gttccggcgc ttctgctgta taggcatcaa 3061741 tgcgcgtttc taaaaaggaa acagattctt ccgttagttt atagtctttt ctttctgtga 3061801 cgattgccag atcgcctccg cagtcaaaca gctcatgctg gatggtcagc agctcggctg 3061861 tcagatcttc aaagccgggc tgcccggaaa gctctgccaa agcaagcccg ataaagctgt 3061921 taagctcgtc aatcgtgccg tagctttcga cgcgtaggct gtccttgtcc gttctgcccc 3061981 cgactaagcc cgtttgtccc ttatcgcctg tttttgtata tagtttcata ccctgaatct 3062041 cctttacaga cttattcaaa caactcagca gcctctttta tacattcagc tgtccctttc 3062101 tttatcaatt ggttcagccg ctgttctatg ttttctgatt gctgagtttg agtcgcggcg 3062161 atgagaatat cacctgtgcc tcctccgtct cccagcactt tcgtccgttc tgcttcggca 3062221 gccataagag ctttgatgaa gaattgatct gccgcatagc cgttaatcaa aatccaaatc 3062281 gaaaagccgg tctgaacgca tatgaaaacg gataactctc cgtcttcata tgttcgatac 3062341 acgaaacggt caagtctttc tgaagaagcc atcgcacacg tctcctgcag ttgaaaaccg 3062401 ctttctgaaa gacaggccgt aagtccttct atcggatctg gctgatctgg cagccgttta 3062461 tggatcagcg tcctgctcca cgaaaaccct gcaccgatag gcgtggagga caatgttcga 3062521 agcgggattt ccgtttgcag aagaatgtca tcacgccccg cttggagcaa tgcttcaaat 3062581 gggatagact gccgcttcac gctatctttt tcaggctgaa tcacaatcat cggtttaggt 3062641 gagctttgat gaaccaaggc ggtgacatct gtatcgtaca ccgcctttat gctttgttct 3062701 gtaacagcat attccggttt ttgcttaggc ccggcggtac cgtttttcat aaacatgagc 3062761 ccatcacagt acaggcttgc ggtgttcaga tcatgaaaaa cgctgacagc tgccaatccg 3062821 ctttctctcg tcaggcgttt gatcagatca agcaggtctt tttgataagc cagatcgaga 3062881 aaattagtcg gctcgtccaa aaataaaata cgcggctgct gcgccaaagc ttgtgccaaa 3062941 tacacccgct gctgttcccc tccgcttagt tcgcgaatcg gcttttgcgc aaaatcggcc 3063001 actcctgttt gctccattgc ttcctgtaca atggcttcac ccttttcagt ctgctgtctg 3063061 aacagccccg tttggaatgg atatctgcca aaggctacag tttcttcgac agtaaaggtg 3063121 aaggcttgat ccattttttg cggcaggaca gccatgattt gcgccagttc cttcggttta 3063181 tagtccgcca gcagttttcc ggccagataa accctgcctt tcttggccgg cagcgtacct 3063241 gtcagcaagt gcaaaagcgt ggtttttccg cttccattag ggccgagaat tccaagaaat 3063301 tctcccttct ccactgttaa gctgacattg ttgattaggc ggctgtcgcc gtatcctccc 3063361 gacagccctt ctgccttcat cataagcttc tccccccgcg atgctgccga attaaaataa 3063421 gagcgaacac aggcgctccc gccaaggacg taatgatccc gatcggcagt tcaatcggct 3063481 caatgatggt tctggaaagc agatcggcta aaacaagaaa ccctgcccca agcaaggcgg 3063541 acaacggcag taaatgccga tggtccgttc cccacaaaag ccttgtgata tgcggaatca 3063601 caaggccgac aaagccaatc gtacccgata ctgccacagc gcttcccgtc aaaagagatc 3063661 cggctattaa aatcatcatc ttcctctgct gaacgctgac tccaagaagc tttgctttat 3063721 cttctccata tgtcatcacg ttcagttccc ttccgtttat aatcaataaa atggttccca 3063781 aaagaaaaaa cgggagaaac aaaataacat agctccagcc cctcattgag acgctgccaa 3063841 gcagccaatg cacaatcgga agcaggttgt ctcctgtcaa ggcgatgata agagaaataa 3063901 atgcgcctaa aaaagagttg gtgatgacac cggtcaaaat gagggtggaa acagacatcg 3063961 aagcatgaac gaggcggctg aagaaaagga ccgccgccat cgtggccagt gccgcggcta 3064021 cactcaaaac cgggagtgta aaccctccga tgacaggaag gtgcaaacct aagaacagag 3064081 tcacaacagc tccgactgaa gcaccggatg acacacctag cgtataggga tcagcaagcg 3064141 gatttttcaa caatccttga aaagcggccc ctgcaataga aagagccgcc cccacaaggg 3064201 cggccagcac aactctcggc agtctgatat tcatcataat attagtgtac atcggatcat 3064261 cagaaccgat agagccgccg aaaccttgat gccaaaagac acgaaaaaca gcgggaatag 3064321 gaatatgcag gctgccgcaa gaaattccta agatgatgct cacggctaaa aatgagaaac 3064381 caatgatata tgcggcataa cgattattcc ttaaacgtat ccgggtaaat gctttccgca 3064441 agttcttcga ccccttcgat cagacgggga ccggaacgtg tcacaagatc agggtccaca 3064501 tcatatacac gatgatgttt cacagcattg atttcgctcc agccatcgcg tttttccaca 3064561 gctttcgctt tcacaccgtc cgttgtaaca attgcatcag gattgagttt tacgatcgcc 3064621 tcgtctgtca tttgcaccca tcctgtctga tccgcagctg cgtttttagc atggatgaca 3064681 tttagcattt cattcataaa cgtatctttt ccggttgtat aaatgtcagg atcaggagaa 3064741 acctcgataa atacgctttt ctcctcgtct tttgaaatgg ttttcgcttt ttcttgaata 3064801 tcctttagat ctgatttcat gcttttcacg agctgatcgg cttttttctc cgccccgcca 3064861 gcttctccga tcatttcgat tgatttgtac acctcggaga atgattgtgc atcattgaca 3064921 gtcagcactg taatgcccgc gtccttcagc tgtttgatgg catccgctga tgctgacatg 3064981 gaagactcat gggccagaac gagatctggt tttagagaaa tgactttttc aacgtttaca 3065041 ttcatatctc cgactttctc aacctttttg acttcctttg gataggtatc gtttgtggtg 3065101 acaccgacca ctttgtcacc aaggccgagt gcgtatgtaa tttctgtgtt gctcggcatt 3065161 aatgaaacaa tcttttttgg ctcttttttg atggttacat cttggtttga cgcatcatca 3065221 atggtgacag ggaacacttc tgttttttgt tttgcctttg aatccttctg atccgcagga 3065281 ttgccgcagc ctgccagcat aacagcagcc aacagaagcg cagcccatat cccggctcgt 3065341 tttttcataa tcttttcctc ctaaacgaac taaaaaagca tctctacgac ggtaaagatg 3065401 ctgtaaacaa cacaaaaaag cctattgttt acacatcatc tgtcctcgca gaattcgtgc 3065461 tgatcaaaca ggcaggtatc ctggctcttg gcgcttggcc aattacagtg gcgggaccgc 3065521 accggctttt accggtttcc cttttaagcc ggctgttgtt cacggaccgg cacctatttg 3065581 acattcgtat ccgtttttcg gagtaattat actatatgac tgacaggctt gtatatgtgt 3065641 cctgaatgac ttttccccat attgtgtatg gaagcaaaat cctcgtaaac actaaatttg 3065701 atcttgtata cttaatacca tcatctatca aaaggaatga ttcttatgga tttacagcta 3065761 aaagaaaaac tcgtcttaat caccggctcg acgtccggta tcgggaaagc cgccgcaaaa 3065821 agctttctgc aagagggtgc ggcagtcatt gtcaacggac gcaaacagga gactgtcgat 3065881 cgcaccattg aagagctttc tggctatgga acagtgcacg gtgctgctgc cgatttgtca 3065941 aaaacagatg aagcagcggc ttttatcgaa aaagtaaatg aaatcggtga tatcgatatc 3066001 cttgtcaaca accttggttt cttcgaggta aaagacttcg ccgatgtgac agatgaagag 3066061 tggaatcaat atttcgaagt gaacgtgatg agcgccgttc ggacaagccg tcacttcctt 3066121 ccaaaaatgc ttgccaaaaa cagcggccgc attttaaata ttgcaagtga agcaggcgtc 3066181 aaaccgctgc caacgatgat tccatactca atgacaaaaa cggcactgat cagcctttca 3066241 agaggaatgg ctgaaatgac aaaaggcaca aatgtgacgg tcaactcagt gctcccggga 3066301 cctacttgga cagagggcgt ggcctcctat atggaaggcg ccgcacaagc agccggacag 3066361 gatacagata catttatcaa agactatttc aaggtcaatg agccaacctc acttattcag 3066421 cgatacgcga cagcagaaga agtcgccaac acaatcgtat tcctcgcgtc tgacgccgca 3066481 tccgccatta acggcacggc acagcgtgtg gaaggcggca ttatccgttc tctgtagtat 3066541 aaaaaaacgc atccgtgttt cggatgcgtt ttttttatac gtctccagca aatggtaccg 3066601 gctgatatcc gcctgtttcc agttgtgctg aaaacaaccc tccagcgtga ggctgctcgt 3066661 atctctcttt ttctgtcatt tgttctgttg ccgttgtaat gtaaagggtt tttaagtctc 3066721 tgccgccgaa cgcgcagcac gtgacatatt tagccggcac gctgattgaa ttgatttctt 3066781 ttttctgaaa cgggtcaatg tgaacaacgc ggctgccgcc aaacagcgcc acccacagca 3066841 tgccattttg gtcaattgtc atgccgtccg gcaatccgtc tgactgatca aaacgataga 3066901 caggttctgg attcgaaaca tctccgcttt gaggatcata gctgtaacgt acaatctcct 3066961 gggtcggcgt gtcgatgtaa tacatcaaat tccgctcgcg gtcccaatcc aaaccgtttg 3067021 aggtggagac ttgatccttg attttgacaa gactgccgtc tagattcaaa cggtacagcg 3067081 acgcctgttt ttgctcgcct tccatgctcg tcgtccccgc ccaaagcctt ccgtacgggt 3067141 cacatttagc atcattaaat ctcaggctct catgcatgtc cttcggctgt ttaatttttt 3067201 ccaagctgtc atcccgaaga tgatacaggt aaaacccgtc cttcatcgtc ataatcagtt 3067261 catcctttga atatttcgca agcgccgtca caaaggattt gaatttgatt gatcggttga 3067321 ttttttcttc agggtcaaag atgtggagct cgctccccag gatatcaacc caatataagc 3067381 ggccgttctc ttcatcccat aacgggcctt caccaatcac tgcccgagtg tctgcttcca 3067441 atactgcatc catgtgttac acctctttag cttcagtcta tatattgtta ttcccggcaa 3067501 agaggtgtcc aaaccacttg atgtttattg ttttttaaaa aggatggtaa tgaccgttcc 3067561 aatgttcgtt ctgctgttca catggatcgt tccgttatgc agatggacaa gctccttggc 3067621 aatcgcgagc ccgagacccg ttccggcagt tgaatctttt gtgttcgtcc ctctgtagta 3067681 gcggttaaac aaatgggtga tcgtttcttc atccattcct ttcccattgt ccttcacttt 3067741 taaagaaata tgattttttg tttgctccag aatgacttga atctctgttc ctttgccgtt 3067801 gtgcttcacg gcattcccaa ggaggttttc taatatgcgc ctgaaccacg cttcatcaag 3067861 ggcaaattca atatgctctt ctttggatac aaacgagata tcatagcctt cagaaaacgg 3067921 atttttctta aaatcctcaa tgacattttt aaaaaacggg ataaggctag tgagctttct 3067981 ctcaatagga agagcatcat ttttcaggcg atacgttaaa tttaagtctt caatcagctt 3068041 agacatgtat tcagattttt ctctgacaac ctgccccatt tctttcactt cttccggcga 3068101 ccagtcatac tgcttcgact cgagcatcat gctgtagccg taaatgctgc tgagcggtgt 3068161 ttttaagtca tgtgacaaac cggcaatcca ttcttccctt gtcgcctgga ttttttctct 3068221 gtttctttta tcccttctca gcgtttcagt cagctgatcc attgattcaa atatctcacc 3068281 gaagaagcgg tacggctgtt tgatttttcc ctttttattt ttgctgacag gacggccttc 3068341 ccggtttctg ggctcctcaa gcttcccttt tgacagattg accagccatc taatcgtgtg 3068401 aaaaatcggc agcccgaatc ggaacatata ccaaacggtc atccaaatga tatacatgaa 3068461 caaaacggcc atcacgagaa acatcgcttt taatacaacc ttcaggaatg atttgttaaa 3068521 ctcctgatcg gttacataga ctgggttcgg caccgtagcg accatccatc tgtctttatt 3068581 gaggatctta acggaaattt cccgcttata gttccaaggc ttagagctgt atttaagcag 3068641 ctccagctgg ttcatcgttt ttctctcgct ttttgtgctg ttgatgctgt cgagaatctt 3068701 tccattgctg tctaacaggt aaatggcgcc ttttttccgt ttaatatagt cgatggtact 3068761 agacttatag tgcgctagtg agtctatctt ttgttcacgc ttttcaacgg aagtcaggag 3068821 ctgttcactt tttgatttcc agccggacaa tagaagatac gacttatctt caatattgat 3068881 ggcccaataa ttcagtttat agttatgaag ctttttggtt ttataaatag acaaaagctc 3068941 tttcttggta taggtgcccg gcacgtcttt tggcacgccg taggaataat cagtgtttcc 3069001 ttccgaatca atgatttgca tccagccgtg ctgtttatca acagatttct tcaggaaatt 3069061 atccacttcc catgtcccgt cttcgtttac atcgagatat gcctcaagtg tgtcggtcgt 3069121 tgctttcgtc agccctgaat tggattccgc atcgctaaaa cgggcgtcta aatagaaaaa 3069181 cgatgcaaca agcataaccg taagcagcag gatcacaatc agcatctggc cgaaaaagtg 3069241 aaacaaaaac ttccatctta acctcatgac cgcttgcctt caggatttgg gataaaacga 3069301 tagccgagac ctcgaacggt tacaatatac tccggattgc tcggatcgcg ctcaatcttc 3069361 tccctaagct tgcgaatatg aaccatgacg gtgttgttgt caccgtagga aggatagccc 3069421 catacttttt catatatttg atctttggaa agcaccacgt tagggtgttc acaaaaatac 3069481 tgcaaaagct gcagaagctg ggctgaacag gcaacggctt ccccgcctac gatcaactcg 3069541 gcattttgcg gagaaaaagt aaagtaatca tatgtgtagg tttgatttga actcgtttct 3069601 ttcgattgat atgtacgctt gagatgcgct ctgatccgcg ccgctaattc cagcggatta 3069661 aatggttttg tgatatagtc atcagctcca accgcaaagc ccgataattt gtccgcgtcg 3069721 gatgatcttg ccgtcaggaa aaaaatcgga gcgtctgaat actctctgat caatgtgcag 3069781 gcttcaaaac cggacattcc gcccatcatg acatccagca caatcaagtc aaccttattg 3069841 gccttcacaa cgggaatcgc ttcttctgcg cttgccgcat ccagtatatt tcgataacct 3069901 tctttttcga gaacgcgttt gatcatgtcc acaatcgctt tctcatcgtc tacgattaaa 3069961 attgacgcat tttccacttt tatgttcctt tctgtcactg tttttttcat cttatcatta 3070021 tatcgtttat ttatggtaca tttttgaata cattggagcc ttggcaaatc aaaacagcaa 3070081 aaaaggagca aacaagcgct cccttttgat gttttttcat atgaaaatat tatgagttct 3070141 catctaccat gtacaaaata aactcccaaa accccggtac atcctgacat aaaagcatat 3070201 cagccttttc aaacattttg atcttcagct cttgctctaa atcttctctt tcttgatagg 3070261 acgtattgct gagttttttt ctgatcatcg gtgaaaagca tgcaatcagg tgctcaatgt 3070321 cataagtctc gtctttttgt ttcttttttt gttcaaactg gccgtccaca gcttactttt 3070381 cccccttttt ttgcgccgct aactgctttc tgatattctc cagccccttt ttatgaatgt 3070441 tggagatgtt ttgtcgggac tcccctaatg aatctgcaat ctcctgcatc gtggcaccgt 3070501 gaagatagac tttcgtcagc acactttttt gtttgtcagt cagcttctgg atcgcttggt 3070561 agagctggta atcctgtaca tgctggctca aatcatcctg cctgtctaaa aattcttcaa 3070621 atgcatcgct acctgtttcg gaagaaagcc gatctcccgc ctccggatga tcaaccgtca 3070681 gtggataccg tttttggttt ttgcgaaccc gcttatcaaa atcaatagaa aagatgcgaa 3070741 tcattgaatt catatacttg acgatgcgga tttctttata aaattgctta aatagctcgt 3070801 ccaatgatct tgcatctttt tcgttagggc tttccattac gtttttgaac aaacggtaat 3070861 gctgaggatt gctcaaaaaa tgcttcacga tgggatgctt cattatctcc ttacattttg 3070921 accgtaaaag actttgatag tccatcaaac cgcctcccta ctaaattaaa tgaaggaaag 3070981 caaaaaaaag taaactacta ctttccgcct agtgtcttcc aaaatacttt gcagcagttt 3071041 acgttttatc ggttttcctc acttacatac atgactgcag aaaaagaagg gaggtatttt 3071101 cctatggatc aggtttttat agaggaagtc gtaaaacaga tcggcaattt ggggtttccc 3071161 gcgctgattg caatgtatct gctgacccga ttcgaaaaga agtttgatca actaatagaa 3071221 ctaatgacag aactgaaaga tcatgcaaaa aaataatttt tcaatcgaag ttgacttttc 3071281 actggttttt ttcacttaac aaaacagaag ggaaaacgaa aggcctttca ccttctcttt 3071341 ctgctatcac atttaaatgt aaggaggaaa catttcatga aaaaacaaaa tgacattccg 3071401 cagccaatta gaggagacaa aggagcaacg gtaaaaatcc cgcgcaatat tgaaagagac 3071461 cggcaaaacc ctgatatgct cgttccgcct gaaaccgatc atggcaccgt cagcaatatg 3071521 aagttttcat tctctgatac tcataaccga ttagaaaaag gcggatatgc ccgggaagtg 3071581 acagtacgtg aattgccgat ttcagaaaac cttgcatccg taaatatgcg gctgaagcca 3071641 ggcgcgattc gcgagcttca ctggcataaa gaagctgaat gggcttatat gatttacgga 3071701 agtgcaagag tcacaattgt agatgaaaaa gggcgcagct ttattgacga tgtaggtgaa 3071761 ggagaccttt ggtacttccc gtcaggcctg ccgcactcca tccaagcgct ggaggaggga 3071821 gctgagttcc tgctcgtgtt tgacgatgga tcattctctg aaaacagcac gttccagctg 3071881 acagattggc tggcccacac tccaaaagaa gtcattgctg cgaacttcgg cgtgacaaaa 3071941 gaagagattt ccaatttgcc tggcaaagaa aaatatatat ttgaaaacca acttcctggc 3072001 agtttaaaag atgatattgt ggaagggccg aatggcgaag tgccttatcc atttacttac 3072061 cgccttcttg aacaagagcc gatcgaatct gagggaggaa aagtatacat tgcagattcg 3072121 acaaacttca aagtgtctaa aaccatcgca tcagcgctcg taacagtaga acccggcgcc 3072181 atgagagaac tgcactggca cccgaatacc cacgaatggc aatactacat ctccggtaaa 3072241 gctagaatga ccgtttttgc atctgacggc catgccagaa cgtttaatta ccaagccggt 3072301 gatgtcggat atgtaccatt tgcaatgggt cattacgttg aaaacatcgg ggatgaaccg 3072361 cttgtctttt tagaaatctt caaagacgac cattatgctg atgtatcttt aaaccaatgg 3072421 cttgccatgc ttcctgaaac atttgttcaa gcgcaccttg acttgggcaa agactttact 3072481 gatgtgcttt caaaagaaaa gcacccagta gtgaaaaaga aatgcagtaa ataaaagact 3072541 tgcggcttgc agagagcact cgttctctgc aagccttcat aaggagctga accagtgaaa 3072601 catcaaaacc cttcaaaacg cttattgcgg ctctccataa agtacttgct ggccgcagca 3072661 gcagtggtgt tgacctattt tgctgtcatc tatatattgt tttctttagc gggaacgagc 3072721 taccgctcag cagctcatgt cctgcttttt gccgtggtat tccttgttct cggattatgc 3072781 tttgaaccat ttgaacggct gatgatacat agctttacat ttttcaagac aggaaaacgt 3072841 ctattcattc tccttgctgg catcgtacag ctgctgtttt tgtggatgac tgctcataca 3072901 acagaccaat tgatcagcga catctggctg tccaccacag aagaaatgat tgtcgcagcc 3072961 gtttttttga ttttagacaa atgcaactcg gctcttccca gctaaaaaaa gaacgcattc 3073021 caattggatg cgttcttttt attcatagcg aagcgcgtct acaggctgaa gcttcgaagc 3073081 cttgatagac ggaagcaagc cgaagataat gccgactgcc attgaaaaga tgagtgctcc 3073141 gacaacagct ggaatggaga cgataaaagg catcggaaaa atgaccgtca gcagcttggc 3073201 gatgccgaag cccgccagca caccgagtat tccgccaatg cttgtcagca cgacagcctc 3073261 ggttaaaaat tgaaataaaa tcacacgccg cttagcaccg agcgctttct taattccgat 3073321 ttccctcgtg cgctccgtta cggaaacgag cataatgttc atgacgccga taccgcccac 3073381 caaaagtgaa atactggcga taccgccaag cagcaatgca aatgactgat taaaggactc 3073441 cacttcctgc gcgatctcct gaagatccat tacactgtac tctgcttttt ccagctcagc 3073501 ttctgacagt ccctgattta aaagatctgc agccattaca cccgcttctt ggatatgctc 3073561 agaagaatca gcctgcacgg caatctgcgt tggcgcgtca aatccttcaa taagcggcca 3073621 cacttttttc ggcacgtaca aaaccgggtt cgcatagtcg ccttcaaaca tgctttcctg 3073681 ttgatttttt tctttaaaaa cacccacgac cttaaacggc acaccattca tctcaatgct 3073741 tttatgcaga gcttctccgt ctggaaacag ttcatctctg acagcttcat tgatcatcac 3073801 tacttggtgt gtgctgttta aatcgttttc cgtcagcttt ctcccttcgg ttattcggat 3073861 tggaaacatg tcgaagtaat catcgtccac tccatacact tggggatacg aaacgttagt 3073921 taaatgaaaa acgctcgcgc cttctgacaa gtaatataag gataatcctt tgaccatcgg 3073981 atctgatttg atcgccttta ctgtttcttc cgctacaggc ggcgcggacg catacgacac 3074041 ctgagggccg ccgctctcct cttctccgcc agacggctgg tagacaacat tgatggcgtt 3074101 gtttcccatg ccgatcatac tttgctttaa ctgctcactt tggcccttca gcattgaaac 3074161 aatcgcgatg attgccgcta tgccgataat gacgccaagc attgtcagaa tcgatcttaa 3074221 tttatgagag aaaatggatt gaaaggagat tcgaatatgt tcaagcatgg ctgatatccc 3074281 ctctctcatc taataccaac tctccgtctc tgataaaaac ggttctgtca gcttttttgg 3074341 cgacgtccgg gtcgtgggtt atcataataa tggtcttgcc ttcccgatgc agttcagaaa 3074401 acagtgccaa aatttgttca cttgatttgg tatcaagcgc cccggtcggt tcatcagcta 3074461 aaataaacct cggctgattg acaagggccc tcgctatcgc cacccgctgc ttttggccgc 3074521 cggacagctt aggcggtttg taggagaccc tgtcttttaa tccgactttt tccagcgctt 3074581 catatgcccg ttgccttctc tcttttttct tcactttatt gtagatcatc ggcagctcga 3074641 cattttgcag cgcggtgaga cgcggcagca aatgaaaagt ttgaaacaca aacccgattg 3074701 attcattgcg aatttcggct aaagccccgt ctttcccttt caatatatcg atctggtcaa 3074761 gcgtataggt tcctgaggtt ggcctgtcca aacagccgat aatattcatt aacgttgact 3074821 ttccagaacc ggaaggcccc ataatagcta aaaactcccc cgcctgaacg gtcagattga 3074881 tatgtttcaa gattggaact tcttcttttc ccagcttgta cgacttcgaa atattattca 3074941 gtgtcagcat tgactgtaac ctgctttcct tccttgaccg cgggatcagg atagatcaca 3075001 taatcttccg gcgtcaggcc gctcttaatt tccaccatgt cattttcatc agtctctccg 3075061 atttcaacag gctgcttaac cgctttgtga ttctcatcag ctttccatac gtacggttcg 3075121 ccgtcatcct gaatgaccat gtcggacggc agcttgatcg tgtccgcatc agcattatca 3075181 ctcatcactt cgatgttgac atgatagccg acttcaagac ctttatggct gtctaataaa 3075241 atggtgaaag gatagttaga ggactgggga ttcatttctt catcagcaaa gctttctgat 3075301 tcttcaccct cgcctgctcc cgctggaagc ttgccgatcg aggtgacctt tcctttccac 3075361 tcgccctcac cgcctgtttt cagcgtgacc ctgactttgc tgcctttttt gatcgtgtcc 3075421 attaacagct cattgatttg gcttttgacc agatatttgc ctgtcgaaac aatctggata 3075481 tacgggcctg ctgcctggtc gcctgttgca ccgtcagcga tatcctgatt gacgctttga 3075541 acgattccgt catgcttgct tgtaatgaca ttggaacctt tgtttttcgt caggccagcc 3075601 agttcttttt gatgctgctt cagttcaagc tggcttgttt tcaaatcgaa attggtttga 3075661 tcaagttcat cttgaagctg gtttttctct tcttttcctg caactttcag ctttttttcc 3075721 gtttccgtta ttgatttttg caaacggttg atttgcagat ttgtcatttc aatttgcaaa 3075781 ttggcttgct ccacttcatc agaatgatcc tcgccctcat actcaaaaag cttatcgccc 3075841 tttttaacct gatcgccttc tttgacgtat gtttttttaa tgctgccttt ttctgaatct 3075901 atgtatactt tctgctgttt ctcaggttca acctttccag aaaacgtttg gcctgattct 3075961 gaatctcctc ccatgtatac cgcgaccgat tcagcatagg gctccgatga tacggcaact 3076021 tggttcatgt gagtaaaaaa gtaaaaaccg ccagcgccga tcccagccaa tacaagcaca 3076081 ccggcacata tcgcaccgcc aataagccat tttttcttct tggacacaac gatctcctct 3076141 ttctgtaaac tatgtaatat tttcgaaaca ttctaaccaa tattatctat taattcaaaa 3076201 agacttgcaa tccttttatt gaaatgacgg aatcaaatag aaaaattgta ttttcaaagc 3076261 cgaataaaaa aaatcccggc ttcaaaccgg gattttttca tacagtaact agctcttttt 3076321 catttttaat caagtcatat gtcaagcata caggtttatt tgtacgggga tcagtcacga 3076381 tttcggcatc aatctgaaat acctgcttca aaatgtctgg tgtcatgacc tccagagcag 3076441 ttccttcctt gatgaccgtg ccttttttga gcgcgatcat ataatgagaa aaacgagctg 3076501 catggttaag atcatgaatg accattaaaa tcgtccgccc ttgctctttg ttgagtctgt 3076561 caagcagctg cagaatttca agctgatgtg caagatcaag atacgttgta ggttcatcca 3076621 gcagaagcag ttccgtccct tgcgcaagcg ccatggcaat ccacacacgt tgacgctgtc 3076681 cgcctgacaa tgcctcaatc ggccgttcag catattcagc catgcctgtt tcttcaagcg 3076741 cccatttgat aatccggcgg tcttcgtcat ttaatctgcc gaatcctgat tgatgcggaa 3076801 acctgccgta cgacaccaat tcgtgcactg ttaggccgct cggcgcttca ggtgtctgtg 3076861 gaagaatcgc catatctttt gcaatgtcct ttgtagacat tttatgaatc gctttgccgt 3076921 ttaaatagac ggcacctgca tgtgaacgca taattctgga cattgttttt aaaatcgttg 3076981 atttcccgca gccgttcggg ccaattaagg tggtaatttt ccctttagga atcgatatat 3077041 ttaaatcctc tacaatcacc ctgtcgccat aaccgattcc aagctgttcc gttgataatg 3077101 aattcatatt cggccccctc ctctaattcg ctttcatcaa taaataaata aagtaaggcg 3077161 cacctagcac ggaaatgaca agtccgaccg gaatttctga tggtgccaat acatttctcg 3077221 ccagcgtatc agcaagcaaa aacaggaatg agccgatgaa ggcggagacc ggtatcagcg 3077281 tctggtgacg tggaccggtc agccttctag ccacatgcgg cgcgatcaat ccgagaaacg 3077341 caatgccccc cgcagctgcc acgcatgaag cggcaagagt gaccgctgcc agaagaagaa 3077401 tccgtctttc cttttcaaca gcggtgccca gcccggtcgc caattggtct ccgagctgca 3077461 taatgttcaa atagcgtgcc ttatataaag taaacagaag caagatcaca atccaaggga 3077521 gaatcgccca gatcatattc cagttcgccc cccatattga gccggatatc caaaccgcgg 3077581 cttgcataaa atcatgaggg tccatcttga gctgaaaaat cagcaacagg gcgttgaatc 3077641 cggcattcac ccctatgccg actaaaatca gccgaatcgg tgtcacgcct tttttccatg 3077701 ccagaatata aatgagaaac gcagcgagga ttgctcctgc caaagcactg aacggcagca 3077761 taaatgttcc gaaaaagcta agatctgaag ctgacccttg aaaaaagtat ataaaaagca 3077821 ctacagcaag tgaaccgccg gcgttaattc cgagaatacc aggctcggca agttcatttt 3077881 gagacacgct ttgcaaaatg gctccagcta cggagatccc tgctccaaca agcaaagaaa 3077941 ggatgatccg gggcagcctg aactcaaata agacaagttc atcacgcgcc gttccttggc 3078001 cgaaaaagac ctgaagcgtt ttaagcggtg caattttgat aacgcccaaa ttgagactga 3078061 taaaaaagac caccacgata agcaaaaagg tcacagccat tacaatgagc ggtttgtttg 3078121 tttttgtttt cattacagcc ctctcctttc acgacgtgcc aaataaaaga aaaagggaac 3078181 gccgataaga gaagtcagcg cgccgacagg cgtttcaaag ggcgcattta cgagtctggc 3078241 cgctatgtca gcaaaaacaa gcaaaacagc accgagcacc gccgagcaag gaatgatcca 3078301 ccgataatcc acaccgacca aaaaacgggt aatatgcgga atgatcagcc cgataaatgc 3078361 aatggtgccg gcaatggaaa ccgcagctcc ggtcagaatt actacaataa gcatgccaac 3078421 cagtttcacc gctgatgtat attgtccaag cccttttgcc agatcgtcac cgagacttaa 3078481 cactgtaaca gaccgggcga tgaaaaacgc gagcgttaaa ccgacagccc ctgcaataag 3078541 caaaagctgg acccccgacc atttcacacc cgctaccccg cctgcgtacc aaaagctgat 3078601 atcctgagcg acatcaaagc ggattgcaat ggcagttgaa atgccggtaa agaaataagt 3078661 aactgccgta cccgccagag caagctttac aggcgtaagt ccgccccttg aaaacatgcc 3078721 tatgcccatt accgtcgatg cccccagccc cgctcccgca aaggaccata gcacaagccc 3078781 cattgcagaa agtccgggaa aaaaggcaaa cgcaatcgaa accgcaaacg cagagcctga 3078841 tgtcacaccc ataatcgaag gctctgccaa agggtttctc gtcatcccct gcatgattgc 3078901 tcccgacact gccaacaatg cgcctacaag cgcggcagcc gccgttctcg gaagccgaag 3078961 atcatgtata atttggtgag atgtctttgt cggctgataa tgaaaaatgg cctcccatac 3079021 agtgcgcaaa tgaatatccg ctgcacctag ggatatggat aaaaatgcgc caaggcaaag 3079081 caggcataga cctgcgataa ggacgatgac cgcgccatat gtccttgacg tccattggat 3079141 ttcttctgat gcagtccgta tatttttatg ttgactcaac tgccgtactt cctttctgtt 3079201 actgataatg attatcaatt gctgtttcag tatatcactt ttttcagctg atttaataga 3079261 gtgttttgaa caaaaatgaa aatgcatttg caaaaatatc gtgtcaaccg gcacttgcag 3079321 tggtataatc acagatgata atgattctct ttttcatcta tcttttagaa agaaggtatg 3079381 agatatgacc catatataca agaaactcgg agccgcgttt tttgccctgt tattgattgc 3079441 agcgctggca gcctgcggga ataactcaga aagcaaaggt tctgcctctg attcaaaagg 3079501 cgcagaaacc tttacataca aggctgaaaa cggaaatgta aaaatcccga agcatcctaa 3079561 acgggtggtt gtcatggcag acggctatta cggctacttc aaaacactcg gcatcaacgt 3079621 tgtaggtgcg cctgagaatg tatttaaaaa cccttactac aaaggaaaaa ccaacggcgt 3079681 cgaaaacatc ggagacggca cttcggttga aaaggtcatt gatttgaacc ctgacctgat 3079741 tatcgtctgg acaacacagg gcgctgatat taaaaagctt gaaaaaattg cgccgactgt 3079801 cgcagtaaaa tacgataagc tcgacaacat cgaacagctg aaagaatttg caaaaatgac 3079861 gggaactgaa gataaagctg aaaaatggct ggccaagtgg gataaaaaag ttgcggccgc 3079921 taaaacaaaa atcaaaaaag cggtcggtga caaaaccatt tccattatgc aaacgaacgg 3079981 aaaagacatt tacgtatttg gtaaagactt tggaagaggc ggaagcatca tttacaaaga 3080041 cctcggcctg caggctacaa agctgacaaa agaaaaagcc attgaccagg ggccaggtta 3080101 tacaagtatt tcattagaga agctccctga cttcgccgga gattacattt tcgcgggccc 3080161 atggcaatca ggcggtgatg atggcggcgt ttttgaaagc tccatttgga agaacctgaa 3080221 tgccgttaaa aatggccatg tatacaagat ggatccgatc ggattctatt tcacagaccc 3080281 gatttcatta gaaggacaac tggagtttat tacggaaagc ttgactaaat aaacaaaaga 3080341 gccgcctgcc cgcggctctt ttgcttattt ataaggaacg gctcaatttg aatcatatcg 3080401 gatattttct ttgagccatt catattaagc tgcatcctca tcacgatcag tttttttatg 3080461 ctggagagac tgaaaaacgt tttttgcata tttaacgaac ggattcctaa caggagaaat 3080521 tgtgatttta taaaaaagac acctgagcaa atcaggtgtc ttttcattat gcttgttttt 3080581 ctttctggaa cttgttactc acaaatggat aaacgattaa gccgacaaag aataaaccga 3080641 tgccgagtat aaatgtcgtt aaatctgctg tgcctgttac gataacaaac acggagtatg 3080701 cacacgccag tatcgcgatc aatccgtctc ttacacggga gcctttcagc tggtcatacg 3080761 tttcaccttt gatgactacc ttcaagctgt agattgcaga taccagatac ggaattaaat 3080821 atgcgagtgt agccgctgtc gttaaaaatg taaatgcgtc acttattgtc cgggaaataa 3080881 ccgagaaaat gaagacctgt gacatgacgt ttgtaataat gagtgcaatg accggacttc 3080941 cctttttatt cgtttttgca aaaaatgccg ggaaatctcc tgctttagcg gcttggtatg 3081001 gcacctcaga gccaagcaaa atccagccga gcatcgttcc gaataaacaa aggatagcca 3081061 aaagcgccat aatcacgctt cccgcgtttc caacaatcgc atagagtaca tcaacaaatg 3081121 gtttttcaga gccgacaagc ttatcatgcg gcagaacacc catcgtaatt aaagtcacaa 3081181 taatatatat gctcaaggca atcagcaagc cggtaattgt cgcacgtttc acatcacgct 3081241 gagagcgcgc acggccggac aggatcaccg cggattcaat tccgacaaac gcccacagtg 3081301 tagaaatcgc agcgttatga acctggccac caattccaat gcttgtgccg ttttctcctt 3081361 gaaccgggaa ataaaaatga ccgaataatg acgtttgaaa cacaaacaaa ccggcaacga 3081421 taaagaagac aaaacctaat actttagaaa gcgttgtgac aaagtttaat ttacttgcgc 3081481 cgttaatgct ggcaacaaga atcgcgtgcg ttccccataa caagatcgta catacggcaa 3081541 acgtcagtaa ttggccgagt gtcacctctt gcccgccgat cgaaaacatc tcacgtttat 3081601 caaccaagat cgggaagaac gaagtcaagt aaccggcgag acttgtgatg atcgccacgt 3081661 tactgatcca gctcgccacc cagtagcccc acaccattgt gaaaccggca gcgttgcctt 3081721 ttttcgggtc agaaaacagc gctcttgcat aactttgcgg tcccgctgtc agttcaggct 3081781 tgcgaatgga caagtgtccg aacacaagtg caatcatcag cacgccggca cctgtcaaaa 3081841 gccaggcgga cgtagctcca aacggactcg caattgaagc aagcgagctc ggcaaggaga 3081901 aaattcctga tccaaccata tttccaacga caaacgccgt taataaccaa aaaccccatt 3081961 tttttgtctg ttccattcca gtacctccat gattctttgt acggaccaga ccccgagatc 3082021 atataaacgc aaaaaaagcc tgaacaaaag tccatgctta aagaaacaca cacccttgat 3082081 ctccggatag ccctccgcga aaaagcacgc ggcagtcctg cacttattca gatacagtcc 3082141 cagcatagag aaggatcggc tttctccaca cttcggcgct gatgcctttt acacatgttt 3082201 aacagcccct gtcagcctag catgtgtgac tcatcatccg cgcaacctct acctcactga 3082261 gaaagagtga ggatttaatt attcagttac tcccagaagg ttatcaaaga aaggatgatc 3082321 tgtcaaaggg aacagatgga aaatacggat agagccaagc cctatccgca tgtggttatc 3082381 gattattttt ctttttttgc acagcttctt gaagcggatc atcttttaga gctgaaccag 3082441 catcttcaag agctccttgg attacgtttt tttctttttc ggaacgtttt cctttatctt 3082501 tattaaagaa acccattcgt atcacctctt ttaaaaaata ggtacatgtt taagatgcct 3082561 ttttcctgaa aaattatgcg ggatattttt tatcgtccaa agtcctgttg atcaaacata 3082621 cattctcttg atatatttgt aattcagaga ttttttgcaa aagataaaag gagaagcggc 3082681 aaatgacagg aaaaacacac atcatgggag gcatcgcttc ttgtacggca gcggcttatt 3082741 attatggatt tgatccagtg cttatggctg cgtcaggcgc ggttggagca ttaatacccg 3082801 atatctgcca cacacaaagc aaaatcggga gaaaatttcc tattttatcg aaagtggtca 3082861 gctccgtttt tggccatcgc acctttacac acagcctgct gtttatgctc atcatgtttt 3082921 ttatcacttc tacatacatt ccagataaaa acatatcagc cggcctgatg atcggaatgg 3082981 cgagccactt gattcttgac gcttggacgg tgaacggaat caaattatta ttcccttcca 3083041 cgatccgcgt tcggcttcca ttatatatga agacaggcag tttttctgag cagctcgtgc 3083101 tagccggcct gacccttgct tcatgttact acttttatat gctgtttcat ggccgcatgt 3083161 tttaaacatg agtgctgaga cttgtctgaa ccggctgttt ttagtaggtt ttacttaaga 3083221 agcatttcat gcagatgatc aagaaaacgt gaggagtcat attgatgaaa ggaacctttt 3083281 ttcacaatca gcggttttta tgtttttcga tcttatttat gtggatcaaa acgtatgtga 3083341 tatataaact cggctttgat ttgcaaatcg atactctgtt ggaggagcta atgctgctgg 3083401 tcaacccgct cagctttatt cttcctttat tcgggatcgg cctgtttcta aaagaaaaca 3083461 agcagcgggc ctttttgctg attgccaatt tggttctgac tgttatcttg atctctaata 3083521 cgatttttta cggcttttat atcgatttta ttaccatccc ggttttattt caggccagca 3083581 acatgagcga tatgggcagc agtgtaaaag aactgttcca tcctctgttt atcgccctgt 3083641 ttgtggattt ggtttttctg ctgttgttcg ccagaaaaac caaacaccca cagacaaaag 3083701 ccgctcccca cacgatcaaa cggtactatg cagcttcctg cggaatgctt ttatgcacac 3083761 tggcacttgc agaagtacag cagccgaagc ttttggcaca ttcttttgac cgggaaatgc 3083821 tagtcaaaag catcggcctg tttcagttcc atatttacga tacaatttct cagactgtta 3083881 atatcagcgc gaaagctttt gccgatgaag acagtataac tgccattaaa aactacacag 3083941 aggctgatta cagcaagcct gatcaaagca aattcggtct tgcaaagggg cgcaatgtca 3084001 tctttgtaac acttgagtcg acccaaagct ttgttctgaa tgaaaaagta aatggaaaag 3084061 aaattacccc atttatgaat gatctcataa aaaaaagcta ttcctttgat catttctatc 3084121 agcaaacaga acaaggcaaa acatcagatt cagaatttat cgtcgctaac tcactgtatc 3084181 cctcccttag cggcgccgtc tttttcacga aaagcgacca tcaatttcat acgatgtata 3084241 aatcgctgaa gcagcacgat tattattcag ccgtctttca cgctaaccat aaaacatttt 3084301 ggaacagaga tgtcatgtac gatacatttg gcattgaccg cttttttgat gttgatgatt 3084361 ttcatgtcac tcccgggaca tcgacaagct ggggcttaaa agacaaagaa tttttagagc 3084421 agtccgccaa aaagctgaaa agcctaccgc agccgttcta cagcagtttt atcacgttaa 3084481 cgaatcattt tccgtttgag attgatgaaa aggatcagct gatagatgaa ttcgattcaa 3084541 gcagtgatct gttaaaccgc tatgtgacca cggttcgcta tgaggatgaa gcattgaagc 3084601 attttatcaa aaaactgaag gacgaaggct tatacgaaaa ttcgatgatc gtatttatgg 3084661 gagatcatta cggcatttct gaagcccata acgaggcaat ggctgagttt ttagggaaag 3084721 acgaaatcac accgtatgac aacgttcagc tccagcgggt gccgtttatc atacatatcc 3084781 cgggaatcac cgatcaacag ccggaaacca tccctgatgc cgggggacag gtcgacgtca 3084841 ggccgacgct gatgcatttg ctcggcgttg agacaaaagg cgatatccaa ttcggcaatg 3084901 atttgctgtc gggcgaccgc accccattcg ccgttctgcg aaacggcagc tttattacga 3084961 acgattatgt atacacaaag aacacgtgct atagccaaaa aacaggtgaa gtgctggaag 3085021 atcaggatgc gtgcctccct tacaaggaga aagcaaacga agaactgtct ctctctgata 3085081 aaattttaaa tggtgacctg ctcaggtttt ccgaatgaaa aaatccctct atcaagaggg 3085141 attttttacg tttccaatat caccttgcca gtcagcttcg tttcatagcc gtttaaatga 3085201 gacagattcg ccttgtagtc ctcagaattc aaaatctcct tcacggcttt gagcaactgc 3085261 tcattttttt tcaaaacaac gatatcatat tgttcgtcga tgagcgggat aaaatcaaca 3085321 ctgcccatat gtgccgcgtg ctgtgccccg attcccgcgt cagcctgtcc gcttgaaact 3085381 tgtgaagcgg cagcgtaatg atcagtcacg atatcgccat atcccactac atcagccgga 3085441 ttcacaccaa gcaagccaag ctgttcatca aggagcaccc ttgcgccaga acccttttcc 3085501 ctgttgatga tccggatatc ggctcttttc aagtctttcc agccttgaat gtttttcgga 3085561 ttcccttttt gcacatacag tcctgctttg cggagaacga cattgatgag acaaaacggt 3085621 tcacctgtca aaatccgttt tacataaggc gcgttatact ggcccgtttc tgcatcgtac 3085681 aaatggaggc tgacaatgtc acacttgcct tgatacatat caatcaggct gtttaagctt 3085741 cctttgtatt tacggagcgg cgtctcctga atggcattct ccaaatgctt gctgaggata 3085801 tccatcgaaa tgtcctgtcc gctgatcatg acatttggtc tgccgtccgg ctcagcctcc 3085861 tgcacctgtt tcggcgcttc ttttgcagcg atgggctgag acattctcat attcgtttta 3085921 tattgcttta aatcttcttc atccacacgc atctgccttc cgacacggta agcaggcagc 3085981 acgccttttt taatcaagtc ataaacggtc agctttgata ccttcagcag acctgcaact 3086041 tcttctatcg tataggaaga ggtttcattc atcatcatca ctctcctatt ttattatacc 3086101 ttttcgccga atgtaaaaaa acccacataa accaaacata atcagttata attagttata 3086161 tctaatgata aggggtgcaa tcatgtttaa gaagtattct attttcatcg cagccttaac 3086221 tgcttttctg cttgtagcag gctgttcttc aaaccagtct tcaacggaca gcgagaaaaa 3086281 agtaacgtta accatctcag ctgccgccag cgcgcaggat gcacttgagg aaatccaaaa 3086341 aaattatgaa aaagatcatc aacatataac catccaagat aactatggct catccggcgc 3086401 cttgcaaaaa cagatttctc aaggagcagg agcagatctg ttcttctcag ctgctgagga 3086461 taaatttaaa aagctggtgg atgatggaga tatcgcaaaa aaagacagca ctgaattagt 3086521 cggtaatgaa attgtgctgg tcgtaccgaa aaacggagat tcacctgtga caagcttcag 3086581 caatctggct gaatcagaaa aaatcgctct tggcactccg gaatccgtac cggcaggagc 3086641 ttatgggaaa gaatcactga caaagctgtc tttatgggac aaagtgaagg ataaaattgt 3086701 gtatggaaaa gacgttcgcc aagttctttc ttatgttgaa accggcaatg tagacgcagg 3086761 tgttgtttat aaaacagatg ccctagtctc gaaaaaggtc aacattgttg acgaggcaaa 3086821 agcagataca cacagcccaa ttgtctatcc gttaggaatc gtaaaagata caaaacaccg 3086881 taaggaagcg aaggaatttt acgaatacct gcaatctgat gaagcaatga aagtatttga 3086941 gaaatatggc tttactgccg agtagcataa gcgcttcaga atttttcaca cccgttgtgc 3087001 tttcctttca ggtggcggca gttgccggaa ttgttgtcat tattctcgga acacttgctg 3087061 gagcatggat gtcacgggca tcatttttcg gaaaaacggc actcgaaaca tgttttatgc 3087121 ttccgctcgt tcttccgcct actgttgtcg gttttattct gatcgtcatt ttcggaaagc 3087181 acagcttcat cggacaagcc atcgagtgga ttttccagca gcctgtcatt ttcacctggt 3087241 gggccgctgt gatcgcctcg gctgttgtag cctttccgct tatgtatcaa tcagccaaaa 3087301 ccggatttgc tgacattgat cccgatatac aaggtgcggc aatggtagac ggcgctagca 3087361 gatggaaagt gtttatccat atctccgtcc cgcttgccta tccttcgtta ctgaccggaa 3087421 gcatccttag ccttgcgcgg gcgctcggag aatttggcgc aacactcatg tttgcaggaa 3087481 acatccccgg tgttacgcaa acactgccga cggcgatata tgtcgcattg gattccggca 3087541 acaataccct tgcttgggcg tgggtcgtct gtattgttgt catttccttt ttgatgctgt 3087601 ttttcattca acagaaaaaa acgcactaaa aaaactcccc ataacgggga gttttttgat 3087661 taaaacagaa gctcatcagg atttggaccg acacgctcat ctttatttaa tgcgtcaatt 3087721 ttgtccatgt cttcttgaga caattcgaaa tcaaaaatat cagcgttttc gatgatacgg 3087781 tgttctttaa tggattttgg aatggttaca actccatgct gcagatccca gcgcaaaatc 3087841 acttgagcca cagatttatt gtgtttttca gcaatctgtg tcagtacttc gttatccaaa 3087901 agctgtccct gcatgagcgg agaccacgct tccagctgaa tgccttgccc tttgcagtaa 3087961 tctcttaatt ctttttgcgt caagcgaggg tgaaattcaa cttggttcac catcggtttg 3088021 atttcagcat ctttcaacag ctcttctaaa tgatgaactt ggaaattgct gacgccgatc 3088081 gcgcgaattt tgccgtcttt gtacagcttt tcaagcgcgc gccatgtatc tttatattta 3088141 tctttgccag gccaatggat caaatataaa tctaagtaat caagctgcag tctttctagg 3088201 cttttttcaa aggcagcaag cgttgtttca tagccttgat cttcattcca cacttttgat 3088261 gtgatgaaga gctcttctct tgccacaccg gattctttaa tcccgatgcc aacgccttct 3088321 tcatttttgt agatcgctgc tgtatcaata ctgcgatagc catttttaat tgccgctttc 3088381 actgattcag tcgcttcatt accattttct actttaaaaa cgcccagacc gaaccaaggc 3088441 atttcaactc cgttatgtaa ctttacagta tcttttaaac ttgttggcac ttgaacctcc 3088501 accctttcac tgaaatgtaa gcgtctatat tatctcacat tcctctcagc cgataccaat 3088561 aatacgctta agaccctctt tttgcttctt ttttcacagc acaggcaaat ccaaacacta 3088621 tttttttcct attttaacaa tattgagatt acaaatacat tgagcagggt atgcgtgtag 3088681 tgtaaccaaa tgaaaacaaa ggaggaaaca acttgaaacg tattcgtatc ccaatgacac 3088741 ttgctcttgg tgccgctttg acaattgccc ctttgtcctt tgcttccgct gaagaaaatc 3088801 ctgctccgaa gatgtcgcag acaactactg ctggaacaac tgccgctgat gtaggtttaa 3088861 acgtcaacct ggatgtactt ggaattgcca accagatcgc tgatgccatc aaatccgcac 3088921 agaataggga tggctttgtg aaaaacctca tggagtcttc cttctacgcg tccggccaaa 3088981 aatataacgt catggtcttt aatttaagcc aggaatatga agatcatttg aacggtgtgc 3089041 aattttacgg ctcagccgtt tacgacggca ttacgtatgg catttgggta tttgaagatg 3089101 gaacctttac aaacaaaggc gatggcggct ggatcaactg ggccttcaga ggctggttcg 3089161 accgggatgg cagcactgtc gcatttcatc gcccttaata taaaaaaagc tggcgctcta 3089221 acgccagctt tttttctgca tttattcgcc gccttcaagc atggcggctt cgacatcatt 3089281 aatgtattgg cgaagctcat gggagatgtc ccgggaaatt tccctctctt cgaagagcgt 3089341 ttgaatttca tttctgatcg cctgcacagc cttcagcttc acttccagct tctgattttc 3089401 aaaatgggca cttgatttta actcatgatg gctgtgctcc agcctgaaaa ttaactgctt 3089461 atagaatgta atgacagata aaaacacttc tttatgctca tccgtcttat gtttttccag 3089521 atattctatc gctgcttttg ccgttttcac tcttgttgcc cgtatcaatc ccgcttcatt 3089581 taaaatcgac atctccggct ttttatgttc accgaagaaa atccaataca tcagcctctt 3089641 gagccttgtt tttgataacc cgactttaaa cgggttggca tacaaaattt ccaactcgtt 3089701 aaatcgttct tgcagcacat ttgctgtttc ttccgggatg tctccccgct ccagcatttt 3089761 catcagcgcc tcttgctcag ccttaacccc ctgcgcacgg acttttcgct cgtgcttctt 3089821 aatgcgatta gatgatgtat actgctgaaa acgaagattt ttcattttct cattgtattc 3089881 agctatcacc gcaagagagg ccgttttgtt tgtctcattc atgtcctctt taatcgtttg 3089941 aagggctgtt ttgatcaact tgcgtctcgc cgtcagcagc ttcttatttc gttcctcgtc 3090001 ctcttcttct ttttcagtca gaattggcag cacaacggtg gcaatgacaa gcgtgcataa 3090061 aatgacgccg gctgctaaaa agagaatcag atttctttcc ggaaacggcg taccgtcctc 3090121 caggaaatac ggaatggaaa aagaacctgc aagcgttact gctccacgca caccggaaat 3090181 cgaaattaac agcgtcgaac gaagacccgg tttatagatg ttctgatctt tattaaagaa 3090241 ccatttgccg ttccagaaga acagcaccca caggaatcta aggagcatta atgtaaatgt 3090301 gatgactagg atatagccga tcaccttcat gttgctgatg gcagtgtcgt taaagataac 3090361 agaaataaca tcagggattt gcgtgccgag aataacgaag accaggccgt tcaaaataaa 3090421 taaaataatg ttccacgtac ttgaggagac gatttgcagc ttgatcatcg ttgattccag 3090481 acgatcctgt tcaaccgcat gggtaatacc gccagctaca acagctaaaa tgcccgaaac 3090541 gccgatttct tcagctgcca aataaatcac aaacggcgtc agaatttgaa tcagcatatg 3090601 catcgtgaca tcctgcatgc caaggcggcg cagaaatagg cgaaaacgaa taatcaaaaa 3090661 tgaaatgaca accccgcaca gcaagcctcc gagagaaata aagacaaagc tgacagccgc 3090721 ttgtgctaat gaaaatgcac cagtcactgc cgctgcaatc gcaaacttaa aggccaccag 3090781 acctgatgca tcattcatca gcccctcacc ttccagcagg cgaagaatcc cttttggcat 3090841 tttcactctt cctgataatg cgctgacagc gacgacatca gtcggtgaaa gaatggccgc 3090901 aagtccaaag gccgctgcca gcggaatagc aggaatcatc cagtgaatcg tgtagccgcc 3090961 tacaatcaca gtcgcaaata caaggccgag tgcaagcaat aaaatcggag cccttaaatt 3091021 ccaaagctct gcccgcggtg tcctctttcc atcattaaat agcagaggcg cgataaaaag 3091081 aacaaaaaac aattcggtgt ttaattcaaa atgaagtccc tgtggaaatg aggcggcaag 3091141 aatcccaaga gccacttgaa tcagcggcac cggaataaac ggaataaacc ggttcacgat 3091201 attagaaatc gcaataatcg ttaataatac gagcacaact aaaaatatgt ccaaatgcat 3091261 gacctccttc gtctgttgtg tgtcggcatg atgagccaaa aaatctgttt gtctaaaagc 3091321 ccttgagcta gggtggcctt gcatccgcta tgtggtttcg caggagttct ctccacactt 3091381 gtcttctttt atagtaccct ttttagggta ttttttctca tgatatgctc acagtgaact 3091441 tttttgcaga agagcaaatt atagaaaaaa gagacaggaa gctactccct gtctctcgtc 3091501 tttctttctc aatcatgaaa attcgtaccg tcagttgttg ctttaataat gcccgcgcga 3091561 atgacaaagt caccgaaatg ctcgccttcc tcgcgttctt tcgcatagcg ggaaagaagg 3091621 atgcgcagct cgcttaaaat gtctgcttca ccgatgtttt cacggtacat tttgcttaaa 3091681 cggcttccgt caaacgcagc gccaagatac atattatatt tgcccggcgc ctttccgata 3091741 aatccgatct caccgagtgc atgacgtgca cagccgttcg ggcatcctgt catgcgaatg 3091801 gtgatttcct gatcacgaag gccgttttcg tcaataatct cttcaatctt atctaacagg 3091861 gtcggcaaat aacgttctgc ttcagccatt gccaatccgc aggtcggaag agcgacgcac 3091921 gccatcgagc tgcggcgaag cgctgaatag tgcttgccgt cagttagtcc gtactgttca 3091981 attaaagcac tgatttcttc ttttttatcg cttgaaacgt tcgcaatcat taagttctga 3092041 ttggctgtca gccggaactc acctgtatga actttggcga tttcccgcaa gccagtcatc 3092101 agcttataat catcgtaatc cgttatacgg ccgccttcga caaacagcgt gaaatgccat 3092161 ttatcctcga tgccttccac ccagccatag cggtcgccgt tatgatcgaa atgatacggc 3092221 ttcgcttctt ccaggctcca gccgagacgg ttttccaatt cttcttttac gttttctaaa 3092281 ccgaggcggt caactgtgta tttgaaccgc gcatttttac ggacagaacg gttgccgtaa 3092341 tcacgctgaa tcgtaatcgt tttttcagca acgtcataca tttgctcagg ccggcagaaa 3092401 ccgatcacct tggctaattg cggatatgtc gcagtatcgc catgcgtcat tcccataccg 3092461 ccgccgattg ccacgttaaa accgatcagc ttgccatcct cgacaatcgc aatgaatccg 3092521 agatcttgtg aaaagacgtc aatatcatta gacggcggaa cggcaatacc gattttaaac 3092581 ttccgcggca gatagagcgg tccgtacatt ggctcgactt cttcctccgg cgtgccggca 3092641 actctttcct catcaagcca aatttcatga tatgctctcg tccgcggcag cagatcatca 3092701 cttaattttt tagaccactc gtatacctct gagtggattt cagattgata agggtttgat 3092761 gcacacatga cgttacggtt tacgtctccg caggctgcga tcgtatccaa aagtgctgag 3092821 tggatcgtct gaatggtttt cttcatgttc catttcagaa ttccgtgcat ttggaatgtt 3092881 tcacgtgtcg tcaattttaa tgtgccgttc ccgtatttct gggacaggtc atccatgaca 3092941 agccattgtt caggcgtcga gacgccccct ggcatacgca cgcgcagcat gaactgatat 3093001 gcgggctcaa gcttctgctt ttggcgttca tttcggaggt cgcggtcatc ctgcaaataa 3093061 ctgccgtggt gtttcatcag gcggttatca tcatccggaa ttcccgcact gattcgatcg 3093121 agcatcactt ctttcagcgt gccgcgcaaa taatcacttt cttttttaat gcgttcaaca 3093181 tcacttggag agccgtccgg tgcttttaga attttggtca ccatgttgaa aaactccttt 3093241 caagtcaaat caatatacat cacgctgata gcgtttttgc tgctgcatat cggcaagata 3093301 agcctccgcc tcttcgcggc tcatattgcc ttctttttcg ataatttcaa gcaatgtgtt 3093361 atggacgtca tgcgccatgt gcttttcatc tccgcaaatg taaacagccg ctccttcttg 3093421 aagccattca aacaattctg cgctatgttc aagcatgcgg tgctgcacat atactttttc 3093481 ttccgtatca cgtgagaacg ccacatccat ttttgtcagc acaccgtctt tgagccaatt 3093541 ctgccactct gtctggtaaa ggaaatccgt gacaaagtgc tgatcgccaa agaacatcca 3093601 tgcctttcct tccgctcccg tctcctcacg ctcctgcata aacgaacgga aaggtgcgac 3093661 gcctgtccca gggcccacca tgataatcgg tgtttcaggg tctttcggaa gcttaaagtt 3093721 ttgattgtgc tgtacataaa ccggcagtgt gtctcccggc tgcagtcgtt ccgcgcacaa 3093781 aatcgagcag acgccttttc gttcacggcc gtgcgcatcg tagcggactg cgccgattgt 3093841 taagtgcact tcatccggat ttgcggataa actgcttgca atcgaataaa ggcgggcagg 3093901 catttttcgc aaaatcgaga caaactcctg cgcagataca ctaaatgggc catagtcacg 3093961 gacgagatca agcaaatcgc gcccttcaat ataggctttt acattctcct catttcccgg 3094021 ggctaaaagc tctctaagct catcgttccc tgtcagctgg gctgcctgtt caagaagcgg 3094081 ttttgtgaga acggtaatct catagtgaga aatcagcgct tctttcagcg gtcggacatc 3094141 accttgctta ttaagcgtca caatttcttc cgggtcccaa ttcatttcct taaggagcag 3094201 ctcgacaagt tccggatcgt tttccggata gacgccgagg ctgtcaccag gctcgtaagt 3094261 caggccagat ccttcaagag acagctccac atggcgtgtt tctttatttg atcctctgcc 3094321 gtttaaattt aaattttcta acacttcagc ccgaaacggg tttgttctgg aatacgaaga 3094381 ctcaccggtt tgtgacgcag ccgccggcgc aggcgcggcg cttccgcccc cagcttcatt 3094441 taatcctttc aatacaccct caagccattc ggctgccggt tcatcatagt caagatcgca 3094501 atcaacgcgc ggagaaatcc gttttccgcc gagttcttct aagcgttgat caaattcttt 3094561 ccctgtctgg cagaaaaatt cgtacgaact gtcaccaagc gccaaaacgg aaaagcgcag 3094621 gtcttcaagc ttaggcgccc gtcttccgtg cagaaattca tgaaacgaca gcgcgttatc 3094681 aggcggctcg ccttctccat gcgtactgac gacgattaaa agattggtta ccttcttcag 3094741 ctgattcggc ttaaaatcgc tcatggatga gacggtcact tgaaaaccgc tctgttcaag 3094801 ctgcttgccg gcattttctg caagcccctg tgcgtttccc gtctgtgaac cataaagaac 3094861 ggtcacttct tttgaaacgg ccggtgccgg tgcttccgct gacacagctg ccgccggcgt 3094921 acccgcagct tcttgggcgg aaacagattg agcggataaa tatccgctca gccagatttt 3094981 ctgggattcg gtcaaggtcg gcagaaggcg gttaaggagc tctgcctgct cctgattaaa 3095041 cggactgttc attacctgaa gttgcaacgt atccacctca caaagttata aactgatcga 3095101 aaattgcatc taattgaact ttaccggaat actaggctta agtaaaatat atttacatga 3095161 tgataactat taagaatcct aatgataaaa cggctatgct tcatgtaaat agaaaaaaga 3095221 gaaggactcc cttctcttca ttcagcaatc tgatataagt gaggcggcac agcggttaca 3095281 aacggactgg cttcacctgt ataaaatacc gccagcatgt gcatcgcacg ggtgcacgca 3095341 gtatataaaa gcctgcggtc gtgctctgta tgatagtgtt cttcagatgc atcatagaca 3095401 agcactgcgt caaattcaat tcccttcgct aaatacaccg gaatcacgca aacacccttt 3095461 tgaaatggtt gattttcttt atgaatcagg cgaacatctg tatattcact catgtgggcg 3095521 tgcgcctgta tgcattgatg cgcagtcttg cagatgacgg ctattgtttc gtgccctttt 3095581 ttcttgagcc ggccaatttc ttgcgcgagc ttttggcaaa ggctctcatg tccttcagtt 3095641 ttgacaacga gcggcatttc cccgcttcta ttaaacggct caatatccgc tccatcttga 3095701 agcatcgctt tggtaaactc gacaatctgc cttgttgatc tgtatgttct ctttaaacga 3095761 acatactcag caggctcatc ctcaaagcac gcatccatac gctgatcccc gtttatggta 3095821 tgcgcgtaga tggactgatt gatatcaccg agcactgtca tgctggcagc cggaaaaatg 3095881 cttctcatgt aagccatctg aaacggtgaa tagtcctggg cttcgtcaat aaatagatgt 3095941 ttgattttcg tatttttctt tctgccctca atcagatcct gcatataaag aaacggtgcc 3096001 gcgtcctcat agagcaattt attatccgta aatgccgaac gggtcagctc acctatcgca 3096061 tccatcttct catgttgaaa ttttcctccc cagccagaaa acaattgcaa ataaagttgt 3096121 gtaacatcaa gaaatgcaag gagcctgact gcctgtttga gcggtttgaa agcttttttc 3096181 acaatgatgg cggcaagcag ctgctgctct ctttgataat cgttaaacgt actctcgctg 3096241 aaccgtttcc tttcctgcag ttttttgtac acgtccaagt agtcctcttt gtcaagcagc 3096301 tcagcttcat gaacaaccca atcctttcgc cgttcctttt tctcaagctt gttaagctca 3096361 ctcagcagcc acttcgcggt ttgctccatc cgattcggaa tggagtgatt ttgatccaat 3096421 gagtaaaaat aggattgaat ttgctccttt gtgatcagct tttgtccgcg gaatataata 3096481 tttttaaaaa tcatcccttc agaggaaagc cgtgtgacgt attcattaat gaattgctga 3096541 aaggataaac ccgccttcca tgtgattcct gcaagccttg ttggaaaatc gcctcccttt 3096601 gtttcggtca ggcaatattc gagctgatca aaggggcttt cacatttgaa cttgcggcca 3096661 agacgatgct cgatatattc ctgaaacgtc gcctgctcca tattctcttc tcctaactcc 3096721 ggcaaaacag aggagacata gctgttaaat aagaagttgg gtgaaaacaa aacgatttgt 3096781 ccggcatcaa tgacaccgcg gtgcctgtat aacaaataag cgacacgctg aagcgcagcc 3096841 gatgttttcc cgctgccagc cgctccctgc acgatcagga tcttgctttt ttcattacgg 3096901 ataatctgat tttgttcttt ctgaatcgta gacacgatgt ttttcatttg ggtatcagag 3096961 tgatggctta atacctcttg cagcatttca tcgccaatcg tcatatcggt attaaacatc 3097021 gccttgagag tgccgttttt gatcataaac tggcgtttca gcaccatttc cccttctatc 3097081 gtttcaccgg gcacctcgta ctccgctttt cctggggaat aattgtagta caaacttgat 3097141 atcggcgccc tccagtcata gatcagaaag tgttcctcct tctcatccaa acaggaagct 3097201 aaaccgatat aaattcgctc tgcctgctcc tcgccgtttt caataaaatc aatccggccg 3097261 aaataaggcg attttttcaa ttgatgaatt cgtttgagct gctgatccat gcgccgatga 3097321 ttgtgttccc gatcagacag cagctctgcc tgctgcttaa tgctagccat cgtttcaatc 3097381 gcttcatggg catcatcaaa attaacctta acatcctccc aaaagctttt tcttaatccg 3097441 atgatatcat gcttcaaccc gcccgcagac gtttccagaa accgctcttt tttttcgagc 3097501 tccttcagca cctcatctat tctcgactgc tcttccttcc attccttatc ctgctgattc 3097561 atgaacggca cctccagaaa atagttgaca aacatagatg aaatactgta aaatataatt 3097621 ggatacatat attaaatata tgatgcaaac tggcaaatac aatttataat agcacattca 3097681 cccaatacca atcaaggttt gggttattta tattatgcag aaaaaaaccg atttcacttc 3097741 gaaatcggtt tttttgctat taattatcta agcgaaaaga acggtttggc agcttccaat 3097801 taaacatata ggaacaaacc cggcaaacaa cgagcacgaa aaacagaacg tataagccga 3097861 acgagttccc cagccagccc aagccgacga ttaaaccgcc gagcgccgcc cataccgcat 3097921 agatttccgc tttcagcaca agcggtttgc gcccggcaag aaggtcgcgg atgatcccgc 3097981 ccccgcttcc cgtcagcacc gcagccacga tcacggcact aagcggatgg cccattttga 3098041 cggcatacag tgcgccttgg atagcaaagg cagcgaggcc gatcgcatct gataaattgc 3098101 cccacttatt ccaatgcttc agcagcagct tcggaaacag aaacacaatt gtaatagata 3098161 aaagcgcgat ttgaaagtac gctccctgct cccatagcgc tgacaccgga acaccgatca 3098221 gcaaattgcg gatcgctcct cctccaaaag ctgtgacaat ccctaatata taaactccta 3098281 aaatatcata ttcctcttcc atcgcaacaa ttgcgccgct gactgcaaac gcaatgatgc 3098341 caatcacact aagcagctcc caagccattc tgatgactcc cttttatgtt tgttaaattt 3098401 tctgacgacc tctagatttt ataatcgctc cagcgtaaaa tcaataacat tttcatgaga 3098461 aaaaaagata aatttagagg gaatacggct attgctgatg gacatgagtt tgcgaaatta 3098521 aaaaagcgcc cggcatacgc gggcgctttt tttgttattc agatttttcg cctttcagca 3098581 ggcacataaa aatgataatc aggataaaag caatcagggc caggaatgga atcgtaataa 3098641 aaccaaacca gttaatatat tggcccgagc acggcacgcc gctgacacat ggcttaatgc 3098701 cgctaaagcc gggcactttt tgctctaagt aatgcatgat cgaaatgaat gccccaataa 3098761 tcgccatcgg gagcacatat tttttcactc gtgtgtcccc ttgaaaggtg gcgatgccta 3098821 aaatcaggac gagcggatac atgaggatac gctggtacca gcacagttca catggaataa 3098881 actttctgat ttcactgaaa tacaggctgc ccagcatagc gataagagcc acaacccagg 3098941 aagcatataa aaatacgatt ctatttttca tattgttact tccctttcag ctctttttct 3099001 attgtctctt tgatttcatc ataatccgca aaatttttga tcactttatc attgacgtaa 3099061 atcgtcggtg ttgcctgtat gttcattttt tgattaaggt cagaatcctt ttccacttga 3099121 gaagcgaatg tttccttatc aagattttcc ttgagcgtct caggttttat ctttgtggtg 3099181 ctttttgcaa gatcaccaag gaggcctggg gttacccatt cctgttccgt atccggctgt 3099241 ttttcgaaca gcttttcatg gaaatcccag aaagagtcag ggtcttcctt ccatacttct 3099301 tcagatgcaa gagccgctaa ccttgaacct tttccatgga acatgacgtt cacgaaagaa 3099361 aatttcacat cgcccttatc aataaagtct ttttgtattt ttggaaagat gtcactgtta 3099421 aacaccttgc aagacggaca tttgtaatct ccgaattcta ctacagttac cggtgcatcg 3099481 tccttgccaa gcacaggctg ccctttgata gacggctgtc cggacaccgc atcattgcct 3099541 tgttccgttt tgttattaat gatgacaatg gctgctagca atacaacaac cacaaccgta 3099601 aggatgaccg cgaatttcgc agaagactgc tgtttctttt tcactccgac acctcatcgt 3099661 tttaaaatta aaaaagaagc ggatcgcaat tgacccactt ctttatttta acaagacaag 3099721 cgctgataag aaaaccccga aaaaatgaat tctctccgac aatttatttg tttttgagac 3099781 gcatgacgcg catggcgttc gccacagcaa gcagtgtaac gccgacatct gagaaaaccg 3099841 cttcccacat ggtcgcaatt ccaaatgcac caagaatgag aaagatcgct ttcacaccta 3099901 aagcaaagcc gatgttttgc cacacgattc gccgtgtccg tttcgcaatc cgaatcgctt 3099961 ctgctatttt tgacggctga tctgtcatca gcacgatgtc tgcggcttct accgcggcgt 3100021 ctgagccaag gcctcccatc gcaaccccta tatctgcgcg tgcaagcacc ggcgtatcat 3100081 tgatgccgtc accgacaaaa atgagttttt cactaggcaa aagcttagct tctaatgctt 3100141 cgacctgcgc gactttatct tgcggcagca gctctgcata tacctcacca atcccaagct 3100201 gttttccgac ggcttctccc gtttgtttcg aatcacccgt cagcatagct gtctgtttga 3100261 tcccaagcga cttcagatca gcaaccgcct gtgctgcgtc ttcctttatc tcatccgcta 3100321 tgatgattgc tccggcatag cgttgatcta cagcaacgtg tacgattgtt ccagcatttt 3100381 catccgggac atcctcaatt tgttctcttt ccatgagctt tttattccca gcaaggatct 3100441 cagttccatt tacctttgca aaaatgccgt gaccggagat ttcttcgtat gactcaatct 3100501 catcggagga aagcattttc ccgtaagctt tacgcacaga ttcagcaatc ggatgctgtg 3100561 aatgaagctc agcgtatgcc gccgcttcaa gtaatctatc ctttgtaaaa ccttccgcgg 3100621 gtttgatttc tgtcacttca aagctgcctt ttgttagtgt tcccgtttta tcaaacaccg 3100681 cgtatttgac ttgattcaaa gcttctaaat aattgcttcc ctttacaagc actccggcct 3100741 ttgaggccgc tccgattcca ccgaagaaac cgagcggaat agagacaaca agcgcacaag 3100801 gacaagaaat cactaaaaag ataagcgcgc ggtacaccca atcggaaagc gcggcgccag 3100861 aaagaacaag cggcggaaca aaggccagca ataccgcaat gatcaccaca gcaggtgtat 3100921 aatacttggc aaacttcgtg ataaagtttt ctgtccgggc tttacggctg ctcgcattct 3100981 gaaccaagtc taatattttt gatactgctg attcctgata gccctttgtg acttcaatat 3101041 gcagaacgcc gttttgattg ataaagcctg acattacatc ttgtccttcc gcagcttttc 3101101 tcggaacgga ctcacctgtt aaagcagatg tatcaaccat cgctgaccct tgcacgacct 3101161 taccgtccag gggtatgctt tctcccggat taaccacaat gatgtctcct gtctgaacgt 3101221 cctccgacga aacctgttcg atgccgttct ttgttttgag attggcgtaa tcaggccgta 3101281 tgtccattaa cgcactaatt gattttctgg aacggctgac cgcggctcct tgaaaaagct 3101341 caccgatttg ataaaacagc ataacggcga ccccctcagg gtattgctga atcagaaaag 3101401 cgccgattgt ggcaagagcc attaagaaat gctcatcaaa cacctgaccg cggatgatgt 3101461 ttttgactgc gcggattata atgtcaccgc cgataatcaa ataagcaccg aggaaaagga 3101521 aaaattcaat ggttcccgac tgaaccaaat atgccgctgc gccgagaatg acagccgccg 3101581 ccattctgat cagcatattg accattcgat tacgatagcc atcatcagct gatttcttta 3101641 tatgcttttg gcgaaccgtt acatgcggat caattgattt cacttttttc tctactttat 3101701 tcgtgaccca ttgctcttct ttcccatcgg ctgagacagt taaggtgctt gccgcaaaat 3101761 ttaccgcgca tccgttaatg ccttttatgc ctttgactcc attttcgatt tttcgggcac 3101821 aattgctgca atccaaaccg tccagaacat attcctgttt cactagtctc accttacctt 3101881 ccgatttagg gttccctctt caaagcgtat caatgagtat tgtatttatt ttatatatat 3101941 gagcatatac tcatatataa gttacaccta ttatatgttg ttttccaaga aagtgtcaat 3102001 gaaaaacaaa aaccggcata tagccggttt ttcattttac tttttgcaga cgaagagcat 3102061 tcagaacaac ggaaacggag ctgaatgcca ttgctgctcc tgctatccac ggtgctaaaa 3102121 atccaagtgc tgcgattggg atgccgaggc tgttatagcc aagcgcccag aataagtttt 3102181 gtttaatgtt tttcattgtc aatctgctca tgcggattgc gtcggcaatg ctgttcagat 3102241 cgccgcgaat aagtgtaatg tctgctgttt ccatggcaat gtccgtgcca gttccaatcg 3102301 ccatgccgat gtcagctgtg gcaagcgccg gcgcatcgtt aattccgtcg cctaccattg 3102361 ctgtctggcg gccttctttt tgcaagcggg cgatttccgc cgccttttgt tcaggaagaa 3102421 cttccgcaat gatattcgca attcccgctt ccttcgcgat ggcttctgcg gttctgcgat 3102481 tgtctcctgt catcatgatg acatcaagac ccaactcttt cagacgggca acagccttcc 3102541 gcgacgtatc cttaatcgta tctgcaactg ctactagccc cgctgcttct ccatcaatgg 3102601 atacaagcat aactgttttc ccttcggcct ctagctcttc catttgggcg agaagagccc 3102661 catgctcaac ctgttcgctc tccattaatt ttcttgtgcc gacgagaatg ctttttcctc 3102721 cggcttcagc caaaatgcct gcgccgactt ttgcttcaaa gcgggtaagt ttcggtatct 3102781 caagcccttt atctttcacg ccagcaataa tcgcttcgcc aagcggatgc tctgatcccg 3102841 tttccgctgc cgctgcaaat tgaagcaaat ctttttcttc aaaacggccg aatggaatgg 3102901 catccgtcag acgcggcttc ccgtttgtca cggttccggt tttatcaaga acaattgtat 3102961 cgagacgatg tgttttttct aaatgctcgc cgcctttaaa taaaatcccg aattcagcag 3103021 cgcgtccaga tccagccatt atgctcgtcg gagtggcaag accgagggcg caaggacagg 3103081 caatgacaag aaccgcaatg aacttgctga tcgcttcggc aaaatcgcca ggagccgccc 3103141 aaagatacca aatgagaaaa gtgagaaccg caatccccaa tacaatgggt acaaaaatgc 3103201 ctgaaatctg gtcagcgaga cgctggatcg gcgcttttga cccttgtgct tcctcaacaa 3103261 ttttgatgat atgagaaagc gcagtatcct ttccgacgtt gacagcttta attttcagaa 3103321 agccgtttgc gttaacggtt gaacctgtca cgctgtcacc aggatttttg tcaacaggaa 3103381 gactttctcc tgtaatcatc gattcgtcaa ccgctgaacg gccttcaacc acttctccgt 3103441 cgacaggaat tcgttcgcca ggtttgacgt aaacaatgtc attaacaagc acttcgtcga 3103501 tcgggatgat ttgctcctgt ccgtctctta caacagtagc tgttttcgct tgaagcttca 3103561 tcagcttttt aatcgcatcc gaggaacggc cttttgcttt tgtttcaaac aacttgccta 3103621 ataaaatcag cgtcagcaaa atcgcgcttg tttcataata aaggccgtct gtatgcccgt 3103681 gagagccaat gctttgaaaa gttagataaa gactataagc gtaagcagcc gtcgtaccga 3103741 gggcgaccaa tacatccata ttggcgcttt tatttctaag cgccttatac gcacccacat 3103801 aaaacggcca gccgatcaga aactggactg gtgtcgccag cgcaaactgc atccacggat 3103861 tgagaaatat atccggtacc caaatgaatg atgtaaatgt aaaatggctc accatcgccc 3103921 aaagcaatgg aaatgacagg acagctgaaa aaatcagtct cgccgtttgc ttccgttctt 3103981 ctttcttttt agcagcagcc tcactgtcct gttcaccctt caactttagc ttatatccaa 3104041 gcttatctac cgcttctttc aaatcgctga cagacgcttc ttttggattg tattcgaccg 3104101 taactgtttc taaagcgaag tttactggtg catttgcgac gccttctatt ttgttaagcc 3104161 gtttttcaat ccgattggcg caagccgcac aggtcatgcc ctcaatatcg aattcagctt 3104221 tttctgtaac gacgtgatag cccagcttct ctattttttc ctgaatcgct gcagtccctg 3104281 tttcagcagg atcgtagatt acatttgatg tttccgttgc cagattaaca tttgcatccg 3104341 tgacaccggg catccgcttc aggccttttt caattctggc agcacatgcc gcacaggtca 3104401 taccagagac ctgcatcgcg atttcctttt gttcactcaa catactcact cctttatata 3104461 cacctggggg gtatataaaa atgaaagaaa tatcgcgcct ccctaaaggc gcgatacctt 3104521 gaatcacttg gctacgtcat agccctgatc ttctatcgca tccgcaatat ctttgactga 3104581 tactttgtca gcatcaaacg aaacatcgac tttacccgct tccagattga catgaacggc 3104641 actgacgccg tccagttctc ctacgcttgt ttctactgct ttgacgcagt gctgacaaga 3104701 cattccttca acttgcaatg ttttttgttc catatcaatt cctcctgttt attctttcta 3104761 ttttcatcct accatacccc cgtagggtat tacaataaaa aacgctttat gattttgtga 3104821 actttttaaa tacgtccaaa agctcagaaa tggcctgttc cccgtctccg cttttgatgg 3104881 catctgctac acaatgatgg gcatgatcct caagcaaatg aagcgccaca tttttcattg 3104941 ccgcctgaac agctgaaatt tgcacaagaa tatctacaca atatctgtcg ttttccacca 3105001 tgttttgaat gcctctgacc tggccctcaa tccgcttaag ccggtttgta atctgatcct 3105061 tttctttcga gcttttatgg tttaatgttt tatgttcgtt atgcttttcc atgcgtacac 3105121 ctctgtttaa tgatattaat tcccattata ctgattgtcc aaacggttgt ctaagcatgc 3105181 cgacgcaaaa aatgaatcag ttaggtttta ccatttgatc aggagggtat atacttctgt 3105241 tgataacgct tttaaagggg agaagaaaag tggatacgat caaggttgga atattaggat 3105301 acggattgtc cggttctgtt tttcacgggc cgctgctgga tgttctggat gaatatcaaa 3105361 tcagcaaaat catgacatca cggacagaag aagtgaaacg ggattttcca gatgctgagg 3105421 ttgtacatga gcttgaagaa atcacaaatg accctgccat tgagcttgtc attgtcacca 3105481 ccccgagcgg ccttcattac gagcatacta tggcatgcat acaggccgga aaacatgttg 3105541 tgatggaaaa accaatgaca gcaacggccg aagaggggga aacattaaaa agggctgccg 3105601 atgaaaaagg cgtattatta agcgtatatc ataaccgacg ctgggataac gattttttaa 3105661 cgattaaaaa gctgatctct gagggatccc ttgaagatat caatacatat caagtttcct 3105721 ataaccgcta cagacctgaa gttcaagcgc ggtggcggga aaaagaaggc actgccactg 3105781 gtacgctgta tgatctcggc tcccacatca tagaccaaac cctgcatttg tttgggatgc 3105841 ctaaagccgt gactgcaaac gtgatggccc agcgggaaaa tgccgaaacg gttgactatt 3105901 ttcatttaac cctggattat ggcaagcttc aagccattct atacggagga tcaatcgttc 3105961 cggcaaacgg acctcgttat caaatccatg gaaaagattc tagctttatc aaatatggaa 3106021 ttgacggaca ggaagacgca ctcagagcgg gaagaaaacc agaggatgac agctggggtg 3106081 cggatgttcc ggagttttac ggaaagctta caaccattcg tggctccgac aaaaaaacag 3106141 aaacgattcc atcagtaaat ggctcctacc ttacttatta ccgtaaaata gcggaaagca 3106201 tacgagaagg tgctgcgctg ccagtcactg ctgaggaagg tattaatgtc atccgcatca 3106261 ttgaagccgc gatggaaagc agtaaagaga aacgaaccat tatgctggag cactaaaaca 3106321 aaagcctccc caaataaggg gaggcttttt cattagaatg tttttcctgc ttctttcgca 3106381 cgcgcaatcg cgtcttcttt gatttgctgt gctttatcag gctccgcatt atgtccctct 3106441 acgaaaatgc catcgaatga tggtacgccg aagaagttca tcatgatgcc gatgtagcgg 3106501 tgccccattt ccatctcagc cgcagggcct tctgaatagt agccgccgcg cgcttggata 3106561 tgaattgctt ttttatcagt taacaagccg acaggacctt gttctgtgta tttgaatgat 3106621 tttcctgcaa cagcaacaga atcgagatac gctttcatca ctggcgggaa tgagaagttc 3106681 cataaaggag taacaaatac gtacttatca gctgatgcaa attgatcgct aagctctccc 3106741 aaacggccta ctttcgcttt ttcgctttca gaaagctctt caaagcctgt acctgactga 3106801 agctttcccc atccgctaaa tacatctgcg tcaatgtgcg gaatgttttc tttgtacaaa 3106861 tcgatatgta caacttcatc atttggattc gcttctttgt aagattcgat aaatgcttta 3106921 cctgttgcca tactgtacga agttgcttcg tcatgtggat gagcagtgat atataatact 3106981 tttgccattt ttaccagccc tttcgttttt aaaaatcaca catcaattat tatcatacag 3107041 atgcataatg attattctgt ctctcttaga ctttattata gagacaaaga aatttacttt 3107101 caagtaaaac atctcgaatt aaagattatt taactttccc aaacagctta cttttcaaaa 3107161 gctgttctca agccggaata cagcgcggac aattctttac tgatccgagg ataatgaggg 3107221 acatgcggca cttgaatatc cgcaggcatc cttttcatga taaaggattg ctcagcctgt 3107281 tcaaaaaacg cccgcagctg gttgatctct tcatcagaaa acggagcaga cggacggcgg 3107341 tgagcttgcg ccgagagcaa atagtaccct aagtgctgag caccggaaat ggcaggccag 3107401 agcgcatccg cattcgcgtg aggaaactcg ccaagcgcct tgtcatacgc atcccgaagc 3107461 ctgacaagac tcacccttaa cttgtgttcg tcggcaattt gcccggttaa cagtttctcc 3107521 ataaactgcc cttccagccg gatgacattc cgcacaagtt ctggcagccg cttggttgaa 3107581 aaccgccgcc acaaaagcat tgttcccaac agcccgatca cgctgccgac agctacatca 3107641 gtcagcctcg ctatcataaa ataaccggcg cccgccccgc catgcatact ttctgtgata 3107701 acaagcgcat ttgcggttaa aaagggaaca gccagcgcat aattgcggac gatcagcatc 3107761 tcaagaagac attgcagcgc tgcaatacaa aacgcaatat aaacaccgcc cggcttaaaa 3107821 aacaggattg cgcctgccag tataacaccg atcaccgttc cggccgaacg ctgaatagcc 3107881 ctgtgaagcg taaaaacaac agtagtgcca agcatgaccg ctgctgccga aagcggaatc 3107941 caataggagc gtgcaaagcc gaatgcgagg gcaaacatat cggcggcaaa cagaacaatt 3108001 ccgtacttta acgctctaat caaaactgga gacttccagt caaaggcatt tctcaaaaag 3108061 taaaaagagg atggcaggcg gcttggttcc ccgtcaagct gcttatcaaa acgtcctgaa 3108121 gcgatataca aaacctcatt gatttcttca aacagcttcc gcctaggctc agattcattt 3108181 tcattaatct gaaacgtatt gaaaacccgt gcattcgcaa gcatatctcc ggtttggcga 3108241 agtgcctttt caatctgcgc ggtctctctg tccggcgttt cagctgaaaa atgaataatg 3108301 gcaataaata tgtcgtcagc tttctcaagg aggcgaaaaa atcgttcatc atgccgcgat 3108361 tttttccgtc tgttcccttt cccaagaacc gtttggcggg ctgttctaag catgagcacc 3108421 gtctgatgct gtgcgttatg aaaacctggc gttccgacgg ctgaaagaca tgcagccagc 3108481 tgatgatatg ttttttgcag caccgctccc tccggtccat gtttgttcca taaccagccg 3108541 attaaagcga tacccatggc gaaaatgccg ccgagaaacg tcagtcccgc tctgaacagc 3108601 gcttgtgaag gatcggccgg cagcccggaa ctgactaaaa aggcaaggac aaaaaacatc 3108661 ggcgcagggc cttgaatgcc gagcgcgcta aaaataaaca tcgccgctgc accgatcagc 3108721 cccaaaacag ccgccatcat ccaaagcatc ccggacaaaa gcgtccctaa accaaatgag 3108781 agggcgatcc caatagaaac caagagcagc ttcaaggcgc gctttttgta cgattcaccg 3108841 cccgcatata aataaacaaa gcctccgata cttgcaatta atccgtaatc cgtgtgacct 3108901 gccaatgcac cgaccagcac aggaaaccct gaagcgaaac ctgatccgat agcctttttc 3108961 caaggaaatg gatttgcatg aatgcgaaag gcatccttca cgataggcat gattctttga 3109021 ttgttcgcag cagttttgtt catttgacaa aatccttttc aatgaatgtg tagaactttt 3109081 ccagtttctt cgctttagta tgcccaaaaa cgcggttagc ttctcaattg gtgcgcacga 3109141 taaaaaaaca gagacttata ccgtctctgc ttcattacat cagtttatta taaaagcggc 3109201 acctgtcagg actgttttgt ccttctgcct tccttcaaga gcaggtgaat aaaaaataaa 3109261 ggataaatca atagataccc attaaacagc caccacacaa gatcaaagtc actgctgaat 3109321 gtccagaatg atagcgcctg cagacctgaa caacaggtca gcacaagaga aatcagcgcc 3109381 atcagcttcc agtcagcacg attcacccgc tgtaggtaca agctgtacaa ccctgtgaca 3109441 gaaatcagga tatccagcgg aaaaaaagac cagttccaag cgatcataaa cggatggtca 3109501 tgatgtttaa aagcccagct ttccggtatg agcgaaaatc cggctgacag ccagtacaag 3109561 ataaaaccga tatcagtcac gagaaaaaac agcttcatat atctcatttg tactgcccgc 3109621 ttttatgtac cggctcagac accgcaacat gctcgatcag gtttaaagac acaacaccgg 3109681 caataatcaa tccaattgaa atgactttca tgacactcac atgttcttga aaaaacaaaa 3109741 aaccaacgac tgtaatcaag acaattccca tccctgacca tacagcataa gcaactgata 3109801 catcaatgga tttaagcgta agcgtcagaa agaaaagact ccctccataa aagaaaatca 3109861 acagcaaact gggaataagc tttgtaaaac cagacgatag cttcatgctg acagttcccg 3109921 caacctcaaa caaaatcgcc aagcatagaa acacccaatt catgtggcat cagcctcctc 3109981 atcagctgtt ataccgttaa acaaaacatc tacaattgat tcaagtacct ctcctgtcgt 3110041 gaactgatgt ttcagcggat attcagggtc atacacttga ttgatgctcc ctatatacat 3110101 gtgaacaaac aggtccggat tgatgtttct gattctcttt tgctgtttgc actcatttaa 3110161 taatgctagg acaatcgccc attcttcctt aataaacgcg tctaatgtaa gccacgcatc 3110221 gtaatggtat ttctttagtt catttaataa tcccatgttc agcagttcca tcccctgcgg 3110281 aaggctgatc agcatttgtt tcaccttttc gagcacattt aaactttcat tttcatagat 3110341 gtctctttct atttgcttca tttcagctat aaattgttcg acaaccgcct caacaagctg 3110401 atctttagat gaataatatg catagagcgt ccgcttgctc gttcccagcg ctgccgccaa 3110461 atcattcatc gtaaatgaaa atcctttctg cttgatcagc cggaaggttt ccgccagaat 3110521 tcttttatcc atattaatcc cccgctttcg gtaccaagaa aactatttcg gtaccaatat 3110581 tatacggcag aaatttatgg aaatcaacaa tatataaaaa aacctctcct attgggagag 3110641 gtttaaaaga cactgcggac caaaccgccg tccgcccgaa gtgccgcgcc attgatcgca 3110701 gaggaaagcg gactgcttaa aaatgtaacg aagtgggcga tttcttccgg acggatcagt 3110761 ctttgaataa tagatgtcgg ccggttttct ttcataaaac gtgcctcagc ttcttgaaca 3110821 gtcaggtttt caccaggata cagcgagttc agcatggttt ccacaccctc tgttaaggta 3110881 gagcccggca tgacggtgtt gactgtgaca ttcgtgccgg ttgccagctc cgccaaactg 3110941 cgggaaatgg acagctgcat cgtttttgtc gcactgtaat gggccatttc ctgtgacggc 3111001 ataatcgccg cttcactggc aatgaaaatc acacgccctt cttttttctc tatcatgtta 3111061 tgcaaatacc tgcgtgtcag ccttacaccg ctcataatat tcacttcaaa aaaacgaaac 3111121 cattcatcgt cgggaatatc aaagtactcc gccggttcaa aaatccctaa attgttgacc 3111181 aaaatatcaa cctctggata tgcctgaaac agctcattgc agccttcttc tgttcccaaa 3111241 tcaaatgcag ccggataaag aaccgcttca gcatgttgtg ttttcagttc atctatcgtt 3111301 tgattcactt tctcttcccg gcgtccgtta atgatcactg ccgcaccttc ttcagctaac 3111361 gaagaggcaa tagcttttcc gatccctgat gtcgaaccgg tcaccagtgc ggtttttcct 3111421 tgtaaattca gcttcattat tcatccctcc gtttttgatt cctcttattt attgacagaa 3111481 atctgattgg tgaaacatct gctctgcaat cagtatgaaa cagctgggat tgaaatggaa 3111541 gtacgcactt tttggtgcct gtggtttgga gaaaaaataa agcagaacct cttaagaggt 3111601 tctgctttat tgtcagtatg tatggagacg gtgggagtcg aacccacgtc cagaaacatc 3111661 gattacttaa gcgtctacga gcgtagcctg catatttatg gtttcactca tcttcttgcc 3111721 tgcgggcggg ccttccgaga gctagtctgt tcatctcttc ttacgttctc agacgggaac 3111781 gcaagcgtag cctacttgga tgtgctcttc acagacacat aggcaatgtc aggaagagct 3111841 cgctgcgctt attaggcagc taatgctacg ttttggttaa aactgttagt tttgccagtt 3111901 atatttaagt gcgtgtttac gagatcgcct ctcggctcgc agctcaagct cgatccatcc 3111961 ctgtcgaatc cgtaacgtcc ccttggtata agggaaatac gggagaaaat atcaagctct 3112021 cactcaaact ggctatagtc ttattataac atgatcacgg ctcttttcaa ttgtcaaatc 3112081 cttcaaatga atggcgtcgt gatctgatcg tgaacacagt atagcacagg cctgattttc 3112141 gaatcaagca ctatgccttt agaagccttt ttgactgtct ctgaacgctc tttcgatttc 3112201 ccgcttcgcg tccttgcgct tcagatcttc ccgtttgtca tagttcttct tcccttttcc 3112261 aaggccgaga agcactttgg caaagccgtt ttttaaatac agcttcagcg gaacgagaga 3112321 atagcctttt tcctttgtta acccgatcag cttattaatc tccttgcggt gcattaacag 3112381 ctttcttgtc cggagcggat cgtggttata gcggtttccc tgctcatatg ggctgacgtg 3112441 catattgtgg agaaacactt ctccccgttc gattttggcg aaggaatcct taaggtttac 3112501 gcggccggcg cgaatcgatt tgatttcggt tccttgcaga acgatgcctg tttcataggt 3112561 ttcttctata aaataatcgt ggttggcttt cttattttga gataatactt ttcctgaccc 3112621 ttttggcatg ccagaacctc ctctctctaa ggaaaaactg tccacctttt gcgatacgct 3112681 ctattttacc aaatgtcacg taccgctaca atgaaaagct gtttccgaaa gaaagcaaat 3112741 agagcgctgc ggccctattt gctggttgag ctgctatttc ttctttttcc gtttctgttt 3112801 cggagcattc tggaagccgc gttttttctt tttcttcttc ggcttagtga accactcccc 3112861 tttttcctca gacggagctg gagaaacagg tgtattggtg ctttgaacac gttttctggc 3112921 aggctttccg cgttttctgc tccggctgct gtccaattct ctcggacgcc gcggagtgcc 3112981 tttcatgccg acaatttcaa agtcgatatt gcgctcatct ttattgacat cgacaacctt 3113041 gactgtgatt tcatccccga tgcggaagac gttgcctgtc cgctcgccaa tcattgcgaa 3113101 atgctgttcg tcaaagcggt agtagtcatc tgtcataaag ctgacatgga cgagtccttc 3113161 aattgtattc ggcagctcga cgaacattcc gaagtttgtc acagagctga tcatgccgtc 3113221 aaactcttca ccgattttat caagcatgta ttccgctttt ttcagatcat ccgtctcacg 3113281 ctcggcgtca actgcacggc gctccataga tgatgtatgt tcggcgatat ccggcaggcg 3113341 ttcagcccac ttttcctgtg tcgcttcatc gaccttgccg ttgatcaaat acgttcggat 3113401 cagacggtga acgattaagt ccgggtaacg gcggatcggt gatgtgaaat gcgtatagaa 3113461 ttccgttgac agaccgaagt gccccaagct ttgcgggtcg tatttcgcct gtttcatcga 3113521 acggagcata acagtagata taaccgtttc ctctggtctg tcacgcacag cgtccagaat 3113581 gctttgcagc gcgcgcggat gaatattccc cgccgttcct ttcaccacat agccaaatgt 3113641 cgtcacaaat tctaaaaact tttgcagctt ttcagcattc ggctcttcgt gaatccggta 3113701 tataaacggg acattcatcc aatggaaatg ctccgcaact gtttcgtttg ctacaagcat 3113761 aaattcttca atcagcttct cggcgacaga gcgttctctg atcacaacgt ctttaaccgc 3113821 tccttcgtca tcaacaagca cctttgcttc tttgaaatca aagtcaacgg cgccgcggtc 3113881 catccgctta tcgcgcagaa tttgagccag acgctccatg tctttgaaca tcggaacaag 3113941 aggctcgtat ttttgtttca gctcttcatc atcatcaaca agaattttat tcacatctga 3114001 atatgtcatt ctttccgttg ttttgatgac actttggaag atctcgtgct ctgtcacctg 3114061 tccctgactg ttaattgtca tttcacaaga aagcgtcagg cggtcaacct ttggatttaa 3114121 ggagcagatg ccgtttgaca atctgtgcgg aatcatcggg atgacacggt caaccagata 3114181 cacacttgtc cctctttcaa gcgcttcttt gtcaatcggc gagttttcgg ttacgtaatg 3114241 gctgacatca gctatgtgaa cgccaagctt gtagcttcca tcatcaagct tcgtcacggt 3114301 aactgcatca tccaaatcct tcgcatccgc accatcaatg gtgacaatca cctggtcacg 3114361 gagatcacgg cggtctttca gatctttttc atcaatcgtg tcaggcgtac ttgatgcctg 3114421 ttccatcgcg tcagctggaa attctcccgg caggccgtgc ttatgaatga ccgataaaat 3114481 atcaatgccc gggtcgtttt tgtggccgag aatggtttca acctcaccct ctgcgttcat 3114541 gcggccttca ggatagctcg tcagcttgac aacaacctta tgcccttccg cagctccatt 3114601 tttcccattt ttcggaatga agatgtcact cgtgattttt ttgtcgtccg gaatgacaaa 3114661 gccgaagttt ctcgtttctg tatacgtgcc gacaacccgc tgaatcgctc tttctaaaat 3114721 ccgtatgacg gttccttcct gcctggagcc gcttgattgt gagttcagac gcaccatgac 3114781 gatatcgccg ttcattgccg tatttagctc attaggcgga ataaacacat cacttaacga 3114841 cgtatcctca ggcagcaaaa aggcgaatcc tttcgcatgg gctgaaatct ttccttttat 3114901 taaattcatc ttctccggaa tgccgtagcg gtcgcttctc gtccgtacga taagcccttt 3114961 ttcttccaag gcgactaacg ctttgacgag ctctttaaac tcctcggctt ccgtaatatt 3115021 taacatctcc tcaagttcct gaacggtcag aggtttgtac gcctcttcct tcataaacga 3115081 gagaagcttt tccataaatg cttctttttc cattatccga cctcctgttg attaccaatc 3115141 gagcttctct aaaaattcat acacatcctg atggacgagg tcacgttctt tgtcgagtgt 3115201 aatgacatgc cctgattcct cgtaccattt cagctgttta tcatcagttt ccacttcgtt 3115261 gtaaataata ttggcgcttt cggtattaat catgtggtca tgacgggcct gcaccacaaa 3115321 tgtcggtgaa taaatcatat cgacattatt ccgcacatca gcaattaagt cttgcagcgc 3115381 cttgagggta ttcatcggcg ttttttcgaa ttctttcatt tcctcttcaa tttgctccgg 3115441 gcttttcccc tcaaactttt tgtaattgcg agcgtatgaa agaacgcctt gatacatgac 3115501 ctcttcactc ttaatatgca tcggtgcgca cattgggaca attcccttta tgggtacagt 3115561 gtaacccaat ttcagcgaaa aaaccccgcc aagcgacagt ccgcaggcag caatgctctc 3115621 ataaccttca gattttaaat attcatagcc atccattacg tttttccacc agtcttcggg 3115681 ccccgtatgt acaagttctt caggcgggac gccatgtcct tcatattgag gcgcgtggca 3115741 cgtatagccg cgttcattca aatatcgtcc cagcatcctt acatccgctg tatttcctgt 3115801 aaagccatgc agcaaaagca ccgctttgtc tccgccttta aatgtaaatg gttttggtgt 3115861 cacaactttc atgctcatgt ctccctttct atctgcacga tcattttagt tttccacagt 3115921 ttaatcagaa aaaaacgttt tgaatatcat ccagaaacgt gaaaaaggcc tgacttcaca 3115981 tcagacctta tacaaacatt gccctatagg atataagcaa gcgcaatcgt taacacgaaa 3116041 aacaagactg ccagcactac cgtaatgcgg tgcaaaatta aatcaagacc tcttgctttt 3116101 tgtttcccga agagctgctc cgctccgcct gaaatcgcac cagataatcc ggcactttta 3116161 ctggattgaa gcaaaacgac aataataagt gcaatgctga cgataaccaa taaggtaatc 3116221 aaaactgcgt gcatcccata cacctccaga ctcactggct acattacttc tattttacat 3116281 gaaaagggtt ggcatgtcac gctgtatcag acgccaaaag gccggataag acgttttatc 3116341 ttggttaccc tattcatatg aaaaggtcaa aggagaaaag cgatgccgct tatcagcata 3116401 gacagcagga aacatctttt ttatgaagaa tatggacagg gaatccctat catttttatc 3116461 cacccgccgg gcatgggacg aaaggttttt tattatcagc gccttctatc caagcatttc 3116521 agggtgattt ttccggattt aagtggccac ggtgatagtg atcacatcga tcagccagcg 3116581 tctatttcct attacgcaaa cgagatcgcg caattcatgg acgctttgca cattgataaa 3116641 gctgtgttat tcgggtattc tgccggaggc ttaatcgcgc agcatatcgg cttcacccgc 3116701 ccggacaaag tgtcacacct tattctgtcc ggcgcctacc ccgctgttca taacgtaatc 3116761 ggccagaagc tgcacaaact gggaatgtat ctgcttgaaa aaaaccccgg tttgctcatg 3116821 aaaatcctcg ctggcagcca cacaaaagac agacagcttc gcagcatatt aacagaccat 3116881 atgaaaaaag cagaccaggc ccattggcat cagtattatc tggattcgct tggctacaac 3116941 tgcattgaac agctgccccg cctagaaatg ccaatgctgt ttatgtatgg cggcctgcgg 3117001 gactggacct ttacaaacgc aggctattac cgaagatcgt gcagacatgc cgaatttttc 3117061 agattggaat atcagggaca tcaattgccg acaaaacaat ggaaaacgtg caatgagctg 3117121 gtgacagggt ttgtgctgac acatcattca taggaataga aaacgcttgg cttccttgcg 3117181 ttttttgtta ctttattgac ttttgtcaac gaaatcatag taaaaaagat cctcaaattt 3117241 caaattaaaa tagtgaagca ttttaccaat cacaagctgc cccggccttc tttctccatt 3117301 cagcacgcgg ctcagtgtgg cgggtgagac tccgatttcc agcgcaagct gattaaggga 3117361 ataatcgtta ttaaccatat actgcaagac ataatcacgt ctaatctgta tcttttctac 3117421 tggcactttc ctcaccttcc attcctgaaa aacttttttc tatactttta cattacggct 3117481 tatgttaact tttgtcaata catttccagt ctacctattc cctttagtca ataaacatac 3117541 taaaatatga gtaacagtga gggacggggt gagatatatg gaaagctttg gcgaacaatt 3117601 acgggcattg cgtgaagaga gaaagttaac agtcaaccag ctggcgactt attcaggcgt 3117661 aagcgcggcc ggcatctcca gaatcgaaaa cggaaaacgg ggcgttccca aacctgccac 3117721 catcaaaaaa ctggcagagg ccttaaaaat tccttatgag gggcttatgt acaaggctgg 3117781 ttacatcgaa gaagtgcatg aagccagggc cccttatgaa acgaagtgca agctgcttga 3117841 aaaagcggag gcctatgacc tgaaaaacct tgcgcttctt gagaacgaaa agtggcaata 3117901 tctcaataaa gaagatttgc tcatgctgga tcattatttt tcgtttattt cagatgaagc 3117961 gaaaaaacgg tctgctgatg actgactctt gatagaaatg tgaggcgata gaccatgtca 3118021 ccgttcggac agcaattacg ggagctgcgc cgcgcccgca aactgacagt gaatcagctt 3118081 gcggtgtact caggcatcag ctcggccacc atttcaaaaa ttgaaaacgg caaacgcggg 3118141 acgccaaaac ccgccacgat taaaaaactg gcagccgtcc tgaaagtgcc gtacgaaaac 3118201 ctaatggccg ccgcaggcca tattcaggcc tttcctgaag aaatccgcga agcatctgaa 3118261 ggctatcaat ccgtttatga aatttaccag acggctgtca cacgcggagc ggagcacctc 3118321 ccgattttca atagtcaaaa atgggaacat ctctcaaagc aggatattga aaatctcagc 3118381 aaatacttcg attttttgtc ttcagaagca aaaaaacgcg cctcttcctc ataatcccct 3118441 gtttctcttt ctatatttta tcaatcacgc ttgcatgccc tccctcgtta tttgcgttat 3118501 aatagtgaca gacgaggtga aaagtatgaa ccaatcagaa atgtgtccta gatttgaaaa 3118561 agcagtcgac atcttaagta aacgctgggt cgctttaatc gtatttcagc tcttgaacgg 3118621 gtcgcagcga tttagcgaaa ttgaagcagc acttccaaat ctaagcggca gagttctgtc 3118681 agaacggctg aaagaacttg agcttgaagg agtagtgaag cgggatgtca tccctgaaac 3118741 tccggttcgc atcgaatatt cattgactga taaaggaaag gcactagcac ccatattagg 3118801 tgagatttct aaatgggcga ctgaatggat tgacccttcc tttcttgact aattgctaaa 3118861 atggttctga tctcaaagac gagaaaagaa ccgtttttta ttttccaggt gaaaaaaaga 3118921 tatctcagcc gatatatagt acatccacac attacgtttt taaaggagac cactatatgc 3118981 gactgacgat ttcccgcaaa ttcagcctgg tatttttgac actgatcctg atcaatttac 3119041 ttgtaggcgg aataggcgtt cttaatatgc agcatatcat tcaaaaaaca gatgaaatca 3119101 acacaaaatg gattgacggc atcaaaggaa tcacttcaat taattatgta accgagcacc 3119161 tgtcttctaa agaaaaggac tttctgattt atacagacaa aagtaaaatg gatacacttg 3119221 atcaagaaat gaatcaaatc atggaagaca ttaaccaaaa gctcgataac tacgaaaaaa 3119281 cgatctccac tgataaagag cagaaactgt tcgagcagct tcaaactaaa gtgaatacct 3119341 atatggatat tcatgcgcaa attatcgaaa gcggccgcac gaatgacatg gacaaagcaa 3119401 gaggtttatt ggttcagact gaggccagct ttgaggatat gaaaaaaaca atcactcagc 3119461 ttgttgactt aaatcaagaa ggcagcaaca cagcggtaaa agaaacgaag gccgtctatc 3119521 ataaagggct catttacact gctttgcttg tggcagcatc aatcctcatc agcattttca 3119581 tctggcttta tatcacgcga aacattgtaa agcctatcat tcgcatgaag gaatctgcca 3119641 atcatattgc cgaaggcgat ttgtcgaacg atatggaggc cctcaactca aaagacgagc 3119701 tgggtgatct gaatgaagcg ctgcaaaaaa tggtagggaa tctgagagat attgtcggat 3119761 attctaaaga catatcaagc cgggttcttt cttcttcaca ggtgcttgca accgcaacga 3119821 atgaaacaag atccggcagc aaacatatta ccgagacgat gaacgaaatg gctgagggct 3119881 ctgaacagca ggcccaagac gcggtgacga ttgccgaatc gatgaatgag tttaccgaaa 3119941 gcattgataa agcctataat cacggcatca caatcagcga tacgtctcaa aacgttctcg 3120001 aactcgcggt aagcgggaac gaaaatatgg ctacgtcatt acagcaaatg aaaaccatcc 3120061 atcatattgt tgaagaagcc gtgcataaag tgagatcact ggaacagcat tctcaggata 3120121 ttaacaagct cgttcaggtc atcaacggga ttgccgagca gacgaatttg ctgtccctta 3120181 acgccgcgat tgaagctgcc cgcgctggag aaagcggcaa aggcttcgcc gttgtggcag 3120241 aggaggtcag aaagctggct gacggcgttt ctgattccgt gcaggacatt acccggattg 3120301 taaacgggac acagcaggag atccacactg tcattacgta cttggaaagc agctttacag 3120361 aagtcgaaaa aggaacggaa aacctgacag acaccggaca ggctatgcag catatcaaac 3120421 aatccgtcac ccatgttgca gacagcatta aggaagtaac ggatggcttg aagcagttaa 3120481 caaaccaatc gattaccatc aatcaatcga ttgaaaatat cgcttctgta tccgaagagt 3120541 ctgccgccgg cattgaagaa acattttcaa ttaccgagca atccgcccat tcgatggatc 3120601 aagtgcttct aaatgctgaa gagcttgagc agctggccaa tgagcttaat gagaagatgg 3120661 gtcagtttac gatttaaaga gaaaaaagag gctggactcc agcctctttt tctattctat 3120721 gcagctgatt gaacatgttt cgccccggtt ctttttttct tcaccggact taatgcccgc 3120781 tccagccaag ccatgagcaa atccgcccct accgccatca ccgcagttgg tatcgctccg 3120841 gctagaataa tcgcagttcc gtttgttgcg tttgagccgc gtacgatcat gtccccaagg 3120901 cctccggcac cgacaaatgt gccgatcgct gtaattccga tggcaatgac gagagccgtg 3120961 cgaaggcccg ccataatgac agaaagtgcg agcgggagct caaccattct gagcacttgg 3121021 aatttcgtca tgcccattgc ttttccagat tctaagtagg catgttcaat actgataatg 3121081 cctgtgtacg tgtttcgaat aatcggcagc agggaataca gaaataatga tagaatcacg 3121141 gtatttgcgc cgagccccat aacaagcatt aagacggcca gcatagcgag cgccgggatt 3121201 gtttgaataa cgtttgttac ggcaaacacc caggctgaca aacggcgaaa atgcgcgatg 3121261 aggattccgg ccggaacccc gacgacagcg gcaaataaaa cgccgtaagc cgacatgaga 3121321 aagtggcggc cgaattcatc catgacgtaa ctgccattct gcgcgtaata cgtcattaac 3121381 tgttcaagca cgttcattga cctcttcccc ctttcacgat tcgaaatagc gatgtttttc 3121441 taaatattcc ttggcaacga cagacggttc tttgagattg ccgtcgactt catagttaag 3121501 ctcctgcatc gtggctgtgt cgatttttcc gagcattttc ttgatgatgc cttcaagttc 3121561 aggatgttct ttgagcacct tttccggaac aaccggagag cagtcgtacg gcgggaaaaa 3121621 ttgtttatca tcctttagca ttttgagacc ataggacttg attcttccat cggttgaata 3121681 cgcaagcaca atgtccattt ttccgctttt caccgcgtcg tacacaaggc cgatctgcat 3121741 cggatacgtg ccgccgaatg tcatgccgta ggttttcgta aaatcctgat agccgtttcc 3121801 tttgagcttc atccaatagt tatcaacgcc cagctttaat tgcggcgccc attttttaac 3121861 gtctgatacg gtctctaaat ggtattggtc ggccagctcc ttgctgactg taaaggcata 3121921 tgtattatca aacccgtagg agtcatacca ctttaaatca tatctttttt taaactcccg 3121981 ctgagtaagc gccagcgctt tgtccggatc tttttcaggt tccattctca acgtgcctgt 3122041 cagcgcgtct cccgtatatc ttgtggccgc aatgtcgatt tccccgttca ttaaagcctg 3122101 ctgctgcacc gcgttggagc caagattttt aatcgttgtt gttttgagat cagtatggtg 3122161 ttcgatcaac tggccaagca tgctggcgat gatttctgat tcgctcatgc tttgcgcgcc 3122221 gattttaatg gtctggtctg cagcagcgct gagaccagga agcgaacagc cgctcagcgt 3122281 cagcgttgcc gcaagtgcta aacctatcat taatttgaga tattttcttt tcatgagccg 3122341 cctccttatg acaattcctt caatctctgc atgccggcag gtgtcagttt tcgttcagca 3122401 actgccagca cataatcaat cacaattgcc aatatcgtga caggtaccgc gcccccgatg 3122461 atatattccg gctgatataa attcagtccg ataaaaatgt aatcacccaa tccgccgcct 3122521 ccgataaagg aagcaagcgt ggcccagccg attaagtaaa tcgtcgatgt tctgattccc 3122581 gccatgatca ctggtgcggc aagcggcagc tccaccaagc ggacttgttc agccggcgtc 3122641 attcctattc ctttaccaga ctcgagcaga tttttgttga cgccgcgaat gccggtatac 3122701 gtgttgcgaa gaatcggcaa tacggaatag aaaaacaaag ccacaatggc cggaaccttc 3122761 cctacaccaa ggagcgggat aaaaaaagcg aggatggcca gactcggcag cgtctgaatg 3122821 atattgacaa tgccgataat ggtgccggct ccttttttca ttctggtaag cacaaccccg 3122881 agggggacgg caaccagcac acctaagatc acagcaatga gcgatatcgt aatatgctcg 3122941 tatgttttat aaagaagctc tcccccattg gtttgcaaaa attgaacaat atgatgcatg 3123001 acttatcgcc cctccctatg acaatgctgc gagctgcttt tcttctcccc agagggagtc 3123061 atacacgatg tcgaccagac ttgccctcgt cacaattccg atcaggcgtc ggtcttcatc 3123121 cacaacggga acatatttga caccccgttt taaaattttg cggaccgtgt cgcgcagcag 3123181 tgtgccgccc agtactgtgt atatatcttc atgtaaaact tcactgacga gattggcctt 3123241 tttccggcat tgatcaatga tttcaacatc gacatagcct tgcagaacgc gctcgtcatt 3123301 gacgaccagc aatgaatcga cccgttcctg cctcatcagc tgaatggcct cagaaagcgt 3123361 tttatccgcg gtgatcgtta caggctgtgt gttcataatc tggtcaaccc gttcaacatc 3123421 cgggctggat gactgaatca gccgctcctt gccgataaat tcctcaacaa attcgtctgc 3123481 cggatttctt aaaatgtcat cgggcgttcc aacttgaacg atttctcccg cttttaaaat 3123541 cacaatccgg tctgccagct taatcgcttc atccatatcg tgggtaacaa atacgatggt 3123601 tttatgtaag gttttttgca gttttttaaa ttcttcctgg agggaatccc tcgtaatcgg 3123661 gtcgagtgcc ccaaacggtt catccattaa gataagcggc ggctccgcgg caagtgcccg 3123721 taatacacca attcgctgct gctgcccccc gcttaattca tgagggtaac ggtctacata 3123781 ttctggcccc atatcgacca attttaaaag ctcacgcgcc cgctctttcc gctgctgctc 3123841 cggccatttc agcagttttg ggacgagtga gatattctgc tgaatggtca tatggggaaa 3123901 caggccgatc tgctgaatca catagccaat tttgcgcctg agctctacag gatcctggtc 3123961 catgatgttt tcgccgtcaa tgaaaatctt cccggcggaa ggctcaatta atcggttaat 3124021 cattttcatt gttgtcgttt ttccgcagcc gctcggcccg ataaagcaga taaattcgcc 3124081 ttttgcaatc ttaagattta cgttgttcac ggcttttttg ccgcccttgt atgttttcga 3124141 gacattttct aatgtcagca aacatcgcac ctccaaaatt aagtttattc aatttgttca 3124201 gtttaaattt aatttttcag acaattgaat gcttcccatt atagaataaa gtttataaaa 3124261 taaaaagttt acaatttgtt catattattt ataaagtatg tgtaaacgct gatttacccg 3124321 cattgacgtg tgttgatctc cttattgctc caatttcctg ccaaattctc ttttgacagc 3124381 attttcgccg tatcaaaaat gtggtatatt gacatcggaa ttgttagctg aaaggatgaa 3124441 accgttggag aaagatccgt taacgatcat tgaacaagcc gaggaccatt ttatagaaag 3124501 aatcgcggaa aacatgcatg catttggaat gccctctacc gtcggacgag tgctgggcat 3124561 tatttatatg aatcgaaaac cgatgacgct tacggaatta tctgaggcca ccggcatgag 3124621 taaaacacgt atgagccagg tagtgcggga aatgcttgat gccaacattg ccgagaaggt 3124681 attcgaaaaa ggcgtgcgaa aagatttata tgaggttgag caggactact atcaaacatt 3124741 tatcacgctg ttttcagcca cctggagcaa agtcgtcagc aaaaacaaaa tgatgcataa 3124801 aaaactcaat cgggagctgc ttagcgtgtt ggatgaagag cttactcctg aagcggaaga 3124861 aaaagtgaat gagctgctga aggaattaaa ggaatggctc gattattata attggctcag 3124921 ccgtttgatt gagttttttg agagcgaaga catttttaaa tatgtgccga agccgtaaaa 3124981 agttcccaaa ttcaattctg ggaacttttt taagtccaat ccaaatggtt gaatatcaaa 3125041 cttcaagaaa acaaacaaaa taatgcataa tttacattaa tttattaatt atccattttt 3125101 tgttgattat tctgactagc tattatataa tctttttgaa atgattatat tagcttagag 3125161 gaggtaatct acatcaaaaa aaagggaatt attactgtaa tgactatatg tttcctatta 3125221 ttttcttctt attactttag caatatttca cctcagaatc cactgttcaa aaaaaatttt 3125281 ttgcaacaat tgtctcccca aggctttggc ttttatagta aaagccctac agaagaaaac 3125341 atttcatttc acacaaaaga aaatttaaag ttacctaatg cacttcccaa taattttttt 3125401 gggataaaaa gagaaggaag agttcaggca atagaattag gcaaaattgt agagaatatc 3125461 gatccaaaga attggaaaac ttgtgaaaac aacaactcct gcacaaattt agagaaacaa 3125521 ataaagccta ttaaggttat aaaaaatgaa gattatatac atcttagcaa aggagaatac 3125581 ctaatatatc gccaaaaacc actctcatgg tattggatag actttaagca aactacctct 3125641 tttgaaagaa aggtgctaaa aataaaaata gtatgaagat attaaatagt ttagaaggtt 3125701 atattgacac ctataatcca tggaaaaata catatgcact ttttagaagt ttacttggtt 3125761 tctcaacatt actagtacta ttattcaata gtactgatat tttatttagt tatagtgcaa 3125821 ataatgtcac atgtgaaaat gtctatatcc ctaccgcttt ttgttttgct aaagaatata 3125881 gtatcaattt tgagattata agatacttaa tgatttttat attaacctta gtggttatag 3125941 ggtggagacc tagatttacc ggtttatttc actggtatat ttgctatagt attcaaactt 3126001 cagctttaac tatcgatggt ggagagcaaa ttgcaactgt tctttctttt cttatattac 3126061 ctgttacatt attagattca aggcgaaatc attggaatat aaagaaaaac aataatgaat 3126121 ctttcacaaa gaagacagta ttgttttata taatgacaat aattaaaatt caagttttta 3126181 tcatttattt aaacgcagct ttagagcgat tgaaaaataa agagtgggca gaaggaacag 3126241 caatttacta tttcttttct gatccggtgt ttggattacc tgaatatcaa cttaacttaa 3126301 tgaatccact acttgaaagc aattttattg ttgtcatcac ttggttagta actatttttg 3126361 agttgttctt agcagcaagc ataatttcaa atatcagaat aaagagaatt gcccttgttt 3126421 tgggaatatt atttcatatt gggataatat tcagcattgg tattgtaagt tttggcttga 3126481 tcatgatatc agcattaatt atatatctgc atcctgtaca acaaaatatc actatgaatt 3126541 ggtgttctcc tttatttaaa tatatatatg taaaaggaaa gagaaatttc aaaagaatag 3126601 gaggtgaatc agtcaagttt cttacaaaat tgtttcatag ctaacattta gataatggag 3126661 aaataactta atggaggtat aataatttga aaagtaaatt acttaggcta ttgattgttt 3126721 ccatggtaac gatattggtt ttttcattag taggactctc taaggagtca agtacatctg 3126781 ctaaagaaaa ccatacattt tctggagaag attactttag aggactttta tttggacaag 3126841 gggaagttgg taaattaatt tcaaacgatt tggaccctaa actcgtaaaa gaggcaaata 3126901 gtacagaagg taaaaagtta gtaaatgatg tagtcaaatt tataaaaaaa gatcaaccac 3126961 aatatatgga tgaattgaaa caatcgattg acagcaaaga ccctaaaaaa ctcattgaaa 3127021 atatgaccaa agcagaccaa cttatccaaa aatatgctaa gaaaaatgaa aacgtaaaat 3127081 actcttctaa taaagttact ccatcttgtg ggctttatgc cgtctgtgta gcagctggat 3127141 atttatatgt tgtgggcgtt aacgcagttg cattacaaac ggctgccgca gtaacaactg 3127201 cagtgtggaa atacgttgcc aaatattcct cttcagcttc taataattct gatttagaag 3127261 cggctgctgc aaaaacccta aaattgattc atcaataatc cattataatt gagtgtcttg 3127321 cggattgctc cgcaagacac tttttcaacg tgaaccgttt aattttttgt aataatgata 3127381 tgaagctagt gttgaaataa ctaatgctag aagaactagc acaatcataa taagaattat 3127441 atattctcct gtaaaaaatg aaagaacagc tattataaaa ccacacacta caagtacttt 3127501 agaggcaaag cgatttccca gtttccaaac agtctcatct tttaatgtcc aaggtgtcct 3127561 caatccaata agatggtttt gttctgctag ctgcatagaa tttccaccaa taattaaaaa 3127621 gataccaaca ccaagcccta ttattaaatc aatattcact tcgtatccta aacttatcaa 3127681 tagagttgag agttgtaaaa tatataaaag gattaacata ttattagaag ctaggaaaag 3127741 caatgcttta tttttttgtg tagacttaat agttaacata taaaaagtaa gataataaat 3127801 aagcataaca acaggtataa taaatattgt taaaggttta gatacaattg cagccggttt 3127861 atttcctgac cattgtatcg gtatttcttc tggaaggtat tgatataata taattgaagt 3127921 caagaaactc aaacatacaa taattatgga aattatattt ttcttcataa atcgttatcc 3127981 cctttattta taaagttaag catccaattt attgagtctt gaagtactgt tgtatttaga 3128041 gagtaataaa taaattgtcc tttgcgatgg tcacttatga cttccgcttg ctttaaaata 3128101 ttcaagtggt gcgaaatact cggtttgctg atattaaaat gctcagcaat atctcccgca 3128161 gtcatatccc ctccttttaa caaatccaaa atttttctcc ttgttggatc tgatatagct 3128221 ttgaaaacat tattcatagc gttttctcct ttacaaaaaa acatttagac atttagatat 3128281 ttgtataaat gtattatttt cattataact tgaatttttt taaaaacaac cctcaaattg 3128341 gttataatat ctgatttttg tattttttca aatactcgga taatcccaac gctggaaaat 3128401 atgtttaaca gatactaaca catgttgttt atttaaaaaa accacctctg ttgtatttaa 3128461 atagaggtgg tttttctatc agctataata aaatttcctt ttttcttttt aatcgggctt 3128521 aatgctcgtt caagccagcc catgaccaaa tcggcaatca ccgccatcag agctgtgggg 3128581 atcgctcccg ctaatataat cgcggttccg tttgtggcgt ttgatcctct gacgatgatg 3128641 tccccgagac cgccagcacc gacaaatgtc ccgatggccg taatgccgat cgcaatgaca 3128701 agcgcggtgc gcaggccggc cattatgaca gaaagcgcaa gcggaagctc gaccatccgc 3128761 agcacttgaa attttgtcat ccccattgct tttcccgatt caagataggc gtgctcaata 3128821 ctgataatcc ctgtatacgt atttctgata atcggcagaa gagaatacag aaataatgac 3128881 aatatcaccg tattagcgcc cagccccatg acaagcatca gcacggcgag catggcgaga 3128941 gccgggatgg tctgaatgac attcgtgacc gcaaaaaccc atccgcttaa tcttctgtat 3129001 ctggctatca ggatgccgag cggaattcca acaatggcgg caaataaaac gccatacacc 3129061 gacatcagaa aatggcggta aaattcctgc agcacgtaac cgccgttttg cgaatagtat 3129121 gtgccaagct gctgtagtac ttccatatga tccacctctt ttcttagtca aaataatgat 3129181 gtttctctaa aaattccttt gctacgacag acggctcctt cagcttgcca tccacctcat 3129241 aattaagttc ctgcatcgtt tccgtgtcga tttgcccaat cagcttattg atcacacctt 3129301 caagttccgg atgctcctta agcacctttt ccggaatcac cggtgaacag tcatacggcg 3129361 gaaagaaacg cttatcgtct tttaagattt tcagatcata tgctttaatc cgtccatccg 3129421 ttgaataagc caaaaccgca tccattttcc cgtttttgac tgcgtcatag actagcccga 3129481 tctgcattgg ataagttgtg ccgaactcaa agccatatgt gctgacaaag cctttatacc 3129541 cgtcgccttt tcgtttcagc caagcattgt cgacgcctaa tttatattgg gaagcatttt 3129601 tcttcaggtc agacacggtg ttaatatgct ccttttccgc aaactttttt gttacggtga 3129661 aggcatatgt gttatcaaag ccgtaggaat caaaccattt ataagaaaag cgcttttgaa 3129721 actcgttctg cacaatgttc agcgcttttt tcggatcttt ctccgcttcc ttgccgaggg 3129781 tgcttgttaa atctgttccg gaatagcgcg tggctgaaat atcaatgtca ccgcccagca 3129841 tcgcttggtg ctgaacatag tttgagccga ggtttttcac taaagcagta ttcaaatctg 3129901 tatcatgttc aataagctgc gcgatcatat tcgctacaat ttctgattct gtcatgctct 3129961 gcgccccgat tttgatcgta tcgtcagaag cgccgcctag acccggcaga gagcagccgc 3130021 ctagcagcat gacaaagacg agagcaaacg cgccaagcca tttgattttt gtcattttca 3130081 acagtgccaa ctccttacga tacttccttc atcccttgca agcctttcgg cgtcaccttt 3130141 cgttctgtca cagccagaac ataatcaata ataattgcca gaattgtgac aggcacggca 3130201 ccgccaatga tatattcagg ctggtatagg ttcagtccga taaaaatata gtccccgagg 3130261 ccgcctcccc cgataaacga cgcaagtgtc gcccagccaa ttaggtagat cgttgatgtg 3130321 cggatccccg ccatgatgat gggaatcgcc agcgggattt caacgagccg aatctgctcc 3130381 cagccggtca tgccaattcc tttccccgat tccaggaggt ttttatttac acctttaatg 3130441 ccggtatacg tattgcgcag gatcggcagt accgaataga aaaataaagc gacaatcgca 3130501 ggcacttttc ctacgccgag aagcggaata aaaaaggcta aaatcgccag actcggcagg 3130561 gtttgcacaa tgtttacgaa accgataacc gcacctgcgc cttttttcat tctggtaaga 3130621 gcaacgccga gcggcactgc aacgataatg cccaatacaa cggctatgag tgaaatatat 3130681 aaatgctctc ctgttttata cagcagctct ccgccgttcg tttgcaaaaa agtcatcatt 3130741 tgattcatct taaaagagct cctcccctgg tcagatcgtc atgagctggt tttcctcgtc 3130801 gccccaaatg gaatcgtata cgatatcaac gaggctcgct cttgtcacaa tccctgctaa 3130861 atggttctgt tcatcgacca ccggaacata cttgatcccc tgcttcaaaa tttttcggac 3130921 tgtatcgcga agaagcgccc ctttttgaac ggtatatata tctgaacggt atacatcgcc 3130981 aacgatgctc gcttttttgc ggttttgatc aatcatttcc acatcaacat agcccttcag 3131041 cacgttttgc cggtccacaa cgagcagcga gtcaacacgt ttttctctca tcagctgaat 3131101 cgcctgagaa agcgttttgt ccgcagatac cgtcaccggc gttctgttca tcatttgctc 3131161 tacccgctcg atatccggtc ttgactgaat caggcgctct ttcccgataa attcttcaac 3131221 aaactcattt gccgggtttc gaagaatctc atcaggtgtg ccgacttgaa cgatttctcc 3131281 cgcttttaat atcacaatcc tgtcagcaag cttaatcgct tcatccatat cgtgggttac 3131341 aaacacaatc gttttgttta aggttctctg cagttttttg aattcttcct gaagggaatc 3131401 acgcgtaatc ggatcaagcg ctccgaacgg ttcatccatt aaaatgagag ggggttccgc 3131461 tgccagggcg cgcagcacgc cgattctctg ctgctgtccg ccgctgagct catgcggata 3131521 acggtctaaa tactctgggc ccatatccac aagctttaac agctcgcgcg cccgttcttt 3131581 ccgtttttcc tcaggccatt tcagcagctt tggtacgagt gagatgttct gctggatggt 3131641 catatggggg aacaaaccaa tctgctgtat cacatagccg atttttctcc tcagctcaac 3131701 cgggtcctgt tccataatat tttctccgtc gataaagatc cttccagacg atggttctat 3131761 cagtctgttg atcatcttca tcgtcgtcgt ttttccgcag ccgctcgggc cgataaaaca 3131821 gataaattca ccttttgcaa tatctaaatc aatgctgttc acagcttttt tgccgccttt 3131881 atatactttt gacacttgtt ccaatttcag caatccgtgc acctccgcag gtttccttta 3131941 aattttctga aaagtataat ccttattata gtttgaactt tgtaaaataa aaagtttaca 3132001 atgtgttgaa attatatgtt atttatagat tatttattgt tatgaccgag acggaaaggg 3132061 tgttcttaca attactccgg atacctccca cttcctctgc attcagctat tttcaacacc 3132121 aggaagaaat atgatatatt gacaccatca attgccattt gaagggatga tcagctgtga 3132181 aaaaaaccgc tctcgacatc attgaacatg ctgaagagca tctcattgag aagattgccg 3132241 aaaatatgca tacgtttgga atgccttcaa ctgtcggacg tgtgctcgga attatttata 3132301 tgaatcgaaa accaatgacc ttaagcgagc tctctgaggc aacgggcatg agcaaaacac 3132361 ggatgagcca ggttgtccgg gaaatgatcg atgccaatat cgccgaaaag gtgtttgaaa 3132421 aaggcgtacg aaaagacctt tatgacgtcg agcaggatta ttatcaaacc ttcatttctt 3132481 tatttgcggc gaattggaca aaggtcgtga gcaaaaacaa agtgctgtat aaaaaattaa 3132541 accgggagct gagtgatctt ttacaaaggg acgggcttac cccggaagcg gaagagaaag 3132601 tcaatcagct gctgaatgaa ttaaaagaat ggcttcatta ctatgattgg ctgagcaggt 3132661 tgattgaatt ttttgagagt gaggaagtct ttcggtatgt gccgaaaaca aaagaatgca 3132721 gctctctaaa ataagagagc tgctttttgc atcatgaagt taagaccgga aacatgcctt 3132781 tcagcccggc accaatcatc ccgaccgcaa ccacggctaa gattaatccc atcagtctgg 3132841 taatcacatt catctcggtt tttccgagtt tgctgctgat aaaagcagaa tagtggaaaa 3132901 agagaaaggt cagggcaata acggcggcta tgccgatcat gacagccgca taatgaccaa 3132961 tgccgctatg tccggcggaa aggctcatca ctgttgcaat cgttccgggc ccagcaatga 3133021 tcggaatgga taaaggtgtg actgatatat ccgctttttc cttgctttcc ttatgttcat 3133081 catggtgaag agattgcacg tgcgattctt tcgcattcaa tagattatag gcaatgccga 3133141 aaatgaatat gccgcccgcc actcggagcg cgtgaatgtt gatatcaaac agtttaaaga 3133201 taagatgacc gaaaaccaaa aaagctgcga gaataaaaaa ggataaaata gctgccttcc 3133261 gggcaatcgc ttttctttcc gctgcagtat agccttctgt cagcgtcaga aatatcggta 3133321 cgtttccgat cggattcgat actgcgaata aagaaatgaa gacgtgaacg ataaatgaga 3133381 acatcatata cctccttgtt gatagtctct gcacaggaaa tagaatgatt ctccaccctt 3133441 ttacccggag gcgatttccc ggtaaacctt tatagcctgt cagaaacgcg ccatgctaca 3133501 atgaagtgac aaattgaata ggaaggacgt atacagatgt tcaaaaaaat tgcggcagat 3133561 gccttgggct tatctgatat cggaaaaatt atcgaacctc aggactatga caaaacagac 3133621 gcagatgact atgtcatgca tgaagataat gagaaaattt atttcttgat taaaacaaaa 3133681 gcagacgagt attgctttac gaacctggcc ctgatccatg tggacggcga acgcgccact 3133741 tcctcaaaac gaacgttgaa acgctatcct tattcgcaat ataaaatctc tgacgttttt 3133801 cttgaaactg ccggaaaagt ggatttggat gttgaaatta agttcaagct gggcggtgaa 3133861 caattcgaca ttgatgtcca caaagaccag attgaaaagt taaaagacct ttataaagca 3133921 ctgcttcgca tcgctgaaac aacctatgaa aatgacattt taatcaatca agcggagcaa 3133981 agcttagata aagcagtgac gattcttcac catacccgcc ctgagcacgt caatattgaa 3134041 acgcaataca aagagctgac cgaattcgga ttcacttggc tgacatccgt tcgctcgcag 3134101 tatcatatta aggattttgg ggatgtattt gagaaatata ttaataacta gataaaaaaa 3134161 gacacagctg ctatcgtgct cgtgtctttt tttgtatgaa tattgattac tttacaactt 3134221 ttttctttta taataaaact attagtctat tttccctata ttacagataa aggagttatt 3134281 ttatgtattg tcctcaatgc ggccatcaaa cagatggcgg aaatttttgt gagaaatgcg 3134341 gatcaccgct ccccggtcaa tcaggccacc agcatgcagc tcaaactgga gccgctgcaa 3134401 agcaagcagc aaaacagttc ggttcatttg tcttatccgt cctgaaacgc ccttatcagg 3134461 aatgtaaagc aacaggcgga gaacagctga tcagcgcaat cattacgatg gttcttttca 3134521 gtttgctgac ccctttgatg ttttatattc ttttttcaga cggtcccgga agcgtaagct 3134581 ttacagcaat cttcttagag ccaaccattt attttatttt atttctattt ggcctgcatg 3134641 catgcatctt tttcgccctg aaaatcgcgg gaaaccaagt gtctttcaag gattcattct 3134701 caagattcgg agcatttctt attcctttta cggctatttt gattcttgcc cttttcttct 3134761 ttttattaca tacagacatt tgctttacca tattagccgt tggtttaatc ggtgcattct 3134821 tcgccattcc tcctgcgatg ctgagcagtt accagcattc atataaaggg aaggttgatt 3134881 tcatttactc aacgattgtg atttatctga tcatctgcgt tacatttcag cttattatcg 3134941 aacactatgt caaagaaatt ttccgttata tgctctttta aaaacaaccc catcacctgc 3135001 tggtgatggg gttgttttat tgaatagacg ttaagtaaat tcttccgttc ttcactacgc 3135061 cggtgtaggt ccagttatat gttctgagct ttggactgcc gcctgatttt gtgatataga 3135121 attcttcata cgtcttaatc gtgatagccg acccattttg gctccagctt ttcacttcat 3135181 agttattaaa gtcttctgtt gtcccctctt tatttaattt cgacacgaga tgctgctggt 3135241 cggaataaag ggaactgcct ttttcaaggc tgtcttccat cagtgagaaa ttattttgat 3135301 tcacggcatc tgcctgactt tgcagataac tgcccataaa taatgtcact tgttcatctg 3135361 taacatcgcc gcttgcagag ctttcactgc ctttgttttt cgagccagcc caggcggaag 3135421 tgtatgtctc tggtttatca tttttgattt tctttatatt tgtgcctgca gattcgaatg 3135481 ttgattctgc atcttcgaaa atccactttt tctgtttttt atcatatgaa agaagatatt 3135541 cataactcgg actgtcgtca gtcatttcag actttgtata gtcgttatac gaagaagact 3135601 ggtgaagttc ttttcctgtt accgatacct gccacgttcc gtcgtttttc tgagagaggg 3135661 caaatgtgtc caggtcaaaa tcagtttcca agtatctatc ttttaagtat gaatccgcgc 3135721 ttttcataga atcgacggtg tccttcgtct ccgccttcca attggcactt gcctctgtca 3135781 tctgggctgt attcccatca gatagagctt tggagtattg ttttgttgtt ttgacaattg 3135841 tgttcataat ctgttcctgt gtatcttgat caggaattaa cgttaactcc atttctttat 3135901 catcgatcgg aacgccggca gtttttgttt ttccccacgg aaattctgcc tcgactgaag 3135961 ctgtcattga tccatctgtc agcagcggac catatgttac ggatttgaac ggatctttat 3136021 gaattgattt accgttaatc agcaaatctc ccttcccgct cttgatgtca ttcgctaagc 3136081 tgaatgtcac atcgtctgct tccaatgaga gatcaacacg aaagctgcta tcgccaatcg 3136141 cctgaatgtc ttcctttttc acaaggtcaa cgacatcgtt tttcagtttg gctgagactg 3136201 tatattcgcc gggaatgtac ggaccaaggg tttgtgcttg atctgctttc tttacagatc 3136261 cggcttcctc tttattgaca tatagatcgg tatttttata attgctgctc acttcaaaat 3136321 aaacaggtgc tacctttaag tcataatggt caaataccag caggcttttc ccgtcttttt 3136381 ccgcatatac gatatccttc tgggctgttt catcacgcag cgatgcaaaa agttcatctt 3136441 ttttgtctgg atgatccttc aaatatgtaa gaaacggttt tacattattt ttagtgagtt 3136501 taagattgtc atttaccggt gtaagcagag tcgcgatttg gtcctgatcc ccatcattta 3136561 cggcctgttc aaacttgtct actaacctat cctttgaagt aaaatacgct ccggttttat 3136621 atgcggcgaa taatataacg cacgccgcgg caatgctgct ccataaaatg atggttttct 3136681 tagggatcgg ttttcgcgga gcctgcctcg tttctgcagt gctagctgtt tcttgatttg 3136741 cctgtttgct gccccctccg atcggggtgc cgcattgttt acaaaacttg gctccttcat 3136801 tattctggga gccgcaattc ttacaaaata acatgacttt cctcctattc tactaatttg 3136861 ataacattta ctgcttttca tattttataa taaaacagaa tgaaattggg aacgaatgaa 3136921 aaaattaaat gtctatcaga ctaaaaaggt ggaatgaata tgcaaaagct caggattgaa 3136981 ttaggagaag aaacaaatga cgaattatat gatctattgc tgctcgccga tccatcgaaa 3137041 gacattgtag atgaatatct tgagagggga gaatgttaca cagcttgggc cggtgatgag 3137101 cttgcagggg tttatgtatt gctaaaaaca aggccgcaaa cagttgaaat tgtaaatatt 3137161 gcggtaaaag aatctcttca gaagaaaggc tttggcaaac agcttgtact tgacgccatc 3137221 gaaaaagcga agaagctggg ggcggacacg attgaaatcg gaacggggaa ttcgagcatt 3137281 catcagcttt ccctctatca aaaatgcgga ttccgcattc aggcgatcga ccacgatttc 3137341 tttctcagac attatgatga ggacattttt gaaaacggga ttcaatgccg cgatatggta 3137401 aggctttatt tggatctctg aaagcataaa aaagccgccg agagaaaatc ccggcggtct 3137461 ttttattact tgtttaagtt gtagaaagag ttgataccgt ggtattgagc agtttcagcc 3137521 aactgatctt cgatgcgaag aagctggttg tatttcgcaa cacggtccgt acgagacgga 3137581 gcacctgttt tgatttgtcc tgcgtttgtt gccacagcga tgtcagcgat tgtgctgtct 3137641 tcagtttcac cagaacggtg agagataaca gctgtgtagc ctgcgcgttt cgccatttcg 3137701 atcgcatcga atgtttcagt caatgtaccg atttggttta ctttgatcag gatagagttg 3137761 cctacgccgt ttttaatacc ttcagaaagt tttttcgtgt ttgtaacgaa gaggtcgtca 3137821 ccaacaagct gaactttttt gccaagacgc tcagtaagaa gcttgtggcc ttcccagtcg 3137881 ttttcgtcaa gtccgtcttc gatcgagatg attgggtatt tagaaacaag ctcttcatac 3137941 cagtcaacca tttcagcaga tgttttcaca acgccttcgc cagacagatg gtatttgccg 3138001 tcttctttgt tgtagaactc agaagatgca gcatccatag caagtttaac ttcttcgcca 3138061 ggtttgaagc cggctttttc gattgcttca acgattgttt gaagcgcttc ttcgttagaa 3138121 ccaaggtttg gagcgaatcc gccttcgtca cctacagcag tgtttaagcc ttttgcgctt 3138181 aatactgatt tcaggctgtg gaagatttga gcgcccatgc gaagtgcttc acggaagtta 3138241 ggagcaccta caggcatgat catgaattct tgaatatcca cgttgttatc agcatgctct 3138301 ccgccgttta cgatgttcat catcggtaca ggaagcgttt ttgagttgaa tcctccaagg 3138361 tattggtaaa gaggaatctg taagaaatca gcagcagcac gcgcacaagc catagatacg 3138421 ccaaggattg cgttcgcacc aagtttgcct ttgttttcag taccgtcaag ctcgattaaa 3138481 agctgatcga ttgcgttttg ttcagttaca tcaaagccaa gaagctctgg agcaatgatt 3138541 tcgtttacgt tgttaacagc tgttaacacg ccttttccaa ggtaacggtc tttgtcgccg 3138601 tcacgaagct caaccgcttc gtattcacct gtagaagctc cgcttggcac taatgcgcgg 3138661 ccgaaagctc ctgtttctgt atatacttca acttcaactg ttgggttgcc gcgggagtct 3138721 aatacttcgc gtgcataaac atcaacaatg tatggcatga gttttgtctc tccttttgat 3138781 tttcaaatta tttttgaatt aaagatgttc ctgtcatttc tttcggtttt tcaacaccaa 3138841 gaaggtctaa taacgttggt gcaaggtcgc ctaggattcc gccttcacgc agcgtaatgc 3138901 cttctttcgt tacaatcaca gggactgggt ttgttgtatg cgcagtgtgc ggttcgcctg 3138961 attctgtaat cagaatgtca gcattaccgt gatcagcggt aatgatagcg tgtccgcctt 3139021 tagcaaggat cgcgtcaacg acttcgccca agcattcgtc cactgcttca attgctttaa 3139081 ttgttggttc aaccattccg gagtggccga ccatatcagg gtttgcgaag ttaagaatga 3139141 tcgcgtcatg cttgtcagct tcaatttctt tgacaagcgc gtctttcact tcatacgcac 3139201 tcatctcagg cttcaagtca tacgttgcaa ctttaggcga gttgatgaga atacgctctt 3139261 cacccgggaa ttcagcttca cggccgccgc tcataaagaa cgtgacgtgc ggatactttt 3139321 cagtttctgc aattcgaagc tgttttaacc cgtgctgaga taatacttct ccgactgtgt 3139381 tatcaagatt tatcggttta aacgctacat agccgtcaac tgtttcactg aagtgagtca 3139441 ggcagacgaa atacaggttc tttggataat tctcgccgcg gtcgaagtca cggaagtctt 3139501 tgtttgtgaa cgtgttggaa atctggatgg cgcggtccgg tctgaaatta tagaaaatca 3139561 cagaatcgcc gtcttggatt ttcgcaacag gctcaccgtt ttcttttgtg atgacagatg 3139621 gaatcacgaa ttcatcgtag ataccatttg catatgaatc atcaacaaca tccagggcgc 3139681 tgcggtaaga tgggccttcg ccgtacgcca ttgcgcggta cgctttttct acacggtccc 3139741 agcgtttgtc gcggtccata gagtagtaac gtccggaaat gctggcgatt tcacctacac 3139801 cgatttcctt gatttgatcg ttcaactggt tgatgtacgt tttcgctgtc tgcggaccta 3139861 catcacggcc gtcaaggaag ccatggatat aaacctttgt cagcccttct tttttcgcaa 3139921 gctttaacag tgcgaataaa tgattgatat ggctgtgcac gcctccgtca gataaaagac 3139981 cgaacaggtg caaggctttg ttgttttctt tcgcgttgct gatcgcgtca aggaatgttt 3140041 gattgcgttc gaactctcct tcacgaatgg caacatttac gcgtgttaag ctttggtaca 3140101 caatacgtcc cgcaccgata tttaagtgac ctacttcgga gttccccatt tgcccttcag 3140161 gaagacctac agcctcgcct gaagcagtca aagtttgatg aggatactgg ttccaatagc 3140221 ggtcaaaatt cggttttttc gctaaagcga ctgcgttccc tactgtttcg ttacgtaatc 3140281 cgaacccatc aagaatgatg agtgcagctg gttttttact catattgacc ttcctccaat 3140341 aattgaacga atgactgtgg ctcaaggctc gcgccgccga ccaaagcacc gtcaatatcg 3140401 gactctgcca tatattcttt aatgtttgca ggctttacgc ttccgccata ttggatgcga 3140461 agcttgtctg cagcttcttg gctgaagctt tcagcgacgg ttttacggat atgcgcacac 3140521 acgtcattcg catctttcgc tgtagaagat ttgcctgttc cgattgccca gattggctca 3140581 tacgcaataa cagaagcagc aacttgttct tcagaaagac cagcaaggcc ttttttcact 3140641 tggtcagcaa caagatcatt tgttttgccg gcttcacgct cttcaagcgt ttcacctaca 3140701 cagatgatcg gcacaatgcc gtgtttgaaa gctgcgtgtg cttttttgtt aactgtttca 3140761 tcagtttcag cgaacatttc acggcgctca gagtggccga tgacgcagta gtcaacgcca 3140821 aggtctttca gagcaaccgg gctgatttcg cctgtgaacg cgccgctttc ttcgaagtgc 3140881 atgttttgag cgccgacttt taggtcagtg cctttcacag cagaagcaag cttttctaag 3140941 aaaagcgctg gcgcgcaaac aacagcttca gctttgtctg ctgctggaat ggaagatttc 3141001 acttcttcaa cgaagctgac agcttcgccg agtgttttgt tcattttcca gttaccggcg 3141061 ataattggtt ttctcatctg ttccacttcc ttatagcagt tttgagatta tttatcgttc 3141121 agtgcagcta cccctggaag ctctttgcct tccataaact caagggatgc gccgccgcct 3141181 gttgagatgt ggctcatttt gtcagcaagg ccgaattttt caaccgctgc cgcagagtct 3141241 cctccgccga tgacagagta tgtatctttc gcctctgcca atgcttccgc aaccgctttt 3141301 gttccttgag cgaacaagtc gatttcgaat acgcccattg gtccgttcca cacgacaagt 3141361 ttgctgtttt tgatgacgtc agcatacgtt tcgcgtgttt tcgtaccaat gtcgattgct 3141421 tctaaatcac tagggatttc agagatcggc acaattttca cgtttgcatc gttagagaaa 3141481 tcatctgcaa cgagtacatc ttcaggcatg tagaagttaa cgcctttttc tttagcgcgg 3141541 tccataaatg atttcgcaag ctcgatttta tcctcttcaa gaagagattt cccgacttca 3141601 tagccaagcg cttttacgaa agtataagca agacctccgc cgatgatcag gttgtctact 3141661 ttatcaagaa gactttcgat tacaccgatt ttgtctttta ctttcgctcc gccgatgatc 3141721 gctgtgaacg ggcggtcagg attggaaacc gcttttccaa gtacatcaag ctctttttcc 3141781 attaagaaac ctgcaactgc tggcagatgc tcggcaattc cagctgtaga tgcgtgagca 3141841 cggtgggcag caccgaatgc gtcatttaca tatacatctg caagctcagc aaatgctttt 3141901 gcaagctcag gatcattttt ctcttcacca ggatagaaac gtacgttttc caatacaaga 3141961 acgtctccgt ccttcatctc agaaatttgt gcttttacag catcgccgta tgcttcatcc 3142021 gcttttttca cttctttgcc aagcagttcg ccgagacgtg cagcgacagg agttaaacga 3142081 agctcctcaa ccacttcgcc tttcgggcgg cctaagtggc tcgcaagaag gacttttgcg 3142141 ccttggtctg caaggtgttt gattgttgga agcgcagcac ggatacgtgt atcgtctgtt 3142201 acttccccgt ctttcattgg aacgttaaag tcaacgcggc agaatacaac tttgcctttt 3142261 acgtcgatgt ctttgagagt ttttttattc atgcctagga gatcctcctt caaaatggtt 3142321 tgcatacagc acgaaaaacg tgaaaccgtc tgttcaagcg ataactccgc tagggcagat 3142381 cgcagtcttt ttcggcacag ggcagttcgt ctaaaagcca gggcagcggc cttaggcgaa 3142441 agcgccggca aagctgctta aaacgcggtc gtttctctat cacagagcgt tttctgaaag 3142501 ccggtcttca tggaaaaagg gaaagggagt ccgtcccctt cccttgtccg ctttcattat 3142561 agcgcttcta ttcgaaagaa ccaagtcagg tcctttttca gctataaatt aaagaccttt 3142621 ttttgcgatg taagctgcaa ggtcaacaac gcggttagag tagccgcttt cgttatcgta 3142681 ccaagagatt acttttacca tgctgccttc cataaccatt gtagaaagag catcgattgt 3142741 agaagagttt ttgtttccgt tgtagtcgcc agaaactaat ggctcttcgc tgtagccaag 3142801 gattccttta aggtcgcctt cagccgcttc tttaagagct gcgtttactt cttcagctgt 3142861 tacttcttgg ttcagttcag caaccaagtc aactagagaa acgtttggag ttggaacacg 3142921 cattgctcca ccgttcagtt tgccttttag ttcaggaaga actagagaaa ctgctttagc 3142981 agcaccagtt gatgttggga tgatgttttc agctgctgca cgcgcacgac ggtagtcttt 3143041 gtgcggaaga tcaaggattt gctgatcgtt tgtgtaagag tgaacagttg tcatcatacc 3143101 gcgtttgatg ccgaatttat cgttaagtac ttttgcaaac ggcgcaaggc agtttgttgt 3143161 gcaagatgcg ttagagataa catcgtggtt agccgcatcg tatttatctt cgttaacacc 3143221 cataacgatt gtgatatctt cttcgttagc aggagcagag atgattactt ttttcgcgcc 3143281 agcttctaag tgtttcgcag cgtctgcgcg ttttgtgaag aaaccagtag attcaactac 3143341 gatttcaacg ccttgtttgc cccagctaag tttagcagga tcgcgttctg cagaaacttc 3143401 aattgttttg ccgttaacaa caaggttgtt accgtcaact gaaacttcag cgtctaattt 3143461 tccgtgtaca gaatcatatt gtaaaaggtg agccagcatg ttagcatctg ttaaatcgtt 3143521 aaccgctact acctcaactt caggattgtt taatgctgcg cggaatacgt tacgtccaat 3143581 acgaccaaaa ccgttaatac cgacttttac tgccatgatt gtttcctcct ttaaataagt 3143641 gagagatatt tatattgagg gattattcat cccttaataa cttctttgcg gctccttcgt 3143701 ctgtgacgag aaccgtgttg cgtggctttt taaagtaagc ctcgatcgct tcggcttttg 3143761 atgatccgcc cgctaccgca ataatatcgg ggatggcgtc tatgtcatcc agctgcattc 3143821 cgacagaatg cactttgtga accacttcgc cgtccgcgtt aaaatagtag ccgaacgctt 3143881 ccgtcaccgc gtcgttatca tctattttct ttaaatcttc taaaggcgtg tttctgcgct 3143941 gagccatagt tttagcttcg ccgattccgt gaaccagcat actcgctgat ttaatggtgt 3144001 tcagcacctc tttgacagaa ggctcttcaa taatagatga ataggcgcct tgtgacagct 3144061 gtcccggaac aaacaaaagc cggtaagtgc ctgaagcctt ctccgccata tgcgcgcata 3144121 tggtgttcgc ctggtttttc acgtcttcgc ctaaaccgcc tcttgcaggc acaaacaaaa 3144181 gctcgcggtt tttagaatcc ggcgtcatca tttcggcgac agcttcaatt gtcgtaccgc 3144241 cagttacagc gacgatattt ttgcctgaaa atcttttttt catacatgcg acagccgctc 3144301 ttcccatttc ttttttgacc catggggatt gatcgctgtc tccggatacg ataatggcat 3144361 cctttagatt taaacgttct tttaatgtct tttccaaaag agtcaaacct aaaacatctt 3144421 tcatcgtatc ttccaaaaca gaaagcagtt catagccctc ttctgtcaat gtcatgccgt 3144481 ttgtcttaat atcgaccagg ttctgttcct ttaaaaactg aacctcgccc ctcagcacac 3144541 gctcgctgat tccgagactg gcagacaggc ttcttcgccc gatgggttct gtcagcctga 3144601 tatactgcaa gatttcaaac ctcttttgca taacgagcag aagatcaggc aataattttt 3144661 tttgagcttg tattaactgg ttcatgactc aaacgttcct tccttttttg ctggacatta 3144721 tatgtcccgc tatgacaaaa aacgtcccgt catagccaaa aaaaatcatt tctgctttct 3144781 ttaattattt taacagggtg gaattgttta ttcaactgtt aagagccaat tcatcgacaa 3144841 tattcgcaga gttttcatgc cgcgtcgttt tatccagcaa tattttatcc tatatatctt 3144901 tatcttatac agaaagcgcc aaatggtgca tcccaatata aacagccctt cccgtagaaa 3144961 gggctgtttc attaaagcgt tttcatttta tccaaagctt ttcaatttcc tcgagcgatt 3145021 tgttcttcgt ttctggacag atcgtaacga caaacaggaa acaaaggatg ttaatcaccg 3145081 caaagatcca aaatgtatag gcgagcccga aagaatcgat catcattggc acaaactgtc 3145141 cgatcgccca gtttgctccc cataaaaaga tggtcgcaat gcccgcggcc cgcgcacgca 3145201 gatggttcgg gaagatttca gaaatcataa tccatgtgat cggtccgacc gagacacaga 3145261 aagcagcgac aaaacctaat ataaggacga tcatcatgat cccgcttgtt aactcaaaat 3145321 aaaacgacgt cccgattaaa atcataaaaa tagccataaa agcagaaccg atggacatca 3145381 gtttttttcg tccgacttta tcaatcagca acaccgcaat aacggtaaaa ataacttcta 3145441 caaccccgac gatacaagtc gtcacaaatc cggcgttttg cccgaatccc atcattttaa 3145501 agatttccgg cccgtagtaa gtaatcgcgt tcatgccgat gacttggtta aacagcgcca 3145561 gcaggattcc aatgacaagc gcctttctga gacccggctt aaacagctgg gagagcgacc 3145621 ccatttgttc tatttttaaa gagttctcaa tgttctttaa ttcttctttt gcaacagttt 3145681 ctccattaat acgtgtcagg atctttaaag cttcatttgt tttgcccgct ttcgccagcc 3145741 atctcggact ttccgggacg acgagcagga caaggaaaaa aatgacggat ggcaccattc 3145801 cataagcaag catccatctc cagccggtgt gcacgcccca ttcgtatgtt ccggaccgct 3145861 gcacagctag attaataaag tatgttgcgg aaatacccag tatcgtaaag agctgatata 3145921 acgaagataa acttccgcgt atagcgggcg gtgccgcttc tgtaatatac gtaacagaga 3145981 gcgatgagcc catcccgatt cccagccccc cgataatcct tgcaatgatt aaggtggaca 3146041 cgtcttgaga aagcgctgaa acgattgctg atatcgcaaa taacaaagcg gctgtcatta 3146101 aaatttttct ccggccgaat ctgtcactta aaaatccgga tatcccgacg cccacaactc 3146161 ctccaatcat aatgcttgaa atgacaagtc cctccataaa cggactcagg ctgtataaat 3146221 ctttcagaaa accgatggcg ccagaaatca ctgccgtgtc atagccatac aataagccgc 3146281 caagccccgc cgcacatgag atcaaaatga caaatcccat tgaatggctt cttgttacag 3146341 gaacatttgg ttctaattga gttggagtat tcttcatttc cctgccctcc cgaatgttga 3146401 gtaaagcgtt ttcatttaaa ccttcaattg tacgtactta tattaaaatt taacgaaaat 3146461 tacatttaat tagtacgtac aaatatagaa taatcttgtt tgcattttct gtcaatgttt 3146521 tcttacaaag aacgctgtga tatactgaaa tttgtccgta tacattttgg aggaatggat 3146581 atgttaccaa aatacgcgca agtaaaagaa gaaatcagtt cttggattaa tcaaggcaaa 3146641 atactgcccg atcaaaaaat ccctaccgaa aacgaattaa tgcagcaatt cggcgtcagc 3146701 cggcatacca tccgcaaagc gatcggagac ctcgtatcac aaggtctgct gtacagcgtg 3146761 caaggcggag gcacctttgt cgcttcacgc tctgctaagt cagcgctgca ttccaataaa 3146821 acgatcggtg ttttgacaac ttacatatca gactatattt tcccgagcat catcagagga 3146881 atcgagtcct atttaagcga gcaggggtat tctatgcttt tgacaagcac aaacaacaac 3146941 ccggacaatg aaagaagagg cttagaaaac ctgctgtccc agcatattga cggactcatc 3147001 gtagaaccga caaaaagcgc ccttcaaacc ccaaacatcg gctattatct gaacttggag 3147061 aaaaacggca ttccttttgc gatgattaac gcgtcatatg ccgagcttgc cgcgccaagt 3147121 tttaccttgg atgatgtgaa aggcgggatg atggcggcgg agcatttgct ttctctcggc 3147181 cacacgcata tgatgggtat ttttaaagct gatgacacac aaggcgtgaa acggatgaac 3147241 ggatttatac aggcgcaccg ggagcgtgag ttgtttcctt ctccggatat gatcgtgaca 3147301 tttacaacgg aagaaaaaga atcaaaactt ctggagaaag taaaagccac actggagaaa 3147361 aacagcaagc acatgccgac agccattctt tgttataacg atgaaattgc gctgaaggtg 3147421 attgatatgc tgagggagat ggatcttaaa gtgccggagg atatgtctat tgtcgggtac 3147481 gatgattcac atttcgccca aatctcagaa gtgaaactaa cctctgtcaa acatccgaaa 3147541 tcagtgcttg gaaaagcagc cgccaaatat gtcattgact gcttagagca taaaaagccg 3147601 aagcaagagg atgtcatatt tgagcctgag ttgatcattc gccagtccgc acgaaaactg 3147661 aatgaataaa aaaagcaatg tatgggtctc cccgctacat tgcttttttt atagctgtta 3147721 tctgtttttc caaacgtcag cgatgatttc aaacgaacgc attctgtctg cgtgttcaaa 3147781 ggtttctgag ttaaccataa tttcgtcagc ctgtgtcgtt ttgacgaaat cttcaagctt 3147841 cgccttcact tcttccggac ctccgacaat cgtggagctc agctgctcat tgaccatcgc 3147901 tttttcatac gggctccaga tttggtccat atcctcaaca ggcggtttaa gctggttagg 3147961 cgtaccgcgg acaagatcaa gaaacctttg ataatgggaa gtcgcaaggt gctgcgcttt 3148021 ctcgtttgta tctgccgcga taatggtgac accgaccatc gcatacggtt cgtcgagcac 3148081 gtctgacggc gtgaaggaat tgcggtacag ctccaaagcg ggaaccgtat tcgccggtga 3148141 gaaatgggcc gcgaacgcaa acggaagacc aagttcgcca gccagacggg cgctgaagcc 3148201 gcttgagccc agcagccaaa tcggcacatc tatgccctct ccgggaatgg cgcgaacttg 3148261 attgcgcaca tttcctgacg gtttaaaata attgcgcagt tcctctaatt gttctggaaa 3148321 atcctccccg ctgttgatgt ttctgcggag cgctctggct gtcaattggt ctgttcccgg 3148381 cgcacgtcca agccccagat caatccgccc gggatacagt gtttccagtg tgccgaattg 3148441 ttcagcaatg actaatgaag agtggttggg gagcataatg ccgccggaac cgacgcggat 3148501 tttcttcgtg cctccggcaa tatggccaat caaaactgcg gtggcagagc ttgcaacacc 3148561 ttctatatta tgatgttcag caagccagta acggtgatag ccccattcct ctgcccggcg 3148621 cgccaagtcc atgctgtttc ggaatgattc tgcaatcgtt cctccctgaa caaccggaga 3148681 taaattcaag acagaaagca aggtatcttt gcgttggttg ttagacatat tgttctcctt 3148741 tgcaaatgtg ttatcagtaa acagcccaaa gctgtcaggt catgattgaa agaacttcta 3148801 tcacaccata acacaactgc attcaggaat aaaagaattt gattcgatga aattcgaaca 3148861 atataaaacg aacggtttgg aacattattc tgctccaaac aactccttag ccatctcaat 3148921 aaagagctta gccgccagag aagcctcctt tagcgacgga acagcaagct gcacatcacg 3148981 gtatacctgc gggtccaatt ccctggtcac cacatgctct ggcagcggca tccccgacat 3149041 ggacatttct gataaaatgg ccaggcccag gccttctctg atcatactga tcgaggtgtt 3149101 gatgttatag accgtgaaag ctgggtgcag cgtagcaccc gcctgcctga acatatcgat 3149161 aaatggtgat tcatagccgc cgtcacagac gatcatcggt tcatggtcaa gatctttcag 3149221 cgtaatggct gaatgactgg caagcgggtg atcgtccctg agcacgacag ccattttgtc 3149281 ttttttcaaa tgaatgtact ccatctcctc tgttggatac agaagaatcc caacatctat 3149341 catccgcgta tgaagccact ccttgacttc atttacagtt ccctcgtgca gcacgagctc 3149401 aagtttcgga tatttttgtt taaattcact gatcagcttc ggcataaaat aagccgaggc 3149461 agttgagaat gtgccgatat ggatcgttcc cagttcaagc cctttttccg ctgctgctac 3149521 ctgctcaact ttttcaatgc cttttaagac ttctctgatg tgtactaaga tctgttttcc 3149581 cgtatccgtc agcatcaggc cattgcggcg gtcacgaatg atcagcttta catcaagctc 3149641 agcttcgatc gcagaaatcg catggctgac agccggctgt gtcatgttca gcgcctgacc 3149701 cgcttttgta aagcttcccg tttcagctat tttcacaaaa acctttaatt gagtaatggt 3149761 cataacaatt tacttatgct ccttataaaa aagattcatt ttatttatct tatgttctac 3149821 cgtatcatat gatggaaaag ttctacaagg agtgaatgaa caatgaagca gctcccaaaa 3149881 acgcggacag ctctcctgct cgcatttctc gtcatcatgt ggggcgtcaa ttggccgctg 3149941 tccaaagccg cgctcgccta ttctccgcca ttattgttcg cgggcatccg aacgctgatc 3150001 ggcgggcttt tattagtcat agtcgcactg ccgcgtattc ataaattacg cttaaaagaa 3150061 acgtggccga tttatcttgt ttctgctctt ttaaatatta cattattcta cggcctgcaa 3150121 acgatcgggc tgaattatct tccggccggc ctgttttctg caatcgtctt cttccagcct 3150181 gttctgatgg gtgtattttc ttggctgtgg ctcggcgaat ccatgtttgt aatgaaagtg 3150241 attggcctca tcctcggttt tgcgggagta gccgtcatta gtgctgcggg ctttggcggg 3150301 catatttctg tcattggggt tctgctggct ctcggctccg cagtcagctg ggcgctcggg 3150361 acagtatata tgaaaaaaac aggcagccgc gtcgattcca tctggatggt cgctctgcag 3150421 ctgacgatcg gaagcgtgtt tctgcttatc tccggctttt ggacagaaag cttttcggcg 3150481 atccaatgga cagctccgtt tattacgagc ctgctgttca tctccgtatt cgttatcgca 3150541 ctcggctggc ttgtcttttt tacgcttgtc ggttcaggag aagcaagcaa ggtcgcatct 3150601 tatacttttt tgattccgct catatcaatc gtggccagct ccattttcct gcatgaaccg 3150661 ctcaccctta gcctcttggc agggctgctg ctgattgtca cgagcatctg tctcgtgaat 3150721 acaaaatcaa aagcgcagaa agctgcggcg attggtataa acgagaaagc tgcacaataa 3150781 taaaaaccct cttgccggat gcggcaagag ggtttcttat ttactgatgc ttgcgtcctt 3150841 tgaccaaata tgcaactgta atcaaaaggt agatcgccgc agtaatgccg gtaatgacaa 3150901 ttgatgttgt catgatgacc ccgatcagaa tggcgagtaa tgccacaatc gcaaaccatg 3150961 tcgtgtacgg gaaccatttt acataatagg ccggtgtttc cgtttgctgt tttctcgatt 3151021 ttaaatgagc gaatccgatg atcagccaaa tgaataaaac ggtatatccc aatgatccca 3151081 ttaaataatt aaatgtttgg cttcctgcga acagagaaat caatacgcca atatagagag 3151141 aagaagtgca catcagaatc gcaaacatcg gtacgttttt cgatgaaagc ttcgagaaga 3151201 cctttggaag ccttccgtca cttgcctgtg tatacaaaat gcgtgatgat ccgtataaac 3151261 ctgaattcat agaagaaatg atcgccagca ggatgactgc attcatgata tgatccgcgc 3151321 ccggaatgcc taccatttta aagaccatca cgaaaggact ttccggaacg gaattgactt 3151381 ggttccatgg aatcaggctg acgatgatga aaaacggcag caggtaaaac gcgacaatcc 3151441 gtgtcagtgt gctgcggaca gctttcggga caaccttttc cggatttttt gtctctgcaa 3151501 gcgttacacc gataatttct gtaccgccgt aagagtagat gacgacaagc atcgccgtga 3151561 tcagccctgt gccgccgtgc gggaaaaatc cgccgtggtc tgtcaggttg gaaaatccgg 3151621 atgctgtatg atcaccgaat gatacaaata agagcagcaa tcccagaata ataaagataa 3151681 taataacggt aatcttgatc attgccagcc aatattcagt ttcggcgaag attttaacag 3151741 aaagcaagtt tacaatcgtg acgataagag aaattcctaa tgccaacacc cagatcgggc 3151801 agcccggcag ccaatattga atgaaaatcg cagctacaac agcttcagcc gcaatgttaa 3151861 gcacccacat tttccagtag atccagtcca aaaagtaagc agcgtaattt cccaatacct 3151921 gctggacaag atcacggaag gttctggcgt tacggtttcg aacagccatt tccgccagcc 3151981 cctgcataat aaacagcaaa ataatcccgc cgagcaggta tgcgataatg acagatggcc 3152041 ctgccacatc gatcgctgag ctgctcccct taaataaacc tgcgccgatt gctccgccca 3152101 gcgccatcat cataatatgg cgggacgtca tcgtgcgttt taacgtttga ttgtcgtttt 3152161 tcatcctctt ctacctctcc ttctcgtttt caaaaacaaa aaagcccgcc gtctcctacc 3152221 taatctaata gataaagaga cgacgagcct tcggctgacc gcggtaccac tcttgttgat 3152281 tcttcatgaa gaatcctgct tttgacctgt aacgaaggtt agccgttaaa acatagggaa 3152341 tattcaatct attccgttcc gtcttaccac tcccgggcga gttcaaagaa gaatcaggct 3152401 gcgtcgcacc accccgcagc tctctgttct gatcactttc ttttactgct cccaatctat 3152461 gtgttttagt tttctgaaaa actcaaattt tatgatctga atatattaac ataatatacg 3152521 tgcttctctt ttaactgtca ataacttcag agaaaaaaga aactgttatt ttgtcccttt 3152581 tcgaatggct ttccaaaagg attctgactc gtttcctaat gcgtaaactg aaacacctgc 3152641 tattttatat tgctttgcca gatggctttt cgtttgaacg gttttttcgt tttcatacca 3152701 cacgacatgt ttatgcttct ttttgtcaac ataagaaaac gtcatcgagc ctgatttttt 3152761 gttgaatgcc ggctttgctt tttgtttttt gatgagggat ttgagctcat tccattccct 3152821 tattgtgctg gtacttccgt cttttacatc ccagtcatag ccgtacgcag ggattcccat 3152881 gatgacttta ttggctttga tctttttgac tgaaaactgc agagagcttt tgatccagtt 3152941 tgtgcttgcc actgaccccg gctcacccca aatgccgtgt tcatcgtagg tcatgacttg 3153001 tacgaagtcg gcatatttgc cgattttcgc ataatcatac ggccagctcc agtcatcatt 3153061 tttatcatcg gcgcttttgg ccggaacgga taccattgtt ttaatatgtt tcttattcaa 3153121 agcctgtgag acatattgaa tgaagttcga gtatgcagcg cggtcttctg gatttactgc 3153181 ttcaaaatcg atattgattc cgtaatatga gtgctttttg gccagtgtaa ttaactgatc 3153241 tgtgaatcgt tttttcgctg ttttattgct catgacccga ctcgctaaat ctccgtcaaa 3153301 atcataaatg gcatcattat agtttgaaat gacagcccat gtcttgattt ttttcttttt 3153361 cgcatatgtc agctgcttag ttggggcatc gccaatgatt tgtccgtttt tttcaaacgc 3153421 aaatgtatcg gttgcgatgg cattcatgta tgtatgatat ttcgtaagag aattgtatga 3153481 agccgtatcc ccagtcgtgt agcctactgt cataccggct gccttcgctt ctccttttgt 3153541 atacataaac agaacaatcg caatcgccag tgaaaccgct atgatcagcc attttttcat 3153601 cgcatttcct cctgtatcaa gtcatactct tctcatcggc caaaaaattg gaagttgaag 3153661 ttttttcaag caaaaagccc ggcatatgcc tgccgggctt cctgagttca gcggtcagag 3153721 acgagaatat atgctgcctt tactggtcca tgcaccccca caactaaatc catttcaatg 3153781 tcggctgagt tactcggtcc ggtaatgtag ttgatacatg aaggaacagt gacaccgttc 3153841 gcaatgtttt ggcggatgat atcactggct tgtgtcattc tcggtacaat gcttgatttc 3153901 ggcacgatcg caatataagt cgttggcaaa aggctgacag agcggccgat gtcttttgag 3153961 gagaagagga caaccgtccc cgactcagcc aatgtaattt cgctgaatgt aatccctaca 3154021 ttggcttgct ccgctttttt aatattttcc tcgcctttgt cagcatccca ctcccagacc 3154081 ggcgttcctt cactcggcca gtccttggtg agcaggcttt tcagtccgta ttcttcaaag 3154141 cgggggtcct tcggaatgat gacagggcct ccagaaaagc ggctgacttg ctcgcgcagg 3154201 gcatcgtaaa ggccggttga atccgtttca atcagctctg tatggatttt gacacaatgg 3154261 tttttgagca ctgtgactaa gtcatccgct gaataacctt caagtgtttt atattgcggc 3154321 tgatgcgccc attcagggac tgccacgcct cctgttcttc gttcacggcc caggctggat 3154381 gcgattcggt ttaaaaagct ctcttgattc tgaatggttc ccttcgtcat cactgctcct 3154441 ccttcgtgcg ttcacttgtt tctctgtccg caaaccagtc tctgaatctc gatttatgcg 3154501 gtgccgggaa gtcgcgaatc tgggtccaat ttttaagcgg gccgggccct ttcgaaattt 3154561 tttcgtcctc tgtaaaaggc gtcatggcgg ccggcgccca ttttgagccc attttgtaaa 3154621 gcgataagga ggatgcgcca agtccgaatg ctttcattgc aagcttttca ctgatcggcg 3154681 ccctgccttc tttttcgacg atattctgac gatgcttgag tagcagctca tgaagcggga 3154741 ttttgaccgg gcaggcttct gaacaagcag cgcacagtga agatgcgtac ggcagctcct 3154801 tataatcgtc ataaccgccg agcaacggtg ataaaacagc tccgatcggc cccgagtaga 3154861 ttgagccgta tgaatgtccg ccgacatggc ggtacacagg acagacattg atacaggcgg 3154921 cacagcggat acattgcagc acagactgga attccgttcc aaggatattg gatcgtccat 3154981 tatcaacgat gacaagatgg aattcttccg gaccgtccac ttcaccttcc agcttcggac 3155041 ccgtcaaagc tgtaatatag cttgtcagcc gctgtccgac agcacttcta gtcagcatgc 3155101 tgactagcac ttcaaattca gaaaatgacg ggacaatccg ctccattccc atgacggtaa 3155161 tttgtgtttt cggcaaggtg ctcacaagcc gtccatttcc ttcattggtc acaaggctga 3155221 cggaacccgt gtcagcgatg gcgaagttac agccggtaat gccgatatcc gcttccagaa 3155281 actttttccg gagaatggcg cgcgcatgca tcaccagctc ttccggtttt tctgtatgtt 3155341 gatagtccag tctttcttta aacacatcgc gtatctgctc tttattttta tgaagagcgg 3155401 gcgctacgat atgtgacggc ggatcgtgat catcaatctg caaaatatac tcgccgagat 3155461 cggtttctac gacttcacag ccttccttct ccagcacctc attcagattg atttcctctg 3155521 tgaccattga tttagatttc acaattttct tcccgttctt cttttgaatg acatcccgaa 3155581 tataggaaga cgcctcttcc gctgttttcg cgaaatagac atgtccgcct cttttcgcca 3155641 cattttcggc aagctgtccg agatagaaat caaggttttc aaggacatgc tgcctgattt 3155701 cctctgataa tgagcgccac tcctcccagt ttcccagttc ttctgctgcc tctaggcgcc 3155761 gcgtccgcag acgctcctgt gcacctgaaa cagcgcctct cataaattca ttatcaatcc 3155821 cctgtgatac ccgctcttta aaagcgtcag taccgatttt catcgccatg atcctttccc 3155881 cctctgaatc cagttttatc tgctgttgag cacttcggcg atgtgcatca ctttgacatt 3155941 cttatctttt cggccaagcc gtcccccgat attcatcaaa cagccgcagt cagcaccgat 3156001 cagcacctct gctcccgttt cctccacaca ttcgactttt tcatcgacca tctgctcaga 3156061 aatctgcgcc atcttgactg agaacgttcc tccgaatccg cagcagttat gtttgcccgg 3156121 aagctctgta aactgcaggc ccttcacatg gctcaacagc ttcatcggct ccttccgaac 3156181 acccagcagc ctagtcatat ggcacgacgt atgtaaggtc gcttttgtat gaagggtcgc 3156241 gccgacatcc tctaccccaa ggacgttcac aataaaatct gtcagttcat acgttttatc 3156301 cgccagcttt ttcgctttat cggcccattt cggatcatcc tgaaacaggt gcggatactc 3156361 ccggaacatc gttgtgcagg aacccgaagg actgacaaca tattcggaat cctgaaacgt 3156421 ttcgatcatc cgtttcattg cttttttggc gtcatgtaca tagccgctgt tgtaagccgg 3156481 ctgtccgcag caaatctgcc cttctggaaa atcaacctcg cacccaagcc gctccagcag 3156541 ctcaaccgtt gcttttccga catttgtttg aaacatatca acaagacaag tgacaaaaag 3156601 tgagactttc atgatgaacc cctctctcat ccccaatata tgatcaggtc atctgatgac 3156661 ctgagttaaa ataactatat gaatatcgta cactattctg acaatggaag gaaagagttt 3156721 tctagggata ttttcatttg tggcatatca aaaacactcc cgatctccca ggagtgcagt 3156781 atatggttag atccagccct tttcctcagc gatgctggcg gcttctgtcc gatttttcgc 3156841 attaagcttt tggatgattt ctgagatata gtttcgaact gtgccttgag ataaatagag 3156901 ctccagcgta atgtcttttg ttgtcttgcc taaagccgca agcctcagaa tttcttgctc 3156961 tctaacggtt agcggatttt cgtctcgcat catattaaac gtcagctcag ggctgaagac 3157021 acgttttccc tttacacatt ttcgaatggc atcggccaga tcgtcaattt caccgtcttt 3157081 cagcagatag ccatgtgcac cggcctttac ggcgcgttca aaatatccgg ggcgggcaaa 3157141 ggtggttaaa ataatgacct tgctgacgca gccttttttc attaattcct ctgccacatt 3157201 cagcccgctt cgaaccggca tttcaatgtc cataatgcat acatccggct ccagcttcaa 3157261 aatagcatgt agcgcctctt ccccgtttaa tgcttgtccg atgactgtca tatcctcttc 3157321 taaatcaagc aaagatccca aagcgcctaa aagcattcgc tggtcctcag caataaacag 3157381 acgaatcatt cttttcgtcc tccaatcatt ctgctttttt aataagcgga atcgtcagtg 3157441 ccacaaccgt tccgttatgg tctgaaaccg ttaatccccc ttcaatgagc atgagccgtt 3157501 cttccattcc ccacaggcca ttcccaaaca ttttctcctt cggcgctccc tttccgtcat 3157561 cccgtattac gatcctcatt ttgtcagcaa attgagaaat ggtgatggca cagtgggttg 3157621 ctttgctgtg cttgataatg ttagtcacgg cttcccgcat acacatactg ataatatttt 3157681 gagtgacggg agatatcact gaaaagtcgt cggctccttc gtattgaaag gtaatgttcc 3157741 ccgctcttaa tatgtgctga atgtttacga gctcctctgt tatcgtgacc gttctcatat 3157801 cagaaaccag ctctcgaact tgcttgagtg cggagcgtga actggtttcc atttcttttg 3157861 cctcaagctt ggtccgttct ggatcagatg cagccagccg ctgaatgagc tggcttttta 3157921 atgtaagcag cgacagggtg tggccaagag tatcgtgaag atcacgggcg attcgaacac 3157981 gttcctccct tttagagagt tcttttatct gttcgttggc ttgtgcaagc ttagcttcaa 3158041 gctcaatcct ccgaaacata gaacgaattc cgaatggaga aatgagcata atgacgagaa 3158101 acgggagaac agaaaaaagc tcccgaagcg agaccgaatt cgcgataaat tggtataggc 3158161 atggaaaaag cagtataaag attaaagcgc agaacgcacg gttaaaattc gttttctctt 3158221 tgtaataacc aacaaagttt gccggaaaaa aacctaagta tatataggtg atattgtaaa 3158281 acacactata catcaaaata accgccattt gcacgataag ccaatatgta aacgaagctt 3158341 tgcccacgct gcagaataac tggcgatatg ccgctacaaa aaggagcagc ataccatatc 3158401 cgatcccctg tttgacccct gattctttta ataaagagag gaacggcata atcgtataca 3158461 ccagaaagat ataagggaaa aacccgaatt ccttcgggaa aatagatatt gcctttttca 3158521 tgtattacac cgcttcttgt tttcttctta tatatttaga tagtagcatg aagagcatca 3158581 tataagcgat taatatcaga atatttttcc aagtcggact cccaccccgg acaagttccc 3158641 acgctccgct cccgaaatga taagacggaa gccactggcc aatgctctgc atcatgtcag 3158701 gcatgacctc aaacggcatc cacatccctc cgcctaaagc cagcagcata taaagcacat 3158761 tactgattcc ggccgctgtt tctacttttc tcatgaggcc gattagtgtg cctaatgcta 3158821 aaaaaggcaa tgcgccaaac aaaatccaca gtccgctcat catccattca aacggtgaca 3158881 aggcaatatc attgatgatt gcgccgaaca gaaatatgac ggtaattgat aaaacgtgaa 3158941 tgacactttg gccgatcatc tgagctgata aatagatatg atccggaaga ggcgtaaggc 3159001 ggataaaggc ggcccagcct tgtgaccgtt cttgtaccat tcggatgcca agcgtcatga 3159061 tagaggaacc catcacgctg aagactgtca tcgacatcag gtaatgggct tcccatgcac 3159121 gttgatcagg gacgttggta ttcactacat ttgtaaagaa ataataaaag gcaatcggca 3159181 tgatcagaga ccaaagcaca aagtacttgt tcctaagcac ccttttcatt tcagcgatgc 3159241 tttgcttttg cagcacgttc actcacatcg cctccctgtt gccgtcagcc agctggcgaa 3159301 atgcctcatc gagcgttgct tgctcaattc gaatatcccg tgcatgtatg ttttcttgaa 3159361 agatcagcgc caacactttg tctgtatttg atgtctggat gatggttctc tcatgctcgt 3159421 ggatcactct ctcgacttcc gggtgacaag acagcctttc caatgattca cttgaatgaa 3159481 gcgtaaagga aacagactgt ttttgaattc ttgagcggat ttgcattggt gagccgtctg 3159541 caacaagctg tccttcagta aaaaatagga ttcgctgtgc ggcatcatct gcttcctgta 3159601 aataatgagt tgaaaaaata atcgtttttc cttggtccga cagtccgtga atggtctgcc 3159661 agaatcggtg tcttgatgaa gtgtccatgc cgactgtcgg ttcatcaagt ataagcagct 3159721 ccgggttccc ggcaagagcc aaagcaaagc tcaaacggcg tttttgtccg ccggataatt 3159781 tttctgctct tgttttcaaa tcttctttgg tgagtgctgt taacgaaacg agttctttca 3159841 tggacaatgg attcggataa tagctccgga agagttcaag gatttcatcc accttaaggc 3159901 ccggcatgac acttacttcc tgaagcatta cacctatttt ttcacgaacc tgttgatcat 3159961 cgggaacccg gttaaatagt ttgatttctc cctcactcgg tttcagcaat cctaatatca 3160021 tcgagacgac ggtcgtcttc cctgccccat ttggcccgag aatggctgca atttctcctt 3160081 tttcaatact gaagctgatg ttgtttacag cggtttttcg ctggaaatgt tttgtcacgt 3160141 tgcttactgt tactgcttct ttcatcacat gagcacctcc tgatcgttta cattgattgt 3160201 aaaatgacgg agaagacgat gttagtatgg ggtgtcatga tgatggagtg acaaatgtca 3160261 tttttttctc accccggtgt ctaggcaatc ctcctcctgc atcttccaat tcatccatct 3160321 tttctatctc ccatgtcctc tttcttttaa actgctgtga cattcataga aagatacact 3160381 cttcaaacca tccgagtgtt atgatagaaa tattgaactt tatattactt tccggctgaa 3160441 aggagccaat catgaacgaa gcgattttgt ctagaaatca tgtgaaggtg aaaggcagcg 3160501 gcaaagcatc tatcatgttc gcacctggtt ttggatgcga tcaaagcgtg tggaatgccg 3160561 tggcacctgc ctttgaagaa gatcatcggg tgattttatt tgattacgtc ggttcgggac 3160621 attcagattt gcgcgcatat gacctgaatc gttaccagac acttgacggc tatgcccagg 3160681 atgttcttga tgtttgtgaa gctttagatc tgaaggaaac cgtgtttgtg ggtcactccg 3160741 tcggggcctt gattgggatg cttgcatcca tccgccgccc ggagcttttt tcccatctgg 3160801 tgatggtggg gccttctcct tgctatttga atgatccgcc tgagtattac ggaggatttg 3160861 aagaggagca gctccttggc ttgctggaga tgatggagaa aaattatatc ggctgggcga 3160921 ctgtatttgc ggcaaccgtt ctgaatcagc cagatcggcc tgaaattaag gaagagcttg 3160981 aaagccgttt ttgttctact gatcctgtca ttgcccgcca attcgcgaaa gcggcgtttt 3161041 tttctgatca ccgagaggat ctttcgaagg taacggttcc ctctcttatt ctccaatgtg 3161101 cagatgatat catcgcacct gcaacagtag gtaagtatat gcatcagcat ctgccttata 3161161 gcagtctgaa acaaatggag gctcgcggac attgccctca tatgagccat ccagatgaga 3161221 cgatacagct gatcggcgat tatttaaaag cacacgtgtg atataggaac gaaagggata 3161281 gaggtgaccc tcttagatgg acaaacaatt gaatgatgca ccatgcggtt tcctcgcttt 3161341 gtcagaagag gggtcgatca tagctgccaa ccgcaccctt atcaagattc tggattatga 3161401 accggagcag gttatcggcc agcacatgaa tatgatgttg accattcccg cgcagctttt 3161461 ctgccagctt tatttttttc cgcttttgaa attggagcat cacatcgaag aaatatacat 3161521 ttccctgaaa gcaagagatg gagaagaaat tcccgtcctt atcaatgcta ttgcgagaca 3161581 cgatagcggg gcttctgtct ttgattgtgt tctgattcca atgcgaaagc gaaatgaata 3161641 tgaaaatgag ctgctgatag ccagaaatga ggctcaggaa gctttgcttg ccaaacagaa 3161701 agccaatgcg gagttagaaa ttgccttgga aacgctgaaa gcaaaacaag aagaacttct 3161761 tgagatcaat aaacaaaatc aacaatttaa attaaacacc aaaagagagc ttgaactcgc 3161821 cagaaagatc cagaaaaact cgttgactga accgattgta aacgatcagg ttcagattga 3161881 ctcttattac aacgcatcga gtgaattgtc aggtgatctt tacggatatt atcaaatcga 3161941 tgaacaccgt tacggcatta ttatccttga tgtgatgggg cacggaattt catctgcatt 3162001 gattacgatg tctcttcatc ctttgttcca gcgccagatc acgcaaggtc tcagccccgt 3162061 taaagttatg aaggaattgg accggcacct tcacagcttg tttcaaaatg atgaggaagc 3162121 aagacattat tgcactgcta tttatctcga gattgatata gcacggcaaa gaattgatta 3162181 tgtcaacgca gggcatccgc cggcactttg gcaggacgat agcggaactc aacatctgct 3162241 tcacgcgacc tcgcctccga tcgggatgtt tgaagactta gagtttcagt caagcagcct 3162301 ttcatacacg gaggacggaa gattgcttct gtatacggat ggcgtgatgg atcctacggc 3162361 ttcatgttat ttatttgatt tactaaagga tcatcctgat tcgccaatcg ctgacctgaa 3162421 ggagaaaatc cttacatcac tgcagcatca aaaggaagct catcataaga gtgatgacga 3162481 atgttttata ttagttgatg taaaataaaa tgatccatga gacataacaa tgatttgtta 3162541 catctcatgg atttttttgt ttcagcgttt ctttggaata tgtcctgact ccgcatattg 3162601 aaacacctgc aaggaaggca gcgggtgtcc attaaaatca aataaagctt gattatctac 3162661 agcacttccc ccataccact tcccggcgtc ttcagggtcg tattcagcag catagctgga 3162721 cgcccaccct gacccgtatg tttcccataa cactttgttt ttctctatct gtgtcttcgg 3162781 cccgactgga atccacgccg gctcccagta gaaaacacca agtcctgctt tgcccgtatt 3162841 cgccactgcc tccattacat ctcttactgc agttgcctgg ccttgaacag aaattggata 3162901 tggcaacgtc tgcccgcttt ttggtgctgt atttccatgc ccatcgccat cctcagcggt 3162961 ataggtgtac gatgtctccg ccaccatgac ttttttgccg tacgtattgg caacagcctt 3163021 cagcacggag gtcaaatttt gtaatgtgcc atgccagaaa ggataatagg agctagcaaa 3163081 cacatcataa tccactttgt ttttgctgag tgtttctgca ataaatgaat accttccagc 3163141 cgtttcagga ttggtaaaat gcagggcgac caaaatattt gaatttgtct ccctgaccgc 3163201 tcggcttcct tcattaaata attggcacat cttcgtccaa tcagtctcac cggcaaatcc 3163261 tcctgttgtt tcatttccga cctgaaccat gccgatgtca acgccttcct tgatcatctt 3163321 ttgcaggctt tgtttcgtat actcatagag ctttgctttt tttgcttcaa agctgagatt 3163381 cgcccaggct ttgggcacct tttgtttcgc tggatcggcc cagaaatcag agtagtgaaa 3163441 gtcggccagc accttcattc cgttcgctgt cgctcttttt ccgatttcga tggctttttg 3163501 aacatcattg tttcccccgc catacccgtt gccatttgaa tcatacgggt gattccagat 3163561 gcggacgcga acatagttga ccccagcctg ttttaaagtt gtaaagatat cctggcgttt 3163621 tccgtttgta ttgtaaaagg tgacaccgct gttttccaaa gcaataacgc tggatacatc 3163681 tgcccctttg ataaaatcct tgttcatccc ctctactttt ttaacaaaaa gatcctctgc 3163741 ccgaagctct gacacgtgct tctccttctc aatggcagcg gcatatcctg ttgaactaca 3163801 tgcactccac acgatggcag ccgcaaagaa cattttcact ttgcttttca tgatttcatc 3163861 cccccaagac ttagcaagcg ttttcattct atagaaaaaa gaatccgccc atatcgagcg 3163921 gagcatcagc ctaatgtgtg tttacgacaa ttctcacttc atacttttcc atcgtcaggt 3163981 cgcctgacaa tatgtctcct gtcattatgt ccttcacact ctgatcaaac gtgaccagct 3164041 gtttttcttc cgtgaaattc atgacaaaaa tataatcatt gtcctgatcc tgcctcgctt 3164101 gtacggagac gccttttccg tgccgaaccg gaaaaactgg agagagagac aggtctgtga 3164161 tcagaccctc atagaaatca cgctgaaatt gatcctccaa acgcgcgccg ataaaatacg 3164221 ccttgccctg ctgatactca tggcttgtga ccgctggcgt gcgcgcataa aaatcttctt 3164281 gatacaccgc ttccactgaa gctgtcttta catcaatcac ggttgcataa tccttcattt 3164341 catatatttg gctgcggtag ctgacagcgt ttcgatcctt cggatacagg gtgtccgttt 3164401 caagaggctc aactccaaat atagcttgaa gatccggatg ccatccgcct gtgtatgtta 3164461 agtcatgctc attcacaacc ccgctgatat acgtcatgac taaggtgccg ccgtcagccg 3164521 taaacgcttt taaacgggaa acggtgtcct cgctgattaa atacagcatc gggacgatca 3164581 gcagtttata tggtgaaaag tcttgttctt tcgtgatgac gtcgacaggg atatcgtgtt 3164641 cccagaatgt gcggtaatgc tgctgaagcg tttgcggata acgttttgtc gccttcgcaa 3164701 acccctgagc atcctcgagc gcccaatgat tttcccagtc atataaaatc gcggtttgag 3164761 ccggcctctt cgttccgaca acttcggaca gccgttccaa tgtctcgcct accttggcca 3164821 cttcttgaaa gacgcggttc ttcgggctat tgtcatgatc cacaaccgct ccgtgtaatt 3164881 tttctgatga cccccgtgat ttgcggtatt ggaaatagag aacgctgtcc gagccgtggg 3164941 caatcatttg catggatgac agcagattca tgcccgggcg ctttgccttg ttgacgttat 3165001 gccaattgac cgcgcttggc gtacactcca ttaataagaa gggctgctgc ttcaagcttc 3165061 ggtacagatc attgataaag ccgaccttca tcgccaaatc agctgtgctt tcccagtcat 3165121 tgtgccagac aggataagcg tcccagctga tggcatcgac atgctttgca aatttgctgt 3165181 agtcgaggcc ctgatacggg atcaaatccg gtgtgtcagc cataaaattc gttgtgatag 3165241 ggatatcagg cgtcaattct ttcagcggaa tgatttcatt ttcataaaac gaaatcgttt 3165301 gatcggtgac gaaccggcgc caatctaaat tcaggccatg caagccattt tcaccgatcg 3165361 gcgaagggct ttcaatttgt gaccagtcat tgaacgtatg gctccaaaaa ggggtccacc 3165421 acgcatggtt caatgtcttg aggctgttgt catatttcga tttcagccac tcccggaaag 3165481 catgctggca taaatcacag tggcaatctc ccccgtattc gtttgaaatg tgccacatta 3165541 acagcgccgg gtgatgtccg tatcgttctg ctaataagcg gttgatgtgc cgtgtttttt 3165601 ctcggtagac tttagatgtg aggcagtggt tgtgccttcc gccgtgcagc tgtttgacgc 3165661 gggaggcatt gacgcgcaaa acttccggat aggtttgcga cagccaggcc ggacgggctc 3165721 cgctcggcgt tgctaatatg acccggccgc ctatactgtg aatccgctca aaaatatcat 3165781 ccagccattc aaattgatat acgccctcct ccggctcaag tgcgctccat gcaaaaatgc 3165841 cgacagaaaa cgtattcgta tgagaaagct tcatcagttt gatatcgtca gctaaaatat 3165901 cgggccgatc cagccactga tcggggttgt agtctccccc atggagcata aattttgctt 3165961 ttgttacgtg cgttttttca agctttgaca tcacattctc ctccttgttc tcttagccct 3166021 tcgttccgcc tgcggttaat ccggacacaa aattcttttg cagcataata aagatgacgg 3166081 caaccggtat gctgataagc agggctccgg ccgcaaatgt cgtatagctg gcccccatga 3166141 catcattcac taaattgaat agaccgacgg gcaatgtata tgattcaggc gttctcaata 3166201 tggttgagga cagcacaaaa tctccgagcg gaccggtaaa gccgttcatg gccacgactg 3166261 ccgccatcgg ttttgataat ggcagaatga tctggaagaa gattctggtg ctgctggctc 3166321 cgtcaatctt ggcgctttcg tctaaatcca tcggaatgga atccatgtac cctttcatca 3166381 aatacgtatt catcgggatc aggccgccga tataaagcaa gattagcagc cagtggctat 3166441 tgatcattcc caagatttgc gccagcacaa acaaggcaat taaagctgaa aactgaggaa 3166501 tcatctgcag caataaaaag agcgttaaag cgtatttcct ccctttaaac cgaaagcgcg 3166561 aaaacgcata ggccgtaaac gtcacacaga gcaaagaccc tgccattgta aacaggctga 3166621 tcttcataga gttgacatac cactgcacat attgaaggct ttccttgccc gcaaataatt 3166681 ccttgtaatg atcgaatgtc ggatgcttcg gaatgatgga tgtactgatt aagctgttgc 3166741 cgggattaaa gcttgcgcct gccgtccaaa ggagaggata aacaatgatg accgccataa 3166801 aggctagcaa caagtaagag aaaaggagac ggatatatct tctgactttc atatctgcca 3166861 gcatacctta tgcctcctct ttaaaagact ttgtctgtct gaactgccac aatgcgatgg 3166921 agataacaaa tacagataat aaaatggtta aagccgcagc aagtgaatat tggctggact 3166981 gcattgtcaa tttataaatc catgaaacga ggatatctgt cccgccggct gttgatccgg 3167041 ttacagccgg acctccgcca ttgaatagat agataatatt aaagttatta aagttaaacg 3167101 taaactgagt aatgataatc ggagccattg caatgaacac catcggaagc gtgatgtatc 3167161 tcagctttga aaagacagaa gcgccatcaa tcgtagctgc ttcatacaga tcgtccggga 3167221 tggattgcaa tacgcctgtt gagacgagaa agatgtacgg aaatccgagc cagccctgca 3167281 tgagaatcaa tgcaagcctc gaccaattgg catctgtcat ccacggaagc ggatctatcc 3167341 cgaagaaagc caagatgtcg tgattcatcg caccgaagct atcattaaac agtcccgcaa 3167401 aaattaaaat cgtcacaaaa ccgggaacgg cccatggcaa aatcagaatc gtccgaaaaa 3167461 aacgtttaaa ccgaaggtct ttctggttaa caatgatcgc gagaaaaatc cccaaggtga 3167521 cttgcagtgt ggatgcagca agtgtccaaa ccaccgtcca agccagtaca tcaaaaaaag 3167581 tcgacctcca aatatcaact gtgaaaatat ttgcgaacgt ttgaaaaccg acccaatcaa 3167641 ttaattttgc aggaggagaa tgatacaaat catagtttgt aaacgctaat gcaaagctga 3167701 ataagatagg aaagatcacg gcgaaaatta aaataaacaa agatgggccg ctgacgacat 3167761 aaggatagcc ctcagaaatg atatgctggt attgttcctt taaggaactt aatggcttat 3167821 tttcatcacg ctgttttccg ctttggaacg catcgcgaag atttacataa tacaccgcaa 3167881 ggccaaagca ggtcacgatg acagcaataa tcccttccgc cagcagaaaa acggaattat 3167941 cccgcggcac ttctgttccc agtgtaaaga ttccccaaaa ccccatattg agcagatctc 3168001 caaagaccgc aaaaaacgat gcgcctaaga aaagaaagac aatacctttt atccattgct 3168061 tgttataaaa ttgcccgagt cccggaatga tagaaagcaa caaagcgact tgacgatgct 3168121 gcaccgtttt cacctctctt acaatacaaa tctagctttc tctttatttt ccgctgtgct 3168181 ttgccttaat ttgtcctttg gccgtttcag ctgcttgatc caatgcttgt ttcggatctg 3168241 ccttccctgt tgcaaccgtc tgtaatgctg aatcagccgg cgtccatatt tcattcattt 3168301 ccggaatatt tggtgttggc tctgagaaac gggattgttc agtaacagcc cgtgccgcct 3168361 cgcttttcat aatagccggg tcattggcta gggatttcac agcaggaact tctttcgttt 3168421 cttcatatcg tgttttagaa tttttttcat ttgccaggaa aacggctaat tcttgcgcca 3168481 gctcttcatt ctttgaaaat gcactgacgt tgtagctttt gacgccgata aaggagctca 3168541 tgtttttccc attttccagc ttcggcagtt tcgtaatgcc ataattgatt cctgcattcg 3168601 aaaaggcttc tacattccat ggaccagaaa taattgcggc ggcttttcct tctgtgaaca 3168661 gcgattccaa cacgttaatc ccttgttctc caataatgcc agccgggaac aggccatctt 3168721 tgtaaaactt ctgaatcagc gccgcacctt tgacagctcc ttcattattg attccaatgt 3168781 ctgacgggtt atagctccca tctttggcct ttccaaaaat gtatccgcca tatccgctca 3168841 tcacactttc tgcataataa atttgatcga atagggctaa aaagccaaat ttgctgccgt 3168901 cagcagtctt tttggaatag tcgtaccact cttccagcgt tttgggcaat tccttttctg 3168961 tgatgagatc tttgttgtaa aaaagcacag tcgtttcgac cgcttttggc agtccataaa 3169021 gcttttgatc taccatttga gactgaatgg aagcgtcagt ataaagtgat tgaacgtctt 3169081 ttttgacatg taattccttg agtaatcctt ccgtgacagc ggttccgatt tggtcccctg 3169141 gcattgttaa cacgtcaggg cctgtgccgg ccggtccatc cattcgcaaa tcttcaatct 3169201 gcttggcata cggtttttca acgactttga ccttcacatc atgctctttt tcaaatgcag 3169261 ccacagcgtc tttaatgccg ttgctctttt ctttatcctc ccatacaaca agctctgacc 3169321 cttttgaact cgatttggcg ctgctgcttt cctttgggcc gcaagccgcc aaggataaac 3169381 tgacagctgc gcagagcatg aatacggaac acttttttgc cattttcatt gattgtcacc 3169441 ctttcggtag gaatgaaagc gctttaaaga taatatagca tgcctgagaa aatgtgtaaa 3169501 caaactattt acttcataga gtaaattttt ttacctaaat aaaaaatgac ttagtgtcct 3169561 aagtcatcct taattcatac tcttcctgac gattaattct gcgcccacat ataatgtttt 3169621 taccgttctt ctcttgtcct gcacttgttc aagcagtaat tgaacagcgt ttttacataa 3169681 ttcatgtata tcaatatgaa acgtcgtcag aggaggcgag acatacttcg cgaagctgat 3169741 gttgttgata ctcacaatgc ttaccctgtt tggtatggca attccttttt cgttcagggc 3169801 ttgcagacag cccactgcaa tcgggtccgc tgcaatcata aaagcagtcg gaagctgatc 3169861 gcctaatgtg tcgatcgctg ctgacatcag gcggtagccg ttttctacag agaatccgcg 3169921 atgacagaaa atatagcgct cgtccagcat ggctttttcc ctcatatagg atctgaaggt 3169981 ttgttcacgg atgtccattt catcctgatt ggtattcgga tttttgtatg tgccgccgat 3170041 aaaaccgatg ctcttatgcc ccttctcagt caggatgttt accgtcttcc ttgtcatttg 3170101 tgccaaatcg ggccttaccg agtcaaaatg atcgggatca ggagttgaat cgatgaacac 3170161 gccgttttca gtgagatttc tgaggaaagc cagctcttca tctgaaaatg tgccgacggc 3170221 aataaaccct tccgtatgtt caggaatgct ctcgattcca tccgctattt tataagtggt 3170281 catatcgaca ttgaatgctt tcgccagttt ctctacttct aatctcatcg ttttaaaata 3170341 gacatcttct aattcttctt tatctgtcag ccaatataaa aacgcaatat gtttcaccag 3170401 cggccttact gtttttttgc ggtaattgag cttttccgcc gcttcataga ttttctcccg 3170461 tgtctcatca ggaacagaaa ggctttcatc gttatttaaa acgcgggaaa cggttgagat 3170521 tgaaaatccc gcttcctgcg cgatatcttt aattgtcgcc attgtatctg cctccattat 3170581 tcagctcgca ttgttttagt aaaatatttt actttctttt tcacaaatgt caagtgcaca 3170641 aagccctctg gctgccatgt aaaaagactg aaccatttgc ggctcagtct cagttgttcg 3170701 tatcattcgg aaccggcgga attgcccggg aaatgagttg gttattgcac attttcctcg 3170761 aaatatcccg aaagcacatc ttccacattc gtcaaatgcg ccagcatggc ggcttccgcc 3170821 tgtgcaccgt tcccggcagc cacagcattg taaatccgtt cgtgctcctc atacagccgc 3170881 tgaacggagg tcttcttgga aaacagccag attttcctcg tttccctcat tgtttccagc 3170941 agcaatgatg acacgtgatt catcaagtgt ttaagaagtt cattttgaga agcgtccgca 3171001 agcgcaagat gaaatgcaaa gtctgctttc tctcccagct ccccgtccgc ttcaatgctg 3171061 cccatttcct ttagtgcatc ctgaattctt tcgagatctg cttctgtcct tttttcagcc 3171121 gctagtgaag ccacgccgat ttcaagcagt tttctgacct cgagcagctg cttgacgtcc 3171181 tcttttttca tcagaagggc ggctgagagc ggctgagaaa tttgattgag ctcaaattcc 3171241 ttcagatacg tgccttctcc ctgtttcatt tcgacaagcc ccatcgcttt tagcgcagaa 3171301 agtgcttcgc gaaccgctga acggctgact tgaaagctct cagcaagcgc ctgaacagag 3171361 tccagtttat cccccggctt caattcgcca tttttgatca tatctaatag ggcatccgct 3171421 acttcttcat atattttttt gttttaatct gtttatattt caatgcaatt caccccgtaa 3171481 cttgtaggtc tggctgttta cgatctatta tactctgttt tgtgggccgc caaaagattt 3171541 tgactatttt gtcaaaaagt cttgtacttt gatttttttc aaaatataat gctaggtaac 3171601 tggtcttatt acccagtcat cagatgatca tatcatctat agaaaccgct tacatatggc 3171661 gccagtttat gtttcaagga ggggtttggg atgcaatgga cacaggcata tacgcctata 3171721 gggggaaatt tgctattatc agcgcttgcc gcacttgtac cgattatttt ctttttttgg 3171781 gcactcgcga ttaaacggat gaaggggtat acagcaggct tggccacatt ggggatcgcc 3171841 cttatcattg ctgtattggt ttatcgtatg ccggcggaaa aagcgctgat gtccgcgaca 3171901 caaggagccg tatacggatt gttgccgatc ggctggatca ttgtgacgtc tgtttttttg 3171961 tataaaatca ctgtgaaaac gggacagttt gatatcattc gcagctctgt tctctcgatt 3172021 actgatgacc gacggcttca agctctcttg atcgcttttt cattcggggc ttttttagaa 3172081 ggggcagcag gcttcggagc gccggtcgcc atttctgccg cgctgctggt cggtctcggc 3172141 tttaatcctc tttatgctgc ggggatctgt ttgatcgcca atacggcgcc ggttgccttt 3172201 ggggcaattg ggattccaat tacagccgta gaagggccga cagggattcc ggcgatggag 3172261 atttcgcaaa tggttgggcg gcagctgccg tttttatccg tatttattcc tctttattta 3172321 atcatcatca tgagcgggtt caggaaagcc ttggagatct ggccggcgat tctcgtatcc 3172381 ggtgtttcct ttgctgttgt tcaatatctc agttccaatt ttttagggcc tgagctgccc 3172441 gatgttttgt cagctcttgt ttcaatggct gcgcttgctg tgtttttgaa atggtggaag 3172501 ccgaaaacaa cattccggtt tgccggtgaa caagagtcgg ccgcctcaat tgaaacggcg 3172561 cgcacaaatc cggcggcgcc tgcatacaga ggcggacaga tttttaaggc ttggtcgcca 3172621 tttctgctgc tgacggcgat gatttccgta tggggcattc catctgtcaa atccgcgctg 3172681 accgggcatt atgaaggctc tgcggtgttc ttgaagtggc tgaatgctgt tggagaaaaa 3172741 ctgacttttt cccccggtgt gccttttttg aacaatcaga ttgtcaatgc tgacggtacg 3172801 ccgattgaag cggtttacaa gttggaggtg cttggttcgg ccggcaccgc gatattgatt 3172861 gccgcagtgc tgtcaaaatt catcacggcg atttcgtgga aagactgggg aaccgttttt 3172921 aaagaaacag tccaggaatt gaagcttccg attttgacca ttgcttctgt cgttggtttt 3172981 gcctatgtca ccaactcctc gggaatgagc acgacactcg ggatgacact cgcgctgaca 3173041 ggttcgatgt ttaccttctt ttcgcccgtt ctcggctggc tcggcgtctt cattaccggc 3173101 tcggatactt ctgccaacct gctgttcggc aacctgcaga aagtcaccgc attatcagtc 3173161 ggcatggacc ccgttctgtc tgtggccgcc aactcttcag gcggtgtcac aggaaaaatg 3173221 atttcaccgc agtcgatagc ggtggcgtgc gccgcggtag gactcgccgg aaaggagtca 3173281 gatcttttcc gctttaccat taaacacagt ctgtttttgc tgctgctcgt ctgtatcatc 3173341 acctttttgc agcatcacgt attcagctgg atgattcctt aaaaaaatcc tcccgtctag 3173401 ggaggatttt atttatatcg ctttctcgct gccgatgacg gaatattcat ttgatcgcga 3173461 tattttgcca cggtgcgtct cgagatttgg atgccgtgtt gttcatacag caaatcgaca 3173521 agcttttggt ctgaaagcgg ttttgttttg tcctcttgat tgatcaggtt ttccagatgc 3173581 gttttgactg cataattcga cgcatctcca tcacctgaag cctcggcttt tgctgagaaa 3173641 aagagtttca tctcaaacag cccgtaaggc gtttgtattg ttttcccttt aatggcccgg 3173701 ctcacagttg attcatgaag gcttagacag tctgccacct ctctgagagt cagcggcttc 3173761 attgcgcttc gccctttcag aaagaaatcc ttttggcgtg tgatcagttc attgataatt 3173821 ctcgtgattg tctgttttcg ctgccgcagc gcgcggctca gccagcgcca ctcctgatat 3173881 ttcgcagata aataggagac agtatcctga caggagccgg atgataaaag cgttctgtac 3173941 tgcggatgca gatcgatctc gggaaacgag cgggtattca gttccgctgc gatgtgccca 3174001 ttttttacgg tgataaaaat gtcaggctca atatacacat cttgctctgg ccgggcaaac 3174061 agaaggccag gtctaggatg aagagccgcg atatcatctg agatatcttg aatggtatga 3174121 agcggaattc ccgtctctac tgaaagcgtt ttccattttt tttgcgcaaa agcatcaaaa 3174181 tgagctgaaa ccagcatttc cgcttgttca tttctgttcg gcagccgctg taattgaaga 3174241 aggatgcatt cctgcaaaga tctcgcgccg attccagccg gttctaacga ctggagtttt 3174301 gccaaaacag cctccgcttc cttggccgat acagataatc gccgtgctgc ctcctctata 3174361 tcttcttcca agtacccgtt tgaatcaagc gaatgaatca gataattaaa aatctttttt 3174421 tcagtgtttg tcagattcat atcgagtgac tgctgtttta acgcatcctg caatgttttt 3174481 tgcggattac ttaattgaag gcccgcttcc tgtgcattca tcctgttttt gtttgtttta 3174541 tggtaagata gtggcggtgt gtctgtttcc tttcgttcaa taagagggtt ttccagtgag 3174601 agctcatcaa tgtactcggc gagttctgcc gaatgatagc caagcagcgt gatggcctgc 3174661 ctgagctcct gtgtcagttg aggctttaat acttgtactt gctgaagttt catatccatc 3174721 ttgctcactc ccctttcttc attgtacatg attgagatca caccgtatac atttatgaaa 3174781 aaggagctgc caaagaaatg tctgaacttt tttccgtccc ttattttatt gagaatttaa 3174841 aacagcatat tgaaatgaat cagtctgagg ataaaatcca cgcgatgaac agctactacc 3174901 gttccgtcgt ctcaacacta gtgcaggacc agctgacgaa aaacgcagtt gtcctgaaac 3174961 ggattcagca tttagatgaa gcatacaaca aagtcaaacg tggagaatca aaataaacct 3175021 tccgctcaca tgtgagcagg aaggttttcc ttctttgagg cgtgctggat gagacgggtg 3175081 cttggcacgc cttccatcca ggtatgaaag taattggcgt ttttcccgta ggaattatca 3175141 atgaccgtgt tttctttttg aagaagagaa gacaggatgt ggccgtgcag ccttgatgtt 3175201 tccaccgatt cgtaacggct gaaaaaccga atcgcttttt ggacgatata atccgagtat 3175261 ttttcccata tatacgcaat gggcaaaggg ttgcctgctt ttttattcaa gacgttcagc 3175321 gtttggagaa aagcaatcgt ccggcggtct gaagctgaca gcaccgtgcg ccagtcgtag 3175381 ctttccgctt ctgcgtgttc ctgaagcgcc tggtttgctt catgatctgt tcggataaat 3175441 ctcagctttt gattggacgg ctgctgcgtg ggaatgacgg gaaacagctg atgagccata 3175501 tcaggcagaa gctgaatgtg atttgttgta aaataggcct gtgccgtagc ataggaggct 3175561 ttttcccttg tcatgatgtg aaggttcgca tgcttagaaa atatctctgc cgtccgcttg 3175621 aggttgtctt tgttttgaaa ataaatcgat tgcggcagga tcacaatttt gtggttcgga 3175681 taggtttgga cgattttctc tctaaagcct tgataatacg gatacagatc cccgaagttt 3175741 ccgcctccct ggcagacgat gatgagattc ggatcaagct ttcgcccgat tgggaaattg 3175801 tctggattcc agcgttttct gacccgaatc ccgtgttctt taaagaaggc ttctgttcct 3175861 ttcataataa ataaatcccc tacattccca tatagaggat agtcagcata tataatctct 3175921 gattgtttcg gaatgacgtc gagcagcccg gacagtttct gtttcaggct gatcatcgaa 3175981 tgcttgctgt ccatttcttc acctcgacag tatggaataa gtgcagtagc acttcaatga 3176041 cccggccttg ctcatcttct gtcatattgg accccgatgg gagacagatt cctcgcttga 3176101 acaaatcttc gcatacgctt cctgtatctt catgagaata aaataaagcc ggatcgaaca 3176161 gcggctgggt atggagcggc ttccacagcg gacgggcttc aatgttttct tcagcaagac 3176221 gttgaactat gtcatatggg ctgagcccgt tatcaagtgt gagcgtggtg agccagcgat 3176281 tggatacgcc tgctgcgtac tctggcataa agcggacgcc gtctaagtga ccgagcgcat 3176341 ttttgtatct cgtgaaaatg gtccttcttt tctccactcg ctcatccagc acctcaagct 3176401 gggcaatgcc gacgccggct aagatattgc tcagcctgta attatgtcca atttcactgt 3176461 gctgataatg aacagccggc tctcgtgcct gcgaagcgag aaatcttgct ttttcaattg 3176521 cggcttcatc atttgaaacg agcatccctc cccctgatgt ggtgatgatt ttgttcccgt 3176581 taaatgaaaa aatgccgaag cgcccgaatg ttccgctttg cttcccttta tagactgtgc 3176641 cgagagattc ggctgcgtcc tcaatgacag gaactccgta tgcatcacac aggcttacga 3176701 tttcatccat tttcgcgctc tgcccatata gattgacggc aattaccgct tttggcagtg 3176761 ttccgtttct tttcgcttcc tccaatgctc tttcaagggc tgtcggcgac atattccacg 3176821 tatcaggctc agaatcaata aagacgggca ccgctttttc atatagaatc ggattggcgg 3176881 ttgctacaaa tgtgaaggac tggcaaaaca cgctgtcacc ttcttttacc tcaagcaaac 3176941 gcagcgcgag atgaatcgcc gccgttcctg agccgaccgc agctgctgct tttacaccga 3177001 ctcgttctgc cagctgttct tcaaatgaat tcacgagcgg cccaagcggc gcaatccagt 3177061 ttgagcgaaa ggcttctgaa atatagtgct gctccctgcc gctcatatga gggggagata 3177121 agtagatttt tttatgcata gaatcatcct ttgtttgatg tttgaatgga agaaatgatg 3177181 cgtgccggag caccggccgc cgttaccctg tccggtatgg aacggatcac cgcggagccg 3177241 gctccgacaa tgctccaagc cccgattatg atctgcggta tgacggatgc accggttccg 3177301 acgtgagcgc cttcctgaac ggaaaccgct cctgacagcg tggcacgcgg ggacagatga 3177361 acgtaatcgc tgatttgatt gtcgtgctct gccactgcac ccgtattgat gatgcagtgg 3177421 gcgccgatgc gcgcatccgc ctgaatgatc gcgcccgcca taatcactgt cccttcccca 3177481 atgacagccg acttgctgac gatggctgac gggtgaatca atgtaataaa atcatctttc 3177541 cccagtccca gtcgctccgc cagctgtttt ctgacactgt tattcccaac agcaatcaga 3177601 aacagcacat caggaatgag cctgcgcagt tcagtaacgg ctttcggcgg tcctgtgtac 3177661 cattcttttc cgccttcgaa cgttttgaat ttatcatcca gcaccgcggc taagcgcgta 3177721 tctgagcggg cgtttatcag ctctctgatc acctttccgt gaccgccgtc acccacaatg 3177781 gccacatttt tcatgaggac acatctccgc ttccggtaaa ccgttccgcg gtcacatgat 3177841 tggtttgctg aatcccttct gaaacaagga cctttcgcac cgtcaaacat aaaattttca 3177901 aatcgagaaa aaatgaccag ttgtcaacgt accaaacatc taattcaaat ttcttttccc 3177961 aggaaatcgc gtttctgcca ttgatttgcg cccagcctgt gatacccggc ttcacctcat 3178021 ggcgccgtgc ctgtttttct gtataaagag gcagatagtc catcaaaagc ggccgcggcc 3178081 cgacaaggct cagatcgccc ttcaggacat tcaggagctg cggaagctca tcaatgctca 3178141 gctttctgat cagcctgccc gttttcgtca gccggacttc atcaggcagc agatttcctt 3178201 tactgtcccg ttcatccgtc attgtccgga acttatatag ggtgaacggt ttgccgtgca 3178261 ggcccggcct tacttgctta aagaagacag gtgatcctat tttcagcctg acaacggcga 3178321 tggtgaacag aatgatcaca cttgtacagc acaacaaaaa aatggcggcc gtcagatcaa 3178381 aaagtcgttt caggatcaaa gattcacagc tcctttcgtt tttcgaaacc gttttaatac 3178441 cagctgtctt tcctcttttg tacaaacgag cataaaagcg aaaacagcgt agcaaaagct 3178501 gactgtcact cccgtcgcta tcaatgacgg ccagctgtca atcttcacaa tgaactgaat 3178561 tgccttacag accgtccagg caaatacagc ggctgaaaga ggcccgatta tgcctttaag 3178621 gaacacgtgc tttttgtagc ctgtaatgcg ggatacgtaa agcggcgtaa agatggcatt 3178681 ttttaaaata agagaaatgg cccctgccaa tgttatgccg tacagaccga gatgagccgg 3178741 cccgctcagc gtgaccgcca gcaccacatt caccgcacct aacagcaggg taacaatcgc 3178801 cggtgttttt tgttgattaa aagcggtcca tatataaaac agcggcataa aggcgaggct 3178861 gacaaccaag tatccggcat gaataaataa aagcggtgct atcgttgaaa aggacggtcc 3178921 gagccagatt gtcagaaaag gtcccgccaa tccgcccaat aaggcagcag gaagtgcaag 3178981 caaaagacca ttgagcctta ctgccttatt ggcgtaattc atcaatcctt ccatatcgcc 3179041 ttttgaataa tatgaagtca tgatgggcgc aaacagggat gcgaccgttc cggccaagct 3179101 gcgcaaaagc agcggaaact ggataatcgc cgcgtatttc ccggatgcag acgcccccag 3179161 catcaaattg gcggttaaca gatcaatctg caaaaaaagc aggacgccga tttgattgac 3179221 ggagctccat gcgcccgctt gaaacagctc cttgcttgta cggaatgaaa gatccttcat 3179281 acgaaacgaa aaccacggaa tcagcttttt gaagaaatag aaagacagca cagacgcaat 3179341 aacagcacca gctaaagctg caagctggat ctgccagatt ttcggcgcaa agcatgcaaa 3179401 caggagcagc acagacagca cccgtataag catttgcacc gcctgaatgg aactggtgat 3179461 ataaaggcgg ttggcataaa atggtgcagc gccgaagccc gccatcagaa acgttaaaat 3179521 aaacagcaca ctgccgatta aaatcgacaa acgcacatct gccaaaagcg cttgcggcac 3179581 attcatgacg cggtcaataa aaaaagccga acccgcaagc ggcagcaaga gcagcaagga 3179641 aatcaaaaca gaggcggcta aataattgct gatatacgca tttgctttct cccgctctcc 3179701 cctgtgggca gcaacagaaa agaaccgaac gacaaccgag ctgagcgcca cggtaataac 3179761 cgaaaagtaa ttaatcacat tttgtgtcaa gtgaacaaag ccaaacgctt cgacaccgag 3179821 cgttttgaca ataaaaggcg tcatccaaac cgataggaaa acagacaaga gaaaagccgt 3179881 gagattcgcg ctgaaattta tcgtgaattt catgcctgct tcgcactgcc tttcattgtc 3179941 ccccgctgct cgaaaaacag cttgatgaga aaagtgagcc gccatttaca cagtgctaat 3180001 accaaacgct ctcctcttaa taatttctca tgctgaaacg gtgtatgtct gacagcctgc 3180061 cgcaccatgt cataggataa aatctgtctg atcttctttt tgatgtcttt cggcgaattc 3180121 ggagaagcac aggcatttgc caaaagcatc ggaagctggt gcctgcaaat gtacacattc 3180181 aaatcttctt tacatgcgcc tgctaagccg tagtgattgt agaatgcgat tttagcctga 3180241 tattgttttt gaagatgttc atccatcgcc ggcttataag ggatttctgt caggctgttc 3180301 gggttttcac gataaatgta caatccttca tcaagcattt tcacccgctc cgcttcgcga 3180361 aaagcggaca aattaaaggg agagtcttca gcaaaacgga tgtcttcatc aaacagcaga 3180421 ttcgcccttt caaaaagctc acgacggtaa agataacgcc atacatacca gataaatctc 3180481 gtttcgtgag catgtttaag ctgttcagtc atttctggtt tcgtcagcac gcggtttgcc 3180541 tcaagctgcg gcggcacata tgtccgcctg tccgatgact gcttgtaaaa accgcatccg 3180601 acgatgtcaa gctgattttg ctccgcttct tcagtcagcc tctggaacat ggcggatgat 3180661 acataatcgt ctccgtctac aaagccgatg taagtgcccc gcgcggcctt tattcccgta 3180721 tttcgcgctg aactaagccc gccgtttgcc tgatgaatga cccggattct cgcatcccgt 3180781 tttgcatagt cctctgcaat ttcgcctgaa cgatccggtg ttccgtcatt cacgaggatg 3180841 atttcaatat cagaaagcgt ttgacgaagc aaagaatcaa tgcactcttc tataaatggt 3180901 tcaacattat acatcgggac aataatgctg acgagcggga tcattgcgct tcaccgctga 3180961 ttttgtcacg cagaccttta aaatacacat ctctcggaaa gcctgcacgg gatgtttctt 3181021 ttgttaaaag ctcattgact gcggctgtta cgcgctctgg ctccggatgt tctatcagct 3181081 tcatgaacgg gatgtcttta agccattgat agccctccat caccttatgg tcaaaggagc 3181141 gaatgacaac acacggcgtt cctgtcagcg cgcaaaaaat catgccatga agcctgtcag 3181201 tgacgacggc ttctgcgctt tgcagcttag accacagtgc ttcaagttca tgttcgcgtg 3181261 tatcgcggct gacccggcgg ccgatcgttg tcgtaaagga tttgatctcg ccgaattcct 3181321 cacatagcgc agccttgacc cggttcctct gctcctcctg aagcacgctt tcctgatcct 3181381 cgcgcaaaca catataaacc ccttcgcgtt ctgcgggagc cttgcttctg tctaaataca 3181441 gcaccatgtc cggctgcttc aaaattgttt tttcttgaaa atgctgtttc ataaattgat 3181501 acgttgtttc atcccgcgcc atcagcaata ggccggggtg cgcattataa attttctgtg 3181561 cccgtttcag ctctttgcgc ccttttttcg tgtcagaaaa atgagccgtt gccggaagct 3181621 ggacaacccg atagtcatgg aatgttttaa tgatgaagcg gcgcgtccac tcctcataac 3181681 ggtataaatc ccccatgttt ccgccgccga tgataaagac catatcctcc ggatggcgcg 3181741 agcggatcag gctttttgct gatttgtaaa tgtccttcat atcgacctcg acgatgtcaa 3181801 agtccgggta ttcttgctca agaaatgcct tgctggcata agcaattgcg tgatctccca 3181861 aattgtcatg ggacggcagc agggtcagta tgattttttt ctgatgtgct gcggccttta 3181921 ccggttgatc tgccgctccc agccaatatt gggacgggta tttgaccttt agcagcagcc 3181981 attctgcaaa attgattttc aacgattgta acgacatgtc ctcaccctct gtttctcatt 3182041 ttgtactcga tcacccgctg atacacagcc gatgccatag cgacgaacgg aatcattctg 3182101 tatttcgcca tcagaagcag gcatgaccgt tttgcgtcaa aaggagcagt acccgttttt 3182161 gaaagacttt cttgaaacac cgggtccgcg catatcacgc caacatttct aagcttttca 3182221 aacagccggc ggctgccgct cgttttccat tcattcagca tacagatgct gctgtgaaga 3182281 acgataaagg tatcaagctc cttgcgatac tcctccagtt tgttgttctc ctgtaaaaac 3182341 gccgcattcg tctcatacag cgcaagtcct gattcaaaca attttttctg atagcgctgc 3182401 acaatggagg aaaggtgaat tcgataatga tagagcggcg tttttacgta ggatactgag 3182461 cgggcgaaaa aatgagccct gaagctgaaa aactgatcct cgacatgctc cagctcgcct 3182521 cggagcggaa acgacagccg atgggcttca atcatgcttc ttctgtacag tttgttccat 3182581 gaaaaccctc tgaccttccc ttcgaataac gccttgatat agtgctcctt cggctgatcc 3182641 tgataggttt gggcaatgtc agagtccatg gttttgccag tgtcctcaaa ctctgcggcg 3182701 taattgcaaa tgaccagatc agtttcatcg cctgctgtcc ggagcatctg ctcgcaataa 3182761 tcaggctcaa tccaatcgtc tgaatcgata aacgcgataa attcgccgcg tgcagcttca 3182821 atgcctttat tccgaaccgc accgagtccc tggttttcct gatgaatcac cttgaacctg 3182881 ttgtccattt tggcgtattc ttctgcgata tccgggctgg cgtcagctga accgtcattg 3182941 acaatgatga tttcaatatt gtccattgtc tggttccgca gtgattcgag acacgttctg 3183001 atatatgttt ctgtgttata aacagcgact aacagactaa ccgcaggtgt ttccataatg 3183061 accggctcct cgtgcataaa ttaccgggaa aaaatcgttc tgtaaggcag aaccgatgaa 3183121 tcgaccggca taagcaaata actgtaaaga aaataacaaa caacgatagc gatatagata 3183181 agagcgttcg atttttcatc aaatatcctg acgaaataag ggactaggat catttgatac 3183241 agaccgaaat aaatattgaa tctggcaaaa atcacgtcct ttgtggccaa aaggccgaac 3183301 aaaaaaccta gcaggcacaa attgacgaca atatcaattt gcggccacag actccgcagt 3183361 cgttctttat agcaaaatgc aaggaacagc ggcagaacca aaacagcgat tttgatcaca 3183421 ttcattccat ttgtgttcgt catgagccat ttttcataat ggctgtatga gctgttttca 3183481 agtacaacga caaacacaga aataaatttt tgatataaaa atgtcatgcc gagaaataaa 3183541 gcggataggc cgaatatcgc cggtgaccag gcttttcttc tgacaataaa gtacactgga 3183601 atcataatca gcgccgacga atgaaagagc gagctgacca gcacaatcag gaaatatcgc 3183661 ttccagttcc cgctaatgat ataacggatc gcccaaaaca aaacagctgc caccatgtat 3183721 tgcctgatgc cgttaaaaga tgcgtaataa tgaaaggttc ccaaaaataa aaagacactc 3183781 agctcaaacg gcctgccata gtcggcgagt gtcttcataa taaagctgta ggtcacgacc 3183841 gccaccgtaa aatacatgat ttgaggatct tccgtgatga aattcatcag ccaaaggagt 3183901 gcggtaaacc ccggatctgt cgctgttttc gctgtgccga aaccgaatat ctgccacaca 3183961 ttttgataat cgcccgccaa ttcgtacaac agcgtgtacg tctgaaaatc cgtgccgact 3184021 cgatagcgga gacctgacac gagcacaagt gaagcgagcg gaatccagat caaaagctta 3184081 ttcggccgat accccgtggc aagcgaatca tcacggccgc cgcacatttt agcgaaccaa 3184141 gaccaaataa atacaatccc catattgacg gcatatacaa tcatcggtta tggtcctttt 3184201 ccgtgctgat gttgtataca ttcagcagcg ctcctacatt ttgctgtgca tcgtagccaa 3184261 gttgagcgag tgtttctttg atgaactcac gcttcggcct gcctgcggcg gccgcccttg 3184321 caatggtttc agcccagacg ctgatcggct cagaaagact taatcttgtg acaagcccga 3184381 gaccggcgtc gactttttct gtaatgctgt ctgaaatgat gcatggaagc cccgacgcct 3184441 gcgcttccac aagcacaacc ggcaagcctt cgtacagaga cggcatgaca aatacatcga 3184501 atgttcgcat cagttcatgg atccgttctt ccgtgcctaa aaagaggacg tctgatagca 3184561 aattctgctg ccgcgcctcc tcctctatct ccccgcacaa cggcccgtct cccgccagaa 3184621 cgagctgaaa gcgaatgcct ctttccttga gatgtgcggc aagcttcaac aggaacgcgt 3184681 ggtttttcac ttcatgaaac cgggccacat ggccaatgat gagccggtcg gctgcaatgc 3184741 cgcgtgctgc tttttcttca tcagccgcct gcccatttgg ggcgaacaac tcaaggtcaa 3184801 tcccgttagg aagaaggtga acacgctccc gctccatatt ggactgtcca aataaaaacc 3184861 tgcccgcatc ctctccgcag gcacacagcg ctgtcgcatt tgccaaaatg agccgcctga 3184921 acacgagcag ctgcaatcga tccttccagt tgaagccggt cttccaagac gtattgtggg 3184981 agtggcatac cctgaccggc actccggcga gccttgccgc aagggcgata aaacccgttt 3185041 ggaaatccgt gtgcgcatga acggcgctga acggcccatt ttcttttatc gcgtttctca 3185101 cattcctcac aaatgtaagg ggattgcttt gcccaatgct cgggacataa aaaagccgcc 3185161 cgcctaaaga taaaatctct tcatcataag cgcacggatc atttcgatac gttaaaaaat 3185221 caaattgcac tttgcttttg tccatcttcc gatataaatt cattaccatg gtttccgcgc 3185281 cgcccctgtt catgccgctg agaacatgga gcacgcgctt ttggctgcta ttcatgcttg 3185341 acaagccctt ccttttggtt catcactctt tttttatggt agcgattcat cacagctgca 3185401 ggcataaagg cgcgaattaa cggttttgcg atatatatgt aatcagataa aggaagcttc 3185461 aagcgtctgc acgcctgata gacaagaatg gcattgtcga ttgaatacgt aaatgaccgc 3185521 cgtttgaatg catcgctgtc ttccctcact ttatacaagg cttcctgaag attatagccc 3185581 ctgaagccct cttcaaaaaa gcgaagccac aaatcaatat cttccattcg tctcgtccgc 3185641 cgcaccgacc ggtagccttt cagcgtgcgg taggcactcg ctctcatcat aatcgtgccg 3185701 tggcaaaatg gagtcccttt tgccatgatg cccggctccg gaacagaagg cagaatgcgg 3185761 gcgcctctta cgccaaattc atcaaacaca agcatgccgg tgccaaccac ctgatagtgt 3185821 cggtgctttt ctaaaaacgc gacctgcttt tccagacggc gcggaaacga aaggtcatct 3185881 ccgtcctgac gtgcgatata atcgcctgtc gcatgcgaaa gacaatgatt taatgatgcg 3185941 gcaagccgct tatttgtttt gttttgaatc agtttgatgc ggtcgctgta atgagcggca 3186001 tactgcttcg cgatacggag cgtgccgtct gttgacgcat catcgcacaa aatcagctcc 3186061 caatttttat aggattggct gagtatggat tctatgcttt ctgccaaagt gcgttcgcaa 3186121 ttataaatgc ccataatgac agaaactttc ggtcctgagt tcatacgctt ttctcctttg 3186181 tatccatatc catgtacgcg gaataaatat ctgccatttc ttccaccgtt cgcgcctccg 3186241 agaagcgcaa ggctgttttt cggccttcct gtcccagctt tcggcagagc tccggcttat 3186301 ggtaaagctg ttcaatccgg cgggcaaaag cagcactgtc accgattttg atcagaaaac 3186361 cgttttctcc gtcgcggatg atttcccgat gcccgcgatt atctgtggcg atcgccggtt 3186421 gttctgccgc cattccctca agcacattca taccgaggcc ttctctaatg ctggatgcga 3186481 cagatacatc cgcaagctga atcaactcat gtatgtcgct gcaaaagccg taaaaacaga 3186541 catgggcgga ggcaccaagc ttttcagcta acgtttgata cgtatgttcc attgcccctt 3186601 ccccggcaaa cacaaggcgg agtgagggaa ttttttcttt tagcaaggct gcggcttcaa 3186661 ttaactgctt ctggtttttg ttcagattga gctcagccgg ataaaccaat ataaaatcat 3186721 cttcacggaa cccgtgcttt tctctgagtc tttgctgctc tatcggactg acaggccgga 3186781 aacgctcggt attgacgcca atgccgtgaa ttttctgcgt ccttccgccc ggcctttgaa 3186841 gtcctttcgc ccgtatgtaa tcctcttcat taatcgtaat caggcagtct gtatatgctg 3186901 aaagccattt ctcaaccgga tagtaaagaa gccaattttt catcggtgcc cctttgcaga 3186961 agtgaaatcc gtgcgctgtg tacagcacct ttgttccgtg ccgccgtgcc tgcctcgccg 3187021 ccagtctggc gagaacgccg ccgaccggtg tatggcaatg gacaatgtcg tattcataag 3187081 tgtcaatcac tttcttcagc tgcctataaa cggccaggtt ctgagggtca aaaggtgacc 3187141 tgcgaatcgg gatggagaat ttctcatcca catacggcag cttggtttgt ccgttcgcgg 3187201 cgacatgaac ctcccagccc atttgcttga accatttaaa ataagggagg tgaaaggcct 3187261 taaaatgata atcaacagtc gcgcaaaaca atatcttttt cgtcattttc actcccccta 3187321 atgaacgctg gcagccgtca tttcttctga tgtattgatt gccgcaaaca gcctcgctct 3187381 caggtcggct tccggcagct catgaaaatc ctcgataaag cgcatcagca ccggccaatc 3187441 gccgtccacc gctttaccga tgtgaatttt tggaaagatt tgttcagcat ggacttcatt 3187501 tttgttcagc aattcttcat acattttttc gcccggacga atgcctgtga attcgattgg 3187561 aacctgctca gtcgtgtagc cggacaaatg aatgaggttt ttggcaagat ccacaatctt 3187621 tacgggctct cccatatcga gaacgaaaat ttgacgccct ttcgccagtg ccccagcctg 3187681 aatcacaagc cttgatgcct cgggaatcgt catgaaatag cgggtcattg ccggatgtgt 3187741 tactgtcacc gggccgcctt tttcaatctg ttttttgaaa attggaatga cgctgccgcg 3187801 gctcccgagt acattgccga agcgaacagc aacaaatttg gttctgctga ctttcccaag 3187861 attcataata atcatctctg cgaatcgttt tgtcgccccc attacgttgg ctgggttcac 3187921 cgctttgtcc gatgaaatca gcacgaatgt ctcagttccc gacatatcgg ctgcttccgc 3187981 gacatttttt gttccgataa tattgttttt gaccgcctct tctggattgt gttccattaa 3188041 aggcacatgc ttatgggcag ctgcatgata gacaacatgc ggctcgtatt ttttcatcaa 3188101 ggtaaacatt ttatcgcggt cctgcacatc agcgatttcc gtatggaaca caatgtgttt 3188161 gccgaatcgt ccgttcagct ctgtataaat cgaatgaatg ctgttttccc catggccgag 3188221 cagaatgatt tccttaggct gaaacgcgct gatctgacgg cagatttccg agccgattga 3188281 tccgcccgct cccgtgacga gaactgtttt tcctttgatg cggttcgaaa tttcgctagt 3188341 gtcgagggtt accggctttc tgccgagcaa gtcctcagct tttacatctc tgatttgtcc 3188401 ggcagttcgt gtgccaagca gcatttcatc aaaatgaggc ataattttaa tgcttactcc 3188461 ggttcgcaca cattctttat ataacacctg aagctcatgg gtgcggagtg aaggaatggc 3188521 aataataata taattaattt tgagcttttg caccgcaggc atgatacttt cttttccgcc 3188581 gattacgggc agccccataa tttctaattt atgcttcgtt tggtcgtcat caataaaagc 3188641 gacaggtatg atatcaggtt catctttcga aagcagctgc ctgaccatca gagtcccacc 3188701 tgagcccgcc ccgataatca gcgcgcggga cgaggcgcag cgttttttcc tgatgctttc 3188761 gtttaatact ctggataaaa tacgggtccc tccaatagac aaaagctgaa gcacccagca 3188821 cgcggttaac agacggaaga acatcgtgtg atacacagca tactgaatga cgccggtcac 3188881 agcggctgaa agcgtaatgc ccttaagcag gacaatcagc tcgccaagcc cggtgtatgt 3188941 ccacacctgt ttatactgat tgaacaggaa agcacacaca tgatagctga ggagcaagct 3189001 gacagcggta agcagtaatg ctccggagtc ataaaattga taggaatctt ttaaaaattg 3189061 atatcctgca ataactgaat ttaaaacgag gtaagtatcc agcgcaataa tcattgacag 3189121 tcttctccgg taactcaacc ttttcccccc taattctttt atcggtttag ctgcggcggt 3189181 tttcgtctct ccaaaaaatc ggcagcagct aaaccgacaa tacgtcctat gtatatatga 3189241 gataagtggg catttaaccc atcctcacgc cccgccagcg acgaccagca tctaaggcag 3189301 caacttcagc tgcccacagc agagccgagt gcctccattg atacaggtca ggagacatca 3189361 cctttacaaa aactagtagg aatagtgttc cgattttttc attttctttt tgtttaaaag 3189421 agcgcctaac agcttcgcat tggattgttc cagtgcatct tttgctttca gaacggtatc 3189481 ggtttttgtt tttccgctta aaacgacgag cacgctgccg tctgtctgat ttgctagaat 3189541 ctgagcatct gcaacagcca aaagaggagg ggaatcaaag atgacgaggc tgaattgttc 3189601 atagatctca gatattaaat ctcccattgc ttttgaagac aacagttctg ccgggtttgg 3189661 cggggtcggc ccgcttgtca gtacatataa gttatcgatc ggcgtctttt gcaccgtctc 3189721 actgagtgaa gcattgccga ccagcacatt tgtcagcccg gttacattat caacctgaaa 3189781 cgtctgattg atggtcggct ttcttaaatc ggcatccacc agcagtactt tcttttcctg 3189841 ctgctgcgca aagacagccg caagattcgc tgcactgaac gatttacctt caccaggcac 3189901 agaggaggtg acgaggatag atcgcaagtt ggtctggaca gatgagaact caatgtttgt 3189961 ccgaatggtg cgatattgtt ccgcaacaac tgatttattg tgtaaaacag atatttgagc 3190021 caaacctcgc cttgctttct tttttctaaa gatcactcgc ttcactcccc gaaatgtttt 3190081 atcccgcgat tccgcccttt gtggacatca ggaacggagc ctaagcatgg caatccggtt 3190141 ctctcgctga gctgccgtgc gcttttgcat gtatcatcga gaaaatgcag aaaaaatgcc 3190201 agtgtaatgc cgcccatgac agcagcgcca aaagccatga ccatatttcg cagcctggcc 3190261 ggcttgatca tcgggctttc cgaagccttc gcctctgata atatatgtac gccttgtaca 3190321 ttcattcttt catctacttc tttttcaaac ttgttcacta acgtgttcgc aatctcagct 3190381 gctttcgccg gatcgtgatc ctgaacggca acgttgatta tttctgattc attttcactg 3190441 ctggtaacca cttttccttt cagcgaggaa gccgattcag ataggtgcaa ttccgcctta 3190501 acttcttcca tcaaggcagt gcttttcata atcgattgga acgtgctgct atactgaaga 3190561 tttcgctgga tgtcactgag attcgagttt tcttcaccgt ctgattcatg aaccagcacc 3190621 tgtgtcgacg cctggtaggt cggtgaaatg accttaaatt gcacaaaacc cataataagg 3190681 gtgacgccga ttgtgatgag cagaatcagc acgaatctgt gtctgacaat cgcatataat 3190741 tctttgaaac tcatattctc attcatgtat tcatagcctt cagccttccc gcggctggct 3190801 tcccgcgccc ctttctgtta atgattggat tataaaagaa aacgttatta tttaaaaatt 3190861 gcaaaataag ccaataagtt ctctttagag aacaaaatca tgattttcct ctaatttact 3190921 gcacttccct tattatttta aattttataa agaacgaaaa attccttata atgaacgaaa 3190981 taacgacagg aatagaggag aatttcatat tatgattgga agaattatcc gtttgtaccg 3191041 taaaagaaaa ggctattcta ttaatcagct ggctgttgag tcaggcgtat ccaaatccta 3191101 tttaagcaag attgaaagag gcgttcacac gaatccgtcc gttcaatttt taaaaaaagt 3191161 ttctgccaca ctggaagttg aattaacaga attatttgac gcagaaacaa tgatgtatga 3191221 aaaaatcagc ggcggtgaag aagaatggcg cgtacattta gtgcaagccg tacaagccgg 3191281 gatggaaaag gaagaattgt tcacttttac gaacagactc aagaaagaac agcctgaaac 3191341 tgcctcttac cgcaaccgca aactgacgga atccaatata gaagaatgga aagcgctgat 3191401 ggcggaggca agagaaatcg gcttgtctgt ccatgaagtc aaatcctttt taaaaacaaa 3191461 gggaagatga tgatcggtta aagggctaac gttcgcatct ataggggaaa tctgtttata 3191521 atgggggaaa aagggagaga acacaatgac tcatcaaata gtaacgactc aatacggcaa 3191581 agtaaaaggc acaacggaaa acggcgtaca taagtggaaa ggcatcccct atgccaagcc 3191641 gcctgtcgga caatggcgtt ttaaagcacc tgagccgcct gaagtgtggg aagatgtgct 3191701 tgatgccaca gcgtacggct ctatttgccc gcagccgtct gatttgctgt cactttcgta 3191761 tactgagctg ccccgccagt ccgaggattg cttgtatgtc aatgtatttg cgcctgacac 3191821 cccaagtaaa aatcttcctg tcatggtgtg gattcacgga ggcgcttttt atctaggagc 3191881 gggcagtgag ccattgtatg acggatcaaa acttgcggca cagggagaag tcattgtcgt 3191941 tacattgaac tatcggctgg ggccgtttgg ctttttgcac ttgtcttcat ttaatgaggc 3192001 gtattctgat aaccttgggc ttttagacca agccgccgcg ctgaaatggg tgcgagagaa 3192061 tatttcagcg tttggcggtg atcccgataa cgtaacagta tttggagaat ccgccggcgg 3192121 gatgagcatt gccgcgctgc ttgctatgcc tgcggcaaaa ggcctgttcc agaaagcaat 3192181 catggaaagc ggcgcttctc gaacgatgac gaaagaacaa gcggcgagca cctcggcagc 3192241 ctttttacag gtccttggga ttaacgaggg ccaactggat aaattgcata cggtttctgc 3192301 ggaagatttg ctaaaagcgg ctgatcagct tcggattgca gaaaaagaaa atatctttca 3192361 gctgttcttc cagcccgccc ttgatccgaa aacgctgcct gaagaaccag aaaaagcgat 3192421 cgcagaaggg gctgcttccg gtattccgct attaattgga acaacccgtg atgaaggata 3192481 tttatttttc accccggatt cagacgttca ttctcaggaa acgcttgatg cagcgctcga 3192541 gtatttacta gggaagccgc tggcagagaa agttgccgat ttgtatccgc gttctctgga 3192601 aagccaaatt catatgatga ctgatttatt attttggcgc cctgccgtcg cctatgcatc 3192661 cgcacagtct cattacgccc ctgtctggat gtacaggttc gattggcacc cgaagaagcc 3192721 gccgtacaat aaagcgtttc acgcattaga gcttcctttt gtctttggaa atctggacgg 3192781 attggaacga atggcaaaag cggagattac ggatgaggtg aaacagcttt ctcacacgat 3192841 acaatcagcg tggatcacgt tcgccaaaac aggaaaccca agcaccgaag ctgtgaattg 3192901 gcctgcgtat catgaagaaa cgagagagac gctgatttta gactcagaga ttacgatcga 3192961 aaacgatccc gaatctgaaa aaaggcagaa gctattccct tcaaaaggag aataaatatg 3193021 gggaaaacag gatacattgg tgctgccatt gttgtggcag cttgtatcat tattttgtcg 3193081 gccgtggtat gtttacggga cacagtctat taccagccta tgcgctggac tggcatcata 3193141 ctgtttttcg cgggaattgt gatggttccc gcatactcag caaaaagaaa acccggaaaa 3193201 gagaagtaat tctcttttcc gggtttttat gtttattata atcttcccgc gcgaatatcg 3193261 tctgtcattc cctcataagg agccttcgaa atcacttctt cgttgtcgac tccttcattt 3193321 ttcagaaatg taatttccgc aaattcaggt acaacgtatt ttggatacgt ttcatatttt 3193381 tcgcgggatt ctttcatcaa atcaatgtgg tcattttggt agcaaaccgt aatttcagga 3193441 tgttcatgca cccatttcgg gaagaaaata atgccatgca tgcgtttttc atttggcata 3193501 aagtttaatg aaacatccgt gccagtcggc tctgtccaag acactttata tacgccttct 3193561 gtcagtttga caatattcac ttcctgatct cgaacccagc gtccggcaac cattccgcta 3193621 tgaattctat aatcaattgt atggtcgttt ttaatataaa tctcgtattc ccatccgttt 3193681 tcatacgtat aaatcatgtg gcttccgata aagttttcca tcttacacac tctccttagt 3193741 cttttactgt acttcataaa tgtctagtag aacgtaatca ggggttcttt ctgcggaacc 3193801 gataaacaag cggtcatgga gccattgata gacttcactg cctgtttcaa acgtcggtac 3193861 cgtacgaaaa taaacatgct ccggttcaat aatttccccg gctgccgctt gttttcgaaa 3193921 cggcttgctg acttgccgta ttccattgtt ttcaatgtaa atcagttcat gatctgctgt 3193981 ttcaatcaca tacctggcag ataaatctgt tctgccgtta gcgcgaatca tttgtgaatc 3194041 ggcaccgccc ggcaaaatac gtccctttac ttccccggtt attgttcccg aacgaatcgg 3194101 aatgaatcat ctcagtccca ggcttgtctc accaatcgtg ataggcggat caaccttgat 3194161 ttctaaagag gcgaatggtt ttaaaaccgg cttcttcacg agaaccacct caccttcaga 3194221 aaaaatcatg taactattta catgttcact ttaacaccat tgcagttaac tgtcaaacaa 3194281 taggaacata aaaaaacaag gactgtttga agacagtcct tgtctgaagc tagctttgat 3194341 aagcaagata tgtgctgaca gtgcttttgg caagacaggc agaggaatct ataatcggaa 3194401 tctcactttg aatatgatct aacaccgcat ttaaatccgt gcaggctgaa atgatgatgt 3194461 ctgcatgctg actgatttct tcatatagcg tctgccacaa tgcttgtgta tgctgcatat 3194521 gatttggctg tttgattgcg gcgataagct ggttcacagc ctgctgccaa tggtccttgt 3194581 gaataacttc ttgtccattt cccttcagaa ctttttggta gatggcggat tggatggttg 3194641 gctctgttcc taaaaccacc gctttttttg cgggatgcgg aatctctttt atcgtttcct 3194701 caacaatatg caacatagga actgacaatg cctgctgaat ctcttcatag tagacatgcg 3194761 ccgtattaca aggcagcgca atgaaatcca cgcctgtttt ctcgagcttt accgctccgt 3194821 cgataatcgc ttttttcatc tcgtcatggt caattggacg atctgcatag aagggcgtcg 3194881 ggcatgaata gatcatcatg tgcggatagt caatatcgtt tgaagcccca tacagcttct 3194941 gacagtaatc aatcacctta tcaataaacg gcgaggtcga tttcggcccc attccggcta 3195001 atattccgat catcaaattc attcctttct acttcgtacg gaccgcttct tcctctgagc 3195061 catcctcata gaggataaag cttttcgcag catcctcacc taatgtaaac tcgacttcaa 3195121 cagacaatgc tcgcagaaag aaacgggttt ccgaggaagg aaataactcc agtctcagct 3195181 gtccggcgat ctccaaataa agccgttcat tctcggttgt cacctgtgca gccgtcccat 3195241 cctgcaacag gtagctgcca acatagcggc tgtatatcgc cgtatcaatt gcttttttct 3195301 ttttatcagc aggacgttcc gggacatcat atggctggcc aaatagaata tgttccgccg 3195361 ccttcagaat cgcttgttca tattcagtat cctcttcctt attactcaaa tagatcagcg 3195421 ttttacgatg atcgatatat cggatcatca tcgtcgaata gccgggccat cctccgctgt 3195481 ggctgacaat ccgccctttt tcaggactgt tttgcagcac ccagccaaag ccataatcaa 3195541 ttgtttctcc attgttgagg cgcactggag aaaacgcaga ttccttagaa gccttgctga 3195601 tgaaatcgtc ctgatataaa gcctgatcaa atcgaaacaa atcgcttgtg acagagttaa 3195661 ccgtcccatc tccctgtatg ccatcgagat acacaacata gttcgtttcc tccagctcat 3195721 cagggaggac gtatgtttcg gaatgtacat catacacata tccatatgca taatgatcaa 3195781 ttcgctcagg cgaaagcctc ctgttataca ctcttgtttc attcatgcct gccggtaaaa 3195841 aaatacttgt ttttataaaa tccgcatagc tcatgccaga tgctttttca atgataaccg 3195901 ccagcagcac ataccccgta ttgctgtaca tccagccttc attcggttca aaataaccag 3195961 atagcccctc attcatcagc atatcgacaa tatcctgatt caccgcaatc ttgtgtgaat 3196021 cccaattggc aaaaaaccat cccatataat caggaagccc tgacgtatgg ttcaataaat 3196081 gccgaatcgt tacgccctga tacggaaaac cgggcagcca gcgatccact ttatcctcat 3196141 agccaagaat ccccttctcc tccagcaaga tgattcccaa tgctgtaaaa ggctttgaca 3196201 aagacgctaa ctcaaacaaa gagttggttt tcaacgggcg tttttccgtc atttccgcat 3196261 agccaaaaga gtggtgatat aaaatatcgc caccctccgc agccagaacc gtcccgttaa 3196321 actgatgttt ttcgcctaat gtctcaaata acgtctgaag atgctttctt ttattctgct 3196381 tcattcctcc acctcccata tctctgtacg ttactaacct actaacgttt caaatatttt 3196441 gaaaaatcct tcagttagag atccttttta acccatcaca tatacctgcc gttcactatt 3196501 atttagtgaa atgagatatt atgatatttt ctgaattgtg attaaaaagg caactttatg 3196561 cccatgcaac agaaactata aaaaatacag agaatgaaaa gaaacagata gattttttag 3196621 ttctttaggc ccgtagtctg caaatccttt tatgattttc tatcaaacaa aagaggaaaa 3196681 tagaccagtt gcaatccaaa cgagagtcta atagaatgag gtcgaaaagt aaatcgcgcg 3196741 ggtttgttac tgataaagca ggcaagacct aaaatgtgta aagggcaaag tgtatacttt 3196801 ggcgtcaccc cttacatatt ttaggtcttt ttttattgtg cgtaactaac ttgccatctt 3196861 caaacaggag ggctggaaga agcagaccgc taacacagta cataaaaaag gagacatgaa 3196921 cgatgaacat caaaaagttt gcaaaacaag caacagtatt aacctttact accgcactgc 3196981 tggcaggagg cgcaactcaa gcgtttgcga aagaaacgaa ccaaaagcca tataaggaaa 3197041 catacggcat ttcccatatt acacgccatg atatgctgca aatccctgaa cagcaaaaaa 3197101 atgaaaaata tcaagttcct gaattcgatt cgtccacaat taaaaatatc tcttctgcaa 3197161 aaggcctgga cgtttgggac agctggccat tacaaaacgc tgacggcact gtcgcaaact 3197221 atcacggcta ccacatcgtc tttgcattag ccggagatcc taaaaatgcg gatgacacat 3197281 cgatttacat gttctatcaa aaagtcggcg aaacttctat tgacagctgg aaaaacgctg 3197341 gccgcgtctt taaagacagc gacaaattcg atgcaaatga ttctatccta aaagaccaaa 3197401 cacaagaatg gtcaggttca gccacattta catctgacgg aaaaatccgt ttattctaca 3197461 ctgatttctc cggtaaacat tacggcaaac aaacactgac aactgcacaa gttaacgtat 3197521 cagcatcaga cagctctttg aacatcaacg gtgtagagga ttataaatca atctttgacg 3197581 gtgacggaaa aacgtatcaa aatgtacagc agttcatcga tgaaggcaac tacagctcag 3197641 gcgacaacca tacgctgaga gatcctcact acgtagaaga taaaggccac aaatacttag 3197701 tatttgaagc aaacactgga actgaagatg gctaccaagg cgaagaatct ttatttaaca 3197761 aagcatacta tggcaaaagc acatcattct tccgtcaaga aagtcaaaaa cttctgcaaa 3197821 gcgataaaaa acgcacggct gagttagcaa acggcgctct cggtatgatt gagctaaacg 3197881 atgattacac actgaaaaaa gtgatgaaac cgctgattgc atctaacaca gtaacagatg 3197941 aaattgaacg cgcgaacgtc tttaaaatga acggcaaatg gtacctgttc actgactccc 3198001 gcggatcaaa aatgacgatt gacggcatta cgtctaacga tatttacatg cttggttatg 3198061 tttctaattc tttaactggc ccatacaagc cgctgaacaa aactggcctt gtgttaaaaa 3198121 tggatcttga tcctaacgat gtaaccttta cttactcaca cttcgctgta cctcaagcga 3198181 aaggaaacaa tgtcgtgatt acaagctata tgacaaacag aggattctac gcagacaaac 3198241 aatcaacgtt tgcgccaagc ttcctgctga acatcaaagg caagaaaaca tctgttgtca 3198301 aagacagcat ccttgaacaa ggacaattaa cagttaacaa ataaaaacgc aaaagaaaat 3198361 gccgatatcc tattggcatt ttcttttatt tcttatcaac ataaaggtga atcccatatg 3198421 aactatataa aagcaggcaa atggctaacc gtattcctaa cctttttagg aatattgctg 3198481 tttatcgact tatttccaaa agaagaacat gaccaaaaaa caaaatcaaa acagaagccg 3198541 gactaccggg cggcatatca ttttacgacg ccggataaat ggaaaaatga ccctcaaaaa 3198601 ccgatctatt ttgatggcaa gtatcattat ttctatctat ataaccggga ttacccaaaa 3198661 ggcaacggca cagaatggcg ccatgccgtc tcagaggatt tggtgcactg gaccgatgaa 3198721 ggcgtggcga ttccgaaata tacaaacccg gacggtgata tttggaccgg ttccgtcgtg 3198781 gtggataaag agaacacagc cggcttcggg aaaaatgcgc ttgtcgcgat tgtgacacag 3198841 ccctcagcca aagacaaaaa acaggaacaa tatttgtggt acagcacaga taagggaaaa 3198901 tcattcaaat tctacagtgg caaccccgtt atgcctaatc cgggcacaga cgatttcaga 3198961 gatccgaaag tcatatggga tgaccaagat aacaaatggg tcatggtcat ggctgaagga 3199021 tcaaaaatcg gcttttatga atccgataat cttaaggact ggcattacac aagcggattc 3199081 ttcccagaac aggcgggaat ggtggaatgt cccgacctct acatgatgcg ggcaagcgac 3199141 ggaacgaata agtgggttct cggtgccagc gcgaatggca aaccgtgggg caaaccaaat 3199201 acgtacgcct actggaccgg aagcttcgac ggaaaagaat tcaaagcgga tcagactgaa 3199261 gcccaatggc ttgactatgg cttcgactgg tatggcggtg tgacgttcga agacagcaaa 3199321 agcacagatc cattagaaaa gcggtatgcg cttgcctgga tgaacaattg ggattatgcc 3199381 aacaacaccc cgacaatgaa gaacggcttt aacggcacag attctgtcat acgcgaactc 3199441 cggctgaagg agcaggatgg aacatacagc ctcgtctcac agccgattga agctttggag 3199501 cagctgactg tttcaactga cgaaatagag gatcaggatg tgaacggatc aaaaacattg 3199561 tcgataacag gtgatacgta ccagcttgat acggatcttt cttggtcaga gctaaagaat 3199621 gcaggcgtca ggctcagaga atcagaagac caaaaacgcc atattgatgt cggcattttc 3199681 gctgaaggcg gctatgctta tgtcaataga gcagccacaa atcagcctga caaaagcaat 3199741 acctatgtcg aaagcaaagc tccttatgat gtaaacaaac gtaaggtgca tttgaaaata 3199801 cttgtcgata aaacaacgat agaagtattt gttggcgacg ggaaaaccgt tttttcaaat 3199861 gaagtcttcc caaagcctga agataaagga attacccttt attctgacgg cggcacagcc 3199921 tccttcaaaa atataacagt gaaacacttt gattcgattc atgaataaaa acaggggcgg 3199981 cgcaggctgc ccctgttttt ttattaggag cggtattctc tgttacatat tgggcattgt 3200041 aaggaatata aggctggttt caaaggagga agcgaatgtc taaacaagga aattttcaaa 3200101 aatcaatgtc gctgtttgat ctgattttga ttgggatggg agccatcttt ggatcagcgt 3200161 ggctgttcgc tgtcagtaat gtcgcttcaa aagcagggcc ctccggcgct ttttcctgga 3200221 tcctcggagg agccattatt ttgttaatcg ggcttgtata tgcggagctc ggagccgctc 3200281 tgccccgtac cggaggcatc attcgatacc ccgtttattc acatggccac cttgtcggct 3200341 acttaatttc gtttgtcacg attgtcgctt atacaagctt gatttcaatt gaagtgacag 3200401 ctgtgcgcca gtatgtggcc tattggtttc ccggcctgac cattaaaggg tctgattcgc 3200461 ctaccatttc cggctggatc ttgcagtttg ccctattatg cttgtttttc ctgctgaatt 3200521 attggagcgt caaaaccttc gctaaggcga atttcatcat atcgattttt aaatatattg 3200581 tgccgattac catcattatt gtgctgatct ttcattttca gccggagaat ttatccgttc 3200641 aaggatttgc accgtttgga tttacaggta ttcaggctgc catctcgaca ggcggcgtca 3200701 tgtttgcgta tctcggcctg catccgattg tatctgtagc aggtgaagtc caaaatccaa 3200761 aacgcaatat cccgatcgct ttaatcattt gcatcatcgt ttcaaccatc atttatactg 3200821 ttttgcaggt cacctttatt ggtgcaatcc cgacagaaac actgaaacat ggctggccgg 3200881 caattggccg ggagttctca ttgccgttta aggatattgc ggtcatgctc gggttaggct 3200941 ggcttgcaac gcttgtcatt ttagacgcca ttctgtctcc cggaggaaac gggaatatct 3201001 ttatgaatac gacatcccgc cttgtttacg cctgggcgcg taacggcaca ttatttggca 3201061 tattctcaaa ggtcaataaa gatacgggga caccccgcgc ttcgctttgg ctttcgtttg 3201121 ccctgtccat tttctggaca cttccctttc cttcgtggaa cgcgctcgtc aatgtctgtt 3201181 cagtcgcgct cattctttca tatgcgattg cacccatttc ttcagctgcg ctgagggtca 3201241 acgcgaagga cttaaacagg ccgttttatt taaagggaat gagcattatc gggccgcttt 3201301 cctttatatt tacagcgttt atcgtgtact ggtcaggatg gaaaacagtc tcctggctgc 3201361 tcggttcaca actcgtgatg tttttgatct atctctgttt cagcaaatat acgcctaaag 3201421 aagatgtcag ccttgctcag cagctgaaat cagcctggtg gcttatcggg ttttatatta 3201481 tgatgctgat cttttcctac atcggttctt tcggacatgg tttagggatt atcagcaatc 3201541 ccgtcgacct cattttagtc gcgatcggct cacttgcgat ttattactgg gcaaagtata 3201601 ccgggctccc aaaagccgcc attgattatg ataaataaag aagcaagagg ttttcttgct 3201661 tctttattct ttacaaacaa acatacacgc gataaaatga atgagagtca gtcattactg 3201721 gaggtgttcc tcatgccaaa acaaacatcg ggtaaatacg aaaaaatatt gcaggcggcc 3201781 atagaagtca tttctgaaaa aggcctcgac aaagcttcta tttctgatat tgtcaaaaag 3201841 gccggcactg cccaaggaac attctatttg tatttttcat ctaaaaatgc cctcataccg 3201901 gccattgcag aaaatctcct cacccataca cttgatcaaa tcaaaggtag gctccatggg 3201961 gacgaggatt tttggaccgt tttagatata ttaattgatg agacatttct cattacagaa 3202021 cgccataagg atattattgt cctctgttat tccgggcttg cgatcgacca ctccatggaa 3202081 aaatgggaga cgatctatca gccttattat tcctggcttg aaaaaatcat caacaaggcc 3202141 attgcaaacc atgaggtaac ggaaggaatc aattcaaaat ggacggccag aacgattatc 3202201 aacttggtcg agaatactgc ggaacgattc tatatcggat ttgaacaaga tgaaaatgtt 3202261 gaagtgtata aaaaggaaat tttcactttc ttaaaacgga gcttaggtac tgcttaaaaa 3202321 atgactgggt aacaccgctc attttttaat gccctaaaaa tgactgacgt tcattcataa 3202381 aatagagagg tgtttcattt gaattgggtt cttgttttta ttgcagggct tttagaggtt 3202441 gtttgggcct cttccctcaa acatgccgat tcgcttttgg attggatcat catttttatc 3202501 ttaatcgcgg tcagctttat cctgttgatc cgctcttatc aaaaaatccc gatggccgcg 3202561 gcgtacactg tgtttgtggg aatcggaacc gtcggaacat atctgactgg aattgttctg 3202621 ggcgaatcct tctcagcagc ccaaatgttc tttttagctt tattgctggc tggcatttta 3202681 ggaatgaaat tatttacgaa agaaagcaaa tctcagccgg gaggtgaaaa ataatggcat 3202741 ggtttttatt agtgattgcc ggcatagaag aaattatagc tgccattgcc atgaaatata 3202801 tagacggaac aagaaaaaaa tggccgatca ttgtgatgac tgttggattc ggcttatcct 3202861 tttactgcct gtcccaagcg atgatcgtcc tgcctgccgg agtcgcatat gccgtctgga 3202921 ctggcattgg aagcattggt gtttcggcgg tcgggctcat ctggtttaag gagcggtttc 3202981 agctttcaca ggtgatttca ctttgcctta tcctagccgg cgtcatcggc ctgcgtctta 3203041 cgtcatcttc ataaaatcaa ggcatataca gctgtatatg cctttgccat taagcttcgt 3203101 gatgtttttg aagatgaagc ggcggcggga tgagccagcc tttgtttttt agcagcctta 3203161 agtattttgc gccggttgcc gctttcgaca tatgaaattg cccaaacatc atggcaatat 3203221 cctcacgaat cgattgcccc atcattttgc tgcatgtcac aagacctgca gcattttctg 3203281 ctgccgcgga agccgccaca tccggatcga gaaaccgtgc accaggcgga atatcgttaa 3203341 gatctgctgt cggcggttca ggagaagccg gcggcagcgc caccccgttt tctttcagga 3203401 tcgtgctgac ctgtttgatt tcatcttggc atttctcaat agactcacga agcagcttct 3203461 tcaggtcgtc atcaccgaca tgattcaata gcatttggta attgccgacc attttattgc 3203521 ccgccatcac ataactccac aagccgaata cctcaccgta atgcatcggt tcatcctgcg 3203581 gatttccgct taaaataccc atgctcattc tcctcccata ttcaatattg cacatttcat 3203641 aacgtgccca agcggaggaa catttatgtt tcagcggaaa agatttatga aatgaaacaa 3203701 aacaaaaaag acaagagtgg caagttgcca aaccattgtc tttcctgttg tttgattgga 3203761 cgcactgaag ggattcgcac cccgacagac aagataccgg aaaccattca agtgcttttt 3203821 agtatgagtc attgattctg tctttaataa actttaacga gatggcggga tgctttgcgg 3203881 aaaacgaaat acattttcgg ggtcatattt cgcctttatt tctcgaagcc gcgcaaagtt 3203941 tgcgccataa tattcttttc cgaagttttc aatgttttga tctggaacat taacatatga 3204001 acctgctaca tatggttgca tcagctgacg cactctttca actgatgcaa gatttgaatc 3204061 ttcttgtgat ttatttttcc aactagccgt ccattccgta taaaataatg gatggcgcca 3204121 aaaaaaggca gtttcgtctt tagggactct gcttatagca ccaccccaat tgataaaaaa 3204181 gaaattggct tctgttccag tagcatcttc caaaaatttt ctcatgattg aaatgggttc 3204241 gtcagaccaa aaatcatgac cccatgccga ggagaattta acactctgat catttctgcc 3204301 agggatgggt tcgtcagggt ctaagaaatc tatagcatct ggatagtata atgttttgat 3204361 atctgcttct gttggagttc ccgcatgtaa taaaggtttt aataatcgaa tcaattcagt 3204421 tttcgaaccg aggaaaattc cttctgcatg acacaaacca tttattttgc tgtaaatttc 3204481 aaggtagcat cctaatcgtt catctacaaa cggagcccat ttctgccaag ctttaaatac 3204541 cgtttctaat tgttcccacg gccagataat attgaagacg gttgcagttt taggggcacg 3204601 atgaactttg aatgtatatt gggtattata tccaaagtta cctcctcctc cgcctctaga 3204661 agcccatagc aaatcctcat tgtgagattg atctgcgtga ataatccttc cttttgcatc 3204721 taccgttttc agcgcgagaa ggttatcact tataaggcca atcgatcgtg agagtacacc 3204781 aaatccgccg cccatcgtaa ttcccccgat tccaactgtt gggctatctc caaacggagc 3204841 cataaaaccg tctcgagcta atccctttac aagcgggcca acgggaatac cagtttgaac 3204901 ggttgcaata gcgttttctt catctaagaa aactttattc atgtcactca catcaataac 3204961 aattcctcca cttactactg aaaggttctt atctaaagca tggcgaccgc ttctgacacg 3205021 taagggcact ttattctcac gagcccattt aatggcatta cttacatcgt atgaattttg 3205081 cgcaaaaaca aagacaagag gatagacatc cacataaggg ttccaattct taatagcctc 3205141 tgtatagccg gggtctcctt tgaagattac acgccctgtc aactgtgttg atcccatata 3205201 ttatttcact cccaaagaaa ttcgattcag atactaaaat atgcaggagc tggataatcg 3205261 catagacaaa tgatctacga actataaata taatacgcta aggccttttt cgtcggtgag 3205321 gtctgctgag aaacattttt caaacaattt tgagcaaact tcctgtccaa tcctccaaca 3205381 agcgtttttt cttatcgttt ttaggagcag tgtccagttt ttttcggagt gaatattcgt 3205441 ttaggccaaa agaaaagaga gatgaagaag tgtttagtac cagaggtata catccataca 3205501 acagactcta gatcatcata tactgaatgt atgtagaaag gagacatcag ctttggcaaa 3205561 atatcggatt atgacctttg acggcggcgg taccttaggt gctttaagtt tacaactatt 3205621 aaacagattg gctaggcaaa acccgaagtt aattagtcga acccatgtat tttcgggaaa 3205681 ttcaatcggt tcatttactg cccttgcatt agcaagcgga agatctccga gggaaacact 3205741 tcagtatttt gaggatgaaa tcctacccgc attcagcatt tcccggccag gcggacctgt 3205801 tttcaaccaa caattaccct attccggttt tattaaagcg gtaagaaatt ttttcccagc 3205861 agatcttcaa cttatagatt taagaaaacg aattgttgtc ccatcattca aattatactc 3205921 tcaaaaactg gaccgttgga ctcctgtctt atttcacaat tttcccggct ctccctattt 3205981 aaatgaaaaa gtgagtgatg tcatactgcg gagcagcggt gctcccgcga cgcaacgcgc 3206041 ctatcaaaac tatgtggacg gatatgtagt agcaacgaat cccagtacag ccagtatcgc 3206101 gtttgcagtt ggtaaagcca acgtgccatt ggatcaaatt gcggtattgt ccatcggaac 3206161 aggtgaagcc ccgactcggt taagaagaga tacgagggga tggggaatgg taagtgcaga 3206221 taacatacgt cccgaaaatc tgaagaacct tcctccaaat tggggagtcc ttttggacag 3206281 gtcgcctaat gaacctttac tgccatttct tcagatgatt gctggcggta atgggtacta 3206341 tgaatccatg gtcagtgcga atcttctggg agatcgtttt ttccggttag atccgcggat 3206401 tccgaacttc tccaaaacgg accctgccgt cgttcccgct gtcattgaaa ttgcgaacaa 3206461 aacaaactta cagcctgcga atcaatttat agagaagaac tgggggagca aataattatt 3206521 tattttaaat caattctcgc ttatacaatt ttgtccgaga gaagattctc aaaataaata 3206581 caggcaatgg gtagaaccgg atttttttaa aggtttgtta atcacaagct aataagatga 3206641 atgaaaaaat caattcatac ttcttctttt gaaagtgagg gttcaaacta aagaatgtaa 3206701 ttgaaatgtt actctaaggt atgcaattcc ctttttcaca caaaaaaaga caagagcggc 3206761 aaatcgccaa acccttgtct ttcctgttgt tctattggac gcgctcggag ggattcgaac 3206821 ccccgacaga cgtggtaccg gaaaccaccg ctctatccaa ctgagctacg agcgcatata 3206881 gactgcgtta tgagaacgtc agcacaacta attatacgat aattcctttc aaataacaac 3206941 cctctatttc gagaggccgt tttttaaata gacaaagcat cttaattggc aatctgacat 3207001 acgatggttt gaacccctgt atttttgggg aaaatgggaa aaagagacga ctttgcatat 3207061 caggccagct ttttgtttga cctttattga ccaaaaatgt atcatgtaac tacatactta 3207121 cctaaaaggt gaaggaggag cattatgaat ttaataccta cagtcattga acaaacgaac 3207181 cgcggggaaa gagcgtatga catttattct cgtctattaa aggatcgtat catcatgctt 3207241 ggatctgcga ttgatgacaa cgttgcgaac tccatcgtgt cacagctttt attcttagca 3207301 gcagaagacc ctgaaaaaga aatttctctt tacatcaaca gcccgggcgg ctctattaca 3207361 gccggtatgg cgatctatga taccatgcag tttattaagc cgaaggtatc tacaatttgt 3207421 atcggtatgg ctgcgtcaat gggcgcgttc ctgcttgcag ccggcgaaaa aggcaaacgc 3207481 tatgcgcttc caaacagtga agtcatgatt caccagcctc ttggcggtgc gcaaggtcaa 3207541 gcgacagaaa ttgaaattgc tgcgaaacgc attctcttgc ttcgcgacaa attaaacaaa 3207601 gtcctagctg aacgtactgg ccagccgctt gaagtgatcg aacgcgacac agaccgtgat 3207661 aacttcaagt ctgctgaaga agcgcttgaa tacggcctga ttgacaaaat tttgactcac 3207721 acagaagaca aaaagtaata acacaacctg caagagctgc gtctcttgca ggtttttttc 3207781 atttcaagga attgactccc ttattctata ctgctcccat tcctcatgta acagctcaag 3207841 cgtcaaatca ctcgtctgcc tcacaaccag atcagcacca agcatcggct gtccttgacc 3207901 gacaccaacc gcaaacatcc ccgcagattt gattgcagaa atgcctgctt ctgcgtcttc 3207961 tattgccgcg caatcagcag gggaaacatc gagcatcgct gcagctgtta aaaagatgtc 3208021 aggatcaggc ttccccttcg caagagtcgt cggatcaaca atggcatgaa aatcatcgat 3208081 aattgccaag cgtcttaaaa tcttaggagc attgcgactt gaagatgcta acccgatttt 3208141 tatattttcg tttttcaatt gacatagaag cctgccaatc cccggtaaaa gatcttccgg 3208201 cgtcaatttg ctgatcagca tttgataatc gcgatttttc cgatgcataa gctcttgttt 3208261 ctccgcattt gtatactttg tttccgcccc gccaaagatc aatatgcttt caagtgactc 3208321 ttctctgctg attcctttta gcctttcatt catgtctctg tcaaaaggga tatcgatttg 3208381 ttctgcgatg tgcttccaag cgagaaaatg atattcagca gtatctgtta tcactccgtc 3208441 taaatcaaaa atgaccgctt tcatatacta atgcccatca cagcttcata aggtttgagg 3208501 ctaatactct ttaagtcagc ccgctcctgc ggatagtttg aaattagcac tttccaacgc 3208561 tcatgaatca gttctggagg cgcttcgaac agagcctttt cttccgataa attcacaacg 3208621 acaagaagct tttcccctcg atattctcga aggtaagaaa agacctgcgg atcattctcc 3208681 tgcaacagct gataatcgcc atatatcata atcttatatt gctttcgtaa ttgaatgagc 3208741 ttctgatagt aaaagaaaat cgaatcttga tcttccaaag actctttcac attgatatct 3208801 tgatagcggg aatttaccgg tatccacggg tctccggctg tgaatcccgc atgttttccg 3208861 gcatcccact gcatcggtgt tctcgcatga tcccttcctt ttatcatcac ggctttgaca 3208921 aactcttttt ctgacatcgt tttgttttcg acgactagtt cacgatatgc attctttatt 3208981 tcaagatcat catacatctc cagcggcata tcgctgttga ccatgccgat ttcttctccc 3209041 tggtaaataa acggcgttcc tttcatgccg tgcagaaccg ttgcaaatgc cttcgcacat 3209101 tccttacgca gtttcctgtc attgccccag cgggaaataa ccctcggctg gtcatggttc 3209161 tcaaaataaa gggtattcca gccgacattc attaacccgg tctgccacct tgtcatcgtc 3209221 ttttttaaag caatcaaatc aaacggcttg atctgccatt tcccatttgg cgagttttgt 3209281 tctttatcaa tatccatatg ttcaaatgta aagatcatat tcagctcttg cctgcttgca 3209341 tctgtgtact ttttcgcctc ttcaatatca gagccgtttg cctctccgac tgtcatgcag 3209401 tcgtaatgag aaagcacttc cctgttcatc tcttgaataa actcatgaag acgtgggccg 3209461 ttagagtgat aacggccgac aatatagctg cggctgtgat ccgtttcgta gtccggaaaa 3209521 tcggtgtatt tagaaataga gccaatcaca tccatccgcc agccgtcaac gcctctatcc 3209581 atccagaatc tcattacatc ataaacttcc cggcgaacgg cttcgttttc ccaatttaaa 3209641 tcaggctgtt ttttcgaaaa gtagtgcaaa taatactgcc ctgttccttc atcgtatgtc 3209701 cacgctgagc ctgaaaagat cgatccccaa ttattcggct ctgagccgtc cggtttagga 3209761 tctttccaaa gataataatc ccggtaagga ttgtccttcg acttgcggct ttcagcaaac 3209821 caagcatgct catctgatgt gtggttcacg accaaatcca tgacgatttt cattccgcgt 3209881 ttatggactt catcaatcag ctgaaacata tcttcatttg tcccaaactt ttcgtacatg 3209941 tttttgtaat cgctgatatc atatccgttg tcatcctgcg gggaatcaaa taccggggag 3210001 agccagatga catccgcccc gaggtttttg atgtaatcca gcttttgaat cacaccttgc 3210061 aaatctccga atccatctcc attggcatca taaaaactgc gcgggtaaat ttgataaacg 3210121 acagcttctt tccaccattc actcattagg cgttctcctt tcacatcgtc cctgtaggac 3210181 aaccggttcc tcataaacgt tcatgtgcag cggctcgcct tttacaagct caaaaataac 3210241 gcgcttttcg tcaaccgtca cattgattaa tcgatttcga taattgatgt tgaatgaata 3210301 ttcgtcccat tctttcggca aaaacggagc aaatgacagc gtctcattcg cggtgcgcat 3210361 gcctgcaaag ccatgaacga ttgccagcca gctacccgtc attgaagtaa tatgcaagcc 3210421 ttcttccgta tcatgattgt aattatcaag atcaagcctt gctgtgcgct tatataattc 3210481 gagcgctttc ttttccagct tgagttcggc tgcgagaatc gcatggacag agggcgatag 3210541 gcttgattca tgaacagtca tcggctcata aaattcaaaa tttcgccgtt tttcttccat 3210601 tgtaaaacgg tcattaaaaa gataaatgcc ttggagaaca tctgcctgct taataaaatt 3210661 ggagcggaga atcttgtccc atgaccaatt ctggtaaaga ggccgttccg ctggatctaa 3210721 ttcgtcaact gtttgcaggt ctttgtccaa gaacgtgtca tgctgaacga aaatttgcag 3210781 ttcttcacta aatggatagt acatgtgctg gatgatttct ctccagactt ccaattctac 3210841 ttcctgcaca tccagatggc ggcgtttctc cgctgagata ctttcgagac tttgtagagt 3210901 atactccaac gtccaagccg caatgacatt cgtataccaa ttgttgttaa cgttgttttc 3210961 gtattcattc ggccctgtga cgccatggat catatactta ttttttcgtt tcgagaagtg 3211021 aacacggtcg gcccaaaatc tgctgactgc cacaagtacg tctatcccgt attcttccat 3211081 atagttacgg tcgcctgtat aattgatata attgtagatc gcataacaga tcgcgccatt 3211141 gcggtgaatt tcttcaaagg tgatttccca ttcgttgtgg cattcatcac ctgtgaacgt 3211201 caccatcgga taaagtgccc ccttcatccc caattttgca gcgtttcgtt tggcagcctc 3211261 caactgatga tagcgataca aaagcaggtt tttcgtcacc tccggctcgg ctgtcgccaa 3211321 atacatcgga acggcgtacg cctcagtatc ccaatatgcg gcacctccat atttctcgcc 3211381 agtaaatcct ttcggcccga tattcaaacg ggcatcgccc ccgtaatatg tcgagaataa 3211441 ctgaaagata ttgtagcgga ttccttgttg aagctcctca tctcctttaa tctcaatgtc 3211501 cgcttttgcc catctttcct tccatcgatc agtgtgcctc cgttttgcat cttcatagcc 3211561 gttctctacc acatccgcca aaagctcctt ggctttcgat aaaagctctt cctcccgaaa 3211621 atcacgggaa gtcgtgacaa tcacaaactt tttcaatgat gccttcgttt gataactgta 3211681 gcgattctcg acatacattt cagtcgtttt aaagctttca tggacaaaac cctccgtctc 3211741 gtttgccatt gcggctaata ccgtgaagcg cggtgttcca aatggatttt cgatcgtttt 3211801 tgccgctaaa tggccgctgt gagaatcagc acctttcgct tcctcctgcc aaaactgttc 3211861 ttggtagtta gaatcttcat ttgccacatt tccatccagg taaggaacaa gcgtaatgac 3211921 agcatctccc gtcaagcact ccgcttcata atgaatcgca cagagttctt ttacagcaag 3211981 gctaagaaac cgctctgacc tgattctgac ggttttatct tgaatgcgga caacagcgct 3212041 tcgccgcaga atcccctctt tcatattgag ttctacctca aataattcga ttgggttttg 3212101 atggagatcg attttttcac cgtcaacata taggcctatg cccataaagt tcatcgcatt 3212161 gatcactttt ccgaaatatt ctggataccc gtttttccac cagcctactc gcgttttgtc 3212221 ggggaaccac acgcctgcaa tatatgtgcc ttggtgactg tcgcctgaat agccttcttc 3212281 aaaattccct ctgaccccca tatagccatt ggcaagagac gtcaggcttt ccagcagccg 3212341 tgtatgctcc ttattaaatg tatttgtttt gattttccat tcatcaatct caaataaccg 3212401 ctgatttatc atcatttcct cccgaatgta agtttccatt atcacggcgg gttttggtca 3212461 aatatctaaa tgcaaaagag atcatcaaag taacgccaca cgaatggatc atcaatacag 3212521 taatcaaatc aaaatgaacc atgccgatag cagctgccgc aaatgccggc agtgctgatg 3212581 cgcaaatcgc tatagaggcc gcttccttga atgatgcaat agagaccatg tttgatattt 3212641 ttgtgatcca gaggccacct gcaagaacaa acgttaacaa aagctggatc atagaaacca 3212701 ccgtatatgc cagcatcatg atcatcggct tatactgtgc caaccacaat gtatcgatca 3212761 agacctctac atcatggacg tttggtttct cgagcttaac gtccattttc gcatagccaa 3212821 cagaaaaccc cgtttcgttt tgatcggtga tcaccagttg atcaggttga aatatgatgg 3212881 cgttttcaaa tccagttact ttcaatcgcc cattttcacc gcttgtctca tattcatgct 3212941 tcatatcgac tgccatcaca ttctgcccat cttcaatcct ctcagagctc ttcccgcctg 3213001 ttagttttcc gttcctgatt tgaaaaccct gcaattgatc agcaaattga tcattaactc 3213061 cttgaatcgc tgacggcatg aaagatgaaa cgctgaagcg atccattttc acaaacgaaa 3213121 ccgctaacgg cgccattaag caggccgtta aaaacagaaa gagaaaagag agctgcagcc 3213181 agctgaaggt attcccatag cggcaaacac ctgatgggga tgcagccgcc ttcaggcagc 3213241 ggatgataaa gcttttattc tccagattct tcattggcat tacccctttg ttccgccggc 3213301 tgtcaaaccg gacacaaagt tcttttggag aaaaaagaat agaacgcata tcggcagtgc 3213361 ggctagtatg gcaccggctg caaatagagc tactttttgc tgctgcggat tagaaataaa 3213421 ggattgtaat cctacagcga tggtcagcct ttccggtgag cgaagcagaa atttcgtcag 3213481 caaatagtcg ccaaacggtg ccataaacgc ccaaagcgct tgtaccgcga gcattggctt 3213541 aacaagcggt agaacaattg aagcgaaaat cctcagatgt cccgctccgt caattcgcgc 3213601 ggcttcatca atttctctcg gcacagtatc aaaataacct ttcatcagcc acgtgttcat 3213661 cggaattccg ccgccgatat agatcgctgt taaaaaccag tattgatcga gtgcgcctat 3213721 tagcatcgcc aagacataaa aagcagtcag cgccgccatt gtcggcacca tttgaatgat 3213781 taaaaagaat atcaggctct tttttctgcc tgcaaaccga tagcggctgt acgagtaccc 3213841 ggcaagtgtc acaatcgtaa cctgcaaaac catgaccgat agcgcgatga caagtgtatt 3213901 gctgtaccaa ttgagataaa gcgtttcgtc aaatagccgc ttaaaatgat ccaatgtcca 3213961 agaacccgaa aaatcgagct gaaaagccgc cgaattcccc acacggaagg ctgatgatgc 3214021 cgtaatcagc aacggatata taatgacaat acttaaaagc gtcaaaaata aatacgtaca 3214081 gattttatta agcattctgg cagtgctcgc gttcacctac ataacctcct cattgccaaa 3214141 agcattcgat tttttgaaag caatcagtga aattccaatg acaatgaaag aaattaacag 3214201 tgtcacagcc gccgcaacgg aatattgggg tgatgtgcct gttgtcagtt tataaatcca 3214261 cgaaattaag atatcggtcg atccggcccc ggctcccgca ctgcctggcc ctccctcatt 3214321 aaataaatag atgatcgaga aattattgaa attaaacgta tactgagtaa tcatcacggg 3214381 tgctgtggca aataaaatca tcgggaatgt aatatgccga aaacgctgaa taaaagtggc 3214441 cccgtcaatc tttgccgctt catacaattc acctggaatc gcctgaagca ctcccgttac 3214501 catgacatat atatatggaa agccgagcca cgtttgaatc ataatgaggg ctgtctttgt 3214561 ccagaaagga tcggtcttcc acgcgatcgc aggcagctcg acaaacggca ggtgattgaa 3214621 taatggtatc acctgtgcat tcaccgctcc tatgctgtcg ttaaacatgt tggaaaaact 3214681 catgattgta ataaacgccg gaacagccca tggaaataag aaaatcattc gaaatatccg 3214741 cttgcctttt ataaaatcct gattgacgaa aagtgccgtc acaataccta aaatgatttg 3214801 cagcgttgtt gcacagattg tccagataac cgtccagccc agtacattca caaatgtttc 3214861 acgataggag ccaaggaaaa aaatatttaa gaaattttta aacccgaccc agtcaatcag 3214921 acgattaggc ggaatatgat aaaaatcata gtttgttaat gcaacaaaca gagtcaccaa 3214981 aaccggaaaa ataatcacaa acaccatcat gatatatgcc ggcagtgtaa atagatacgg 3215041 aaaaccttta tcgcccgcat gacagatcat atccttggct gttgtattga cttccaaacc 3215101 cgccgctttc atagcggcgg tcttacgtga atcatgaata ttaaagatat agaacatgag 3215161 gaaaatcatt gtcacgatca attgcagcgt gccttcaatc agcataaaca gcgagtgatc 3215221 ttcaccggga acacttccca atgtcatcaa tccggttagc gcctgtatac cgaaaacgca 3215281 taattcaaaa gcaaacaagc ctgtgatggc aagaaataag agcccctttg acaactgctg 3215341 attcgcaatc tgcccaagtc ctggaatgat cgataaaagc cctgcctttc gtttttgctt 3215401 tgtaagtgtg tgatgtttat tcatttttcc gccctctatt cttccggacg ctatcccgcc 3215461 gttttatttc acatactttt ctttaatatt ttcctttatg acgtttacag catcattcgc 3215521 tgatgtttgt gtcgattttt ttcctgaagc tgcatcaaaa attaaacttt ccgctcctgt 3215581 ccatacttca gccatttccg gaatatttgg agtcggcgtt gctgtttcat attgtttaat 3215641 cacagctgac gtcagttcat tcttttgctc atcggctttc ttccttgcag ccgtgttggc 3215701 cggaacttcg tttgtatcct cataaaaagc gtaagcattg gcatcatttg cagcatactc 3215761 aagccatttt tcagccagct cgggctcttt tgtatatttc gaggcaaccc agcccttccc 3215821 gccagcaaaa ggggcgtatt cttctccatt tggcaatgtc ggaatgggag ccgctccgta 3215881 gttcaattta gcctctttat agttggcagc tgaccaagga ccgccaatga tcgcagccgc 3215941 tttgccttct aaaaacatct gctgaataaa gtcgtctgcg cttgaattgt cttgcattcc 3216001 tttcggccaa tatgtctcaa accatttctc cgcatatttc accgcttcta cagccccttt 3216061 attgttcagg ccgatgtccc cggaatctgt gccgtttttt ccaaacacat atccgccgta 3216121 tccagccaat aagccgtacg acatataaaa gtcagtccat tttgctaaaa atccggttga 3216181 ttttcctttt tccgaagcaa acgcgaatcg aggatcttcc gttaactttt caaggtcttt 3216241 aaatgttttt ggcgctgttt ttaaaagatc tttgttgtaa tacaaaataa gtgtctcaat 3216301 gactagcggc attccgtaca ctttgccgtc aactgtcacc tgctgcattt ctttatcacc 3216361 aaagcttttt gtgttagatg gcttaatatc aagtaaatgt ccttgttgtc ccaaaccgcc 3216421 gatccggtca tatgcagcaa gcataacatc aggcgcatta cccgccgggc catcaagagg 3216481 aagcgcttct aactgttcga acatttgctt ttcaacaatt tttactgtga catcattttc 3216541 tttttcgaac tttgttttta tgctttcaat gtattcttta tacgtttctt cgacagacac 3216601 agtcagcacc tttttgccat cagagcttgc tggatttttt gaacttgagc aggcggcaag 3216661 gccgattgcc aggaatgatg ccgccaatat ggcgaacccc ttttttaaaa gaaccatctc 3216721 ttttcctcct tctatttacg aaactataac aattgtattg tcctatagaa agcggttaca 3216781 acaactttcg atttgttacc gataacagaa tgttatacag gggcggcagc actcaaaatc 3216841 aaaaattctc ccggctgaac ggcaatgaca tcgtgatgct gtagcggctg ctctgtccat 3216901 gcatcacaga ttttcttatt cctatcaata ttcaactctc gtaaactgac gtgttgaacc 3216961 acattccctt gattaaagaa ataaatcagt attttttcat caagagtccg cgaaaagcta 3217021 atgaaatcat ttttgtcgtc cagcagattc cactcaagat gtccttcagt caataaagtg 3217081 ttttcctgct tgcgtaaagc aattaaccgt ttcataaatt gcagcatgtc ttggttttgc 3217141 ttctcttttt cccaaaccat acatttccgg cataatggat cattttcgcc gttcagcccg 3217201 atttccgttc cgtaataaat gcatggtgag cctgtctggg caaacataaa ggccagcaac 3217261 gcgcgtgctt tcttctcatc attgcggcat ctggtcaaaa ggcgctttgt atcatggcta 3217321 tccagtaaat taaacatcac ctcattggcc tgcttcattc cattcatcaa atgtgcattg 3217381 acacggtgag ccatacgtga agctgagatc gtctggtcag caaagtattc aatcataggc 3217441 tctgtaaaag ggtaattcat cgccgcatga aattcatccc ctctaagcca gggttcggca 3217501 gaatgccaga tctcacctaa aatataaaca tcaggctttt cagtagatac agcctgccta 3217561 aatgtcttcc aaaaaacgtg atccacttca tttgcgacat ccaaacgcca gccgtcaatg 3217621 tcaaattcgc gaatccagta caaagcaata tcaagcaaat atttctgcac ctcgggatta 3217681 gccgtgttta gcttcggcat atcagctgta aaagcaaatc tgtcataatt gtcgtctgtg 3217741 acgggaaaag agtgaatatg gaaccagtcc ttatagcggg attgatctcc gtttttgacg 3217801 acatcctgcc attgcggaga cgcgcttcct atatggttaa aaaccgcatc aagcataatt 3217861 ctcatccccc gctgatgcag ctggctgacc aatgtacgaa aaagctcagg atccccgaaa 3217921 tgcggatcaa tagaaaagta atccagcgtg tcgtatttat gattagaagg cgcggaaaag 3217981 atcggtgtca gataaatgcc gttcacccct aaatcctcta aataatcaag cttgtcaaca 3218041 attccttgta aatcccctcc aaaaaaatca ttgacgtccg ggtccttgct cccccacggc 3218101 aatgcattct tcggtgacaa gtcttctctt ccatttgcaa aacgctccgg aaaaatttga 3218161 taccaaaccg ttgacttgac ccattcaggc gcttgaaatg tatcagcctc gtgaacaaac 3218221 ggaaatttaa agtaataatg aatcgtttcc agtgtttttt cgttataagg gcatacaccc 3218281 gaacttccga aaaagatgtc ttcatgatcg tctgttacaa caaacgcata ttgtaaacgc 3218341 ctaaatggcg gcaccacttc agcaaaccaa tagtcatgca tttctgtagc agcaattttc 3218401 ctcatcggct gctcgtttgc cgaccatttg ccgtcgttgt actcataggg atcaccccaa 3218461 atgaatcgaa tgtgatctgc atcacctttt ttcgtccgaa tcttgatatg cacagtccgc 3218521 ccatcataag aataagcatc tgtgctgaat ggctggtgat gaatcgctgc atattccatc 3218581 atgtttcccc ctttgatttc cgttttattg aagccggctc atagtttgaa agtatcatga 3218641 tgaaattgtg ggaacaatcc ttttcaccct gttaccgata acagaataag gcgcttacag 3218701 cgttgattct cgtacaatta actctggttc aaaaaataga cttccttgtg cagcgccgtc 3218761 ttcattcatt tttttcagca acattttcgc acaggcttcc cccatttcaa caacaggctg 3218821 tctgaccgta gtcaagcgcg gcgaggagat gcgatcaaga aacacaccgt cattcccggt 3218881 aaccgcaacg tcttctggaa ttcgctttcc aagggattgc gccgcacgaa tgacgccgag 3218941 cgcgattcga tcagatgcgc agacaaatgc ggcctgattg tccatggatt tcagcagttc 3219001 tcttgcaagg cattcacttt tcttagaact gttgtcgatc cgaaacatat tcgatttttt 3219061 aaagctttta ttcatcgccc gtatataccc ctgttctctt gcacgttcga aaggctcatc 3219121 taaatcaatg ccaaaaaaga caacttcccg ctcccccagc cccataacat ggcgggttgc 3219181 cataaaagtg cctttctcgt tattcacatc gataaagtca tagcccattt cattttgtcc 3219241 aaatacgacg agcggcttct caaaagcttt tattacacct tcaaaatcgt tctttctcaa 3219301 gccggtggca ataatgccgt cacattggcc aatattaaga gaatttcttg tcacaagctg 3219361 gagagcatag tgattgcgat ccagctccct gctgattcct gtcagcaggt tcatgtaata 3219421 tggttctgtc gtatccattt cctcaagtat caatagtttc acaacctgtg ttctgttttg 3219481 cacgagcgct ctcgccgcat aattagggat gtaattcagc tctttcatcg cagaatgaac 3219541 aagctttttc aattcatccg tcaccgtctc agggtgattg atcactcgtg ataccgtcat 3219601 tttcgaaaca tttgcttttt tcgccacatc tgacaatgtt gccattttca tcccctcctt 3219661 atctgtgctt attatccaaa ctagtgataa agtcctctat tactgctaaa tatacgatgc 3219721 aggccaaaga gaaataaaaa agagatttcc cttaaggaaa cctcactttg ttaaaaacac 3219781 tcgatttttc atggattcat acgctaggtg gcagactcat tctctccact tccatcagaa 3219841 aatctctttt ttaaatttct gtccactttt tttctaaaat cggataagaa taattttgca 3219901 tttgctcaat taactcatcc ggccgtgacg agctgtgaat cagttttagg tgcgattcgt 3219961 tagaaaaccc ttcttgaatg ctgtatttca ccattttcat cattggttca aaatatccgt 3220021 ttacattgta cagtccaatt ggcttttggt ggatgccgat ctgtgcccag cacagcactt 3220081 caaataattc ttcatatgta ccgaagccgc ccggcatcga gataaagccg tccgccagct 3220141 cgctcatttt agcctttcgt tcatgcatcc cgtttacttc aatcagctca gtcagattct 3220201 gatggacaac ctccccgctg aacaaaccgc tcggcatgac cccgattgca gttccgccgt 3220261 tttccataat cgcgtcagca atcgtgccca tcaagcctac gcgggagccc ccatagacaa 3220321 ggccgattcc ctgctcagcc atatacacgc caagctctgc cgcttttctt ttatacgctt 3220381 catttccccc agggtttgat cccgcaaata cacaaatggt tttcatcttg tcatctccgc 3220441 atctatatat cgtgttaaac attcaaaaac acactatata ttgtcccatc ttcatgtgat 3220501 aatatcaata tgaaatacat aaagaatgca ggagtgatga ggttgcagct ggctgatgca 3220561 gaaaaatgga tgaaagagtt ttacgaaaaa agaggctgga cagaatacgg accttttatt 3220621 cgcgtcggct ttttaatgga ggaagccgga gaactggccc gggctgtcag ggcgtatgaa 3220681 atcggcagag accggccgga tgagaaagaa tcgtcacgcg ctgagcaaaa acaagaattg 3220741 attgaagaaa tgggagatgt catcggaaat atcgccattc ttgctgatat gtatggtgtc 3220801 tctttagaag acgtcatgaa ggcccaccaa gaaaaactga caaaacgatt tgagcatgca 3220861 taaaaaagcg gccgcgatgg ccgctttttt taacctgtga tttcatcatg gtgatcaaag 3220921 aaatgctgct ttcctatttt gtgaaaaagg cctgttttat gcagtagctc cttcggctgc 3220981 gattgcaatc ctacaatcat cagctttcca ttgtggcgtt taattcgatt cataatgttc 3221041 ccaagcaccg cttcagctga cgtatccata tagtgcacct tattcatgag cagaataagg 3221101 gttttcggtt ttttctgtac atgctccagc aatgacgatt caagggaatc aattgatccg 3221161 aaaaacagcg gcccttctat ggcatacatg ctgacagatg gatcttctct cttcgccaga 3221221 acaggatgcg tttcctgatt gtggatgcgg gtcgcttcgc tcattcttct gataaagaac 3221281 acgaatgcaa gcagcaatcc ggttgccaca ccgatgatta agtcaaacag aaccgtaagg 3221341 gcgaaggtcg ccgccaaaat aaaggaatca gcatttttca gtctcagcat gtttgcgact 3221401 tccttgcgct cactcatatt ccatgcgacc accatgagaa tcggtgccat actggcgagc 3221461 ggcacatggg acgcataagg cgcaaataca agcaggacaa ggagaacgac tacgccgtga 3221521 acgacgccgg aaactgggga aaccgctccg ttttttatat tggtcgccgt tctcgcaatc 3221581 gctcctgtag ccgggattcc gccaaacagg ggcgctgcca tattcgcaat cccctggccg 3221641 acaagctcct tgttgctgtc atgctttgag cccttcatgt tatcagcgac cattgcggac 3221701 aaaatcgact caagtcctcc aagaagcgcg atgacaagcg cagccggaaa cagcataacc 3221761 attttatcca aagtaagctc aggaaactga aattccggca aatggcgggg gatttctcca 3221821 taagttgacc cgatcgttgc catgcggtca gggaaaaaga caaccgcgac cactgtggaa 3221881 ataagaagcg ccaacaaagc gcccggcact ttaggcatca ccttggcgga tacaagcaaa 3221941 atgacgagcc cgatcacagc tgtcaaaatg gcatacacgt taaaggtgcc gagctgctgc 3222001 acaatttcaa acatgttgtg atgaaagttc tcatgttttt caacatttct caatccgaga 3222061 aaattagcga tttgttccgt aaagatcagc acggcaattc cggctgtaaa accgacgata 3222121 acgggtttgg gcacgaattt cattattttt ccgagcttaa acagcccaaa cagtaccagc 3222181 atcactcctg ccataaaccc cgcaatcagc agattttcca agccgtactg catgataatg 3222241 ccgaataaaa tcgggacaaa ggcgcccgtc ggaccgccaa tctgatattt tgatcctcca 3222301 aacaaagaaa tacaaatccc tgctataaca acagtgtata gcccatattc aggctcgact 3222361 cccgaggcaa tggcaaacgc cattcctaaa ggaattgcca cgacacctac tacgatacct 3222421 gcaatcaagt ctttctgaaa tttctgcaaa ttgtatccct tgaatctccc tgagaatcgc 3222481 atattttgtt ataacctccc ttatgagtga ttgtttataa gctcagtttc ataaccgtta 3222541 atgaccacat caagttttcc tgtttcaggg tgaatgacaa gcccgtgaac cggcactttt 3222601 ttcggaagca gcggatggtt cttaatcatg ttcacactgt gggaaacgct ttcttccacg 3222661 ctgtgaaaac cagtcagcca cgttttcaaa tcgagtccgg cactcgtcag caaattcagg 3222721 cagctatcct ccaccccgcg ttcctttgct ttctcaagaa tcgaggacgc attcagccct 3222781 gacattccgc attcatgatg gccgacaatg catacctctt cagcctgcaa ttcataaatc 3222841 gcgaccagta tgcttcgcat cacgcttcca aatgggtgag aaacgatggc tcccgcgttt 3222901 tttacaattt tagcatcacc gtttttaagc cccattgctt gcggaagaag ttctgtaagc 3222961 cttgtatcca tacaggtgac aatgacgagc tttttcgaag gaaactttgt cgttttgtac 3223021 ggttcatact tcttctcact gacaaaccgc tgattgtgtt ccaaaattga tgttaaagaa 3223081 accatttgat tcatctccca tccatatgat tttgcaagcc ttcttaccca gcttacagta 3223141 aggaattata gcataggaat aagccaagaa aaggttttca aaaaaagaca ctataattgg 3223201 actgtagaat caaaacataa acatttatat ctttcaaaga taataaaatt tatatttaat 3223261 gcatcctata atccggctgc agttcgtata tcgatgattt gtctgacaaa aaatatgggt 3223321 gaattctgat aattaaaaaa cttttttaag cagatttagc tgttcgatct tcattttaag 3223381 ttcaaaagaa ccagaaatta aaaaaacgca gctatatttt taacatctat ttattttcga 3223441 tataatgaat tagacaacag ccataaaggg ggagccttgt tgaaaccatt tgtatttatc 3223501 acaaaaccga ttcctgaaga gattgaagca ttcatcggtg aacattgccg ttatgaagta 3223561 tggcaggagg atacgcttcc gagtgacgtg ctatttgaaa aattaaaaga agcggagggg 3223621 cttttaacat cagggacgtc cggaccgtca atcaatcgtg agttgctgga acacgcgcct 3223681 aagctcaaag tggtcagcaa ccaatcagta ggctacgata acttcgatat agaagcaatg 3223741 aaagaaagag gagtcgtcgg gactcataca ccttatacac tggatgacac agttgcagat 3223801 ctggcttttt cactgattct gtcttccgcc agacgtgttg ccgaactgga ccgttttgtc 3223861 agagcaggaa aatggggaac cgtggaagag gaagcgcttt tcggaattga tgttcatcat 3223921 caaacgttag gcattatcgg catgggcaga attggagaac aagcagcgag acgcgccaaa 3223981 tttggttttg atatggaagt gctttatcat aaccgacatc gcaaacaaga aacagaagac 3224041 agcatcggcg ttaagtatgc agagcttgat acattgctgg agcaatctga ttttattctt 3224101 ctcattacgc cgctgactga tgaaacctat cacatgatag gagaacgcga atttaagttg 3224161 atgaagaatt cagcaatttt cgtcaatatt tcccggggaa agacagttga tgaaaaagca 3224221 ctgattcgcg ctcttcagga aggctggatc aggggagccg gcttagatgt atacgaaaaa 3224281 gagcctgtca cccaagataa tccgctcctg cagctggata atgtcacgct gcttcctcat 3224341 atcggttcag caacagctaa agtgcgcttc aacatgtgca aacaggccgc cgaaaatatg 3224401 ctcgcagcga tccaagggca aacaccgaaa aatcttacaa gagaatttca ataaatcaaa 3224461 aatccggtct gataacagac cggatttcat attacatacg ctgaagaaca gcacgcttat 3224521 aaatatgacg ggtgacgata taataaagag cctggaatac aaaataaatg aagatgacaa 3224581 ttacggcctc aagaaataaa ttggaattca gcatattact taacgctgca tacgcaaagc 3224641 ccgcgtgaat cgtacctgcg ataaatggga tgaagaataa aaatcctatt tgctttccaa 3224701 ggatcgagtg aatctctttg tccgtaaccc ctatcctctt taacgctaac acctgcactc 3224761 ccgtatcttc tatttccgta aacatccgca aatacagcat gcttccttgc acgataaaaa 3224821 acagcacgct gacaaacaga ccaataaaca gcattaatgc aactccctgc ttcacaattt 3224881 gataactagg agcacgtgtt tgaaaatcag atgtatgttc tttcggcacc atgttttcaa 3224941 gcttttcaga gacatccacc gtctcctgcc aatgctcaag ctcataacct accattctca 3225001 tctgttcctt cagcggcaca tcctgtgaca gactgtcaaa gctcttttcg ctgacaacca 3225061 ataaacggct gactccatcg acagacatca atatcccttt gttttgctgc tttttcatga 3225121 cataggaaag ggtttttcct gacttcatat gaaatgctgc tgtttcccct tctccaaatg 3225181 tgtctttcac catcatttga aaagaaacat taataaatgc ttcattttct tgtaaatgaa 3225241 taactgggaa ccctttttcc tttgcgactt gattatagac tttttctgaa atcagcaaag 3225301 cttcagcttc catcttctta tttccatacg gcaagtctga ctgaaaagtg acaggaatcc 3225361 ctgtggcatc caccttatac gtgataacag catgagcttt tttcaatgta ttctcagccg 3225421 tctcaggctt catgacctga aagcgggaag catccttttc cacccaggaa acagactgag 3225481 gaatgctttg ctcctcctgc ctttgtaaat cggaataaaa catatagatg acacctgtag 3225541 ctgttagtat gaccgctgta atgacagagg ttaaaaacag catgcgtgca tgatccttca 3225601 gcctgaatat catgttggaa cgcacaatga tatttgtgcc tttgtagaag ctgtgtttct 3225661 ttcggtacag catgcggaaa aatgccacac tgctttgggt aaaaaagaaa tacgtgccaa 3225721 ttaacactaa aatcaaaatt ggaaaaaccc gaaacatcat gtcaattgca ttggctgttg 3225781 cagatagata ataaccgctg ccaagacata gcaaagacaa tacagtgagc catttcgaat 3225841 aaactggcaa acttttcggc tttttggctg atttaatcag ttcaatgatt tccagcttcc 3225901 gaatccgtcc cagtgataaa atgagcagcg tctgaaacag gatgagaaag ccggcaattg 3225961 tcatcacaaa cgctttcggc acaatggcaa acgaaatcgg caccttcacg ctgagcatcc 3226021 atgtcatgat cataaaaaac agttttgaaa ataacaggcc tgctccaatg ccggccgcaa 3226081 tcgccgcaag agaaataagt gactgctcat aataaatcat cttgcgaagc tgctgctttg 3226141 atgtgccaaa cagtgtcagc agcccaaact ctttctttct tgcctgcaaa aacgctgaat 3226201 tggaatatgt gatgaaaaat atacaaaaca caatgatgac gacaagagct gcgctcaagc 3226261 atgttttgac aaggcttcct ccatatatat tgtcttcatt gacatcagga tgaaaaataa 3226321 atgatgtgaa gacaaaaaac accgaaacgg caaacacaca gcttaaaaag taggccacat 3226381 accgttgcag attcccaaga atgtttttac gggcgatagt tctcaaattc atgaaaatcg 3226441 cctcccaaca cactcaaggt atccaatata ctttgataaa acacctgcct gtttgttcct 3226501 ctgtgaatct ctgaaaagaa acgtccgtct ttaataaaaa caatccgttt acagaaactt 3226561 gctgctgtgg catcatgcgt aaccaacaaa atcgtcgctt ccttttcctc attcagctga 3226621 gccagtgtgt tcatcacttg ctttgccgat tttgagtcga ggtttcctgt cggttcatcg 3226681 gcaagaatga gcgccggatt gtgaataatc gctctggcac aagctgcccg ctgctgctgt 3226741 ccgcccgaca cctcatatgt gcggtgatcg agaatatgct ttatttgcag cgtatccgcc 3226801 agttcatcca atcgagcttc catttctctc agctttacct tatccaatgc gagcggcaag 3226861 agaatatttt cacgaatcgt cagcgtatca agcagattaa aatcctgaaa gacgaagccg 3226921 agttctcttc tgcgaaacaa agccagctct tggtccttta acgttttcgg ctgaatgccg 3226981 ttgatcatca tctcgccctg ggtcggctta tcaatggtag ccagcaaatt caaaagcgtg 3227041 gtttttccgc ttcccgacgg ccccataatc ccgacaaatt ctccttttga cacactgaga 3227101 tcaaaggcgc tgagcgcttg gtatgatatt gttcctttat ttgaatagta tgttttcgat 3227161 aggttcgttg tttgcaacac gttcatgttc tgctcctcct ttttctttat tataaaaagg 3227221 aagtcagcat cctcccatcg aactttcttg caattccgct ccccaatctt acaatgctgt 3227281 cacattcacg agggtgtcac ttgaaaacac gatggtcatc acagtgccag ccccttcttt 3227341 tgattccgca tacagcttat ggccgagacg gctgcacacc tgttttgcta aataaaggcc 3227401 cattccagtt gcctctttca tggttcgtcc gttttctccg gtaaaaaacg cgtcaaaaat 3227461 ccgcggcaga tcctgcggcg gtatgccgat tccttcgtcg gcaaccgaca agcgcgtctc 3227521 atgtccctgt gtttcaatcc ggattgtaat agggtctccc acaccttgct ttgaatattt 3227581 taaggcgttg aaaaggattt gctcaacaac aaaggaaagc cacttttgat cactggaaat 3227641 ctgaacggca tttggcggca catgtaatgt tggaaaaagg cgccgcttga taaactgacg 3227701 tttttcctga ttgatcagtg aacgaaccat ttctgccaaa tcaaaggttt gcggctttac 3227761 atcaaatgca aattcctcca gccgggccgt ttgcagcatc atatcaagac cgtggcgaaa 3227821 tctctcattc tcatcctcca gctcctctaa aaacgtcgga aaagaggatg aggttccgtt 3227881 ttttccttcc tgaatcatta aggatatgac agataccggt gttttcatat ggtggaccca 3227941 ttggttggtg aaggtgtaat gctgtttttg ctgattgata tattgtgaga gcctgctttc 3228001 gtattgctgc ccgagtgcgt tgatcatctt cgtccaaagc gcttgctctc ctgttcttgg 3228061 ctttctggct ttcaaagact gtccgatgtc attcgaagaa gaggcttgtt ctgcaagctt 3228121 tttaacatat gtgagaaagg aaaattgccg aacataatca gcagcaaaac ctgcggctaa 3228181 aagagtaccg ggcaaaatcc atatgtacat catattttct ttggaaggtt ctgcgccgct 3228241 ctctacaatg cttaaatacg caatcagcat ggcggaccct atccctaata atgaaaatag 3228301 aataatggct aagcggtcga tgagataagt ctttaacatt ccgcttcatc cttccgattg 3228361 acttgaaatt gataaccttg tcctctgatt gtggaaatgc aatctgtcag tcctgcattc 3228421 tccagttttc tccgcagccg attgacattg accgttaacg tattgtcatc gacaaaatca 3228481 acgtcatccc ataacgcctc caatagttca tcacgagaga caattttttt atgctccctc 3228541 acaaaaatcg agagaagctg gaattctttt tgggaaaaca aaatccggac gctgttccat 3228601 tcggcctcat tctgatcagg ataaatcgtc agcccgccaa gctccactat tctagattcc 3228661 tgcggcaaag agggcgaata ttcaccatat gtgcggcgca ggacgctttt gattttggcc 3228721 atcactacct ctagatggaa cggctttgtg atataatcat cgccgccatt ttcaatcgcc 3228781 attacctgat tcagctcatc ggtccgtgcc gatataaaga taatcggcgc attggaaatg 3228841 gtacggattt gcctgcacca ataaaacccg tcaaaaaaag gcaggttgat atcaagcagc 3228901 acaagatcag gcttcatttc tgcaaattcc aattttatat cattcagctg ttcagcaatt 3228961 ttcacttcat atccgtattt ttgaagatga ccgcccagca aagaagcaat ccgctcatca 3229021 tcttccacaa gcaaaatccg atacacgttg atccccctta tatgtacatc acgatgattt 3229081 ttctagaaga ttccaaaatt attatagcat gtgcggaata gtaaatcggt ctttttcttt 3229141 ttgttatgat agaatgataa aggtaaaatt ttcataatag gcaggtgtcg tgatgaagaa 3229201 aatcatgctg tttctggcaa tgacgtcaat tctttcagca tgtcagccca actataccgg 3229261 gaaatacata gaaattgggg atacactaac tgactatacc aaagagtgct ttaaagagaa 3229321 tgaaattcct tataaatacg aaaagggaaa actgtatatc ccagaagacg catttgatac 3229381 agcaatctac acttgttcat aagaaaaagc ttgcagataa cctgcaagct tttcacgtta 3229441 caaaaaatga gtatttaatt tctcttcaaa tcctgaaggg ccgatgtcgc ttttttgaat 3229501 gttaccgccg ttttcataaa tcgtaaaatg gcgctctgac atgaccatcc ttccgctcgg 3229561 cgtcagcttt gaggcaagca gggatttgtt aaaaggagat ttttcatgag agtgaatgat 3229621 gtccttcatg ttatctaaat caccgagatc actctcttca agggtaaagg cgtacccaat 3229681 ttgccagcct tctcctttgt ccatcagcag aacatagctg cccttttctg tctcttcctt 3229741 tttgattcgg aatgacccga ctggtgactg taccgtttct ccggaaagcg gtatcggctg 3229801 gagcgccagg ttgatgccga agccgatatc aacgaggtaa tcgccgtttt ccgcagacag 3229861 ccatacagca gcatgcgtcc cttctagtgc ccatccctct tgatcgcctg cataaaccgt 3229921 tcctcgaatg agcttcacat gaaacccggc ctcacgcaag acaaaataaa ggaaaccatt 3229981 tagatcgtag cataggccgc cgtgctgatc tttgagcaga cgtcgccata gctcttcttt 3230041 tgtgatctta taattctctt ttgcaagtac ggcacggttt tcgaatggaa aacggtatgc 3230101 cattgcttta agaaaaaggg gaagatcgcc gaagctgaca tggtctttct cccagccgat 3230161 tttctgaaag cagtctttta gaaagtcact catttttatc acctaaactt cttcttgaac 3230221 gtaagcagcc agcttctcca gcgcctcttg ttcatcttct ccctgggcaa tcaaggtaac 3230281 ctcagtgcct gtgcttaccg caaggctcat cagccccatg atgcttttgg cgtttacttt 3230341 tttcccatcc ttctcaagaa acacatctga cgtaaaccgg tttgcttctt gtacaaacaa 3230401 agcagcagga cgtgcttgca gtcctgtctt taatcgaact tccactttct gttgaaccat 3230461 aagatctccc cttttcttta cggttatttt aaagtgacgg tttgccctgt ccgcagctgt 3230521 tctgcgattt cgtcaagttt tctcagcctg tgattgatcc ctgatttgct gattttcccg 3230581 cttgctacca tttcccctag ctctttcagc gtcacttcct gataatcaat ccgcagctgc 3230641 gcaatttccc gaagtttttc aggcagcgcc tccaggccga ttctttcatc gatgtattta 3230701 atattttcca cctgtctcag cgatgcgccg atcgttttgt ttaagttggc tgtttcacaa 3230761 ttgacgaggc ggttgaccga atttctcatg tcccgaacga ttctgacatc ctcaaatcgc 3230821 agaagcgaat tgtgagcgcc aattacgttc agaaactctg taatcttttc agcctctttt 3230881 aaataggtaa tatagccttt tttccgttca agcgttttgc tgtttaactg aaactcattt 3230941 aacaggtcac ataatgaatc gttatgctcc ttataaagag agaagatttc taaatgatac 3231001 gaggaggttt ccgggttatt gaccgaacct cctgccaaaa atgctcctct catataagaa 3231061 cgcttgcagc atctcttttt gaccagctct ttcgaaatac ttcgttcaaa cacaaaattc 3231121 tccccgagta tttttaaatc ctctaagatc gcttttgcat tttctgaaaa acgcacaata 3231181 tagacgttat tctttttcag ccgcattttc tttctgacca gcagctcgac cgacacatca 3231241 tattgttttt tcagcaatgt atagatgcgg cgggcaatcg ccgcgttttc ggtttgaaca 3231301 tcgagtacga gatggcggtt tgtaaatgat aaagctccat tcatccgaat gagtgcagac 3231361 agctcggcat taatgcagca gtccttcact tccagattcg ttaattcttt ttttgtttct 3231421 gatgcaaatg acatatagcc acctcatttc aaggcttcat tctttcagta aatcaacaag 3231481 aagagaggcc actttatgtg tatcgtgacg tattacgtca tttttatacg ttacaatttg 3231541 atctctgatg acttcaagcc ccatcgcttt cagctcttcg atatcaaaat caacaggacg 3231601 cgccgattcc atttcgtact tacgttttat ttcgtcggga atgtcttcac tgttcactaa 3231661 tatcgtatca ataaaaccac agcccatatg ctgattgagc gctttcacat gatcagcagc 3231721 ggtgtaatgg agcgtttcgc cgggctgagt catcacgttg caaatgtata cttttttcgc 3231781 cggcgccttt atcacttctt ccccgatttt tgggacgagc aaattgggaa gaatgctggt 3231841 atagaggctt cccgggccga taataatcaa atccgcttcc ctgattacgt ctattgtttc 3231901 cggcagcgga tcaatctgtt caggcgtgag aaaaacacgc ttaatgcgct gtccgtattc 3231961 tgggatcgtt gactcgcctg agaccacgcg gccatcttcc atctcagcat gcaaaacgac 3232021 actggcattg gcagccggca aaacctttcc tcttacattc agcaccttgc tcatttctgt 3232081 gacagcgtga aaaaaatcac cggttatatt tgtcatcgct gccaaaatca aattcccgag 3232141 agaatggcct gttaagtcat tccctttatt gaagcggtgc tgaaaaagat cttcaacaag 3232201 cggctccaca tcggataaag cggcaagcac atttctgatg tctccgggag gcggaatttt 3232261 cagttcattc cgcagacggc cagagctccc cccatcatcg gcaactgtta caatggccgt 3232321 gatgtcaacg ggtttatgct ttaggccccg aagcaataca gaaagacctg taccgccgcc 3232381 aaagattgcg attttcggct tttgtcccat cttatttccg gcttctcttt tcaatgtccc 3232441 ggtgagtaac atgagtatag taatcctttt tgaaataatc agctaaattc tcggctaatg 3232501 tcacagagcg gtgctggccc cctgtgcagc cgatcgcaat gacaacctgg ctttttcctt 3232561 ctcttttgta agatggaagc ataaagctca gcagatcaat taatttctca ttgaactttt 3232621 gcgtttcatt ccacttcatg acgtaagagg aaacctcttt atccttgcca gtcagcggcc 3232681 gcatgctttc gatatagtac ggattcggca aaaatctgac atcaaagacg agatctgcat 3232741 caattggaat accgtattta aaaccaaatg acatcacatt tacggtaaat gtctctcctt 3232801 ggtttgtcgc aaagtgcttc acgatttttt cacgcaaatc acgcggcttc atgtcagacg 3232861 tatcgtaaat gatttgagag cggcctttta attcctcaag cagctctcgt tctagcgcga 3232921 tgccttcaag cggcaggcca gtcgctgcca gcggatgcga gcgtctcgtt tctttatatc 3232981 ttgtgacgag aatggaatcc ttcgcgtcca ggaataaaat tcgcggtgtg atccacggat 3233041 tttcggccat ttcatccagc gcttcaatca gccggtcaaa aaattcgcgg ccgcgcaaat 3233101 ccatcacgag cgcaactttg ctcattttcg aatttgattc cttcatcagc tctaaaaact 3233161 tcggaagcaa tgaaggcgga agattatcga cgcagaaata gccgagatct tcaaagcttt 3233221 ggatcgcgac agttttcccc gctcccgaca ttccagttat aatgacaagc tgaatatcat 3233281 gtgattcact aacactcatc tttctccccc ctgacttgtc tttctatttg atgtgctgcg 3233341 ggtctaaacg ataactgagc agctcaaatt ccggtgtata cgtaaatgtg ccgtgcagca 3233401 gcccttgtcc cttcatcata aaatcaagga tatggccgtc tccaggggcc ataggcaggt 3233461 tctgaatgtc attgacatcg tgccactgca gtttgccttc ctctgattct gatacatttt 3233521 gtcctgtata tgaatcagcg acaaacgtaa acatcatcca ctcggagaca atgtggtcac 3233581 cgtctttaat aataaaggta aaaacgcctt ttaattgagg atttatgata tagataccag 3233641 tctcttctct gtactctctg atgacggagt ctctgactga ttctccgctc tccatcttgc 3233701 ctcccggcgc gacccaccat ccgcgtctcg gcttttgaag cagaagaact ttgtcatccg 3233761 tctgaagcac acaatttgtc actctttgca agtacgtcac ctaaccttcg tcctgtcatc 3233821 gtctctttat tataccgctt caagatgcct cccacaatga agagacattg acaatctttt 3233881 cttctatttt acagcatatt cattccttaa ttcagatgat tttgctgtaa ctggaattct 3233941 cttttattta tggacaaaaa aaggacacgg ataactggag aatccgtgcc aaaaaagtgt 3234001 attcattata aaaagggggt caattacttt attaatcata accgaaaagc attacacatg 3234061 tgttacagcg gaattaaaac ccagtaacgt aatgtgaaac tcgtatgaca gcccttttta 3234121 ttttaaggtt ttcagcgttt cttggagctc ttcgacataa tgttgtacgc tttgtgccgc 3234181 aatgcttccg tctcctgtag ccgttacgat ttggcgcagt gatttttcgc ggatgtctcc 3234241 ggcagcgaaa atcccttcaa ccttagtttc catgcggtcg tttgtttcga tatagccttc 3234301 ttcattcgta atgcccaggt tttcaaacgg tttagacaga ggaagcatgc cgatgtaaat 3234361 gaatacgccg tctgttttga attcactttc ttcaccggtt accgtatcga caagcgttac 3234421 gttaccgact ttgccgtttt cctcatgaat ttccttcaca gttttgttcc ataggaagtc 3234481 aactttttca ttatcaaatg ctctcgcttg aagaatactt tgagcacgga gtttatcacg 3234541 tctgtgaaca atcgttactt ttgaagcgaa acgagtcaga tatacgcctt cttcaaccgc 3234601 ggaatctccg ccgccaacaa cgacaagttc tttgccttta aagaaagcgc cgtcacatac 3234661 tgcacaataa gatacaccgc gtccgcccaa ttctttttcg ccaggcacgc cgattttttt 3234721 atattccgca cctgcagcaa tgatgacagc acgggcttta tattcctttg aaccagcttt 3234781 gactactttg tactctttgc cgtcaatgac ctctttaata tcgccataag cgtattcagc 3234841 gccgaatttt ttcgcgtgtt caaacatttt gttagaaagc tcaggcccaa ggatactttc 3234901 gaatccagga tagttttcta catcttccgt attggccatt tgtccgccag gaattcctct 3234961 ttcaatcatt aatgtcgata aattcgctct tgatgtgtat acagcggccg tcatcccagc 3235021 agggcccgcg ccgattataa tcacgtcata aattttttct tctgacacac tattcactcc 3235081 ttaaaccatc ttttcaagtt tgggctcttt cttataagat aagaatcccc atcaaacgta 3235141 ttccttaccc atatcctata aaatctcatg gtgatacgct atttttttgc tcaacacgat 3235201 taaatgtatt cgaaaagggt atatgttaat aaagaaagag ccttctgttt atagaaggcc 3235261 cttgtcatat ttattattga acaacacgtc ttacaacacc tttaaatgct gctttccagt 3235321 aaggattgct catagagtca acagatacgc catgagatgt attgtcgttt aggaaagtac 3235381 cgtttcctaa gtagattcct acgtgtccat ttgttttgta agtgtcaaag aacacaaggt 3235441 ctccgcgttt catttcagac gcgctgacag cttgtcctct gccaactaac gtatcagttg 3235501 ttgttccgcc tacaggtcca aggttaacac ctgcagaagc gtatgcccag cgtacgaatg 3235561 atgagcagtc aaaaatacgg ttgttgatat cagactgagt gcgtccgccg ccaaacttgt 3235621 acggagattg tcctacaatg cttgaaccaa cgctgatcgc gccttcaatt ccgccagagt 3235681 tgctgataac agtgccgcct gaattgctgt ttgagccgct gctcttctta gaagatgagc 3235741 cgtttgacga actgtttgat gaaccgttag aagaattgtc tgaagaattg tctgaagaat 3235801 catcagatga gcttgctttt gatgattcag ttgtcgccgt ttgactgtca tctgtttgtg 3235861 tttcatcaga tgctttttgt gcttcttcct gctttttgat caaagcagcc gctgcttctt 3235921 gttctttttt gatgcgtgct tgttcagctt cagtatttgc tttttgattt gcaagttcag 3235981 acgcctctga ttttaattca gaaatcgctt tagccgtttt cttttggctt gcttttgctt 3236041 cgtcgaaaag cttgtctttt tcattaagct gtttatcaag gtctttttgc attgtttcta 3236101 atttagccaa ggcagcttga acttctttca gcttgtcatt caaatccgct tcagaatctt 3236161 cgagcttcgc tttatcctgc tcttgctgtt tgattaaatc tttgtctgcg tccacaatag 3236221 atgaaaccgc agtcgcacga gagataaagt caccaaagct tgttgatcct aaaagaacat 3236281 ctatgtatcc ttgagatccg ccgctttcct gtaaagaacg aacgcgtttt ttcaggattt 3236341 cattgcgttt ttcgatgcgt gcttcagttt ctttaatctc ttttttcagt tttttgattt 3236401 cttcttttgt tttatcgttt tcttcttttt tatcttcaat cttgttgctt gtatcaagcg 3236461 ccttatcgtt aatgtctttc agttcttttt caatctttga ttgattttcc tgaagctcgg 3236521 ttaattcttt ttccttcgct tcaatgctgg aagcaacctc agattgcttg ctttcgattt 3236581 tttgtttctt ttcatctaat gtttccgccg atgcagtttt acttgtaaat gggatcaaaa 3236641 aactgcttgt cccgatgacg gaagccaaac caagtgtaat taaactcttt ctcacttttt 3236701 atatcctccc ttttactgtg aacctgtcct catttggaat cgtattttga acatcaagtt 3236761 tcgttcctca tactctacga ggaatgatgg ttgtttatgg ttaattattc tgtgcatctc 3236821 ttattctggt tgtatagcgt ttatttcaca tcatatgtaa aaaacactaa ttccttatgt 3236881 acgagaatca ttataccatc aagtttcgac aaattagcga taaattttat tacatttatg 3236941 tttcaaacag atgtcaagtc acacatcatt tgtcattttt cttaagcgtg taaaaaaact 3237001 gtcgatatta ttttcttaat ataatctatc taacaaaaaa agagtcgatt aaataaatca 3237061 actctttaaa atttactatt ctagaatatc atcaatatat ttcatatatt tcgtcaaagt 3237121 tgccggagag atgccgaatc gggccgctgt gtcttttttc gtgtcttgct tgccatgggc 3237181 ttctttccaa atataacaga tggctgctgc ccagcctttc tcattcttca acggagcagc 3237241 tgcacgaatt tgctggatga catgaaaaac ccagcagctc atgacttctg ttttcatctc 3237301 ttctttttca gcttgctcta atagtttgac cgtttgataa gcgaaaagtg catcctctga 3237361 aacgtcagca gccgcagaat ctccattcag aagcagcttt acaaaatgag tttcaaaagg 3237421 agcggtaatt ctctttgagc gtatcaccgc ttcaagatgc tctgtttctc cctttgtgct 3237481 gctgatataa taggctgcga gtcgctgctc cacagatgaa ggaagagctt ccctccgctc 3237541 aatccaaggc gccgggcggt cttcgccggg atattgcgac tcgacttttc tccagatcgt 3237601 ctcggcaaag tcggtatgtc ccgtaaaata agcagagcag gaaagccagt aaaagaaggt 3237661 gtcgtcaccc tcaaagccgg ttttatataa tgatttgagc catttatatc cgatctcgta 3237721 gcggccgaca agcgccaaag tagcacccaa tttataacgc tgctccaata gcatcggata 3237781 gacattggag agctgatcac tcaattccgc cactttttcg tcttctcttt cataatagta 3237841 gaaaacgaga agattgcata aggcgtgaag atttccttca ttatgagaaa gcacttcata 3237901 agcggtttgc ttcgctttta caacgtttcc tgaatagaaa taggcaagcg cgagattgtt 3237961 gtatgctgac caaagctccg gatattcagt tgtgatttcc tcaagcgccg caaccgcttc 3238021 agcaagctgg ccgctttcca gcaatgactt tgcccgatcc tgtttcacca gcagttcatc 3238081 ctgatcatac aacgaatcct caatgccgtc gtctcctaaa tcgagcaaat caagcagact 3238141 atcgttttct tcggcgaatt caccatccgg gtccgcatca gaataagcgg ccgcttcttt 3238201 ataagcttcc tggaagagcc ccagatgggc aaagttattc gctttaaagt aatggcactc 3238261 cggcatttcg gcctccagat ttgccatgat atagtcaaga agatcgttcg actcttgata 3238321 ctggcccatt tccgaataaa tgaccgcaag ctgtgaaagc atctctgaat cctccggctc 3238381 caaatgaacc gcgcgctgaa tcagtttgct tgcccgtttt agattgcgct ctttatacgc 3238441 tttcaagcct ttatgaaaaa aatattgtcc atcttgaagc agctggacaa tttgtgcgtg 3238501 atttttatgt tcagaagtgt gttttcccac aactaccctc cgttttatac aatattaccg 3238561 tcagtagtat accataaatc gtaagcccct caatagttca aaaggaagga ttgggaaaat 3238621 ccctcctctt ttttattggc tgattcgacc aaaatttacc cggctttgtt ttctaagtcc 3238681 gcattcattt tcagctgctg ttcagcaaaa tcccggtaaa ggccatggga agccattaac 3238741 tcatggtgtg ttccacgacc ggtaatttcc cctttttcaa caaacaaaag ctggtccgca 3238801 tctacaacgg tagataggcg gtgagcgata acaatcgttg tgcggccctc catcagcacc 3238861 tccagcgcct gctgaactga tttttcagat tggctgtcga gacttgaggt agcttcatcg 3238921 agcataagaa tgcttgggtt acggagaagc gctctcgcaa tcgcgattct ttgcctttgt 3238981 ccgcctgaca gcataatgcc gcgttcgccc acttctgtat caaactgatt cggcagctcc 3239041 tttataaaat tgagcgcata tgccatctcc gcggcttttt cgatctcagc atccgtcaca 3239101 tctcgttcta acccgtagca aatattttct ctgattgtcc cggacattaa cgggctttcc 3239161 tgtgatacat acccgatatg ctccctccac gattcaagcg agtaagtatc gaccggctcg 3239221 tcccccagcc gaatggtccc tgcagtcgga gaataaaagc gttcaagcag cttaaacagc 3239281 gtcgtttttc ccccgccgct cggaccgacg atcgctgtca ctttccctgc ttcaatgacg 3239341 gcgctgacct cttttaagat cagctgatca ggcttatatc caaaagacac gcgatcaagc 3239401 tggataggca gatgtgcatt ttcaatttgt tttcctgtca ctgtatcttc ctcttcctct 3239461 gccaaaatct caatcattcg ttctgttgca ccgattgatt tttgcagctg tgtgaaaaac 3239521 gttgtaatct ggcccatcgg cataataatt tgaaacaaat ataaaataaa agccacgagc 3239581 gctccggctg tgagctcgcc tgatgagacc tgcatgccgc catatccgat cactgcgaca 3239641 agcgctgcca ttaacacgag tgaaataagc gggccgacaa gcgattgaac cttggcttca 3239701 cgaacgccaa gcttaaataa tgaggaaatc cccatcttcc cgcgcccata ttcgacatcc 3239761 tccgcatttg aagccttaac aagtctgatt tccgggagaa tttgattaag caggcctgta 3239821 aaacgagccg tttcatcttg cgtttcccgt gaaatggaga acattttccg tccaatcggc 3239881 accaaaataa gagcggccag cggaacgacc actaacacaa gcagtgtcag cttccagttc 3239941 ataataaaca agattgtcaa tgatccaatg acagaaatga tgcctgtaat aaatccgctg 3240001 atatgggttg taatcaattc tttgaccacc atcgtatcgt tcgttacacg gctgactgtt 3240061 tctccggaag catttgtatc gaaataagag acaggcagct taattaattt cttccataat 3240121 aactcccgca gcccggaaat gattttttgt ccattatagt taagcgcata ggtggcataa 3240181 gcgcttaaac ccgcctgaac gaaaaacacc agcgcgatca aaccgatttg cgtgcctgac 3240241 agatttgaca tagaaaaacc atcgacaagc tgcttcgtta ataatggaat gagcaggctg 3240301 accagcgtgg ttactacact gagggcaagc gcaaaggcga gctttccata agaaggattg 3240361 gtccgtctta ctaaggcaaa aaagggtttc aatttacttt tagatttttg tttcttggtt 3240421 ggcatatatt ttcctcctgt ttcagcgttc agaaaggtga aaagtcatag caaaaggatg 3240481 atttttactc tttctcaatc atatcaatgg agaaagactt tttcagtata tttttgccgt 3240541 gatcaaaata aaaatctccc actcattgtt tgaataggag atttttgtgt tagacatctt 3240601 tcactggctt cttttttctg taagtcaatg ttacatcctg ctgtcgcagg tcttctatta 3240661 tcattttgta ccgatcaact tttgcggtat gttcttcttt tatcatctga agggcagctt 3240721 ttcgtttttc gctattagac tcaagctctt tttttatttt ttttacaatc aacccttttt 3240781 gccctttgat ttcctctttt aatgaagact caaatttctt tgtcaggctg agaaagtcgt 3240841 tgatcggttg attgagggtg cccgctttcc ccttcatttc atcttgggta agaaacatat 3240901 aggtcgttga tacaatttct gtttcacttt ctgaaaataa ggaagtcact cttcatattc 3240961 ctcctaagac tgaaaatcaa ataactgaga aatcatttct tctttttcaa acagcttttc 3241021 aatactctcg cggatatttt tgataaaatc tcttttttct gttgtctgtt tttttaattc 3241081 agcaacaatt ccatcatttg caggaagcgc acctgtgtgg aatgattcat gaactgagat 3241141 tttctccaat ttatcgaatg tgtggctgaa accagctgca agccggaatt gaagatcgaa 3241201 ggcataatgc gaagggtttt cttccatatg atgaatagcc gtgatgatcg cctgcttttt 3241261 gtctatgaag tcttcatcga tttcctgact gtaaaccttc tggtacttag aaatcgcatc 3241321 ttccatatct tcaacgattt tcataccgtt ttgatagatt ctgacagcgg atgagagatt 3241381 gacttgaatc gtttctcccg agccactctt ccctgtaaaa taaatatcgg agcctttata 3241441 gctgaagcct ttttcctttg acaaggcgtt gagcatttga acgatgctgt ggccgtcgac 3241501 gataagtttt agtgcgtctt ttgtttctgt gtcgagtgtt ttcaatgagg acagaattga 3241561 ttttacatag tccactattt caccaacgtc ttttaaagct tgcataaatt ggccatgttt 3241621 tagatggtct atgaaatgtt cgtaccgtga ctctatgcct cgcatactcg cattaatatt 3241681 cgttaattct tttttgatga ctttcttttg cgtttcatca atataaccat tttcagctaa 3241741 ctgatctacg accggtccgc tgtttctcaa caaggtatga agaaaaccta aaaacgacgg 3241801 cagttcctct tttattcggc catacatttg cttaacatca tcaaaatgct catataggac 3241861 acttactttc tttaaagcgc cgtctgtgtt tttcactttt tcaatcaggt ctatgtctat 3241921 cccgctggct gcctttataa aaccgttcaa gccgtctttt tcatagtcat ccttatattt 3241981 ttgaaggaat ttttgaattg acctcacatc ttcgtcagga accccatcca taatgtttcg 3242041 gatgcctttt acacttgtat ttgtatctgc catcttcaca tcaccgaatg taataaaatc 3242101 ggccttgccg ctgactccat acagcgggtc atcttttgag atgcgctgag tgatgtttgt 3242161 tgttacgcct ttgtcttcat aatatttttg gatttctttt tttaactttt ctggcgggat 3242221 ggaatctata tcttcatatt tataactaaa tttcctaata acatatctat ataaactttc 3242281 atcagtttca agtaattgat caatattgac ttgagctcca tttaccccat aaacttcatc 3242341 atattctcca tcaatcaatt gcaccataac ttggttatta tttgcaagtg aatgtcctaa 3242401 ggcgaatgtt tttaaatcct cagagttacc tgctgctttc tttgctttgt tagtaaactc 3242461 ctttgtagcc tcatactgac tatgatcaat tcctaaaaaa agaccaaaaa agttatatga 3242521 ccaatcctta ttatcggcac taccttctga aataatctga agctgatcaa tatgtttttt 3242581 ctcatctatt atatggattg ccgttccatc gtaacctgat tctctggtcg aactttgtat 3242641 acttgtattc tgatttacaa gttcattgga ggtgtaaatt tcaattttca tattctcagg 3242701 aagatcgtgg tgggtttcct ctttataaat tctgcgtata tctgcttcga aatccttctt 3242761 agctttctta acttcactcg caatagttga ggcaaacttt tgtttatagt catattctaa 3242821 atcaattaac cttaacttta cgttctcatt ctcaaataca tttttatttc ccatcttatt 3242881 tctccttttt atctattaaa aaggtgatag aattaattaa tttctcaact ttatttttag 3242941 ccttttcttc atctaaggag catggttgat tttcattttt gcatccaagg gtaaaggcgt 3243001 attctactcc taggttatct tcctctgtag acttaacata tccaaaataa ctgtatgaat 3243061 aattatattt tctatcaata tcgtcaaaga tgtctttttt cttggcagtg taaatatccg 3243121 ttttcttttt gctgcttttt ttgtattcgc ctttataatc attttttcca ctaacaatat 3243181 ctagcattgt cttaggttca ttcgcaaaac tttcttcttt gtaatatgtt acatggccat 3243241 caaacattac attggtgtct ttatcataac tattaaatcc aatactttct ttgtttttcc 3243301 cggttaacga tgatcttctt gatagatact ttccatcctc cggaaacaac atcctaaacc 3243361 ctttcagctt agattccagc aaataatatc ctggttcctc ttcttttgtt gacaccatgt 3243421 actctctcgt tttctcgtcc tgaaacgcag gtacttgagg cagatccttg ggatccatgt 3243481 cttttggttt taccgcttct gttttattgt catttgtgct gtttttatca ttgtcattca 3243541 tactgcatcc tcctgtcagg gcaagtaata agctgaagca aataaagatg atctttttca 3243601 ttacgaacct ccacgggttt tgtgagaata gtattctatt tttatatcaa aaataattct 3243661 attgacctgg ttaagagatg attatttcat cctttttcat gttacatcat ggcggaattt 3243721 ggataaatag gaaatgagac tcggttttga tctcctttta ttaactaatc atatataaca 3243781 cccaatataa atctaaatac ctattacttt tttcacaaaa caaaaagagc cgtatcatcc 3243841 ggctctttac tcttcaatct cagaatggcg ttttttcaat acgtcaagca catcatccag 3243901 cggcagggat tgttctctga gcaggacaag caggtgatac agcaggtctg ccgcttccca 3243961 tttgagttcc tcatgatccc ggtttttcgc ggcgatgatg acttcggatg cttcttctcc 3244021 gacttttttc aaaatcttat cgacgccttc acggaagagg tacgtggtgt aagctccttc 3244081 aggcatttcc gcttggcgtt ccgcgatcac ccgctccagt tcgttcatga tgccgaatcg 3244141 gtccgcggcc tgttcttctg tttgttcctt tgtaaaacag ctgtagctgc cagtgtggca 3244201 tgccgggcct gacggttcta cgagtacgag cagcgcgtct tgatcgcagt cataccggat 3244261 acctttgacg gcttgcgtgt tccctgaggt ttctccttta tgccataacg cttggcgtga 3244321 gcggctgtaa aaccatgttt ccttcgtttc cagcgttttt tcgtacgatt ccttgttcat 3244381 atacgcaagt gtcagcactt ctttgcttgc cgcatcctgc acgatagcag gaattaatcc 3244441 gtcctcgtta aaacgcagtt catctgcctg tttcatctca cattcacccc gtactctttc 3244501 aagtatgatt tcacttcttt aatcgatgtt tctttataat gaaaaattga ggcggccagc 3244561 gcggcgtcgg cttctccttt tgtaaaagcc tcaagcatat gctgtgcgtt tcccgcgcct 3244621 cccgaagcga taacagggac ggggacagct tcggaaacaa gctttgtcag cgtgtggtcg 3244681 aaaccttttt tctcaccgtc ggagtccatg cttgtcagca atatttctcc tgccccgcgt 3244741 ttgacgcctt cttttgccca cgcggtgacc tcccaatctg ttttctttct gccgccgtgc 3244801 gtgtagacct tatatgtgtc agattctttg tcatacttgg catcaatggc aagtacgatg 3244861 cattgagaac cgaaaaactc ggctccttct gtaatcagct cagggcggag aacagctgcc 3244921 gtgttcaccg acactttgtc cgctccggca cgcagtatcg ttttcatatc gctgagctga 3244981 ttgatgccgc cgccgactgt aaacggaatg gcaagcttcg cggcaacctg ctccacaacg 3245041 tcaaccatcg tctttcgtcc ttcgtgcgag gcggagatat caagaaaaac aagttcatcc 3245101 gcaccttccc ggtcgtacac ttcggcgagt tcaactgggt caccggcatc cttcaattcg 3245161 agaaattgaa ttcctttgac aacgcgtcct tctttgacat caaggcatgg gataatccgt 3245221 tttgtgatca tttgcgcttc accctttcaa gcgcctcact cagcgtaaac tgattggtat 3245281 acagcgcttt tccgatgatc gctccagaga cgccgtccgc ctcattgcgg gcgagagctt 3245341 cgagatccgc gacggagctg actccgccgg aagcgatcac cgatttcccc gtttccttag 3245401 caagctcgac cgtgctttta acattggggc ctgacagcat tccatctgtc gcgatgtcag 3245461 taaaaataaa gacttccgca ccttcattgg ctagctcttt gcccagttca gttgccttaa 3245521 gggttgatgt ttcaagccat ccctctgttg aaacaaaacc gtttctcgca tccagtccga 3245581 ttgcaatttt ctcgccatat tgtttcagca tttttttgac aaacggaggg ttagaaactg 3245641 ctgagcttcc caggatcacc cgctcgactc ctgctgataa atattcatag acgtcatttt 3245701 cagaacggat cccaccgccg atttcgactt tcaggttcag cttttgcgca atctcaatca 3245761 catggcggtc attcactctt ttcccttctt tggccccgtc gagatcaacg agatggatcc 3245821 attcggcacc ctctttctca aataactcag ccatgtcgta cggtgaatcg ccatatatcg 3245881 tttccttatt ataatcccct tgaacaaggc gaacacattt gccgtttctc atatcaattg 3245941 ccggatataa tgtaaaagca ctcatttttt caccttctgt tctgctgcca ttttcgtaaa 3246001 ttgggttaaa atagacattc cgaccgtgct gcttttttcc ggatgaaatt gggcgccgaa 3246061 gacgtttctt tttccgacta cagcaggcac tcgtacacca taatcggcgc ttgccagaag 3246121 cgcgttctcc tccatcccgt caatgtaata ggaatgaacg aagtaagcgt agccttgttc 3246181 tgttttagtc agcagcggag attcattatg aaaagaaaga cgattccagc ccatatgcgg 3246241 aaccttcagc ttgtttcctt tttcatcttc tgctttcagc ctgactgctt ttccttttaa 3246301 cagcccgagt cctgaagcgg tgccgttttc ttcgctttct tcaaataaaa gctgcatgcc 3246361 gaggcagatc ccgagaagca gccttccctc tgagaccata tcgtgaatca attgatcaag 3246421 cttcgtgtag cccaaattgt ccatcgcgtc tccaaatgaa ccgactcccg gcaaaatgaa 3246481 agcatcagct tctttcagct cctccggctt ttcagaaaca aaatacggca cgccgacacg 3246541 ttcaagcgcc tttgagacac tgtataaatt ccccattccg taatctatca cgccgatcat 3246601 ttacagcatc cctttcgttg acggtattcc tttaactcgc ggatcgatcg ttgtcgcttc 3246661 atcaagcgca cgtcccagtg ctttaaaaac ggcttcaatc atgtggtggg tatttgttcc 3246721 ataatgaacg atgacgtgca ggttcattcg agcttcgagc gccagcttcc acaaaaattc 3246781 atgtacaagc tccgtatcga aagttccgac tttagcagcc gggaaatcag cgcgcatttc 3246841 taagtgcggc cggttgctta aatcaatcac aacttgagca agtgcctcat ccatcggcac 3246901 aaacgccgat ccgtagcgtt tgattccttt tttatcgccc aacgcttcga gcagcgcctg 3246961 ccctaagcag atgccgatat cttcagtcgt gtggtgatca tctatatcaa catcgccttt 3247021 tgcgttaatg gaaagatcaa attggccgtg tttcgtgaat aaatccaaca tatgtgtcat 3247081 aaacggcaca tctgttttaa tatccgcttg tcctccgccg tctattgtaa atgccagctc 3247141 aatatctgtt tcgtttgttt tcctgacgcg ttccgctttt ctcatttaga aatcctccgt 3247201 tctctcgctt caattgatct ggcatgggct tctaaccctt ccagtctggc aaaagccgcg 3247261 atgctttcgg catgttcttc aaaggctgat tgactgtaag aaataatgct cgatttcttt 3247321 tgaaaatcag ttacgtttaa tggacttgaa aatctggctg ttccgtttgt cggaagcaca 3247381 tggttcggtc cggcaaaata atcaccgaca ggctcagggc tgtatctgcc taagaaaatt 3247441 gcacccgcat gtttgatact gccaagcaaa gcttccggag actgtgttat gatttctaaa 3247501 tgctctggcg cgagtgtatt gacagtctca atcgcttcta ccattgtttc cgccacatat 3247561 atacaaccgt aatctctcac tgaagcttcc gctatttctc ttcgcggcaa ggtttccagc 3247621 tgcttattca cctcggctga aaccgtctcg gccagcgcca tggaatctgt gacaaacaca 3247681 catgagctaa gcttatcgtg ttccgcctgt gacagcagat cggctgcaat ttcgctcgga 3247741 atcgctgttt catcagccag cacgacgatt tcactcggtc cggcaatcat atcgatatcg 3247801 acatcgccga acacttctcg tttggcaagc gcgacataaa tgttgcccgg acccgtgatt 3247861 ttatccaccg gctcaatggt ttctgttccg tatgctaacg ccgcaatcgc ctgagcgccg 3247921 cccattttgt aaatgtcttt tatgcccagc tcggctgcag caaccaaaac tccaggagac 3247981 agcagaccgt cttttcccgg aggcgtgacg agaacgattc tttcaacgcc cgctacgagc 3248041 gccggaatca cattcatcaa aacagatgaa ggatatgcgg ccgttccccc cggcacatat 3248101 acaccggcgg aatccagcgc cgtcactttc tgccccagca ttgtgccgtc ctttctgtga 3248161 taaaaccagg aggattgcag ctgtctttcg tgatattccc taatattttc gattgcctgc 3248221 ctaatcacct gaagaagacg tgaatccagt gaggtgtatg cctcctcaaa ttcttctttt 3248281 gtgaccagcg ggctgtctat ttcgatgcag tcaaatttcg ccgtgtagct gcgaaccgcc 3248341 tgatcaccgt ttgctttaac atcttcaata atggaccgga ccgtctttct ttgctcttcc 3248401 gttccggcat cgatggaacg cttgagagaa agccgttccg ctccgctgat ggttttgatc 3248461 ttcattttgc cgtctctcct tccacaacga gagataggcg ggatgccatt tcgtcaatca 3248521 catcgtcttt catgcgatag cttaccgggt tgacaataaa gcgagaggta atgtcacaaa 3248581 tgtgctccgt ttcaacaagc ccattttctt tcagcgtctg tcctgtggaa acaatgtcca 3248641 ctatccgatc tgcaagccca atgagcggag ccagttcaat tgaaccgttg agcttaataa 3248701 tctcgacttg ttctccctgc tctctgaaat aactggaagc cacattcgga tactttgtcg 3248761 cgattcttgg cgctactccg ctccagtctg tattcggaag tccggcgaca gctaagtggc 3248821 atttgctgat gtttaaatcc agtacctcat acacatcgcg ttcctcctcc agcatgacat 3248881 ccttgcccgc aattccgacg tctgccacgc catgctccac atacgtggtt acgtccatcg 3248941 gcttcgctaa tataaaccga agattttcct ccggcacatc gatgatcagt tttctcgaat 3249001 cttcaaactc ctcagggagc ctgtagcctg cctgcctcag cagccctgcc gcttcttcaa 3249061 atatccggcc ctttggcatc gccattgtga gtaacttacc cattttgctc ttcctttctg 3249121 gcaccgataa aataagtgac gtttgcaaaa gattttgtca tctggtcgat attttctatt 3249181 cccgataaat cttgaagaac cactttgttc cctttcatgc gttcttcatt cgcataagcg 3249241 atggcttgcg cccgctgctc tttgctgaaa ataacagcgt ctatttcaca aggttcgtcc 3249301 ttcatatgaa gggcttcaat cagccggtcg atccgaagcc cgaagcctgt tgccggtgca 3249361 ggtgaatcaa aatggcccag cagcttgttg taacggccgc cgcttccaat gacaaaaccg 3249421 acattctcgg cgtacacttc aaataaaatc cctgtgtaat agctcatgtg gctgaccata 3249481 ttcagatcca ggcggacatt ttccgtacat ccgtaatcct caagaatgtc ccacagcgcc 3249541 ttcagctcat caaccacgct ttttccttgc gcagaatcga cgatttcctc ggcacgtccg 3249601 catacttcta taccgccccg cagttcaagg agctcaagca gcctgctttt atcaatggag 3249661 gaaagcggga gagacttgac atgctctctg tagccgacgt agttcttttc atataagaac 3249721 ctccgcagca catcagctcg ttcaacgttt ccgagcacct caacaaacaa agcatccgca 3249781 atgccggcat ggccaattgc aattttaaag gatgccagcc cagcgttttt taatgccccg 3249841 acgactaaag caatgacctc cgcatccgcg ctcgtcgtgc cgtcaccgat taactccact 3249901 ccgacctgct cgaactcagc cggacgtccg ccttcacgct cctgagccct gaatacattt 3249961 gccgcatagc cgactcttag cggatgaccg tgtttcagaa gcttcgatgc cgccaccctt 3250021 gcaatcggcc ccgtcatatc cgggcgaagc accaatgtct tgccgtcctg atcaagtagc 3250081 ttaaacagct gctgctcttc aattgctgac tggacgccaa cggtatcgta aaactccagt 3250141 gtcggcgttt ccataaattg atatccccat ttatcaatca aatcggttaa cgatcgtctc 3250201 accttttttt tcgtttcgta taaaccgggc agtgtatctc tcatgccgtg cggtttttca 3250261 aacataaaca tcaacccgag cacctccgct gttatcttat gaaggaaaat tccgaatcct 3250321 ttagttcgct aatatgataa tatgttagca gatgaaagaa tgaaaatcaa cgcttaactt 3250381 cagtaaggat atttttagtt caaatatcct tctcctcatt atgaaaaaat catgaataat 3250441 gtattaaagg tacgtaatat ctcaaattct ttatgtttgg catgctataa tacaaatcaa 3250501 atagagaaca aggagataaa gatgaaaaca ctgcgaactc tatgtgtcct gatgattctt 3250561 tcaggcgtta tttttttcgg acttaaaata gatgcaaaag atatagatat tccttttttg 3250621 aacagcctta aaaaagtggt ttctgatagc gatacagact cagctgcgaa tagcaaaaag 3250681 gagctgaagg gaagcgcaaa accgctggat gtcatccttt acaatcaaat ggacgcaccc 3250741 cggctctata acggctgtga agtaacaagc cttgcgatgg tgctgaatta tgcgggatac 3250801 gacgtgacaa aaaataccct ggcaaatcag gttgccacag tgcctttgac atacagcagc 3250861 ggattaaagg gtgatccgaa tgacggattt gtcggggata tggcgaatgg ccctggtctc 3250921 ggtgtctacc atcgaccgat ctatcagctg gcgaaaacct atgcgggaga caaagtgtct 3250981 gatctgactg gaaaaagtat ttccgctgtt tatcagcagc ttgaaaaagg caatccagtt 3251041 tgggttatta cgacagccaa ctttacgcca gttgacaaca tgcagacatg gaaaacgcca 3251101 aacggaacga tagaaattac gtacagcgaa cacagcgtcg ccgttacggg atatgatgat 3251161 aaatatgtgt atctcaatga tccgtatggc tataaaaaca gaaaaaccga tagaacaagc 3251221 tttgaaaaag cgtggaaaca aatgggcagc caggccgtgg ttattcaaaa gtaaacacct 3251281 gaagcctcac tatgctctat tctgagcaaa tacgacaata ttcatgcttt ttgtatcaat 3251341 cggtaagatc gattcatttt ccatttttca cccaaaattg tctttacttt caggctgtct 3251401 gtttttatga ttaaagcaga ttcagccttg ccccgatcta tgcgagagaa gccggtgcaa 3251461 gtcgctgacg cttctcttgc aaaaaatgaa agatatccgg ggaggattta tcattgaaaa 3251521 aaatcgtgtc tatcctattt atgttcggtt tggttatggg tttcagccag tttcagccat 3251581 caaccgtttt tgcagctgac aaagtggtgc acgaaacaat tatcgtacca aaaaatacaa 3251641 catatgacgg gaaaggacag cggtttgtgg cagggaaaga attaggtgac ggaagccagt 3251701 cagaaaacca agaccctgtt tttcgtgtgg aggatggagc aaccctgaaa aatgtggtgc 3251761 ttggtgcacc tgcagctgat ggcgtgcaca cttatggaaa cgttaacatt cagaatgtga 3251821 aatgggaaga tgttggtgag gatgcgttaa cggtgaagaa ggaaggaaaa gtgacgatcg 3251881 acggcggttc tgctcaaaaa gcgtcagata agatattcca aatcaataaa gccagtacct 3251941 tcacagtgaa aaatttcacg gcggataatg gcgggaagtt cattagacag cttggtggtt 3252001 caaccttcca cgttgatgtg atcatcgaca agtgcaccat cacaaacatg aaggaagcga 3252061 tattccggac ggacagcaaa acaagcacgg tcagaatgac aaatacacgc tactctaatg 3252121 tcggtcaaaa atggattggt gttcagcata tttacgaaaa caacaacact caattttaac 3252181 aaaaaaagtc cgctgatgtt attcagcgga ctttttcaat ctttcttgca tttcttcctt 3252241 cgtatagatg atcctcatcg gatttccgcc gacaaatgcc ccgtcaggca catccttatg 3252301 gacaagcgtt ccggcggaca caactgcgcc atctcctatt ttcaccccgg gcagaatggt 3252361 cgtgttggca ccaatcatca cttcgtcccc gatcagaact ttgccgatcc ggtattcgtg 3252421 aatcaaatac tcatgggcca gaatggtcgt attgtacccg atgattgtat ttgttccgac 3252481 tgagatcttt tccggaaaca tgatatctgg catcaccatg agggcaaagg atgtctgttt 3252541 tccaaccttc atccgcagaa atgtgcggta cagccagttt ttcatcccta taaacggcgt 3252601 atatctcgca atttgaatga caatgaaatt tttgacgacc tttaaaaaag gtaccgtttg 3252661 atagacatgc cacagtgagt tggcccccga gaccggatga cgatctgttt ttctcacaga 3252721 ttacttcact ccaacgattt gtaatagatc actcattttc tcaagcataa aatccggctc 3252781 atgcttcgcc agcatttccg gccctttaat cgtccatgcg actcctgccg tttttgtacc 3252841 ggcgtttttc cctgccagca catcatggta attatcaccg accataatgg cttccgccgg 3252901 ctcgcttcct agctgtttca gcgctaacag cacaggctcg ggatcaggct ttgcattcgt 3252961 cacatcatca agggtgacaa ctgtttcaaa gaattcgccg attcccgtga gcttgaggcc 3253021 catattgaca gtatctctta attttgttgt cacaattcct aatgtaaagc cggctttttt 3253081 taatgcatcc agggtctcat ataccgtttc atattcagtg acgagtgaat catgcatgtc 3253141 atgattgtac gctctgtaca tagcgatcat atcctcgcat ttatcagggt ccatcgaaga 3253201 gaacgtatca aaaagagacg gcccgataaa tgcaaggaca tcttctcgtt tatacttgct 3253261 cggataataa tgctccagtg tatgcaaaaa ggacgcgata attaattcat tcgtattaat 3253321 aagcgttccg tctaaatcaa acagaatcgt cgttacttgt ttgtcactca tattgcttcc 3253381 tttccaaccg ctgagggttt ccattttttc cacgtgtgcg caatagccat tgtcagcaga 3253441 actgctgtgg tgacacgaat caaaagaagc ggccagaccg gtatgccaag cggaataaag 3253501 acaagtgtat cttccacgac cgcgtggcag gcaacgagaa atataaatgc caatgtcatg 3253561 tcccgcttgc tcacgccgtc atcctcgaca gctttgatca tgacacccgc tccgtaggcc 3253621 agaccaatcg tcagtcccgt caccatcgtc atagacgtat ttttattcat gccaagcagc 3253681 tgcgtaaacg gcgacagcca cctggaaaac cgataaagcc agcctaaatc tcttaaaaac 3253741 tggatgataa tcatcagcgg gatcactatt gccgccagct gcaaaacacc aagtccggct 3253801 ttcgttaatg cttctgccaa cattcctagc cagctgtctg gcgccgcgct cttcgcagcg 3253861 ataaaaccgt actgcgccgt ttcctttccg ccatgccaaa tgaggttgat gacgatggct 3253921 gacacagcgg ccaaaccgat gcgcacggcc aatatgacgc caattctgat accaaccttt 3253981 gcggcaactg tcgattcgat aatcaagtta tgacagaaag aaagcataac agctaaaata 3254041 aagacttctt tcacagataa atccaatgtt aaaatcccgg caattcccgc atacagattc 3254101 agcatatttc ccagtacaag cggaatggcc gcttcaccag aaagcccgaa gagacccatt 3254161 accggtgtga tcagccgtac aagccaatcc atgacagggg tatgctggag caaagtgacc 3254221 aatagcgtta ccgggaaaat cactttaccc agcgtccatg ttgtttgaaa acctgctgca 3254281 agaccggcca gaaagatctt cttcatccct catccccctt tgttgacgtc tactccgcgt 3254341 accgctcctt cgagtatccc ttgacgcgtc tgaagatgat ggctgccaca gccaaaacaa 3254401 tcaatacgat tgaaatcacc tgagcgatgc gaagtgaatc agtcagcatt aagctgtcag 3254461 tccgcattcc ttcaataaag tatcttccga ttgaatacca aatgatatag atcaagaaca 3254521 tctcgcctct acgcaaattc gctctgcgca gcagcagtaa aacaatgacg ccgacaaagc 3254581 tccatagtga ttcatataaa aaagtaggat gataatattg cccattgata tacatttgat 3254641 tgatgataaa ttcaggcagg tgcaggtttt ctaaaaaggc tctgctgaca gcctcgccgt 3254701 gcgcttcctg attcatgaag ttcccccagc ggccgatcgc ctggccgagc aaaatgctgg 3254761 gcgcggcaat atccgcaagc ttccagaacg aaaggttttt cactctcgaa aacacataac 3254821 ccgttaaaat ggcgccgatt aatccgccat gaatggcaat gccgcccttc caaatcttaa 3254881 tgatttctcc cggatgtgcc gcataatagt cccattcaaa ggcaacataa taaattcgtg 3254941 cgcaaataat cgcaattgga atggcaaaca ggacaagatc aataaacgta tctttctgca 3255001 gcccccgttt ttcactttcc ctcatcgcta tccacagccc gagcaaagcg ccgagaccga 3255061 taatgattcc gtaccagtgg acggctaacg gccccagctg aaatgctatc ggattgagtg 3255121 gttctatcgc ttcattcatt taacgccaac tcctattctt cttgttcacc gtcttcaatg 3255181 acgtccgcca gcttgttggt aaattgttca gcggcattca gccccatccg cttcaatctg 3255241 aagttcattg ctgccacttc gatgatgact gcaagatttc ggcctgggcg gacgggaatc 3255301 gtcagttttg taatttctgt atcaatgatt ttcatggtct cttcctcaag tccgagccgg 3255361 tcgtattgct tgccctgctc ccagagttca agattcatga caatcgtgat tcgtttattg 3255421 cttctgaccg cgccagcgcc aaatagcgtc atcacattga taatgccaag gcccctgatc 3255481 tcaagaaggt gctcaattaa ttccggagcg tttcccacaa gagtatcctg atcctcctgc 3255541 cgtatttcaa cgcaatcatc ggcaacaagg cgatgccctc ttttcacaag ctctagcgct 3255601 gtttcgcttt ttccgacgcc gctttttcct gtgatcagca cgccgacacc atatatatcg 3255661 acaagaacgc catgaattgc tgtggtaggc gccagcctgc tctcaaggaa gttggttaaa 3255721 cggcttgaca gtcttgtcgt tttcagcggc gatctgagga caggcacccc atttttctcg 3255781 gaggcgtcaa tcagctcctg cgggatgggc atatctctag aaagaataat agctggtgtt 3255841 acatcagtgc acagagaatc cattcgctgc tttttctcct cttcaggaag ctgttcaaag 3255901 aaagaaagct ctgtttttcc gagaagctgc acgcgctccc tcgggtaata tgtaaaatat 3255961 ccggcaattt caatacctgg tcttgatagg tcactcattg taatcgggcg gttaattcct 3256021 tcttctccgc tgattaattc caaattgaac tgttccatta cgtcttttgt gcgaaccttt 3256081 gccacgatat gttcctcctg ttccgggctg ccccgagctt gctcacaata ctttcatttt 3256141 atcactttcg ggcttgaacc taaaacagat tttataaaag gggggaaaac acctcagctg 3256201 gtctagatca ctagtctgaa aaagagtaaa ataaaggtat tcaaattcca gaaaggcgga 3256261 tcatctatgg cagagagtct tcttatcaaa gacattgcga tcgtgacaga aaatgaagta 3256321 atcaaaaacg gctatgtcgg aatcaatgac ggaaaaatca gcacagtttc aacagaacgg 3256381 cccaaggagc catattcaaa agagattcaa gcacctgcgg attccgtttt gcttcccggc 3256441 atgattgaca ttcatatcca cggcggctat ggcgcagata caatggatgc tagcttttcc 3256501 acgctcgaca tcatgtcgtc aagactgccc gaagaaggca cgacgagctt tttagccaca 3256561 acgattaccc aagagcatgg gaacatttct caagctttgg tgaacgcaag agagtggaaa 3256621 gcggctgaag agtcctcttt attaggtgca gaactgctcg gcattcattt agagggcccc 3256681 tttgtttcgc ctaaaagagc cggagcgcag ccaaaggagt ggattaggcc ttcggatgtt 3256741 gagcttttca aaaagtggca gcaggaggcg ggcggactga tcaaaattgt tacacttgcg 3256801 ccggaggagg atcagcattt tgaactgatc cgccatttga aagacgaatc gattatcgca 3256861 tccatggggc acacggatgc cgattccgca ttgctgtcgg atgccgcaaa agcaggggcg 3256921 agccatatga ctcatctgta caacgcgatg agcccgtttc atcaccgaga gcccggagtg 3256981 atcggaacgg cgctggccca tgatgggttt gtgacagagc ttatcgccga tggcattcac 3257041 tcccatcctt tagctgcaaa gcttgctttt ttggcgaaag gcagcagcaa gctcatttta 3257101 attaccgatt ccatgagggc aaaaggactg aaagacggcg tatatgagtt cggcggccaa 3257161 agtgtgacgg taagaggacg aacagcactt ctttcagacg gaacccttgc cggttcgatc 3257221 ctcaaaatga acgaaggcgc acggcatatg cgtgagttta caaattgctc ttggacggat 3257281 atagctaata taacttctga aaacgcggcc aaacagctgg gcatctttga ccgaaaaggc 3257341 agtgtgactg tgggaaaaga tgcagatttg gtgattgtca gcagtgattg cgaggtgatt 3257401 ctcaccattt gccgcggaaa cattgcattt atatccaagg aggctgacca gatatgaaag 3257461 taatggaatg tcaaacgtat gaagagctaa gccaaatagc agccagaata acggcagata 3257521 caatcaaaga aaaacctgat gctgttctcg gtttagcgac gggcggcaca ccggaaggca 3257581 cgtatcgcca gctgatccgc ctgcaccaaa ctgagaatct ctcatttcaa aacatcacta 3257641 cagttaattt ggatgagtac gccggacttt caagcgatga cccgaacagc tatcacttct 3257701 atatgaacga ccgttttttt cagcatatcg acagcaagcc tagccggcat tttattccga 3257761 atggaaatgc agacgatttg gaggccgaat gcagacggta tgaacagcta gtcgattccc 3257821 tcggcgacac tgacattcag cttctcggca tcggccgaaa cggacacatc ggctttaacg 3257881 aaccgggaac gtctttcaag tcgcgaactc atgttgtgac attaaatgag caaacccgcc 3257941 aagcgaatgc cagatatttt ccctccatag acagcgtgcc gaaaaaagca ctgacaatgg 3258001 gaattcaaac gatactctca agcaagcgca ttctgctgct tatttctgga aaaagcaaag 3258061 cggaagctgt tcgtaagctg ttagaaggaa acataagcga agattttccc gcatctgctt 3258121 tgcacctgca ttccgatgtt acggttttga ttgatcgtga agccgcgtca ttaagacctt 3258181 gaaaggaaca tgctgactta tgaatatcaa taaacaatcg cctattccga tttactatca 3258241 gattatggag caattaaaaa cccaaattaa gaacggagag ctgcagccgg atatgcctct 3258301 tccttctgag cgcgaatatg ccgaacaatt cgggatcagc cggatgacag ttcgccaggc 3258361 gctttctaat ttagttaatg aaggcttgct ctatcgcctg aaagggcggg gcacctttgt 3258421 cagcaagcca aaaatggaac aagcacttca agggctgaca agctttaccg aggatatgaa 3258481 aagccgcggg atgacaccgg gcagcaggct cattgattat cagcttattg attcaactga 3258541 ggagctcgcg gctatattag gctgcgggca cccctcctct atccataaaa tcactcgggt 3258601 gcggctggca aatgatattc cgatggcgat tgagtcctca catattccgt ttgagcttgc 3258661 gggtgaattg aacgaatcgc attttcagtc gtcgatctat gatcatattg aaaggtacaa 3258721 cagcataccg atttcccgtg caaaacagga gcttgagcca agcgctgcca ccacggaaga 3258781 agcgaatatt cttggtattc aaaagggagc gcctgtccta ttaattaaac gaacaacata 3258841 tctgcagaac ggaactgctt ttgagcatgc aaaatccgta tacagaggcg accgttatac 3258901 atttgtccac tatatggatc gtctttcata aaaaaagcct ccaacccttt ttaaggattg 3258961 gagacatggc gaaaatcaaa ctggtctggt gccggacgat atgtttcttt tttcgtcttg 3259021 aacttccaga tcggtgattt cgttttgccg ttaaaactgt cttccactat aatgtaccaa 3259081 taataaacag actgcggttc aagatgatcc cagcggaatt cagctgtgtc cccgctcttc 3259141 acttgctccc gttttccgag ctcttcattg gtatatacgt tacattcaaa ataatcggtt 3259201 tccacctttt tgattcttgg cttcaaatca agcgaaaggg aaaattcatc cttgttgcca 3259261 taggtatccg tatcatagta gttcttatcc tttacatacg gagagtacgt cgatacgtgc 3259321 accatgtcat tggcttggtc aaattgaagc aaacgcaaat acccttggcc gccttctggc 3259381 ccgccctgat aatcggccag catttgatgc acaagacgat ccggtttccc atcaccatca 3259441 tcatccagct catctgtttt tctcatcgca ctatgataat gcccgctcaa caccatcacg 3259501 acattcgggt tcggctttac gatttctttg aatattttct ctccgattgg gcttctgttt 3259561 ccgctgacca gcaaatactc atgaaaagct aaaatggcca tccggtcagg atgcttcttc 3259621 agcacctgat tcatccacgc gatgtcttca tccgtaatgc cccatcccat gtacagcatg 3259681 atataatcat tgccgttgct agaaatcagg tcataatgtc cgcggttatt tttataggaa 3259741 ccgccataat gaaatttttt atcaaaacga tcgctgccaa aatatttgcc aaacgccctg 3259801 taggagccgt ccttatgtcc gacatcgtga ttgccggcca gcacgccgta aggaattccg 3259861 ctcttatcca gaacggacat tgaccgatca gcgtttttcc actgtctgat atcggcggaa 3259921 tcatctacaa tatcacccgt gtggaacaca tatttgatat tgagctgctt ttgattatct 3259981 tttatccatt cggtctgttt atcaaaaata tgcggatagc tttcggcgta atactgtgta 3260041 tcagacatcc agacaaatgt gtacatatcc ttcgcaggag gaatttcatc ctgtacaatc 3260101 acattcattt tcgactcccg tacaaaatcg gcggcaatca cagacgcttt cagcgtaaac 3260161 ggtttgtcat ccttcgcgac gaagctgtca acaggctgcc attcgtttgt ccgataattc 3260221 caagcataca tcgtcacctt tctccccggc aaagaactgc ccttccagac tgattctgcc 3260281 agatcattct catcaattga tggatcaacc gtcacttcaa agcgatgata agggaaaagc 3260341 tctttgtttt ctgtcgatac tgtttttcca tcagcagctg atacccgctc caattcttta 3260401 ttcgtaaatg gggtctccct ttccggcaca aagcttttcg gcggttcagt cagtgacgcg 3260461 tgcttaaata ttttcacatg attgcgcgct gtatattgaa atcccctata aaaaccaaca 3260521 tccatggcat cattcgtcgg atctttcacc cgtacagaaa gcttggcctt atgcgtgtcg 3260581 gcttcgctgt ctataacctc cggctggtcc ggatgctctc gttcggtttt aaatatcctc 3260641 tcaatcactg ttttattgcc cgcgagatcc gttgctgtca cttttagaga atgttttccc 3260701 ggcaaaaggt cagaagatga cgtatgatat gggagtgtaa tgctttctcc atctaacgac 3260761 gcctccgctt cctcaattct gctccattta tcatacatat ccgcctgcag gataaggttt 3260821 cctttatacg tttgcccctc ggtgatattc ggctcaatgt gaggtcctga attatctacc 3260881 cgtacaacca ggctgacatt ttccttcccg tcgcttgctt gaatatggtg agcgccttca 3260941 gaaagctttg atgtatccca ctccagcagc tgtgatgtaa atagtccgtc aggcagattg 3261001 aactgaaatt gccagctttt attcgagcgc tgattatcgc caataaagag ttccttctca 3261061 ggagacaccc tctgatctct gatcaccgtt ccatccgata acaccaatcg ggcgtttttg 3261121 actaagaagt catcacggtt ttcagccgta tcaaacggag acaccttcga acctgaacgt 3261181 atcgtaatac gctgcagctg cttccctttc cgaagcagtg tctctggcaa tggaacagaa 3261241 taggtgcggt atttatttgt tgtatcatcg aacaccttca gcactttgcc ttccatcgtt 3261301 accgcgtttt taaaataaag gttcgttttc ctcgtatcga atgcaaaata tacttctttt 3261361 tccatcgcgg gctctgtcac ttgttttttc ccgtcaatcc atagcttaat gctgtcagct 3261421 cgcccttctg tcgtggcttt gagaaattga gttcccgaca gcgtgtctct gttttcaata 3261481 ttcatccgca gaccgtgcgc cttgcttgtt tgtttaatat caatcatttt gaccggcgtt 3261541 ctcgcttcat tgatcccgtc cccggccgcc acataatact ctagctgatc cttcccgatc 3261601 aattcaggcg aatacacaat ataatggaag agattatcgt tgcggtcttt ttcagcaaga 3261661 attcgcttaa acggtttgtt ctcatccgtc cggtagtaaa aggccactgt tttcactagg 3261721 cttcggtccc gtatgtcagc ccgcagctca atgctttcag cagggcggac aggcttgcgg 3261781 tcagtcaaat cctcaatgac cggcttttct ttatcgagct tgattttccg tttctggtcg 3261841 ggcacctgtg cctgtaatac ggttccggga gacggattct tttccccgat tgaaatgttc 3261901 agaagttctg ctgttccgtt cagtggatac ttataaagca ctgatgacag ccggcgcagc 3261961 gcatgtttcc gataatgcgc aaccgaaatg tcctttcctg tattcgttga tatcacaacg 3262021 gcccgcggcc tcgtattggc cataccctct gtctcgtcta tcaccgcaag attttttcct 3262081 tcttttagtt gtgtctgata ataacgattg aaatccgctg acgtcaattc tggatgcccg 3262141 gcaggcttca gccagacgac aaacgtttcg ccggatggta tcaagatcct ttcatcaggt 3262201 ctccaaatca gatcggagtc aggcccttct tttgggtagc ggtaacggat atggtagtct 3262261 ttaaaatcaa tcgttctgtc agtcgtatta aaaatctcaa taaattcata accgtctgcg 3262321 cgtcctatat tcttcgtatc aaccgccagc tctgtgatca gaagctccgg aatatgggca 3262381 aggtcagcct ggtatccttc aagcttcagt ttcttcgtct ccgactcaac ccgctgcttc 3262441 ccattcgaca tcacaatgta atactcaagc tcgctgttcc aaatcaaacg tttcggaatt 3262501 tgtgccaaaa acttgcggac cgctccgggg gtcgggtcca tcggcaccat tttgtagccc 3262561 agctcattac tttgtttata aaaaagaaag gcggaaaatg cttgatacga attatcgcga 3262621 acttgagcct caatcattag attgcttctc atttcagctt tcacatcaat ttgaggagga 3262681 ttttcaagca agggtatgta atgaggcgtt tgaaatagtt cctgctgtac aacaggaaaa 3262741 gctttcgatt catgatggcc gccagacaaa acggaaagaa aagacagtaa tatagaagca 3262801 ataaccgtgt atttcctcat caaagcacct cccttttcat gtattttgcg tctgaacagg 3262861 gaagcttatg agttcatttt tgtgcataaa gaacaaaaaa acgtctgtct cttgaaaatt 3262921 ccactattac ccagtaaact aaggatagtt aaccagttaa caattaaatc agagaggcaa 3262981 attgatggac aacagcattc atgatgaatt atttcaagct atacaacaat tcgcattaaa 3263041 aagggataaa cgcgtctggc aaaaggtgca gataccatcc attggcatat cctcacaaca 3263101 tcacgatcac ctcaaaaaag actggacttt gacccagctt cacattgttt cctgcataca 3263161 taccagccaa aatgtgaaca acagcttctt agcatcccgt ttacacatct caaaagccgc 3263221 tgtttcaaaa gcggttcatg ctttgttgaa acacaatatc attacagtga caaaaaagcc 3263281 tggcaacaaa aaagaaattt tttatacgct aactgatagc ggcagaaaat tggcggcatt 3263341 acatgaacag cttcatgaga aagcaaagga gcaatataaa cagcttttca atgaattttc 3263401 aattgatgat ttaaaaacag tgactgcgtt tttcaacttg tggatcaaat atatgtaaaa 3263461 agagtctcac ccgcatggga gagacctttg gaattctatt atgccccgtc aaacgcaacg 3263521 agaagtgaaa caggtccgcg tgtatacaga ccggactcag cataacaaaa atcttcctct 3263581 aatctgatat tccgcatctt atccagcaca atattagcta caatttcgat ttcgtttttg 3263641 gcaaaagctg ctcctacaca gttatgaatg ccggatccga aagcgagatg ccgggcggcg 3263701 ccgctaaaag cgctcttgat accaagatct tcccgatgaa tattaaacac gtcaggctgt 3263761 tcaaatgctt cagggtcccg gttagccgca ccgatcatac aaaaaacaat cgtatctttt 3263821 ttgatttcca taccgccgac cactgtatct tgggacagct gccgcggaat cagctgaacc 3263881 ggcggtttat aacgcaatgt ctccgcaatg gctctcggaa ctaacgaacg gtcagccaaa 3263941 acatcattca tctgctcagg attgttgagc aaatggtaga tcatcagtgc cagcgtctta 3264001 tcagccggtt ccgttgcggc taacagcaca ttaagaatca gtgcgagtat atccttgtcc 3264061 gacagcgcca tgccttcata ttcagaagta cataggatcg aaattaaatc tgatcccgga 3264121 ttgacgcgac gttctttaat gaccggcatc aagtattggg aaagctgttc gctgcaccat 3264181 aacgaatgtg cccgcgcttc aggagattga gagatactcg tgataaaatc ggcaactccg 3264241 ctgtgccact cagagatttt ttcatggtct cttttatcca gcccgagcat gtccatcgtg 3264301 acgcacaccg caaacgtctt tccaaaatca ttgacgagat cacttttccc tctttcaaga 3264361 taaggcgcta acaagttttc tgcattttgt ttaatcaatg gagacagatg atccagtgcg 3264421 tcaccgataa agcttctcac tacaattctt cttttggcag agtgttcttt tccatgcatt 3264481 tgggccagca cagggcctcg catgactggt tcggcacgct caacaagtga tttcgtcgtg 3264541 aagatatccg gatgctgaag gatatagcgg acatcatgat agcggctgat aaaataactg 3264601 tctatcgact cttcataatg aaccggatct tcctcccgca gttgtgaaaa ataagcatat 3264661 ggattgtttt gaaattgatc agaaagcaca ctaaacaatt taatcgattg gctcatgttt 3264721 tactccccct atcatccttc agatgtgatc cgtttctcag aaagcatctg cgccatttcc 3264781 tgtacaatga gatacccttg attcggccgc atacaaatag aaaattcatg gttactgatc 3264841 ttctcaccca gcttccacgg acgatgataa gcaaggagtg tctcttccac ctctaaaata 3264901 tccggagctc cgataaaaaa cggcagctca gctatgacat attccacagc caaattcagc 3264961 atatcctcac tgacttcttc catcatcaaa ctgacgcccc gcgcacgccc gattatcgct 3265021 tcacgagaca tgtccaaaca agcatgtcga aaatgaggct gctcaaaaaa tgcatgttca 3265081 acttcttgtc tcaacagctg gtaggctttg ttatctataa aatcagaaaa tgtatgaatc 3265141 gccttcggat ccccgccatg agccacaagg gctctttctg caaatctcct gtttcgtgat 3265201 acctctttcc ttacttttcg ttcagccttt cctctcggag ttccaagcgc ttctagaaga 3265261 ttagccgcct catgccctgc aagtaaaact gaaacgcttt taaattgagc tttcgcccat 3265321 ccaattaatc tgtaaatata atcctctgaa aacctgctgt taaatgggct gatccccacc 3265381 aaaacatgcc tgcgccgttc aaatatttct ctgcagtttt ctgttaatgc ctcagcaata 3265441 aaatgcacag accttctttc cgttaccatt ccggtcatct cattcacccc taaaacttat 3265501 cccgctttaa gtcatcaccc tcaaatacaa gatggaatag ctagaacaac tgaacaagac 3265561 gaatggcagg catcacttaa agtttccaaa tgttttttaa gattttaata atcattttca 3265621 atacccatat catgataaat gtttactagt aaacattagt cattttatcc cttttccttc 3265681 caaacgtcaa tatgatctgt gcccaaatat ttgaaaataa atgtaaacat cacattttcc 3265741 acacactttt tacacgcata ttcagcatga catatcaaca aatagtctaa acaccaacaa 3265801 ttgacaacga aaacaagaaa agataaaata aaattgttca ccagtaaacg atttgtttta 3265861 ttgtttcatc gtaaactatt attcctaaga aagaaggtag cctatgtctg atttgacaaa 3265921 acagatgata tacgacatat acgtgagact gctgcacctt aatgaacaaa aagcgaacac 3265981 ttcacttcag caatttttta aggaggccgc agaagaggat gtagctgaaa ttcccaaaaa 3266041 tatgacaagc attcacgtca ttgactgcat cggccagcat gaacccatta ataatgccgg 3266101 aattgccaga aaaatgaact tatcgaaagc gaatgtaacg aaaatcagca caaaactgat 3266161 caaggaagaa ttcattaaca gctatcagct gacagataac aaaaaagaag tttattttaa 3266221 attaacccgt aaaggcagac ggattttcga cttacatgag aaactgcata aaaaaaagga 3266281 gctggctttt taccaattcc tcgattcatt ttcacaagaa gaacaaaagg ctgtattgaa 3266341 gtttctagag cagttgacgt caacacttga agcagaacaa accgatggga ctccagacaa 3266401 acctgtaaag taaacaaaaa ggcggtgtac actttggctc atacaaaatc aaaggcagta 3266461 ttgatcttat acactgtttg cttcagtgca ttttttgcat ctttaagcca gaacatttat 3266521 tcacctattc ttccgatcat taaagaatca ttccatgttt ccacagctat ggtgaacctg 3266581 tcagtctcag tttttatgat tgtgacagca ataatgcaaa ttatattagg agcgatcatt 3266641 gattttaaag gcgctcggat cgtcttgatt accggtattc tggcaacggc agcagccagc 3266701 atcggctgtg cggtgactac tgactttacc ttgtttctga tattcagaat gatacaggca 3266761 gccggttccg cagcactgcc tcttattgct gccacaacga tcggacagct gtttacagga 3266821 aatgaacgcg ggagtgcaat gggaacgtat caaatgctcc tgtctgtcgc accggctatt 3266881 gctccagttc taggaggatt cataggcgga gcagccggat acgaagggat tttttggata 3266941 cttgcggcca tctctatcgt tttgctggtg acaaacagca tcacctttcc taaagattct 3267001 ccaactgaat ctatgcagca agccaaaggc aatgtgttcg ctcattataa atcaatattt 3267061 acaaatcgaa cagggaacgt cattttgact ttaagttttg ttctcttttt catttatttt 3267121 gcagtaattg tctacctccc aatattgctg acagagcatt accatataga tgtgggtata 3267181 gcaggactgt tatatttgcc gctggcgctg agcacgattg caggtacgtt tctgtttaaa 3267241 agaatacagg caaaaatcgg gctgcacacc ttgtttatcg gaagcaatgt gattgccgcc 3267301 tgcagcatca ttttatttgc tgttacacat tccgtttctc tcgttctcat ggctctgacg 3267361 ctggcactgt ttggcatctc gatgggggtt attcctccct tgtactctac aatgattact 3267421 aatgaatttg agcacaacag agggagtgca atcggaatgt ttaactttat ccgatataca 3267481 ggcatggcag caggtccgat ggtatctgcc tacttgctca caatgatgcc gtctgccatg 3267541 tcctttagcc tcctaggcct tggatttgcc gcattgagct tttgccttct tccgccaatg 3267601 ttttcgccgc agaagcgcac gaaacaaaaa aagcaccaca tgtaaaaaag ctgcctttgc 3267661 gggcagcttt ttttattttt ttctaagcgg ctctaaaatg cctttttgaa tcagcaaatg 3267721 gaagaccgac aggataacgg atgcccatat cgctgtgccg aagccgtcga tttgaaagct 3267781 gtcacccata atggacgcgg tcatcataag cgtgatggcg ttaatcacaa acaagaagag 3267841 tccaagcgtc accatggtga ccggcagtgt aaatataatt aaaagcggtt taatcagcac 3267901 gtttaagatc gataaaatga ggctggcgat aatcgctgcc ccaatgctgc tgatatggat 3267961 ggagtcaata tatccatcaa tgacgattaa taacaatgca ttgactaaaa tgctgactgc 3268021 ccattttacc atgtcatttc atatcccttt ctgacgggac gataaaaatc caaatgatat 3268081 aaatgagcaa aaccggcaag acacttgtca taatggctaa gatgacagtt atgactctga 3268141 ggagtgatgc gtcccaattg aaatattccg cgagacctcc gataacaccg gcgattttct 3268201 tatttttttc tgagcgataa agcttattca ttcgatcacc tctgtgagta ctttagtttg 3268261 atggcgcctg ttagtgattc tgagaagacg gtgatgtttt gatcatgtgc ctgatttgaa 3268321 gtgaacatca tttctttttg aatcgtatca tttttttcct tcagcatctc tacatccatt 3268381 aattcatggg acagcgtacc aagattgctt ttcagctctg ccttcactgc gagatcgtcc 3268441 ggaattgcaa gctctacatt tccagtcgtt gtttttgcat aaatggagcg gcagtctgat 3268501 tctgttacgt taatcgcaat atttccgtta aagctttgaa cgtcaatgga ttcgcttttc 3268561 cctcggagat cgatcaatcc gttaatggtt tccgcttcta tcgtaccgca gctgtggctt 3268621 gcgagcttaa tttgcccgtt ggccgtttca gctatggctt tttcggctgt taaatacgag 3268681 aacgacagca cgccgtttgt cgttttcgct gagaactctt ttacatgtaa atgttcccct 3268741 ctgactggac cgttaaacag cttcacccga atcttatcat actccttctg aggaatatac 3268801 aaagtgacat tcgttttcat cgtctttttc tcagtacgga taaaaaactt attacctttg 3268861 atttcacatt caatatgctg aagaaatgcg tgtctcgccg catcctggct gtcagcgcga 3268921 tataccttcg cctggcattc cgctctgata tcgtcatctt cccaagggac gatatttacg 3268981 ctgccattgg caatttgcag ctcaacactg gaaaagtcag tatctttaaa ttgaaaaatg 3269041 tgctgaacat catacgcatg gccaaagttt aaatcaaggt caacttcctt gacctttttc 3269101 acagcagaat caatccagtc aaacagcttg gctcctaaag acggtttgcc gctttctttt 3269161 tttgccgttg taaatggctc ttcctcgtca tgaacgtgaa ctgagagcgc tgtgattttc 3269221 tcttcttttt ccttgtagtc gctgtcaagc ttttcaatca gtgtcaaagc ttcttgtgct 3269281 gtaagctttc cttcctcaac aagcttaagg attcgttcct tttcttgctt cattacgatc 3269341 tcctccccat tgtctactta tgctgcacgc aggaccttaa tgccctgaat cacattccaa 3269401 atgataatgc caatgacaac taagaaataa ataaccgctc ccccgatgat tacaaataca 3269461 ggaagcaagc tgtctccatc aatcgcaacg gctccgccaa gtaaagcaat aaaaaggaac 3269521 agccagccga caaacggaac aatgtgagaa ataagagagc gtatcgcatg gcgttttgtt 3269581 tctttctcat ttacaacaaa atatgcgaca atcggcacaa tgattggcgc aatgaacaca 3269641 ctgaaataac aaagtgatgc aataatagct tgattacggt tcaattcatt ccacactcct 3269701 attgtgaatt gtccatgaca aaagatcagg gacgttttac ttatttatac gtttaaaatc 3269761 tcttcaggtt tcaaattcat tctttagaca tgctccgatt tacggaaatt ggattttaaa 3269821 aagttttaga agtagaatct tccggctata ccgattacaa tatgtaaaaa gcttacggca 3269881 accaaggagg ctggacaagc aatggagaaa gatcccagtg actatacagt aacacaagaa 3269941 tcagtgttaa agctgattca ggaacaaaaa agaatgaatc gtgaaatgat caccgagctt 3270001 gagcagattc acggaccctt cccgatctct cacgatatcc aatatataaa agtgctgctc 3270061 gacagcagca acacacatat tgttcaagat ttaatgagtg taagtaagca gctgtataag 3270121 aagactttgt aattgcggaa aacatatcat tcattataac tgaaacaaag ctaaaggtta 3270181 gatgacaata tcttgccttt tttgttttga aaaaacaagt gattccctgg ctgtcacaaa 3270241 atgattgtaa caaaaaaagc ctgccggcac atccagttaa tggactctgt cggcaagctg 3270301 taactatcag aaagagatag ccgttcaaaa ttaacgtaac aattgaagca cgttttgcgg 3270361 ctgttggttt gcttgagcaa gcatcgcttg agaagcttga gaaggaatgt tgttctttgt 3270421 gaactcgctc atttctttcg ccatgtcaac gtcacggata cgggactcag cagctgtcag 3270481 gttttcagaa gaagcaccaa ggttgttgat tgtgtgctct agacggtttt gtaccgcacc 3270541 aagtttagca cgttggtttg agacattgtt gattgcagta tcaatacttt caagttgtgt 3270601 atcaaaagga gtattagcaa aatctgttac attaagtgcg tttactccta aagcagttga 3270661 tgacatgctg tcaatgttaa ctgtaagctg ctggccagca tttgctccaa tttggaaagt 3270721 gaaaccatca gtttcagtac catctaataa ctttttgccg ttgaattcag tacgatttga 3270781 aatgccatca acttcctcaa taagcgcatc catttcatct ttaattgcac caagatcttc 3270841 tgcttgttgt gtacctgtgt ttcctgcttg aacagtaagt tcacttctaa acctattatg 3270901 ccgtaaagaa aaagcttgcc tgctaagccc aaggatggac ttgccgacaa gctgtcccct 3270961 cttaacagag ggttttaaga tgtagctgtt tcttttgctt tcaagagcga tttcatgcgt 3271021 gttttgtcac gttcgataac aggctttaaa taacggcctg tatacgattc ttcaacttca 3271081 gtgatttcct caggcgttcc agacgcgaca atggttccgc ctccggctcc gccttccggg 3271141 cccaaatcca caatgtaatc ggccgtctta atgatatcaa gattgtgctc aataaccagt 3271201 acagtgtctc cgttgtctac caaccgttgc agcacgacaa gaagcctggc gatatcgtcg 3271261 acatgcaaac ctgtcgtcgg ctcatctaaa atgtagagcg tacgtccggt tgagcgtttg 3271321 tgcagctctg acgcgagctt cacgcgctgc gcttctccgc ctgacaaggt cgtcgccggc 3271381 tggccgagcg taatataacc taaaccaaca tcataaaggg tttggagctt gcgtttgatt 3271441 ttcgggatat tttcaaagaa agaaagagca tcttcaaccg tcatatcaag cacatcagag 3271501 atgctttttc ctttgtacgt cacttcaagc gtttcacggt tatagcgttt gccgtgacac 3271561 acctcgcatg gaacgtatac gtcaggaagg aagtgcattt caattttaat aatcccgtct 3271621 ccgcggcagg cttcacatcg tccgcccttc acgttgaagc tgaaacggcc ttttttatag 3271681 ccgcggacct tcgcttcatt tgtctgcgcg aatacatcac gaatgtcatc aaatacaccg 3271741 gtgtatgtcg cagggttgga tctcggcgtt cttccgattg gcgcctggtc aatgtcaatg 3271801 actttatcta aatgatccaa acctttaatc tctttatggc tgccgggctt cgctttcgct 3271861 ttatgaagct tttgcgccag cgccttatgc aaaatttcat taacgagtgt actctttcct 3271921 gaaccggaaa cacctgtaac tgctgtaaac gtcccaagcg ggaacttggc attcactttt 3271981 ttcaggttgt tttctgatgc acctttaatt tcaatgtaac gtccgtccgg ctttcttctt 3272041 tcaggaggca atgggataaa ctttttccct gataaatagc tgcccgttaa tgaatttgga 3272101 tcttccatca cttcttccgg cgtacccgca gatatcacct gtccgccgtg aatgccggct 3272161 cccggtccaa tatctattaa ataatctgct gccatcatcg tgtcctcatc atgttcgaca 3272221 acaatcagcg tgttcccgag gtctctcata tttttcagag cgctgatcaa gcggtcgtta 3272281 tcacgctgat gcagaccgat agacggctca tctaaaatat aaagcacacc ggataaacgc 3272341 gagccaattt gagtcgccag cctgatgcgc tgcgcctctc ctccggacaa tgtacccgct 3272401 gccctgctca atgtcaggta atcgaggccg actttgtcca gaaagcttaa gcgctccaca 3272461 atttcgcgca aaatcaaatt ggcgatctgc atatccttct cagaaagggt aagatcttta 3272521 aagaaggcaa gtgcgtcggc gacagacagc tcggtaattt tcccaatgtg gcggccgtca 3272581 atcagtacgg caagcgcctc tttctttaac cgatagcctt tgcacgtcgg acaagacttc 3272641 tgagacatat actgctccat ttgctcacgt atgaaatcgg agcctgtctc cttatagcgt 3272701 ctttcaatgt tgcgcaatac gccttcaaat tgaatttcac cttcgcggat ttgtccaaaa 3272761 tcattttcat atcggaaata aatcaggtca tccccgctgc cgtacagcac tttatccagt 3272821 tgatgcttcg gcaaatcttt gaccggcaca tccatatcaa tcccgtagtg ggtgcagact 3272881 gcctcaagca gctgaggata atattgtgag ctgatcggtg tccaaggggc gaccgcattc 3272941 tccttcaatg acaaatcttg attggggatg acaagatcgg catccacttc aagcttcatt 3273001 ccgagaccgt cacacgtcgg acacgccccg aacggactgt taaacgaaaa cagacgcggc 3273061 tcaagctcac caattgaaaa tccgcagtgc ggacaggcat gatgctcgct gaacatcagc 3273121 tcttcctcac cgatgacatc gatcataacc cgtccttcac ctaaacgaag cgccgtttcc 3273181 aatgaatctg acagccgggc tgccacgcct tctttcacga caatccggtc aatgactacc 3273241 tcaatggaat gcttcttgtt cttttctaat tcgatatcgt cggaaagctc agccatctcg 3273301 ccgtcaattc tgactctgac atagccttgt ttcctaatct gttcaagcac tttgacatga 3273361 gcgccttttc ggcccgagac aatcggcgcc agcacctgaa gcttcgtccg ttccgggtat 3273421 tccagaattc tgtccaccat ttgctcgatg gtctgggatg taatctcaat tccgtgttcc 3273481 ggacaatgag gcttccctac tctcgcatat aaaagacgca gataatcata aatctcagtt 3273541 accgtaccga cagtagacct cggattgcgg ctcgttgttt tctgatcaat gctgatggcg 3273601 ggagagagcc cctcaattgc atccacatcc ggcttatcca tttgccctaa aaactggcgg 3273661 gcataggcag acagcgactc gacataccgt ctctgtcctt cagcatatat cgtgtcaaag 3273721 gcaagggagg atttacctga tccggacaaa cccgtgacaa cgacaagctg atctctcgga 3273781 atcgttacat ctatattttt caggttatgc gccctggctc ccttcacctc tatccgatcc 3273841 atagccattt gttcatcatc cttccgcttt tagctctaaa agtaaatcgc gaagctccgc 3273901 ggctctctca aagtcaagcg ccttggcggc ttccttcatt tcatgctcca tctgttcaac 3273961 gactttctgg cgttctttct tcgtcatttt cgacagcttc ggcgcggctt ttgttttgta 3274021 ttccgcttta tcctcagctg ctactgtggc acgaatgaca tcgcgaattt ctttatttat 3274081 cgttttcggc gtaatgccgt gctcttcgtt aaaccgctcc tgctgctcgc ggcggcgttt 3274141 tgtttcatta atcgcaattt ccatagactt cgttatttta tcggcgtaca taatgacgcg 3274201 gccttccgca tttctcgctg cccgtccgat ggtctggatc agcgaccgct ccgaacgaag 3274261 gaaaccttcc ttatccgcat ccaaaatcgc aacaagggat acttcgggaa tgtccaaacc 3274321 ttccctcagc aggttgatgc cgacaagcac atcgtacttg ccaaggcgca ggtcgcggat 3274381 aatttcaatc cgttcaagcg tcttgatctc agaatgcaga tagtttactt taatgccgat 3274441 ttcctttaaa taatcggtca gatcctctga catcttcttc gtcaaagttg tcacaagcac 3274501 ccgttcattc cgctcgattc ttgcttgaat ttcgccgatc aagtcgtcaa tctgaccttc 3274561 gattggacgg acgtcaataa gcgggtcaag aagccccgtc ggacgaatga tctgttcgac 3274621 catttcatct gtatgttcaa tctcgtacgg ccctggtgtt gctgatacat acacgatatt 3274681 gtgcatatgc ttttcaaatt cctcaaaacg aagcggacgg ttatcaagcg ctgatggaag 3274741 ccggaagccg tgatccacga gcacctgttt ccgcgcctgg tctccgttaa acatgccgcg 3274801 cacctgagga attgtcacat gcgactcatc caccacgatc ataaaatcgt ctgggaaata 3274861 atcaagaagc gtatacggcg ttgaacctgg aggccgcaga gtcaaatgtc ttgaatagtt 3274921 ctcgatgccg gagcagaaac ccatttcacg catcatttca agatcatatc ttgtccgctg 3274981 ctctaaacgc tgcgcttcaa ggagctttcc gttttcatgc atgaccttca gctgctcctc 3275041 aagctccttc tcgatatttt gaatcgcctt ctccattttc tcggcccgcg ttacgaagtg 3275101 ggatgccggg aaaatcgcaa catgatctcg gtcgccgaga atttctcctg tcagcgcatc 3275161 tacttcccga atccgttcga tttcgtcacc gaaaaattca actctgacac aatgctcatc 3275221 acgggatgcc ggaaagattt ccactacatc cccgcgcaca cgaaatgtac cgcgctgaaa 3275281 gtcgatatcg ttgcgggcat attggatgtc tacaagtttt ctgagcagct cgttgcgctc 3275341 aatttccatt tcagtccgca gtgacacgac catttcccgg tattcctcag gcgaaccgag 3275401 gccgtatata caagacacac tcgcaataat aatgacatct ctgcgctcaa acaaagctga 3275461 tgtggcggag tgtctcagtt tatcaatttc atcattaata ctagcgtctt tctctataaa 3275521 tgtatccgtt tgaggcacat acgcctccgg ctgataataa tcatagtagc tgacaaaata 3275581 ctcgacagca ttgttcggaa aaaattcctt gaactcactg taaagctgtc cagcaagggt 3275641 tttgttatgg gcaatcacga gagtcggctt attgacttct ttaatcaaat tggacaccgt 3275701 aaatgttttc ccagttcctg ttgcacccag cagagtctga tgcttcttgc cctcctgaat 3275761 tcctttcaca agcttttcaa tggctttcgg ctgatctccc tggggctgat atttcgagac 3275821 taactcaaag cgatctttca caaaaataag cctccgtttc tttaacgaaa tcttcctata 3275881 gatatagtaa cacaatggaa agcaaaatca ctaaaaatac gaactaaagt tcggtggttt 3275941 tttatttcca gctgtttttg tgtataaaaa acctgctttt aaaacgtaaa agcaggtatt 3276001 cagtctttat attcattatg tccgatttat tcttcttttt tctctgcagc ttttttggcc 3276061 atatacagtc cgccagccac aagagacaca acatccaatc ctacaataaa atacgtttct 3276121 gtatagcctt ttaaataaga ggcaaacagc aatgcagctg ttaaagcgat cgccacataa 3276181 tgattaaagg tgactctagt aaatagaaca acaagcataa aagggaaaaa caatgcaaaa 3276241 acggcttttg taatcaacaa aaaccctcct cagggattct tcatctgatc tgattatagt 3276301 aaaaaatgaa gaatcggaca atcgtgcatt cgctccctct acttacacca tacccctttt 3276361 cagccaaaat caatcaccat atttgcattt tggtgccggt caaaacttat tccatggtgc 3276421 cgctgttcta atcagcggca ctttttttat tacatcatca agtccgccgc cagattccga 3276481 gaataaaaga aaataggcat acagtaccag tacggccgca tttttcagga taatataacc 3276541 aacttaacta ttcattttat ttaggacttt ctgcgtttga cagcattttc ctgaaaacct 3276601 acaattaaat gatagtgttt actatcattt tttaaacaca ggctccgcaa taaaaagact 3276661 agagagaaaa acaaaatgaa tgaagaaaag aggggtttca aatatgtatt ctgttttatt 3276721 tcgccaggca gaagagtcca gccagctggc tggagcaaaa ggaatgaatt tgattaaatt 3276781 gaccaaacac ggtcttcctg ttccggacgg gtttattatt caaacgaatg cgctcgcacg 3276841 ttttatggag gacaaccagc ttcaagagac tagtgaaaac gtcgaaggcg ggatcatttc 3276901 cggaacattt tcggatgagc tgaaagatga gctgactagt tccttttata agcttagaga 3276961 atcatatcga tccgtagccg tgcgttcttc gtctgcttcg gaagatttag aaggcgcctc 3277021 attcgcgggt caatatgaaa cctacttaaa tatcaaaaca gaggaagagt ttctggctaa 3277081 agtgaaagaa tgctgggcct catttttttc tgggcgggtc agcagctata agaaaaaaat 3277141 gaacaatcaa atcgcagagc cgttaatggg aatagtcgtt caggggctga tcgattcaga 3277201 aatgtcaggt gttatcttca gccgcaaccc tgttacccat gatgatagag agcttttaat 3277261 cagcgccagc tacgggttgg gtgaagctgt tgtttcagga aatgttaccc cagacacgtt 3277321 cattgttaat aaatcttcgt ttgagattca gaaagaaata ggtgcaaagg aaatctacat 3277381 ggagtctgcg gcagaaggaa ttgctgaaaa agaaacgagt gaagacatgc gcagccgttt 3277441 ttgccttaca gatgaacaag tgattgaatt ggctgaaatc acaaaaaaaa ccgaagacct 3277501 gtacggatat cctgttgata tagaatttgg aattgctgat catcaaatat accttctgca 3277561 agctcgcccg attacaacca ttgatcagga caaaaaagcg gcagaagaaa aacgcagctt 3277621 catgattacc gacactgata tgaatgattt ctggcttaac atggagtcta atattgaagg 3277681 tccggtgagt ccgttatttt catccttcat cgtgccggca ttggaatatg gcttgaagaa 3277741 gagcatgcaa aagtttccga ttggtgtagt tgttgatgaa gtaaaacttt atcgcggaca 3277801 tatttattcc aaaaaccaag gcggacagca gcctccttct gaagactgcg gcaaagagct 3277861 tttcccgatt ttatcggagc atatgtatga catcatcaat cacacatacc tcccttttta 3277921 ccggacactg gaccagctcg cacaaactga gcataccgca gaaagcgcac tggaagcttt 3277981 tcaaaaacta aaggcctttt atctcacggc ttatgaagag cactttaata tcgttttccc 3278041 gcaaatcctt ttaacaaaca aactgcaagc gatgtatcag gacattcaag gagagtccga 3278101 aaacgctcat ttttacgaga tgctgacagg aaaaatgaac aaatcactgg aaacggaccg 3278161 ttgcttatgg ctattttctg tggaagttca ggagaacccg aaccttctgg ccatttttga 3278221 aaacaacaag cctgaacagc tccaggagaa attggaacaa acagatgagg gaagacactt 3278281 cctgaagaac gtccatgaat tcttgcaaga atacggatgg agatctgtta aaagtcatga 3278341 tctgattgaa caaatctggg tggaaaatcc gtatttcgct ctggccaata ttcaaaatta 3278401 tgtccgtaat ggctatcatt ttgacaatga atttcagaaa acaaaagaaa aacgagagaa 3278461 attatacaat gaattcttgg aaagcataga agatcccggt ttacgcaccg aatttgaccg 3278521 ctattatcaa tggacactga actctgcaaa tataaaagat gatcaccact tttatattga 3278581 cgccatgctg gatgccaagg cgagaatctt tctgctgaag ataggtgaat tgctggcgga 3278641 aaacggtgtc attcaagatc gggaggacct ttggttctta tatgacgacg aagtggaaca 3278701 agcgcttctt caccctgtat ccctgcaaga aaaggctgaa aaacgcagac agatttttca 3278761 tgagtatgag ctggcccaag ccccggccta cctcggcacc ccgacaaaag aacagctcaa 3278821 agcagctgaa gaaattgtcg gcgctgtgat agaggatgaa aaaaacacag agaatcatat 3278881 ttttggcatt gcggcatcaa gcggcattgc gacaggtccg gtgaaaatca ttcgggacgc 3278941 caatgaattt tctcaattcg cgcctggaga cgtactcgtt tgcaagatga ccacaccgct 3279001 atggaccagc ctgtttcaag acgccaaagc gattattaca gacacaggcg gcattttgtc 3279061 tcacgctgcg attattgccc gtgaatacgg cattccagcc gttctcggca cacgcacggc 3279121 aaccgaaaga ctgcgagacg gtgacatcat cactgttgac ggaagcagcg gcaaaatcac 3279181 agttgtcagc cggtcctgat gcgtccccct ctttcttata caagcggggc gggtgtatac 3279241 ttgtcctgcc agtatattcg tgaggtgaaa cgtattgaga ccgacaaaca agagaatcct 3279301 tgatgctgcc atgcagctgc tcgtcaaaaa aggatatcgc gcaacgacta caaaagaaat 3279361 tgcagaaaaa gcaaatgtaa gtgaagcgac gattttcagg aactttaaaa acaaacaagg 3279421 actagttgag gctttgcttt ctcagcattc ttcaaacaga ggcagcattt tggaacaaac 3279481 agaaggggat ttgtacaaag acctgcttca tatcggaacc tgtctcttgg aggagctcga 3279541 acatagaaaa gatatcatta aaatcagctt tcgtgaaccg gccatgtttc aggatgtcat 3279601 taaccacgtc actgaatatc cccaatctat gaaacagcta ttggttgatt atctcaaaac 3279661 gatgggtgag aaaggggtta ttcagacagg aaatgaagcg gaacatgccg acgtgttcat 3279721 gtcgattatc ttcggttatt tcattcaccg tctccactta ggagaccggg tcatatcaat 3279781 gccccaggaa aaaatgctgg agcatagcac agctctattt gtcaaaggaa tttctgctga 3279841 ttaactcctt ggcataataa aaaggaggat cccaatgagc tcaagaaaag aatgggcgct 3279901 gatcgtctcg ctattattgg gggccattct ggttcccatt aactcaacga tgatcgcggt 3279961 cgcgctctca tctatttccc atacgtataa cgagtccatc gcaagcatca cttgggtggt 3280021 taccgtttat ttaatcgtga tggcagtcac acagccgatt gcaggaaagc tcggtgacat 3280081 gtacggcaat aaaacaatgt acttatgggg agtcggcctt tttctaatcg catctctagg 3280141 ctgcgccctt tcaccgagtc tgctcctgtt aattgtcttt cgggcattgc aggctgtcgg 3280201 cggggcattg cttacgccaa acagcattgc cattatccgg catgttgttt ctgaaaaacg 3280261 cctaccgaaa gtgtttggat ttttcggact gggcgcggga cttggtgcag cactcgggcc 3280321 ttttatcggc tctatactga ttgacagctt cagctggcat tcgatttttt gggtcaacat 3280381 cccgttcctc gccattgctt tatttacggc attaacgatg tttcctcaat ataaagaaaa 3280441 taaatctgac gcgccgctgg atatcatcgg ctctctcttg cttgcaggca gcatcgtttc 3280501 cattatcctg ctgacgaaaa atgaggctcc atggggatat actgtataca gtgtattgat 3280561 acttcttttt gttccgcttt ttttcagaag agaaaaacgt acccagcacc ccatcattga 3280621 ctttgcactg tttaaaagct caacctttac aaatgcgaat ctatcagtct tgttaagcaa 3280681 tttgatgatg tatgccgtct tattgattat gccgttattt atgacgaacc aatttgggct 3280741 taatacatct aacagcggga tggcgctttc tgtattttcg atcttcatgt cagccagcaa 3280801 ctgggtgggc gcgcagctcc atcacaaatg gggagccaaa aaaatcattt ttctttcatt 3280861 tgccatgatg gctggtgcga atctattatt tttgctgtta agcagctcgc attctgtctt 3280921 gttcctcatg ctctctctta tccttggcgg gctcgcttcc ggagtcggtc tgaccagcat 3280981 gcaggtttca tcccttgcca cagtagaccc cggtatgtca ggagtggcat ctgggatttt 3281041 ctcgaccttc cgttatttcg gaagcatcat ttcatcagcc ttaattggcc tgatttcggg 3281101 atatcacacc ctatttatga ttctctttgc tgtatccatc atcggcgttt ttgtttcatt 3281161 gggcatcaaa tctgatgaaa cggcacggat agaaaaaaac tcagcgtaac acaaaacagc 3281221 ccggcatcgc atcatcctgc ggtgccgggc tgccttttat gatcccgaag cgactgcttc 3281281 gtcttcacgg tcatccttta cgaagaggat gcccaattca tgatgttctc cttcataaga 3281341 agctcgctgg tcaaaacgaa tttctccatt caaaccgata atttcaagct ttacatatgc 3281401 acggttatgc tgaagcgctt catagaaatc agaaacgttc ttaaccggta tgccattgac 3281461 tttcgttatg atttccccga ttttcaattc cagatcctca gccggcgtat tggggataat 3281521 cccaagcacc attaagccct gatccctttt cgagaaataa aacggagccg cgttatcatt 3281581 cactctttgc tttatggaca gaaaaatacg ccctaacaaa gcggtacaga ccgctgcacc 3281641 cgcaagcggc gtccacagta agctcgctgc accgagaact gcgacggcaa gaccgagaat 3281701 acaaacgcgt ttcgctgtga tccttatact cgtttcaggc agcgatccct gtaccctttg 3281761 tccaaatccg acaaagtaag gaatccatag aaaatggaat gagccgccgg gaaccgtaaa 3281821 cacgggccac cagctaaggt gcgattctaa accattaccg ggcacgagaa ggaacagcgg 3281881 caaaagccaa acccggtttg ccagctgctg tccgatcggc aaaccgcggc tgcttacgac 3281941 aagtgccggt gatgttctca catgcgcaga acgataagca accgctcctt cagtgataat 3282001 cagcaaacct agaaacacag ccacagccgg ccaaacaact gcaaatcctt gcggaaatct 3282061 ctccagaaag ggctccgcct gatatatttg cagtccaaaa cctatcagca tactcacact 3282121 gacgatatat gcagcagaca tccagtttgc gcgaagagtg aacgctgccg ctgcagtgat 3282181 aacggcaata atcgcaagta aaccgagagg aatcgatatt ccgagtccac ctaaaataac 3282241 tgacaaaaga agacctggaa tcagtccctt tgtatatgta aatttcagat catcataaat 3282301 atctgctatt cttgtatgaa aggtttttcg ttcccgtttg attcttacat agccgaaagc 3282361 caaggttatg atgataaaaa accagaaaag cgggtgtaag aagaacaagc ccgcgctttt 3282421 taacagttca attccccatt gaacagacac tatctctcac cgcctcaagc caaacatgtt 3282481 actcatattc tatcaaatat taaatggctt ggatatcctc aggagagttt atctctcttg 3282541 cgtcatccac agcgtgacat tcgatagtga aaaatccttt aaatagtggt ttacatccac 3282601 atccaataac ccgctgatta gatgcatcga cctttttata tctgtcagat taattcctaa 3282661 tcgcttatgg tttttcatta agtagttaaa ataatgtttg gcgcattcct cattaatgtc 3282721 atttactgat tcgacattgg tgtaattgac caaatatctg ctgaacagca taagaagact 3282781 tagtgctttt gtagctgaaa atgttacgtc ttgtgttctg tcttttaatt gttccactaa 3282841 ttcataatat ttttttttca cgcacaatac ttgccctctt caattgtgaa cccccatttt 3282901 ctttatacag ataagcacgg gccagtataa gcagcagtac tggagtgcta acaagcattc 3282961 tcgctaacgt tactctttaa atacctgtcg ttcagctgcc attaacctga ttactgttct 3283021 ttttagaacc ttcttatatt gtatgaagta aacaaagact aggcaacttg caaaagtttc 3283081 attttaaatg catattaact cgttagaaag tctctctcat atattgatat cgggtaataa 3283141 cagtccttta taaatgttta tttgtgaaaa tttttttaat ttcttgtcaa aaactcattt 3283201 tttatgtgac ttatgatcca taatctcttt aagcacaaag aaacaggaga tgaaatacca 3283261 tctcctttaa ttgacaaata atgatttcaa tgctgtttga agctgcaaat catttttttc 3283321 atctgatttt ttcttttcta tctgctgatt taatgtctct gcagtgcgag tgtcgatcac 3283381 accggtttta ttcagcttgt tttgatcctg aaaagccata accgcttttt tcatgtcttt 3283441 gctgaaatag ccatcctcac gtcccggatc aaagctgaga ccttttaaca atacctgcgc 3283501 atgcttgacg tcttcattgt tcatgtccac tttaagcggc tctttcagct gtaagggccc 3283561 ggcggaaaaa taatcgggct gcttaatcgc aatggtcggt tcaattcctt tcttatgaat 3283621 ccagtttcca tttggcgtca gccacttgta aagcgttaat ttgatgttgc tgccgtcccc 3283681 cattggcaca gcctgttgaa ccgttccctt tccaaaagac gtatcgccta caacatcata 3283741 atggccagct tcctttaatg cgccggcaag aatttctgat gcagaggcac ttcctttatc 3283801 cgtaatcaca ttgacagggt acgctttttt atgggtcaat gttgaaaaat aacgtttttt 3283861 atctccattg cgttcagcaa tctgaatata cggctgatcc tttgtaacga aatgcttaag 3283921 aatttcttcc acactttgaa gatatccacc cgggttgccg cgtacatcaa tgacaagtcc 3283981 ttctatttct tttttctcaa gctccctcag cgcttttgca aaatcctctg cggtgtgctc 3284041 agaaaaagta gagatggcaa tatatccgac agaatgcccc tgtacttttt tctctgatgc 3284101 aaaaaccgtt tcgagcggaa tctcagctct cttgatccgg aatgacaact gcttcttcgt 3284161 tccaggccgc tgaatcttca ttgaaacgct ggaccctttt tttcctctta tttttaacac 3284221 agcgtggttt aaatccttgc cggccatcga ttctccattg atgctgataa tttcatcatt 3284281 aggcttcaac ccggcttttt ccgctggcga tttcttgaat ggagaaacaa taataatttt 3284341 gccgtcttcc attccaacct cagccccgat gccttcaaat gaggaatcaa gagaatcaga 3284401 aaattgctta gctgtctgct tgtccatgta aacagaataa ggatcattta gcgtagacag 3284461 cattccctgg atggctccct cgagcagctt ttctctatct actttttcta cgtactcatt 3284521 cgaaattaac tcatacgctt tttcgatttt gtccatagct ttatcccgtt cagagtcagc 3284581 ttgtgccgtc gcgggaactg ctgcagtctg gggcttatcc atctcaagca ggttgattcc 3284641 cgcatataca ccggcgcctc cgaacagcat gctccctgct gctatcacag ccattatttt 3284701 ttgattcatc ctttactcct cctgtatgcc agactgtctt taccaaaacc tagagatagt 3284761 atatgtaaag gatggagatt tcatgtaatc atagaagaaa aagaaggcaa atgaaaagcc 3284821 gtcccgaaaa cggaacggct ttttcacttt atactcgcag aaacttgcgg atggaagtca 3284881 gacttcccca tactccaatt actgcgccga ttgcaatcag cactagcgaa acttggaata 3284941 caaatggatt ataaggaaga agagagacaa atgatccttg aacctttgga acgacccatc 3285001 cgatgacgta ttggtaagtg ctcagcacca gtgcaatcgg aatcacagaa ccgaatacgc 3285061 ctagcagcaa tccttcaagg aaaaacggcc agcggataaa ccagtttgtc gcgccgacaa 3285121 gcttcatgat ttcaatttct tttcttcttg cgaaaattgt aattttaatg gtgttggaaa 3285181 ttaagaacat cgccgtaaat accaggccga taattaacgc gattccgatg ttgcgggaaa 3285241 cgccgaccac tttaaacaaa cggctgacct cttcttttcc ataagtgact ttataaacat 3285301 gatccatttt ttcgatcttt ttcgccacgt tcggcgtatc atgcggatct gtcgttttga 3285361 cgacaaacgc atcattaagc gggttttcct gatccttcat tgtcagggat tttccgctgt 3285421 caccaaaact gtcaaccagc tggtcaagct ctttttcttt agatgaaaaa gtgacactct 3285481 gaatgccctt cagttcctta atatcgttct gaagcttgtc ctgtgccttc tgatctgcag 3285541 tcagatcaat cagcactttg atttcgactt gtttttctgc attcgtggcc atgttattca 3285601 aattcagcat aatcactaaa aacacgccga ctaaaatcag cgtaacggtt acagcactaa 3285661 tggatgcaaa tgtcatccat gtgtttctcc cgagagattt aaaactctca cgcaagtggc 3285721 gcccgagaat tttaatcata tgaaccatac tcccctcttg actcatcacg cacaatgata 3285781 ccatcttcga ttgcaatgac acgtttcttc atggtgttta cgatttcttt attatgtgtc 3285841 gccatcacga ctgttgtccc gcggttgtta atttcctcca gcgtcttcat gacttcccag 3285901 gacgtatccg gatcaaggtt tcctgtcggt tcatcagcaa tgacaacatc agggttgttc 3285961 acaattgatc tggcaataga tacacgctgc tgctccccgc ctgaaagctg gtcaggaaat 3286021 tgtcgcgctt tatgcttcag ctgcacgaga tcaagcactt caagcacccg tttcttaatg 3286081 acagacggct gttctccaat cacttcaagg gcaaatgcca cattttcaaa aacagtaagt 3286141 ttcggaagaa gcttgaaatc ctgaaagaca acacctattt tgcggcgcac gaaaggaatc 3286201 tctttttctt taattgtcgc gagatcttta tgattgatta aaatttgtcc ttttgtcggt 3286261 ttttcttctc tgtaaatcat tttaataaaa gtagatttac ctgctccgct cggaccaaca 3286321 acatacacaa actcgccggg atgaatggta acagaaatcc cattgagtgc ttttacgccg 3286381 ttcggatagg ctttatatac ttccttcatc tctatcatga aatcacctaa tcttttatat 3286441 cattttatct atcacacggt catactcttc gaatgcattc gacaatttat gacccattca 3286501 tttgtaaaaa gatgaaaaat ctgaaagttc cctttttcaa tacacttcat tatacgtcaa 3286561 atttagacat aatactatta cagtttcttt tcattcatat tgtcaaggca taaaaacatc 3286621 cttgccagca ctcggcaagg atgtttttat cttacttttt ttctgacagc catttggcaa 3286681 taacagcggc ttcgttatca tctacaagcc cctttggcat attgccgcgg ccgtttttaa 3286741 taatgctttc aattttgtgt tcatcgtatt tgcctccgac ctcttggaga ttaggccctg 3286801 acacaccttc taaatccttg ccgtggcagc ctacgcagct ttgctgatat aattcttccc 3286861 cttcagatgc agtggcttcc gtcttgctgc cagtgtctgt cttctcttct tttgcatcgt 3286921 ttgatccgca ggcagccaac agaacagaaa gcgcaaatcc aatcattagt atcgataact 3286981 ttgatttcat gttgagaagc acaactcctt tacgatctct tccatattat aacctcgttt 3287041 aagcgcgttt gaaaccctcg cccagcacct cgctcgcgtc tgctacaatt acaaaagctg 3287101 actcatcaat ctgtttgacg atttgtttca atttggtgaa ttcagtttgc ccaaccacgc 3287161 acattaaaat cggacggtca tcgtcagtat atccgccgac tgcagaaatt tttgtcacgc 3287221 ctctgtcaat cttctgtaag acagcctcct tgacagcctg ctcctgcttt gtaatgatga 3287281 gcgccatttt tgaacgatta aagccgactt gcacaacatc aatggttttg ctggacacat 3287341 agacgccaag catggcatat aagccttgct caatattaaa tacaatcata gccgtaacaa 3287401 cgatcattcc gtcaatgatg gcgagacact tccccaatga cagaccggag tacttatgaa 3287461 tgatctgtgc agccaaggct gtacctcccg tcgaaccttt ccctaagtac acaataccaa 3287521 ttccgatacc tatcccgaca ccgccaaaaa tcgccgccag gagttcatga tgagtggcgg 3287581 gctgaatatc ccttgtcaga aacactacta gcggcaaaaa cacagaacct gcaagcgtct 3287641 ttagtccaaa tttcccgccg agcaaaatga cgccagcaat aaataaaggg atattaataa 3287701 tccactgtac atacgctgct tcaaaaccat atgattgtaa aatcgtactg atcccgctga 3287761 ccccgccggc ggcaatctta ttcggaagca aaaatacatt aaaggacacg gccgtaatcg 3287821 ctgctcctat caatatgtat acataatccc gcaaaatcca caatgtttta ttccgtacgt 3287881 ccatcatata tcctccgttt cttccaatgc tctccgatag cattttaatc cttccctgat 3287941 tagatgtaaa taacacccaa atacagtggt aatatgctaa agcagcagtg aaatcaagga 3288001 tataagaaat aaaaaaacac acccgtatgc atcaggtgtg tttttcagct tatgaaagct 3288061 tagaacgcag gtaggcatca ataaacgtat caatgtcacc atccattaca gcttgaacgt 3288121 tccccatttc tgtattggtc cgatggtctt ttaccatgga atacggatgg aatacataag 3288181 aacggatttg gctgccccag ccgatttctt tttgttcacc gcgaatttca tccagctctg 3288241 cctgctgctc ttcaattctg cgctgataca gcttggcctt cagcattttc atggctcttt 3288301 cacggttttt aatttgtgag cgctccgttt ggcatgtcac aactacgttc gtcggcaagt 3288361 gagtaatccg aacggctgaa tccgtcgtat tgacgtgctg tccgcccgcg ccgcttgcac 3288421 ggtacgtgtc aactttaata tcctccgtac gaatatcaat atcaatttca tcgttaaatt 3288481 caggcatgac ttcacatgaa acgaaagatg tgtggcggcg gcctgatgaa tcaaatggtg 3288541 agatccgcac aagacgatga acaccttttt ctgctttgag atacccgtaa gcgttgtgtc 3288601 ctttgatgag caatgtcact gacttgattc ccgcctcgtc acctggaagg taatcgagag 3288661 tctctacttt aaagccgcgg cgctctcccc atcttgtata cattctaaga agcatagagc 3288721 cccagtcctg tgactctgta ccgccagcac cagggtgcag ttctaaaatc gcgttatttt 3288781 tatcatacgg ctcgctgaga agaagctgaa gctcaaactc attgaactct tttgttaatg 3288841 actttagttc tttttcaagc tcaagctgga gatcagtgtc cggctcttct ttcaaaagat 3288901 catgagtcat ttgtaattct tcgtgggatt cattcaattt tttatacgaa ttgacataat 3288961 cctttaaacc gtttgcttca tttataaccg tttgagcttt ttgctgatca ttccagaatt 3289021 ccggatcagc catttgttca tctagctcag caatgcgggc ctcctttgat tcgaggtcaa 3289081 agagaccccc taaagtccgc taaacgagaa gccatatttt cgagctctgc tctaatttct 3289141 gataattcca tttcattcac ctcattaaaa gatccgcagg cgcctgcagg cgccgcggtc 3289201 agtaaacttg ccggggcgaa ctattcagta cggccgcagc aatttttata ttttttcccg 3289261 cttccgcagt ggcatggggc atttcgtccg atatcaacca ctttgcgaac cggtgctttc 3289321 tttgcttttt tgttatcgtc gccttcttgc ggctgatgag ctgttgtttg accttgtaca 3289381 acctcttcac gctccagatt gttttcaatc tcagctttca tcacaaattt tgcgacttcg 3289441 tcctcaattg attcaatcat atgctcaaac atcgcaaaac cttccatttg atactcacga 3289501 agcgggttcg tctgcgcgta agcacgaagg tgaatccctt ggcggagctg atccatcgca 3289561 tcaatatgat ccatccattt agaatcaacg gcacgaagaa cgataacttt ttcgaattcg 3289621 cgcatttgct ctttgccgaa ttgctcttcc ttctcattat attttgtgat gatgcgatcc 3289681 ataatgagct caagcatttc atccggttct ttgccgaaga tatcgctctt ctcaagtgca 3289741 ccttcatcaa gataagttgt gttgataaga tcaactagac cgtcaagctt ccactcctca 3289801 ggaagctctt ctcttggcgt ataggctgca attgcgcgtt cgagagaaga cttgatcata 3289861 ttttcaacga tttcacgcag gttttcagag tcaatgactt caaagcgctg cttataaatg 3289921 acctcacgct gctggcggag aacatcatca tattgcagaa gctgtttacg cgaatcgaag 3289981 ttattgcctt cgacgcgttt ttgagacgat tcaaccgcgc gagataccat tttgctttgg 3290041 attggagtag agtcgtccat gccgaagcgg tcaagcatcg ccattgtccg ctcagctccg 3290101 aatctgcgca tcaattcatc ttccatagaa agataaaatt gagtaatccc cgggtctccc 3290161 tgacgtccgg aacgacctcg aagctgattg tcaatccggc gtgattcatg tcgttctgtt 3290221 ccgactacag cgagcccgcc aagctctttt acaccttcgc caagcttaat gtccgttccg 3290281 cgccccgcca tgttagtcgc aatcgtaact gcgccttttt ggccggcctc ttcaatgatc 3290341 tgcgcttcac gttcatggtt tttggcattt aacacttgat gcggaattcc tttgttttta 3290401 agcagcttag aaatcaattc agatgtttca acggcaaccg taccgactag aacaggctgt 3290461 cccgtcatgt aacgctgtgc gacatcctcc gcaactgcct taaactttcc ttccatcgtg 3290521 cggtaaatta aatccgggcg gtcatcacgg acaacaggcc tgttggtagg gatcgtgaca 3290581 acctgcatgt tgtagatgtt gcggaattct tcttcctctg tcttagctgt acccgtcata 3290641 ccggcaagtt tttcgtacat tcggaagtag ttttggaacg taatcgtcgc caaggtcatg 3290701 ctttcgtttt gaatctcaag cccttccttt gcttcaatcg cttggtgaag cccctcactg 3290761 tagcggcggc ctttcatcag acgtcccgtg aaggaatcaa caataacaac ctgtccgtct 3290821 tccactacat agtcaacgtc cttttgcatc gcaacgtgag cttttaaggc ctggttgata 3290881 tggtggttga gcgcgacatg cttcacatca aagaggttat cgatgccgaa tgctttttcc 3290941 gccttcgtca ttccttcttc agtaagctgt acagcttttg ttttgatatc gtacgtgtaa 3291001 tccttctccg cttttaacgt gcggacaaaa gcatttgcct gtacgtacag cttagtggat 3291061 tttgcagctt gtccagaaat gataagcggt gttcttgctt catcaattaa aatagagtca 3291121 acttcatcta ttaccgcaaa atgaagcggg cgctgaacca tctgctcttt ataaagaacc 3291181 atattgtcac gcaaatagtc gaagccaagc tcgttgtttg tggagtaagt aatatcagcg 3291241 gcataagctt cccgtttttc gtcttttgac attgagttta aattcaaacc gacagtcaaa 3291301 ccgagaaact cgaaaatttt ccccatttgc tcagcgtcac ggcttgccaa gtattcgttg 3291361 acagtcacga cgtgtacgcc tttaccggtt aacgcattta aataaacagg cagggtagac 3291421 gttaatgttt tcccttcccc tgttttcatt tccgctatat ttccgtcatg aagcgccacg 3291481 ccccccatga gctggacttt aaacggaaac atgcctgtta cgcggcgtga agcttctcga 3291541 acaacagcga aagcttcaac aagaagatca tccgttgtcg cccctttttc aagacgctct 3291601 ttaaattcaa ttgttttatg tttcaatgcg tcgtcagaga gattttcata gtctccgcga 3291661 atcgcatcaa tatcgttagc aattttttcg tatctattca gcgtacgttt tgttggatca 3291721 aacattttat ttaaaattcc aagcatttat aacgctcctc tatcatcaca cgcctatttt 3291781 agaggcatgt ataaataatt tactagtcca tgtatacctc tcattatcat atcatacctt 3291841 ttgttatttc caaagaattt gcaaataaga aaaacaaaaa ccttccgcgg acatcacgga 3291901 aggcttctct tcattattca gtcggttcaa ttaagccata tttcccgtca tttctgcggt 3291961 acacgacatt tgtaaggttt gtttccgcat ttgtgaaaac aaagaaatta tggccgagca 3292021 tattcatttg caagatcgct tcttcactat ccatcggctt taaattaaag cgtttctgac 3292081 ggacgatgtc caagctctcc tcctcttcta tgtcatcctg aaccgcaata tctgtatcag 3292141 agccaagacc gtttgccaat aaatattttg gagagccctg ctcacggaat ttacggttta 3292201 ctttcgtttt atgcttacgg atttgacgtt ccagtttgtt tgttgcgaga tcaattgcgt 3292261 tgtacatatc ctcgttatgc acctcggacc gaagcgccag atctgtcatc ggaatcgtaa 3292321 cctcaacctt agactccttg tcattgtaaa acttcaagtt gacgttcaca tcagcatcca 3292381 cgctatggtc aaaatagcgc tccagcttgc cgatcttcct ctcgacatga tcctttaacg 3292441 cgggtgtcac ttcaatattt tctcctctga tgttatagtt catcaaagaa cgcctccctt 3292501 ttattaagga tatgtatcta tttctctttt accctttaca attcctgctg aaacataaat 3292561 cttttgtgaa aattcagtga actttgtcga attttgtttg tatttgctct gttattggcg 3292621 gttcggaggt atatgtatat gctgattgaa cgaaacaaat acctcacaca cgcctaattg 3292681 attaaaaagg gttccataca ttgatgaata gacagcatcc attttctata atgaatcaga 3292741 aaatgttcct ttaaatactc acagaactca tgagagggaa aagagaaaga gaccaattga 3292801 tcaaactccg caaaaatttg gtcaaatgct ttcacacaaa tttcagcaca ccgcgaatcc 3292861 ataatgaaga gaagtgttga atgtgttgaa tccaaataaa aaaaggcttg gatcagatct 3292921 tggtagatcc gatccccttc tgtttttgat aaattctctt cagcctctat caaataacac 3292981 aacccctctt cgatggtaaa aagaagatga taataagctg ataaaagcgt ataatcttca 3293041 atgctcttca aggcactcac ctatttacgc ttgtcataat atgtgccgtc aatcgtaatg 3293101 ttgttataag ggtttaaata cgtcgtatgc atcacacgtt ttcttttcat ctgctgaagt 3293161 tctgttgcga ttgactgctt cagtctttcc atttccttca caatcagctg atcccatgtc 3293221 aaaataagtt tcatctgctt tcgctcttct tctgaaagcg gcagagatat ctcctgaatc 3293281 agttcagacc gtgtagccac aaagtcttca atttgcttta aaagttcatc gctttccggc 3293341 gtattttgta tgtgtgacag catactcttc gtctcagtgt atagttgatc tatattattc 3293401 atgcgatccc gcctgatccg tgccggtcct tccgctcact ttgaatggct tgtttccaag 3293461 catcgcgaaa atctgttaca taaccttcaa cctcagccag catgcccgta tcatttttga 3293521 tatttgcctg taccaatctg cgatacatat aatcgtacat cgcacccata gaagcggaaa 3293581 gctctatgtt acggttaagt gtaaaattta attcctgaat aatattttgc gctttaatca 3293641 gattttcatt tttacgttcc atatcatcat tctcaatggc ctgagcggca agtcttataa 3293701 atttcaaaca gccattatac agcataagcg tcagctcccc gggtgtagcc gtattcactg 3293761 aattttgctg ataggctgta tatggatttt ggatcgccat gtgtcatcct ccaaattaca 3293821 tttattgtac aagaagctgt gataaatagg acgcttgttc gttcattttt tgaatcgcag 3293881 aatccattgc actgaatttt gaataatagc ggttttctat ggtattcaat ctgtcctgca 3293941 tatcagttat ttcagtactt atcgagttta aattttttcc aatggaatag ctactagctc 3294001 ccattgtcga gttcccagct ttagcttcaa tacttttcac agtacttcta agtgtattag 3294061 taatccgctt cataatacct ttatcgctat agttactatc atttgttcca cttgtaaaaa 3294121 gattagcaac tccttgagga tcttctgcta tttttgcttt caatttctct tcgttaatct 3294181 ctaagtgccc tcgcagttgg taagcacttg aagttgtgat gccaaattca gttaattgat 3294241 aggttttccc atccgcattc acttgagtat aaaagtcagt ccgcatttgg ttcgtgccag 3294301 tgctgatgct tgaatcgttt ctcagcaatc cgcttttcgc cttctcctcc cagagctcta 3294361 cctctttatc ggacatggct tctttttgtt cactcgtgag tggcgtatag tctcggtatt 3294421 tttcttcttt cagcttttca ttcaggctgt caaccagttc attgtattta tctacaaact 3294481 ctttgatttg gttataaatc ccatcaacat cagtagaaac agatgtggta acagggcctg 3294541 tggctgcagt tgtattttta atcgaataag taacaccatt caccgtgaaa ttgtttgtca 3294601 gcttctccat ttcaaagccg ttgattgtga ctttggcatt tgtgccttct ttgtaagcag 3294661 taagcttatt atcagcatcc aaagaaaaac caagctgacc ggacataaag tcagctgtag 3294721 cagagtctgc tgcctgtatg cttcctcctg cacctgttgc tttagaagaa aacgcaatcg 3294781 tttctacgta ctctgtacca ttccaaattt tatctttaaa tgctgatact cctagatctg 3294841 agctgttaag tttagaaatc acattatcaa tcgtatcggc actcgtcaca ctaatgttca 3294901 ctgtttttgc tgttgtttcg ccaggcgcaa caacgttaaa tgccaaattg taatcgcctt 3294961 gtgtgtatcc cgtataattg tttgccttat acgttgctgc agttgccaag ctcgccactt 3295021 caacagtaga cgaagaattt ggcgcactta cgcttcctgt agcagttaac acagactcat 3295081 tagagcttgt cacagttttg ctctgatacg tgctcggata tgtcaacgta tttttagaca 3295141 tataatcttg caattctttt atttttgagt ttacttcacg atagctgtca cgctgccatt 3295201 caagagtctg ctttttttgt gtcagcttat caagcggcgc tctttctgtc tgcatcagct 3295261 ttgatacgat atcatctata tccattcctg acgccagacc tgttattctt gtgaccatct 3295321 caaaccactc ctattctact ttttttcatc tacaaataac ccaagaaatt cagtcatagc 3295381 cgcataaaaa tcaagccacc gttttggtgg aatttcgcgg atcacttcat ttgtagagtc 3295441 ctctattacc tttacatagt attcatttaa cttgtcatga agctcgaact tcagatgaac 3295501 ttgcgaaggt tccaaaagct tgttcatttc ccccaccatt tcagcaagat tggtatatga 3295561 aacttgatga acaggaacct cgttatcatt atctttctga ttatgtattt gagtatcata 3295621 acgatcccaa acaggttgta acgtagtgag cctttcaatg ttcaattgat catcccctat 3295681 gccccaatct atcgtttata tcgactaagt cgagataaga ttacacatat ttttggaaaa 3295741 aaatcttctg ttttagattt cttgtatgga aatacattta taaaaagtta gtggagaatc 3295801 cggttattat atcatgagtt agtgacagga tgaggaatga ttaggagata gaaatttaaa 3295861 ttaaaagacc ctggcaacgc caaggtcttt tttaaaatta acgtaataat tgaagtacgt 3295921 tttgcggctg ttggtttgct tgagcaagca tagcttgaga agcctgagaa agaatgttgt 3295981 tctttgtgaa ttcgctcatc tctttagcca tgtcaacgtc acggatacga gactcagcag 3296041 ctgtcaagtt ttcaccagaa gcgcttaagt tgttaattgt gtgctctaga cgattttgta 3296101 ccgcaccaag cttagcacgt tgagaagaaa cttggttgat cgcttcatca acaactttca 3296161 attgagcatc gaaaccgata tcagcagtat ctgctgcatt atctgcgaat tttgttacgt 3296221 caagatcatt aactgaatga agagctgcaa ttgaaccatc agcttcttta attccaagag 3296281 cgtcagcacc catatcctca atatttacag agatttgctg tgtagcattt gctccgattt 3296341 ggaataccaa gttcttttga tttgcaggag tagctgtgtc aactttgtaa gtgccatcga 3296401 gcaatttctt accattgaat tctgtacgat ttgaaatacc atcgatttca tctgttaaag 3296461 ctgaaatttc atcttgaata gattgcaaat cagttgcttt gtcctgagtt ccagtgtttc 3296521 cagcttgaac aactagctca cgaacacgtt gaaggatcgc atgagtttca gttaatgcac 3296581 cctcagctgt ttggataaga gagattccgt cttgagagtt tttagaagcc atttcaagac 3296641 ctctgatttg tcctctcatt ttttcagaga tcgcaagacc tgctgcgtca tctcccgcac 3296701 ggttgatgcg aagacctgaa gaaagtttct ccatgttctt ttggctcgca ctgttgtttg 3296761 aagacaaacg gttcagtgtg ttaagcgctg caatattgtg gttaattctc attgttttgt 3296821 tcctccctga atatgttgtt aaggcacgtc cttgtgccct tattttgtaa ctggctgagt 3296881 cttttgcgcc tcctcccggc tacatcatta atatcggatt gtctctgatt ttgttaatac 3296941 aaaaataaaa aaatcctcac tttttttgtg aggataatgc ggagatcaca tcgctggata 3297001 acgctgctgc acggttattt tcttcctgaa tggtcaagta aatttctttc ctgtgaatat 3297061 caatatgctt tggggcgtca attccaagct tcacttgatc cccttcaacc gcaatcactt 3297121 ttacttcaat atcagcacct atttgaatcg cttcgtttat tttccgcgat aaaactagca 3297181 tgattctcct ccaatcggat gctttgtcgt atatgaggag tcgtgtaaaa cgacttgctt 3297241 agccatcatg ttcttgcgat tcacaataat gggagccaat aaattcgcag tagacttttc 3297301 aaatggctct gccatagtca atattgtcat gacttctacg tcttgaatat tatcgatatc 3297361 caaaagttca gcagttgatt catcaagatc aaattcataa ttcttaaaaa agataaacgg 3297421 acttacgacg ataaacgcaa gattttctga agtgacggac tgcagtgcca cgaatggaga 3297481 gtcttctgaa agcggaagta tgacgaactg tttttcttct aaaaagcctg gaatcccgct 3297541 ttcaaaaaga atgatttgtt cttcttttat gttcatttgg ccatggtact tcgtatgaat 3297601 gatcattgtt cacgatcctt ttctttttac ttttcgggtg attctttcgg gtattctaca 3297661 tctatattta aatcagggta ttgaagcatg tcaaccttaa catttcctgg cgtatattca 3297721 acaattggct tatgcggctc agcctgaata acaggctttc gcggcgtaat ctgcacatca 3297781 agctgtgacg gagtatattg tattttcacc ctcgaaagag aaggagcata attttcgcct 3297841 aattgaattt ggtgcatttc agagttcctc cttgcttgtg aagcgattgg gttcccctta 3297901 ttttcaatct tcataagctc gtcgccttct tctgcagtgc gtgctattcc ctccattaca 3297961 tcctcatgcc cttgttgggc ggcttcttca attctcttga aaacatgctt tctgtctaat 3298021 tcttcccatg cttgtgtctg gtcaatcgtg agttttccag gtgtcaccga tatttccatt 3298081 tccgcactcg gctgttcgat ctctagatca gcttgaggct gctccatttt taagctggca 3298141 ggcgtcgttg ttaaaccaat ttttccttga acactatgca taatcaatct gggaatctgc 3298201 atcactctac ctcctgaact ataaaaaaag cgaactccta agagccgctt actttaaaaa 3298261 gtcaatcaat gtaggctgaa caatttgcgc attaacggcc agagtagccc tgtgcacact 3298321 ttgctgcgca ataaattcag ttattacttc ttccagttct acatcttcat tgtctgataa 3298381 cactttggta gctgtttctt cttgcgctga cagtcttgta ttaaccagtt caagacgatt 3298441 atatctcgct ccaagatcag atcgttcagc gctcatgccg tcagaaaaat gatcaatatc 3298501 atttaaaaca ctgtccatgc catctagcga accagaattt agtgctttct caaaagaatc 3298561 aagcatttca aatacattct gcccgctttc agaagtgcct ccaaaagctg actttggatc 3298621 tgaattcact ttcaatgaca tattatttga tatattgact acgacatcag ctgtatcaga 3298681 aattgtataa gttccgtctc cgttatctgt aaccggaggc ttatctgaat ttgtgccatt 3298741 aaagatatat ctgccgttca cttgtgtatt cgcaatattt aaaagctgtt cctttaactg 3298801 ctttacctct acgccaatcg cttgccgctc cggctcgccg tttgtatcat tttgagcttc 3298861 aaccgctaat tctctgacct ttgacaagat gtcaattcct tctgtaatgt ttgtttctgt 3298921 gttttcgagc caggtaaagg cttgagaagc attgcttttg tactgctgca cttgagacag 3298981 ttgcgtatta tactttaagc ttttcattgc tactacagga tcgtcggaag cttttgagat 3299041 tttttttcct gaagaaatct gcgactggag tttatccagc ttcgagtagc ttgaaccgat 3299101 atatctcagt gagttttgct gtatcatgcc ttgtgttact ctcatgtgac tctacctacc 3299161 ttcctccaac acccatgccg ttgatcactt tatcaagcaa ttcgtcttgt aaagtcacca 3299221 ttcttgcagc tgcattgtat gcgtgttgga attgaatcat attcgtcatt tcttcgtcta 3299281 aagaaactgc gctcatttgc tgacggttta tgtcagcatc attcagctgt gtttctgtat 3299341 tagacgccag tcgattagcc tcttgagctt cgatccctag ctcgccaatc agacccgcat 3299401 aataatctaa aacactagtt tctttaccgt taatggttat tttaccggtt aaaacatttg 3299461 ctaattttgt agcatttgcg ttatcgttgg ctgcgccagt cagtgagaaa gcaatgtttg 3299521 cgccttttga atctattatg ctgtcagcca ctttgatctt gcccgccgcg cccttggcag 3299581 gttcagtttc accgccagta aaatcaaaaa agtctccgcc ttgttcaccg ctcttggtca 3299641 caccatttct gtgcacttca ttgaaagctt tcgcgaattc aagcgccata ttgtcaagat 3299701 cagaaagcat ttccgggtat acgccctttt cttggccatc tgctgttata tacccataag 3299761 actctataaa ccctaaaagg gatcccttgc tgctaaagga ctccgcctgt acagctgtat 3299821 ccccgattga aatacttgat actaacccag tttcattatc atagttggct gcaagttctg 3299881 aaacctcgta atttttaccg tccaaaacag ttcctagcga ctgtttattt ttatcaagga 3299941 tttcaattga tacagttcct tcagcagatg caagtgcatt cccgcctgat ttgttgtagc 3300001 tgactttgat atcaaccatt gaggataatt tatcgatcag caaatctcgc tggtcatata 3300061 agccattcgg aagaagcccg accggctcta cttgtgcaat ttgcttattt aaactgttta 3300121 actgagaaag cagagaattg acatccaaca cagttgtatt tagctctgct tttaaattcg 3300181 attggacatt tgtaagtgat tcagaaatat aattaaacgt ttcagctaca gcttgtcctt 3300241 ttcgagcaac aacagaacgt gcactttctt catttgtatt attcgataat tcctgcaggg 3300301 aattccaaaa cgaattgagc acactgttca agccgctgtc atccgtttca tttaaaacgc 3300361 cttccatttg ggacagcgct tttgccttcg tgtcatagta tccggcactg ttgttttgaa 3300421 gacggtattg gtagtcaaga aagatatctc ttattctctc aactgatttt ccttgaacgc 3300481 ccgtacccat ttgtcccgct gttttttctg catttttaga tacagcaggg aaatagtcag 3300541 ttgcctccaa tgagacccgc tgtcttgtat aaccatcagt attggcattt gccacgttat 3300601 ttgcagtagt gcttaacgct gcctgctgag cgcttaacgc ccgccttgca gtttcaagcc 3300661 ccataaaggt agatgtcatt ttctgaattc ctttctgcta agcttttgaa tcaaacagtt 3300721 tcattttgct acttttcggc agctcagctt taattgattt gctgtaattg aagttatttt 3300781 ccttaggaac cagcatatcg tacgaaatag agatgaattg cagcgcgtct cttgtcagct 3300841 gcctattcat ctcatttact tttttcagac gtccgagaac ttgagaaaga gattcgtata 3300901 gttgttccag ctcttccttt tcactgcctg aggttttggc gatacatgcg gaaatagtat 3300961 tattttcgct atatccgaga aaggccgaag ttgttttgat ccggtcatct tctgtctgcg 3301021 tgattgcttg aatatatttt tgctcttttg tcaaaatgtt agaaagctct tttgttttgc 3301081 cggctttgag cgcttccgtc ttttcttcag acagcgtgag caggtgctca tgcagaacgc 3301141 aaagtcgctt caattgttca ataattgcct tcgctgacat gggctttctc cttttttatt 3301201 gctttttata aaaattaatc atatttttcg caatatgatt tgcgtctact ttgtatgacc 3301261 cgttttcaat ttgcgcttta agctgcgcaa ttttttcctg tcgtgaacca gtgactgcgt 3301321 cggatgcatg ttgcatttct ttagcctgtg atgaaatttc aattttatct tgaggttgtg 3301381 caacagtttt ttgcaccgct tgcttatcat aatttttttg atatggatta acggattgtg 3301441 ttccaaattg attgattttc ataggattcc tctcgctttc cgttgcagtc tttaaacaat 3301501 cttaaccctt ttatcgactg cgttttcagt tagtttaggg aatcagctgt ttttggtatt 3301561 ataggcatag tatgtgtctt ttttactatt ttctttctcg attttcagag catcctcgtg 3301621 gttcaaatga tccatttgat ccttaatatc agactggcaa gccttgcaga acttgccttc 3301681 tctaatcgat gtcccgcacc tttcacaagg gtatgccaaa ttaggaagat gagtgatctg 3301741 aattcgcttc tgcctgatga atttcaatat cagctcttct tccacacctg tttcctcagt 3301801 tatccggctc aaagttgatt gccggttttc ctgttttctt aaaaatttat agacagtctc 3301861 aaatgatttt tcttcttcct taatacacgc ctgacatacg gtttgcagct ttgtttttaa 3301921 aaataaagca ttgcatttcg gacaattagc cagttctccc atcttttttt ctccttatta 3301981 gataatatgc ctgtgtcaat ttctagtgat tatatcggca taaaaacaga atcatttagc 3302041 ttctgatcaa ggtaaaagat gacactgaag cggcttttcc tttttctaat aagcagcggg 3302101 ctgcgaagtg caaggtggcg cctgttgtat aaagatcgtc tattaaaatg atattcatac 3302161 cttctgctga attatttttt gtatcaaaaa tgcactctga cagcaggcgt tctgttttct 3302221 ttttctttga ctgtttctca ttattcaggc gaatgagggg atggtgggaa ggccggtcta 3302281 aacattctgc caagagatgt gcctggttaa atccgcgctc ttcttcccgt tccttgctca 3302341 gcggaatagg tacaagaaca aaatgcttat cggggtaaac cttagaaaag gttgaagaaa 3302401 aatcactttt aaatgcattt atgatttctg catctcctct aaatttaaaa cgggagagcg 3302461 tttctttcat catatcatta tatgtgtaaa ctgaacggtt ttgacgcaat agcaaactgt 3302521 ctctgatcct tgttctccac acctcgcaat ccctgcatac ggcatgaaca gattgaggtc 3302581 tgccgcacag ggggcagata tgtcctgtga ttttctttaa tttgcttctg caagaataac 3302641 aaaccttttc atcaggcttt agtaaaaaaa gggctctcca tgtaacatct tgagaaaatt 3302701 gcgaatcaca taataaacag atcagtttat gaatgcctcc tcctgcttcg tttgacataa 3302761 atcgcttgga ctctctgaaa ctactgcagc agattcagcc aaaatgacaa gcattgctgt 3302821 gtttttttgt ttatctacca gctcagcttt cgtatatgcg atctttttaa aatcagtaac 3302881 gtaggatgga ctcactttgt ttaaagaaag tgccaataca tcgttttggc atacttggca 3302941 agtacaggcc atatgaagct ggtccatata tcggtcgagc agttctttca ttacgatttc 3303001 ttttgaattg acaagcattt ttacagctcc tcatcatcgg ttatatgagt atactgtacc 3303061 acgttttcaa ataatggcta gtctgtacat tcaacttttg ctgccaattc attcatttct 3303121 tttatatgct ttcttgcatc gagcatactc tttgttttgc cgaagtgaaa gtaaatgaca 3303181 tcgccgtccg catattcttt atgccggccg gttcttcctg caatttgaac aagtgcgctt 3303241 tccgtaaaga tagacgattc cgctcctagt acacccgttt gcaccttggg gactgtgacg 3303301 cctctttcca gtattgttgt tgtgattaat agatcgagct gaccatctct gaattgctgc 3303361 actttctcct ttctatgctt gtcttccgcg tgcacagatg cggttcggca atgaacacct 3303421 ttaaagcacg cagcagcctt ttccagaata gaaacggaag gaacgaataa aaaaacaggc 3303481 ctcccttctt ttacatgaaa ctctatccat cttttcaccg ctggcggaat tttatttcgg 3303541 tttaatttct tcttccagtt tccacaccat acaaagcgcg gttcgggtaa aggtttccgg 3303601 tggtgtcttg cggggatgcg aactgaatgt aactgtccgt tcagtgcttt tctttttaat 3303661 tctttaggag gtgttgcact taaataaacg agggtgctgt ttttctttct tgctttttga 3303721 acagcgaatt gaagggtttg atcagcagaa tatggaaaag cgtcaacttc atcaatgatc 3303781 ataacatcga ttgcatcttt atatcgcaaa agctgatgcg tagtggaaat cataagcgga 3303841 gatagccgcc ctttgtcatc gcttcctccg taaagcgctg aaatgtcagc accctgaaag 3303901 gcagccttga gtcttggagc aagctctaat acaacatcgg tgcgaggtgt tgcaatacat 3303961 acacgcagtc cttgatttaa cgctgattct ataccaggaa acagcatttc tgttttgcca 3304021 gcgccgcaaa ccgcccagat gaggagctct tctttttttg atattgcttc aattaaaaca 3304081 ttggcggctt tttgctgtcc gcttgaaagc ttgccatccc atgtcagctt aatagacttc 3304141 cagtttgatt cattttcctc tttccatgaa tataaaggaa cctcctcact cactctgccc 3304201 atcatgacac aggaacggca atacagctta ttctttccag atgagtgata aaaagaaaaa 3304261 taccgctgat cagtttgtcc gcacctatta catctatatc tccgtttatt tatggatata 3304321 gaattttcag cagtgatata tccattcttg atatgccatt caatcatctc atcggaaaat 3304381 gagagctcag tcctgagcaa atgacggctt cgaagcgtct gctgcaattc ttttgaaaag 3304441 gaactgtttt tttcaactgg cacattcaca tagcacgcct cctttcgaaa cagtatgcct 3304501 gaatgaatat tttctgtcca actattaaaa taagaatata aaaaaatctc cgctctaaaa 3304561 acggagattt ggccttattt aaaacaccag caaattccta acgcaccttc acccaaatga 3304621 gtgccgatta ccgcgccaaa atagctgtta taaaattcaa catgaggata ttttgcagaa 3304681 agctcttcaa tgattttcgc tgcttcttcc tctcgattag cgtggataac agcagctcgc 3304741 ataggcaacc ctttactcgc atcttcgtct aaaagctcat aaattcgcga aattgctttt 3304801 ttacgtgtgc gaatcttctc aaaaggcaca attaccttat tgtcaaaatg aaggataggc 3304861 tttaccttta gaagactacc aatgaaggct tgggcgctgc ttaatcgccc gccgcgctga 3304921 agatgggcta agtcatctac cataaaataa gctcgaactg tttttttcat ttcttccagt 3304981 tcttttataa tatcttccgg cgatgatgct ccgtttttga ttaattcagc agctttaagg 3305041 gcataaaagc cttgagccaa gcagctgatc tctgagtcaa atggatacac atcaatattg 3305101 tcgaccatcg aatcagccgc tgctgcactg ctgaatgttc cgctgatccc gctggaaaga 3305161 tggatactga taaccgcatc ataagacttg ccaagctctt catacaacgc aaccagctcg 3305221 ccgattggcg gctgagaagt cgtcgggagc tcattatgtt ttttcacttc ttcataaaag 3305281 cttttccagt ccaactcaat ttcttcacgg taagtctcct ccctaaaaac aacctggaga 3305341 gggatcatat gtatctgatg ttgttcacgc atttctttcg gaatatatgc cgtgctgtct 3305401 gttacgactg caatattcat agcttcgata cctgccttat tgctttataa ctctattgta 3305461 agggaaacgg cagcctaaaa aaagacctgc ctagtaaaag gcaagtctcc tattatacta 3305521 tctcatttct acccagccat ttttaatggc gaccacaacg gcttgcgtcc ggtcgtttac 3305581 attcattttt tgtaaaatat tgctgacatg gtttttaacg gttttctcac tgataaacaa 3305641 tgattcacca ataccgcggt tgctttttcc gtctgcaagc atctgcagca cttcacattc 3305701 ccgcctagtt aaaatatgta atggtctgcg gatttcaggg taaacctcat gttgagggtg 3305761 tgcagaaact ccgcttgttg caaggcggcg gaattcgtta acgaggttgt gagtaacctt 3305821 cggatggagg taagatccgc cctcagccac tactttaacc gcttcaatta atgtatcagc 3305881 atccatctct ttcagcagat aacctcttgc acctgttttc agggcatgtg ttacataatt 3305941 ttcgtcatcg tgaattgata gaataattac tttagattca ggatacagct ctacaagctg 3306001 ttttgtagct tccacaccat ttacgtttgg catattgata tccatgatca caacatcagg 3306061 atgatagtgc tcaacaatac gagccgcttc gtccccgtca tcaccttcgg ctaccacttc 3306121 aaaggtaggt tcaaaatcca atatccgttt aacaccttca cgaaataact gatggtcgtc 3306181 gataataaca atgtttactt tagtcacaag ccacgcctcc ttgtattatt gttctatata 3306241 ctctagcatt cggtcaatat gccttttggc tctattttac aaatcatagt caaagagata 3306301 acggaacctt aatcataata aatgtcccaa gacctatttt cgaatctatt gtcatcgttc 3306361 cttccaataa atctactctt tctttcatgc ccagcaagcc gaatgatttg tttttcttct 3306421 ctttcgcttc cttcaggtcg aaccctttac cgttatcttt tatcattaaa atcacaaaat 3306481 cctttgtgat ctcaactttg actgtaattt cttcagattc agaatgcttt agcgcattag 3306541 acacagcttc ctgtgcgagc ctgaagagcg caacctcaaa ctgaggcgct agcctctgat 3306601 cctctgtttc tccaatgcac tgaaaatgta ttttgacctt cccgttatat tcctcggttg 3306661 tatatagata ttttcttaaa gttggaatca ggcctaggtc atcaagggcc atcggtctta 3306721 aatcatatat aatccttctc acttcgtaaa gggcattccg aacattttgg cggagatttt 3306781 taatttcttg gaatccgtcc tctgcgcccc ggtcacggaa aatccgctcg attaattccg 3306841 atctcatcat aacattcgcc agcatttgag cgggtccgtc atggatttct cttgagactc 3306901 tttttcgctc ttcttcctgc gcctcaataa ttcttaagcc gaaatcctgt tttgcctgag 3306961 catcagcaag aagcagtcca acttcgcgca aatcctgatt caagtagttg agcacaactg 3307021 taatttggct tactaatgat tctgaccgct caatgatttc ctgaagccct agcaatctgc 3307081 gctccaaatc gtcccgccgt tcgcgcaatt gcttctcacg ctgctggatc atcgtcaatt 3307141 ctacctgcag cttatgggct ttttcataag cattgcggat ttcctcttca ctgaatctat 3307201 gaaaattacg gctgacctcg gataaacggt ttctcgcatg gcgagtttgc acttcaagtt 3307261 tatcgccaag ctcaatcact tcatacacct gctgtttaat ttgtttcagt tcttcgacca 3307321 gctgttcata ctgctggcgt gactgctccc cgatttgaaa aacctcgtcc ttgctcccgt 3307381 caacggtttt cagcatcttc atcaaaatag aatccagcac tttggaatcc atctttgttt 3307441 tattcataat ttccctccgt cacggcgttg tcatatattt ttattataaa tgtaattgat 3307501 ctgcaaatta tgtcgaatta taatgaaaga atgcgtatat tctagaaaaa aacattttta 3307561 tatactatct actctttatg ataccaaaat acgcacaaaa attctaaaga ctgtacgaat 3307621 ttgtataggc agtcttttat gcttagcagg agggtcagct agcatgctgc acagctattt 3307681 tactgtgaaa gaagcgggag aacacgagat tgttatagaa aaatcgcgtt ttatctgtca 3307741 tttaagccgt gtttctaccg aacaagaggc acaggaattt atacagaaaa taaagaaaca 3307801 gcactggaat gcgactcata attgctcggc ttatgttatt ggcgagaatg atcatatcca 3307861 aaaagccaat gatgacgggg aaccaagcgg tacagcggga gtgccgatgc tcgaggtttt 3307921 aaaaaaacgc aggctgaagg atacttgcgc cgtcgttaca cgctacttcg gaggcattaa 3307981 gcttggtgct ggcggattaa ttcgcgctta tgggaaatca gtgtctgaag gattaaatca 3308041 tataggtgtt gtagaacgga agcttatgcg aatcatgcat acttctgcag attacacatg 3308101 gcttggcaag attgaaaatg aattaaggga gtcacaattt ctgttaaagg aaatccatta 3308161 ttcagaaaat gttgaattcg aaacatacgt ggaagaaaaa gaaaccaacg ctttttctga 3308221 atggatgaca gaactgacaa atggaaagag tgatattaaa gagggagagt tgacgtatct 3308281 tgaaaaagcc gtcaatcaca taaaggagac tgaataatgg ctgaacgcgt tagagtgcgt 3308341 gtgcgaaaaa agaaaaagag caaacgtagg aaaattttaa aaagaataat gttattgttc 3308401 gcccttgcac tattggtagt tgtagggctt ggcgggtata aactttataa aaccattaac 3308461 gctgcggatg aatcgtacga tgccctatcc cgcgggaata aatcaaatct tcgcaacgaa 3308521 gttgtagaca tgaagaaaaa accattttct attttattta tgggaataga ggattacgcg 3308581 actaaaggac aaaaagggag atcagactct cttattgttg ttaccctgga tcccaaaaat 3308641 aaaaccatga aaatgctgag cattccgcgt gacacacgtg tgcaattagc tggtgacaca 3308701 acgggaagca agacgaagat caatgccgct tacagcaaag gcggtaaaga tgaaacagtt 3308761 gaaactgttg aaaacttctt gcaaatcccg atcgataaat atgtcacagt tgattttgac 3308821 ggatttaaag atgtgattaa tgaagtcggc ggtattgatg ttgacgtgcc tttcgatttc 3308881 gatgaaaaaa gtgatgtaga cgaaagcaaa cggatttact tcaaaaaagg cgagatgcat 3308941 ttgaacggcg aagaagcctt agcatatgcc cggatgagaa aacaggataa acgcggagac 3309001 tttggccgta atgacagaca aaaacaaatc ttaaacgcgc tgattgaccg catgtcaagt 3309061 gcaagcaaca ttgctaaaat tgataaaatc gcagaaaaag ccagcgaaaa cgttgaaacc 3309121 aatattcgca ttactgaagg tttagcgctt cagcagattt acagcggctt taccagcaaa 3309181 aaaatcgaca cattgagcat tacaggttct gatttgtatt tagggcctaa caacacatat 3309241 tactttgaac ctgatgctac aaatctcgag aaagtcagaa aaacgcttca agagcattta 3309301 gattatactc ctgatacaag cactggcact tccggtaccg aagacgggac tgacagctca 3309361 agcagttctg gcagcactgg cagcactggc acaacaactg acgggacgac gaacggaagc 3309421 agctattcga atgacagcag cacaagctca aacaacagta caacgaattc aacaactgat 3309481 tcatcctatt aaaaaatgcc cggtcctttt agaggatcgg gcatttttgc gcagaaaaaa 3309541 actccggcac ataagccgga gtttttaatt ccttttcacc agccgtttat aaaactttgt 3309601 aaacggctta aatttttcat tcacgagtcc tgtcacttct gctatgattt gcataaaaat 3309661 aatcaaaatg aagataataa acaaagaaag ccaaattgtg gcacttttaa gtacaatcgc 3309721 actgatactg aaaataaatc caattaaata aataactaag accgacatcc gatgtgaaag 3309781 gccaaaggcc atcagtctat ggtgaatatg cgacttatca ggcgctgaaa tcggctgttt 3309841 gtttaatatt cttctgatga tagcaaatgt tgtatcaaaa atcggtacgc ctaatataat 3309901 aatcgggata acgatactga acaatgtgac acttttatac aggcctaata atgaaagaat 3309961 cgagatacta taccctaaaa acagtgatcc cgtatctccc ataaagattt ttgccggatg 3310021 gaagttgtaa aacaaaaacc ccagcgtgct ggcaataacg actaatgaga gtgacagaat 3310081 gagcactttt ccgccggata gcgccatgac agcaatcgtt gacaggccga taacagaaag 3310141 accggcagca aggccatcca atccatcaat caggttaatt gcgttcgtga tgccgacaat 3310201 ccataatacc gtcagcggat aagccatcca tcctaactca aatcgttctg ttaaaaaagg 3310261 tactgagaaa aagtccattt ttaagccagt gcttacaatc ataatggcta cacctaattg 3310321 aatcaaaaac ttaacttttg cacttaattg atatttatcg tcaagaatac ctaacacaat 3310381 aatgatgaat gctccgactg taattgccgt catccttgtt tctgtgtaaa taccggatgc 3310441 aagcacgcct gcaaccaccc cgataaatat ggccagcccg cccatgcggg gcatgatttt 3310501 gtcatgtact tttcgattgc tgggctggtc aactgcacct attttaatcg caatcctttt 3310561 tacgattggg gttatgatta aaactgtcag cagcgagaca ataaacgcaa caacaatgcg 3310621 aatcatgcgt tcgtcaagca taaagaagtc tcctttggaa ttaaatgaag tctttattta 3310681 tatagagaac cgttccttcc attatacctt ctccttagtt attataacaa gcttcatcaa 3310741 aaagaaacac gtataatcaa aaaacgcgca tcccaattta taggactacg catgtttttg 3310801 aatccctgta tatttcataa tttgtctaaa taagcaattc caatcttgtg tccgggcgat 3310861 gtttcggcgc atttctttat aggtctcgtc tccgttttga ccgagaactt tttcacaagc 3310921 ggctataaaa tcaatcggat gatcgccctc tacatattcg tatacatacg gcttttgcat 3310981 ttttgaggtt gacggaagat tagtgcctac aacaggtttt cctgccgcta aaaattcaaa 3311041 tagtttcagc ggaaacacag cttgattata cggtgattgt ttatatggca taatgccaat 3311101 gtcgataagc tccatataat gaggcacttc ttttggatct gccggaccgg tccatatgac 3311161 attgggaagc ctcagcagct cttgaaacga aacatcacca ttggtggcat ccgggccaac 3311221 ccataaaaat gtccaatcag gcttttgcag tgccgcttct ttaatcattt taaaatcgag 3311281 cttcggttta atcccgccaa taaaacctaa cactattcct tctctcccct gcagtatact 3311341 gcgatcggga gcttgtttat ttgcagaaaa cagctcatac tccacaccgt tttccacagt 3311401 atgaaccttt tctcgtcctg cagtcagttt tttgtctact tccttgtgaa gataatctga 3311461 tgaacaggtt attgaatctg ctcgttgtat aattctcagc tctgccgatt taatgacttt 3311521 tcgccggaat tcagacagca gatttgatcg gccgctgatc ggcgcagccc ataggtcact 3311581 gcagtcataa atgacctgat cccaagaata cagcgaagac agcagcggga atccgggaaa 3311641 cgtgtaccat aaacagcagc gttcaccgtt tgcagaagca ggtgtaagct catcgagtaa 3311701 tggggagagc ttatgtctgt aaaagacatc tgtatatcgt ccgaaacgaa acattttttt 3311761 ctgcagcagg tctttgacag cgaattgcct gatgccagaa tggacttcct gaaactcttt 3311821 cccttgggca cgcggagccg gacataccca aataacttcc ttcgtttcct cctgagcagc 3311881 taaaaattct gccagccggt gccttctgta tctcaattgg tcttttcccc attcagcagt 3311941 ggcaacgatg acatgaatga ttgcttcttt tgtttccacc ttcatcacct tttctctctg 3312001 tttgcagcta taatcttttt ttcaccgcgt tttttgcata ttgaacaaaa caccatgttg 3312061 ctttcataaa atgaagccgt tcgatctccc tgtagacaaa ccacgttttt ttcgcagcct 3312121 tccatttgtt gctggaaatt gaattattga caagccgata ttcagccagg cattcattca 3312181 ttccataggc agtaaatcct ttttttaaaa gagacagcca tgtggctaag tcctgtctcg 3312241 ttctgatatt cggcatttgg atctgtcccg tttgctccct gtcaatcatc accgtcaagc 3312301 agccgataat tgtatttttc agggcgtcat cgtacgtcag gctttccggc gcatgaataa 3312361 atttatcgag cggggtcccg tcctgcgcca ttaagctgta gcccgtgaaa gagaacgcac 3312421 aggagcgctc catcataaac tcaagctgct tttccagttt gtcttttttc catttgtcat 3312481 cactgtccaa aaatgctacg tagcgccctt gagcgcgttc caacgctttg ttgcgagcaa 3312541 ccgcagctcc ggagttctct tccagataca ccacatgaat tctttcgtct attttttcat 3312601 actgctgtaa aatgtcgcgg gtcccatccg ttgagcaatc atccacgata atcatttccc 3312661 aatgaggatg gctctgatct aataccgaat gaaccgtgtc ttcaatatag tcacgcgcat 3312721 tataggaagg tgtaatgaca gatacgagag gtttccaatt ggtcatgatc acatctccat 3312781 cgtatgattt taaaaggatt ctctgaaaaa ttcaggaatg acaacgaaca taaaggcaat 3312841 cgtaaggcca atcataacgc cgagaactgc tttctttttc ggagacatac cgccgcctgc 3312901 tgtctcactt acggtttcgg aatcagtaac acttgccgct ttcaggttaa gctgtgtgtt 3312961 tttgagttca tataaaaatc tctctttatc cactttggaa tcctcgctca ccgactcgcc 3313021 ttcaagcgcg tctatgctgc tgcggatgac ggcttctctt tctgcataca gcttttgatc 3313081 gtttttgagg aaggtggagg atatggcgtt taagacagat tccgttctat ccttatcctc 3313141 gtcactatag cttaaagtca gtaacgattt ggattccgta ttgattgtaa gcttctcttt 3313201 gatctctgct acatcttcat ccttttcatc aggaagcgcc tccttcaaaa aggagtcgct 3313261 ctttaataga agcggaatct cttctgtgct gttataaacc ggatgatcat agctccccac 3313321 agccaaagta tcttcagctg tatagctctt ttgatcagcg atctgtgacg gcaggatata 3313381 ccccgccgca cctaatataa ttggcaccgc tatgatccaa atgatatttt tttttatgcg 3313441 acgggctatt cttatcaata tatcgttcat ataagtctcc ctgctttttg tagtctgttt 3313501 atctgtacat cggctcaggc atttgtctgg atcgccttaa cacattcacg gcggcgatga 3313561 cgagcgccat aaacacccaa tggaaaaata aatttgaaac agagcttggg ctgatacttg 3313621 ataccaggaa actgaccata gcggtaataa gtccttctgt gatcagtttt gactgatttt 3313681 ctaattttct ttcataaaac ttgtaaagca cccatatgag gtaggcataa acggacaaat 3313741 atcccagcat gatgaacaaa ccaaaattag caagaatttc aacaagccag ttatgcacct 3313801 ctgccacatt gtcagtatca tatacagcat aatgctcaag ataataggat acatttcctg 3313861 ccccgactcc gaatccgtat gaatcaagga aaaaatgcca agcgtttttc agcagatttg 3313921 cccgagccac atttgatgga agcctgtcat gaaatgaatg cagcgtctgc ggggccagaa 3313981 acagctccca aaactttgaa tagattttgc tggcgaaaag aactgcgaaa agagcaattc 3314041 ccgccgccga cagccatata gccattctct ttaaaacagg cggcaataca atgaagatgt 3314101 agacagcaat acctgcaaaa atgcccagaa ggctggctct tgaaccagtg gcaaaaatta 3314161 aatacaacgc acagagcgag agcacaaggc caattgcctt gatgtatcca ttcttaatgt 3314221 ttttcatcat cgtgatgtaa aaaaagaagc tgatggataa aaaggtcgca aagtcatttt 3314281 gattaaaaaa gaccgatgtc ggataatgct gcttgtactc cggtccgctg tacaatgtgg 3314341 aactcgcaag atgatggtgg gtgatatgat tgtaaaaacc aatgatcatc agaaataccg 3314401 tcatcaccag ccaaatggca taaacaatca tcagccgctc cattttttgc acgtacatga 3314461 caataagata aatgaagaag atccccattg ccaataaggc taaatacttg aggccaactg 3314521 ttaccgactt ggcccacagc agagaaacaa ggccatatat aaaccaaaag gcgaaaaaga 3314581 gtaaaatccc ttttacttgc agcccatgcc atctttcaat atgggttcga ttccgaacca 3314641 tgccgaaaat atgaaggcaa cccgctgcaa tgagcagaag ccggtaaagg aacaaactga 3314701 aaaatccaag atgaatggca aaaaatgcat tatttaaaaa agtgcaggcg atcaaaatat 3314761 agattacagc cataaagagc cgttcttttg ttgtaaatgc ggttgcaagc gtcagtaaaa 3314821 acaggccaat tgccaacacc gcaagcacag cagccatctg catgaaacct atatctttat 3314881 ggatggctcc cagcaatagg acgactccaa atatagcagc ggccagtaac gctagcgtat 3314941 ggaccgctga tcgtttgata ctcacatgtt taaccccttt cctgatgttt caggagccgg 3315001 cggccgagcc tagcagccgg cagcttcaac caagtaacac tttttctttt tataaattga 3315061 cgcttcccaa gtctttagcc aattcttcaa gcggcaagcc cggaaaatac ttgtcagagg 3315121 gttccgttcc ccgaacagcg ggacggccga tagagtgata aatgtatccg gctgcctgca 3315181 tctcttcaag tgaaaataaa tttctgccgt caatgatgac tggctgtttt aagagggttt 3315241 tcacttttac aagctccatt tctttcactt ccggccaatc cgttaaaatc aggcatgcat 3315301 cagtgtcttc catcgcagca tacacatctg tgtaatactc gacctgttcg ccaaggatcg 3315361 ctgaagcttc aggaatagca atcggatcgt atgcttttac atgggcgccc agctgctgca 3315421 gcattgggat aatatcaagc gctggagcgg atctcacatc gttcgtattc ggtttgaagg 3315481 ctaatcccag gactgaaatg gttctccctt tgacgcttcc cataacagtc aaaagtttat 3315541 ctacaatatg aacacgctgc ttttcgttcg tttcaatgac agcttcgatg agcttgaatg 3315601 gatagcctgc cgattttgcg atttgaagca gcgcggttgt atcctttgga aaacatgaac 3315661 cgccgaatcc aataccagct ttaaggaact ttctgccgat acggctgtca agaccaacac 3315721 catcagcaac ttttgaaacg tctgcgccga ctcgctcaca aatgtttgcg atatcgttga 3315781 taaaggaaat ctttgtcgcc agaaatgcat tcgcggcgta tttaatcatt tctgcacttt 3315841 ctaggtttgt tttaatgaca ggagcatgga atggctgatg aagttcctca atgatggcag 3315901 cggctttatg acttgttgaa ccaatcacgg cacgctccat attcatcgtg tcatgaatcg 3315961 ctgacccttc ccgaaggaat tcagggttag atacaacatc aaatgagtat ctcccctttg 3316021 aggctttttg aacgatagat tgcaccagtt tccctgttcc aaccgggact gtgcttttat 3316081 ttacgatcac tttgtagccg ttaagatgct caccgattgt tttcgccgcc gctttgacgt 3316141 acgttaaatc agcttcacct gttttggaca taggcgttcc gactgcaata taaataatat 3316201 ctgaggcccg aatggcagac gggatatcgt tcgtaaaggt caggcgctga tccagcacat 3316261 ttttttcaac taagtctgca agccctggtt catagattgg gattacccca tttttcaggc 3316321 ttctgatttt tgattcatcg atatcacagc aaacaacttt attgccgatc tccgcaaagc 3316381 aagtgcctga tacgagtcct acataacctg ttccaatgac agctattttt ttcacagcgc 3316441 tcaaccctct cctgtaaaat gatcttccaa tttataatgg tcgcagtgtc ttacgattaa 3316501 acggacgttt tcgtgaccgt ctgatactga tgatgcaagg ccttggcgtt ttttcctgcg 3316561 tcaaattgag cctgcacggt ttcatacaag tcatctgcta cttccggctt ccatatttgc 3316621 tcatgttcgt accgagtgat cgcttccgcc aaggcttgag cggatttcgg tttaatcagc 3316681 agatgttggt gctttccgaa taaagacgac actccgccaa catccgtaca aataacagga 3316741 acccttagcg ccagcgcctc aatcacaaca gtcggcatcc cctcactgta agaaggaagt 3316801 acgaatagat ctgccgcaag taaatagtct cttacctgat gattcgggac ttggcctgtg 3316861 acgatatgcc ccttctgcgt cagcgtcgat tttgcgggac catccccgac aaagactgcc 3316921 ttaggagagt cctgcagcga ttcgatcgct tcagacagtt caaaaatgcc tttctctctg 3316981 accagccggc cgacatagac agccagacgc tgatcgagcg ggagtccgag tctttttctg 3317041 atttcctctt tcgtctcctc attcccctga aaacggctga gctgtatgcc gattggcaaa 3317101 accgagctgt caaagcccga aagctttttg gcttcttcct gaagcttgtg gctgactgct 3317161 aaaacaactg acgcagaacc tacggcacgc ttgaaggctt taaacgcacc tttgctgtaa 3317221 tgcggataga cattcacatc actgccatgc aaggtcagga cataaggaat ttgcgctgac 3317281 tctgacacga ctgccgcagc cccgcccgat ggcatggcaa aatgcgcatg gatcagatcc 3317341 ggatataggt cgcgctgttt cattgttttt aaaacggctg atgcgattct ccgatgaggc 3317401 tgcgcccact tcagctggcc gggaactgcc cgatagaaag gccggtaaac cggtatcccc 3317461 tttctaatct catactccgg tctgacatcc ttttttcgat atgtcttttt cagcatgcgg 3317521 acaggtgctg aatgaaaagg ccgtgggcat atcacagtga tatcaagccc gagtttttgc 3317581 agctcttgca cctgtgtctc atgaaacaca ccctctccgg gtttcatact gctcggatat 3317641 acgcttgtga tccacaaaat cttcatgaca aacgtccttt tcttagtagt ttgcttttcg 3317701 tttgagggta cgcttttacc aaaagaaaga gatagcacag cgccccagcc gcaactgaaa 3317761 tggccagccg catttctgcc tgcatactga agtgttcggt actgaggctt acaccaaacg 3317821 cgatgatgcc catcgccgca gtaatcagaa atggcttcat aatcgactgg aaataagctg 3317881 aaaggttaag cttgatgaca tatgccaaaa gccagcgccc aatcaggaaa ttaacaacgc 3317941 tgataatggc atacacccat gcgactgtca gcaggcttcc cgtctgtaca gctgcaaaca 3318001 gtgataatcc gtacagcagc agcacgccgg aatcccaata aaacgctaag tcagctcttc 3318061 ctttagccag caacacagat ccatttggat tcatgagcac tcttagtatt ccgacaatcg 3318121 caagaacatt taggatcgga acagcagcaa gccatttttc tccgaaaacc gctgtgataa 3318181 aggcgtctga cacagacacg agcccgatta acagcggaaa cgaaacaagc gccagcattt 3318241 ttgtcatatt cagaaagcct tctctgatca cgctgttttc atatttgttt tttgcgaaaa 3318301 tagggaatgc cacccgtgtg acaatcggat tgatcttcaa aaccggaatg gtgacaatct 3318361 gataagcgag gttataaatc cccaatgctt cagcaccaat aaaccggccg atcaaaatca 3318421 tgtcgatatt tgctcccagc ctgttcacaa gacgggatga aagctgaaag gctccaaaag 3318481 aaaagaaatc cttcatgcct ctcaaatcaa aaacaaaagc aggatgccac ttttttcggt 3318541 atacagccca atataaaatc cctttactgg actgcagcag gacttgagaa atcacgtacg 3318601 ccaaaatcgc atccatcata aaaaccgcta tcgctaaata tccgaatgac aatacatttg 3318661 aaaaaatctc tattttgctt aacgtattaa aatgcagctg cttttgcagc atatactgat 3318721 attgctgtcc aattggcgcg atcaaaaaca taatcgccag aatccgaacc agaaacacca 3318781 gctcttctct ttgataaaat cccgcaatga caggactgct cacatataaa agaacaaaca 3318841 gcaaaacgcc cgtcataatg ttaagccaat acaatgttga cagctggcgc tccgtcgcgt 3318901 cgtctctctg aattaatgct gcgccaaaac ccatatcgag cacaatctgg gcgaaaactg 3318961 taaccgttgt gatcatgccg acaagcccaa attctgttaa ggtcatcata tttccaagca 3319021 gggcaaactg aacaatttgt atgattgtaa tacacatggt tgaaatactt gtccactttg 3319081 caccgctcat gatttgtttt gtaatacttg gcatcatatt ccctacttct ttttaagctc 3319141 agattgatgg tgaataatgg aatcccgttt tatcttgcac catcacccgt ccaaactact 3319201 ttacaagttt ttaacataat ttttaattct aaagtgaaag tcagattgcg aatgtaatat 3319261 aaatcaaata tcagcttttc cttcggcgtc atatcgtaac cgccgttcac ctgagcccag 3319321 acgctgtgta aagcctggaa tctcattctg gaatttttcc gtaaatacgg gccgttccgg 3319381 acgagggcca atcatactca tatcgccttt cagcacatta aacagctgag gaagctcgtc 3319441 aattctcgtt cttctgataa aagctccgat ccttgtcacc cgcggatctt gcttctgtgc 3319501 ccaaaccgcc ccagacttct cggcatctat tttcatggaa cgaagcttat aaagcttaaa 3319561 tggcttcccg cctttcccta cgcgttcctg cgtataaatg gcaggccccg gcgtctccaa 3319621 acaaatcaaa attgaaaata ccgcaatcat tggcagcgca atcgccaatc caatgagcgc 3319681 aaaccaaata tccattacgc gctttattgc caaataacga gccgtctttt cagataatgt 3319741 aaaagaatgt atttgttgaa ctgagaattc acgactcaca ttcatgcttt tctctgcact 3319801 cactgacaca cacctcacga tttgtttggg atgttatgat gacctatgcc agtcagttta 3319861 gcagacggat gttaattgga tgtaaatggt atgttaagaa gtgtgaatta cgtgtttttt 3319921 ctgataaatg ttgttaatac tcttttacta ttttatatac aagtcctatt tgttttaatc 3319981 atttcatata aaaaagagac aaatctgtga ttagatttgt ctctttcgat tatctgtaat 3320041 aagatactgt gccgtcatga atagcttgtg cagctttatc tttataaacc gcttgcttca 3320101 atttacttgc atctgatgca ttagtgataa aggcagtttc aactaaaaca ctcggcattt 3320161 tagaatattt aataacatag aaagcagctg tttttactcc ccggtctctc gttccaagat 3320221 tagccgctaa ctttggttga atttgttcag ccagtctctt gctatttgca gcttgatatg 3320281 ttgtatcgta gtacgtctca cttccatttg gtgatgagct atcattagca tttgcatgta 3320341 tactgagaaa taaatctgct tgtgcagaag ctgctttatt tactctctcc tgtaaagaat 3320401 aaaaagtatc attagatctt gacagtactg gaagagcacc tgaagcattt agctttgtat 3320461 tgactctttt cgctatatca aggttgactt ctttctcaag gagtccattg ccgattgctc 3320521 ctgaatcttg atcaccgtga cccggatcaa taaagattgt ttcacctaca actggattct 3320581 ttagctgatt agcaaccttt gtgcttacgg caggagtgtt tccgataatc ataaagtttg 3320641 acatgttttt acttccaata attttacggg ctcctgtaga taaattttca ccatttgtaa 3320701 gaataagaga ttgcttcttc ttagctgcca gtgtagctcc tgcaatagag tcagggtagc 3320761 tgaatccatt gcttacatat acggtgcttg ttgataaatt aagtttttgt acgatatttg 3320821 cagcaagctc atatctgttt gaaccgctaa ttcttgtagg agaaggtaac ttgttgtata 3320881 ccgtattgct gatacttcca gtgcctccta caacaacggt actcgaaatt cccttatctt 3320941 ttatcacaga cgtagtcgca ctatttatag atgttttatt tgtaaaaaga attggatacc 3321001 cgtttttcgc tgcataaggg atgacggccg gagcgtctgc atataagaag ccgttcaaaa 3321061 taacagcttt tgaagtcgca cccatcgctt ttgccacccg tgcagccgta tcataacggt 3321121 tgcttcctgc aattcgttta atacttatcc ccaagctttt aatctggtta gcagtgttag 3321181 aagaaacagc aggtgttccg cctacaataa ttacattttt agtctgcatc tctttcaatc 3321241 ttgttttcgt ttcatatgaa agcttatcag aattagtgta aagcaatggc gcattcttct 3321301 ggtaagcaag aggtgctgct gaaatagcat ctgcatagga actcccacca acaattacag 3321361 ctgtacttgc tgttgaatac atttgctttg atatttgtac agcagtgccg tatctattgc 3321421 ttcccccaac tcttttcact gagttatcgg ccaaagctgt tggcacaaaa agtatgagcc 3321481 ccagaaaaca cattgttagg acttttatat aagaacgcaa ttgatttcct ccttaaatgg 3321541 cgttatatcc taaaataatc aataacttgt cagagttgta cctggatagt aaaatttcaa 3321601 aattgaacta tatgaatctc cagcttctgc tcttgctttt gctccatatt gactcattcc 3321661 gatcccgtga ccatatcctt taccgctgat tgtgtacttt gaagtatctt tttttacagt 3321721 cacataagta cttttaaata cagtcgctcc aatcattgtt cttaactcac ttgttggtac 3321781 actaatggtt gtaattttgc tcaagttata ggagccagta ctgcttttaa caaaatactt 3321841 cactttcatc gatgctgttt ttgcacgctg cccttgtgtc gttccactaa agcttaaatc 3321901 gtcaatactt gcaattttga cagaatcagc gcttgtttct ttatttttca agatccagtt 3321961 cttaactccg gaaagtcttg cagaatcagt ttcagtcgct gaagaccacc aagaagaagg 3322021 cttcgttaag tccaaagatt tcgtatctag ctgttgtttt gacaaagtaa gcgtccagcc 3322081 tatttgagga tcctttgtat ctttttttgc aatcaagtaa ggtacacttg acgaccacac 3322141 ttcattacta gcttctgtgt aaccaccatt actggaagaa taagctgcag ttataagaga 3322201 tccattatat ttcagaactt tccccttcgt ttgctctacc gctttattgg tattcgaatt 3322261 ccaactgtag ccaccataaa cttgaaaagc ggttgtatca ggtacagtag ttcctgtttt 3322321 tgttattgag taggttcttg cagcgacagt ctgtgcttta agagcctcaa gtgaccagct 3322381 agcaggcatt tcattcggaa ttactccttt taagtaatcc tcaaatggaa tattctcatt 3322441 taccggtcgg atatatttag tagactcaat agagaaatta accgtgccaa gatactgctt 3322501 tccatcaaga ctaattctgt ttgaagtaga atagttttct ggtttaattc ttagggagtt 3322561 tccgtaagtt ttgatgtttt caaggtttaa ttttccgctg ttgattttta gattataggt 3322621 gccaccgtca gctaaataaa attcatcagc aagtgaattc tcaacttcag cagaaattga 3322681 actggtactt ccaataaagt cgtatgcata tgtggcttta tctttcgtta tacttttagc 3322741 cgcagccgga acgctatctt gtttaacaaa taaaatttgg ctgtttttct tcgaggcaag 3322801 cgaagcgcct atcaatacgt ctgcatattt tgtcccgttc gtcattacga ctttatcagc 3322861 cttcaacttt agttgcttaa ttatatttgc cgtaagttca tatctggttg atccaggaat 3322921 cctttgcaca gttgaagttt ttttaatttg gttttctaca ctatcactga cgctaaatga 3322981 actgcctata atgatgactt gttttggcaa atcataatcc ggaagcttgt ctttctctgt 3323041 aagcaaaata gggtatccgt gtgctgctgc atatggagca atggctaaag cgtcttgaaa 3323101 tactcttccg gttacaacga tcgctttatc atagctgccc atttgctttg caatattttc 3323161 tgataagaca tatctatttt ttccgcttat ccttttcaca gcgccatatg atttcagctt 3323221 gttttctacg tcttttgaaa tgcttcgcgc tcccccaatg attaaaatat tatcagggtt 3323281 aaacttagca atttgtcttt cagtagtttt tgttaacgtg tcaggctgag taaataaaac 3323341 tggtgcgttc agttttttcg ccaatggaat aacaggcaat gcatcaataa aaatatctcg 3323401 gttcaccaat atcactgtat taggattttt ccactggctg ttggatgcaa gagtcgcagt 3323461 ttcgtatcgt gaagcgcctg caaaacgatc cgtaacagca acattatctc cagttacttt 3323521 ataaaatcct gttggcgata gactgatgct agatttattt ccaatataat ttaacaattt 3323581 aactgagatg tttgagtctg ctgcaaaaga aactgatgga atcaataata agattgcagc 3323641 aagtgaacac actatcaatt gtttgcaaga tttcaaaatt tcaggttcct ccctatatct 3323701 tagttggcac gttcaatatc ttttaacaga agctgaccct catcattttt ttcatatgta 3323761 atcgtgacct tatctccact gttaaactta tcaagatcac ttgtcgattc ttcagtgata 3323821 tcaagactaa ccggctcatt atctactgtt acttctattg tatgagtatc agctaaccct 3323881 acataagtac cttcttttgt ttcaatgtta ctgtctggcg atacatcttc accttgactc 3323941 ttttgactat taaccccgca acccgaaaga agcaatataa agaacagtaa agcaataaat 3324001 tttttcattt ttttcacctc attatatttt atcgtcaacc tattttatat tttaaagaaa 3324061 aattaagaaa caatgaaact tttttttata aaaaacgact attttaggat ttcattcttg 3324121 tattaaatag agttgtattt attggaaatt taactcataa tgaaagtaat ttaacagacg 3324181 aggtgcaaag gatgagaaac gaacgcagaa aaaagaaaaa aactttatta ctgacaattt 3324241 taacgataat cggacttctt gtactcggaa ctggcggcta tgcatactac ttatggcata 3324301 aagcagcttc aaccgtggca agtattcatg aaagcattga taaatctaaa aagagggata 3324361 aagaggtcag tatcaataaa aaagatcctt tttccgtctt aatcatgggt gtggatgaac 3324421 gcgacggcga taagggccgt gccgatacgc tcatttatat gaccgttaac ccaaaaacga 3324481 atacaaccga catggtcagc attccgcgtg acacgtatac aaaaattatc ggaaaaggca 3324541 caatggataa aatcaaccat tcatacgctt tcggcggcac acagatgacg gtagacactg 3324601 ttgagaactt cctcgatgtt ccggttgatt attttgtgaa agtgaacatg gaaagcttta 3324661 gagacgttgt tgatacactt ggcggcatta cagttaacag cacattcgcg ttcagttatg 3324721 acggttattc gttcggcaaa ggagaaatca cgctgaacgg aaaagaagcg ctcgcttata 3324781 cccggatgag aaaagaagat ccgagaggcg acttcggacg ccaggaccgc cagcgccaag 3324841 tcatccaagg tattattaat aaaggcgcta atatttcttc catcacgaaa ttcggagata 3324901 tgtttaaagt tgttgaaaat aatgtgaaaa cgaacttgac cttcgataac atgtgggata 3324961 tccagtccga ttacaaaggt gcgcggaaac atattaaaca gcacgaacta aaaggtacag 3325021 gcacgaaaat caatggaatt tactactacc aagctgatga aagcgccctt tccgatatta 3325081 caaaagagct gaaggaaagc ctcgaaaagt aaaacaaaaa gaagcttcgc acaatgtgca 3325141 aagcttcttt tttatttgcc tgtaaatgaa tccggttgtt cttttcgata cccgtaatga 3325201 aacagcaatt cttccacaat ccggcgggaa gcctctccat ctccatacgg attagaagcc 3325261 tgggacattt tcttgtactc atcaggatca gttaacagct gttttgcaag ctgataaatg 3325321 ttttcctcat ccgtacctgc aagtttcagc gttcccgctt ccactccttc aggccgttcc 3325381 gtcgtatcac gcagaacaag aaccggtttc ccgagagatg gggcttcctc ctgcacgccg 3325441 cccgaatcgg tcaatataaa atgcgatttc gctgcaaagt tatggaaatc gatcacctct 3325501 aaaggttcaa tcagatgcac tctgtcagaa tcaccaaaat gcttatgagc cgcttcccgg 3325561 acaacaggat tcaggtgcac agggtaaacg acttgtacat cttcaaattc ccctacaatt 3325621 ctgcggatgg ccttaaacat gttttccatt ggctcaccca aattttcccg gcggtgagcg 3325681 gtcaagagaa tcattttatc ctcacccacc tgatcgagaa caggatgtga gtaaccatcc 3325741 ctaaccgttg tgttgagtgc gtcaatcgct gtattgcccg ttacaaaaat agagtcggcc 3325801 tttttgtttt cttttaataa attgtctttc gcctggcctg tcggagcaaa atgcaaatca 3325861 gcaatcgccc ctgtcatctg tcgattgagc tcttccggaa acggggaata cttattccct 3325921 gtacggagcc ccgcctccac atgaccgaca gcaatttgat ggtaaaaagc ggctaggctt 3325981 ccggcaaacg tcgtcgtcgt atcaccatgg acaagcacaa tatcgggttt gatatcttta 3326041 aacaactcat ccaatcttac aagtgcgtta gacgtaatct ctgccagtgt ctgccgctcc 3326101 ttcataatgt tcaaatcgaa gtcaggcttg atgtgaaacg catctaacac ctgatcgagc 3326161 atctgtctgt gctgtgcagt taccgttaca taggaatcta tttcaggata ttttttcaat 3326221 tcaagcacaa gcggtgccat cttgatcgct tcaggcctgg tcccgaaaac ggtcatcact 3326281 tttagttttt tcatatttgt cacctggttt tctgctatag taaataaatt catactacat 3326341 attctacatg aaaatgcatc attttaaatc atttcattct tgattcaaat aaaatgatat 3326401 aagttttaat attaaggata aagcttgttt aaaaatggtt tatccgatat cataaaaatg 3326461 tgtaaaaaca tattgaaaag ggtaaataga gaatagttta accataaatt ttttcgatca 3326521 taaggaaggt gccttttaaa tgaaaaaagt acgtaaagcc ataattccag cagcaggctt 3326581 aggaacacgt tttcttccgg ctacgaaagc aatgccgaaa gaaatgcttc ctatcgttga 3326641 taaacctacc attcaataca taattgaaga agctgttgaa gccggtattg aagatattat 3326701 tatcgtaaca ggaaaaagca agcgtgcgat tgaggatcat tttgattact ctcctgagct 3326761 tgaaagaaac ctagaagaaa aaggaaaaac tgagctgctt gaaaaagtga aaaaggcttc 3326821 taacctggct gacattcact atatccgcca aaaagaacct aaaggtctcg gacatgctgt 3326881 ctggtgcgca cgcaacttta tcggcgatga gccgtttgcg gtactgcttg gtgacgatat 3326941 tgttcaggct gaaactccag ggttgcgcca attaatggat gaatatgaaa aaacactttc 3327001 ttctattatc ggtgttcagc aggtgcccga agaagaaaca caccgctacg gcattattga 3327061 cccgctgaca agtgaaggcc gccgttatca ggtgaaaaac ttcgttgaaa aaccgcctaa 3327121 aggcacagca ccttctaatc ttgccatctt aggccgttac gtattcacgc ctgagatctt 3327181 catgtattta gaagagcagc aggttggcgc cggcggagaa attcagctca cagacgccat 3327241 tcaaaagctg aatgaaattc aaagagtgtt tgcttacgat tttgaaggca agcgttatga 3327301 tgttggtgaa aagctcggct ttatcacaac aactcttgaa tttgcgatgc aggataaaga 3327361 gcttcgcgat cagctcgttc catttatgga aggtttacta aacaaagaag aaatctaaac 3327421 aaaaaggcta ttggacattc atccaatagc ctttttttat ttcaacatca aagtcaatgt 3327481 atgctcttca ttatcaactg cgaagacctg atcaacggcc tgccgcaaaa attaataatc 3327541 ccagacaaac acactgattg tagagttaaa caaactaaat gaaaacataa atacaaacat 3327601 gcagattaaa tagtaaatat cttgtattca atgcaagcta agtaaacacc acttgctaaa 3327661 agaacaatga ctaaacaacc agcattacaa aataattaaa taaatttgaa gcaattacaa 3327721 cagaaggcag tgaactgtcg gaaagttcat tttggctacc atattaatcc ctttaactac 3327781 gctgttggat ttatcaagaa ttgtcgggct aatagaaaac cacggaatca aaccagccag 3327841 cattcaaacg ataaaaggca cttctccgat acctgttatg accagcttac tgttgcgcat 3327901 cccaaataca aaccagtacg ccatcattag aataagggga tttaaaacct gccataatac 3327961 accaaaataa ttgatttttt ggatctttcg gttaaagaaa tttaaaagta ccagtgaata 3328021 ttgtaacaaa tgttgagttt ttttcacttt taaaaagtaa agagaagtct cgcagaactt 3328081 ctcccaacat ttgaagtgtc aatataaaac aaaccaacct catttagcaa ctttattatt 3328141 atctaattcc aaaatagcat tataaatacg attcctatta tttttatcag tatatgcaaa 3328201 aaagttatct actctttttc tatacttatc ttccatacga ctattgtttt tcatataata 3328261 gataacttta tccactaagc tattatgatt ttctaataca tcaccaaacc ccattttttt 3328321 ataatcataa taatcaagtt taaaatggta tgacttttcg tattgataat aaataacagg 3328381 ttttttctca tatgcaaaat caaacgcaac agatgaaaaa tcagtaatca ttatattaga 3328441 agaattaaat agcatttgat agctgctgtt atagtcggca aactccacat aatcatgctt 3328501 ttcaaagtct acaatctgtt gctgaatatc tgggtgagga aaaaaagtta ttttataatt 3328561 atttttctta gcaaattcga ttagccgttc atcattaatc aaagcattat acctagaaaa 3328621 atattcacta tctttaaatt tcgggttgta cggtcttact ccttttgcct gatctttcgg 3328681 taatacaata tcttttctcc aagtcggcat tattagaagt tgcttttctc cctcactctt 3328741 cttaagatta tcgtatctcg gaaatccacc caacaaaata ttctcttttt tatagttgta 3328801 attccctttc acaatagacc gatattcagg tttggcagaa gtgactaata atttgatatt 3328861 cttgttgtat ttgtttaacc attcagaatg atctgccatt gttattccgt gctgtaaaaa 3328921 gataaactca aagttaaata aatctctaaa ataaatctcc atattaaaaa atggatttac 3328981 aacccatata tctgcatgtg tcgatattac tttggaagag gataaggtta aaattttatg 3329041 tctaaaagat ctgtatggta tgacctttcc atattttttg attctgtcgt aatccttgct 3329101 atcttttttt attataaagt atttttttac cccatcattc ttgttgattg catatttaaa 3329161 gaggtgctcg gcattatcat cagctttgtc ttgtctgtct atgaataacc atactggttt 3329221 tctattaaaa atagtgaaaa catggtgtac cattcttgcc atcagtgcct tcttaatcgc 3329281 tgattttcgt ttttttgatt tttcccctga tttatgtagg gattttaaga aacgaaactc 3329341 ttttataaat ctatttttaa aattgttttt tttgaacatt aattttttat aattataata 3329401 aaaaatataa tcttttttag ccacataagt attatataaa tcgtttgaca aacctgaata 3329461 cttgaaaaaa cgaagttttg tcaacttcct ttttttaccc ttagttataa aaaactcaat 3329521 atgatgatta tctgctagat gacctttggg aatatctatt gaaaaaccgg gatatttttt 3329581 tattacttct cctaaactta tataatcatt atgctgtctt tttatattct ttgcttttat 3329641 ttttgtttcg ccaattttag cataaaactt aaaaccttta gaattaaaca gcgagctcca 3329701 aaagccttct atgtgaatgg aatcctcatt ttcttctaaa atttcaatag ttaaagtttg 3329761 atccgataat ttcgaaacaa ttttaccttc tctgtataaa taataatcct gttcagtttc 3329821 tctttcatat acatacctac tataattttc accgtgcttt atttttaaag catgatataa 3329881 atagaaatgg ctgacacttt ttgtttcaat gatgacatcg tcgtcaatat acgacaatac 3329941 ttctcgaatc aatgttaaaa attcactgta ttcattttcg tctaaaggtg tttcactgat 3330001 atccttaatc aataatttcc acttcaaatc atgcataacc atatattgaa gaaataaagg 3330061 tattttctgt tcatgatttt ttataatatc gattaaattc tttgagaaag tgataagtga 3330121 atggttaaac caattcttat ttgctttagc agtctgcatg gcagatgatc catcttctct 3330181 aactctataa tggtattttg cctctttaac cagaccatac tttttctttt gcgatatgat 3330241 taaattaact agtttggcat cttcacctat tttacaattt tcatcaaacc tgatattttt 3330301 caaggcatct ttttttataa atgtagaaca acaatgagtt aatatatgat gcggttcttt 3330361 ttctacatcc aaaattcttg tagaagaaaa cttattattt agattatgtt ctccagttct 3330421 tccttctgca aaaaaaatag ggattgctac aatatcaatt tcattcttat gttcgtcaaa 3330481 gaagtttaaa acattttcga atgttccttc tgaaactaaa tcatccggat ccaaaaattg 3330541 aatatatcta ccttcagcat actttaaacc ataatttcga gcactgctca ctccgccatt 3330601 ctgtttcttt gcatagacaa tgttattggg atatttctga gcatattctt tacaaatgat 3330661 ttcactttta tcggggctat catcattcac cagtattaac tgaatattct caaaaccaat 3330721 agtttggtta atgatacttt ctatagcttc agtgagatac aactcaacat tataaatcgg 3330781 cattataaca ctgaaatcat agttaaaact tttttcgttc ataaaagatt actcctaaca 3330841 taatgtttat atgaataaga attcgggtaa ataaaattaa gaaacaagag agtactaatt 3330901 tttgcaaaac aattttaatt tagtaaaatg tatgaaaagc attccttacc tttttttaaa 3330961 aacccttgta agcaaacttt taaaaatgtt cacatggtta agttctaaag aatcatttgg 3331021 tgtttttagt acaaagtcaa atgcaaaggc ccaaatcggt atttcgacaa caaaaccagc 3331081 atatctaaaa tctcttaatt tatatcccca tacttcaatt gtttttttca gttcttttcg 3331141 tttgcatttt tttaatcttt taaaatattt tatatatatt ctgtcatttt ctttcatctc 3331201 ataatactgg ttaataaagt gccctgttaa ttcaagtcta agccctttta tttttgccga 3331261 agtaacagta catgaactat gcagtactct ttcttttttt atattttcaa gagcttctgt 3331321 attttctttt aataagtgaa acataaattc tttatagtac atcggcatat cttgttcttt 3331381 tataaattgc gggtcaataa attttaaaac tttaataaaa tcatcaacaa aaactctttg 3331441 ttcttgttga tctaaaacag acttataaac atctctatag ttcggatata aaaacagttt 3331501 tatatgatat acaattaaaa attgcaaata aggcaaaact atatcatatt tgttgaatga 3331561 atccatcaac aaagtcatgt aacattcatt caacaaatat gtgtaccttt ttttgttaaa 3331621 ccatgaacga tcaactaaag aatcctgttc tttccgtttt ctataaaaat actttccttc 3331681 tgcaactgct ccgtatcttt tttctttcag taataactgg ttaaaaaaga tagcgtcttc 3331741 ccaaaacttt atagattcat caaaaaggac ggtactagtt agtgtatgtc ttctgtaaaa 3331801 agtgccgcca atataaaaat gaatagcttt ataatcgttg agaatattta taactcttgt 3331861 tcctttttca aatctattat ttaatttatg tcccccttct ttttcacctg tgtaataaac 3331921 aggtaatacc gcaatattta catgttcgga atcacaaaaa aaatcataaa cactttgcag 3331981 cgcattttga gagaatgcat cgtcagaatc aagaaaacca ataaatttag atctttcgct 3332041 tacatttgat aatccacaat ttcttgcagc agaaggtcca gagttttcaa ttttcatgat 3332101 tttaatatta ttaggatata gatttttaaa ggattcacaa atttgaggac tgctgtcaac 3332161 actaccatca tctattaata tcagttctat attttcctta aatccaattg actggttaag 3332221 gacactctct attgaatatc ttaaataatt ttcagaatta tatattggta taattataga 3332281 aaacatgttt gtacctcttt atttagaagt taaaggatcg tttcaattac tcttttagaa 3332341 gccttgcctc ttctaaatta caaaatttat tataaaaatc ctcatagtta tgatctatat 3332401 aaggattatg taacaactct tttaccgtat ctataagttc ttcacttgtt tgaagcaagt 3332461 ttcctggcgt tttttgctga aaattaaagt aaaaacctct gatacagtct ctataagccg 3332521 ggagatcata cacaaaaaat acaaggtttt tttaaaaatt catattatca aaaaagacag 3332581 aagaataatc cataatcaat aaatcactaa ttaaatataa atctcgaata tctttattta 3332641 aagaaacatc gttcacaaaa tatttatatt tccctaatta aattgttctg aaactggata 3332701 ataccattct tacaagaata accatagagt ctccaaggtt ccctcttcat ttcctctaat 3332761 caaattaaag ttaaatttat actggccagc tttcttaaaa ttcattatcc cgcaaagttg 3332821 gtgcatataa aattattttt ctttaattcc ttatttgata atgtagaatt ggtaggggat 3332881 tgtagctaaa ctgtttccag aatagctttc aaataaaatt aatttattgt ttcttggcag 3332941 aaggacaaaa attttaaaca aaactgaata aactctaact agtaaacttc tgcaattggt 3333001 tataataaaa atttcatcag tgaactcctt aaagagtgaa gattaatatt tacgcaaaca 3333061 agaaaaaaag aagcaactga atttacttca agcctctttt agttagtgct tctataaact 3333121 agccatatct tttctgattt gggtagttga aatgcctgct attcttgtaa ggtaaatggc 3333181 ctcatagtat tcctttgtag acaatcgtac gattaagtaa tcccaggttc ttttgctctt 3333241 tccagtagct tcatatgtcc atagtgaaat aaatcaaaca ttccgtacgt atcactttct 3333301 tcattagata acatcacctt ccaacctttt ccaacttaga aaaaacaaaa atccttaact 3333361 gattgtttat catttcgaca tattttttac gttccattaa taataaacaa taatagcata 3333421 tgttcctata aaagttaagg ctctttaaaa atgtaaatca tcagcacttt ttgacaatat 3333481 cgttgcattg atgtgtattt tttacagatc tgatatctta tctatactca ttacaacaag 3333541 ttttctattc cggaagagtc aattcttttt gtcgcgtttt caagtgtaat gattttcttt 3333601 ctgctgcgtc atttattttg tacgccctcc tcatattact tcatcgtcaa aacgtgaagg 3333661 aattgtaata cgtagttcct aaaaattttc gtggtaaaat ttagtgaagt ctttatcagg 3333721 ctaagggact ttatctaaac tacgaattac atatggagat atatagatga aaaggagggt 3333781 tgatatgata taaacgaaaa tcaattagat aaaggaaaaa ctgaacactt ctgaaaaaag 3333841 tgataagttt ctttcactat atcctccaaa aagaacctaa aggtcttgga catgctgtct 3333901 ggttcgcgcc taactttatc ggcgatgagc cgtttgcgtt tctgcttgga gacgatattg 3333961 ttcaggctga cacaccaggg ttgcgccaat taacggatga atatgaaaga acactttctt 3334021 ctattatcgg tgttcagcaa gtgcctgaag atgaaacaca ctgttatggc atcatcgccc 3334081 cgctgacaag tgaaggccgc cgttatcagg tgaaaaactt cattgaaaaa ccgcctaaag 3334141 acacagcacc ttctaatctt gccatcttag gccgttacgt attcacgcct gagattttca 3334201 tgtatttaga ggagcagcag gttggcgccg gcggagaaat tcagcttaca gacgccattc 3334261 aaaaactgaa tgaaattcaa agagtgtttg cttacgattt tgaaggcaag cgttatgatg 3334321 ttggtgaaaa gctcggcttc atcacaacaa ctcttgaatt tgcgatgcag gataaagagc 3334381 ttcgcgatca gctcgttcca tttatggaag gtttactaaa caaagaagaa atctaaacaa 3334441 aaaggctatt ggacattcat ccaatagcct ttttttattt caacatcaaa gtcagtgtat 3334501 gctcttcatt atcaactgca aaaacctgat catctgtatt cacaagaaaa cgcttcttgc 3334561 tgctgtcata caatacatcg ctatcactta aggatagtga cgccgggttg ataggagaaa 3334621 tgttatgaaa aataagctct gttgctttat cattctccag tacataactg attttttcat 3334681 aatcaaaatt cagcgttttt ctgccgtcag ccttatttcc ttcagtataa ccattcaatt 3334741 tcgattgaat gctggtgctg ctgtctccta ggaatttcag aaagtattca taggaagatg 3334801 ctgcgttttg cgagacataa gacgtaaatg cagtggcatg caattcagcg tgtttcatgt 3334861 tagttgcaac agcgctctgt ttcacataat aagagtgccc gtcaaacttt attttcgctg 3334921 cttgtttgcc ttttgcagct accgttactt ttgtaccgaa tggcagtgta acgtcagcct 3334981 tctgtttcaa accctgatcc ttataagcag ccgctttttc atttgctata aacccttgct 3335041 tattgattgc agttaagcgt tcctctgact tgccctttgc atcgccatga tggttcttca 3335101 cttcattttg cggaatagcg ccaaacgaag caattgtacg aagcggggca ttaaagaaca 3335161 tcgttcccgc catgaagaca gtcagaatag acaaaatagc aatttgaatg gcattggcca 3335221 gtgatttcgg ctttttcttc tttttgcgga aacgggcaaa cgcttcagga tcttctttct 3335281 tcctctcttc tgtctgctct tttttatatg tctctttttc ttttttcgat agcttattaa 3335341 accagtcaat aaacgctttg tactctttca caaccgtttt tgtttcatca aacatacgaa 3335401 gctcgccata gtgcatccaa gcaacacggt cacacatctt ttcaatctga ccgattgagt 3335461 ggctgacaaa gaaaatcgtt tttccttgct ttttaaactc atttattctg tctacacact 3335521 tctgataaaa cgtttggtcc cccacagaaa gagcttcgtc aataattaaa atgtcaggat 3335581 caatatgcac ggagatcgcg aaaccgagac gcgacttcat cccgctggaa tagtttttaa 3335641 ccggctgatt aataaaatcg ccaatctcgg caaattcaac gatgctgtca tacatatcat 3335701 caatttcttt attggttaac cccatcatca aacacttgag ccggacattg tcccggcccg 3335761 ttaattggtt attcaaaccg gcagcaatcg caatcagcga cggctggccg ttcatttcaa 3335821 tttcaccgct ggtcggcgga ataattttag ccagcaggtt agacatggtc gattttcctg 3335881 acccgtttat tcctacaaag ccgattgtct ccccttcata cacgtcaaag gagacattcc 3335941 gcacagcaaa aaaaccatta tccttagccg gaaaaaacaa tcctttaatc ttgtccgatt 3336001 gttttttata caaatgatac tgctttgaaa catttcgaaa cgaaactttt agtttcatcg 3336061 taaaatctcc ttacgtatta aagaaagtca acaaacttgt ctctgaattt catatgcagg 3336121 atagaaccta ctaacaataa aaggaatgtg aacaaccaaa agtacagcgt gtacttcatg 3336181 tcatggaaaa accatgctcc atctaagaag ctgttccgga atccttcaat aatatagaat 3336241 agtggattca acttcagaac aggcactaat tcggggtggc tttgaccgag tttcgcatta 3336301 acatcccaaa aaattggcaa caagaaaaac aaaagtcttg ttacggcctg cagcaaaaat 3336361 tgataatctc taatcagcac actgatcgtt gagttaaaca aactaaacga aaacataaaa 3336421 gcaatcatac agatgaagta ataaatatat tgtaaccaat gcacactcgg gaacacacca 3336481 ttaactagga gtacaatgat ataaatcacc atcatgatca tataactaaa taagttagat 3336541 gcaattgcca cggacggtag agaactaatc gggaagttca ttttagccac catattaatg 3336601 cgcttaaata cactatttga tccatcaagt atagttggac tgatgaaaaa ccatgggatt 3336661 aatcctgcca gcatccaaat aataaaaggc acttcgcccg ctccggttgt cacaggaccg 3336721 ccctttctaa tccccatacc aaatacgaac cagtaggcca gcatttggat aagcggattt 3336781 aagaactgcc ataagacacc taaataattc atttgatatt tagacttggt ttcataagcc 3336841 gccaatctta aaattaaagg aaatgacgtt atttgctctc tgagtatacg caacaaatca 3336901 ttcatttttt atcttcctta gacttaattg tttttgggaa tctttctgtt taaaatttga 3336961 aagcaccgct gattattgta acagatcctg catttttttt cacttctcaa caagtatcta 3337021 aaaagctgcc gaaaaatcga cagctataca ttttataaaa taacctaaat tattcagctt 3337081 taaatacagt attaacaacc ttttcagatg aacgtcctga ctctaaatag caaaacttat 3337141 catagaaagg accaaaagaa accggaagct tataatcagg cgatgagatc tgcttgatag 3337201 cctcaatcgt ttcttcagta gtttttacca aaggaccagg agcttctttt tcaaaatcaa 3337261 agtagaaacc acgcaacttg tcccggtagg tttcgatgtc agggacaaag aatagcattg 3337321 gccgttttaa atttgcaaaa tcaaagaata ctgaagaata atcagtaatc agcaaatcag 3337381 aaaccatata caattctcga atatcctcat aagcagaaaa atcatatgca aatccttcaa 3337441 aaggacctaa atcaaaattc tcagctacca gataatgcat tcttaagatt acaatatatt 3337501 catttccaag ttcttgtcta agttgatgca aatctaaatc gagatcgaac ttataacgcc 3337561 cttttgcata gaactgatca tctctccatg taggggcata taaaataacc tttttatcac 3337621 gaggaatatt taacctactc tttatcaatg atattgtttc ctcattatta tcattatgaa 3337681 gaaaatcatt tctaggatat ccagattcaa tcattgtctt gttaaactga aacgcccgtg 3337741 taaagatctc agttgaataa ccatttgggg aaatcaagta atcccaatta gaagcttcct 3337801 tgataaaatt ccttttatat tttttggtgt ttgtaccagg catatggact tcttccatat 3337861 ccattgcaag tctttttaaa ggtgtgccat gccatgtttg taaatatgtt gtatgactag 3337921 gtttcggaat ccataatgga agccggctgt taacaaccca atactcagct cttgccatag 3337981 cgaagagcca ttttaatgag aggcgattaa tgtaaggaat tcccttttca tcaaaaggcg 3338041 ctgaatattg tttatttaca ctccaataca ttttatactc agggtggttt tcccgcatat 3338101 attcgtaaat cgctctcgga ttacaactgt attgtttccc attaaaactt tcaaaaatga 3338161 ctgttttcct tttaactggc attctgctag ccatcatgaa tagagatttg tatgttttag 3338221 tgattaactt gtttctcatt tttgtgatct tttttatttt tgatactaat ctcttcttct 3338281 ttcctttaat aaagtatttc atccttgttt tcaggctata gtcgtttact ctgataccta 3338341 gagtctgctt tttctttttc ttaaagactt cataacgaac tggtgcgttg tttgttttaa 3338401 taatacttac taatcctttt aatttgtttt ttcgatctcc taaaacaaga gcagtgctgt 3338461 tgaactgaat atccgttcct tcatcgtcat tgcatatata ctccataaaa agacgataaa 3338521 cataacgttt ttcatttgag aaaggaattt ctttcaaagg cactttcact tcaaaatcat 3338581 acagttccgg aacaaaacca tctgctctca tgttttccag gccatgtgtt tttctttcta 3338641 gcttgattgg aaatttttcc tcaataggtg tttctccacc cttttttaaa ataaggttca 3338701 agttttttat ccgatattga ttttcggaac tcaggtaccc cgcataacct gttatgctta 3338761 tttcttcaga gctaatctcg atttgatcaa atctgatgat tttggcctct cttttcacct 3338821 taatagaaaa gttgccttta tcagttgtat aaggtaaaat caaaagttct gtggtttgat 3338881 cgacatgaaa ggcgcgctca attgaattta cttcagcaga aagacgcttc aagagtggtt 3338941 cctgctccgc atcttcatat ttttttcgaa attcgacata aaaatcatat gtttgtccca 3339001 tttcaacagg cataggcaaa acatgagcat ttatctcagt tttatactct aatgagccag 3339061 tgttttgaag cggaaattca gattccgttc ctgaacgtct ctctttcagc tttaaaaata 3339121 actggtaatc ctctaaaaat tggtgttctg aatcaattga gattaacaat tcaagacttc 3339181 ctaaattgtt tttcaagctt ttcaaaatac atttaatcac agtgttttca atcattactt 3339241 ttttctgctc ctctgtataa aagctctttc ctttttgctt ccttttatta gtgtcaacta 3339301 ctaaggacat taactctctt ttatttccgt gaccctccaa gagaaattgc ctttaactgt 3339361 tgtatagggc tctactctat agccattatt agtatctata ctgtttcctg acaattttgt 3339421 ttcttcactc gaaagtcttc gcattgtttt aatatggcca tttgcattga aaacaatata 3339481 aaaatcaata acttgggttt tattagcagc tatcttttca atatttacat ctttttcgag 3339541 atcaattaca aacagttgat cattttgtaa gtttgttgaa ataatttcag ccttattctt 3339601 tctgtccaag cccactaaac gtattttttt aatatcatta tgatcaaaat tctcaatgtc 3339661 aatttctatt ttagttttat caaaatcctc agtataggaa ctaatagaag gatctttttt 3339721 tccaaccttt ttagagaact tctctctttc tattcgcacc tcaatcatct gattaagagc 3339781 aaaagcccaa ttttcaatat agttgggtct tgaatatttt tcagccattt taaaagcttg 3339841 ttctgaaaat ttttgatgag tactttcatc tttcatcaaa gagataatag cttgacccaa 3339901 tttctctata ttatactgtt caatgacata tccatttgct ccgtcagtaa ctaagctcct 3339961 tgctccgtaa tcataatcgt atgttacaac tggacatcca ttgctcagtg cctccatatt 3340021 tgatagaccg aacccttcaa aatgagaggt tgaaatggtt agccaagctt tttgaaactc 3340081 tgagtcaggg ttatccgtat agcctttcaa aaagacattg ttctgcagtt tggtatcttc 3340141 aatttctttt tttatttttt cgaaatcttc acccgatccg aatatatcaa gttttgcttc 3340201 aggaatttct ttcacgacta aactaaatgc ttttactgca tgtatcagat ttttcataga 3340261 tgcaagtctt gaaataatga cagctttgta tttttcactc ggcacattca atacagcggg 3340321 atcaagaggc ttatcaattg tatgcggagt aaagaaaaac gtctcttgtt cccctgaaat 3340381 caatttaaaa tcttctagct gctcctcagt tataaaaaag acagcatcca aattatacat 3340441 ctgactaaat acttctttat agcgaccctt aatttgatat ttattgctgc cgtaatgctt 3340501 gttatgaata attgctccat aataggaaga aggtgatttt ttcactttaa agacatgttt 3340561 gtcttgcggt ctgctgtcca ctaaaaacaa cttaggttta tcattttgtt tttgcagata 3340621 ttctatccaa tattgacgca gttccgattc atcttttact tttatctcac cctcaaggga 3340681 gtaccaaata atatgagata attgaacatc tttttcttca ttgttccata catagagttt 3340741 gtctaaatat acttgatttt ggtcattaat atattcctgc agatacatct tgtttagctg 3340801 cacatcataa tgagtaacga gaactaagtt tccgttcttc gtatattcct ctctctttat 3340861 gagctggttt ttatcattcc aatagtcgac gtaccggata gtttctccat ctccgtagta 3340921 aactacagac atttcattgt tcttcttacc aaacaatctc aacagagttt ttgcaaattt 3340981 ccccattcca acttgctttt ttatctggtc aaggcctatc ctttcttcgt atgatctttt 3341041 cccatttgtt ctaacactta aaaaatcatc gaatagatta ataacacttg tgaatttttt 3341101 atcaatctta ccgttgctgt acaattcatc aatttttgaa gacaactcta aatcaaaacg 3341161 aaacgttaag aaaaaggtgt tttggttaca ctcttctcca aataattttg aacgcaataa 3341221 taatgatttc gtcagaccgc cataattact tggcagtcca ccagagataa aataataatc 3341281 catgtcagga atttgtttta tattagattc actcaccgca tgtaaagaca attttttact 3341341 ccctttcggc atctagaata tatgatcatt gaaatttata tctacccgga tactttagtc 3341401 acaaaaatca atgtaagcat caaaaagtac ttcttatttc aataagaagt actttaatta 3341461 gatattgaac caatgatatc aggatcctaa attataaacc agcaatttcc tctttgatct 3341521 ttgttgtaga gatgccttct gttcttggga ggtaaacaac ctcacactga tctttgagaa 3341581 agtcaaattt accttcccag tcatccccca taacaaaaac atcaatatta tgatcaataa 3341641 tatcttgctt tttttgctcc caattctttt caggaattac ttcgtccaca tatcgaatgg 3341701 tttctaaaat taatttacgg tgctcatagc tgtgataagc ttttttttgc ttttgtaaat 3341761 tgaattcatc cgttgaaata gcaacaacta aataatcacc aagctgcttt gcacgctcaa 3341821 gcaatttaat gtgaccccaa tgcagtaaat caaaagttcc atatgtgata acttttttca 3341881 tttaaagaaa cgctccttcc taatgttaaa cactattaaa aacactactg acgttagcga 3341941 ttaaattcta aaaacctgtt tgtattcctt atatcgacat atttctcgta tgtcttcact 3342001 gatcattaat tatagcatac cgcctaaaaa aggttaagta ctcatgagga gaaaaacatt 3342061 ccaaaatatg taattacact cagactccat tggcaccaag gtctgttgtt cattcgttca 3342121 ttcaattgta aaattggaaa catatttaaa tttaatgtaa agataatgtt aatcctttgt 3342181 tgaagattta tgttaaaata taaggtagct tgattttgct tttagaaact ctcggttttt 3342241 aactatataa atagaatctt aaaggaagga ggagccagac atgcaaacag agactattca 3342301 caatattcct tatgttaaca gtaacttaac atcatttatc gattacctag agaaacatta 3342361 tattgatcaa aagattggtg ctgtcatttc cacagtcaac cctgaaattg catttgcagc 3342421 tattaaagat cgggactact ttgatgtact atcttcttca aacttcattt tgcctgatgg 3342481 gatcggtgta gtcatgatgt cacgtttgac taacaacagg cttcagtccc gaatcgcagg 3342541 ttacgatgtt tttaaagaac ttctgggcgt tgctaacaaa aagaaaaaac gcatatttct 3342601 gtacggtgcg aagaaagatg ttataaaagg tgttgtatcc aaaatttctt ctgaataccc 3342661 aaacattaaa atcgcaggtt attcagacgg ttatgttcaa gatcgcaccc tagtggcaaa 3342721 acaaattgca agagcaaatc ctgacatggt attcgtagct ttagggtatc ctcatcaaga 3342781 gaaattcatt cataactaca gacacttgtt ccctaaagcc gtatctatag gtctaggagg 3342841 aagctttgat gtatttagcg gtaatgtcaa acgggcccct tcctggatga tacgtttaaa 3342901 tttagaatgg ttctaccggt taatcttgaa tccatggcga tggaaaagaa tgcttagcat 3342961 cccaaaatat gctttaacgg ttttaaaaga agaaaaaaac aaaaaaactt tctatccaaa 3343021 gcctgaaaaa gatcatacaa aacagattta aaaacaaaac tttcaaataa atggatgata 3343081 aaaatgaaaa taagatcact actggcgaat tgctatttgt attttttatc agcaatcgcc 3343141 ttttttctgc aatgggtgaa acctgaaagc aaagtgaccc tcctgatctc attcgaagca 3343201 aacgcaaaag cgattcttga ggaatatgaa caaggacaat actcttataa acttaacatc 3343261 ctgtataccc agcaggcctc tgctattgcc gagagcttcc cgaatgtaga tgcatattta 3343321 ttacaagaaa aaaaccctat ccatctcatt aaagctgtat acctaatgtt taacagtaaa 3343381 gtgatcataa cagataatta ctttctatta acaagtgtgt taaataagcg gaagcaaacg 3343441 aaatgtatcc aagtatggca cgcaaatggc tcactcaaaa aatttggttt ggaagacatt 3343501 acaaacatgc aacggacgaa aactgatatt aaaaggttcc aaaaagtata cagttcgtat 3343561 gattatttaa ctgttggctc agaagagatg gcaaatatct tcaagaaatc atttggaata 3343621 aaggataacc aattattaaa aataggtgta cctttaacag acccttatta ccgagaaaac 3343681 aagaaaaaaa tttcagatac tctaaacata caaagaaaaa aaataatcct ctatgcaccg 3343741 acgtttagag attataatat gcaatcaatt caattgcctt ttacagaaga acaattaatt 3343801 catcagttaa aagaagaata tgttttattt gttaagctgc atcccgccat tcagaacaat 3343861 attgatatta aatattccag tgattatatt aaagatgttt ctaactatgc cttgtttgat 3343921 ctactcatgg ctgcagacat attaatcact gactattctt ctgttccctt tgaattttcg 3343981 attttaaata aacccattct tttttatact tacgatttaa aactttatca acagaagcgg 3344041 ggattggttg ataattatct ttccataata cctggaagag cctgctatga cagtgaatca 3344101 ttaataaatg aaattcaaac cccatttaat tattccaaaa taaaagtttt ttccgataga 3344161 tggaataagt attctgatgg gaattcaagc caaaatttat tgaatttcat cgaaaattta 3344221 ataagctaaa tgatgacact tgttcaaaac agaacaagtg ttcttttttc tattgaatac 3344281 cgaacgtatg tttgctttaa tgtaattagt tgcttatggc agcaaataat aatagaggtg 3344341 gtaaatttat gagaaaaaaa gaactgtttg atttcaccaa catcacgcca aaattattta 3344401 ctgaactacg tgtagcagac aaaaccgtac ttcaatcatt caatttcgat gagaaaaacc 3344461 accaaattta tacaacccaa gtcgcaagtg gattaggaaa agacaacacc caaagctatc 3344521 gcataactcg tctatctctt gaaggtttac aattagacag catgctgttg aaacatggag 3344581 gtcatggtac aaatattgga attgaaaacc gtaatggcac catttatatt tggtctctat 3344641 acgataaacc aaacgaaaca gataaaagtg aattagtttg tttcccatat aaagcaggcg 3344701 cgactttaga tgaaaattct aaagaacttc agcgattctc gaatatgcct ttcgatcata 3344761 gggttacacc tgctcttgat atgaagaata gacagttggc aattagacaa tacgatacaa 3344821 aaaataataa taataaacag tgggtgacaa tctttaacct ggacgatgca atagcaaata 3344881 aaaacaatcc tctttatact attaacattc ctgacgaact tcattattta caaggtttct 3344941 ttttagatga cggttattta tattggtata caggagatac aaacagcaaa agctatccga 3345001 atctcataac tgtatttgat tccgataata aaatagtgct gcaaaaagaa attactgttg 3345061 gcaaagactt gtccaccaga tatgagaata acttccgtga accggaaggg atctgtatgt 3345121 acaccaatcc tgaaactggg gcaaaatcat taatggtggg aattacaagt ggaaaagaag 3345181 gaaatcgtat aagcagaatt tatgcatacc attcttatga aaacttcatg aatcatgtac 3345241 ctatgcttcg atccccttta ttaaaaaccg tggggcacca agatacacct ccagaaagat 3345301 ttcaaccatt tattcaaacc ttcattttag agtataatgc tcaaaacaaa aaatggatgg 3345361 ttccgacttc aggttattta ccatcttaca catcaaattt agtccgaaat attactatca 3345421 atgcagatgg aaacttgcaa gtcacattaa atgaacgcta tattagttta ctgcatcaat 3345481 cgatagaagg agatttccgc ttaaaacaaa aggatatccg aatgggatcc tggtattttg 3345541 ccggcggaga aaaatcaaat gtgcttgaaa taggttttat gaaagggagt acaaaaatca 3345601 gacccgatga tgcagccatc tcaaatgctt caagaatgag tatttttatg attgttgcgg 3345661 acaagattga ggtgtgataa tcaaataggc tgtagctatt taatagctac agcctatttg 3345721 caactttcta agttttttat cgatattccg gaacatcaaa ataaagtgta taaccgtcca 3345781 gcaatgaata caggctgtac atgcggttta cttgtttgta cgcccagccg atgtctgttg 3345841 cgtattgatg tgtcgctgta gctgaccatc tcattttgta cagtgtgtct tgattgtaag 3345901 ctgtgttgtg gatatacgat gagcctatga atttagctcc gccgataatg gccgcttctg 3345961 gtgtgaacca gccctgctcg tacgcatatt tggctccgta gtaattcgga ttgctgtcgt 3346021 atgctccaat tccatacatg ttgtatacgg tttttccgtt ataggttaat ccattggcta 3346081 aagcggatgt cccgtttcct gtttccagaa gagcgtgtga gattaaatac agttcgttga 3346141 tgctatattg attggcggca tcgataaatg cctttgctct ccctgtcagg atgcctttac 3346201 ccgcaagcac tttctgattt acctcagtaa cgctgagacc cgctgtctgt gacagcttga 3346261 gaaattggaa gtagtatttg ctgtctctgg aaaagttatt cggatccacg tattgaacta 3346321 cttcatcact gcttgcgttt cgccagccca aattgatctt agcccagccg tttatctgtc 3346381 cgatgacttt cactttatcg ccttttttaa actggccgat cacgtttgtc gggctgactt 3346441 ccggcgttga ccggatattt agtacatcag ccgtaacagt tgatgttgct gtattaatgt 3346501 acgtgagcga tacgtaagcc gctccgtctg tttgcggact tactgtcatt tgtttttgga 3346561 ccatatcacg aagcgagaga ttgtagtttg ttttcatgat ttgcgggccg tttttgatct 3346621 tcacgataga tgatgtccat ccgtataatt gttttagctt cgttgatgcc gcagcagctg 3346681 tatcattgcc tgtgaactgc tcatttacgc tgattttata aagcgtattg cttttcgttg 3346741 tatagctcgg ggttacactt ttcgatttaa gataggttaa cccattgttc aatgcggttt 3346801 tgctgctaag ctgtgttgtc acgattttgt attgtgtata tgcagtctgg cctgtttttg 3346861 atgttgtgac tgcgatatga ttttgtttga aaaatgttaa aacgcggtca atctcttctt 3346921 ggctgatgat agcttcagtt gtgatttgat agctgctcgc agctgtctga ccggttttct 3346981 ggcttgctac tgatatatga ttcgatttga aaaacgtgag tgcctgattg actttcgttt 3347041 gatcaagcag agattcggtt gtgattttaa acgtgtcagc tatttgtttt ttgacggatt 3347101 tcgcagaagc acttagctga tttttcttta atatgttcaa accctttgtg acttttgctt 3347161 gatctgatgt ttcttctgag atgagctgat attgattttc tgctgttgat ccagctgctg 3347221 tttttgcagc ttttactttt ttctgagcaa agaaggctgc tgctttgttt gcttgctgct 3347281 cgcctaaaat ctttgccgtc gtgatttgat aagctgcaga cgttgtcgtt tttttgacgc 3347341 tggatgacgt gtaatgccat tttttctttt taaagaaagt gtctattttt tggagctgct 3347401 gttttgttat acccttcata ttcacggtat atgatgtgct ttttccaacc tgttgataac 3347461 tgccggatac gccagtgttt ttcttgattt ggctgatggc gtcctttact gtactcagcc 3347521 ctttgaaata agctgattgg acattgtatg actcaacggt tgttttttga ttgatggact 3347581 tgtagctgcc tgtgatgcca gtgctctgtt tcagctgctg caatagagtt ttggcattgg 3347641 cttcacctga aatggcggca gttgtgaacg tataataggc ttgccctttc actgtttcct 3347701 ttaatgatgc ctgcagccca gattcctttt ggaaggcgtt tttgatctgc gctgctctgc 3347761 tgtctcccac gattgtgcca gactgaatgg ttgtgacaga caccgtgtgt gtgatgggct 3347821 gatacgagct tttaatcccc gtttgcttgg ccaggctctg gataagcgcc ttgacttttg 3347881 tctcatcagc aatgtctgat gtcatgacgt tcatataggg ctgagctgct ccgtaagctt 3347941 ttacagcgcc agccactccc gtctcctgtt tcagctttgc taggatagtg ttggcctgtt 3348001 tttctccgga gatggcacct gacgagatgg tgacatatgg ctgtttgctt ccaacaggac 3348061 ttgacgttcc tgtaattgat gtctgtttgg cgagtccgct cagtattgct ttcgcttctg 3348121 attcgctatg aatgcctgag gcggaaattt ggtaggtcgt tgttgtgcct gaagcctgat 3348181 aggatgcatc ccagccagta tctttttcca gtttggcgac agcttgtgag gcttggcttt 3348241 ctgtactgaa cgtattcgac ggctctactt tatatagtga gtagtcggta tacgcggctg 3348301 cctgggcaga accagacatg gcaaaaaagg caagggacgc ggcggataga agcataggtg 3348361 cgattagtct ctttttcatt ccttctcctc tttcttattc tatgagtata taaaactagt 3348421 ttatttatcg gcacgcgcat gcttcattta taggtgaatc acttccattt tctaataaaa 3348481 aaacttaacc tcgaagtgag attaagttta aatatgagac acgataaggg tacaagttcc 3348541 ttttatcgta aaatcgggca tttgagccgg caaaataaag tgatcacctt ttttgagcgg 3348601 acatgttttg tcctcatact tgagcaaacc gcttccttct atcacgctgc aaatcagaaa 3348661 ggattcatcc tgagccattt cagcttcgcc attgatgtcc catttataaa ccgaaaaata 3348721 ttccccttgg acaaatgttt taatggttat tccttttctt gattctgtcg attcatctat 3348781 atacccgtcc acatggggaa ccgtggcggc attgaccgct ttggcaaaat gaagctctct 3348841 cggacttccg ttgctatcaa gacggtcata atcgtacacc cggtatgtgg catctgaatt 3348901 ttgctgagtc tctaaaacaa gggccccctt gcacaatgcg tgcagcgttc cgctcggcac 3348961 ataatagaaa tcacccggtt taattttgat tcttcgcagc aggccctccc agtcaccgct 3349021 gttgatcatt gtgacaagtt cggtttttga gcgggccgta tgcccgtaaa tgatttctgc 3349081 gttttcctta cagtcgataa tgtaccagca ttccgtcttg ccgagttctc cctcttcgtt 3349141 ttctccggca tagtaatcat cagggtgaac tttaattgac gtatcttcct tcacatccag 3349201 cagctttgtc agaagcggaa accgatcccc ctctacgccg ccgaatactt cacggtgctc 3349261 ttcccaaagc tcgatcaatg tctttccttt atacgggcca tttgcaacag tgctcggtcc 3349321 ttttggatga gcggaaatgg cccagcattc ccccgttgat tctgaaggaa tactgtatcc 3349381 aaatctatct cgtaaagcgg ttccgcccca gattttttct ttaaacacag gcgttagaaa 3349441 aatcggtgat tgcgtcatga tccgtacccc tcccctgtaa ataactgatc atcattttcc 3349501 cggtgcgccc ctcttacaaa cgcccgtata agctgccttt ttcctatgac aacatatgta 3349561 caaagcatca tcttttcatt accccttcaa agaaaacgct tcctatctat tatatcacgt 3349621 cgaaaagaag ctttgtttca gccttttcct cgataagaat aattctcctt ttttgataca 3349681 aattaataaa aaccgtcaat atgtttaaga aggagagaaa ctatgcaaat cgactctgat 3349741 ctccagaaca atttagacac actgaaaaaa acattgggac aaaacgacga tatgatgttt 3349801 tatacatttg ctttcggaga tagcagacaa aaggcgtgtt tactgtatat tgacggtctg 3349861 acagagaata aaatgctggc gcaatacgtc atttctcctt tacaaaaaga ggcgttggcc 3349921 cataaggaat gctcgattga agacttatcc gccttttttt tcggctttca ccacagcgtt 3349981 gtttctacaa tgaaagaaat agagcagctc gttttttcag ggcaagccat tttgctcgct 3350041 gatggctatc gcggaggatt agctttcgac acaaagtcag tcgcaacacg cagtcttgat 3350101 gaaccctcct ccgaagtcgt ggaacgcggc cctaaaatag gatttattga aaagctgcgg 3350161 acaaacacgg cgcttttgcg tgaacggacg agtgatccta atctcgtcat caaagaaatg 3350221 acactcggaa aaaggaccaa aaagaaaatc gctgtcgctt atattcagga tatcgcccca 3350281 gattatgtcg tcaaagaagt gtttaaaagg ctgaaatcag tcaatataga taatttgccg 3350341 gaatcgggga cgcttgaaca gctgattgaa gacgaaccat tttcaatttt ccccacaata 3350401 ttaagcacag aacgaccgga ccgggtcgaa agttctctat tagaagggcg agtgtccata 3350461 ttagtggatg gtacgccgtt tgctttgatt gtaccggcta cggttgacga atttattcat 3350521 tcgcccgatg attacagcca gcgctggatc ccaatgtcac ttgtacgcct tcttcgttat 3350581 tccagcatcc tgatcaccat ttatttgccc ggtctgtata tttctctcgt ttcttttcac 3350641 accgggctat tgccgactag aatggccatt tccattgcag gcagcaggct taacgtacca 3350701 ttcccgcctt ttgtagaggc ctttatcatg atctttacga tcgaattgat tcgagaagcc 3350761 ggattaaggc tgcctaagcc gattggacag acaattggcc ttatcggcgg cgttgtcatc 3350821 ggacaggcag ctgttcaggc gcaaattgtc agtgcgctta tggtcattgt cgtttctgtc 3350881 acagcactgg catcctttac cgttccttca tacgcctata actttccgct gcggatcatt 3350941 cggatcgggg ttatgataag tgcaacagcg cttggcatgt acggcgttat aatggtttat 3351001 ctgtttgtga tcggccatct catgcgcctg aaaagctttg gccaggatta cattatcccg 3351061 atcatggcgc agcctggaca ggatttgaaa gacacagtca tccgtattcc cacgatgttt 3351121 ttaaaaagaa gaccgacacg aaacgatccc gaagataaca tcagacaaag gtgatggcta 3351181 tgaggaaatc agagcataaa ctgacattta tgcagacgct cattatgatc agcagcacat 3351241 tgattggtgc cggggtgctg acccttcccc gctcagccgc cgaaaccggc agtccgagcg 3351301 gatggctaat gatactgctc cagggcgtta tttttattat catcgttctg ctttttttgc 3351361 cttttcttca aaaaaacagc ggaaaaactc tttttaagct caacagcatt gtagctggaa 3351421 aattcatcgg ctttctattg aatttatata tctgtctata tttcattggg attgtttgct 3351481 ttcaagctcg gattttggga gaggttgtcg gattcttttt gttgaaaaat acgccaatgg 3351541 cagttgtggt gtttatattt cttgcagttg ccatctatca tgtaggcgga ggcgtttatt 3351601 caattgcaaa agtatacgct tatatttttc ctataaccct tattattttt atgatgcttc 3351661 tgatgttcag ctttcgcttg ttccagcttg attttatccg gccggtattt gaaggaggct 3351721 atcaaagctt tttctcttta ttcccaaaaa cattattata tttctccgga tttgaaatca 3351781 ttttttacct ggtccccttt atgagagatc caaagcaagt gaaaaaggct gttgctctgg 3351841 gcatcgcgac ttccacattg ttctacagca ttactttgct cattgtgatt ggctgtatga 3351901 ctgtggctga ggcaaaaacg gtgacatggc cgaccatttc ccttattcac gcattagagg 3351961 ttccgggtat ttttattgaa cgatttgatt tgttcttaca gctgacctgg acagcccagc 3352021 aatttgcctg tatgctcgga tcctttaaag gcgcccatat cgggttaacg gaaatctttc 3352081 atctaaaaaa taaaaacaat gcatggctgc tgactgcaat gctggctgcg acgtttttca 3352141 taacgatgta tcccaaggac ttgaatgacg tgttttatta cgggacgctt cttggatatg 3352201 ctttcttaat tgtgattaca attccattct tcgtctggtt tttaagctgg atacagaaaa 3352261 aaatagggag ggggcagctg caatgaaaac agcatcaaaa ttctccgtca tgttttttat 3352321 gctgctggcc ctctgcggct gctgggatgt caaagatatc gagcaactat ccttcgccag 3352381 agggctggcg atcgatgaga caaatgatca ccagtacaaa ctgacgtatc aaaatcttct 3352441 tccccaaagc gaagacagcc aagcatccgg aaaacccgaa tttgttaatg taacgtccca 3352501 cgggaaaacg attctggaag cagtcagtga tgtatccatc aaggaccctc ctgtttatag 3352561 cgatcattta aaagtgatcc ttctgggaga aaaactgatg aggaatcaaa atgtagacca 3352621 agtcctcaac cactttatcc gggatgatga gctgcggcga agcagctatt tgatggcagc 3352681 cagagggaat gcagctgatg ttttcacaaa aggaaacccc aatcagcagc agccgatgcc 3352741 ctccgaaaaa ctgattgatt tgacaactca cagcggatat aacggtaaga ttatgatacc 3352801 gctgcgcatc ggaagagctt ctgtctactc tcagaacggg tacagttatc ttattcaagc 3352861 cgtgaaaaac gaaaagggaa aagccaagta tgacggagca ggcattatca aaaggggcag 3352921 caataaactc gttgggtttc tttcagctga tgaaacccaa acactgtcat gggtcatggg 3352981 gacgatccaa ggcggtgtca tgccgacgac agataaagga catccgatta cgtttgaaat 3353041 taaaaagtcg aaaacgaaaa ttaagcccgt cattgaaaac ggaaagcctg tctttcatat 3353101 ttctgttaaa acgaagggca tcctgacaga agaccaaaac ccgaatgaaa actcctttag 3353161 caaaagttat ttgcacaggc tggaaaacat ttttgaaaaa aagcttgaac gagatgtaaa 3353221 gcaggtgatg gataaactgc agcacgagta taaaaccgat ccggtctttt tatcagacca 3353281 cataaggatt caacaccctg actactggaa taaagtaaaa gggcattggg atgaaatatt 3353341 ttctgagact gattttaagt acgatatttc ttttaaaatc attaactttg gcacggtggg 3353401 aaagtaagca atcaaaaggg tgcgcatgat cgcgcaccct tttttatgtt ccgacagtct 3353461 gctgttttcc ggccgctcct ccctgtccgt ttttgtcccg taaatcctgc tcaatttctt 3353521 caaggcttct tccctttgtc tctgtcactt taaatcggac aaataagaac gccatgatac 3353581 cgatcgcggc ataaatcagg aataaataac tgattccgat cgcttccatt aatattggat 3353641 aggttaatga aacaatcagt gtcccaacgt gcaacattaa ggtcgaaaca ccggtcccga 3353701 ttcctctgac gtgaagcggg aacaattcag gaagcatcac ccacacaacc ggtccccagc 3353761 tgaccgcaaa gacaacgata aacacgccta aacaaatgac ggtcgtccat gaggcagccg 3353821 gagtgttatc gaaaaagaga tttactaaag cgagaacgat caagctgatc accatgcccg 3353881 cattcccgaa tagcagtaac ggctttcttc caatcttgtc gatgatttta atcgctacta 3353941 atgtcatgag aacattgact gtgccgattc cgaccgtgcc taaaatcgaa gcggagtttc 3354001 cgaatccgac gtttgtaaag gtctttggcg catagtagat gatcgtattc gttccgataa 3354061 attgctgcaa aaaagcgagt cccaaacctg caataagcgc tgggcgcacc catggatcga 3354121 acagctcctt cagaccgcct tcatcctgct tttccgcttc ttttatatca tgtatttcct 3354181 gatcaatatc ttttgtgcca cgcaattttt caagaatttt cttcgctttg ctttcttcgc 3354241 cattcgtgaa cagccagcgc gggctctccg gcataaacaa aatgccaata agcaagagca 3354301 atgacggcac agcagccaat ccaagcatcc agcgccacgc ttcggcatcg gcaaatatgt 3354361 aattgacaat gtaagaaaga aggatgccga ccgtgatcat cagctgattc agtgatgaca 3354421 gcgccccgcg tttatgtttt ggcgccagtt cagataaata aaggggtacg attgtcgtcg 3354481 atgttccgac tgcaagtccc aaaatgatgc gaaacagcac catgactcct gtatttgggg 3354541 ccagtgccac accaagaccg cctatacaaa acagcagcgc ggctgccata attgcttttt 3354601 ttcttccgaa acggtcagtc agcttgccgg ccgctcctga gcccaatatc gccccaacca 3354661 gcaaggagct gacaacaaga ccttctgtaa acgcgtttaa gcctaactcc tttttcataa 3354721 ataaaatagc tccggaaatc actccggtat catagccata taacgcgcct ccaagagctc 3354781 cgaaaaaata aagccatata tttgactgct ttttcataaa gatgactccc tttctccatc 3354841 agctgcaatg acattgtctg tgggattttt ttagaaatct tttagcctct ttttccggcc 3354901 attaaacctt tttatttttc tgatcataag ttttccaatc atttacttgt atttttttca 3354961 atgtcgccga aacattttac ctgctgcggc gtccaatata aggtgattca gtacattatc 3355021 gttatcaatt ttcaaaaaca agaacttata aatataggaa tatttatcga aaaatgtctt 3355081 tcgagtagtt gccccatggc aaatagaatg gtacgcttca aatattaaag aaacgtgagg 3355141 tattgatata tggaagaacg atcacagcgc agaaagaaaa aaagaaaact aaaaaaatgg 3355201 gtgaaagttg ttgccggatt aatggctttt ttagtcattg cggcaggctc tgtcggcgcc 3355261 tatgcttttg taaagctgaa caatgcttct aaggaagctc atgtcagcct tgcacgcgga 3355321 gaacaatctg taaaacggat caaagaattt gatcctggaa aagattcttt ttctgtattg 3355381 ctcttaggaa ttgatgccag ggagaaaaac ggcgagaccg tcgatcaggc aagaagtgac 3355441 gcgaatgtgc tggttacatt taatcggaaa gaaaaaacag ctaaaatgct gagcattccg 3355501 cgtgacgcct atgtaaacat cccaggccac gggtatgata aattcacaca tgctcacgct 3355561 tacggcggcg ttgacttaac tgtgaaaaca gttgaagaaa tgctggatat tccagtcgat 3355621 tatgtcgtag aaagcaattt cacggctttt gaagacgtcg taaacgagtt aaatggcgtc 3355681 aaagtaactg taaaaagcga taaagtcatt cagcaaatca aaaaagatac aaaaggtaaa 3355741 gtcgttcttc aaaaaggaac acatacgctt gatggggaag aagcgctcgc ttacgtaaga 3355801 acacgtaaag cggacagtga ccttttacgc gggcaaagac aaatggaagt gctgagcgcc 3355861 attatagata aatcaaaatc attgagctca attccggctt atgatgatat tgtggatacg 3355921 atggggcaaa atttaaaaat gaacttatct cttaaagatg ccatcggcct gttcccgttc 3355981 atcacttcat tgaaatcagt tgagtctatt cagctgacgg gttatgatta tgaacctgcc 3356041 ggagtctatt atttcaaatt gaatcagcaa aagctgcagg aagttaaaaa agagctgcaa 3356101 aacgatttag gtgtataatg aacgggatgg cgattacgcc atcccgtttt acatatttcc 3356161 ttgttgaaaa ttatcaaagt aacgtttagc cttaatttat atggattatg tttcacaggc 3356221 aagctgaaca tactacacga agcagcttca tttttaagga ggttccccta catatgaaat 3356281 gtattgcgat tgatctagac ggaacattac tgaataaaga aagcgtcatt tctgcggaaa 3356341 acagagaggc gatcaagcgg gccgttgatg ccggcatcct cgtcaccatt tgcacgggaa 3356401 gagcgacatt tgatgtaaaa gcgctgctgg atgacttgga catccctatc attgcagcta 3356461 atggcggtac gatccacgac acgggttacc gtttgatcag ccggacatta atggatcagg 3356521 aagccggtaa agcgattgct gattacttac tttcaaaaaa catttacttt gaggtatata 3356581 cagatgacca tctgctttct ccttttgacg gcgaagctaa gctgcacgcg gagcttgaca 3356641 ttctaaagag cgcaaaccca aacgagcaga cggatgactt gtggcaagga gccatgactc 3356701 aattcaaaca gtttggcatt aaaccaatcc ctcatatcga atcggttttt gacggcggtg 3356761 aaaacattta taagcttctt tgcttctcct ttgatatgga caagctgaaa caagcgaagg 3356821 aagaactgaa gcatcataaa aaactggcgc aaacctcttc aggaaaacat attatcgaaa 3356881 tcctgccggc ctcgtcagga aaaggacgcg cgttaacaaa gctggctgac atatacggaa 3356941 ttgaaacaca ggatatctat gcgatcggcg atagtccaaa cgatttgtcc atgtttgaag 3357001 tcgccggaca ccgtatcgcc atggaaaatg cgattgatga attaaaagaa aaaagcacct 3357061 ttgtcacaaa aagcaatgac gaaaatggtg tggcctactt tatagaccag cttctttcgg 3357121 ggcaatatgc ataaagaaaa gactccagag attggagtct ttttctttta ttgcacccgt 3357181 atacttcctg cgtatttatc cttccaatat gtgctcgtgt tcatattggt aatggtcacg 3357241 ccgtttgata atgtgacatg aacaacttgt ccgtttccga tatagatgga gggatttaag 3357301 cttgttgatt gaaagaacac aatgtctccc ggcttcaggt ccgccttctc aatcttagtt 3357361 ccggcattgt actggcttgt tgcgtatcga ggcagggaaa taccggctgc tttctggtat 3357421 acatattgga caaatccagc tgtatcaaat cccgtctcag gtgttactcc gccctgtttg 3357481 taaggcactt ctccgacata aagcgtcgct tcggaaacaa tcggattttc tttcgggatt 3357541 gtcaggttgt caaatcggcg aatacccgtc atcttcgatt tccagtaatc ctctgacaaa 3357601 taggaaatgg ttactttttc tgaccggctt gcctgaatga acctgcctgc gcccgcataa 3357661 atgcctgcat gtgaaattcc cgttttatac gtattgctga aatagacgac atcaccaggc 3357721 tttatgttct gaggggctac cttctcgccc actgcccact gctgttcggc tgatcgcggt 3357781 agataaatgc cgagtgcctg ttgaaacaca tattgcacaa gccccgagca atcaaagccc 3357841 tctgacggcg tgcttccgcc aaacacatat gggacaccga tatatttttc ggcctcctga 3357901 acgacaggaa catcagccgt tgccggatcg gcagcgattc gtctcgcccc gatataagtt 3357961 ccgctccaat agctgctttt tttgtaattg gtgatgataa ccccttttga ctgtgtactg 3358021 tgaaccattt ggccgtctcc gatataaagg gcgtcatgtg tcggaacagt gccggtgctt 3358081 ccctctttct tgaaaaacaa aatatcaccc ggcttcaggt tttccggttt tacagctgtt 3358141 ccgattttat actggtcgtt tacagatctc ggcagatgaa tatcagcctt actgaacaca 3358201 tattgtatca atcctgatgg atcgaaaccc tctttcggcg tttccccgcc atatttatac 3358261 tgatatccaa gcaggttttt tgcttcgctg acaatcaatt ctgatgatgt atcagcttcc 3358321 gcaatctccg cttttgtcat aattggaacc aaaaaacaaa tgataaccgc cacaagcaaa 3358381 aacttcttcc agtttgccag tgtgttcact tttattatct cctcctcttt ttgcagtttt 3358441 aacatcggta tttttttgaa tatgttaaga gactttttaa tatttttaca gaatgaatat 3358501 gctgggcaaa taaaaagaga gtgtctcatc agacactctc ttttttgaat tatttattgg 3358561 cgtttaccgg ttcttcctgc tgctggattt tattcatttc catatcaatc ttctgttttt 3358621 cctgatctgt cagctgatca ttgaatttaa aagctgacat aaacatgaac acgatggcta 3358681 cggcaacaaa cggccagatg gctttgacaa atttcatctt tatcactccg attatttaga 3358741 ttttagtttg tcactatgat caatatcaaa cgtcagtttt ccgtcttcta ctttccaagc 3358801 gaaattagag tctttcgtca gttcgcgaat aatggttttc tgtttaaggc tgtctttttt 3358861 cacaggcgca ggtgtcgctt catggatatc gatcggtgtc acttcaaagc gtcctgttcc 3358921 atttttcttc aggtgatact gaaccagtgc actgtctctt gttctcgtcc agccttggtc 3358981 aaagacaaag ttgccgaggc tgtagaaaat gacggttccg ttatatactt caatcggttc 3359041 taagacgtgc gggtgatggc cgacgatgat gtcagctccc gcatcagaca tggctcttgc 3359101 aagctggcgc tggcggtcat ttggatcatt gtcatactct tgtccccagt gtgactgcac 3359161 aacaacaatg tccgcatgtt ttttcgcttc tgaaatcata gggatgaaga tttcaggatc 3359221 tgcgggcagc acgcccggcg tattcttttt agccgcgaaa cctttcccgg acacatcggt 3359281 aaagccaagc gtcgcaatcg ttaccccgtt gactttctgg tacgaaattt tctttttcgc 3359341 atcacttaag ctgtatcccg ctccaacgat atcaagattt tgcttcgcaa attctccaag 3359401 cgtatctttc atgccctgaa cgccgtaatc cattgcgtgg ttgttggcgc tgttgagaac 3359461 cgtgaaattc atatccttca agactttcac tgattcctta ttcgtctgca gatgaatctc 3359521 tttatctgct tgtttataat tcttttgata ggttaccggg ttttcaaagt ttcctgctac 3359581 ataatccgag gctctaaaga tcggttcaac atattgaaaa atactgtctg cccctttttg 3359641 ctccgttact ttttcaacat agcgtcccat cataatatcg cctacaaatg aggctgagag 3359701 tacgtcgtca gaatacgttt tgaccttcgg cgtttccgct tttcccgccc acatgaaagc 3359761 gaacataagg acaaaaacga tcggaatggc aataaatacg tgcttattgg ttttcttttt 3359821 ttgctgtttt gtcagcttta gcagcttttc atgaaagctc agttcttttt tcatcgtttg 3359881 acacacctta cattaaatta agtagtaaac aaacatgata gcaaaggtcg ctccgctcaa 3359941 tagcagcgtg cttccgaacg taatggttaa accttgtttc tgaatggtat tggcaattaa 3360001 acctggcacg atgatgccga ttcctcgaaa ttctgcgatt tcaaatggta caatcgggta 3360061 tagaaaatca aacgcgattt ttaggacgat ccctgttatc agcatggcag cgaattttct 3360121 gcgtccgtac aaaatcataa atttggataa accgtatttc acaatgacat acgtgagcaa 3360181 gctcactagc aaaacaagta aaataaagac cggctgatta aacacaagtc ctaaatatcc 3360241 cggtacaaca agtcctgccg gcacgatccc tgttttttcc gcaaaaatta aactgagtag 3360301 tacacctaaa attagtgcga tgtataaatc tgatccgaac atgtctgcat ttccccctag 3360361 cttacgagct gctttacctt gtattcgtgg attttttcaa ttaaaggctc tgcggcacca 3360421 tgaatattgc cgacgccata tatgacacgg ttgtgcattc ttttctttaa caattccata 3360481 atttcatctg ttgacttata ctctagatca tgcagtttgt ctgcaggaat tttgccttct 3360541 tcgtaggctt ttacgatcgg ttctgttgtt tcaccgatta agatcagttc acttgcttca 3360601 atataaggca atacgtcatt tgcgaattgc tgtgtccgat cgacacggtc tgcgcggcag 3360661 ttcatgatga tgatcggatc atcggtcggg taaccgattt cttttacacg tttccatata 3360721 ttcaaagtag aagaagcgtc gtttgcggca aacccattaa caaagtgccc aggctcgctc 3360781 ggactgatca gcggaagaat tctcattgct cccggatctg gcggcgcatt cagcattccc 3360841 ttaaatgctg tttcttcgtc aatgccgagt gcttgagcca cacccagcgc cagagaagcg 3360901 ttatcaggga ataccatgta ttcaaattta cgtaaatact catctgtaat ttttgagtta 3360961 tcagcaatga tgacttttgt gtttcgttct tttgcttttt gtttaaagaa ctcggtatat 3361021 tcactatctg taatgacaag atggccatta taaggaattg tagcagtaaa cgcttctgca 3361081 atttcatcaa gcgtcggccc catgacatcc atatggtctt ccaaaacatt cacaatgacg 3361141 ccgatattgg cctgcagaag ttcttcctga aagatgattt gataatctgg gttaacagcc 3361201 atgcattcac tgacaatcgc gttagcccct ctttctactg tttctctcat gacttctttt 3361261 tgctctccga tattcggccc ctgaggtttc cgtttaatcg gcttttcctc cggtgtgtcc 3361321 cagtaaatca ttcttgcatc tgttcctgtt gtttttccaa cagtcttgta accggcttct 3361381 attaatattc cggttgtcag ccttgtcaca gtcgattttc cgcggatgcc gttaatattc 3361441 acccgaacag ggagggcatc aatgtttttc tgatgtcgtc gtttttctaa tattccgatg 3361501 accagtatga cagcacaggc tataatgagt aaccacattg cttttcgaca tctccttcta 3361561 tattgttgta aattcattca tcagtatata gaatcactat gaattctcaa tcggcattat 3361621 gtaacataat cttccctaat cgactaagcc aaacttctct tttgaaagag attttatacc 3361681 tacaaactgt tttctatttt tggaaaacag caggacttat accttatcac tttttaaaaa 3361741 aatcaaagag aatgcgcttt catttttctc ctgatatcct tctggacgta tagtcacacc 3361801 ctgctgtttg tatttaatat gcatttcaaa tcaatctttt tttcagcctt tgttatcaag 3361861 catttcctgc tatcatgcgt gtttccggtt cttatgaaca caaaataatt ttatcctgtt 3361921 tcttaaggac aaggtcataa tgtcatcctt tctgcatgga ataagcaata tgaggcccat 3361981 tccaaaatga ctaaggaggt tcgagatgaa aacgctaaac atacgagtcc gaattctcta 3362041 acataattaa acattttctg ggatgatagt cttttctgtt tctccccatt tacaggtcta 3362101 aacgcatgac tttgaaacaa ttttaataaa acttaatatt tgttcaagaa atcttcatcc 3362161 atatttgtga agactttgtc aaaaaaagag tgaaaacctt aaatttttca attatatata 3362221 caatttacaa ttagatttct tttgatattt ttattgctaa cttcggattg ttcatgataa 3362281 tctatctatg taaacggtta cataaacaag gaggagctgt tttggctaca attaaagatg 3362341 tcgccggagc ggcgggcgtt tcagttgcga cggtttcccg caacctgaat gataacggct 3362401 atgtacacga agaaacgcga acgcgtgtca tagcggcgat ggcgaagctg aactattacc 3362461 cgaatgaagt cgccagatct ctatataaaa gagaatcccg actgatcgga cttttgctcc 3362521 cggatatcac aaaccctttc ttcccccagc ttgcccgcgg tgcggaggat gaattgaacc 3362581 gggaaggcta tcgccttatt ttcggcaaca gtgacgagga attgaaaaaa gaacttgaat 3362641 accttcaaac ctttaagcaa aatcatgtcg caggcattat tgccgcaacg aattacccgg 3362701 atctcgagga atacagcggc atgaattatc cagttgtttt tctggacaga acgcttgaag 3362761 gggctccttc tgtgtccagt gacggctata caggagtaaa gttagccgcc caggctatca 3362821 ttcacggaaa aagccagcgc attacgctct tgagaggacc cgctcacctg ccgaccgctc 3362881 aagaccgatt taacggcgct ttggaaatct taaagcaggc tgaagttgat tttcaggtca 3362941 ttgagacagc ttcattttca attaaagatg cacaatcgat ggcgaaggag ctgtttgcct 3363001 cttatccagc gacagatggt gtgatcgcga gtaatgatat tcaagccgct gccgttttac 3363061 atgaagcatt gcggcgcgga aaaaacgtgc cggaggacat tcaaattatc ggctatgatg 3363121 acattccgca aagcggactt ctgttcccgc cactttctac aattaaacag cccgcatatg 3363181 atatggggaa agaagctgcc aaactgcttt tgggtatcat taaaaaacag ccgctggcag 3363241 aaacggcaat tcaaatgcct gtcacctata taggaagaaa gacgacaaga aaggaagatt 3363301 aagatgcgta atatttgtgt gattggtagc tgttctatgg atttagtggt cacctcggac 3363361 aaacgcccaa aagccggtga aacggttctt ggcacgtcat ttcagactgt gccgggcggc 3363421 aaaggagcaa atcaggccgt tgccgcagcc agacttgggg cgcaagtgtt tatggtcggc 3363481 aaagttggag acgatcatta tggaacagct attttgaata atctcaaagc taacggcgtt 3363541 cgcactgatt atatggaacc ggttacacat acggaaagcg gaaccgctca tattgtgctt 3363601 gctgaaggcg acaacagcat tgtcgttgtc aaaggcgcga acgatgacat caccccagcg 3363661 tatgcgttaa acgcgctcga acagattgaa aaggtcgata tggtgctgat tcagcaggaa 3363721 atcccagaag aaacggttga tgaggtgtgc aaatactgcc attctcacga tatcccgatc 3363781 atactaaacc cagcaccggc ccgcccgctc aagcaggaaa caattgatca cgctacctat 3363841 ctgacgccga atgaacacga ggcttcgatt ttattccctg agcttaccat ttccgaagct 3363901 ctggcgcttt atccggcaaa gctctttatt acggaaggaa aacaaggcgt ccgctattcg 3363961 gctggcagca aagaggtgct catcccgtcc ttccctgtag aacccgttga tacaaccgga 3364021 gccggtgata cgtttaacgc agcatttgcc gtggccctgg ctgagggaaa agacattgaa 3364081 gccgcattgc ggtttgccaa tcgtgccgct tccctttctg tctgctcctt cggtgcccaa 3364141 ggcggaatgc cgacaagaaa tgaagtagag gagctgctgt catgaaaaaa cacggtatac 3364201 tgaacagcca tcttgccaag attttagccg accttggcca cactgataaa attgtcatcg 3364261 cggatgccgg actgccggtt cctgacggcg ttttgaaaat tgatctttca ctgaagccgg 3364321 gccttccggc tttccaagat acagcggcag tactggctga ggaaatggcg gtcgaaaaag 3364381 tcattgctgc agctgaaata aaagcatcca atcaggagaa tgcgaaattt ctagaaaatc 3364441 ttttctctga acaagagatt gaataccttt ctcacgagga gtttaagctg ctgacaaaag 3364501 atgcaaaggc agtcataaga acaggagaat tcacaccata tgccaactgc atcctgcagg 3364561 caggtgtact tttctagaaa ggaagatgaa acatgcagat tgaaatgaaa gacattcata 3364621 aaacattcgg aaaaaatcag gtgctgtcag gcgtttcctt tcagctcatg cctggcgagg 3364681 ttcacgcatt aatgggagaa aacggcgccg gcaagtccac gcttatgaac attttgacag 3364741 gcctgcacaa agcagataaa ggtcaaatca gcataaacgg aaacgaaacg tatttttcca 3364801 atccgaaaga agcggaacag catggaatag cctttatcca tcaggaattg aatatctggc 3364861 cggaaatgac cgttcttgag aatctattta tcggtaaaga gatatcctcc aagctgggcg 3364921 ttttacaaac aagaaaaatg aaagcgctag caaaagagca atttgacaaa ctttccgtct 3364981 ctctttctct tgatcaagaa gccggcgaat gttccgtcgg acagcagcaa atgatcgaaa 3365041 ttgcaaaagc gcttatgaca aatgccgagg taatcattat ggatgaaccg accgcagcgt 3365101 tgactgaacg tgaaatcagc aagctctttg aggtcattac agcgttaaaa aagaacggcg 3365161 tctccattgt ctatatttcg catcgcatgg aagaaatttt tgcgatttgc gacagaatta 3365221 ccatcatgcg tgacggaaaa acggtagata caacaaacat ctcagaaact gattttgatg 3365281 aagtcgtcaa aaaaatggtc ggacgggagc tgactgaacg atatccaaaa cgcactcctt 3365341 ctctcggtga caaagtattc gaggtgaaaa atgcttccgt aaaagggagt tttgaggacg 3365401 tcagctttta tgtgcgttcc ggtgagatcg tcggtgtttc aggattaatg ggagccggcc 3365461 ggacagaaat gatgagagcg ctgttcggcg ttgacaggct ggacacgggt gagatatgga 3365521 tcgctgggaa aaaaacggct attaagaacc cgcaggaagc cgtgaaaaaa ggtctcggct 3365581 ttattacaga gaatcgcaag gatgaagggc tcctgctcga cacctcgatc cgcgaaaata 3365641 ttgccctgcc caatctgtcc agcttctcac caaagggtct cattgatcat aagcgggagg 3365701 ctgaatttgt cgatctgtta atcaagcgcc tcactatcaa aacagcatca ccggaaacgc 3365761 acgcacgcca tttatcagga ggaaaccagc aaaaagtggt gatagccaag tggatcggca 3365821 tcggaccgaa agtgcttatc ttggatgagc caaccagagg tgtggatgtt ggcgccaaac 3365881 gagagattta tacgctgatg aatgagctga ccgaacgcgg tgtcgctatc atcatggtgt 3365941 catcagagct tcctgaaatt ctgggaatga gcgatcggat tatcgttgtc catgaaggca 3366001 gaatcagcgg cgaaatccat gcgcgagaag caacacaaga acgaattatg acacttgcca 3366061 cgggagggcg gtaatatgaa aacggaacaa ctgcaaacag aacaaaaacg gattcacttc 3366121 gacggagtca tgcaaaaact cggcccgttt cttggtttat ttattctcgt tatcattgta 3366181 tctattttaa atcccagctt tcttgaaccg ctgaatattt taaacctgct tcgccaggtc 3366241 gccattaacg gattaatcgc gttcgggatg acctttgtta ttttgacagg cggcattgat 3366301 ctttctgttg gcgctattct tgccctgtcc agtgctttag ttgcggggat gattgtgtcc 3366361 ggtgtcgatc cggttctcgc gatcatcctt ggctgtatca ttggtgccgt actaggcatg 3366421 atcaacggat tattgattac taaaggaaaa atggcgccct ttatcgccac gcttgcgacc 3366481 atgactgtgt ttcgcggact gacgctagtg tatacagatg gaaatccgat taccggactt 3366541 ggcacaaact acggttttca gatgttcgga cgcggttact ttttaggcat tcctgtaccg 3366601 gcaattacga tggttcttgc ctttgtcatc ctttgggtgc ttcttcataa aacaccattc 3366661 ggacgccgaa cgtacgctat cggcggcaac gaaaaagccg cgctcatttc aggcatcaaa 3366721 gtgacgcgcg tgaaagtgat gatctattct ttagccgggc ttttatccgc tcttgcaggt 3366781 gccatattga cttcccgcct gcattcggcc cagccgactg cgggagaatc gtacgaactt 3366841 gatgctatcg cggcagtcgt cttaggaggg acaagtcttt ccggcggccg aggacgcatt 3366901 gtcggcacgt taatcggggt gctgatcatc ggcacactta ataacggact taatctgctt 3366961 ggcgtctcat cattttatca gctggttgtc aaagggattg ttatcttaat tgcggtattg 3367021 ttagaccgca agaagtcagc ttaggagggt tttacatgaa aaaggctgta tccgtcattt 3367081 taacgttatc attatttttg ttaaccgcct gttcgcttga gcctccccaa tgggcaaagc 3367141 catcaaactc ggggaacaaa aaggaattca ccattggctt gtccgtctca acgcttaata 3367201 atcctttttt tgtctcatta aaaaagggta tcgaaaaaga agctaaaaaa cggggaatga 3367261 aagtcatcat tgttgatgca caaaatgatt catcgaaaca gacgagtgac gtggaagatt 3367321 taattcagca aggtgttgat gcattattaa tcaacccgac tgattcttcg gcgatctcaa 3367381 cggcagtaga atctgcaaac gcagtcggtg tgcccgtcgt aacaatcgat cgatctgcgg 3367441 aacaaggaaa agttgaaacc ctcgttgctt ccgataatgt aaaaggcggt gaaatggccg 3367501 cggcgtttat tgccgacaaa cttggaaaag gagcaaaggt ggcagagctt gaaggcgtcc 3367561 ccggcgcatc tgccacacgg gaacgcggct caggattcca taacatcgca gaccaaaagc 3367621 tccaagttgt cacaaaacaa tcagctgact ttgaccgcac gaaaggcctg actgtcatgg 3367681 aaaacctgct gcagggacat cctgatatcc aagctgtttt tgctcacaac gatgaaatgg 3367741 cgctcggtgc tctcgaggca attaacagct cggggaaaga catattggtg atcggttttg 3367801 acggcaataa agatgcgctc gcttccatta aagacagaaa gctgtcagcc accgtcgctc 3367861 agcagcctga attaatcggt aaattggcta cagaagcagc agatgatatt ttgcacggga 3367921 aaaaagtgca aaaaacaata tccgcgcctc tcaaactaga aacacaaaaa taattgtctg 3367981 atgtttagga acctgcgata acgtgaatag agatatagaa tgaattattt ctcttacgtg 3368041 aggagaggaa cggcatgaac aaaccaacaa aactattttc aacattagca cttgcggctg 3368101 gaatgactgc ggcggctgct ggcggcgctg gcacgatcca tgctcaacag ccagaaacaa 3368161 cggtaagcat tgatgattta tacagttatc cgattgattc ttatttggta tcagcagagg 3368221 ctctaaatgt cagaacgaag ccttccgcat caagccagaa agccgatacg ctgcacttag 3368281 gagatagcct aaagctgatt tccttctcaa atgctgactg ggcaaaggtt aagtataaaa 3368341 atggaaaaac aggatttgta tccactcatt acattgttaa agcagcgaca acggtaaaaa 3368401 ccaaaacaaa aacaaaagtg tatacatccg ctgacggaaa gagcattaag actcttccag 3368461 cagacacaag cgtttctttt ttaggctgga gtaaaacgaa taaaggcggt tttgattttg 3368521 attgggtatt cgttgattac ggcggtacga caggttatat gaaaacaaag gatttacaca 3368581 tgacaaaata actgagaggg attccgcata aatgcggaat cccttttatt atgaattgat 3368641 ttgtcacatt cccaagatat ttctcaggaa atattgtcgt atgctgtgtc gaaaccttac 3368701 atgatcatcg acatttttgt tcacgctaaa aagcggaggt gtaaatatgg atcaatttga 3368761 agcagcatat gaatcgtata aagcccggca aacaactgcc gatcaagaaa atgttccatc 3368821 tggaaaagaa gaaattattg cggttagaag aaatgaggaa gacaatatta tcgcagtgaa 3368881 aaccaataca ggaagagagc tcgactaccc tactgcgctg tcagaagcaa aatcaggaaa 3368941 actcgctcat gttgatgtct tccataaata cgggcgtgac attttgcgaa gtgaaccgga 3369001 cggcatcaag gaaaataacc tgtctgagct gccggatttt taaacaaata cagccctgcc 3369061 gtatgttgga cagggctgta ttttaaacaa aaggctgctg gatgtattcg gctaaccgtt 3369121 ttgcactgtg agaaatatcc tctgcagctg cataattcac gccatagaac acatatggag 3369181 gcagatactt catgccgatc agattactcg tggcctgaaa tggtttcaat agctcactga 3369241 tcgagtaatg atttgctccg cccgcttgat atttttccgc ttcgctccct gttgatacag 3369301 ccagcatcag ctccttgcca tgcaaggcat ttccttctga accaaaagcc cagccataag 3369361 tcagcacaag atcctgccat tttttcaaga gcggcggaga gctgtaccaa tatagcggga 3369421 attgaaagac aatccgatcg tattcctcgc acagctgctg ttccttcgca acatctatcg 3369481 cttcatccgg gtattcctta taaagatccc gtactgtgat attgtcatgt ttactcaatt 3369541 cctcagccca cgccttatta acaactgagg tctccatatg aggatgcact gccaaaacca 3369601 atattttcat cagaccacac ctttactgtt ttgatgttat tttatctaaa atcaggaaaa 3369661 gagccaaata aaaagaaagc cctgctaaaa ggggctttct ttttttcttt tattcagggc 3369721 ttccttcagt tgtttcgata tctttcgcaa aatcagggtt atccagattc gcattaaaga 3369781 aatccgctgt gttcggaagt ctgagattca tgttcatttt ttgagaaatc gtaaccgtgc 3369841 aatcctcaag cacatagtca aaaacgtgtc cgcctgaatt gcgtccttcg tcaatgaagt 3369901 gcaggtgata gccagaaacg gcgattccgt ttgcataagc tggtgtcaag aaacctacaa 3369961 tcgttcctct cacgttgtcg aagttgaaaa tcggctgtgt tttgaccgct tcaaccattg 3370021 gcacgtaagg tttttcttga agttctactg ttcttgtctg caccttttta aacaatccgt 3370081 caatgcgaat tgcataaaat aagtttctgc ttggcagcat gctgttgatc tctttttcaa 3370141 agtcttcgcg tgtcattttc gcatcaattt tgtgcgtcat gtccggtgta aagaacgtaa 3370201 atgaacagaa cggtgaacgg tctccatttt ggaccggtgt cgcggttccg tctgagcgaa 3370261 gacggtaaaa ttcgccgtca aacccaatca gctctccgtc aagcttgtta aaggttccga 3370321 taccgaagtc tccatatttc ggaatctctg acagttcaaa atctccgtca tatactccgt 3370381 ctaatagaga agtcattgtt gatacttgat aaatctggct cacaggctga tctttttgac 3370441 cacggctgag cacttgaatg ttgctttctc gtttcatatt tcccttcact ccttttattt 3370501 agtgctgttc ataaaacagt gtcgtgatgc gcagagtgct agagagcttt cgttttcatg 3370561 agttccccga attctttcgg aagcttgtca cttgctaaat taatgttatc actgtagtca 3370621 accgggacat cgatgatgac aggaccttca gcgttcatgc cttgacgcag aacatctgcc 3370681 agctggtctg gtgattctac gcgcaagcca gttgctccga agctttccgc atatttcacg 3370741 atatcgatat ttccgaaatc gaccgcagat gtacggttat attttttcaa ttgctggaat 3370801 gcaaccatgt catatgtgct gtcgttccat acaatgtgta caattggtgc ttttagtcga 3370861 actgctgtct ctaattccat tgctgagaat aagaaaccgc cgtcaccaga gacagaaacc 3370921 actttttctc ccggtttcac caatgaagcg ccgattgccc aaggaagcgc aacgccgagt 3370981 gtttgcatac cgttactgat cattaatgtt aacggctcgt agctgcggaa ataacgtgac 3371041 atccaaatgg cgtgcgaacc gatatcgcaa gttactgtaa catgatcatc gactgcatta 3371101 cgcaactctt taacgatttc aagagggtgc gctctgtctg atttccaatc tgcaggcacc 3371161 tgctcacctt catgcatata ttgttttaaa tcagaaagga ttttctgctc acgctctgca 3371221 aattccactt tcacagcatc gtgttcgata tgattgatcg tggacggaat gtcaccgatc 3371281 aattcaagat caggctggta agcatgatca atgtcagcga taatctcgtc taaatggata 3371341 attgtccggt ctccattgat attccagaat ttcggatcat attcaatcgg gtcatagccg 3371401 atcgtcagaa caacatctgc ctgctctagc agtaaatcgc caggctggtt gcggaacaaa 3371461 ccgatacggc caaaatattg atcctctaaa tctctagaaa gggtaccggc agcttgatat 3371521 gtttcaacaa atggaagctg aacctttttc aaaagcttgc gaaccgcttt aattgcttcc 3371581 ggtcttccgc ctttcatgcc gaccaaaacg acaggaagtt ttgctgtttg gatttttgct 3371641 atggccgcac tgattgcatc atctgctgca ggaccgagtt ttggcgctgc aacagcacgc 3371701 acgtttttcg tatttgtgac ttcattcaca acatcttgcg gaaagctcac aaaagcggcc 3371761 ccagcctgcc ctgctgacgc tatcctaaat gcatttgtaa cagcttccgg tatatttttt 3371821 acatcttgaa cttctacact gtattttgta atcggctgga atagcgccgc attatccaaa 3371881 gattgatgtg tccgttttaa acgatctgca cggatcacgt ttccagcaag cgcaacgaca 3371941 gggtctcctt cagtgttcgc tgtcagcagg cctgttgcca agttagaggc acccggtcct 3372001 gatgtgacta acacgactcc cggttttcca gttaaacggc cgactgcttg ggccatgaat 3372061 gctgcgtttt gttcgtgccg ggcaacgata atttcaggtc ctttatcttg taaagcgtca 3372121 aataccgcat caatttttgc acctggaatg ccaaatacat gtgtgacacc ttgctccact 3372181 aagcaatcaa caacaagctc cgcccctctg tttttcacaa gggatttttg ttcttttgtt 3372241 gcttttgtca acaccctcac tccttattat gcattttaaa cgtaaaattt taaatatctt 3372301 gtgataagtt tcactataca ctctttggaa attgacctcc aatatcgatt cgccttatga 3372361 ttaatatgta atacgaatta ttaacctatg gaaaggaatg catattgaat ggagcttcgc 3372421 catcttcaat actttatcgc agtagccgaa gagcttcatt tcggaaaggc tgcccggcgg 3372481 ctgaacatga cgcagcctcc tctcagccag cagatcaaac agctggagga agaagtcgga 3372541 gttacgcttc tgaaaaggac aaaacgattt gtcgagctta ccgcagcagg agaaatcttt 3372601 ttaaatcatt gccgcatggc attgatgcaa atcggacaag gaattgaact ggcacagcgg 3372661 acggcccgcg gcgagcaagg ccttctcgta atcggttttg tcggatcagc tacatatgaa 3372721 tttctgccgc cgattgtccg ggaatatcgt aaaaaattcc catctgtgaa aatagaactg 3372781 cgtgaaatat cctcgtctag gcagcaggag gagctactaa agggcaacat tgatattggt 3372841 atacttcatc ctcccttaca gcatacagct ttacatatcg aaaccgccca aagcagccct 3372901 tgtgttttag ctttgcctaa gcaacaccca ttgacttcta aggaatcaat tacgattgag 3372961 gatttaagag atgaaccaat tattactgtt gctaaagaag catggcctac tctatacatg 3373021 gattttattc agttctgtga acaagcgggc ttcagaccca acattgtcca ggaagccaca 3373081 gaatatcaaa tggtgattgg tttagtcagt gccggaattg gtatgacatt tgttccttcc 3373141 tcggccaaaa aattatttaa tttggatgtt acttatcgaa aaatggacca aatacagctt 3373201 aatgcagaat gggttatcgc ttaccgcaaa gacaatcata atccgcttat aaagcatttt 3373261 attcatattt caaattgtca gcagacaaga actaaagaga gtgatgcagg tacatgaaca 3373321 atacttgcaa tctctttttt cttttgggat tcttatggaa tttttattaa tttaatataa 3373381 tcgcttagta caactttata tcagtatacg tatacataca gtacaaatag ttggcaagga 3373441 catcagtaag cgcaggacat tagtttgatt ttaaaaatga aagatagaga ggtgaagtaa 3373501 attattgagt tcaccggcat attcacattg ctcgcttttt tcgtaacaat gatttttatt 3373561 ttctggagac caaaaggact aaatgaagct atccccgcca catttggcgc tttaatggtt 3373621 ttattgtgcg gaagtgtgtc attggcagac ttaggggaaa tcggaacaaa agtcacgggt 3373681 gcatcggtta caatccttgc cactatgatt atggccattg cactagaaag ctttggtttc 3373741 ttttattggg tggctgcaaa actgctccaa caatccaagg gttcaggcat caagcttttt 3373801 tggctaacca atttgctctg ctttctcatg accattttcc ttaataatga tgggagcatt 3373861 ttgatcacaa ctccaatcct tttgcttgta ctaaaatatt taggtttaaa aaaacatcaa 3373921 aaagccccat atttattaag cggtgtttta atagccacag cctctagcgc accgattggc 3373981 gtaagtaata ttgttaattt aatttctctc aaaatcattg gaatggatct atatcttcac 3374041 accgccatga tgtttgtccc tagtatgatg ggactcattt ttatgacttg tctactgttt 3374101 atgttctttt ataaacgtct tcccaaaagc ctgccagata taccgggcca ttttcagtct 3374161 ctgcggcata gaaggtacca tcctcttcat tcgccatcag ctcctttacc agaacgaaat 3374221 caaacaaaaa tcatgttgtt tgtgcttgca tttgtttttc tcgtcagaat gagtctattt 3374281 gcagcatcat ataccggtat ttctgttcct ctagtcgctg tcatcggatc ttttatcctg 3374341 ttgagctgga gatggattta tttcaaaacc tccccaagag acttgttata taaatcgcct 3374401 tggcacattt ttatattcgc ttttactatg tatgtcttaa tttatggtct gcataatatt 3374461 ggattcacag agttacttgt gagttatttt gaacctgtgg tttctggaag cctcgcccat 3374521 gcaactttcg catcaggtat ctctacttca gttttttcta atctctttaa caaccatcca 3374581 gcgttaatga tcagtacttt taccttaact gaaatgaccc tgaatccttc aacaacaaaa 3374641 atcatctact tggcaaatat tatcggcagt gatatcggtt cattattatt acctatggga 3374701 accttagcaa cgcttatttg gatgcatata ttaaaacagc atgatgaaag tatttcatgg 3374761 ggcgaatata taaaaacgac cattatcatc attccgctga ctgttctttt tacgttaaca 3374821 tgtttatatt tttggatcag ttggttattt ctttagcaca gtatgaaacg aaaaactgcc 3374881 ttctgctttt caagagggca gttttgtata cactagggaa gatgcattgt ctttagatga 3374941 tttaacttcc aaatgactgg ctctccactt gcgttaataa gctcaatgat attattagag 3375001 acacccttta atagtccgac tttttctggc acctctccca tatcaaatat gaccaattca 3375061 ccaatatttt ttttgatctg ctcctcaaaa ttacgcacaa gaggaacttt ggaaggcacg 3375121 accggcaatt gtgagttgtc aagagtatac ggtgtttgtt cagttgaata aggggtaaac 3375181 cattttaaat gatgcataga tataaaaagt attttaaata cgggtgagaa aaatacaata 3375241 taatcgttta aaacatttgt aacatatcca tggatcgatc gacccccagt tacataaact 3375301 tcaataaact ggcctttgac cttgtttaat gtatttctat atgaaaaagc ttgagtttct 3375361 gcctctatca ttggatcttc cggattgatc aaaaatggct tctcagtact ggtcactatt 3375421 ttcgccttgt ttatttgatg aagatgcaac aagggaatat aaagataatt gcagccatca 3375481 aaaataacaa aaatatcctg tccgatatct atgagggtgc cgacaaacct tgtatctcct 3375541 gaaatgacaa cctcaacatc tgtgttaagg aattgattca aacctttcac gattctcctc 3375601 ctttaactga aaaagggcat cactttatct gatgctcctc cattatctat taaaatttac 3375661 gtttccagtg atagtctatc gttctgacaa tcgtttcata gctataatct tccttttgtt 3375721 ttcctgaact ttttattgaa cttgaatagc ctggtgatct tgatgattga taatctgaag 3375781 atcttggtga tcgtttagat gattttgatg attgataatc tgaagatttt aatgatcgtt 3375841 tagatgattt tgaagaactt tttgaacgtg acgaacggcc agatttggat gattgataat 3375901 ccgaagattt tagtgatcgt ttagatgatt ttgaagaact ttttgaacgt gacgaacgac 3375961 cagatttgga tgattgatca tctgaagatt ttagtgatcg tttagatgat tttgatgagc 3376021 tatatgattt tgaagaaatg aacgaattgc tgtccttatc attattgtct tcctggtttt 3376081 gttcattttt ttgatcctct tttttgtacg acccttttgg acctaagctg atgcttttta 3376141 tgtgaaaagg atagatgcga agcacctctt gatttttcac tatagtataa tggccgtcgg 3376201 cattatctac aaggataccc tcaatggctt ccggacctcc acgattaatt gaaacccatt 3376261 tatgagtcag actcttaaaa acctcgctta aatcatcagc ttccaaaact ccaactggcg 3376321 tctgctcttc tattttcaaa tcaggctcgt gtttacttat acttttgatg tgatggatat 3376381 taaaatacac taccccatcc tcatttgtgt ttaacgcagc gtaatcatct cccagccaga 3376441 ccaatcttcc ttttttagat tccggacccc cttggttaaa ttgaactgat tggtttatta 3376501 aatgtccgat taagctatga aaatcatcag catcgagcat ttcctcagtc tcaattgttg 3376561 tggtgctatt attggtatcc tcagtaatac ttttcacatg ctccaactga taataaatta 3376621 tttttttttc agcttgtaaa gctatataat ctgattttac agctgttaat tttccttttt 3376681 tagattccgg acctccacga tatacagtaa caattttatc tttcattgag tgcaaaaagt 3376741 tataatacga tatttcatta tttgaatgat atttcattct cctcttgctc attcaaattc 3376801 ctcctagtca cttatacata gatgataaac atactgcata tatacgtgtc acatttattt 3376861 gttgaactaa ttcaatagcc taattgtcgc tttttccgcg aatacccatt ttcacgcatt 3376921 cataaaatac ttaaatgatc tttgaggtat tgtgaacggt ttttaatata ctcgcagatc 3376981 acatccggct cacggtcaaa acgctcaata tcattctttt tatacgggtc catgaggaca 3377041 aacggcctaa tccgttcata catcgccatg attttcggtt ccatatattc tattgtaaaa 3377101 agagattgga gcgttttttc taacaggcgc ttgtaggact tgcgaaactc ggattcatcc 3377161 aatatccggg cggttagtgt attaaatcct tgaattctta cataatcggc agccatccgc 3377221 tctccatgga tatccctgcc ccaagtcgca tcataatccc aaggaatcac ctcaaataat 3377281 ccggtttccc cgcttctgta taatgcgtag ttgtggacaa acccgtcata gttcgaggtg 3377341 aatacaatac cagcaagcca gcgcaaatac ttatcgacat ccacgtgttt tgtcacttct 3377401 gacttaaact gagctttagg gaccgtatta attttaaaaa tcatatcttg taaataaaaa 3377461 tcatcttcct cagtccctgt tttcttttca tatccaagct ccagcgatgt tttcgtttcc 3377521 ctttctaaat cgctcatcag agaaaagttg gcatcatcat ccaccgcata aaaaatcgcg 3377581 ccatcagcca gcttcctttt cgccaaataa tattcatcta cggattcaag ttcaagataa 3377641 accccttcat tcttcccatt catctttaca aacgcaaact ctgcctttgg agacagtgtc 3377701 cctagctccg agaaaaaatc cagagacaat ttgtttctca tcaaggaagg gtctttatac 3377761 tccgcattta agtgaatctc tcgcgcgccg cggaatgttt tcggctgata aaaggaaata 3377821 tggtatgact tctttttgaa gtctctgata tgtgatcccc gataagcgat atcaatatcc 3377881 agcctttttt gatttacctt catcacagct ggcaccggat catcgtccca tatatccttt 3377941 tttaattcac gcaagtcttt tggatgaaca aacagctgat aaagcggtaa attggattga 3378001 ttcttcatcc ataatcctcc ttacaaattt taggctttta tttttataag atctcagcgg 3378061 aacacttata cactttttaa aaccgcgcgt actatgaggg tagtaaggat cttcatcctt 3378121 aacatatttt taaaaggagg atttcaaatt gggccactat tcccattctg acatcgaaga 3378181 agcggtgaaa tccgcaaaaa aagaaggttt aaaggattat ttataccaag agcctcatgg 3378241 aaaaaaacgc agtcataaaa agtcgcaccg cactcacaaa aaatctcgca gccataaaaa 3378301 atcatactgc tctcacaaaa aatctcgcag tcacaaaaaa tcattctgtt ctcacaaaaa 3378361 atctcgcagc cacaaaaaat catactgctc tcacaagaaa tctcgcagcc acaaaaaatc 3378421 gtaccgttct cacaaaaaat ctcgcagcta taaaaaatct taccgttctt acaaaaaatc 3378481 tcgtagctat aaaaaatctt gccgttctta caaaaaatct cgcagctaca aaaagtctta 3378541 ctgttctcac aagaaaaaat ctcgcagcta taagaagtca tgccgcacac acaaaaaatc 3378601 ttatcgttcc cataagaaat actacaaaaa accgcaccac cactgcgacg actacaaaag 3378661 acacgatgat tatgacagca aaaaagaata ctggaaagac ggcaattgct gggtagtcaa 3378721 aaagaaatac aaataatcta agttttcatt gtttcaatag gctgccggcg gaggtacgga 3378781 agcctatttt tttatttgcc ctgtattaga tatatgtcat gacataacat atgcaacccg 3378841 catcatttgg tttcctttaa accatttcgt tataatcaag gtatcctaac gataaaggcg 3378901 gttgttgcta tgtacatatt tcaagctgat cagcttagtg ccaaagacac atacaagcta 3378961 ttgtcaggta ccgttattcc ccgccccatt gcatttgtga caacactttc ttcaggagga 3379021 gcggtaaatg ccgcgccttt cagtttttat aacgtcgtca gctcagatcc tccgcttctc 3379081 agtatttctg ttaacaggac ggaaggacgc caaaaagata cagcacgaaa cgcagtggag 3379141 aacggagaat ttgtcgttca tgtcagtgat gaagccatca ttgaagatat caatgaaaca 3379201 gctgcaagct taaggccgga tgaaagcgag cttacacgca cctcgcttca tcctgttgaa 3379261 agcaaagctg tttcagttcc cggcattaag gaagcccgcg ttcgctttga gtgcaaatta 3379321 gagcggcata ttacctttga caatgatcaa ggcatcacta cagcagatct gctcatcgga 3379381 agagttgtct gcttccacct agatgaaaag gtgtatgatg cagaaaaggg atatatttta 3379441 acggatgaat taaagcctgc ctcacgattg gcgggaaatc actatgccaa gctgggggaa 3379501 gaattcacac tgattcgtcc cagctgaaga gaaggactat ttaaatagaa gaaactagtc 3379561 aaaaagacct tatgattaca aaatatcgcc tgtaaataac tgaaaaaata tcaaaaaaaa 3379621 gaacacccag agcaagctcg gggtgttctt ttatgaaacg tttttccttt ttcttcgtat 3379681 aaaggtagat taggaggaat tggaatgaca aacttttgga ttttaatgct gatcgctatt 3379741 accatcagtc tcgcctctca attttttata aagaaaaaat acggtattga taaatccggc 3379801 tggcgatata agcatgtcag caatacacac aaatggatcg aaatcacttt acttattttg 3379861 tttgtgtttt cactctcctt ttttccagtt gaatatttgc ttcttttatt ttttattgtg 3379921 attgactcaa tacgtatttt tatggagtgg cattatagac ctgaagataa acagtatatg 3379981 taccacattg tagaggtctc ccttatgttt atgcttttga tttatgtttg taccctatag 3380041 ttatttaaat ccccacagcc gctccgtctc cccgaggatc ggctccgcct tggagaaagc 3380101 cttcttcatc aactttgatt gcagccgctt gtcccatcag cggatcatag tcaccgacaa 3380161 cctccacgag atgcccgctg tctttcagtt tttggattgt tttgtctgtg aatctgccct 3380221 cgactctgag accttcgtat tcctctcccc acgttctgcc ccatacccag cgcggttcgc 3380281 tgattgcctg ctgtggatgc attccgtagt ccagcattcg ggtaatgatg gccgtctggg 3380341 tctgcggctg gccttcgccg ccttgtgtgc cgtacagaat ttttggcttt ccgcctttac 3380401 agaccatagc cggcatcaac gtatggaagg tgcgctttct cggttcaagc gtgttgacat 3380461 gattttcatc cagtgagaaa aacgatccgc ggttttgcag taatatgcct gtatcaccgg 3380521 cagtgactgc cgagccaaat tcaaagtaca ggctttgaat gaatgacact gcgttgccat 3380581 ccgcatcgat tacggccgca tatgccgtat cacttcccac cggcctgctt tctgccggta 3380641 ttgcgagata gccgatttct tctgccaatt gttttgcata acgtttgtcc aaaagccttt 3380701 caagcggaat gtctgcaaac gccggatcag tcaggacggc atcccgatct agaaaactct 3380761 ttttcaatgc ctccacaagc acgtgataat actcaaatga accgtgttcg atttgggtga 3380821 aatcatagtt ttccaaaatg ttcagtgtta ataaaccggt aaatccctga gaattcggcg 3380881 gcgcctgata cacactgtat cctcgataat cacttgatac aggcgctgcc cactcacccc 3380941 gatgcgcttt aaaatcatcg attgtcatgt aactgccgtt attctgtaaa tgtgagacaa 3381001 tccgctgagc gagatctcct tcataaaatg cgcttcttcc tttttcagca atcaagttca 3381061 gactgtctgc aagctctttt tgcacaaacc gctctcccgg gacaggtgct ttgccccttc 3381121 tcgtgaagat gtcagccgtg taaggcgtgg aagccagcag ttcaatattc ttttctgtgt 3381181 gacgacactg atcagctgat acaggaaacc cattttgggc ataatcgcgt gcgggctcca 3381241 atacatctgc aagagacaga cgcccgtact ccttcaggac cgcatcccag ctatcaacca 3381301 ttcccggcac ggtaatagca ctgtcaattc cccgcagcgg aatcgcgctt tttcccttat 3381361 atacatctct cgttacgttt tttcctgaac ggccgctgcc attgtagact tttactgcct 3381421 ttgtttcctg gtgaaaggtc agccaaaagg aatccccgcc aagtccggtc atatgcgggt 3381481 acacaaccgc aagacaagca ctcaccgcaa cagcggcgtc aaacgcgttg cctcccttat 3381541 ccagtatgcg gtttccggct tgagaagcga gataatgcgg actgacgacc atttgctttg 3381601 taccgatgac agatttgttc atcacaagtc ccctttttta agaaattttc ttcagtatag 3381661 ggagcctgat ttttcacatc tactgatccg gcagaaaaac tgacgaactt tcttcttttc 3381721 gcaaataata agatattttc gcattcattt cgaaaacaaa tgaaaaatta ttatttctat 3381781 acgtaacttt tatgataaaa tgattgctaa aaggctacga aagcaggtgg agcaattgag 3381841 tcatgaatat caaatcccca accttgtact tgatgagact gataaacaaa ttctcacgat 3381901 tttgcatgaa gaaggcagaa tttcttatac ggatcttggc aaaagagtcg atttgtcacg 3381961 ggtcgccgtt caggcccgta tcaaccaatt aattgaagcc ggtgttattg aaaaattcac 3382021 cgctgtcatc aatcccgcta aaatcggcat ccatgtttcc gtgtttttca atgtcgaggt 3382081 agaaccgcaa tttttagaag aggtcgctct taagcttgag gaagagcctg cggtcaccag 3382141 cctttatcac atgacaggcc cgagcaagct gcatatgcat gggatcttta ccaacgatca 3382201 agaaatggaa gaattcttaa caaaacggct gtatccattg cgaggcgtcg tcagtgttga 3382261 ttgccagatg ctgatcaaac gatacaaaag ccgtatggga atgaagctgt aaaggagaga 3382321 aacaaatgaa aaaccatcct tatcgggata tgacggccgc aatggttcgc accggcatat 3382381 tagggttcgg cggcggacct tccgtgattc cgctgatccg ccatgaagcg gtcaataaat 3382441 ataaatggat tgacgatgat gaattcggag aaatattagc aatcgctaat gcgcttcccg 3382501 gaccgattgc caccaaaatg gctgcttatc tgggctttaa gctaaaaggc acattaggtg 3382561 caattgtggc gatcctcgcc cacattctgc ctacatgtct tgcgatggtg ggcttgtttg 3382621 cggctgtaaa tgtgttaagc cattcagcaa ttgttgcagg tatgattggt gccgtcacgc 3382681 cggtaattgc ggtcatgctc ggaatcatgg cgtacgagtt tggccaaaaa gcgcttaaag 3382741 gtttcggctg ggttaccggc atcctgtttt ttatcatcgc ttttatcggc ctgcaaactt 3382801 tacagattaa tcccggcctg gtcattatca ttttcttagc ttacggggcg tttcatttta 3382861 aactgaaaga caaaatcaca aataaacatt caaaagataa aggaatgtca gcctcatgat 3382921 atcgatctat ttatttatgg cgttttttat cgcaaaccta ctgggatatg gcggcggacc 3382981 tgcgtctatc ccgctaatgt ttgaagaagt cgtaaacaga tacagctggc tctcaaacga 3383041 tcaattctca aatatgctcg cacttgcgaa cgcattgccg ggcccgatcg ccacgaaaat 3383101 cgctgcgtat gtcggctaca gcgcaggcgg gtggcccggc ttcctaattg ccctgatcgc 3383161 aaccgtcgta ccgtcggcgc tcgcattgat cgtcctgctg cgcatcatcc agcgcttccg 3383221 ccaatcacct gtcatcaaag gcatgacgct gtccgtccag cctgtcatcg cggtcatgat 3383281 gctcattctt acctggcaaa tcggcgcaga cggcatcaaa gcgatcggct gggtccaatc 3383341 gatcgtgatt acgggaattt cgctccttgc catgacaaaa ttcaaaatgc atccggcatt 3383401 tttgattatt gcggcgtttt tatatggggg ccttgtgatc ccttatttat agaaaaaagc 3383461 acctggacag gtgctttttt attttagccc agaaatgccg tttgatatga cagctgtttc 3383521 ttctcctgcg tcactcttga tcatgtgctt gacttgcagc gtggttcctg ccattctcac 3383581 agattgcttc aactgggacg aattggtttc aacttgtatc caaacaggag gctggacctt 3383641 ccaaaataaa tagagtgcaa gaatcagcaa gccagcaatg accgacagca aaaacttcat 3383701 atcgcatcgc ttcttttcag taagcggctc gcagcggaca gcgcctgatg atcacgaaga 3383761 atatcgcctg gacgattgcc ttctcccagc acatagcctt taaaggacat tcccataaaa 3383821 tgaaaaatat gttcgaattg ctgaatcagc ggcagccctt ttatttttgg attgtctccg 3383881 cccactgcta ttacatatgc ctgtttcact gacatttgct gtttaaaatc aggaaatctc 3383941 ggatctctca acgtctgtga ccagcgatca ataaacagct ttaatgtccc tgacatgcca 3384001 aaccaataaa ttggggtggc gaatataaga atatggcact gcaatatccg ttcaatgata 3384061 gaatcgtagt catcttgaac aggacgaaag ccgccttggg cgtgacgcag atcttcaatt 3384121 ggttgaattg gatatttctg caaataaatg tgctccgcat cgaatccttg aacagccttc 3384181 tccgcaagaa catccgtatt tccgccagac cgagttccgc cgttaataac cgcaattttc 3384241 atgatgcatc tgctcctttg tttacgaatg attttcttca tcatataatg gattcatcaa 3384301 tcaatacaga tgattatttc gattaatcca atcgctaaaa ccgatttaga aaggaagaga 3384361 acaagtggaa ttgaagcagc tgatcacctt tattacggcg gctgaacatg taaacttcac 3384421 cctaaccgcc aaaatgctta attatgcaca atcaagcgtt acctctcaga tcaaatcact 3384481 tgaagaagaa atcggaacgc ctttatttga acggctcggc aagcggctta tcttgacaga 3384541 agcaggaaaa acgttcaaat cttatgcaca gaagatcatt gcgttaacag aagaagcgaa 3384601 aatggccaca aatcaagtaa gagaaacaac cggaacctta aaaatcgggg cgacggaaag 3384661 ccagtgcaca taccgcctgc cccctatcat aaaagaattt aaacaggctt ttccccaagt 3384721 aaagctcata ttcaaaccat atatctccaa tgaacaagcg aaagaacagc tcttacaggg 3384781 ccagcttgat atcaccttca tcttggatgt aaaccggatg gaagacgcac tgcacgttga 3384841 atctttgatt caggatgaga tcaaaatggt ggctgctaat gaccatcctt ttcctgcgga 3384901 tttaccagta acattgaagg atcttcaaaa cgaaactctt ctgctgacag aggacggctg 3384961 ctcgtaccgc acgctctttg agaacaattt gcatgactcc ggtatctatc ctaacaaatt 3385021 ggaattcgtc agcatagaag ccatcaaaca atgcgtgatg gccggacttg ggattggaat 3385081 cttgcctgaa atgacagtaa aagatgatat tgcagcaggc cggatgaaag aactcaattg 3385141 gcagagcgat tgccccgttt tcactcaatt agcatggcat aaggacaagt ggatgtctgc 3385201 gccattaaag gcttttatcg atttgacacg gaaaacattc aaataaaacc tctccacaag 3385261 gacgacaagg tttttgagac cagggcacac acatacaaaa aaaacacttg atgacttaga 3385321 gccccaagtg ttacacgtga tttttctgat aaaacgttcg caaaacatgc gtctcaaggt 3385381 cagccaggcg gacagggatc ggcagcctgc tttcttgatt gatcaagctc atcgtgatct 3385441 gatagctgct gtctaaatca atataattac cgcaagacaa gaaaataggc ttcacgtccc 3385501 gccgcgttcg cagcgcccgt ccatatacct cgccgtcaat gataatatcg gtgtatgcgc 3385561 ctacttcaat ttcaggcgtc acgaaatcgc agcctttgat tttgagatag gttttcgcta 3385621 tcccaatcgt cggcttgccc agaaaaaaag ccgcatgggt ggcaacgccc atatgattgt 3385681 aatgcagata tccgttgcca tcaaacaaga agacatccgg ctccgtctcc agctttttcg 3385741 ccgcctcgat gatcaagggc agctcgcgaa acgcaagaaa accggaaaca tacggcacgc 3385801 tgattctccc catgctgtgc actttttcaa tgacttcttt tgtatcagcg tcaattacga 3385861 taatacagca cactccgtat ggttctccat cctgctccca ataggccagg tcgacgcctg 3385921 cgcaggtgtt gatggagtct ggatggatcg tgggggatag gttgatacga tttttaaggt 3385981 taaattgcac ttgtaaaaag tcttgttcct ttttcatatc aaatttatgc acatcaaata 3386041 ccttcataac gattgctcac tctcgaccta aattaatgtg agtctctctt ctcgattcta 3386101 gtatttcaaa atgaggacta tctgtatcta tctcgtactt atttaataga ttgccttctt 3386161 catcccaatt cttttcagaa attagtatgg aatgctcata ctgttgctca ctttttttcc 3386221 tgccattttc aaaccaaatt atgcttatac cgtgcaattg cccatatcgg tattcttttt 3386281 cacttttttt attcccgttt tcataaaatt cacatgttaa accatgggcc agaccattct 3386341 tatatttagt aaaatagatg atttgaccat ttggatataa ttcgtaagcc agccctgtaa 3386401 acggctggcc attttcgtct tcaggattat ctaaaatctc atcacttacc gaagagaacc 3386461 ataaatcctc aaagtccact cccttttctt ttatactctt catatcatat tcattttcca 3386521 tactttaaag cctccggtat ataatttgta ttttgagtta tatattcaca atgtggacat 3386581 ctaggcattg ggacaccttc tggcatcttt ttatttattt tcctagcact tactacatat 3386641 accattaaat cttttaaatc cgcatcaggt ctttgaagta acgcttcatt tagagcatta 3386701 acttcggcat gagaacccgc ccctgacgtc tttatataac cttctttaag ttctgtaggc 3386761 atatttacaa ttctatcatg aataagtgga tgtagtacct taggtggctt cccatctata 3386821 ttgtttattc caaaataata attgcctgtt tttttgtcca atacaccagc taccgcaggg 3386881 cctctttgtt ttttagttag accagaagat ttaattctac taagttcgtt tagtacttct 3386941 gcccttagat ttattcgatg gtgaagatct tctttagaca atacaccatg cttatttctt 3387001 aaatattgaa gcctagtttg tttttcttca gtagtcttag caatattgct aataaggctt 3387061 tcattactca ctttattgac atatggagca tttttttggt acaaccgatc aaagtagtgt 3387121 gccaatcctg ctccaccaat aatagtaata gcttccagcg ccccttgctt ccgcttctcc 3387181 tcagacactt tgtttccgaa catatcccgg cctgtgacag cttctgagaa tccgtttgac 3387241 gcaacaaggc cgtatgcgcc catttctgtc attttgagaa tgtctaagga tttgcctgtt 3387301 ttgtaggcgt ctaatgcgtg ttcagcagcg atagctgctt ttccggtttt gtagatggct 3387361 tttccgcctt tgaaggcccg gcctgcccag ccgacgactg gtatgaatcc ggcagcggcc 3387421 atagctcctg ctgtcacacg ctccgcggtg gagagttttt ctccggtaac cggatcaacg 3387481 ccttcggttg ctcttttata atcataatag ccagtgactt ctccagtaaa gttgcaaact 3387541 ccatcccatg ttttttcgta ccacggtttg tttgcttctt cctcggcttt ttcctggagc 3387601 cgtcttgctt ctgcttgctg ggtttttgca tcgatatagg ttgttccttg attttctact 3387661 tcaatgacgc ttttgtagac ttcattgctg tggaaggctt ttttgtcata gtacataggg 3387721 gatgcgctct tcccattgct ggtggcctgc atgagaacag aatatttggt gagcactgcg 3387781 ttgtccagag attctaaatt ttgatattca gtggtcaggg attcatcaag cttatcgaca 3387841 gctgtgattg tatcacgtct gattttttgg gcatcgccca tcttatctgc atagtcgtca 3387901 agcgtgtaca tgtcgagatc aataatatcg ctgatgcctg acaaaataga atcgatttct 3387961 tctttatgag cggagacaat ctctgaggct ttcaggtctc cattgggcag ctcatgatcc 3388021 aaaaaagaag tttccacata tgaatcattc agttcttgat ctttaatatc tcctgaaatg 3388081 ccgtttaaaa acgcaatttg agcagagaca agcgtcagcc agctgtctac gatttctgcc 3388141 tgtccctgaa aaaaatcttt aatattgtcc gcgccatttc ctttaaaatt atcgcctaaa 3388201 tcggcaactc cctgaaacgc ttttttcagc gtattcagct gctcttcaag cgtctcatat 3388261 tgcttttttc tgctcttcgc ttcttcgatt aaagattttg attcaaatac tttactcatc 3388321 gcactgccct ttctgttcta ttttaccgct atcgcctcgt cctgctcttt gagtgaatct 3388381 acgttatcct ttgtatcctc gatatttttc tgtaccgctt ttttgtaatc tccgagcatg 3388441 gttttgatgt tctcctcacg ctcatggtat tttttcgtat aatcgaggct gttttttccg 3388501 ttggatcctg cggcgccgat tgatacgtca gcaagcgcat ctttgacaga atctaatgtt 3388561 ttgatgactg tgtcgtactt cagcttaatt tctgacataa aaaaagatca ccaccatttt 3388621 agtttactaa ttgtatttcc gacttcttcc gcgaactctt ctcccttttt aagaagatct 3388681 gctgcaccat ttgctatgaa caattccgat gcatatttag ctttatccca ttcaagatca 3388741 aaaattttcc cgttaatcga agccatatac tcgttatatt tatcattcac aatcttagat 3388801 gcttccgatt tcgcctcttc tcttcccttg tcgaaatcat cggcttttgt tcccgtccaa 3388861 tgcttgccca attccggttt cacaatttct ttgatttcag tgattgcctc ttcttgcagt 3388921 gtgtctatgt ccttttttgc ttttttcagc ttttcgatct tgtcttccac gtctgaaatt 3388981 tttccgttga gcgaactttt gatatccgct agcatacttt cataacccat ctgaatcacc 3389041 tcttaatact caaaaagtcg tatggagggg ctgatgaaga tagacttttc catactttat 3389101 ttccatatat tatattttaa aatagccaga aggcggctta aatagggtaa atggcttaat 3389161 ttaggcatat aacgctcttg aaatgtaggt atttgatctt gtttttgttc gttatacagc 3389221 taataaaagc gttttataaa atgaaatcac ctaatgtcat agttataaag gcacttgaaa 3389281 gaggcagatg ttgttgatct gcctctttcg gcgctgagct tattgttcat gtttatgttc 3389341 ttcatctggt cggccatgtc tgattttgtc atttggcttc tattattccc cccttctgac 3389401 cctttggatc aaaagcttgt attagctgca gtcccagttg tacagaacgt ttgaaaagtc 3389461 ttttttcctt agatcttcag gtgtgatgaa aaaattggcg atgccgacgt ctccccacat 3389521 tgaatcgata tcatcgtctg aatcaatttg taacagcatg atggtgtgtt ctttatatgc 3389581 gtattcccgg ggatcatgct gggtaaaaga agcgtatccg ccaattttat ggccaaatcc 3389641 gttttcagcc agttcattat aaatgtcttc ttcatcctcg ccgaactgac caaagaactc 3389701 cattgtttcc atgcccgtat actgctcaaa ttgaaaatct gtaggcagca cccattccga 3389761 agatttcaca ggctcgactg ccgcttctga taaaatcgga aaatcacatt cgcctgtgcc 3389821 aataaatgaa aaatcagaaa caagctcgtc atcgttttct acgatatttt caaaatagat 3389881 cactctgaaa ttcttttgtt cacatcgatc gtcaaaattc aatccataga cgtcatcatg 3389941 aacagaaatg tagaactgca ggatacctga agaagggtag ccgtcaagct ggggaatgtg 3390001 cgagaaatta atctgcgcca gaagtttcat cggctgtcca ttttcgtcag tcggatatgt 3390061 ttcatgcttg gggaaatagg gatcaccggc aattttgctg tcatatcgtc ctgttttccc 3390121 ctttctcaca ttcagtttca cgtattcttt cgctgatttc tccagcaagt cgcggtacgg 3390181 tctcattttt tcgggcagat gattcatcag attctctcct tttccggcat ctccaaggtt 3390241 ttattttctg gttttcttct aatgtttttc aaacgaatgt ttaaagaagc cctacttctg 3390301 cataattttc caaacaatag ttaaatagta gcaaatgtat tcagcacccc gcaatagatg 3390361 aaaaaaagac tggtgcgcaa ccagcctttc tttttcatct attgaattgc acctgacgga 3390421 acaaccgcct tccgtccgac agaataatac tccactcctg cagccaaagc ctcatccaat 3390481 gtgtagcagt ttctgccgtc aaatatgagc ggcgtttcca tcaaatcctg ataagccgct 3390541 aacgggaatt gtttaatgtc agcccagtcg gttaaaatca tgacggcgtc agaccctttg 3390601 acagcttcct cgatcgtctc tttatattca acagcttgcg ggagaacatg ctttgcatgg 3390661 ctaactgcaa tgggatcgta ggctctgata cgggcgtcga gcgcagcgag acggtctgca 3390721 ataacaattg acggcgcttc tctcatatcg tcggtattcg gtttaaatga caggcctaaa 3390781 agggcaatcg tttttcccgt caccccaccg agcctgttca gcgctttatc aaccagcatc 3390841 gcctgctgat tgttgttgac tttgataacg gatttcagca gttcaaaatc atgctcgaca 3390901 ttgccggcaa tttgcacgag ggcgtttgtg tcctttggaa aacaagagcc gccgtagcct 3390961 atgcccgctt ttaaaaactg gctcccgatc cgcttatcct gtcccatccc gtatgcgact 3391021 gcttcaatat cggcgccgac cttttcacat atattcgaaa tttcgtttat aaaactgatc 3391081 ttagtggcca gaaaagcatt tgaggcatat ttgatcatct cggcgcttct gatatccgtt 3391141 tggtaaatcg ggatttgaaa cggacggaag agctcctcca gcgtatttgc tgttttctca 3391201 tcggccgtcc cgatcacgat cctgtcacca tgaaaggtat catagatcgc cgacccctca 3391261 cgcaaaaatt ccggattgga tgcgaccgaa atactgacag gctccgctag atgttcagta 3391321 atcagtccat taatcaaatc gtttgtccca acgggcactg tgcttttcgt taccacgact 3391381 gtatctcgtt tgacatgctt tgcgatgcgt ttggccgcat ctgtaatttg ctccagattg 3391441 gcgtgcccgt cgcttttctg cggtgtgccg accgctataa aaatgatgtc tgcctgtgcc 3391501 aagcctttct catagctcgt ttcaaagttc agccgtccat cagctgtatt ttttctcatc 3391561 agctcttcaa gacctggttc aaatatgggg gaaatgccct ttctcatttc atcaatcttg 3391621 tgagcgtcaa tatcaatgca ggttacatga tgtccaatct cagaaagaga aacacctgtc 3391681 acaagaccga catagcctgt tccgatgact gttatattca ttgtttccct ccaacagtta 3391741 aattgctgct ttgcagcttc cgtaatatcg tatgagaaca tcctatcatg aatgcgaatg 3391801 atctcccgca tagcctgtcg ggtacagcct gtacagattt ctgaaatgtg attcaaccat 3391861 acaatacact attatatcgc tctcaaaaag aaagtggtga aatgagaatc ggctgttaaa 3391921 aaaaaccaaa caattttctt cttttgaccg gctgcggagg ctgtctgaag atggtctgat 3391981 tccgcaggag aagctctgca ttttccgtca gcatataagg aagttccgag ccgaattctt 3392041 tctctagaac ataaagagcc tcttgagtgt gaaaatttct cgttttcaca ttatgggcat 3392101 ctgaggctac gaaatggatc aaattggctt caaccagccg gagagaaaat gctttcagct 3392161 gcttgccgaa gatccccgca agacttcctg aagtaatctg agatgctgct cctttttcca 3392221 caagatgata cagcaaggac gggttttcgc gaatttccct gttgcgttca ggatgggcga 3392281 taaccggaat atatcctttc agctgcaaat cataaaaaag ctgctccgca tatcggggaa 3392341 cgtgatcaaa cggaaactca atcaagatgt attttgtatc attcagcgaa agcagctgac 3392401 gtttggcaag gtcttgttcc acctcgccgt agattctgat ttcctgtccc ggaagcacat 3392461 gtaaaggaat gtcttctttg attaaacgtt tgtttaactg atctgctgct tctctgactg 3392521 cggctggctc gtttttatac acaccgttgt tatgatgagg tgtcgcaatg atcgtccgga 3392581 ttccctgacg aacagctgct cttgccattt ctatgctgtc ggccgaatca cctgccccgt 3392641 catccattgc gggaagaatg tgacagtgaa tatcgatcat gtcctagccc ccttttttcg 3392701 caaaaataaa taacgggcac gatgcacgtt atttattttt gcatgaaatt gtccttggtt 3392761 ccgtaatatc cgtattcaga gtgcttcgaa agctttttgc cgttcataat cgccccaagg 3392821 agcttgcttt tgcacgttgc aagcgcctct ttcgcttttg cggcttgttc tttttctgtt 3392881 ttcccgcttg aaataaccag aacagaaccg tctgccacgt tgcctaaaat ctgtgcatct 3392941 gctacggcaa gaataggcgg cgtatcaaaa atgaccatat catatgccgc acacgcttcg 3393001 tatgcaagct ccttcatcca cttcgaggag agaagctcgg ccgggtttgg cgggatcggg 3393061 ccgctcgtca gcacgtcaag atgtttttca ttcgatgctt gtacagcctg ctccatagag 3393121 cttttcttta ataaaacaga tgttaagcca accgtatttt caagaaaaaa agccgtatgt 3393181 actgttggtt ttcgcaaatc agcatcaatc aggagcactt tttttccctg ttgggcgaat 3393241 acgacagcca ggttggcggc cgttgttgat tttccttccc ccggacaagc cgatgtaatc 3393301 atgactgatt tcatttgccg gtccactgaa gcaaattcta tattcgtgcg aatcgtccga 3393361 tattgttcag agttcaagga tttcggctct gtcattgcaa tgacatttct ctgcatccgc 3393421 gagcctctgt tttttctaag cgccaaaatg tccactcccc gttttttcag attggaaacc 3393481 ctgtaaggtc tttgctgttt tctgctcatt cgcaatggtg gaaactgtcc ctaaaacagg 3393541 tatgtccagc aaggattcga gctgctcttc cgatttgatc gtattatcca aatgctcaag 3393601 caggaaggcc agtccgatgc ttcccgccaa tccggccgca aacgcgatgg caatgtttag 3393661 tagcggcttt ggcgatacag gggacgggtg ttctgaaacc tcggcttttg acagaatgct 3393721 gacattgtca acattcataa tggatgtgat tttgtcttga aaaacagatg ctatagtatt 3393781 ggcaatatga gccgctgttt ccgcgttttc atccctgact gatatgttga ccacttggga 3393841 gtcctgttcg ctggatacgg taattttgtc attcagttct tgggatgtca tcgacaggcc 3393901 catttcttta atgacttcat ctaagatggc agggctctta atgatgacat tgtacgtatt 3393961 gattaactga agattggttt ggacatcgtt aaattggact tcttttcgtt catttttcga 3394021 ttggttgacc agaatctgag ttgaattttc atagatgggt gtaagtgcga agaaactaat 3394081 gagtccgccg gcagcagtgg cagccgcggt tacaatcata atcaaaagta tgcgttttgt 3394141 taacgttgat aatatctctt ttaagcttgt agattctccc atgatacctc caaatctctt 3394201 ataacatcct tttccatcta cgattataca acgttgaaac cgcatttctc cagcttttca 3394261 cgtgacataa ttcgacattt ttttacaatg cgttatgtta gtacttttta tgtaagcgct 3394321 atatttactg tgttgacagt gctgtctcat tttctcttat tcgggcagtc acgttctctc 3394381 gcataaaaaa atcccgctaa aggcgtgcgg gatttttatg ttgcatatcc atttttaata 3394441 tgagaaatca aattttcaag catttccttc gtcgtcatct cagatgactg ctcaccaatt 3394501 tcatgtgcat gcatcaaaat tttcagaaat tcttcttgat tcaatttctt ttcactcatc 3394561 ttttttttcc tttcagcttc cattaagttg aaaacacgat tattatatga tgctggttat 3394621 caatttgcaa tctctaatac atcattcgac acatcctatt ttttatgtcc ttttttagga 3394681 aaaacttttt aaggccgatg tgttgcgata taatagagaa attggatctt tttattacgt 3394741 gactcggtta ggagcgataa tcatgcttca gaatatgatt tccaaagacg atgtgctggc 3394801 atctgctgaa cagttaaaag aacttcttcc ttacaatgag gaaaatgttc agctgatcaa 3394861 aaaagccctt attttatatc ggcaggattc agtctatcgt ttacaagcag tgagtccgac 3394921 ggaagttacg gcttacgtgc aggatgttgt gcctgtgcgg gtcacattga acttgtttgt 3394981 catagtcaaa agcggctgtt catgtccgtc cggaagaatc tgccgccata tgctggctgt 3395041 gtttttatat gtatatgcaa tgttcgagcg agtgggtact tttacagagt attggctgga 3395101 gagggaaaag cttgaggaaa gcaaagagct cgtccgccgc cagtttcagg aaaaggtgct 3395161 gcctaatgaa gaatcacttt caagctggct tgcttttttt gattcagagt tttctctctg 3395221 gcaggcacgt acgccagaag gcagccaaaa catgcagggc ctctattacg gctacctgtc 3395281 cgcattaaaa aaacatgcgc cgaacaagcc ggagctgaaa agcctgtatc agattcattc 3395341 cgcgattgcg gtttggcttc gcatgttcac attgattgaa gcgggcaagc taaaccccga 3395401 acaagatttt tattccctca atccgtacgt tgaacagctg atggatacaa tctacagctc 3395461 tattgataaa ttaaaaacgt acgcgctgtc ttttgcgctt gatccgtttt tggataaaac 3395521 accggatgtt atccggcatt tgctgttgaa agaagaaatt ttccaatatg aacgcatccg 3395581 cgtcttcggt gaaatttgga gtgcgctgct gtcgcggcca aaatgggtgg cacgcgaaca 3395641 ggagatattg aaaaaagaag caggacggcg tttttctccc gaattgcaat tcgggcgcct 3395701 gcatttggaa ttcctgcaaa aaaatgatga cgttattttt gaggaagcgg atcaattccc 3395761 gccggaagcg ctcccttata cattccaatg gctgagtgaa atgactgcca agaaggactg 3395821 gaaacggctt aaaacatggt accagcaaat tgaaccaatt gcgatgggtt atacgaagct 3395881 ggataagccg tttaaagaga ttcgcgatgt gatcggcgag ctgttccttc tgttgaatgc 3395941 ctatgtgcag caaaccaatg atcaagcgct gtttgagcgc tttgccgcgg gctgtctgcc 3396001 gtatacgttc acagaataca gccatcattt atatgaaaaa aaacgctatg ccgagtggat 3396061 tgaaattcat agccttgtcg gcttttccat caatgaaatg gataaaatga tgctcaagga 3396121 aattgcagcg agcgaccctg aggcgcttat accggcttac catagagaag tggctttttt 3396181 cattgatcag aagaaccgta gctcgtacaa ggaagccgcc cggtatttga aaaaattgcg 3396241 caccctgtac aaaaaagcga aaaagcagaa ggtgtgggag cggtatattc agctgctgag 3396301 ctcgcattac aagcgcctgc gtgcgcttca agaagaactg cagaaaggaa agttgattga 3396361 tggcgagtct taaagaaatt ctcatccacg tcgaacaaat ggaagatggg tcatttacgc 3396421 tctcagcctt tgatgagaat gagcagcctc ttccctacag ccatatgaaa aagcatttgt 3396481 tccaatggca tgaatcctca ttttacggaa cctttctaga ggatgtcagc ttcatcggga 3396541 cgactgctgt ccttctatct ccatggatga ctgtagagct tctcggcaaa aactcgttca 3396601 actcattcag ctccgtgcag cttacagaag aaacggagcc gctgatcgag gcggcatcga 3396661 ccatctatga atttatcgcg gacggcgatt ttatgcctga ctatgacgca tggacaaacg 3396721 gtgtttttcg ctggaaggac cgcgataata tactggaagg ctttactgcg gaatggtttt 3396781 ccgctgccgt acaggattac atccagtacg acgatgacct gcgggagaaa tgggaacata 3396841 tcaaggaaaa atcgcctgcg gttacgacat tccgtggcca ttttcttgat gaagaggatt 3396901 ttctggaagg cattggctgg attgacgatc aatctccatt tactgtcggc ttgcgcttaa 3396961 atgaaccgga ctttgacgga gacgaatgga agatcgagat gtttttacgc gataaaaaga 3397021 gcggtgctgt agaattcttt gacggactga agagcctcaa aaaatcgtgg caggcgtaca 3397081 gcgataaaat cgcgcgtgag caggaccgct ttcacagaac ggttccgtgg ctgtcgtttg 3397141 attccgggac aacgctgatc tcggaggaag aagcctggat cttcctgtca gaagcaagtg 3397201 agacgcttgt cgatatgggg gtagaaatcc tcctgccgtc ctggtggcag attgtcagag 3397261 acagcaacat gatgctgaaa gcaaaggtgt cttcctcccc gcgcggcgag tcatttgtcg 3397321 gcatgaatgc actgcttgat ttcaactggc ggtttgcgac aaatggaatt gaactgactg 3397381 aggctgaatt taatgagctt gtcgccagca acaggcgcct tgttaatatc cgcgggcaat 3397441 gggttaaaat cgatccgcag tttatcaaac agatgaaacg cctgatggaa aaagcagaat 3397501 cagagggact ccacatgtct gatattctgg cgcgggagct aatggatcag caggatggcg 3397561 gacttgagga ttcggacctg attgatacat ctgcttttgc cggcattcag tttgatctgt 3397621 ctaaacagct caggtcactg attcgaaagc tcactgccgc ggaaaacctg ccggagcaca 3397681 aagtcagtcc ttctttcaaa ggaacgctcc gcccttatca gaaatacggc atgaactggc 3397741 tgctgtttct gcgggaaagc ggttttggcg cctgtctggc tgacgatatg gggcttggga 3397801 aaacgattca aatgatcgcc tatttccttc acgtgaagga aagcggccga caaaaaacgc 3397861 ctcatttgat tattgcgccg acatccgtac ttggcaactg gcagcgggag cttcaaacct 3397921 ttgcccctga tctgtctgtc gcgctccatt atgggccgcg ccggccaaag ggtgatgatt 3397981 tcgccgcgca ttatgaaaac gcagacgtgg tgctcacttc atacggtctg tcacatgccg 3398041 atactgaaga gctttcttct gtgacatgga acacgatctg ccttgatgaa gcgcaaaata 3398101 ttaaaaacgc gcatacgaag caatcacgcg caatcaggaa gctgaagggg cttcaccata 3398161 tcgcgctgag cggcacgccg atggaaaacc gactgactga gctgtggtct atttttgact 3398221 tcatgaataa aggctacctc ggcagtttga ccggcttcca taaacgctat gtgctgccga 3398281 tcgaaaaaga ccgggacgaa aagagaatcg gacagcttca gcaattaatc cggccattcc 3398341 ttctccgccg gacgaaacgg gatgaagagg tcgcgcttaa tcttcctgag aagctggaag 3398401 aaaaagaatt tatccctctg tcagccgagc aggcatccct ttatgagcag ctcgtcaaag 3398461 acacttttga ccatatgaca tccctgaccg gcatgcagcg aaaagcgctg atcctcagca 3398521 tgcttggacg gctcaagcaa atatgcgatc atcccgcgct ttatttaaag gaagagcaaa 3398581 ccgagctgct ggccggcaga tcagtcaagc tcgaaaaatt gctggaactg atgacagcga 3398641 tccgcgccca aaacgaaagc tgcctgattt tcacgcaata cattcagatg gggaacatga 3398701 tgaagcggct gcttgaaaaa acgttcgggg aacctgtgca atttttaaat gggagtctct 3398761 ccaagcaaga gcgggataca ctcgttgaga aatttcaaag gaaagaatat ccgacactga 3398821 ttctttcact caaagctgga ggcaccggac ttaatttgac cgccgccaat cacgtcatcc 3398881 attatgacag atggtggaac ccggcggttg aaaatcaagc gactgaccgt gcataccgca 3398941 taggccagga gcgctttgtc cacgttcata aaatgattac gacaggaaca atcgaagaaa 3399001 aaattgatgt catgcttgaa tccaagcaaa ccctgaacga tcaaattatc caaagtgaaa 3399061 actggattac cgagctttcc acacaggagc tcgaagaatt gtttacatta agcgctacag 3399121 cgcaataatc atgactaaaa aagctggctc taaaagagcc agcttttttc cgttcatagc 3399181 cgtcacgccg aatttccaaa aaatccgtta cgccggttat caacagggtg cgcttttgtg 3399241 gcagcacata tacttacaac aaatgtttca tcatatgtgc gacaccgtgt tcgtcattgg 3399301 ttaaggtgac agcatcggct atcgatttga tgtcttcccg ggcattgccc atcgctacac 3399361 cttttcccgc agcctccagc atcgatttgt catttaaact gtcacctaca gcagcagttt 3399421 cctcgagcgg aatattcagc tgttttgcaa gcctcttcag cgcctgcccc ttggaagctt 3399481 tgcgggaaga aagctcaaag ttgtgctcag ccgaactgac aagcgtcaaa tcttcggcat 3399541 gctcatatct tttccagcct gcctcaagct tttctttgaa gaaagaaaag ccgagaatat 3399601 tgtaaaaatc gattggctca tcggcttcaa acagctcttg aaaggagtta atgtaagcaa 3399661 agcccgattg gctgtattgc acctcggccg cctgcttaag gacagaaaga tccgcttccg 3399721 gatttgcgct tctgaatctg tcgagctcaa catcaagaag ttctctgccg ttttgcggcg 3399781 tataaatcgc tgaacctgtg aatacctcat aataatagtt ttccgactca agccatgaga 3399841 gaatgtcata cgcccgtttc ttatcaatcg tttcgtgatg ataaagcctg ccctcgggat 3399901 cgtgaatgac ggcgccgttt gcactgatga cccatgtttt gatccccagc ggttcaaaga 3399961 ttgacatgac gtcaaaatga gcgcgcccag ttgacaccac cacttcaatg ccgtcccgct 3400021 gcgcctgccg cagtgcgttt tcattttcca agcttacctg atgcttgctg ttgagtaagg 3400081 ttccatctaa gtcaatcgca attaatttca cgtttgtcag tcctttcctt catcctgctc 3400141 tgtcacgaga agctcaacgc cgtttcggtc aagcaagtca caaaatgcct gattcggcag 3400201 cctgtctgta atcaagaggt cgatttcatt cagctccgca tactgataaa aactggtgct 3400261 gcccagctta gaatggtctg caagcgcaat tacctgcttt gcctgctgta tcattttccg 3400321 cttcaccatg ccatcctctt catgcgcaat tgtaatgcca tgttcggaaa tgccgaccac 3400381 accaatcagc gctttatcaa catggtagct tgagagcttt tcaatcacag aggacccgta 3400441 cagaaagcgg tgctcctttt ccagcttgcc tcccagcaga taaatttcaa ttccctcttt 3400501 atcggacagc acatccgcaa gattaatcga attggtgatt acggtacaat caaccgcatt 3400561 caaatgcttt gcacatgcct gaacagttgt agaggcgtct aaaatcaccc ggtctccatc 3400621 atgaataagc gatgctgcaa gcctgccgat cttatttttt tcctcagaca ctgttttcag 3400681 gcggccggaa tagctttgaa ttttctgatg cacagtcggt aaaatggcgc cgcctcttgt 3400741 gcggatgatg gcattctgtt cctcaagttt cacaagatct cgtcgcgctg tatcccttga 3400801 cacttgcagg agcgtacaga tctgctccgt tgtaattcgg ttatgctgtt ttaaaaaatc 3400861 caaaatcgct actaatcttt cttcttggta cacgccctca ttccttttct cagcaatcat 3400921 ttataagtaa ttataagttt ttatttgatt ttattcaaca ttaataagtg attttaagta 3400981 aaaatgcgtc gagagaacca atttttccta agtaggcaaa aagaaagaac cagtctggtc 3401041 gactggtcaa ttttgagggg atgatgcgaa gatccggata atagtgaatg gatagataac 3401101 gggaggagca ggggtgtcaa tcagcagctt tttcccgggg tttagggtcc ataaaacgaa 3401161 cagtgtcagc caacacttct gttacataca cgttaacgcc ttcctcgttt tcatagcttc 3401221 ttgtctgaat ccgtccgctt acgccgacga gagaaccttt ttggcaatac aacgccgtgt 3401281 tttcagctgt ttttctccaa agtgtgcaat tgacgtaatc agcttcgatt tcacctgaag 3401341 cattcttgaa gctgcggttc accgcgagcg taacatgtgc aactgccgca ccggcggaag 3401401 tgtagcgaag atcaggatct tttgtaagac gtccgacaag catgacctga ttgaacatgc 3401461 gattcctcct ctccttgcgg ttgtatgtat tgtaaatgat gcaacaagaa aagaaaaacg 3401521 cttaaaaatg gctttcagcc tctgttttta tctttcgttt tcatttttcc ttcagctaaa 3401581 aacatctttt gcttttttcc tttgaagaaa tatgtacttt ttaaaaaacg gaaaaagatt 3401641 tgctttgtca gccagttttg cgtattcatg cgcacatagg aagagccatc ccacgcaaac 3401701 cactgaaagc tcaatttttt ttccggcatt gacagcttga ttttatactg ctccatgcca 3401761 tcttgtgttt cgtataaaaa acttattctt ccttttttgt tcagatgaac ctcaaacact 3401821 tctttacggc ttaacatata tgttacttcc ttttgaatca aatgactttc agaaggaacg 3401881 ccgtcaatat aaatttcttt taaacgaaat tgattcatac cacatctctc cgtaatccat 3401941 agtcagttac agtataatga aaaaatagaa attattaaat gtttcgctca tacaaaattc 3402001 tttagcccca acattgcagg attttttcct cgaaaacgtt tatgttataa tggaaggcaa 3402061 gaaaactttg gaagtaatcg gggtgagaag aaatgaaaac ctttaaactg gttgacctga 3402121 atgtggaacg agtggacaag gaagaacaat caattgaaca gtttcccctt attgacggac 3402181 tgattataaa taaagaagac ggtgaaaatc actggctgat tgaggcgctt gtacagaaag 3402241 aacatctgtc tttttttgaa cagcttcaaa acagccaatc tgaagccaaa gtatttgtaa 3402301 cgatcacgaa aaaaagcaat cgccccgccc agctgacagc agcagtgaaa aatatcgtca 3402361 agctggaaga aagcattcag gttttactct acggacaaat ggtcacaaga aaacagcagg 3402421 gcactgaaac cattctcgag tcccttgtaa aagagggcta tacaggaaca aaactcattg 3402481 aggcatttaa gcaaaaatta taaatatgag ggggcatgtt ccccaaaaca gactcagaac 3402541 cgaagagcat cacaatagac atttagaata gatatgttct gcatgaaaaa agctgccgtt 3402601 ttgaacggca gcttttctct tcgtgctttc actcttgcat atttaatttg tatggccaaa 3402661 agaatcaacc aattcccctt tcacaacgag gcgcccttcg gttttgaccg ccttgtcaca 3402721 tgtgattaac gtaatctcct ttttgtttgt ctcctcaact acatctgcat ccatttccga 3402781 tatgatgtct ttcgatgtta cagaatagat ataatccttt ttaaaatccg tgatgacaat 3402841 ttgggcacct gtttttatgt tttccagagg tccgaacaga agattctttt gcttcaaatg 3402901 atggcccgcc aacggataat ttccctcacc cattttttga tcccggcgca ttgttgccgc 3402961 ccctatcaaa agattttcat tggttgtgcc ttttacgatc ggaagctcca gatcgacact 3403021 tttaattgtt atccgccgcc ttgattgtga agtaaaaata agtatatttc acgtgctttc 3403081 gacgttctcc acttgactgg aatgctttaa tggcgatccc ggcatctgta gcttcaggct 3403141 ttccttcaga ggaatcagaa atctcaaact ctattttctc agtgttcagc acataaccgg 3403201 ctggcgcttt cgtttcaaca aaagcgtatt gtcccggtgc aaggcctgaa gctgtgactt 3403261 gatgatgccg gatatgactg gtttcgaagt ctgtatgaaa attcgcgaac gattcagcat 3403321 ggttgatctt ccggttctga tcattacagc tgccattatc ggccatgaca aatacaaggc 3403381 ttttcatgcc ggagcgaatg acattttgca aaaaccctat cattactctg aatttatggc 3403441 gcgtattcaa aacctgataa tgatgaaaca tacagcaaat caagccacaa gaatggaaat 3403501 ggcgtttctc cagtcgcaaa tcaagcctca ttttctttat aatgtattaa acacgattat 3403561 ttctctcact catttggata ttgaaaaggc ccgggaggta acagaggaat ttaccaacta 3403621 tttaagaatg agttttgact ttcaaaatac atcagccatc agttccttca gacatgagct 3403681 ttcgattatc aattcctatc tttctataga aaagacgcga ttcagtaatc ggcttgaggt 3403741 tcttttcgat atagatgaag acattgactt tatccttccg cctttaatga ttcagccctt 3403801 ggtggaaaat gccgttcttc acggtgtcag caagaaaaga ggcggaggat ggatcaaact 3403861 gacagctaaa aaacaaagca aaaatgagta tcacatcaaa gtagaggata acggtcccgg 3403921 gataactccg gaaaaacaaa tagatctctt atcaacggat tttgatcgca gcgtcggatt 3403981 gaaaaatatc aatcagcggc tgaaacattt ttgcggaagc gagttgatga tcagcagcac 3404041 tccggatgca ggcacctctg tctcaatgct cattcatctc gctgaaacaa caggaagccc 3404101 taaagaactg aaggacacag aacgaaccta aacgaaaatt gagataaaaa aagacgccgt 3404161 ttctaacggc atctttttta ttccggcgac tttgcttgct gcttcagcag gtctctgatt 3404221 tctttcagca gctcctcctg cgcatccacc gcttcctccg cagcctcttc ttctgcttct 3404281 tttttgcgcc ttaacccatt caaagtccga atgacgataa aaatggagaa cgatataatt 3404341 aagaagttca caatcgtctg tataaagctg ccatatttca ctacagcatc gccaaacgta 3404401 aacgacaggc ctgaaaagtc aagccctccc agcagcaaac cgaccaaagg cataatgata 3404461 tcatttacta gagatgtgac gatctttccg aaagcgccgc ctatcacaac accaatcgca 3404521 aggtctacga tattcccccg catggcaaag gctttaaatt cattccacat acaatcacct 3404581 gcttttctat atttgtaaag aaaaaaagac aaatgtgccg ctggccatct gccttttttc 3404641 aattattctc cgagggcaaa agtcagttct acttcgcaaa cgacttcgcc atcaactgtg 3404701 gcaacgcctt ttccgcgccc gattgtgccg cgggcacgaa tgatttcaac ctcaaggtga 3404761 agctggtcac caggcttgac ttgtttttta aagcggcagt tatcaatgcc tgcaaaaaaa 3404821 gccagtctgc cgcggttttc ttctttaatc aacatcgcaa cagctccgac ttgagcgagt 3404881 gcttctacga ttaatacgcc gggcataacc gggtactgag gaaaatgtcc gttaaagaac 3404941 tcttcattag cggttacatt tttatagcct tttgcccgtt tgccctcttc aacttccgta 3405001 atccgatcca caagcaaaaa cggataacgg tgaggaataa tttctttaat ttgctgagta 3405061 tcaagcattg tcttgacatc tccttcatct gcattagtat gtatagcaat catcaaagat 3405121 ccaatctgta catttgaaaa gtatattatg aattaatctc tttttcaacc gcgctaaaat 3405181 gtaaccaact gtcaatgaga gccgtcaaaa gttatgatat gataattata gattttacca 3405241 atagcaaaga ggtaggaaaa tgatttcgaa gtttattgaa aaaagaatgc taaacatgtt 3405301 agacgagtgg tattccgcaa tgagcaaacg caaaatgaat cacgtttgca cactgaaaga 3405361 gaaaattgat cagcaccttc caaagatcaa aaagaacaca aaactttgga tgcgttatca 3405421 attgtttcag gcccgccatc agctgctttt tgaaaaccag aacggactcg attcattgtt 3405481 cgatggccta tatggcctgg aagacaaaat ggatgatgaa ttgaaatatt atctgtattt 3405541 tttctctggg ttatatgaga tggtaaaaac agctccgaaa catgcagtac atcattttaa 3405601 aaaagctgaa cagtacctgg ccgccattca caatacgttt gaagccgctg atttatatta 3405661 tcaaaccgcc ggcgcctatt acttgatgaa atcaccgccg ctttccgtcc aatacgtcaa 3405721 aaaagcatta cacatctatt tgcaccaatt cggctatatc aaaaaggtaa tcacctgtaa 3405781 acttttgctc gccgtgaatt atattgatca agaacgctat gaaaaagctg aacagctttt 3405841 caaagaaatc attaagaaaa cccagcaact acatgacgaa aacctgctat gccacgctta 3405901 ttataacctt ggctttttaa aagcgaccga gaaaaaagac caggaagcgc ttctttactt 3405961 tagaaaagta ttaaagaatc aagaatttga aatgaattca ccagtctcat atcttcattg 3406021 tgtgtacgag tctgtcagag cgctttttaa aacagggaac atcacagaag ctaaagccgt 3406081 ccttcaaaaa ggaaaagaat tatctgaaaa ggtagacatt caaaccattt atttaaaatt 3406141 aaaaacgctt gaagccctct acacatcagc cgaagaccct tatgagcagc tgctcgaata 3406201 tgtgcttgaa ttagaaaaaa tcgaggcgtg ggtggattta gaagtgctgt tagaagatat 3406261 tacggaatac tacaaaaaaa aggacgattt cgaaaaagcc gcttttttta tcatgcgcgg 3406321 ctgattgaaa aacgcccatt ttcttattat ctgactgaat tgattaaacc gagcatttga 3406381 tctcccattg tgatcgttct gctgttcagc tgatatgaac gctgggacgt gatcaaatct 3406441 gtcatttgtt ctgaaatatc gacattggac atctcaagtg agccctgctg catgccgatg 3406501 ttttgtctat tagcgccgtt cagctcttca aaagctgccg cattatcaat agagaaaagg 3406561 ttattccctt cggatttcag ctcttgaggg ttattcactt ggacaacgcc aagattaaac 3406621 cgctgaaccg cgtttccgtc agatgcggtt aaggtgccgt tcttattaat ggtgatattc 3406681 ttcattgagc tgtcgatgtt cactgtattg ccgttctcat caagtacggg atacccattt 3406741 ccagtgacga gctgcagctg gttggcattc gcagcggacg gcgttacata cagcgccccg 3406801 tccctcgtat actggcggtt tccatttaca tttacctgaa gatactggta tggagacgta 3406861 aatgcgatat ccagatcgcg atcggtcttc tgaatgcttc cttgatcaga gactaggcgt 3406921 gaactcatca tcgctccgac gccaaggcgc aagccgggcg gcgtttttcg ggcttttgcc 3406981 acttcctcgt ttttttcatc aacctgatcg aattgctgtc tgacaagctc agaaaaattc 3407041 gtatcttttg ccttatagcc ggttgtgttg ctgtttgaaa ggttgctgct gattgtgtca 3407101 atctgctgct gcagctggtt taaggttgtt gatgccgtta gcattgacct gagcatagtt 3407161 gatgtccccc gtttttttct tccgttttct taaatttttc caatttcatt tgctgcttta 3407221 tccatacttt tatcgtaagc ctgaataacc ttctgattcg cctcaaacga tctgtacgct 3407281 tcagtcattt ctgtataggc gcttgtcaca tccacgtttg aaagctctga gacgccttgt 3407341 tttaatgaat aggctacctg attatttccg gctgcgcttg gcagatcatt accgtccgcc 3407401 gtgctgtaca aatcatttcc gtcccgtttg agattgcgga catcttccgc cattctgaca 3407461 tcaatctggc cggctgtgcg tccgttcgtt gtcacagtac cgttttcaga cacagtgaaa 3407521 ttctcattat caacagtgat tggctggcga tccgtcgata aaatagggcg tccgttgatc 3407581 gtcagctgat tgttctcatt tagtgaaaat gtgctgcttt ttgaataacg gattccatcc 3407641 gctgtttgaa ccggataaaa aagagcagct ttttcattgg tttccgcact catcggaact 3407701 tgattttcga tcaatgcaat gtctgtaggc tggtctgtgg acttcaggct tccctgtgta 3407761 aagagaggct tgagctcctg catatatact ccggtattca cggaaccgat ttccgtcctt 3407821 gatgtcccgg ccggagattt tgattctatt ctgctgagca gcatctcagg gaacgcgcgc 3407881 atagagcctt gatcagcttt atatcctgat gtatttgcgt tagcaatatt atttgaaagc 3407941 atttccgttc ttcgctgctg ggcaatcatt gcggatgttg ctgtatataa tccttttaac 3408001 aaatttccca cctctaaaaa tggcattttt tccagttgtc atataggaac gttcgttcta 3408061 taataaaaac tcagtatttt atcctattat cgtcatttaa catcttttcg tgaaggcttt 3408121 ttcataaaaa aacctcattc tttttcagaa tgaggtttgt gaaatcagct tagtttgcgt 3408181 ttaggaagct tgtccatatt atcaagcatg acacctgtgc cgatggctac gcaatccata 3408241 ggattttcag caacgaggac cggtaccttc agctcttcag caagcagctg gtcaaggccg 3408301 tttaagagcg cgcctccgcc ggtaataata acgccgcggt caataatatc agcagaaagt 3408361 tcaggcggtg ttctttcgag cacttgtttt gcagcctgaa caataacagc gacagattca 3408421 cgaagggctt cttcaacttc tttactgttt actgtaattg ttcttggaag accggaaacc 3408481 atgtcccgtc cgcgaatgga aatttcctcg tgacgtgcgt ctgggaaaac agttgcgact 3408541 ttaatcttaa tatcctccgc agtacgttcg ccgatcagca gcttgtactc gcgtttgata 3408601 taatttaaga tttccatgtc aaacttgtcc ccagccattt taatagaaga ggaggtgaca 3408661 atatcgccca ttgaaataac cgcgatatcc gtcgtcccgc ctccgatgtc tacaaccatg 3408721 ttaccgcttg gctggaatat ttccataccc gcgccgatag cggcaacttt aggttcttct 3408781 tcaaggtaca catgtttccc gccgcttttt tctgcagctt ctttaattgc tttttgctca 3408841 acggatgtaa tattcgtcgg gcagcaaatg agcatgcgcg gctttgagaa caggcctttt 3408901 acattcagct tgttaataaa atgtttcagc attgcttctg ttacttcaaa gtcagcaata 3408961 actccgtctt tcagcgggcg aatcgcaaca atattcccag gtgtacgtcc aaccattcgt 3409021 cttgcctctt cgccaaccgc cagcactttg ccgctgtttt tatcaagtgc aacaacggaa 3409081 ggttcattca gaacaattcc tttaccttta acatggatca gtacatttgc agtaccgagg 3409141 tcaataccaa tatcccttgc aaacatctat ttatatcctc cttgaaaatc tgtttcacag 3409201 taaatatcca cattgtgccc taattatata tattatcata aaatatagaa aaaaagttgg 3409261 aagcacaata agttctttac aaatttttgc ggatgtttta tgaacgattt caagaaggca 3409321 atgccaggtg attacgattg ctgaacaggc tctccttcga gaatttcatc ttttttatat 3409381 ttgagctttg tcgcttctcc tcctcttaaa tgcctgatgg atttatgata atcgagtatt 3409441 tctttcactt cgtttgccaa gtcggggtta atttcaggca gacgctctgt taaatccttg 3409501 tgtactgtac ttttggaaac accaaattcc ttcgcaatga cacgaacggt tttctttgtc 3409561 tccacgatgt acttccctat cttgattgtt cgctctttga tgtaatcgtg cacaccactc 3409621 gacctcccta aaatggatgt gagaagtgtg aaatgagatc cgtattctgt aaagagtcgt 3409681 tcattatgcc gcttcttcgt tgtatggttt taaaagtaag tttgtgaaat atgcccacga 3409741 tccctcacct caaacactct ctttgttagg tttgtaacag tgtattagca ttcttttggg 3409801 aatatgctaa aaactcaata aggacaaggg gtgaaacgaa ctttttcaga ttcagcaaac 3409861 tatttcgcgt cactaaattt tcatctttac aactattgat cgctcctgta aaatgaaata 3409921 agcaattagt tacttaggta agttttttag aaggagaccg acatgtccta cgtcaacaga 3409981 cacctcattc atcaaatcaa ccaaagcgcc cgcctgattg ccaagaaagc caatgaacag 3410041 ctagagccat tcggccttta ttcatctcaa tggtcagttt tatattgttt gcgtacgatc 3410101 ggaccaatga ctcaaaaaga gatttggtcc tatttaaatg tggaagcgcc gactgtgact 3410161 cggacgatca aacgcctgga ggagaacggc tgggttcaga gacggcaagg tgaagacaaa 3410221 cgggaaaaac ttgttgtcct cacaaaagaa gccgagaaaa aatacgaaga aatcaatgtg 3410281 aaaatgttga aattcgagga agagctgctt gcagatttcc gggatgaaga taaagaagct 3410341 ttttctcatt tattccgcat gtttttacaa caatgaaaat aaggaagtga catacatttg 3410401 aaaaaagcgg atgcgatatg gaccaaggat tttattatgg tcctgcttgt caatttattt 3410461 gtgtttgtgt tcttttatac atttttaact gtattgccga tctatacact gcaagagctt 3410521 ggcggcacag aatcacaagg cgggctttta atcagcctgt tccttctgtc tgcgatcatt 3410581 acacggcctt tctccggagc catcgttgag cgtttcggga agaaaagaat ggcgattgta 3410641 tcaatggcgc tcttcgccct atcatctttt ctgtatatgc cgattcataa cttttccctg 3410701 ctgctcggat tgcggttctt ccaagggatt tggttcagca ttttaacgac tgttacaggt 3410761 gcaattgccg ctgatattat tccagccaaa cggcgcggtg aagggcttgg atactttgcc 3410821 atgtctatga acctcgctat ggcgatcggg cctttccttg gcctgaattt gatgagagtg 3410881 gtaagctttc ctgtattctt tacagccttt gcgctgttta tggttgcggg cttacttgtt 3410941 tcgttcttga taaaagtgcc gcaaagtaag gacagcggca cgactgtatt ccgttttgcg 3411001 ttctcggata tgtttgaaaa gggcgcactc aaaattgcga cggtcggttt gtttatttct 3411061 ttctgttatt caacagtcac atcatatctg tctgtattcg ccaaatcagt tgacctttcg 3411121 gatatcagcg gatatttctt tgtttgtttt gcggtgacaa tgatgattgc acgcccgttc 3411181 acagggaaat tgttcgacaa agtcggaccg ggcattgtca tttatccatc aatcctgatt 3411241 ttctctgtcg gactctgcat gctgtccttc acacatagcg gcttaatgct tctgctttca 3411301 ggggcggtta tcggtcttgg ctacggatca atcgttcctt gcatgcaaac attggcgatt 3411361 cagaaatctc cggctcaccg ctccggtttt gcgacggcaa cgttctttac cttctttgac 3411421 agcggaattg ctgtaggatc gtatgtattc ggattgtttg tagcatctgc cggcttctct 3411481 gccatttatt taacagcggg gctgttcgtt ttaattgctc tgcttctcta cacgtggagc 3411541 cagaaaaaac ctgcagaggc tgaaggaaaa gtgtctattg cagaataact tgtcagactg 3411601 ccgggaaatc ccggcagtct tttttccatt aaaacacggc gccctctcgg ttgaacgaga 3411661 gaacgccgct tatagcaatt attcaatgac aggccgcgca ggtgaatcag gatctaacga 3411721 aaaatcatag gacgcttcat cacgaaacat cggatcggca tatatggatt gttgatcgtt 3411781 ttttgttgct tttcgatacg aagaaaatga atcatattct ttctttttcc acatccatat 3411841 gccgtcttga tccgcttcct tgtggtacac gttatgattg accgtattac cttcgttttc 3411901 tgtaaagtcg tttccgataa ataatctgga atcaccggcc gtcaatatat tcttttcaat 3411961 tgtgttgttt ttcgtatcgt actgcagcag cagctgtccg ccgtacagtc cctttgtgtc 3412021 attccggtac ataatattgc gggcaatcag agaattgctg gtgccgcccc gctttttgtc 3412081 atatcctccg attgaaatac cggtgtacgc attgttgtac actttgttgt ctgtgatctg 3412141 aatggcattt gcatactttc ctttgtgttc agacgttgct tcaatcccaa tatcgttatc 3412201 gtaaactgtg ttgttcttaa tttcgatatc gtgtcctcca tcgacataaa tcccgcccgc 3412261 tgagtattca tctccataag caggattgcc gtaagtcgag ttttgataaa ctgtattgtt 3412321 ttctacgact ccgtttcgca cgtaatcgtt tttatccgcg gttccctcat aaccaattag 3412381 atcaatcccg atgttattat tgttgcggac cacattgcct gcaactgtga agccgtcgat 3412441 attaccgttc agcacaactg cttcactcgc tccaagcgtc agtttctcaa ctgtattgtc 3412501 ctcgattcgg atgtctttca tgctgccagt cccataaact gcgattccgt gagcatttcc 3412561 ttcatccgct gttgtcttaa tcccccggat gtgattatcc ttaatggcga tatgactgct 3412621 ggaccctgat acataaatcc ctatagcagt tgcttcctca gatgaaacag aaagatcttg 3412681 aattgttaaa ccgctgatgg caatgtcatg tttatcgtga atacgaataa gcggtgtttc 3412741 atattcagcg ttcgcaacgg attcaccgct aatcacgacg ttttcatttt catagtttcg 3412801 gaatgtgata ggctttccgt ccgtaccgct gtgctttaca tcaagggtct catgatacgt 3412861 gccctcccga atcatgacag ttgtgccggc agcagccttc tcagatgcgt gtgccaatgt 3412921 acgaaacggc ttttcttttg ttccttcatt ttgatcactg ccatttggcg aaacatacag 3412981 ataatcccca gatccttcct cattcgcttt tgtcttatca taaacgaaag cgaggatgac 3413041 agacgttaaa acacccgcca aaagaataaa ataccatttt ctcattttcg attcccattt 3413101 cgttttagaa tagatttcta aaaccattat aaatgttcta tttatggaaa accatttcaa 3413161 aaatatgaaa atataccgtc taaatagatc ttattcagcc tggcggacct gcgcatgttc 3413221 aactgtttca attgccaatg atgcaggcgg gtgaacacgc atcagaacaa tgtagaaaag 3413281 aaaggaaatc agcacaccta caaaccaaga aatatcgtat aagctcttca atacaggaac 3413341 atacatgcca atcagcgaaa tcagcgctcc taacattgtg gctgcaaacg cacggtaatt 3413401 gtagcccttc caatacacat accgtcctgt ttcggaatac aggtcatcta ccgagagctc 3413461 acgtttgcga atgataaaat agtcggccat catcacgcct gccaccggtc caagcatgcc 3413521 gcctattaag ccaagaaacg catacacgct tgtcgcgctc tccatcagct tccacggaac 3413581 cgtaaataaa gcgagcaacg ctgtgataaa gctgccacgt ttgaaattga tatatttcgg 3413641 cagggcattc gctatatcat aagcgggtga tacgatattc gccgcgacat ttacagagat 3413701 cgtggcgatg cagagtgtga tcacggacaa gacgatgaca taagggttat caaaccgcgc 3413761 caaaatatcg acaacatccc aaatcggctc tccgaacgcg acctgcgagc cggaggtcac 3413821 cgtaatactt gcgaatgcga acagcgcaaa cgttcccggc aaaccgtaaa attgtccttt 3413881 gatttgctct ttttgtgttt cagcaaaccg tgtaaaatca ggtatattta agatcaatgt 3413941 cgcccagatg ccgatgatgc cagtaactcc ggcagcaaac ggccagaatg tttctgaaaa 3414001 cgtatgaaac tttcctggtt gagagtatat cgggcccaat cctccagcaa tatcaacggc 3414061 ccaccatacc atgccgccaa ataccagata cactaaaggc cctgcccaca cctcaaaacg 3414121 tttaatcgac tccatgccgt gatgcaatac gagtaaatga atggcccaaa agaatacaaa 3414181 ggaaagcaaa ccggacaagt gaatgccgag aatgttccac tcgccgccaa tttctcccca 3414241 acctggccac atattcaaaa gcaaaatgtt cagtgccgtg ctacccgcaa aggtctggat 3414301 gccaagccac atgatagctg taaacgccct tagaagcgcg gggatattcg cgccgtatat 3414361 cccgtaagaa gcccgaatga tcactggaaa cggcagcccg tattttgtcc ccgcatggcc 3414421 gtttaaggca agagcgccaa ataggataag tgatgccgta ataatgatcg ccagcacctg 3414481 ccaaggcgaa aggccgatcg caattaatcc tcccacggtc gcgtaggtcg gtatgttatg 3414541 tatacatccc atccaaatgg aggcaaagtt cattgctttc cacgtccgtt tttcctgtcc 3414601 caaaggcacc agatcttcat tgctcagcct gttggattgc tgctgactct cttttaattt 3414661 catagccggc tcccctttcc atattgtcta tatgtcgtca cacgttatgt tttttgacat 3414721 tagatgtcac ttaatataac tgaagagtca gacaataaca ctggctatga tatacaattt 3414781 tcccgtttgt atttgaacag cttaaacaag aaaaagagac agacctcaga gcccgtctct 3414841 ttcttaagat gcagttttca ttaatgcagc aaatctcaca gccattaaca ggcttgctcc 3414901 gcccgctata atcataatga ttcccatcat atcaaaatgg gctgccgtga tttctttacc 3414961 aaaaagaatg ccaaggatca ccgaagacaa aatcgatcct aggtaacggc aggtttgaaa 3415021 caggcctgaa gtcgttccta ccatgttgga aggactcgtt tccagcatcg ctgcctgaag 3415081 cgcgacattg cccagtccgt agcctatacc caagagcgac agaatgaggc ctttaccgat 3415141 ggtctggaca ttgataaaaa agatggttaa gagcacggct ccagccgtca tcaaaagcgc 3415201 tcccgcaaag atcggcttga cgacaccaga tcggtcgatc catttgccgg ttagaggtga 3415261 cacaacgatg ctcattccag acataaacag cataaacagg ccgctcgttt gaacagaaag 3415321 atgcatttca tcctgaaagt aacttggcaa accaaaaaat aaacaataga agaaaacatt 3415381 caataaaata aactgaacat acacggctga caggtttcgc tgtgttttaa acagacggac 3415441 atcaataaac ggcttatccg ttttcagctc gcgccagaca aacgcacaga gcagaagcaa 3415501 gccaagcaca ccttcaaccg catgcggcga cgtgctgaac gacagcaaaa aggatagaag 3415561 gaaaatgatt cccccggcaa ataaaacaat tccaagaata tcgagctgcc gaataatggt 3415621 tttgattcct gccccttttt tctgatcttt cgggaacata tacaggccca ataagaagct 3415681 gaggataata aacggcaaat taacgataaa gatcgccggc cagcctcccc atacaatcaa 3415741 aaacccgccg gctgtcggcc ccagcgccgt catggcggac gcaaaaatag agagtacagc 3415801 caaggctgaa gcttggcgct catgaatatg attccgaatc aagccgacac ctgacggata 3415861 aatcgcactg ctccccaccg attgaaacag ccgcatgacc aataatgtca taaacgtcgg 3415921 cgcaaacggc gccccgatgg cagaaaccgc aacaagaata agcccgaata aaaacaagcg 3415981 tttccgccca atcaaatcac cgagctttcc cgttacgggc tgcgctacgg cactcgccaa 3416041 gtaaaacgag gaaatcagcc aggaaaccgt tgtaaacgag aggtgaaact catgctggat 3416101 gctatggagc gcaagagaga tcatagacga gttcagcgga ttcagcattg ttcccgaagc 3416161 cacagctgtt aaaaaaacag ctcggctttt tttcgataac atcatttcac ttgttccaga 3416221 aactcttccg ttgtccgcga tttaccgatt ctcgggaaaa taaagcgcag tgtggcttca 3416281 tgctcttcat cgctaaatgt ggacatggca tctgtaataa aaatctgctg atagccaagc 3416341 tgaaatgcct cccgtgctgt gctttccacc ccgatattcg ttgcgatgcc gcacaataca 3416401 atcgtatcaa tgccgcgacg tctcagctgc aagtctaaat ctgtgccaaa aaaagcaccc 3416461 cattgccgtt ttgtcacagt ataatcgcca tcctgcacac cgatttccgg aacaaattcg 3416521 gcccagtccg ccggcatttc ccctgaacct ccctgcgcag gctcatccgt ttgcggcttc 3416581 agggcgtccg ctccatcatg aaaggctaca tttacaaagc tgatgaaccc gttatgtttc 3416641 cgaaattcat ctacgagctt tttcgcgttc gggacaacct ggccgctttg atcaatcggc 3416701 acaattccct tttgtaaatc aatgataacc aatgctgttt tttgaaaatc aatgttgagt 3416761 gtattcatca tacgtctcct cctgatactg ttagtgtttc tcacattgca tattttactc 3416821 ttcacactgc ctaagttctt ttatgatgct tgtgaaattc tcagaaggag cgttttctca 3416881 tgatttttct tttatgtagt agtaacaggt tgtgcatacg aacaaaccgg caagcactgt 3416941 aatcataaag ggcgtcatcg cttcatcacc tgcctgctgt ctatcggttc ctgcctgaaa 3417001 atgcccatga atttgcggcg gtccatccaa agcaggataa gacacataac cattaatatc 3417061 gtgctaagat cctgcacgcc aatatcaaaa caatagttaa tcaagacgat gttcacaata 3417121 atgggcataa aaataaccgc ccctaatgca gccgttcgcg gaatcagtaa taaaacagct 3417181 gccaggattt caccaaaacc tataaacagt tcatagacat gagaataacc gaaaaatgtc 3417241 cacgcgatcg taaacccctt cccggcagcc gcctcgattt caggcgtcac ctcgccaaac 3417301 tggccaatta ccactttcgc cagaccgtac acgaaaaaat taaaggctaa aaacaatcgg 3417361 aacgtcgcgg gaatcgactt gcgtaccgct ttcctcagcc tgccgccttt attcatcata 3417421 catccccctc agtgtattat ttgatgtagt acacttaata cagtatagag tattctaatt 3417481 aatgtcaatt cccttttcag ctcatatgaa tagtttcttt tatagataca aagtcttata 3417541 tcgcaaaaaa tgccattctc cttcctttcc atccctcgat aacatttctc aaaaaccatg 3417601 tcaggaaatc ttacatgaaa atgttttatc attctttttt ctctataatg aagaaatata 3417661 ataattgctt tttattctga aagatacgga ggaatgagac atgcaaatgg gcgatacagt 3417721 ttttatgttc ttttgcgctt tactcgtgtg gctgatgacc ccgggattag cgttatttta 3417781 tggaggaatg gtaaagagca aaaatgtgct gagcactgcc atgcacagtt tctcttccat 3417841 tgccatcgtt tccatcgttt gggtgctgtt cggatataca cttgccttcg caccaggcaa 3417901 ttcaatcatc ggcgggctgg agtgggcagg cctcaaaggg gtcggatttg atccgggaga 3417961 ttacagcgat accatccccc actcgttatt tatgatgttc caaatgacgt tcgccgttct 3418021 gactacagcg attatttccg gggctttcgc agagcggatg cgattcggcg cttttctttt 3418081 attctcggtt ttatgggcct ctttggttta cacacccgta gcgcactggg tatggggcgg 3418141 cggctggatc ggccagcttg gagcgctcga tttcgctggc ggcaatgttg ttcatatttc 3418201 ctccggggtg gcaggacttg ttcttgccat tgtgctcggc aaacggaaag acggtacagc 3418261 gtcttctccg cataacctca tttacacctt cttaggagga gctttgattt ggttcggctg 3418321 gttcggcttt aacgtcggca gcgcattgac cttagatggt gtggccatgt acgcgttcat 3418381 caacacaaac accgcggctg cagccgggat cgccggctgg atcttagtag aatggatcat 3418441 taacaaaaaa ccgacaatgc tcggagcggt atctggggca atcgccgggc ttgtcgccat 3418501 tacgccggct gccggatttg tcacaccgtt cgcttccatt attatcggca tcatcggcgg 3418561 agctgtttgt ttctggggag tattctcgct taaaaagaaa ttcggatacg acgacgcgct 3418621 tgacgccttt ggcctgcacg ggatcggcgg cacatggggc ggaatcgcaa caggattatt 3418681 cgcaacaacc tctgttaact cagcgggcgc agatgggtta ttttacggtg atgcaagctt 3418741 aatctggaaa caaatcgtcg ccatcgccgc cacttatgtt tttgtattta ttgtcacttt 3418801 cgttattatt aaaattgtaa gcctcttcct tccccttcgc gcaactgaag aagaagagtc 3418861 acttgggctt gacttaacga tgcacgggga aaaagcatat caagattcta tgtgaggagt 3418921 gacgctatga gcggtcaaat gttcaaggta gaaattgtaa cgcgtccggc aaattttgaa 3418981 aagctgaagc aggaactcgg aaaaatcgga gtgacctctc tgactttctc caatgtacac 3419041 ggctgcggcc ttcaaaaagc acatacggag ctctatcgag gggtaaaaat agaaagcaat 3419101 gtatacgagc gtttaaaaat agaaattgtg gtcagcaagg ttcctgttga tcaagtgaca 3419161 gagaccgcta aaagggtgct gaaaacggga tcaccaggtg acggtaaaat atttgtctat 3419221 gaaatcagca atacgatcaa catccgcaca ggcgaagaag gacctgaagc actttaatat 3419281 cggtacgaga ttcggacact ccggatctct ttttttgtgc acagaatccc cccagaaacc 3419341 gcgattcctc ttcgaattct cttcaagcgc cgttatttca gacaatctct atttttattt 3419401 gaaacttttc atgagtaaga ttagtctact aaatataaaa atgtaaaagg tgattatttg 3419461 aactacgaaa tttttaaagc aatccatgga ctatctcatc acaattcagt tctcgattcc 3419521 attatggtct tcatcacgga atatgccatt gtcgcctatg cccttatcct attggcaatc 3419581 tggctgtttg ggaacacaca aagcagaaaa catgtgctat acgcaggcat cacaggaatt 3419641 gcaggccttg tgatcaacta tttgattacg cttgtttatt tcgaaccgcg cccgttcgtt 3419701 gcgcatacag tgcatacact gattccgcat gctgcggatg cttcatttcc aagtgaccat 3419761 acgacaggtg cattagcgat ttctattgcg atgcttttca gaaaccgcaa aatcggctgg 3419821 ccgcttgtca tttttgggct tttgacaggc ttttcgagaa tttgggtggg acatcactat 3419881 ccggtagatg tattgggcag cctcgttgtc gccatcatta tcgggttcct tttctttaga 3419941 ttttcagatc tgcttcgccc gttcgtcgat ttggtcgtga ggatctacga agccattatc 3420001 aataaactga cgaaaaaacc aaccgatcaa aatttctaag aaagacaaaa gccggcgtct 3420061 gaaatcaaga cagccggctt taatatttct catacatctc ttgttttctt cgcttcgcca 3420121 acacatataa accataaaac aacccaattc caacagcatc gatgagcaca tcccggatac 3420181 aaccattcct gctgaagaag agctgaagaa cttctgtgaa aaaagcaaac gcaaatgagc 3420241 cggctgcagc tgatcttatg ctgccccgct gtttccacag caaatatgtc agcacaaaga 3420301 aggaaaacgc gtgtccgatt ttttgaataa acgcttcagg tacagtaagc tcagtaaaat 3420361 ccataactaa aaattgagac agatcagggt gcggctgaaa atgaaaagcc accgtttgcg 3420421 atacgaccat gccgctgaag ctttccgtac agacagaaag caggataaaa aagatccagc 3420481 ctgcgagcaa taggcggttc atgacataac ctcctttata acgtacgtgc ctacatgtaa 3420541 ctacatagac ggtaaaacaa agcaaaaagt aacagaaaaa aacgcccatc acaaggatag 3420601 acgttttctt cattaagact gttcagtgtc ttctgttgtg ctgctttctt tagaaccaga 3420661 tttgtcagtt gaatcatcct ttttctcacc ggatttttct tctgttcctt tttcagttga 3420721 tccgtccttt ttctcggaag attgctgaat ggattcttct gtttcttggg tggcagcttt 3420781 ttcaatagaa gaaactggtt tgtccataaa gtttaacgga ttcattgcaa ccccatcttt 3420841 acggatttca aagtgcacgt ggtttccgct gtcttcactg taaaggttct tgccagattt 3420901 tccgatcact tgattttgtt ttactttgtc accttgctct acgcttactt cggaaagaga 3420961 ttgatacaca gtcgataaac cgtcggcatg ttctacttcc acaacatatc ccagcactgg 3421021 atctttttca gctttaacaa ccgtaccgct cagagaagca gagacatcga aatcttttcc 3421081 gtctttctca gctaagtcaa ttcctttgct taggctgtac gtgttattat aggtaacgag 3421141 tgctgcttct ttctcttctt ttgcggcatc ggtttcatag aactttttca caacagaaac 3421201 gttttcagaa tcaacaaccg gcattgcgac attttccatt gactttccta cttcaactgc 3421261 atcgtcgttg ttgtcatatg cggagtttcc gccgttatca gccaactgat cctttacctc 3421321 atcatttgat actgattgat accaaaggac agctgttaaa atgacggccg cactgactaa 3421381 gtaaattgca gggaacaccc agcgtttacg aaaaaactgc tgaagttttt tgacttgaga 3421441 agttttcttt tcttcctctc tcattgtttc atcacctcag caacattctg aacacttttc 3421501 tgaaaatata tacaacctat ccaaaaaaac ttttttagat gtagtttgca cagactgaac 3421561 gaaaatatgt atttttttga gaggagtgcc aaaaacgtat gaacatgaca ttgcgtcttg 3421621 ctgaacatag agacttggag gctgttgtgg cgatttataa ttcaacgatt gcttctcgaa 3421681 tggtaacagc cgataccgaa ccggtaactc ctgaagaccg gatggaatgg ttttcgggac 3421741 atacagagtc acgtccgctc tatgtggccg aggatgaaaa cggaaacgtc gctgcctgga 3421801 tcagctttga aacattttat ggaaggccag cctataataa aacagcggaa gtcagcatat 3421861 acattgacga agcatgccgc ggcaaaggtg ttggatcata tttgcttcaa gaagcgctcc 3421921 gcattgcccc gaatcttggc atccgctcac ttatggcctt cattttcggg cataataaac 3421981 caagcctgaa gctgtttgaa aagcacgggt ttgcagaatg gggactattc cccggcatcg 3422041 ccgaaatgga cgggaaaaga tacgatttaa aaattttagg gagagagctt tcatgattag 3422101 tctggataaa gatgaaaacg aaattgaaca tcataatgaa gaaaatagcc ttgttgaaca 3422161 ggagactgca cctgttggac aggagagccg ccagctgagc gcctccgctg tcaagtcgct 3422221 atccgacatt gccaagtggg gcaaaatttc tggcatcttg ttaatcatta tgggatcgct 3422281 tgtcactctg tctgttttga tgacagtgat tggcgccatc ccgggcgtac tgctcattat 3422341 ttcaggcgta tttttgatgc gctcagcaaa agcagccgcg gaagccgaag gaaatctaac 3422401 cggcagcgct ggcgaaagca tgcttgaaaa ttacgggaca tttataaaaa tgcagctgtt 3422461 ttatgcagca tccagtatcg ttactgtcct gatcgggatc attgtagcca ttttcgtgct 3422521 ggtggtaatc ggcattgctg cttttgagaa cacgccttcg tatgatgatc cggattctta 3422581 ttattatgag gatgatccgg tgtttgaata atgatgagac aggacagggc atgagttcca 3422641 tataaacgga accatgccta ttttatttga ctattcaaag caggccggcg taaacaccaa 3422701 atcctgaagc aagcatacaa tagacatctc tagtagagga aatcaacaaa gcaacgctgt 3422761 tacccagaaa tgaatatcaa aaaaacggat gaagtcggaa tcaatccgaa accgcacttt 3422821 ttatttcggg tgtctgcatg caaaaaaaca cacccggatc gtctggaaaa tctcaacaat 3422881 ccgggtgcag atcttcttta atacattttt ttgcgtctgt cttcctcagt caaaaattca 3422941 acaaaactcc gcatcgcaaa aggctcttcc tttatttgtc gtgcgtagga gcttttccgc 3423001 tcttctgaaa ggatttcgct ctttttgatc ctgttcagca tatagatgtg aaccgttttt 3423061 tggatttgtt tatgctgata gcctgcctct ttaaaaaatg cgagcccgag cgccgccaaa 3423121 agggcgaata tgcctgcgct gatcagggac tccctgtcag ctgaagcatg aaatagaaaa 3423181 gcagctaaat taaagagaga gaatgcagca agcggaatag caagaaaacg gtaaatgacg 3423241 gtttttttca tgaaaggctg tacggccttt tgaatttttt gcatttctgt tttgatgaac 3423301 cccggcattt gttcgactct gtaaaagttc atataatcct ccccctttat ttgatgtttc 3423361 aagcttcacg aacgttatca tatgtgttta ttttaacgca ggtgcaagct ggttttaaag 3423421 aaatctgccc gtatttttca cgaagaatct ggatcgccgc tctttattct tttaaaatgt 3423481 gagtgttata atttgtaatg ggaatcagat cactgttatt catggaatac taatggcaat 3423541 cttcttgata aatatgaatg agcggggtta caaagtgagt atttcttcca tccttttatc 3423601 actttttttc attttaaata ttcttttggc catcattgtc atcttcaaag aacggcgcga 3423661 tgccagtgca tcttgggcgt ggctgcttgt tcttttcttt attcccgttt taggctttat 3423721 tttatactta ttattcggcc ataatctcag acgcaagcat ttgtttcaat gggaagaccg 3423781 gaaaaagatt ggaattgaaa ggctgctgaa gcatcagctt gaagatttag aaaccaagca 3423841 atttcagttt aacaaccggg caacctttga taacaaagat ttaatttata tgctgattat 3423901 gaataaccat gctgtgttta cagaggataa ttcagttgac gtcattacag atggacggga 3423961 taaatttcag cggctgctga gtgacatttc aaaggctaag gatcatatcc atttacagta 3424021 ttatatttat aaaggcgatg aattaggcaa aaaattgcgg gacgctctca tccaaaaggc 3424081 gaaagaaggt gttcaggtca gagtgcttta tgatgaactc gggtccagaa cgctgagaaa 3424141 aaagtttttt aaagagcttc gcgaggctgg cgggcatgtg gaggtctttt tcccgtcaaa 3424201 gctcaggccg attaacctgc ggctgaatta ccggaaccat cgaaagcttg tgatcataga 3424261 cggtatgacc ggttatgtcg gaggctttaa cgtcggagat gagtatctag ggcttaatcc 3424321 gaaattcggt tattggcggg atacgcatat ccggctgcaa ggaacggccg tgcacgccat 3424381 ccaaacacga ttcatccttg actggaacca agcttctcat caccatacgc tgacatatat 3424441 tccaaatcac tttcctgatt acggcccaaa aggcaacgtc gggatgcaga ttgtcacaag 3424501 cggccctgat tcggaatggg aacaaattaa aaatggctac atcaaaatga tttcgaacgc 3424561 caagcgttcc attttgatac aaacacctta ttttatccca gatgcaagcc tgctggatgc 3424621 tttaaggatc gcttgccttt cgggcattga cgttaacatt atgattccga acaagcccga 3424681 tcacgccttt gtatactggg cgacactttc gtatatcggc gatctgctga aagccggagc 3424741 cactgtctat atttacgata acggctttat tcacgcgaaa accatcgtgg tggatgacga 3424801 aatcgcttca gtcggcacag cgaacattga tgtccgaagc ttcaggctga attttgaggt 3424861 taatgcattt atttacgata tcaccattgc taaaaaactg gtttcaactt ttaaagaaga 3424921 tttgctagta tccagaaaat tcacctatga ggagtatctg cagcgcccgt tgtggattcg 3424981 aataaaagaa tccgtctcgc ggctgttgtc gccgatctta taagatgcgt aaacccccgg 3425041 cctttacggc cgggggtttt cctgatggtc acagtaaatg atgattgcct cccgcaaaaa 3425101 agcggcaaga ccttctccat attgattgat tgaatcggta aatcgctcgt cagtgatata 3425161 cacttccccg agtcctctga aaatgtcgag tgtgcaatcg taatgatatt ggcaaatatg 3425221 atcgcgaaat gcccccacag cggcctgaat ctctgcatca tcgggcccat gcttcattcg 3425281 cgccgcaatt cgtctgtaaa tcgaatcaaa ttcagccatg atcgtgcgcc aatcatctgc 3425341 cgagtatgca gatgtccttt tctctgtttc ttctgcgatt tcctttccat acagctttct 3425401 gacttcatca gcgtatgtct gctggtgctc ttcaatgtct ttcatgctta atccggcaaa 3425461 taaatccctc ttattcatcg tttcccctcc atcaacggac aaaagcgtcc tgtcaattgt 3425521 ttgaatcatc tcatccattc tttgtttttt cttcatcaat atctcctttt gcgactgaag 3425581 tgccgctttc cggtcaaaat tcggatgatc cagcatctct ttaatctcat ccagacgaaa 3425641 cccgatttcc ttgaaaaata aaatctgttg cagtctttcc aggtctgcgt cactgtacaa 3425701 acgataccca gcatcagtaa gcgctgaagg attcagaagc tcaatattgt catagtgatg 3425761 aagcgtccga atgctaacgc ctgatatctc cgccacttgt ttaacttgat atttcataca 3425821 taacacctcc tcttttttat cgtaaacaat cacgcaacgt tagggtcaat ccccaaaatg 3425881 ttattttcta tatacaaaac ttctcacaaa tagtgtataa aagaaaagtg agtatttttt 3425941 tgtaaagggg agccagtata catgaatcct gaaacaatga acaaaaccct catcagcatt 3426001 tcgaaatggg gaaaagctac aggcatttta tttattatta tgggcgcaat taccgcgctt 3426061 tcaggcgcgt tcttttttct aatcggtgcc gtgccaggcg tactgcaaat tatttccggt 3426121 atctttttga tgaggtcagc tagggaagca ggccaaatgg ctgaacacaa tagcggacag 3426181 tctgaagact taatgctgga gaattacgcg aaattcgtaa agatgcaagg gatttatttg 3426241 atcgtaagca ttgctgtatc cattcttgcg attatcgcct tcttcatctt tttaatgctt 3426301 gggattgctg acggcctttt cagcgatacg tacagcactt attaatgaga aaaacccgga 3426361 gctggctccg ggttttttat tattccgctt cgcttaccac tgtgaagcgt tcatttttgt 3426421 gttcgggatg ttcaagctcg tccaacacgg caatggcata atctgcatag ctgatatagc 3426481 tgtctccttt tgcatttacg atgacattgt cttttccttt ttggtaagag ccagtccgtt 3426541 ttcctgctgg atcaaaaaat gccgcaggac tgaggaacgt ccaggaaatg gagtctgtct 3426601 gctgcaaatc tttcaggttc tcgccttgat ttgatgcagt tggcaaatat tctttcggaa 3426661 attccggcgt atccattaaa cgggttgttt tggcttcatc aacaaacagg cttcccgctc 3426721 cgccaacaac aagcaatctt gtgtgcttcg cgtcctttaa aatgctgatg agtgctcttc 3426781 ctgcttcaac atgaagatgt tcttggccgg gtgctgctcc aaaagcgttt acgaccgcgt 3426841 cgaaaggctt gatgtcttcc gcagtcagtt caaacacatc tttttccaaa atcgctacgt 3426901 cttgctcctg cacttttgaa gcgtttctga cgatggctgt cacttcatgg cctctttttt 3426961 tcgcttcttt caaaatctcg tttcccgctt tcccgcttgc gcctataata ccaattttca 3427021 tttttcattt cctccttatt tgtaacaatt ttagttacat gttagcggtg agaagtcatc 3427081 ccttttgatt aaaagagatg attcataaca tcttttaatg acttgcttgc cagttcattt 3427141 tccatcgctc tttgcacact ttcaaacgtt tcatccagag cgttctgaat ttttttccct 3427201 accggacatt tcggattcgg gttttcatga accgcaaaga gttcttcttg cttttggaca 3427261 gcccggtaca cttctaaaag agaaatatca gcaggatctt ttttgaggct tgcacccggc 3427321 accccggcgc gtgatgtgag aatatcagct tttttcagca ggctgatcat tcttcgcaca 3427381 actaccggat tcgtgttgac actgtctgca atgatttctg aagatgtttt ttcatccatc 3427441 gagatgaggg ataaaatatg aatggcaaca gcaagacggc tgttaatcat gttttttcac 3427501 caccgttgta actataatag ttacatttga ttcgtttgtc aacatctaat atacactaaa 3427561 tacatgggtt ttgtgcaccg tttttagtca atagaacggc cggatgcact ccggccgcgt 3427621 cttatcaaaa taagaaatat ctttgtccaa gtgggacata atcgacaggc tggcaagaca 3427681 attcctcccc gtcagcaaag acctgatagg tttttggatc aatctcaatc ttcggcaaag 3427741 ccgaattcag cttcatatcc agcttgctca gctttctgat atttttgact ggagaaatcc 3427801 ttttttccag ccctaagctt tccgccacac cacgctctat gcttgcctga gacataaatg 3427861 taatcgaggt tgagcggttg gcttttccgt aagacgcata catttggcgc atgaaaaccg 3427921 gttcaggagt cgggatggac gcgttcggat ctcccatttg cgcacgtgca atcatgccgc 3427981 cctttaagac cagttccggt ttcacgccga aaaataccgg gtcccacaga acgagatcag 3428041 caagcttccc tttttccacc gagccgacct catggctgag cccgtgcgta attgccggat 3428101 taatcgtgta tttggcaatg taccgttttg cgcgcacatt gtcattcccg ttttcaccgg 3428161 caagagcgcc gcgctgtttt ttcattttat cggctacctg ccatgttcgg atgatcactt 3428221 caccgacccg ccccatcgct tgggaatccg atgatgtcat gctgatcgca cctatatcat 3428281 ggagaatatc ctccgcggca atcgtcgccg ccctgattct ggaatggctg aatgccacat 3428341 cttcaggcac tttcgcatct aaatggtggc agaccatcat catgtcaaga tgctcatcca 3428401 tcgtattaac ggtataagga atggttggcg ttgtagatga cggcagaatg ttcgcgtaag 3428461 aggcgagctt cataatatcc ggagcgtgac cgccgcctgc cccttcaatg tgataagtat 3428521 gaataacccg gtccccgatc gcgtcgagcg tgttttccaa aaagcccgct tcgttaatcg 3428581 tatcggtatg gatggcaact tgaatatcag cctcgtccac gacttccata cacgttttaa 3428641 tggcgcttgg cgtcgttccc cagtcttcat ggagcttaag accgatggcg cctgcttcca 3428701 cctgctcgat cagcggcgct ttatcggatg cattcccttt tcctaagaag ccgacattga 3428761 tcggaaactc ctcggccgct tccagcatcc tcgccatata ccacgccccg gacgtacatg 3428821 ttgtcgcttt gcttcctgta gcgggtcctg ttccgcctcc caaaagggtc gtcacacctg 3428881 aagaaagcgc aacttccatc tgctgaggac aaataaaatg aatgtgcgtg tccactcccc 3428941 cggctgttaa aattttgcct tcaccggaaa tcacctctgt ccccgctccg atgaccatgt 3429001 gcggatcgac tccatccatg atatcaggat ttccgctttt tccgacaccg acaatccggc 3429061 cgtctttcac accgacatcc gctttgacaa tgcctgtgta atccaatagc acgacgttgg 3429121 tgataaccaa atccaaagcg ccgtccttcc ctgtgattct gccgttttgg cccatgccgt 3429181 ctcggatagt ttttccgccg ccaaagatca tttcttcacc gtatactgtg aaatcctttt 3429241 cgacttcgat ccataaatcc gtgtcgccca atctgatttt atcgcccgtt gtcgggccaa 3429301 acagttccgc atattcctcc cgtgacattt tcatcggatt acaccctcca tccagccggc 3429361 ttgttttaag ttggccaacg ttttttcttt gccgcgttca tcgataaacg tgtcggccat 3429421 tccgttcagc cctctaattg tcttgcgtcc tctgatttcc actagtgaga ccgttttctg 3429481 ctctcccggc tcaaaacgga ccgacgtgcc tgatggaaca tcaagacgca tgccgatcgc 3429541 cagctcacgg tcaaataata aagccccgtt ggcctccgca aaatgaaaat gcgaaccgac 3429601 ttgaatggag cgtgatccgg tgttttttac cgttacctcc cgtatctcac ggccttcatt 3429661 aatcgtaatg gttccctcag caatttgaaa tgctcccggc ttcatgactt cacctccgca 3429721 gaaattggct gatgtaccgt aacaagcttt acaccatccg gaaatgtggc ctccacctga 3429781 atgctgtcca gcatctcagg cacaccctcc atcacatctt tttccgttaa tacatggcgg 3429841 ccggcttcca tcagctctgc tactcccttc ccatcacgtg cgccttccat aataaagcag 3429901 gtgatataag cagcagcctc aggatagttc agcagaacgc cccgcgcctt tcgctgtttg 3429961 gctaattccc ccgctgcaaa aatgagcaat ttctcttgtt caactggtgt cagtttcatc 3430021 tgtagtcctc cttcttttgt catataaagc agatgcggct actacgaatt tgcggaacag 3430081 tcaggcggga catcacctcc ctttcttcga gaatgggggt catacggtaa gatgcctttc 3430141 aaagcggcat gccgtttctt catcagcctt gccatggtca acaaccgttc ccctgtcgat 3430201 cacggaaaga tcagattaac gcgttttcca gactgcgctc gactaagata acaaatgtct 3430261 ttttttctgg aaatttctat aataacttgt ctgactagtt cgacaattaa aatctgaatt 3430321 ccttccaatt gtttattaag taaaatattt ttcagattta ccatcagcgc tctggtgatt 3430381 gcaagctgct gctgttgacc gccttttcgt tttgaacaaa cgtttgatta aaacaaatag 3430441 ccccctctgt ttagccggag tcggcctaat acagcgacaa tctgccccgg gcgaagctaa 3430501 ggctgtgcaa aaccatcgat tgatcataac cagacgttac attcctgatg gcagcccgtt 3430561 gttttgctcc gcaaccggaa gcatggcatg gaggccagtc tgaggcgccg acctccacga 3430621 taccgagaac ccgactattg ccattaactc cgcatcatgg acggtcactt cgctgatcgc 3430681 caccgttcct cttaatgagt gaagaattcc ggccttcact gaatccccgc ttgtgtcgat 3430741 atcaactgtt ttctcgcact cccgtggctt ccgacacttt cttcggtgca gtacattccg 3430801 tcatcaaaac ccctttgttt gatttcttca aatgatgtta taaaagttta caacttatgt 3430861 catcattata tagaagaggc ctattaattc aaagaatatt taaaaaattt agttaccttg 3430921 accaaatcag cttctttttt tgttatattt attcacatca gaaaaagcga aaaaaaaaga 3430981 caagaaacat ttcgtttcct gcctcttccg tacgattaat ctttatctga aaatttatcc 3431041 ttggctttcc cgatatcctt ttggatttcg ccttttgcct tatctttttt gccttcagcc 3431101 tgcatgtccg ttctgtcagc catatctccg actttatcct tcacttctcc tttggcttta 3431161 ttgaagccgc ccttcatttt gtcttttaca ctatcgttac ccatgttaat tctcccctct 3431221 caattatgtg tgtacttgtt aacttcccga tctgagaggc aataaacatt ctaatgttat 3431281 ttatcgattt cgtagcgctc tccgtaacgg agcaccttgt atatcgccag cccgtctgat 3431341 gactttttct ccgaatatcg gaccggcagc agggcaaaaa acacataata cgtagaaaaa 3431401 tagacaaact gatagaaaaa cacattcggc tttaatacac tgtgtataat cagcagattg 3431461 attgcaaaaa tcgtgatgag gttaaacaag cagccccctg catacacgag tgcatttgag 3431521 aatcgattgt caattttcaa ctccccgtac cggcaaaaag aatcgataaa ataaatcgtt 3431581 ctgaaccgta tgggtccaat tttaagcagc gtttttccca tgcctatatc caacgatccc 3431641 tttccgccaa aaataaaagc cataaagctg tgccctgaaa catgtataat ctgtacaagc 3431701 ggcagaacaa tgaggaaaga ccacagaaac ttcaccatat cattaaaacc aaacattgaa 3431761 ttccccctca catgcatatc tgcatcccaa aacggctttt gttcaaaaaa cagtgctgta 3431821 gcgatttttc ctgttctccc cggaaataaa cgttccgatg ctcccctttt tttgcataaa 3431881 aaaaaaccat ctgccagcag atggttttgt ctcatacttc atataaacaa tcgttccttt 3431941 gaatcatctc tctcatgctg accgcttttt cataaaaata caccgcttct ttatattgtt 3432001 cgcgatgact gaaataagag gcagcatcta aagcaaattc ttcaatatat acatacaggc 3432061 ccttttcttc catataatca aatacttctt gaatcatatt caaattgaca gattccacat 3432121 ataatgcctg cagaaattta tattttgcca gactgaagaa gtcgtttcgt ttttgggcaa 3432181 tggcaatccc tttttcatag taccgtatcg cggcttcgct atcttgtttt ttgaaaagaa 3432241 cgcgagtcag gctgaagagc gcttttggaa gctgttccag ctgataatcc tcgaagacag 3432301 gaagcgcttt ttcaaagtat tcggcggcct gatccagctc ccccttgtca tcatagcaat 3432361 taccaatatt ataaagggct gatccgatca aacggggctg tccttccaat aaagcaaggc 3432421 gatacgcgtc atctaaatgt tcaagcgctt tttcataatt tctgtagtca atgtagtttc 3432481 ctgatatgac gaaatggcat tgaattcttc tgactctgta aaaatcgtga gccttatacg 3432541 tctccagcgc ctgtacggca tggttcatgg aaaagtgcgt ctgcttcata atataaaaga 3432601 cttccgccac tttaaaatga aattccgctc tttcaatttc atcttctaca aacgcaagca 3432661 tcttctcagc tttccgataa aaggatatag ccgagatgta attgttctgt tcaaattcgt 3432721 acattcctct aaacaagtga aaataatact cagataatcc ggagatgctg tcctgattgc 3432781 tttccagcgt tttgatcaat tcacgatatt gaagctgaga ttcctcgtgc aggtcaggct 3432841 ttacataatc cagcataatt tggtgccggt agctgatcag ctgataatac aggagaagca 3432901 gctgatcctc ttccatctgt tcgatatcta gatcaatttc ttctttcagt tttacggcat 3432961 cagccacttg aaatgctaaa atgtgcttat accacttatt gattttcact cctacttgag 3433021 atgacgggat ctcgtacgcg gccatgcccc tccaaccctt tctattttct aattggttat 3433081 attttatcat aatgtatggc tttggaatta aattttctta caatgattcc ttctttatgc 3433141 ctatccttat atatttcggt ttttctacgt attttttgca ctcggattct aataaaaaag 3433201 cttaccggac agtgccgata agcttttgac ttcaaattaa ccgccaatat aagacatttc 3433261 cactttcttt ttgccagatg cttttgatag cgtacgatcg actgaatact gatcgatccg 3433321 atttttccat actgtcccga tcatttctga tagttcgtca tcacttaatt cctggcgaac 3433381 cggagctctg aggtcaaatc cgcttgaagc gaataagcag gtaaacagct ctcctctcgc 3433441 agaaagacgg gctctgttgc aagatccgca gaatgcatca gatacagatg atatgacgcc 3433501 aatttctccg gagccgtcca agtagcggaa tctggaagcc acttcgccta tataattagg 3433561 cgctatcggc tcaaccggca tgtgtttatt gatcaaatct atgatttccg cctttgtcat 3433621 gacgtctttc ttttcccatt ggttggtgtt gcctacgtcc ataaattcaa tgaatctcag 3433681 gatatgccct ttttctttaa aataacgggc cataggcagt atatcttttt cattgacgcc 3433741 cttttgaacg accatattga ttttaacacc gagccccgct tgcttcgccg cttcaatgcc 3433801 ttccagcacc ttgctgacag aaacaccgcg cccgtttatc ttcttaaaac gctcgtcttc 3433861 taaagaatca aggctgatcg taaccctttt cagcccagcc tccttgagcc tcttagcata 3433921 aacaggcagc agtgatccgt ttgtcgtcat cgcgatgtca cgaatacccg gtatgcgggc 3433981 cagttttttg attaattccg gcatatcctt tctcatgagg ggctctccgc cggtcaagcg 3434041 gattttttca acgccaaatc ttgtgacaaa caatgtcgca agccgttcca gctcctcaaa 3434101 tgaaagcagc tcctctttct ttaaaaaagg ataatccggg ccgaataatt cggcgggcat 3434161 acagtacgtg catcggaagt tgcagcggtc tgtaacagaa atgcgaaggt ctctcagcgg 3434221 tctgtttctt ttatccaaca tctgacgcga ctctgtaatc atagctacag ccccttccta 3434281 ctccctgatt ctctcagggt gtgtatatac attaaatgat ccgtttctga caaatccaat 3434341 cgctgtgata ttcaattctt cagccatttg aatcgcaagc tccgtcgggg ccgatttgga 3434401 aatgacaatc gacacgccga ttttggccgc ttttaacagg acctctgatg agattctgcc 3434461 gctgaacaca atcagtttgt cgcgtacgga catcccgttt agaaggcagt gtccgtatag 3434521 tttatcaagt gcgttgtgcc gaccgatatc tgtgcgcatc aacagaagct tctctgtgtc 3434581 gcaaagcgcc gcattatgga cgcctcccgt atcctgaaac gtcccgctcc cttgctgcat 3434641 gtctttcata agcgccagac atgcctcagg cgatatcttg atttggctga cagccgtctt 3434701 ggctgttttg acatcctgct gaaaataaaa atgacggccc tttccgcagc atgagccgat 3434761 cacccgtttc gtataatcct tttgatccaa tgtctcaggg tgaacgaggt cgacatatac 3434821 aaaaccgaga ctttcatcta ttgtaaacct tttaatttct ttttgaaatc gtataacacc 3434881 ctctgatgcg agaaatccga tgacaagctc ttcgatatgc tcaggcgtac aaacgagcgt 3434941 cacaaattca ctgccattca gtatcactgt caaagggaat tccgtcacca tccggtcttc 3435001 tactttgctt atttcccctt gttcatagcg ccatacatcc ctgaccgcag ttactttatc 3435061 gttcaatgtc tcttcccctc cgcaatgttc ctgcctttat attttttcac actcctcgga 3435121 ttttgtcgaa ttctgagaca caaaaagagc cctctatata aagggctttt acaggatgtg 3435181 atgacggcgg tgtttaggca ggacgcctaa gcatttagcc gccgttcctt ttataacacg 3435241 tgagcaccaa tgtgcattga caacgaacgc ggggtttgtc gacacgctga gacacctctg 3435301 tataaaggac tctatgtttg attatgctga ttctttttca gaaccgtaaa cagcacaata 3435361 gctgcgatca aggtgagaat gctgacaaaa aagaaggctg ccagttttag aagaacacca 3435421 agcaatataa atgcaacggt ggctataaga aaaatcattc cgaataattt catatgttca 3435481 accccttttt agggtatcat tcccgcccaa actgttttta aaccaataaa aaaggcgcct 3435541 gggggagcgc ctgatcttta ggttccttac tcagtaaatt tttgtgcttc tttttcccaa 3435601 gcctgttcga actcatccgc actgttcgct gaaatatatt ctccgccgcc agcgacagct 3435661 gcttgtttca tctcttcatt acccttgaca tcaaagttga agccaatgat gtttacaatc 3435721 gtatccacat ttgatgcacg gagcttttcg atttccgccg cagggtctcc gccgcacgtt 3435781 tcttcaccgt cagtgattaa atacaccacg tttttcccgt ctgcgtcaaa tgcttcaaat 3435841 tcttttcttg tgtctgcaag tgctttggca atcggtgtcc atccagtcgg cttgagctca 3435901 ctcaatgaat tgtcaaacag agacccttca tatggatgaa ggccgtaaat ggtttccgtc 3435961 gtactgcacg aaagggcttt accggacagt ttattgttcc ctgcatgccc gaaaacgcga 3436021 agcataagat ttgtatcctt tggaagaagt tcggcaaaag attttactga ttttttggca 3436081 atgtctattt tgcgctctcc tcctgttttt tgaaccatgc ttccgcttcc gtcaaacaaa 3436141 acagctacat ttgtatcagc ctgtttctca gcggcaaaag acggggaggc aatggaaaca 3436201 gtcaacaatc caatgatacc ggcagccagc aattttttca tatgattact tcctttcttt 3436261 ttcatatttt ccaactatat gttggattct tctttatgct agaatacgaa aatgcaaaaa 3436321 gatataggac atgctgcctt ttgtgctgct ttcacgatct gtccaaaatc gcttgaaatg 3436381 ccgttcattt ttagccattt ccgcccagaa agcataaaca gcttgtgtga tcattcattc 3436441 ttttttcgcc ttgattatga cagaaaaacg gaaatctgct actatgctac aggcagacag 3436501 ctaattagtt ttgaagtttt tgttacatac aaaaagaggc tgaccatcac cagcctcttt 3436561 tttcttattt agataacatt agtgattgct gagtgaaaat tttctcaaca tctttttggg 3436621 tataagccgg gaagtattca ccgccgccta ctttcgcaat tgcgttcagc tggcctttgt 3436681 atccctcttt ataatcaaag ccgatcacat taacagtgat attgtctttt tgcagttcct 3436741 ttgctgtttt aatcgggttt cctccgcacg tttcctcacc gtctgtcaac agatacacca 3436801 ctttttcccc ttttgcatca agctggtcaa aagaagattt cgcctcgttc agcgctttgg 3436861 caattggcgt ccagccagtc ggcccaattg tattgagaga attgaggaag ctttgctcgt 3436921 taaagctttg gaagccgtat acgttgcgaa tggcttcaca tgactgaact tttccggaat 3436981 ttttattgtt tccttcagag ccaaacacgc tcattttcac ctgagttcct tctggcaatg 3437041 agctcgcaaa ctttgaaatt tcttttttgg ctgaattaaa tttagataca ccatctattc 3437101 ttttcgccat acttccgctg gcatcaagca agaccgccac gttcgccggc gctttagcct 3437161 ccgtttctgt cttttcagct gcaaaagcag gtgaagttaa tccaaaaagc aatcctgtca 3437221 tcatgatcag tgaaaatctt ttcttcatgt tcgtacccct ttaccaattt gtttctgcgt 3437281 gcagatgttc aacgctgaac ataatctatc gtaatcaaca aaaaccgaga aataaatagg 3437341 gcgggcttcc ccattgctgt tgtttacttt tgcatagaaa cctatgtttt tattagtgat 3437401 ttccacctaa cgcccctatg aaaagagaag attgtccgcc tttcggcttt cgttatatga 3437461 gtctgtcgaa gtctgtcgac aaatgtggat gactttacca caatctcaaa gcctgaaatc 3437521 aggaaaaaag gactgatcct taaagacggt cagaagctcc tctaaaccgt ttcagctact 3437581 cttagataaa agatattcag gaacagaaaa agacgcccaa tgagcgtctt tttctacttt 3437641 ttcgccatat atttattcaa aaacgcatct gcctcagaaa tttgtgtgcc ttggtaatag 3437701 tactttacaa tgtcatcaac cgttttgcct tctttggcca taaaattcgc tccgtattgg 3437761 ctcatcccca caccgtggcc aaatcctctc gtcgtgactg taattgtgtc tccatttcgc 3437821 ttccattcaa aatcggcgga gttgagaccc aacttttcac gtatgtctct tcctttcagc 3437881 gtcttgccgt taatgacggc agttgcgacc tggtggcccg gtgtctcgcc ggtaatcttc 3437941 cctactgcgc tagatccatc cagcttgacg ccaagctttt gctgaaattc tgccgctgta 3438001 aaggttttcg ttgccttata tttcggagac tttttatccc atgggctttt gacgcttttt 3438061 aaatatggga tagcacttgt ccaataagct tctgcattct ctgtgtagcc gttgcttgtg 3438121 gagaaaaagg atgcttcaat cggctggttg ttgtacgtta agattttgcc ttgcgtactg 3438181 gctaccgcat ctgtgatttt cttcagtttt gtctcatagc ttgtgcccca ctgttttttc 3438241 agctccgctt tgcttttata cacctggaac atctgtgtat catccaccag tgagccttta 3438301 ggagcttcta ccgctgaatt tgacaccatc agtctgacaa taaatgttct ggcggcaagc 3438361 gcctgggctt tcagcgcttc aggtttaaag gttgccggca tttcggaggc gacgactcca 3438421 atcacatact cttcaagcgg aatgttttct acggattgat ttgcggttcg atagacggga 3438481 atagaaacag gtgatgcttt caatgtttct gctcctttcg atgctggttt cgtgctgact 3438541 gctgtctttt ctgattctac gctggccccc gcttccttat tatgctggaa tggtataacc 3438601 aagagtgtgg gaaccaagag aatcaatgca catagtacgg atagtgtgat tgcgaattgt 3438661 ttcatattca gctgcctcct gctcgggatt cgactctagt ctagtctatg ggcagggaca 3438721 agctaatatg actctcgttt tggacagaaa ctttatttgt catttacgta ttcttttttg 3438781 ctattttgcg cataatgatg ataatacaca aaaaataaaa aaccagtatg ccagagtgac 3438841 atactgattt tcaagtaagt ttatgcattt aagtcagaaa cgacttcttt attctcttgc 3438901 tcagaagcag actcatcatt tacacgttcg atgtctgcgc ccagagcggc aagcttctga 3438961 tggaaatcaa cgtaaccgcg gtctaagtgc ttcaattcag taacacgtgt gtgaccttca 3439021 gccactaacc ccgcaagaat cagcgctgca cctgcacgca aatcagtcgc tgcaacttca 3439081 gctccctgaa gctgtacagg accgttaatg atgacagaac gtccttcaat cttgatatca 3439141 ccattcatac ggcggaattc ttccgcatgc ataaaacggt tttcaaaaac ggtttctgta 3439201 atcatgcttg tgccgcttgc acgaagcaga agcgccatca tttgtgactg catatcagtc 3439261 gggaagcccg ggtgaggcat tgttttgatg tcaatcggtt taagctcttt cgggccgatg 3439321 acacgcagac cttcaccttc atccttaatt gttacaccca tctcttccat ttttgcaatt 3439381 aaagaggtga ggtgctcagg aaccgctcct tttactaata cgtttccttc agtgattgca 3439441 gcagcaacca taaatgtgcc cgcttcaata cggtcaggaa taatatggtg ttttacgccg 3439501 tgaagctttt cgactccttc aattttgatg gtgccggtgc cagctccgcg gatttttccg 3439561 cccatgccgt tgatatagtt tgctaaatca acgatttcgg gttcttttgc cacgttttcc 3439621 agcgttgttg ttccttcagc tagagcggct gccataatca ggttctctgt agctcctaca 3439681 cttgggaagt ccagataaat ttttgcgcct tgcagtcggc cttttacttc agcttcaatg 3439741 aagccattac cgactttgat ttctgcgccc attgcttcaa aaccttttaa atgctgatca 3439801 atcggtctgg aaccaattgc gcatccgccc ggaagtgcaa ctcttgcatg acctgtacgc 3439861 gcaagaagcg gccccatgac aagcacagac gcacgcattt tacgaacata ttcaaaaggt 3439921 gcttcagttt gcaaagcgta tgaagcattt acagtcactt cattattttc aaaatgcaca 3439981 tctgctccta aatgacgcaa cacttcgtta attgtatata catcggagag cgtaggtaca 3440041 tcacaaatta cgcttttttc ttcacttgct aataaagatg cagcgataac aggtaaaacg 3440101 gcatttttag cgccttcaac tttgactgtg ccgtttaact tctgaccgcc gcggacgatg 3440161 attttttcca aggtattccc ctccgcgtcc ctaaattctc tatattaata ttcagtcgta 3440221 acgattggtg tgccaaccgt aacggtatgt tttccgccca ttcctgcact tctaagtgca 3440281 atttgcaaat tcattttatg tttcgaggtc ataatgtact cttcccactc atctgtaaac 3440341 gcagaaatag aaacgaaatt tggctcaact acatgttcta ctgatcttgc ttgaaattca 3440401 tttaataact gatttgcttt tttttgcaaa acaatattca tattatcatc taagtgacca 3440461 tttagacaag taaaaataac tactttttct tggaatatcc caagtgtctc ccgttcaaac 3440521 tgttcatatg tatcattcca gctatccggt gtctctagac tcatttgctc atataataaa 3440581 tacgaagttg gattgtgttt tttgagggtt gtgacaagct gcagtctaaa agaagtacga 3440641 ttttttttgt cagtatatgt gccaattgcc tttatcattt tatcttcccg tgcaatcacc 3440701 caatcatatt gacgatactc ttgttttaaa cgttgcactt tttgataaaa ttctttttcg 3440761 gtcagtgaca agttttgttt tgcatgcaat gtccacttat ctattgacac atcttgacgt 3440821 tccatcccct ctgccatctg tgctaacggc gttaattcac tcgcatgaat ggtatggaaa 3440881 acagcaatga cgaagcttaa catgacggaa atgataatag cgtggcttac ttgttttttc 3440941 ttcatgttca tctctccccc ttatccccag ttttaccgga ggcaagaggc gccatacgta 3441001 aaaatcttcg tcaaaactcg agctattcgc ttcaacccgc ttctcccaac catttaataa 3441061 tgttcaaaac ctattaaaat agatagggaa gctgctgtga ataattgagg taatctaaaa 3441121 agaaattggc aacggccgtt ccaatggcga ttgtcagcaa aatcatcagg agtcttgcct 3441181 gcacgacttt gccttttttg attaacggat ctatattgac ggcttgcaac gcccaccaag 3441241 tcactgctat aaaaatcagg tgaacgacaa tgccgattgc agcctgctgt cccaatacac 3441301 tcatctatta cactcctttc tctgcgttca taccctttct tattatataa gaagcacaga 3441361 taaagatgat acattttata cagaacggaa taatcagcca aatctagggc taatccccgc 3441421 ttaaagtgcg attcttttac atggtatact ttattggaaa ggagctggca aatgtgaatc 3441481 attctttttt tcagcctgaa aagcaatatg gtgaggacct gccaattttt gatcaggaat 3441541 gggaagcaat tgcattctat tatgattata gacagtcaca gattgaagaa ctgaatgaat 3441601 tgtgtcagtt ttttaacatt tctcttacct atacgagaga aagccttgaa gagcttgaaa 3441661 acctctattt tcaaagtata caagaacttt tgcttgctga ttggaatctt cctattgaag 3441721 aattcgagaa aatgatcagt gtttatctta tagattgtgt gattgcccgc catgaagatg 3441781 ctgaatgggt tgtaaaacct tatccctata aagacggcgc ttatacactt ggctttagaa 3441841 gacatcgcaa atcgtggcat acaatgaatg cctgtgatgg tttatacctg cgtccaaaag 3441901 aggatcgccc gttgctgtcg ctgtttgatt ctcttgtgcg ttcataaaaa aatccttctc 3441961 ataaagagaa ggattttttc ttatttccct gctacatcca atctgttcaa agcccgctgt 3442021 aacgcaagct cagcccgacg aatgtcagta tcatctgatt gagaattcaa acgctcctgc 3442081 gcccgctggc gtgcagcttc agcgcgctct ttatcgatgc cttccgctgt ctcggcagcc 3442141 tgggcaagga tggtgacatg atcaggacgg acttctacaa aaccgccgct gacggcaacc 3442201 atttcagtct gcccgtcttt tttcagacgg acagcgccga ttttaagagg agccacggtt 3442261 ggaatatggc ctggcaaaat accgagatcg ccgctttcgg ctctcacact caccatttcg 3442321 atatccgcat cgtatactgg gccgtcggga gtaacgatat tgactttaac ggtcttcatg 3442381 cttttaccct cctaggacca gattaaactt ctacacccat ttcttttgct ttctcaacaa 3442441 cttcttcgat acggcctaca agacggaatg catcttctgg aagatggtca tatttaccgg 3442501 ctaagatttc tttgaagcct tgtaccgtct cttttacagg cacgtaagaa cctttttgtc 3442561 cagtgaactg ttcagccacg tggaagttct gagaaaggaa gaactggata cgacgtgcgc 3442621 ggtgaacgac aagtttgtct tcctcgccta attcatccat accgagaatc gcaatgatat 3442681 cctgaagctc tttgtaacgc tgaagcgttg actgtacttc acgcgcaacc gcatagtgct 3442741 cttctccaac aatttcagga gcaagggcgc gtgatgtaga tgccaacgga tcaaccgcag 3442801 ggtaaatacc catttcagtt aatttacgct caaggtttgt tgtcgcatcc aagtgagcga 3442861 acgttgtcgc cggcgccggg tcagtgtagt catcggcagg cacgtagatc gcctggatag 3442921 atgtaactga tccaacgttc gtagacgtga tacgctcttg gagctgaccc atctcagttg 3442981 caagcgtcgg ctgataacca accgctgaag gcatacggcc aagaagggct gaaacctctg 3443041 aacccgcttg tgtgaaacgg aaaatgttat cgatgaagaa cagtacgtcc tgtccttgta 3443101 catcacggaa gtgctcagcc attgtaaggc ctgtcaaagc aacacgcata cgtgcgcccg 3443161 gcggctcgtt catttgtccg aataccatgg ctgttttgtt gattacgcca gagtcactca 3443221 tttcgtagaa aaggtcgttc ccttcacgag tacgctctcc tacgccggcg aatacagaga 3443281 taccgccgtg ctcttgcgcg atgttgttga ttaattcctg gattaatacg gttttaccta 3443341 caccggcacc accgaacaat ccgattttac cgcccttaat gtaaggagca agcaaatcaa 3443401 caactttaat acctgtttca agaatttcaa cttctgttga aagctgatcg aatgaaggcg 3443461 cctgtctgtg aatcggatcc tttttcgcat ccgcaggaac cggctcattc aaatcaatat 3443521 tttctccgag aacgttaaat acacgtccaa gtgttacatc accaaccggt actgagattg 3443581 gcgctcctgt atctacagct tccataccgc gctgaacacc atctgtagat gccattgcga 3443641 ttgtacggac tgtatcatca cctaaatgaa gagcgacctc aagcgttaaa tcaataccta 3443701 cttcgttttc acttgcagct ggctgtgaaa ttttaatcgc attataaatt tcaggcaagt 3443761 gaccgtcttc aaaacgcacg tcgacgaccg gtcctaatac ctggctaacg cgtcctttct 3443821 tcatcgctat ccctcctgac aaaatctttc tattctaaag cggctgctcc gccgacaatt 3443881 tccgtaattt cttgtgtgat ggctgcttgg cgagcgcggt tgtaagaaag cgaaagtgaa 3443941 tcgataagtt ccttcgcgtt gtctgtcgcg tttttcatcg ccgtcattct tgcagcgtgc 3444001 tcacttgctt tactgtcaag aagcgcaccg aagattaagc tttctgcata ttgaggaagc 3444061 aaaacctcca gaacctcctc ttcagatggt tcaaattcat aagacgccgt tctttttccg 3444121 ccgccgctgc ccaaatcaga taacggcaga agttttttct ccgttacttc ttgagtaatg 3444181 gcgctgacaa aatggttata aacaaggtgc aattcatcaa acgcaccgtc tataaacatt 3444241 tgaatcgttt gacgggcaag atctttaatt tctgtaaacg ttacttcatc tccaagtcct 3444301 gttaactcgg aaatgatcgg aatctcccgt ttcttaaaga aatcacggcc cactcttccg 3444361 atggcaatca ccgcatactc atccttagac tgatgacgtt cttgcatggc ctgataagca 3444421 ctccgtaaaa ccgaactgtt aaaagcgccg gcaagaccgc ggtcagacgt aatgacaagg 3444481 tatgccgttt ttttcacttc tctgctgaga agcatcgggt gcttcacgtt gccggaaact 3444541 cttccgacgt ttgacacaac ctcttggatt ttatccatat atggcacaaa tgattttgca 3444601 ttgttttcag cacgattcag cttagccgca gataccatct gcatggcttt tgtaatctga 3444661 cttgtttttt tcgttgacgt gatccttgac ttaatatcgc gtaatgaggc caaagatttc 3444721 accacctttt ctcttcatct gcgtaaaaag agagaaaaag agaacctttt tctctcatca 3444781 gcattcgagt tagttgcttg gtgcaaatgt gcgtttgaag ccttcgattg cagctttgaa 3444841 gtcttcatca gcaggaaggt ttcctgtttt cgcaattccg tcaagcaggt ctttatggtt 3444901 ttggtcaagg tacatgtagt actcttcttc aaaacgtctg atatccgcca caggaatatc 3444961 atcgagatat ccttttgtca gcgcataaag aatagctact tgcttttcaa ccggaagcgg 3445021 cttgttcaga tcctgcttca gcacttcaac tgtacgcgca ccgcggttca gttttgcctg 3445081 agtcgcttgg tcgaggtcag aaccgaattg agcgaatgct tccagctcac ggtatgacgc 3445141 aaggtcaaga cgcaaagtac ctgatacttt tttcatcgct ttgatttgcg ctgagccgcc 3445201 gacacgggat acagacaatc cggcattgat cgctggacgt acgcctgaga agaacaaatc 3445261 agattgcagg aagatctgtc cgtcggtgat ggaaatgacg ttcgtcggaa tataagcaga 3445321 gatatctccg gcttgtgttt ctacgaacgg cagagctgta attgatcctg cgcctttcgc 3445381 gtcgctaagc tttgctgcac gctcaagcag acgggaatga agatagaata catccccagg 3445441 gaacgcttca cggcctggcg gacggcgaag aagcaaggac agctcacggt aagcggccgc 3445501 ttgtttagaa agatcatcgt atacaacaag aacgtgcttg ccgttgtaca taaattcttc 3445561 tgccattgta accccagcat acggtgccag gtacagaagc ggtgccggct gtgacgcaga 3445621 cgccgttaca acaattgtat aatcaagcgc gccgtgttta cgcaatgttt ctactacgcc 3445681 gcggactgtt gattcttttt ggccgatcgc aacatataca cagatcatgt cttggtcttt 3445741 ttggttcagg atcgcatcga tcgcaacaga tgttttacct gtttgacggt caccgatgat 3445801 cagctcacgc tggccgcggc cgattggaat cagtgcatcg atcgctttga taccggtttg 3445861 aagcggttca tgaacggatt tacggtccat aacgcctggt gcagggcttt cgatcggacg 3445921 agttttgctt gtcagaatcg ggcctagtcc gtcaaccggc tggcctagcg ggtttacaat 3445981 acggccgatt aactcttcac caacaggaac ctccatgatg cggcctgttc tttttacttc 3446041 gtctccctca cggatctcac tgaaaggtcc taagatgacg atacctacgt ttgattcctc 3446101 aaggttttga gccataccca aaacaccgtt tgaaaattcg acaagttcac cggccataca 3446161 gttgtcaagg ccgtgcacac gtgcaatacc gtcaccgact tggatgactg tacctacgtc 3446221 ttgaacttca atatcagatt gataattttg tatttgctgt tttatcagcg tgctaatctc 3446281 ttcagctttg atgctcactt aggtttcacc ccttctatcg attttccccg gctaattgac 3446341 gttcaatgcg ctgaagcttc ccgcttacgc tgccgtcata aatccggttt ccaatgcgga 3446401 ctttaatacc gcctattaaa tccgtctgca cttcatttct gattctcagt gaagcgactc 3446461 cggctttttt tgcaaacact tgtgataatg gtaacatttc tgcatccgtc agcggtttca 3446521 ctgaatatac gattgcgtct tctgtttgac gggccacatt tgcgagtttg ataaactcat 3446581 ctgtgagctc agggacaatc gcggcacgat ggcggtcaat caaaagaaaa atcgtattga 3446641 gtacggactg tgacaaagag ccaaatgcat tttgaatcag ctcttttttc ttcgcagccg 3446701 gcaccttcgg atggttcaac acatcattaa gcgctttttc attttgaaat acttgtttta 3446761 caacaattag ctcttcttct acttgattca gctgagcgga ctcattggct atatcaaaaa 3446821 gagctgatgc atatcgttta gagacagctg atccactcat cggctttctc ctacctcttt 3446881 aagatagtcc tggatcaatt tctcttgcgc ttgttcatcc agttcttttt cgatcacttt 3446941 cgacgcaatc atgacagaaa gagacgctac ttgctcacgg agagcagaaa ccgcctgttc 3447001 cttttccttc acgatttcag ttcttgctgc ttctttcaga cgttcagatt ctgcacgtgc 3447061 agcctgaata atctcttctt tttgcttctc tcccagtttc tttgcgtttt cgataagagt 3447121 ttgggattcc tgtcttgctt cttttaaaag aacgcgctgc tcttcaatca gctgctgcgc 3447181 ttctttattt ttttcttcag cagacgtaat ttctccagcg atgtggtctt cacgctgttt 3447241 cattatgttt aatagcggcc ctaaagcgta tttcttcaga agcgctaata agattaacat 3447301 agctaacagt tggaacagga tatctccgcc gttaaacgac aatcctagtt caagtggtaa 3447361 ttgagacatc tactacggca actcccttct gcaggttttt ctttgctgat ccagcagccg 3447421 cacttgtctc ttttcagccg gcaaggcggg atgcttatca gacataaagc aatggcgaag 3447481 gttctcttgg aatgatcttc gccattttta gttcatataa ggcttttatg cttagccaaa 3447541 gaacgctaag aatgcgataa cgacagcgat aataggaagg gcttcaacta atgcgatacc 3447601 catgaacata agagttctca gttctttacc tgcttccggc tgacgggcaa tcccctctac 3447661 cgtacgtgaa acaatcaaac cgttaccaat acctgcacca agtgcgccta aaccaattgc 3447721 aatcgcagct gctattaaat tcatgaaaaa gttcctcctt taaaatgtta tccgtttgga 3447781 tataatgttt taatgatcat gactgatttt atgagacatg tacaccatcg tcagcattgt 3447841 aaagataaat gcctggatag caccaataaa taaactgaat gcttgccatg ccagcatcgg 3447901 cagaatggca ccgattgtac cgacaagacc gagagccacg ctttgcgaat aatggcttgt 3447961 tgctaatccc gcaagcaggc cgagaagaat ctcaccggcg aagatgttac catacagccg 3448021 caaacctaga gtcagcgtat tcgcaaactc ttcgatgatt ttcatcggga gcatgaatgg 3448081 aacaggtctt aaatagtctt tggaatattc cttgagccct ttcatcttca caccatagta 3448141 gtgggttaaa gcaacaacca tcacggctag cgttaatgta atggcaggat cggctgtcgg 3448201 agacttccac cagagctcat gtccgattgt aatagagaac ggcagcccca gcatattcga 3448261 cacaaatatg tacatcagca atgtgacacc aagtgccaag aagttagccc ctgtttttaa 3448321 atccattgta ctgccaataa tattgcggac gaaatcaaca atccattcca taaagttctg 3448381 ggcttttccg ggacggatcg aaagcgttct tgtcgtcaat atagcaatca ataaaacaat 3448441 cacactcgcc acagtaatca tcagaatgtt tgtcagatta aaagtaagac ctagaaattc 3448501 tatagttctg taaccatgat tcaaagggtt ttcacctctc ttccattgat gaacgtttaa 3448561 gctggataaa ggaatctatc ataatgacag ggtatattgt cattaatcca ataactgtac 3448621 ttgccatatg aaagtattcg ggatttttat aggcaacagc cacagcaaga atcgcattgc 3448681 accaccgcgc tgcgctcccg agagatcgta tggactttcc tttctctaca gctctgtcaa 3448741 aagcattcat tcttctgacg agcagtaaaa aattaaacaa actgaaaaca gttcccagaa 3448801 taaggcctaa aaaaacggtt ttatacgctg ttaaaccata acccagtaca tacactgcca 3448861 aaatgaacaa taaatatttg cgttgtctgc taaatgtaag cttgggatcg tccatcaatt 3448921 atctgtctcc tgatgaaaaa ataatgtata gcttggatac ggcaaaaatc agcggttaac 3448981 ccttagtaga agaccttttt tgaccggcaa aacgggcctg ttcgaaaaaa tcattcatcc 3449041 gcaagccttg cagggatgct gtttcattcg cttaaataaa tcctcataat acgggtttgc 3449101 tgagaggatt tacattgagg atgaggacta taatgaaagc tatgaaaacc ttctcataat 3449161 accctcgttt agcatacaat agcccctaac atgtgtcaat ctgtttaaag ttaaaaaact 3449221 ttttatactt tacgtctcca cagaatgttc acattttcac ctataattgt atacagattc 3449281 accgaatagc aaaaaactgg ataaaaaaat gaaaccccct tttggggatt tcatttttta 3449341 ttttgttcca aacatgcggt cacccgcatc tccgagacct ggaacaatat atcctttttc 3449401 atttaatttt tcatctagcg ccgcaatgta aatatcaacg tccgaatgat gcttctgcaa 3449461 ttcttccaca ccctccggcg ctgctacaag acacatgaaa cggatatttt tcgcaccgcg 3449521 ttttttaagg ctgtgaatgg cttcaactgc ggaaccgcct gtagcgagca tcgggtcaac 3449581 cacgatgaat tcacgctctt ccacatcaga aggaagcttg acatagtatt ccacgggttt 3449641 taaggtttct ggatcacggt aaaggccgac atgtcccact tttgccgcag gaatcagctt 3449701 taaaatgccg tcaaccattc ccaatcctgc tctgaggata ggaaccactc cgagtttttt 3449761 ccctgagatg actttcgatt tcgcagcctg aaccggtgta ttgatatcca cttcttccag 3449821 aggaagatcg cgggtaattt caaatgccat gagtgtagcc acttcatcta ctaactctct 3449881 aaaatccttc gtacctgtat tttcattccg tatatatgtc agcttgtgct gaattaaagg 3449941 atgatcaaat acataaacct ttcccatact gtgtttcagc tcctttttta ttgtcccatc 3450001 aacaattaca cacttctatt gattctacaa aaaaagacat tgagtttcaa gaacatcgtc 3450061 aaaaaacccg ccgggcataa gcccaagcgg gttttaggat cttaataatc taattcttta 3450121 tataaaggaa atttatcagt cagagcagct acacgctgtc ttgcttcttc aagttttcct 3450181 tcatcttcgt ggtttttcaa tgcaagcgca atgatagcac cgacttcttc taatgcgtct 3450241 ccgtcaaaac cgcggctggt tacagcagct gtaccaagac ggatgccgct tgttacgaaa 3450301 ggtttttcag gatcatatgg aatcgcgttt ttgttagacg taataccaat ttcatcaagt 3450361 acatgctccg caaccttacc agtcagtccg agcgaacgaa ggtcaacaag gataaggtgg 3450421 ttgtctgttc cgcctgaaac gagctggatg ccctctttcg ttaaggcttc agccagacgt 3450481 ttcgcgtttg aaatgacgtt ttgtgcatat gttttgaaat cgtcctgcaa tacttcaccg 3450541 aatgaaacag cttttgcggc aataacgtgc atcagagggc cgccttgaat tccagggaag 3450601 atcgatttat caattttctt gccaaactct tcacggcaaa ggatcatacc gccgcgagga 3450661 ccgcgaagtg ttttatgtgt tgttgttgta acgaaatcag cgtaaggaac cgggtttgga 3450721 tgaaggcctg ccgcaacaag tcctgcgata tgtgccatat ccaccatgaa gtaagcgccg 3450781 acttcatcag caatttcacg gaatttctta aagtcgattg tacgaggata cgcacttgct 3450841 cctgctacga taagcttcgg tttatgagcg agggcttttt cacgcacgtc atcgtaatca 3450901 atatattgag tttctttatc tacgccgtac tcaacaaagt tatattgaac accgctgaag 3450961 ttgactgggc ttccgtgtgt taaatggccg ccgtgggaga ggttcatccc aagtacagta 3451021 tcgccttgct ccaaaatcgt gaagtacact gccatgtttg cttgtgcgcc tgaatgaggc 3451081 tgaacgttta catgctccgc tccaaagatt tccttcgcgc ggtcacgggc gatatcttca 3451141 acgacatcga cgtgctcgca tccgccgtag tagcgtttgc ccggatatcc ttctgcgtac 3451201 ttatttgtca aaacagatcc ttgtgcttcc ataaccgctt cacttacaaa gttctcagaa 3451261 gcaatcaatt cgatcttagt ctgttggcgt tcacgctcat ttttaatggc gttaaacact 3451321 tgttcgtctt gcgcaggtaa atgtttcatc agcgagatcc tctcctatcc gtatcctgtt 3451381 ctttgttttt accatcacta ttgtacatgg tttttaaggc cgatgtaaaa gattattttt 3451441 aaaaaatcta aatttttatt ggtaaaaacg aatattaata acttaaattt aatttaaagt 3451501 tcggaattta tttcactatc ttaaaataaa agaaaagact ggctatgcag tcctttcatt 3451561 cgcactcata aaccgcccgc actccgccga ttagtttcgg ccgtgtacgc gccaatgtca 3451621 catgagctga accgaggctg ttttgagaga cacgcacagg gacagccacc ggtttcagat 3451681 gcatgccgat aaacgtatcg cctatatcaa ttccggcgtc agcctgaatg gtttcaacaa 3451741 gaacaggaga cttcatctgc ttaaacgcat aagacgccat cgctccgccc gcttttggaa 3451801 cgggcacggc agaaacggtt ggaagcctga acagcttggc tgtttctgct tcgacgacaa 3451861 gcgctctgtt taaatgctcg cagcattgaa acgccagatg gattcccgtt ttttcccgga 3451921 gctcagcaag tccgctgtag atgctttcag cgatatctac actgcccgat gtgccgatcc 3451981 ggctgccggc cacttcgctc gtgctgcatc caaggacgaa gagctgatct tgtttcaatt 3452041 ccgcttggtc ctgaaactca gacagcatcg tcttccacgt ttgtttcaac tcattcatta 3452101 aacagcaccc ctacaggttt ttctcttcat aatcggagat ttttccaata cgcgtttggt 3452161 gtcttccccc ggtaaactca gtagtcagcc agatttttgc gatttcccga gccaaaccag 3452221 gtccgatcac ccgttcaccc atcgcaagga tgtttgtgtc attatgctcc ctcgtcgcct 3452281 tcgcgctgaa ggtatcgtgc gccagcgcgc agcgaatccc ttttacttta ttagcggaaa 3452341 tgctcatgcc gatgcctgtc ccgcaaatta aaatgcctct gtcaacttcg ccgctaacca 3452401 ctttttcggc caccggaaaa gcataatccg gataatcgac agagccgctg ccgcagtcac 3452461 agcccatatc aatatattca atttgcaatt cgtccattaa ctctttgatt tcatttcgaa 3452521 tgtgaacgcc gccatgatcc gatgcaatgg ctactttcat ctgcttttcc tcccagcgtg 3452581 tgtgatgcgg cccgcccgct ttattgaccg cgcagcctgt ccgctctttg attcacacca 3452641 tatgatgtgc ttttcactat attctactcc ttcacgcagg atttgcaaat gacctgtttg 3452701 cagattttct gacaacttat ctacggtctt ttttcagctg ttttgccagc tgccgaagaa 3452761 gctcttcaag ctcatctcgc gtttgtttat agatgtcaat tgagccgccg aacggatcga 3452821 ggacatcacc atggctgcct gtgacatatt cttttaacgt aaacacttta tcacgataac 3452881 gtccaaattg gctggcaatg atctgtttgt gctgatgggt catagccaga accaaatcag 3452941 ccgattccat aagttcttca gttaatggag aagacacatg attaagggca atgtgttttt 3453001 caaacagcgc ttcgactgca tgaggcgtcg ctttcccatt aggtgaagca aacacgcctg 3453061 ccgagcggac attgacattc agcccttccc tttctgcaat tgatttaaaa agcgcctcag 3453121 ccattgggct gcggcacgta tttccagtac agacaaaaat aatatccatg tcagtcaccc 3453181 cttatttttc tctattatat atgaagaaaa aagaaacggc gacttcgttt cttttattgg 3453241 tatattaaat tggcaaaagc agctttaatc caaacacgat taatatgatg cccccgagcg 3453301 cttcgctgta tgtgccaagc catgactgca cttgttttcc gaccagcagg cccagccatg 3453361 tcaacatcat gctgaacagc ccgaacaggg taattgtgag gagcggatgc gagccgtata 3453421 tccccaagct caagccgacg gaaaagctgt caaggctgac gccgatggca aacagcaata 3453481 agcccggccc tgccggtgac atgaatcgtt cttctgactg tttaaaagag gccataagca 3453541 tttgaacccc aagaacaaaa agcagcgccc caccgatata aaccgctaac acgccgagga 3453601 gccctgacag catgttaccg gccgccatcc ctgcgagagg catgatgacg tgaaagaggc 3453661 cgatgatgaa accaatatag aatatctgct tctttctaag tttgaccatg cccattccaa 3453721 ggccgacaga aaaagcatcc atccctaaag caaacgccat gatgcttaat gtaatcagtt 3453781 cgcctataaa caaatccgac atacataaat aacccccttg gacacgcccc gcttttttag 3453841 cctatgcgtg tccaaaaagg gttagaacat ctgactgctt tcagcgaatc actcttcctc 3453901 cggcggcttt catcagcctg ttcataatag caagaccgac acctgtatcc ggaaaggatt 3453961 ccgctataat gaaatccacc ttattctcat caaagctgcg caaagcatca tacagccctg 3454021 ccgcaacagt ctcaagctga gcccgtcttc cgcagctctt cacataatca gcggaataaa 3454081 cgcccgcttt ttcttctgtc gtcaggacac cgacccgtct tccaccctgt tgatattctt 3454141 gaatgaggtg ctgaatgcgc tctgggctgc cttcgcaaat ggcaagaggc gctgtcggcg 3454201 cataatgtgt atatttcatc cctggagaaa tcggcttctc gttttggtcg ctgagccctt 3454261 tatccacatg gatcggcccg atcaccgctt caatttgttc cttcgtaatg ccgccaggac 3454321 gcaagagaac agggatgtcg tccgcacatg aaagcacagt tgattcgacc ccgattccgg 3454381 tagggcctcc atccacaata ccggctatgc ggccatccaa gtcgtgagcc acatgctccg 3454441 cttttgtggg acttggcttg cctgatagat tggcgctcgg tgctgcaatc ggcagtcccg 3454501 attcgcgaat caatgcaagg gcaagcggat gatccggcat tctaatggca accgtttcaa 3454561 gacctgccgt tacacgaggt gaaagcgcat caggtttgca aggcagaatg agcgtaagtg 3454621 ctcccggcca aaaccgtttc atcaatgttt tcgccttttc cggcgccggg cccgttaaat 3454681 cctcaagctg gctgatatcc gcaatgtgga caatcagggg attatcgctc ggccgccctt 3454741 tcgcctcata tatttttttg acggcatccg tattttttgc gtttgcgcct aggccatata 3454801 ctgtttctgt cggaaaggca acgacctcat tttctcggag caaagcggct gcttgtgcaa 3454861 tttgtggatc atttgtggat aactcgtcag ttacatccac aaaccatctt ttcgttttca 3454921 tttctgacca aactccttat tcacaacaat aaaacgattg ttttacgcgt gtaatccttt 3454981 tgaaagtata aaagatgtcc tgtaataaaa caagcgttat ccacaaattg tggacaacgc 3455041 taataaagaa gtggataagt atgtgtataa actgcactta tccagacgct tttttcatca 3455101 aaacggctcc ttctgtttgc cgcgattcac agaagtgatc agaagaaaac agctcctccg 3455161 gtacactctc agctctttca aaacccatgg ccgtcagaaa gtccgcagag gaatgctgat 3455221 ttgctactag gtacacggtt ttgatctgat gcttttcgca cagcacctcc atgctttgaa 3455281 aaagcgtgac gatgtggcct tggtgaagct tgtccgatat gacaagtgat cgcagcagcc 3455341 cctggtcaca gcttattttt tcaataccga ggcatccggc aatgtttttc tcactgtcct 3455401 ccagcataag aaattgagtg aagccttctt tcacgccttc atagctggtt tttgcctgtt 3455461 ttaaaaatgc ctcgagcaca tctccgtctt tttcccttgc cacccgcagt tgataaaaca 3455521 tccgttcacc ccgtttttgc gttctttctt ccaatctatg aggcaaatct atttttagac 3455581 cagatgatta ggaaaaaagg tcggaaatcc attcgactaa aaagaatttc acttctgtgc 3455641 cgtcttcttt ttcttcgttc tcttcttttt tggctttttc cgctttagcg gttacgtcct 3455701 caagcacttt ttcagtctgc ttttttgagg cttctttatc ttcttgttct ttgacggctt 3455761 ccccgttaga aaaatcaaga aagcagaggg gcgggaacag cacacaccac cagttggcgc 3455821 cgtctccgtt tccaagcgta atcaaaatcg cttcatactc accagcggga tataccatgt 3455881 tgccgtaaag ctttgtcgga aacgagattt tgtcaaaatc aacggatatc gactgattcg 3455941 ctccttcttt ctccattgtt tcctttgcaa ttgctttgat ttcaggcagc tttgaacgaa 3456001 tcacgcgacg cgcttcttca atagaagtaa tatcctttac ccaagttgtg atttctttat 3456061 tcaccgcgtc tcttatatga cgttttaatt gctggtcttg atcactatcg ctgtttgcca 3456121 gtattctcaa acgaatcgcc tgatcaggta tgaccaccgg ctgattttcc gatttttgtg 3456181 ccgtctcttc ttttgccagc cctacgagcg ctccggataa taaaagaaag atatatatac 3456241 aaatgattac tgtttttttc atcggtcccc accgttcctc tccgtgcttt gtttctagcc 3456301 ctattatgga caaggagagc ctgggataaa cgtgcagggt gaaaaaaatc tagcaagctg 3456361 ttaatcttat ttatggtacg atagtgtttt aggaggttta agatgaaata caattataca 3456421 gtgctgttat cagcattcac gatgtccgtt ctttattcag taatttatat tcattcattt 3456481 atcattgccg ctctcatcac aatggcattt tattttctgt ttccttattt gatcttcgca 3456541 ctgccgcttc aaatcatgat gaataaaaag ccgaaacgtt tcagcccttt gtatctgctg 3456601 tattaccttg ccgctgcttt tattgccaac gcgatcattt tcggcatgct tcagccttcg 3456661 ggacaatctc tgtttcaaaa tacagccttt tatcttttcg ctgtattaac agctcttatc 3456721 tattggatat gggattctgt tttactgcaa aaaaaggaag cctaagaggc ttcctttttt 3456781 attaaaacaa aatcgtcagt aaataacata gaatggaagg tatcgccgca acaaagaaag 3456841 cggccgccat tttcatgcga gatgtacggc cttctttggt ttctgaatgg tagtttgccc 3456901 gctgatcgct tccgcttaca gccaaacccg atgtaatgat cgcgagcccc actaaaacga 3456961 gagacgcaac gccaaaaatc gcttcatatg aaagagcctg cggaaaaatg gtgccaatca 3457021 tgctctcaat cgcaatgagc aggattcctg ctgtcagggc ctttttcatg tttacatccc 3457081 ctttgctggt gttaaacagc ttgatccatt cactcgccag caagctgctt atttattttt 3457141 atgaatcaga gcgcatatgg ttctgtcttt tccattaata tctttcagca cttccacttc 3457201 cgccccctta aacgccttga ggatcaggtc tttgaccgcc gctccctgtt tccagccgat 3457261 ttcaaaaacg acaaatactt tatccttcat aacaagcgga atgtcttcca taaaccgctt 3457321 ataaaatttc agcccgtctc cgccatcggt gagtgcgtgc agcggctcat gaaaacggac 3457381 aatttccgat aaatcagcca tttcttcctc tgaaatatat ggcgggtttg agacaatgat 3457441 atccgctttt tttcccgcct taataaaagg ctcaagcaga tcgccctgat aaaagcgcac 3457501 attcgctccg agtttttctg cattggcaga ggcgacttgc agcgcctctt tcgaaatatc 3457561 gaccgccgac acagaaaagc tttggttttc aagcgcaagc gtgacggcta ttgcgccgct 3457621 ccctgtacca acgtcaacaa cttcgagctt gccgtcttca gaaaaaacac tccgatattt 3457681 ttcaagcaaa tgaaagacaa cttcttcagt ttccggccgc gggatcagca catcatcatt 3457741 caccataaat tcccgtccat aaaaaaactc ttttcctata atgtattgaa ccggcacgcc 3457801 ctctttatgc atctcaacgt gacgcttaaa gcgatacagt tcgtcttcac caatcggttc 3457861 ctgtaagctt gcgagcagct tgcttctctc cattccggta tcataaagca ataggagctc 3457921 ggccgcattt tcttctcttc ccgcttcggt taaataagaa gaagcccatt tcagggcttc 3457981 gaatatcgtc ttcatcttaa ccttccgact gctgaagctt gcttgcctga tcttcaacaa 3458041 tcagcgcttc aaccacttcg tcaagttttc cttcaagaat ctgatcaagc ttttgaatcg 3458101 tcaaaccgat tctgtgatcc gtcacacggt tttgcgggaa gttgtatgtg cggatacgtt 3458161 cagagcggtc accagatccg actgctgatt tccgtgtttg atcatattca gcctgggctt 3458221 cctgctgaaa tttatcatag attctggcac ggagaacctt cattgctttt tctttgttct 3458281 taatttgaga tttttcatcc tggcatgata caacaacacc tgtcggcaag tgagtcagac 3458341 gaaccgcaga cattgttgtg ttaacgcttt gtccgcccgg tccgcttgaa gcaaatgtat 3458401 cgacacggat atccttctca tggatgtcga cctctacctc ttctgcctca ggaagacatg 3458461 ccactgttgc agtggatgta tggatgcgtc cgcctgattc tgtttccgga acacgctgta 3458521 cgcggtgggc gccgttttca tatttgagtt tagaatacgc gccgcttcct gtaatcataa 3458581 agatgatctc tttgtagccg cccgttccgg ttacattcgc ttccatgacc tctgttttcc 3458641 agccctgaag ctcagcataa cgggaataca ttctgtacag attgcccgcg aataaagcgg 3458701 cttcctcgcc tcccgcagcc ccgcggatct ccatgataac gtttttgtcg tcattaggat 3458761 ctttcgggat caggagcacc ttcagccgtt ctgacagtgt ttccgtttcc ttctgaagtt 3458821 cagaaatctc ttccttcacc atgtcgcgca tctcagcatc cagcttctct tcaagcatcg 3458881 cttttgcatc agccagctgt tctgacgcat ctctgtattg tctatatacg tcaactgttt 3458941 cttgtatatc agattgctct tttgaatatt ctcttagctt tttcggatcg ttgactactt 3459001 ctggatcgct caaaagctca tttaatttct cgtatcgttc ttcaattgat tttaaacggt 3459061 ctaacacggt cttcacctct gttttcctgt gcgtaacatt ctcattatag tatagtgatt 3459121 aaccccagtc aaaagcattt caatcccagc tggaaaagct ccctctgcta tactggaatt 3459181 cgaggaggga tgatgttgct gaaatccata catcatattg caatcatatg ttcagattac 3459241 gaaaagtcga aagctttcta cgtacataag cttggttttc aggtgattca agaaacgtac 3459301 cgcgaagagc gcggctccta taagcttgat ttgtcgctta acggctcgta tgtcattgag 3459361 ctgttctcgt ttcccgatcc gcccgaacga caaacccggc ctgaagccgc aggcctgcgc 3459421 cacctcgcct ttacagtcgg cagcttggat aaagctgttc aagagcttca tgaaaaagga 3459481 atcgaaacag agccaatcag aacagatccg ctgaccggca agcgtttcac cttctttttt 3459541 gatcctgacc agcttccatt agaactgtat gaacaataac agtttttgaa gaaaaaaagg 3459601 agatacccac tttctttgcc gaatcttttc ttgttttgtc taacgggaag ggaaccgcat 3459661 tctatggtcg aatacctagc ttaaaaggag gtatgggatc atgaatacaa atatggtagc 3459721 aagtgaactc ggcgtctccg caaagacggt gcagcggtgg gtgaagcagc tgaatcttcc 3459781 ggccgaacgc aatgagctcg gacactattc gttcacggca gaagacgtga aggttctaaa 3459841 atccgttcaa aaacaaatct ctgaaggcac ggcgattcag gatattcatc tgccgaaaag 3459901 cgctaaaaag cgcacaggct tccttgtcca aaaaacaagt agcgacacag aacgaagaat 3459961 cgagcagctt gaacaaaagc tggacaccct tttacagcaa aggcaggacg aaagcgaatt 3460021 gatggcaagg atgtcggaac tggaacgcca gctgaaacaa aaagccgatg aaggtgtatc 3460081 ttaccagctg cttcagcacc gcagagaaat cgatgatatt cttgcagatc tgcaatcact 3460141 gacctcacaa atgaaagaat tcaccgctca ttcgatcccc gagactgctg ctgcttctga 3460201 aaaaaccaaa acaagaaaaa aaccgctgct gtcactgttc aaatttcaaa cctaaagcaa 3460261 aaagctccct taaagggagc tttttttgtt acgcagtaag cgcgataatg attggaagtg 3460321 aaatcaatga cagaatcgca ctgaccacaa acgcagttgc agtttcttct tcttgtttct 3460381 cgaaacgagt cgcaatcatg gctgcaacgg cagaaccagg gaatgcaaca agaaggattg 3460441 cttttgttgt ttggtcagct ggaagtccga tagcaagagc aatcaggaac attaacgcag 3460501 gctgaaccgc aacttttagt aacgcaatac cgatagccgg catactgagt ttaattttac 3460561 gaataccaac ggtaacacca acagcgaaga gagcaacacc agatgttgtg cttccaagct 3460621 gatcaagcat tttaacaccc agctcaggaa gagtgaaatt gaaaaccagc accaagatca 3460681 tactgattaa cggagcagct gcaagcggct cacaaagacc atgcaggatt gattttcctg 3460741 tcatcttcca gaagctgtcg ccactctctt cgtttttctt agaagactca ccaacagtag 3460801 cgataatgat cgcgagcgga tcaagaatcg cgttaaccac gatacctgtg accgcgatcg 3460861 gaatcgcaac ttcattcgct ccgaataagc ttcccaatac cgggataccc ataaatgcga 3460921 atgtcggctg tgcagagttc aaagaaaata cagatgagtt cgttaaatca tacttgaata 3460981 taaatctgca aaccaaaaga atgatgatat agaaaccaac aatcccaata attaaagaaa 3461041 tcattaaagg tacttgtgat aaaaattcac ttctggaagt tgtcaaaata ccagcgataa 3461101 agtgagctgg aagtgcgtat ttcgttacta acgtacttac cccttttgcc gacttggcat 3461161 cataacttcc aaaatgtcct gcaaaccaac ccagcacgat aacaaagaag atcggcgcca 3461221 ggaggattaa gatatctaag atgctcaaaa tattctcctc caaatcctat gtccgtatac 3461281 tttagcttta caaaaagctt tccctcggac agaaaaattt actcgctaat tatttcgcga 3461341 tgactttttt gtattcaggt gtccacattg catcaagtac cgcttgtttc acatcttcag 3461401 gctgacgatt tgccacgccg tctttaattg ctgcttcagc aacggcaatc gcaacttgga 3461461 tagaaacctc ttgaagctta tcaatgcttg gaagcaatcc tgctccaggt gtttcaagat 3461521 caaccatttc agcaatcgca tcagcagttg cagcaaacat agcaggtgta atgatacgcg 3461581 cttcagctac aattgaacca agtccaagac cagggaacgc gaatgcgttg ttagattgtc 3461641 cgatttcata agaaacaccg ttgtattcta cattgtcaaa tgggcttcct gttgcaataa 3461701 gcacttttcc gtcagtccat ttgaacagat cttcaggaac agcttcagca aggtgagtcg 3461761 ggttagacat cggcatgata accggacggt ctacgtgaga tgccatttct tttacaattt 3461821 cctctgtgaa tgcacctgaa acccctgaag taccaatcaa gattgttggt ttcgcttgac 3461881 gaacaacttc atcgaatgga atttgacctt tttcatcgcg cttccagtct ttcacttcat 3461941 ccgcattgcg aaggtaaggt ttttggaaat caaggatgcc ttcgatgtct tcagtcagca 3462001 agcctctgta atcaagtgtg tagaaacgtt tgttagcttc ttcttcagat aatccggcta 3462061 gcaccattgt gtcacggatt tggtcagcaa taccgatacc agcagaacca gcaccgaaga 3462121 taacaacacg ctgatcttta atagaagcgc cggttttctt catagcggca agcacacctg 3462181 caagtgtaat cgcgccagta ccttgaatat catcattaaa tgtcaggatt tcatgattgt 3462241 attttttcat gatgttgcgt gcatttttgt tgccaaggtc ttcccagtga agaagcgctt 3462301 tagggaagaa tttcaatgca gcttttacat aagcgtcaat gaaagcttcg tagcgttcac 3462361 cttgaacacg ttcatgcttg ttaccaatat ataaaggatc gtttagaagt ttttcgttgt 3462421 tcgtaccgac atcaagcaca accgggataa cacggctagg gtcaatacca gctgcagcag 3462481 tgtagacagc caatttaccg attgcaatat taataccgcc tacaccccag tcaccgatac 3462541 cgagaatgct ttcggagtca gtagcaacga taagatcaat atcgcctgct gtcgcatgaa 3462601 ggttttcaaa cgctttttca ataccgtcaa tgttatcgat tgacaagtag attccttgag 3462661 gtcttctata ttcatggctg tattcctgaa tcgcttcacc aactgttggc gtgtacacaa 3462721 caggaagcat ttcgcgaaga tggtttttca gcaatttata gaaaagaact tcgttacggt 3462781 ttgcaagatc acttaagtaa acattttgac gaaggcggtc aggctgcgct tggaattgct 3462841 cgtacgcgcg ttgtgcttgt tgatcaagag aaagtacagt tggcggcaga agcccttcta 3462901 agccgagttc ttgtctttct tctagtgaaa aagcaacgcc tttatttaaa gtaggaatag 3462961 ataaaacttc ttttcctcta agagttgttt ctaagtggcc ttctttcgtt ttttttatgt 3463021 tattcaagca aatctccttc tttcttgaaa tagttaacca agttaagtaa taacccatct 3463081 aaaatatgac cgatcatgat ctttatgcga ctttgtgaca attattcgaa caatgtctca 3463141 aaactattta cattacgtaa gctattgtat gcctgtcaaa atcaaaattc aagagaagaa 3463201 aattacttaa ttttttaata tacttattta aattttttaa ttgaatatta tcagaatata 3463261 aaaaaaacac cggtgttttt agccggtgca ttctatcttt atacccatgt tttggactat 3463321 tttttagatt tacctgggac ttcgtgatga tgtctgcatc ttgcttcata tgattcagct 3463381 gcaccaacca aaatgaccgg atcatcgtaa gaagcaggtt tgccgtcaat gaggcgctgt 3463441 gttctgctcg ccggtgatcc gcaaacagaa cagacggctt gcagctttgt cacactttcc 3463501 gcaatcgcca tgatattcgg gacgacaccg aacggctctc ccctaaaatc catatcaagg 3463561 cctgctgcta tcacacggta gcctttatcg gcaagagatg ataaaacctc aacaatttcc 3463621 tgatcaaaaa actgcacttc atcaaccgca accacatctg tactttcact gatgtgatcc 3463681 caaatgtccg cagcagacga aatggcatag ctcgtcatcg atgttccatt atgggagaca 3463741 acagcagctt cgctgtatcg gttatcaatt acaggcttaa ataccctgac ttcctgcttg 3463801 gcataagttg ctctcttcac tcttctgatc agctcttcag atttccccga gaacatgctg 3463861 ccgcaaatca gctcaagcca cccgctttgt ttcattatgt acataggctt cgctcccctc 3463921 tctctgccag ctgtgtttta gacaatataa aaaacaggca agactgctgc ttgcctgttg 3463981 agaaatctat tattacttaa gaccgtattt tttgttaaag cgatcaacac gaccatcagc 3464041 agaagcgaat ttttgacggc cagtgtagaa tgggtggcat tcagagcaaa tctcaacgcg 3464101 tacctcttct tttactgagc ctgtttcaaa ttcatttccg caagcgcatt taactgttgc 3464161 ttttttgaaa ttaggatgaa ttcctgcttt cattgtatcc atctccttcc gccctgaatc 3464221 ccgtgtggaa acagagttat tatttcggag cattgtccga aacgcatatg agaaaattat 3464281 atcagtgatt tacttctttt gcaaatacaa tttaccttct tgcagatgat agatttgcct 3464341 gtttccattc ttgattgaga atatcgaaaa attcctggtt tgttttggtt tttttcattt 3464401 ttctcatgaa cttttctgcg aaatcaggtg aatcagacat cgttttgcgg atagaccata 3464461 aacgatcaag atgctcttta ggcacaagca gctcttcttt gcgcgttcct gaacggcgga 3464521 tatcgatggc agggaagatg cggcgctcgg caagagagcg gtcaagatgg agctccatgt 3464581 tgcctgttcc cttgaattct tcataaatga catcatccat acgtgaacct gtatcgacca 3464641 gagccgtagc aaggatggtt aagctgccgc cctcttcgat atttctcgca gccccaaaga 3464701 agcgtttcgg acggtggaac gccgctgggt caatcccccc ggaaagcgtt cttccacttg 3464761 gcggaatcac taagttgtag gcgcgggcaa gacgtgtgat gctgtccatc aggataatga 3464821 cgtctttttt gtgttccacg agacgcatcg cacgttcaag cacaagctcg gccactttga 3464881 tatggttttc cggcacttca tcaaacgttg agctgacgac atccccagct acagagcgct 3464941 cgatatcggt tacttcctca ggtctttcgt caattaaaag cacgatcagc tctgcttcag 3465001 gctggttcgc tgtaatgctg ttggcaattt ccttcagcaa catcgttttt ccggctttcg 3465061 gcggcgcaac aatcaatccg cgctgcccaa atccaaccgg cgccatcatg tccataattc 3465121 ttgtagacaa gaagttcggc tttgtttcaa gcaccatttg acgatccgga taaagtggcg 3465181 taagagccgg gaaatgcaca cgctcttttg cagattcggg atcatcccca tttactgctt 3465241 caacgtgcaa aagtccatag taacgctcat tttcttttgg cgggcgaacc ttgccagata 3465301 ctttgtctcc gttccgcaaa tcgaaacggc ggatttgtga agctgagatg taaatgtctt 3465361 ctgagcttgg agagtagttg atcggtctca ggaatccgaa accttcagac tggatgatct 3465421 cgagaacgcc ttccataaac agcagatctt cctgttctgc attcgctttc agaatggcga 3465481 aaatgagttc tttttttgtc agtttgctgt aataggagat tttataatgt cttgcaagtt 3465541 cataaagctc tttcaatttc atattttcca aagaggaaat agatacgtct ttcataaaaa 3465601 caccacgctt ttcatagtca atatcttact ctgaacatgt catctgctgc ttttgcacaa 3465661 catccgccaa agcacattct ttttttaaca taaaggaact tctatcggta acacttccac 3465721 ccatgatcgg cgcttttgtt aaaaggattg tcttaatgag ttttgaagga agcgaggaca 3465781 aaaacatgag aagatcaata cttatatcgt ctgtatgcgg tagaaattga aactttccta 3465841 gtgcttaaaa gaaggtatta cgcagtaaaa ttcgcagcac tctttatttt taccttattt 3465901 caaaaaatta ttcaactgaa ataaggtttt gacacggaat tgatagagtt gacgcttttc 3465961 tgcaaaagtt aaagcgggct cacacccgct ttttctgttt gttatggacg gattacaaga 3466021 tttggtttct ttttcaagct gtgtctgccg tcaacgaaac gaacagtgcc cgattttgca 3466081 cggataacta agctttcagt tgtaccgaca gagcctttga attgaactcc ttttaacagc 3466141 tcgccgtcag taacccctgt agctgcaaaa atcgcgtcat cacccttcac aaggtcttcc 3466201 atgcgaagca ctttgcttaa atcaaggccc attttgtgac agcgagtgat ttcttcttcg 3466261 ctttgcggaa gaagtttacc aatgatttct ccgccgagtg cttttagcgc aacagcggaa 3466321 agcacaccct caggagcgcc gcctgatccg aacaggatat caacgcccgt gtggtcgaaa 3466381 gccgtgttga tggcgcctgc gacatcgccg tcattgatca atttgattct ggcgccggcc 3466441 tcacgaagct cggaaatgat ttttgcgtgt ctttcacggt ttaaaattgt ggcaacgacg 3466501 tcctcaacgt ccttgttttt cgcttttgcc accgctttaa ggttgtcaat gacaggtgct 3466561 tcgatgtcaa tgcagcccac cgcttccgga ccgactgcga ttttttgcat atacatgtca 3466621 ggagcattca gaagcgtgcc atggtctgcg accgcgataa ccgtcagcgc gttccagccg 3466681 ccgcttgcta agatgtttgt gccttcaaga gggtcaactg cgacatcaac gcgagggccg 3466741 tacccgtttc cgagtttttc cccgatatac agcattggcg cttcgtccat ttccccttca 3466801 ccgattacaa cggtcccttt catcggcact gtatcaaaaa cgtctctcat tgcacttgtt 3466861 gccgcttcat cagcctcatc tttttttccc cggcccatcc atcttgctga tgccaatgcc 3466921 gcagcttctg tcacacgtac caattccatt gataaacttc tttccatttc aacacgatct 3466981 cctctcacaa gaaaccatta tgaattttga agctgttcta tttcttcgtc agtcattctt 3467041 tcacgccaaa ttgtcgctcc aagcccctca agcttcttct caaggctgct gtatcctcgg 3467101 tcaatatgct ccagtcccgt aatttccgtg acgccatcag ccatcagtcc ggctaccacc 3467161 aagcaggctc cggcacgcag atcactcgcc ttcacttttg cgccttgaag ctcgacagga 3467221 cctgtgatga tggcagatct gccttctact ttcatattgg cacccattcg tctcagctca 3467281 tcaatgtgct tgaatcttgc cgagtagatg gtgtctgtga cgacactcgt ccctttcgcc 3467341 cttgtcagga gcgccgtcat cggctgctgt aaatcagtcg gaaaccccgg gtatacgagg 3467401 gttttgacgt caaccggctt taagttcttc tgcccgccga caatgaggag ctggtcgtcg 3467461 cttgtttcga tatgatagcc catttctctc agctttgccg ttaacgactc aagatgagta 3467521 gggatgacgt tatcgataat gacttccttg cccattgcag cccctgcaat cataaatgtc 3467581 ccggcttcaa ttctgtccgg aatgatcgta tgcttgcagc cgtgcagttc cttcacgccg 3467641 tcgattcgaa tcacattggt gcccgcacct ttgattttgg cgcccatgct ggtaagcaat 3467701 gtcgcgacgt caatgatctc aggctccttg gcagcgtttt cgatgatcgt tttcccttct 3467761 gccaaaacag cggcgagcat aatgttaatc gttgccccaa cgcttacgac atctaaataa 3467821 atccgtgcgc ctctcagcct ttcagctcgc aaataaatgg cgccttgttc attggttact 3467881 tcagctccga gtgcttcaaa gcctttgata tgctgatcaa tcggacgggg ccctaagtga 3467941 cagccgccag gcaatccaat gaccgcctgc ttgaagcggc cgagcatcgc ccccattaaa 3468001 taatatgacg cgcgaagctt ttttactttc ccgttaggaa gcggcatgct gatcatcgac 3468061 gtagggtcaa caaccatttc cccattctca aaatgcacgt tgccgccgat ttcctttaac 3468121 aggtcacgca gcgtttcaat atctgaaatc tctggaagcc cttcaattgt cacctcggaa 3468181 tttgccaaaa tggttgcagg tattaacgca acagcgctgt ttttagcgcc gctgatatgt 3468241 actgtaccgt ttaacgagtc accgccggca atattcaact tttccatgat agtctccttc 3468301 cataagaaga tagctgcgga gctaaataaa atgtcatttt attctgtctc tgcaaataaa 3468361 gctcatgtcc aaaatctagc caattcgaag agaaagaata caacacattg taaaatatca 3468421 ggaagaaaat agcgaagctt tggggggtac aggtttcaaa agatgcacag agacccgccg 3468481 gctcgagaga catcgtcgtc atccggcaaa agcagtacgc atacccttca ttccgatatc 3468541 agcttctgca gcccaatgat tccttctctg taaagcggcg tcagcatctg aagatccgct 3468601 gtatcaggtc ggtgaaatac aaaggccgcg gcaaacaggc ataaagctgt ttgccgcccc 3468661 tttcattatt tgttccagtc tgccaggaat tgttcgattc ctttgtctgt taacgggtgt 3468721 ttagtgagcg catgaatgac tttcagcggc attgtgccga tatgagcccc tctaagagca 3468781 gcttctgtca cgtgctgcgg atggcggatt gacgctgcaa tgatttgcgt gtcaaggccg 3468841 tgaatgtcaa aaatctgttt aacttctgaa atcaggtcaa gcccgttgtg gccgatgtca 3468901 tctaaacgtc ccaggaatgg agatacatat gttgcccccg ctctggcagc aagaagcgcc 3468961 tggttggcat tgaagatcaa tgtaacgttt gttttgatgc ctaagtcagt aagtgctctt 3469021 accgctttta aaccgtcaga cgtcattggg attttcaccg taatgttcgg agcgatcttc 3469081 gccagttctt ttccttcctc gatcatttcc tcagctttca aagaaataac ctctgcgctt 3469141 acagaccctt tcacgacgtc tgtgatctcg cgaagacggt cgtggaatga tacgttagct 3469201 tcctttgcta ctaaactagg attcgtcgtt acaccggcga gaattcctaa ttcattcgct 3469261 tctctaattt catcgatatt ggctgtatca acaaagaata acattttcaa aaagcctccc 3469321 tgattaagaa attttctgaa ctgcgaatat gattgcgctt tctaaagata gacggaaaac 3469381 cgcctgtcaa gctgtcaggc ggctataaaa agttccaatt gaattaagct tggtttgaag 3469441 aaccaaattc acgcatttta ccgataactg tttctttgat cgcttcacga gctggtccaa 3469501 ggtatttacg tggatcgtac tcgtcaggct tagctgccaa tgtttcgcga acagcttttg 3469561 cagaagaaat ttggttttca gtattcacgt tgattttagc tgtaccaagt gaaattgatt 3469621 ttttgatgtc agcagtcgga attccagtac cgccgtgaag aactagcgga aggccagttg 3469681 attttccgat ctcttccatt tctttgaagc caaggtttgg ctcacctttg taagggccgt 3469741 gaacagaacc taatgcaggt gcaaggcagt cgatgccagt gcgctcaaca agctcttggc 3469801 actctttagg atcagcgtag attacgcctt cagcgataac gtcatcttct tgtccgccta 3469861 ctgttccaag ctcagcttct acagatactc cgtggaaatg agcaagctca acaactttag 3469921 cagttgttgc tacgttttct tcaaatggat ggtgagaagc gtcgatcatt acagatgtga 3469981 aacctgcatg aatcgctttc gcacaagatt caaagcttga accgtggtct aagtgaatcg 3470041 caacaggaac tgtcactttg tactcttcca taagtgcttt taccatagca acgactgttt 3470101 tgaagccgcc catgtagcgt cccgcacctt cggaaacacc aaggatcact ggagattttt 3470161 cttcttcagc tgcttgtaaa atcgcttgag taaactcaag gttgtttaag ttaaattgtc 3470221 ctacagcgta ccctttttct ttagctgtat tcaacatttc cgtcatagaa actaaaggca 3470281 tgtcgaatgt cctccttatg tagcctgatt gtcttctagc gaaaaaagct ttccacccta 3470341 gcatgaccca tatattgctg tcatatgtaa atactcagat cgctttttct ccataactag 3470401 gataccaact tttcgacaaa tcggcaacat aatgacatga ttcatttgtt tcttcttttt 3470461 gtcagttaga cttcaggggc agatattttt tgacggcgtc tctgatttcg tcgatgtcaa 3470521 acggcttggc aaagtgcgtc agagcgccca attccttcga ttcctggatc atgtcgagct 3470581 ctccgtatgc cgtcatgata atgacccgga tgttttcgtc aatgaccttc atccgtttta 3470641 agatttcgat tccgtccatg ccgggaattt tcatgtccaa cagcacaagg tcgggccgtt 3470701 cttttgtcac aatgtcaagc gcctgcaggc cgttcgcagc ctgaaacgtc tggtagcctt 3470761 ctttattgaa cacttcattt agcaaaatac gaatgccgta ttgatcatca acgattaaaa 3470821 ttttttcatt catcatttta caccccaata ttatgatttt cgtcaaaagt aagcagtatt 3470881 gtatgtattc tgtttgattt tcctatttcc tttaattata atagtctact ttacgacatt 3470941 ttctgagcat tttctctttt gttgtatact gatattgtac gttataaagg aggattcact 3471001 tatgttgaaa atattcacga cgcagttaac aggtattttt tcccgcattc aggataagga 3471061 atctgacgcg attgaagatg gggcgcggct gcttgctcaa gcggtgatca gcgggcattc 3471121 catttattta tacggagcga atgagcttca gggcgtcttt tatgaggcca ccgaaagcaa 3471181 agaacccttc ccatctgtca aagcctttcc agaaaacgct gaggaagtga cagaaagcga 3471241 cagggtgctg atgttttgct cagggacggg cacagccgaa gaacaggagc tcgcaaaaga 3471301 gctttatgaa aaaggtgcgg gagtcgtatg cgtatcgccc gcagccaaag acagtgcggg 3471361 aatagaacag tattgtgatg tgcatattga ttctaaatta aaaatgccgc ttgttcccga 3471421 tgaagacggc acccgttacg ggtttccctc tttaatgaca gcactgtatg tctatcacgc 3471481 tttatcgttt acactaaaag aaattctgca agagtatgca taatatctta ttgtacatgc 3471541 tggaacttgc cggaaacaaa taaaaaagac ttgcccgctt ttgacaaacg gcaagtcttt 3471601 tttattactt ctgatttgca gcttcgacag acgctccgat aaagcctttg aatagaggct 3471661 gaggtcttgt cggtcttgac ttgaactctg ggtggaactg agaagccacg aaccaagggt 3471721 ggtctttcag ctcgatgatt tcaacaaggc gtccatcagg gcttgtgcct gagaatacga 3471781 agccttgctc ttccatttgc tgtctgaatt cattgttaaa ctcatagcgg tggcggtggc 3471841 gctcgtacac cacttcatcc tgatacactt caaaggcttt cgtgccttct tcaagcttac 3471901 aagggtaaag gccgagacga agcgttcccc caagatcctc aacatccttt tgttcaggaa 3471961 gaagatcaat gatcgggtat tgagttgacg gatcaatttc cgctgagtga gcgcctttta 3472021 agcccaatac gtttcgtgcg tattcaatag acgccacctg catgcccaag caaatgccca 3472081 agaacggaat gttgttttcg cgcgcgtatt ttgtcgcgac gattttccct tcaacaccgc 3472141 ggtctccgaa tccgcccggc acaatgatgc cgtctgttcc gcttgtgagt tctgcgatat 3472201 tgttttctgt cacttcttcc gcgttgatcc acttcacttt tacatctgtg tcaaacgcat 3472261 agcccgcatg gcggagagac tcgacaacag aaatgtatgc gtcaggaagc tcaacgtatt 3472321 tgccgacaag gccgattgta atcgtttgag acaggttgct gactttgtta acaagctctt 3472381 tccactcgga catttccgct tctttgcatg ccaatttcat gtgctcgcaa acaagcttat 3472441 caagcccttg tttttgaagc tccagcggaa tggagtaaag gttgtccgca tcttcacatt 3472501 caataaccgc ttttgtatcg atgtcgcaga aaagcgcgat tttatctttc atatcttgag 3472561 aaatcggcat ttctgtacga acgacgatga tgtttggctg aatgcccaag ctgcgcaatt 3472621 cttttacgct gtgctgtgtc ggttttgttt ttaattcgcc agcagcttta atgtaaggca 3472681 cgagcgtaca gtggatgtac attacgtttt cacggccgat gtcgctcttc atttggcgga 3472741 tcgcttcaag gaatggcagt gattcgatgt ctccgacagt accgccgatt tctgtaatga 3472801 caacatctgc gtttgtctct ttccctgcgc ggtaaacacg gtctttcaat tcgtttgtga 3472861 tgtgcggaat gacctgtacg gttcctccaa ggtaatctcc gcggcgttct tttttaagaa 3472921 ctgttgaata gattttacct gttgtcacgt tgctgaattt attcaggtta atgtcgataa 3472981 aacgctcata gtgaccaagg tccaagtctg tttcagcgcc gtcatccgtt acgaatactt 3473041 caccgtgctg gtacgggctc attgttcccg ggtcaacgtt gatgtatgga tcgaattttt 3473101 gaatcgtcac gttcagtccg cggtttttca gcaaacgccc taatgaagct gctacaatac 3473161 cctttccaag tgaggataca actcccccgg ttacaaaaat atatttcgtc atttcgtttg 3473221 ctcctctctt cgctcttagc tacattttta aaatgtacta ttttataaaa aatcatttag 3473281 ccttttaaat gatttataag aaaaatgagg ggtgaaaata agaaagctcc ctttcaattt 3473341 cttgaaaggg agcataacgt actatgttct ctcttcgttt ttgaagagcc caaaatacat 3473401 actacatagt tcgactatga aagtcaagat cgttttgaag atgaaatctg atactattta 3473461 atttcctctt cttcatcatc atagtcttca tcatcttcat caataatatc ttcttcgatc 3473521 tcaagatcat cgtcgtcttc atcaagatct tcttcgtcaa aatcgtcggc ttcaagatcg 3473581 agttcttcct caacttcatc caaatcaagg tcgtcttcgt cgatctcttc aaactcgtca 3473641 agatcaagat cttcttcgac tgctttcttc gcttttttct ttttcgcctt gactgtcggc 3473701 tgagtttctt catcaagctg atcataagga taccagctgc gaagccccca cgtctggtca 3473761 gaaagcgcca ggaagcggcc gtcaatgttt aaatctgtat aaaattgagc aatgcggtct 3473821 ccaagctctt cttttttcac gccgagcaaa gatgcgattt catttaaaag ctcctgaaaa 3473881 ggaactggtt ttttatgttc ttcaaataat tcgtgagcga tttcaactaa agccatttcc 3473941 tttagctctt cctgtgaata ttgtttgata cccaaggtcg gacactccct ttctattact 3474001 tatatgtatc tgttttatca ataatgaaag cgattttgta tcgttcttat acaaaccata 3474061 cctctcatta taaacaaaat aaaacagaat atgctaccct taacagcgtt aatttaaata 3474121 attttacaag agtgatccga ctgagagatg ttttccgtta atccgcgagc attctggaga 3474181 tgaccagtct ttgaatttct tgagtgcctt catagatttg cgtgattttt gcatcacgca 3474241 tatagcgttc taccggataa tcttttgtat agccgtagcc gccgaaaatc tgcacggctt 3474301 cggtcgttac cttcatcgcc gtatccccag ccatcagttt ggacatggcg gaagcttttc 3474361 catatggaag gcccgatgat tctaaccatg cagcctgata ggtcagtagc cttgaagctt 3474421 ctatcattgt cgccatatcc gcgagtttaa aagcgatgcc ctgctgctcg gcgatcgatt 3474481 ttccgaattg ctttcgctct tttgcatatt gaagcgccgc atcaagcgct ccttgggcga 3474541 tgcctacagc ttgtgcagct atgccgtttc tgcctccgtc aagcgtcttc atcgcgattt 3474601 tgaagccttc tccttcttct ccgagacgct ttgatgcggg cactacacaa tcttcgaaca 3474661 tgatttccgt tgtcggtgaa gaacggatgc ccagcttctt ttctttcttg cctgtaaaaa 3474721 atccttcaaa atccttttct actataaaag cggtaacgcc ttttttcttt ttctcgggat 3474781 cggtgacggc aaaaacaatg taaatatcag caacgccgcc gtttgtgata aacactttgg 3474841 aaccatttaa cacatagtca tcgccgattc gttcagcagt tgttttcatg ctgccggcgt 3474901 cagagccaga ccctgcttcg gtcaaagcga atgcgccgat tttctctccg agagccagct 3474961 gtgttaagta ctctgtcttc tgttcctctg tcccaaaggc aaacagcggc cagctgcaaa 3475021 gagagatatg ggcggaaagc gtcacaccgg tggaggcgca cacttttgac agctcttcca 3475081 ccgcgatgac gtaggctaaa tagtcacttc caattccgcc gtaatcttca ggccatggaa 3475141 ttcccgtcag gcccagattt gccatttccc gaaacagctc gcgatcgaag cgttcttgtt 3475201 cgtcccgttc agccgctgtc ggggccacct catgcttcgc aaaatcgcgc accaattttc 3475261 gtatcatctc atgttcttct gataatgaaa aattcattgc ttctccccca ttttcagatc 3475321 agcgcctaaa acggattgag ccagaagctc gacgacgtcg tacgttttga cttggtcttc 3475381 ggcttccttc gcctttgtgc cgtccccaag catcgtgaga caatacggac agccagaact 3475441 gatcaccgat gggttgactg cgagcgcttg ctctgtcctg gcgacgttaa tcctgttgcc 3475501 tgtttcttcc tccatccaca ttaatccccc gccggctccg cagcacatgc cggtttcccg 3475561 gcttctctcc atttcaacaa gctgcacgcc cggaatggct ttcaaaatct ctctcggcgg 3475621 atcatagact tcattgtacc ggcccaaata gcacgaatca tggaaggtaa tcgtctcatg 3475681 aagcgggtgc tgcggtctta attttccgtt tttcacaagc tcggccagca cttctgtatg 3475741 atgataaacc tcgccttcaa atccgaaatc cggatattcg tttttaaata aattgtatgc 3475801 atggggatcg atcgtaacga tttttttgac atcatttttt tcaaattcag aaatattctt 3475861 ctcagccagc tcttggaaca aaaattcatt tccgaggcgg cgcggcgtgt ctcctgaatt 3475921 tttttcttta ttgccgagaa tcgcgaagga cacgcccgcg tgattgagca gcttggcaaa 3475981 ggaaattgcg attttctggc ttctgttgtc gtaagacccc atggagccta cccagaaaag 3476041 gtactcaaat tcttttcctt cttttttcat ttcttttaca gtcggaatct cagcatccgg 3476101 cgcctcgtca cgccaatttt cacgttcctt gcggttgagt ccccacggat tcccttgccg 3476161 ctcaatactt gtcattgcgc gctgggcgtc actgtccatt tttccttctg tcagtacgag 3476221 gtagcggcgg aggtcgatga ttttatccac gtgctcattc atgaccgggc attgatcctc 3476281 acagttccgg caagtggtgc atgcccaaat ttcttcctct gtgatgacgt cgccgatcaa 3476341 gcttggattg taatcaagcg ccgctgcggc ttcctgcgat ccgctgcccg ctgacgccgc 3476401 agccagctga ttgcctctcg tatgccgaaa cgctgctgcg ggcacccatg gggagcgcga 3476461 ggtgacggca gcgccttttt ccgtgagatg gtctctgaga cgcaaaatca agtccatcgg 3476521 agaaagcatt tttccggtgc ctgttgcagg acacatattg gtacagcggc cgcactcgac 3476581 acacgcgtat agatcaagca gctgagactg tctgaaatcc tcaatttttc ccgctccgta 3476641 gctttctttc gtttcgtcgg taaaatcaat tttttcaagt tttccggcag attccattcg 3476701 attgaaaaag acgtttgccg ggccggcgat taaatgggca tgctttgact gaggcacgta 3476761 cactaaaaag ctaagcaaga ataggagatg gatccaccat gcgatataga aaatcaccgc 3476821 cgcgcctgtt ttcccgacac cgctaagcat aaacgcaata cctgaggcaa ttggctcgct 3476881 ccaagaaagc ccatgctcat gccaaatcag attcatcccg ttcccaagca gaacggtcag 3476941 cattaatcct ccgataaaaa tgagaacgag tccggctttg aaaccgcgtt tcagcctcac 3477001 gagcttttcg atataacgtc tgtagaatgc ccacccaaca gcaattaaaa tgagaaacgt 3477061 aacaatttcc tgaaaaaagg tgaaggcggg atagaccggg ccaagcgaca gattccggcc 3477121 gggagccagt cctttgatga taaagtcaat tgctccgaac tgaaccaata taaatccgta 3477181 gaaaaacatg acgtgaatga ttccgctttt cttgtccttg agcagttttt tctgtccgaa 3477241 tacattcacc catatggcgt gaagccgttc cttgaaccgt tgatcaaatt gttctttctg 3477301 gccgagcttg atgtaggcca gtctcgtttt gaccaagtaa acaaacaaat agacagcgta 3477361 agcggttaca atcagaaata ataatgcatt tgcgatgaga aagccgctca ttccaattcc 3477421 ccctttttac tgataaagac cgcgatcccc tacccccgaa tctgtataag attatcttta 3477481 tgataaataa tgaatgagtg ttcagtcaat aattaaattc ctgctgttcg ggcacactac 3477541 ctttactacg gaaaggagtg ccggtatgaa ggtatttatc gtgattatga tcattgtcgt 3477601 tattttcttt gccttgattc tgcttgatat cttcatgggc cgtgccggat acagaaaaaa 3477661 ggcgtacgag cctgtttttt caaaaaagaa gagtgacatc gaattgatcc actgcggcgc 3477721 tgatctcgtt gagcggatga tgaatgatat tcgccaggcc gcctcttctg ttcacatgat 3477781 gttttttatt atgaaaaatg atgaggtcag ccacaatatg tataccttgc tgaaaacaaa 3477841 agcccaagct ggcgtatccg tttatttgct tctggattgg gcgggctgcc gggcaattaa 3477901 aaaaacggcg cttcagacga tgaaaaatgc cggcgtccat gtccatgtga tgaatcgtcc 3477961 ccgttttcct tttttctttt ttcacatgca aaaacggaat caccggaaga ttacggtgat 3478021 agacggaaaa atcggttata tcggcgggtt taatatcgcc gaagaatatc ttggaaagaa 3478081 ggcgaagttc ggcaattggg aggattatca tctgcgcatg atcggagaag gcgtacatga 3478141 tcttcaaacg ctttttgctt ctgatctaaa acgaaatacc ggaatcgaac tgggttcgga 3478201 tgtttggcca aagcttcagc aagggactat ttctcacaag atctatgcga ccgacggtta 3478261 ttcccttgaa aacatatact tggccaacat tgcccaagcg aagaatcgcc ttacggtttg 3478321 cacgccttat tacattccat caaaaccgct tcaagaggcc cttattaacg caagaaaaaa 3478381 cggcgtatcc gtgagaatca ttgtaccgat gaaatcagac catccgctgg tacgagaagc 3478441 ggcttttacg tattattcgg agctcttgga tgccggctgt cttatttatc gttattatca 3478501 agggttttat catgtaaaag ccctcatcat agacgaccat ctcagcatta tcggaacagc 3478561 caacttcgat aaacggagcc tgttcttaaa tgaagaggtg aatgttgaaa ttgatgacga 3478621 agcgtttaca agtgaagtct atgccacaat tgaggaggat atgaaaaagt cggagctgct 3478681 gacgatggag gatttcagca agcgcacatt caggcagcgc ccggcggaat ggctcggcag 3478741 ggcattatct tatttcttat aaaggagagt tcctatgatt ttcagattcg ggttcgtttc 3478801 aaatgcgatg agcctttggg atgcgtctcc cgctaaaaca ttgacattcg cgcgttattc 3478861 aaagctttca aagactgaaa gaaaagaagc gcttctgact gtgacaaaag ccaatttgcg 3478921 caatacgatg agaacccttc actatatcat cggccacggc attcctttgt accgtttttc 3478981 cagttcgatt gtgccgctgg ctacgcatcc cgacgtgatg tgggattttg taacaccgtt 3479041 tcaaaaagag tttcgggaga ttggagagct tgttaaaacc catcaactgc gaacaagctt 3479101 tcatccaaat caattcactc tgtttacgag cccgaaggaa tccgtcacaa aaaatgcggt 3479161 aacagatatg gcgtatcact accgcatgct tgaggccatg ggcattgctg atcgctccgt 3479221 tatcaacatt catattggcg gcgcttacgg aaataaagac accgccactg cacaatttca 3479281 tcaaaatata aaacagctgc cgcaggagat caaagagcgg atgacacttg aaaatgatga 3479341 taaaacatat acaacggaag aaacgcttca ggtctgtgag caggaggatg ttccgtttgt 3479401 ctttgacttt catcattttt acgccaatcc agacgatcac gccgacctga atgtagcact 3479461 gccccgcatg atcaaaacgt gggagcggat cggccttcag ccaaaggttc acttgtcttc 3479521 cccaaaatcg gagcaagcga tacgcagcca cgccgattat gttgacgcca actttttgct 3479581 gccactgttg gaacgcttta ggcaatgggg aactaatatt gatttcatga ttgaagcaaa 3479641 gcagaaagac aaggcgcttc tccgcttgat ggatgaatta agctccatcc gcggtgtcaa 3479701 acgcatcggg ggcggtgcgc tgcaatggaa gtcataaatg tgcaaaaata ggtttacgac 3479761 ttgtcagctt tgggaactta ggctatataa gacaacaatc gatggaggag aaagatcatg 3479821 aaaaatatca agtctctgaa agtagccgca caggccttta ctttaagaaa tttgattcat 3479881 ctttataaaa tgtgccattc cggaagccac gaggtttata tttattcaaa gaaaacgatg 3479941 tgcaaaatca aaagcttaat tgagcttgaa acgttccgca tggctcataa tgaaaaggaa 3480001 tatctgatcg tagttgaagg aacaaaagca tcacagctca ttgaaaaatt ccaaaatctc 3480061 atcgagcctg ctgagagaga agcgctctaa cttacataca aaaaaggata gacatctgtc 3480121 tatccttttt cttatgctct tacataatgg agctgaaccg cttgtccaaa ttgttttgtc 3480181 ccttttaacc gcagttttgt ttcatttgtt agttcgtgaa acagcgggat gccgcttcct 3480241 aaaacgacgg gaataacagt gatgatgaat tcgtcgatgg catcttcttt cataaagtca 3480301 ttcacaagct ctgccccgcc agctatccag atgtttgagc ctttttcctg tttcaaacgg 3480361 gcagtgaagg ctctggctcc ctcattgata aacgtcacat gttcatcttg ataactgtcg 3480421 ggcgatcctg taaaaacata gcaggtttta tcctgatacg ggaaaaccgg tgttagcact 3480481 ttaacgtgct catatgtgct ccgccctaaa atgactgtat caacagtctg ataaaaatca 3480541 ctgtagccgt tgtcaccttc accttcaaat tcatccagcc aatcgatgct tccatcttct 3480601 tttgcgatca tcccgtccaa tgaaacagca atgtacagca cagtttttct ttccatgttc 3480661 tcctcctatc gatgcaccat ttgcccgaat tgcgcttgat gcagcctgct gtataggcct 3480721 ccggcttcga tcaggtcttg atgacggcct tgttcttcaa taccgttgtt tgtgacgact 3480781 acaattctgt ccgcgtcttt gattgttgcc agcctgtggg cgatgacaag cgtcgtgcgc 3480841 ccctcagaca actcttgaag cgccttttgg atcgccgctt ccgtctctgt atcaagggct 3480901 gaggtggctt cgtcgagaat caagatcgac ggatttttca agaacatcct tgcaattgac 3480961 agacgctgtt tttgcccgcc ggaaagcttc acgccgcgtt cgccaatcat agtatccaac 3481021 ccatcgggca tgttatggac gagctcttcc agatgcgcct gcttcacagc ttgccaaatg 3481081 tcttcttctg atgcgcctag tcggccgtag gcgatatttt ctctaagcgt gcccgagaat 3481141 aagaaaacgt cctgctgcac gacgccaatc tgcccgcgca acgaagaaag cgtcatgtct 3481201 tttatactga tgccgtcaat cgtaatgtcg ccctccgatg cttcataaaa acgcggaagc 3481261 agactgcaaa gcgttgattt cccagcacct gacggaccga cgaacgccac cgtttccccc 3481321 gcttgaatgg ataggttgat gtcattgagg acattgtgat ggtcatcata gccaaacgaa 3481381 acatgtttat agcggatatt gcccttcagg ccggaaacat ctttcgaatc aggtgagtcc 3481441 tgaatatccg gctctgtctc catgagctcc atatagcttt tgaaacccgc gatccccctc 3481501 ggatacattt cgataatggc attaattttg tcaataggcc tgaacagcac attcgtcaag 3481561 agtacaaacg ccacaaattc cccgtacgat aaggagccgc gaatgacaaa ccacgtcccg 3481621 cacaaaagga caaacagcgt gacaaaccgg gtcagcatat agctgattga accgtttttc 3481681 gccatgattt tgtaggaaga aagctttgtg acacgaaaac gctggttgtt gacggcgaag 3481741 cgttcttttt caaatgcttc atttccgaac gcctgcacaa gccggatgcc gccgatgtta 3481801 ttttctacac gcgcgctgaa gtctccgata tccttgttca gcgtggtaaa tgctttggtc 3481861 atttttttgt tgaaataaag cgctagccaa atgacgatcg gcataatgat aaacgttaat 3481921 aaagcaagct gccagttaat aaacagcatc actccgaacg ccccgagaat ggtcatgacc 3481981 gcaatgaata agtcttccgg tccgtgatgg gcgacttcac cgatatacat taaatcgttc 3482041 gtgagcttcg acatcagcgt tcccgtcttg ttgttgtcgt aaaatttgaa cgagagcttt 3482101 tgcaaatggt caaaaagcga ctttctcata tcagtctcaa tattgatacc aagcatgtgt 3482161 ccccagtagg tcacgatata ctgaagagcc gagctgagcg cgtacaccgc aaataacccg 3482221 attgaggtcg cgatgatcag tccccagtcc ctgcccggca gcaaggtatc aataaaataa 3482281 ttgacgatca aaggaaaact cagctccatt aaacctcccg cgatcgctga gaaaaagtcg 3482341 agaaagaaca acgttttata tggtttataa tatgaaaaaa attgccgcag caccctatct 3482401 tcccccaatg tataaataac tgataatatt tctcaattat actatacacg ggctgttttg 3482461 taagatcaga tttctttttt cttacagaac acctgaaaac aggcgggcaa acgactcttt 3482521 tgtccggtca gccacacctc ttttataaaa gccgacaggg ctgagctttt cactttcctg 3482581 catatcctct tcaaaatggg cctcaagggt tcggatcgct tcggcatccg tgaagaacac 3482641 attcacttca aagttgagct gaaagctgcg catgtccata ttcgcggtac cgacggaggc 3482701 gagatcgcca tcaatgatca tgactttttg atgcatgaag cctttttggt aggagtacac 3482761 ttcaatgccc tcaaggagca gctccgggaa ataggacctc gacgcgtatt gggtcaaaaa 3482821 gctgtcgttc ttctccggca ccataaccct tacctctacc ccctttgtcg ccgctgcttt 3482881 tagcgccgtg cgaatggatt cattggggac aaaatagggc gtggcgatcc atattgattt 3482941 ctgcgctgaa gaaatcattt cataataaag gtcgctcatg ctttccttca tgtcagggcc 3483001 tgtcgcgaca atttgataaa tgcctcctcc ttccacggga accggggtat tgtactcctc 3483061 ttgatcaatt agcacttcat tggagacata ttcccaatcc agcataaaga tagcgtggag 3483121 cgtttgcaca atttccccct caagccgcag gtgtgtatct ctccaaaatc cgatgtacgg 3483181 atctctgctg atatattcct tcccgacatt taatccaccc acaaaaccgg ttttcccatc 3483241 gatgatcacg attttccggt gatttctgaa attcagcttc tggttgaaaa acccgtattt 3483301 cagcggagaa aacgggacga tgtccacccc cgcttgtttc attctcataa tatctcttct 3483361 tgccagcttc atgcttcctg ccgcatcgta taaaaacctc acctcgacac cctggcgcgc 3483421 tttctccatc ataatatcca tcatgccgcg tccgagcatg tctgatttaa acatgtagta 3483481 ttcaatatgt atgtaagatt ccgcttttct cattgctttg aaaatgtccg ggaaggtttc 3483541 ttcgccgttt ttcagcactt tgatgttgct tttcgtattg atattcatat gggcagccct 3483601 gatggaatat gtaaagaacc tctcttgatt gtccttcagc cctgtcactt cgggcgtttc 3483661 ctccttgtca aacagcttcc tgagcttttc cctgttgtac attcgttttg tcttaaacag 3483721 ctttcccttt acataaagct gtcccgaaaa cagataaaac acgtagccga cgattggaaa 3483781 aaagacaaga atatggatcc atagcagcgt gtgctgcgag gtgcggtttt caagaattaa 3483841 tgaatagatg ctgaacaaaa taatgcttat atagcaaagc aatcctccgt aaaactcaag 3483901 tctggaaacc ggaaaaaacc aaatgacata tgccccgatg agcatcatat ataaaaagaa 3483961 aaattccagt ctccttttca gcatcctgat tctctccaat ctgattcaat tacctctgta 3484021 ttacctcttt tttctaatcg ataaaccttg taagtaaaaa acctctccgc caaaggagga 3484081 gaggtttaga gaaaactaac tgtcacggaa ttcatccgca tcgtttctgc agaaataaag 3484141 caagactatt ggcaacgccg agtgacaaca tgagcggcaa gctgaacccg ctcagcactc 3484201 cggcaagcgc cgaaaagaag gcggcgctgt gactgcaaat acggtggata gagtaaattt 3484261 gatacccatt ctgatgagag aaaatatata aaacgggaaa ttgatcagaa agatataagg 3484321 agttagtcag gctgaatcat aatctggctg ttccgccggt ttaaaatgag taaaatcctt 3484381 gatgttattt ccatatacaa acataacagg attcccggca gcccagccat taccttggca 3484441 gaaaaaaccc cctcttgcaa gggggatttt cacgagcgtt tccgatatac aacgtagctg 3484501 cgggtcagat acttgagcgg cagactgaac acatgaacca atctcgtaaa cggccacagg 3484561 ataaaaacga cgtatcctat cacaatatga aacttaaacc atagcgggac actctccatc 3484621 aaagaggcgt caggcctgaa caaaacgatt tccctgaacc agggcccgac tgtggtccgg 3484681 taatcaaatc ctttcgaatc aatgttgaga aacgtggccg caacgcctga cagcatcatg 3484741 aacagcagca ggaggagcgt aaggatatcg gatggcgagc tcgttttgcg gattcttttg 3484801 tcaaacagcc ttctgtacgt caggatgaca agtccggtac atgccgcaat gcccgccggc 3484861 aagccagcgc caatcgccat tttgtgatac atatgctctg aaatgccaag ggaagcatac 3484921 acgccttctg ggatcagaat ccccatgaca tgcccgccga caacgcacag cagtccccag 3484981 tgaaaaagtg tgctgccagc cgcaagtttt ttcttttcta acagctcgct tgatttcgcc 3485041 gtccagccaa attggtcatg ctgatagcgg taaatatggc cgccgataaa gattgtcaat 3485101 acaatgtatg gcataatacc ccagaggatc tgcccgctca tgcctgaaca gccccttcaa 3485161 cgctttcacg tacgccaatg ttttcaagcg cggccagcag cacgtgcagc agttcagcgt 3485221 atatactgtc atttttttcg agacgggatg ccagctccct cacattggac agatatttct 3485281 caaacacgct tctcgctgct tcaatttctg cagccgcagc aaattccagc atcagcggca 3485341 gataatcagg cagctctttc tctgtcggca ggaaaccgga ttgctcgtat gtgtttttta 3485401 aatgcagcaa ttcaatgccg cgttcccttt gctcgcctga gttaaagtag gtgacataca 3485461 tatttgtttt tttcccgaag tcgaatgtat agacatagtg ttcaatcagc gcttccggag 3485521 aatagctggc tgacgtctcg aaaaagtgca gcagcttctc ccggatttgc cggttgccga 3485581 tttcttggat aagagccttc caatcgggaa gctcggctct ccactcttca tccggataag 3485641 agagaagaca ggaaagagca gagaacgtga tttgccggtc tgtggtgttc atcttgttac 3485701 acctcattta tcaaaagtta gaaacaggag ccggggccgc ctgaaaatga taagccgcag 3485761 cttccttgtt cagcgtataa atctgatact tcttctcgat ggctgctcgg aatcacaaag 3485821 cggtcatcat atttggcaat cgcaagcagc cgatacatat cttcaatttg ctgttctgtt 3485881 aagccgacac tggagatcag ttccggatcg attgatttat tcgtctggac cgctctcata 3485941 tactggcgca tgacagacat tttctttaat gttgaccgaa tatgatccgt atcaccggct 3486001 gttaacagct gcgccaaata atctatcggg attctcattt ggtcgatagc cggaaaaata 3486061 tcttccgccg tttgccggct gccttttcct tcaaagagat tcataatcgg gctgagcggc 3486121 ggaatgtacc acaccattgg cagcgtgcgg tactcaggat gaagcggcag cgcgatcttc 3486181 cagtcaatga tcattttata gatcggtgat tgctgcgcgg cctctatcca ttcagccgga 3486241 atgccttgtt cttttgccag tttggcaacc tcaggatcat tcggatcaag aaaaacgtcc 3486301 aattgggaat ggtagagatc cttttcattt tcaacagatg ccgcttcctc cactttgtcc 3486361 gcgtcatata gcatgacgcc gaggtagcgg attctgccaa cacacgtctc agagcagatg 3486421 gttggcagtc ccgcctccaa acgcggaaag cagagtgtgc atttttccgc tttgttcgtt 3486481 tgccagttaa aatagacttt tttataagga caggatgaga cgcaatatct ccatgaacgg 3486541 catgcgtttt gatccacaag cacaatgccg tcctcctcgc gtttgtacat ggcgccggat 3486601 ggacaggatg agacgcatgc cgggttgatg cagtgctcgc aaatacgggg caaatacatc 3486661 ataaagacgt catcgaattc tgttttgatc gattcctcca tcttttgtac gttgggatct 3486721 tcaagtcccg taatgtggcc gcctgcgaga tcgtcctccc agttcggtcc ccattcgata 3486781 ttcatgaaat cccccgtcaa ggacgatttc gggcgtgcta ccggctggtg ttttttctgc 3486841 gggctgttcg ttaatgtttc ataatcatag ttccaaggtt catagtaatc atcaattgac 3486901 ggctgattcg gattatagaa aaggcctgca agccgattgg ttttcgagcc cgatttcagc 3486961 tcgagctttc cttttttcaa tgtccagccg cctttatatt tgtcctggtc ctcccattgc 3487021 ttcgggtagc cgatgcccgg ctttgtttct acattattga agtacatata ttccgcaccg 3487081 gaacggtttg tccacgtgtt tttgcaggtg acgctgcacg tgtggcagcc gatgcattta 3487141 tccaagttca tgaccatacc gatttgcgct ttaatcttca agccaatcga cctccttcag 3487201 cttgcggatg acgacgttca ggtcgcgctg attccccgtt ggaccgtaat aattaaagcc 3487261 gtagctgagc tgggcgtagc caccgatcat ctgtgtcggc ttgacgtgaa tccttgtcgg 3487321 gctgttatgg gtgcctccgc ggttattcgt cagctttgtg ccgggcacgt tgatgtggcg 3487381 gtcctgggca tggtgcataa acgccattcc tttaggaatc cgatgagaca aaacggctct 3487441 cgcgacgaca acgccgtttc ggttgaagca ttcaatccaa tcgttgtctt tgatatccgt 3487501 gtcctctgca tcatctttat tcatccacac ggtcggcccg ccgcggaaca gcgtcagcat 3487561 cggcagagaa tcaaaataca tgctgtggac agaccattta ttatgcggcg tcaaataatt 3487621 gaggacgatt tcttttccct cttgatcagg ccgtttgctc agaaacgggc gatgctggag 3487681 gatcggtttg aatgtcgcca tcgtttcacc gaattccatc atcagttcat gatcgacata 3487741 ataggattgt ctgcctgtca gcgtccgcca cggaattaat ttttcaacat tcgttgtaaa 3487801 cggcgaatac ctgcgccctc ctttttcaga gccggtaaac gctggagacg tgatcaccgt 3487861 tttcggctgg gctgtaattt gttcgaacgt aaagcattct tcctcgcgtt cttccgccag 3487921 gtctttcagc ttcaggttcg tgatgttttc aagtgattcc catgctttta ctgcgacctt 3487981 tccattcgaa gtggatgata gggttaaaat cgcttctgca gcctgctttg cttcacttat 3488041 atttggacat ccctttgcca cgctgtccga ggtgatttct cccagtctct gtttgagtga 3488101 ttcatattca tcggctattg accagctcat cccttttgtt ccgctcggct ttaaagcaac 3488161 gttcggacca agtgcagtca ttttatgaaa aatgtgtttg taatcccgtt caacgacttg 3488221 gatgttcggc atcgtttttc ccggaatggc ttcacattcg cctttgctcc agtcattgat 3488281 tttgccgaat ggctgggcca attcctgcat ggtgtcgtgg agcagcggtg tcgcaaccac 3488341 ttctttcacc ggctccatat cgacttcttc tgccagatcg gaaacggctt ttgacagcgc 3488401 cttgaaaata tcccagtctg acttcgattc ccacggagcc gagatcgcag gagcaaatgg 3488461 atgaatgaac ggatgcatat ctgtgctgct gagatcgtgt ttttcatacc atgtcgccgc 3488521 cggcagcacg atatcggaat acagcgccgt acccgccatt cgaaaatcaa gattgattaa 3488581 taagtcgagc tttccttccg gcgcctgctc ccgccatttg atttcttctg ggcggatgct 3488641 gtcgctgtcg tcattcatta aaccgttcgt tgtccccagc aaatgcttga gaaaatattc 3488701 atgccctttt cctgagcttg agatcagatt tgcccgccat acaaagagat tccttgggaa 3488761 attcacttca ttgtcaggat cttcaatcgc gaatttcagt tttttctctt ggagctgtga 3488821 ggccacgtac gcacctacgt cttcaggtgt tgctgcccct gctttttcag cttctttata 3488881 cagatcgatg ccattttgat tgaaagtcgg gtaagacgga agccacccta gccgcgccgc 3488941 cagcacattg taatcagcgt ggtgcttgta gcgggatgaa gcagcaatcg gtgatgccaa 3489001 atcactgatc ggctggtcct cataacgcca ctgatctgtc gcaaagtaga aaaatgaggt 3489061 gccattttgc agcttgggca cgccttccca gtcctttgca gttgcaatcg tctgccaccc 3489121 ttcagcaggt cggagctttt cctgccccac gtaatgggcc cagcctccgc cgtttacgcc 3489181 ttgggcgcct acaagtaaaa caagatttaa cactgctcgg tagatcgtgt cggagttgaa 3489241 ccagtggtta atgccggccc ctacgataat catggaccgg ccgtctgtat cgatcgcatt 3489301 ttgggcaaac tctctggcaa tcttaacgac agcttctttt ttgattcctg tcatttgttc 3489361 ctgccaggca ggcgtaaacg gctcagggtc atcataggag acagccgatc gttcgccgat 3489421 gccccggttc acgccgtagt tagccagtat caagtcaaac acggtcgtga tgtacgtttc 3489481 ttcaccgttc aggttcattt ttttaatagg aagatcccgc tcgagcactt tgtttccgtc 3489541 atttgaaaaa tacgggatgc gcaccgtgcc gatttcgtcc tctattccca gcacagagag 3489601 acggggttca atcggttccc cggtttcttc atcaatcatg tgcaggttcc atttctgctg 3489661 cccgtcccag cgcgagccca ttgtcccttg gggtatggca aatgaacttg tctgttcatc 3489721 ccaaaccgca ggcttccact gatcatgctt tgtcttccgc ccgatgtcct tcgcatgcag 3489781 aaaccgtccc gctgtgtata cgccattttc ttttgacaga gtgacgagaa atggaaaatc 3489841 agtgtattgc ttcgcgtact caataaaacg ttcagtttct tggttcacgt aaaattcctg 3489901 cagaataacg tgacccatcg ccatcgcaag cgccccgtca gtcccttggc gaatactcag 3489961 ccagtcatcc gcgaactttg aggattccgc aaaatctgga ctgatcgaaa tgaccttagc 3490021 gcctttatag cgggcctccg ccaaaaaatg cgcgtcaggc gttctcgtta acggaacgtt 3490081 ggagccccat gtgataatat agccggaatt gtaccaatca ctgctttccg gaacgtccgt 3490141 ctggtcaccc caaatttgcg gggatgctgg aggaagatcc gcataccagt cataaaaact 3490201 gagcataggg cctccgatta acgacataaa ccgggagcct gatgcgtggc tgatcatgga 3490261 catggccgga atcggagaaa aaccgacgtt tcggtcaggc ccgtatttca tcactgtata 3490321 cagcagagag gctgaaatca gcttcagcac ctccggccat tcagcgcgca caaaaccgcc 3490381 tttccctctc gcctgtttat aggacttcgc tttttcaggg ttttcgacga tcgatttcca 3490441 ggcttccaat ggattttgat gcgtctgcaa tgcctcccgc cacaaattga tcagcacacc 3490501 gcgcacgtat ggatatttca cacggagcgg gctgtagata taccatgaaa aactggcccc 3490561 ccgcgggcag cctctcggtt caaaatcagg catatccggg cctgttgatg gataattcaa 3490621 attttgccct tcccacgtga ctattccgtt tttcacataa atattccagc tgcaagaccc 3490681 tgtacagttg acgccgtggg tggagcgaac gactttgtcg tactgccatc tgtttctgta 3490741 tacattctcc caatcgcgat cctcgcgggt agtttggcta tgtttatttg aatggtgttc 3490801 gataggagag aaataattca atctcctaaa caacggactc cttttctttt tcttcatgag 3490861 agttcactcc ttccgagtca ggtgatgcta agttcactat aaacagagac agcgtgtttc 3490921 cttgtgaact atgtcacaca ctctgctttt ttcacaaaat gttcacacaa aggagaagga 3490981 aggctgcgtt caggcaggac gcttgggtca ttagctgcct ttcattcaaa gatcaaaaaa 3491041 aaccggctct atttaagaac cgggctcagc gttttcatcc tgtgatgtat gcagataccg 3491101 caaaaataat tgataggaac aaaaaacatt ttgctgaagc atagccaaaa agttcatttg 3491161 cagctgcgga tgataagaca tcattttctt aaatatgtaa tatgggatgt tgagaatcag 3491221 aatgtctgaa gtggcattga ctgagataaa gggcgataaa taaagcccgc ctttttcatc 3491281 aatcggaaac acatcgcctt tttcccacag cgcaacggtt ttcgaccctt cagggagcct 3491341 tgtgtccata aaacggacac tgccttttaa tacaatataa acagattgag aatgaagaaa 3491401 agatggagac tgatcacatg aaccgcggat aaacgtgccg tttttcagca aggtttcgac 3491461 aatggataga ggcacttcat taaacatagg aagttgtttc agaaataata aatagtcaca 3491521 ctgattcata ggaaaacctc ctgtgctaag gatagcttta gtgtagctcg actgagcctg 3491581 tacagcagtg atgtatttca cagcctgtat gatgaatgtc acttatcagg agggtgaatg 3491641 catttataat gaaagaaaaa aggaggattt cgatgaaggc gctgattccg aagcagcacg 3491701 gggcgtgggc gatgctgctg atcccatttt tactcggcat ggtcaaggga ggccccgtta 3491761 tttggcatat tccgctcttc cttggttggc ttttcctata cttagcggtt tatcccgtta 3491821 cgcttgcctt aaaaaagaaa caaagcaaac catatcaaaa gtggatgtgt tattacggtt 3491881 ttcccacctg ctgctttttg atgatctcgg tctttcataa gccgcctctc atctgggtgg 3491941 gcgtttcttt actgccgctg tttctcatac atatgtattt tgcccgcaga aaaaacgaac 3492001 gagccttatt gaatgatgtt gcaggtgtct tgttcttttg ttcgggcggg tttgcgagct 3492061 gctggctggg gatgggaacc cttgacggct gggcttggtt tattttcttg cagtctgctt 3492121 tattttttat cgggagttcc ttttatgtga aatcggtgat ccgcgagaga aaaaacaggg 3492181 catttgcata ctggtcatgg ggatatcacc tgctgctccc ctttttatcc gctcttttcg 3492241 gagcaggatg ggcgtttctc gcttttatcc cgagcagctt gcgggcatgg ttttttcatg 3492301 gaagggattg gcccgtaaaa acgattggca ttctggaaat cgtgaatgcc tgcttctttc 3492361 ttgccgtcat gtgcctgttt atcacaaggt aaaaaaacaa ggacaccgct gtccttgttt 3492421 ttttcagtca atattgcaaa tctccagcgg gcaattttca cactcaatct cacatcgtaa 3492481 atagtcccgc ttgtgcaaaa taatttttcc ggattcgtct atcgaaataa cccctttttt 3492541 gcggagatct ccgagcatac gattgacgct ttcccgtgca gccgcgcaaa actttgccaa 3492601 atcctgattt gtcaggacaa tgttaatcag aatgccgtcg cttcgctcca ctccgtagct 3492661 gtttgataag cggataaggg tagaatagag cgcccccttt ttgccatgaa gaagcagatc 3492721 cctgattttg gactgaatct tccggaggtg cgtgctcatc catttcatga actcaaatgt 3492781 caaagcgccg ttttggatta attctttttc cagcttattt ttattaatga cgagcacctc 3492841 gccatcctct agtacttttg cactgagcat ataccttggt tcttcagtga aaagtgttaa 3492901 ttctccgacg atatcatgct tttggcagat tctaagcgtc aggtcttttc cgtcagatgt 3492961 cagcttgccg atttcaatga gtcctgattg aatcagataa agctcttctg catccattcc 3493021 ttcccgaaac aaatacgtgt gtttttccat ttttcttttc gtgctgatcg attccagcaa 3493081 ttcatacaga tcgctggata taagatcact atcagatggt cgaacagaga gaaaattcat 3493141 gagctcacct cgaagaaagt cacgttgtgt gtttattgta acgtgaattg atttgtaccc 3493201 atcgagaaaa aactaacaat cttgtgaatg ccccagtgtt agttgatgct ctggctgttt 3493261 ctctccgtgt gtgttttcat tctttcctgc caatacatcc atatgacaag gacaaaactg 3493321 gctaacgcca cctctgaaag cgccataaac ccgatcgcgt actggcctgt tgcctgaaat 3493381 acactcgcca atatgagcgg aggaaaaaag ccgcctaaac cgcccatggc agacacaatc 3493441 ccattggcaa tccccgcttg cttcgaaaaa tagaaaggca ccagtttaaa aacagttccg 3493501 tttcctatgc ctgagcagac ggccacggtt aatgatccaa acgtataaag gccgattgtc 3493561 ggcgagaacg ataggataat gcctgataat gtaagcccgg caaaaacaaa catcaagatg 3493621 cggagcgggc tcattttatc agccaggaat ccgcccgcag gcctgagcag cgtagaaacc 3493681 gcaataaagc cagccgtccg caagccggca tctgcaggat tcagcccaaa atgctccacc 3493741 agaaagttcg gcagatagat agtgaaggcg acaaaggcac cgaacgtaat aaaataaaac 3493801 aggctcagaa accatagcac atgatttcgg taaacagctt tgatttgagt cttaacagaa 3493861 actttgacct tcttctcatg cctgtcgcca aacaatacgt gcagtaaggc aaagacagcc 3493921 agcaaaatca gatacatttg cacggttgat ttccacccga cggcttgagc gataaccggc 3493981 gctgcaaatg tcgtaacggc tgtcccgata tttcctgcac cgtaaatccc attgacgaca 3494041 ccgtgctttt ctttcggata atatttcggg agggaggtca ccccaatgga aaacaccgct 3494101 cccccgatcc ctaagaaaaa gccgcctgcg attaaatcaa acagagaatc cgcgatactg 3494161 atccaaaata caggaaataa aagcaggatg aagctgacca taaacatgag ccgcgcgcca 3494221 aacctgttcg ttaaataccc taaaggaatg cggagaagcg acccgaggat cacaggaatc 3494281 gcggtcacta aagaaatctc acccttgctt aaatgaatat ctaatgtgat ttgggaaatg 3494341 agtgatgaaa tcagcaccca aaccataaac cctgccacca agcttaatga ctgtaacgat 3494401 aattgaatgt gttgacggtt gatcatttgg cttgcccctt tcaatgattc aataatcagt 3494461 cttatcatac aaaaactagc caaacaggat tgtgaattac atcacacgtt tttctcataa 3494521 aaaaaggaca aagcccgaag actttgtcct tttgatcgtg attacatttt ttccggagcc 3494581 gatacgccga tcagctgaag cgcattgttc agcgtaattt gcgttgcctt cattaaagcc 3494641 aggcgcgcgc ggcttttctc ttcattttca gggtcgatga ctttctctgc gttgtagaag 3494701 ctgtgcagag cagaagccag atcataaata tagttagtga cacggtgcgg aattcgtttt 3494761 tccgctgctt ccgccactgc ctctgggaag ccgccgatcg ttttcagcag atcgtattct 3494821 ttttctgatt gaatatggct gaaatcaaga tctgccgccg gtttaagccc ctgctcttcc 3494881 ccttggcgaa gcatgctgca aatacgggca tgcgcgtatt gtgcataata cacagggttt 3494941 tcgttagatg ttgatacagc aagatctaag tcaaaatcca tatgggtgtc tgcacttcgc 3495001 attgcaaaga agtaacgcac ggcatccaag ccgacttctt caatcaggtc acgcatcgtt 3495061 acggctttac cggtccgttt gctcattttc attttctcgc cgtttttgta aaggtgaacg 3495121 agctgaatga tttctacttc aagcgttcct ttttcatagc ccagcgcttc gattgccgct 3495181 ttcatacgcg ggatgtagcc gtggtgatcg gcgccccaaa cgttgatcag cttatcaaag 3495241 ccgcggtcaa gcttgtcctt atgatacgcg atatcaggaa gaaggtacgt gtacgtgccg 3495301 tccttcttga tcaatacgcg gtctttatca tcgccgaaag tcgtggaacg gaaccaagtc 3495361 gcgccgtctt cttcatagac gtggcctttt tcgcggagcg cttcaagcgc cttgtcgatt 3495421 tttccatttt ggtacagtga agtttctgaa taccacacat caaacggcac acggaagttt 3495481 tccaagtcct tgcgaagctt ttccagctcg tatttcaggc cgtattcacg gaaaaacgcg 3495541 aggcgttcac tttcctcttc gttaacgaaa cgatcaccgt attcctcagc gagacgcttt 3495601 ccgatcgcaa tgatatcctc accgcggtag ccatcctccg gcatcggttt ttccaatccg 3495661 agtgcttcaa agtaacggac ttcaacagaa agcgccagat tgttgatttg gtttcccgca 3495721 tcgttaatgt agtattcgcg gcttacatcg taacccgctt ttgaaagcac gttgcacaag 3495781 gaatcgccga cagccgcccc gcgcgcatgc ccgaggtgaa ggtctcccgt cggattcgct 3495841 gatacgaatt ctacctgaac tcgttcaccg tttccgatgt tcgtttcccc gtatgcttcc 3495901 cctgcttcca gtacagacgg aatcagcttt gttaaatatt gattgttcat atagaaattg 3495961 ataaaacccg ggccggcgat atccagtttt tcaatcgaag ccttcccttt atcaaaatgg 3496021 gcgacaatct cttcagcgat ttgacgcggc gctttttttg ccactcttgc caactgcatc 3496081 gccatattcg ttgagtagtc gccgtgtgtt ttatctttcg gtgtttctaa aacaacattg 3496141 ggaatctggc tttcttcagc cagtcccgct ttcagaacgg ccgctttgat ttcttctttc 3496201 agcacgtcct tcatttgttc cgcaatgttc atgcgtgagt tcctccctca tacgtgatcg 3496261 tcatattatg taaatgctcc tgctcgtctc cgacatgcat gtcatatgcg atgctgatac 3496321 ggcctttttc ttcatcgaga tcagattgaa tcgattttgt gcttgttttc agctcaagct 3496381 caccaaatga cattttatat ttagcaattg tggaagctcc cgttacgaaa cgctgattca 3496441 ttttgacagc gcctgacctc atgaccagga cttcgccttc gcttactttc acaatcgttt 3496501 tgactttgcc taagtcgtgt tcttcataat aagatagata cactttattt tgttttacat 3496561 agtaaaatcc ggtggtgcgg aattcgatga cttcttggtt tccgtcatcc tcgatcacag 3496621 acttcacatg gagtgttatc ggtgtctctt gcttcattct gacacgtcct tttcatcatt 3496681 ccactttgac ttgaatagta taatcattcg gtttgtaaac ttcaactgct tctatcttac 3496741 catcattgct catcagattt gaagataaac ctcataaaaa gcatttcctt atatagaaga 3496801 gaaaatcata tcactaatta cctttaggaa atgttacatt tttccgaaat ctatcatttc 3496861 cttttcacat ttttttcaaa atatatgtat tgaattagta atttgatagt tttaagataa 3496921 aagtacaaca tagatctgct agaaaaacaa aaaaagggag gattcaatta tgaaaaaagc 3496981 tgtcattgta gaaaacaaag gttgtgcaac atgctcgatc ggagccgctt gtctagtgga 3497041 cggtcctatc cctgattttg aaattgccgg tgcaacaggt ctattcggtc tatgggggta 3497101 aggatctccc aaaagggcat agtcattcta ctatgccctt tttaagtaaa ttacaatttt 3497161 taactaaaat ctacctcttg gatatacata cacaaccgtt tttcatttga atcatatgta 3497221 taggggatgg tattttgttt atagagcaga tgtttccatt tattaatgaa agtgtaagag 3497281 ttcaccagct tcctgagggc ggcgtgttag aaatcgacta cttgcgcgat aatgtctcca 3497341 tttctgactt tgagtatttg gatctcaaca aaacggctta cgagctctgc atgcgcatgg 3497401 atggccaaaa aacagctgag cagattttag ctgagcaatg tgcagtgtat gatgaatcac 3497461 cggaagacca taaagattgg tattacgaca tgctcaacat gctccagaac aagcaggtta 3497521 ttcagcttgg aaaccgggcc agccgccata caatcaccac gagcggaagc aatgaatttc 3497581 cgatgcccct gcacgccacc tttgaactga cgcaccgctg taatttgaaa tgcgcccact 3497641 gttatttgga aagctcacct gaagcgctcg gcaccgtgtc gattgagcaa ttcaaaaaaa 3497701 cggctgatat gctgtttgat aacggtgtat tgacatgcga aatcacaggt ggagaaattt 3497761 ttgtccatcc aaacgccaat gagattcttg actatgtgtg taaaaagttc aaaaaagtcg 3497821 ctgtcttaac aaacggaaca ctcatgcgaa aagagagcct ggagcttttg aagacttaca 3497881 agcaaaaaat catcgtcggc atttctctag atagtgtcaa ttccgaggtc catgactcct 3497941 ttagagggag aaaaggctct tttgcccaaa cttgtaaaac gataaaattg ttgagtgacc 3498001 acggtatatt tgtcagagtc gctatgtctg tcttcgaaaa aaacatgtgg gaaatccacg 3498061 atatggccca aaaggttcgg gatctcgggg cgaaggcgtt ttcttacaat tgggttgacg 3498121 atttcggaag aggcagggat attgtccatc caacgaaaga cgccgagcag caccgcaagt 3498181 ttatggaata cgagcaacat gtgattgatg agtttaaaga tctgattccg attattccct 3498241 atgagagaaa acgcgcggca aattgcggcg ctggctggaa gtccattgtg atcagtccgt 3498301 tcggcgaagt acgtccttgc gccctctttc caaaggaatt ttcattggga aatatttttc 3498361 atgattccta tgaaagcatc tttaactccc ctctcgtcca taaactgtgg caagcgcaag 3498421 cgccgcggtt cagcgaacat tgcatgaaag acaaatgccc gttcagcggc tattgcggag 3498481 gctgttactt aaaagggctg aactctaaca aatatcaccg gaaaaacatt tgctcttggg 3498541 cgaaaaatga acaattagaa gacgtggtcc agcttattta ggagggaaac gatttgtcac 3498601 cagcacaaag aagaatttta ctgtatatcc tttcatttat ctttgtcatc ggcgcagtcg 3498661 tctattttgt caaaagcgat tatctgttta cgctgatttt cattgccatt gccattctgt 3498721 tcgggatgcg cgcgcggaag gctgactcgc gatgagcatt ttggatatac acgatgtatc 3498781 cgtttggtat gaacgggaca acgtcatctt agaacaagtg gatttacatt tagaaaaagg 3498841 cgccgtttac gggttacttg gggtaaacgg cgccggaaaa acgacactga ttaatacgct 3498901 gacaggcgtg aaccgcaatt tcagcgggcg ttttacactg tgcggaattg aagcggaggc 3498961 cggcatgccg cagaaaacat cagatcagct gaagactcac cgttacttcg ccgccgatta 3499021 tccgctgcta tttacagaaa ttacggcgaa ggactatgtg tctttcgtcc attcgcttta 3499081 tcaaaaggat ttttcagagc agcagtttgc cagtttggcc gaggcctttc atttttcgaa 3499141 atacatcaat aggagaattt cggagctgtc cttggggaac aggcaaaagg ttgtattgat 3499201 gacaggctta ttgctgcgcg ctcccctgtt tattttggat gagccgctcg tcggtttgga 3499261 tgtggaatcg atagaggtct tttatcagaa aatgcgtgag tactgtgaag caggcggaac 3499321 cattttgttt tcttctcatc tgctcgatgt cgtgcaaaga ttttgtgatt atgcggctat 3499381 tcttcacaac aaacagatcc aaaaggtcat tccgattgga gaggagaccg atctgcggcg 3499441 ggaatttttc gaggtgatcg gccatgaata acataatccc tatcatgtct ttgctgttca 3499501 aacagcttta cagccggcaa gggaaaaagg acgccatccg cattgccgca ggccttgtca 3499561 ttctggccgt gtttgaaatc gggctgatcc gccaggccgg cattgatgaa tcggtgttgc 3499621 gcaaaacgta tatcatactc gcgcttcttt tgatgaacac atatatggtg tttctttccg 3499681 tgacatcaca atggaaggaa tcttatatga agctgagctg cctgctgccg atttcttcac 3499741 ggagcttttg gctcgcccag agtgtcgttt tgtttgtcga tacctgtttg agaagaactt 3499801 tattcttttt tattttaccg ctgttcttat ttggaaacgg aacgctgtca ggggcgcaaa 3499861 cattgttttg gctcggcagg ttttcgtttt ttaccgttta ctccattatt ttcggagttg 3499921 tgctaagcaa ccacttcgtc aaaaagaaga acttgatgtt tctgctgcat gcggcgatat 3499981 tcgcctgtgt atgtatcagc gccgctttga tgccggccgc cacgattccg ctttgcgcgg 3500041 ttcatatcct gtgggcggtg gtcattgact ttcctgtctt tctgcaggcg cctccgcagc 3500101 agggcaagat gcattcattt atgcggcgat ctgaattttc gttttacaaa agagaatgga 3500161 accgatttat ctcttctaaa gcgatgctgt taaattacgc ggtaatggcg gtattcagcg 3500221 gcttcttttc gttccagatg atgaacaccg gcatcttcaa tcagcaagtg atttatatcg 3500281 tgatttccgc gcttttgctc atctgctcgc cgatcgccct tttgtattcg attgaaaaaa 3500341 atgaccggat gctgctcatc acgcttccga tcaagcgaaa aacgatgttt tgggcgaaat 3500401 atcgctttta ttcaggccta ttggcaggcg gatttctcct tgtcgtgatg attgtgggtt 3500461 tcatcagcgg ccgttcgatt tcagttctca cttttttgca gtgcattgag ttgctgctgg 3500521 cgggagcgta tatcaggtta actgcggatg aaaaaaggcc ctccttcagc tggcagacgg 3500581 agcagcagct atggagcggt ttctcaaaat atcggtctta tctgttttgt cttcccctat 3500641 tcttagccat attagccggc accgctgtat ccttggcggt cattccgata gccggtctgg 3500701 tcatagtcta ttacctgcaa aaacaggatg gtggtttctt tgatacaagc aaaagagaac 3500761 ggcttggaag ttaacctgct gaagactcat caattttcaa ctatttcaat cgccgcgagc 3500821 tttctgaaac cgatcgaaag cgcggcggaa cctgaggaag aaacgattta tttttacggc 3500881 gccgccgcat acctgaagga gcaaatcatt gacgcttttg gttatgctgc cggcagccgt 3500941 ttcatgtact cagcgaatct cttttttgat cagcagctga aaacctgcgg gacccgtttg 3501001 attcacccat tatataacgg gaatcttcat gttgacgccc tgatgaaaac ttttgcagac 3501061 ttgtctttcc cttcttctct ttcattcgaa gcatttgaaa aggccaggaa tgagctgctg 3501121 ctgaaaatcg aaaagaaatt cactgatccc ttctcctact cggcggctcg cttggctgag 3501181 gaggtcttcg gaaacccgat gtacggcaca ggcatgtttg gccggagaga caggataaag 3501241 gcgattcatc ctaaacggtt tctcgacgca acggacttta tcgttgattt agtgtcccag 3501301 caaaaacagc tgaacatatt gggacaagta caagcatgtg atgttcgggg acatgccccg 3501361 caaacgtccg ctgtaacgtc cggaagaata cccgtaaacc ggcatgtttt tgaaacagag 3501421 acacgcagcg ctgcaggtcc ttccgtcttg acactcggat ttgactgcgg agagatgaaa 3501481 gatgccagcg attatatcaa aatacagcta atagacggat tactgggaaa gtacggccat 3501541 tccgctttat tcaagcactt cagagagaag gatctggcag tctatcacgt tatcacccgt 3501601 tacgatgtca tgaacaattt gctgcttgtt tcaatatgta cagatcagct tcatgagaaa 3501661 gacattcccc cgcgcgtttt ggaagctgtc tcagcttttc atacagatga gcgggaacta 3501721 gaacaggcaa agcagttttt acgcaatgaa ttgctgctgc aattcgattc tcccgaaggt 3501781 ctattggcct atatgggggt cctgcgccgc ttctcctgca cgaaagaagc cttgctggat 3501841 ggcatctcag cggttacatg ccgtgatgta ttgcaattca tagcgaccat caattatatc 3501901 ggagctcatg tagtaagggg atgaagagat ggaaaagaaa gccttttttc aacagctgga 3501961 tgaacgaacc gatatcagat acacagacag cggactaaaa atattcagat tgaaattccc 3502021 ccgcgcccac ctgcggctgt gcaatgtaaa aatcgatttt ggaagccggg atgtatgtat 3502081 acgggcagaa tccggtgata cactgcttcc gtatggcaca gcacattttt tagagcatct 3502141 tctcttctgg cataacggcc gcaatctgta cagtgatttt tttgcgcatg gcgcgctttt 3502201 aaacgcattc actacctaca ccgataccaa tttcatgttt acctcattac cggatcggct 3502261 cagacaaacg attcccatcc tgcttgatgc tttatggaac cactcatttg acaagaagat 3502321 tgtcgctcag gaaaaagctg tgattacaag cgaaattcaa acagcacacc ttaaccatca 3502381 gctctcatat cattatcagc tgatcagcat gctttctccc tcctcaccag ctgccgtttt 3502441 ccccgcaggc agaatcgaag atattgaggc gctggacatc agtgatttac aaaaagccta 3502501 taaggctgcc taccaagccc atcggatgac gctgtttttg attgggggct cagaaaatac 3502561 agaaacgctt ttgcctcctc acctccagct ggaaaagcgt ccggattatc atgctgaaag 3502621 aaaaatcatc ccggcatgcc ctccagtcct ctcacaaaaa atgatgctgg gtgatgagga 3502681 gcggatggaa gatacctgga ccggattaca gatcggcgca cttcccgggc aaaacgatct 3502741 gttgtcgata aagctttatt gggatatcgc ggctcgtatt ctatttcaat tagattcacc 3502801 gttttttcaa gagattcagc aaacgtaccg cctggaaatc gatcgcttgt cagccgagac 3502861 ttatatatat gaggatggcg gtttcttgat ccttcacagt caagggaccc attcttcagc 3502921 ttatatcgat gtggcttcat actatgtcac acagaagaaa gaacaggttg ccgcctggct 3502981 tcaatacggc aaggactctt tgacagacgc gatcatttat gacagcgatt atgtgcgtaa 3503041 atgcttcgag tgggcagccg agtgtgacag gtgcgattgc tcgtttcttg acatgtacca 3503101 catcattcaa gatatggatg cgcaggtttt cttgtctctc attgatgcaa tggcatcttc 3503161 taacaaagcg atcattcacg tttctcagaa agaggcgatc agacaatgaa acaaagcact 3503221 gtctttaccc ttttattgct gcttataggt atggcggctt attccttcgg ctgggttcag 3503281 gccgttgccg aagccgccgc ccaatatgta cagatgatca acaatgatgc tgtgcggctc 3503341 ggactgctgg cttgtaccgc tgccctcctg atgctgcctg cttttctcta tcttcactat 3503401 gtcacccaat ccgtgaaaaa catgacagca gcttttcaga aactcacaca gtctcatcaa 3503461 agctgctgtg actttcagca acacaacttg tgcagccgat atgcagaaga cgtcaaatcg 3503521 ctgcgtgaca gctataaaaa cgtccgccaa acatacgtga tggctgccgt gttgtgccaa 3503581 gtcatcatat tcggctgcat gttcgaaatc gttaaagccg tccctttccg ccttcatacg 3503641 ccccctgcct tttcaatggg acttgcgatg ctactgatcc tgtatttatt gttttgcatg 3503701 cgaacgtatt tgcggcagct tttccggcac ggcagcctgt tcagaaaagt gtttgcggga 3503761 gcactggcag cagccgggat ttggtggatg ctcagtttct ctataagtga actgctgttt 3503821 ctgattatcc tggctgccat tcagcaaatc ggatcattta tttataaacg attctcttat 3503881 cacagcaccg cttctcttga tctataaaat agctacatcg caatcgcaga cggacccgcg 3503941 ccaaccggaa tcaccgtcac ggctgtataa tcacttgtgc ggtacacggt cacagcattg 3504001 tcgttgggct gtgccgcata aatatactgt ttgtccggcg ttacggcgag gtcaaaggcg 3504061 ccggggagag acacgtttgc aatgatcctc tgtctggccg tattaactac gtataagtta 3504121 ttaatgagaa acggttcact atatggctct agaaaataag ctctagtact atcgagagaa 3504181 aatacaatcg tcctcagcgt ttcaaataaa cggctgaagt cccctcccct gcttaatggt 3504241 gacaaactaa tctccgttac acctttcggc cacagctcac cattcaatac gtacgcaaaa 3504301 tttccagcgt aaggagttgt aattaaactg ggaaattcaa atgtatctat gatactttct 3504361 accaactgcc cagtatttac atcatattta tcaaccgacc aactgcttcc attagcggta 3504421 tagacatact gtccattcgg atcaagagca aagtctaaag cgccgggtat cggaatgaca 3504481 tcaatgaccg attgagaggc cgtgttaatc acatatatag atccggcggc catcacgtat 3504541 gcgaactcat ctgttggatc aaattcgatt tttctcggcc ctcctccaac agtaatggta 3504601 tttatgatgg ttaatgtttt attatcaatc actgagacaa ggttggtatt tccatggagg 3504661 acatacgtga atgctttatc gaaagtaacg cctagattag ttggcacgtc agaaaaaggg 3504721 attgttttta caacagtgtt taaatctgca tcaataaccg aaaccgtgct gtctccagta 3504781 ttggcagtaa acacatacga ttgagggtct ggtgatggcg gtaaaacaag tgtcccggcc 3504841 accgtaagcg gactgccgta gaaaggcggt acaatgagca gatcttccac tgttatttga 3504901 ctgaaatcag gacagcggcc agactgtgct gcataataaa caacttgatc aatctcttca 3504961 gtatgaatca cagaaacagc cccgtctcct tgtccatatt gatttcgtac aggcgacaca 3505021 ctgacaagaa gcgtaatggt cccttgtact ctcacagcat atcgaacacc gatatcttct 3505081 ggttccggcc cagtctggat taagcaaggc tcactgatac aggacaaatt gtctgtactc 3505141 catgtaacag ccgctgacgc ttcggccgta tcaaccttga agccctcagg gaaatctatc 3505201 ggcacttgaa acggcgcttc ccggctaatt tcctcatcac aaaaacagaa acaattttcc 3505261 tgtaaagcag aaagatcatt ctttttcatg atttcacgtc cttttagaaa tgcacaacat 3505321 gcagcggtta aatcgtaatg gcacccggtg aaaccccaag agatatcaca gtttcctcag 3505381 aataatcatc tgtgttgtaa acaatgatgc tctgctctat aaaacgagtt gcatacagaa 3505441 aatcgccatt cggggtaaac gcatagtctg ttgctgattg cggaacattt cctataacgc 3505501 ctgctccatt tggactgaca gaatataaat tgccagtgaa gccgtcatat aaatacacct 3505561 ctgctccact cgtaaacatt cgatattccc cttcatactc cagctcttgg gtgctgctga 3505621 tggtaaacgt atttaaatca ataaccgtca aataattaaa aaagaattct tgttctaata 3505681 cataggcata ccgctccggc caatttgttt ctatggttga tacgataagc tctcgttcaa 3505741 ttgttcctgt gacttcaccg gtagttaggt ccactttttg cactattcca aaattcagaa 3505801 cataggcgaa taacccattg ggatcgattg caacatcata tccttccaca ggaatcgacc 3505861 tatccacagt taacgtatca attccaatca cataaaccgc agtaccggtg aaaacataag 3505921 caaactcatg attagggata aatctaatca atcgaggcgg ctgatccagc aatatagttg 3505981 ctgtcactgt taatgtgtca taatcgatga cagaaatcac attattgttg ggatgtaaga 3506041 caaacacagc gcttttatct ggcgtaattt caatacctgc cggattgtac ggaagagcaa 3506101 tcgttgtcac aacagtatcg gtgtttgtat caatcacaga aactgattga tcatttggat 3506161 tcgctgtaaa cgcgtagacg ggttccggct ccggtacaag cacaattgtc cccgtcaccg 3506221 ataaaggact gccgtaaaac ggcggaacaa caacaaggtt ctcaatcgtg atgtcactga 3506281 tatccgggca atcatccgat tcatcggaat aatagacgac ttgatcgatt tctgcattgt 3506341 gaatgacgga aacagccccg tccccttgtc catattgatt tcggacaggt gagacactga 3506401 cgagtagcgt aacggttccc tgcaggcgca ctgcaaattg aacaccgacc tcatcaggct 3506461 caggccccgt ttgaattaag caacggtcac tgacacaaga aaggctgtct gcattccacg 3506521 tcacgtttgc aacagcttca gccggatcaa cgacaaaccc ttcaggtaat tcaatcggtg 3506581 cttgaaacat ggcttctcgg cttgcttctc cctcacaaaa acataagcac tcttcttgtt 3506641 ctgctcctgc tttttcttta aaggaaagct tgttttttct cattccttca cttccttttc 3506701 agacatacac tgctcacgca gatataacag aatatggaag ggtaacgtgt ttgcttgtac 3506761 aaattgctga gggtaaacgc ttctttttga aaatatatct ccaaacatgc ggtgtaacga 3506821 aagaaaaaat tgcggttttt ttgcgcttct cacaagaatg ttgatgataa aatatgacat 3506881 atatagaatt atgaagggag ggatttgcaa acgtgacagg tgtcatatct tcttcttcca 3506941 tcggagaaaa gattaacgaa tggtatatgt acatacgccg attcagcata cccgatgcag 3507001 aatatttgcg acgagaaatc aagcaagagc tggatcaaat ggaagaagat caagaccttc 3507061 atttgtacta ttcactgatg gagtttcggc acaacctaat gcttgagtac cttgaaccgt 3507121 tagaaaaaat gaggattgag gaacagccga gactgtctga tctgctgctt gagattgata 3507181 aaaaacaggc tcgtttaact ggtctgcttg agtactattt taacttcttc agaggcatgt 3507241 acgagctgga ccagcgggaa tatctgtcgg ctattaaatt tttcaaaaag gccgaaagca 3507301 agctgatatt cgttaaggat cggatagaga aagctgagtt tttctttaag atgtctgaat 3507361 cttattacta tatgaaacaa acgtattttt caatggacta tgcacggcaa gcatatgaaa 3507421 tatacaaaga acatgaagct tataatataa gattgctgca gtgtcattct ttatttgcca 3507481 ccaatttttt agatttaaaa cagtatgagg atgccatctc acattttcaa aaagcttatt 3507541 ctatggcaga agctgaaaag cagccccaat taatggggag aactttgtac aatatcgggc 3507601 tttgtaaaaa cagccaaagc caatatgagg atgccatacc ttatttcaaa agagcaatag 3507661 ctgtttttga agaatcaaat attcttcctt ccttacctca agcgtatttt ttaattacac 3507721 agatccatta taaattagga aaaatagata aagctcatga atatcatagt aagggaatgg 3507781 cttattcaca aaaggccgga gatgtaatat atttatcaga gtttgaattt ttgaaatctt 3507841 tatacttatc aggcccggat gaagaagcaa ttcaaggatt ttttgatttt ctcgaaagta 3507901 aaatgttgta tgctgatctt gaagatttcg ctattgatgt ggcaaaatat tatcatgaac 3507961 gtaaaaattt tcaaaaagct tctgcttatt ttttgaaggt ggaacaagta aggcaactta 3508021 ttcaaggagg agtgagtttg tatgaaattg aagtctaaac tattactctc ttgtctggct 3508081 ctaagcactg tgttcgtggc aacaactatt gcaaatgcac ctacacacca aattgaagtt 3508141 gcacaacgag gaatgattta accgccgtcc atcggcggtt ttttcgtccc ctctttacca 3508201 aagtctccca atccatgcta tgatcttttc aataatcttg aagagagtgg aaatgcagca 3508261 tgtctctaaa aagtgtgaga acccacttta ctcaatggaa tcgagaaaat gatgtgacgg 3508321 agttcgaaac gtcgagtgcg acagttgaac aggcagctga gacaatcggc gtaagcctgt 3508381 ctagaatcgc caagtccctg tccttcagag gggaaggaga tcaggtgatt ctgattgtgg 3508441 cagccggcga tgccaagatc gacaacaaaa agtccaggca aacatttggc tttaaagcaa 3508501 gaatgctctc tcctaatgag gtgctggagc agacaggcca tgaaattgga ggagtttgcc 3508561 catttggatt ggctcatgat cctgaggttt atcttgatgt atcgctgaaa cggtttcaga 3508621 ctgttttccc cgcatgcggc agcagaaact ccgctattga attaacaccg aaagaattat 3508681 ccgaattttc tttctcaaaa gtgtggattg atgtttgtaa agactgggaa taaaaaaaca 3508741 tccagacatc gtctggatgt ttacttattt cacaaaccca agcagcattt cacggatgat 3508801 tttgctggct gtgtttgccg tttgctctga gtggtcgtat accggcgcga cttccactaa 3508861 atcagcgccc tttacgttta cctctgaacg cgcaatttca tggaccgatg caagcagttc 3508921 tttagacgtg atgccgccgg cgtcaaccgt tcctgtaccc ggtgcgtgtg cagggtctaa 3508981 tacgtcaatg tcaattgtga cataaaccgg acggcccgcc agcttcggaa gcacctcttt 3509041 cagcggttca agcacttcaa attttgagat gtgcatgccg ttttccttcg cccattcaaa 3509101 ctcttctttc atgccggaac ggattccgaa tgaatacaca ttgtgcggtc cgatcaattc 3509161 tgccgcctta cggatcggcg tggagtgaga aagcggttct ccctcataat caacacgaag 3509221 atctgtatgt gcgtcaaaat ggataatcgc aaggtctggg tatttcttgt acatcgcttt 3509281 aatgacaggc catgacacga ggtgctcccc gcccataccc attgggaact tccctttttc 3509341 taaaatgctg tccacgtact cttcaatcat atccaggctt cgctgcggat ttccgaacgg 3509401 cagcggaatg tcgccagcgt caaagaagtt caagtcagcc agatcgcggt ctaaatatgg 3509461 gctgtattcc tcaaggccga ttgacacctc acggattctg cttggaccaa agcgtgagcc 3509521 cgggcgatag ctgactgtcc agtccatcgg catgccgtaa agaatggcgt ccgcctcttc 3509581 ccactcggga cggctcgcga taaatacttt tcctgaataa gcttcatcaa atctcatcta 3509641 taataccctc gctttcctgt aaaaaagcgc aagattcgct cctgcgccat accttcatta 3509701 tttaatcagg tcactcacaa atttcggcag aacaaacgcc gctttatgaa tatcttttgt 3509761 gtaatatttc gtctcaatat cgaagaaacg gctgtcttcc actgcaagcg gatcatattt 3509821 tttcgagcca attgtaaatg tccacaaacc gcttggatat gtcggaatgt tcgccgtata 3509881 cagcttcgta atcgggaaga tttccttcac gtcgcgctgt acatttgtga ttaattccgg 3509941 tgtaaaccat gggttgtccg tctgcgcaac gaaaataccg tcttctttca gcgcttttgc 3510001 gattcctgcg tagaatcctt ttgtaaacag gtttacagcc ggtccgactg gttcagtcga 3510061 atctaccatg atgacgtcat attgattttc agattttgca atgtgcataa atccgtcatc 3510121 tacctgcacg tcaacgcgcg gatcatccag tttgcctgcg atagaaggaa ggaacttttt 3510181 agagtattcg ataaccttgc cgtcaatatc tacaagtgtc gcttttttca cgcttgggtg 3510241 cttcaggatt tctctgataa cgccgccgtc accgccgccg actacgagaa cgtgctccgg 3510301 atttgggtgc gtgaataatg ggacatgcgc caccatttcg tgataaacga attcgtcttt 3510361 ttcagatgtc atcaccatgc cgtccaaaaa aagcatgttg ccgaactctt ctgtttccac 3510421 catttctaaa tgctgaaact ccgtttgttc tgtatgtaac gtcttgttaa ccttcatcgt 3510481 aatgccaaag tttttcgtct gcttctctgt gtaccaaagt tcgctcaatt gtcatctccc 3510541 tttcgaggct gtattcattt attgtaagcg tcttatcagc ttttattctc ggttgaaatc 3510601 tcattttcac ctaaggaaaa agtatagagg atggcgggga aaaagtaaag atgcgtcctg 3510661 ttctgcgatg tttaaaaacg atcttttttt ctcataatag tagaaacata aaaaaagggg 3510721 gaacccgttg tggatgcaat gacaaataaa cggctgagac tgacgctgaa aaccgttcgc 3510781 gcctttatct ttttaggggc ttttgcggcc ttggcggcag ctgctgtgtt tatgactgtc 3510841 attttgatag ccaaatacca gggcgctccc tcggtgcaag tgccgcaatc cacgattttg 3510901 tacgcgagtg acggctcaaa gctcggggaa acgaactacg gcgaaaagcg ctattgggtc 3510961 cccttaaagg acatgaatcc gacgatcgta aaagcgacag tggcgattga agaccagaat 3511021 ttctacgatc atcacggctt tgattataaa cgcatggccg gcgcggcgct tgctgacctg 3511081 aaagcatttg ccaaggttca gggtgcaagc accatcaccc agcaatatgc gagaaactta 3511141 taccttgaac acgacaaaac gtggaaacgg aaatggaatg aggcgttcta cacgatccgt 3511201 ctggaacaaa actattctaa ggacgagata ttagaaggct atttaaatac gatttactac 3511261 ggccacggcg cctacggcat tgaagcagct tcccgcctgt atttcggcaa gcatgccaaa 3511321 aacctgacgg atgcggaggc ggcgcttttg gcaggaatcc cgaaaggccc ttccggctat 3511381 tcaccgtatg tcaatgagac gaaggccaag gaacgccaga aaacgattgt gcggatgatg 3511441 gaaaagcagc agatgatcag ccaaaagaaa gcggatgaat tgatcaagga acctctttcc 3511501 tatcagcctt tgaataaaca agtttccaag agaaaggctc cttatttcta cgacaatgcg 3511561 atgagagagc tggaaaaaaa gctcggcatg acacgggagc aaattgaaac gagcgggtta 3511621 aacgtctata caacggtaga taaacggatg cagcgcatcg ccgaggagac cattaccgaa 3511681 acggttaacg cgggctctga cattcaagtc gggttttcag ccattgatcc ccgcaccgga 3511741 aacgttctcg cccttgtcgg cggcagggat tatcaaaaaa gcccgtttga ccggacgaca 3511801 caggcgaagc gccagcctgc ttcgacgatc aagccgttgc tgtactataa agcgattcag 3511861 agcggattta cgccagtcac tttgatgaaa agcgaagaaa ccgagtttca aattgatgca 3511921 aagggagaaa cctattctcc aagcaactat aacggatact atgccaacaa gccgattacg 3511981 cttctgcagg cgctggcgct ttccgacaat atttacgctg tgaaaacgca tctttttctc 3512041 ggcacgaaca aacttgtaaa gacggcaaag gaattcggca ttaccgccca tcttcaagca 3512101 ctgccgtccc tggcactcgg caccgaaccc gtacgtccga ttgagatggt caacgcctat 3512161 gccatgctcg caaatggcgg aaagaaaatc gaaccgactt ttatttcaag agtaacggac 3512221 gcagccggcc acgtgctgta cgaaaacccg aatcagcata aacaggtgct tgatgaaaaa 3512281 gccgcttttg tcacagcgag tatgatgaca ggcatgtttg atatcgattt aaatggatat 3512341 acgtcggtta cggggcgaac gatagccaac cgcctgacaa gaacgtatgc cggaaaatca 3512401 ggaaccacca gcgcagacag ctggatgatc ggcttcaatc cgaagctggc cgccggtgtt 3512461 tggaccggct atgacaaaaa cagcaccatc gactcggtcg aagaaaaaag ctatgctaaa 3512521 accatttggg cggacttcat ggaggacgcg ctcaaaggcg aaccggaaac cgcgttcaag 3512581 ccgccaaaag gcgtaaccgg tgtgtacatt gatccggaaa caggctactc atcaggtccc 3512641 ggctgcgccg ctaagcatta cacatatttt gtgaaaggga cagaacccgc aaacgtgtgc 3512701 tacggggcag aacccgcaaa acaaacaaaa gaccggcttc catccaaaga aaagcccgct 3512761 tccgagaaaa agtggtggga caaatggctg gggcgacatc attgaaaata acccggctcc 3512821 tcggaggccg ggttattcgt atggttcctt cataatcgat ggaagaatgt tagacaatcg 3512881 agctgaacaa tcagttttgg gataaagtgg tgaatttctc atttcttcgg cgctggcttt 3512941 catctcccag tcgccgactc atatccccct aaaaatgaaa aaccccgagt cttgtttcgg 3513001 ctcgggattt tccatgtcct atttctgtat caccagttta ctcaatgttt acgaaaaata 3513061 tctcaaatac tttaaaagtt cacaaaaaat tcataaatta attgttttct ggaagcaggc 3513121 tcgtttttaa ctcatctgag gaacggtccc ataggccctg atcatgcttt ttcagaaatt 3513181 cgcctagtac acgcttcgag ctgtcgtcca ttttatcaac gatgattttc cgtttcatgg 3513241 atttatccat cagattcaca tgctcaggca gtgacttgta gcctcttctg atgcttctgt 3513301 cgaccgtcat ttcacaggct gtcacaccag cgtaataagg cccctcttct tttctgtcaa 3513361 tcgttaccca cacaagccag tatggttttc cgttcggcac ttcttcttta ttcgggagaa 3513421 atttaattcc tttttcaacg gtgctgcggg catgcatagc gccgatgtct acgaacgctt 3513481 ctttttcctc tacatcaacg aatacgggag aaatgttatc aaggctgagt gcccctacgc 3513541 caaaaccgcc gtgtccgtct gtcggatcac ttttgataat attaaacccg attgattttt 3513601 tctttttttc ttccatgaag ttctacctcc tacaaaagcg gttgaaatat cgctgaaaac 3513661 agctttaaaa tcgaatctct tcctgcattg agcatcggcc acagcacgta agatcctagc 3513721 ggtgtcacaa acagcaccaa aaatacgata aagccgtagc tctccgcctg cgtcattttg 3513781 gcacgcacgc ccggcggaac gagatcttct ataattcgat agccatcgag cggaggaagc 3513841 ggcagcagat taaataaaaa caagacaaga ttcagctgta tccaaataga aaaaaactga 3513901 tccagccccg tgctgaacgc cgcaagcatt tccattccgt acgcatgcat caacactaac 3513961 aaaaagaaac caataaacgc aagaatcagg ttactgacgg gcccggctat agatacgagc 3514021 acaccagcaa gccggggttt cttaaagaaa cggcgattca cgggaatggg gcgcgcccac 3514081 ccgaatccgg ccaccagaat caaaatggtt ccgaacggat caaggtgttt aatgggattc 3514141 agcgtcagtc ttccttgttt tttcgccgta tcgtcaccga atttgtatgc gacataagcg 3514201 tgggcaagct cgtgcatcgt aaacgacaca attagcgtga tgacgaggta tggcattaaa 3514261 gataacggat aatataaaaa acggtccaag tgagatatcc ctctttctca aaatgcaaga 3514321 atttacttta ttcagtatac tataagaagc ctctttttct aaagagagga aacgagataa 3514381 aggaggattc agcacccatg ccatacgtaa ctgtcaaaat gctcgaaggc cgtacagacg 3514441 agcaaaaacg caatcttgtc gagaaagtaa cagaagccgt aaaggaaaca accggtgctt 3514501 ctgaagaaaa aattgttgtc tttatagaag aaatgagaaa agaccattat gccgtcgcag 3514561 gcaaacgcct gagcgatatg gaataatctc tataaagccg gcgcttcgcg caccggcttt 3514621 tattatccct attgagccag cttcgcaata atcgccaaga acgtcttttt ctcttcggct 3514681 gttaaacgtt caaacatgcc atcaatcagc tgctggcggt tttcgatcat ttgttcagcc 3514741 gctccccggc ccgattcaga aagagtaatc catacagtgc ggcggtcatt gttatttctg 3514801 gatctctcaa taaacccttc ctgctctaaa tgattcagag ctgtggtcgt ggcagaggga 3514861 gacagtgtga cctccttcaa aatatccttt atggtgcagc tcccatgtct gtatatgatc 3514921 cgcagaataa accctcttac attattcacg tgtttcggaa cggtggcttc atctaattgc 3514981 ttcgtgcttt tcaaatactt tgtaagtgcg tgatccagca aatttgcttc cagtttgtca 3515041 tggtccatgt caatttcccc atttcgagat gcattcataa catacgaacg atatgattta 3515101 cttattattt tactgattcc gaatagggaa agtcaaaaaa gcaaaatgtg aattcacagc 3515161 ttttatccta catgcctcga ttttccacct gtttcacaag tttatcttta aaagtttgga 3515221 aaggaacgtg ttcattctgc tgatgtccga atcggcggac gtttaccgca ttctcctgct 3515281 cctcatgatc tccaagcacc agcacgtacg gaattttttg cacctgcgat tctctgattt 3515341 tatagccgag cttctcattg cgctcatcaa tgccggctct tatccccgcc tgcttcagct 3515401 ccgcctgcac ttttctgcaa tagtctaagt gaacgtgcga aaccggtatg atttgaacct 3515461 ggatcggtgc gagccagact ggaaaagccc caccgtaatg ctcgatcaaa atgccgaaga 3515521 aacggtcgat tgagccgaaa accgctctgt ggatgacaac gggacgaacc ttctcattga 3515581 gttcgttgat atatgttaaa tcaaattttt ccggcatttg aaaatcaagc tgaattgtcg 3515641 cgcattggtg gctccgtttc agggcatctt ttatatggaa atcaattttc ggcccgtaaa 3515701 acgccccatc gccttcattg atctcataag agaggccaag ctcctcaagg acgcgtgcta 3515761 aggcacgttc cgacgcttcc caaaggctgt catcgcctaa tgaatcctcc gggcgagtcg 3515821 aaagctcaac agaatactcg aaaccaaatg tccgatatac ctcatcaatc agccgaatcg 3515881 cttctttgat ctcactctca atctgatcct cccgaacgaa aatatgggcg tcatcctgac 3515941 agaacgtccg aacgcgaagc attccgttta aagcgccgct gtattcatgg cggtgcacct 3516001 gtccgaattc cgccatgcga atcggcagat cccgataaga atacaggctg tttttaaaga 3516061 tgagcatgtg gccggggcaa ttcatcggct tcattgcgaa tcttgtatca tccacttctg 3516121 aaaagtacat attgtcgcga taatggtccc aatggcctga ctgctcccat aaccgctgat 3516181 tcatcataaa cggcgtacgc acctcatcgt agccggcatt tgtttgcagc tcacgcgaga 3516241 agcgctccag ctcattgcgg acaatctgcc ctttcggcaa ataaaacggc atccccggcg 3516301 cttcttcaga aaacataaac agccctaact gtttgccgag cttgcgatgg tctcgttttg 3516361 ccgcttcttc tagcatatgc aggtgcgcat ccaaatcttt tttcttttga aacgcaaccc 3516421 cgtacacccg ctgcaggact tcatttttgc tgtctccgcg ccaataagcg cctgatactc 3516481 ttgtcagttt gaacgccttg atcatccctg tagaaggaag atgcggccct cggcacaggt 3516541 caacgaattc cccttgctgg tacagtgtga tatcctcccc gcgcggaata tcctttaaaa 3516601 tctcaagctt gagccgctcg tctttttgtg caaacagctc ttcagcttct tcgtaagaaa 3516661 cctctatacg tttgatttca aggttctcat ttattatgtt tttcatttct ttttcgatgg 3516721 cctctaagtc tcctgatgcc aagcttttcc ccagcttcat gtcatagtag aagccgtcta 3516781 aaatcacagg ccctaccccc aatgacactt cgccgtacag ccgttttact gcttgggcca 3516841 gcacgtgcgc tgttgtgtgg cgaagcacct gcaagccttc ttgtgaatcg agtgtgacaa 3516901 tcgaaagctc agcatcctcc tccagcttga aactgagatc aacaagcttg ccgttgacct 3516961 gacctgcggc cgccttcttt tgcagactgg aactgatcga accagccgct tctttgattg 3517021 tgatgccttt cggatattcc tggatctgtc cgtccggaag ctgaatgtgt acatgtttgc 3517081 tcattttaga acactcctta ttcattgttg tatataaaaa aacacacccg tcccgcagat 3517141 agggacgagt gtgtgattaa cccgtggttc cacccaagtt cccgacaaat actatgttgt 3517201 cggctcggtg ctgtaacgca gcatagacgg cattggttac ttcagttccc caatgctgct 3517261 ccaaggcggt aaatgatatt cctaagctgg gaagctctca cctttccttc cctctctgaa 3517321 aaccgtaact atcattcatg tccttttcat cgcatgtatt caattcataa aaaaacacac 3517381 ccgtcccaca gatagggacg agtgtgtgat taacccgtgg ttccacccaa gttcccgaca 3517441 aatactatgt tgtcggctcg gtgctgtaac gcagcataga cggcattggt tacttcagtt 3517501 ccccaatgct gctccaaggc ggtaaatgat attcctaagc tgggaagctc tcacctttcc 3517561 ttccctctct gaaaaccgta actatcattc atgtcctttt cttcgcatgt attcaattca 3517621 aataaaaaaa cacacccatc cctctaaaag ggacgaatgt gttgatcatc cgtggttcca 3517681 cccaaattcc cgatcaatta cacatgatga tcggcttaaa gatgctgtaa cgcagcatga 3517741 cggtatcaga tacttgtttt ccctgatacg gctcaaaggc ggtaagctgc tttccctgcg 3517801 ttaggaagat ctcagctgtc cttccctctc tggaaaccgt aaaaagcatc tcgtgtcctt 3517861 atcagtgcct gttgtttcaa taatttttta tatcttacta tatattccca caaagcgcaa 3517921 tcagtgattt acattttttc tgacgcggca gtcccgttat gggcagccag aaacagccat 3517981 acaagcaatg cagcgaggct gtatgccgct cccatcatca aaaacgcaaa cccggcacca 3518041 gcataccaag tggcggacag atgaatgatc accccggtta tcgctacgcc gaccaaggct 3518101 ccgatttgcc ggtttgcatt taacgccgca ccggcgatat tcgtatgtct ttgcccggca 3518161 gcctgcatga tcacagttgt catggcagga actgtaatac cggtacagag gttcataaca 3518221 gacatcaaca ccgccagctg ccaataagga aaatccggag aaatcagcac aaacaacagc 3518281 aatgcaatga tacagctgac cgccattgat acaaacataa gctgaccggc ttcaaaccga 3518341 ttcgccagac gggcaaacag cagattgccg atcacgaaga ccgccatcat cggcagcagc 3518401 tccactccag ccataaagga acttgcccct cctgcttcct gcaaaaaaag gctgagcata 3518461 aacatgccgc caaaaagggc gaaattcagc aaaaacccga taaattgggc agctgagaag 3518521 cggccgtttt tgtataagga cgccggcagg atgggtgttt ttgcagaaat ttcccgcagc 3518581 aaaaacagca caaatgccaa aaccgctgca gtaaatgcta caagaatcac tggcgagcgc 3518641 cagcccgctg aaggcccctg tatcaaagca taggaaagaa acccgagagc catcatgcca 3518701 agcagatgcc cgatgatgtt cacgcggctg cttttcccag gaacgcggct gaggattcgg 3518761 taagctgaaa tgagcgcagc agcccctatt ggcacattga tcagaaaaat actctgccag 3518821 cccgccaact gtaccagcac gcccccgata aaaggcccaa gggctgaagc ggcggaaaca 3518881 agcgcggccc acagtccaaa cattctcgcc cgcgcccgct catcaaggta agaggcagcc 3518941 aaaaggctga gtgagcttgg cataaacaaa gctgccccaa ttccctgtat gagacgtccg 3519001 gcaatcagca tctgcccatt tatagatgca gcgcatagac aggaggccat aacaaaaacg 3519061 gctagaccca agatatagat cgtcttcgag ccgaaacggt cagccaaggc tccgcccgcc 3519121 agcagaagcg acgcaaaagt aagaatgtac ccgtccacaa cccacgttac acctgaaagt 3519181 gacattgaaa gagtgttttt catatcagcc atcgccacat tcacaacggt cacatcaaga 3519241 gttgccatga ggaaaccaag tgcgagcacg atcagcacgg atatgcctgt tgatgatgtt 3519301 gattcttgta tagacccgct atttttcatt acaattgccc tttcacttgc ttgattaccc 3519361 aatcatctat tttttcaaga tcatacaatt ccccgactct gtccataaca tgctgcaagg 3519421 attcttctct cataagattg gaccatttat cctcgatttc cgccatgact gtctccagca 3519481 cacagtgact ttcaccctca aatacagatt gcagcaagcc tttcccctga tacatcgaac 3519541 ctctgccttc gaccgcttga taaacatcat aaagcgtaat gtcagccaaa ggcttcgtca 3519601 gggtaaaacc gcccttcgtc cctggtaagg attctgccaa accggcttga accaatgttc 3519661 tcatcagctt cttcaagtaa gacggagaca cgcgcaatcg ctggcttata gcctctgacg 3519721 tcaaagaagc ctgtaccggc agccgtgaca gtaacagcag cacagaaacc gcctgctcca 3519781 ttcctgattt cattttcatc ctattcactc ctgattcatt atggataact attatccata 3519841 atgaatctct tagcagcttt tgtcaataaa aaaagcaaaa gaaacggatc atttcttttg 3519901 cttggtatgg ttaacaaatc tgcttcagtt cctctatgta ttgaagcgct tcgtcatatt 3519961 cttcatttgt atatttttgc ttgcttttga tggtaaagac tttttctttc ttttcctcat 3520021 cctcaagccc gtcaaagtaa aggatcgtgg aaaccagctc taaaaaccgt gatgaacggc 3520081 tgtttacact gtcgatatag cctttcatat ccggcatgtc cagatcagca tggtctaaaa 3520141 atgcggagcc tgtctcagtc agcgaatacc ggtattgaaa gtagccgccc tttttttcct 3520201 tcacctcatg cagaaatcca aggttgcaca gctcttcaat ctggagcgtc agttcctctg 3520261 aatatggtcc gtaaaagtga aaatcatatt tctcatagaa aggaaactgc attttcttgg 3520321 cgatataaat cattttctgc agcttctttc gcccgatgat ttctccagaa tccgagaaca 3520381 ccttcatcag ttttgcatgt tctttcaaca aattcccgac atctcctttt tccttctttc 3520441 caatttctat gtcagtccca gcagctgccg gattttcatt ttcgcttccg gatgtttagt 3520501 gccgtcacaa atcaagtcct ttggatagta cagcttgtgg tccgtccgcc gtttacctga 3520561 gatggattcc acaatagccg actgtctgga cagctcttta atttggccgt tttgcgtcaa 3520621 gagatggatc ggcagacgct cctcttcctc tcctggtcgg taaaaatcgt atggcagatc 3520681 tgatgaagaa tcaacgacca aataatagct cggatcgatc cccgcctctt tgaacaatga 3520741 agtcagctca aaataagccg acatttcttc attcggattg aattcaacgt attggaaaag 3520801 ctggcggtta atgaatctgc ggcacaagtc ggataaaatc gcgtcttctt catcctccca 3520861 ggcctggaag taatacaaaa taatagattc atccagcttt acataatcct ccagtgtcaa 3520921 ttttccttca aaaatagaat agaaatgaac cggagcgtga gtgaagacat agccttcatc 3520981 gtgcagctgc ttcgccctgt gaagaatctt cgttaaaatg acctctgcac ttctagtcac 3521041 aggatggaag tagacctgcc agtacatttg gtaacggctc atgatatagt cttcgacagc 3521101 gtgcattccg ctttctttaa tgacgatctg atcctcgcgc ggccgcatca cccgaagaat 3521161 ccgctccata tcaaaatggc cgtagctgac gcccgtataa tatgcgtcgc gctggaggta 3521221 atccatgcgg tctgcgtcaa tctgactcga aatcaggctg accacttgct tgtttttata 3521281 tgttttggca atgacttcag caacatcctg agggaaaccc gggctcacct ttctgagcac 3521341 ctgattaacc tccgtgtctc ccaaaatgat acctcttgta aaatcctcgt ggtcaaggtg 3521401 aaagaccttt tcaaatgaat gcgagaacgg cccgtgcccg aggtcatgaa gcagcgccgc 3521461 ggccaaacag agttcgcgct cactgtcatc ccattcaggg cggcctttaa agacgtcatc 3521521 aaccattctt ctgacaattt catagacacc gagagaatgg ttgaaccggc tgtgctcagc 3521581 cccatggaac gtcaaatagg tcgttccgag ctgcttaatt ctgcggagac gctgaaattc 3521641 acgggttccg atcaaatccc atatcagctt gtcccgaaca tgaacatagc ggtgcaccgg 3521701 atctttaaac actttttctt ctgataattt tccatttgga tacgccatcg tcattccctc 3521761 ttttttttag ccgtgtttct attatatcga ctctattctt tgaaaacatc cttgaatttg 3521821 cccggcgatt tgttccatct tcatgaaaaa cacatcttgt gaagcaaaaa agcctgacct 3521881 gagggccgag gctaagaaaa aatatgtttt tactttttta ttttcttttt tactttgtca 3521941 atcagctcat cctctgtcgg agctgacagc gggcgattgt tcacaaaagc aaatgatttt 3522001 ttccgtccgg gcccgcaata agattggcat cctacctcaa cctttgcgtc cgggtccact 3522061 tctttcaaac gcggcagcaa tgttttgata ttagtggctt ggcaatcatc acacactcga 3522121 aattcattag ccatgacgta cgcttccctt catttctatg ttcatctatg tgaataacct 3522181 aaaatcacgt ttcaaaaaaa atcacatcac acttcatttt acaaggattc gactgttcct 3522241 gcaagccgct ccatccttcg tatctcctat tctttcagcc aatttgtata aatattttcc 3522301 aacctggaca ttctaatacc atgaaaagaa aaatgggagt tgagataaat gacaaaacag 3522361 cgacaagacg cttggtcaga ggaaaacgat ctgcttttag ccgaaacagt gcttcggcat 3522421 gtgagggagg gcagcactca gctgaacgcc tttgaagaag tcggcgataa attaaaccgg 3522481 acatccgcag cctgcggatt cagatggaac gcagtggtcc gccatcaata tgaaaaagcg 3522541 cttcagcttg cgaagaaaca acgaaaacag cggatgagag cgctcggaaa cgggcagccc 3522601 gcgaaaaaaa gattattata tcagcctcct gccgttgatc ctgaaatcat tcaagaaacc 3522661 gctgcagaag agccggttaa aacggaaaca ccatctgtcg aaaatgagca acctttaatg 3522721 tctggcgaac acatgccttt tgttgatgaa agctttaagg aagagttagc tagtctatca 3522781 cacttattgt ctcctcaaac gcctgcagct gcgcctgaga tgacgatgaa tgatgtgatc 3522841 cgcttcctgc agaattacga aggcaatcac gagcaatcat cagcattaaa aatggaaaac 3522901 gagcgtttaa agaaagaaaa tcaggaattg caaaacaaaa cagagcagct agaggcagaa 3522961 gttcaaaagc ttgaaaaaga ccaaaaaacg atccaagaag attatgaaac cttggtgaaa 3523021 attatgaaca gagccagaaa gctagtttta tttgaagaag atgaacatgc ctctccgtcc 3523081 ttcaaaatgg accggaacgg caatttagaa aaattagcgg aatgacatag aaaaatccca 3523141 aaacgggcag ctgttttggg attttcgcca tgtgcaaaat ccccttttct attgagaaaa 3523201 gagaatttcc tcattttgca gccggatcag ctattcttgt aaaatgaggc caagcttatg 3523261 tgaatctatt aagacatgtg agctgcctcg gccgtttttt gtttccgagg cgcagcagaa 3523321 atgaccaaaa gccccagcat cataagcgca atgcccagcc acgaggaagg cgaaagcatt 3523381 tcccctatga aaaacacgcc aagcaatgaa gccgtcagcg gttcagctaa agacagcgtg 3523441 accgccgccg aggccggaac cccggtaagc cctttcgcaa acaaaaagta tgcggcacat 3523501 gttgcaatta acccgatgta aaggcttgtt cccagtcctc taggggtcaa tatccacgag 3523561 atatctaact gccataatag cggcgtcagc aagatggcgc tgatcatgaa tacaacggcg 3523621 gaggtcgctc gcggaggctg ggttttcatc atcgctttac tgatgagcgt atagcctgca 3523681 aaagaagcac ccgctccaag cgccataaga acaccagcca catcaatccg aacattggaa 3523741 ctgtcggaaa acagaagcca gcaacccgct aaagccagca cagtcgcaat ccaccaggag 3523801 tttcgcgggc gtttcttcaa tacagcccat tcgagggtcc cggcaatgat aggcgcactg 3523861 ccgatggcaa tcacagttcc cactgcaatt cccgtttctt taaccgctgt gaaaaacagc 3523921 ggctggtaac acgccataca aacagcggct aaaaatacga gcggccatgc ccaatttttc 3523981 acgtgaagct cccggctgat ccaaaccgca agcagcatgg cgcttcctcc tattaataac 3524041 ctgaacgctc caaatgccag cggtgtggcg ctttctggag ccaatgcctg aacggttccc 3524101 gtggtccccc agaaaaaagc cgcaatcaat acaaaaaggc tgtaaatatt ccccttcatc 3524161 tgcctctccc ctttaatatg gatgctgatg tcattttatc gtttttcttt ttgtcgtggt 3524221 tatctgtatg taagaaggac ttatctgaaa ataagattat tgaggtaaaa tgccgcttga 3524281 gataaaaaat gcatgccggc atatacagcc ggcatgcgaa gaacgttcac ccaaatacct 3524341 ttgcattccg ctcagccatc cggacgaggt ttttctcaaa ttccatttcc tcatcaatgg 3524401 acagtccagc tgaataaaga tgggtgctta acgcttttaa ttccgtcaat aaagcgaaca 3524461 ttaagtcttg tacggagatg tctttttgaa gaagctcact taaggacgcc atcgtttccg 3524521 gacgtatttc cggatagacg ccttttttat cgttttgttt gtctttcagc gccgcttgat 3524581 agaatcgtct gatcaagtcg gccctttcac tgccgctttt atctgcacag agataaattt 3524641 gaacagcgac tccgccgcga acgcgtctct gagagatgcc ggcgaacttt ttgccattta 3524701 tactgaggtc atagctgccg ggacaataag acccttcaat ttcataggct tcgatctttg 3524761 cgttgtacgg tctcagcatt cgtctcatca gctcgaccat cgcttcatat cctttgtcta 3524821 tatcgatgcc tttcttttcg tcctcgaata tgagagagat atttaaaaca ccgtcatcca 3524881 atacgacggc aagaccgccg gaattgcgta cgatcacacg gtatccttcg ctctccagca 3524941 aggagatacc atcctgcaaa aacgggaggc gtgtatcctg tattccaagg acaattgtat 3525001 cgtggtgcac ccatgagcgc gctgtcgccg gcgacacgcc ttttccgacg gacatgcata 3525061 gcgtatcatc cattgcgaag gattgcttcg catcaaataa agggccgaga ctggattggt 3525121 caatgactct ccatttcggc tgcatcagta aatcaatcgg ttggtttgcc atctatgtaa 3525181 aaccctttca tgttaggctt attgaacgaa aactattata tcatttcagc agctgtgatt 3525241 gataattgct tttcagcatc gtaataaaaa tttctttatt ttttgtattc tccatgagag 3525301 gagaatgaat gtaagacagc ttgcgcttta acgagaaatt attaatatgc agaattgaaa 3525361 tttcgcggtg gatcaaatcc ttacgcagca cgcttctgga tagaaccgaa agtcccatgc 3525421 cgttaatcac cgcttccttt acaccttgat tgctgctgat ggtaaacatt gatttcggcc 3525481 gaagtccatt tgaactgagt acatgatcga gatattctct cgtcccggag cctttctctc 3525541 ttgtcaccca cgcttcgttc tgcaaatcgc tgatcgaaat ctctttccgc ccggcgagcg 3525601 gatgctgatt tggagcggca atgcacattt catcctccat gaacggttca atttccagct 3525661 cattctcgtt tgtatgtcct tcaatcagcc cgatatcagc ctgaagcatc cgcacacgct 3525721 cgctgacctc ctctgtattg ccaatcatga catctagatt cagctctgga tacagctttt 3525781 gcagctgggc caatagcggc ggaagaatat actcaccgat tgtaaagctt gcagctattt 3525841 tcaattcacc cttcacatag tgatgatgcg catagatttc agccttggct tgttcgtaga 3525901 gaaacaccat ttgctttgct ctttgatata aaatgtctcc tgtcggcgtt gtcgtaaagt 3525961 gttttggcga cctgttcaga agagccgttt gaaattcttt ctcaagattt ttgatatgca 3526021 gactgacgct gggctgggag atcatcagct tttccgccgc ttttgtgaag tttttttctt 3526081 ctaccaccgc tataaacgtt ttcagcacgt cgtaatacaa aaaccccacc cctgtcatta 3526141 atgaaatata tggttatgat tagttttctt tattgtactc atatcatccg tcttggtaaa 3526201 gaagggctat acagaagcgc aaaaaaggca gccctcggtc gagagctgcc attgtcttca 3526261 attttattac agtgcttgcg ccgctgtaat taatgcgaga ttgtaaacat cttcagcgtt 3526321 acatcctctt gaaaggtcgt ttacaggcat atttaaacct tgcaggattg gtcctaccgc 3526381 ttcaaagttg cccaaacgct gagcgatttt atagccgatg tttcctgctt caagacttgg 3526441 gaatacgaat acgttagcgt cccctttgat ctcggaatcc ggcgcttttt tctcagctac 3526501 agatggaaca aatgcagcat caaattggaa ttcgccgtca agtgtcagtt caggcgcttt 3526561 ttctttcgcg attttcactg catccgctac tttttctgtt tcatcagatt ttgctgagcc 3526621 ttttgtagag aagctgagca ttgccacgcg aggctcaatg tcgaacattt ttgccgtatt 3526681 ggcactttcg atcgcaatct cggcaagatc ttggctgtca ggtgcaatgt tgatcgcgca 3526741 atctgcgaat acgtattgct cttctccgcg agccatgatg aacacgcctg aagtcttttt 3526801 cacgccttct tttgttttga tgatttgaag agccgggcgg acagtgtcag cagttgagtg 3526861 agcagctccg cttacaagtc cgtctgcaag tcctttatac accagcattg taccgaagta 3526921 gttctcgtct aataatgctt tacgagcctg ttcttcagtc gctttgcctt tgcggcgttc 3526981 tacgaatgct tgtacaaggt cttccatgcc ttcatatgta tgaggatcat aaatcttaac 3527041 gccgcccagc gtaaggttca attcttttgc ttttgcttgg atctcatttt cattgccgat 3527101 cacaatcgga ttcagcactt tgtttcctgc aagcttgctg accgcttcta aaatacgctc 3527161 gtctaagcct tcaggaaata caattttaac gtcttttcca gctacttttt cttgcactgt 3527221 tgaaaataaa tctgccacaa taaaacctcc tcaaaaagtt acaaaaacgc tttcttttac 3527281 tagcatactc ttcttccaat caaattcaaa cagccaactt tcattatagc gctttcataa 3527341 aaaaatctta tttttctaac taatttaagt gactcaatct tcccttatag gttcttctat 3527401 tttgatggag ttatacggaa gggatgttca aggtttctcc acagtagaat cggataaact 3527461 atggtatagt gaaggcaatc atgaaaagat aatgggagtg aagataaatg agtgaacagc 3527521 aaatgacgaa tgaagcggca aaaacgcttg acggctggta tgcgcttcat gatttccgca 3527581 caatggattg ggcttcctgg aagcttctgt ccagtgatga gcgccaatct atcatacatg 3527641 aattcaccgg gttgcttgaa aaatggggcg tagcccaaaa agaaggaaaa ggatcgcaaa 3527701 ctctttacag catcgtcggc caaaaagctg attttatgct gatgatcctt cgtcctacaa 3527761 tggaagaatt aaatcaaatt gagcttgaat tcaacaaatc aagacttgct gagttcacca 3527821 ttccggcata ctcctacgta tcagtggtag agctgagcaa ctacttggca agcggtgacg 3527881 gcgatcctta tgaaaatccg catgtgcgcg ctcgccttta ccctgaactg ccggaatcta 3527941 aatatgtatg cttctatcca atggataaaa gaagatctgg caacgacaac tggtatatgc 3528001 tttcaatgga agaacgcaga aacttgatga gaagccacgg tttaatcggc cgcagctatg 3528061 cgggcaaagt caaacagatc atcaccggct ctgtcggctt tgacgattac gagtggggcg 3528121 ttacattatt tagcgatgat gtccttcaat tcaagaagct agtgtacgaa atgcgttttg 3528181 acgaagtcag cgctcgctat ggcgaatttg gttcattctt tgtcggcaat cacctttcgc 3528241 ttgatacact tcctcaattc ttatatgtat aatatcccct cccgccctat ccggcgggag 3528301 tttttcaatt ctcctttatc agaatttaaa taaaatttgc tattttcttc gttttttctt 3528361 acgatgtaga taataatcca tttttttcaa aggggtgcag ttatttgtca aaacgaaccg 3528421 catttgttat gggagccagt caagggatcg ggaaagcaat cgctctgaaa ttagcagacc 3528481 agcacttttc cctcgtcatt aattcgcgaa atttggataa tattgaatct gtcaaagaag 3528541 acattttggc caagcatcct gaggcgagcg tcattgtcct tgcgggcgat atgtctgacc 3528601 agcatacgag agcgggcatt tttcagaaaa tcgaatctca atgcggacgg cttgatgttc 3528661 tgattaataa tatcccgggc ggcgcgcctg acacatttga taactgcaat atagaggata 3528721 tgacggccac gttcactcaa aagaccgttg cctatattga cgcaatcaag cgtgcttcct 3528781 cactgatgaa acaaaacgag tttggcagaa tcatcaacat tgtcggaaat ctgtggaaag 3528841 aacccggcgc caacatgttc acaaacagta tgatgaatgc cgctttaatt aacgccagta 3528901 aaaatatttc catccagctt gctcctcaca acattactgt caactgtctg aatcctggtt 3528961 ttatcgctac agaccgttat catcaatttg tggaaaatgt gatgaaaaag aacagcatat 3529021 ccaaacagaa agcagaagaa cagattgctt ccgggattcc gatgaaacgg gtcggatcag 3529081 ccgaagaaac cgcagcgctc gccgcatttc ttgcctctga ggaagcctcc tacatcacgg 3529141 gacagcaaat ttccgctgac ggcggcagca tgaaaagcat ataaaaacat cccgcttttt 3529201 agcgggatgt ttcttgtaat gacccgaacg gcaggttcag cttttgaatc cgcgtgacaa 3529261 attcccgcag atcctcctgc ttcgacacca ttgagattct gacatgcctt tttccgttgc 3529321 ttccaaaaat ttcgcccggt gtgactacga catgggcatg ctccagcaag taatcggaaa 3529381 attggtgaga tgtctcaaac gtattcggaa tttcagccca tacgtaaaag gttccttttg 3529441 gcttttccat cttccagccc agttcctttt cacaaagcgc cgtaaaaaag tcaattcgtt 3529501 ccttataaat tcgtttcaac gattccgtat gctccggatc tccagaaagc gccgcactcg 3529561 ctgcctgctg cagcccgccg aacatgccga caaatacatg atcctgaaat tcattgacgg 3529621 cctgaatgat tttttcgttc ccaaccgcaa acgccattct ccagccggcc atgttaaatg 3529681 tttttgaaaa tgaataaagc tctgctccga cagttttggc atcctctgcc tcaagaaagc 3529741 tggccggttt ttgatcgaat tcaaacgccc cgtatgcaaa atcatgaatc aaatggatgt 3529801 tatgctcttt cgcaaaagca gcagcttttg cataaaaagc cgcatcagcc acagctccag 3529861 tggggttgtt cggatagttt aaaaacataa gcttcgcttt ttccagcacg gctggatcaa 3529921 tcttttcaaa atccggcaga tagccatttt cttcatacag cggcatttcg taaagctcag 3529981 ctcgcgccat cgtaatccct gataaatatt caggatagcc tggattcggg actaaagcga 3530041 tgtctcccgg attgagcagg cattgtgtca gcacatacaa tccggctttc ccgcctccga 3530101 aaagcgcgac ttccgtttca ggattgattg tcactccgta ttccctttta tagaaagcgg 3530161 cgatcgcttc ctttaaaaaa ggatagcccc tgaaagggcc gtatccatga aacgaaggat 3530221 tcagagaagc ctcccgcaaa gcctcgacaa tatgcggcgg agtgggaagg tcagggttcc 3530281 cctgtccgag attaatgata tgggctcccg ttttttccat ttcctttacc ttttgaaaaa 3530341 cgagagaaaa ctcctgcctt ggaagtgtct tgatgacatc ggacggtgtt atttccatct 3530401 aaaagactcc tttttgctcc gttttgttat cccgttccaa aaacgatttg ttgacgagct 3530461 tcgtatgcaa aaacaaaccg catacgatca cgacaatcag ccccataatg accggagcgc 3530521 ttaggatgtt aatgaacatt gaaccaatag aaatgcataa tccgatagac gcttcggcca 3530581 ctgaaaaaat gcgcccttga atctggtttg ccgcattttc ctgaaccttc acttttgcaa 3530641 gcacttcccc gtattccatc gcgatgaaaa agaggatcgc cgcgatgaca gaaacagcga 3530701 atatcggtgt gaataaaaac agcgccagcg agacaatgga taaaacggta aagtacgtca 3530761 ggcctctatt gttgttaaag ccccatttgc tgacaagcgc cgctccgata aagccgccga 3530821 agccgatgca gaacgtgaga ataaagttgc cgatttcccc gtcacccaga aagcggctga 3530881 caatcggaaa atagctgtac acaactcccc acagcaaagc cattgtaatc atcgtaaaca 3530941 tggcgtttaa tacgaatgaa ttggttttga tttccttgag tccttcctta aaagactgaa 3531001 aggcctcttt aatgttttca gattgaatcg gcacaaattg cagcttgatg cggctgataa 3531061 aaaatgccga aaccaagtat gtcacaccgt taaaggcaac agccagctct acagatccgc 3531121 ctaacagaaa gagccctccg gcagccgccc cgacgataat ggagatggtt gtcgcttttg 3531181 caaataacgt gttgatgctt ttaatatctg attccaagga cgacatgaca gcgagacggg 3531241 cgggattaaa aaacacgccg cttccataag taataaacag cagggccaga aaaatcagcg 3531301 gatactcgcc ttttggaaga aatgtgagcc ccaaaaagat gatgcctctg atgatatccg 3531361 tccacagcat gatcttaatt ctgtctaacc ggtcgaccag aacacccaaa aacggctgaa 3531421 acaccatcgg aatgcttctg accacgatga ccccggacgt cacccaataa tcgtgataat 3531481 atgtagacaa aatgagcagg gcagggagaa cacaatagtc tcccatgaac gatagcgcct 3531541 gcccgtaaag caagtattta gagttgggtt tcagctgttt catactggca gcacatactt 3531601 tgccgtcagc ttcgcatgct gctgaatttg tctgattgat tcagccacat cctgtgaatt 3531661 actgcctttc agttcaaatg cagcaatgga attgaaagct tcaaacaatg tcaaatcaac 3531721 tgaagtgcct ggtgctgcgg ccgaaaaaga aacgatttca gtatcccctt ttaaaagccc 3531781 gtccggaata tcgatcgctt caatgaccaa atcctcagca gtttcaggaa tttggccatt 3531841 ttgtttgaaa tgctgcgggt acaaatggca gtcggcaaca taataaggct cttgatccaa 3531901 taatccgtcc ggcagatcgg cgtcttttcc gaaacagagg acatctaata ataattgcgc 3531961 catatcaagg ccaaagacct ttttaatatt ggggatcata ttccagccgg caaatctggc 3532021 tgccgactct attaaacccg gttctctgtt tttcattagc ttgatctctg tatgtgttgc 3532081 gcaattttgc agtccaagcc cttcatttgc ctttttggca gcttcgacaa ttttcttttt 3532141 tgcctcttca tccagaatgg acggcgtaat gtgggatgtc tctgtaaacc cgatttgcgg 3532201 cgttttatca tgaatggcga tcgggaaata ctcaccgtca gccatgatgc cttctatact 3532261 gatatagtcg gagtaccctt ctgtttgata ccagtctccg tactcaccct gtaaaaattc 3532321 ttcagcgata aacggcgctt caaacgtaac cgcctttggc acgttaattg atttcagata 3532381 gtcattgact ctgttaaatt catcttctgc cgtctcagtg tccgtaatca gcgttacacc 3532441 gatagaactc gctaagtatg taggctttaa gataagaggt gtgccgatct cttcaagagc 3532501 agcacggaaa tcttcaagag ttgtgactcg tttgtttttg atcgatttga ctccggcctt 3532561 attaaaagcg tccctcattt tatttttatc tctggcattt tcggctgcct gcacgccggc 3532621 acctctcaag cccagacgtt cacaggcttt cgccatcgga gcaatgaata attcattgtt 3532681 tgttgtgatg gcatccgccc caaacatttc ggcaaccttg acgatttgct cgacgacctc 3532741 ttcctcaggc ttgttatgat cttcatgcgc ccaataaatg gaatcagggt gttcaaaatc 3532801 agctaaactc ttaaaatagt ctttatcttt tatgaccgcg accgagtatt tttcaatcaa 3532861 tgctgcatgg gaggctgtaa ttgcaaaagg tcttggaata aagctgacca ggttatattt 3532921 ttcagcagcg cttttataaa acatgtgcgg cgggcagcct ccaagatcag cgatgaccaa 3532981 tactgttttt ctctccatat gtaaaacact ccttctctat tgtgcggtgt atcctccgtc 3533041 tgcggtgatg gcgcttccgg tcatatagct tgataaatcc gaggctaaaa acagcatcac 3533101 atttgcgatt tcttcaggtt tcccaagcct cagcagcgga tttaccttcg ctttttcttt 3533161 tttaatctct tcaagtgtgc cttcattatt ttcaaggaat gatttttcat tcagcggtgt 3533221 gtcgatgatc cccgggcata cgcagttcac ccgaatttga tgtttcgcat aatcaacggc 3533281 cattgattta gtcagctgca aaaccccgcc tttgctggcg ttataagcag gaatatcagg 3533341 ccatgccacg agtccgccga cagagcacgt attaatgatg ttgcccttgc cggcggccag 3533401 catatgcttg agtgcatgtt tgctcattaa aaacatgccg gtcaaattga cttgcagcac 3533461 cttgttccaa tcgctgagct ccatctcgtg aataggcgcc acgatttcga tgcctgcatt 3533521 attaatcaag acatcgagcc cgccaaatgt atgaaccgcc gattcaactg cgtgctggca 3533581 ggcagcttcg tctgtgatgt ccgtttgcac aaagtgcagc ctgtcattat tttcttttcg 3533641 taccattgct tctccttgcg cttcatcaat atccgccaca accacattgg cctgctggcc 3533701 caaaaaagcc tgaaccgcag cataaccaat gcctgatgcg cctcctgtga tgaggacggt 3533761 tttatcggtg aggttcatga tcattcatcc gccttcattt tttttgcttt tgccctgtta 3533821 tagcgcggcg ggaagaagat attaatcgat tttgattctt tttctgaacg gttgatggca 3533881 ccatgatctt cgcgaggctc acagaaatag gctgtgccga atttcatctc gactgtgcag 3533941 ccttcgaccg tcatgtcata gccgccgccg atgcagatgc ctatttgttc attccgatgt 3534001 ttatggaaag gcatttctcc gccatttcca gggattttgg caagcataat ttctacccaa 3534061 tcctcaacaa agaacgtgac ttccatgccc ggcagcaggt ctcttgtttt gaaaatatcc 3534121 aaaaagtagt cctcaggact tgtatatgtt tcatcagctt tcagccgctt gatatcaata 3534181 gcaatcactt cttggtctgt gtcgtttctt gccccgtgag gcacatgcgg cggcgcgata 3534241 taggcagatt ccaaggctgt catttttctt gtcacatctc cgacagtcat catcagctcg 3534301 ccagaaacga ccatgccgat ttggacctcc ttatgctgat ggggttcaac attggtatgc 3534361 ggcgggacgt aagacattaa tacttcagta tcccctcgta cggttgaata ctgcctcact 3534421 ccgttttccc attcaattaa tttcggtgtc gggaaataaa gctcctgcat atcttcttta 3534481 gttttcatca tcaacgtctc cttttccaaa taatgaccag ctcattggaa tgcttttgaa 3534541 tgtttttaca aaggttagcc cgtacttttg ccgtgcaagc tcattggtta aggcaatgtc 3534601 atacaaacct tcttttactt ttcttgcggc ttgactggtt gaattgacta gtttgaaacg 3534661 aacatctttg cgggtaaaat attttattaa attaataggt gaaggatgtg aaacaataac 3534721 agatgtatca agcatatcgt ctctgaattc aaaatcagga cgaacagcca ggccgtacat 3534781 cggtgtatcg cacctgaaga tctgcaatag ctgcaaatcc ggcctcatgt agaaatgctt 3534841 aatgccatcg taagcatgtg ggacgatggt atattccagc gggctttgga gcgtcctttc 3534901 gatgcacgat tcaaaagtat catgcaagga caatttactg ttcagccctt gtagaagagt 3534961 aaaattggaa atgaaatgct ttgctgcgta ctcactgctt gtcccctcag ggccgagcgt 3535021 gttgactgta atgagtttgg atagtgaatc agttcttttt tttgtctgaa tgctattatc 3535081 caatataatc atgagcacca accaatcttt taaaatttta agtaaatttt atccagtgga 3535141 aattgaactg tcaatgtttt ttgaaaatat tgataattat tcccatacaa acaaaaaaac 3535201 cctttaaaaa gggtttttaa ttataggaat ttagaaactt tgtttattga gataaggact 3535261 gatcggcctt ctgctcaagt ttgccgtact ttttatatgc gaatacactg agcacaaatc 3535321 cgaggactgt gatggcggcg caaatcaatc cgacagctgc atagccgtat gccacatata 3535381 cgggtcccat taaagcagaa cctaatgtca cggccagatt cgaggcgaga ctgtaaaaca 3535441 ccatgacttt tcctcgatga cgctctgagc agtcactcaa aatggtgctg agcagcgtca 3535501 ccgtcaaact ttgcattaat ccccaaataa ataggctggc gattaacaga aacatagacg 3535561 ccggcgcata tggtaaacac gccagcagaa cgctgatgac ccccagcgca atcaaaaggg 3535621 agcgcatttt tccgatgcgg tcggctatct ttcctgtaat cacactcatg gaaaacccga 3535681 ttccataaat catgataaat aagcccgcag ccgtgtttcc tccggtaaaa acgtcctgaa 3535741 gataggtgcc taaaaaggaa tacataccgt aaaaaccaat catattacaa aaggttattg 3535801 tgatataaac aggtacacga gggactttca gcgcatcccg gaatgttcct gcgggctctt 3535861 ctatttcttc cttgccgctg tttttatgtt gggcatggcg gcgcatttca aggagaatca 3535921 gcagaacaac taaaacaccc atcagggcga aaatccaaaa cgtccatctc caatgcagga 3535981 cgccgccgat aaatgatccg agcggcactc cgaaaatcag cgccagcgac cagcttgaaa 3536041 cgatcagtcc catcaccttg ccccggtatg tataaggaac acgatcaccg acaactgcgt 3536101 aagcggtcgg aacaaacgct cccgcagcca atcccgaaag cgcccggcct aaaaagaaga 3536161 aaaaaatatt ttgagctaaa gcgcatatca ccgttcctat gataaaaatc ataagcccgg 3536221 ccaataagct cagttctctg gagtatttat cgcctaatgg aaccaaaagc ggcgcaccga 3536281 taaaaatcat aacgccgtaa atactgatag ataacgcaag gacgctgaca tctgagctga 3536341 aggcttttgc taaatccggc agcagcggtg agatcacaag ctcttcagat ccggctgcaa 3536401 atacccccat cgttaaagcc agtgccaaca ataacggaaa atgatgtttt gttttgatgt 3536461 cattgttttg attgctgttc attctttctc aaacacctct tccataatct tcttatcata 3536521 aagttgtatt atagtttagc attgtttttt ctctatttac aattcgaacg aaatatttat 3536581 aagttttatt attttcattt aaatcccatt atatatttct atatttcatt ctaaaaatac 3536641 atgaggatgt aacacgtaaa aaaagctctc cggcctcccg gagagctttt tctattgcgc 3536701 ctctgtctgc tttttttcaa tcgtttcatg atttatacgc tttttgatgc ttagatgata 3536761 gtatgcataa cagaaaataa tgatcggcac accgcagtat aagccaattc tttgatccgg 3536821 aatgaaaata aggctgatca acacgcagcc atataaacaa aatccgagaa tcgggactag 3536881 cggataaagc ggcgttctga actccagatc attcacattt ccgccttctg ccaggaaacg 3536941 cctgcgaaag aaaaattgcg acgcacaaat ggacatccac gcgacaactg tcaccatgcc 3537001 cgagattgag atacaccata aatacactgt ttctgcagcc atgacacttg tcagcagcga 3537061 acagcctgaa atgcctagcg taatcagcag ggcattcatc ggcacgcctt tttttgtcag 3537121 tctggtgaga aaggagggac ccatttgatt tgatgaaagt gaccacatca tacgcgacgc 3537181 cgcatacaat cccgaattag caacagataa aatggccgtt aagatgacaa agttcatgat 3537241 atctgccgaa aatgggatgc cgatttgatc gagtactgct acaaacgggc tttcaatcac 3537301 ccccgccgtt ttgtacggaa ggatggcaac caagacgaac atagcgagca caaagaaaaa 3537361 cagcgtgcgc caaataacat ttcgaatgga ctttggcagt gttttttccg ggctttcact 3537421 ttcccctgcc gcaatgccga caagctccgt tccctggaac gagaagttta ccatgaccag 3537481 cgtaaacata acggccagca ccccattagg gaaaagccct ctatcagtca taaagttaga 3537541 caaaaagggt gtctcctgtc cgcctttaaa gtcaatcaag ccaaacacag cggctccgcc 3537601 aatcacaata aataatatga tcgccgccac tttgatgctt gaaaaccaaa attccatttc 3537661 cgcaaagctt ctgacagaga gcgcattaat caaaaagatg acgatgccga acacgaggca 3537721 ccatatccag atcggaacgg agggcagcca cctttgcatc aaaatgcctg ctgacgtcag 3537781 ctctaaccct actgtattgg cccagctgaa ccaatacagc cagccaatca taaagcctgt 3537841 cgactgtccc agaaatttag tggcgtaggc ctgaaacgat ccggccaccg gcatggcaac 3537901 agccaattct cctaaacaaa gcatgacgag atacattaaa aatccgccga tgatatacgc 3537961 ggcaatggcg ccgagcggtc ccgcctggct aatggtaaag ccagagccta gaaacagccc 3538021 agtgccaatc acccctccca aagcaatcat aaacaaatgc ctgcttttca tgctgcgctg 3538081 caattcattt ttatgattct gcatcatcct tccccctttg gttcttttgc cgtgatggtc 3538141 atccggtagc tttgcaaaag atgaacggtg gtttgctgta tgaggagagg caatacatga 3538201 aatgtgtacg gtttatagac tcgttctgtc catttatggc cgtcttttcc gtacacgccc 3538261 atattaatgg atggaatatt cagcttgcgt atgtctttga acggaatggt cccaatcata 3538321 ttccacccag ggaagttcct gataaaagaa tcaatttcgc catcggtttc gtgcagtgat 3538381 aaaaaactgc cgtctgccaa gtaggggaaa aactttttga agacaaatgt ttcgcctgtc 3538441 gattcagcgg ttttgtcagc cgcttcttta atcacatgct gcaaaagctg atctcttgcg 3538501 ctatcttctt tcaaatagtt atgcggcagg taaggaggtg cgtaaaatag aatgactttt 3538561 gcgccttgat cggggtcaag cttttgaagc tcttcgattg cctgaaagca tctcatgcga 3538621 agttcaaggt gctcgttggc tttgaatgtc tgctcgatac actgctcggg atctattccc 3538681 cggtttctca gcttttctaa gtattgctcc aggctataca cttgaatgcc ccatgataaa 3538741 tgtttctttg gcaggttggc tctttttaca tattcttcgt aataatctga taatttttgt 3538801 tctgtctccc ggcatgcttc ctcagtgact tcaataagca aatccatcat ttcttttgct 3538861 gttctttcat aaataaaaca attgaaatac aagctggtgc tgacagccgt ttgcacatta 3538921 taggattcct tgttatcacg ctgatacaaa caggatgggg gcagaaccaa ctccccttca 3538981 accttttctg ccagatggat gttattgtgg agacggcttg tgatttcaga tgaaatgaaa 3539041 tttgggtcaa tccctgccag tgtatcgcca acatggactt cacgcccgta aatgtaaaag 3539101 caaggcaaca gttttcccgc ggctccggta tagatatatc ttgtctgatc accatcgtaa 3539161 agcggggtaa taaaatccgt attaatagca gccaaatagt gaagctgttt ttcttttttt 3539221 agccggttca gctctgaaat gctggcgaga atgcccgaat gctggctctc ctcatcggga 3539281 ttggccataa acaatacatt tcccggcaac gtctcaaggt tctccgaaaa atgcaggaga 3539341 ttggctaaat gcacggcgat gccgctttgc atatcgacag atcctcttcc gaacatccac 3539401 tcgcctgatt tggcatcccg ctgaacatcc tgatcgaact catagcggct gaaatactcg 3539461 gccaatttct cacaatcaaa agcgatatcc tttaaagggc cgaaatcttc aattccaact 3539521 gtatccagat gggcatggta aatgactgta tttcggcttt ctccatgtcc tttaataaac 3539581 gcaaaaatat ttttgcgttt gtatgggtca ttgggaatgg cctgttccca cacatgactg 3539641 gggttttcct gaaaataagg atagctcgtg atcacttctt tgatgaaatc tgcttttgtc 3539701 ccttctccaa cggtgccgtt cacgctgctg aggctgacca gagatgctgt cagcgcctcc 3539761 actctttcag ccggattcat gtgactgatt tttgtatact gcataaattg tcctcctgat 3539821 caaaaagttg aaatcgtgcg atccgctaaa gaatcgcacg attttatttc tctcaaatca 3539881 aaaagcttcg gacgttgttt tggcttgcat atgaagaatt aagtaatcgg gaccgcctgc 3539941 ttttgagtct gttcctgaca tattaaaacc gccgaacggc tgatagccga caattgctcc 3540001 ggtacatcct ctgttaaaat ataggtttcc gacatggaaa tcctcgcgcg cccgttcaat 3540061 gtgcgcacgg tttttcgtca gaagcgcacc tgttaatccg tattccgtgt tattggcaat 3540121 ctccagcata tgatcgaaat cacgcgcttt gcaaatcgca acaaccgggc cgaaaatttc 3540181 ttcctgcatc aagcgggcgt tttcatcaac atctgcaaag atcgtcggct gaataaagta 3540241 gccttttgaa tcatcgcctt ctccgccggc caatagcttg ccttcagatt tgccgatttc 3540301 aatgtatttc atcactttgt tgtaggatgc ttcatgaatc acgggaccca tatacgtatc 3540361 aggatcttct ggattgccga cagtcagcgt tttggtcagc gccacagctt tttccaccac 3540421 ttcatcatac acatcctgat gaatgaccgc gcgggagccc gcagaacact tctgtcctga 3540481 atatccaaat gctgaataca cgatagagga tgcagcaagg tcaagatcag cgtccttgtc 3540541 gacaagcact gtgtcttttc cgcccatttc tgcaattacc cgtttgagcc atttttggcc 3540601 cggctgcact ttggcagctc gctcataaat ccggcagccg actgcacggg aacctgtaaa 3540661 tgagacaaac cgtgtcttcg gatgctcaac taagaaatca ccgatctccg caccatctcc 3540721 cggaatgtaa ttcagaacgc cgtttggcag acccgcttcc tccatgacct cgacaaattt 3540781 tgctgccact accggggctg cgtcagccgg ttttaagaga atcgtatttc ctgtcacaat 3540841 cgctgccacc gctgttcccg ccataatcgc gagcgggaag ttaaatggag aaatgacgat 3540901 gccgacgcca agcgcttcgt aatgatattg attgacctcg ccagcacggc tcttcaccgg 3540961 agccccttcc ttgagcttta acatttggcg cgcgtagaac tctaaaaagt ctatcgcttc 3541021 agccgtgtcc gcatctgctt ccttccacgg ttttcctgct tccttcacaa gatagcttga 3541081 aaattcatgc tttcttctgc gcaaaatagc cgctgcctta aagagaatat ttgcgcggtg 3541141 ctccggtctt tgttttttcc aggaatcaaa tgcctgcaat gcggcttgca tcgctttttc 3541201 agcaagctct tgatccgctg tagacgcgta cccaatgatc tcttctttat ttgccgggtt 3541261 aatagaaatg attttgcggt ccgtttcaat tttttctcca tttatgacaa gcggataatg 3541321 cttgccgagc tgagtgttta caaaggccaa tgactcccca aatgcagttt tattctttgc 3541381 ttccgtaaaa tcggtaaatg gttcgtgcgc gtatgtgact gtcatatgta gtccccctcg 3541441 tgttatgaaa tatatcttcg catatgaata aaaatgcaag aatcatgcca ttttcttgtc 3541501 ttttgctgaa aaaacttgtt gaatcgaaca gaaatttgtc taacaggtga tcacctttct 3541561 ctttttccga tcttgaacgc aaatttattt tgcgtttttt gctctttacg caaaaaacaa 3541621 atgcaaaatt attttgcgga ggcttctcaa attagaccca tccgcggaaa cgcgatgctt 3541681 ctgccgattt tctgatgccc gtcatgtaag ccgccaaacg catatccact ttatgtgttg 3541741 ccgctgtttg ataaattgtt tcgaacgagc tgaccatgac gcttctcagt ttttctgcaa 3541801 cctcttcttc cgaccaataa tatccttggt tgttttgcac ccattcaaaa taagaaaccg 3541861 tgacgccgcc ggcactcgct aggatatccg gcacaagcag cacgcctctt tcattcagga 3541921 tcttagtggc atcaatggtt gtcgggccgt tcgccgcttc aacgacgatt gacgcctgaa 3541981 tgttatgtgc gtttttggct gtgatttgat tggagatcgc ggcaggcact aaaatatcgc 3542041 aatccttttc aagcagctcc tcatttgtga tgacgtcagt aaataaattg gtgaccatac 3542101 caaagctgtc ccgtttatcg agcaaataag ggatatcaag gccgtctggg ttgtagagcc 3542161 cgccattggc atcagaaatc ccgatcacct tcgcgcccgc atcgtgcatg aatttggcca 3542221 ggaagctacc cgcgtttcca aagccctgta tgatgatgcg cgcgttttgc agcttgatcc 3542281 cttttttctt caccgcctct tcaatacaaa tcgtgacgcc ctgtgccgtc gctgtttccc 3542341 gtccttgcga tcctcccaaa acaagcggtt tacctgtaat aaagcccgga gaatcgaatt 3542401 cccgcagccg gctgtactca tccatcatcc acgccataat ctgcgaattg gtgtacacat 3542461 cgggagctgg aatatccttt gtcggaccga cgatctggct gatggcacgg acataccccc 3542521 tgctcagcct ttccagttct ccaaatgaca ttgtccgcgg atcacaaata ataccgccct 3542581 tcccgccgcc gtaaggaaga ttggcaatcc cgcatttgag cgtcatccaa atggataatg 3542641 cctttacttc ctcttcatta acttctggat ggaagcgaac gccccccttt gtcggaccga 3542701 cagcatcatt gtgctgtgac cggtagcctg tgaacacttt gacgctccca ttgtccattt 3542761 tgaccggaat gcggacagtg agcattctct gcggctcttt catgagttca tacatatctc 3542821 ccggataacc cagcttccga agggcttcct taatgattgt ttgggtagac agaaataagt 3542881 taagagcttc tttttcttca tctttcgaga cttgctttgc tgacatcttt ttcacctcat 3542941 tgtttttttg gccggctgta atgtaagcgc tttaaaaaat cagcccgcca attcctttct 3543001 tcattggatt cacccttatc atcatgcaag atccgtacca gcttttgaat ccacaaaaaa 3543061 agagactgaa aacatctcag tctctgacta caaatctatc gattaacggg gatcaatcac 3543121 cagctgcgtt tcagcataaa aactgccgat tcccaaaccg tttactacat cgcctttaat 3543181 cgtgtaagtg cctgcgcgag gaagagtttt acgcaccatg acaaggtcaa attcggatgc 3543241 gcctaacaaa tcaagcgtaa gcgggagtct gactgttttt ccatcgttta aaatctgtgt 3543301 ttctttcagt gttcttccat tcactgaatc tcttgtcgta gcatgaaacc cgtcaggaaa 3543361 ttgaaattct accgctccaa gagaaagcac cgcatttggt ttatatgtca cttcaatatc 3543421 agaaatggtc cactctttcg tgctgttaac tgtttttgcc tcgattgatg cagactgtgc 3543481 atgagcttgg cccgaaggaa gtaagattga tagtaaaaca gctgaactga tgaataatga 3543541 agatacgaat gaagttcttt ttagcatgac atttccccct aattgattgt tgaaatttgg 3543601 ccagagcgtc ctctgcagaa aaagcgcttt ttcataattc gcgaattacc agttcttttt 3543661 cttaaaaatt aatctatcat cattttccat ggaagtaaat gttttttaag gaatattaac 3543721 acttggaatt caatgagaat tccttcctgt ttatacaagg ttcaaatgga cgatttccct 3543781 ctctttttct agtaacatct gcctgacatt ttatatcttt tatcctattt taaaaaaggg 3543841 caaaaaaagt cgaagatgcc tctgctcttc gattgatcac gttcctattt ttatctgaat 3543901 tcagtgttcc agttaaaacc gatcgtctca tcatcccacg gaattctttt ttcatcaggc 3543961 tgatccgggt tatacgacat ggtggtaaaa tagataattg tcagcggcgt ctctcccagc 3544021 actctatatc cgtgagccac cccttttggg attaataaca gcatcgggtt gtcttcgccc 3544081 atataataga cgtccgtttc tccttttgtc tttgaatcct ctcgaagatc gtataggaca 3544141 acctgagcgt ggccggttgg gaagaaccag agatcatcct gcttctcatg ataatgaaat 3544201 gccttaatca cacccggata gcttttcgac caagaggcct gcccaaaatg ctcaaggaga 3544261 ttctcatcgt cccggaccag ctcagcaaaa aagcctctgt catcgctatg cttcatcaat 3544321 tttttcacct tgactccatc aatcacacgc actgctcctt tcctgcaaat actctcgtaa 3544381 cgcttcccgc cagtggcggg ggcggatgcc ggcttcttca atagcccgat ggctcagcac 3544441 agagtatgcc ggacggggcg ttttgttccc gtattcctct gtcgttacag acaaaatggc 3544501 tgtttccagc ccgctttctt ccataattgc cgtcgcaaac tcataccagc tgcatatgcc 3544561 tgaattgctg acatgataga tgcccggcgg atggctgaac agcttgatga ccgcttctgc 3544621 taaatccttc gtataagtcg gcgaaccaat ttgatcgctg acaacccgaa gctcttgttt 3544681 cgtttcagca agtttcagca tggtttcaac gaaattactg ccgccatgtc cgtacaccca 3544741 cgatgtcctg atgatcgtgc tgtcttttgt cgttaatcgt atcagttctt ctccgagcct 3544801 tttgcttttg ccataaatgg ttttcggatc gaggggatcg tcttccctat atggctgggt 3544861 tcctttccca ttgaatacat agtccgtgct gatatgaaca tattgagctc cgatgcgggt 3544921 tgactcaagc gctgtataat aagcgccgat tccgttaatc aagtacgctt tatcaagctc 3544981 tttctcgcat tgatcaaccg acgtaaacgc ggcgctattg accacgatat ccggctgata 3545041 atggccaaac gaatgccgta ctgagcgctg gtcagcaatg ttcatcatct tctttgttaa 3545101 cgcaatgacc tcatatccgg cttgcttcag ctggcggcat agttccaagc caagctgtcc 3545161 tcccgcccca gtcaccaata cctttgtcaa tcagatcacc ttctcatcgg tcattgtctg 3545221 tataccactg aatcgtacgc gcaatgcctt cttcaaacgt cacttcctgc cgccagccca 3545281 gttcgttttt cagctttgat gcattgatcg catagcgccg gtcatgccct tttcggtctt 3545341 ccacgtgggc gaacaattcc tcacagccca gatgcttcaa aatgacactc gccagctctt 3545401 tattcgtgcg ttcatttccg ccgccgatgt tatacacctc gccgtcggtc cctttttcta 3545461 aaatcagctt gatcgcgcgg caatgatcct ccgcaaacag ccagtctcgg atctggagtc 3545521 catcgccata cagcggaaca ggcaggccct gcttcgcatg acggataatc gtcggaatca 3545581 ttttttcgct gtgctgataa ggtccgtaat tgttgctgca tcgtgtaatg atggccggaa 3545641 gcttgtgggt tttcacataa gacaacacga gcaaatcaga gcttgctttg ctggctgagt 3545701 atgggttatt aggagaaagc ggcgtcgttt ctgtaaacgc gggatcatcc gcttttaaat 3545761 ccccgtatac ctcatctgtt gaaatatgaa tcagcttctt ggcttttcct ttcaagaccg 3545821 cttccgccaa tcggtatgtc cccatgacat ttgtggtgat aaacggctcc gcttgggaaa 3545881 tgcttctgtc cacatgcgat tctgctgcga agtgaatgac gccatcgtag gtctcgtcaa 3545941 aagcgcggtc gatatcctcc tgaacgctga tgtccccttt tacaaagcga aaacggctgt 3546001 tttgctttaa tttttccatt tcctccgggt ggctggcgta cgtcagttta tctaaaacgg 3546061 taatgcgcgc atccgtttcc ctcagcatga gctttgtaaa cgtgagcccg atgaagccgg 3546121 ccccgcctgt aattaaatat gattttgcca tcacttttcg tcctgtcctt tccgtaaagc 3546181 ctggtgtaca agctgggaag cgagataaag cgattcgtga gttccggcat ctacccacca 3546241 gcctgataac acatcatacg taagctggct gttttcgatg tatagattat tcacatcggt 3546301 gatttccagc tcgccgcgct ttgatggtga tatttgttca atatatgaaa acacctctgc 3546361 atcatacata taaatgccgg taacacaaag gttggtcggt ggctgttcgg gcttttcgat 3546421 gatggaacga atccgcttgt ttttctcatc aatctcagca atcccgaaac gttccgggtc 3546481 atcaacttct ttcagaagca cttttgctcc tttcccctgc tgttcaaagc gttctgtata 3546541 aggctttaat gaatcttcaa atatattatc acctaataat aaaatgaaag actctttttt 3546601 cgtaaagcgc tttgcataag acagcccatc cgaaatgccc gatgctgccg gctgtacttg 3546661 ataagtgata gtaacgccaa gctcttcccc gttcccaagc agtttgtaaa attgcggcat 3546721 atgctccttt tggctgatga gtaaaatgtc ttttattccg gcttcctgca gcttcataat 3546781 cgaccagtat atcatcggat acgggcctac aggaagcaaa tgcttgttga cggctttcgt 3546841 taagggcata aggcgtgagc cgtttcctcc ggctaaaata acacctttca cattaacact 3546901 tccttacatg catttttata tctcttgttc atataaatct tgaagaatag ctgttacccg 3546961 tataatgcct ttgccatcca cgagcggcct tcctcccttg tgcaaagaaa ggcgaagagg 3547021 atagctgctc ataatgcgtg acatctgata gatgagtgtt tcatccggta caagctcacc 3547081 caatccaaga tcaagagcgg cgccttggtc agcaaatgtt ttggctgtag ccgtttgatg 3547141 ctcaacctga gaaagaacaa ggcacggcac gccgatgcaa atggcttcat atagagagat 3547201 gccgccagcg acaatggctg cgtccgcttg tttcatcaaa cctgccatat catttgtctg 3547261 ttcgatcatc ttgtactgcg gcttcttttc gatccgcctt cggactgcct cttgatgcgg 3547321 tgaagcgctc cccatcacaa acatcatgtt tttgtctttt atgtcgggga cttgatcagc 3547381 ggcagccagc actttaaaaa taagctgctt cggatcactt cctcctaatg caacaaggat 3547441 attgcggcag tctttcttaa gtgtgtaatc ctctcttgcg gcctgaaagg cggggtgaag 3547501 aataagatag tccggacctt catagatgcg tgtgtttccc tgaacgtaca ccctgcttct 3547561 gatgtcaccg taaattccgt taatgactgc gtcactatat tgaatcgatt taccgttttt 3547621 ctcttcaaaa agaacaattt tcgcatctgt ctccgtcttt attttcttta acagctctgc 3547681 aggcgcgcct agaatatcaa acaaaagcaa atcaagcttc ttgcttttta tttcccggag 3547741 aataaattcg tgctgctgca gctccggctt tacgatgacc tgccaatgct cttcatgaag 3547801 aaacgcttca gaatcctgat tcgtataaaa cgtaatcaag catcgctgtt tgagcccctc 3547861 cgcaagcctc ttcatccgga caacatggcc cattcccttt tcatagccgc cgtctgcgaa 3547921 gatcccaaca tgcatggcta gtcagcctct cgttcggttg ccgcatcggg gttccggttc 3547981 agaagggtga taagctctga ggcggataca tcggggcgct cgcctgcttt ttgatagagg 3548041 gcctttatcg attcatagtc ttcctttgta tcaatggtca gccgatattg aggggcgcga 3548101 aatcgttccg gcgcctctaa aaactgaaca cgataaagag ctggatgatt ccttatatat 3548161 aacgtgacat gctcctgata ttgatcctcc aaagcctgaa tacggctgat gtcaattaac 3548221 aggttggcgt tgaccacttc gccgcaaatc cctaatgggg cattcaggat atacgtataa 3548281 tccgagcctt gatcaaaatg cgcctgaatc attacatcga gcagctcagg atcgacaaac 3548341 ggattatcac ctgttaaccg gatgatgact gacggtttaa cagcttctat gaccttcaca 3548401 aacctatcga ggacacgttc ttcgctcccg cggaaaacac gaaagccttg tttgatacag 3548461 tgcgcctcta atatgtcgtc agtttctttg tcagacgtgg cgatgacaag attatcccga 3548521 tccttttggt aaaacgcgct ttgccggaca cggtgaacga gaatatcaag taaacgattc 3548581 gatccgagcg gccgaagcac ttttcccgga agccttgttg aacccattct tgcttgaatg 3548641 ataaagagaa tatcattcat gaaacgggct gtccttcagt aaaatgtcat cccagacaat 3548701 gcctgtgtcg gctggaatgt ctcttacagc ccgaacaccg ctggtcagca gttcaaaaaa 3548761 tctcgggtgc agcccctgcg gcttttgtcc gggccgaagc actgcgatat tgtcttcact 3548821 aaaggcttca cctttttgaa tcggagctgt tgtaaaaatg cctctgtatg caaagtttct 3548881 gatttctcct tcgatggcgg tcgttgtttt gtatgaactg ccaagcagtt tttcagagac 3548941 cggctttgtg atcccctgtt tcagctcagc ttccgttttc ctgatgccat cgaccatttc 3549001 tttcaattca tccggattta atgcaaacga gtggtcagca cccggcagat ttttatcgat 3549061 cgtaaaatgc ttttctatca gttttgctcc gagccgaacc gcggcacacg gcgcttctgt 3549121 cggatgctcg ctatgatcgg agaagccgat taccgcctca ggaaaagcgg cggcaagcat 3549181 cggaatgacg ctgaggttgc tgtactccgg cggtgctggg tatttcgcca cacaatgcat 3549241 tatggcaatt tgattgtttc cctctgccct gatggtgcgc caagcttcgt gaacatcaga 3549301 gatttcagct ccggctgtcg agaaaatcat cggcctgttc agccgggcga catatttaag 3549361 cagcgggaga tggttaattt cataggatgc gattttaaaa gcgctcggcg aggtagactg 3549421 aagcagatca gctgacccct cgtcacatac cgtacttaaa aagatcacct gcttttcgcg 3549481 gcagtaatcc aatagcggta aaatccactc agcaggcatt tccatagatt gaaccaaaga 3549541 aaaaatagag acgtccttgc ccgctgccgt cttgtacaaa ccaggatctt tctggtacat 3549601 cctatcagct tggaacattt gaaatttcac ggcatccgct cccgcttccg ccgcggcgtc 3549661 tatcagcgca aaagcctgat caagcttccc gtcatgatta atccccgcct cagcaataat 3549721 aaaaacagga gcgtctttgc ctacagtttt attcgcgatc tgaaacgctg ccattatttc 3549781 gcctccttgc ccggccaaat atgataatag taatacgatt gttcagcggt gaagcccatt 3549841 cgttcataaa ggcggatcgc ccttacattg tgaagctgcg tccccgctgt taccgttcta 3549901 tgcttctggg tctccggttg ttctatgaga ttcgccaata aatgaaacgc aatacgtttc 3549961 ccttcaaatc ccggctttac agccatcaaa tcgagaatgc actcatcatc tcttgataag 3550021 ccctgaagat agccgatgac ctcgccattg tgtttagcga caatattgac cgccgccctt 3550081 ccattcagat tgtttcgtgt ccactcctga aatatttcgt ttgctgcatc gcggctgaga 3550141 tgaggatcct gaaaatatct gctttttgta aacgagtctc gggccagctc acatatcgct 3550201 tctgtgtctc cgggctcagg cgggcccagt tcaaaaaatg gcggtgtttt gtcataaaaa 3550261 gacggaggca tcgccagctt cagcaaactc ccgacaaagt aagaggatgg ctgctgttgt 3550321 atcacatgcg cggctccgat atcttcagcc ggaacacgga caaagataaa atccgtttca 3550381 tccatttggc gtacagtata aaaagcttca aacagcctct ttagctgccc ggtactattt 3550441 gccgcaagaa gtttgacgtt catgactttc ttctgaagca ccttgctttc ccacaaagaa 3550501 tcttcgtaaa gcaatacgcc ttggagcctg ctgttttcaa aaaggccgag ggaaaattga 3550561 tacggaacat ccaatgtaag ctttctgctt tggagaaatt cctcaattgc ctctttggag 3550621 acattttctt ttaccgtata cacttaatca gcccctttta cgatatcccg cacagcttca 3550681 atgacatcat ctacatcatc gtcagacatt gatggataga gcgggagaga aagggttcgt 3550741 ttatagtaat tcatggcatt cggaaagtcc gcttccttat atccaaattg cttttgataa 3550801 tacggatgaa tgtgtactgg aataaaatga acgctagtgc cgatattgta ttcatccttt 3550861 aaagccgtaa tcatttcgct gcgcgtaacc ccggcctttt tttcatcaac ttgcagaaca 3550921 tatagatgcc aggcgtgcct gccgtcatca tggacaaacg gcgtgatcag cccaggaatc 3550981 tgctgaaaag cggtttgata gcggccggca atctcttctc tccgtttctg catatcatcc 3551041 agccgtttca gctgatgaag tccgagggcc gcctgcaaat caaacatatt catcttatag 3551101 ccgggcgatt cgacttcata gtaccagctg ccatttgaag aataacggtt ccatgcggct 3551161 ttactcatgc cgtgaaggct tagcacccgt atcttatcgg caagctcctc atcatcagtc 3551221 gtcagcatgc cgccttcccc tgtcgcgagg tttttggtgg cgtaaaagct gaatgccgtt 3551281 gcatccccga tagaaccgat cattctttgc ttataagtcg tatataccgc atgtgccgca 3551341 tcctccagca cgaataaacc atgattttgg gcaacagcca atattgcatc catatcgcag 3551401 gactgcccgc caaagtggac gggcacaact gctttcgttc gcggtgtgac ggccgcctca 3551461 agctttaccg ggtcaatatt gagcgtgttt tcgtcaatat ccgcaaacac aggcgtcgct 3551521 cccgtatgaa taatcgtatt ggcggtcgag ctgaacgtaa gcggagaggt aatgacctcg 3551581 tccccgggcc caatcccttt tgctttcaaa gccaaaaata aagctgcggt acatgaattc 3551641 accgccacgg cgtgcttcgc cccgacaaac gcggcaaact ctttttcaaa ctgctgaacc 3551701 ttcgggcctt tagagagcca tcccgattca agcgtttctg taacctcctg aatttcttcc 3551761 ttaccgatta acggcaatga gtaagggaga aaatgatttc tcttttgcac catttctttg 3551821 cgctcctatc attttattca gtatcttccc gcctgtaatc aacccctgtt ttggctttca 3551881 gttccgcaaa taaagcattt gttgattctg ccaccggata attagccgct atgaatgcca 3551941 ggcgcgcctc ttctgctttt tgatgcacgt cgggacttcg aagaacctca accaaggtgt 3552001 gcgccagttc atccggctgg tcaaacataa aatcgccaag agactcataa tacggatacg 3552061 agcgatttcc ggacgatttt cctatcagca caggcttttg aaacagcatg gcttcaagac 3552121 cgactgtcga ggtttgcgtc actgcggcat caacatacgg cagcaaatca taaagctcca 3552181 gctccttttt gatgactctg catgcttgat gttttttcgc cgcctcgtga tacagatcaa 3552241 gcttgttttt tccgatttcc cacgggtggg gtttgataat gatttgcagc tgcttctgat 3552301 cagaaagccc ctgcagcaca ccggaataaa agtcttctga aaagggctga gtggcaatga 3552361 gcacaatttt tttagtcggc tgaaaagcaa gttttcgata gaatatggac atatccatag 3552421 gcgttctgtt aaaaatctga tcgaagcggg gatgtcccgt tacgagaatc tgctcgggtt 3552481 tacagccttt tcgtatgaac cactctgctt catacgcacc aaaaacagct tgataggttg 3552541 taaaaacagg aatgaaggct tcatctccca tcaatgcgcc atgctgaaga caaatgctga 3552601 cggccccttt tctttgacac atgagagcga gcaccctgct gtaaatgtct tctgccgttc 3552661 cgacaataac agctgaaatc ttttcctgtt caaacagcgc atcaactgta tcaatggcct 3552721 ctataaataa aggaatatct ttgaaaagcc ggtcgcgaaa cgcttgatca ccaaatgccg 3552781 ggtgatcatc ataaggggcg agaagcgaac aggctgtttc gagatactgc ttcgaatcgc 3552841 ctttttggca tgaatccgca atctcccgct tgctaattac aggcagatca caataatgcg 3552901 gcaaactcca tctggccaaa acagccgttt tttcaggatc aaattgatag taattttcgt 3552961 ttgaaaaacg caggtaatca aagtgcaaaa tgactttccc tttaacaggt tcgtcatttg 3553021 ttttaacgat gttttggatt ctttcttcaa aaaacggctg aatctgtccc tcatcgatat 3553081 gctgatccac cgatccgaat aattccggtt cttcttccat catcaccctc agttcagggc 3553141 tgatgtattg ataaaaatta ctgataagcc caagcggaat ccctttgtag cgaagtttgt 3553201 caaaaagctc cacgtacttc cggtacagca cccaataatt gcttaaatag gccgacaagc 3553261 tctcacccca ttccaagctt ttttaatgat tcacgcagct ctcggcaatt tcgctgcgga 3553321 ggaaggttcc tgacaaattc atttttttct aattcaaaca gctgaaagtg aatcgattgg 3553381 tcggtaatat aattcaggtc cagctcctca tccagtgggt aaaacggata aaaatgattg 3553441 actctccaaa agaaccgggc atctcctata cggtaaaacg ccgggctttc atcccaatag 3553501 gagccaaact tctcctttac cttctcaagc accgaatacc tgtgcatcac cgagcaatga 3553561 tcaattgcgc acggcgcgtt ccatgtcact tgagcggcag gcctgacagt ttcttttaca 3553621 atgtcacgat tctcgtttaa atgataggtt ttggaggctg agtaaatcac agccttttca 3553681 ggatgggtat cgagctcccg caccattttc aggaggcggt ccggcatata gatgttgtca 3553741 tccgtcgcat aggtgatata ttcaccctcc gccatctcaa tcgcctgatt gatcagtgcc 3553801 gcgtatctcg ttttttctgt tctttccttc actccagata tatcgctttg ataaaaacgc 3553861 actcggttat cattcaaaaa aggacggatt acattcagcg tctcttcatt ggagttgtca 3553921 tccataataa acaattcaaa atctgaaaac gtttgtgaga gtatgctaga aatggacttt 3553981 gccacataat cgcttttgtt atagctcgtc ataatgactg atactttagg caaatcctac 3554041 acctccttct tggaacttca cacctgaaac tatcgttatc ttatgttgct tatgctcaag 3554101 ttgcgctagg gatacaaacc aatatgcgaa aagtttgtgt atgtttctga aaaacagcgg 3554161 ctgcccagag cgaaatctga tcggtccgct gttctttttc agcataatcc aagcatcagc 3554221 ctcataaggt gaaagagata aaaatcgcac cagcgactaa gatcgttttc catcggaggt 3554281 gagtcatcgc ggagcgttca cctatacatc cagaacatgt tttgaatggt tttcataaaa 3554341 aggaggaacg atatgaaacc gaaaaaaaat caatatcagc aaatgcaggc atttgataat 3554401 atgcaggggt atcagcctca gtttggcgcc aacccgtacc cgcagcaagg ccaaggctca 3554461 caaatgcaga caatggggat gcagccaatg atgccaatgc agcagggaca gcaaggacaa 3554521 caaggacagc agggatttgg attcccgggc cagcagcagg gcggcggttt tcaaattcca 3554581 tcggggccta caccgtcagg accgggccaa agcgttcccg gcatgctgcc tgttgaggaa 3554641 tcttacatcg agaatatttt gcgcctgaat cggggaaaaa cggccaccat ttatatgaca 3554701 tttgaaaaca gcaaggaatg gggctcgaag atttttcgcg gcgtcatcga agctgcgggc 3554761 cgggatcaca ttattatcag cgacccgaaa tcaggaacac gctacctgct cctgacaatc 3554821 tacctcgatt acattacatt tgatgaagaa attgcttata cgtatccata ttccatggcg 3554881 tcctattcgc caagataaga aaaaagccaa tcactcatat gatgaggatt ggcttttttg 3554941 tttatagata tttgacggct gcgacaacga tcataatcca agaaataata aacgccacac 3555001 cgccgagcgg ggtgatcgct ccaagaatgg agatttgcgt cacacttaga atatataagc 3555061 ttccggaaaa cagcacaatt cccgcaaaca tcagccagcc ggctgtcgtg acactgccta 3555121 tgccggataa tttatcagcc agaaacgcga caacgaataa cccaagggcg tgatacatat 3555181 gatactgcac gcctgtgtgc caaacctgaa gatacttatc aggtattttc ccttctaatc 3555241 cgtgagcgcc gaatgctccg agtcccacgg caagcagggc gttaatggcc cctaatatga 3555301 taaaaacttt catctatctc tcccgccttt tcgttaaact catatcattt atcttatcgc 3555361 acctgcacca aaattcaatg tttgttctcc gttgacacga gattgtcgga ttttctcctg 3555421 cgccaaagct ggaactggtc agctgctatt gcagcaagcg tccctaatac gagcccgttg 3555481 cttaatagag aaataaatac cggatgcaat ccctttaacg cagtttcagg aacaaacatg 3555541 ataccgaccc ctgtcagcag tgagataccg atgatagacc tcaccctttt tgattcttct 3555601 ttctcatatg aatcaaattc ggcaaaggcc agaccgccca ttgcggagaa cacaacaaaa 3555661 ttcaccgcaa atccaacggg tgacggcagg ctcgcaaacg tattcataaa aaacgggatc 3555721 acgctgatca cgataaccag aatactgccg agcataaacg gttttttaga aggcatcttg 3555781 gtcgtttcaa taaaacctgc ggctcccgaa atcggaacag gcgcaatagc tcccgtcaaa 3555841 ccgctaagca gatggctgaa tgaagctgca aaaccggcat ggcgttcatg atgctttcca 3555901 tcaggctgtt tgctgaattt tttcatggcg atgtccacga ccttcatgct cgccagcata 3555961 ttcacgatca gcaagatggt aataaaaata gaagtgatga tcaggccgct gttaaataac 3556021 ggggtcccaa aaggaaacag ggaaggcagc tgaaacagcc ggtccggcat ttcaatcggc 3556081 tttgcggctc cggcagccgc aaacagcacc cacccgccga acaaggctaa taaaatagaa 3556141 tattgcttaa aaaacatgat gttcgaattt gtcattataa aagcggcagc gatcacaaca 3556201 agcgccaggc caaatacaag accgtccacc ccgtcctgtc gataaccgat tccgagaatt 3556261 ccttttataa tgggctgact cagctgcatg acaagaagca ataaatagac gcccgttaca 3556321 accggagtaa acaattttgc aagtctgtca atgaccttga aaacacttaa caaaaagaaa 3556381 catacagcgc ttacaagaag agctccctgc aaaccccgca gtgtgtctcc atatgtcgca 3556441 aacacagttc ccgtcagccc tgcgtaaatc gtatacactc cccaccacaa gccggctggg 3556501 ctttcattga tcggcagtct gtggcctttc aaacactgaa tgacggcggc aattcccagt 3556561 acaaaaaaag tgctttgaat caatcttgca gaatctgagt gatccagatg aaacgactgg 3556621 gcaaccgcca ccggaacaac aatcgccgca gcaataataa acgctgtcca ttgcagcgcg 3556681 ccaagaacca atttcacgta agctcaacct ctctctttaa aaatcaaata aagactctcc 3556741 gtttccatcc tcttcctgct tctctttttc ttgctttcga tatttgttta atcccgcgct 3556801 ccccatcatt ttttccatca tcagctggtc tgtcgatggc ggcgcggcgg gacttggcgt 3556861 aacgctcggc tgtatgcggg gcgcgctcgc gttctccggc tgatcaagca cgacatcaca 3556921 cagagaacgg acaaccgcta cataacgctt cagctcctca tcccgttcag ccgtttttgc 3556981 tttttttagc tcttcttcca tcttttgaat caaagcagat atatgaatgt tcatgaagca 3557041 ccctccaaaa aaataaatgt tgtcttcctg cattttatca aattcctgct gaaaacgcag 3557101 atatgagttt gttatttttt ctgacaaacc ttgcgcgatt gacaagcaga agagattttt 3557161 cacataataa atcaccatac cttacaaaaa ggagaaacgg aatgaacagc atcccctcta 3557221 tcatcagcaa gcataaagcc tattttgcgg cgggacatac gagaccgctt gaatcgagac 3557281 tgaacatttt gcgaaagctg aaacaagccg tcagaactca tgaagccgat ctcatagccg 3557341 ctctctacca ggatctccat aaatccgagc aagaagcata ctcaacagaa atcggaatcg 3557401 tcttggagga aatcagcttt gtcatgaaac ggctgagaaa atggtccaag ccgaaacgag 3557461 tcaaaacgcc gttgactcat ctaggctcca aaagcatcat catccctgag ccgtatggaa 3557521 ccgttttggt gattgcgcct tggaactatc ccttgcagct ggcgctttct ccgttgattg 3557581 gcgccattgc ggcggggaac acggtcgttc tcaagccatc agaatatacg ccggctgttt 3557641 ctgctattct ttccaaactc atcagcagcg tttttccaac tgattatgtc gctatggcag 3557701 aaggcgggcc cgatgtcagc acagcattat tacagcagcc ctttgactac attttcttta 3557761 ccggcagtgt agctgtagga aaaatcgtca tggaggccgc cgccaaacaa ttaattcccg 3557821 taaccttgga gctcggcggc aaaagtccct gcatcgtcca taaagatgct gacattcagc 3557881 ttgccgccaa acgcatcgtc ttcgggaaat ttacaaatgc gggacaaacc tgcatcgcac 3557941 cggattattt atttgtccac gaggacatca aaacgaagct cacagaagaa atgaagcgtg 3558001 cgatcagaga attttacggc cctcagccgg aacggaatcc acagtacggc aaaatcgtca 3558061 gtgagcgcca ctatcagcgg ctgctcagct ttctgaatga tggcatcccg ctcacaggcg 3558121 gacaatctga tcccaatcat cacaaaattg cgccgaccat tctcgaacaa gtgagagatg 3558181 actctccagt gatgcaggag gagattttcg ggccgattct tccgctcttt acataccgca 3558241 atatcgggga agtcattgag aaagtccaat cgcgccctaa gccgctcgcc ctgtatctct 3558301 tcaccacaaa caaagaaatt gagcgcgctg ttttaggaaa tctgtcgttt ggcgggggct 3558361 gtgtcaatga tacgttaatg catgttgcga cgccgtattt gccattcggc ggcgtcgggg 3558421 aaagcggcat cggcagctat cacgggtttg acagttttaa cacattcacg cacaaaaaaa 3558481 gcgtcgtcaa acaaacgaac cgtttcgact tcgcatttcg ttatccttcc tccaaaaacg 3558541 ggctgcgaat gattcgaaaa atactcaaat aaaaaagcgc agatcacctg cgctttttac 3558601 aaatccttaa tacaccaatc aatcggcgcc tctcccattt tctccaaata ggcattcgcc 3558661 cgggaaaacg gtctgctccc gaaaaatccg tttctcgcag aaaacgggct gggatgcgtc 3558721 gattcaatga taaaatgctt ggaggtgtcg atccgttctt ttttcatttg agcatgccgt 3558781 ccccacaaaa taaagataac cggccgctct ctttcactca gcacgtcaat aattcggtcc 3558841 gtcagtcgct cccagccttt tcccttatgg gaattcgcct gtccgcgcct tactgtcagc 3558901 acagtattca gcaaaagaac gccttgcttt gcccagctca caagcgaccc gtgattcggg 3558961 atgctgcacc cgatgtcctg ctgcagctca agaaagatat tttttaacga aggcggctgc 3559021 tttacaccgg gcttgacaga gaagcttaaa ccttgagcct gtcccggccc gtgatacgga 3559081 tcttgaccca aaatgacgac cttgacatca tcatatgatg tataatgcag cgcgttgaaa 3559141 atatcccggc tgtccggata aatcgtttgc tccgcgtatt ccctcttcag catctctctg 3559201 agctcttgat aatacggttt ctcaaactct tcctttagct gattccacca gctgtcttgt 3559261 aaaagctgtt tcaagattca ggcctcctta cgaacgatga agtctggaat agacaggctc 3559321 gccatcccaa accatttcac tttttgcttc ccgcctcttc atctcaggct cttcaagcag 3559381 gacggcaaag tttttcgtcg gcagctcccc gagtccgtgc ttttcactta aacgatccaa 3559441 atattgcttc cgcttggcgc caaggtcagc agactgattg tctcccgcgt cactgaaggc 3559501 ataaatcacg ctggcgcaag ggacacgctt cacccggtaa tccttggccg cgcgcaaata 3559561 aaaatcccag tcccagtaat tgtgcacatc agcatcgaaa tacccgattt catcatgcag 3559621 aaaacgtctg tacatgctgc ccgacggcac gtatgtagaa aacactctca tatcctcata 3559681 gtcagcggta taagcaaaca atttccgtga cactggatac cttgttccgt ttttctcttc 3559741 aaacgaaact atttccgcat cagaatgaac gaagtctgcc gtttctattt cctttgccat 3559801 tttctcgata tgccctggcg taaagaaatc atcgtcatca cacagcataa tgcaatcccc 3559861 agacgcctct tttacaccgg catttctcgc agccacatgc cccgagttct tttctaaatt 3559921 gatgacagca atcggcagct ccggataaag tgctttgacc ggcacgaccg attccccggc 3559981 atcattcaca ataataattt catacggcat caaggtctgg cgggaaatcg actccaaaag 3560041 ctcacacaaa gccggaatcc gattataggt cacaattacg atagaaatct tcatgatgct 3560101 ctccttctca ttttcatagt catgtactat taaaacatat attggacggg agatcagtgg 3560161 gaatatccta ctgaaacggc atactacaat gatagaaaca gcaaagtggc tccgatcaga 3560221 agcaccatga tcagcatcag atctccaaag acatgaaaga tatctttcat gcggacgcca 3560281 ttcggaagga taagacgcca cagcttagat tgatagaccg gcagcagcac cagtgcataa 3560341 gaaagacaca aaaatgtaaa agccggcggc acaaaagcac agcctgcatc gtcccaattc 3560401 atcatgatgt ctttcatact agatccatcc aataaaaaca aagatatcat gagggctagc 3560461 aacacaaagg accccaattg aacctcaaac aggcgcattt tctggttata tgcaaatcgg 3560521 accgcccaaa accagacata agcatatgaa catagcagcg taagaatggc acctgctgta 3560581 aagacgacat caggcagccg atcaagcaga aaaacaaaag gcaagctggc tgccatagcc 3560641 aagagcatgc agccaccagt aaacaaaaat actgccccat gagctacaaa accatataaa 3560701 caagagctaa tcctcacgac atacacctcc tttacataga aattctatgt atatacctaa 3560761 aaaatcagac aagctgacgc ctgccaatat aacagcccat tcggccaaat aacggaaata 3560821 acagcgttgc aaaagcacaa gttccaacaa accaaggtgt caacaaggat tgaaacagcg 3560881 cagcaggaat tacattgaat agaaaaacaa gcataaaaat gacgtttggc accattgaga 3560941 tcagaatcgt atgtagaaca agcttttctc cgcgttttcc aaactccttc acgccttgat 3561001 acccaatcag cacccagtag atcatatatg cagctaagat cagccaaaca gaaacagaaa 3561061 tgcctttcca tactgcttga acaaacggtg attcaagcca tacatgcatt attgtaatcg 3561121 caatgccgac agcgaatagg gcactgttac agaaaagatg gaacatcaaa aacgcacgaa 3561181 acgttactgg ctgtattttc ttaaacgaag aaacaatgtc agttggtgtt ccaaacgcct 3561241 gcaataaagt ctgcatagct tcctcctcac tctttccttc ctgaaaagag cgaaacagat 3561301 gatgttcaat atggctctca atctcttcta tcatcgcctc accctcagga agccctttaa 3561361 gcccgctttt gatttcggat acatatgttt ctttatccat tttgtccgct ccacttcagt 3561421 attcggtcca tcatggctga aaatacgctc cattccttcg tgcgttccgc cagcacttct 3561481 ttgccctcgt ctgtaatccg gtaatatttg cggtccggtc ctttctcctg cttctcccag 3561541 taggaagaaa tatacccttg gcgttcaagc ttgtgaagag aaggatacaa ggtcccttct 3561601 ttcatctgca gttcatttcc gctgcggctt cccatttctt ttacaagctc atagccgtac 3561661 atcggccgct cgttcagaag cgtcaatacc aatataaccg tgcttccctt aaccagctca 3561721 cgatttaaca tctcaaaacc cctacctagt tttcttatgt agcattttac gaaagcccgt 3561781 tgagattgtc aaatgattcc tatagatctt ctatattgtg atacagagaa aatctaacta 3561841 taatgaaaga caaaacatga tggaggttca agacatgtct atgcataaag cactcaccat 3561901 tgccggctca gattccagcg gcggtgctgg gattcaagct gatttaaaaa catttcaaga 3561961 aaaaaacgta tacgggatga ccgccttaac ggtgatcgtt gcgatggacc caaacaacag 3562021 ctggaaccat caggtattcc cgatcgatac tgatacaatc cgcgcccagc ttgcaacaat 3562081 tacggacggc atcggcgtgg acgccatgaa aacaggaatg ctgccaaccg ttgacattat 3562141 cgagcttgcg gcaaaaacga tcaaagaaaa acaattaaaa aatgtggtaa ttgacccggt 3562201 tatggtttgc aaaggtgcta atgaagtcct ttatccggag cacgcccaag ccctgcgtga 3562261 gcaattggct ccgctagcca ctgtcattac gccaaacttg tttgaagcca gccagctcag 3562321 cggcatggat gaactaaaaa cagttgacga tatgatcgaa gccgcgaaaa aaattcacgc 3562381 actcggcgct caatatgtcg tcattacagg cggaggcaaa ctcaaacacg agaaagccgt 3562441 tgatgttctc tatgacggag aaacagcgga agtccttgaa agcgaaatga tcgatacgcc 3562501 ttatacacat ggcgcaggct gtacattctc agcagccgtg acagcggagc ttgccaaagg 3562561 tgcggaagtc aaagaagcca tttacgcagc gaaagaattc atcacagcgg ccattaaaga 3562621 atccttcccg ctaaaccagt atgttggtcc tacgaagcat tctgcactgc gcctgaatca 3562681 acaatcataa aaaaaggggc tgccttacag agaggcagcc ctttttaaat caccgaagac 3562741 ttttcacaga aaaaactgcc gatcccatcg gcagcctgtt tatttgattt ttaaattgtt 3562801 tgcagatttc ctcaaaaatg tttctatcga ctgaacaaaa agtgcatatt ccttcatttg 3562861 ttcatatgcc cgcgtgagaa tttccgccgt ttcactgtgc ggcgttgttc cgccaagcat 3562921 ttttttcagc tgaagcagca catccttata ttcttctcgc ttatcttcaa cttggttagc 3562981 agccttttcc aaacattccg gtgttatctt ctgttcatgt atattcaaga aaacaactcc 3563041 ttttacagaa aaaaatagta ggttatcgtt gaagaatagc acagatggct cagatttcac 3563101 ataagaaaat agaaggattt tctacataag tgtccaaatt ccgacattca tttcagattt 3563161 cccggtcgca ctggctgtta cttcatgatt tcccgggaaa ggaaaatatc ttgcactcaa 3563221 gacctcttct ccgttattga taaagatttc cacagatgac gcgtcgagaa acatgtgtac 3563281 ggtatgcaaa tccttgatgc ggcaatgtct cgcttctgtt ctttttccgt caaagctctt 3563341 tcgttccagc gtaacaatcc cctcgtcttt atggaaggaa aacgtagccg ttccgcggat 3563401 actgattgaa aagccagact ccgtatgaat gtcttccagt agaatctcag ttctttcagg 3563461 tttttccact ggaagcgcac cagatgatcc atgcatgttg atgtgtattt ttttctcatt 3563521 tctgcgcatg gcttttagct caggcagcgg ctgctgaatc agcttctgtc ctgaaagcgt 3563581 cagctgtctc ggcagcgtca tgcagtgaat ccagtggcag tcaatggtcg gatgggaccc 3563641 ttcatcctga tcaggcaccg ccatccatgc aaataaaatc cgccttccct gatcgtcttc 3563701 aagtgtttgc ggcgcgtaaa aatcaaaacc ttgatcaagc tccgtaaatt caccatgctt 3563761 cagttcaggc ttgttataat cgaggcggcc gacaaaataa cctgattgat atacgttctg 3563821 ataacggaaa ccgtcagcct caagcccttg aggcgaaaca atcagcacat ccgatccttg 3563881 aagggaaaac aaatcagggc attcccacat gtatccaaaa tcgtccagcc cgttgaagcc 3563941 cgcgccggtt atcgggccaa gaaatctcca ctctgtcagg ttatcagaag caaacaacac 3564001 agcctgccct ttcaaattct ctgtttgcgc accaatcacc atataccatg tgccttcatg 3564061 ctcccatacc ttcggatcgc gaaaatgcgc cgtatatcct tccggaaggc gggcgacgac 3564121 accctttttc tcaaaggaca gcccgtcgtc agaaacagca aggcattgat acgtttcccg 3564181 atttccatcc tgatccctga catttcctgt gtaaaaaaga tagagccgat cgtctttcgt 3564241 gacagcgctg cccgagtagc agccgttttt atcaaaccaa tcactcggag ccagcgcaat 3564301 ctcttcccgc ttccaattca caacatcctg tgtcgtataa tgcccccaaa attttgcgcc 3564361 gtgccccgtc tgaaacggct gccactgaaa gaatacatga tagctgccct tccaataaat 3564421 cacgccattc gggtcattca gcagcccaac cggcggcatg atatgaaaat gctggcggtg 3564481 cggatcgctg ttagcgatgg gctctttttt ctccacttct tcataagccc ggcgacgaag 3564541 ctcctggtca tgtgctgtca ttttttcctc tcctcatcct cattaatctt catgacaaat 3564601 gctgcaatga acgctgacac tgccgcaatc gccatgccaa tcagatagtg aatcaagttg 3564661 ctgaagccaa acggagccgc aatggcgatc atcggaattc ccgttaaccc gtaagcgttt 3564721 gcagctacat gtgtaaagac gacatatgcc ccacccaatg cgcctccgat catcgcggcg 3564781 ataaacggtt ttcggtagcg cagattgact ccgaatatga cgggctcagt aatgccgaga 3564841 aaagcggaaa atgctgccgg aagcgcgatt tcttttgtct ttgccttttt cgccataaag 3564901 aagacggcaa gacctgcccc gccctgtgcg acattcgcca ttgaccagat cggcagcaag 3564961 tagtttttgc ctatatctgc aattagccct gcctcaatcg catggaagct gtgatgaacg 3565021 cctgtcagca cgatgagtga atacgtgccc ccgaaaatca gacctgcgac aaaaccggca 3565081 tggtcatata cataagttaa agcaaccgta atgccggagc caagcgctct gcctagaggg 3565141 ccaatcgcga taaaagcaac aaacccggtg acaatcacag taacaaatgg tgtaacaagc 3565201 aaatccaccg catgtggaac cacttttctc gtccatttct ctaccttgct catcacatac 3565261 accgcaagca ggacagggat aacagttccc tggtagccga gaagagcgat atcaaatccg 3565321 aaaagatgca tgtaatcagg tgtcgcttcc gccaatcccc atggatttaa aagattcgga 3565381 tgaatcatga ttcccccgat gaccgctccc aagtatggat tgctgccaaa ctcttttgaa 3565441 gcgctgaccc cgattagaat cggcaagaaa atgaatgctg cacttgaaaa catatcaagc 3565501 agctgcaaaa gcgcagaatc cttgctcatc caatgaaacg cattgatcat acccagcaat 3565561 cccattaata ggccgctggc tacaatagct gggatgattg gaacaaaaat attagaaagc 3565621 gttttcgcaa atctcgcagc gggattcagc ttttcttttg ccgcatcctg atgattgacg 3565681 tgttcttcac gctcgatatc agcttcttta gaaaaggcat cgaatacttt attcacaagg 3565741 cctgttccga aaatgatctg gtactggcca gagctgctga aagccccttt aacgccatca 3565801 agctcttcta cttgtgcttg atctatcttt gattcatctt tcatcactaa acgcagtctt 3565861 gttgcacaat gagccgcgct gataatattt tctttccctc cgagaagctc aatgaggcgt 3565921 tttgcagtct ctttgtaatc catctatttc tccccctttt atttaaacaa aaaagaccta 3565981 aaattcgcca acgaataaag gacacagcga tcctttttca tttacgcaaa ttttaggtct 3566041 tgcctgcttt accagtcaca atcccgctta ttcagattaa gaatacgctt tcatcataaa 3566101 tcatgatagc gttttcgtca actatttttt tagttaaata gtttgatata acatgtagac 3566161 aaaaattcgt aaaaattaat tgtgaaatac ttcacaatat cgtgctatac tatgctcaat 3566221 catgaaagaa agcaggaaaa gacaatggaa actcaagcat tacaaaaggt tgaacagtat 3566281 gctttgaaaa aacaaaacat attcgcttca agcaaaatcc gttatgtgct tcggtccatt 3566341 ttggccagta tatttattgg ttttggcatt acagccgcaa gcaaaacagg cagctatttc 3566401 tttatggctg attctccgtt tgcctttccg gcagccgctg tcactttcgg ggccgctatt 3566461 ctgatgattg cttacggagg cggagattta tttaccggca acacctttta tttcacctat 3566521 accgcgctcc ggaaaaaaat cagctggcgc gacaccctat acttgtggat gtcaagctat 3566581 gccggcaatt taatcggcgc cattctgttt gccatcctga tcagcgcgac gggacttttt 3566641 gaggagcctt ctgttcattc ctttttgatt catttggcag agcacaaaat ggagccgccg 3566701 gcttccgaat tgtttttcag aggaatgctg tgcaattggc ttgtgtgcct cgcctttttc 3566761 attccaatgt ctctcaaagg ggaaggagca aagcttttta ccatgatgct tttcgttttc 3566821 tgcttcttta tttccggctt tgaacacagc attgccaata tgtgcacatt cgccatctcg 3566881 cttttgatcg agcaccctga tacagtgaca ctgatgggag cagtcagaaa cttaatcccc 3566941 gttacgctcg gcaatctgac cgcgggaata gttatgatgg gctggatgta ctacacactg 3567001 aatcctgatc aataaaaaaa cttccagaga tcactccctg caagtcaaag cggttattcc 3567061 gagagatctt gaagacgctg gacatgcagc gtgatatagc cggcctcgga ttccggcaaa 3567121 tgtaattgat attcattttt caaaaactcc gccagctcca gcgcacattg ataggcgaat 3567181 gaatactttt tttggatgaa ataaagcatc tcctcgtcca tacgatggag cgcttcattt 3567241 gattccaacc ggctgaccgc gtatcgcaaa tgcgtgacaa ggcgttgata ggaaatgctg 3567301 ttttcatcca cctttcgatt aaagtattgt tttattttct ctatcatttc tttgatcatg 3567361 gtcgtatgct tcagcgctga atacatgctc tccgcatcca tcttcgccgt atggatgtga 3567421 agggcaatat aacccgcttc atcttcaggc agagacacgc ccaatgtctc ttttacatgt 3567481 ccgatcgccc acaggccgat ctcatattct tttttataga gcgcctttat ctcatgcagc 3567541 aatttattct gcacaagcag cccattttga atcctttcga tcgcaaagga caaatggtcg 3567601 gaaagcgcga tatgaatgtg atcgctcagc ggcgccgcga gctctccttc cgcatagctg 3567661 atgatatcct cagctatttc tatatgctcc tccggcagtg tttgcaggat ttgtttgaac 3567721 ttttcattct cgtcgcgcac gacaaagatc ttttccactt tattcatagg gatgagatca 3567781 tttttctttt tttgaaaagc gattcccggt cccatcacga ttttttcctg atcatcctct 3567841 tttattaaag ccgcattgtt gtttaatact ttatagattt tcaagaggtt atctctcccg 3567901 ccaatttgct tttgactggg attttacctc cttttgaccg ccatgtaaag atgcgggccc 3567961 gctctctcct gctttggcga ttccttgaag gcttgcaaac atcttctttt ataaagcgcg 3568021 gcggctttcg ctttctgctt ttcttcctca ttcacagcca tccgccattc ataaaacgaa 3568081 acgagtcctg cggcctgcac agccgccttt ctttggtatg tacgctgagc cgaatagacc 3568141 gcggcagccg cagtttttct gtccggcgtc acccagttca tcaaaaagac catccacacc 3568201 cgtaaagata caagcaaacg tttcatagaa aaacatccct ccgcttcttt ttggcaggca 3568261 gcctttttag cagcccgttt tctcagccgc agcccgcaag aaaagacggc cgatttcttt 3568321 tctcgcaaac tagcggctct agcaaaactc atgactctat gatagaccgt ggaaagagaa 3568381 ttctttgtca caatatgagt gaaaaaacca actagttttt agaagttttg ttgaaagctg 3568441 aaagaattga aatgaaaatt ggagaaccgc tttgaaaact ttatacacaa gttatcccaa 3568501 agataagaac aacttaatca caagagatat ccacatgtcc acaaactcta tctatatttt 3568561 gtatacgaac gtatattcct aactatatat atacacaggt ttattcactt atacacaggg 3568621 ttctgtgtat aactccttcg ttatacacaa acaaaatcca ataaatggtc caaatgacac 3568681 aaggattttt ttgaattttc aagaaatata tactagatct ttcacatttt ttctaaatac 3568741 aaagggggaa acacattgaa aaaggggatc attcgctttc tgcttgtaag tttcgtctta 3568801 ttttttgcgt tatccacagg cattacgggc gttcaggcag ctccggcttc ttcaaaaacg 3568861 tcggctgatc tggaaaaagc cgaggtattc ggtgatatcg atatgacgac aagcaaaaaa 3568921 acaaccgtta tagtggaatt aaaagaaaaa tccttggcag aagcgaagga agcgggagaa 3568981 agccaatcga aaagcaagct gaaaaccgct cgcaccaaag caaaaaacaa agcaatcaaa 3569041 gcagtgaaaa acggaaaagt aaaccgggaa tatgagcagg tattctcagg cttctctatg 3569101 aagcttccag ctaatgagat tccaaaactt ctagcggtaa aagacgttaa ggcagtgtac 3569161 ccgaacgtca catataaaac agacaatatg aaggataaag acgtcacaat ctccgaagac 3569221 gccgtatctc cgcaaatgga tgacagtgcg ccttatatcg gagcaaacga tgcatgggat 3569281 ttaggctaca caggaaaagg catcaaggtg gcgattattg acactggggt tgaatacaat 3569341 cacccagatc tgaagaaaaa ctttggacaa tataaaggat acgattttgt ggacaatgat 3569401 tacgatccaa aagaaacacc aaccggcgat ccgaggggcg aggcaactga ccatggcaca 3569461 cacgtagccg gaactgtggc tgcaaacgga acgattaaag gcgtagcgcc tgatgccaca 3569521 cttcttgctt atcgtgtgtt agggcctggc ggaagcggca caacggaaaa cgtcatcgcg 3569581 ggcgtggaac gtgcagtgca ggacggggca gatgtgatga acctgtctct cggaaactct 3569641 ttaaacaacc cggactgggc gacaagcaca gcgcttgact gggccatgtc agaaggcgtt 3569701 gtcgctgtta cctcaaacgg caacagcgga ccgaacggct ggacagtcgg atcgccgggc 3569761 acatcaagag aagcgatttc tgtcggtgcg actcagctgc cgctcaatga atacgccgtc 3569821 actttcggct cctactcttc agcaaaagtg atgggctaca acaaagagga cgacgtcaaa 3569881 gcgctcaata acaaagaagt tgagcttgtc gaagcgggaa tcggcgaagc aaaggatttt 3569941 gaagggaaag acctgacagg caaagtcgcc gttgtcaaac gaggcagcat tgcatttgtg 3570001 gataaagcgg ataacgctaa aaaagccggt gcaatcggca tggttgtgta taacaacctc 3570061 tctggagaaa ttgaagccaa tgtgccaggc atgtctgtcc caacgattaa gctttcatta 3570121 gaagacggcg aaaaactcgt cagcgccctg aaagctggtg agacaaaaac aacattcaag 3570181 ttgacggtct caaaagcgct cggtgaacaa gtcgctgatt tctcatcacg cggccctgtt 3570241 atggatacgt ggatgattaa gcctgatatt tccgcgccag gggtcaatat cgtgagcacg 3570301 atcccaacac acgatcctga ccatccatac ggctacggat caaaacaagg aacaagcatg 3570361 gcatcgcctc atattgccgg agcggttgcc gttattaaac aagccaaacc aaagtggagc 3570421 gttgaacaga ttaaagccgc catcatgaat accgctgtca ctttaaagga tagcgatggg 3570481 gaagtatatc cgcataacgc tcaaggcgca ggcagcgcaa gaattatgaa cgcaatcaaa 3570541 gccgattcgc tcgtctcacc tggaagctat tcatacggca cgttcttgaa ggaaaacgga 3570601 aacgaaacaa aaaatgaaac gtttacgatt gaaaatcaat cttccattag aaagtcatac 3570661 acacttgaat actcatttaa tggcagcggc atttccacat ccggcacaag ccgtgttgtg 3570721 attccggcac atcaaaccgg gaaagccact gcaaaagtaa aggtcaatac gaagaaaaca 3570781 aaagctggca cctatgaagg aacggttatc gtcagagaag gcggaaaaac ggtcgctaag 3570841 gtacctacat tgctgattgt gaaagagccc gattatccga gagtcacatc tgtctctgtc 3570901 agcgaagggt ctgtacaagg tacctatcaa attgaaacct accttcctgc gggagcggaa 3570961 gagctggcgt tcctcgtcta tgacagcaac cttgatttcg caggccaagc cggcatttat 3571021 aaaaaccaag ataaaggtta ccagtacttt gactgggacg gcacgattaa tggcggaacc 3571081 aaacttccgg ccggagagta ttacttgctc gcatatgccg cgaacaaagg caagtcaagc 3571141 caggttttga ccgaagaacc tttcactgtt gaataagaaa aagccctgcc gattcggcag 3571201 ggctttttaa agatcagtca gcaaacgcct cctgcaataa gcgatacgat cggagcttat 3571261 cttcaaaatg atgcgtgatg gtcaccacca tgatttcctc tgtttcatac gcgttactca 3571321 aagctaacag ccgctcctta acctgttctt tcgtaccaac aatcattcga tttcgattat 3571381 cagcaattcg tctctgttca taaggagaat acgtattttt ccgaacagct tcatacgaag 3571441 gaactccctc taaaggaata ccctgctctc ccgccaaaag tgtaaaatca agcacagccc 3571501 caagctcctc tgccttctcc tccgtgtcag cacaaagaac aaaaacagca actgccgctc 3571561 gaggcgtatc tcctaacaca gacggtttga atcgcctctt atactgtctg acagtaccct 3571621 ctccgccctc tccattgata aaatgggcaa acatatagcc agcgccagat tcagctgcga 3571681 gcagcgcgct ttctccagat gagccgagca gccacacatc cggagccgtt gaaatatgcg 3571741 gcgcagcggt cagattcgga aaacggtgtt tgtcatccgc caaatcatgc aaatacatgg 3571801 tcagctcctt aatttgctgc ggatactgat cagcattgcg cttaccaccg tcattcagcg 3571861 cccatgatgc aatcggcatt ccccccggtg ctctgccaag ccccaggtca attcttcctg 3571921 gtgtcagccc ctccagaaca cgaaagtttt cagctacttt ataagcactg taatgcggca 3571981 gcatgactcc tcctgatcca acacgaattc gctttgtttt cgctgctata tgactgatta 3572041 gcacctcagg actggaccct gccagccgtt ttgaaaagtg atgctcagaa acccaaaatc 3572101 tcttatatcc aaggtcctca gcagcttggg caagcgcaac ggtttgctgt aaggccgttt 3572161 ctgcattgct gccctctgat actggagatt gatctaatat acttaatgaa accatcccta 3572221 ccacctcatc ctcatcgtat cactgatccc ctattttttc tccaaagccg ctcacactgc 3572281 ttatcagtgt cccctatcat tcgccattta tttgtgaaag catgtcccta tttgtcggaa 3572341 tatgttacac gtgaaacata aaaacccctc cagacggaga ggtttgcttt agtttttatt 3572401 aaagcccttt tctttcacgt agtcatttaa atacgtacgc ggcttttgct tcataaagtt 3572461 cagtatttga tcggaccacg tttcttcccg cttcccgttt gttctttctc tatagtaatc 3572521 agaaatggtt ttgtcatacg tattcatagt atgacggaaa tcgtctgtgt tcacattata 3572581 cgtattttca tgataaacgg cctgctttgg caatctcggt tttttgccgg aaaggttcgc 3572641 aggatggcct actgccagtc cgaaaagcgg gagcacatgg tcaggcgttt gcagcacctc 3572701 tgtcaccttg tccaattcat tccgaatgcc gccgatatag caaatgccaa gccccatgga 3572761 ttcagcggca atgctcatat tttgcgctgc cagcgccgca tcaatcaagc taaccataaa 3572821 catttctgta ttctcgagca gctcagaaat atgttcacct ttttcctcag ccagttgttg 3572881 atggcggtac aaatccgcac aaaatacaaa aaagtgtccg ttcttctcaa cgtaaggctg 3572941 attcccagca agcacggaca gctcacgttt tttctcagga tcagaaaccc cgataatcga 3573001 atatgcctgc acatagctgg atgtagacgc agcctgcgca cttttcacta atgtatcaat 3573061 ttcttcagct gtcaaaagct gatcagtaaa agaccggatt gaccgatgat tcaaaatggt 3573121 ttcgattgtg ttattcatca caaaaacctc cttatcactt tttatcatat ccgaaaaaaa 3573181 gtgatctcaa aagtgaaatg ctctgcacaa aaaaagacag cctctgtaaa ggctgtctgc 3573241 atatcaagaa ttaaaaagat aacttctgta tttcgtcagc tgcacacttg cattatatac 3573301 aatcccaaat ccgattaacg tggaaagtgt cgagcttccc ccatagctga caaacagcag 3573361 cggaatcccg gtaacaggca taatgccaat gttcattccg atattctgga atgtgtggat 3573421 cacaattaac gccgtatagc caacgcaaaa gaaagaagcg aaacggttaa acggatgtat 3573481 tttgtctatc agaacaacaa gcctgtagat taaaaagaag aacatgatga caacaattgc 3573541 acagcctata aagccaaatg actcacctat tatagaaaag ataaagtcag tcgtactctc 3573601 tggaacataa accttcaaat tagaaatacc attacctaaa ataccaccag atcctattgc 3573661 catgatggcc tggtcaactt gccagctgtc atttgaatct tcctgtgtct catttgaagc 3573721 agacacccaa gaagtgaccc gcttaatttg ataatcctgt attccaactg atttagcaac 3573781 gtcaggaaag tttatcatta ctaataaaat taatgaaatg agtaagatac ctgaaccagc 3573841 tatgatcgca atcaatttcc aatttatccc tgacataaaa accattacaa gaacgataaa 3573901 catacatatt cccgcagtcc cagcatcctg catcaggata agacctacag gaataactgc 3573961 gacacccgca atctttaata acaagtggat atcatcccta agcgtccgaa ctcctttagg 3574021 atttgctttt ccaataactg aagcaagcat cataatcaaa ccaaccttca taaactctga 3574081 cggctgtatt gttattctac cgatcctaaa ccaacttttt gcccctttaa taacaggtgc 3574141 aatagactcg ggactgattt taagaataat caaagataaa ataccaatga taaaaatata 3574201 taaacttaac ttttcaagct gttctaaatc aaagtacaaa agaactgtaa tggctacagc 3574261 ccccaaaaga taaaacacaa tttgctgaat ccaatccgtg ttcccatact gcccaaactg 3574321 accggcagca tatattgata ctacgcttat aataaaaaac acaccaaata taaaaatcaa 3574381 atccccctgg taaaaggggc tttgctgttt cttatatcga ctcattctat cccgccttac 3574441 attttcatcg gaaaatcact aatgtttatt atacatgaac cacgttcaag atgacacgtg 3574501 aagctcgctt ccttttatgt tttttcagca tttgcggcgc tttttcagct acacgaaata 3574561 tgacgtatca taaaccgaaa tgtttcgatt gacacaaaac ttttcaaatg aaaaaaacgc 3574621 cataccaata gaatttgtta aaaaacgaat gcgataatgt gttatgttcc caaataatgt 3574681 gatacctcat atagaaatag ctaaaaattc agagccccat gcccatacat tctcctagca 3574741 cattaaacga aaaaataaga cgatagatcc agtccatttc tgcaaaaaca cgtatcaatt 3574801 tctggaaaac atggtataat aattgtaaca gaatgttcaa aaaacaatca caaaacagac 3574861 acaactcagt tcctctattt catttttgta aacgttatca caaaatgaaa ggagacgggt 3574921 atgatggaca tgttttttgc ttacttattg gttgccagcg caacgcctct ctttatttgg 3574981 cttgataaca aaaaagtcgc actctcagct attccgccaa tcattttaat gtgggtattc 3575041 ttcttctttt acgcaacaga aagcctttct ccacttggac acactctcat gattatcttg 3575101 tttgccgtta acgtcattgt cgctcatatc gccgcattta tcatttacgg ccttccgtat 3575161 cttcgcagaa agcgaagcag ctgaagacag caaaaaaccc tcttccactg aagagggttt 3575221 tttgtattat tcgttatggc ctgaatgctc tgagtgttca gcgcctccag gaggatttcc 3575281 gtccatatgg tcaccatggt gatagtgagc cgcgaaaatc cagatggatc caagtacgat 3575341 aacgatcgcg ccaaagaatc cgaacagcgt gtttccgact tggatcgtgc cgttttcgct 3575401 ctctgtcata tgcatgaaca tgagaagctg cagcgccgcc tgaatgaagg cgaagccgaa 3575461 gataatccaa agttttgctg atgagctcag gtcagtatac actgcaaccc atagagccag 3575521 cagggtcaaa acgatagaca ggataaaacc tacaatgtgt ttccatggaa agtgactgtg 3575581 ttcagcagat ttgtttgcca ttttacagac cccccaatcc catgagatag acacctgtaa 3575641 agatgaaaat ccatacaaca tctaagaagt gccagtacaa gcttgagata aagattttag 3575701 atgaagtttg cggagttaag ccgcgtttct tcaactgaat cagaattcct gtgatccaga 3575761 aaatcccgat tgttacgtga gttccgtgag ttccaagtaa aacaaagaat ccagaccaga 3575821 acgcacttgt actgagagcc gctccttcat gtacatagtg aacaaactcg ttgatctcgc 3575881 atccgacgaa gccggcaccg agaagaagag tgataattgt ccaaatgact acgcctttta 3575941 aacttccgcg gcgcatttca tgaacagcga tcccgcaggt aaagctgctg atcagcagca 3576001 agaacgtcat aatcattacc agattgactt caaatagttc gtctggcaag acacctccag 3576061 ctgttctgtt tttaagaacg aagaaggttg caaatagtgt tgagaacaac acaatttctg 3576121 cccctaaaaa gatccaaaac ccgagaatat taagtctgcc ggtttcagat tgatattcca 3576181 taggcgcgtt agaattgccg tgttctgcat gttccataac tcacgcctcc ttattcggaa 3576241 atctttcttt ccgtctcttt tatttcatca acactaatgt agtagccgtt gtcgtattcg 3576301 aatgaacgca gaaccatgca gagcaggact ccgatcaatc cgactacgcc catccagtac 3576361 cattcaaaga caagtccaaa gcctgcgaga ccgaaggcaa cagacataaa gaacggtctg 3576421 cctgagttgc ttggcatatg gattttcttg aatttgcttt cagggtataa ttcagttttt 3576481 tcttctttca tatgcaggaa tgcatcttga gatttgactt caggaagcac cgcaaagttg 3576541 taatgcggcg gaatcgcaga agaagtcgcc caatcaagcg tacgtcccac accccatgaa 3576601 tctccgctga tttcacgagt agagtaacgg aagctgtagt agatgttata gcaaaggatt 3576661 aagaatccta cacccatcat gaaagctccg actgttgaga taaagttcaa tgttgtccag 3576721 ccgtcattcg gtccgtatgt gtaaatacgg cgcggcatgc cttgaagccc caagaaatat 3576781 tgcgggaaga aacaaatatt gaacccgatc ataaagatcc agaagaacca ttttccgatt 3576841 ctttcgttca gcttgtggcc gaacattttt ggataccaga aaataaatcc ggcgaaacaa 3576901 gcaaatacag tacccgcaat cagcacatag tggaagtgag atacaaggaa gtacgtatta 3576961 tggtattgat aatccgctgc tgccatcgca agcataaccc ctgtaacccc gccgataacg 3577021 aagttaggaa tgaacgcaag cgcccacagc ataggtgttg taaagctgat tcggccttta 3577081 tacattgtaa agagccagtt aaagatttta accccggttg ggattgagat tgccattgtc 3577141 gtaattgaga agaatgagtt aacggacgca ctgttcccca ttgtgaagaa gtggtgagtc 3577201 caaactaaga aactcaatac agagatggcg ataatagaac caaccatcgc tttgtaacca 3577261 aacaattgtt ttcttgcaaa gcttgagatg atttctgaga aaataccaaa cgccggaaga 3577321 ataacgatat atacttcagg atgtccccaa atccagaaca agttagccca aagcatcggc 3577381 ataccgcctg cttccaatgt gaaaaagtga gcgccgaaca aacgatcaaa tgataaaagt 3577441 gctaatgcta ctgtaagtac agggaacgca aacacgataa taaccattgt gatcagtgtt 3577501 gtccatgtga acatcggcat acgcattaat gtcatgcctt ttgttctcat ttttaagatt 3577561 gttaccataa agttgatccc tgtcatcagg gtaccgatac cggcaatctg aagtccgagg 3577621 aggtagtagt tctcacccgg cccagggctc atgtcgttac ttgcaagcgg catataactc 3577681 gtccagcctg cgttcggaga acctccgata acgaaagaaa tattgaaaag catcgcccct 3577741 acaaagaacg tccagaagct caggttgttc aagtaaggga acgcaacgtc gcgggcaccg 3577801 atttgaagag gcacaacaac gttgataaga ccgattaaga acggcatcgc catgaagatg 3577861 atcatgattg taccgtgagt tgtaaaaatt tcattatagt ggtttgagtc taaaaaactg 3577921 ttattcggaa gcgctagctg ggcacgcatc atcagaccgt cgacaccgcc acggaataac 3577981 ataattacag cagatataat atacatgatt ccgagttttt tatggtcaac agtagttatc 3578041 cattcagacc acagccattt ccactttttg aagtaagtca gaacaaaaat aatggcaatg 3578101 gttgaaagcg caatggaaac ttgtgcgccc agaattaatg ggtcaccagt tacgaaaaat 3578161 tcgtcccatt tgaatttcat gcaggcttcc tcctttcctg atcaatatca ttcttctgta 3578221 tcatcagact tcttaaattc gtttttcttt acgttttcaa acggatctgt tttagaatgc 3578281 ggtgaaacgg cttgatagcc aaggcgtttg cgcgcctcca tcgcgtactc agcgtcttgt 3578341 ccgtgatcaa cgtatttcaa gtgagtagaa gagaacgtta attcgtccac attttcagga 3578401 agcatcaatt catcatactt ctcttttgtc agcttaggag cctcgttctg agtctttttc 3578461 acccagctgt taaagtcttt ttctgtgact gcattcacat caaactcttg gtctgcaaaa 3578521 tgttcacctg tgaagttcgc gttgcggcct tcgtaagtac ccactttgtc agcctgtaag 3578581 tattgatcca tcagcattcc tgccatcgca tatttttgcc ctccaagctg aggaatccat 3578641 agcgaagcca ttgaatctgc agatgagatt ttgaacaaga tcgggcggtc gacaggaatg 3578701 tttaagtagt tgaccgtttc aatatcctgt tcagggtagc taaataccca tttccagtct 3578761 accgaagtag cataaacaac aagaggctct ttgtcttttg ttgcttcagg agctttttct 3578821 aacgaatata tcgtctgtac tgttggcaca gaaagtgcaa tgacgattaa aattgggatc 3578881 actgtccaga ctacttctaa aaacgtgtta ccgtgaattt ctgggttata agatccatta 3578941 tctttgcctt tacggtcgcg gtattttact aaaataatgg taaatagaac aaagacgacc 3579001 ccgacgataa acagcataaa tccgatagat aacaggatta aatcactttg ctgttcagct 3579061 acaggtcctt tcggatctag tactgaagca ttgctgcatc ccccaaggac gaaaaccaca 3579121 gttaacagcg ctaatacaag caacggtttt aatgctctga acaagaagat caccatcctt 3579181 cctattgatg taataaatct gaagtgcata cttcctcaaa atcttttctc tactttgtta 3579241 tgctatcaaa aacttcactt attagcttta tttttttata aacttcatcc cattttcgct 3579301 taaatgtcat aaaatcgaca aaaattgctc caactttatt cacatctatc gcttaagatg 3579361 aaaagtttct agttatttcc gcatataaag taaagaaaga tgatgaagaa ctaattctga 3579421 caaattaagg tttaccacaa taaaaaactt aggtcaatca aaaatttcat tttgttaaac 3579481 tttctagata ggaattattt tttcctcgtc tagcatcttt tcacacggtt accattttaa 3579541 cgcatcaaat attgaaagaa aaggcgcaat gaagagccaa tatgctctga attgtccgta 3579601 tttttttatg agagcatcca gttgtttatc ttatacaaaa aagaggaatg atataagcaa 3579661 ataaataaaa aataggatgt gttgcatgat gagttttctt atttcactta tcgtcgctat 3579721 tattatcgga tggcttggaa gcctgtttgt aaaaggagat atgcccggag gaattatcgg 3579781 gtctatgatc gcaggtctta taggcgcctg gatcggacac gggctgcttg gaacatgggg 3579841 gccgcaccta gccggatttg ccattattcc agcggtaatc ggcgcagcca ttgttgtctt 3579901 tctagtaagc ctgttaacca gaaaaagagg ataaaagcag cagcacccga agcgtcagcg 3579961 ctttgggtgt ttgttttgcc ataaaaatcg aaaaagcctc aaccctagcg gttgaggctt 3580021 ttgactggtt tggcgcccaa ctgatcgatg aaccttctga aggcctgttt tccctctgct 3580081 gtctgcttaa atacaccggc gtgttcaagg atgcgcgcga atacatgtcc cagctcttct 3580141 tttatgacta gatctacgtt ctcttttgtt atggttcttt tttccatcgt ccgaagagcc 3580201 cactcactat gctttgcagt gagcggattt tgttctaagg ctgttttcgg atcagcagaa 3580261 catagcgccg ctgccgtttc tttcatttcc tcctgtaagc ggccaggcaa tatcgccaat 3580321 cccatgacct caatcaggcc gatattttct tttttaatat ggtggacttc ttgatgagga 3580381 tgaaatattc ctaatggatg ctcctcatcc gtccggttgt tcctcagtac gatatcgagt 3580441 tcgtacaagt ctcccctgcg ccgcgcaatc ggtgtgaccg tattatgggg cgtatcgcct 3580501 gtataggcgg caatgccggc tttttcatcg gaatacgtct gccacgtgcg gaagatatgg 3580561 tcagcagctt cggcgacatg acccggttcg tctccttgga gcctgagcac agacatcggc 3580621 cacttcacta agcccagcga cacgccggga taatcattta attcataaac gtcttccgct 3580681 tctgcacgtg ccattggaaa atcatgcgcg ccgccttgga aatgatcatg gcttaggatg 3580741 ctgccgccga caatcggcag atccgcgttt gaaccgataa aataatgcgg atattggcca 3580801 agaaatgaca gcagcctttc aaatgttttt ttgctgatct ccatcggttc atgttcacct 3580861 tttaagacaa tgcagtgctc cggataatag acatatggcg agaattgcag gaaccattgt 3580921 tcgtcctcaa ggatgaccgg aatgattctg tgattttgcc gggctggatg attcacgctt 3580981 ccctcgaagc cgacattttc tttacacagc aaacacatcg gataatttgt ctgttcctgc 3581041 tcttttgcag ccgcaatcgc tttcgggtcc ttttcaggct ttgataggtt aatggtcatt 3581101 tccagctcgc catattcggt cggcaccgtc caatgaacat ttttggcgat tctgtcagtc 3581161 cgtatataat agacatcctc tgaatattga tagaattcct ttgtcgcctg ttttgggccg 3581221 tataatgctt ttgtctcttc aaatttgcga atgacctcgg acggggcagg cacaaaacag 3581281 cccatcagct ttgcgctgag caggtcacgg tacgtatctg tatccgcttc cattcggccg 3581341 gtttcggcag cccatttata gatgggagct agcaagtccg gcaggctttg tgactgcttg 3581401 atgctggtgc tggagttcgg ctcgggatgt gtgatgccca gcgcttcata aagacggttt 3581461 ctcgtatatt cccgatccca gatcgaaatc aattttcgtt ccaggccata ctcaagcagc 3581521 tgttccagat gttcaataat actcatatgt cactccccct ttagttctct cgctccctct 3581581 ccgatatccg cgacataaaa gtccgctcgg agccctgttt tttcttgata tctgtctcca 3581641 accttctgaa taaaatcatc aacgaactca tcttttacaa tgctgatggt gcagccgcca 3581701 aagcctgctc ccgtcattct tgatccaatt acaccttcgt gatcccatgc cgcaaacaca 3581761 agctcatcaa gttcagggca tgttacttca tagtcatcct tcaatgaaag gtgggattcc 3581821 ttcattaact gcccgatttc atctatattg ttctctttga acatatgggc cgtcttaata 3581881 gcacgatgat tttcgtatac agcgtgcttt gcccggcgtc tgttcgtttc attttggatc 3581941 aggctggaat gcgcatcgaa atcagaaggc ttgatgtcgc ccagtgcggc aatatcgagg 3582001 ccttttttca gatcaagcaa tgcatcattg cattcttggc gtctcgtatt atagctggag 3582061 tcagccaatg tccttttttt gttcgtgttc gcgatgacca gcgcgaggcc tgagacattg 3582121 agtttgctat attcatagtc aagcgtgtca cagttcagca gcatcgcatg atgttttttc 3582181 cccattccaa ttgcaaattg gtccataatt ccgcaattga cgccgataaa atggttttcc 3582241 gcatgctgcg ccattttcac aagctcaagc gcatctactt caggatgaaa ataactttgg 3582301 agcacgaccc ccatcagcag ttcaatagaa gcggaagacg acagtcccgc cccgtttgga 3582361 atattccctg aaaatacaat gtcaaagcca tggggaactg catatcccct ctgttgaaat 3582421 tcataaatca cgccttttgg gtagttcgcc cagtcgtctt ctttttgata gcgaatgtcg 3582481 tcaaggctgc attccttgat gcctgcgttt ctaaagttat ctgaatacat ccggacaagc 3582541 ccgtcgtttc tttctgcaac agcagcatat gtacccattg tcagcgcgca cggaaagaca 3582601 tgcccgccgt tatagtctgt atgttctcca atcagattca ctcttccagg tgcgaaaaaa 3582661 aaccgtaacc cctctttttc tccgaataca cttgcaaata tcccctttag ctcttcccgc 3582721 atgtgcaatc acctttctgg tttttatttt ttattcccct tatttcttca tagaaaacgg 3582781 cagatcatat gctgcagtcc tctcataccc cttcttcttt tgttttttta aagacgagcc 3582841 atttgctcgc aacatagttg acgacaacaa tgaccgcgtt gtcgagtatt ttggccaagg 3582901 tttcatttgt attgaactgg ccgacaagaa tgatcatcat gcctaaatct atgccgagag 3582961 acaggacccg aacgctgaaa aaagcagtga gctctttcag caggctctgc agatcatgtg 3583021 ttttttgctg aaacacatat aatttatttg ttatgtaagc aaacagcacg gacaaaatcc 3583081 aagcggcaac agtggcggct ttgtaatcca cattcatgat ctctaccaat atataaaagc 3583141 tggcgatatt cacaatggtt gtgaaaaccc ccataatgat atacataatt atttctctat 3583201 acttcactga tgttcctcgc tttctgaaaa acttttcaaa attcttggcc tctcgtgctc 3583261 tctgtctaaa gtaaaaaata ccgagagtgc gtctaaaaag ctgcggaagg tggctggctg 3583321 gcccaataca tatgattgtt tgatgattcc gtcgaggact gcacatatta ttttagccgt 3583381 atattcagga tcaatacagg cgtcaatcag ctttctctcc ttcagccact taatatataa 3583441 cacattttct tccacccaca attcgtacag ccggacatag gccttgcatt tctttaagac 3583501 tttatatgtc ggcatgttca tggcaaacga ggtgatgtcc cacgacggct tatttatgta 3583561 ataggaataa agcagttctg cagcgtgttt tgcagcctcg tccaatgtca gcgatttcac 3583621 tgactcccgc tccatttgat caagataccc tataatgatc ttttttttca tctgacgttt 3583681 ttcgagaagg tacagcagaa aatcgtcctt gctgacaaaa tgaacataaa atgctccttt 3583741 gctgtacccg gcggctctgc tgatatcttc tacagaaacc ggatcatacg ctcggtcaat 3583801 caacaaattc acgccagcgt ctataaaact ttcaaatgtt gcttctcttt taatttgaaa 3583861 tttgtttttt ttcatatttt tctcctggcg gtaatgatta cccttatctt acaccggatc 3583921 aatctttagc ggtatttatt tctttaaacg gttatgctat tcggtttccc aggggtcatt 3583981 tttaataggc taaatgattt attttcattt acatactatc cagtcagtat ttaattgttt 3584041 attattataa ataaggtcca ttggttatat tagtcatttt tttagggaat aggtaggtgg 3584101 tttttccttc agtttgtgaa caccgagcaa ctatgtgtga aatttgttgt actcgcctcc 3584161 atcatcgcgc tggcttgtct tttattgccc gcatgttgca ggaaaacatt ttatacaatt 3584221 ggaggttact atgaaaactc atgttaaaaa agatttggac aaaggttggc atatgttaat 3584281 tcaagaagct agatccattg gattaggcat tcatgatgtg aggcagtttt tagaatctga 3584341 gacagcatca agaaagaaaa accacaaaaa aaccgtccgg caagactagt ccgaacaggc 3584401 ggatctattt acctctggct tttctatcac ctgatctgag ttttcaccat atcctctatt 3584461 caaaagcaaa tcgctgcgct gagcttgagg acaaacggtg tgtcagctaa ctacgacaga 3584521 cagccggtga tgcgatcacc tcttggcaca tgcattgtca taaagaggtg atgcgaacat 3584581 gataaccgtg ctctggtaaa cagcagcttt gctgagaaca agctgcattc ggtgaggttt 3584641 tgaaagcaaa ctcgtttata cacggccgag cttgaaaacc ttcgcctgtc tttagaccac 3584701 tgtgttcacc tcttcacgac ttccttcttt tttcatcctc cagctattgt acaacgcata 3584761 aatcggactt tcagtacata cctattggtg tacctttttg cttacgttta gcgaataaaa 3584821 ggaggaaagc catgtacaaa gctgattata aacagattgc tgcaacgccg tcttttcaag 3584881 cttttttaaa gcagaaacgc gcttttattg ttccttctgc gattttcttt tttgtttttt 3584941 atttttcact ccctgttttg acatcttatt tcaccttttt gaatgcaccg gccattggag 3585001 ctgtttcatg ggcttggctg ttcgccatcg cccaattcgc tatgacctgg atactgagta 3585061 ctgtgtattc ccggagagcc gcccatttcg ataagtatgt aagcgcttta aaagaggatc 3585121 tgaagggtga acagacatga atatgactgc ttttttatta tttttggcga ttgttggcct 3585181 gacgcttatt atcacgtatt ttgccgcgaa gcggacgaaa acgacgagtg agttttatac 3585241 ggcgggcggc gggctcaccg gcgttcagaa tggactggca attgccggtg actacatgtc 3585301 tgccgcctcg tttctcggga ttgccggaat gattgcgtta tatggatttg atggcttctt 3585361 ttacagcatc ggttttctgg tggcttatct cgttgtcttg tacatcgtgg cggagccgct 3585421 tcggaatctt ggaaagtaca cgatggcaga catgattgcc gctcgcttta aagaaaagaa 3585481 aatccgcggt gtcgcggctc tcaataccat tgccatctct actttttata tgatcgccca 3585541 gctcgtgggg gcgggcgcgc tgatcaaact gcttctaggg ctggattata ccgcggctgt 3585601 cctcatcgtc ggagtgctga tgaccattta tgtcgtgttt ggcggcatga tcgcgacaag 3585661 ctgggttcaa attattaaag ctgttttgct gatggccggc acactcgtga tttcgattat 3585721 cgtgttttcg aaattcggct ttagccttaa taccatgttt gaacagatga aaacggctac 3585781 tccgcttggc gctgattttt tgaaccccgg aaataaatac aaggtgccgc ttgagacctt 3585841 gtcgttaaac ttggcactcg tgctgggaac cgccgggctt ccgcatatat tgatccggtt 3585901 ttataccgtt aaggatgcca agacggcccg tacatccgtt gtgtcagcga catggattat 3585961 cggtgtgttt tacattatga cggtatttct cggctttggt gccgcggcat ttgtcggttt 3586021 tgacgcgatt acggcggctg atcaagcggg aaatatggcg gctccgcttt tagcaaaagc 3586081 gctcggagga gactttctgt tcgcgtttgt atcagccatc gcctttgcca ccattttggc 3586141 tgtcgtgaca gggttggtgc tgtctgccgc ctcagcattt gcccatgata tttacagcca 3586201 gatcatcaga aagggagaag caactgaaaa agaacaaatg aaagcggcca gatgggcttc 3586261 tgtcgccgtg tcagtgctct cgattctcct tgcgattttt gcacaatcct taaatgtggc 3586321 gttccttgtt gcactcgcgt ttgcggtagc cgccagcgca aaccttccgc tgattgtgtt 3586381 tacagtcttc tggaaacgat tcaatgcctc aggcgcttta tggggcagcc tgacaggcct 3586441 gatcagcgcg cttgtgctgg tatcgatgag ccctagtgtg tgggacccgg ccggaggtgc 3586501 tatttttacc ggtgatccgc tcattccgct atctaatcca ggaattattt ccatcccgct 3586561 cggctttctc ggcgcgtggc tcggaacggt gctgtcgtct gataaaacaa ttgatgaaga 3586621 tacgtttgca gaaattcagg tgaaggcgca tactggcgtc catatggaac aggaataaaa 3586681 aaagctctct ttatcgagag ctttttcctt actttttctt ctgctcgtca gaaatcgctt 3586741 tttcaaatac atccttgccg gcagcacccg gaattacagt gtcaccgata ataaaggttg 3586801 gaacggctgt gatgtcagcc tcttcatagg cgtgcttcaa ggcttggcgc tgcacgtcct 3586861 gatatgttct tgtttccagt gctgatttga atgatgcacc gtctaatccc acttcctcgg 3586921 cgagcttcgt caagatgtca atatcgccga tattttggtc ctcctggaaa aatgcctgaa 3586981 agacacgggt gttgtattca tgtcctttat tgtattcctt cgcaaaatgg aagccttcaa 3587041 acgcgaggtc tgtatacgga tggggcgaga cgtttggaaa attgatctcg actcctaatt 3587101 tctccgccat tggctgaatt gatgtctgcc acatgtactg tttagaagga tcattgaccg 3587161 gatcaagctg aggagatggg cttgggcgca gttcaaacgg catccactcg acttcaacat 3587221 cctttccttt tatcgcttct tcaaaagcgg cttttccaac aaaacaaaat gggcagacgt 3587281 aatctgaata aactttaatg tgtactgtca tgataatctc ctttcatact aaattgattt 3587341 taaactgtaa caattaaagt tacaactgtt ttttaataaa gaagccgatt taggcttctt 3587401 tcagattgat gacaaaatcc taaaaagttt taggattttg tcatcctttc agcgtgattg 3587461 aaaacccttg aagtctagga aagccgagca ttggagcgga gcgaatgctc taattcgtga 3587521 gcaccaacgc acaggcttga caacgaatgc gagggtttgt cgacacgctg aaagaagcct 3587581 gtaaaggctt cttttatgat tccagcaaac gctgggcaat atattctcct tttttgcagc 3587641 cgcctgggca tgcgtataaa gcagaaccga ttgtttgtgt atattcgttt aacgcatcct 3587701 ttgctgaaag agccttcagc atcgggataa actgattgtc gggatttttt tgaaaactga 3587761 taaacaggag acctgcatcc atatagccgg ttttcggatc aagtccttct gtgtaagaga 3587821 aagctcttcg caaaatttgt ttcccagtag atttcgctag actgacgtgt gaattagacg 3587881 gaatttgatt cagcttcacg ggatctgttt cctttttctg cccaaaaggc gcccccgagc 3587941 tttttctgcg gccgaaggta tcctcttggt ccttgaggga agagcggtcc catacctcaa 3588001 ggaacatttt gattttccga aaagccatat aggtgccgcc cgtcatccag tcaggctcac 3588061 cagactgaat ccacacgatc gagttcatca acgtgtcatc cttcgtgctc tggttgcctg 3588121 ttccatcttt aaacccgaag aggttgcgcg gtgtttcacc attttttcca ccgcttaaaa 3588181 agcctttgtt cacaaaacgg acctcacaag tgccgaccgc ttgatttagc aggttacgca 3588241 gcgcgtgaaa cgccacttgc tcgtcgtctg cacacacttg aatgcagatg tccccgcctc 3588301 cctgcttttc atccaggttg tcattgggca tcgctggaag agcggctagg tgcttcggtt 3588361 ttttgctttt cagtccgaag cggtcctttc cgtctttttc aaaaaagcca ggcccgaatc 3588421 cgaatgtgac cgttaagttg gaaggggata aatcagcaga ctcacctgta tcctgcggcg 3588481 gcagatactg atttctctgc tccgctgaca ttttcttgcc agacgtcagc atctgtgtga 3588541 gacttgtcca gtttctaaat aacgtaatga tgtcgctttt gtcttttgct gttacatcca 3588601 gtgcagcaaa atagacatac gtctgatggg cagttgtgat tccggcctga tgctttccgt 3588661 aaaacggaac aatctgctcc tcctcttttt catccttttt cgatggctta gccgcagtct 3588721 gaacaagcgg agcgagaccg ccgagaccgc tggcaccgat cgcaacggct gcccccgcca 3588781 tcgctcccca ttttaaaatg tcccgtctgt gaatttgttc tggctttttc tgttcatcgc 3588841 tcatgatgtt acaaaactcc ttttatagca cattcgcaat cttcgacatg gtttcagaaa 3588901 gagtcgtcag cttagtgctc agctctctga tttgcttttc acttaattta tcataagacg 3588961 tataggactg atcatttgtt ttgtattttg ccattaaaac ttcaaattcg ctgaactccg 3589021 tatccagttt ttccgtcaag tcggagtgat cttttacaag cgcgcttttc actgtttgat 3589081 aaacggcttc ggagccttcc acatttgcca taaggtcaac taaatcaatt cgtgagtagc 3589141 gctcttcttc tcccgtgatt ttcgaaattc cggcttcgtt cagaagctcc atcgcgcctg 3589201 caacaatttg ttcaggtgtt aatttcagtg attgaattga accgtcaagc tcttttacat 3589261 ccttgagaag ctggtcagct gttgcctttt ccccggaaat atcttgatcc ttccaaatgg 3589321 ccttctcaag cttatggaag cctgtccatt tgtctccttc ttcaacatcg ttttctcgtg 3589381 cgtcaatttt cggatcaaga tctccgaggc tttcagcgat cggttcgatt cgctcgtaat 3589441 aaacacgcgc tttcgcatat aacgttttgg acttttcgat atcgccggat ttcacagcac 3589501 ccgtaaatgc ttcagtcgct ttgacaagct ggtcactctg ctctttgaca tagcctttat 3589561 actcatccgc tgcttttgcc agctgatcgc tagccttttt gccgctcttc ttcgcttctg 3589621 tcaggtcttc taaggatgct ttcaatgact cggattctgt cttgattttt cctgcatccg 3589681 gtttgtcttt ttgcgcttct gtgtagattg gctgaagatg cttttcgatt tctgtatatt 3589741 cgaatggata gtcgctgcga atatcgtttt caaaggaaag ccagtagctg tttaactctt 3589801 tccccttctt ttcaatctct ttttggtctc ctttttccac tgagtcattc agcttagaaa 3589861 tgatggtttc cattttattt acggatgcgg tgatttcttt agtgaccccg cttttttcag 3589921 atgaagcttt ttctttggtt gaagatgtgt cattggctcc gcagcctgcg cacagcgcaa 3589981 ggatgcatcc ggctgataca gcgatttttg tgaaattcat tttgtcagtt cctttccgtt 3590041 tgtaaaatgt tttgccgctt ctgaaacaag cgcaatcagt aaaaagagta aaatcaacat 3590101 ttgcggaatc gtgctgtaca cagacggata aattcctagc accgatacag acggcagcca 3590161 gctttctgca tcagacggaa gaatgcccgc cagttgaagg ctgtgaacgc cggttccgag 3590221 aaatttcacg cacatataca ggacaaccgc cattgataga agaaaaaacg gcttcaatgg 3590281 aatgcgcatt ccgagcttga tcatcagaac accgacgatg acgagaacga taagccctgc 3590341 ggcagttccg ccgatcagtt cagtgagcgg gagcttcccg acaagcccga tgaaaaagat 3590401 gaccgtttcg agaccttctc ttacaactgc cagaaatgca atgagcgcaa aggaaagcag 3590461 gcttcgtttt tttagtgcct gtgacttctg gatattgatt ttttctctcc atttatccat 3590521 tgaggcgttt ctgtgcagcc acaccccgac atacaaaagc atgacagcgg acagtacgcc 3590581 ggtaacgccg ccaagcaaga aattgttttc tccgaataca ctggaggaga acagaaccgt 3590641 gacaccgatg ccggctgcta aggaaacagc catgccggcg gacgccccgc cccagatcca 3590701 tgtcgaggaa cgcgtaaccc gcgctttttt tgtcatggtt aatagcgctc cgatgacaag 3590761 gagggcctcc attccttcac gaaccgggat cagcgccgca tcccaccagc tgtagctgct 3590821 tgaagcgatc ggctcgagca attgaatcat ttcgtcaatt tgctttgata ccttttcagg 3590881 atggctgccg atctccgcct tcatcagcgc cagattttcc tccgatgtcg tataggcttc 3590941 tttcgattgg gacacgacat ctccctcaac agcgagccag gatgtaacta aattgtcgat 3591001 tgcggatgac gcttcatcca attgtttttt ttctatgaac tgttttgtgt ctttcaagct 3591061 ttgtatatag gctgttaagg acgcccttga ttgacctgag gatgtctttt tcagcacgac 3591121 agcctgctga taggtttcta aatgagacgc aagctcttca agctgtgttt tgagcttacg 3591181 tgcgtcttga ttgataaaag aaagagaaat catcgcgata ttcgcgtcca tttcactgtg 3591241 agaagaaagg ttttctttct taatagaagg ttcttctttt ttccacttcg ccttgaaggt 3591301 gtcaaacgtt tgttgtgccg aatccatatc cccgtctttt acggatttga tcatttgctt 3591361 gtttaattga attaatgcgg cgatcggatc atcttccgca tgtgccgcag aaccgaaaac 3591421 catcaacaag ctgaatagaa taagtgccag cccccgagcc atcatgttcc tcctataatt 3591481 gaaaatgatt atcattgtat aacataatca tagccagttc ctgtcctttg tcaattaaaa 3591541 tttgaaggtc tgaaaacctt gatggacagc aaaaaagctg tccttttaca gaacagccct 3591601 ttgaaggaaa atgaacgatt atcttcctgt tttatacgtt tgaatttcct cacgaaactt 3591661 gcgtgcagca ctctcaggat cctccgcctg actgatggcg ctgatcatac tgacgccatc 3591721 ggcccccgct tggataacag gtgcggcatt atctattgtg attccgccga tgccgacaat 3591781 tggaatgctg atgccttggc ggcgcactgc ttcgataaga gatacaccct gtaccgctct 3591841 cgtatctttt ttcgtttcag tcggatagat cggcccaagc ccgacataat ccgctccgtc 3591901 ttcttcggct tgcttcacct cagacatcgt atgggcagaa acgccgagaa tcatatcacc 3591961 tatggcagct cttacctctt tcgcatttgc gtcttcctgg ccgatgtgga taccatcagc 3592021 tttcagattc agagccaatt ccacatcatc attgacaatg aacggaacac cagcttcacg 3592081 gcaagctgcc tgcgcttttt cagcaaattt aatccgagcc tctcctgtca gcgcatcccc 3592141 gcctttttca cggaactggt acagggtggc accgcctttt aacgcttttt gtacaactgt 3592201 aacaggatcg gctttcgtat tgtttgaccc cataatgaag tatacagata ataactcttt 3592261 catcatttcc cgagaaatac gagtcatgag acagtcaccc tttctatagt cgcccattct 3592321 tggacgtctt gttcagtaac agttgaaagc ttgttcagca attcaatctg aaagcttcca 3592381 gggcctttgt cagccgtctg ctgtgcggca agctgagcgg cgaccccata cgaagaaatg 3592441 gccgcaatag cagcaaacaa tggattttct tccacagcgc aaaacgcacc gacgacggaa 3592501 gtcagcaggc aaccggcgcc tgtcactttt gtcagcagct tgtggccgtt atgaagggtg 3592561 tatacatgtg acgtgtcggc tatgacatca acttcaccag ttatcgcaat gaccgtgttt 3592621 agcttttgtg ccgcctgctg agccagccgg atgatgtcgc ctccaccttc acccgcatca 3592681 acacctttga tcagccaatc ggtcacgccg acggtatggg caatttccgc cgcatttcct 3592741 ctgattgcag caaggcgcac ctcacgaatg atgtcacgtg ccgattcagt gcggaacggt 3592801 gttgctccgg caccgacagg atcaagaatg acgggaacgc catgttcatt agctgatttt 3592861 cccgcgatga tcatcgcttc gactgactcc ttgctcagtg ttccgatatt taaaacgagt 3592921 gcacccgcaa ttttcgccat atcggcgacc tcttcttttg cgtacgccat aacgggcgat 3592981 gcgccgagcg cgagcaggcc gtttgctgtg aaattcgtta cgacattgtt ggttatgcta 3593041 tgcaccagtg ggctatgccg gcggacagcc gtaagacatt ttgctgctga ttgtgcatcc 3593101 atatttgcat catcctttac tatctttttt cgggtcccat aaatacgatt tcgtatgttc 3593161 gagccaagct ctggcggcaa acgacaagta cctgtccttt ctccaaataa tggcgaggtg 3593221 ccaagggatg accggatcga caagcggaat gactttcact ttttccgggt caaggccgcg 3593281 gcagatccgt tccggcaaaa gcccgatccc aaggttggcg gataccatct cactaataaa 3593341 atcccattgt gatgtttcat aaatgatatg gggccggaac ccagccttga tacattccgt 3593401 cataattcgg ttgtgcagga caaaatcctc tctgaagaaa ataaaaggct cgtccttcaa 3593461 ctcacgcagc tgacattctt tctcatcagc cagccggtgg gaagggtgaa cgacaagcat 3593521 taaggtttct tttacgattg taaacgaatg aaagatatct tcgtttgcgg gaaggaccac 3593581 aacgccgata tcaagagagc cgtccccgac accttcttgg acttttatag aaccgtcttc 3593641 gactagctga aaggtgacat tcggatagtt ttcacggaaa tcgccgagca ctctggggaa 3593701 aaaccccgat ccgatcatcg gcggcagtcc aatccgtacg tgccctttct tgacttccat 3593761 aatatcattt aattctgacg tcaggttttg aaatgattta atgatttcct gcgcctgcac 3593821 atacatgcta tgaccggcat cagtcagttc cacctgcctg ccgtttcggt aaaacagttc 3593881 aattccgagc tcttcttcta aatttttgat catttttgat atcgtcggct gagaaacata 3593941 aagggattgg gaagccttcg taaaactttt taaacgggcg acttccaaga aatatgttaa 3594001 atggcggata tccatgcgct tcaccctttc tatagacaaa aggaatactt cttattctta 3594061 atatatattt tacctataga gagaccttat gtacaataag tatataaggg aggcatcaat 3594121 atgaaaaaac tgttgctaac cgttattcaa atcgctctgt tatttatatt tgctcggctg 3594181 attaattggg tgacagccct tcttcatata aatattcccg gcagtataat agggattgtg 3594241 attcttttca cattattgca ctttaacatt atcaagcttg aatggatcga gcttggtgca 3594301 gcgtggcttc tcggggagct gcttttattt tttatcccgt ctgccgtcgg agtgattgaa 3594361 tacggagaca ttatgtcgaa atttggtgtc agcattctgc ttgttgtcat catcagcacg 3594421 tttgtcgtga tggtgtctac aggaacgctt acacaactca tcgcaaagag aaaggagaaa 3594481 aagcatacgt gttcatcgga attgtaagtt tgtttttaac ggttttggtg tatttaggag 3594541 caaaaaaggt atatcaacgc tttccgcgtg tttatacgtc gccgctattg gtgacgcccg 3594601 ctgtattagt cggtctgctg ctgctggtga atgtcccgta cgagtcctat aatctcggcg 3594661 gcggattgct gaccgatatg ctacagccgg ccaccgtggc attcgcgatc ccgttatata 3594721 aatatttccc tgttttaaag aaatacgcag tggaaattat tttgaatgtg gccgtcggtt 3594781 catgcatcgc gattatttct accgctctta ttgcgaaatg gcttcacctc ggcaccggct 3594841 taattgacag cctcgtccca agatcagtga caacgccgat cgcgatgaac gtatctgaaa 3594901 tgatcggcgg tatgcctgcc gtcacagccg tgtttgtgat tttaaccgct ttgctcggca 3594961 cagtgatcgg cccgatggtc atccgttatt tccgcattga taacgaaatt gcgcggggcg 3595021 tgctgcttgg cacaagcgcg cacggagcgg gaacgtcaaa ggcatttgag ctcagctctg 3595081 tgtccggcac gatttccagc gtgtcgatga tcttagctgc gattatgacg ctttgcgcgg 3595141 cgccgttttt gctttcattt atgtaaaaaa ctgtcctctc gagggcagtt ttttttatgt 3595201 gcttcccctt attgaaaagc tggcgaattc caatataatg tatttgtgga taccaaagga 3595261 ggcaccctga tgcacaactt gcaggtgagg cggcattatg ccgcgttaaa aggattttat 3595321 ttgtttgctt ttctcggtac gggcagcata attcccttac tcagtatgta tttaacgaag 3595381 gaacagcatt taagcggatc acaggtcggc ttgatcatgt cactgggccc gattgtgatg 3595441 attttctttc agccgttttg gggcatgctg agcgactata cgcaaaaaac gaaaggcctg 3595501 ctggcggttt gcacatcaat cacaggcatc attggattag cctatattgc atttgacagt 3595561 ttccctctgt ttattttgat tgcggcctgt tttgcagcct ttcaaagcac gattattcca 3595621 ctttcggaca gcatttcact aaggtacaca caagaaacaa acggcaacta cggcggaatc 3595681 cgcctgtttg gttctctcgg cttcggtgtc gcggtgtttg ccatgggaca ggtgacgaac 3595741 cagctgtacc ccattcacgt gatctttatc tttggctgtg cctttctgtg cattgctgcc 3595801 atattggctt cacaagtgcc cggccagcag aaaacaacaa aggtcaatat ccgcaaagga 3595861 ttccgggagc ttatcagcaa caaaactttc ctcatcttta tgatcatcac ctttacgaca 3595921 tttgctccaa acttagcgaa caatacgtat ttcagtcttt ttctggacaa aagcggcgcg 3595981 tcactttccg ctatcggcat tttatttttc atcggtgtca tttcagaaat tccatttatg 3596041 agattcgccc aaacatttat agataaaatg gggctgctca acgtcattat gctgtcaggc 3596101 ggagtctcat tattcaggtg ggcgctctat ttcacggcgc cttcactatg gatcatttat 3596161 gcgacggtct ttcttcaggg agtggccatc ggtttattta tcccggcggc gcttcaatat 3596221 gtgaaaaaga ttaccccaag acacgttgaa gcgacggcgc tgaccatgta cgccgccatt 3596281 ggcaacgggt tcggcaactg gttctgcaca tttgcaggcg ggtacatttt tgactacgtg 3596341 tcgatcttcg cagtctactt gctttttggc attctgagca tagcaggctt tggcctgaca 3596401 ttatatttaa tgaaggctga aaaaaacaaa catacacttc atcagccggc tgttactttt 3596461 aaaccataat gactataatg aacaaaagaa aggatgtgcg ttatgaacgg gcaagagcga 3596521 aacagcattt cgaaagggtt gcaggttgat attgtattga aagcagatca aaaaacagga 3596581 aaactgacga gagggacagt gaaggatatt ttgacgaaat caaactttca tccgcatggc 3596641 attaaagtcc gtcttgaaga tggccgcatc ggccgcgacc agcagatcgt ttctacataa 3596701 aaaaaagctg cccctgaaca gggcagcttt ttcattattt tttctgcaga aggaccactt 3596761 tcaggtagtt gccttccgga aatgccgaaa tcgttttgaa atcctccggc agcgtaaatt 3596821 cctcaatgat cgtgtagcgt tcatttgttt ctttaaaggc ggcatcaata aagcctttga 3596881 acttcttcat gccaaaggcg ctgctgtttg tagaggcaac aatgacaccc ttgtcagcag 3596941 tgatggcgat cgtttccttc agcaggtttt tataatcctt ggccgcgctg aaggtgcgtt 3597001 tttttgtgcg cgcaaaggaa ggcggatcta gaataatcag atcaaagcgc aaatcctttt 3597061 ttgcagcata tgaaaaatag ttaaaaacgt ccatcacttt aatgtcgtgc gcttcgtaat 3597121 ccagcttgtt cacgctgaat tgctcgatcg ttttggcaag acttcgattt gccacgtcga 3597181 cgcttgttgt tttctccgct ccgccaagcg ccgccgccac ggagaatgca cccgtataag 3597241 aaaacgtatt taaaacggtt ttcccttttg catagcggtc tctgatcgcc ttgcgcacat 3597301 gtctctgatc caaaaagatg cccgtcatgg cgccttcatt cagatccacc gcgtattgaa 3597361 tgccattctc ttggatgatg atcgggaact cgccccttct ccctttcacg aagtcatcat 3597421 cttcaacgta ttgtccagcc gtgtcgaagc gtttcttctc gtaaatcgct ttataatcaa 3597481 gatccatctc atccaatgcg gaaatcagca tgtctttaaa ggtgtaaatt cccttgctgt 3597541 accattgaat cagcaggtag ccgtcataat agtcgatggt gacgccgccg acaccgtcac 3597601 cctcaccgtt gaacaggcgg aaagctgttg tatcttgagc ctcaaatagt ttggcgcgcg 3597661 cttgggccgc ttttgttaat ttgctgagaa aaaatgcttg gtcaatctgt tcatgtttat 3597721 tgcgggtaag cgtccagcca acccctttgt tttgcaggcc gtaatagccc cgcgcgagaa 3597781 actcgccgcc gctctcagac acgatatcaa cgaggtctcc ttctttcatg tgccccgcac 3597841 tccctgcgag agcttctttt tcaataaggg gatagccttt ttttattttg gcagcgtgtg 3597901 ctttttttag ggtgagtagc ttcatatatg tcgtcctctt tccgtttgct ttctcttatg 3597961 gtaccacaaa acgccaagat gtctgcattg acagaaagga aaggtttttc tacgatagac 3598021 aaaaagagtt acgaggagga gcagcatggc aaaacgaatt gaccatacag gcatcatggt 3598081 aagagatatt aacgcgtcca tcacatttta tgaagaggta ctaggcatga aattgaagga 3598141 tcgcatcact cacacgaacg gtgtaatcga gcttgctttt cttggctttg aagacggccc 3598201 ggaaacagaa attgaactga ttcaaggcta cagcagcgag cttcccgctg aaggaaaagt 3598261 gcaccacatt gccctgctga cggatgacat cgcggctgaa tatacaaaag cggaaaaaat 3598321 gaacgcaaaa tttatcgacg aggagatcac aacacttcca aacggatacc gttatttcta 3598381 tatcgaaggc cctgacggtg agtggattga gttctttcag cggtaaaaat aaagaacgta 3598441 cattttgtga tgtacgttct tttttatcta taccaactga tatacgttga ctcatcgcaa 3598501 atcatagctt cccagcccat acgctcaacc aattcatgga tgtttttatc tttggctaaa 3598561 aagacattaa tgaatgagtc atatacactc ataaacacaa aatccatttt ctcatcagtt 3598621 aaaacgagct ctgttgcggc ttcatcaaga accgtccgca agttggcttc agttatgtcc 3598681 aaaacgccgc ggttttccac aatcggttct gcgtaataaa accgattgga tccgttcgca 3598741 cctaatacct ttaccaaact cggaatatga aaatttgaaa tatgatcctc actgggataa 3598801 tagaggtctc catttatgtt ttcatgtaac acctcagcca aatcctctct cgcgaactcg 3598861 tcccttaaag cgcctatcga cgtcattaaa gccagcgcca gctcagcatg tgtttgaaag 3598921 ccgcaagaag acataacctt cttccaggaa acagccttgc ctattcctct tatttcatta 3598981 tcgtttggat aaatatgttc ataatcattt tttctttttg cattctccca tccttcaggc 3599041 atttggataa aaggagaaaa gataagagca gcagatgagt attcaactgg tacttgttgt 3599101 aagattggtg attcgtcatc taaccatata taatctagca tgcgcacctc ctttacatat 3599161 tctaacattc ctttcgtttg aaagagatga tcagccctat gacaggctga tcatctatca 3599221 catcacattt ttatccccag attcaaccgc actctcttcc cgccattttt gatgatccca 3599281 tattctgaaa aacggatagt agatagcaca ggtgatcagc agatttacca gctgcataac 3599341 tgcgcccgac acctttccgc ctgtcgccag gtaacctgat atgagcggcg gcatcgtcca 3599401 tggcaccgcg attccggccg gtcttgccac cagcccggtg ctcatgccga tataagtcgc 3599461 ggtaatcgtg aggagcggtg cgatgataaa tgggacaata aggaggggat tcatgacaat 3599521 cggcatgccg aaaatgatcg gctcgttgat attaaatagc gcagggccga ttcctaatcg 3599581 tccaagctgc ttcatttgtt tgctgcggga gcgcacaagc atcgtcagga caagcgccag 3599641 cgtcgccccg cttccgccga cattgatcca aatttgaaaa aactgagtcg taaaaatact 3599701 cggcagcgcc tcgcctgctt ggaaggcgag acggttggca tccatcgcgc cgtaccaaat 3599761 cggcgccatg attccgccaa tgatggaagc cccgtgaatc ccgcacgacc aaagcagcat 3599821 ctgcacaaat tcagcgatca ggcttccgcc gagactgccg ccaaggatgg aaagcggtgt 3599881 gccaagcagg tctcctacga cattgtgcag actctgaaaa ggtgtcattt caatcagaag 3599941 acgcgccagc catacgagaa gcacaatgat aaagccggga atcagcgcga caaatgattt 3600001 gcttaccgca ggcggcacac cgtctggcat tttgaagacg atattttttt gaataatgta 3600061 ccgatagatt tcggttgaaa acaaggcgat cagcatggcg acaaataagc ccttgctgcc 3600121 gagcagcgtg atcgggattc cgccccctac catgatggac tccgttgagc catgcggtgt 3600181 aaacggcacc tcaaacggtg ttgccagcag aaatgcggca attgaaatcg ctccggcaga 3600241 aagggcatcg acaccatagc tttctgccag ccgataggcg atcccaaaag cggcaatcat 3600301 cgccataata tcaaacgaag cgttaacagg atatccgagc ttatcggccc actcgttccc 3600361 aaacacactc gccatgaaat cagcataccc cggaatcggc aagctcgtta aaatcaagaa 3600421 gacagacccg ataataatca gcggcatggt caggataatt ccgtcacgca aagcgctgag 3600481 atgccgctgc ccggcaattt tcccggcgac aggcattatt ttttcctcca tcacccgagt 3600541 gaatgtgctc atcttaaaaa cccccttttc tcattgcttt gtgaacaacc tccgcaatgt 3600601 tttctttatc ttattttgaa aacgcttaca aattcatttg gaaaatttcc tcttcatgcg 3600661 gaaaaaatct gcattttgct aaacaaccct gcccatgaaa aattttttcc ttcttactat 3600721 taatctctct ttttttctcc gatatatata tcaaacatca tagaaaaagg agatgaatca 3600781 tgaaaaacat gtcttgcaaa cttgttgtat cagtcactct gtttttcagt tttctcacca 3600841 taggccctct cgctcatgcg caaaacagca gcgagaaaga ggttattgtg gtttataaaa 3600901 acaaggccgg aaaggaaacc atcctggaca gtgatgctga tgttgaacag cagtataagc 3600961 atcttcccgc ggtagcggtc acagcagacc aggagacagt aaaagaatta aagcaggatc 3601021 ctgatatttt gtatgtagaa aacaacgtat catttaccgc agcagacagc acggatttca 3601081 aagtgctgtc agacggcact gacacctctg acaactttga gcaatggaac cttgagccca 3601141 ttcaggtgaa acaggcttgg aaggcaggac tgacaggaaa aaatatcaaa attgccgtca 3601201 ttgacagcgg gatctccccc cacgatgacc tgtcgattgc cggcgggtat tcagctgtca 3601261 gttatacctc ttcttacaaa gatgataacg gccacggaac acatgtcgca gggattatcg 3601321 gagccaagca taacggctac ggaattgacg gcatcgcacc ggaagcacaa atatacgcgg 3601381 ttaaagcgct tgatcagaac ggctcggggg atcttcaaag tcttctccaa ggaattgact 3601441 ggtcgatcgc aaacaggatg gacatcgtca atatgagcct tggcacgacg tcagacagca 3601501 aaatccttca tgacgccgtg aacaaagcat atgaacaagg tgttctgctt gttgccgcaa 3601561 gcggtaacga cggaaacggc aagccagtga attatccggc ggcatacagc agtgtcgttg 3601621 cggtttcagc aacaaacgaa aagaatcagc ttgcctcctt ttcaacaact ggagatgaag 3601681 ttgaattttc agcaccgggg acaaacatca caagcactta cttaaaccag tattatgcaa 3601741 cgggaagcgg aacatcccaa gcgacaccgc acgccgctgc catgtttgcc ttgttaaaac 3601801 agcgtgatcc tgccgagaca aacgtccagc ttcgcgagga aatgcggaaa aacatcgttg 3601861 atcttggtac cgcaggccgc gatcagcaat ttggctacgg cttaatccag tataaagcac 3601921 aggcaacaga ttcagcgtac gcggcagcag agcaagcggt gaaaaaagcg gaacaaacaa 3601981 aagcacaaat cgatatcaac aaagcgcgag aactcatcag ccagctgccg aactccgacg 3602041 ccaaaactgc cctgcacaaa agactggata aagtacagtc atacagaaat gtaaaagatg 3602101 cgaaagacaa agtcgcaaag gcagaaaaat ataaaacaca gcaaaccgtt gacacagcac 3602161 aaactgccat caacaagctg ccaaacggaa cagacaaaaa gaaccttcaa aaacgcttag 3602221 accaagtaaa acgatacatc gcgtcaaagc aagcgaaaga caaagttgcg aaagcggaaa 3602281 aaagcaaaaa gaaaacagat gtggacagcg cacaatcagc aattggcaag ctgcctgcaa 3602341 gttcagaaaa aacgtccctg cagaaacgcc ttaacaaagt gaagagcacc aatttgaaga 3602401 cggcacagca atccgtatct gcggctgaaa agaaatcaac tgatgcaaat gcggcaaaag 3602461 cacaatcagc cgtcaatcag cttcaagcag gcaaggacaa aacggcattg caaaaacggt 3602521 tagacaaagt gaagaaaaag gtggcggcgg ctgaagcaaa aaaagtggaa actgcaaagg 3602581 caaaagtgaa gaaagcggaa aaagacaaaa caaagaaatc aaagacatcc gctcagtctg 3602641 cagtgaatca attaaaagca tccaatgaaa aaacaaagct gcaaaaacgg ctgaacgccg 3602701 tcaaaccgaa aaagtaacca aaaaccttta agatttgcat tccaagtctt aaaggttttt 3602761 ttcattctaa gaacaccaca cacaaccttt ttcccatcca ttgtacaggc ttttcatact 3602821 attgctatac agccatgaac agcataaaat gaacgttatt acagttatca ccacatatgg 3602881 cgggattgtg actgggcagg caggcaagac ccaatgatgc aaagggagta ttaatgccta 3602941 aaaaacaggg cattttaact cttcttttcg tgttgggctc ataacggcgc cttggacaac 3603001 cccctattct catgctccgt cgtcgacgcg ggcatttttg tcattttcag ccggtatttc 3603061 tcactttttt cattttgatt gtcaactttt catttgatac gatgaacaag ccgacttttc 3603121 ttcagcaaag gaggttttaa ttgcttgcat aaagagattg caaaagaatt actgctgctc 3603181 gcaggaggaa aaaacaatat tatcagcatc agccattgta cgacccgtct tcgttttgat 3603241 gtaaaggacg agacgaaaat tgatatacat gccattgaga acctgcaagg tgtgcagggc 3603301 acctttttcc gctatgggct tttccagatt atcttcggag caggcgtcgt caacaaaata 3603361 tataaagaag tcgttcatgt atgggagacc gcgccttctg aagagcctgt ccaccagaaa 3603421 aaagccagcc ggaagctgaa ccctgccgca gcttttgcga aaacactgtc cgatattttt 3603481 gtgccgatta ttccggcaat aacagcaagc ggcctgctca tggggctgat cggcatgatt 3603541 aaggtgtttc attggttcgc tgccggcagc ccatggatta aaatgctcga cctcgtgtcc 3603601 agcacagcct ttattttact gccgatttta gtcggcttca gtgctgcacg gcaatttggc 3603661 agcaacccat acctaggggc agtgattgca gggcttttga cgcatcctga tctgctggac 3603721 ccgtctatgc tcggcagcaa aaccccgtct tctttagaca tatgggggct tcatatccca 3603781 atgatgggct atcagggttc catgataccg attcttcttt ccgtttttgt catgagcaaa 3603841 attgagaagc tattaaaatc gattgtgccg aagtcgcttg atgtcgtgat cattcccttt 3603901 attacggtca tggtgacagg gtgcctcgcg ctgattgtga tgaatcccgc cgcgtccatc 3603961 atcggccaga tcatgacaca atcgatcgtc tatatttatg atcacgccgg cattgctgcc 3604021 ggagctcttt tcggcggcat ctactccacc atcgtcctat ctggattgca tcatagcttt 3604081 tatgcaattg aggcaacgct gcttgctaat ccgcatgtcg gtgtcaactt tttagtgccg 3604141 atatggtcga tggcgaatgt ggcccaaggc ggagcggggc ttgcggtatt cctcaaaacg 3604201 aaacaatcaa gcctgaagaa aattgcgctc cccgcttctc tgaccgcgtt tttaggcatt 3604261 gttgagccga ttgtattcgg ggtaaatctc aaattgatcc gtccctttat cggagcagcc 3604321 atcggcggtg ctattggcgg agcatacgtg gttgcggtac aagttgtggc aaattcctac 3604381 ggactgacag gcattccgat gatttcaatc gtgctgccgt ttggcgccgc taattttgtt 3604441 cattatatga tcggtttctt gatcgcagcc gtctctgctt ttatagctac attgtttctc 3604501 gggtttaaag aagagacaga ataactggat ttattcgatt tcattcataa aacgggggat 3604561 gaaaggacaa aaaagctatg aaaattaaaa gaatcttaaa tcataatgct atcgtcgtaa 3604621 aggatcaaaa tgaagagaag attctcttgg gtgcaggaat tgcgtttaac aaaaagaaga 3604681 atgatattgt cgatccgtca aaaatagaaa aaacctttat cagaaaagat acacctgact 3604741 ataagcagtt cgaagagatt ttagaaacat tgcctgaaga ccacattcag atttctgagc 3604801 aaattatctc tcatgccgaa aaagagctga acatcaaaat caacgagcgc attcatgtcg 3604861 ctttttcaga ccatctttct tttgcaattg aacgcctgag caatgggatg gttatcaaaa 3604921 atccgctgct gaatgaaatc aaagtccttt atccaaagga gttccagatc ggcttatggg 3604981 ccagagcact gattaaagat aaactgggga ttcacattcc tgatgatgaa atcggcaata 3605041 tcgccatgca tatccacaca gcaagaaaca atgccggcga tatgacacaa acgcttgata 3605101 ttacaacaat gatccgtgat attatcgaga ttatcgaaat tcaactgtct attaatatcg 3605161 ttgaagatac catctcttat gaaaggctcg tgacccatct ccgctttgcc attcagcata 3605221 tcaaagcagg cgaatccatt tacgagctgg acgcagaaat gattgacatc attaaagaga 3605281 agtttaagga tgccttcctg tgtgccctaa gcatcggcac ctttgtgaag aaggaatacg 3605341 gctttgagtt tcctgaaaaa gaattgtgct acatcgccat gcatattcag cggttctacc 3605401 aacggtcagt cgcacgctga gacaaacaaa aaacgctttt gatcatctca aaagcgtttt 3605461 tttatctgat ttattggttg atcgccggat tcccaatcgt attccacttc gtataggaca 3605521 tgtaatggaa atactcatcg cgatacggat gttttgtatt ggagttccaa ggcttttctc 3605581 cgccgcagaa gtgcacgatt gccgggtttt ctcttgtttc attatattgc ttccgcccta 3605641 acagagtcga tggggttttc agctttaaca tgatataggt ttgagcgttc cagcgcggat 3605701 gaagttcata ccactgatca tacaagatcg cattcagtgc atcttggtca tgcagcacaa 3605761 gaaagtcttc gtctgggtgt tcattgataa agttgatgac tttttctgtg atgttttgct 3605821 ttctccaaga ctcaaaatca ataatcatga tacctgagtt aaaatacttc cctgtatcag 3605881 tgacgttcat ttctttcagg cgttcatgct gccccgcatc ctcaacagcg gctacggtgt 3605941 atggcgcaat gtctaagtcc catagcttag aaatatcctc taggacaagc gcatcacaat 3606001 cgatgtaaat cattcgtttg atgctttcat ccttaattaa gtcgggaatc gaaatgcggt 3606061 aatacgcggc ttttgtaata tggctgctct caaccgcatg ttcatacatg ttggtatcca 3606121 cttctaaaaa ctcaatcggc actccgaatt tcaaagtggt ttcttccagt ctttttttgt 3606181 tatcaggctt aattccgcca tcaatgacgt ataattttac ctctctctcc tgatccatgt 3606241 tagtcaataa agaaacgaac atcccaccta aatgacgagc ataattatca tctgcgcatg 3606301 atacgatatg catgatttca tctttcctca atggtattca tctccctttt tgttgtacaa 3606361 gttacatacc ctttttcaaa aaaataaaca cgttctccga cattttttta aacagaatgt 3606421 gtgatacaac aaaaaaggtg tcattttttg aagatgcgat aaagccaata aagaatgaaa 3606481 aagcttgcga ttgtgatggc ttcagccgag acgatatacc acggccatgg cccgagaaca 3606541 tctaagagag aggaaccgcc cggttttttc gtcaaataca tataattcgc gccaagccag 3606601 cgatcaatca gaaaaataca gacgccgtac acattaacaa gcaggactgt cacccataac 3606661 gagcgctggc ccattctgta ggtgccaatc acagccatca gcagacagga taaaaacaca 3606721 gacccgtgag aaataaaaaa gaggatatat cggatatgcg gaaatgaaaa cataccgagg 3606781 tcaggagtgg caagagcctg aatcgaactg ccgatgccga caaaaaacaa aaacacaaac 3606841 agctttctgc tttttgtcac taacataata gctgacaaat acaccgacag gtcactaagc 3606901 tggagaggca atgaagtgcg caccgaccac ctgtccgtgg cgaccatcca tatttgatag 3606961 ccgatttgcg aaccaagcaa aagaaacaca aacagagaac gcaaaaaccg gctggccctc 3607021 ggctgcttga cctcatcttg gaacaaaaac aacagaatgg ccaaaaggga gataatcgct 3607081 aacgtcacta catgctctgt cgaaaacaga tgaaacggat catgcttata gtcggattga 3607141 acatattttt gcaaaactgc acccccgttt tcgggttttt gtttattttg gcgttgtttg 3607201 ggcttttttt attcaaccga tatatgggct tgaagttcac accagactct gttaaaattc 3607261 gtttcatagc taatgattct gataatttaa ggcaggccta aaaaatggaa cgttcacatc 3607321 aacatcagca gcttcggaag gaagaacacg atacactttc taagctcaaa caaatgcccg 3607381 tcgagtcact caacctggaa gccatttcga tcgctacgaa tctgtatcgg tctgcacaaa 3607441 ggctccgtgt caaaatggag actgaggttc tttctaccta taacctttct tggaccgctt 3607501 tctccattct ttatgatcta tgggtatggg gagcgctcga aacgagaaaa atcgctgagc 3607561 tgtcagggat atctacagct acagcaagca acgtgatcaa aacgctcgaa aaaaagagtt 3607621 tttgccgtaa aagcatcgac acaagagatc ggcgactcgt gtttgtctca atcaccgatt 3607681 ccggcaaaca agcgatcgaa gaactctacc cggagtttca caaaggggaa acagagctca 3607741 ttgcgggaat gacgaaggac gaacagaaaa tattgacagg gctgcttaga aaggtagctg 3607801 acaatcttca tacaacataa gctttgacgg gaatccagta gcggtttgtc tccctgtttc 3607861 agagagccgg cggtaggtgc gagccggcgc acaggcaaac gtgaattacc tccccaagct 3607921 ttctttgtga accttagtag caaagaacgg gaaaccgtta ttcgaatgag cggaagacaa 3607981 tgtcttcaac cagggtggta ccgcgtgcat tgagccacgt cccttattgg gatgggctct 3608041 tttttgtgtt tgtaaaaaag gaggaaaaat gatgagaaca tttgagcagc tcacagcgtc 3608101 acaacaaaaa gaggtagaaa gacagcttca gctatacatg acaggcgccc acgaagtcat 3608161 accgccggag gaattaaagg caaagctcgt gaaatcaatt tccacgggca cgccgcttaa 3608221 aattaagctc ggattagatc cgtctgcacc ggatgtacat ttgggccata cggttgtgtt 3608281 aaataagctt cgccaatttc aagaaaacgg ccacattgtc cagctgttaa ttggggattt 3608341 cacaggaaaa attggtgatc cgaccggaaa atcggcagcc agaaagcaac tgactgatga 3608401 agaagttcag cacaatgcca aaacctactt tgagcaattc ggaaaagtgc ttgatccaga 3608461 aaaagtcgag cttcactata actcaaaatg gctgaaaaca ttgaatctag aagatgtcat 3608521 tgaattagca gggaaaataa cggtagcccg cctgatggag cgcgacgact ttgaagaacg 3608581 catcgccatg caaaaaccaa tctcactgca tgaattcttt tacccattga tgcagggcta 3608641 tgattctgtc gttctcgaaa gtgatattga attaggcgga acggatcagc atttcaatgt 3608701 cctcatggga cggcatttcc aagaacgata caacaaagaa aaacaagtcg tcatccttat 3608761 gccgctcttg gaaggcttgg atggcgtcga gaaaatgtcg aagtcgaaac acaactacat 3608821 tggcattaac gaacatccaa acgacatgta cggaaaaacg atgtcactgc ccgacagcct 3608881 gatgaaaaag tacatccact tggcgacaga cttagagctt gaagagaaaa aacagctcgt 3608941 aaaagactta gaaaccggcg ccgttcatcc gcgtgatgcc aaaatgcttt tagccagaac 3609001 aatcgtccga atgtatcacg gagagaaagc agcagaagct gccgaacact cgtttaaaac 3609061 agtctttcag gaaaacagcc tgccggaaga tataccggcc gtaaactgga aaggcgaaaa 3609121 aacgatagcg atgattgatc tgctcgtcaa gctaaagctc ctctcttcga agagcgaggc 3609181 gcgccgcatg attcaaaacg gaggtgtacg catcgacgga gagaaagtaa cagatgttca 3609241 cgccaaagca gagataagag agaatatgat catccaagtc ggcaaacgca agtttttaaa 3609301 gctccaataa tctgatattc cgaaacgctt atgacccttc attcataagc gtttttttgc 3609361 aggtataaag cactgtcttt tcaaaaacgc tctccatctt gcaggaaact cctttagcat 3609421 cccgaaatat tccccaacca tacatttagg ggaggtttat ttttgatgaa aaagcttttg 3609481 actgtcatga cgatggctgt tttaactgcc ggcacactgc tcttgccggc acagagtgtc 3609541 acccctgccg cgcacgctgt acaaatatca aatagcgagc gcgagcttcc attcaaagca 3609601 aaacatgcgt actctaccat ttctcagcta agtgaagcaa tcggccccag aatagccgga 3609661 actgcagctg aaaaaaagag tgccctattg atcgcctcat caatgagaaa attaaagctt 3609721 gatgtgaagg ttcaacgatt caacattcct gaccggcttg agggtacact gtcttcagca 3609781 ggacgcgata ttcttctcca agcggcgtcg ggctcagctc cgactgagga acaagggctg 3609841 acggccccgc tttacaatgc gggattgggc tatcaaaagg actttaccgc tgacgccaag 3609901 ggcaaaatcg ccttgatttc cagaggagac ctgacttatt acgagaaagc caaaaatgcc 3609961 gaagccgccg gagcgaaagc tgtcatcatt tataacaaca aagaaagcct cgtgcctatg 3610021 acgccaaacc tgtcgggaaa taaagtcggc attccggtcg tcggcattaa gaaagaagac 3610081 ggcgaagcac ttacccagca aaaagaagcc accttaaaac taaaagcatt cacaaaccaa 3610141 acctcccaga atatcatcgg aatcaaaaaa ccaaagaaca tcaaacatcc agacattgtg 3610201 tacgtgaccg cccattacga cagtgttcct ttttcgcccg gagcaaatga caacggctca 3610261 ggtacctctg ttatgctgga gatggcgcgt gtcttaaaaa gcgttccatc tgataaagaa 3610321 atccgcttta tcgctttcgg cgccgaagag ctcggcctgc tcggctcctc tcactatgta 3610381 gatcatctat cggaaaaaga gctgaaacga agcgaagtga acttcaactt agatatggta 3610441 ggcacaagct gggaaaaagc gtctgagctg tatgtcaaca cattggatgg ccaatctaac 3610501 tatgtttggg aatccagccg tacggctgct gaaaaaattg ggtttgacag cctgtctctg 3610561 acacagggag gatcatctga tcatgtgcca ttccacgaag ccggcattga ttccgctaac 3610621 tttatttggg gagacccgga aacagaagaa gttgagccgt ggtatcatac ccctgaagac 3610681 tcgatcgaac atatcagcaa agaacgcctc cagcaagcag gcgatcttgt gacagccgct 3610741 gtctatgagg ctgtgaaaaa agagaagaaa ccgaaaacca ttaagaaaca aatgaaggcg 3610801 aaagcatctg acatttttga agatatcaaa taaaaaaaga cggcacttgg gtgccgtctt 3610861 ttttaatcca cttctttctt aatccccagc attttctcat ctaggtaatg ggcaatctcc 3610921 gcggcttctt tcagctcatc tgttaattgc ttaggaacgt cattgttcaa tttataataa 3610981 attttatgtt caaggctcgc ccagaaatcc atcgcgattg tccggatttg aatttctgct 3611041 ttgacgtatt ccacacggtt cgttaaattc acaggcatct caatgattaa atgcaggctt 3611101 cgatagccat tcggtttggg tgtctggata taatccttta cctttacgat tctcaaatct 3611161 tcatgctgct tcaacacatt cacgacatta taaatgtcag aaataaagga acagatgatg 3611221 cgcacgccgg caatgtcgtg aatatgctcc ttcatttcct tcgtcgtaat ctcacagccc 3611281 tttctcatta acttattcac gatgctttca aagcttttta cacgggattt tgtatgttca 3611341 atcgggttgt gtccgtgaat gaggttatat tcctggctga taattgagaa ctttgtatcg 3611401 agcgcatcta gcgcaaattt ataaactaat aactcatttt tccaatcttc cattactgtt 3611461 tttaaatcgt ccatatgtgt tacagataaa tccatgttcg tcatctcctt taacggaact 3611521 ttatccgctg tccatgtact agacgtccct gtctgctgca aggttctatg aattttttta 3611581 caaaatgcgg tcgattgtaa caaaaaaaga ccgcatgaaa cgagcggtct tttttattat 3611641 cggaaatagc tgatcaataa tccgatcgag agcaggaatc cgaaaaatgt atttgtttgg 3611701 gctgttgatt tcattgcgac aatcatattc atcggcattt cgttctggac gaagcccttc 3611761 actgcctgaa ccggcttagg cacgctcaaa aagacgacaa acagccatgg gcttgcggca 3611821 ccggtaataa ccaagccgac aacccagata taagcgacgg caaacgacgc agctaacaga 3611881 gtaacagctc ccttatgccc catcaaaatc gccaatgttt tgcgtccgcc ttttttgtcc 3611941 tcttcaatat cacgaatgtt gttcgacagg ttaatcgcgc cgacaagaat cgcaatcggg 3612001 atggaaatca aaatgctctg catattgatc ttatctgtct gaatgaaaaa cgaaatcagc 3612061 acaaacaccg aacccatgca aatgcctgag aataattcac cgaacggcgt gtacgcaatc 3612121 ggcagcggcc cgcctgtata caggtagccg atcgccatgc cgacaaggcc gatcagcgca 3612181 agccaccagc tgctgctggc acaaatatag acaccgagca aaatggcaat cccgtatgag 3612241 gcaagagcta attgcaaaat cgttttaggc ttcattccgt ggcgtacaat ggcccctccg 3612301 attccgactg attctgctgt atctaatccg cgtttaaaat catagtattc attaaataag 3612361 ttcgtcgcga tctggatcca taggcaagaa aacagcatag ccaaaaacag cagcagatca 3612421 accttcacat aaaacatcgc caaaacggtt ccgagcagca caggcacaaa cgatgcggtt 3612481 aacgtatgag gacgggttaa ctgccaaagg atctgcccca tgctttcttt ttgcggcgct 3612541 gtctgaccct cacccttatt tgtttggttc atcttcctct tcctttctat taaaaggctt 3612601 actttttttc agccggcagc ttaataaaaa actccttttg cttccttatc tatcataatg 3612661 acttctccct tatttcacaa gataccgcaa gaaggcgttt tctttcttat tatacgcttc 3612721 tcgccctgat ttcattaggt ttctgctttc acttgaacga acaggtacag aaaaattttt 3612781 ttaagtacat tacacttttt aaaagttaaa aagatctttt gactccaggt atcttttcct 3612841 ttattatgaa tcagctcgaa acattccatt cttgcccttg caggtataaa gattcatttt 3612901 caaaaacata cgccgatata ttaatttgag ggagattagg gaaaaaatga aactttttga 3612961 gcatctgatc gtcaaataat catgtgattg tcgaaaaaac gggaagggaa tttttgatat 3613021 gctgcaatta atgaaacagc tgtatgaaaa acccgctgtc aagtggacat gtcatacagg 3613081 cttttatttg atgatactgc ttgttttgtt ttttatgtat ggttttcaca ccgcgaatac 3613141 cggttcatat atttataacg atttctaatt ggagagagaa taactatgaa acttttacat 3613201 gctattcaaa cacatgcgga aacttatccg caaaccgatg ccttccgctc tcaaggccag 3613261 tcgctcacgt atcaggaatt atgggagcag tctgaccgcg cggctgccgc gatccaaaaa 3613321 cgcatttctg gggaaaagaa atctcctatc cttgtgtacg gccacatgga gccgcacatg 3613381 atcgtttcct tcttgggaag tgtcaaagcg ggacatcctt atattccggt tgacctgtct 3613441 attccgtccg aacggattgc gaaaattatc gaaagctctg gagcagaatt gctgatccat 3613501 gcagcaggac tctcaattga tgcagtcggc cagcagattc agacagtttc tgcggaagaa 3613561 ctgctggaaa acgaaggcgg ctctgtcagc caagatcaat gggtcaaaga acacgaaacg 3613621 ttttatatca tttacacttc cgggagcaca ggaaatccga aaggcgtgca gatttccgct 3613681 gcgaaccttc aaagcttcac agactggatt tgtgcagact ttccagtcag cggaggaaaa 3613741 atatttttaa accaagcgcc gttctcattt gatttgtctg tcatggacct atatccgtgc 3613801 cttcaatcag gcgggacttt acattgcgtg acaaaggatg ctgtgaataa gccgaaagtc 3613861 ttatttgaag agctgaagaa gtccgggctg aatgtgtgga catcaacacc ttcctttgtg 3613921 caaatgtgcc tgatggatcc gggtttttca caggatctgc tgcctcatgc ggacacattt 3613981 atgttttgcg gagaggttct tccggtttct gtggccaaag cgctgcttga gcgttttccg 3614041 aaagcgaaga tttttaatac gtacggcccg actgaagcga cagtggctgt cacatcggtt 3614101 gaaattacga atgacgtcat cagccgcagc gaatcgcttc cagtgggctt cgccaaacca 3614161 gatatgaaca ttttcattat ggatgaagag ggacagccgc ttcctgaggg agaaaaagga 3614221 gaaatcgtca ttgcagggcc gagtgtaagc cgaggctacc ttggtgagcc agagctgacg 3614281 gaaaaagcgt ttttctctca tgaaggccag tgggcatacc gaactggcga tgccggcttt 3614341 attcaagacg gtcagatttt ctgccaagga cgtttggatt ttcagattaa acttcacggc 3614401 tatcgaatgg agctggagga aatcgagttc catgtcagac agtcacagta cgttcgttct 3614461 gctgtcgtga ttccttatca gccaaacgga acagttgagt atctgatcgc tgctattgtg 3614521 cctgaggagc atgagttcga gaaggaattc cagctgacaa gcgctattaa aaaagagctt 3614581 gccgcttctc ttccggcata tatgatcccg agaaaattta tctatcagga tcacattcaa 3614641 atgacggcta acggcaaaat tgaccgaaaa cgcattggcg aagaggttct tgtatgacgc 3614701 cttacagctc gtttttattc tttatactgc ttggcattct tcttctgccg acgatcattc 3614761 tcggcttaaa cggaaaaaga tttcaagcat acaacatgtt catatctatc attatattgg 3614821 ctttaatttt ttcgcacgac ttacacgggg tcatcgcgct gtgcctgttt acaatatggc 3614881 aggtgctcct gatcagcggc tatctggcat accggcagaa agcgaacagc ggctttgtct 3614941 tttgcggagc tgttatcgcg tctattctgc ctttatttct gtcaaaaata tggccgtttc 3615001 tttcacaccc gcagccgcat catccgccgc ataacctgat cagcttttta gggatttcat 3615061 atttaacctt taaaggcgtt cagctgatta tggaagcaag agacggactg ctgaaagaac 3615121 agctgccatt gcaccgtctg ctgtatttca tcctgttttt cccgacgatt tcctccggcc 3615181 cgatcgacag ataccgccgg ttcgtcaagg atgaacagaa ggcttggacg aaagaagaat 3615241 acgccgacct gctgtatacg ggaatccata aaatcttcat cggtttcctg tataaattta 3615301 ttatcggcta cgcgatcaat acgtacttca tcatgaatct tcccgcaatc acgcacaata 3615361 agattcttgg gaacctgctg tacatgtacg gctacagcat gtatttattc tttgatttcg 3615421 ccggctacac gatgtttgcc gtcggggtca gctacattat gggcattaaa tcaccagaaa 3615481 actttaataa accgtttatc agtaaaaata ttaaagattt ctggaatcgc tggcatatgt 3615541 ctctgtcatt ttggttcaga gattatgtgt ttatgagatt cgtattttgg atgactaaga 3615601 aaaagtggat caaaaaccgt atggccgtct caaacatcgg gtatttcctg ctgtttatgc 3615661 tgatgggggt ttggcacggg ctcgcgccgc aatatatcat ttacggcctc tatcacgccg 3615721 ttctgatgac gtgttacaac tttttcgaga agtggaataa gaaatataaa tggctgccgt 3615781 ccaaccgctg gacaaccatt ctcgctattg tgatcacatt ccatttcgtt tgcttcgggt 3615841 tttatatttt ctcaggaaaa ccatttcatc accaccatta aaggagatta gaaagctatg 3615901 gattttaaac aagaggtatt agacgtttta gcagaggttt gccaggatga catcgtaaag 3615961 gaaaatcctg atattgaaat ttttgaagaa ggtttgcttg attcttttgg aacagtagaa 3616021 ttgctgcttg cgattgaaaa ccgttttgat attttagtgc cgatcactga atttgaccgg 3616081 gacgtttgga atacacctaa caacattgta aatcagctgt ctgagttgaa ataatgaaaa 3616141 agcgtttttt cggtccaatt attttggcgt ttattctatt cgcaggcgcc atcgcaattc 3616201 catcttcatg gctgacaggc ttcatcaccg ataagcgtgt gaaagagtca gcaacagcct 3616261 tgaatccgag tatgtttcaa gggctatatt tacaagatca gatgctcaaa gatccgacat 3616321 atcttccgat ttacgggtct tctgagcttt ctcggctgga cgagttccac ccatctaatt 3616381 attttcaggt aaacaatgag ggattcacgc cataccttgt cggcaaaggc ggatcccagt 3616441 cattgattca ttctttaaac ttcgctgccc acatggatca gctgaagggc aaaaaaatcg 3616501 tattcatcgt gtctccgcaa tggtttatta agcgcgggtc tgatgaacag catttcgcgc 3616561 cgaactattc tgcgctgcaa gggcttgatt tggcatttaa cgatcagatc gatcctgaaa 3616621 ttaaaaagaa aatgatgaaa cgcatgcttc gctttaaggc tgtgcaaaac gatgccattc 3616681 tttctgagct gtacaaagca atggtaaacg gtcagacgtg gaaagtgaac gcgctgaagc 3616741 cggcggcgaa agtgtattac agcatgctgg aaaagaaaga tctgtattat tcaacgacag 3616801 aatcatccgg gccaaagcgc tatatctcgc agtcagtaaa ggataagtca tggtctgaat 3616861 tgaataaact agcggatcaa tcgggcaaac gccactccgg ttctaacgat tttcacatcg 3616921 acaaccctgt ctataaaaag ctgaagccga aagtgcctaa gctgaaaggg aaaaacaaag 3616981 gaagatcgta tgcggtgtca ccggaatatg gcgactttga aatgatgctc gatatcctga 3617041 aggatgcggg cgcagagcct atgtttgtca ccattcctgt taacgggaaa tggtacgatt 3617101 acacgggctt cccgaaaaaa ggacgcactg actattacaa aaaggtaaat aaacaaatca 3617161 gagcgaaggg cttccaggtt gctgatttct cagggcatga atatgacccg tatttcatga 3617221 aagacaccat tcacatcggc tggaaaggct gggtgtatgt cgataaagca attgacgaat 3617281 tttataaaac cggaaaagtc acttcatcct gagcatctca taggacgcgg ctgcatattt 3617341 cctgctaaga tttgtaatag taaaggaatc acagccaact taattaagag gtgttacatc 3617401 caatgaagat gacaaataat acggttttaa tcacaggggg ttctgctggc atcgggcttg 3617461 aactggccaa gcgcctgctg gaacttggca atgaagttat catttgcgga cgcagcgaag 3617521 cacgtcttgc agaagcgaag cagcagctcc caaacatcca tacaaagcaa tgtgatgttg 3617581 cagaccgttc gcagcgggaa gcattgtatg aatgggcttt aaaggaatat ccgaacttga 3617641 atgttctcgt caacaacgcc ggcattcaaa aggaaattga ctttaaaaaa gggacagagg 3617701 agctttttgt ggacggtgat gaaattgaac ttaatttcca agcgcctgtc catttatccg 3617761 cccttttcac acctcatttg atgaagcagc ccgaggcggc aatcgttcag gtcacatccg 3617821 ggcttgcgtt taacccgtta gctgtttatc cggtgtactg cgcaacaaaa gcggcacttc 3617881 actcgttctc gcttacgctc agacaccagc tccgcgacac gagcgtggaa gtgattgaaa 3617941 tggcaccgcc tatggtggac acgggcttaa accaaaaatc acgcgataaa caaggcctga 3618001 cgtaccgggg catttcatct gaagaatatg ttcaatattt cttggacggc ttgaaggaag 3618061 gcaaacagga gattacaaat gaacgtgttg aaggtcttcg ggatgccact cgcgccgatt 3618121 atgacaggtt attcgagcaa atgaacacgc aggagaatta atttctcctg cttttttcat 3618181 atgaatttct tacaaatttg agcaaaccta ttgcgattat ttgttgaagg tatacaatag 3618241 aatataatta ttttcaaata agtttgataa tataaacaat ttaacagcag ggagattgac 3618301 catgactaaa caaacaattc gcgttgaatt gacatcaaca aaaaaaccga aaccagaccc 3618361 aaatcagctt tcgttcggaa gagtgtttac agaccacatg tttgtaatgg actatgccgc 3618421 agataaaggt tggtacgatc caagaatcat tccttatcaa cccttatcaa tggatccggc 3618481 tgcaatggtc tatcactacg gccaaaccgt gtttgaaggg ttaaaggctt acgtgtcaga 3618541 ggatgaccat gttctgcttt tcagaccgga aaaaaatatg gaacgcctga atcaatcaaa 3618601 cgaccgcctc tgcatcccgc aaattgatga agaacaggtt cttgaaggct taaagcagct 3618661 tgtcgcaatt gataaagact ggattccaaa tgcggagggc acgtcccttt acatccgtcc 3618721 gttcatcatc gcaaccgagc ctttccttgg tgttgcggca tctcatacgt ataagctctt 3618781 gatcattctt tctccggtcg gctcttatta caaagaaggc attaagccgg tcaaaatcgc 3618841 tgttgaaagt gaatttgtcc gtgcggtaaa aggcggaaca ggaaatgcca aaaccgcagg 3618901 aaactatgct tcaagcttaa aagcgcagca ggtagccgaa gagaaaggat tttctcaagt 3618961 actctggctg gacggcattg agaagaaata catcgaagaa gtcggaagca tgaacatctt 3619021 cttcaaaatc aacggtgaaa tcgtaacacc gatgctgaac gggagcatcc tggaaggcat 3619081 tacgcgcaat tcagtcatcg ccttgcttaa gcattggggc cttcaagttt cagaacgaaa 3619141 aattgcgatc gatgaggtca tccaagccca taaagacggc atcctggaag aagccttcgg 3619201 aacaggtaca gcagctgtta tttccccagt cggcgagctg atctggcagg atgaaacact 3619261 ttcgatcaac aacggtgaaa caggagaaat cgcaaaaaaa ctatatgaca cgattacagg 3619321 cattcaaaaa ggcgctgtcg cagacgaatt cggatggacg accgaagtcg cagcgctgac 3619381 tgaaagcaag taagaaaaaa gccggcccat tacaggccgg ctttttttac gcttcaattt 3619441 tgttgaaaaa ctgcggcaga tacgctttgt gcgcctctag catttcgtct aaaatctgtt 3619501 tggccacagt atcggacggg acaagcgggt taatcgtcat ggcaaggagc gcagtttgat 3619561 agtcacctgt aactgccgct tctgccgcga cacgttcaaa ggatttgatt tgctggacaa 3619621 ggccgcggac agacaccggc aagtcgccga cagcaattgg cttagggccg gttttcgtca 3619681 tcacacagtt cacttcaact gcggaatcgt ctggaatact cgctattgca ccattattga 3619741 tcgtgttcac cggctgaatg tcatgtttat cattataaat ggagctgatt aagttacatg 3619801 ctgcatcact gtagtaagct ccgccccgtt tttccagctg cggcggtttg atcgcaaggt 3619861 ttggatcttt ataaagctcg aacagctctt tttcgacctt ctgtacgact tcagcgcggg 3619921 tgccctccgt ttgtgatgct tccagttcgt gctccagcat ctcttttgtt ttaaaatagt 3619981 aacggtgata gccgcaaggg atgacattga gcgcttttaa gaaatccggt tcccattcgg 3620041 cgcctgagat atttttcatc gtcatcgcgt ttttcgggtc gcccatcgcc tcgatgactt 3620101 gctccttcac acttacgccg tccaagaaaa catccagccc gaataccata tggttcagtc 3620161 cggcaaattg gacttctacg cggtccacat ctacatcaag cgctttggct acgcccattt 3620221 tgatgccgat tggaacattg caaagaccga cgactttctt caggttggag tagcgaagca 3620281 aggcttctgt taccatgccg gcagggtttg tgaagttaac aagccaagcg ttcgggcaaa 3620341 gctcttctat gtcctttgcg atctcaagga tgaccggaat tgtgcgcaat cctttaaaca 3620401 gacctcccgg gccgtttgtt tcctggccta tcactccgta ttttagcgga atgcgctcat 3620461 cctttgctct tgcctgcaaa agtccgacgc ggaattgggt cgtgacaaag tctgcgtctt 3620521 tcagcgcctt tctccggtcg agcgtaagat gaatgtcaat cgggacgcca gctttttcaa 3620581 ccatccgttt ggcgagtgtg ccgacaatat tcagcttttc ttcgccctcg gggatatcga 3620641 caagccataa ttcacggaca ggcagctcat cataccgttt aatgaacccc tccactagct 3620701 cgggcgtata gcttgaacct ccgccaatcg ttacaatctt caatcctttt gtcatatgct 3620761 tgctcccctt tgctcggtga ttttttcata taactcaatg atctctgcag ccatatcctt 3620821 cactgtcatt gcattcatta aatgatcctg tgcatgaacc atcagaagcg tcatttccgt 3620881 cttttctccg cccgcttcat tttggatcag ctctgtctga taatgatggg cttttgacaa 3620941 ttcttcagca gcgtcttgaa gctttttccg cgcttcttct gcgtcaccgc ttttcgcagc 3621001 ggcaatggcc tccattgcgg agctcctacc gtttcctccg tgaaggatga tttgaaaaat 3621061 gatttgttcc atttcctcat tcacgcgatt cacttccttt ctctacagag ccgcttcttt 3621121 gtcatctgtt gctgcaggcg tttggaccag ctccagatcg ttttcttctt tcagcttctg 3621181 cttatcccac attctgaaga atggatagta gacaacaaag gacacggcaa tattaatggc 3621241 ttgcatgacc gcgcctgaga cttttcctcc tgtcgccaag tagcctgaaa agatcggcgg 3621301 catggtccac ggcactgcga tacccgccgg tttggcgaca aggccggtgc tcattccgat 3621361 gtacgtgagt gtcactgtga caagcggcgt gatgataaac ggaagtaaga gcattgggtt 3621421 catgacgatc ggcattccga atataatcgg ttcgttaata ttgaagatgg ccgggccgac 3621481 cgcaagcttc ccgagctgct tcatttgttt gcttcgggcg cgcaggaaca tcgtgacaac 3621541 cagtgccaat gtggcgccgc ttccgccaat attgacccag atatcgaaaa attgctgggt 3621601 gaaaatctta ggaagctcct caccggcttg gaatgcgatc cggttggcat ccattgcgcc 3621661 gtaccaaatc ggtgccatga cgccgccaac aatgtttgca ccgtgaaggc cgcaggccca 3621721 taaaagcatt ttgacggctt cggcgacaag gcttcctcca aggcttcctc ccagaatgga 3621781 aagcggagtc cccaataaaa cgcttacaat attatgaagg ctttcaaacg gtgtcgcttc 3621841 aacaatcagc cgggctgccc aaattaggaa gatgacggca aagccgggga ttaacgcgac 3621901 aaatgacttg cttaccgccg gcgggacacc gtccggcatt ttgaagacta aattgcgctg 3621961 gataataagg cggtaaatct ctgtggacac cattgcgata atcatggcga caaataagcc 3622021 tttgcttccc atgagcgaaa gcggaatccc gccgccaacc atgatttctt tcgtcgcgcc 3622081 atccggcata aacggcactt gataaggtgt tgctaataaa aatgccgcaa gggaaatggc 3622141 tccggccgac aaggcatcaa caccgtattt ctcggcgagc cggtaggcaa tgccgaacgc 3622201 ggcgacaaga cccataattt caaaggtcgc gtcgactggg taggccagtt tttcagacca 3622261 ggagctgcca aacgtttttg ccataaactc agcgtatccc gggatcggga ggttgccaat 3622321 gatgaggaaa aaggaaccga tgataatcag gggcatcgtg aggatgatac catcacgcag 3622381 cgcctgcaaa tgacgctgtc ccgcaattct tcccgctata ggcatgacct tttcttctaa 3622441 gatctgattg actttattca catagcccgc ccctctctat gacacatgtc caagctgttc 3622501 agctgatttc agcacttccg ccccattgca cgttccataa tggacggtat taatgacgtc 3622561 taccggaacc ccctttgact ctcctaattt tttgagctgc ggaagcatgt aacggacttg 3622621 cggaccgaga agcaatacat ccgctttatc gatatgattt tgtacagaat cgcctgaaac 3622681 tgcccaaatg gtatagtctt ttccctgttc ctgcgcactt ttttccatct tgctcaccag 3622741 taagctagta gacatgcctg ctgcacaaac gagtaatata ttcatgtaaa agacccccta 3622801 gagtttgatc aattttgtaa tgtcctgctg ttgctatcat catattatga aatcgctttc 3622861 ataaacactc agggtttttc cgcaggcaac ggaaaaaagg tatatacagg ctgtcagctc 3622921 agcatttttt ggtcaaacac atccgaaagc tcttgatatg aacggcattt gatcagctgg 3622981 ttcatcgccg ccgggtcatc caaaatgctg ccaagcagtt tatacatgct ttgtaaatcc 3623041 gctttgttct ccttttcgac acaaagcaga cagacaaatt gaactcgctg actctcccaa 3623101 tcgatcggtt ttttgagcgt acaaacggcc caaaacgttg ttttcgtctg cggaacaagc 3623161 gggtgcggga tggcaacaag attgccaaaa cacgttggcg acatgtcttc tctttcaaaa 3623221 atggaatcta tgatttcttc atcggcaaag ccgcattcga ccactttctg ccctaaaaat 3623281 tgaatcactt cttcttttga gcgcagatcc tcctgaaaaa aaacgagttc tttttttagg 3623341 tagcgattgg ctttttcctt ttcatcactc agaatagatt ctatttttgt aaagtcagtt 3623401 ccgcctaaga tggtgttaac cttcagtact ggtacaggga gctctttttt aatcggaatg 3623461 gtgctgatga caaaatcaat tgattcgtag gacatttgat caagactata atactcagcc 3623521 gttccaagaa tatcgagccg cttgccgaaa tgggaacgca gtttttcgcg cagaagctgg 3623581 gcgcttccgg ctcccgatgc gcatacaatg atacagcgtt tcggcgggct ttctgttttt 3623641 tttcgttcaa tcgcggcgcc aaagtggaga gccaaatatc caatttcgtt ttcatgaatc 3623701 tcaatacccg tttgttcctt tatcacgatt ccggcaatga tcccggcttc aaaagcgagt 3623761 ggataatgtt ccttgatcgc tgccagcatc ggatttcgaa gattcatgcc gtatcggttg 3623821 cggctgatcg ccggcttcat atgcagtgcc aagccgattt tcagctcttt gtcatgcagg 3623881 atgccaagct tcagttcacg atcaacagct ttgatcatgg caagtgtcag ctgatcggtt 3623941 tcctcttcta ttgaaaatgt gtcctctccg cattgtgatt gtgtcattcg ttttgtgcca 3624001 aggagatgca tggtgatgta ggccgtctcg tctttcggaa acgtaacgga aagctttgat 3624061 tccagctctt ttacgatggc ttctgcagcc tggtactcct tttgatgcag gatatgatcc 3624121 atatctttcg ggaaaagaga aacatagttt tccgttctga tccgtttaca ggcgatagcg 3624181 atatggataa tgaggttatt cagtcccatg ttggacagag ggatgcggtc gtttttcatt 3624241 tttttcaaga tggcggaacg gatgatctca atttcttctt ttggcaaaat atcagccttt 3624301 tcatttaaaa catctatctc cgtttctctt tcatcaacaa tgtactccgc catgcagtac 3624361 ctcatctgca cctcgtcccc gcgcagcttg aagccgtaat tcggacgtgt ttccatgacg 3624421 atgcggtaag gcagcagacg tttctttact tcctttaaat ccgtttggag tgtagatttt 3624481 gagataaata gttcttcagc aagttcatcg agcttgagat aatggtccgc cagcagcaga 3624541 cgtttcataa gataggccat tctctcctcc ggcaataccg gcaggccctt tttttgctga 3624601 aattcatctt gcagcagtgt tctgaatact tgctcgtcat caatgcggag cttgtagccg 3624661 gagcctctta cagattgtac aaaggcaccg tggccgctta gcacaccttg aagttccttt 3624721 atatcattgc ggactgtccg cgtcgttacg tttaattgcg cggcaaaaaa cgaacttgtc 3624781 accggggctt cagccgccat cagcaagcgc agaatatcac gtagtcgccc atgaagcatg 3624841 agaaaaacct cctaactagt agatgcaggg attcagtgaa taggcagaaa ggatgatgaa 3624901 gggatgcgaa atgtatataa attctataat ggagagaatg gcaagtcaat gaacatccgg 3624961 aggactagag ggaaaactga cctataaaaa aacagccggg atcagccggc tgttctagat 3625021 gcggacatat tcttttgttt agacgccttg cggtccttca tgatttttcg aacaatcggg 3625081 taaatgaccg gcgcccattt gataacggtt ttgatcatct ttttcaaagc tccgattctc 3625141 ccttcttttt tctcaaccat tcccctgatt gcctcttcct taaacatgct aacgcgacac 3625201 gtacctgttt cccgtcaccc agaaacgcca tggataatcg cgtgcctccc cgctgttgtc 3625261 aatgccgatg cgcgggccgg ttgaaattgc ttccggtgtg tacccgcttt cgatgtaaag 3625321 cggctgttcc gtgatccagc gtccgtagtc attcatcgtg acgccaagcg ctttcgtcag 3625381 ctttcctggt ccgtttgtcc attccctcgg actcctgccc ggccttctct cctccattaa 3625441 cagctggcct tcatgcggct caatcgccct gattaatact gcttgcggga catcctcttc 3625501 cgccgcaacg acattcagca atgtatgggt gtgcatcacg tatgtatata cccgcccagc 3625561 ttctgcaaac atgatctcag tccgcttcgt ccggcggttg ttaaagctgt gggccgctct 3625621 gtctccagcc cccatatagg cctctgtttc cacaatatag cctgacgctg tgccttcgtc 3625681 tgtttctttt acaagaaggc agcccagaag cgatggggca agctcaagag cggttttttg 3625741 ataaaacgtg atgggcagcg gatttttttc tctcgtcacg aatcgacctc tccttttacc 3625801 gatttttgta cattgtacca ttcccgaagc agatcaaaaa aaacggctgt tttaaaatct 3625861 ttccattcag ggaatattgt taccgttcaa aaaaggaggg ccaaccattg aaagatgatc 3625921 atcaaaacaa gcagcaccaa tcaaatgccc aagggagcga ggaagcgttt tctcataaga 3625981 catccgggaa aaacgagtca gaggatacct taacgaatag gcaggggcat cctgttactg 3626041 acaaccagaa tgtgagaacc gtcgggaata gagggcctac aacacttgag aactatgatt 3626101 ttctcgaaaa gatcagccac ttcgaccggg aacgcatccc agagcgggtt gttcatgcca 3626161 ggggagcagg tgcacatgga tattttgaag cgtacggaag cttcggagac gaaccgattt 3626221 caacatacac aagggccaag ctctttcagg aaaaaggcaa gaaaacaccg gcatttgtcc 3626281 gtttttcaac tgtgaatcat ggaaaacact cgcctgaaac attgagagac ccgcgcggtt 3626341 ttgctgtaaa gctatataca gaagacggaa actgggattt ggtcggaaac aacctgaaaa 3626401 tcttttttat ccgcgacccg ctgaaatttc cggatcttgt acacgcattt cagcctgatc 3626461 cagtgacaaa catccaggat ggtgaacgta tcttcgattt catttctcaa tctcctgaag 3626521 cgacacacat gatcaccttc ttgttttcgc cttggggcat tccggccaac taccggcaaa 3626581 tgcagggttc aggcgtacat gcctataaat gggtgaatga ggagggcaag gccgttctcg 3626641 tgaaatacca ttttgaaccg aagcagggca tccgcaacct gacacagaag gaagcagaag 3626701 agattcaagg gaaaaacttt aaccatgcca cacaggatct atatgacgcg attgaaaatg 3626761 gcgattatcc agagtgggaa gtatatgctc aaatcatgag cgatgatgag catcctgaac 3626821 tggactttga tcctcttgat ccaacaaaac tgtggtataa agacgatttc ccatggaaac 3626881 cgatcggcaa attggttctg aacaaaaatc cggaaaacta ccatgcggaa gtggagcaag 3626941 cttcatttgg aacgggagtg cttgtcgacg ggcttgattt ttcagacgac aaattgctcc 3627001 aggggcgtac gtttgcctac tctgatacgc agcgctaccg tgtaggcgca aattacctgc 3627061 agcttccgat caactcgccg aaaaagcatg tcgccaccaa ccaggaaggc gggcaaatgc 3627121 aatatcgggt cgatagagca gaaggacaaa acccgcacgt caactacgag ccatccatta 3627181 tgggcgggct gaaggaagcg aagcaagacg gaaaagacca tacgccgcat gtcgaaggtg 3627241 atgtaaagcg tgaagcgatt gacagaacaa acaacttcgg acaggctgga gaaacgtacc 3627301 ggagatttac tgaatttgag cggaacgaat tgattacgaa tttggtgaat acgctttcta 3627361 cgtgccgaaa agaaattcag gatcaaatga ttgagaattt cacaaaagct gatcctgact 3627421 acggaaaacg cgtagcagaa gggctaaaaa aggtctccga aaacaacagc aacgggccga 3627481 tcggcacaac tgaaacggaa caggctgcaa agcaggctga acaggagagt catccgtctg 3627541 atccgtatta acaacagcga acagggcttt tttagaagcc ctgttttttt atttttctat 3627601 tgaaacgctt tcaataattg tgttgtactt ggaaggaaag gggtggagag atacgatgga 3627661 attacagcag gacttgattc ctcagaaaaa aacaatcggc gctttagatc acgccgtttt 3627721 tttatgcatg gtattttgtt tctggttttc aggctatatt tacgttcctg tattcagtct 3627781 gtatttggag gatctgcact tttcatatgg cgcaatcggc atcattctcg gcagctacgg 3627841 ggtcacgcaa atccttctgc gattcccgct cggccttttg tcagacatcc tgttttcctt 3627901 gcgcaagcaa ttgttaattg ccgggttcgg cttttccgtc ctcagcagcc tgctttttct 3627961 gatgtttgat tctttcttct tcgtgctggc cgcccggctt ttcgcgggaa tcactgcttc 3628021 tacgtgggtg atggcgacca ttttatacgc acattatttc aacaatggca atgcatcaaa 3628081 agcaatgggc atcatgcagt tttttaccgt catgcctcag tttgccagca ttgtgttctg 3628141 cgggctcgcc gcagcccatt tagggaggca ggttcctttt tggatggcgc tggcagcttc 3628201 tgccgcaggt ctggtgatct gctgctttat tcaggatccg tctgctcctc ccgcaaaccg 3628261 tggcaccatt cgtgtcaatc agtacatcaa agatacattg cggctgccaa agctgaagct 3628321 tttcaccatc ctgtctatga cggcccatgc cgtattattt atcacagtgt ttggttttac 3628381 gccgctttac atgaatcagc tcggaatggg cgacgcggag ctgctttggg tgatgagcgc 3628441 ctttttcctc ccacacgcag ccgccacatt aagctttgtg tttctgcgct ttacaagccg 3628501 tatcgcttac tccgtgatgc tcattagttt cgctgtcacc ggggtctgtt tgctatatgt 3628561 tcctttttta gctgcattgt tcacggtttg catcacacac gcctgtattg ggctggcgct 3628621 cggcttcgtt tttcctctgc tgctaagcca tgtcgtcgaa atcagttctg cccgtttaaa 3628681 aatgtcagtg atggggtttt accaatcatt ttatgcgcta ggcatcttcc tcgggcccct 3628741 tcttgccgga aaaatcgcac agcttatcgg gcttgcggga gttttttatg gagccggttc 3628801 tctggcattt gccgcctttt ttgtgatgct cgcgcaaaaa cgtaacatga tcaattaata 3628861 gctttcatac cgccggaagc gccacacaga aaacacggcc agaagcatga tgcacagaat 3628921 ggagaaagtg agtgaccatc cgaaaaaatc tgcccgctct ccatgaagaa ggatatgctc 3628981 cgcctgcttg caaatctcag ccggaagcca cttcgcacca tctggaaata gtgaaacagc 3629041 aaaggaaacg gctgctgtga gcccgatccc gcaagccgca gctgctccga cagaccggaa 3629101 tatcgtactt ccggcaaggc cggcggtcac aataaatatc acccaaagag cgtaaaggcc 3629161 aaggcttgcg gcaaagcggc tgaatgatgc gtcctcaaac agcagccgga cgtaatagta 3629221 agcaagcccg tatccagctg caaacgacat aatgccgatc acgctttgga tgagccattt 3629281 actcacgata taatgggctg ccgtcacagg ccgcgacata atcagcgctg ttaccccttg 3629341 atttctttca ttggctacac tgcccatcac gctaaagatg accagagcca tgccaagcgt 3629401 gttgaattga gaaagcgtgc tgaccatcac ttcagacccg gagggcatcg taaaactgat 3629461 tttcatgccg tcaggaaggt tccctccatg tgcgatgatt tccggcatat aataaatggt 3629521 cagcggctgt gtcagcccga cgatcatcat cgcaatcggc agccaaatca gcttgccgct 3629581 tttccatcct tccagccact ccttctgcaa tagcgccatc atcaccttca tgcgtgcacc 3629641 acctttagat agacgtcttc tagagactcc gttttctgtt caaagcgggt gacggtcaat 3629701 ccctttcgga tacagtcact taataatgac cggccagcgt gtatatcagg cagctcgaaa 3629761 accgcttggg acggattctt atagacaata gctgagacgt aaggcttctc ttcaagccaa 3629821 ccttccagct tctctttcac tgaaagggta aaaacgttcg tttgctgctg ttgtttcagc 3629881 tcctgtaact cgcctttcca tgaaatctca ccgtttttca taatcaccac ttgatcacac 3629941 acctgttctg catcgtgcaa aacatgtgta gaaaacagaa cggccatatg ctttttcagc 3630001 tcccgcatca tgtccagcac ctcgaaccgt cctgtcggat caagcgcaga caccggttca 3630061 tccaatatca aaaacttcgg tttatggagc agtgcctgtg ccagaccgag tctttgtttc 3630121 atgcctcctg aatagccccc gatccttttg tgcgccgctt cgtgcaaacc gacaaattcc 3630181 agcatctcgc cgattttctc ttggcatttt ctcttcgaaa ggccggacag tctccccgca 3630241 aatgtcaaaa attcatttgc ggtcatccac gaataaaaag caggatactg cgggaggtac 3630301 ccaatcaaac gccgatccag ctttttctct cctaacagct ttatggttcc agaggttggc 3630361 gaaagcagtc cggccagcat ttgcagagtc gtggttttgc cggctccatt aggtcctaat 3630421 agtgcgacac actcattttc attcacgtga aaactgacat tctttacagc ttcatggtgc 3630481 ctgtacgatt tgcataatga ttcaatagac agcatatcgg cttacctttg ctttctgccg 3630541 acggtgaaaa ataaaatcgg cccgataata ttgatacata cgatgattgc agcccacatc 3630601 cactttggcc cgttcgtccg ctcttctttt atacagctga taagggcaaa caccgccaaa 3630661 gccagctgta atacaatcag cggcaaaatc atttcccaag aaatattcat tgcttgatcc 3630721 cccttttctt ccgatccggc ctaatgacaa aaaagtaata acaaatcaga ggcatcggtg 3630781 cttgaatcaa tccgacaatc ccccaaaccc atgccatgtg attacgtttt ttcgcatcaa 3630841 taaataaaaa gattccctgc gccaatacga tgagacaagc cgcaaccgtt atgataattt 3630901 ctgtttgtgt catccgcgtt tcacctcgca ttcgccgaga tgcctttttt tctcagccgc 3630961 aatcaaaatc ggcagcaccg caagcacaca aacctgaagc acaataaaca cagcaggagc 3631021 ttgagtgaaa gctaagattg cagcactcac aaccatcagc gcgcagaata caaataaaat 3631081 gatctcttga agaagttttt ttctgtattc agctttcatt tgtgacagct ggtgaagcag 3631141 ttctttttga ttcggtatag agggattggc tgtttgatca atttttttcc attctgactt 3631201 taaatgatca gaaagctttt ctttattcat catcccactc ctttctgatt tgctggagcc 3631261 ctttatgaac tctggacttt acagtgcctt ctttgatttg aagcatcacc ccgatttcag 3631321 cgtaggtata gccgtagtaa tgccttaata aaaccggtgt gcgcagttta gggtccagct 3631381 ttgaaaacag atcgagcgtt tcgctccact ctgccccttt cgccgacacg tcccacttga 3631441 tcttgcggat tgtttcctcc gtaactgtct gattccgttt ccattctctc tttctctttt 3631501 tctggtgatc gagatagagc cgcgatgcaa tggagatcag ccatgtggag aattttgaac 3631561 ggccctgaaa gcttcttaaa tggatgtacc ctttcagaaa ggtttcctga acaagttcct 3631621 cgctgagatc ggggtgaagg gaaagcttta acaagtattt atataagaaa gaatagtgat 3631681 agtggaaaag ggctgtaaac gcctcgtcgt ttccctcttt cgcctgctgg atcagccgct 3631741 gttcttcttg tgtatccaat gaccgtgatc cccccttttt tgtttttctg ccttatgaga 3631801 cgacaccgga ttcaaaagcg ttcatctttt ttacaattct tttcagccat tgacagatca 3631861 ggcttcccgg ccgtttggct gcatatcctt atttgtaaac ccccttatag tctgttaagc 3631921 tatgacttta tgtcgatttc aaaaaaacat ccaatatgga ggacgatgca ttgaaagtag 3631981 aaaggcgaac gattgaatat attccgaatg aagaaagaca tggtaaagcg aaagatttat 3632041 ttcccgtatg gttcggggct aatatgcata tcaccacgtt agtgaccggc acgattcccg 3632101 ttgcaatggg acttaatctg ttttggagtg ttgccgctat tatttgcgga accttaatcg 3632161 gtgccatatt tatggcttct cattccgcgc aaggccctca gctaggcatc ccgcaaatga 3632221 ttcaaagccg tgcccaattc ggcgtaatcg gagcgattct tcccctcttc ttagtcatgt 3632281 ttatctacct tggtttcttc gcaagcagca cgattctggc ggccggaacc ttaagcagct 3632341 ttgttcccat cccgggatca tggagcatta taggcttaag tgccgtatgt tttttactca 3632401 ccattttcgg ccatgatttg attcacaaaa tgcaaaaaat cctttcttgg acctcttttg 3632461 ctgtattttt tgctgcaacg attctcattt ttcaattgcc gattccggca ggcagctgga 3632521 tacccggagc gattgatctg ccaattttcc tagtggcagt cagcgcagtt gcgacgtggc 3632581 agcttgccta cgcgccgtat gttgccgatt attcaagata tctgccagtt aaaacaccgg 3632641 cttcaaaaac attttggtac agctatgcag gtacatctgt cagctccatc tggatgatgc 3632701 tgctcggcgc attgctgaca acctcacttc ctgactttac ggcaaactca ggcagccaga 3632761 ttgtccaatt gttcggtccc ttctcgttta ttatgctgat cattgtgcta tttgggcaaa 3632821 tggcaatcaa tgtttttaac ctgtatgggg ctttcatgtc cacgacaaca acgctggagc 3632881 cgtttctgaa attaaaagtc acgcccaaag tcagaatcat catgatcctg ggtgtcacgc 3632941 ttgtcggcac agtcttaagc ctactgggac agagcaattt tatggaactg tttttgaatt 3633001 ttatcttttt catcagttat ttcttaattc cgtggacggc aatcaattta gtcgattact 3633061 acttcgtccg ccacggaaag tatcaagtca aagccatgtt cgacgtaaac gggccttatg 3633121 gaaaggtcaa ttggatcacc acaattgcgt tcgttctgtc tatcttgctg gaaattccgt 3633181 ttatcaacac aagcttttac atcggaccgc ttgccaaaat gtttggcggc ggagacatcg 3633241 catggattat cggcttggcc gtgccttctg tgctttacta tgtattaatg aaaccgcgtc 3633301 tgaaaaaacg ggcggggtat caagaaaagc tgtcttctct ctgaagacag cttttttatc 3633361 attcaaatcg tttccacacg cggggcagga tgtcagatag ctcatgagcg agcaacgtat 3633421 gagcggagtg ctcgtccgtc cagagctcgg cgcacgcacc atgcaaatag accgcgttta 3633481 atacggcgtg ctttggatct tcatggcagc agagcatccc caatatcatg cccgtcagcg 3633541 tgtcaccggt tccgcccttg gcgagcgccc cgtttccggt tggattgagc cagcagtctc 3633601 catcaggaaa cgcgatgacg gtttggtttc cttttaacac aatgacagtc tgcagctgag 3633661 ccgcccattc ctttgcatat tccgctcttt ttttctgcaa ttcgttcacg ggcacccctg 3633721 tcattcggaa aaactcgccc gggtgcggcg tgaggatgac ggggccctcc cgtttcggat 3633781 atgtgcgctt cgccagcgct ccggcatcca aaataacagg acaatcagcc gtaagcacat 3633841 gatcgactgc ctgctgtacg ctttccgttt gcggaaggcc cggtccgatg gcaatggccc 3633901 ggtacgtctc ttcaagctga gcatccgccg cctttttcca gccgtcacgc caataggtcg 3633961 cctcgggcaa aacaggaaca attagcggga ttacgttttc tgatgtaccg atgacaagct 3634021 tgccgagacc gctccgcatg gccccaagcc ctgcaagcag cgctgctccc ggcatgtcgt 3634081 cacttccagc cagcagcaaa gccgtaccgt acgtgccttt atggctctcc gcatctcttt 3634141 caggaagcgt ggcccttaca tgctcttccg tccaaaatgg aacattcatc tctatccctc 3634201 ctctgctttc ttttcctatt tttcctgtcc cttttctttt tcaaacaaaa aagacagcct 3634261 tttagggctg tcttttattt tacaggaaca tcaaggtgat acaggcggcg atatcgttcg 3634321 tttgccgcca gcagctcctc atgggttcct tccatttctg ttttgccgtt ttcgagaaat 3634381 acgattttat cggctgcttc cactcccgcg agatggtgtg taatccataa aatcgttttt 3634441 cctttcagca cctcaaacac cgtttccatc aattcacgtt cggtaatagg atcgaggccg 3634501 actgttggct catcgaggat gatgatcggt gtatcctgca gcaaaatcct cgcaagtgcg 3634561 atccgctggc gctctccacc ggaaaaacgg atgccggttt cttgtacaga ggtatgatat 3634621 ccgtcaggca atgactcaat gtagtcatgc agcttgacct gctttgcggc gcggcgcaca 3634681 tcctcgtcgc ttgcttctcc gtttccgagc ctgatgttgt tcaaaatgct tgtatcaaac 3634741 aggtgcggtt tttgatttaa cacggccacc gcatccgcaa tctgatcctt taacagcgct 3634801 gtctccactc cgtttaacgt cacagaaccg gagtccggtt tcaaggcgcc ttcgattaat 3634861 gcaagcgatg ttgatttccc agagccgctt cggccgagca gcgccatttt ttctccttgg 3634921 cgcagcgtaa aggaaaagtt gtgcagcact tggctgctgt tgtcataaga aaacgtcaca 3634981 tcacgaaagg ccaaggtgac atcttgaaga tcgagaattt gatcccctga ttcagtttgt 3635041 gacgcctccg gctgaggagc cacattgttc atgcgtctga tagaatcctg atagcccggc 3635101 acttcgccta aggcatccga aagcggcaaa aaggcttccg tcaacggaaa caccactagc 3635161 acaaaagcgg caatcatcgt tttagcgagc tcgccgtccg cttgctgtcc cgctgtccaa 3635221 aacagcatca gcaaaataag gccagcgaca aggcattgcg cagcaaagtc ccgccatctt 3635281 gtaaagcgtt gttttttccg ttcaagctca aaccaatcac gttcctcttt ttcataagca 3635341 tcaataaaag catgccggcg tccgctgaac atccagtcgc tgacacccat cacagcatct 3635401 gtcagacggc tgtacagcac attccgtccg cttttcagct tcgcattctt cgctctcgtc 3635461 acgagcaaag acacaaccgg aaacaataca acaagaacaa acaaatacag cgcaagcaat 3635521 atggcaaacg gccaagagaa gaagccgagc gctatcactg acacagcata caggagcaag 3635581 gctgagatcg caggaaaaat cgtttttaag aaagcatcct gcaaatgctc aatatcctca 3635641 gacaaaatgc cgagcatatc ccccgtgcga aaacgggaac gcagcatcaa agcacccggc 3635701 tcaagcatat tgtaaaggcg gacgcgcatg tcagatacga ttttcaaaat gatgtgatgg 3635761 ccgacgagcc gttccacata tcgcgacaca gagcgcgcaa tcccaaaggt gcgcacagcg 3635821 acaatcggca cataaatgag cagaatgttt tccggccttg tcgccgcttt agaaatcaaa 3635881 aaacctgagg tgaacatgag aaaagcagca gaaaaaatcg tcaccgcacc caaaaagata 3635941 accagaacga acaggcgggc attttgcttg atatacggca aaatccattc ttctttcttc 3636001 atgctctttc ccccagttgt gccttcacga gtttggtata cacaccgttt ttctccagca 3636061 gttcattgtg agtcccaatt tccgcaaccc tgcccccgtc aagcacgata atttcgtcca 3636121 tatcgagcat ccagtgaagg cggtgagtcg cgagaaagac gagcttatcc tcaaataaat 3636181 ccagcatcgt ttcttttatt tcatattctg tttcgatatc aagatgggcg gtcggctcat 3636241 ccagcagcag gatcggacgg tttcccaaaa aggcgcgggc cagcgcgaca cgctgtgcct 3636301 ggccgccgct gagcgcccgg ccgccttccc cgatccgccc ctctaatccg tcaggaaggt 3636361 tgttcaccag ctccgtcagt cccgctgagg cagcagcacg tgttgtatcc tctgccgaag 3636421 cgcttggatg gtagaagcga atgttgttgc caagcgtatc atcaaaaatg tacggatgct 3636481 ggggaatgta aagaaggttc ttctgccagc tgccgtcctg caaatgggac cggcttgtac 3636541 cattaacctc aatcatcccg ccatccggct ctaaaaatcc gccgagaata tcaattaatg 3636601 ttgattttcc ggcgccgctt gcaccgataa tgccgatttt tttcttgcct ttgaatgaga 3636661 gatgaatatc agacaccgaa cggccgactg acacgcctga cagcttcagc tcatcctgat 3636721 cggaccaagc ttcgagctga agcggcgtct cttctttaaa accaggctgc gacaaaatct 3636781 cttgaatggt ttttcctgct tcctggccgt tcagcgttgc atgataatca ttccccactt 3636841 cccgcaccgg caaaaaatac tcaggcgcca gaataagcgc cgttaaagca gggccaagca 3636901 aaatatcgcc gtcaatgagg cgcaggccca gaaatactgc gactgtcgcc accgacagca 3636961 tcgtgaaaaa atcgagggcg aatgatgaca aaaacgccac ccggagtgtg ctcatcgttg 3637021 ccttgcgata ccgctcactc acatagaaaa tatttttgct gtgtgacttg ctcaaaccta 3637081 ggaaacgcaa tgtctccagc ccgcgaagag aatcaacaaa atgattggaa agtctctgat 3637141 aggatttcca ctgacgatcc gcttttctct gcgcgacaag gccgaggaga atcataaaga 3637201 tgatcagaat cggcatagca gcgactaaaa tgatggctga tgtccgatcc tgaaaaaaca 3637261 cataaatgac aactgccgca ggcacaatcg ccatgctgac cattttcggc agaaacagct 3637321 ccaggtagcg gcggaactgg ctgatgcctt ccatcgccag cgtcaccatt tgccccgtcc 3637381 cctctttctt tgcaaagcgg gggcctaatc ggaacagctg atcaagaaaa cttttcctca 3637441 aatctgctcc tgtccgggcg gcgtattgat agacgatttt ctgtcgcgcc accgtcatcc 3637501 cgtgccgggc gataaaagcg atgaggaaaa agccgatcac cggtaaaagg gaggtaatgc 3637561 ccttcccgtt gaacagtccg gttacggcct cactcagcca ctctgcctgc ataataatgg 3637621 cggctgtctg aatcaacgtt aaacaagtaa tcaaggtgag aatccgcttc attcctttat 3637681 atcgaaacag gtcttttccc attaataagt cataggctcc ttatggctga cgcgcttccg 3637741 gaagacataa tagctccaga tctggctgcc gatgacgaac ggcaatagcg ttaatgctgc 3637801 aattgacatg actttaagcg aataatctcc agaagaagcg ttagctactg ttaaatcgta 3637861 tgcgctatga agcgagctga ccattacacg agggaatagg gaaataaaga tcattcccac 3637921 ggtcagcgcc agaccagcgc ctgtcatccc aaatgtccag ccgtcttttt tcttacgaat 3637981 aaatacagcc gcgagcataa agcagatgac aatcaaaaca gcgagcggaa tggtaatctc 3638041 gccgcggcgt gtaaacatgt ctgtctgata cgcagaaagg gccgcgaagg caagaaccgc 3638101 tacaaaaaca acacccatta tcttttgcgc cattttccgg gcgcggtttt gcaaatcacc 3638161 aatcgtacgc agcgtgataa acattaatcc atgctggaag caaagaagcg ttaccgtcac 3638221 accgccaagt atagaatata cattgatata atcagataca tgtgcgtgaa tgttcatgtc 3638281 ggcatcaatc ggcatcccgc ggaataatgt cgtgaacagc acaccaagca caaacggagg 3638341 aattagactg ccgaaaaaaa cgacccagtc ccaaaccttt acccatttta aatgatccac 3638401 cttgccgcgg aactcaaacg cgaccccgcg gcccattaac gcaagcagca ctatgacaaa 3638461 cggaatgtaa taaccgctca gcatcgttgc ataccagttt gggaatgccg cgaaaatggc 3638521 gcctgcgcca gtcaaaagcc acacttcatt cgcgtcccag aacggcccga tcgtgttgat 3638581 cagcactctg cgttctaatt cattatggcc aagaaaacgg gtcgccatgc cgaccccgaa 3638641 atcaaagcct tccaaaaaga agaatcctac aaacaataca gcaacgagta taaaccaaag 3638701 atcatgaaga gatgccatgg tatacctcct gactaaatgg atctgttgat acaggcacat 3638761 catgatgatt atcatgctcc gcaccttttt taatctcacg gataaacaag aagacaagca 3638821 gtgcaccaag aatcatgtac atcacaccga atgcgatgat tgagaataac aaggaacccg 3638881 ctgttacgtt aggcgacaca gattgagcgg ttgtcattaa ccccataacc gtccaaggct 3638941 gacgtccgat ttctgtcata atccagcccg cggagtttgc aagaaacggg aaggaaatca 3639001 acgcgatcat gatgcgcaaa taccatttgc tgttttcaag ctttttacgg cggtttaacc 3639061 aaaggccgcc taacgcagca agaatcatga caacacctgc tcctaccatg atgcggaagc 3639121 tccagaatgt cgttttcact ggcggaatgt agtcgccttt tccgtatatt ttttcgtact 3639181 cagcctgaag ggttttcatc cctttgacac ttccgctgaa tttctgataa gccaagtagc 3639241 tcaaggcata aggaactttg atttcatttg agcttttttc attttttgta tcgatcgtcg 3639301 caaaagcggt ccaagcagca gggtcaccgc tgtcttccca taggccttca ctggcagcca 3639361 ttttcatcgg ctgtgattcc atcaagtgct cagcctgcat gtgtccgcta aggccgacgc 3639421 caagaccggc acaaagaccg acgatcattg cgagtttaaa agattgctta aagaacggca 3639481 cttctttttt cttcagcagt ttaaaagcac tcactccggc aataaagaaa gctccagtgg 3639541 caagcgcacc gaaaataacg tgcgggaatt caacccaaag ctgagggttt gtaatcaacg 3639601 cgccaaaatc attcatttcc gcgcggccgt ttttgatcgt aaagccgacc ggctcctgca 3639661 taaaggagtt tgctgttaaa atccagaaag atgacatgat cgttccgaat gatacgagcc 3639721 atatgcagag cgcgtgaatt ttcttcggca ggcggtccca gccaaaaatc cataatccga 3639781 taaaaataga ttccatgaaa aacgccaata atgcttcaat cgcaagcgga gcgccaaata 3639841 catctccgac aaaacgggag taatctgacc agttcagtcc aaactggaat tcttgcaaaa 3639901 tccccgttac aacaccgact gcgaaattta ttaagaataa gtgtccccaa aactttgcca 3639961 ttttgagata cagctcattt ttctttacaa gataaagagt ctccatcaac gcaaccataa 3640021 acacaagccc gatagacatc ggcacaaaca agaagtgaaa caacgttgtt gatgcaaatt 3640081 gtatgcgggc taataccaat tcactcatgc tttctcctcc atttccggtt aaaactgtta 3640141 atttgctcac tacttcacaa atagaaccga gactttgatc agtaattcac aaaatagacg 3640201 aaaaaaatat tgctcaatat ttcacaaatg tgtcaaaaag tcatccaata tgatgcaaga 3640261 ttgccagact gaccaaatga cacaatctct gactggttca tattaagtac tttacaacga 3640321 ttcatttcaa aaataaagcc taaaatacct aaaaagtccc gcactatgtg acggattttt 3640381 gtctattttg ttgcttattt atgtcggctg ctaggataaa tgacccttta ttatcgtaca 3640441 tcaacacatc gttccttgcg aacaaaatgc ttgcccccgc cccagcactc gagtctcagc 3640501 attccgtctt aaaccgattt tagtcagaat gcctcttttc atttgaaccg gtaagaggag 3640561 aaaagttgaa tagtaaattt ttaatatatt aataatttca attttttagt atacttaaca 3640621 tagtgaacaa tttcactgca tcaagaatag gggaggtttt tcaatgggag agcttcaaac 3640681 acacatgcaa ttgcaaacgg atacaattca cgaaggggtt cgaaaagaga attggtttgc 3640741 gaaagccatg aatataaaag taggcatcat accgcttcct gtgtatgcct tgctgtttat 3640801 attaatcact gtttttgtta tgcatcacga tgtaaaaagt gacattttga catccattgc 3640861 cgtcatggcg tttttcgggt ttacctttgc ccaaatcggc aaatcgatac cgattgttcg 3640921 ttctatcggc ggcccggcca tcctagctac ttttattccg tccgctgtcg tgtactatca 3640981 cctgctgcct aatgatatcg tcaaatccac cacagaattt acagaaaact caaactttct 3641041 atatttgttt atcgccggta ttgtcgtcgg aagcattctc ggcatgaaaa gagaaacact 3641101 cgtaaaagca ttcatgaaaa tctttattcc gcttattgtc ggttctgtca cagccgctat 3641161 tgtcggactg gctgtcggga cattgctcgg actcggattt cagcataccc tgctgtacat 3641221 tgtcattccg atcatggctg gaggagtcgg agaaggcgct atcccgctgt ccatcggata 3641281 ttctgacatc atgcccattt ctcaagggga agcgtttgca cttgttctgc catcgattat 3641341 gctgggcagc ttgtgcgcga ttattctagc gggattgctg aaccgaatcg gaaagaaaaa 3641401 accggaatgg acaggcaacg gcaaagtgga ccgctccgaa gaagagtccc ctgcgctgga 3641461 ggaatctcaa agcggacagc aaatgttcaa cctttcttta tttgcgtcag gcggtatcct 3641521 tgctgtttct ttatacttag tcggcatgct cgctcacgat tttttcggtt ttccggcacc 3641581 cgttgccatg ctgttactgg ctgttctaat caagctgttc agattggtgc ctgcctcaat 3641641 tgaaaatggc gcgtttggag tgtcccgctt cttttcaaca gctgtgacct acccgcttct 3641701 ctttgcgatt ggggtatcca tgacgccgtg ggacaagctt gtcgccgctt ttaacctcag 3641761 caatattatc acgattctgt ctgtcgttgt gaccatgatg gccgttggct tcttcactgg 3641821 aaaatggctg aacatgtatc cgattgaaac cgccattatt aatgcatgcc attctgggca 3641881 aggcggcacg ggtgacgttg ccattttaag cgccgctgaa aggcttgagc taatgccttt 3641941 cgcccaggtg tctacccgca tcgggggcgc gattacagta tccttaacct tattgctgct 3642001 gcaccagttt tattgatccc cgcaagcaag ttcttcgtca aacgaaagag cttgcttttt 3642061 tgcatgtcca tgtttttgca agttcccatc ccatgctata gtaatagttg gaaatactag 3642121 atagaaagga atctggcatg cctatgggaa ctcatctatt tctctttatg cttctcgggc 3642181 tgggatttta tttgatatca gccctagctg caaaactcat tccggccata gacttctgga 3642241 ttgatattgt tctatgggtc ggcgctgcgg cttacatctt ctctcatctc tcattcatgg 3642301 acggcattgt ctcactcgcg acaatgttct actgctattg gaccgcaatg gatctcattg 3642361 tttcagagcg tgtggaaaaa ccttcgggag actggcagga aatcgagctt gccaaaaaca 3642421 aaacacgcct cctgtcagac attacgctga ccgccattgt gtttgcaggg gctgtcattt 3642481 ttttcatcta tggacctgac acaagccctc tcaaatatgt gatccttctc ggaatgatct 3642541 ccggcggagg ggcacttgtg aagcgaatac tgaatgtttt tagcgtaaag gttttttatt 3642601 cagcagcctt agaaaaattg catatcagct cacactatga aacccgtaca tacccgcttt 3642661 ccgatttgaa gaacattcag cttgaatcaa cagcagatct cttaaagctc catccgcttc 3642721 tgacgatgta ttcatcccgt ttagatttga caacaagctt tcagcaagtc attaaactgt 3642781 ctcttcccgg cgaaacactg tttctgacgg tgaaggaacc gcaaaaatgg aaaacaattc 3642841 ttcaggaata cacagatgca gaaaacaatg tggacaatgt gatttctgtt ttgccgtttt 3642901 atcatcgaaa aaatgtgaag cggctgctcg gtaagcttta ttttgccgcc agcgtaaaag 3642961 gggtatccgc ttacgcctta ttggtgctcg cgttatacgc attacacgcc tctccatggg 3643021 tcatggctgt tgccgtaatc ctatattggg tattcaacat gtatatgtca gaccgtgtgt 3643081 tgcgggcggc gatggacgcc aagtcttgtc atcatccgca tgtacaggcc gcggccgata 3643141 agattttcag atcggccggc atttcccatg tccgcatata cgaaacggag agtgatgatt 3643201 acaacggaat ggcagtaggc atgaatgtcg ggaggtcaat ggtcatcctg acaagcgcca 3643261 cactaacact tccacagcgt gtcattgaag gcattctggc ccatgaggcg attcatatca 3643321 aaaaacgtga cgttctgtca tcacagcttt tgcgttttct atatcttgga gctgtcgtgg 3643381 ggattttcct cttgtttgag cagcatatca cccatcccga ggcccacaaa attgcgcttt 3643441 gggctttcat tatggcaatc attatcctat tccagctcta tcaatccttt tgttcacaat 3643501 ggatggaggt gcgtgctgac aaccttggcg catcattgct ggacggcggt tacaaacaaa 3643561 tggctgaagc cttgagaatc ttggcggttc ggcaagatga ggatatacag aaacaaagtg 3643621 cctatagctc tgaagcaggt gaagacgagc ttcaaattga ttctctcacc cgtgataaaa 3643681 gctggttttt cagattgatt gattttcagt tcgctcctca tcctcctatg tattggcgtg 3643741 tcggcacttt attgtcaaac aaaggacatg gggtgctaaa gcgctggctc agagaccgac 3643801 tgaaagaatc gatcactttg aaatgaaacc ggtcagcgtt tcatccgtat aacagatatg 3643861 gtgaaaaaag ggagtgacgc gaagtgattg tgatcatctt attgtttata tctattattg 3643921 tttttctttc agtcattcag ccgcagccct cgaaaaacaa aagccgccag caggcggaca 3643981 gcgggtattt cggttattca gatcatagct cacaccatga tggatgcagc agtgacggag 3644041 gtttcagcga ttccggctgt ggcggcggag ggggcggcga ttaaacgccg ccttttttta 3644101 tttcattgat tcgatgtacg caccaaaagc cgagcctgac atgcctgggg acacgcgcac 3644161 acgatggagg gcatacattc cctggtctct cgaagccgcg cccggttctg tcgtcacgcc 3644221 catttgatag cctgtttttt cagcggcctt cagcgtctcc tcattgtagc gccctaccgg 3644281 atagctgatg atggtggttt gctgatgaaa catgttgtcg aacagctttt tcgaatcagc 3644341 catctcactt tgctgctgtt gaggcgttaa tccgttcagc tcaaggtggt caatcgtatg 3644401 gctttcaatc gatatgccgt gctgtgccat ttccttcatt tgttcctctg tcagatggtg 3644461 cttatgtccg atcgatttgc cgatcataaa aatcgttgcc ttcatcccgt actttttcag 3644521 caccggatac gcatcttgat aattgtcggt gtacccgtca tcaaatgtga tcagcacgca 3644581 cttctcactc ggttttttat cctgcgtcag catgagagat gcctctttcg gcgttaatgt 3644641 ctgatagccg ttatcatgaa gccacttcat atgcgcctcg aattctttct ttggcacacg 3644701 gaggctgttt cctgaagaaa tgctgtggta catcaaaatc ggcagctttg ccggtttctc 3644761 tgttttgatc catgcggatg tatcgtcttc ttttttctga acttgtactg cctttttttc 3644821 cggtttcttt tgttccgctt ttggcatcgg ctgctctgca ttcgcctctt gatcagcaca 3644881 agccgcaaga gccaaacagc tgcccaaaag aaagatgctt aaaaacaatc gtttcatcgt 3644941 tctcctgctt tctgtctatt tcttcctcct ttttcatcgg tttgattctg agattttcaa 3645001 tagcaaaaaa ccggacatgt ctccatgtcc ggtttttttg atcttatcgg attctcactt 3645061 ctgtctcact gtcaaagaaa tggcctttat tcatatcaaa tgcaaccgtc agctcatcgc 3645121 ccgattgaat atcgaggcgg gcgtcgatcc gcgcaataaa gtcttggttg tctatctgcg 3645181 aataaatcat aatttcagaa ccgagcagct ctgcaacatt aattttcgcc ttaatcgaag 3645241 agttcttata tgattccacg acaatcaatt catcatgtat atcctcagga cggatgccga 3645301 agatgacctc tttgccgatg tagccttttt cacgcagcac tttcattttt ccttccggga 3645361 cggttaatgc cgcagaaccg attttgatta agccatccgt gagctttcct ttgaaaaaat 3645421 tcatcgccgg tgatccgata aacccgccga caaagacgtt ttcagggaat tcatatacat 3645481 ccttcggcgt cccgatctgc tgaattttcc catctttcat gactacaatc cgtgtcgcca 3645541 ttgtcagcgc ttctgtctgg tcatgcgtca cataaatcgt tgtagtctgc aatctctggt 3645601 ggagcttaat gatttccgcc cgcatttgca ccctcagctt cgcgtccagg tttgacaaag 3645661 gctcatccat caggaacacc tttgcatccc gcacgattgc ccggcccagc gcaacccgct 3645721 gtctctgtcc gcctgacagc gctttcggtt tacggtgcaa atattcctca agcccgagaa 3645781 ttttagcggc ttcttcgact ctttttttga tttcaggctt cggcattttc cgaagcttga 3645841 gcccgaacgc gatattatcg tagaccgtca tatgcggata aagcgcgtag ttctgaaata 3645901 ccatcgcgat atccctgtcc tttggcgcta catcattgac ccgttttcct tcaatataaa 3645961 aatcaccttt cgaaatttct tcaagtcctg cgaccattcg cagcgtcgtt gatttcccgc 3646021 agccggacgg gccgacgaat acgataaatt ccttatcggc aatatgaagg ttaaagtcat 3646081 caaccgccgg ttccttctga tcataaaatt tataaatgtg ctccatccgc aattcagcca 3646141 tctaacatcc ccctttgtta ttgtaaacgc tttcttatat tgagtgtaac agcaattccc 3646201 tctcgctaaa atgggcagcg ttcataaaat cacccagcca tttttcgtgc atatttccaa 3646261 tttattctga actttcattt tgcaggcaga taaaataggc aagaagcgcg cctttgtacg 3646321 atttgatatc tatccctgac cgctcaataa atttatcaat ccgatattgc aggctgttgc 3646381 gatgcagatg cagctttttc gctgttaatg tgacgtttga gttgttttca ataaacagct 3646441 taatggtctt ccttagctca gattcacttc caaataaaag ctcagcttct tcagagagca 3646501 gtgtttccag tttttctttt tctgtttcta ataatagaaa aggaaagatc atctcaaagg 3646561 tcacactctg cacctgaggc agccgttttt cagcaaacag gaaatacgcc tgttcacgag 3646621 cgtaatgttt tcgcagacac tcatccggct cgtaaaatct tccggcgtaa aaacggacac 3646681 tgaagtagaa atcactttca agaaccttag cgagcgattc cagttcgtcc ttctccgccg 3646741 ccgcttcact ttcctgctcg acaatcacac ctctgtcctc atggatccac acaatcacaa 3646801 aagacaccgg ccaaaaatgg cgaaccgctt ccgtaaagga cgtcctttct attttgccga 3646861 ataaatgaaa gtgaacaaat ctcgtccgtt tctttatata cgccggcaat tcccctctgg 3646921 aaaaaaggaa cgaaaaccac ttgttttcct caggtgattt catagacagt tgattgccct 3646981 catccgcagg cgtcaaaaat gactgcagca ccaatacttc tttttcactg atctctgttt 3647041 tcggaatgga gatatatctc tgattgctct catcaaaaaa acatagacag ccttccctta 3647101 tgcaaagctc ctcagacaca atcgaaccgg gataaatagc cagcagcgat ttcatagagt 3647161 ctcctctctt atgtaaggat ctgtatattc agtataaggc gaaacacaca tgttctccac 3647221 taaaaaagag tatatccggt atagatagac gagaaactga aagggaaacc tcattcgttt 3647281 acatattggc ttcagcggaa atagaagaag acatgcagga ccaaaggagg gtcatcttat 3647341 gagtttcgaa acgttaaaca aaagttttat caacggaaaa tggactgggg gagaaagcgg 3647401 acgtacggag gacattttga atccgtatga ccagtctgtg atcacaacag catctttggc 3647461 aacgggcaaa cagcttgagg atgcgtttga cattgcacag aaagcccaaa aagagtgggc 3647521 caagagcacg acggaagacc gaaaagccgt gctgcaaaaa gcgcgcggct atttacacga 3647581 aaaccgtgat gacatcatta tgatgatcgc ccgcgaaact ggcggaacga tcattaaatc 3647641 aacaatcgag ctggaacaaa cgattgcgat tttagatgaa gccatgacgt atactggtga 3647701 attaggcggc gtcaaagagg tgccatccga cattgaaggg aaaaccaata agatttaccg 3647761 ccttccgcta ggtgtcattt catcgatttc tccatttaat ttcccaatga atctatccat 3647821 gagatccatt gcgcccgcaa ttgcgctggg taacagcgtt gttcacaagc ctgatatcca 3647881 aactgctatt tccggcggga ccatcattgc gaaagcgttt gaacacgccg gtcttcctgc 3647941 cggtgtcctt aacgtcatgc tgacggatgt aaaggaaatc ggggacggca tgctcaccaa 3648001 tccaatcccg agattaatca gctttacagg gtcaacagca gtcgggcgcc acatcggtga 3648061 aatcgccggt cgcgccttca aacgaatggc acttgagctc ggcggcaaca atccatttgc 3648121 cgttctttca gatgcggatg tcgatcgtgc tgtggatgcc gcgattttcg gaaaatttat 3648181 tcaccaggga caaatctgta tgattatcaa caggatcatc gttcatcaag atgtatacga 3648241 tgagtttgta gaaaaattca ccgcccgtgt caaacagctt ccgtacggcg atcaaaccga 3648301 tccgaaaacc gttgtcggcc cgctgatcaa cgagcgccaa atcgagaaag cgctggagat 3648361 cattgagcag gcaaagacag acggcattga gcttgcggtt gaaggaaaac gcgtcggaaa 3648421 cgtgctgacg ccgtacgtct ttgtcggtgc ggacaacaac agcaaaattg cccaaacgga 3648481 gctgtttgcc ccaatcgcaa ccattattaa agctggcagc gaccaggaag cgattgacat 3648541 ggcaaatgat actgaatacg gcctcagctc tgcggttttc acttctgatt tagaaaaagg 3648601 cgaaaagttc gccctgcaaa ttgacagcgg catgacccat gtcaacgacc agtccgtcaa 3648661 tgattcgccg aatattgcct ttggcggaaa caaagcaagc ggtgtcggcc gtttcggcaa 3648721 tccgtgggtc gtcgaggaat ttaccgtgac gaaatggatt tcgatacaga agcaataccg 3648781 caaatatccg ttctaaatga aaaaatccct ctgtttcaag tacagaggga tttttcttta 3648841 tttagatata tccacaaacc cttcgccaaa cacatcgcgt acgtcatgta cgatcacaaa 3648901 cgcttttttg tcgcagcttc taatgatttt tttcagcata gacagctcct gtttgttaat 3648961 gacgatatac aaaatctctt ttgactggcc cgtataattt cccttccctg ataaaatcgt 3649021 cacgccccga tccatcaagg tatttacctg ctctgcaatc tcactcttat tttctgaaat 3649081 gaccgtaatg gcttttttcg tattcaaacc ttcaataatg aagtccatca ctttggtacc 3649141 gatatacagc atcacgatcg taaacatcat tttttctgca ccaataataa aataagagct 3649201 aaatactacg attaaatcaa aaaacaagag tgcatagctg atattccagt ctaaatattt 3649261 attagcaatt ctggccagaa tcgcggaacc ggccgtcgtc ccgccgaccc ggataatcat 3649321 gccgatcccg actccggcaa atacacctgc gaaaatcgta ttaatgatca attcatcaga 3649381 cggaatgctc cacccatgtg tcagatgaag aaaaagcgaa tttgccgcaa ccgcaatgat 3649441 cgtataaacc gttgtttttc catcaagaaa cttgtagccg attaaaagca aaaacgcatt 3649501 taagataaag ttcgtgacac caggagacca ttgaaacaga taatacaaaa tcagcgtaat 3649561 cccagtgact ccgccttccc caagatcatt gggaatcgca aataaattaa ccgcaagcgc 3649621 gaagaaaaaa gcgccaatca caagcataag tacatccagc attctctttt tcatcacgaa 3649681 aacactcctt ttcattgttc tgttctagca aataaaaaaa cccaggagaa cgctctcgaa 3649741 aaagagcaga aactcctggg cttttatccc accgtgtcat aacagccaag ctgctatgtg 3649801 ttttctctcg gtcacagtcc aatttgcatt gcggaaccct agaaaaccac tgtttttatc 3649861 atatcctttt cactttccaa tattagcatt ataagggacg gttcgaattg gttcaagggg 3649921 tatttgcgga gttttcatca gataagctgg aaaaaaatac gatttatcta ttaaaaaaga 3649981 acagatataa ccgataagaa aaaaagcata tattttacaa gcgaatgtaa ctataaatga 3650041 taataattat aagaaattca taattttata ttgactaaga gaaataatat aggcattata 3650101 gtacatatgt ttcgtacatt ttattacata ggaggaaata taatggcagg aaaactagta 3650161 ccctgtaaag cttgcggtca agaaattgca aagggtgtaa aaaaatgtcc taactgcggt 3650221 aaggatcaac gtaacttttt tatgcgacat aaaatcatta cgtttattct cgcagttgtt 3650281 gtcatcatta ttatcggtaa tatgattggc ggcggaggcg gctcagaagc cacttccaaa 3650341 acatcaagca gcagcaaagc agaaactgaa aaaacataca atatcggtga taccgtaaaa 3650401 actgaaaaaa ctgaagtgac ggttacgaag gtagaggaca gagatactgt cggtactcaa 3650461 tatgttgaaa agaaagcatc tgagggaggt acaattgtag ctgttcaata tacaattaaa 3650521 aacgtatcta aaaagccgat tagctctttt tcaattccaa ctgttaaatt agttgatgct 3650581 gatggtactt cttatgattc tgatattgat gcttctgtaa actatgcaac tgagacaaaa 3650641 gttgataact ctaaaatttt gagtgatcta aatcctaata ttaaagtaac aggtgtaaaa 3650701 gcatttgaag ttgacaagga agcttatgca aaaggcactt ggaaactaaa attcagtaat 3650761 gatgttattg tgaaaatcaa ataacagcta acaagggtgc ctgtttaggc acccttgttc 3650821 tttaaaaaag gccttctcaa ttgagaaggc ctccattctt attccgcact cttataccca 3650881 ttcacattag aagactgcca tctccaggaa tcagcacaca tttcctcaag gccgcgtttc 3650941 gcttcccagc ctagttctcg cttggctttc gcaggatctg caaagcatgt ggcgatgtct 3651001 cccggacggc ggtccgcaaa acggtatgga acctctttcc ctgacacttt ttcaaaggct 3651061 ttgaccattt ccagcacgct gtagcctgtg cctgttccaa ggttgtatgc atcggctcct 3651121 gtagagttca atactttttc cagcgccttg acgtggcctt ctgcgagatc aacgacgtga 3651181 atataatcgc gtacgcctgt cccgtctttt gtcggatagt catttccgaa tacgcttaat 3651241 tgctcgagct tcccgactgc tacctgtgcc acatacggca taaggttatt tgggattccg 3651301 ttcgggtctt caccgatccg tccgcttgga tgcgcgccga acgggttaaa gtaacgaagc 3651361 agcgcaacgc tccactcatt gtcggctgta tgcaaatcac gcaatatttg ttcaagcatg 3651421 agcttcgtct gcccataagg atttgtcgcg cctaatggaa agtcttccgt aatcggcgat 3651481 gtttccggaa cgccgtatac tgtcgcagat gaactgaata cgattttctt gacgccgtat 3651541 ttctccatgg cctcgcataa aataaacgtt cctgtcaaat tgttatgata atatttgagg 3651601 ggaatcgcca cagattcgcc gactgctttt aaccctgcaa aatgaatcac agcttcgatt 3651661 tcattttcag caaaaacgga atctaccgct tcccggtcca ataaatccgc ttcgtagaac 3651721 gttaaatctt ttcctgtaat ctccttgaca cggttcagcg cttcagctga actgttggac 3651781 agattatcaa gaacaacaat ctcgtagccg ctgttcaata gttcaacaca tgtgtggctg 3651841 ccaatgtaac cggcaccgcc agtaacaagt attgccatga tgtaaaccct cctaaaaaat 3651901 gacctgtttt cattatatag tgtttagaac cggtccacat ccatttttaa gaagtttaat 3651961 cgtttattaa tagttttttc atatttttta gcttaaaccc ttgccagcaa ttcgatagag 3652021 gtttcagcaa gaatgtgctc tttcatttct tgatagagct cattcaagta aaagcccggc 3652081 tgaagattca gctcagcatc taaagcatag accgtcaatg tatacgcatg atccttgtca 3652141 ggcggtgtcg gcccgcaata ctggtgaatc acctttggat cgttgcttcc cgcaagcggt 3652201 gaagcaaagc tgttttgccc ttgtatcatc aagtcctgtc tttcctcact cgcatgttca 3652261 ggaagctctc cgatgtaagc cggaatatta gccgctgtcc agtgaatcca gctgaatccg 3652321 catacgggaa tggcgtcatg atcgatgaaa gtaagtgcga gcgtctttgc tccggacggg 3652381 atgtcatcaa aatgaattgg aaaggataca aatgggtttc cttctctctt atatttttca 3652441 tccgcgtatt ttgaatactt gtcatgtaaa tatggatttg cttctacgta tatgttcata 3652501 tgaatccctc tctctatttt ctcgttctat aggtatacta aacgaatcga tgtataatca 3652561 gtgataaaca aatacgcatg taaacgtaac aatttgttat ggataacttg cagtgaagga 3652621 gatatttcat ggatttaaaa tggctgcaaa cctttattgc cgcagcggaa tcagagagct 3652681 tcagggaggc ggctgagcat ctgtatctca cacagcctgc cgtttctcag catatgagga 3652741 aattggaaga tgaactggac atgaggttgt ttttgcatag cggaagacga gtcgtactga 3652801 ctgacgaagg caggctcttt ttgccttatg ccaaagaaat gatccatgtt taccaagctg 3652861 gaaagcagaa agtcagtcaa tggaaacagg ggtacagccg atcactcacg ctggccgtac 3652921 acccctacat tgcgtcctat atcttgcctc gctttctgcc agcctatatc caaaaacatc 3652981 cgcatgtcga gctttcaact catgtggctg gatctgacgc tattaaacaa gcggtggaac 3653041 acaatgaagc tgatattggt ttgtcgcgga aagacccgaa caccaacact ctttattatc 3653101 agcatatatg cgaaggtacg ctttgtctgg cggctccttt ccaagaaagc agaccggatg 3653161 ctgcatccgt cttaacccgc tatcggctgc taacgcatga tcatccgtca tatggggatg 3653221 cctttttaga taacatccga tcacattacc cgtatcttca aatgatggct gtcgggcaga 3653281 cggatacggc tgtccacatg atgaaagcgg gaatgggggc atctttcctc cctacctaca 3653341 ttatcaaaca ggaagaagcc gaaaaaaagc tgatggctgt cagcacgcct gcacatctag 3653401 aattgcctgc gtcccaaacg tttatgatgt ggaaaagaaa cagcgaagac attcagcatt 3653461 ttcacgccat gttacatgac tttatgcagc gcgaacaagt atagagctga aaaatcaatc 3653521 tgccggttga cgtttttctt tcctattttc gctatgctta atgcagaaag gatttgatga 3653581 catggcgatg agcccttata tttttattgt attgattctt attattttat cgatgtatcg 3653641 agaaagaacg gtaaagcccg ggaagttgct gatcattcca ctgttgctct tatggggcgt 3653701 atctgcatcg tttcagccgg cgtattttca ttccgtatta catgtggcga tcagcggcat 3653761 tttattactg atcgggctgg cctgcgggtt tggcattggg aagatggtaa atgtacggat 3653821 tcacccggaa accggaaagg tcacttcacg cggctcactt gggagtgtta tcctcattct 3653881 agtgatactt tctttgcgca tggccgcgag aacatggctg cctgagagca acgagatgtt 3653941 tattgccatt attcattcta tgttcttcgt tcccctcggc accatcacag cccgcaacat 3654001 catgctttac aaagcataca gacgactgac cgctggcaaa gtatccattc aataaccgaa 3654061 agaaggacca gcatgaacgg acaaactccg gctcggcact actacaagaa gcttgtgccg 3654121 agccttattc tcattttgaa ttgcatacaa tttttatctc atccaactaa ggctgatccc 3654181 attttgttag catttgtatt tgcggtatac ttagcattca tttggatcat tccctatgtg 3654241 gcatccactg ctgttagttt gagcatattc atcggactct ggctcctgac cgatttcttt 3654301 tgggctgttt ccggccaaga gcagggtgcc gcctattttt tgattgtatt tttaatgata 3654361 tatgccgcct ttagactccc ttcacggcta tccttgatct tcacagcatg tttaattgga 3654421 ggcaacatat tactcctatc ctcacaaggg ggaagcttga ataccatcat cagcaacatc 3654481 tcgatcatgc tcggtctgta cgtcctcttc tcctccatgc gtttcagacg agaagcgaga 3654541 agggaggctg aacggaatca tgctgaattg gcaaaaatgc atgtgcagct ggagcatgct 3654601 cataaagaac tccagaaagc gcatgcagag ctgcaggagg cttctgttct ttcattaagg 3654661 tacgcggtcc ttgaggaacg tacaagaatt gcccgcgaca ttcatgacag catcggtcac 3654721 gagctgactt ctgtgattgt tcagcttcaa tcccttccct atatccttaa aagcagcaag 3654781 gaggattcag aaaaagtcat tcaaaatgta ctgagtgtcg ccagggagtg tcttcaagaa 3654841 gtgcggtctg ttgttcacca aatgggccgt agtgaatcga tggtggggct taccgctttg 3654901 cgggggctca ttcatcaagt ggaggaacgg agcggcttgc acgtttcttt agatactgcc 3654961 ggactgtcag aagagtcttg gcctccaaac gtgagcgaaa cgatctaccg catcttgcag 3655021 gaagcgctga ccaatatcat tcgtcacgct gacgcttctc atgcggcggc cgtcatttct 3655081 aatgacaagt cccatctcta tgtcacaatc accgacgacg gacaattcac cggcagcctt 3655141 acttatggat ttggcctgac aggaatgaaa gagcgcgcag aaaaagcagg cggttccctt 3655201 actttcagtg ccgtacagcc gagcggcctg aaaattgagc tgtcattgcc gctcatgaca 3655261 acgaataagg agcaaaaaga tgaacaaaga taaaatacgc gtagcgcttg ccgatgatca 3655321 gccgcttgtg cgtgaaggct tccgctacgt catcaacgca cagacggata tgacggtttc 3655381 tggcgaggcc ggcgacggtc acgatattat agcactcgca aaacaaacaa aacccgatgt 3655441 catcctcatg gatgtccaga tgccgcgttg ctcaggcatc gaagcggcga aagacattat 3655501 gtccgcactt ccaaatacaa agatagtcat tttaaccacc tttgacacgg aagaatacgt 3655561 atttgaaggc atccgtgcgg gcgcagtcgg ctatctgctg aaggatacac ttcctgagga 3655621 gttgatagat gcgattcgcg ctgcggccag aggcgaggcg attttccgta cagtcacagc 3655681 tgctaaaatc atcagtgaga catttcgggc gaaacagcaa actcatgccg aagaactggc 3655741 agagccgttc accaaaagag agcttgaggt tcttcagcaa atggcctacg gactgagaaa 3655801 tgaggatatt gctgaaaagc ttttcgtcag tgaaagcact gtgaaaaccc acgtgcaccg 3655861 catcctgcaa aaatgcaatg cccaagaccg gacacaggca gtcgtttttg ccattcgaaa 3655921 cggtattgtg caatagaaat ctctcatccc gccatgctaa aataagacaa aggagatgat 3655981 tggaaatgaa agaagaaatc attgaacggt ttactacata tgtaaaagtc gatacacagt 3656041 ccgatgaatc cgttgacact tgtccttcca cacccggcca attgacatta ggaaacatgc 3656101 tagttgatga attgaagtcc atcggcatgc aggatgcagc cattgatgaa aacggctatg 3656161 tcatggcaac tcttccctcc aatactgaaa aagacgtgcc gacaatcggc tttctcgctc 3656221 acgtcgacac cgctacagac tttaccggca aaaatgtgaa tccgcaaatc atcgaaagct 3656281 atgatggaaa agacatcgtt cttaacgaac agctgcaggt caccctgtca cctgatcaat 3656341 tccctgagct gtccggctat aagggccata cactcatcac cacagacggc accacccttc 3656401 tcggcgcaga caataaggcc ggtatcgctg aaatcatgac agccatggat tacctcatca 3656461 aacaccctga aatcaagcac ggcacaatca gagtcgcctt tacgcctgat gaagaaatcg 3656521 gaagagggcc gcacaaattt gatgtgaaac ggttcaatgc atcctttgcc tacacggttg 3656581 acggcgggcc gctcggcgag cttgaatatg aaagcttcaa tgccgctgcc gcaaaaatta 3656641 cgattaaagg caacaacgta catcccggaa cagctaaagg aaaaatgatc aactctgcga 3656701 aaatcgcgat gaagctgaac agcctgctgc cggcagacga agcgcctgaa tatacggaag 3656761 gttatgaagg cttctaccac ctgctgtcga ttcaaggaga cgtagaggaa acaaagctcc 3656821 actacattat cagagacttt gacaaagaga atttccaaaa cagaaaagaa acaatgaagc 3656881 gtgccgttga agaacttcaa aacgaatacg ggcaagaccg gattctgctg gatatgaacg 3656941 accaatacta caacatgaga gagaaaattg aacctgtcat cgaaatcgtc aacattgcca 3657001 agcaagcgat ggaaaacctc ggcatcgaac cgaagatttc ccccatccgc ggcggaaccg 3657061 acggatcaca gctgtcctac atggggcttc cgacgccaaa catctttaca ggcggggaaa 3657121 acttccacgg caaatttgaa tacatctcag ttgacaacat ggtcaaagcc gtaaatgtca 3657181 tcgttgagat tgcaaagcag tttgaagcgc aagcataacg ccaaaagcca gtccaaaaaa 3657241 ggactggctt ttttgtgtga aaatgaaaca ttttaaacac gtcctccgta aaacaagtat 3657301 caacaaatga ggaggaaaaa caatgacaaa acatgcaatc gctgccaaga gtctcttgaa 3657361 aaaatggatc atttccaggc cgcttaacat gaaaaagaaa tccagcccat ttcaaaaaat 3657421 cagaaaaatg ttcaaacgct tcttcaaata aaacatcaaa tcccctaaat acaatccgta 3657481 ttcacccgta ccgcccaaat gctccgtaat ttgggttttt tgtgttcaat tccgcaaaat 3657541 agggtataaa ccaaacaagc aagaaaacag cacccaaaaa caggtaattc gaattacgta 3657601 aacttaggtt aaaagttata taaaggaatt tattttatcg tcgatagtaa ctatagaacc 3657661 aatcatcaac aagagcaaac agcgtaattc aagactattt tcaggtcatc aggtaatact 3657721 gttttagagg gacagtttct tgttatttat tgatttagaa ttttttgaat actttttggc 3657781 attttatccg tacaatagag agtaccaaaa ctttttttgg gaggtatgta atatgatcct 3657841 atttattatc atcgcattat gcggctatct tcttttttct ttcagcaagg acaatcgccg 3657901 caaaccgcaa aagacaagcc ctctgccagc agccgcacct catcacaaca acctaatcga 3657961 ccttgacgcc atccgccaaa aacgccggat gcatctttcc taattctata tttcaaacga 3658021 aaaggctgct gaatcacgca gccttttaaa attgttttga tttagagcct gaaacctttt 3658081 cgccacctat ccgtaatttc atacaaggca aacccaaagg agacttcagc aatgatcgag 3658141 ttatttatga aacaaaaaat gttctcattt aaagatgcat ttcacattta tgaccgggat 3658201 gaacaagaaa cattcaaggt ggaggggcgt tttttctcgt taggagactc attacaaatg 3658261 acagactcat ctgggaaaac gctcgtttcc atagaacaaa aactaatgtc tttattgccg 3658321 cgctatgaga tttcaattgg cgggaaaaca gtttgtgagg taacgaagaa agtaacgttt 3658381 tccaaaccga aatttgtgat ttccgggctt aactgggaaa tagatggtga tttatggagg 3658441 gatgaattcc aactgacgga cggggaaaat gtccggatgt cagtgagcaa aaagtggctc 3658501 agttggggtg attcctatca cttgcagatt gcatacgagg aagatgttct gatttgcact 3658561 gccatcgcta tcgtgcttga tatggtttta tataacgatg aagatgaaag tattttctaa 3658621 aaagcattga caattgatcc aaaagtaata atattaagat aattgaaatc tgaatatgaa 3658681 gttgtacctt atcaagagag gtggagggac tggccctatg atacccggca accgctgttt 3658741 caaacagaat ggtgctaaat ccttaagaac attgcgttct tgcagatgag gcggagattt 3658801 gatcgttcaa gctcttcctt acacaaagga agagcttttt acatgcttaa tatttcagaa 3658861 aagaggcgaa taacatggct caacaaacga atgttgcagg acaaaaaaca gaaaaacaac 3658921 gcaaagcacc tttccgcgcc gatcatgtcg gcagcttgct tcgttccgtt ccggtaaagg 3658981 aagcccggca aaaaaaagcg gctggtgaga tgacagcgga acagcttcgt gatatcgaaa 3659041 atcaagagat cacccgcatc gtggaaaaac aaaaagaaat cggtctcgat gtggtaacag 3659101 acggggaatt ccggcgttcc tggtggcatt atgacttcct ggaagggctt gacggtgtgg 3659161 aaccgttcat cccggctgag gggattcagt tccataacac aaaaacgaaa gcgcgcagca 3659221 tcaaagtgac gggaaaactc gattttacga gccacccagc gctcggtgat tatcaatttt 3659281 tacatgagat tgccggtaac gcgacgccaa aattgaccat tcccagtcca aatatgctgt 3659341 tttttggcga aaaggcggat aaagggattt atgacgatca agaggaatac tttcatgata 3659401 tggcccaagc gtacaaaaaa gcaatcaaag ccttctatga tgctggctgc cgttatctcc 3659461 agcttgatga tacgtcatgg tctctcttct ttgaggacaa aggcagagag gttgtccggg 3659521 cgctcggcgg tgatccagaa acattgccag ccatatttgc caaaacaatt aacgatgccg 3659581 tcgcagaccg gcctgacgat ttaacgatca caatgcacat ttgccgcggc aacttccgct 3659641 caacctgggc ggcatcagga gggtacgacg ctgtagcgga aacgattttg gacggcttaa 3659701 accttgacgg ccttttcttg gaatacgatg atgaccgctc cggaaacttt gatccgctcc 3659761 gttttgtgaa gcgcaaggat ctgcaaattg tgctcggctt gatcacatcg aaatacggcg 3659821 agcttgaaaa tcctgaggat gtgaaacgcc gtatcaatga agccgcgcgt tttgtcagct 3659881 tggaccagct atgcctgagc ccgcagtgcg gtttcgcctc tacagaagaa ggcaaccttc 3659941 tgacagagga gcagcaatgg gcaaagctgc gccatgtcat cgacattgcc aacgatgtgt 3660001 ggagataatc tatcattgac agaaatagaa aatgtgtgaa taatagatac tatcagaaaa 3660061 tttaataaaa aggttttcct tatcaagaga ggtggaggga ctggccctgc gatacccggc 3660121 aaccgctgtt taacagaatg gtgctaaatc ctttagagca atgattgctc ttgaagataa 3660181 ggttgagatt gtcacgcaag ctcttcctta tccaaaggaa gagctttttt atatttgaat 3660241 ggaaagaagg aatggacaac atgtcacaac aaacaacacc cgcagaacaa aaatcacttc 3660301 aaagaaaaaa accgccgttt cgcgcggatc aagtcggaag cctgctaaga tctgagcccg 3660361 tcaaaaaagc gcggctgcaa aaagcggccg gcgaaatgac cgctgagcag cttcgccaaa 3660421 ttgaaaacga cgaaatcatc cgcattgtgg aaaaacagaa ggaaaccggc ctgaacgtcg 3660481 tgacagacgg tgaattccgc agagcatggt ggcactttga tttcctggaa aacttagatg 3660541 gcgttgagcc gtttactcct gagcaaggca ttcaattcca taacgtacag acaaaagcac 3660601 gcggcattaa agtcacaggc gatatcgact tttcaactca cccaatgctt gaagattact 3660661 catttctcca tagcattgcc ggtgacgcga cgccaaagat gacgattcca agtccgaata 3660721 tgctgttttt ccgcggaaaa ctggaaaagg atgaatacaa aaacgattat caacttttcc 3660781 agcacgatgt atccaaagca tataaaaaag cgattcaagc gttttatgac agaggctgcc 3660841 gctacctcca gcttgatgat acagcgtggg ccgttttctt atcagaaaaa ggcttaaaac 3660901 aaatcgaagc gttcggaaca acgcctgacg agcttcgcca gctgtttgcg aaatccatta 3660961 acgacgcgat tgcagaccgc ccggatgact tgacggtaac catgcatatt tgccgcggca 3661021 acttccagtc cacttggaca gcggaaggcg gctatgacgc agcagccgaa accatttttg 3661081 acggcttgaa tcttgacgga cttttcttag agtatgatga ttcacgctca ggcggatttg 3661141 agccgctccg ttacgtaaaa cggtctgatc ttcagcttgt tcttggctta gtgacatcta 3661201 aattcggtga gcttgaaaat ccggatgacg tgaaacgccg tatcgaagaa gcgtcccgtt 3661261 atgtaagctt agaccagctt tgcctcagcc ctcaatgcgg attcgcttca actgaggaag 3661321 gcaacaagct gactgaagaa cagcaatggg cgaagctccg ccatgtggtt gagatcgcta 3661381 atgatgtttg gaaataagca aagaaaaaaa cacacttgat tccctagcgg agcaagtgtg 3661441 ttttttatgt cattgtgcgg tgtagccccc atcaaggacg acagcctgcc cagtgacgcc 3661501 cttcgccttc tcgcttgcca aaaacacggc ataatccgca atttccttga cggaaagcag 3661561 tcgcttttgc ggcacaagcg gaaaaatgac ttgttcaagt acagagtcgt aagggacatt 3661621 tctagttttc gatagatcgc taagctgatt gcgtacaagc tgggtatcga cataacccgg 3661681 acagagcgca ttgactgtta tgccgtgggg cgcgccttcc agcgccccta cttttgtgag 3661741 tccaatgacg ccgtgcttgg cgctattata agcggatttc cctgcaaagc ccactaatcc 3661801 attaacagac gcaatattaa tgattctgcc aaactgctgt tttttcatga tcggaaaaac 3661861 atgcttcatt gcaataaagg gagccgtcag catgaccttg atcagctgtt caaaggtgtc 3661921 tgtcggaaac tcttcaatcg gagcgacgtg ctgaataccg gcattgttca ccagaatatc 3661981 caagcggccg tattgttttt ggatgacgtt caccgtatca gcaacttgcg cttcctttgt 3662041 cacatcatac ggaatggccg ccgcgtcaaa gccttcttct gcaagcttgg aggctgcttt 3662101 ttcacatgct tccggacgga ggtctgaaac gatgacgctg gcaccttccc gggcgaattc 3662161 tcttgcgatt tcgaatccga ttccgccggc agcccctgtc accaaagcga cttgttttct 3662221 catgtcaaac accttcccat taagaattga gtacagactg gcttacagcg aaatcagctt 3662281 ctgttttttc ataaacctct tcaattgtga caccatcctg aagctccgtc agtgtcatgc 3662341 ggccgttcac aaaatcaaat acagccaaat ccgtaatcag cctgtgtacg actttctggc 3662401 ctgtcagcgg aagggagcat gtttttttca cctttgattc accatgctta ttgacgtgct 3662461 ccatgatgac aacgattcgt ttcgccccgt tgacgagatc catggcgccg cccatccctt 3662521 ttaccatttt gcccgggatc atccaattgg ccaaatcccc ctgctccgaa acctccattc 3662581 cgccgagaat agctaaatcg atatgcccgc ctcttatcat cgcgaatgac tcagcgctgt 3662641 caaaataaga ggcgcctgtc acttcagtga tcgtttcctt tcccgcattg atcaaatccg 3662701 cgtcttccgt tccttccaga ggataggggc caattccgag caagccgttt tccgactgaa 3662761 gcatgacgtg aacgccatcg ggtatctcat ttgcgacaag cgtcggcatt ccaatcccga 3662821 gattcacatt catgccgtcc ttgatttctt gtacagcccg tttgaccatt cgttttctcg 3662881 cttccttcac ttggcctcac cctttcccga tgcttgctga actgttcgtt tttcaatccg 3662941 tttttcttgg ctcgcgccaa gcacgacatg ctgtacgtaa attcccggcg tatggatgtg 3663001 atctggatcg agctctcctg cttccacgat ttcttccgcc tcggcaatcg tgatcttgcc 3663061 tgccatggcg gcaatgggat tgaaatttct cgccgttttc ctaaaaatca aattgcccat 3663121 ggtgtccgct ttccacgctt tgacgatcgc cacatcgccg gtaatgcctc gctccagcac 3663181 ataagtccgg ccgccgaatg ttttatgttc ttttccctcg gctatggagg tgccgacgcc 3663241 tgtcgccgta taaaatcccg gtatgcctgc accgcctgca cgaattctct cagcgagcgt 3663301 tccttgggga acaagctcta cctcaagctc tccgcttaaa aactgccgct caaaaatttt 3663361 attttcaccg acataggaag cgatcatttt cttgatttgc ttgttagcca gaagcaaacc 3663421 aagcccccag tcatcgactc cgcagttatt gctgacaacg gttaaatcct ttactccctg 3663481 atctcttata gacaaaatga gctgttcagg gatgccgcac agcccaaacc ctcccgcgat 3663541 cagcgtatcc ccatcatgaa tcagtttcgc agcttccttg cttgatgaca gcacttttcc 3663601 catattgatg cccctttcgt tttcttctac actagaccag tcaggctgta aatcgcgatc 3663661 acagcaaata cggcagccgt tttaatgagc gtgatcgcaa aaatatcgcg ataggattgc 3663721 cggtgggtca aacccgtcac ggccagaagc gtgataacgg cgccattatg cggcagtgta 3663781 tccatcccgc ctgatgccat tgaaatgacc cgatgcatca cctctggcgg aatattgtaa 3663841 gcctgaatcg cctgtaagta ttgttctgac atcgcgctta acgcaatgcc cattcctccc 3663901 gaagccgagc cggtgattcc cgccagcgca gttgtcgtaa cggcgccatt tacaagcgga 3663961 tcggtaaaag tatgtgaaat tccgctgctc agcttatgaa accccggcag cgcggcgata 3664021 atgccgccga acccgtactc agcacccgta ttcatagatg ccagcaaggc gccgccaatt 3664081 ccttcattca gcccttcctt caattgggca aacacacttc tccaatcaaa taatatcgtt 3664141 gtgatgatgc caatcactaa agcaatctcc accgaccaaa tagcagccgc tgaagaaata 3664201 tcaagcctgc cgaactcctt taatcctatg gaagaaaaat caaatccatt cggataccac 3664261 tttggcaggt aaatggtgaa atatttattc actgcaccga cgagaataag cgggacaaag 3664321 gcaagcgcgt gccgaatcgg gcttttgtcc ggttcagccg cggactcaat cgattcagga 3664381 gcaggagcat tctgcgaatc aaaaccgcca tagccttcgc cagatgcctg cgctttcttc 3664441 cgccttgatt ccaaatagag catcccagct gccagcacaa tcactgcgcc catcaaaccc 3664501 agccaagggg cggcataaat gtctgttttg aaaaacgacg tcgggatgac attttggatt 3664561 tgcggcgttc ccggaagtgc gtccatcgta aacgtaaaag ctcctaaagc aatcgtaccc 3664621 gggatgaggc gttttggtat gtttgcttct tggaacatgt ttttcgcaaa aggatataca 3664681 gcaaatacga caacaaacag gctgacaccg ctgtacgtca agacagcacc catcagcaca 3664741 atggcaagta tcgctctttt tgccccgaca agccggacaa ttgttttcgc gattgatgcc 3664801 gcaagcccgg ccatttcaac gacctttcca aaaatagcac cgagcaaaaa cactgggaaa 3664861 tacagcttaa taaaacccgc catcttctcc ataaaaattg atgaaaaaaa aggaagcaca 3664921 tggcttggat ctgtcagcag caccgcgaat aacgcgcaaa tcggcgcaaa caatatgaca 3664981 gaaaatcccc gatacgccgt aaacatcagc aaacctaacg ccaatagaat gatgatcagt 3665041 tccacacaca catcccccgt ttccgcgaac tagaaagcgt ttacaaaaac ctgtccgcat 3665101 cggctgtttc cgtccccttt ccatatgtac gagaagcgtg ggccaactat tccgattaaa 3665161 aaaggaaagc tccttttttc ggagctttcc tctaccattc atttcattcc tattaggata 3665221 tcaacatcaa ccgtaatatc ggctgatttc atctctttca gcaggctgac tcgatctttc 3665281 ggcgccgacc aggcaagcgg cgtcatcttg agaagccagt ggatcgcctg ctggtcaagc 3665341 gttttaacat agcgcagcct gacaggacgg ctgtgtgctg catttgctgt aaaacgctca 3665401 actgctgccg tattggaata cgtgcgcctt ggtgaatcag tatataaaaa ttgccttaat 3665461 tctattaaat agtcgcttcg cggcactact tttatgagca tgccatcatt cttcagcagt 3665521 ctatgaaact ctgcataatt ggacggcgaa aaaatagaca gaacaacatc aaattggcga 3665581 tcatgaaaag gagcacgcgc cacatcggca accgcccaca tcagatcttt gaatgcctta 3665641 gaagctttta agatcccgtc cttcgaaaga tctatgccgg ttcctatcgc tgctttccct 3665701 gcataatcaa acccgcaaag cgcattcaaa tgagaaccct caccgcaacc gctgtccaag 3665761 atggtgaatg cctcatgacc agatttggga tgactgatga gctctgcaat cgcatcatgg 3665821 agcgggtcaa aaaaaccaca ttctccaatc agcctgctcc tcgcttcaaa aagctcggca 3665881 ccgtaactgg ttttgaccgg cttcgtcaga aagttcacgt agccgtgccg agatagatca 3665941 aatgtatgtc ctcgttctgt acaaatcaag cttttccctg atgccgcatc catagaagaa 3666001 tcgcagagcg ggcatcgaaa catgctgaaa tcaactgttc gcttcatgat aaaaaacacc 3666061 ccattcattc atttttagat aaatgaaaaa ggcatagaca aataaaccta ggcctatctc 3666121 aaaaattggc caggtctggc agtttgtcta cacctgtcat tatctataac gaatgaattg 3666181 gataatcatg aaaaaaactc cctttctgct gtatgggttt ccccgtttcc atcatacaac 3666241 aaatatccag gagctggaac cttatagtga agaaaaatca gtactgacat gctggtatcc 3666301 cgccaacatc atatcagcat agcaatccag catgtttttc ctttattttc tcattttaga 3666361 atataaattt tattattgtg aaaatagtta aaaaggttga ttttcaaaaa gtgaaaggat 3666421 aaaatactgc tatcatctta gaaaaagaca ttcttgtata tgatcagtaa tatggtctga 3666481 ttgtttctac ctagtaaccg taaaaaacta gactacaaga aagtttgaat aaatttgaac 3666541 gagttgaaaa ggacaagttc ttttctgttt gctcttattt ttcacacttt ctgcacttcc 3666601 agaatttgtg aaggataaga gctttttttg tttccataat aaccctcata ggagttgcta 3666661 tcatgtactt tttactaaac cttgtcggtc tcattgtgat tatggcagtt gtattcctat 3666721 gttctccgca gaaaaagaaa atcaagtggc gcccgatcat tacgttaatt gttctggaat 3666781 tgctgattac ttggtttatg ctgggaacaa aagtcggaag ctgggccatc ggtaaaatcg 3666841 gtgatttctt cacttggctg attgcttgcg ccagtgacgg tatcgcgttt gcctttccgt 3666901 cagtgatggc gaatgaaaca gtagactttt tctttagtgc gcttcttcca attatcttta 3666961 tcgtcacatt ctttgatatt ttaacgtatt tcggcatttt gccttggctg attgataaaa 3667021 tcggatgggt gatttcaaag gcttcccgct tgccgaaatt agaaagcttt ttctctattc 3667081 aaatgatgtt ccttggaaat accgaagcac ttgcggtcat ccgccagcag cttacggttt 3667141 taagcaacaa ccgcctgctc acattcggtt taatgagcat gagcagcatc agcggctcca 3667201 ttatcggatc ttatctttca atggtgcctg cgacatacgt gtttacagcc attcctttga 3667261 actgcttaaa cgcgctgatt atcgcaaacc tgctgaatcc tgttcacgtg ccggaggatg 3667321 aagatatcat ctatacaccg cctaaagaag agaagaaaga ctttttctct acgatttcta 3667381 acagtatgct tgtcggcatg aacatggtta tcgttatttt ggcaatggtg atcggatatg 3667441 tcgcattaac gtcagcagtt aatggcattc ttggcgtttt cgtacatggc ctgaccatcc 3667501 agacaatttt tgcttatctg ttcagtccgt tcgcattcct gcttggactg ccagtgcacg 3667561 atgcgatgta tgttgctcag ctgatgggca tgaaattagc aacgaacgag tttgttgcga 3667621 tgcttgactt gaaaaacaat ctcaaatccc ttccgcctca caccgttgcg gtggcgacga 3667681 cattcctgac gtcctttgca aacttcagta ctgtcggcat gatttacggc acgtacaatt 3667741 cgatccttga cggagaaaag tcaacggtca tcgggagaaa cgtgtggaaa ctgctcgtca 3667801 gcggaattgc ggtatcttta ttaagtgctg cgattgtcgg cctgtttgtg tggtagaaac 3667861 attgagccat atcccttttc ggatatggct cttttcatta ttgataaata gaggctggca 3667921 cctgcacatc ccggattccc gctgcataag gccccaagtc atactggccg aagacgatgg 3667981 cgatcccgtt tgccgtaaag taaaacattg tgtctctgtt tagggttata tcctctttct 3668041 ttacatcaga gaaaaacagc acatcgtgtt ttttgatata gctatatagg taatctctcg 3668101 ttttgctgac ttttgttttg gtgttcagaa tctgatccag cgtcacccgc ttttgtgctt 3668161 tcaagtcata gttgaaggac tggacagacg ttagaccgtg ggcgccccct gaatagatat 3668221 aattgagtgt ttgaatgctg agcttgcctg ccgcattgta tttgacgctg aaggatgttt 3668281 gatattcccg ttttaaagcc ctgctgttcg cctgcttttt tgtttttcag gtattcctga 3668341 tacgattgtt catgtaggct ttcagctctt gattgatttt cttttcaaac gcggcattcc 3668401 cgacgtgatg cacttgtgga tacgttaact ccttgatctt tttgtacgta tgggtgctga 3668461 cagtcggtgt tttcgcttga actgctttta aagatggggc cgcatatgca aatacagaaa 3668521 aaagcaagac tgcaatgccc gcggctttca gcatgttatt ccatttcata caatctactc 3668581 ctttgatgtc gttgtttatc attcccttat ttaagcaata cacactttta tagactgatt 3668641 aaatcgaaag aagtttctag gtctaacagc atgatttttc caataaaaaa agagacacag 3668701 gatgtctctt tttttactgt ttgcgcccag aaatcgcttc atgaagggct tgtgccaaat 3668761 ctgtatttcc gaacatctct aataccgcaa tgacagtctg gtccggaatg tgctctgctt 3668821 cgtgttttgg cacgaccaga tcgtccatgg tttttttcaa gctttcattc agcttttgct 3668881 gcggatacgc tttggcgtac agctccatcg gatcaagatc atggttcacg caccactggg 3668941 caaacaccaa aatcatcata ttttcatcgc gttcgtaagc ttcagtgagc tgtttttcgt 3669001 tcatttgtca tgctccttat gaaaagtatc ttccttaaag atacaggagc cgatcaaatt 3669061 cgtctatccc aatggcgatg agcagcaacc gcatcgataa atgccttgct gaaagcggtg 3669121 tagtcaggtt catctttagc cgttacgatg cctagcccct ctgttgtccc gacagaggat 3669181 tgaagaaggt caattccttc atttgccgca ccgatcgcct tgtagtgatt gtaagcttct 3669241 ctgataaacg ccatcgcttg tttgttgtct tttaactcca gtcctcctgc ggcatagacg 3669301 gcatcataca gaacagaatc aaccgtcagg aacgtgccgc tggcctcaag ctgctgtccg 3669361 ctgccgcttg tcatataccc cagattttga ctgatgatat ccactgtgat tccttcttgc 3669421 tttaaggctt ccagtactgt ttgcagctct ttttcatgaa atccgtttcc ggcgagtaca 3669481 gcgacttttc ttgttgacgc ggttttcact gtacgggctt ggcttaacgc aggcgaagta 3669541 agaatttctt tagatgcttt acgcttcgcg ggcgccgcca cgcctactcc tttggcgatt 3669601 tcttctgcta aatctgcatc gacattgctg aagacatcaa cgacctgccg ctgtacgtct 3669661 ttgcttttga ccttcccgac ctcgaagcag aaagcagaaa tgatgtgctg tttctccaca 3669721 ggagacatgc tgttccagaa aagcttcgcc tgtgagtaat aatcgttgaa gctgtcgctt 3669781 cgctggcgga tttttttgcc ctcgactttt tcctgatagt ggacgtagcc gccttcttca 3669841 gctgtcgcag gcgacggatc attgttttgc agtgagtttt tatgataagc gacaggtccc 3669901 ttattgatcg tcatccggtg atagccgtcg tattggttgt tatggaatgg acagaccggc 3669961 cggttaatcg gaatctcatg gaagttcggg ccgccaagac ggatgagctg tgtatccgta 3670021 taagagaaaa gccgcccctg caatagcggg tcattggtaa aatcgatgcc cggcacgaca 3670081 tttcccgggt ggaatgcgac ttgttctgtt tccgcaaaca cattatcctg attgcggttc 3670141 agcgtcattt ttccaatgat cttcaccggc acaagctctt ccggccacag cttagttggg 3670201 tcaagaatat caaaatcaaa cttgaattca tcttcctcat caatcatctg cacgccgagc 3670261 tcgtattcaa ccttgccgcc gttttcaatt gtttcccaca ggtcacggcg gtggaaatct 3670321 ggatctttcc cggcaatttt ttgcgcttca tcccatacga gagaatgcac gccgagcacc 3670381 ggcttccagt gaaatttcac gaaacgtgcc tttccttgtt cattgacaaa acggaacgtg 3670441 tgaacgccga agccttccat cattctgtag ctgcgcggga tgcctctgtc agacatcgtc 3670501 cacatcacca tgtgggcaga ctcagggtta ttggcgacaa aatcccaaaa tgtatcgtga 3670561 gcagtcgcag cctgaggcat ttcattgtgt ggctcaggct taaacgcgtg aaccaaatcc 3670621 ggaaatttga ttgcgtcctg aatgaaaaac accggaatgt tatttcccac aaggtcatag 3670681 tttccttctt cagtataaaa ttttgtcgca aagcctctgg catcccgcac cgtgtctgcg 3670741 gagcctttag aacccgcaac cgtagaaaaa cggacaaata ccggtgtctt caccgaaggg 3670801 tcctgaagaa atttggcccg tgtgtattcc gtcattggtt cgtaaacctg aaaaaagcca 3670861 tgcacgccaa atccgcgcgc atgcacaacg cgctccggaa tcctctcatg gtcaaagtgc 3670921 gtcattttct cccggaaatg aaaatcctcc atcagcgtcg ggccgcgaac cccggctttt 3670981 aacgagtgct catcctctga cactcgcaag ccttggtttg tcgtcatttt cttcccgctg 3671041 ttatcggtcc tgtactgctc aagctgctcg tcctttgagt gttcatttac acgtttgttt 3671101 tggtcatcac tcatgtctgc tccccctttt taaaacgaaa cattctacag cacatttacc 3671161 cgtggcgttc ttcatataaa ctgctaatcc gctcattagg atttttggtc tacatataaa 3671221 tatgcggtca tacacatttg aaataagcct tcttcacaga aagaaaggat ggaagcgctt 3671281 accaaaaaag ctgttgaata ggggaggtca tatcatgctt gccatactcg gttttgtgat 3671341 gatgattgtc tttatgtacc ttattatgtc taaccggctt tccgctctta ttgctttgat 3671401 tgtcgttcct attgtgtttg ccctgatcag cggatttggc aaagatctcg gcgagatgat 3671461 gattcagggc gttacagacc tcgcccctac cggtatcatg ctgttattcg ccatcctgta 3671521 tttcggcatt atgattgact caggcctgtt tgatcctctc attgccaaaa tcttatcgtt 3671581 tgtcaaagga gatccgttaa aaatcgccgt aggcacagcg gttctgacca tgaccatttc 3671641 gctggacgga gatgggacaa caacctatat gattaccatt gcagcgatgc tgcctctcta 3671701 caaacggctc ggcatgaacc gtttggtgtt agcgggaata gcgatgcttg gttcgggggt 3671761 tatgaatatt atcccgtggg gcgggccgac tgcgagggtt ttggcttcct taaaattgga 3671821 cacgtcagag gtctttacac cgctgattcc cgctatgatc gccggcattc tctgggtgat 3671881 cgccgttgct tatatcctcg gaaagaaaga gcggaagcgg ctcggcgtca tttcgattga 3671941 tcacgcaccg tcttccgacc cggaggccgc accgctcaag cgtcccgctc ttcaatggtt 3672001 taacctgctg ctgactgtcg ctctgatggc cgcactgatc accagcctgc tgccgctccc 3672061 tgttcttttt atgactgcgt tcgccgttgc cttgatggtt aactatccaa atgtcaaaga 3672121 gcagcagaaa cgaatctcgg cgcatgcggg taatgcgtta aacgttgtct caatggtgtt 3672181 tgctgcgggc atattcacag gcattctctc cggcacaaaa atggtggatg ccatggcgca 3672241 ttctctcgtt tcactcatcc ctgatgccat gggcccgcac ctgccgttga tcactgcgat 3672301 cgtcagcatg cccttcacct ttttcatgtc gaatgacgcc ttttacttcg gtgtccttcc 3672361 catcatcgcc gaagccgctt ccgcttacgg aatagacgcc gctgaaatcg ggagggcctc 3672421 cttgctgggg cagcctgtgc atctgctcag cccgcttgtg ccttccacct atctattggt 3672481 aggaatggca ggcgtcagct ttggcgacca tcaaaaattc actattaaat gggccgtggg 3672541 aacaacgatt gtgatgacca ttgcggcgct tttgattggg attatttctt tctaaatgta 3672601 tgagcttgat cgtagcattg agtgagtacg tgatttacag aggggagaag atcaaatagg 3672661 atattatgag tgaatagaag attcatgcca acaacttctc attacaatca taagagcctg 3672721 ctatattgca gcaggctctt tcacatttgg cattattttt ttgtatagcg cacccagtca 3672781 taatgagcgt atagcggatt tacaccattg taggagccaa gccattcatc gacacccgtg 3672841 ccattccaca agttcatcat gatctttcca ggtgttgtcg gaatttggtt tgttgcagta 3672901 tgttttaatt gcccgtcgac ataccattta atagagtttg gctgccaatc gaatgcatac 3672961 gtatgatagg cattggctgc atcaaacccg agatcaacaa tcttctcatg gtttcctgca 3673021 ccatttgtat aatagttaaa ttgaaccttc gttgtgtctt ttcctaaaaa ttcgatatca 3673081 atctcatccc aaggagttcc atctgttgga cctgtgtaag tgaagaacga tgaaacgatc 3673141 cctgtgtttt tagctggttt cattctgact tcataaagtc catagccata tgtttgaaca 3673201 gaacggtttt ccccgcagtc aaacttgtta taagctgggc ttgttagcgc taaacgcatt 3673261 tcacccaatg acgtcattga tacgttatta gcccgccacg tgcagttgaa catatttcca 3673321 ttcgaataac catctgcttt ttgccaaaaa ccggagttat agccgttaaa agggtcaaaa 3673381 aacgatccac ctgtttgagc tgaggcagta gcagtgactg caaacaaact cataaacaat 3673441 ccagtgacaa gaagcagcaa cactcgtttc agataaggca tattggcatt cccctttcat 3673501 tgaaagcgtt ttctatgttg atcttacatg attcttttaa aagggaacat cggtcaaaat 3673561 aatgataata tcgaatctta ctaacttgaa tcctgtaact atcatcatct tccctctgaa 3673621 aaaaataaaa acctaaatta ccatcagcac agacagagat gatccgcact cattgcaatt 3673681 taggttttgc ctgctttatc agtaacaatc ctaccatttt catatgtgaa tgtaagaaaa 3673741 agtgaacaca aggaaacaca aatgtcagcg ctctcattat gcttgtttaa ctaccctttc 3673801 tatgtgaatg gttaaataca gcagctcgtc acttgtgagc ttgtgctcat actcccgctc 3673861 aatgtaggtt tggattttct tcgtgcattc atacgcgcga tgatactttt ctttcactgt 3673921 atccagcaaa aaatcgtcct ggctttccat gtgagtgccg ttaaatagac gctgcgcgaa 3673981 aaactttaag tgggtgacga accgataata gtgaagcgat tcttcgttga attcaatctt 3674041 aaaatggtat tttacaatac tcaaaatctc ttgcatgact tttgtaatgt tgataatatt 3674101 gggcatctct tcattcagct cggcatttac aatatgcaga gcaataaagc ctgcttcatc 3674161 ctctggcaga gacacaccag tcttgttttt taccataacc aacgcttctt tgccgatcgc 3674221 aaattcgtct ttgtagagcc gttttgtttc ccacagcaag gcgtttttga tatcaagccc 3674281 tttctggttg cgctggatgg caaagttaat atggtcggtc agcgacacat agatgctgtc 3674341 gttgagcttt ttgccgagct gtaattttgc gtagctgata atctcttcgg atacttccat 3674401 acactcgatc ggtatatcat acaaaagggt tttgaacttt tctgatacat ccttgttatc 3674461 gagcgtgaac actttctcaa tgcgggcttc atcgacatca tcgccggact ttttctgaaa 3674521 cgcgagcccc ctgcccatga cgaccaattc tttcccctgt tcattgacca cgctgatcac 3674581 attattgttg atcaccttcg caattttcat ggcatgtccc tccaaatcta ctaagaacag 3674641 actatatctt gattgtacat tctttttgta ctaggtcaat atcatcaggg aaagacggaa 3674701 gctggtcagt acaattcact ccgtacctgc tgcccgggct gtttttgaag cagcgcctcc 3674761 agatggcgtt caaatgatgc cttgtcagct ttctgctttt tgacaatgct gttcatgatt 3674821 ttaatgcttt cagcactgta ttgtgtatat tgttttttca gctgatccag ctgctgtctt 3674881 gtcttcttcg cgtttttcgg tgtgacttgg ttgatgagtt tgatcatact gtctgcggtc 3674941 tcaaaaaaac cggctctatt ttctgtcagc tgctgaattt cgatgcggct catatcttga 3675001 ttacgcgttt tttgaagcaa ggcaaccgcc tcgctgtttt gttttttgag cgatttgttc 3675061 tcaagcttaa tcgattcgag attctccttc gcaatgtctg cttcttcttc agtcatgctg 3675121 attcgcacga agtattctgg attgccgatt ccataatcaa atgcttcgct cacttgtatc 3675181 atggaactga acacaatggc cagctgcctg tcgcttgcga gggcttggaa atcctgcttt 3675241 ttcttactgc tcatcggttt ggctgcggtt tgttttactg tcttttgatc acagtctgcg 3675301 aacatctgag cctcaccttc actttcgcat gcgctcatca caagaactgt gaccagcagg 3675361 cttatacaca agcctattcg cctcatgctc tgtctcctct ctgctgaatc ccttctggaa 3675421 aataccataa aatatagtta aatggtacca gatgcaccta accccagcaa taaatcaaaa 3675481 gtatgatttg aagcgaaaaa acataaatat tttgtaaaaa ttgacgtgca ttccattctt 3675541 ttcaggccca tttctcgtac aatagaagta tcgttaccgg agaggggctc tgatgatgaa 3675601 acgttttacg aaacaagaaa acagctgggt gttatatgac tgggcaaatt cagcttactc 3675661 aattgtcgtg accaccgcgg tatttccgtt attttataaa tcagcagctg cggaaagcgg 3675721 tgtcagcgcc gctcaatcga ctgcctatct gggctatacc attgcgattt caacgtttat 3675781 tcttgcgatg ctcggcccta ttttaggcac aatcgccgac tatgaagggt gcaagaaaaa 3675841 gttcttcggt ttctttgtgt cagccggtgt cgccagcacc gcgatgctcg cctttatccc 3675901 tagtgaacat tggctgctat tgttgctgtt ttatacggta tcggctatcg gtttttccgg 3675961 cgccaatgtg ttttatgatg cctttctcgt ggacgtcacg cctgagaagc ggatgaatct 3676021 cgtctcggca cggggttttg gcttaggata cattggaagc acgattccat ttatcatcag 3676081 tattgctgtc atcctgctcg cacaagcaga gactattcca gtgtctgtat cggccgcaag 3676141 ccagctgtcc ttcttcataa cggctgcctg gtgggggctg ttcaccatcc caatgattaa 3676201 acatgtccat caacgctatt acatcaaaaa agaacctcat attgtcatca acagctttaa 3676261 gcggctcggc caaacgatga aacggatcag gcaataccgg gcacttttcc tcttcttgct 3676321 cgcttatttc ttttatatcg acggagtcgg cacgattatt acgatgtcga catcctatgg 3676381 atcagattta gggatcggct cctcaagcct tctgatcatc ctatttgtca cccaggtagt 3676441 cgccgcgccg ttttcgatta tatacggaaa actggcagaa cgcttcacgg ggaagaccat 3676501 gctgtacgtc gggatcgtca tttatatgat cgtctgcgtg tatgcctatt ttatggagac 3676561 aacgcttgat ttctggatac tggctatgct tgtcgccacc tcgcaaggcg gtattcaagc 3676621 cctaagccgt tcctatttcg ccaagcttgt gccaaagcgc cacgccaatg aattctttgg 3676681 cttctacaac atttttggaa aattcgcctc aattatgggg ccgctgctca ttgccgttac 3676741 cgcccagctg accggtaaat cctcgactgc ggtgttcagc ctgatcattt tgtttgtgat 3676801 tggtattgtg attcttgcct ttgttcccga ggaaaccagc acagatgtca gccagcagca 3676861 aaatgacctg cccctttaac tgggagcagg tcattcatca tttattcgct ttattcacct 3676921 tcagctgttt ccctttgacg gttgtgttct tcatcacttt gagaacatga gggcctttac 3676981 catttaaaat ctcaacgtat gaggcgttat ccatgatcgt gatgatgccg atgtcgtcag 3677041 ctgacacacc gtcaattttg gcaatcgttc ctacaaaatc aacggctctg attttctttt 3677101 tctttccgcc gttaaaatac agcttcataa tgtctttatt cagctcttcg cttttgtcct 3677161 ttttgctttc cggacggtca ttcagtttag ctagaaattc tggtttcttc cttgccactt 3677221 cctcttgaga aggtgcttct attttttgga tttcaaatcc gatatattct tcaatgtcgg 3677281 ctaaaaaccg tttttcgaag gccgtgacaa acgaaatggc ctttcctttg ttccctgcgc 3677341 gtcccgttcg gcccgtgcgg tggacatagc tttctttttc aagcggcaga tcatagttga 3677401 tgacaaggga gatattttca atatcaatcc cgcgcgcggc gacatccgtc gccactaagt 3677461 aacggtactc gccacgttta aattcattca tgacgtcgaa tcggtcttcc tgaatcattc 3677521 cgccgtgaat tttatcgcat ggatatccca agtcatccaa ttcatcggtc agctgattga 3677581 cgtgctcctt cgttcggcag aaaatgatgc agctgtcggg attctccgtc atcagcacat 3677641 ctttcagcaa tgaaaactta ttctcttctc ttacttgaat caccgcatgt tcaatatttc 3677701 ttgtggttag gccggccgct ttgacctcga tatgctcggg gttttgcata tattgacggc 3677761 tcagcttctc gatatcctgc ggaagcgtcg ctgaaaacag catcgtcgta cgctcagtcg 3677821 gcagatgctt gataatcgcc tccacctgct caatgaagcc catattcagc atctcatccg 3677881 cttcatcaat gaccaaataa gagagacgat ccaacggcag cgtgcctttt tcgatatgat 3677941 ccagaacacg tcccggcgtg ccgacaacaa tgtggctttt ttgcttaagc tcagcttttt 3678001 gtttatcaaa ggaggatttt ccaaatacgg ctgtcgcttt gatccgttta aatcgtccga 3678061 tgttcgtgat atcttccttt acttgcaccg caagctcacg ggtcggtgtt aaaataagcg 3678121 cctgcggctt gttttcatcc caattcgcca gctcacagag aggaatcccg aacgaagccg 3678181 ttttcccgct tcctgtctgt gatttgacga caagatcctt tcgttcaagg gcagcgggga 3678241 tcacactctg ctgcaccttg gtcggttctg tatatcccag tccttccaat gctcgtaaaa 3678301 tgtcatgact gatttgatag tttttaaaat gactcatgta taaactcctg tctcttgcag 3678361 atgttctcat tatactctaa ttgaccaagg catatgtgtt ttgtcgaaaa atgatgtatt 3678421 aaaagccagc gattccctgg cgttttagct cctgaacagc caatcgcgcc agtgcgtcgg 3678481 cccccgcgcg attcgggtgc agcgtatctc catccatata aagcccgagt gttctttccg 3678541 gaccgatcga tgtaaagtat gccgagctga ggacatttaa gtcaatgaga tatgtttttt 3678601 cctcttcggc caaagctaaa atagaggccc tgtaccatct gtttacagac gaatggatgc 3678661 cttcagaagt aaaatcggtt gcccggccct gaggcgttga taggatgacg tccgctcctt 3678721 tcgcttttac ctgacgaatc atatcacgca tcacctcttt aaactccgct tcagattctt 3678781 tatgcttcgg atttgtgtca ttaatgccaa gctgcaacat aaaataatct ccgggtttaa 3678841 tatacttcag aatcgcctca agctgtccat catttctgaa ccctctcgcg atctgcccgc 3678901 cagacgccat gtttctcact tgaaaggtgt gtttatcgat atagtgaggc agcatctgcc 3678961 cccagcccgc ctgcttgctg ctgttgagcg gataataatt gcacaccgtc gagtcgccgc 3679021 cgacataaat ggttcgattc gttaccggct gatcagacaa tttctttatt ttcaaggcgc 3679081 tgagcgtaaa agcggtgcct gcctttccct ctgtcaccag cagattcagc tgcccgtcgg 3679141 tgacgggaat ttggaacgta tcctccgcgc catcccctgt catattgatg acctgaaaca 3679201 cgccctccgc tgccacactg gcccttgccg tattgccaag cgtcaccttc acctcataaa 3679261 ggccattcgg gagatcaaca ttaaacgtgt tattgctttt cgtcccatac gctaaaaact 3679321 gaaccgcatc actcttcaca ccagccccgg atgccgccac atccctcata ttctccggtg 3679381 tttgaaaacc gtagcccttt gaccggtcat accgatcaga cgccctgaca ccaatataac 3679441 caggctccat cgaaccgctt ccaaagtcaa actgatacac cttcggctcc gccgccttca 3679501 cattctcaat cccgccaaaa cacagcatca gcatcatcac aaaaaccgct gccatccatt 3679561 ttttcatcaa gactccccct ctatgaaaac gaatacatta atgcatactc ggtgattgtt 3679621 tctttatgat gactgaatta agaaaaaaat tgcgttgagg aataaaaatg aggggagagt 3679681 ctcaagaagg ggaaaatcag tgtgacttct tgtcacactt gatcacatcc caacctccgc 3679741 aatagaagct tatttggttt tcttcgtcat acacataata acggagtctt tcccattgat 3679801 cgtcagtcgg tacaatctcc aatgcaaccg aatcgatgga ttcaaggtca tccagctttg 3679861 atgcactaat gttttcaaac cgcaattgaa tgtcacaggt ttgagcagat cgttttcatt 3679921 caaacacagg aatatgaata taacgatcat cttctttcat atagaaagaa aactcgttta 3679981 atgtaaatgg acctgtatcc tcatcagaaa gatgctgttt caatttctcg tattgtgtga 3680041 tattcaaatg aattccctct atttatatga ttcaccgcca atcatataaa tgtccacagc 3680101 atcgtattca aaccatatga tccgttcgcc tgagtccgtt aggcattgga gcttcccttc 3680161 tgaaaaatag cttttatccg gttgaggatc agtgatcaga aaaacatcat cattgatgga 3680221 agctagcaga aagagaaaat ctgcaatatc ccggtctgct tcctgtaata tggattggaa 3680281 atggaattcc cttttggcca gcttcgtcac cttgtaagca tgaccttcaa aatactcgga 3680341 caggtcttct ataaatgaac cagtcgttat tacctgtatc atgattcgat cgtaggcaag 3680401 ccctgcccaa aaacgataaa acgactctgc atcttcaagt tcgcatgcca taacggtttg 3680461 gtcaggctta agctcgatca tgtccaaatt gccaatactg cttatagagg ttatttccat 3680521 aaaatcttcc ccttatcagt tggatagcgc aacgcaaatc tcttgtctga cttgttcata 3680581 caagagaatg tgatgataca gatccttatc gtttttgatc atatccggaa gtatgtcagg 3680641 atacagctca aaaaagcttt tctccaacga acgccgctga tgccggggta tccttttatt 3680701 cgccagcaca taatccaaac tgccagcaac aagcataaaa aactcataga tttccgcttc 3680761 aaagccgtac aattcatcag ggtactgctt ttcttcaagc tctcgctgtc tttttctcag 3680821 tttttgaagc acgttgatcc tctcccttcc gcaataatct catttatttc gaaacagaat 3680881 aggcggatca ttatctatcg cctccaacag ctcttcacca aacacagtga ttgcacattt 3680941 ccacgggtct cccaaaagtc cccaggagaa gtcctgatga aaaaagaaat aatagtctcc 3681001 atttggaaat acgggaacag gccattcgcc aaattcatcc ttaggcattg cctgatgagg 3681061 actaaaggta tatccgtcat gctgccaatc tagtgcgtac attacatcgt tctttccagt 3681121 acctaattga aatgctttta aaatagaagt ctctaaatca cttagcactc cgctcacatc 3681181 attatgacca gctttactgc tcatcgcgct tgagatatca aacactcgat atggatcagg 3681241 cgggatgatg tgatgacatc tgcttccggg cttccatttt atgatcttgt tcacttctga 3681301 ccagatgcgg tcttgttttg tctgacttaa agcgcgccaa ttcatcataa tctcatccct 3681361 acaccttatt ggatatcctg cttataaaca ccagaagagg ccactgcgta aacagcgtaa 3681421 cttgtcagtt tcagctgttg aacatctagg ccttcaccgt tcgaatcaca gcatgttatc 3681481 tcttccatct cttgactcac atcggcagaa atcaaataaa gagacgactt aaggtctgca 3681541 ctgtaacaat tgaacgtccc aaccaaaaaa ccttcttcgg atatcgcgag ctgatcaaat 3681601 gcttctgagt ccggctcttt atccgacaga atccacaccc gtctcacgac cgtttcatca 3681661 aatgcggcaa tgactgcatc tccgtaatac agcatataaa tcaagccgtt tttttctgca 3681721 agtccataac aatcatctac agcaggcgca tccatttctt caagctttct atcaatgtgt 3681781 atttccttct gctgaccatc taacgtaaaa caccacacac tatggccgtt gggattctca 3681841 tcatgataaa tcccttcatc acataaaccg acccaaagct gttgtttcta atccaaaaga 3681901 cagcaggaaa cccctgaagg caagtgaaaa acacttttca cccttccctc ttctgaaaaa 3681961 acctttacct tcggctcgta cgattcgtaa taaacgaaga catagccatc tgcacattgt 3682021 tgaaagagca gaatatcact gtatgaaatc tgctctttca ctctaaaatc ccgaacatca 3682081 ccggaaggat catagattgt aatggtgata ccacctttca acccttttcc aatgtagaca 3682141 cgcccctgtg gatcagcatg gaaaaaacaa tcttgggtgt tctcgttgat gattttattc 3682201 aattttaatt ttttcattgg ttatgctcct aggttcgaaa tgaaatgata agaataaacc 3682261 atttattagc tattagtaac ggacaaccta gtttcattaa tcgttttggg ataaatctac 3682321 tttccaattc agccttaaat catttagtgt ttaattggta tgcataaaac gattgatcat 3682381 caaagcgaac tgtttcagct tctatagcaa tcagcattct gttcatgtca ataagaaagt 3682441 tagcatttga ttgatactcc ggaattatag aatttgatag attcccgatt ccttctggat 3682501 gataactcat ctcaaatact tgccaattgt attcttccgg atctattttt tccaatctca 3682561 tgtcgccaac atctgcacta taataagcgg atgccacatt ttgaaatgaa attttatgcg 3682621 tatattcacc ttcatcttca aaaaccttaa tatcaagtga gagttctttt ttaaacacat 3682681 taaaatctaa atgaaggaca ctgcacccct tatctatata atcaacccat tcattaatcg 3682741 tttgatacat tgtcatcccc tgcctctttt taaacaataa cgccttgcca ccaagcagaa 3682801 aacaaattac tccgtatatt gtttgatcca atcatttaaa tcatctgttg aatgcaaata 3682861 agtttctgat gaatctttca aatcaatccc acttagaagg attaacatat cccagactct 3682921 atcgtcttct acttcggggt catccgcata aacataagtt ccagcccaat ccgacacttc 3682981 ttctcttgtt gtttgtccat ttaagacact tttgatttta tttatgcatt ctattagatt 3683041 tgtctcgctc aatttgatca ccacgtattc aagtactaaa tgatttttta ttagtatgca 3683101 aagcaccgta ctgatattta gatattgaag ctttttccgt aaaagatatg ttccaaaagg 3683161 tttccaatct accaataaac aagctcacat ccgtattccg tgtgcaatat acataaacca 3683221 aactggcact taggctcaac caaaataaaa ctatgattga gaatcccttc atcgaactca 3683281 atacactcca ataagcagtc aaggtgctcg agacattttc caaaagaaca aactaacgca 3683341 ccaatttcgc tgctgtattg atgaaacagc agaacgtccc ggtcatcgta agcaacatat 3683401 gactgagata ttttccagat cagctgtttc gcttccgttt tttcgagggc atcaacctca 3683461 cgggtgttgg ctggtattga atttgataaa accagctcaa gcaattgcct gctttgcgcc 3683521 agatcagcaa aacgataagt gaagcctctt tctgcacaag ggactagttt ttctttgatt 3683581 tcgctcatca ataaacgtct tttattctcg gcgagttttt cgatcaatct tttttgcatg 3683641 agccgcattc cctccgctgt caatttctca acttctttta aattgattca tcattctctt 3683701 gttttcgttg tcgttcatgt ttagatttgt tctaaaaaag cttgtatcgc ttatcgatac 3683761 aagctttatc ttcaactgct taaaactcac ccagtgggct tttcacaaaa cgctgggaac 3683821 ctttttggca aatcctcttc atcccaatca attctatatt tttagattct tttgtcatac 3683881 aaataagaga ggatggtaac atctcttatt taatgttcca tcaataaatg ccccattttt 3683941 atccaatgca gaaattattt ataattaagg aagtttagaa ggattttttg tattttcaag 3684001 atttaatttt aaagcggtca caaaagactc tagcttttct tcattacaat taatttcgaa 3684061 caagttggag ttcgacttac tttctttata atcatcaaat ataattttaa tcttaattct 3684121 gtaatttccg ttttcttgat caatactaag aaataagaat ggttcaatag tctctaaact 3684181 gatactgtct tgatttcctt ttatcatagt ttcgatccca gatatcaaca ccttatattc 3684241 actttctaat aaaacagcag aaaaatcgcg aacgacggct ttcttatttt ccaacaattc 3684301 aaatacagat aaaataaatg gatcatcgtc caactcttga taccttctcg gtgttaattc 3684361 aagttctata caatcatctt ttattttggc catatttcct cctcatttaa agtttaagtg 3684421 agggtagttg tcatcccccc ctcgcttaac cttattaacg ccttctctta gatttatttc 3684481 cttttccgtg tgtatggaat acgtgtttag aacccttagc tcttgaactt ccataagctg 3684541 tgattacttt acccctttta tttaaaacaa ctgtagcttt ttttccaaca tatttcgttg 3684601 ccccattagg ttgttttatt acttttttag ggcttcgcac agcattcagt ttggccctta 3684661 aattgactcc acggcctcca tttcttccta tagattgatt aagtccatgt cttgtatgac 3684721 ctgtgatttt aactgccttc ttcgtaaact tataggcgcg actagcaccc ttaaatatct 3684781 tcccaggacc aaaattagaa gcagctgccc aagcagcacc tttccatcct ttacctgatt 3684841 tatatgcctt atatccatca taggctgcaa atccggcatt taccacaagc catacccaat 3684901 gcccgtccgg atcaacattc atcactgggt tattatttcc ataagcatac ccattctgat 3684961 ccaatgaatc tccgtcgctg cccgggtctg ggtcgagcga taggaacacg ccgtttcttg 3685021 gctcgtagta gcgggccatg agatagtaca ggccggtttc ttcgtcgtat tggtagcctg 3685081 cgtagcggta gcgattgtct tttacttcgt cgcttgcttc ggtttttgtt ggatttcccc 3685141 atgcgtcgta ttgatacttg gcaacggttt ttccagtgct gtctgagatc gcgatgatgt 3685201 cgccgtgagc gttgtagtga tagaaatatt tcttaccatt ttctgtgtag gataacagct 3685261 ggccgctgtc tccgtacgtg tatgattttg tgacgttgtt gtccgcgtct gtttcataca 3685321 agacgttcaa gctgtctccg tcgtagaagt agttcgtgac ttttccgttg acggtttttt 3685381 ggattctgtt tcctttttcg tcatacttat atgttgcgaa tggcttgtct tcgccttttt 3685441 tggtaacggc ggtcaggtta tcttctgcat cccacgtata tgtgaatttg ccgtcggatg 3685501 tgcggttgcc gtttttatcg taagagatgc tttcatcatt gacttttgtc agctggttca 3685561 tgatgttgaa ggaagcgttc accgttttgc ttgagccgtc ttttatagtt gtaacggttt 3685621 tccggtttcc gaatccatca tatgtgtatt caataacagt accgtcttca tgggtttctt 3685681 tgacaagctg attcagcttc ccatactcat attgcacctt gccgcttgct gagctgttta 3685741 tcgttgtgcg gttgccgttg gcatcatatt catagctttc cgtcagaatg tctccgccgt 3685801 ttttgtcacc gatatgcagc gagcttacaa ggtttctttc gtcatatgaa aaacttgttc 3685861 cgccgccgtt gcccgtaata aaggtttgga cgtttccatt ttcatcataa tcaaatgaat 3685921 atgaggatgt actgtctttc atctcaatca tttgatccag cttgttatac gtaaattgat 3685981 tcgttccttt ttggtcccca tgaatccacg agaaggtttt cagcttatcg gagtcactag 3686041 gatatgtcca agtttggctg ccgccgcggt ctgtcagttc ggttaaacgg tttttgttgt 3686101 caaatgtccg tttctttgtg gtgttctgct ctttattgac gaccgacgtt tcatttccat 3686161 ttttgtcata cgtgaaaatg tacttttctg taccgttata cgactttgat ttcacccggt 3686221 ctgttccatc ataagaaaga gacacttcgt tgccatttgg tgaaatggtt ttggtcaggt 3686281 tgctgttggc atcatattcg cttgctaaca cattgccgag agggtcagtt gttttgacaa 3686341 gcttgcccat gacatcatat tcgaatttat aggtttgatc tgctcctgcc cggatggttt 3686401 tgcttacctc attgccttcc ttatcatagc tgtgaaggat agacgtgccg ttagagagcg 3686461 tcatgtttgt caattggtct gcctgatcat acgtataggt tgttttttca ccttttgcat 3686521 ctgtttcaga cgttttctta ccagtttcat cgtaatcagt tgaagtggcg taacctagtt 3686581 cgtcctcttc cttggtcaca tagttgccat tactgtcata cgtgctttta gtcagaaggc 3686641 ttccttcaat caaacggata tcatcaaacc agactgtgcc tgtcgcactc ttttggaaca 3686701 gaatactgat atcgacttta ttgatcggct ttgttttagg gatgacgaca gctgctcggt 3686761 tccattcctg tgttccagaa gggaatttcg cattgtagat gcctgtgctg ccgtcagcgt 3686821 aagtgacatt cgcctgcaga gaatagtctt tttcatctgt aaatttgacg ctgcttgctt 3686881 tcgacattcc tgtcagtgtg agataaaccg gtttgtcatt tgcgctttgc cctaagacaa 3686941 cggtttgttt tgttactgat ccggcttggg acgcactggt ccgggcagct tttaatgata 3687001 catcatcatt aaagccttct tcagaatcaa cggatgctcc gcttacattc cagttttccg 3687061 ttgctgatgt gaagctgctg ttttgaactg ggttatagct tgatgatact tcgccttttt 3687121 ccagctggac ttcatcaaac catgcttttc ctttgccatc tttatcttta tgatcgactt 3687181 ccatatacac aacagctttg cctgcattcg ctggagtcgt aaaagtgatt tgccgttttg 3687241 tccagtcatt ttttccggct aatgcactgt attcattgtg aatccattga attcgttttt 3687301 gatctttgtc tcgcaaatca atgttaaaat aggctcttga tttcgcaaga tctgttttga 3687361 ttttcccgct taatgtatag gttgtattcg gctccagctc aactgtttgt gttgctgacg 3687421 aatacccatg atctgttccg gcagacgttg attggctcaa gacctccaat gcctttgatc 3687481 cggaaagaac tccgctttta tcggcgatga ctgaaatttt gccgctgtct ttagaggcag 3687541 tcagattcca gccggatttt tgagcttcaa agcttccatc tttcaaaata ttagttgaag 3687601 ctgataaatc tttgctcgat tgaatctggt ttccatattt atcataaaca gctgctgacg 3687661 atgattttcc gctctgatcg gtttcggata cagcatccag tccgtcataa gcaatatccg 3687721 tgacattgcc ctcggtatcc ttcatctttg tgacatcgtt gtttttgttg tattcgtatg 3687781 tctcagttcc atatgcatct ttaaccgacg taacgttgcc atctttgtca tattgatagc 3687841 tttccgttgc ttttccggtg ccgacgtcat ttggatctac atcttctaca acattgttgc 3687901 cttcatactt tgtattcgtt gtaattttta acccttccgc atcatcaatg acctgaatcg 3687961 gatttcccgc ttcattatag ccatactgta ctttccggcc atttggctgt gtcatgagaa 3688021 gcgtcttttt atcagcatca tagctgtaga catatgtttc ttttttagcg ttgatcgctt 3688081 tttcgagacg gtgaccgcta tactgatatt cggtaaagac aggctttgct tcggtactgt 3688141 tagctgaata ttgtttgaca aggcgccctt cactatcgta gtcatagctt gtgacagtcc 3688201 cgtctgtatc tgtaaccttc ttcagcaaat cattctcata tgagtaggtg actttcttat 3688261 tcttaggtcc tgtgatggac gtcacatggc cgttttcatc ataggtaaat gtaagcttgc 3688321 ggcctgatgc atctgtaatg gcggtcagtt gatttttgtc attgtaagta tagacagttg 3688381 cattgttatg gccatccact accttttgga gtttgccgcc ttttttattg aaataagcgt 3688441 tggtttgatc ctttgttttt aatatgaact gatcagctgt ttctgttaat tcaagatata 3688501 caccggtcgg cggctgatac gtgccatcgg cttttttcgt gaatcgatgt gtcgtagcgt 3688561 cttcatcgat atacattgcc ccgccatccg ttgagatgac agatgtttct gcatcagcat 3688621 accagccttg tccaaataag tgatcagagc tgtcaagact gttgtaggtt ctcgataagc 3688681 caagtcccgg accgcgtcca tcaattgaca aatcttcttc attcacaatg acattgcctg 3688741 tcgcaccatt taactggccg cttgggatat caatgataga ccagtactct tctgtaccta 3688801 ggaattctgc gccttcatgg aacgttgggt taaagggcgc cgttggaatc gtttcaccat 3688861 tcgcatcata ggcgacaagc gtgaaagaat aattcttctt ccctttgtaa ttcccatttg 3688921 cattgttata gacaggtgat ggatcgaggg ctaattcccc gccttttcca tctgtatgaa 3688981 gcttatagct tccggctttg atttcctcag aagtcggcca gatgttttta ttttgggttg 3689041 tccaatgatc agcatcacca acatcaaagg actgatattc tttaccgttg taaatgttaa 3689101 ctttatagcc cttcgcattt tgaacctttt cccatatcaa attcacataa cccgtttgac 3689161 tcgattttgt atttgtatac aaatagccag ttacattctt tggcctagcg atatcaggaa 3689221 gtgccggggt agcagccggg gatgcaatgg cttcgccgtc tttgttgtat gcgataattt 3689281 taaacgagta atttcttttg gctccatctc ccccggcgtt tttataggtt ggtccgggat 3689341 tgatcggcag ctctgctccg cttccgtcct ttaggtgaag agcatatttt cccgccttga 3689401 tttctgcact tgtcggccag atctttttcc cttttgtggt ccaagacgtc tgatttccga 3689461 gatcaagtgt ctcaaagcct ttcccattga acacctgaac cttatagccg gttgcaccgg 3689521 atacagcttt ccaagaaagg tcgaagtatc ctgtggcatt cccattattg tagccctttg 3689581 ctgacggtgc ttgtgctttt cctacattag ggataacggg ctttgccggt gcggacatcg 3689641 ctccttcacc ttggtcaaat atcgcactga cgccaatcca atagtttttg cttgtagcat 3689701 agcttccgcc ggaattctta tagaccgggg atggatctaa tgccaattca gctccatcct 3689761 tgccgtccag atgcagttta tatctcttgg aggcaatttc tgcgctcgta ggccagattt 3689821 ttttaccttt tgtgctccac gacgtgacgt tgcctgcaga aatcgcttga tattccttac 3689881 cattgtaaat ccatacctta tatccttttg cgccttcaac ctttttccag ctgatatcga 3689941 aataaccagt ggaatcgccg ttgtgatagg ctttgattgt aggtgtgttt ccctttggaa 3690001 tggtatacgt cacttcaata tatggtttat tggcggagtt cgctgaagaa attagttttt 3690061 tccaatattc cttgccgttt ccgtttgtat gaagcttaaa tccatagttg gccccgccgg 3690121 agttccatga ctttacagca gcggtcacat cataactcgc ccactgtcct ttatggacgt 3690181 cggcttttcc gatattttta gatgccggtt tggtgttcca tgtcactttt gcattatcat 3690241 aattgctgtt gaccgtatcc agccaaaggc cggttgcctt tgttccataa taggaatggg 3690301 ctacgtatgt ttttaatgta gctttagtga cagtcatatt ttgaattggc tttaggttgt 3690361 taaatttcat gaacgcatag tttgtgcctg ttgttttgtc ataatagccc gttttcagta 3690421 cataggcctt taaattagca tcccattttt gtgaggaggc cgaatagttc gtcgtcgggt 3690481 aggcactcat gacaaacgta tccgatgaaa cagataaaga agttgacggg tcgatagata 3690541 ctggatatac gcgttctggg tctttcagcc agttctcgtc tgccgtaaga tgaagcaaat 3690601 acccttcttc attcttttcc agcttatagc tgactttgtc tgaccgttca acctcgccgg 3690661 aaagctcatc tagttttgaa tccgtcataa aaggcttagg cacagaaaaa acaacttttc 3690721 ctttttcatc agaaaaatca atggatccat cctcttgttc tttagcctgc aaatcggttt 3690781 ttaactgaaa tgtaaatgtg ttgtatccat tatactgatg aaggactaaa tcttctttta 3690841 tgttttcatt gaatgtgaaa gtctgaagat caatattcgg aaacacatcc ggatacacaa 3690901 tctcattact gtcagtctta taatctgctg aggtatcttt cggagtaagt gaagttttat 3690961 tcgggccttt cgcttctgct agtgaatatg taaccttatg gtcattatgc tcaaaagtcg 3691021 cataaagccc gttcttcatt tgcttttgaa aatctgaatt caaaatagcg ttctctgtct 3691081 cgacttgttt gcttgtcgac tcttttaact caggagaaat gtcttcccag tcggcatccg 3691141 gtgtttcctt tgtatgaata ggatcaaggt atacttcctg tttatagaca ccgtcacctt 3691201 cataatagag ttttgtattt tctgttcttt cagaggtgat ctcaccctct ttgtttatat 3691261 cttttggatc aaaaggtaca gcttcctcag tttgttcttt ctgaagagtt tcttctggat 3691321 catcggcagc aatacggttt ccattctctt cttctgtaga ttttgctagt acatcggctg 3691381 gcactaatga aatcattaaa gccaacacta aaaatgctgc aatgaacctt ttaaagtttc 3691441 gcctctttct ttttttcatt tcctctctcc ttttgtaata aaagtaatat ttactcaata 3691501 atcttaacta gactgaaata tcattacaat atttttctag aaaatttatc ttattttaag 3691561 gattagcgag agtcaattga cctaaaacaa aaaaaggccg cataggcctt tttacatttt 3691621 ttattgtatt tgttcaatat ccgtaccctc agctgtcaca ttcgccttcc cctgcctcct 3691681 gacaagcgtc aaggccatgc ccgcaaagat cattacgatg ccaagcgttt gatagaggtc 3691741 agggcggaag cctgtgaaga cggtatcgag cacgatcgcg acagcggggt cgagaaatac 3691801 aatgattgaa ataaatttcg ttgataaaaa tcgtaaactg tcaaaaaaca gcaaatatac 3691861 aatacccgta tggatgatgc cggtagatac caccataatc cagtttccct gagataggtc 3691921 cgcaaaagcg ccaaagtgaa taaacggaat caggatgata acccctaaac ctgtctgcaa 3691981 gaaggtggtc gtgtaaggac tgagattgtg aatgcctttt cccaataaag tggtgaacgc 3692041 ataaaacagt gcggcgagaa ctgcccatat gatccctgat cccatcagct gtgtcaatga 3692101 tgtgctgccg ttaatcccgg aaatcagcgc agtcccaaga aagcagatga taatggagct 3692161 gacggagatc acatttaatt tctctctgta gaagaagctc cccagaagaa gaacaagcac 3692221 cggcgctaga tgataaacag agatggcaat tgtaacggac gtttcttcaa aagacttaaa 3692281 taagaacacc cagttgaata caagaaagaa accgcacgcc aatgtttgca gcacgtctct 3692341 cttgctccat ttttcagttt tatactggcc ggacgccagc cagcaaaagc ctaaaaacag 3692401 cgtcgcgcaa aggcagcgga caaagaccaa ttcaaatgac ggcagattgg tatgctctga 3692461 gaaaaagccg atggagccga aaatcaccat agagatgacc attttgatta cggctgttga 3692521 tttttgtttt gacgatatgg aaggatcctg ttgcatcaaa cgtattctac ctccaatact 3692581 gcatagcata aactgttttt tgtgaattca gaaatctaca catagaattc ctctttttta 3692641 catgtagata ttataacact tctattctaa ataaaaaaaa gcgcccaagg gcgctttttt 3692701 tacaaatcta tcgaacaatc aaaaccgggc atgttgataa ttgagacact ttatggctga 3692761 cgcttccaag catcatttct ttcaggccgc tgatcccccg gctgccaact acaatcaggc 3692821 tgacgccttt ctcttttgcg tgatttagta tctcatgcgc cggctcgcca ttcgcgtaaa 3692881 tggtttcagc ttgaacgcct ttttcggctg ctttttcttt tgcattctca aggattttca 3692941 ggccctcttt tttaacctcg ttcctgattt catcaataaa gtgttcaggc acatagacaa 3693001 ttcccgtcag agaagaagtc gtgacgacgg cttctctccc cacatgaaga atgcttagtt 3693061 ccgcttgttg ctcttttgcc aaatgcactg cggcatcaag cgcttttgca ctcatgtctg 3693121 atccgtcaat cgctactaac attttgttaa acatgctctt cccgcctttc ggactgtggg 3693181 tggttcatct ttctctttta ttgtccgcct gcatttcgtt attgtcaatt gaagcgcatg 3693241 agttttcaaa aaattgtcag agactctctc cgtttgtggc gataacctgc tgataccagt 3693301 tgaagctttt tttcttgatg cggttaaatg ttccatttcc ttcattgtcc cggtctacat 3693361 aaatgaagcc gtagcgcttt ttcatttccg cagtagatgc gctgacaagg tcaattggcc 3693421 cccatgatgt gtatccgatt aattcaacgc cgtccgcaat ggcttcgcgc gcttcaatta 3693481 aatgatcacg cagatagttg attctgtaat cgtcctgaat cgtgccgtcc tcttcaacct 3693541 tgtctacagc gccaaggccg ttttcaacga tgaacagcgg cttctggtaa cggtcgtata 3693601 aggtgttgag cgtgatgcgc aagcctttcg gatcaatctg ccagccccat tctgatgatt 3693661 tgaggtaagg gtttttgact ccgcccagca ggttgccccc tgattttgca agctcttccg 3693721 gatctgtgct cgccgccatc gacatgtagt agctaaatcc aatataatcc accgtatgtt 3693781 ctttcaagag ctcttcatcg ccttcagcca tttcaatttc aatattgttt tctgccagat 3693841 agcgtttcat atatcccggg tatgcgcctc ttgcctgaac atctgagaag aaaagtgttt 3693901 tgcgctcatt ctccattgcc gcgaagacat cctccggctt agaagtcatc ggataggttg 3693961 tcgttgccgc tatcatacag ccgattttcg aatcaggaat gatgtcgtga cccgctttga 3694021 cagcaagagc actggccaca aattggtggt gtgccgcctg gtacatcgcg tttaatttgt 3694081 tttctccttc ttcaaaaaca agaccgcctc cggtaaatgg cgcatggagc actacgttaa 3694141 tttcattaaa cgtcatccaa tacttcactt tgtgttgata gcgtttgaaa accgttttgg 3694201 catagcgttc ataaaactct atgactttgc gattcttcca gccgccataa tttttcacta 3694261 aaccgagcgg catctcataa tgagagatgg ttacgacagg ctcaatatga tgctttaaca 3694321 gctcatcaaa cagatcatca taaaatctga ggccttcttc attgggctcc tcttcatcgc 3694381 cattcggaaa aattctcgtc cacgcaatcg atgtgcggaa cgccttaaat cccatttctg 3694441 caaataaggc gatatcctct ttataacgat gataaaagtc aatcccgttg tgatacagat 3694501 tcaaggaagt cattgattca tcaaatggag acatgatccc gttcggcgat acgtcagctg 3694561 tcgaaagccc cttaccaccc tcgttataag caccctccac ttggttggca gcaactgcgc 3694621 cgccccataa aaatccttct ggaaatcgtt tttcatttga actcatattg atcaccccat 3694681 tagttttttc aagataaagc aagcagcgct tcttttggct gcactttacc gatctctttc 3694741 accggcgaaa acgaatattg gtctgtgttg gtcacaatca ccggggtaat gacgtcatat 3694801 cccgcggctt tgatttgctc cagatcaaag gacacgagcg gatctcccgg tgcgaccttg 3694861 tcgccttctt tgatgtgagc cgtgaaccat tgtccctcca gctttaccgt gtccaatcca 3694921 atgtgtatga gtatttcagc tccctgatca ctcgtaatgc caattgcgtg ttttgtttta 3694981 aaaatggtgg taacgcttcc acgaacaggc gaaacaactt ctccttcttc aggctcaatg 3695041 gcaaatcctt ttcccatgac cccagcagaa aacactccgt ctttgacttc acttaaggct 3695101 ttcacttctc ccttaatcgg gctgtgaatg atctctctgc tgccttcatg cactgccggc 3695161 tgctggctgc cgtcagaagg cacatcctcg aatccaagca aatacgcagc tgctgttccc 3695221 gccgcaaacg caatcacaag gccgatcatc gcgtaaataa acgttgggcc gataaagaca 3695281 gggatgctcg gcagacctgc attccccccg acgatatagg aagcaacacc cgtcatgccg 3695341 taaaacgcgc caccggctgc accgccaatc aaagcggccg caaacggctt tttcaatcgc 3695401 atattcacgc cgtacatcgc aggttctgtg atccccatca gcgccgtgat gcttgtggta 3695461 agcgcgagtg atttaaattt tttgtttcta gagcgaagga agacggcaaa tgatgctccc 3695521 gcctgcccca tattcgccaa aaacatagcc ggcagtaaat aatcgtggcc gttttgagcg 3695581 atgttgttga tcatgatcgg cacaaaggca tagtgcatgc ccgtcataat gattaaagag 3695641 aatgtacccg ccagcaaaat cattgccaca agccctgcat gatcaaacaa ataattgacc 3695701 ccagaagaca agtattctcc taaaatagcg ccaagcggac cgactgtaat caatgtcagc 3695761 ggcacgacaa tcaatagcgt gaatgtcgga accacaatca atttgagaga tgcgtgtgta 3695821 aaacggtcaa tccatttttc cacgtatgaa gcaatccaaa tcgacagcaa aatcgggatg 3695881 accgttgacg aataagtggc agcggttaca ggaagcccga taaaggaaat cggtttcccc 3695941 gcaccgagca gggctgtcaa atccggatgc aggatcgccg ccgcaatggc agccgctacg 3696001 tacggattgc ttccgaattt tctcgccgca ctcatcgcta gcaggagcgg caggaagtag 3696061 aacgcaccgt caccgacagc cgtcaaaatg acatgaacct ggctcttctc cgccatccag 3696121 ccaaacgtga ctgccagcgc cacaagtcct ttgatcatcc ccgctcccgc aatcgcaggc 3696181 agaatagggg taaacacccc agaaatcaca tcaaagaccg cactcagcac attctttttc 3696241 tgagaggatg aaccagcgct cttttcatca ctgagattgc tgtgccgcac aatcgcctga 3696301 tacaccttcg gcacatcgtt tccgataatg atttgaaact gctcgccgct gatattggtg 3696361 cccatcactc caggcagctg ctccagctga ctgcgatccg ccttcgcgtt gtcatgaaga 3696421 ttaaaacgca gcctcgtcat gcagtggatc acgcgctgaa cgttttcttc accgcctacg 3696481 agttgtaata tgtccttcga taatttatca taatccatgt gtatacctcc tttttatggg 3696541 gggactgctg gatgaaaggt ggccgccttt caccagcttt ttttgtatca aatgctgcat 3696601 cacctcctaa aagagaataa aaaaacctaa atgacacaga ttgcgagagt ctcctcctgc 3696661 acctgcacca tttaggtttt gcctgctttc gcagtaacaa tcctgacggg tcgttttatt 3696721 tgtttgtagg tatactttag cactagattc gtgagatgtc aacgctttca tttttggtgt 3696781 tgactatcgt ttctagaaca aaagtaatca taaagatttg aacttagtat taacttcaat 3696841 aaaaaattat tgtaattaaa aaccttgaaa ggcatttttt ccaatcaagg ttatgaatcg 3696901 ttaccgttta aattttttta aagacttctt tatctgtact attacattct ttagccaatc 3696961 tattggttct aaattaaacg caggaagata cacgccatct gcgcaagatt gaatgtaatc 3697021 gtttttctta ttgtctgaat gctcactttc aataaaatcc gttaaaaaga caatagcatc 3697081 ctccaaatat tccttacttt cctctattaa taactcttgt atagcgtcat caggagtttc 3697141 aatatcttga tggaatgttc cagctaaaaa ctgaaaaaca gggtccttct gtttattgat 3697201 caataacatg tcatcttgct cctttaaggg agaggtaacg ggataatgtt aaaatcattc 3697261 atcatctaat aaatcaagat aatactgatc attctcttct atttttctta agaactcggt 3697321 aagagaagtt gcaatttgaa tatcataata gtaaatcgga tttttattat tatcatttaa 3697381 ttcaattgac attaatgccg attcactacc ttcaaaaaat attaatttat cattctcaaa 3697441 ctcatcatat atttctatgt caggataaaa ttcaaagtca tttatcctca atcgaaagtc 3697501 tcttacagaa tatggatcca aaatgcgatt agtattaaac tctgatcctt taataaaccc 3697561 atagccaact tctaaataaa aattcactaa ttcactaggt aattttaagt ttaaattttt 3697621 ttcaacctct tcaatctcac tttgattcac tggataaaaa tcattttctt tgtttgattt 3697681 tataaaatta taactcattt ttttttgcct cctttaaata attcatttgc tggtgagcct 3697741 gtaccatgaa tcccagcttg atgctcgtta ggaaattttg ctggatgcat attccaccat 3697801 tcatgttctc cgccaaaagt attttcaatt atatggtgag catcatactt atcccctttt 3697861 tttctaataa ttttacctgt tttttcagat acaacatttt ccttataaac aggccatttt 3697921 tgtccagtgt tttcttccca ttcttttata actttatttt ttactttatc aaatttagtc 3697981 ctgtgttttg cagtctctat tggtgacatt tttttatatt ctttatttct taatgcttcc 3698041 tttaatttat ctatttgatt tttaggtaat tctctacctg tgcgttgttc tatatctcta 3698101 gcatactttt ttattaaatc agaattaatt ttattagcag atccacttac atcattcgca 3698161 attttccctt tatccttagc aacgttttta acttccgaag ccttcttagc ctttttccca 3698221 ttattaataa gtttattaat atctattaac ttttctaact tagctatttt ggcaaatggt 3698281 actgagttta tggaggcaac aacacggtct ttccctgtga ctttttcgcc tgataccgga 3698341 tctctgcccg tggctgcttt aaatagatca tacacgccgg taagttctac agccgtctct 3698401 aaaattttca catatccatt ctcatccact ttaatgtccg aaagcgagac gacaggttca 3698461 agcttcatgt cattaccaga tatgtataca ttgtaaagtg tatcattata aacgacttgc 3698521 ttaacctctg catttgagaa atcagttttt atatgttctc tatgttcact cgtattatac 3698581 actttaccat tgataacgat gatattttta cttacctttt tagaatcacc cgttttgaca 3698641 actgaatcca ctttagactt ttcattctcg gctaatttct tcagcatcat ctccatcggt 3698701 gaatcatccg cctgcttcat ttgcgggtta atcgcgccga agatttggtt gatgttttct 3698761 tcttcctgtg atttcaggat ggagccgctt ttgtagcctg tgatttcaat tttcgggccg 3698821 gtgtacatgg tttcgagctg atcaatgtat tttttcatcg tttgaaaatc tgattttgcg 3698881 gcttctagtg cttgggtttg ctggccgtca aattgaaaga gcttattcag ggtgtctgaa 3698941 atcagccgct cagcctgttc tgtttccatc cgaaaaaagg aatcattgac tgtcggcagg 3699001 ctgacgatgt gatctatggc tgatgtctgg cgattgactg cgtcagtgag ctgctctgtc 3699061 acttctcgtg catgcttgac cccatgtctc gcatcgtgtg agagaaaagc ctctgcgatc 3699121 atgccgtggg agttagattc tacagaggaa atcgcatgct gtgtttgttt cagcactttt 3699181 ttgtattcgt cgataaatat gccaaagaaa aggagaaaag gcttgtggca ctcctcgtaa 3699241 aaggtccgga tggcatctcc gccttttcct ttcagcgcat ccttcatgcc tgccagatgc 3699301 tcaacgcttt tttccagctt ctccagctgt tgtttttgct tgtccagttt ctcaatcgta 3699361 tgctgaatgc cctcgtgaag agcgtggaca tctaatgttt tcaatccctt gtcctcccgc 3699421 gctttatttc atggaagatg atatgttttc gtccgtttcc ttcatggcgt ttaccgcgct 3699481 ttccgtttgt gcgatatgct tggccagaac agacgcatat gcttcagtga gctctttgat 3699541 gtccttattt aattgctcga tggacttcac aacattcaaa tggtttctgc ctgagagatg 3699601 accgggcaat gaggacttga gttcagctga attcttgagc tgagaaagcc cttgcttcac 3699661 tgtgtcatac accattttaa tttcctgtgc catttgtgct cacctcactt tttatgtttt 3699721 tccttctcta tttcatgctc tatcctcgtg atttggcgtc ttatagaata cacatcgccc 3699781 tctaatgagt ggatttttcc ttctatgctt tcgatgattc cgctgacttg atcgcttttg 3699841 atttgctgat atgctttgtt cattccttca cgaatatctt caaaccgctc agcatgtgtt 3699901 cctctccatg cctcccggtt aagatgaggc cggtgaatga gatgctgggc ctcagagaaa 3699961 tcgtgtttga tttgcctaat ttcgtgcagc actcgtttta attgatggat ctgttcctgc 3700021 ttttcatgta agtcggcttt taccgaatgt aacaacattt cactatgcat gccgcaacac 3700081 ctcgtgtttc tatcaaactg tgtaaattct ttacaataca gactattttc atattacatg 3700141 atgggtcata ttggataaat aggtaaaaag gattgtcttg agaggtatag aactggttct 3700201 aaattgctaa aaatacgatc tcatcaccct atgaaaggag aaaacaatca tagtagggac 3700261 tttttattta agcctttaat ctctcctcca gttctaattt ttcctcccac ttaactgttt 3700321 cttatagtca ataaagctca taaaaaaaca ccttccctcg aaggcgcttc tccatcttat 3700381 ttagatcccc atacagcctc accgctggta ttcagcacac taaacgtcat gacgttcttc 3700441 tctctcaccg aatcccactg gcgtaaaaat accccgttat acttcttgcc tgctaacgtg 3700501 atgtcggcgg tgttttttcc ggttttcctc catgttccgg tcatttcccc ggaaatggtg 3700561 tggtttttgt tgagctggat gttgatggtt tgtttgatgt cggctgagat gtcttttccg 3700621 tgctggataa gtttgtatgt tcctgtgatg tctttttgtt ttacttcttt caatgtttcg 3700681 cccgcataac gatatggtgc tgctaccggc cagccgtctt tgttcatgaa caattggtgg 3700741 actctgactt cgtgttcttc acccctgccc gggaagcggg tgtggaagat taaataggaa 3700801 cgcccggttt tttcatcata gtatgcggag ttgtggcctg gtgagacgta cccggtgcct 3700861 ttttcatttt ctgtttcaaa agtgtagctg cccatgagtt tgacgccgta tggttcgatg 3700921 gaacggtcgt cgaagaatgt gcctcccttg ccgcggacgt cgagcattgg attgccttct 3700981 gcatcatagt aagggccgtc cggtttcttg gagcgggcca cacggatgtt gtagccgcct 3701041 gttgcatcga gaccgccata tgataggtat aagtagtagt attgggtgtc tggattgtag 3701101 agaacatacg ggccttcgat tctgctgtgg ttgccgccga gcagtttttt cccatatccc 3701161 tgtccaggaa gcgggaagcc cgttttcgga ttcatttcaa gtatgaaaat gccgcctgag 3701221 tatgatccgt acaccatcca cagcttgccg tctttatcaa agaaggtatg cgggtcgacg 3701281 acattcggat gtttggttgc atcatacggt gttccatcgc tgcttgtgcc ttccattcct 3701341 gatttcaaaa agatgccttt gtttttgtat gggccttcga tgttgtcagc aacggcaaca 3701401 cccatggcgg atcttggcga atcgccgcgg caggcgttgt agtacatgta gtatttgccg 3701461 tccgccagct gcgtgacgtc agccgcccaa agagtatcgg attgcgccca ttcgaaggtt 3701521 tcttttaatt cttcatagac attcgggata agtgggttgt cattgcttac gctggtggtc 3701581 agctgctgcc attgcatgag gtcattcgat ttagctgaag cgagatgaga tccaaaaaca 3701641 taaaaagtgc cgtttgtttc aatgatggaa gggtcatgga cgctgacttc tttaaatata 3701701 ggtttttgtg catagacgga gtttgggagg gtgaaggcca tgataagagc tgcaagaaaa 3701761 catacacgga acaatcggtt gaacatctaa acaattcgcc tctctttttt attaaatttt 3701821 aaacgcttac atttctctat gaagataccc cggcctatta aaacagccga atgttttcat 3701881 attcatccag ataggtgatt tctcacttca cttacatagt cagactgatg tctgtctgtt 3701941 ttgcgcagaa cttgttgctt gcatatcctc tccttcatag ttcaactctt ttgctgtttc 3702001 tccttcttgc atcacgtctg tttttctttc gcgtacatgt aataactgct ttgtcaggtt 3702061 ttgcatcaac tgtgatacag ccatttcgtt gtcggcgttt tttaagatga tgcctgattg 3702121 cccgtcaaca ccagagtcat tcggctggct ctttataaaa cgccttgcga aaaatacgac 3702181 ttagtaaacg catattgaga gttagacagc ggcgcttgcc tccttgtctg gatatcgtgt 3702241 gcaatcgctg aaaaaacctg ttctgctttc tgcgtcacgc tattacaata gcaatctaac 3702301 ttgttaaaga ctataaaaaa accttttgac ttctgctgct gaaccaatta atataatact 3702361 cagttaatag ttatcagaat ttttaggaat tgagtgattc atatgacact gcataaagag 3702421 cgtcggatcg gccggctgtc tgttctcctg ctgctgaatg aggcggaaga aagtacgcag 3702481 gttgaggagc tggagcgaga cggatggaag gtctgtcttg gcaaggtagg atcaatggac 3702541 gcacataaag tagtagccgc aattgaaacc gcttccaaaa agagcggtgt cattcaatct 3702601 gagggttatc gggagtcaca tgcgctttat catgcgacga tggaggcttt gcatggcgtg 3702661 accagaggtg aaatgctgct gggatcgctg cttcggacgg tgggattgag gtttgccgtt 3702721 ttgaggggaa atccttatga aagtgaagcg gaaggcgatt ggatcgctgt ctcgctttac 3702781 ggaacaatcg gggcgccgat taaaggtctt gagcatgaaa cattcggcgt tggaattaat 3702841 cacatatgaa acagcccata gatcttagac gatagggggc tatgcgtgaa aacagaagtt 3702901 cacagcatag ctcctttttg tatgggcgct ttaccaaagt aaagaaaaag gagttgggct 3702961 tatggtgact ttagacggtt cttcattgac aacagccgac gtcgctcgtg tgctgtttga 3703021 ttttgaggag gcagcggctt ctgaggaaag tatggagcgc gtgaaaaaaa gcagagcagc 3703081 agtggaacgg attgtacgcg acgaaaagac aatctacggc atcaacaccg gatttggcaa 3703141 attcagcgat gtcctgattc agaaagaaga ctcggcggcg ctgcagctga atttaatcct 3703201 ttctcatgcc tgcggagtcg gcgacccttt tcctgagtgt gtttccaggg caatgctgct 3703261 tttgcgcgcc aatgcgctgt taaaaggctt ttccggtgta cgcgctgagc tgatcgagca 3703321 gttgcttgct tttttaaata aacgcgtcca tcctgtcatc cctcagcaag gatcacttgg 3703381 cgcaagcgga gatctggcgc cgctttccca cttggcgctt gcgctgatcg gacaaggaga 3703441 agtctttttt gagggggaaa gaatgccggc aatgacaggc ttgaaaaaag caggtattca 3703501 accggtaacg ctgacatcca aggaagggct tgccttgatt aacgggactc aggccatgac 3703561 tgcaatgggg gtggtcgcct acatcgaagc tgagaaacta gcctatcaaa cagaacgaat 3703621 tgccagctta acgattgagg ggttgcaggg aattatcgat gcatttgacg aggatattca 3703681 cttagcccgc ggctatcagg agcagatcga tgtcgcagaa cgaattcgct tttatctatc 3703741 tgacagcggc ctgacaacct cccagggaga actgcgggta caggatgcct attcattgcg 3703801 ctgtattccg caagtacacg gtgcgacttg gcagacacta ggatatgtca aagaaaaatt 3703861 agagattgaa atgaacgcag ctacagacaa tccactcatt ttcaatgacg gtgacaaagt 3703921 gatttccggc ggaaactttc acggacagcc aatcgccttt gccatggatt ttctgaaaat 3703981 cgcaatatca gagcttgcga atatcgcaga gcgtaggatc gaacgacttg tgaatccgca 3704041 gctgaatgac ctgccgccgt tcctgagccc tcatcccggt ctgcaatccg gtgcaatgat 3704101 catgcagtac gccgcggcct cactcgtttc tgaaaataaa acactggccc atcctgcaag 3704161 tgtggattcc attccgtcat ccgccaacca agaggaccat gtcagcatgg gaaccatcgc 3704221 cgctcggcat gcttatcagg tgatcgcaaa tacaaggaga gtcattgcga tcgaagccat 3704281 ttgcgcattg caggctgttg aatacagagg catagaacat gcagcgtcct atacgaaaca 3704341 gctttttcaa gaaatgagaa aagtcgtgcc gtccattcag caggaccgtg ttttttccta 3704401 tgacattgaa cgcttgactg actggctgaa gaaagaatct ttaatacctg atcatcagaa 3704461 taaagaacta agggggatga acatatgact gatgtaaaaa aatcaatccg tgccaacaga 3704521 ggaacagagc ttgaatgctt aggatgggag caagaggcag tgcttcggat gcttcgaaac 3704581 aaccttgatc cagaagtcgc cgagaagccg gaggacctca tcgtatatgg cgggattggc 3704641 aaagccgcac gggattggga cgcttttcac gccattgagc attccttgaa aacattaaaa 3704701 aatgatgaaa cattgctcgt gcaatccgga aagcccgttg gcatgttccg tacacacccg 3704761 caggcccctc gcgtgctcct agcaaattct gttcttgttc cgaagtgggc agactgggag 3704821 catttccacg aacttgagaa aaaagggtta atgatgtacg gacagatgac ggctggcagc 3704881 tggatttaca ttggctcaca aggcatattg caaggaacct atgaaacctt cgctgagctg 3704941 gcgcgacagc acttcggggg cagcttaaaa ggaacgttga cgctgacagc gggtctcggc 3705001 ggaatgggag gcgcccagcc gctgtcagtc acgatgaatg aaggcgtcgt gattgccgtc 3705061 gaggttgacg agaaacgcat cgacaagcgg atcgaaacaa aatactgcga tcgaaaaaca 3705121 gcatcgattg aggaagcctt agcttgggct gaagaggcaa agctggcagg aaaacctttg 3705181 tccattgcac ttctcggaaa cgcagctgag gtgcatcaca cacttttgaa ccgaggcgtc 3705241 aaaattgata ttgtgacaga tcagacatct gcccatgacc ctttaatcgg ttatgttccc 3705301 gagggctatt cccttgatga agctgaccgt ttgcgtcaag acactccaga gctttacgtg 3705361 cgccttgcga agcaaagcat gaaaaaacat gtcgaagcca tgctggcctt tcagcaaaag 3705421 ggctctattg tatttgacta cggcaacaat atccggcaag tcgcaaagga tgaagggctg 3705481 gagaatgcct tcgattttcc ggggtttgtc cctgcctaca tccgcccctt attctgtgaa 3705541 ggaaaagggc cgttccgctg ggcggcgctt tccggagatc cggcagatat ttaccgtacg 3705601 gatgcgttat taaaagagct gttcccgaca aataaagccc ttcaccgctg gattgatatg 3705661 gcacaggaaa aagtcacctt ccaaggcttg ccgtcccgta tctgctggct tggatatgga 3705721 gaacgaaaaa agatgggcct cgccattaac gagctggtta gaaccgggga gctaaaagcg 3705781 cctgtcgtta ttgggagaga tcatttggac tgcgggtctg tcgcctctcc aaaccgggaa 3705841 acagaagcga tgaaggatgg aagtgacgct gtcggtgatt gggctgtgct aaatgcgctt 3705901 gtcaacacgg cggcgggtgc aagctgggtt tccttccacc atggcggcgg cgtcggaatg 3705961 ggctattccc ttcatgccgg catggttgca gtggccgatg gaagtgagct ggctgacgag 3706021 cggctcgcgc gggtcttaac gagcgaccca ggaatgggca ttatccgtca tgcggatgcg 3706081 ggttatgaac gtgccgttga agtagcgaag gaacaggaca ttatcgtgcc gatgcaaaaa 3706141 taaaggagtg atgacatgcc aaagcaaatt gatacgattc tcatcaacat cggtcagctt 3706201 ttgacgatgg aaagcagcgg tccgcgggca ggcaaaagca tgcaggatct tcatgtgatc 3706261 gaagacgctg ttgtcggcat ccatgaacag aaaattgtgt tcgccggaca aaaaggggct 3706321 gaagccggtt acgaggcaga cgaaatcatt gactgttcgg gacgccttgt aacgcctggc 3706381 ctcgttgatc cgcacaccca tcttgtattt ggcggatctc gtgaaaagga gatgaacctt 3706441 aagcttcagg gcatttcata tttggatatt ctggcgcagg gcggcgggat tctgtctaca 3706501 gtcaaggata ccagggcggc ttcagaagaa gagctgctgc aaaaagccca ttttcatctg 3706561 caaagaatgc tgtcctacgg cacaaccaca gcagaagtga aaagcggcta cggcttggaa 3706621 aaagagacag agctcaaaca gttgcgtgtc gcaaagaaac tgcatgaaag ccagcctgtt 3706681 gaccttgttt ccacatttat gggagcccat gcgattcctc ccgaatatca aaacgatcca 3706741 gatgattttc tggatcaaat gctttccctt ttgccggaaa tcaaagagca ggagctcgcc 3706801 agctttgctg atatttttac agaaacaggc gtttttacag tcagccaatc ccgccgttat 3706861 ttacaaaaag cagctgaggc aggcttcgga ttaaaaatac acgcagatga aatcgatccg 3706921 cttggaggtg ctgaattagc aggtaagcta aaggccgtct cagccgacca tttggtaggt 3706981 acatcggacg aaggcataaa gaaattggct gaggcaggaa cgatcgccgt cctcttgccg 3707041 ggcacgacat tttatcttgg caaaagcaca tacgccaggg caagagctat gattgatgaa 3707101 ggtgtatgtg tcagcttggc aacggatttt aatcctggca gctcgccgac tgaaaatatc 3707161 cagctgatta tgtccattgc cgcgcttcat ctgaaaatga ctgcagaaga aatatggcac 3707221 gcggtcacag tcaatgccgc atatgccata ggaaaaggag aagaagccgg tcagctcaaa 3707281 gctggccgct cagctgatct tgtcatttgg caagccccga actatatgta tattccgtat 3707341 cactacgggg tcaatcatgt acatcaagtc atgaaaaatg gaacaattgt tgtcaacagg 3707401 gagggagcca ttcttggata agtacccttt tctcagagag gccggatctt cgtttaaaga 3707461 ccgggatgtc acaaaaatga gcgacctgat cgcaacatgg gacggccagg acattaaggg 3707521 accggcgttg ataggtgtcc ccctatcaaa atcctccatc agtcattcag gcgcttcctt 3707581 tgcacccgga acaatacgcc aggctctgaa acattcatca gcctattctg ctgagcttgg 3707641 agagcacgtc gtatcagagc ttctatatga cctgggggat atcgatattc atgtcactga 3707701 tatcgtaaag tcacatcatc acattttcca aaccatgcac gctctgcttt cggatcatcc 3707761 ggattgggtg ccgctcatac ttgggggaga taactctatc agctactcca caataaaagc 3707821 gatagcacaa acaaaaggaa cgacagcggt gattcaattt gatgcccatc acgatgttcg 3707881 caatacggag gacggggggc cgacaaacgg cacccccttc cgccgccttt tggatgaaga 3707941 gatcattgaa ggtcaacatt tgatccagct gggtatcaga gaattcagca acagccaggc 3708001 ctatgaagca tatgcaaaaa aacataacgt gaacattcac acgatggaca tgatccggga 3708061 aaaaggacta atcccaacga taaaagagat tttgcctgtt gttcaagata aaacagattt 3708121 catttttata tctgttgaca tggatgtctt agaccagtcc catgcacccg gctgtccagc 3708181 gattggcccg ggcggcctct atacagacga attgcttgaa gcagtcaagt acatcgcaca 3708241 acagcccaat gttgccggga ttgaaattgt tgaagtcgac cctaccctcg attttcgaga 3708301 tatgacaagc agagctgcag ctcatgttct gttacacgca ttaaaaggaa tgaaactctc 3708361 cccattcaag tgatcttctg gcaggttgta ttttgggtat aagaaactca tctgcctaag 3708421 gaatggcagc taaaaggagg gcgagacagt gaatcttcag gagaacagca gccaacagct 3708481 aaaacgcaca atgaaaagca ggcacctatt tatgatctca ttgggaggcg tcataggcac 3708541 aggacttttc ctcagtacgg gctatacgct acatcaagcc ggacccggcg gtacgatact 3708601 cgcttatgta atcggcgggt tgatgatgta cctcgtcatg caatgtctcg gcgaattgtc 3708661 ggttgccatg ccggtgaccg gctcttttca aaaatatgct acaacattta tcggtccatc 3708721 taccggtttt atggtcggca tcatgtactg gatcaattgg gtggtgacgg taggctctga 3708781 gtttaccgca tccggtattc tcatgcagcg ctggttccct gacagcagtg tatggatgtg 3708841 gagtgcgatt tttgcagccc ttctttttat atgcaacgca ttttcagtta agttatttgc 3708901 ggaaactgaa ttttggtttt ccagcgtaaa gattgtcacc attattttat ttatcatttt 3708961 aggaggagcc gccatgtttg gcctgatctc tttaaacgga acggcggatg ctcctatgtt 3709021 gtcaaacttc acagatcatg gcgggttgtt tccaaatggc tttctcgccg tttttatcgc 3709081 gatgatatct gtgagcttcg ccttttccgg tacagagtta atcggcgtta cagcaggaga 3709141 atcagcaaat cctcaaaagg atataccgcg atccatccgt aatgtcgcat ggagaaccgt 3709201 gatttttttc attggcgctg tcttcatatt atccgggttg atttcatgga aggacgcagg 3709261 cgtgattgaa agcccgtttg tcgccgtatt tgcggagatc ggaattcctt acgctgctga 3709321 tattatgaat ttcgtaatat taacagcctt gctgtctgtc gccaactcag gcttatatgc 3709381 ttcgacccgt atgatgtggt ctttagcaaa tgaaaacatg atcagctccc gttttaagaa 3709441 agtgacatct aaaggcattc ctttaaatgc cttaatgatc agtatggctg tatcttgttt 3709501 atctctcgtt tccagtatcg tggcccctgg aactgtctat gtggtgatgg tcgcaattgc 3709561 tggatttgca ggagtcgtgg tctggatgag cattgccttg tcccaactct tgtttcgaaa 3709621 gagatttttg aaaaaagggg gggatgtaaa agatctgaca tttcgcacgc cgctttatcc 3709681 tcttatgcct atagccgctc tcttattatg ttctgcttct tgtatcggtc ttgcttttga 3709741 tcccaatcaa agaatcgcac ttttctgcgg agttccttgt atcatccttt gctatctcat 3709801 ctaccatttc aaaagaaatg ttacaaaagc gaaaaaaatc agccaagagg aatatccagc 3709861 cgatcacatc ctataattaa aaaagcacac cccgctcagc atgggatgtg ctttattttt 3709921 tattctgtaa ttaacgtatg aatcagcttc ggcgccttcg cttccgcggc gatgcggatg 3709981 ttgtcataga cttttgcgat gacttcatcg acgttttctc ggttagcgta aagcgttacg 3710041 agcggttccc ctttttctac tttgtcgccg acctttttgc ggagcatgat gccgacggct 3710101 aaatcgattt cgtcttcttt tgtggcgcgg ccggcaccta acagcatcgc cgcgacgccg 3710161 atttcgtccg cgacgatttc agagacgaca cccgcttctt tggcaggcac atcaatttga 3710221 tatgcggctt gcggaagctt agacggatcg tcaacaattg agctgtcgcc gccttggttt 3710281 ttcaggaaat ccttgaattt ctcaagtgct ttgccgtttt tcatgacttc ttccagcttc 3710341 gctctcgctt cgtccaatgt atcggctttt ttcgcaagca caaccatctg gctgccgagc 3710401 gttaagacaa gctcatgaag atcctcaggc ccctcgcctt tgagcgtgtc gatcgcttct 3710461 ttgacttcaa gcgcatttcc gatcgcaaag ccgagtggct gggacatgtc tgaaatgaca 3710521 gccattgttt gacggccgac gttatttccg atgcgtacca tcgctttggc aagttcagct 3710581 gcgtcttctt ctgttttcat gaaggcgccc gctcccgttt ttacgtcaag cacgatggcg 3710641 tccgccccgg cagcgatttt tttgctcata atcgagcttg caatgagcgg aatggaattg 3710701 accgttcccg ttacatcacg aagcgcgtac agttttttat cagccggcgt taaattgccg 3710761 ctttggccga tgaccgcaac cttgtcgcgg ttcacaagtt taataaattc atccttcgtc 3710821 agttccacgt ggaagcccat gattgcctct aacttatcaa tcgtgccgcc cgtatggccg 3710881 aggccgcggc cggacatctt agcaaccggc acatcaagag ccgcaacaag cggagcgaga 3710941 acgagcgttg tcgtgtcgcc gacgccgccg gtagagtgtt tatccacttt aattccttca 3711001 atggcagaaa gatcaatcgt ttcaccggag ttcaccatag ccatcgtcaa gtccgcgcgt 3711061 tcacggtcac tcatatcctg gaagaaaatc gccatagcaa gcgcgcttgc ctgataatca 3711121 ggaatgcttc catctgtata gccgttcaca aaaaattgaa tttcttcagt ggtgagttct 3711181 tttccgtttt gttttttgat gatgatatct accattctca tgtttggtca ccgatccttt 3711241 tcgattaagt tcagtaaatc aagcccacaa ttgctgctga taaaaagctg acaagcgtag 3711301 caccgtataa taatttcaag ccgaaacgag cgacgacatt tccttgcttt tcattcagtc 3711361 cttttacggc accggcaatg attccgattg aggagaagtt cgcaaatgac acaaggaata 3711421 ccgatacgat cgctgttgta cggccgctga aatggaaacc gttttgcgta agcgacgtca 3711481 tggcgacaaa ttcattcgat accatttttg ttgccataat gcttcccgca ttaacagctt 3711541 cattccatgg gataccgaca agaaaagcga atggagcaaa cacatatcca agaatgcctt 3711601 ggaacgaaat accgaatact gcattaaaaa tgccattgat caatgcaata atcgcgacaa 3711661 atccaatcag catcgcagcg acgacaaccg ctactttgaa accgtcaaga atgtattctc 3711721 cgagcacttc gaagaaggat tgtttttctt cttcctcaac acgaagcata tcctcttctt 3711781 ttgcaacctc gtacggattg ataatagaag cgataatgaa accgccaaat aagttcaaaa 3711841 caagcgctgt tacaacatat tccggtttca gcattgtcat atacgcaccg acaatcgaca 3711901 ttgatacagt tgacatcgca gatgcgcaaa gcgtgtacaa gcgctgctga tttaaaagac 3711961 cgagttcttt cttcaaggag ataaatactt ctgactgccc taaaatcgca gaagccactg 3712021 cgttatacga ttccaatctt cccataccgt ttaccttgct gagggcaagg ccgatatatc 3712081 taatgataaa cgggaggact ttccactttt gcagaatccc gatcagagcg gaaataaaca 3712141 cgattggcaa gagaacattc ataaagaatg tcgtttggtc cgcattcacc aagccgccaa 3712201 acacaaagtt aattccctct gccgcgtatt caagcaggta accgaatcct tttgcaaatc 3712261 ctcccacgag gaaattccct attccggtat tgaggagaat gtagccaaga ataaattgca 3712321 aaatgagcat aacaacaatt gggcggatct taattctttt tttgccgctg ctcgcgatcc 3712381 acgcgaggcc taaaaacacg attaaaccga taatcccaat caaatacttc atatgtgttt 3712441 ctcctttatt tgtattcgct tacaattact gtttcctcag aaaacggaaa gcagtctgcc 3712501 ttccgtcagc tcttaatagt tgtctccgcc tgatgcattt tctcctttta cgatagaaac 3712561 gcctgcgctg gcgccaattc ggcttgctcc ggcctctacc attgtgtcta catcttcttt 3712621 cgttctgacg ccgccagatg ctttcacgcc gatatcaggc cctactgttt tgcgcattaa 3712681 ggcgatatct tccttcgttg cgccgcctgt agaaaagcct gttgatgttt ttacgaaatc 3712741 cgctcccgca gacaccgcta aacggcatgc acgttctttt tcttcatcag tcagaaggca 3712801 cgtttcgata atgactttga caagcgcttt tccggctaca gcttccacta caccgcggat 3712861 atcagcttcc accacatcgt cttccttgtc ttttaaagcg gcaatattaa tgaccatatc 3712921 cacttcagtg gcgccttttg aaatggcgtc ttttgtttcg aacgcttttg tttcagttgt 3712981 attggcaccg agcgggaagc cgatgaccgt acaaacgtcg actccagttc ccttaagctc 3713041 ttttgcagca agctccaccc atgtcggatt gacacatact gaagcaaatt tgtatgtttt 3713101 cgcttcttca attagtttta gaatgtccgc tttttgtgta tgcggtttca aagctgtatg 3713161 atcaattatg ttggctaatg acatccttcg cacacttcct tttttgttaa gatatttttt 3713221 agcataaccg acttttgaac atatgtaaat tggtaattga aattttgttc aatgaaaggt 3713281 ttgaacgtgt cacaaatcat taacaagcgc cctcgcggta tgctggtcaa tgattaaaac 3713341 gttggcatat tttccggtta atgctccgtg aatggaagat acttttctgc ttccgccggc 3713401 aactaaaatg gagcgttcct tcagtctaag gtcttgaagc tcaacaccga tggtccggtc 3713461 attgatggcg ctgctgcaaa tattcccttt cgcatcaaaa aagcgtgaac aaatatcccc 3713521 gacggcctgt tttttcagca gggctttctc ttcttcgtta aaatatccga gccgaaacaa 3713581 cagcgcttca tcacggacag tcccgaccgt aaagagagcg atattcgcct gcttgcccat 3713641 ctcaatgatc cgttcaatat gacggtcttt ctccaccatt cgcttcacat ccgcattatc 3713701 aaacacgacg ggaagcggga gatagcgcgg catcgtttga aaagcctctg caaacagctg 3713761 aatcgtttca gccgaatacg tgtttacccg ggaatggctg atgccgcctt tcagctggac 3713821 gacctcgacg ccttttacct gcttcggctg catgttttgc gcgatttgat acatggtggt 3713881 tccccagctg acgccgacaa tgtcgccgtc ttttaccgtt tcatgcatat attctgcacc 3713941 atagcggctt aggtcatgtg taattcctgc ataatcgggt gtcggggaaa acacaacatg 3714001 cgcctcaagg agcccgtatt tctcttcaag tatggaaccg agcgcatcca aatcctcaaa 3714061 agggtccatg acgcgaatct ggacataccc tttttccttt gcatattgca gcagccggga 3714121 aacggttggc cttgaaatgt tgagctgctc agcaatttgc tgctgactgt agtcagactg 3714181 atagtaaagc cttgccgctt ctatgcttaa ttgctgtttt tcccgatcca ttctgcacct 3714241 ccctgtggat cagtcctgat aaaactgctt ttgatttgct tttattatac aggctggcgc 3714301 cggctttcat ccacctgatt tctaagaaac tgaaaaacgc tctgggcgcg gacctgccca 3714361 gagcttactt ctcccaagtc atatgctgat aaatgccttt cataatggcg tacattccat 3714421 ataggatcag gcctaatgcc aatatagaca gaatcaattt gccatgcggc tgctgcgcga 3714481 gttctgcgag cgcgccgtca aagcctcttg tgtcgtcggg atcagcggtc atggctgtct 3714541 tgatgagaaa atagccgata gccgagaaaa taatggcccg ggcgatattg cctgcgcgtc 3714601 ctgtgttttt cgtgatgcat atcatctgtt tgttcatttt tgatgtatcg aattctttca 3714661 taaaagcagc ccgaacgcct ttcataaatt gaacaatcgc aaatacgata aaacccgcac 3714721 ccgtaagccc tgtgagccat tggccgaacg gctgcgccaa tacataagcg gaccacgtct 3714781 gttctgaagt gccgccgtcc ccttggccaa acacaaatcg caaggcattc caagcgatgg 3714841 atgtgtaaac agcggcactg aaaaagtttc ctattctccg cgacaggcct cgcctgctgt 3714901 ttccgtgccc ctccgtgtcc ttgatcgcgc ttaacaccat ccagatcaca tagccgataa 3714961 ggccgatgcc tataaaaaaa agcaatagtg acccatacgg catgcgtgat agcgtttgga 3715021 gagctccgct cgaatctttg gcgcggcctg ccccggcagc cgtcataaaa gccaaaaccc 3715081 caagcagaat aaaaacgccg ccgaatgcaa aataaccaag cctcccgaat cgtttgatcc 3715141 aaggcttggt ttcctgtttt atttttgaca tgtaccggtc tttcaccgcc atgtgtccaa 3715201 ccctctttca cagaaatctt tactgtaaca ttcccgattg aacaaagttg aaacagctcc 3715261 tgcctcagct atggctggct gagatacgtt tttgctgttt agctgattgt gcaggtgtca 3715321 tccaagcagc cgctgcggca gctgtgactc cgcctgctaa tttcccaatg atcatggccg 3715381 ccgccatttc ttttttcatt ccagctacaa aaccgagatg gctgccgagt acaaaggcgc 3715441 cgctgaccgc aaacgcgaca ttgatgacct ttcctctcgg cgtcatatcc tttaatgaag 3715501 ccagcattgg gatatgatgc gccaaagagg tcactaagcc tgctgttgct gtctcatcta 3715561 aatgaaggca tttccccaga gcctgaagcg gttttttaaa ggtttttgta ataaatgccg 3715621 tcatcgggaa cgcccctgcc agagcaatgg cgatggtccc tgtcgtttgt atccctgtct 3715681 cgacattctc cattcccgga atcagcacaa tgccggtcat cgtttcaaca gaaacagctg 3715741 caagcccgat aatcgcaacc atactgaccg ctttcccgaa gagatgaaac aactgaatca 3715801 ttctgtcggt gtatcgccat aacccaaaag cgatgacagc agataacaga ctcgggatca 3715861 gaagattttt acctatcatg ccgatgtcaa agcctgcgca taatccgccg attaagcaac 3715921 cgatcggcac tgtgcacagc ccgattaata tgcctttcgc aaaatacgga tgatcctctt 3715981 tttcgatgat gccaagagcg acgggaatcg tgaagacgat tgccggcccc atcattgttc 3716041 ctaaaaacac ccatgaaaac agcccggcct gcggatcttt cgccatttct ccagccagcg 3716101 catatcctcc catatcaatc gccaaaatgg tgttcgcaaa ggaagaagga tccgcgccaa 3716161 tcgctgtgta aaacggagca acaatgggaa tcaagattgc tgccagcacg ggcgccagcg 3716221 atacaattcc gatcatggac agcgccagcg gccccatagc cttaaagccg tccgcaaacc 3716281 gctcgcctag cccccatctg tttcccaaac aataatccgc tgctccccat agtaaaaagg 3716341 cagccaaaat gaatacaacc gcgtcattca ccgtcatggt tttctccttt ttcaaacgta 3716401 tgattggttt tatcatatca tctgaaatca ccgaatagag ttgatcttat tcaatatgag 3716461 ctaaaaattc ttttatatcg gctttttcaa cggctgttat aatgcgtcgc gctttttctt 3716521 gcgggaccgt taatgtcaat ttttctatta tgtcttcttc agacagctca tttcctggtg 3716581 ccccttttgg gcagtccaca cgcgcttcgc aaatccggcc gtctgataaa taggcccgga 3716641 caatcgtgaa acggcctttt ggaacggcat gaggagccgg ctgaatagca ttgtcatata 3716701 cgcgctgaat tcgccccatt gtcgtttgaa ccccgtttgg gatcggctgg ctgctgaaat 3716761 gttcaacggt caggccgtgt ccatgcaaag caagagcaat cacatattca acgctgaaac 3716821 ggccttcctc tccagctttt ggagatcttt ccgtcaatgc agcatctccg cctggcggaa 3716881 atatcacttc aatacgttcg gtattggcag cagaaatggt ttcttcggag ataagctgtc 3716941 gtaccgcatc tgcagcatgg tgtgccgcgg aacaaaatgg atagatttta aaccatagac 3717001 ccggctgcac aattctccac ggtgcccccc aatcgtttag caaagtgtgt tgtgctttct 3717061 caacgtcacc gtacagactg aagaaaccag tttctccatc aagtgccgtg cgggacccgc 3717121 caaattctga ttgggccagc ttaacggcca gcaagccagc ctgagccgcc aaaccggcgt 3717181 gcagcggttt catttctgtt ccaaattgca ccctcatccc agcagattgc gtagccgcaa 3717241 aaccaattgc tttttccaac tcttcctgag tcagctcctc agcataacct acggcgcagg 3717301 cagcagcgat ggcaccaagc gtacctgtat tatgccagcc cttctcatag tggcggctgc 3717361 caattgattc tcccagccgt gccatcactt caacaccaac aacataagcg ccaagaagcc 3717421 gctcgtcatg tccgcgagcg gcagaagcaa taagggccgg tacgatgact gcactggggt 3717481 gtcctcttac atcggagtgg acatcatcaa aatccaatgc atgggcgata aatccattga 3717541 gcatcgcgga ttgtaatggc gcggcctttt tgccctgtcc gataacagga acaaggggcc 3717601 ggcctccttc atcctctatc agacggagga gcttttgaat tcctttatct tctcttcctg 3717661 cgaatgaagc ggcagtaaaa tcaagtaatc ccttttttgc ttcgtgaatc gcgtcaactg 3717721 aatgctcagg ttgtgacgtt ctcacagcct ctgcaagacc tgctgtcagc ccttgtttgc 3717781 tcatttgatg gtctccaata caataaccgc cagctccgca aagtattgag aggcaaccgt 3717841 aagggcttct tcatccagtg taaaggccgg atgatgccac tcctccgtcc cgttcgttcc 3717901 catccagaca aaaaatcccg gaatcttctc ttgatacaga gcgaagtctt ctccgcccgg 3717961 agactgctca gcgtgaacgg tttgatagcc aagccgtgcc gcagcttcgg atgccgcatt 3718021 caaaaatgtg ccgtcattct gaacggaagg caaataagga aaccacttga attctgcttg 3718081 tgccccatag cccgctgcaa ttccttcagc cactcgtctc atatgctcgg gaacagcctg 3718141 cctcgcttct ttttgaaagg ttcgaaccgt cccctccatt tcagcttggt ctggaattac 3718201 gttccacgag gtgcccgcct gtactcttgt gatactgacg actgcgtttt gcagtgagct 3718261 gatattgcgg ctgaccacag attgcagccc gctgatgatt tgtccggctg cagcgattgg 3718321 atcaatactg ttatttggga tgccggcgtg cccgcctttc cctttgatga cgatctcaaa 3718381 tcggtcaaca cttgccatga gcggaccttc ctttacacca atggtcccga caggcagatc 3718441 cggcttattg tgcatgccga aaatcgcaga aacgccatta agtacgccag cttctagaac 3718501 ctttcttgct cctgcggcaa tttcttcggc cggctgaaag ataaagcgga ctgtaccttt 3718561 cagctcggcc cttctttgat tcagcaacat cgctgtgcca ataatagaag cagtatgaaa 3718621 atcgtgtccg cacgcatgca ttgtgccatc aaccttagat gcaaatggaa gattcgtctg 3718681 ttcttggatc gggagcgcgt caatgtccgc tcgtattgct atcacggggc cgtcttcccg 3718741 tcctttgatt tctgcaatca caccagtctt caattgaggg acatcaagta tttcgatttg 3718801 ctcctcctca agccaacggc ggattttttt cgtcgtttca acctcttgaa atgacagttc 3718861 aggatgttca tgaagatcac gccgcatatt gattaaacgg gtatgaaacg ctttgtcggc 3718921 cattgttctt ctccccttct tatataagct ctgcaggctc tcccacctgc ttgataaatc 3718981 gtttcgtccg ttcgtttttc ggatggtcaa acagttcctc tggcgttccc tgctcgataa 3719041 tatggccgtc tgccataaaa atcacttgat cagcaacctc ttttgcaaac gccatttcgt 3719101 gtgtaacaat gatcatcgtt gtttgttttt ccgcaatgga cttgatgacc tgaagcaccc 3719161 ctgtgacgag ctcagggtca agcgctgacg ttggttcatc cagcaaaatc gcatgcggat 3719221 tgaccgcaag cgcccgcgca atgccgattc gctgctgctg gccgccggac attgtgattg 3719281 gatagctgtc agccttatgc tccagaccga cttgtttcag aatctccatt ccaatacgtt 3719341 tcgcttcgtc gcgtggttta tgttgagcca cgattaaagc ttctgtaatg ttttgcagag 3719401 ccgttttatt tttaaacaga ttgtagtttt gaaagaccat ggccgtttgc tggcgaagcc 3719461 gatgtgcttc cttgcgtgta aacttttccg cattcagttt ggcttctccg atttcaataa 3719521 ggccttgatc cggacgctct aatagattta agcaccggag aagcgttgat tttccggaac 3719581 cggacggacc gatgattgcc accacttctc cgcgtttcac ttctagatcg attccgtcga 3719641 gcacgacgag atctttaaac gctttgcgaa tattttttac tgttatcaac tgatttcacc 3719701 tctaagtccg gtatggcttg ctcatggcac gttcaaacaa gtcctgcaaa atgctgtaga 3719761 taatggtaag aacccaatag acgatcgcaa ccgccaaata cgtctcaaaa tatttgaggt 3719821 ttcctgaagc gtacatcttc ccttgggcga acatctccat gacccctaat gtaaaggcca 3719881 gtgacgtttc tttcaggagc ccgataaatg tattgcccgt tgccggaatc gcatttcgga 3719941 tcgcttgcgg caaaataatc cgtctgtatg cctgaaattt tgtcataccg acagacaggc 3720001 acgcctccag ctgcccgtca tcaacagaat tgagggcggc ccggaagatt tctgccaaat 3720061 aagctgcgtt ttttaagctt aacccgatga tggcagctgt gagagctgtc attttgctca 3720121 tctctggaaa tagctgcggc agcccgtaat agattaagaa cagctgtaca agtgtcggca 3720181 cgcctcggaa aaaggatata tacagctttg acagctgatg aagcactgga attttgtttt 3720241 ttgtaatgag tgcgagaata agtcctccga taatggcaaa aatcatagct gctattgcca 3720301 taaacaaggt gatcggaagg gcctgaatta aagtcgggaa cgctgatatc atgaattccc 3720361 aatcaatcgt gttcattctg gtgagtcacc gccgtttctt aatgcttctg ttctactgtg 3720421 atatcttcat taaagtattt ttcagagagt tttttcagtg ttccgtcttt acgcaattca 3720481 tctagggcct tattgacttt tttgcggagc ttgtcgtgcg catcgtcctt ggcaaatggg 3720541 aatgcaacct gttcgtaaac aatcggatct cctgcaagct ttaatggcaa accggtcttc 3720601 ttgatttgcg cgatcaatac agttcggctg ttgacataag cgtctacacg gccgtacgca 3720661 acatccttca gcgtaccctc ttgtgtttcg tacgttttga tattgatttt tttatcagga 3720721 tctttgcttt caaggttttt cgcgtggttt gaaccgagaa cggctgcgac tgtcttgcct 3720781 tttaaatcgt ctactgattt gatgtctgta ttgtcttttt tgacgacaat ctgtgttccc 3720841 gcataagcgt atggtttcgt aaagttatac gtttccttac gttcgtctgt cacagctacc 3720901 tggttggaaa tggtgtcaag cttgcctgtt tgaagctctc ccatcagccc gctgaattca 3720961 agcagcttcc agtccagttt catgtcaatt ttcttagcga ctgcttccat cacttccacg 3721021 tcaaagcctg tcagctttcc gttttcttta taagcaaatg ggtaactttg tcctgtcgca 3721081 ccgacatgaa gcacattgtc atcctcttta ctgctgctgt ttccattgcc gcaagctgag 3721141 agcaccgcta ataatgcagc aacgaccagc actgtccatt ttttcatctt catttgattt 3721201 tcccgccttt tctattttta tagatcatgt cgcaattgtt ttttcatata gactgtgata 3721261 tgcccttttc caaggtcttg ttcacctgag cggacatatc cttttcgttc gtacatctca 3721321 atcagccacg gatgcttatc cgctgttccg agtgagacaa acggaacctt taacgtatcg 3721381 cgaaggattg tttcctccag ccattgaagc agctttgttc cgattccttt tttaccggtg 3721441 tcggggtcca cagcaaacca ccagatatgc ggaacgccat acggtcccgg ctgttttccc 3721501 caaggcattc tcaaggtgat ggtcgcgatg atccgcccgt cttcttccat gacgtagcaa 3721561 gcattttccc gaatattttt cagcaccaaa tccaaatccg catgagcagc agcaaaacga 3721621 atgccgagct ttcgaatcgg ttcataagcc cgcaatgtca gctcgagaag ctgttcggca 3721681 tcacgttcaa ctgcaaggcg gtatcgtggc ttcatctagc gttcctcctt actttgcata 3721741 gcggtttacc ggcttttcca aaccgaagtg ctctcgtaat gttgtgcctt catattcttt 3721801 tctgaacacg ccgcgctcct gtaaaatcgg aaccacttga tcaacaaaca cttcaattcc 3721861 ttctggaaga agcggaggca tgatgttaaa cccgtcacac gctttcgtat ccacccattc 3721921 ctgcatcttg tcggcgagct gctccggcgt gccgacgaag atatggtggc ctctggagcc 3721981 tgcaacgtat ttgtaaagct ctcgtatcgt catattgtca cgttcagcca tctcctgaac 3722041 aagcttgaag cggctcttca ccgcattgga agcttcggcg tcaagcttcg gcagcggccc 3722101 atcaagcgga tatgccgaca aatcaattcc gcctaagtaa ttttggagaa tttgcagacc 3722161 gacagatggg ataatcagat cttggagctc cttgtatttg gcttgcgctg cttcttctgt 3722221 atcggcaatg attgggaaaa tacccggcat aatggcaatt ttttctggat cacgtccgaa 3722281 ttccgcagcc tgttctttaa tggattgata aaattcttga gctgattcca ggtggttttg 3722341 tgctgtgaag atcacttcgg ctgttttggc agccagcgct tttccgtctc ctgatgatcc 3722401 tgcctggata atgaccggct ggccctgcgg ggttcttgaa acgtttagag gtccgcgaac 3722461 cgagaaatat tctcctttgt ggttcagctc atgcattttt tctttgtcaa agaattcacc 3722521 cgtttcttta ttacggataa aggcgtcctc ttcccatgaa tcccaaagcc cctttacaat 3722581 ctcgacaaat tcctctgccc gctgatagcg caaatggtgt tcaaggtgct tttcaccgct 3722641 gaaattcagc gctgttgatt caatagatga agtgacgacg ttccatccgg cacggccatt 3722701 ggacagatga tccaatgacg caaactgtct ggcaatatgg aatggctcgc tgtatgtagt 3722761 ggaggctgtt gctgtcagtc cgatttttga tgtgacctgc gccaaagcag agagcagggt 3722821 gaatggctca aaccttgtta atacatttgg atgtgatttg ctgtcaattg aaaggctgtc 3722881 cgctaaaaac agcatatcca gcttgcctcg ctccgctgtt ttcgcaagct ctttaaaata 3722941 atccaaattc atgctcgcat ctgacggcgc gtccgggtgc cgccaagacg caacatgatg 3723001 gcctgtacct gctaaaaata cccctaattt gatttgtttc tttttgcttg tcatggcgat 3723061 actcctttta tcatgttttt aggctgaata atccgaaaaa taaactccta tattcctagt 3723121 cgtttaatat gaataaatca aaatgtacct ttgtcttgga cgtttgtcaa tgagttaaga 3723181 ttaatttttt ctattcaagc gaaaagaccc ttgcgtgacc atgagggaac ggcattgatt 3723241 cattcaacta gtgcaacctc tatatcggca agaaaactga gtctaatgaa gcaaagactc 3723301 agttttcttc caataatttc atataagatt tcgccatttc ctttgccttt tcttcgcttt 3723361 tgcaaaccgc ctatccattc agacgccgta acgattgtat aaaaaaacag ctgactccag 3723421 atattcaaac cggaatcagc tgattgatgt gaattaatta agctcatgaa tactctcttc 3723481 tgctttagcg gaaaacactt taggctccaa acagtcaagg tcttcatgaa ataaatttac 3723541 tttttggatt tgccgattgt catagtggtg gaaatagtag tttccagttt cgttgcacat 3723601 cacggaagta tattgcgtat aatgaatttc gtcttcttcc gttatcactg cgccctttgg 3723661 tatcgtcata tttgccaaaa tttgaaaagc ggctgttaca cctttcgttt catcggccgc 3723721 cggctctaga tgttctttca aataaacagc tctgacaaac cgggaaggcg gtgtataatc 3723781 ccccggcaga ccaacagttc ctaagccttg gccaaaagca gaaagggcta atccgcccat 3723841 ctctttgctc tctaattgct tcggtctgat tcctgtatat tgctgcagat tggttacatg 3723901 ccatataaag tcggggctgt tcgtcatgac accaggttga ttatcataga ctttgaggcc 3723961 gtctgctctt ggttctatcg tcaggtttcg gcccgtccgg tctgacaata tccagtgaag 3724021 cggtaaaact gtatccaata gatctaattt tttctctaca atcgttaaag atcgaatctt 3724081 ttcttttacg tcttccaaag actgacagac tgacagcacc catgtcacaa actcatgcgg 3724141 gacaatgtga acggtatctt cccgtatcgt tttttcgtac tccgcatagc ccggaaaata 3724201 aagcgccgca caagataaac cgctttcatt aatgccgtcg gcaaataata tatttccaag 3724261 ttttctcccc ataccgataa acgcgtactg tgtctgatgg gcccttccgt cagcttcact 3724321 gttccagctg taacggcgcg gatagagaat cacctctgtc cccagctgaa atgcaaaatc 3724381 cattgttctt gctaatacat gtttacggtc agcagtttcc aatgtaagac ttgtgcacat 3724441 ttgatcagtc cccttttcaa ttcagattaa tatcatacat attgtgaacg aattggtttt 3724501 atcagcataa cgaaagtcaa atcgattcgt caaagaattg acattacatc aaataaaacg 3724561 aaaaaatcca gcctttagaa ggctggattt tttattattt agccaaaaca agctcgtgaa 3724621 tcgcatgtgc aacgccatgt tcattattgg agcgtgtttg aaagtttgct gcttccaata 3724681 cttctgggat ggcgtttgcc atggcaaccc cgcagcccgc ccattcgatc attgtcaggt 3724741 cgttcccgtt gtcgcctatg cacatgactt ccgcctgttc aattccaagc agctgagcca 3724801 gctggcgtac agcatttcct ttgctggctt ccgagtgcag aatttcataa aagaaaggcg 3724861 cgcttctgac cattgtatat ttttctctca cgtcttttgg aatcgatgta atgacgcggc 3724921 ttaagttctc cggtttatca ataaacatca ctttcgggat gaggatatct tttggcacct 3724981 cgtcaatctt gcggaaatga agcggcacct gtgtcacata ggattcgtat acggtaaatt 3725041 cgctaatatc ccggttaggc gtatacaaat tagatgagtc aaagaaatgc atcggcgtct 3725101 tcagctctaa gctcaggtca tataatgaag tcaaatcatc ataaccgaga gacagctctg 3725161 agaccacttc atttgtatgc gtattttgaa caagtgctcc attatacgca ataacatagt 3725221 cgccttcttc aattaaattc agttcatcta aatatctctg cacacccccg ataggccggc 3725281 cggtgcaaag cacaattttg acaccttccg cttttgccgc gtgaagggcg tcgcggacct 3725341 cctctgttac ttcatgatga tcatttaaaa gtgttccatc catatcaatt gcaattagtt 3725401 tgtacatcct gcatctcctt catgtcgttt tcaggctata gtcccatcat atcgtttttt 3725461 ctttttgata ttcaaccgga agagatggtt ttctccggat tctgtttaga cgccgccctt 3725521 gtcttcggat acgcaagcgc ggtttccgct ttctttctgc cttgacgccg ttttctgctt 3725581 ttttctgttt catcagcaga aagccggcag ctagaaaagg aatgccggtt atattcaaga 3725641 tggcaagctt cacacccgcc gcgatgaaaa agaaccccca tgaagatgat ggattccgtc 3725701 tgatcatgac gtaagccgcc atttccagaa cgatcaggat ggcatgaagc actatgccat 3725761 aaatcagcaa tacaagggca aaaaacaaaa cataattcac gattgcccct gagtacatca 3725821 tagcgcgcat catttgtata aacgataagg actgcatgga gccgctgatg acattagggt 3725881 tatagatcgt atagtcacta aataaatgtt tgactttgag aaaagcccat aatataaata 3725941 tccattgaat gatatgtaaa acaagccccg ctgccaccag tctttcagct ttttgatttc 3726001 tcatctttct cctccctgcc ggtctttgat tcgattcttg tcatcgtttt tctctgtcca 3726061 ttttgctccc atatcaatgt cccgttttct cctcttttca gcgtgctttt gagcggataa 3726121 taagggccga ggtactgaat ctcgatagac ccgtcagtgc tttgggaaat caccttgtat 3726181 gccataaaag gcagctgtac ctctcctctt ccttccatca cttccgtttc cacaacctcg 3726241 tcttcggtaa atgtgactgt tgctgatttc acaccgtccg ttggcccggg ggcacgcccc 3726301 tcatcccacg ttccgtaata aaacggcgtc tcttcttttt gctgctggca gcccgatacc 3726361 atgatgcata cagcaattaa aaacaaaatg ccatatttgt ttctcaaggg gatcaccatt 3726421 ctttcctcct tttttgggcg aatgccgtgc cactgtgcca atgactacat aagttataag 3726481 gaattcaccc acaaggagac tgatcacatg aacccttatc aatattacag ccctcagctg 3726541 cctcagcagg aaccttacta tagccactat gagtacaatc cttatccgca gcaggatgta 3726601 tacgatccat accaaatgga cagacagccg gcattggaaa gaagaatcgc agcacttgaa 3726661 cggcaaaatg aacagcagtc aagagaatta acccgtctga caaacgaaga ccgccgtcaa 3726721 aatcgggaaa ttgcacggat tgccgaacag gtcaatcagt taagccaggc tgttgaacgc 3726781 catacacgcc gcctaaatcg gctcaatcag cgcctccgta cagtagaaaa ccggctgaat 3726841 atcccattta ctgcagggga aggcggtttc tgagcgaaac aaagaaaaaa agcggaatac 3726901 gattctccca tctcagggtt tcgttttccg catttcttat atgttaaaac ggaacattta 3726961 cataaaaagg gtttgtaccc agtatacaat ctttaccgtt ttcattcaaa gatagagggg 3727021 ctgaggaaaa taattgtagt tcctctttga cggaatttct tttcattcaa gttgcatgat 3727081 aataccgact cacgtcaatc gatacatgga gggatcattc atgcataata cacaacacgg 3727141 cttgcagcag ctgaaccaat gccgccaaac tgctcagcag ctcattcagc aaacacagca 3727201 aagcagccag caatatcgcc aaatgcttca tcaggaacag caaaacatcc aaatgctgca 3727261 gcagattcta aaccacgaac aacaagctgc acataccatt cagcaagcac tgcacgggca 3727321 tgacatggcg attcaaaagt gccagcaggt tgtcaacatg tgcaaccaaa tgcaacagga 3727381 acttactgga caatccagcg tcatgaatac gaatgtgtct acacttccat tcggccaaaa 3727441 cacgacattt cagcagcaat cctaccagca gtaacatata aaaagctcaa cacaatgcga 3727501 gtgttgagct ttttttctta ctgttctttg cgaatatgta tatcctgaat agactgtttc 3727561 ggtgcatgaa atctgctctc ggcttcactt cttgcctcgg caaaagcccg cgcctccaca 3727621 tgatctttgt agacatccag ctgaatcaaa tacagcgggc gcactttaaa tccatgaata 3727681 atggttaccg cccataacgg gaccacaata aaaacaccgg gcagatcggg caaaacaaaa 3727741 ccaaacgcaa aaatgaaaaa ataaatgatg ccgtacatga tccactttct atttctaacc 3727801 ttgatgccaa taaataaaaa ggcaaaaaaa ctggtaatgg caaaaggcat gaaaataaac 3727861 agcatccacc agctatgcag ccattcccaa gcggcacctc tttttgtaat tcccatattt 3727921 ttctcctcct atttacctat aataatcgat taggcacacc gcgtcaccca taaacgggaa 3727981 aaactttctc ccttaaaaat agtgatagac ggagaacagg tttcttgcta tattattaat 3728041 tgataatgat aatcattact aatctattga gatacatagt gggagggttc ttgatgaaaa 3728101 agaacatatt gctcgtgggc atgcttgtgc tgcttctcat gtttgtcagc gcttgcagcg 3728161 gcacggcttc taaagggagc tcaagcgatt ctgcttccga aaaaacagaa atgagaacat 3728221 acaaatcacc aaaagggaac gtcaacattc ctgcacatcc gaaacgcatc gtcactgatt 3728281 tttatgccgg tgaattgctg tctgtcgggg ccaatgtggt cggctcaggc tcatggtcat 3728341 ttgataatcc gtttttaaaa tcaaagctga aaaatgtgaa ggatgttggt gatccaataa 3728401 gcgttgaaaa agtgatggag cttcagcctg acttaattgt tgtcatgaat gaagagaatg 3728461 ttgataaatt aaagaaaatc gctccgactg ttgtcatacc ttataacaca gcgaaaaacg 3728521 tagaagacac agtcagcatg ttcggagata tcgccggagc gaaagaccaa gcaaaatcct 3728581 ttatggctga ctttaacaaa aaagcggaag cagctaagaa gaaaattgcc ggcgtcatcg 3728641 acaaagatgc aaccttcggc atttatgaaa acacagacaa gggcgaattc tgggtgttca 3728701 atgacaatgg cggacgcggc ggccaagctg tatacaatgc acttgggtta aaagcgcctg 3728761 aaaaaattga gcaagatgtc atcaaaaaag gagagatgaa acagctctct caagaggtta 3728821 ttcctgagta tgccgcagat tatatgttca ttacggatta caacccgaaa ggcgaaagca 3728881 aaacactcga caagctggag aattcctcca tttggaaaaa tcttgacgct gttaaacata 3728941 atcgcgtgtt tatcaatgac tttgactcgt tctacccgta cgacccgatt tctgtcagca 3729001 aacaggtgga tatcatcacc gacatgctga tcaaacgggc cgaagaaaat aaaaaataaa 3729061 aaaacggcac agtcatgacg ctgtgccgtt ttttatgatt cactttaatt ttgactgtac 3729121 ggagtccggc atatcttcaa acttgacttc ttcccaagtc tcgacatact ttcctttcgc 3729181 cttcaccttc aaatacgcgt tcttccgaag ctctttgccg gcgaaaaagg tcacttcttc 3729241 ttttttcccg gatgcattat atccgtctaa tgtatattca gtaccgcccg gactaagatg 3729301 tctgccatct cgatcaatct gaacatagac atcttgctgg tgaataaacg gattaaatct 3729361 gtctgtaaca tcgttatgaa aaaagagaag cccgcatatt acggcagcag ccgccaagac 3729421 ggccaggatt gccattgctt ttttcatctt tgcactcccc ttacttgttc atttttttca 3729481 aatagcttga ccgcaccgcg aggaagaata gaagctgaaa aatgaaaaac cctccgatgg 3729541 tgagactgag cggccccgct acatcggaat atccttccac agccaatgtt ctcaaggcaa 3729601 acagtgtatg catgacggca atgacaaatg gaaagaagaa aagaatcgcc aattgtattg 3729661 tcacgctttg cgccatttct cgctcactca ggccgatttt ggccagtgaa cggtagcgct 3729721 cccggtcttc atctaaatca gtgaacagcc tgaaatataa gaaacttgct gccgcgacaa 3729781 agaatacaat tgcgataaac aggccgataa atagactcag gctcggcagc tgcaccgtat 3729841 catagtaagt ccccgctttt gaagcaaaat cagaatgcac gtcgatataa ttgccgtaaa 3729901 tctcattttg caaggattgg ctgatctcaa gactgtcttt ccaatgatca tagctgtagc 3729961 cgtataatga cgctttatca ccgagtgatt tcagctgatc aaaggtttga tcattcaccg 3730021 cgatgatagc attcaatgag atcagcggtt ttttgacttc ttttaccgac agtttttgat 3730081 cagacagctc ccctttttgg ttcagcagct tcagctgatc cggcgcttcg tttttgaaat 3730141 tgcggtcata cgttcccggg aaatagacag cctcgtcttc tttcaggccg ttcactttga 3730201 catggaagta ttttgccgca tccgattcac tgatcatgta aacaggggga acagtttctc 3730261 cttcctgata gcgaacatag gaaacatcta ttttgtcttt cgtatacgta aaaccgtgtg 3730321 ttttcagttc atggtcaata tctttcaaat gagtctgttc ttttggattg ttgctgtaag 3730381 ataaatactc catttcataa gcggactctt ccgctccgac ggtcgatttg tacattgcga 3730441 gcacgcctgt cgcagtaaac gcaaccgcgg aaataatgct gacaataaag aacaggcggg 3730501 cgttgtcttt tagacgatag acaaggtcag aaacccaaat gatgtttttc ccgcgcagat 3730561 aaaaggtttt ccacttcttc agcgcgcgca gaatccatat gctgctttgg ctgaaaaaga 3730621 aatatgttcc gataacggtg agcagtaaaa tgataaacgg ttcggccccg tggacattgc 3730681 ctttaagaac catgccgtac ccgccgcaca gacaggcgat gccgaataag gacagaagca 3730741 cggacggctt aggctccggt ttaaccttgc cagtgccctt tattaatttg ataaccgtat 3730801 ttgatctgac aaaaaggatc gtaaactgcg ataaaaagaa aaataagagc agaaatccgc 3730861 aggccgtaat accgagcgct ttccaaggca tatacaaagg cagcgcgtcc atttctaaaa 3730921 tataagcgcc gaccgtaaag aacgtctttg aaaaaatgaa tcctccgata ataccggctg 3730981 caattgacat gacgccgatg atcatatttt ccgcagtaat gagctttctc agctgccccg 3731041 gcgtgatgcc ctgcatgagc agaatgccga attctttatt tctcgatttc aaaaatgcat 3731101 taaccgaata cagaacaaat aagaaagaaa aaacaaagat catccattcc gcggcggtta 3731161 agcctttttt ggcgatgtta ttcaggtagc cttcctttaa tgccggatga aacaggaaca 3731221 tcgcaaaggt aaagaaaatc aaaacggaaa aggcgctgct taaaaagaat gcaagatagg 3731281 cccttttgtt tctcgtgacg tttttataag cgaactgaag aaaggtcatt tgcgtttccc 3731341 cccagcatag acagcacatc gagaatttgt tcataaaata cttggcggtt ttccccgcgg 3731401 taaatctcat taaacagttc gccgtctttt ataaagatga cgcggcggca gtagcttgcc 3731461 gaaaccggat cgtgggtcac catcaaagcc gtgacatgat catcccgatt caggctctgc 3731521 aacgtttcca tgacgtcttt tgtcgctttg gaatcaaggt ttccagttgg ttcatcggcc 3731581 agaatgagtg acggcttatg aatgaccgct cttgcgatgg cggcccgctg gcgctggcct 3731641 ccggatactt caaacgtccg cttgttaagc aggttttcga taccgagctt tgccgcgatg 3731701 ccgtgcagtt tttcttccat tacagacggc gcttcttttt caagcgttaa cggcagcatg 3731761 atattttcac cgatcgtcag cgtatccaga aggttgaaat cctgaaacac aaatccgagc 3731821 tgcttgcggc ggaaatgagc gagctttgtc cgcttcaggc gatgcgggtt ttctccgtta 3731881 atcaggatat cgcctgaatc tggacggtca atcgttgaaa tgatattcaa aagcgttgtt 3731941 tttccggacc cggacggccc catcaccgcc gtgaactcgc cttcttctat tgaaaatgaa 3732001 atttgcttta aggcctgata ggacacttgt cctttatagg ttttatttat atgtttgact 3732061 tcaagcatat tcgccatgaa aatcctcctt atggttttat tcttgttgat ctgggctgct 3732121 ttcatgtagt gccgggacgt tcaacataaa aatccccttg acataaatcc atgttatcaa 3732181 ggggaaacaa agcgggctat gttgttttct taacgcagcc ttacattttt gtaagaaatg 3732241 aaaatcgaac tgatgtccct tcaccgggag acgagctgat gtccaccgta tgattgagct 3732301 tatctgtaat ttctttgacg agatggaggc cgattcccgt agattcttgg aaacgccgcc 3732361 cgttttcacc cgtgtaataa gggtcaaaca cccgcttgat gtcttgtgag ggaatcccga 3732421 caccgtaatc tttgacttca agcaccgtcc tgtcttcatc gcagaagaca ttcagctcaa 3732481 gtctgtcact cttgcccgct gaatacttga ccgcatttgt gaccacttgg ccaatcgcaa 3732541 atttgagcca tttggcatcg gtgtaaatct gatgatcatc gcaaacgttc attttcggat 3732601 aaacgcgata ttgaataaaa aatcgtttat agctttgaat aactgattgg agaagctcgg 3732661 acagggaaac cgcttcgatt ttaaaatccc gttcaaacag gtcgagcctt gaagaataaa 3732721 gaagcgtctc cagcccgaat tcaatctgcc ggacttcttt tttgatttgt tcaaaaacgg 3732781 gctcatcctc ttcttgaatg attaaattaa tgaccgacag cggcgtcttt acttggtgca 3732841 cccattgatt catatacgtc acccgcgcgt caagcttggc ttcggtctca tggagcttct 3732901 ggtgctgcag ccggatcagc tccatctgct tttcatacag ctctgaacag aacactgaag 3732961 aaccgagata cgggatatcc gtcccttcct gccccgagct gagccaatga tacacgccgc 3733021 ggtctttgta ccagcgatag gcaagatagc ccgccaaaat aagaagctgc acgcccaata 3733081 tgtaaaacaa gtgagaaaaa gaatgaagac ccgcaaacca gtaataaaag aagacaaaca 3733141 gcccttgaag gagaaaaagc agaatcagca ctgcatgaga ccggagaaac agcttcatga 3733201 ctgcgccctc agctggtagc cttcgccccg caccgcttca atagaaacag gcgcattcag 3733261 ctcccgcagt ttttttctga gccgcgtgat atacacgtta agtgtattat catcgatgaa 3733321 tatgtcggtg tcccacgtct tttccatgag acggtcccga ctcgtcacct tttctccccg 3733381 ctcaagcagc acttccaaaa gcttgctttc ttttttagaa agctcacttt tttcatcctg 3733441 aaaacgcagt tcaaaccgtt ccacaaagag ctgaacgccg gcatattcaa ccactttctc 3733501 tccctgcttt gcggcgtact ccccgtacgc cctccggatc tggcttttga ttttcgcaag 3733561 cacaatatca taagaaaacg gtttttcgat ataatcgtct cccccatttt caatcgccat 3733621 cacctgatcc atttccccgc ttctggcaga aataaagatg atcgggcttg tggagtgctg 3733681 gcggatctgc cggcaccaat aatatccgtc atatgccggc aaattgatat caagcagcac 3733741 cacatcgggc ttttcccgca aaaagacatc aagaacagct gtaaaatccg cggcgaccac 3733801 tgtttgatat ccgtattttt caaggtaatt ctgcaatagt ccgcgaatgt cttcactgtc 3733861 ttccacaatc atgattttat tcaaactgaa ccactcccgt ttcttacact gctgccatca 3733921 tcataatcgt tttgggcgta tggacgcaac accgcacaaa aaaaccgcca tctcggcggt 3733981 ttctggtctc tttagccgac ctgctgctta gctgctttac cggctgatcc gaactctctc 3734041 attttgcttc gcactgtctc ttccacggct tcaatgccgg gtgtcaaata gccgcgcggt 3734101 tcgtacagat cgctgttttc ctgaaacatg cggcgtgttt cgtctgtcca cgctaccata 3734161 cattccgtat tgatattgat cttcgcgtgg ccgagcgtga tggctttttt gatctgatcc 3734221 tgcggaatcc cggatgcccc gtgaagaacg aggggaatat cagtcatgcg ggagatagcc 3734281 tccatttcct taaatccgag attcggctca ccctgatatt tgccgtgtac agagccgagg 3734341 gcggcggcca gcgcgtcgat attggtttct ttaacgatcc gctcacattc cgtgatatcc 3734401 gcatagcgga ccccgccgac cagtccgtct tccattccgc cgaccgtgcc gacttcggct 3734461 tctactgaca cgccgtgttt tgcggcataa tcggtgactt cttttgtcat cgcgatattc 3734521 tcgtcaatcg gctgatggga gccgtcaatc atcactgagc tgaatccggc atcaatggcc 3734581 tgtctgcagc gttccgcact gctgccgtga tcgagatgaa gcacgaccgg aacggtaatc 3734641 gccatgtcct ctattaacgc gccgaccatg gcggcaatcg ttttaaatcc gcctaaatag 3734701 tcgaccaggc gatcggaagc cgcggcgatg accggtgatt gctccttttg cgccgcctgc 3734761 aaaatcgcct tcgtccattg caggccgttg atattaaact ggccaattgc atattgctcc 3734821 cgctttgcat cttcaagaag ctctttcatc gatacaaaag ccatattcac ccctccttta 3734881 tccattacat gctgaagtat tttgatacga catccactgt tgtttttttc gctgtttgaa 3734941 tggcttcctc agcagtcagc ttatagtatt caggccggaa gagctcaacc gaaacaacat 3735001 cagagaagcc gatttccttc agtgctgata agtgggcatc taagtcaatt gccccttgtc 3735061 ccggccatac acgatcctca tctgttaaaa agccgattgg gaaatcttct gtatcatcaa 3735121 tatgatagat gaagattttc tttccgtccg cctgctttaa gctctcaata tttgaaccca 3735181 ttgcatggaa gtgaaaactg tcaaggacaa gcccgacatt gtcacggtta actgtgttta 3735241 caatctcata cgcctgttca aacgtattga ccgtacattg cggatggccg acaaactcaa 3735301 gcgcgatttt tacgccgtac ggctccgcga tatctgacag ctcagtcagc acgtctacac 3735361 tgctcttttt gatctcttct tttacaatct tctgctctgt cacaagcgga acggccacca 3735421 catatttcac accgagggtt ttgcatgttt ccatcatgcc tttaaattca gtgatgatct 3735481 cgttgtgacc cttttcatca cggttgttga agaaaacgag tgcgtttaag gcaagcggtt 3735541 tgatgtggtg ggtttgaaaa tattccgcaa ggtcatccaa tgaatgatct tttaagtact 3735601 ccggcagctt atccatagta cggatttcaa tataatcata gccatgcttt tcgcatagtt 3735661 ctaaatccag tttaaggttt gagttttcca atgttgtcgc ttcattaaaa caaagtttca 3735721 tgccagactc ccccatctgc gttttagata tgaagggagt tcggcaggaa ggctgtcgcc 3735781 atatcccgcc gaactccatg ctcagcttat gccagaccta attcttcttt cattttctta 3735841 agcataaatc ggcttgattc atccgctctt tcatcgaccc aagcaaatac ggcattcgtc 3735901 gcaattccgt cgaacttcat ctctctcagt tttctgaaaa tcgtatcaaa atcaacctcg 3735961 ccttggccaa tgtccaaatg ctggtgaacc gttactttcg cgtcaggcgg attgacgatg 3736021 tagcgaaggc catgagccgc tttatgatta taggtatctg caaataaaac atgtgtgagg 3736081 cggtcgccgg cttcgtcaaa catggtctcg atgtcgcctt tgccgtcatc atagaagaac 3736141 gtatgcgcag tcgagtagac aagattgatc caatccttgt caagcgcgcg gatcatatcc 3736201 atcgcacctt tgtgcgtttc gataaaatca tatggatggg cttgaagatt gagtttaatg 3736261 ccttcttttt caaagactgg cagaagctca tccatggatt tgataaattt ttcttcactt 3736321 gttaaaggat catattttga accgctgaat tcgctgttca tcaaatccac ttcaagttca 3736381 accgcaattt cgattgcccg tttccagttg cgcactgctg cctggcggcg gtcttcatcg 3736441 ggtcccgccc agtggtaaag aggaagaagc gatgaaagct taacacctgt atctcttaaa 3736501 aggcgcttta attgtttgat ctttgctgaa tcgactttcg gatatttata aaacgggcaa 3736561 aaatcctcgc gcggcgataa ttcgatatat tcatagccga gctctgccgt tttatagacc 3736621 atttcctcta aagttaaatc atcacgatac atggatggat ccaatgctaa cttcatattt 3736681 tcactcctct gttttttagt tttgaactgt tgtaaaagat tgatagaatt ccggtttttc 3736741 cttcaattca accttttctt tttgtccaga ttcctgggct tttacacacg cgtcagtcgt 3736801 gacagcagca atatagccgt cccatgccgt cggtccgctg acctcgcctt tcttttgaat 3736861 cgaatcaata aagtcttgga tttccacatc atacgcagcg acaaagcgtc tctgccaatc 3736921 catcaaaata tcagtgctga atctgccttc ttttctcaag ctgatgcttg atggctcggg 3736981 aagcttgatg atgccgtctt ctccgacgat ttcacattga atgtcatagc cgtatttaca 3737041 gttcacatag atttcagcat tgatgacgat accgcctttt gtttcaatca cgacgatttg 3737101 cggatctttt aaatgtggaa gcgcgttttt tgattttttc ggatagatga cttgaacgga 3737161 ctcgtagtca tcattgacga gccagtggag cacgtcaatt tcatgaacaa gcgtgtcgac 3737221 tacagccata tccgttgtat agttatctcc tacagtcggg ttgcggtgcg cgcagtgaat 3737281 cataagaggc tcgccgatga catgattatc gagcgcttct ttcagctgta cgtaaccgct 3737341 gtcataacgg cgcatgaagc cgacttgaac aaggcgtttg cccactttga tttcttcttc 3737401 gacaatgcgc atgcatcctt cagccgttgt cgcgagcggt ttttcacaga acacatattt 3737461 ctgggcttta atcgctttca gcacgcttga ctcatgcgca ggcccccagc ttgtcactaa 3737521 aacagcgtct acattttcgt ctgcaagcaa gctgtcatca ttcggataaa ccgtcgcgtt 3737581 taattggtat tgctcaacga ccttttgtgc agcttcttga ttaacatccg ttacagctac 3737641 aatttccgcg cctgacagct tgttcgtgat acggttaata tgttcttttc cgattgctcc 3737701 agttccaatt acgccaatac gtaaactcat tgacagccac tccttctgtt ggttacatga 3737761 ttttgctttc tgttcctttc tttacttggc tctgaggaga cccgtagagt tcctcttgaa 3737821 tttgttcaag cgacttgcca gacgtattcg gcgcaaagag cagcccgatg atcatactgg 3737881 ccgtcacaca tccgagaaga attgcagcca tcgttccaat gccgaaattg gtgataatca 3737941 ttgggacaaa cagactccaa atccctattg aaatacggac aaggaaaaac atcagtcctt 3738001 gtgcggaagc acgatattgc gtaggaaaga tttcgctggc ccataactga tagttcgctt 3738061 gctgcccggc tccgttattg atgccgatca cgacaataaa caggagcaga atcggcaggc 3738121 cttcaactgg cagcagaaac agtgtccacc cgatcaccgc catgaaagcg gcgattccaa 3738181 atacggtttt tctatatttg tcggcaaagg gcatgaagat caaggcgacc cccaatcctg 3738241 tgaagataaa cagccccatt tgcaaaaggt tggccatgtt ggcagataca ccgccgacct 3738301 gctgataaat gtatggcata aagaagccca tgaccccggc ggctaggttc caaaccaagt 3738361 acacacccat caaaaacagg atgcttttta gatacatagg cttgagcaaa tcaaaatacg 3738421 atgtcttatt caatacagcc ggcttctctg cctgagcttc ctccggctga ttttttgtct 3738481 gccaggcgtc tgattccgga agcctgattc tcaggatgta cgtaatcagc gcaatcacaa 3738541 gcagatgggc aaatacgatt ttattcccca agagtcccaa gtcaccggcc agtacggaga 3738601 ggagcagtac aacgacagcg cccgcggccc aagcgacttg tgctacgccg caatgcctgg 3738661 cccgattctt ctttggcgca ttttccgcaa taatggtcca tgacgcggtt atgtcagccc 3738721 ctactgataa accgataatg atgtaaccgc ttaacaacat ggggaaatta accccgaaca 3738781 aaaccaaaca aatccctagt gcataaacca gcatactatt ggtataaaca gccttccgtc 3738841 cgactttatc agccagaaac ccgccaagca gcgcgccgac agcggcagaa atcgcatttg 3738901 cgctcaacgc gccgagcagc ccgatttgcg tatcggatag cttaaggtaa ctgacccata 3738961 atgataaacc ggcggagcct gccacaattg aaccggcatc aatatagttg gccaatgctg 3739021 ccgcgattgt ccgtttattg aaggctgaat ctccattggt attgcccata tgttcattcc 3739081 ccattaagcc agatccaaca actgctgatc aatatagttt ctcgcaatca atgcatactc 3739141 cagcgggttt gcaacatcgg ggtcttgttc agcttcaatg acaatccatc cggaataact 3739201 gtgcttcaac agcagctgat atacttctct aaagtcaatg cagccgtcac cgggaaccgt 3739261 aaacatgcct tttaaaaatg attgccggaa cgattgtcct tcgagcctgc attgttccat 3739321 gacattcagg cgggcatcct taaagtgcac atgcttaatg cggccgatat gcttctcaag 3739381 catccccatg taatcgccgt cagaaatata cgcatggcct gtatcataga ggaggtgtac 3739441 atgcgcaggg tctgttcctg ccatcaggcg gtccacttct tccgctgttt ggacaccagt 3739501 gccgagatga tgatgataga caagcttcaa gccatgctga gcggcaattt cgccaaggtg 3739561 attcagccct tcgcaaagcc gctcccattc atcatccgta aagtgcggct tctctgtgaa 3739621 cacatttttc tccaagcttt gcacgctgta cgtttgttca gagacaactg cgacatccgc 3739681 gtttacttgc tgcaaatact cacaatgcag ggtaaatgtc tttgccgctt caccaagtcc 3739741 gtcacgcaaa ataaaactgc tgaaccattt tcctgcaatg cgtaagttcc gaagcttcag 3739801 ctctttgttc aggatggcag gttcggggaa aaagcccccg acctccgtgc cttgaaaacg 3739861 tgcgacaacg atatcactta acaaatgctg aagtgtattt cccgctccaa tttcaggcat 3739921 gtcatcattc cgccacccaa tgggagcgat tccccacagg atttcatttt tgcccatcta 3739981 tggtgcctcc cctctaatac tgcttcgcag attccagctt tttctctttt gcttcgtatg 3740041 ctttctgaac gctttcttgt tcagatacct ctgccacccc gacatgccac cagctgtcat 3740101 agccgtccgt cattgtttta ggcagcacct tcatttcaat taatgttgat acatcctgtt 3740161 tcttcgcatc ctctaacgca gcttttaatt cttctactgt gtttgcacgg taggttttcg 3740221 cgccgtatcc ctcagcgact ttcgcgtaat cgacattcag gatttggttg tcatctgtgc 3740281 ggaactcgca atagtagctg ccgctgccgt gatccatttg caggttgttg atgcatccga 3740341 atcctgagtt gtcaaagagc agcacattga ttttcttgtt gtactgaatc gccgtgatca 3740401 gttcagaatg aagcatcagg aagctgccgt ctccgacgat tgaatacact tctctgtcag 3740461 ggtgggccag tttaagaccg agtgtcccgg acacttcata gcccatgcaa gaatatccat 3740521 actccaggtg atacgtattc ggaacattag aatgccacag acgctgcaaa tctcctggga 3740581 gtgagcctgc tgaacagatg atgacgctgt cttcaggaat cgtctcgttg attgtcagca 3740641 atgccgttgt ttgcggaagc tccgtattca acgcgtcagc atattcattc aggacctctt 3740701 gagaaaagtg atttttgatt tccggatcaa atgcttcccg cttaaacgtc actttgctga 3740761 gacgctcgcg ttcagctagc cattcgtcct tcagctcccg gatcgttgtg ccgaactcgc 3740821 tctcatagcc ttcaagcaag ccgtgcagtt tgccaagcgt cactttcgca tccgccacca 3740881 cttggaatgc atcaagttta tacgcctgca ttcggctgac gttaatgttc aaaaacttcg 3740941 ctttatcaaa atcaaaagcg gtcttagagg atgtcgcaaa atctgtatac cttgtgccga 3741001 tgccgataat caaatcagct tggcgggccg ctttgtttgc cgcaagtgta cctgtgatgc 3741061 ccattccgcc aaggttgttc gcaaaatctg cctcaacggt agactttcct gcctgcgttt 3741121 caactaacgg aatgttatag gcttcagaaa tggcaaccaa ttcatcgcgc gcaccggaat 3741181 attttgcgcc tccgccgacg agaatcacag gttttttgct ggatttaatc agctccgccg 3741241 caccttgaag ctcgcgctcg ctcggctgca tgcgatcaat atagtgaacc cgtttgacga 3741301 agaaactttc atcaaaatcg tatgcttccc cttcaacatc ctgagaaata caaatcgttg 3741361 ccggacctgc ttttgccgga tcagtcatga cttcaaacgc gcgcagcaaa ctgctcatca 3741421 gctgctcagg gcgcgtaatg cggtcccagt atctcgatac aggcttcaat gcatcgtttg 3741481 tcgtaatcgc cgcactgtat tcttgctcca tttgctgcag tacagggtct ggctgtcttg 3741541 tcgcaaatgt gtctgccgga atcaagagaa ctgggatatt atttgccaat gcagtgccgg 3741601 ctgccgccac caagttagcc gctccaggtc cgacggatgt agacaccgca tatatttttc 3741661 ttctcagcat ttgcttgctg tacgccatgg ccgcatgcgc cattccttgt tcatttttcc 3741721 cttgatagac tttcaaatgg cctgcatcct gctcaagcgc ctgcccgatc cctaatacgt 3741781 ttccatgacc gaaaatcgtg aagatccctt cgacaaaagg ctcttccttt ccatctacat 3741841 ggatgtactg ctggtttaag aatttaatca gcgcctgcgc agttgttaag cgaattttct 3741901 tacccacaaa cgatcccacc tttactcgat ctttttcaat tatgactgtg cttcaataag 3741961 ctgttcgatt tcttccgcag tcggcatcgc ttctgacgaa ctgtgcttgc tcaccacaat 3742021 ggaggctgaa gcactgccgt atttcaatgc cgtttcaatg tcttttccgc tgacaaggcc 3742081 atagataaag gctgacgcat aggagtcacc ggccccaaag gttttcagca cttttgtctt 3742141 gtacgcttga gcgcggaata cctcgccgga tttgctgtat gcgtaagagc cttcgacgcc 3742201 gtgtttgatg acaacgaggt cggctgaatg gccaaataaa tgattgacgg attcttcatt 3742261 gcttccgcct gtgcggtttt ccatcacatc aaattcatcg cgtgtgccga tgacgatatc 3742321 agactgctcg gcaaccaaag aataataaac ggctgtttca tctgatgact gccacgtata 3742381 tggccggtaa tccagttcga ataccacctt aacctgatgc tttttcgcgt attgaacagc 3742441 ttttaacacc gcttcccgtg acgggctttt ggcgagcgct gtcccggaga caagcagcat 3742501 tttcgcattt gcgatatagt cctcacttac ctctgaaggc tcaagataaa gatccgccac 3742561 atcatcgcga tacattaaga tgctgcattc ttcagggctg aggatttctg taaatgcaag 3742621 gcctgctttg tgtccatctt gatcaacaat catctgtgta gtatccacgc cggtctttct 3742681 catataggac tctatgaatc ttccatgctg gtcatccgga attttgccga tgaagcccgc 3742741 ttttaagcca agcttcgcgc tgccgatcgc gatattcgca ggtgaaccgc cgacatattt 3742801 cgaaaatgtc atcgtttctt ccattgggcg gttgtattcg actgcgttca gatcaataca 3742861 tgcccggccg atggcaacaa tatcaaaagc cttctcttca ttgaatgtat acttcatcgt 3742921 aaacagccac tcctcacttg ttagcgttct aaaatccatt catgcgccgg gtcgttataa 3742981 aacttccatt ttcgcgtcgg ccctgccatg acatttaaat agtaggatgt gtatccgtcc 3743041 ggaacgccta ccgggtggta tcccgcagga acgatgacaa cgttttcatt tcccacagtc 3743101 attgtctcgt caatagaacg gtcatctgtg tatacgcgct gaaacacaaa gccctgtccc 3743161 gggtctaact catggtagta cgtttcttct aagaaagatt cttccggcaa gttgtcttgg 3743221 tcatgtttgt gaggcgggta gctggaccag ttgccgctgt ctgtatagac ttcaactact 3743281 aatagactgt tagctgaagg gtctgaatcc ggaagaatgt tatgaacagt acgtttgttt 3743341 gaaaattgcc cgcgatgctc aattccgttg tcttccgctt tgatcagctt tgtcggaagc 3743401 tgcttttccg atggagaata gcaaagcgcc actcttgcgt cgctgaccgc tgtgatctca 3743461 aatgcacggt catttgaaat atagacgctg tctgtcggtt ttcgttcaaa tacgctttcg 3743521 cgcgtgccga tattctcaaa agtcgactca tgatctgtca ctgtaatttt ccccgttacc 3743581 gccacaatac agatttcttg ttttttcaat tcttctgtat agcttgaacc tgatgcaaga 3743641 tctaacactt taaactctac ataagtgaga tcagagttgg atgtcgttac ttcgtgcacg 3743701 agtttgaccc cattagacac ttcatgcgac tgcggcttac gcaacaaata actcatagag 3743761 aagccctcct ctttctattg gcagaatgag tccgaacagc gcacatggac gccgttcggc 3743821 tgttcgtcgt ttagttgaaa tcaggtgccg gatatcttgc cgtcaccact tttttacgtg 3743881 tatagaagtc gacgctgtct tttccgttcg catgcagcgt tccaaagaat gaagatttcc 3743941 agcctgagaa tgggaagaac gccattggag ccggcacacc aaggttgatg cctagcattc 3744001 ccgcatcaat gttttcacgg aagtagcgga ttgcgtttga gttggatgtg aacaagcagg 3744061 cgccgttcgc aaactcagac ttattggcga tttcaatcgc ttctttcagg tttttcacac 3744121 ggatgacaga taagaccgga gcgaaaattt catctttcca gatcgtcatt tctgttgtga 3744181 cattgtcaaa gatcgtcggg ccgacaaagt agccgtcgtc agacacattt tcacgtccgt 3744241 cacatacgag tctggcacct tcttcaagac ctttttcgat atagctgagc gtgcgcttct 3744301 tgttgtcttc gcgaatcacc ggtcctaaga acacgccgtc atcaaggccg ttaccgattt 3744361 taatgtccgc cactttttcc tgcagcttcg ccataaattc atcggcgatt ccttcttcaa 3744421 ctgtcacaac cgcacaagcc atgcagcgtt caccggcaga accgaaggca gctccaacga 3744481 tgtttgtaac cgtgtcttca agattcgcat cgttcaagac aatcgtatgg tttttcgcgc 3744541 cagtcagaga ttgaacgcgt tttaagtttt cgcttccttt tttgtagacg tattcgccta 3744601 ctggcttgga gcctacaaat gaaatcgctt taatttcggg atgctcgagg atgccgttca 3744661 caacgtcatg cgcaccgtat acgacgttga acaccccttt cggaaggccc gctttttcaa 3744721 aaagctcaac caatttctct gttaacagcg gagtccgctc agatggcttt aaaataaatg 3744781 tgttgccgag cgcgatcgcc atcgggaaca tccagcaagg aaccatcatc gggaagttga 3744841 atggcgcgat tccgccgaca actccgattg ggtaacggta gttcgccgct tcaacgtccg 3744901 ttgcgatgga agcaagtgag tcacccatca tcagggaagg tgctccagcg gcgaactcta 3744961 cgttttcaat cccgcgtccc acttcaccta aagcttcttt cgtgtttttt ccgttttcaa 3745021 tggtaattag atgagcaagt tcttctttat gctgagacag cagctgctgg aagttaaata 3745081 gaattctggc gcggcgagga accgccacct ttgaccatgt tttaaatgct tcagccgctg 3745141 tttgcgctgc gtaatcaata tcctcttttg tagaaatcgg cacttggcat agcacttctt 3745201 tcgtcgccgg attgacgaca tcttcatatt gatctgtttt gctttcaacc cattcaccgt 3745261 tgatgtagtt ttttaatttt ctgatttctg ccattcttat tgcctccttc attagtaaac 3745321 acatacactt gtatggatgg ttccggatag attcatatca atatccactt ttcagcaagc 3745381 caagaattaa acgctttcaa aaacaccaaa aaaataaatg gcggatgcat atttacatac 3745441 aagcaaccat ttcatgcaca acaggttact ttttggtcat ttcttggtta tattctaatc 3745501 gcataatacc cataagtcaa tcataaacac tacatttttt cattattttt attatattaa 3745561 tcttttaatc aagtaagaga agtaagagaa ggccgtccaa tcttgcaaaa gatatacacc 3745621 gatgttatca tttttaagca actattgatt aacttttggt ttttattata tatttatgtt 3745681 acgtaaagat tcaagaagga gttttttata tgaaactgat gcggattcag gaaatggagg 3745741 agtacatttt atcgcatggc actgtttcct tagatgagct gtgccaggtg ttcaatgtct 3745801 ccaaaaacac agtcagacgt gatatcaaca agctaacaga aaagggtgcg attgaaaaag 3745861 tatacggcgg cgtaacatct attgaaaaaa ccgcattagt tccttttgaa aatcgcacca 3745921 ttcagcacca ggatgaaaaa acaaaaatcg cccattatgc ttcccgattt attgaagatc 3745981 acgatttggt cttcattgat tcaggaacga cgacaaagtc tattcttgat acgcttgatc 3746041 cagccaaaaa tgtcaccatc ttaaccaaca gtttagacat tatcaatgcg gcgtcagctt 3746101 tgaagaatat caacttaatc attatcggaa acaactataa gagaaaaacc cgctcctttg 3746161 tcggcatgga cgacccggct atgcttgata agtacaatat caacaaagcc tttatgtccg 3746221 ctaccggaac gacgctgact cacggattga ccaattcgga tctgctggag tatgaaatta 3746281 aaaagaggat ttcagaaaaa gcaaaagaag tgtatctatt ggctgaccat tctaaattcg 3746341 gaaaatcaac gcttctgacg tatgcaccgt ttgacaggct gcattgcatt gtgacctctc 3746401 agccattaga cgacgagtac acgcagtact gcaatgagca tcaaatcggc attcatctgg 3746461 cctaacgttt acaatagtgt tgagagtcta tcatccattt tattctagga ggcagatcat 3746521 gaaaaaagcg aagctcggaa aatcagactt gcaggtattc cctatcggat taggaacaaa 3746581 tgctgtcgga ggacataacc tctacccgaa cctaaatgaa gaaaccggaa aagaattggt 3746641 gcgcgaggcg atccgtaatg gcgtgacaat gttagacacc gcttacattt acgggatcgg 3746701 ccgttccgaa gaattaattg gtgaagtgct gcgtgaattc aaccgtgaag atgttgtcat 3746761 cgcgacaaaa gccgctcaca gaaaacaagg caatgacttt gtctttgata attcaccaga 3746821 ttttcttaaa aaatcagttg atgaaagcct gaagcgcttg aataccgatt atattgattt 3746881 gttctacatt cacttccctg acgaacatac gcctaaggat gaagccgtta acgcgctgaa 3746941 tgagatgaag aaagccggaa aaatccgttc catcggtgta tccaacttct ctttagagca 3747001 attgaaagaa gcaaacaaag acggtttggt agatgtattg caaggcgaat acaacctgtt 3747061 aaaccgtgaa gcggaaaaaa cattcttccc gtatacgaag gagcataata tttcatttat 3747121 cccttacttc cctctcgtat caggtttatt ggcaggaaag tatacagaag atacaacgtt 3747181 cccagaaggc gacctgcgaa acgaacagga acacttcaag ggtgagcgtt tcaaagaaaa 3747241 tatcagaaag gtcaacaagc ttgcgccgat tgccgaaaaa cacaacgtgg atatccctca 3747301 catcgtattg gcctggtatt tagcaagacc ggaaattgat attttaatcc caggagcaaa 3747361 acgtgccgat cagctgattg ataacatcaa aacagctgac gtgacgcttt ctcaagagga 3747421 tatttcattt attgataagc tgttcgcata agaagaaaac agccttctcc aatggagaag 3747481 gctgtttttt tgtgcgataa attcctaaat aactgatttt gaagcaaaac cttacaaaat 3747541 gagccataaa tccgataaaa taaaggtagt ttatctcaga aagaaagtga ttgagaaagc 3747601 aaaagtatga aacgttcata tcatctagct catatgaaat aaagctgacc cagcttcttt 3747661 tatttgctgg tcagaatagc ggaccgtttc gatggtctat ggaggaaaca gaatgaaact 3747721 taaatatgta aaagccttag ttgcagtaac cgttgcttta ggtgtactgc tgccatcaac 3747781 gatttctcat gcaaagagct ttagcggccg ctcatcatct agttacagca gccgaagttc 3747841 aagctcatca tacagcggaa gctataaatc aagcccgaaa tcaagctaca gctcaggatc 3747901 aagctcttct agcaaaaaat ccaagacgtc tgacgattca tcatcatcga tttcgcttaa 3747961 aaagaagcct tcggaaaagg caagttcatc aagctctaaa aaatcgtcag gcaccttttc 3748021 cggcgctaca tcaaaagtaa ccggaaagac atacagcgga aaaacgtcta aagcctatgt 3748081 tggcggacgt tatgtttcag tcaatcatta ctatcacgca ggtttcgcgc catcaggatg 3748141 gtttggatat tatagcggat ttacaatggg tatgttcatg atcagcatga tgcacccatg 3748201 gggttacacc tatcatccag tcggaggccc cggttatgtt tcttatggcg cttcacccat 3748261 tgcctggatc gttgatatca tcgctttgat tattatttta atcattgtca tcgcattgat 3748321 tcgcgcattt aaagcaccga agacgtacag aaggagattt taggcaatga gattaatatt 3748381 aaatgagcaa gaaattgtag acggaatttg cgtgtatatt tccaatgaag aagatatcta 3748441 ccctgaagac gttgaagtaa aagaactatc gtacaacaag cgtacagggt tcttcgctga 3748501 agctacattt ggcctgcacc acaagcagct tatgtcagat gacatttcag aaggcattat 3748561 tcagttctta gaggaatacc acaacttcaa tccggacgtt accgtcgttg aattgcaatt 3748621 tgataagaaa aaaggcttct ccgccttggt ttttgtcaac gaagcagaag aataaaaatg 3748681 tcttaatcaa accttactcc gcgcgggtaa ggttttttta atggtttctc tgagcataaa 3748741 gttatttcgt ttttcctaaa ctcagcggat ctgtgatcat ctcttttggc tataaagttt 3748801 ccgttttttc aaaacaaatg tttcaaatga gataggaaat gggtactaat ctattaactt 3748861 tgttacatat ttttagatac tcattggctc aacaactgag gaggagacat ttgtgaagaa 3748921 agacacaagg aaatatatga tctacttttt cggcgcttta gggggactgc tatatggtta 3748981 cgatacaggt gttatctccg gagcactcct gtttatcaat aacgatattc ctttaacgac 3749041 attgacagaa ggattggttg tcagcatgct gctccttggc gcgattttcg gttctgcctt 3749101 gagcggcaca tgctcagacc gctggggcag gagaaaggtt gtatttgtcc tttccatcat 3749161 ttttattatc ggtgcgctcg cttgcgcatt ttctcaaaca atcggcatgc tgattgcatc 3749221 tagggtgata ctcgggttgg ccgtcggcgg ttcaacggca cttgtgcccg tgtatctttc 3749281 cgaaatggca ccgacgaaaa ttcgcgggac actcggcaca atgaacaact taatgattgt 3749341 caccgggatt ttgctcgcct atatcgttaa ctacctgttc acaccgtttg aagcgtggcg 3749401 ctggatggtc ggtctggctg cagtgcctgc cgtgcttcta ttaatcggca tcgccttcat 3749461 gccggaatcg ccaagatggc tcgtgaagcg cggcagcgaa gaagaagcga gacgcatcat 3749521 gaacatcact catgacccca aagacatcga aatggaattg gcagagatga agcaagggga 3749581 agcggagaaa aaagaaacga cacttggcgt gctgaaagcc aagtggattc gccctatgct 3749641 tctgattggc gtcggccttg ccattttcca gcaggcagtc ggcattaaca cggtcatcta 3749701 ctacgcgcca accattttta cgaaggccgg tcttggcaca tcagcttcgg cgctcggcac 3749761 aatgggaatc ggcatcctca acgtcatcat gtgtatcact gccatgatct taattgaccg 3749821 tgtcggccgc aaaaaacttc tgatctgggg aagtgtcggc atcacactga gccttgctgc 3749881 tttatcaggc gtgctcctga cactggggct ttccgcatca acagcgtgga tgacagtagt 3749941 ctttctcggt gtctatatcg tcttttacca ggcgacatgg ggtccggtag tgtgggtgct 3750001 catgcctgag ctcttcccgt ccaaagcacg cggagccgcg acagggttca cgactttggt 3750061 gttatcggcg gctaacctga tcgtgtcgct tgtcttcccg ctgatgctaa gcgcgatggg 3750121 catcgcatgg gtctttatgg ttttctcagt catttgtctt ctctcatttt tcttcgcgtt 3750181 ctacatggta ccggaaacca aagggaaaag cttggaggaa attgaagcaa gcctgaaaaa 3750241 acggtttaaa aagaagaaaa gcacccaaaa ccaagtgctg aatgagcgta cattataaaa 3750301 aaaggaatcg tctccttatg agacgattcc tttttctgtt tacaccatga ccttgcaaat 3750361 attgttcgta aattccacag ggtcctgaat cggcaggcct tcgatgagga gcgcctgatt 3750421 gtacagaagg tttgtgtaca ggctcagctt ctctttatct tgttcaaacg cgtcctgcag 3750481 tgtttggaat acctcgtgat ttgggttgat ttccagcact ttttccgcct tcacattttg 3750541 gctgtcaggc atcgcattta agattttttc catctcaatt gtcacttcgc cgtcagcagc 3750601 aaggcagact ggatgtgatt taagccgttt tgagattctg acgtttttca ctttgtctga 3750661 cagaatgttt ttcatttcct caaacagatc cttatacttg ctttcctctt cctcggactg 3750721 cttttgatcc tcatccgtgt ctatgccaag gtctccgctt gatacggact tgaattcttt 3750781 ttcctgataa gaagccagca ttttaattgc aaactcatcg atgtcctcag taaagtagag 3750841 gatttcatag cctttgtccg ccaccatttc cgtttgcggc agtttctcaa tgcggtcgta 3750901 agaatcaccg gtcgcgtaat aaatgaattt ctgctcctct ggcattctgg aaacatactc 3750961 gtctaagctg accagttttt tctcttttga agagtagaat aagaggagat ccttcaattg 3751021 atccttattc gcgccaaaat cattgtacac gccgaatttc agctgtctgc cgaacgactt 3751081 gtagaacgtc tcgtatttct cgcggtcttt tttcaacagg ctttgcagct cgcttttgat 3751141 tttcttgctg atgtttttcg cgatcagctt cagctggcgg tcatgctgca gcatttctct 3751201 ggaaatattc agcgacagat cctcagaatc gaccatgccc ttcacaaagc tgaagtggtc 3751261 cggtagcagg tctgcgcact tattcatgat cagcacgcca ttggaataca gctccaagcc 3751321 tttctcatat tccttggaat agtagtcaaa cggcatgttt tcagggacga atagaatcgc 3751381 gttgtagcga accgctccat ccacgctgat atgaacgtgt gtcagcggtt tatcaaaccc 3751441 gtaatgcttt tcagcataga atttttcata atcctcatct gtcagctcgc ttttgttttt 3751501 tctccagatc ggcaccatgc tgttgaccgt ctgctcttcc tgcacctctt caaattcatt 3751561 ttcgctgcct tccttcggct tattaatggt tgtatccatt ttgatcgggt agcgaatgaa 3751621 gtcggagtac ttcttgatga tcgcttttaa acgatattcc tctaaaaact cgtcatagct 3751681 gtcatcttct gtgttctctt tgattttcag gataatgtct gtaccgacag aatccttttc 3751741 acacggctca atcgtatagc cgtctgcacc cgcagactcc catttataag cctcttcgct 3751801 gccaagcgct ttactgatga ctgtcacgac atcggcaacc ataaatgccg cgtaaaaacc 3751861 gacaccgaac tgcccgataa tgtcatgtcc gtctttcagc tcgttttcct ttttaaacgc 3751921 gagggaaccg ctttttgcaa ttgttccaag atgctgttca agctcatcct ttgtcattcc 3751981 gatccccgta tcagagatgg ttaatgttct cgcatctttg tcagctgcga cctttatgta 3752041 gtaactgtct ttatcaaacg taagcgcatc gtccgtaagc gctttgtaat agattttgtc 3752101 aatcgcatca ctcgaattgg agattaactc gcgcaggaaa atttcttttt gggtataaat 3752161 ggagttaatc atcatatcca gcaagcgttt agactctgct ttaaactctt ttttcgccac 3752221 tcttgatcgc tcctttacca ttatgtaaac ccttttcagc atctatttat cacataagat 3752281 gacaattgtc aattagattg atagatgcat atatatgtaa atttaacatt agttggattt 3752341 gttttcactc tttttctcac tcattctcat aaaaaagaga ggcttcatca tcctctcttt 3752401 ttttctgtgt cattccaacg gccaaactcc cgcttcatcc atatatgcac cgggtagaaa 3752461 aacaaaccga acggtatcaa aaacaaaaga ttatgccatg aagcattcag aaatgcgctt 3752521 gcagtcaccg ggaacgtaat ctcttgcaat aaaaaagaga tgacagtcag cacaacaaat 3752581 gcagatggaa tggtcacgat gcaataaaac ttgagctcct tcttatgctg taccttcaaa 3752641 catacaaacc tcccaacaat ttctaattca tcttaacata tgctggcctt tcttttctcg 3752701 catgtttatc actgcacata gcgggaagac aaatagaaaa aggaggtctc gtatcatggg 3752761 aagacttgaa aacaaaacag cagttatcac aggcgccgcg acaggcattg gtcaagcgac 3752821 ggcggaggtt tttgccaatg aaggcgcgcg tgtgatcatc ggagatatca ataaagatca 3752881 aatggaagaa acagttgacg caatcagaaa aaacggagga caggccgaat cctttcacct 3752941 cgatgtgtca gatgaaaaca gtgtgaaagc atttgctgat caaatcaagg atgcatgcgg 3753001 aacgattgat attctgttta ataatgccgg cgttgatcag gaaggcggaa aggtgcacga 3753061 atatccggtt gacctgtttg accgcattat cgccgtcgac ctgcgcggca cattcctttg 3753121 cagcaaatat ttgattccgc tcatgctcga aaatggaggc tccatcatca acacctcctc 3753181 catgtcaggc cgtgccgcgg accttgaccg ctccggctac aacgccgcaa aaggcggtat 3753241 caccaacctg acaaaggcaa tggcaatcga ctacgcacga aacggcatcc gcgtcaattc 3753301 catttcaccg ggcacgatcg aaacaccgct gattgacaaa ttagcaggca caaaagaaca 3753361 ggaaatgggc gaacaattcc gcgaagccaa caaatggatc acgccgctcg gacgtcttgg 3753421 ccagcccaaa gaaatggcaa cagtggcact gttcctcgca tcagacgaca gctcatacgt 3753481 cacaggagaa gacatcaccg cagacggcgg catcatggcg tacacatggc ctgggaagat 3753541 gctgattgag gagaaatgga aggaagaaac gaaataagag agggagcccc ctctcttttt 3753601 gtcttttaaa gcaatacaac cttatatttc ttcacatcca aaaactgcaa aaactccctc 3753661 gccagcactt caggcggatg cgcctttcct tcatccagcc gatacaaaag caacccgata 3753721 atcattgcgg atacataatg ggcataaagc tttttctctg cgtgaatatc agtttgctga 3753781 tgcagataaa acgattccag cgctttgaac atatcaggta tcacatgagg aacaccccat 3753841 tcccgattga gaaaatggac aatgggcatg tttgacaaag cagaaagcag aatggcgagc 3753901 gccttctccg cttcctttaa ggaaaattca ttcgggctgg aggcaatcgt caggtgatca 3753961 atgatctccg cacatgatcg ctgtatcatg gtttggagca attcctcctt attggcatag 3754021 tgatcataaa aggttgcacg gcggatattg cttttacgcg taatatctga aatcgtgatg 3754081 cccgcgtagt cttgtttctc cgccaataca tccagaaatg ccttctgcag cgcctctctc 3754141 gttcgaacca cccgcctgtc gatttgcttc tccttctctc gctctcctgg cacagctttt 3754201 ccaaacagcc aataaaaccg cttttgagaa acaagctccc ataccttctg gctgatggct 3754261 tcaggagacg cggccgcatc ctcattcagc caatacagga taatcgcgta cgtgtacaag 3754321 gcccgataat gtccataaat gtcccgttca atcggcgtta aattcacatg gatcggagcc 3754381 agcagcacat cctgctgaaa cacatcctta aaaaaacgat gaaaatgtcc tctgttcatc 3754441 atcacagaaa aaaaggaacg atgctcatga acaaaggaca gcgtcggatg caccgtttgc 3754501 cgttttttgt tcaaatgaag ggtatccata tgactgaagg cgtcaaaaag cgctttgccc 3754561 agtccttcct tcatgtcttc gatcacatcc tcaatgattg aaaacttatc ctcataataa 3754621 aggtagagcg atccgcggct cactttggcc ttctcagcga tttctttcat tgtgatgtgt 3754681 tgaatatctc tatctttcaa taaagccagc agcgcctctt tcacttgagc ttcggcagat 3754741 tccggcacaa aagacacctc caatcattag acagatctta gatatatgta cggtaacgta 3754801 tagatggttc accgttgtct ttcttacaga aaaggtacca ccttataata ggtccgagaa 3754861 aagaagaaag caaatgaggg ggattttaca atggaacagc aagtaaagga cgacatccag 3754921 cgtgtctttc agcttcagaa aaaacagcaa aaagccttgc gcgcttcaac agcggaacag 3754981 cggagagaaa agcttcaacg ctttttagat tccgtcatcg cccatgaaga agaaatcatc 3755041 gaagcgatcc gcaaagacgt ccgcaaacca tatcacgaag tcaaaaaagc ggaaatcgaa 3755101 ggaacaaaaa aagcgattag agataatatg aataacctgg aacaatggat ggcgcctaaa 3755161 gaagtcggtt catcgttaag ccctgacgca aacggaattc ttatgtacga gcctaaaggc 3755221 gtcacactca tcctcggccc gtggaactat ccgtttatgc tgacgatggc gccgcttgcc 3755281 gcttctctcg cagccggaaa cagcgcgatt gtgaagctgt ccgatttcac gatgaacacg 3755341 agcaacattg ctgctaaagt aataagagac gcttttgatg aaaaagaagt cgcgattttt 3755401 gaaggagagg ttgaggtggc aaccgaacta cttgatcagc cgttcgacca tattttcttc 3755461 actggaagca caaatgtcgg gaaaattgtc atgacagcgg ctgccaaaca cttggcatct 3755521 gtcacacttg agcttggcgg caagagcccg acgatcattg acagtgaata cgatctgatg 3755581 gacgcagcga aaaagatcgc cgtcgggaaa ttcgtaaacg ccggccaaac ctgcatcgca 3755641 cctgattacc tgttcattaa aaaagacgtt caggacaggt tcgcggggat tttacaaaca 3755701 gtcgtcaacg ctggatttat ggaggatgat cataccccag accgcagcaa atttacgcag 3755761 atcgtcaatg accgcaactt caaccgcgtc aaagatctgt tcgacgatgc catcgaaaga 3755821 ggggcggaag tggtgttcgg cggcgtattc gatgccagcg accgcacgat ctcgccaacc 3755881 gttttgaaaa acgtcacgcc tgacatgaaa atcatgcagg aggaaatctt cgcatcgatc 3755941 ctgccaatga tgaactatga agacatcgac gaggtcatcg attacgtaaa tgaccgcgat 3756001 aaaccgcttg cactttatgt gttcagcaaa aaccaagatc tgattgacaa cgtccttcag 3756061 cacacgacat caggaaatgc cgccatcaat gatgtcgtcg tccatttcag tgacgtcaac 3756121 ctgccattcg gcggcgtcaa cacaagcgga atcggctcct atcatggggt atacggattc 3756181 aaagagtttt ctcatgagaa gggtgtattt attcaggccg ctgaataatc gcatgatcaa 3756241 aaggcgcttc cttagaggag cgccttttat tgtaactcct tgaccaaaag caattcatca 3756301 cggataggta ttttattatc tgccagtaaa ggaatttcgg gcttcatctt tctggccgtc 3756361 tcgactgcat tcacaaatag tcgatccaac cggtaccctc tcttctgata aaacgctaat 3756421 gcatgaatat tatcattggt tgtgatcagt tttatttgtt tgatatttct ctctctgcat 3756481 gcttcctcgg ctttctctag cagagctgtt ccgatccctt tattctcaat gacactatcc 3756541 agcgaaatga tttcacaggc atcttcttca aatatgtatg taataaggcc aacaatctgg 3756601 ttatcatcgt tgagcattcc ataaccatct aattcatcgc agttataaat accgctagaa 3756661 ataaccattt gcggactgcc ccagtgtttt tgaaaaaacg cggaaacaag atctttaggt 3756721 acctggcatg tcggaataat attcatattt tcctcctttt agctgaacaa aaataagaga 3756781 attaacaacc tattttatgt cattaatccc cttatctagt atttactaga acttataact 3756841 tgtcaaaagc tgtctgaata ccaattgcgt ggattgataa ggatcaaaat ctgaatcctg 3756901 agattggaag atttgctctg gggtcaatgt ctctgcgttc tctgataacg tttgaatcag 3756961 actttccaaa tatccattta actctgattt ggacgattca tgtagggatt gatgatttac 3757021 agcgagttct ctaaatctgt tatcactgat taattttttt cgaagagctg ctagcatcaa 3757081 gtcaagccat gcaggctggc caaatgtaat atttaaagct aacgttgctt gatcagattt 3757141 ggtggagtgc cataaacctc ttggcaaata cagcatggtt cccggtgtta aattaacgat 3757201 ttctgcatct ggcagatcct cttttggcgg atctcctttc caatatgact gtaaatcatc 3757261 aggatagtaa ggagcctctg ataaatcata gtgctgcatt ggattgctca cattttcatt 3757321 cttggcaagc ttccatgttt tctcaccttg aatttgaaaa atcaagttgg tgtaggcgtc 3757381 aaaatgggct ttgaatcccc cgccattttt cgccgcgtaa acaatggctt tggaagaagt 3757441 acccgcaggc agtcttaatt ccgctttgag tttttctatc caccttctga cttggggaat 3757501 aaataggtcg gtgaaatcaa actctaatgc agcccctttt tcataccact ctaaagcctc 3757561 tgcaggtgac acaagaaatc tgtctgtgat cccttcagat tcttcaatca cagcatcacc 3757621 aacgaccatg actggattat tgtagatagc caatacgttt tctagcgttc taaccttttc 3757681 aaaccccggt atgcttgtaa atctctccac ttctcctctg gctaccaaag gttttacagg 3757741 ccaatattct tctaaaaact cactcatcgt tacaggactg atgatagact ccaaaaccga 3757801 ttcggttaca gcactcatat tatccctccc aaaaaaagta acttcaccac aaagatataa 3757861 catttttttc taaaagtaaa tattgacaga attatcagag gattataata tttagttgtg 3757921 cgtgatagcc tattttttta caaggaagga gggaaaagga tgaaaaaggc ttataagaaa 3757981 cctcgtcttt ttgaactgcg ccgtgctgta gcagctggcg gccattaatc tcatatagca 3758041 tttgacatct agtactctat tttaggaggg atgctcaatg aaaaaagctt ataagaaacc 3758101 tcgccttttt gaactgcgcc gtgctgtagc agctggcggc cattaatctc atatagcatt 3758161 tgacatctag tactctattt taggagggat gctcaatgaa aaaagcttat aagaaacctc 3758221 gcctttttga attgcgccgc gctgtagcag ctggcggtca ttaatcttat ccaaaacgat 3758281 taacgtttga ggctatcacg ccaacttgat aaggaggatg ctgaagatga ttacggctga 3758341 agaatgcaga acgtacaaag aatttgttga tctttaccaa tcctatcttt accccttgct 3758401 tggcgccaga ctgtcccgga tgtattcccc caaaaacaaa gtcattatcg atatgggcac 3758461 aggtccaggt tatttaagca ttcagttggc taaaagaaca aatgcgcacg tgcatgctgt 3758521 cgatattaac ccggccatgc atgaaatcgc tcaagaagaa gctaaaaaaa gcggagtaag 3758581 cagcctgatt tcatttgatt tggaagatgt ccaccattta tcttacgctg accaatatgc 3758641 tgacttcatc gtctcctact cttgcctgca tcattgggaa gacgttgtta aaggacttaa 3758701 agagtgctat agagttctgg ctccgggcgg aaaaattgtc attttggata catttaatcc 3758761 ccaaggaagc catttagaga ttatgcgaaa acaaatcaaa gaaccggaat acttcaggtt 3758821 tgtaagagag gcatttgaag aaagttattc ctttgaagac attcaccagt ttgttcagga 3758881 tgccggcatt cccaattatt cattagaaac ctttcacttt ttaccggagg attttataga 3758941 aagcttagat gagctggagg atgctcccct gtgggaacaa aatgatcaaa gtactgatca 3759001 tgaaattgag tctgtcacat ggatgttaac gatagaaaaa gaaaaggaag gtgcattgta 3759061 atgatcaatg aatcaactgt tttatccaaa aatccagaaa tgccatcaag aaaatatttg 3759121 aaaagcatta ttatagagcc gggcatcact ttaaatgaaa tggcatcaga tatttataac 3759181 catatcgacg gcaaggtcag catacatgat atttgctcaa aaatcgtcaa tgaatatgat 3759241 gttgattatc aaacctgctt agaagattgt atggagctgt ttgagttgct tattgatcat 3759301 gaagcaatca aagttaagca gggggcatga gaattggaaa aacaaaaagt gcttgcttta 3759361 ccagacgatg tacatgagct gagtacacac cgttctaaat caatcgtaaa ttacatcatc 3759421 actctgcttg cctttgccaa aaaacaagga ttgactcatc aagatattgt aagctggatt 3759481 cacgagcaat atgaggaaag aggatattat gatgagtgga gacacattaa cagccaacaa 3759541 ccagttggat catttgtgga actctttata aaaggaagac gtttacttta tgacaaaatt 3759601 gaattgtttg aaacagaaga taaatatgtc gtaaataccc acacttggta tgaaaaagaa 3759661 cctagtgagg ccttttttta ttttgaaatt gatcccgaag aattttctgc gtacgcttcc 3759721 attctcgcaa tcgaaaacgc aaaacgtctc ggaattaaaa tcgatattgt aaaagaaaca 3759781 gatgtagaga cagcttatat ctataaacat caataacgct attgggaggg agacatatgt 3759841 gcgggctcgc gggtattata aatctggctg ctccccgttc tcaggaatgt acctttcata 3759901 tattgaaagg catggcagat gccatcagct ataggggacc ggatgatgaa caatatcata 3759961 ttgattccaa agtcggcttt gcatttcggc gattgtccat tcttgacctt gtaaatggac 3760021 agcagccctt tttaaatgag gatggatcaa tcgtcgttat ggtaaatgga gaaatttata 3760081 actataaaga actgaaggct tctttacaca atcatatgtt taaaacgaca tctgattgtg 3760141 aagtaattgt tcatttatat gaagaaaaag ggattggatt tgtagacgac atcatcggaa 3760201 tgttttcaat agccatttgg gacaaaaata aaaacaaagt atttttagtt cgtgaccgct 3760261 ttgggattaa accgcttttt tacacagagc taaaacacga gcttatattt gcctctgaaa 3760321 taaaatccct attttctcat cctcactgtc cccgccaatt taattggaaa gaagcactct 3760381 cagacatttg gctaagcggg gaagcagcca gtaatcataa agaaaccact tccttttttg 3760441 taaacatcca aaatctcgat gctggccatt atctcgaaat taatttgaca acaaatgaac 3760501 gaaaaacagc aagctattgg tctttacagg atattttgct caggcaaggc tatcgtgaga 3760561 atctccatcc cgatgacctg attgaaggat atagagaact gctggcagat tcagtccata 3760621 gatgtttaca aagcgacgtt gaagtcgggt tgtttcttag cggtggcatt gattcagctg 3760681 cagtcgcaca ttttgctgca gaaaaacagg atctccatac gtttacagta ttaagccaaa 3760741 gtacatttac aaatgaagat gcaaaatatg cccattggct ggctaaagat ttacaccttc 3760801 caaatcatca ggttctctat caattaggga acgatgagtt attacaacca gagtcatata 3760861 aacatttgtt atggatctgt gaaacaccgt tttgcggacc ggaacaatta tataagtttc 3760921 atttacataa gtatgccaaa gcgataaggc caaacctgaa agtcatgctg accggccagg 3760981 gcagcgacga atttaacggc ggttacagca cgacactttc accagccgag aacccaagtt 3761041 gggaaggatt tattgaatcg gtcaatacga tggagatgaa ccggctgcat cggctgcagg 3761101 gaaatatctt tagagtgtgg gaggagcatt ttggactttc tcctataaac ctttcttatt 3761161 taaagagcaa tgattccagc caagcagatc cttggcaatc gtatgtcctg acaaaatacc 3761221 gtgatctgca aatgtataat tgctggcatg aagatcggat cgccgcggct aatcatatcg 3761281 aaaaccgtgt accgttcttg gaccatcggc ttgttgaatg ggtttgcgga atacctgatg 3761341 gactccgtaa agacttgtta tgggataagt cggtattgcg aaaatcatta acaaatgagc 3761401 tgcatacaag ctatacccac cggccaaagg ttcctttttt ctatggtaag gacgtgagat 3761461 atacacataa aatgatgttt catcttctga agaaaaacaa ttatcagctt atagaggagg 3761521 ccttctctca cagcgatgcc tccagcataa tacaggttga acacattcat gccatcatga 3761581 catatttgga ggatgatcct gagtttacaa attttgaatt tttattaaga ctggtgaaca 3761641 tgggactttt atcaaaaatg actaaagaaa ccccttctgt tcaattagac ataaccagcc 3761701 atttagaatc gataacaata aaagactggc actcacagga aggtgatatt gccagtcgtt 3761761 taaatatctc agccaataag tgtgaaggac aagatatttt ggcgctaaac cctggcgtca 3761821 ctctgttaag gccggaaagc gatagtgagc attgcatcta cattgcggaa gaaggattta 3761881 ttcagtttat tgtttcggag gaagacgtcg gagcttggct gcatattctc tgcgatatta 3761941 atggaaaaga cacacttcat acgattttag acagacatgg tgtcagcctt gaagaagtgg 3762001 ccaaatatat tcaagaagcc atcgaacaca atatcatttt gatcaaacaa aaaaatctgc 3762061 cagaaggagc atatagatga gcatctttta ttcgttttcc gcacttaggg gattagcaat 3762121 ggggattttt tcgcctattt ggattcttta tctgatatct aaagattatg atttccttca 3762181 gattggatta atgggagcgg tacttgaaat tgctaagctt atatttgaag ttccttccgg 3762241 cgtttttgct gatcgttatg gaattaaaat ttcaattgcc agttcattct ttttctccat 3762301 ccttacatgg gccttcttcc cttttatcga ttcagctgct atttgcatac tggctatgat 3762361 catatgggct ttatcagatt ccttaatttc cggttctttt gaaacttgga tgagccgtgt 3762421 cgcaggggaa gatcgattcg gcaaagaaat gatgaaaaac acacaattgc taatcacttt 3762481 tttaattatt ggaagtattg ccagcgggta tttgtattca ttaaatatct attttccttt 3762541 cctgctcgtt atggtgatct acttattact atttatttgg atgtctgtat ttattaaagt 3762601 cccttctgtt tccgaaacaa atcatgggga tcagaaccaa catgattcga taaagattat 3762661 caaagaaagt ttaaaaatta tctttaacaa aaaaagggtt cttttaatcg tcatagccgg 3762721 tttctttaca gccacagcct atgacacaat ttcccgttac tggcagcctt ttttgagtga 3762781 tttaggcttt tcagaaaagt cactgggata tatttttgcc ctaggagggt ttaccgctct 3762841 cgttcttttg acattaacca tcaggttcga aaagaagatc gaaaaaaatc catatctcgc 3762901 tttaacctca ttggattcca tgggcatggt catgactttt ctattgtcta gagcattcag 3762961 gccgctgggc attccatgta cagcgttttt gcttgcaatt gaagatattc atcatccgat 3763021 cgtaacaagt tacttaaata agtttttccc cgattcatac aagaacacac ttttctcgtt 3763081 aaactcaggg gtaggagcaa ttggagaaat tctttccggt gtcattttcg gcatcatttc 3763141 cgcagccttt gggctctctg ccatgtttgt tgttgtagct gtatttctat taatccctat 3763201 tatcctttat acgatagtgc ctaagattaa agacaatgat atgaaagttc agattgaaaa 3763261 atcccagcaa gtgtaaatgt tttgtatcac agtaagaaga ccttcttatt aaaagaaggt 3763321 cttctgctat tctattcagt tatttcccaa aagccatcag cttcgtataa cttccaatat 3763381 aaagtgttcc gtcctcagcg agctgaggag aagacacgac gttgctgtcg gtttgatagc 3763441 tccataattc attgccgttt gcgtctgccg cataaacctt catatcatct gacccgaaat 3763501 aaaccgttcc cttcgcgtca atcagcggcg ccgttctgac agggccgtct gtgtagaatg 3763561 accagttcat atccccgttt ttgctgatgg aaaacagctc gccgcttcct gagccgatgt 3763621 agatattgcc attatgatca atcgcaggag atgagctgga gaacccgttt agcgggaatg 3763681 tccatttcaa actgcctgtt gatgtataag catacagctg tccatcttgg ttgccggcat 3763741 aaatgtttcc gtccttatca atcaccggat atcctttaaa cgcatttgac gtcgttctgg 3763801 accatttcac ctgtccggtt ccggagttga tcgcataaaa cacgtaatta tatgtgccga 3763861 catacacggt gccgtttttg gcaagcaccg gcacagagct gacgacccca tttgttttca 3763921 acttccagcg ctctgtccag gttgattttg acgtcggttt gatcgcgtga acataattat 3763981 caagtgttga gaaatacaac gtcccgtctg aaccgatcac cgtttcagag cttggcccgc 3764041 cgcttaacgg aaccgttgtt aaaatttctc ccgtttcttt gtcaataaaa taaatctttt 3764101 tgtcatagga tgccaaatag ataacgccgt tggtcccaag tacaggagat tgcgtatatg 3764161 tttttccaag attgcccgtc acccatttga ctgagccgtc tggattaaag gctttcattt 3764221 ccccgtctct ggaatgaaga tatactgtgc cgtctccgtc aatcacagcc cccgctccat 3764281 tttgcggagt cgttctgatg tcgttttgcc atttcagcgt cccgtctgta tttccggcga 3764341 accggctttc gcgtgaccag ttaaacatgg caggcgccat cgcttgtaca tcatatcttc 3764401 ctggcaaaaa gccagatgct ccattatttt gagaaaacac cgtttccgcc gcataagcag 3764461 ctgtcggctg aagcactttg gcagcgggca catcagaaac agcgccggcc gaaacagccg 3764521 ccgccaccgc agctcccgca atcaaagctt tcatacgaaa tgacttgacc atcattgaga 3764581 cccccattat atgtaacttc taatttgtga ccatcataac atattcatcc attttataaa 3764641 tctatttcac aaaaacatca caaactagaa aactatgtaa gagtattcac ggacgttttt 3764701 tcagcacccg atcgaaatgc agccacaaac caaatgacgt tgacagcagc cgcagcgaga 3764761 ctaactccca aaacaaagat cacctcagaa agcagatggt cactaaagaa actaaacatc 3764821 aagataaaac cggccgaaga caaatgaatc aaaagcccga agccgcaaag caccgccatg 3764881 acatacctca ttgcatcgac tccgagcata taaacgagaa atggaatgaa atacaagaca 3764941 aggatcatac cgacagctga ccacatgcca gctgaattaa actgattggc cgccgctccc 3765001 gttccggcca gcggcgaaag tgaagccgcc acaatcacgg cgcaaaaaag aaacgcagaa 3765061 atggttgtca tgatcgccac gctatttttt tttgacatca aactcctcct ttaatagaaa 3765121 tattaacctt ttttattata agtaagttga atgttatatt cattatattt ttaaaaaatt 3765181 ccagaataca tacacaaatg ctatgcttct ttctagtata tttatatagt aaaaaacaaa 3765241 ggataaaaga ctcatttttc tgtaatatca ggattttatc accataccat attgcatgta 3765301 catgtttttc aaagtatact attccagatt aattcagagg agagagaaaa atacatggaa 3765361 aaaccagcag gattttggat tcgtttttta gcttatttta ttgacggcat tattgtatct 3765421 gttcctagtt atattattct atttattatc aattctgtgt ttgtagctgg ggctgtggca 3765481 acaaaccctt acatgacgga agaagagtat ttagtgaaat acatgacgct tgcatttttg 3765541 cctactatgc tgatcatgat cgtcatcagc gtgttatatt acgggctgct cacagcttct 3765601 aaaatgcaag gcacacttgg caaaaaaatt cttggcctga aagtggtcaa tgaacaaggt 3765661 gaacgggttt ctgtcggaca gggaattggc cgttactttg cctatatctt atctggaatc 3765721 atcttttata tcgggtttat catgatcgcc tttggagaga aaaaaggcct gcatgacatc 3765781 atttgcaaaa cacgtgtcgt gtataaataa tagaaaaaag tctagacgcc aataggcatc 3765841 tagacttttg ttttctttgc aataggctgc cacgacagat acgtagcgct tctccacaac 3765901 cactcaaacg gccccatccg aaagacacga agccaaaggt ggctgaagac catttgaacg 3765961 gcacaaacag caattgtaat gagcacaccg gcagcagggt acacttttcc atacaggccc 3766021 aagccgtaat gataaaaaat ccaagtacac acaatagact gcatcaaata attggtaaat 3766081 gccatcctcc caacagcgga gaatgattgc agcactgttc tcactcttgt tttatgataa 3766141 agatagacaa ccgttgtaac atagaaaaac atgaggaaag gcgcgccaat cagcaaacat 3766201 atttctttat ccgttacact gtacagcacc tgggcgccga tgccgatgac aagcccagcc 3766261 atccataatc gttttaatcc tttgcgatgc ttttccggtt catgcaaata ccgtgatttt 3766321 gctgccgcag ctcccagcaa aaacatgctg aaatatggaa tggatgcaaa gaagtagttg 3766381 agcggattat acgtaagcat gccattcgaa gacatgtaaa caagacggtc gtggatccgc 3766441 tgttctgcaa tatccttcag gctgccgctt ccataaacat gaatcgcttg ttttgcctgc 3766501 tgtgttaccg cttgtaccca ttcctgtccg tttgattgat caaaacttgt caacatgaac 3766561 ggaatggaaa acagaagata caaagagacc gcccatatca gcagtgtttt cggctttgct 3766621 tttcgaaaca agagcaggac aaatccgagc agggcatatt ctgttaaaat atccccgtcc 3766681 catatcaaaa aggcatgaat cgttccaaac aagagaagcg ccattaacct tctcacatat 3766741 aacggaacaa accgtttccc tttgttttct gctctctcca tcatgacaac catgccaaat 3766801 ccaaataaaa aggaaaacaa taaaatacat tttgtttgaa tgaagaattt cagtatgtct 3766861 gcggcggcaa aatcagcttc agaccactta tccatgaaaa aattctcttt tccaagcata 3766921 gacaaataca tatccggata actgaaatgt gccagattga caaataagat gccgaaaatc 3766981 gccattcctc tcagcacatc aagcacaccg atccgctcat ttgttaaagt cggctgtaat 3767041 gaagacatag ccatcacgct ccttttttct gtaccttaag ggtaggaaaa aatgaagcgc 3767101 ggtaacatcg atttaggtgt caggccggca tgaaaacctt acaatcttgt catctttatg 3767161 gtttcatcac ctttaaatct aatgcttcga tattctgcaa aatgcgatca aagcgcaaag 3767221 cctgaggctc acatgggaag atgtggcctt catacgggtc gcctaacgtc cggaaaaacg 3767281 gttcaaataa accaggaacc aatacgccca ccatctttgt atagtgagaa tcaaggcgat 3767341 aggagtgaac ggtatttgca gggacatgca ggaaatctcc cggattcagc tgaatttcct 3767401 ggccatctgt ccacatcgtc atctggcctt caaggcaata aaatgtttct gtatgatatt 3767461 catggtagtg atcaacgatt cggtcacctt tagggccttc agatgatacg acgataaact 3767521 ggccatctgt atttttttgt gcagccacaa tgcggtgaag ctgatctcca gtcaacagac 3767581 gatctccttc tccagattca agaacgtatg gaaccgctcc atctggcagc tctgtaagtt 3767641 ccgctaattt ggccgaacat gcaggctttg cttcatctag aaatacaatg tccgctacag 3767701 cggctgcttc tgcaaatcgc tcgtttgaga cttcttcgct tgcgtacggc ggatgttcag 3767761 cgtgatcata cggattccca ataacggaat acaagtgcgc tacgtttcct ttcatcgtgt 3767821 aagacaccag tcttgttctg tggctctgca tccggtagct gtgcggtgtt cccgccggaa 3767881 tgttggcata atcacctgat attaataaat agcgttcacc atcaagtgtc agttccagtt 3767941 tcccgtccaa aacgagaatt ccttcatgtg tgtccttgtg gacgtgaagc ggaaaggcat 3768001 ctccttttcc cccggaaaga agcacgatct caaacaaatc acctgtgctc ctcccattcg 3768061 ccatcaccgt ggcaacctgt ctgccgaaca gatagcgctc gccttctccg ctccggagca 3768121 aataaggcat tttttcttta ggcaatgaat gtgtacataa tgttttcata ttatcgcttc 3768181 ctccaattta gaccagtcta tatattatca ttcatttgtc tagaccgttc tatataattg 3768241 taggagaaag gataacaaaa tgctaccctt tttttctcac cagcactggt atttgttcgg 3768301 caatgagaag aagaggcgtt ttgtctttat tcgttaacga aagcatgatg ccgccctcaa 3768361 tcatcgaatt aatcagcgtt ccaagctgat ttgcttcttc ttctgcaaat ccgttttcca 3768421 ttaattttct ggcaaaaacc gcttcccagc ttttaaacac cttcatgcaa accgtccgca 3768481 gcggttcact gattaacgct gtctcactcg ccagcaaacc gactggaata cctttaatgc 3768541 tttctgtgtt gtcaaattgg ctggctgttt ttttgataaa aagctgaatc gcttcaacag 3768601 gatcagagga ttcatccatg ctttgctgta tcagatgttc aacgatctta cctgtatatg 3768661 taaccgcttc aattgctagt tcttctttgc cattcggaaa aaagtgataa agcgatcctt 3768721 ttggagcacc gctttctttt acaatctggt tcaaacctgt cgcgtgatat ccttgcagct 3768781 ggaacagacg tgacgccgtg tgaaggattt tttcacgtga atctcctctg ctagtcatta 3768841 aaacattccc tcctaggtat ggtagagcga cttatataat ataaaaaaga accctgtgat 3768901 tgtcaaaagg ggtaagaccc ttccggatgg ggtaatgtac aaaaacagcg tctaggaggg 3768961 atctctcaat gacaatcgat cattcagtca caaatacaga gcagcttgaa caacagaacc 3769021 ccgccataaa aacaaagctc aaactgaaaa agcttaagga tcaggtgatc gtcattaccg 3769081 gcgcttcaag cggtatcgga cttgtcacgg cgagaatggc agctgaaaaa ggcgcaaagg 3769141 tcgtggcagc agcgcgaaat gaagaggcgc tgaaggagct cactgatgaa cttaaggaaa 3769201 aagggcacga cgccatatgg gtaaaggcgg atgtcggaaa agaagaggac gtcaaccgca 3769261 tcgcagaaac cgcgatcagc acattcggcc gctttgatac atgggtcaac aatgcggccg 3769321 tctcgacttt cggacacgcc atggacgtca ccgtcgaaga catgaagcgc atgttcgaca 3769381 caaatttctg gggacctgtt tacggaacaa gagcggctgt caaacactac accggcagag 3769441 gtgtgccggg cgcactcatt aatgtaggaa gcctgttcgg agacagggga acggtcattc 3769501 aatccacata tgcatctgcc aaatttgcgc ttcacggctg gacggaaagc atccgaatgg 3769561 agcttgaaaa ggaacaggcg cccgtctcgg taacgctcat ccacccgggc agaattgaca 3769621 caccatataa cgagcatgcg cacagctacc tcgacaaaca gccggctcat taccgctcca 3769681 tgatctatcc gccggaagcg gtcgccgaag cgatcctgtt tgccgccgaa caccctaagc 3769741 gcgacatgta catcggctca caggccaaag ccatcgccat gctgggcgcg ctttttcctc 3769801 gtctgaccga cagactgatg gaaaaaatca tgtatcacag ccagcatgcc gaaagaccgt 3769861 ccaatccgag agaagaaagc gctctttatg atgctggctg cggtatgcat gacagaggca 3769921 caaataaagg atggatgagg tcaagaagct actacacaaa agcgacgaag cgcccaattg 3769981 tatcggcggc tgttgttgcc ggactagtgg cttgggctgc cgccaaacga tgcagataat 3770041 ctctgaccat aagaaaaacc catgctgttc cagcgaacca tgggtttttc agctgttaat 3770101 cgataaaagc cttgttcata cgctgcagca gctcgccgaa catctctttt tcctgtgttg 3770161 accattcttt cagcatctgt tcataacgtt caaggcgctt ttgctgatcg gcttttaata 3770221 gttgtttgcc gagttttgta atggtaaaca ggctgactct cccatcagac gggtctgaga 3770281 aacgatagat gagctccttt gcctctaatg cagctgcttg tcttgaaaga gtagaaatat 3770341 caagcttaaa cgattcagcc aattccttaa cacgagcagg cccaaactca tccaattgtc 3770401 tcagtaataa gtacgaagat ctctccaaat tccctgttct tttctccgat tgatccagat 3770461 aaacagctct cctgataaaa gtcgtcagct catattcaat taattcaact ggattttgat 3770521 tttgcaatcg ctctcgctcc ctattccaat ctccggcatt gacaacatca tatatacttg 3770581 tataatacaa atgtacatta actgaataaa tacaagtcgt tatatgacta aatcaattat 3770641 tatacttgta tagtacaatc atataaaaag aaagtaaagc gattcctcag aaccatccta 3770701 gaagcaagca ccagaaagga ggaagctgtt ctgattggag agcagcactt gatgtgaaag 3770761 tcatacgaat tattttgcaa gtgttgatat tatatgtatt ttttatgatc ggggaagcca 3770821 ttcagcatct gtttcattta cccgtgtcag gaagcatcgt tggattggta ttgcttctga 3770881 tctgcttggg cctccgtatt gttcccgtct ccatcattga agacggagca gggtttttat 3770941 tatccttcct tccattgttg ttcatcccgg caatgacagg agtgataaac tatccgtctc 3771001 tcatttcatt caatggcctg atgctgctga ttacagtcgt tctcagcacc atcgtcacga 3771061 tcattgcggc tggattcgcc agccagctat tagagaaaaa agcaaaaaaa cgggaggaga 3771121 aagagaaatg cagcaagcat gtatcgcgat cattataatt cttttaacag ttgccgctta 3771181 tttagcgatg gtcaaactct ataagcgatt cccgcttcca tttctgatcc ctgttctgac 3771241 aacgacaatt ttgattgtag cggctttgat gatgtttcat gtttcctatg aaggctatat 3771301 gatcgggggg aaatggatca attctttgct tgggccggct gttgtggcgc tggcctatcc 3771361 gctttataag caatggcata tcattgtcaa acattgtgtt cccattttag gcggcgtcct 3771421 ggtcggctta tgcatgggaa tgatcagcgg gctgatcttc gcagaagcat tcgggattga 3771481 tcatgatctc ttattatcca ttctgccaaa atcgatcaca acccctgtcg ctattcagat 3771541 cgccgccggt cttggcggcg tcccttccat gacagtcgta tttgtcatga ttgcgggctt 3771601 ttcaggcgtc atcctcgggc cgcttttcct aaaatggctt cgcatacgca gctccctagg 3771661 acaaggcatt gcattaggca gcgcctccca tgcactgggt acctccaaag cgttggaata 3771721 tggggaattg gccgtatcca tgagttccgt ctccatgacg ctttgtgcgg tgctcggctc 3771781 attcttcggc ccgctcgtcg tctggctgtt tcatatttaa caaagaaaga ctgccccggg 3771841 ggagggcagt ctttttcgtt taagaagcaa aaaaatcaat caacggctga aagtccttag 3771901 ataaatcaac gtcattcggt tctgcttgaa gcaggcggtc aatcatacgc tccagctcct 3771961 caacatcatt cttatccgta tattcaatga agtttaagct ttcaagccaa tcccgatatg 3772021 aatgtttggc tttgccatag ctgtttccaa agacaaggca aggtgttttg gtgataatcg 3772081 agaaaatcat cgcgtgaagg cggtcggtaa tcaccaattt actggagccg atgcggtcca 3772141 gcatctccat aaaatgcttt tcacgatcag cgtaatcgat ggtgtctacc gtatccagca 3772201 ccgtatcggt acgctctgtg taagttgttt tttctgccca ttgcttcatc tgtgaaataa 3772261 aatcttcgtc agtcactttc tccttatccg ctcttaaaat aaagagaacg ccgtcccgct 3772321 cgagctctcg cggcacaata tccaaggaaa gcaccatgtc cggtgtaaag atcacattgg 3772381 agttgaaggt ctctttcaca acatccagtg tttgcgtctc acgcgcagca atcgttaagt 3772441 ttgtattttg atggtacgca tcctgtgttt ttttcttttc cttctgtcct tcctctgtat 3772501 cctcaaaata aacggattgt ggcagagaaa ttgatttgta gtctttaaac gccgaaaaga 3772561 cctttcttct gtcttcctca atatcgagat aaaggtttcc taaattccct ccgcctgtaa 3772621 agcagacaat atcgtcttca cgaatgatct ccttcaccag ttcaatgccc tcatccgtcg 3772681 cataatccat aatctcaatg tattcataat acggaaaatg atttttgata aatttctctt 3772741 ccgcatacgc aatcgcttgg tcgccaatgt ttgtgtagct aggggaacca aacaaaaata 3772801 cttttcgttt atcatttaac agagcttccg gctccacatt tggcgcaatg ccttttacta 3772861 gttttttgcc tttgatttct tgtacagtca tatctgcgtc ctccttctgg gatgaattcc 3772921 tcattgtgtg ttaactgtct ctacccaaaa agaaggatgg ctatgcattg gcatgtgcat 3772981 cggctatatc agaaacatcg ttttcgccaa tttgatagac gctgcaatgt cccgcgccgt 3773041 tctttccata tattccgcgg catgttcaaa cgcgtcttct agtggcacgg ctccggggac 3773101 gatgctgaaa agcgcatcga ttccgtgttg atagacggca ttactgtctc gggaaattga 3773161 tcccgcaatg ccgataacgg gcacatcgta tgatttagcg gccttggcca ccccgatcgg 3773221 tgtttttcca tgaaccgttt ggctgtcgat tcgtccctcg ccggtaatca caaggtctgc 3773281 atcctgaacg atactttcaa aatcaaccgc ttcaaggaca atatcaatgc ctcttttcag 3773341 gtcagcctga agataagtta gcaggctcca tccaagaccg cccgctgcac cggcgccctc 3773401 tgtatctcgg aaggttgatc cgagcgcttt ttctgccata tcagcgaaat ggcttacgtt 3773461 ctggtctagt acatccaaca tgtcggccgt cgcgcctttt tgcggcccga aaacagccgt 3773521 agcacccttt ggtcctgtta acggattgtc cacgtcacag gcaacttcca gtttgacatt 3773581 ccgcaatctg gaatcaagcc cgctcacatc tattgatgca agctgagata acgcgccgcc 3773641 ccctgggcca atctcgctgc ctgagttatc aagaagcctt ccgcccaatg cctgaatcat 3773701 cccggctccc ccgtcgttcg tggcgcttcc gccgattccg atgatcaatc gctccgctcc 3773761 cgcatcaaga gctgctccga ttaattctcc cgttcccctt gttgtagtga tgagcggatt 3773821 tcgcttatct acaggcacca gatgcagccc tgaagcagca gccatttcaa tcacagctgt 3773881 tctcccatct cccatcatgc caaagaaagc tctcaccggt tcccccagcg gccctgtgac 3773941 aacttgctct atgatccttc cattggtcgc atcgaccaga gattgaacgg ttccctcgcc 3774001 gccatccgcc accggcaatt ttctgtaatc agcacccgga aagaccgatt tgaaacctct 3774061 ttctatcgct tcggctgcct ccagagctga taagctttcc ttaaaagaat caggtgcaat 3774121 gatgattttc atccaaatcg cctctttcaa aacatgattc acttaaccta ttgatctcca 3774181 atgtaccata attgatctgg aaatacatac catgcaatat ggtaaaaatt taaataaaaa 3774241 ttagaaatga aagtgtttgc ataaaagaaa tattcacgtt atcatacttg tatacaagta 3774301 tactccttga gtgaggaagg tgagtgtatg ctagactcca aagacctgtt gtatcccgca 3774361 aaatggctct caaaagcgtc aaccggagtt cgtgtcgcat acgagctgag aatgcggatc 3774421 gtttcaggtc tgattgaaag cggtaccatt ttatcagaaa atacaatcgc cgccgagttt 3774481 tcagtaagcc gttcgccggt tcgcgaagcg ctaaaaatac tcgcatccga aaaaatcatc 3774541 cgcttagaac gaatgggagc ggtcgtaatt ggtttaactg agaagaaaat cgcggaaatt 3774601 tatgatgtgc ggttactatt agaaacattt gtctttgaac ggcttgtcaa aatagacatt 3774661 gagcctttag ttaaggatct cagcaaaatt cttgaaatga tgaaagtctc aatcaaatat 3774721 gaggatgctg acgaattttc atttcaagat gtgctgttcc atgaaacgat tatccgagcg 3774781 attgatcatt catacattca gatgatctgg aacaatctaa aacccgtcat ggaaagcttt 3774841 attcttttat cgatgcgggt acggttaaag gaaaagtatg aagacttcac aaggatttta 3774901 gataaccacg agctttatat tcaagccatc aaaacaaagg atagggcgct gatgattcag 3774961 tctcttcacc aaaactttga tgatgtgcag gataaggtag aagacctatg gctctcacaa 3775021 caaatgctgg caaaaggagc tgaatacaac aatgactagt tatatgttag gaatcgatat 3775081 cggcacgaca agcacaaaag ctgtgctgtt cagtgaaaac ggagatgtgg tacagaaaga 3775141 aagcatcggc tacccgctct atacaccgga catctcaaca gctgaacaaa atccggaaga 3775201 gatttttcag gcagtcatcc atacaacagc gagaattaca aaacagcatc ccgaaaaacg 3775261 gatctctttc atttcgttca gcagcgccat gcacagcgtc attgcaatcg acgaaaatga 3775321 caagccgctg acgccatgca ttacatgggc cgacaacaga agtgaaggct gggcgcataa 3775381 gatcaaagag gaattgaacg gacatgaggt gtacaaacgg acgggaacac cgattcatcc 3775441 gatggcaccg ttaagtaaaa ttgcctggat cacgaatgaa agaaaagaaa tcgcttccaa 3775501 ggcaaaaaaa tatatcggca tcaaagaata catttttaaa cagctgttca atgagtatgt 3775561 catcgattac tcattggcat cagcgacagg catgatgaac ctgaagggct tggattggga 3775621 cgaagaggca ctgcgcatcg caggcatcac gccggatcac ttatccaaac tcgtgccgac 3775681 aaccgagatc tttcagcact gcagcccgga aatagcgatc caaatgggaa tcgatccgga 3775741 aacgcctttt gtcatcggcg ccagcgacgg cgtgctgtcc aacctcggcg tcaacgccat 3775801 taaaaagggt gaaatcgccg tcaccatcgg tacaagcggt gccattcgga cgattattga 3775861 caagccgcaa accgatgaaa aagggagaat tttttgctat gccttgacgg acaagcattg 3775921 ggttattggg ggacctgtga acaatggggg catcgtcctt cgctggatca gagacgagtt 3775981 tgcctcctcc gaaatcgaaa cagcgacacg gctgggcatt gatccatatg acgtgctgac 3776041 gaaaattgcc caacgcgtca gacccggttc tgacggtctg ctgttccacc catatctcgc 3776101 cggagaacgc gctccgttgt ggaatccgga tgtacgcggc tcatttttcg gcttgaccat 3776161 gtcgcataag aaagagcata tgatacgcgc ggcattggaa ggcgtcattt acaacctgta 3776221 cacggtgttc ttggcgttaa ctgaatgcat ggatggcccg gtaacccgca tccaagcgac 3776281 agggggtttt gcaaggtcgg aggtttggcg ccaaatgatg tcggatatct tcgaatcaga 3776341 ggttgtcgtt ccggaaagct acgaaagctc atgtctcggc gcctgcattt taggcctgta 3776401 tgcaacagga aaaatcgatt ctttcgacgc cgtgtccgat atgatcggca gcacatacag 3776461 acatacgccg atcgaagact cagccaagga atacagaaca ttaatgccga ttttcatcaa 3776521 tctatcaaga ttattagaaa atcaatatac acaaattgca gattatcaga ggggcttaat 3776581 cacacacaaa tagtacatga catgaagggg agggcattac catgccgtta atcatcgttg 3776641 cacttgggat cttagcatta ctatttctga ttatgggctt aaaattaaac acatttattt 3776701 ccctgctggt cgtatcgttc ggcgtggcac tggcactcgg gatgccgttc gataaagttg 3776761 tcagctccat cgaagcagga atagggggga ctcttggcca catcgcgctc atcttcggac 3776821 tcggtgcgat gctgggcaaa ctgatcgcgg attcaggagg cgcacagcgc attgcgatga 3776881 cgctcgtcaa caaattcggt gagaaaaata ttcaatgggc cgttgtcatt gcctcattca 3776941 ttattgggat tgcgttattt tttgaagtag gactggttct attaattccg attgtctttg 3777001 cgatttcaag agaattgaag atttctattt tatttctcgg aatcccgatg gtcgcggcac 3777061 tatccgtcac acacggtttc ctgccgccgc acccgggacc tacggcgatc gccggtgagt 3777121 atggcgcaaa cattggagaa gtgctgctgt acggctttat cgttgctgtt ccgacagtgc 3777181 tcattgcagg gccgttattt acaaagttcg cgaaaaaaat cgttcctgca tcatttgcga 3777241 aaaacggcaa tattgcatca ctcggcacac aaaaaacatt taaccttgaa gaaacacccg 3777301 gctttggaat cagtgtcttt actgcaatgc tcccgattat catcatgtcg gtcgcgacca 3777361 ttatcgacct gcttcaagaa acaatcgggt ttgcagataa cggagtttta gcttttatca 3777421 gattgattgg aaacgcatcg actgctatga ttatttcgtt attggtcgca gtctatacaa 3777481 tgggcatcaa gcgcaacatt ccagtcaaaa ccgtgatgga ttcttgttca actgccattt 3777541 cacaaatcgg catgatgctt ttgatcatcg gaggaggcgg cgccttcaaa caagtgctga 3777601 tcaacggcgg tgtcggcgat tacgtagcag acttattcaa aggaacggca ttatcgccaa 3777661 tcattctggc atggctcatc gcagcgatcc tgcgcatttc tctaggatcg gcgactgttg 3777721 ccgcactaag cacaacaggt ctggtcattc cgttattggg ccattctgat gttaacctgg 3777781 cgttagtcgt actcgcaaca ggagccggaa gtgtcatcgc ttcacacgtc aatgacgccg 3777841 gcttctggat gttcaaggaa tacttcggat taagcatgaa agaaacattc gccacatgga 3777901 cattgctgga aaccattatt tccgttgctg gactgggatt cattttattg ttaagtttag 3777961 ttgtatgaaa ttaagaagga gctgtaacac atgttcaatt cgattggtgt cataggctta 3778021 ggcgtaatgg gaagcaacat cgccttaaac atggcaaata aaggcgaaaa cgtcgctgtc 3778081 tataattaca ccagagattt aacggaccag cttatccaaa agctggatgg acaatctctc 3778141 agcccgtatt acgagcttga ggactttgtt caatcgttag aaaaaccaag aaaaatcttt 3778201 ttgatggtca cagcgggaaa acccgtagat tccgtcatcc aatcattaaa gcctttgctt 3778261 gaagaaggcg acgtcatcat ggacggagga aactcccact atgaagacac agaaagaaga 3778321 tatgacgagc tgaaggaaaa agggatcggc tacctgggag tcggcatttc cggcggtgaa 3778381 gtcggtgcgt taacagggcc ttccatcatg ccgggcggag atcgcgacgt ctatgagaaa 3778441 gccgctccta tcctgacgaa aatcgcagcc caagtcggag atgacccttg ctgtgtctat 3778501 atcggaccaa aaggggcagg gcactttaca aaaatggtgc acaacggcat tgaatatgcc 3778561 gacatgcagc tgattgcaga agcttatacg tttctaagag aaacgcttcg tctgccgcta 3778621 gatgaaattg catctatttt tgaaacatgg aatcaaggtg agctgaaaag ctatttaata 3778681 gagattacag ctgagatttt acgcaaaaaa gacgaaaaaa caggacagcc tctgatcgat 3778741 gtcatccttg ataaaaccgg ccaaaaaggc accggaaaat ggacgagcat gcaggcgatt 3778801 gataacggca tcccgtccac gatcatcaca gagtccttgt tcgcccgcta cttgtcatct 3778861 ttaaaagaag aacggatggc agctcaagat gtattagcag gcccggaagc cgaagaaaaa 3778921 cacttggata aagacacttg gattgaatac gtcagacagg ctctttacat ggggaaagta 3778981 tgcgcctatg cacaaggctt tgcccaatat aagatgtcat ctgagcttta cggctggaat 3779041 ctgccgctca aagacatcgc cttgattttc cgaggcggct gcatcatccg cgctgatttc 3779101 ctaaacgtga tcagcgaagc attcagtgag cagccaaatc tggctaacct gctgatcgcg 3779161 ccttatttca cagataagct ccatgcctat caaacaggcc tgcgaaaagt cgtttgcgag 3779221 ggtatcagca ccggaatctc tttcccatgc ttaactaccg cgctctctta ttacgacggc 3779281 taccgcacag ggcgttccaa tgcgaacctc ttgcaggcac agcgcgatta ctttggcgct 3779341 cacacgtacg aacggactga tatggacggc gtcttccata cgaattggtc tgaataacct 3779401 gtattaaaaa cacggtcagt ttcaactgaa ccgtgttttt ttcttctatc ccaaacaaca 3779461 gaagacataa gttatgtttt aaatatcata aacagtgata caataatagc tagaaacaat 3779521 ccccaagatc atcatgtgac agcagattgc tgttccgttc tattctgctt ttggccattg 3779581 tcctttgccc ttgaccatgg tgtcataaaa tgttcaaatg ccaaaacggc ctggcattct 3779641 gatttacaaa agtccctgaa aaccttatct aattgagaat cagcctctca tttattataa 3779701 aagaaatgcc taaatcctac ctgtcacacc tttattaaga tgaaaaaaag taggttatgg 3779761 cttgacaaaa aatatatatt aattaataat tcatatataa ttagaattat tattgaaagc 3779821 gattatgctt tctaatacat ttttaggagg aatatacatt atgtctttaa tcggtaaaga 3779881 agtacttcca ttcgaagcaa aagcattcaa aaacggtgaa ttcatcgatg taacaaacga 3779941 agatttgaaa ggccaatgga gcgtattctg cttctaccca gcagatttct ctttcgtatg 3780001 cccaactgag cttgaagatc ttcaagaaca atatgctgca cttaaagaat taggtgttga 3780061 agtatactct gtttctacag atactcactt cgtacacaaa ggctggcatg acagctctga 3780121 aaaaatcagc aaaatcactt acgcaatgat cggtgaccca tctcaaacga tctctcgcaa 3780181 cttcgatgtt cttgacgaag aaactggcct tgctgaccgc ggaacattca tcatcgatcc 3780241 agacggcgtt atccaaactg ttgaaatcaa tgcaggcggt atcggccgtg acgcaagcaa 3780301 ccttgtaaac aaagtaaaag cagctcaata cgttcgtcaa aacccaggtg aagtttgccc 3780361 ggctaaatgg gaagaaggcg gcgaaactct tacacctagc cttgatctag taggtaaaat 3780421 ctaaggagtg cattcaattg gtacttgatg caaatatcaa agcacaatta aatcaatata 3780481 tgcagctaat tgagaatgac attgttctca aagttagcgc aggcgaagat gacacttcta 3780541 aggacatgct ggctctcgtt gatgagctgg cttccatgtc atcgaaaatt tcagttgaaa 3780601 aagctgaatt aaacagaacg ccgagcttca gtgtcaatcg tgtcggagaa gacactggcg 3780661 tgactttcgc cggtatccct ctgggccacg aattcacatc attagtgttg gcgttgctcc 3780721 aagtgagcgg cagaccgcct aaggtagacc aaaaagtcat tgatcaggtg aagaagatca 3780781 gtggtgaata ccacttcgaa tcttatatca gcctgacatg ccacaactgt cctgatgttg 3780841 tacaagcttt aaacatgatg agcgtgctga acccgaacat tacgcacacg atgattgacg 3780901 gtgcagcata caaagcagaa gttgaaagca aaaacatcat ggcagtgccg accgtttacc 3780961 tgaatggcga atccttcgga agcggccgta tgacgcttga agaaattctt gcgaaaatgg 3781021 gcagcggcac agatgcatct gagtttgctg acaaagagcc gtttgacgtt cttgtggtcg 3781081 gaggcggacc tgctggtgca agtgcagcga tctacactgc acgtaaaggc atccgaactg 3781141 gtgttgtcgc tgagcgcttc ggcggacagg ttctcgacac catgagcatc gaaaacttca 3781201 tcagcgtcaa agcgacggaa ggaccgaagc tagcggcaag tcttgaagag catgtgaagg 3781261 aatatgatat tgatgtcatg aaccttcagc gtgcgaaacg ccttgagaag aaagatctgt 3781321 tcgaacttga actcgaaaac ggcgctgtcc tgaaaagtaa aacagtgatc ctttcaacag 3781381 gtgcacgctg gcgcaatgtc aacgtccccg gtgaacaaga gttcaaaaac aaaggtgtcg 3781441 catactgccc gcactgtgat gggccattgt ttgaaggcaa agacgttgcg gtaatcggcg 3781501 gcggaaactc tggtatcgaa gcagcgattg atcttgcagg tattgtcaat cacgttactg 3781561 tactagaatt cgcgccggaa ctgaaagcag acgaagtcct gcaaaaacgt ctctacagcc 3781621 tgcctaacgt tactgtcgtg aaaaacgcac aaacaaaaga aatcacaggt gatcagagtg 3781681 ttaacggcat cacatatgta gaccgcgaaa caggcgaaga aaaacacgtt gaacttcaag 3781741 gtgtattcgt ccaaatcggt ctcgtgccaa acacagaatg gttagaagga acggttgaac 3781801 gcaaccgcat gggcgaaatt attgtcgaca aacacggcgc aacaagcgta ccaggcttat 3781861 ttgctgccgg cgactgcaca gacagtgcgt acaaccaaat tattatttct atgggatcag 3781921 gtgcaactgc cgccctcggc gcgtttgatt acctaatccg taactaatat aagaaatccg 3781981 ctatattgcc agattggcag gatagcggat ttttcttttt ctacagaaaa aaaccgaacc 3782041 aggcactacg gtaaaagtgc tcgattcgag cgcttcttat agttcctcac cattcgtttg 3782101 aatgacattt ttataccact caaaggagtc tttcttatat cgtttcatgg atccgtttcc 3782161 ttcattgtca cgatcaacat agatcatgcc gtagcgtttt ttcatttcgc cagttgtgaa 3782221 ggagacaata tcaataatgc cccacggcgt gtagccaatt aaatcaacac catcgtacgt 3782281 gaccgctttt ttcaatgctt caatatgcga ttttaaatat tgaatgcgtt ccggatcatg 3782341 aaccttgccg tcctcctcca gcgtatccac tgcgccaaag ccattttcaa cgatgaataa 3782401 cgggatttgg tatcggtcat aaaaacgatt taacgtatat ctcaacccgg ttggatcaat 3782461 cgcccatccc cagtcactcg aagtgatgta cggattttcg acaccattcg gcaagccgcc 3782521 atttacaata tcgccagtgt tatcattttt cacatcgctt ttcacagttg ttgacatgta 3782581 atagctgaag cctaagtaat cgacggttcc gtttcttaaa atctcatcat cgccgtcttc 3782641 gaatgtgatg ttgtagcctt cgcgttcaaa ttccttcaac gcgtagcttg gataataacc 3782701 gcgaacctgc acatcaggga agaaatagcg ctgcctcatt tcttcttcag ccagcatcac 3782761 atcttcagga ttggaggaga aaggataaat cggcacgtgt gataccatgg ccccaatctg 3782821 gaactctgga ttgatgtctt ttccttttgc cactgctaag gcgctcgcca ctaattcatg 3782881 gtgcgccgtt tgatacatga cttccttggc gttttcgttt tcgccaacca caacacctga 3782941 attcgtccat aggaacagcg gattgttcac atccatttgg ttgttaatct cgttaaatgt 3783001 catccagtac ttcactttat ctttgtaacg ggtaaagcaa gcctctgcga agttgacgaa 3783061 gaagtccacg actttccggt ttctgaagcc gccatattct cttgccaggt gcagcggcat 3783121 ttcaaagtga gacagggtaa tgaccggctc gatcccatgc ttcagcaatt catcaaacac 3783181 atcatcataa aactgcaaac cagcttcgtt cggttcagcc tcatcgcctt tcggaaaaat 3783241 ccggctccag ccgatggacg tccgcagaca ttttaatccc atttccgcaa acaaagcgat 3783301 atcttccttg tatctgtgat agaaatcaat ggcttcatgg tttggataaa attcgttttc 3783361 ttcaatcgtg tcagtgattt ttctcggcac gccgtgcgca cccgctgtca tcacatcgac 3783421 gacactcggc cctttaccgc cttgattcca tccgccttca aattggtggg cagctaaagc 3783481 accgccccat aaaaaatcct ttggcatgtt tcccatgttt aattcctcct cagcttacga 3783541 ctgtaaatat tttttgatgt aatgcacttt cctcaatgtc ttcaatgaaa gctttatcaa 3783601 actcaacaag cacttcgcct tttttgacgg tatcgccttc ttttaccttc aaggaaaaag 3783661 gcgtgccgtc aaatgtcacc gtatccagcc cgatgtgcgc aagcaattcg acgccggacg 3783721 ctgaacgcag gccaatcgca tgctttgtag gcgtaaccat gacaaccgta atgacgccgg 3783781 gatggtagca tcgatttcac gatatccttc gctttagggg tagaccgctt cagcaccaat 3783841 cgaagtctgg tagcgcagcg agaagcccca atcacattct cttccccgcc tacggcctct 3783901 aaaatgtctt ttgctagtct cgtataatct ctcactttcc ccgacatttc acccacccct 3783961 tcgttttggt tacgctttca ttataattgt aacggtataa tttatcaatt ccgaaacaaa 3784021 atatttacgc actaactatc attgtaagcg gtttatgcta taattttgac aagtgaaact 3784081 aaacgaataa atgaggaatg cgtatgttaa aataccagca aatcgcaacg gaaattgaaa 3784141 catatataga agaacaccag cttcagcagg gagacaaact gccagtccta gaaaccctca 3784201 tggcccagtt tgaagtcagc aaaagcacca tcacaaagtc cctcgagcta ttagagcaaa 3784261 aaggcgcgat ctttcaggtc agaggaagcg gcattttcgt cagaaaacat aaacgaaaag 3784321 gctatatcag ccttctgtcg aatcagggat ttaaaaaaga tctcgaggat ttcaacgtca 3784381 cctcaaaagt catcgaactg gacgtgagaa agccaacacc ggaagcggcg gaaaacctga 3784441 acatcggaat ggacgaggac atctactatg tcaaaagggt ccgctacatc aacggccaga 3784501 ccctttgcta cgaagaatcc tattacacca aatccatcgt gacgtattta aacaacgaaa 3784561 tcgtctccca ctccatcttc cattacatcc gggaaggact ggggttgaag attggttttt 3784621 ctgatttgtt tctgcacgtg ggccagctta atgaggaaga agcggaatat ttgggattag 3784681 aggctggact gccgaagctg tatatagaaa gtatttttca cctgacaaat gggcagccgt 3784741 ttgattactc gaagatttcg tataattatg agcagtcgca gtttgtggta caggctaata 3784801 gttttttatt atagggctct tcactacggt aggtggtcga catgtacaaa attatcattc 3784861 ctgccatact agccatcttt gcgctctgga tactcttaca gatttcacta gagatgagca 3784921 tcgttaagaa tccaatgaac tactttatcg tattcattat ctttttcctc tttgtaaaga 3784981 tggtgaaaga aaaacaataa tagtttgggc gatgcaaaca gaaaaacatc cttcccttaa 3785041 caaactcagc cagtcacatg cattaatctt gatgttaatg atatataggt gcacataaaa 3785101 agctacttca ttgtgaagta gctcccttta ttaaaggccc attttgatcc atctagtttt 3785161 agaaaagcga aggacaatcg catttatgat aataattgaa actaaataca aaataataaa 3785221 taaaacatca ttactcccaa gtgtcatgtt atcagattgc agcactcttt ctattcgggg 3785281 gtacatagtg ttacctgcct caaaaggagc aatgaaacca aacgttttat tgcttatagc 3785341 tactaagata acagaagtca tccaataaac gatactgaca cctatactaa ttaatatatt 3785401 aggacataac acgcttatag ttccgataat tagaatatac tgcagtataa ctgcagaaaa 3785461 taaaaaaagt aataatgcaa aatgcgaaaa atcatggtac atcaacgata tgattagcag 3785521 gcctagcgtt ataaatgcaa aacattctaa aaataaaaca gctatctttt tataaaagaa 3785581 agtatagatg ttctctccaa ttaacttgta aaagagaata tttttgtttg aatactctct 3785641 attaataaag aaagctataa caaatgaaaa taacatcaaa ccaaactggg tcgcaacagt 3785701 ataggagcta aagaaaaaca tttcaggtgt aacattactg actttatcga ttccaacaag 3785761 taaaaaataa cccagcaaaa ataaaaatac aaacattgct cctaaaataa tgataacttt 3785821 gttgctaata ctctttttaa actctaattt catctcaagc ccccactgtt ttattactca 3785881 tttatataca cttcaattaa tttatccact gaatgatatt gttgaatttc ttggtgatta 3785941 aatatataat aatccccttc tatcgccttt aaatcagaca aatcatgtgt aatgttgatg 3786001 ataatcttct cggggttctc ctgaatatac ttgtttaaga agccatgaat ctctataacc 3786061 gtttttttgt ctaatgaatt cgttatttca tctaaaacaa taatattttt atcctctaat 3786121 aagaaactga gcaattttaa tttttgcttt tgtccatcac tcaaattttt gatcagaact 3786181 tttccatcaa tattatccag attaagtaaa tatgcgattt tatctatcat ttttgcatca 3786241 aattttttac tcaaaaagtg taataaaaag tccttagaaa catcattagg tatattcgac 3786301 gagctggata ttaaagaaac attttgacga atatctctgc cgattctttt gctattattc 3786361 aacaaaaagt ctttagcaag ctgtgattta ccgactccat tttttccgac aacgtgatta 3786421 attttcccgc tcgaaaaatg caagtcggtg tcctgaagta acgttttgcc tttcactttt 3786481 aaagtgtaat tcgctatatt catatacata ctcctaggaa atatttgcat aataataaaa 3786541 tgttctgcct tgtgatttgt tactaatgtc taagcttttg aggtacctct ttcgtttccg 3786601 atccggaagc gaaagaaatg tttttagatg gctaatttgg agatctttta ctctagttta 3786661 caatatataa tatccaatgt acaactgaat tcactgcaag gccaatccct ataatttgaa 3786721 tcgtaagaac taaccaatga tttgtcttaa aacggctata ttcatctaag ctcagaaaag 3786781 ctaaaagaat tttgtaacca tcagaattca atattgggat taagttccac aataaagtag 3786841 acgagaaaag cataaatgcc atagttaatg cttcactgga aaatgtaaat tgatttatta 3786901 attctaatgt atttattaaa agataattga taaacaagcc aaataaatga acgattatct 3786961 tttcatttct tgatagcatg taggtttcat tcaattggac ataaaaagca ggaaatacat 3787021 aaaaattcag tttgaatccc actttatcaa agtttttccc gaaaaatttt aaggaataaa 3787081 tatgtcccag ttcatgaagc actatattca ttataaaata aataactata attatccaca 3787141 ttttccagcc gtaaaatact gaggacaatc cattttgcaa ttttattaaa tgaatataat 3787201 ttaatatgaa catgagagcc gtaaaggata agaacagata aaaaaacttt ggtgatactt 3787261 tctctttata cattttaaaa cgtaataatt gtttatctga cagagaattt aaactatttt 3787321 tatagtattc tccgcttttt ttgtctttta taaatacgtt gttttgcaca agcacttcat 3787381 atttttcatc ttcatacttt aaaattttca ttatagtatt tttccatata aggatagaag 3787441 tagtttattt tttctgcaga gttgaataag gaaccacaaa ctccacaaat agaggaaaat 3787501 tcataaggaa tgtcaaattc ctctattttg ttattttctt ttaaaatatt caaaaaccat 3787561 ttgaatcctt cttttctaag aataaataat agcaaattgg aatttaactt ttccacggtt 3787621 ctttcgaaac tttggttata ttcttccctt agggttattt tcgtttcaaa aatagcaggg 3787681 gaacaacatg gataaatttc tccatcatga tgatatacaa tgtcatatcc gggacaatgt 3787741 aaggaatctt catcttcaag actgtaaaat ttatgtatgt tttcttgctt aattctagtt 3787801 ttagcagcgc caactgatat cattggaaat tttgttatct ttacacctaa gattgaatcc 3787861 cccaattcct ctaaaatgtg gttggacatt ttgtctttgg taactgccat attaagagaa 3787921 atatcgatat cagggtattt cctgctatgt tctaatatgt ttttaatact ggaagacttg 3787981 acaaatggag catggtactc atcataactt atagtcagtg ctatcacatt taaagaattc 3788041 atatcatgaa agtactcctg gacctttttc ttgctcaaac cccaaaatcc attagagatc 3788101 aacgttattt gtttttcata tggtttaatg atttccatta gttcttttaa aaatttataa 3788161 tctaaaaaaa cttccccacc tgtaaaagaa atcacttgaa tggttttgtt ttttgcaaat 3788221 tcagttacta actctcttat gtattctttt tccatcctgg ttgttgaagt tggtgaacta 3788281 gaaaaacaac aatggtcaca ggatgcatta caccttgaat ctaaattgat tgatactgtt 3788341 ttattataca tgaaatatcc cccaacaaat ggtaaaggag agttagactc tcctttgtac 3788401 ccctctaatt aatgaccact tccaagaatc cagcgatttt cttttgattt tacaaaatac 3788461 caaagatcat tcacttttgc taacttttgt gattcatcta atagaccctt aaattctaag 3788521 tttttcacag tctcattgtt agtgatttcc tttttcatat tatccctcct ccttttctaa 3788581 tataaaccaa ttattctata tcattcaata catgtcaata tattgtacct aaaaaatctg 3788641 aaaaatgtca ctattcttgg tatataaagc ctatagtcct ctagcccctc taagctatac 3788701 cgaatgaaag gccatagttt gatttaaagc ttcgtaatga aaagtaaaac atcaatattg 3788761 actacactag ttaagggata tacagatttt aagtggaaga aatgaggcaa acaatcttac 3788821 cctaaaccaa cctgtactga aaagctgttt taagctcttg cttaccccat ttggcacctc 3788881 tttctctcgt tttaattgtc tctaaaagca gttatgcggt actatcatat aaaggtccaa 3788941 tgtttaaaaa taatgtcata cttttaaatt caccttatca tgcacatgct cataaagagg 3789001 ggtttattct aaaaagggga tggacggttt tggaaagcaa gtacctagat ctactcgcac 3789061 aaaaatacga ttgtgaagaa aaagtggtaa cagaaatcat caatttgaaa gcgatattga 3789121 acctgccaaa aggcaccgag cattttgtca gtgatctgca cggagagtat caggcattcc 3789181 agcacgtgtt gcgcaatggt tcaggacgag tcaaagagaa gatacgcgac atcttcagcg 3789241 gtgtcattta cgatagagaa attgatgaat tagcagcatt ggtctattat ccggaagaca 3789301 aactgaaatt aatcaaacat gactttgatg cgaaagaagc gttaaacgag tggtataaag 3789361 aaacgattca tcgaatgatt aagctcgttt catattgctc ctctaagtat acccgctcca 3789421 aattacgcaa agcactgcct gcccaatttg cttatattac ggaggagctg ttatacaaaa 3789481 cagaacaagc tggcaacaag gagcaatatt actccgaaat cattgatcag atcattgaac 3789541 ttggccaagc cgataagctg atcaccggcc ttgcttacag cgttcagcga ttggtggtcg 3789601 accatctgca tgtggtcggc gatatttatg accgcggccc gcagccggat agaattatgg 3789661 aagaactgat caactatcat tctgtcgata ttcagtgggg aaatcacgat gtcctttgga 3789721 tcggcgccta ttccggttcc aaagtgtgcc tggccaatat tatccgcatc tgtgcccgct 3789781 acgacaacct ggatattatt gaggacgtgt acggcatcaa cctgagaccg ctgctgaacc 3789841 tggccgaaaa atattatgat gataatccag cgttccgtcc aaaagcagac gaaaacaggc 3789901 cagaggatga gattaagcaa atcacaaaaa tccatcaagc gattgccatg atccaattca 3789961 agcttgagag cccgattatc aagagacggc cgaactttaa tatggaagag cggctgttat 3790021 tagagaaaat agactatgac aaaaatgaaa tcacgctgaa cggaaaaaca tatcaactgg 3790081 aaaacacctg ctttgcgacg attaatccgg agcagccaga tcagctatta gaagaagaag 3790141 cagaagtcat agacaagctg ctattctctg tccagcattc cgaaaagctg ggccgccata 3790201 tgaattttat gatgaaaaaa ggcagccttt atttaaaata taacggcaac ctgttgattc 3790261 acggctgtat tccagttgat gaaaacggca atatggaaac gatgatgatt gaggataaac 3790321 cgtatgcggg ccgtgagctg ctcgatgtat ttgaacgatt cttgcgggaa gcctttgccc 3790381 acccggaaga aaccgatgac ctggcgacag atatggcttg gtatttatgg acaggcgaat 3790441 actcctccct cttcggaaaa cgcgccatga cgacatttga gcgctatttc atcaaagaga 3790501 aggaaacgca taaagagaag aaaaacccgt attattattt acgagaagac gaggcaacct 3790561 gccgaaacat cctggcagaa ttcggcctca atccagatca cggccatatc atcaacggcc 3790621 atacacctgt aaaagaaatc gaaggagaag acccaatcaa agcaaacgga aaaatgatcg 3790681 tcatcgacgg cggcttctcc aaagcctacc aatccacaac aggcatcgcc ggctacacgc 3790741 tgctatacaa ctcctacggc atgcagctcg tcgcccataa acacttcaat tccaaggcag 3790801 aagtcctaag caccggaacc gacgtcttaa cggtcaaacg attagtggac aaagagcttg 3790861 agcggaagaa agtgaaggaa acgaatgtgg gtgaggaatt gttgcaggaa gttgcgattt 3790921 tagagagttt gcgggagtat cggtatatga agtgaggggt gtggggttca gggatggtga 3790981 tatgctgctc ccctaaaagt agatagatga attttagaaa atctgtttgc cttggggagt 3791041 tttttcatgg ctggacaatt atactacaag gaagaaatac taatacttat agaatgtaat 3791101 tgggtaatga ttcggagaaa gaggttgcga aataatatgg tattacactg aaacaattat 3791161 caatggagaa catgcacgat atagccgttc tatattctcc ctctattatg gcactcatta 3791221 gtagacataa ccgtaaaaaa atgcactcaa aaaaagtcca ttctatataa ctctcgctag 3791281 ggtggacctt tttcaacatt caaagtacta gattttttct agtgaaagaa taagaaaaga 3791341 cataagttct attttatcac tctgttatag gttaagttat tacggtgttt cattatatac 3791401 tgaatttaaa cacccttgac attatgggaa tttttaaaac aggttaaaag gaagttctat 3791461 aagaactccc tagtttaata ttatttggtc aaaatctaaa accaaaaaat ctatttttat 3791521 cttcattgtt tctatctaat tttgcaacaa tcataccttt cgactctaat tcttgaaggt 3791581 catctaataa taattcattt ttatttattg ttacaaaata ttgtccgatc ctattctcta 3791641 acagacttga attgatatgt tttaataatg taccttttac atgaggatca ggattagaat 3791701 aagatccgtc atgaattaaa atattcaaac tacacttatt tatacacctg tataaaaacc 3791761 aagtaagatc aaatatattt atcttcatat ggagtctacc atgtgaacgt tcatccggta 3791821 tagaacaaga aattttgatc cttcctgtag ttgattgttt tgcgttactt attctattat 3791881 catattcaaa atctaaaaat ccatgttggt tgtatgtaac atccattaga ttattaaaaa 3791941 gcttctttaa ctcactaact atagcgctat aagattgaaa ctcatcataa tacattgaat 3792001 taactcttaa tatttcatgt tgaagttcat taatcttatc aaaaatatgg ttttttttat 3792061 cgtagtcact aattctcaat cttacttccg ctaactctat ttctttcctt ctttgttctt 3792121 ccatcacaat ggaaatatcc tcaatgaaat tgttactctt taaaattctg gcacttgatt 3792181 ccagttgttc tgttaatcct tgctttttga tattaagttt ttttaaatcg gcttgtattt 3792241 taacaatttt atctttaaaa taactccctc tactttctac catgaaatta tagaactctt 3792301 ggactttatt ataattctgt tttacttcct ctggaaaaaa acctacaata tcttcataga 3792361 atttttctat attttctaat tctttaatct tagttacttt tttatttaaa tcatctatat 3792421 ttctttgata ttgtttacaa atatgttcat tttcaaatat ttcattttgt attttattaa 3792481 gttcactttt aatttctgag tacctatttg tatcattatt atatttattg gcagtcttag 3792541 tttgatagat aactctattg taatcctcta tctcatttat taattcatct tccttaactt 3792601 ttaaatcgcc aatgttaata ttcattgatt caatcaattt tatttcacta tttaattttt 3792661 caatcttatc ccgaaaaacc tttatgtttt tttctgtatg agttggtaaa gtaaaaagat 3792721 agttaagtaa tttatattgt tttaaccctc ccctattcgg taaaactata tcattaaacc 3792781 ctgtcttttc gtctcttata atatactccc ttaacgccgc aaaagttata tcctctttct 3792841 caccctttaa aatttccttt tcaataaatt ttttatatac acttatacta acttttttcc 3792901 attcctccaa attaaaagtt aaagaagtat catgtaatgt ataaccatgt ttaggagaat 3792961 taaaagatct agcaaggaat acttgatttc catcaatttc cacattcaaa acaataaaaa 3793021 cgtttttatt gagaagaatt tcatttgtcg tataaaaatt tgatatagtc ttccctagta 3793081 aaaaggagat gcattcaatc atcgttgact tacctacacc attagtctct tcatgatctt 3793141 ctctcttttc accaagtatt atatttactc ctacagcatt aaatttatac tctttcaaaa 3793201 tttcttggga attgcaaaca aaaagatttt ttataatcat aacaatcact aactctccgt 3793261 tctgctaatc atattttgat taaaagaaac tttacctaat gaatataaaa aagttaacga 3793321 taaatacagt atccgttcaa tattcaaatt tattataata ccttgactct tagcataatc 3793381 aagaaaaagt tgatcaatat gtttttcctt ctctaacagt tcataaagta tctttgatga 3793441 gtataaaata ttttcttcca cagcattata tttagttaat aaaaaatgat tcatttctgg 3793501 cctctccgcc ttttcctttt ttaaaggaga attattcact agaggaataa gatcatttcc 3793561 aatttgaatg tttttaaact cattttctaa taaaacataa gagtatttga gaatattttc 3793621 agctgtttca attttaagat caatcattct taacacttct tttgttatca ttaaaaatct 3793681 cacattcata aatgcaccaa catgttaaaa tcttaatgta ttttttcgtt aaagcctttg 3793741 aatatggtaa aactgaatga cattctagat aaatctcatt aacaattttt acaaatatct 3793801 catctccatt attatattga ttatgaaact ctagatattt gtctactatc gtctcagcaa 3793861 tcaattcctt tttatcagca cttacatacg aagtggaatc cattatatgg tttatcacac 3793921 caaaatactc agaataacta tcgaatttcc gtttaaaagt ttccccactt ttcatatcat 3793981 aaaatttttt atctaaacca atttgattat caaaattact agtaaatgtt ttataacttt 3794041 ctctatactc atgaaaatct ataataaagc tcttaaactc atcttcatca attttatcat 3794101 cgttatcttc tatttctttt tcaataaggc tctctaatct attaatctta taatttaact 3794161 tcccttcctg tagtctcctt cctccttggt tgttttttga ccagtattta tattcggtat 3794221 tccaaatgta gtatgttact tctgtctcgc cattatctaa attcacatcc accgaaataa 3794281 attctggagt agcatactca tcctttataa tggctccact tactaattct aagaatggat 3794341 tttcatttgt atttgcagta atattaaatg aagaatcatg tacatgtcct gccaaatata 3794401 gatcaataaa gtaatcatca aaatgtgcct ttattgattc tctttcggaa gattcaatac 3794461 aacctaacgt atggtgccca atagctatat ttaatacctt gcccttattt ttctctttgt 3794521 tcatcttcct tattgcttta tataatttca tctgtgcagt taataacgtt ccttcttcac 3794581 cttttttatc tgataacaga catgtattta ttgataaaac attatacttc tccgattgat 3794641 acaaaaaatg caaatcttct tccggatatt taacacccat aaaatcttca taaaaatcga 3794701 aaaatttcct ttgaccttcc actaatatat ttgtagcttt ttgatctagt ttatccaaca 3794761 tttctgaggg gttaggagat ttcataatac tatcaatcaa aagtgtcctc gtcatgtctc 3794821 tagatatatc gtgatttcct ggcactaagt gtacgttatt cttacttaat cccatacttt 3794881 taataattcc attaagatat tctttaacat cttcgttata cacatcacct ttgtgtgcta 3794941 tatctccagt taataataaa aaatcaaaat ctgactctct tcttaaaact tctataaaat 3795001 ctaataattt atctctcatt acaatagtgt cataattttg aaactgaaaa tgcaaatcag 3795061 aaatttgtaa aaaacgtacc ttcaatacaa acatcctctc ataagtatat ttatccccta 3795121 tatatttcta gaaaactttt tattctatat catctttact ctttaatata ttaagactct 3795181 ttccacacca tcaaataaat tataacctaa acataactct ttactcattt tagtattgta 3795241 tttaagtcaa acattgcatt ggttgctgaa atattatatt cattgaatta ttccattaaa 3795301 tagcttttag ttgaacttta gtctttctgt aatggtggag atgctcttac ttatgataag 3795361 gctccccacg attaatccga aaagcccgat aaatctgctc cactaaaata agccgcatca 3795421 actgatgagg aaatgtcatc ttcgagaacg atagcttctc gtccgctcgc ttcatcaccg 3795481 tgtcactcaa tccgagtgat ccgccgatga cgaaggtgac tttgcttttt ccataagtag 3795541 ccagcttatc tattgtatcg gctagttctt cggatgtttt catttttcct tcgatggcga 3795601 gggcgatgac gtgggcgtcg gggctgattt tggataggat gcggtcgcct tctttgtctt 3795661 ttatgatttt catgtcctgg tcgcttaggt tttccggcgc tttttcgtcc gggagttcga 3795721 tgatgtcgat ttttgcgtag gccgaaagtc gtttggtgta ttcttcaatg ccttgcttga 3795781 ggtatttttc ttttagtttt ccgattgtca caatattgat attcacaggt catccccact 3795841 ttaaaaacaa gttattcata tatgttgtcc acaattgtgg atatcttttc tgtattttgt 3795901 gtaagatcat tcgttcccca ctatatatac tgcggggtct ccacataatt cacaggctgt 3795961 ggataaactg ttagtatgtt cgatttttct gatttcgggc ggcagctcgt ggtcgtctat 3796021 gtacatatcc agcaccgttt cgatgtgttc ttcacaagaa taatacgctt gtttcatgtt 3796081 caaatcctcc gatgttttct tccattttta caaatgttct cttctcaata taacctattt 3796141 attcacatgt tagtagtgct tcgggctgag ttttatccac aattcgacaa acaagctgtt 3796201 gatgactcta tttcgctcgt gtgttagttt ggatgtaacc gatgtgtggg gaggtctgca 3796261 tttgcgcttt agatgggttt ggctttttgt gattatgttg ctgcttgctg agtgtcagcc 3796321 atcttattgg gtgttggaga aggatcgaat cggtgaaggc agtccagact tagaaatata 3796381 cgctaattat ctccaaatgc atgatgacgt gaaaggatat caagtcttca ccatatcaga 3796441 aggcaaaaaa atggtcgtcg tgtctctcgg aagcagcgag aaagataaga agcttgaagt 3796501 gtcggacgtc aaattctcat ctaaagaaac gattgtaact gtggagcgaa aacctgctcc 3796561 tacggcaaat gagaaaaacc cttttatttt gattggactg gacaaaattg aaggggattt 3796621 aattgttcaa gacgaaacag gagatcgctt tgaagaaacg gattaccagc aataaagccg 3796681 gcgttctgag aacgtccggc tttttctttt acttcaatgt cccatgcggg tcgatgacga 3796741 attttttggc tgcgcctttg tcgaagtcgc tgtagccttt tggcgcgtcg tccagagaaa 3796801 taacggtggc attgacggct tttgcgatct gcgctctgcc gctcaggatc gctttcatca 3796861 aattgcggtt gtatgtcatg gcgggcgttt gtccggtgac gaaggtgtgg gctttggccc 3796921 agccgagtcc gaagcggatt tttaatgagc ctgttttggc gtccgcatcc tttgcaccgg 3796981 gatcttcggt cacgtataag cctggaatgc caaggctgcc tccgacctgg gtgacgtcca 3797041 tgattgagtt cagcacggcg gctggcgctt ctccttgatt gccgtgccca gatgcttcaa 3797101 agccgacaca gtccactgca gcatcaacgg ttggttcacc tagtatttgt tcaatttgct 3797161 cgccgaggcg gtcgtgtttt tgcacgttga ccgtttcaca gccgaagctt ctggcctgtg 3797221 ccagcctgtc ttcgttcaga tcgccgacaa tcacggtaga ggcgcctagg agctgagcgg 3797281 agtgtgcagc tgccaagccg acaggacccg ctccagcgat ataaacggtt gaacctgttt 3797341 gcacgcccgc tgtataagct ccatggaagc cggtcggaaa aatgtcggac agcatggtca 3797401 aatcgagaat cttttctagc gcctgttctt tatcagggaa taccaaaagc tgaaaatcag 3797461 cgtatggcac catgacatat tcagactggc cgccgaccca gccgcccata tcgacgtagc 3797521 cgtaagccga tcccggccgg tccggattga cattcaggca cacatgcgtt ttctgcgttt 3797581 tgcacatcac acagcgtccg caggcaatat tgaaaggaac ggatacgata tctccttttt 3797641 tgataaattc aacatcacgc cccgtttcaa tgacttctcc cgtaatttca tgcccgagca 3797701 ccaagccttc tggcgccgtt gtgcggcctc tgaccatatg ctggtcgctt ccgcaaatgt 3797761 tggttgtaat gactttgaga ataaccccat gctcacattt tcgattcaca ttcgccttcg 3797821 ggacgccggg cccgtccctc aagattaact ccggataacc gatatcctcc accgctacag 3797881 tccctttgcc tttgtacaca accgctttgt ttcctgtcaa cgccattcct cccattcatg 3797941 tgtttggact ctccgtcctt gaacatgact tcggttcggc atgactcttt ccctttttca 3798001 cgactgtttt ttctgtattc ttacaacaac aaatatgcca agaaagcatc caataatggt 3798061 tccgccgatg tctaagaagt cgactttaca tccatttaac aagaacacag taatggccga 3798121 aaccaggcag atcataactg ccagaagaat aacccgattt gtctgcatgt aattcctcct 3798181 ttggattcgt ttctaaacca tacccaaaat cctctgcaaa cttcggttca acaaaaaaag 3798241 agacttcaca ccagtctctt cataaacaga gatcactcaa aaaatttcct gagaaataat 3798301 gtggcaacac tcgttactaa cgcaattgcc gtatacataa caacccaaaa tatgaatgag 3798361 ctattccccg aagctaacgt aactaacaat atcaagctcg tgataagaac gatgagcggt 3798421 gccacccaaa atcttttaaa taaaaaatga cccgctatac caaatacacc tgcgacgatc 3798481 ggaaaaccaa aaacgataaa taaaacggcg atggctccca tactaccctc cttgccttaa 3798541 aacctcttca tcacctcaac atcatacagc ttcaaatgac tcttcggcgt cacgacatcc 3798601 tttaccttcc caatctcttt ttctttcatt ttctttccgg ttttcaggct gtactgttca 3798661 atgtaggcag gcttgtgata cgtgtatgtg aagaaataga ggctgctgcc tttttgggtg 3798721 atttctttga attcggcttt cattttgtcc ggggaaaggg tgaagacgat gcttgttttt 3798781 cctgtcttgg catcgatttt gtgtaccttt ccgaagccgt caatgaaata caggttcccg 3798841 tcataaggga aaaagctgtt tttaaagctg aagggcatgg agctgtatat cgtttgttcg 3798901 tcgtttttgt attcggcgat atcgtgcagc tctacttcgc cgcttttttt gttgatcttg 3798961 accatttgat agagatcgtg ggctttttgg ccgcgaacca taacatacac agcttggtcg 3799021 tccacggcaa gttgggattc gactgaggct ccttcccggt actgccattc cgttatgctg 3799081 agataggtaa gcttcttctg atctgcttga atctgaagga gctgatagcc ttttccgtca 3799141 tctgtcggga cgagtgcgta aatggcgcca tcatggaaac cggaggctcg gatgtagtag 3799201 gggatgacgt cttttttcca ctctccgtcc atttggcggt acagctctga gcggtatccg 3799261 tctccctttt tgtcgtagcc ggagttgtat aaggtgtaaa agccgtccgt gttttgcaga 3799321 aagcccgcgc tgtcgcctgt gtgctgatag gttcttttat gggagcgcag gccgtttttg 3799381 atcgtataaa tcgtgttttt gtcctccagc atcacgctgt caccgtgaac ctttgctgag 3799441 cccagctcaa ggcccttcat ctgaaaggaa gacagcgtcc cgtcatggct gataaacagg 3799501 gcgtagcttt tcccgccgcc aaatgcatct tgatccgcag aggatgagaa atacagcagg 3799561 acttctttgt catccaggaa atcgggattt ctgagatcct gctgactcac ggttttatgg 3799621 cttttgagag gagaaatgaa gacaaatagt gcgattcctg cgagaatcag catggcgatg 3799681 gtaatcatcc actttttcat agccttctcc ttagtaaatg gtcataatgg ttgtcgtata 3799741 agaagaacta gtgatgtcgc gcggatacac gcctaagcct ccgttgctgt ctatatcaat 3799801 ccctgctttc agcaaaaagg cagaccatag gagctttgaa cagtttttgg cgccgtcatg 3799861 gccggtattt ctgttattga cgaagttaaa tgagtatggg tcgccgactt ttgataccgc 3799921 ccagtcggca gcagctgttt tttgagatga ggatacgctg acggtttgca caatggagtt 3799981 gtcttccacg tctctggcat tatacgcgat ctgcctgacg ccgtcgctcg ggacagattc 3800041 aacaattttg tcagcggcgg agtacatgcc gacatggccg tgattgtagt aggctgtgta 3800101 ggagttcgtg taatagatat tgcctttcgc gcttgtcggg agttttttcg tgccggacga 3800161 gccgcccatg atagacatgc cgctttcctt ggcgagccgg tccccctctg ctttatcagc 3800221 cgtgatctcc ttatagaact gttttaggat aacgtcctgc tttacgtgct gctgtttggc 3800281 aatctggctg gcagatttca tgatttcttc cggtgtcgtg cctggctgca gtgcggcgat 3800341 ttcttcagca taatttgtgg tctttacggc tttggcggga gtaacaaaca ggccgccgca 3800401 cattgtgagc gctaccaaaa acatcgacac tcgtttcttc aacttcatta catctcctct 3800461 tttcttgtga gtgtaggaaa ggtaatttcc tcacccacat tatattagga aaataaggaa 3800521 agtaactagg ttatttacag aatttttaga aatcgtttac agaaaaaggc ctttatcagg 3800581 cccttttcgt taaagcttct tgctcatcac tacgtctgtt tcttgaaatc cggtttgctc 3800641 atatagcttt cgagccgtct gattatgggc aaagacatga agggacagct tgcggattcc 3800701 catactgcgt gccgcttgat ctaatgccgc caatgcttgc tttgcgtagc cctttccccg 3800761 atacggttca tataacccga aatcataaat aaacgcttcc tgctgcggat gctccggttc 3800821 agcatgtatc cagagccagc caacgatatc cttttcattc agcttgaggc tccacaaatg 3800881 gtgatggggt gtttcgagcc ctctcggaag cagatcagta aacacctgct tagacaaaag 3800941 ctgggcatct tcaggcagcc atgttcccgc ttttaccttt tcttccgcgt aatgctttgt 3801001 tgtgtacgtg agataagacc gaaattcttc tgtctgcata ggggttagca taattgtcat 3801061 atcatctctc cttcatatat tgactagagg attttacata aaatagaaag aggtgttact 3801121 atcagaataa gcaactgaga ttgataagtc actagagaaa ggagtttcac atgaataaga 3801181 tcgcacccgc agaaatcgct agcatgctca acgattggta ccttgccatc aagaaacatg 3801241 aagttgaaga atcctcccgt ttatttgaag aagtgaagcc tttattggat gacatggaag 3801301 aggatcagga ggtgcttgcc tacttctcct tattggaact gcgccacaag gttttgcttc 3801361 acgaggcgag aggacagggc tttcagcatg aggagccttc tcatatgaat gctacgtctg 3801421 acatgctgaa atattacttt tttctgtttg aaggcatgta tgaggcctat aaaaataatt 3801481 atgacattgc cattgggctg tataaagatg cagagcagta tctcgacaac attcccgatc 3801541 cgattgaaaa agccgaattt cacctgaagg tcggtaagct ctattataag ctgggacaaa 3801601 atattgtgtc cctcaatcat acacggcaag cagtcaaaac attcagagaa gagacagatt 3801661 ataaaaagaa gctggcttca gccctgatta ccatgtcagg caattttaca gagatgagcc 3801721 agtttgaaga agctgaggct tatttggacg aagcaattcg gatcacgagt gaattagagg 3801781 atcatttttt tgaagcccag cttttgcata acttcggcct tctacatgcg caaagcggca 3801841 aatcagaaga agcggtttcg aaattagagg aggctctaca gaacgatgag tatgcccgct 3801901 ccgcctatta ttatcattct gcctacttgc tgatacgaga gctgtttaag atcaaaaaga 3801961 aagaacaggc cttatcttat taccaagacg tgaaggaaaa attgactgct gagccgaata 3802021 gaatatgtga ggcaaaaata gacattttat atgccattta tgcagaaggg ggtcatgcgg 3802081 aaacgtttca cttatgcaaa caacatatgg atgacttgtt gtccgagaaa gagtatgaca 3802141 gtgtaagaga actttccatt ttggctggcg aacggtatag ggaacttgag ctttacaaag 3802201 aagctgccca ctttttttat gaagcattac agattgaaga actgattaaa cgaacggagg 3802261 ttatataaat gaaaagattt ctgattggcg caggcgtcgc agcggtgatt ttatcaggtt 3802321 ggtttattgc ggaccatcaa acccactcac aggaaatgaa agtcgctgag aaaatgattg 3802381 gataaatgaa aaacccccgc gggatgcggg ggttcaattt aacgaaagaa tcctaaaacg 3802441 gtttgtagtt ttaggattct ttcatctttt cagcgtgatt gaaaaccctt gaagtctagg 3802501 aagaacgagc attggagcgc agcgaatgtt tggaattcgt gagcaccgaa gcgcaggcct 3802561 gacaacgaat gcgagggttt gtcgacacgc tgaaaccccc gcgggtgcgg gggttttctt 3802621 attacagcag cttcttccct aacagggatt ctacgagctc tactgctgtt ttgcccgttt 3802681 tgtttttgtg atcaaggatc gggttaacct caacgaattc ggctgaggta atgatgcctg 3802741 cgtcatacag catttccata gccaaatggc tctcccggta gctgatgccg ccgacgacag 3802801 gggttccgac acccggtgcg tcgttcggat caagtccgtc cagatcaagg ctcagatgga 3802861 cgccatcaca tgctgataaa taatcaaggg tttcttcaat gacctttgtc atgccaagac 3802921 gatcgatttc gtgcattgtg tacaccttca tgccgctttc cttaatgtac ttgcgctccc 3802981 cttcatcaag tgaccgggcg ccaatgatga cgacgttttc cggtttgatt ttaggcgcgt 3803041 agccttcaag gttaaccagt gactcgtggc caatgcctag gctgaccgcg agcggcatgc 3803101 cgtgaatatt gcccgatggt gaagtttcaa gtgtattcaa atcgccgtgc gcgtcatacc 3803161 agatgacgcc gagattatcg taatgcttcg ctgtgcctgc aagcgtgccg atcgcaatac 3803221 tgtggtcacc gcccaggaca agcgggaatt ttttctcttc aatgactttg ttgacctttt 3803281 gcgcgagttt ttcatttccc gccaaaacgg aattcaggtt tttcagttcc tcgtcatttt 3803341 tgattttttc gcgattgatc ggaatgtcac cgagatcttc aaccgtatac cccatgtctg 3803401 acagcctctc gatcagatga gcgtaccgga tggcactcgg gcccatatcc actccgcgtc 3803461 gtgcttgtcc taaatccatt ggcattccaa taaccgaaat cgttttatcc atctgtgatt 3803521 ccacctcaac atttaagata atgtcctatg cgggttataa caaagatgac ttgcggacaa 3803581 cgtttttaaa gctctagctg acgatttgcc tgctggcgtt ttttaatgac gacatgataa 3803641 atgatgtagc aaatgatcat aaacggtacg ccgcaataca gcgcgatacg ctgctccgga 3803701 tcaaatgcaa gactgatgag cacgaccgta tttaacgtta ggccgatcag cggaagcacc 3803761 gggtacagcg gtgttttaaa tttcaaatct tctatcttcc cgccctcacg gatatatttg 3803821 cgtctgaaca tgatttggga aagcgagatc gtaatccagc cgacctgcgc gctcatgccc 3803881 gccaaagata acagtaccat atatacggtt tcagcctgcg caaactttgt cagaagtgat 3803941 aggcaggcca cagccatcgt tacgattaac gagtacatcg gtacaccgcg ctgatttgtt 3804001 ttgccaagcg ctttgaaggc ttgtccttca ttcgccatcg cgtacagaat acgtgttgat 3804061 gcgtataaac ctgagttcgc aacagataac agtgcgatta aaataacaaa gttcatgata 3804121 tcagctgcat atgggattcc gatttgctca aatacggcaa caaatggact ttccacgaca 3804181 cccgcctgtt tccacggaat catgccggca atgacaatga ttgaaagcac aaagaacaca 3804241 agcgttctcc atactgtctg tttgatggac cgcggaatcg ttttttcagg gtcttcactt 3804301 tctccggctg caaccccgat cagctcagtc ccctgaaacg caaagttcac agtaatcatc 3804361 gtaatcagca ttgcctttat gccgttcgga aataacccgt cttcataaaa atgtgtcaaa 3804421 aacggcgcct gctctccgcc cttcagatca atcaggccaa acatggcagc tccgccgaga 3804481 ataataaata aaaggataat caaaatttta atgcctgaga accagaattc agattccgca 3804541 aaggcttttg tggtgatcgc atttaaaata aacatcagtg ccgcaaagac cagacaccag 3804601 atccacacgt ctatatgcgg aaaccagcgt tgcatcagct gccccgctga taaaaattca 3804661 atggcgcatg taaccgccca gccgagccag tacagccagc cgaacgcaaa cccgaaggcc 3804721 gggctgataa atttcgtggc ataggtctgg aaggaccccg acacaggaaa ggcgactgcc 3804781 agctctccta agcagagcat ggtcaaaaac atgataaagc cgcccactaa ataggacaga 3804841 accgcgccga gcggtcccgc ttggttaatg gtaaacccgg ttccaaggaa gaaaccggtt 3804901 ccgatcactc cgcccaatga aatcatgaac aaatggcgtg atttcattgt ccgctggagc 3804961 tgatttccgt tatcttggtt tgtattcaca ttctgcaccc cttcagcaac ttgtattgga 3805021 tctaagctgg aacatctgca tggtgctatc ccagtttgct gtccaaagag tctctatcta 3805081 tttaatataa aattcacttc ttctcataaa gatacattat actaaaatac tgtagctgag 3805141 caaataggga gtgctgattt ttctgttgta aatttataca aacgaagtga atatcccgcc 3805201 atggtgcgga tttatgcgtt tcgcagcacg tgcttaattt tctctatcgc ccaatccaag 3805261 tcctctttgg aaatgattaa tggcggtgca aaacgaatga ctgtatcatg cgtttccttg 3805321 cataaaagtc cctcttcctt caaacgctca caatacggac gtgccgcttc agtcaattcc 3805381 acaccgataa acagccctct gccgcggact tctttaatga cagggctgtc aatactctca 3805441 agctcgcttt taaagtattc accaagttca agagaacgat ccgccagctt ttcatcctcc 3805501 agcacttcta atgaagcgat agacactgca catgcaagcg ggtttccacc aaatgttgag 3805561 ccgtgtgagc cagggttaaa cacgcctagg atctcgcggt ccgccgcaat gcaagagatc 3805621 gggaacacac cgccgccaag cgctttgccc aagatataca tatccggaac aatgccgtcc 3805681 cagtcacagg caaacgtctt gcctgtacgt ccgagacccg tctgaatttc atccgcaata 3805741 aacaagacat tctcttcctt acaaatcgcc gccgcttcct gtaaaaatcc ttcaggcgga 3805801 atcacaatgc ccgcttcgcc ttgaatcggt tcaaacaaga atgccgctgt attcggcgta 3805861 atggcctgtc gaagcgcttc cacatcgccg taaggaatga gtttgattcc tggaagcatc 3805921 gggccgaatc ctcgtttata ttcctcttca gaagaaagag ataccgccag catcgtgcgg 3805981 ccgtggaagt tcccgacaca tgcgataatt tccgcttgat tgtcagctac gcccttcact 3806041 tcatacgccc agcgtctcgc cgctttcacc gcggattcaa ccgcttcggc tcctgtattc 3806101 atcggcagaa tcatctcttt gcctgtcagt ttagctgttt tttcgtaaaa cggcccaagc 3806161 tgatcgttat gaaacgcgcg tgacgtgagg gtgattttat cagcctgatc ctttaatgcc 3806221 tgaatgattt tcgggtgtct gtgcccctgg tttaccgcag agtaagcact cagcatatcc 3806281 atatattcat tgccttccgg gtcctttacc caagcaccca gcgcttcaga aataacaatc 3806341 gggagcgggt gataattgtt ggctccgtaa tgagacgtct gatcaataat ttctttggat 3806401 ttagataaag ctgtcatatt tgaattcccc cttgttttct gtttcaacat gttatcctgc 3806461 tttcccttta tataaatgca agttctgtgc caaatcaaga attcgtgtgt tttctacaat 3806521 tttcgaggac aaggtgcaaa aacattctga tatttcgagc gaaaatttca gcaagtgcaa 3806581 aattcttttg catatcctct ccgttttttt ataaaataga agcaatatta agaaaataat 3806641 tgagggaggt tcatacagtg gtcaaagaca gcgaattcct cacattggtt tttcagagta 3806701 ttttagatga aatcgatgtt ggcctgcacg tggtagacga gcatggaaac acaatcgttt 3806761 ataacaataa aatgatgcag attgaagata tggagaagca tgacgtcttg aataaaaacc 3806821 tgatggatgt gtttatgttt tcaaagcagc aggacagcac actggtacag gctcttcagg 3806881 aaggcaagac gattaaaaac gtcaaacaga gctatttcaa taataaaggc caggaaatta 3806941 cgacgatcaa tcatacatat cccatcgtcc aagacggcaa aatcaggggc gccgttgaaa 3807001 ttgccaagga tgtgacaaag ctggaacggc tgatcaggga gaatatgaac aaaaaaggca 3807061 gcacaaccta tacgtttgac agtattctcg gcaccagtcc ggccattcaa gacgtcatcg 3807121 aaaacgccaa gcgggcaacc cgtacgtcat catctgtcct tctagcaggc gaaaccggca 3807181 cgggaaaaga actgttcgcg caaagtatcc ataatggaag cgatcgttct ggcggcccgt 3807241 ttatttcgca aaactgcgcg gcactgccag acagccttgt ggaaagcatt ttgtttggga 3807301 cgaaaaaagg cgcgtttacc ggcgctgtcg accagcccgg cctgtttgaa caagcccacg 3807361 gcggcacact gctgttagat gaaatcaact cgctgaatct cagccttcag gcgaagctgc 3807421 tgcgcgccct tcaagaacgg aaaatcaggc gcatcggttc aacaaaggat acaccgattg 3807481 acgtacgtat tattgccacg atgaatgaag acccaattga tgcaattgca ggcgaacgaa 3807541 tgcggaagga cttgtattac aggctgagtg tcgtcacact gatcatcccg ccgcttcggg 3807601 aacgaaaaga agacattttg cttctcgcgt cggagttcat ccagaaaaac aaccatctgt 3807661 tccaaatgaa tgttgaacac atcagcgatg acgtgaagca atttttcctt tcttatgact 3807721 ggccgggaaa tattcgcgag cttgagcata tgatcgaagg cgcaatgaat ttcatgacgg 3807781 acgagcaaac gattacggct tcccatctgc cctatcaata ccgcatgaaa atcaagccgg 3807841 ctgacatccc agagccggaa acaccaagac accagccagc cgcggactta aaagaaaaaa 3807901 tggaaagctt cgaaaaatat gtgatagaga acgtgttaag aaaacacggc cataacatct 3807961 cgaaagctgc tcaggagctt ggcatcagca gacaaagcct ccaatatcgg ctgaagaaat 3808021 tttctcactc gtctaacgaa taatccggag caggaagcct gatcagaaaa acagtgcctc 3808081 tgccgatttc acttttcact tcaatcgtcc cattgtgatt gtcgataatc gatttcgtta 3808141 tggcaaggcc taatcccgaa cctccatatt tccgggagcg ggatgggtct gccttgtaaa 3808201 accggtcaaa cactaaaaaa cgtcacttct tatgcattga agaaagaaaa tggcacctat 3808261 gtgtatcaca gccagcaacc acacggtaca aaccattaaa gtccatgcaa ataacggaag 3808321 tatttgcagc taactgccat ttgctgtttc acgtgtaaca tccatcttgt atttttcttc 3808381 atattcgata tatccttttt caactgaacg ggcgtgaccc ctgttcagtt ttttttgcat 3808441 atcaaaacag cctggcaacg atgccagact gcttttatta actgcctaat tggtctgcgg 3808501 aggacagctt gatatcaaca gatttttctt ttccgccgcg ataaaacttc accttcaccc 3808561 ggtcaccgac ttttttctga taaagccgtt ttcgcaggtc aacaatatca tttactttgt 3808621 atccgtcaaa ttccgtgatg acatccagtt ccttcagccc cgcttttccg gcaggtgaaa 3808681 aggcgtctac acccatcaca accgctccat tggtgacgtt cttaggaagc tttaatgttt 3808741 catcccaatg atagcttgcg atgtcactta gcgatttcat ctcaatgcca aggaacgggc 3808801 gtttgacctt tccgtatctc tctaaatcct ctatcacagg gatcacgagc ttagacggaa 3808861 tggacaggcc aatcccttca accgctgact cggcaatttt cattgaattg atgccaatga 3808921 ccttcccatc catatttaac aaagcgccgc cgctgttccc agggttaatg gccgcatctg 3808981 tttgcaggac ttcagcgttc cagtcaggct gtccatcacc gtttgaatct actgggatcg 3809041 ccctctccgt acccgagatg acgccttgtg tgacagagcc tgcaaactca aggcctaacg 3809101 ggttcccgat cgcaataacc ggctccccag acttcacttt atctgaattt ccgaaatcag 3809161 cgactgcttt aatcttatcg cttttcaccc gtaaaacggc aaggtccatc agctggtcgc 3809221 tgccgacaag atcagctgat acacgtgagc cgtctttcaa gctgatttca atttgggaag 3809281 cgccttcgat gacatgatgg ttggtcacga cataagcgga atggtcattt ttcttataga 3809341 tgacgccaga gccgctccca gcctcgccgc tctctcccca aatatctgat ttttggatgt 3809401 tcacaacacc gacaacggcg ggcgacatat tgctgacaat cttggtgacg gcattgttga 3809461 cactgacatt caccgtcctg attgattccc ggccattgtt gttttgctgc tgatctaagg 3809521 cgcctgtatc cagcccttca tttgaaaggt acggcatgat aaacgccatt aatacggcac 3809581 cgacaatcac gccaatcaga ctcgaaagaa aatatccttt tttgcttctc tttggctgtt 3809641 caggagtagt atgttcttcc tcacgttcgt aatccaccat attccatcct ttccaagaac 3809701 gttaatatgg ttatattgtg ggttagaaac tcctagaata gtcatgattt acatagaaaa 3809761 attatacagc gcaaagcgga gtggccttct tcggatcggt gtcgtataag tcaaatgtct 3809821 cacccgtcac aaatccttta gaagccaatg tctgctgcac agacattctt gccagctcct 3809881 tcatgttgtt gtcctggctc aaatgcgcca ggtaaatacg agacgtctca tcgccaatga 3809941 catccgtcat cgccaaggca gcatcttcat ttgacacgtg cccgacgtca cttaaaatcc 3810001 gccgcttaat gctccatggg tatcttccca tttgcagcat accgacatcg tgattgcttt 3810061 caaacacaaa tacattcgct gaacggataa tgcctttcat ccggtcgctg acatatcccg 3810121 tatctgtcat taacgcgagc tttcggccgc tataatggaa tacataaaac atcggttccg 3810181 ccgcatcgtg ggaaacgcca aacgattcaa catcaagtcc gccgaacgac ttcaccgtct 3810241 ccattggaaa tacaaacttt tgatcggtgt caattttgcc gatttgattc tccatcgctt 3810301 tccaagtctt ctcattcgca tagatcggaa gcttgtactt tctggcgacg acaccaaggc 3810361 ccttaatatg gtcactatgc tcatgcgtca caaaaatgcc gtctacatca tccagcttac 3810421 gcccgatctg cgccatcagc ccatccatgg cttttccgct caaaccggcg tccactaaaa 3810481 atgcgtgatc ctctgtttcg aggtaaaacg catttcccgt actcccgctc gcaagtacgc 3810541 taaattgcaa gctcatgttt gtctcactcc attattttca ttgatctgta tctaaaatcg 3810601 tactctccaa agcattcaca gtaaaatact cttgtactgt ctttttctca ccgttcactt 3810661 ttttctcgta ctcgaccgta attctccata ccggcgccag cacctgcgta cttgtcagcg 3810721 gatattgtgc tacatagccg aatttacagc tcttcacagt gctgtattct tttaattgat 3810781 tttgatagta caatagctca accgcatcca tttcagtaat taagctttct ttctggattt 3810841 gcttgaaggt ctcaagcgta gtctggtcgt atgacacaac ctcgttttta ccgtttaagt 3810901 gcagcaccac ttgcccgatc atattagagg gattgtcggt cttttggtaa atataatgac 3810961 cttcgtacgt ttggaagaaa ataatttctt tcttcgattt atcaaccttc caaagcttat 3811021 atttttcgcc atcttgaatt ttcgaagaaa caagtgcctg agcatcgtcc tcgatatcct 3811081 tctttgatag tgcgattgga tttgcaaact tcattttcag gctcgttact ttatgatcat 3811141 cactaggcat gtccatcaaa ggcttttgat ccttcagcgc ctcaatttcc tccttggaga 3811201 aagacttttg atttgccgtg atccgatagc cttctgttgc ttccttattc aagccttcat 3811261 acgtgatatg atcggccttc atgtcatgct cgacatcatt tttaatgact tcatattctt 3811321 tgccggtagc ctgccatttt tgaaaaaact gatagcctaa gaaaatatct aaaatgagga 3811381 aggcaacgat gaagattgat tttgtcttat tccactccac tgttagcccc ctccttcctc 3811441 aataaatcct ttgtaatcgg cacaattttt ccatttactt tcatcgccca aaccggttcc 3811501 agttcaacga gaggatcatc gttggttgat gttgatacca attgataagc aaggaagatc 3811561 tgatcaattt tgtccgtatc ataagcggtt tgtttcgaaa gcagcatctt cacttcgctg 3811621 ccgcccatga gctctgtttc acttgtttta atcggattcg ttccgagact gtaattcggc 3811681 cgcttatagc tgagaatatc atcattcgcc cattgcaccg taatcgccga tgtcgccccg 3811741 aaaggtttgg cggtgctgtt aatgaccggg atctgatcca taaaaatata gaagctcaac 3811801 tgctggctgt cattgatatt gaaaaattga tagtgatccg tccagcttcc ggtatcctca 3811861 aggtattttt ggctcttttt gattaattca cctgtttgat aggatgtgct ctgcaccaaa 3811921 ttgcgctgct gaaattgcac ctgtctctgg cttagattca catctaaccg gctgatccca 3811981 tctgtcagca catttctgtt ggtgtaattc gaatcttctc ttacaatgct cggatcacta 3812041 aacaaagcct gcttaaaggt atttgtttta atcgattctg tgacaaattc ttttttgtcc 3812101 atcgtaagcg gtttgttcgg cagcaagaac tctttctttg agccaatgga gaacaaactg 3812161 aacgccggca tatttgattg cctgtttttc aagtcgttca taatgttccg gtagtttgct 3812221 gattcaaccg tcacttcaag aatgagctgc ttgctgtatg acaccaaata gattttcttg 3812281 ttcgcttttg tttcattgaa cgggatcaga atatggtcaa acgaactgta ttcaaacgac 3812341 tgattagacc atttaaacag cgtttggaaa atatcaatcg ggatcgtatc gctgaattgc 3812401 aagtcaagct tggcttcaga accgcctatt ccataaaacc agcttttgaa tccagccttg 3812461 tcatactgat ccgaaatatc tttaattcct ttcacatccc aatgcggcaa gtcagaccaa 3812521 atttcttcat agagggcatt gtcatccact ttgtaatgag cgccgtcatc atggataaac 3812581 atgtcccttg gccttaccgt ttcagacagc ttttgggtgg ttttttcgat tttatgtttc 3812641 acacgaacag tagactctgt tgaggatgag ccttcagaaa agtttggctg gaacgtccat 3812701 atcccccatg taaaaacaag actgatgacg acgagtaccg taagtaatat cgtttttata 3812761 ttttcacgct tcatcccaat catcctcttg ttcctcttta tatggaagag taaatgtaat 3812821 cgtcgtgcct tttccttcta tgctgtccgc ccaaatatct ccaccgtgcg cctgtaccat 3812881 ttccttggca atcgccaatc ccagaccggt gccgccaagc tttctcgttc tcgctttatc 3812941 caccctgtag aagcggtcaa agactttttc gacatctttt ttcggaatgc cgatcccttc 3813001 atccttcacg ctgatataga gaagttcttc ctcttcattg acatcaatcg agaacgtgac 3813061 atgtccgcct tccggtgaat attttaaagc gttagaaata atattatcga gcacctgcgt 3813121 tattttatcc tggtcaatct cgacatacag atctctgtcc ggcagattgc ggataaactc 3813181 cacatgctgc tcttttgtca tttcaaaacg gtcaataata agtgacataa accggacaat 3813241 ctgaatccat tcccggttaa attgataatc tttactgtca aatttcgaca gctgaagcag 3813301 atcattgaca agccggatca tacgctctgt ttcattttgc gtcaccatta agaagcgcgg 3813361 agcaatgtct ttattttccc acgcgccttc agctaacgct tctaaatagc tgcgcattgt 3813421 cgtaagcggc gtccgcagct catgtgatac attcgcaacg aattctctgc gttcctgatc 3813481 cattttctct tgttcggtta catcgtaaat gacagcgatt aaaccatcaa ttttgccgtg 3813541 ttccctttga atcacagaga aattcacgcg aagcaccgtt aattcatcat cgcgctcaat 3813601 ttcaagcagc atagaatcct gctgttccac taaatcttca aaagtataat tctcttgaag 3813661 ccccagcaaa ctcgtaatcg gcatttctaa ggctgtttca cgtgaaacgt tcaacagttc 3813721 cagcgccggg ctgtttaaga gaataatcgc tccgtttcgg tttgtggcga taacgccgtc 3813781 tgtcatataa gcaatgacag aggctagctt tctgcgttct ccttcagtca tcgcctgggc 3813841 atcttcaagc tctctcgtta agtggttaaa cgttgtggcc agctgcccaa tttcatcatg 3813901 tccatacttt ttaaccttcc tcgagaaatt ccctttcgca agctccatcg cctgctttcg 3813961 catatctgaa agcgggtggg taatggttct tgccagaaaa ataccgagaa gagccgtcaa 3814021 aacaagtgcc aaacctgtgc cggacgccag tatcgtgttg atcgtcttca tttgattaaa 3814081 gacatcttcc atactcgcga caacgtagat cgcgcccaca acctcttggt tttcagtcat 3814141 gacgggcttc gcggaaataa gaactctgat tttgcttttc gggtcataat attttcttaa 3814201 atacgactgt ttggtagaaa agattctttt gaaaatcaga tcggtcgttt gtttcccagc 3814261 cacttcctca ccgtacggct ttgaagaacc gaccacttca tagcttttat ctacaaagct 3814321 aatttcccga acctcatcac ttttcgtgaa gtcattcaaa atacggctga cgtcatcctt 3814381 tatgacggta ctgtcgttat cgctcttata ttcttgttcg atataataag aaaggttgtc 3814441 gattcgctga ttcagcgatt gttcataaga gctgatcagc gacttctcta cctgattgac 3814501 aaaatacaca ccaatgattt gcatggcaat gataatcaaa agcacataaa tcaaggtaat 3814561 cttaaattgg atcgaccgaa aaaaaccaac cttattcata tgggcattag tcctgttctg 3814621 ggtttctcaa gtaataacct acaccacggc gtgtgacgat ccaatttgga tggctcgggt 3814681 tgtcctcgat tttttcacga agccggcgga ctgttacgtc aaccgttctg acatcgccga 3814741 agtaatcata gccccaaacg gtttgaagca aatgttcacg ggtcatcact tgtccgatat 3814801 gttttgctaa ataatgaagc aattcgaact cacgatgagt caattcgatt gtttcgtctc 3814861 gttttgatac aacgtacgcg tcagggaaga tgacgagaga gccgatatga atctcgttag 3814921 aggaaggctc ttcctccgca ggcgctgttg tcagctggcg gcgcaggttc gcttttacac 3814981 gcgccaagag ctcgcgtgtg ctgaatggtt ttgtgacata gtcatcagca ccgatttcaa 3815041 gcccgataac cttgtcaatt tctgaatcct tagccgtcag cataatgatt ggcatatcgt 3815101 atttctttct gacttcgcgg catacttcaa cgccgtcttt atttgggagc ataatatcta 3815161 aaagaattaa atcaggctga agctcttcta ccatttcaac ggcttcgttt ccgtcgtggg 3815221 cacagtgcac ttcatagcct tcttttctta agttaaattc caatatatct gcaatcggtt 3815281 tttcatcatc tactacaagg atctttttat ccatcatttt gattttcctc ctgccgaatg 3815341 acttcatttc atctatataa cattcgtttc atcacttatg gcccatgtaa agaatgggtc 3815401 cttgtctatt ataacggttt aaggtcaaaa gataaaaaaa ataaaggttt agaaaaaaaa 3815461 cacatgtttc acctttatcg ccagttgttt atctattgtc atgctggtca acttttttta 3815521 aaaaagataa ctttattgaa acctcccctc accggagtgc gtctttatca atgacgtctt 3815581 cttctttgaa ccggccgcag ggccggttct ccctttttct tctattataa cactcctcat 3815641 gtttgccttt ttcctaaaag aaaaaacgca cctacgattg cagatgcgtt tggtaagtgg 3815701 ctcgggacgg aatcgaaccg ccgacacacg gattttcagt ccgttgctct accaactgag 3815761 ctaccgagcc aaatgtttta tttttctcta ctaagtaaag taaaatggcg gtccggacgg 3815821 gactcgaacc cgcgacctcc tgcgtgacag gcaggcattc taaccaactg aactaccgga 3815881 ccttacagta attgcccgga gagctgtcgt gtcagctctc acagacaaat aaggaattta 3815941 gcaataacgc taaagtaaat caatgacccg tacgggattc gaacccgtgt taccgccgtg 3816001 aaagggcggt gtcttaaccg cttgaccaac gggccttcac gaaatggtga gccatgaagg 3816061 actcgaacct tcgaccctct gattaaaagt cagatgctct accaactgag ctaatggctc 3816121 ttaaagatgt cggaatttct atagagcaaa cgacttaaat ctagttctca tcttgtactc 3816181 tattgaagca gtttccgtaa caacgagatt tataatatca cgaacaaata gaagtggcaa 3816241 taactttttt ggtttttttt catatttttt tctcagacca acttatatgc ggctttcaaa 3816301 caaaaaacaa gccccttaaa taggggcttg cagacatatt ctatttagtt cgcacggtac 3816361 acactgcgaa ggacatttgt ttgtgagcgg tctggaccga cagagaaaat agaaagcgga 3816421 atgcctgtca gctgagacac acgctcaaga taatggcgcg cattttccgg aagctcgctc 3816481 aagctcttcg cacctgtaat atcctcagtc cagcccggca tttcttcata taccggctca 3816541 cattcagcaa gtgccttaag acttgctggg aattcttcaa tgatttcgcc tttgtagcgg 3816601 tacgccacac agattttcaa cgtttcaatt cctgctagga cgtcaattga gttcagagaa 3816661 agatctgtaa ttccgctcac acggcgggcg tggcggacaa caacgctgtc aaaccagccg 3816721 acacggcgcg ggcggcctgt tgttgttcca tattcgcgtc cgacttcacg gatttgatcg 3816781 ccgatttcat ctttcagctc agtcggaaaa ggaccgtcgc cgacacgagt cgtatatgct 3816841 tttgatacac cgacaacgtg cttgattttg gtcgggccga caccagaacc gatcgtgaca 3816901 ccgccggcaa ccgggttaga tgacgtaaca aacgggtatg ttccttggtc gatatcgagc 3816961 ataacccctt gtgcgccttc aaataataca cggcgccctt catcaagagc atcgtttaag 3817021 acaacagatg tatcgcaaac atacttttta atctgctgtc cgtactcata atattcgtct 3817081 aagatatcct caagtttaaa cccttctgtc tcgtacattt tctcgagaag acggtttttt 3817141 tcttcaagat tgcgctcaag cttttccgca aacgcgtcac ggtctaacag atccgcgatg 3817201 cgaattccga tgcgggctgc tttatccatg taagcagggc cgattccttt tttcgttgtg 3817261 ccgatcttgt tagccccttt acgctcttct tccacttcat ccaatttcaa atgatacggc 3817321 agaatgacgt gagctctgtt gctgattctc aggttatctg tactcacgtt gcgctcatga 3817381 agatacgcaa gctctgtgac taatgctttc ggatctacaa ccattccgtt tccgattaca 3817441 cacgttttat ccttatagaa aattccagac gggattaagt gaagcttata tgtgattccg 3817501 tcaaacttga ttgtatgccc tgcgttattt ccgccttgat aacgggcgat cacttctgca 3817561 ttttctgata ggaaatctgt aattttacct tttccttcat cgccccattg cgtacctact 3817621 acaactactg aagacatgtc cgtgcacctc cgttaacctt tcaaaacgat tctattcaaa 3817681 caaatcaagt ttatcagtga agaaacagaa agtcaattgt aaatccgaac attaatttat 3817741 tgtaaatcta tattcgttcg cttccattcg ttttataagc gttttctcac tgctttgtca 3817801 taaaaagctt gcgaaacttt catcctttag cataagaaag aatcacttgc ctgatatccc 3817861 ttttgaattc ataaaaacga tccgccagcc gtccgggtcc tctatcgtca cgcccccatt 3817921 gctccagtac gggttctctg attcgacctc ttgatagccc atgtgcttta gctttgaagt 3817981 gatcgctgcc agttcaactg cattcggcac ataaaaaaca agaaggctgt cgggatgggg 3818041 aacgggggca gtgcttcccc cttcatactg ggtgaattcc aaatgataat cggcatgagg 3818101 aaggccgaac atgacaccgt catacccgtt atgctgtgaa aattctccta ttcgtttcaa 3818161 acacagtccc tcttcgtaaa aacgaataat ctcatcaagc tggcccgtag gacgcgcaat 3818221 tcggatttgt gctgcttgaa aagacgaaaa acgttttccc atattgttac catctccttt 3818281 ttgcaccatt ttattaaaac gctttcaatt tttcatccgc tgagcgaacg tcatttcttc 3818341 catctttcga atgaaaaaaa ccccaagagc agctcttggg gcttatgcgc cgggcggaac 3818401 gcctgcgtca tcaaaacgcc gttccaggtt gacgaatttg ttgtattctt ttacgaacgc 3818461 aagagacacg gttcctaccg ggccgttacg ctgtttggcg ataataattt cgataatatt 3818521 tttattctcg gtttctttgt catagtagtc atcacgataa aggaacgcga caatatccgc 3818581 gtcctgctcg atacttcctg attcccggat atcagacatc atcggacgtt tatcctgacg 3818641 ctgctcaaca cccctggaaa gctgagaaag cgcgataaca gggacttgca gctccctcgc 3818701 aatcgacttc agttcacggg aaatttcaga tacttcctgc tgacggttgt cctttgaacg 3818761 accgcttccc tgaatcaatt gcaggtaatc gatcaaaatc atgcccagcc cgctttcctg 3818821 cttcaagcgg cggcacttgg cacggatttc actcactcga atacccggtg tatcatcgat 3818881 gtaaatcccg ctgttcgata ggcttcccat tgccatcgtc agcttgcccc aatcctcttc 3818941 ggtcaggtta cctgtacgga gattctgggc attgatattt ccctcggcac agagcatacg 3819001 cataacgagc tgctcggcac ccatctcaag actgaaaatc gctacgctct catcggtctt 3819061 cgtcgccacg ttttgtgcga tgttcagggc aaaggctgtt ttccctactg aaggacgggc 3819121 agccacaatg atcaagtcgt tgcgctggaa acccgcagtc atccggtcaa gctccgtaaa 3819181 ccctgttgga attcccgtga tatcaccttt tcgattgtga agctgttcga tattatcata 3819241 ggtctggaca aggacgtcct taatattttg gaaggcactc gtgtttttgc gctgtgccac 3819301 ttccataatc gttttttccg cttcactgag taaatcctcg acctcatcct cacgggtata 3819361 cccgtcttga gcaatcgttg tcgcagttct gattaatcgg cgaagaatcg atttttcctc 3819421 aacgattttc gcgtaatatt ctatgttagc cgctgtcggc accgagtttg cgatatctgt 3819481 caaatatgaa ataccgccta cttcttccag caggtctgtg ttcgcaagct ctgatgtaac 3819541 tgtcaccaga tcaaccggtt cacctcggtc accgagcacc agcatcgcat tatagatttt 3819601 ttggtgggac attctataga aatcatctgg aatcaatact tctgaagcca gtgttaaagc 3819661 agacggctgt aaaaaaatag cgcctaacac ggcttgttcg gcttctatat tttgcggagg 3819721 aagccggtca ttcagaaggt ctgtcatgct aagcaccgtc ctctcattaa aaaatctcca 3819781 acctccattc taccatttct acagaaaaaa aatagaaaaa ttgtctgttt cctgtttttt 3819841 tcagttagca gattggatcg tttcggacag taacaaggcg ggaaaaatgc aataaaacat 3819901 aagggaggaa tgaaagatga taaagaaata tgcgattaca cctaatgttg atgcggacgg 3819961 ctggtttatt gaggtggaga atgtagcgcc gacagctttg tatacgtcta aagacgccgc 3820021 tattgaaaag gccaaacagg tggctaagga aaacagtccg tctaagcttg taatttatga 3820081 ccagtttaaa aatgtggaag aagaacactc attttaatga atgaaagcct tcgctgcagc 3820141 gagggttttt tagcggttat cggtttattt catccattgg atgcctatgt gcatcatcaa 3820201 atctgccgct ttttgataca gatcccactc cccgatcgaa gcaaatttcc ccatcagctc 3820261 ctgaagcttt aacctcattg ctatatattc ttcgaaagtg acagcttttt cagtgtctat 3820321 ttggtgttcc ttcagcattt gttttaataa ggataacggt gcgtgcataa gaaccctcct 3820381 tacctctttt ataacggtca ttttccgatt gctctattcc tttgtgacat cttcttacat 3820441 ttcacatctg attcttgtac aatggacaga agagaggagg gatcttttgt gagacctttg 3820501 caaatttctg ccgaaactgc acaaaagctt gcagagtcct tgaatctgcc gcttgaacag 3820561 atcatgcata tgcctcagca tattctgctt gccaaaatgg ctgaactgca aaaagaggac 3820621 aaatcatagc cttcattcac atacttgctt acctgtttcg ggataatatc atgtatatgt 3820681 tagaaaagag gagtaactgc tttgccacat ccacataata aaaaaatcca atcattttgg 3820741 ctgatcaccg gcattatctt tatcgccttt aacttacggc ccgcgatcac ttcagtcggt 3820801 ccggtcatca gctctatccg ggcagagctg cacatgtcca atggggcagc cggttttttg 3820861 accgcactgc cgctgctttc gtttgcagtt ctttctccgc ttgcacctaa gcttggacag 3820921 cgcctcggta atgagcgaac tttatggcta ggtctcgtga tactgctgat cggtgttctg 3820981 actcgttcta ccggctatac tgccgctttg tttttcggaa cagcacttat cggcgtcggg 3821041 attgcgattg gtaacgtact tttgccaagc ttaatcaaac ataaataccc tgaaaagcca 3821101 gggatcatga tcagcctgta tacgacatca atgaatatat tcgcagcttt agcatcgggt 3821161 gtcagcgttc ctttagcgac ccagatgaat ggcggatgga aacaagcctt tctcttatgg 3821221 ggcgggctgg ctttacttgc attgctaatc tggatacctc agctgcgcca tcgagatacg 3821281 gcaaaccaga caatgaagct gcaatccagt tccatttggg cttccaaaat ggcatggtat 3821341 gtcaccatct ttatgggcct gcaatcgttt ttattttaca gcagcatcgc ttggtttcct 3821401 gaaattctcc gttcacacgg gattgatacg gcaacagccg gatggatggt atcactcatg 3821461 caatttgcga gtctgccttc cacttttctg acgccagttt tagctgaccg tgtgaaacag 3821521 cagcgcggta tcgttgcggc gctggcctca gtttatctga tcggcctttg cggattatta 3821581 gcgggcggaa gccatacatt gcttgccatc tggatgatca ttatcggtat cggacaaggc 3821641 tccagcatta gtctggccct tactttgatt ggtctccgca gtgaaaatgc ccaacaggcc 3821701 gctgcgctgt caggcatgtc tcagtcattc ggctacctgc tggcagcagt cgggccaatc 3821761 tttgtcggct atctctttga ccagacgcat tcttggacga tgccgattgt gcttctcatt 3821821 gctgccctga tcgtaatggg agcagccgga cagggagccg gacgagatcg atacattttc 3821881 cagtcagaaa aacaaagaaa ttcagcataa agcggggaag atatctccgc ttttttcttt 3821941 gaatatttat ggtttattca taagtttttc atatttgttt tttacaatga gacaccataa 3822001 agaggtgaaa aacgatgaaa accaaacgat tcgacgcagc ccttattctt attttgctag 3822061 cagcagcttt tttgaatacg tatcacattt ggcaggatga tacagcaaac cagtactatt 3822121 tggcggctgt aaaaagcatg acgcaaagct tccataactt tttttatgcg tcatttgacc 3822181 cttctggatt tgtgacagta gataagcctc ctgtcgtgtt atggattcaa acgattttcg 3822241 cactgatttt cggtgttcac acgtggagtg tcatcattcc ccaggctctt gccggagttg 3822301 gatctgtctt ccttctctac agaatggtta agccgacttt tggagttgga gcggcccgca 3822361 ttgccgcact tgtcatggca ctgaccccta tcgcagtagc tgtcagccgg acaaacaata 3822421 tcgacagcat gcttgttttt accttattgc tcggttcaac ttgtctgctt agggcagtaa 3822481 aacaaggcaa gctggtttgg ctgctgacgg catttgccct gattgggctc gcctttaata 3822541 tgaagatgat gcaagcgttt atggtattgc ctgcatttgt gttattctac ctgattgcat 3822601 ctcgggtttc tctgaagaaa aaaatcgggt ccctgcttct gtctcttgtc cttctgacag 3822661 gcctttcact ctcatgggcg attgcagtgg attcagcctc ttcctcaagc cggccttatg 3822721 taggaagcag ccagactaac tcagtgctag aactggcctt tggctacaac ggcacagagc 3822781 gtctgtttgg gcaaactacg ggccttgcaa agggtgatat gaatgctgct ggcggaggga 3822841 acatgcagaa tcaagacaac atgcaagcgc caaatggcaa cggttcatct ttttctcaga 3822901 acggtaatca atcattcgga aaccattcac aggcgcctca gccgcctaac ggacaaaccg 3822961 gcgctctcaa tggaggcgga ggcacacctc ccacaggtgg caacggacct ggaaatggag 3823021 ggcctggcgg cggaggcgga aaaagcgtga atatgttcgg caccggtgat cctggaccgc 3823081 ttcgtctctt ccaatcagca ctttccggcc aaatcagctg gatgcttcca ttctcattga 3823141 tcggattact gggcgcaatc atcagctggt accgtgatcg ccgcggacat gctgctaaaa 3823201 tgaaagaaac gctattctgg gcggcttggc ttgttcccgt ggctggtttc ttcagcatcg 3823261 caggattctt ccaccagtat tatttgatta tgctggcacc gccgattgcc gccctttctg 3823321 gtatcggatg gtatacgatg caccgcttat acaaaaataa taaagactgg tccagctatc 3823381 ttctgccggc agccgtcttg atcacagccg tgtttcaggt gtatattctg agcgcttata 3823441 caagccaaat cggcagtgta tggatgtatg tcctggggct cttaggactg ggcatcaccc 3823501 ttgcacttct gatgcttaaa cgcagccatc cgttcagtaa gctgctgacc atcatcagct 3823561 tgtgcgttct gcttctcaca ccagtttact ggtcagcaac gccgcttcta tacggtggca 3823621 acagcgtcct tcctgaatcc ggcccgcagc tcaaaggctc agcaaacggc gggaacatgt 3823681 tctcttcaga ggtcgacagc gggctcctgt cctatctgag aaaacacaat accggcgaag 3823741 agtatttatt tgctactttg acaaccgtaa cagctgcgcc atacatcatt tacgaaaatg 3823801 aatctgttat ggcaatgggc gggtttaacg gcacggatcc cattctgact gtgtcggaac 3823861 tgaaaaaact gatcaaagaa ggcaaagtga aatacttcct tctgtcagaa aacaactcag 3823921 gcaacagcga acttgtttcc tggattaaga aaaacggaaa agaaataaca tctgacgagt 3823981 acagcggttc ctccagcagc acaaacagcg tgcagggaat gcgaagagga cctggcggag 3824041 aaagccagca aactctttat ctcgtggaat aaaaaaagag gcttggatga atccaagcct 3824101 cttttctatt aagcttcttc ttttacatgt acctttaaca cagcctgcac ttcaggatgc 3824161 agcttcacag gcacgtttgt atatcctaat gcacgaatgc cgtccggcag ttcaagcttc 3824221 cgcttatcta ctttaatgtt atggtctttt tggagctgtt cagtgatttg cttgcttgtc 3824281 actgaaccaa ataaacggcc gccctcacct gattttgcgc taagctcaac agtcagtttt 3824341 tctaatgtct ctttcaagct cttagcctgc tcaagctcag caatggcttc ttttttctct 3824401 ttctgctttt gtccgtttaa cgcgctgatg tttgacgcgt tcgcttcaac cgcgaggcct 3824461 tttttaatta gaaagttatg cgcataaccg tctgctacgt ttttgacttc gccttttttt 3824521 ccttttcctt ttacatcttg taagaaaata accttcatct ctgtacgcct ccctcaaaat 3824581 actcatctat ggcgtgcttc agccgttcca gcgcttcaga aactgaaatg ccggacaact 3824641 gagtcgccgc atttgttaaa tgccctccgc cttccagggc ctccatgatg atctgaacat 3824701 ttacctcgcc aagcgaccga gcactgatac aaaccgtttg ttcatcccgt ctcgccaccg 3824761 caaatgaagc ctcaacctca ctcatcgata gcagcgaatc ggcagcctgc gcaatcagca 3824821 cttgatcgaa gtattcctct tcattttcag gaagagaagc aatcgcaatg ttatctttat 3824881 agaggaccgt atgctggatc agcttcgccc gtttaatata ggaatcaacg gtttctttca 3824941 gaaacttctg caccagcacc gtgtcggcgc cttttgccct taaataagaa gccgcatcga 3825001 aagtccgcga gcccgtgcgg agagaaaagc tctttgtatc cactattata ccagctaata 3825061 gggctgttgc ttcaatcata ttgattttta agcgcttcgg ctgatattca agcagctctg 3825121 tcaccaattc cgctgtggaa gaagcgtatg gttccatata aacgagcagc ggatctctga 3825181 taaactcctc acctcttcgg tgatggtcga tgaccacgat atgttcaatt ttattgacca 3825241 gccgttcctc catgacgagt gacggcttat gtgtatcaac gatcacaagc agtgtgtcat 3825301 cattggaaat ctccattgct tcttcaggcg taataaatct tgaccacagt tcttcatatt 3825361 ttttgatttc cccaatcaaa cgctgcacac ttgatccgat ttggtttggg tcaatcacga 3825421 taaaaccatc tttgttattt gcctgagcca cctttaaaat cccgatcgct gcgccgatag 3825481 aatccatgtc ggggaattta tgccccatga taatcacatt gctgctttcg gtgacgattt 3825541 cctttaaggc gtgagaaatc acgcgggccc gcacccttgt tcgtttctcc attgggtttg 3825601 ttttaccgcc gtaaaacttc accttgccgt ttggcagctt aatggctacc tggtctccgc 3825661 cgcgtcccag tgctaagtcc aagctggatt gcgccaaatc gccaagttct ttcagggaag 3825721 agactgaagc cccgacaccg acgcttaacg tcagcgctac accgtcaaac gaggtttttt 3825781 cccgcacttc atcaagaatc gaaaacttcg aattttcgag ttcagttaag atatgttcat 3825841 taagtacagc aataaagcgt tctgaagacg tccttttcaa gaagatcccg tactcctgcg 3825901 cccaagcgtt cagcaaagat gtcacctggc tgttcatcgt gcttctcgtc tggtcatcca 3825961 atccttgtgt cacatcatca tagttatcaa ggaaaatata tgccaggacg gttctttcgt 3826021 tttcatatag cttttcaatc tggatttgtt ctgttacatc aaagaaatat aagagacgct 3826081 catcccgttt gatgacaacc ctaaacttgc ggtcattcaa tgtaaccgtt tccgattcca 3826141 cctcttgttt gataagcggc actaccgatt cacaagtatc gtaaagtgat ctccccacta 3826201 aagtgctttc attaaaacaa gaggaaagaa acggatttgc ccattctata taatattggt 3826261 cattaaaaag catgattcca atcggcattt ccatcaatgc ctcttcaccg acttttttca 3826321 acctgtagga caacgtagaa atataagcat caatctcttg tcgaataaga gaatcagcac 3826381 gcttaataaa aaacaaaata actgccagca gcagcacttc gacggttcct aatatccagt 3826441 taaaataaaa gctgatgagg attgtaataa ttgacagagc aatcaatgca tagatgggat 3826501 accgaaacag cggtttttca taaaagcttg gcatttctat cactccccac catgtgagta 3826561 aaactcatgt tcacttcacc ttattcctta tatgaaagcc catatctaaa acgcctaaaa 3826621 tgcgaatggc cgccatgaag accggatgca caaacccaag tatgacagca atcacagccg 3826681 cagcctttgg atattgtttc ttatggcaat agaaaaagat aaatgataaa ccttggatga 3826741 aaatcagaaa cccgagtata aactccccat ttaaagcgat agagtacagc atttggcctt 3826801 tttctaaagg caaaaatgaa agcatgacaa taatcaaata cagtactaca acactttgcg 3826861 gaaacttcaa ctctctaaaa ggctttagat taggaatatc gggggagaat cgccttaaga 3826921 gcggcttagc gataaggtaa ctgaggaaag aaaaaataac tcctaccatc acaatagctg 3826981 ttggaaaaag atattgaacg atacccaatt gttcttccat cagttttaat tgcttctcaa 3827041 actgcccagc attgcccgac tgcttcgcta cagtttctac aatatcaaga gattgccggt 3827101 attgtgtcat tgcctcatca atgatattga tacccaaaaa ctgaatgctt atcacaaaat 3827161 agaagacaat actaagcata taaataagag cgcccgaaat aatggcgtgc ccgggctctt 3827221 tccttttgaa aaaatgtccc atggcaatgc cggcgcaagc tgacataaaa gctacaataa 3827281 gcccgttaaa ggacccgaca ataaaaacaa ccggaagact gacagcgccc atccatatcc 3827341 ctagcttcaa tccatgtctg atcgtataca agatcattgg cagcggcagt gcaaataaca 3827401 gaattgttcc aatcacagga acataaacga ccagaagcgt aatgatcgca aacagactga 3827461 ttaaaatagc accttccatt aaagctctcg tttgtttcac ttagtcacct cgtatcatcc 3827521 tgaacatacg aatagaaaag agcagcataa acgactgctc ttttgttcat cgctgcaaca 3827581 tgctttgcac cgaatgtttt tatatcatct ctaaatttta cttttatatt ttaacataag 3827641 tccaaatcgc aagtaaaatg acgctaatgt ttcatgtgaa acatgaaaaa ggaaaagaca 3827701 ttctttgaaa agaatgccca tcacaattaa tgtttatcat ccataaagcc agaagattcc 3827761 ttgtttttct ttttcgtttt tctgacatac ataaaaatta agatcaccag taaaagggtt 3827821 gttgcttgca gaacgccgct gctaaacaag aaaaagttct ttatcatgtc ccacattgtg 3827881 tttcacctct ttgtgcatgt tctcaacccg tatcctatat aaggtgaatt tcccttttta 3827941 aaaacttcaa aacatcatga acaacattga gcgttgggca tatgctgata tggaatctga 3828001 tcgataaagg agaattttca catggatgaa cgcagaacat tggcttggca tgaaacatta 3828061 gaaatgcacg agctggttgc ttttcaatca aacggactca ttaaactgaa gaaaatgata 3828121 agagaagtaa aagaccctca gctcagacag ctttataacg tgtctattca gggtgttgag 3828181 caaaatttga gagagcttct tccgttcttt ccacaggctc cgcacagaga ggatgaggaa 3828241 gaagaacgcg cagataaccc attttacagc ggtgacctgc tcggttttgc caaaacatct 3828301 gtccgcagct atgccatcgc aattacagaa acagcaacac ctcaattaag aaacgtactg 3828361 gtcaaacagc tgaatgctgc catccagctg cacgcccaag tttatcgata catgtatcag 3828421 catggatatt atccgtctta caacctttct gaactgttga aaaacgatgt cagaaacgcc 3828481 aacagagcca tttcaatgaa ataaaacaag cagcaaagga gttccctttg ctgctatttc 3828541 tgctgatcct tcactaagcc gttcgaacga taagattcca gcacgtctct gttggattct 3828601 ccccattctt tcatttgcaa aacaatcggt tcaagcgtgc gcccaaattc cgtcagagag 3828661 tactctacct tgggcggcac ctggtgataa acctcacggt gcacgatgcc gtccgcttcc 3828721 agctccctca gctggagagt aagcattctt tgagtaatac tcgggcagat tcgccgaaac 3828781 tcattaaatc gtttcttgcc atctatcatg tgataaaaaa gaattccttt ccactttccg 3828841 ccaatgacat ctagagtgaa ttcaactgga cagccttctt tgttcgggta tatattcttt 3828901 ttttcactca ttcttgaccc tccaatagta ccttttttga tactacatta cattttgcaa 3828961 ctaatctacc cagtatttta cacacctttt ctccttagct caaagaaaat gcttcttatt 3829021 cacatcaatt tttaagggtt tgcatgatta cacctgcagc aagacgtgtt aaactatata 3829081 aagattacac tacttaaaaa aggataggag ctatcatgga aaagatactt attttcggac 3829141 accaaaaccc agatacagat acgatttgtt ctgcgattgc ttatgctgat ttgaaaaaca 3829201 aactcggctt caatgctgag cctgtccgcc tcggacaagt caacggcgaa acacaatacg 3829261 cgcttgacta tttcaaacaa gaaagcccgc gtcttgttga aacagctgca aacgaagtaa 3829321 acggcgttat cctggttgac cataacgaac gccagcaaag catcaaagac attgaagagg 3829381 ttcaggtttt agaggttatc gaccatcacc gcatcgctaa ctttgaaaca gctgagccgc 3829441 tttactatcg tgctgagcct gtaggctgta cggctaccat cttaaacaaa atgtacaaag 3829501 agaataacgt gaaaatcgag aaagaaattg ccggccttat gctgtctgcg atcatttctg 3829561 attccctgtt atttaaatct ccaacttgca cggaccaaga cgtagcagca gcaaaagagc 3829621 ttgcggagat cgctggagta gatgctgaag aatacggctt gaacatgttg aaagcaggcg 3829681 ctgatctaag caaaaaaaca gtggaagagc tcatttctct tgatgcgaaa gaatttacac 3829741 tcggcagcaa gaaagtcgaa atcgcacaag taaacacagt ggacattgaa gatgtaaaaa 3829801 aacgccaagc tgaattagaa gctgtgatct caaaagttgt ggctgagaag aatcttgatc 3829861 tgttccttct cgttatcaca gatatcttag aaaatgattc acttgctctt gcaatcggta 3829921 acgaagcagc gaaagtggaa aaagcgttca acgttacatt agaaaacaac acagccctct 3829981 taaaaggcgt tgtttcccgt aaaaaacaag tcgttcctgt cttaacagac gcaatggctg 3830041 aataagcaaa aagcatcccg cgtcgggatg ctttttctta ttcacccagc ttctcaattt 3830101 gtcccatcac atcagtaatt tgctttgcgt tttggaccag gtctgactgc tccaattctt 3830161 taagcgatac cttgccttcc tcggcttgtt tcaacacatc ttcagcgctt ttctgcaagg 3830221 tttcgttatg ctcctgaatg gttcgatgaa tctccgctgc ggcatcaggc ggcgttaatt 3830281 cattaaaatc agcggcagcc ttctgaatcg actcaagctg cgcttcaagt ttttctttcg 3830341 cctcggtgtc atttacagct ttctcagcca attcaggcgc ttcctctgca aatgtcttca 3830401 ccttctccac ataaccagct gcttcactcg tatagttcaa tccgtcgttc acctgatcaa 3830461 gcatgccgca tccgcctgca ctcaaaagtc ccactccggc aagtactgtc aaaatgatct 3830521 tcatcttcag ccccctcatc gtttcttttt cattttttct tttaagatcg gaatcaattt 3830581 ctctttcgct aacggcagcc ctttcctcac caattcacgc ttcagccact ttttcagctt 3830641 agacattctg atgctcctct ccctttttga taaaaatgaa aaaactccac caatttggtg 3830701 aagttcctga aacaaaaaga ccttcaccaa atcagatttg gcaaaggtct cgctaacaat 3830761 gagattgcca gcaaagccga ggacaccttg tcccgtaatg acgactttac tgtgaaagct 3830821 actccccttt ggagtgttca tttttattac tttcattcta aagcaccgat ctgttccagt 3830881 caaattcctg ccgtttatat aaaagcgcgc tgtggtattt aaaatttgaa tggtttttct 3830941 atcaggagat catgctatga cagaggaggt tttcatcatg agtcaagagc gcgtgaaacg 3831001 gcctgggcat accagatggt acatatcttc gttacttagc ggcattatta ttcttaatta 3831061 ttttgaccga gtggccatct cggtagcggc ccctgcgata caagattcgt ttcaccttac 3831121 tgcaactgaa ctcggcatcg tgttttccat ttacacctat tcctatacac tgatgcagct 3831181 gcctgtcgga agtttgctgg accgttttgg ggtcgcatgg gtcacgaggg ttggaatgac 3831241 aatatggagc tttttaacga tccttcttgc ttttttgcaa ggaaaattgc tgttgtatct 3831301 gttccggttt ctcattgggc tgacgagcgc ctctgcgttc cctgctgcct ctaaagcaac 3831361 cgctctctgg tttcctccaa gtgagcgggg attggcaaac tcactgttcg attcggccgc 3831421 caagttttca aatgtaatcg gcgcgccatt ggtcgccttt cttgtcacaa catttgactg 3831481 gcgtgtcgct tttttgacga ttggatgcat caatgtgctg tttacgatct ttttctggca 3831541 gtattatgaa cagcctgaac ggcacaaacg catttctaaa agtgaactaa actatattca 3831601 aaaacacaat gccattacaa cagagcaaat cccttacaaa acgggcccgc ttttaaaaaa 3831661 gcttttcacc aatcgaaaag tatggggctt aatgatcgga tttacagggt acgggtatac 3831721 attcaacctg ctgctcacct ggcttccgac tttctttaaa catacatacg gtatggatct 3831781 catgtcgtcc ggtttattta cggcagtgcc gtggctgatc tcaaccattt ccggaattgc 3831841 cgtcggcggc tggctcgtcg attattttat taagaaaggc tatcctaata ccaaggtgta 3831901 ccgaaccgta atcatagtcg gaatgagctt tggctttttc tttttaggat ccattctgac 3831961 gaacaatatt accgtagcca ttatttgcat ttccatcgga ctcgccggaa tttccgcaac 3832021 cgctccggtc ggctggtcca tctccgcaga actcgcgccg atcggttccg tatccatgct 3832081 gagctccatg gtgaatctcg caaacaacct gttcggaggc attattgctg cgtcactgac 3832141 agggtatttg tttgatgtga caggctcctt taccctcagc tttctggtag ctggttttgt 3832201 gctgttgctg ggattggttt tttatgtgtt tgtattaggg gatgtaaaac gaattaaact 3832261 atagaacatg aaaaagagag ctgccagttg gcagctctcc ctttacatca aagaatcggc 3832321 ccgtccccat ttaccttctc ctcgtcctgt tcctctatat caagccccga agctagcatt 3832381 tcctgctcta tctgttcgag cacctgctcg ttttttcctt gaagaccacc ttcataatga 3832441 aaagcatcct gtgtgccgtt ttcctctatt gtcgctaaaa tatcgtggat atcattatgg 3832501 tctcctgaaa tggagccgaa tccctggttt tgttttttat aattcacaaa accgctgggg 3832561 aggttgtttc cgaggtttac acatgatgcg ctccgagtag taattcatca gtgtatcaaa 3832621 atcttcattt tggattgcca catcacatgc agagatgatg tctttcaatt gctgttccaa 3832681 atgaattccc ctaatcatca tgattggata tattatacaa tgtttgacac gtagggatcc 3832741 ttttcatttt tgtttttacg gtttcgctgg tccatttccg cagagctggc gccgatcggt 3832801 tccgtatcca tgctgagctc catggtaaat ctggcaaaca acctgttcga aggcattatt 3832861 gcggcttcat tgacggggta ttttgtttga tgtgacaagg ctcctttacg ctcagctttc 3832921 tggtagccag ttttgttctg ctgcttggat tggtttttta cgtgtttgtc ttaggggatg 3832981 taaaacgaat taagcgggaa taaagagtgc ttgtagagaa aacgttgttc tttctacaag 3833041 ctttttagtt ttgtgctgtt tttcaagata ttcagctgtc ataaaaagaa aatgagctcc 3833101 cacataccgg ctaggtatgt ggcgttcttc ttcatgttct ggcatgcagc tgtgaggagg 3833161 atttgtttgc tcaccccctg aacctgcgat agctaagccc gtgcagttgt tttgaaccta 3833221 caaagcttcg ttctattttt tcttttcttt ttttagagat ttcctgaaat agaaaagcaa 3833281 tcttttctaa ccttttcttt atggttttgc catacatacc gagtaacgac tttctggcgt 3833341 ttcgttgatt ttgtgtaata ttctcaaaca tatttcagga tttgatttat atgaccgata 3833401 gtctttgcga tcaattgttg agtacgtaag tgtatgctga ttcaacaaat gtatctgtat 3833461 tgttcacttt ataatgaaat ttccattttg gaagcaaacc cctgactggg tgataacgtc 3833521 tatgtgcgat ggcaccaaaa acttggaggt caaatagtcc tttagagatg agagttgtta 3833581 agtagccgga atctagagcg acggcttcta cttgaaaatc aaatcatgca atttagtgat 3833641 ccaatcggtc aaggtagggc ttggaacaga atcatggact tttctggagt tgcaaactat 3833701 taatcgtcct cattaaattt ataataaaaa tattctcaat tgagcaaatc gcccaccctt 3833761 tttcctttat aacataaaat ccaatactat caataaaatt ctttacaggt tattacagtt 3833821 aagatataat atagttaatc ttttacgtaa aaggaggttt ttattacttg tgttgaagtt 3833881 ttaaatagga gtaactccat ctccccatta cggtcttcat ttaatttcat cctgagtttt 3833941 atttagttag atataaaaac gaaaatttca cattattttt aactaaccga tagtataaaa 3834001 tatatattga aaggattgta aaattatgaa taaattcctg aagagcaatt tccgtttcct 3834061 tcttgcggct gctttaggca tatcattact tgctagtagt aattttataa aagccagcaa 3834121 tgataactat aaattccatt tacttgtacc ttatggctat ggtaatgcct attcaaatga 3834181 tgcatttaga cagaccactc atacagataa tccttggaaa gtaaatttac agaaatcggc 3834241 agaaggtaaa ggtacaatca tgacattttg gttgattaac acagggaata gtaaaattcc 3834301 aaaagcttct aaaatacata acgtaaaaca aggaagcgga gctcattatt atcatgcaaa 3834361 tagccaggga agccatacat atgtagcctt agcagttgaa aacaacaatt acagtgcaag 3834421 ttcttatggt atagatggtg tatgggatga agaaacttgg taaacaagaa ccttctaaaa 3834481 acgttggcac cttttagcca cgcgaaaaaa tttagaatga taatcttttt ataagattat 3834541 catttttatt tattctatta agaattgagt gagaacatgg aaagtcatat ttatcgcatt 3834601 atcaaaaata aattaactat aataatattt actataatca tattaattcc ttgtgttgat 3834661 atatcactat tgttaatgac taacacagaa taccatcctg catatgcgtt tttcctttct 3834721 ggcacttccg tagggcatgc ttcacaaatg atcctattat ggtttcttcc gctttatttt 3834781 ttgttactat gtgctgacga ttctatacaa gattataaaa caggatatca ttacattctt 3834841 ataagcaaag ttggcagaaa aaaatattgt ttggaaaaaa tatttacctc ttttatcatt 3834901 tcatttttga caatgttttt gtcactaata ttaaactttt tattggttca ggttttcttt 3834961 tttaaaggta catttaaaaa tgacttagac caaattaaat tccctgataa cagcctttat 3835021 acttttagta tggcccatcc ttatatagca attgtgttat tttctattat ttgttgtatt 3835081 atgtctggat ttgttggagc acttggttca agcctcagtt tactttttcg tgataagaag 3835141 tatgcctacc cagcaagttt ttttatttgg ttcgtactta tactaaaaaa caaatcatta 3835201 atgtttttat tccaaccgtt tacagaatac ggttataatg tacttctccc tatcctatgt 3835261 ttgtctatct ttatttttct aataataatt tctagtattg ttttatatga ggcaaaatac 3835321 aatgaaaatt aaaagactac tattaatttt atgtttacta ctatttttag ttactttatg 3835381 gttcaaccag aaccacactt atcttggaaa gaattctatc gcgtcattac tatatatgaa 3835441 taatagtaca ttcggatata gttcaatatt tgcatatacc ttgttttata ttgtcccgtt 3835501 tcttatgtta cttagtaact tttttcattc agaaaacccc tacaaagtaa tgaggatggt 3835561 taagcgtaaa aattactaca agtctaaaat tatggagatt gggtttgttt ctttactttt 3835621 ttcttcaata catactgtta ttaatattac gtgtacacat attttcttta gtaaaaactt 3835681 gttggtcgaa gcaaactttt tatcaatttg tttattaaac atgattagtt tagtgttttt 3835741 ctacttatca gtaggtatta tgtttagact tacatacgat ctgtttaatt cagtagcatt 3835801 agcaattttt attgtgtata taattttaga tagcttgtat ttcggcgtta aattattact 3835861 tcctaatgga tattgggaac cctttagaga cttggctata ttcacaaata tgctcaatag 3835921 atattggtca acttcaaatc ttataatagt ttatattaga cagataataa tagtttttat 3835981 tttttattta gttggatctt caattttttt gaataaggat tataaaaaat gaggattaaa 3836041 ggctttttca taactttagt tgcgataata tttcaggcgt cattatcgag ttataataat 3836101 aataaaaatg tctttccttt tttagatggc ataccaataa gcacctcggg tcattatgag 3836161 tatcaaaata ttttattgtg gtttgtacct attgtttccc taagtttttg tttctctggg 3836221 agtattagag atacatacat ttcgtatgag caattaaagt tagtaagaga acatagtaga 3836281 gttaaatggg taacatctca attcttaata attacagttg tacttttaat ctttacttta 3836341 tctcagattg ctatatttta tatttattca cttgtatctc ttcataacct tgatattaat 3836401 tccgttatca ataaaagatt tgttatgatg acactcatgt attatctaac cttacttaac 3836461 ttatttagtt ttcaattatt tatggagctt tattataaat ctcaaatagc acaattaaat 3836521 ataagcgttt atattatttt ttcgttaatt ttagcaaaga agttagtgca attaaattct 3836581 ccgaaagtta ttcactactt tttaattcca aactacagta atggattaag aactgggtta 3836641 agctattatt cccaatctgg aactgctatt attgaaccat tattaggttt gtttattata 3836701 atcattttac agatttcaat agttatatta tctgtcttaa agttcaaaaa aatagatatg 3836761 ctaaaaagtg agggcttaca atgattgagg tattaaacct aacaaaaaaa ttaaaaagac 3836821 tacagtttta gataatatct cttatacatt tgaaaaagga acaatttatg gactatttgg 3836881 gagtaatggt tctggaaaga ccatgctact tcgtgcatta tccgggttaa tagtccctac 3836941 tgaagggagt ataactatta aaggtgaaca attacataaa gatatctctt ttcctaaaag 3837001 tgtaggatta attatagaaa atatgcagtt acttcctcag tatgatgctt ttactaacct 3837061 taaaattttg tcaaaaatta aaaagatcgc atcagataat gatatattag attctattag 3837121 tagagttggt ttggaaaatt ttaatagtgt aaaggttagt aaattctcgt taggaatgaa 3837181 acaacgatta aatattgcac aggctatttt tgaaaaacct gatatattgc tacttgatga 3837241 accaacaaat gcgattgatg aaaaaggagt tgcatttgtt catgacattc ttttacaaga 3837301 gaaaaaaagg ggagctacca ttattattac tagtcatcac aaggaagata ttatatcttt 3837361 atgtgacatt gcattagaaa tgaatcatgg acgtctagaa acttcagaaa aagtaatata 3837421 taagaaagat agttagttta aactggctat ttcttatcca atgatagact gcagacaagt 3837481 tcaactgctg taatgctaga aaatccaatg aaatgctgat aattgcgaag agatatgatc 3837541 agtcagaaaa caaatcttaa aaagaaaaag taaattcatc aatatttcta ataaacctgg 3837601 caaacaacct gttcggaggc attatagcta cttcactgac gggatattta tttgatgtga 3837661 caggctcctt acgctcagct ttctggtgcc ggttttgtgt tgttgctggg attggttttt 3837721 tatgtgtttg tattagggga tgtaaaacga attaaactgg aataaagagt gcttgctgaa 3837781 aagcactctt tttctgcatc gaaagaatac ttaagataag tcactcccaa aaatcgtaac 3837841 agtctgacgg ttaaacataa acctctgccc gttccatttt aatacggttt gaacatatcc 3837901 caatgagtcg gcgttatacc ttcccgctat ccgctggtac gccaataatt cgtatacgcc 3837961 gtctctgtca aaatcaaccg gatacaagcc cgataaagga ttcacccatc cttctatcgg 3838021 catttttaac acaccttggc tgttataaat ctcattcaaa tattccctgc ccttgtaagt 3838081 aaggtcgagg atatacgttt cgttttgctg atgactgata acgctcgctt tatattgatt 3838141 ttgatacctc acactgtact ttaattcatc attcaataca tctgaattga aaattcgccg 3838201 gaactgcctg tttagatagg caaacacata tgcataaata gcaccgccgc ttccccctgt 3838261 gtccattact actgccacat cctcaatctt gtcgcctgtc atatccccca gaaaaagtga 3838321 cggattgtat cccatattgt tttgaagctg aatccgctgc tcctgatggg ttctgccatc 3838381 acggatcacc aatgtgatat ttctccataa cgggctgccg ggcatttgat ttccagttag 3838441 aaagacctcg tcaataacgc cgtctcccgt tacatcgccg cgggtagata caatgattgc 3838501 acgtgaggag acaggctgcc gaaatacgta tggatgttga acaagtcctc tgccttcata 3838561 aaaccaataa ggagccattc tgatgtcata cacattcaat tgtgtcacct tccctaatca 3838621 gctgaatgaa tcattatatg caggaatggc acatcaaaga catatcttac acaccaatta 3838681 aatccgtacc atatgaatta tcaattacac aaagccactc gccttgcgca ttctttttaa 3838741 atacataggt cgcccttctt tccatcgcat actcggagtc ctttttatcc gaatcaagca 3838801 gtgtctgaga aagaacgagt accgtgtcac ctgcttccaa caggatcatt ttcccttgtg 3838861 tcgggacaat atgatgattg aaatagttcg caatcgtgat aaacgctttt ttgatttctt 3838921 ccttgcctcg cgcgatcatg cccggcttca caactaaaac ggcatcttcc gaataataat 3838981 tcatcagtgt atcaaaatct tcattttgga ttgccaaatc acacgcagag atgatgtctt 3839041 tcaattgctg ttccaaatga attcccccaa tcatcatgat tggatatatt atacatcgct 3839101 agaccactga aaccttgaaa acaaaatgaa aagtatcctt ttttcctata taatcaaata 3839161 gatatattta acaaagtacc caagtgaagg ggtgaacatt attgtctgcg gaagtaacgt 3839221 tacatgacaa tatacattat gatttaagtg cggattgcca gcactgtttt ggcctgtgct 3839281 gtgtcgcctt gccttatgcg aagtcggcag attttgcttt tgataaagac gggggcacgc 3839341 cttgccgcaa cttacaatca aactatcaat gttctataca taaagatctc agagaaaaag 3839401 gatttcgagg ctgctctgca tatgaatgct ttggcgccgg ccaaaaagta tcccaaatca 3839461 cttatgaggg aaaggattgg cgaaacagcc ccgaaacggc caaccagatg tttgacgttt 3839521 ttcctatcat gcagcagctg cacgaaatgc tctggtattt acatgaagct ctttctatag 3839581 atatagccaa gccgattcat tctgaactga gaaccacttt cgaaaaaata gaaaggctca 3839641 ccagactcag caaagaacgc ttgctgacac tgcaggtgga cgagcatcga gctgaggtca 3839701 atgaatggct gttaaaaaca agtgaactgg tgcgtgccca agcccgccat ccaaaactcc 3839761 cgaaaaaggt cagccgggga agtgtcctga tcggcgcgaa actgaaaggg cttgatctgc 3839821 gaggagcaaa tctaagaggg gcgctgctca tagccgccga tctgagaaat gccgatttga 3839881 gaatgacaga ctttatcggt gcagatatga gagacgctga tctcagcggc gccgacctga 3839941 ccgggagcat ctttttgaca caggcacagg tgaacgccgc caacggcgat tcgaatacaa 3840001 agctgccgct gtctgtacga acccctgccc attggaaata aaaaaggacc cgctaacggt 3840061 ccttttttac tgatcaattc aatccttttt cgttcctctt atccggcatt ttcacacttc 3840121 ttgccaagta tcccgacagc cataacgcaa ccagcagcat gaaggtgatc ataccgacga 3840181 cgcccagcca gtgaaaacca gaccagaata gccctccgat tgttccgaaa acacttgaac 3840241 cggcgtaata aaagaacaaa tacagcgatg aagcctgtgc tttgttgtga agggctctcc 3840301 tgcccaccca gctgctggca actgaatgcc ctccgaaaaa accgaatgta aagagggcaa 3840361 tccccagaat tttcactgcc agcatattgt ttatcgtaaa taacgcacct gcaatgacga 3840421 tgaaaatatt catcaccaat attttcggat agccataccg atcaaccatt cttccaatga 3840481 aagacgagct gaaaatgcct acaatcatca caataaagat ccagctggaa aatgctttat 3840541 taagcgaata cggcgggccc aacagcacat acacaatgta attaaacaag gcaacattgc 3840601 ttccaagcag caaaaaacca atgagaaaca agctgaatag tttacggtcc ctcaagtggc 3840661 cgatcagaga cattcccaat ttcccgagct tcaattttct tggcgtaaaa tgcctggatg 3840721 gcggcaaatt tataaaaaat ataacactag caatcaaact aatgacacca attgtcccca 3840781 tcgccatatg ccaattcaag tactcgctca ggagcccgga aacgatcctt ccgaaaacgg 3840841 cgccgattgc atttccgctg atatatagcc ccatcgctga tccaagactt ccgggttcaa 3840901 tttcttcccc aagataagcc atcgcaatcg acggaaggcc tgcgagcgca acgccttgaa 3840961 tggttctcaa tacgagcagt gtatgaaagc tcggactaaa ggccgatgcc agacagagaa 3841021 ccgatgcggc cagcatggaa atacccataa taggcttgcg tccccacacc tcggataatg 3841081 aaccaaagac aagcatgctc acagctaaca gcattgtggt aacagataaa gaaagactcg 3841141 ccgcagtagg cgttacatga aattcccgcg tgaattcctc catgagcggc tgtacgcaat 3841201 atagaatcgc aaatgtattg aaacccgcag cgaagaaagc aaacgtaatt tttcgaaaaa 3841261 ccggtgtgcc ttttcgaatg tatgtcatcg ggactttatc ggtccctcat catgttgtgg 3841321 agcactgcca ttcataaaca atcatccttt atttcttacg aattcaaaca tcctcgagtc 3841381 tgtttatatt attatcttag caccgttgat atatgttgta taatgcatat aaaatatcct 3841441 tttcatgctt atatgtaata aggagagatg ataattggaa tgggaacaac ttgaatattt 3841501 tcaaacactg gcccggatgc agcacgtcac gaaagccgca aaaagcctct ccatcacaca 3841561 gcctgcactt tcacgctcta tcgccaggct ggaaaatcat ttgggcgtcc cgctatttga 3841621 caggcaagga cgatccatca gcttaaatca atacggacac atttttttac gacgggttca 3841681 ggcgatgatg aaggagtata ccgaaggaaa agaagaaatc caagccttat taaagccaga 3841741 ccaaggcgta gtctctctcg gttttttaca tacattaggc accacgctcg tgcccgatct 3841801 catcggctcc tttcagcagg aataccccaa catttccttc cagctgaagc aaaaccactc 3841861 ttattggctg cttgaacgat taaaatccgg agatctggac ctctgtctcc tcgcttcgat 3841921 taagcctgaa aatccgatcc aatggatcaa gctgtggagt gaagaactct ttgtatttgt 3841981 gccaaatgat cacccattag ccagtcgcga aagcattacc ctgaatgaga ttgccgggga 3842041 gcgttttatt ttattgaaaa agggctatgc gcttcggatg acggtcgatg agctgtttga 3842101 gaaggccaat atacagccga acattatgtt tgaaggagaa gaagcaacta ctgccgcagg 3842161 ttttgtggca gccggtctgg gcatatctat tctcccagac ctgaaaggct tagaccaaag 3842221 caaaatcacc aaaatccgcg tcagctggcc ggaatgtcag cgtgtcatag gaattgcctg 3842281 gataaaaggc aggtttttat caccggttgc tgagaccttt aaacaatatg tgatcagcca 3842341 tttttctgag taggaaggat tcaagcatga atgtcaaaaa aatcacgtca gaacaggatt 3842401 tacatacagc gtttgaaatc agaaaggcag tatttgtaga ggaacaaggc tgtcccattt 3842461 cggatgaatt cgatgagttc gatacactcc acggtgactg ccagcacatc ctggcttatc 3842521 atcagaatgt acctgttggc actgcacgtg tccgtatcgt tggccacacg gggaaactgg 3842581 aacgaatctg cattctgaag tcttaccgca aattcggttt gggaaaagtg atcgtcgatg 3842641 cattagaacg tattgtaaaa gaacaaggca tttctgcctt caaactgcac ggccagacac 3842701 aggcggcagg cttttatgaa aagctcggct atcggactgc atcagaagaa tttatgctgg 3842761 acggcattcc gcatgtgctg atgacaaaac aagacgattc tgcgctatag attgttcaca 3842821 aatttgtcac ttatgagcat gaacggttca ttggtatact aatcaccgat tatggagaga 3842881 aggaatgatt gtatgccagc aaataaaaaa gaaggcctta tatttggcgt gatgatgtgc 3842941 tttggaatgg tttgcgtcat gtcgatttac aatgccatca tcaaccgagc catctacgat 3843001 ttttcactga tgaccgtttt tgaaatggtc atcggtttta tgatcgccct cctgttagat 3843061 ttactgttag tgggccccct cgccaagaag attgcattcc gcatgccgtt cgacaagact 3843121 aaaaaaattt atgtcatcct tgccatgtca acttgtatgg tgattggcat ggtactttgt 3843181 atgtctgtgt tcggtttagt gacagcggtt ctagcaaatg ggctgaacgg ggacagcctc 3843241 ttcagtgctt atcttatgat tgtgttgaaa aatttcatcc tggcctatcc gttgcaatta 3843301 ctgattatgg gcccattagt cagaggagtt ttcatgaaat ttgtaaaacc aaagctcaca 3843361 gccgcaattt aaatagaaaa ggagtgagcc tgacactcac tccttttgct catgaatcga 3843421 atgtaaaaca agctccgcaa aagcctctgc ggcaggcagc tgccattttt tctttttggg 3843481 tgtgagtaaa tcggatcgag ggcttcacca tgctggagat ttttcagctt atgtttttca 3843541 cttccattaa tccctatacc ttaccacata gtttttatac aattcttcgt tataaaggat 3843601 ttcttcgcca tgtgaagagc aaatgagcgt tggtttgatt tgatctatga ttgagccgct 3843661 gtcgatgttc tcatttatat caacactgaa tcttcttata ggtgggtgta aatcctcctt 3843721 acttgtgata aaaaggtcgc ccgtcaatag cgtacgatcg attttatgat aatacacaac 3843781 atgccccggc gaatggccag gtgttaaata gtatttcaga ggcagatgag caagcgtttg 3843841 ctccgtcagc ggctgtacaa tatgggctac ccctgtgttc tccacttcat ttttgttcgg 3843901 atatggctct tccccattga tgtactttag ttctttctgg tgcgcaaaaa tcggaatatc 3843961 aaatctctct aaccattttg atgcaccccc gatatgatca ctgtggccat gggtaagcaa 3844021 aatggctttt ggattgccga tcgctaacgc tgccctaatt tgagcatcag caaaacgttc 3844081 tattcccgta tcaacaatat aaacatcatc accatctttg ataaaccagg tatgaaccgg 3844141 aatacgaaga ggcacatcaa gctcaaattc acattgaaag acatgttctg atagttgtct 3844201 caaattcacg caaaccatct cctgtggaaa ttttttgata gttttaaaga aaacagaagt 3844261 gaacggacta ttttcaccca cgctcgagct gactggattc ttgagaggaa acgccgattt 3844321 tcgccagcat cagctcaact tgttaacgtt gtccattaat aatccctttt gttccccttc 3844381 ttcacatatt cccaatcacg ttctatattc ttcctcactc tatgaaggag tgcagaaatg 3844441 gtttcctttt cctctgaagt aaaaccggac aaggccactt ccgtggaatg ttctccttct 3844501 cttcttaaca atggatatac ctttttccct ttctcagtcg ggaacagttt ttttattttt 3844561 ttattttgct catccggcag tttttgaata aatccctgca tttccagctt cttaatggcc 3844621 cgcgcggccg ttgtccggtc cacttttatc atttccgcca atttttcttg aataattccc 3844681 ggattttcgt atatacgcac gagatagaga tactgccctc ttgttaagtc taaatcttta 3844741 aattcgatgt tgcttatgga atccaacgct cttgctatca tgccgatctc acgcaaaata 3844801 tcattcattc ctaaaacccc tcacgtattt ttgttgcaat tacaacaaaa atgttttaac 3844861 cttactatta taagaccaca tgcgtgctgt acagtccaga ctaatatcag aaaaggattg 3844921 attcataatg aatataaaaa gaataacaac tgaagctgat ttacatgaag ctttaaagat 3844981 tagaagaggc gttttcattg aggagcaaca tgtgtctgaa gccgatgagt tcgatgaatt 3845041 tgatacgctt caggaacaat gccagcatat cttggtatat catgagaatc agcctgtcgg 3845101 caccggacgc gcgcgcatcg ttggccatac agcaaagctg gaaagaatct gcatcctaaa 3845161 accttaccgt aagtacggat tggggaagat catcgtaagc gggttagagg aaatcatgaa 3845221 agaaaaagga ctgacttcat ataagctgca tggtcaaaca caagcggcag gcttttatca 3845281 aaaactgggc taccagattt cttcacagga atttatggag gacggcatcc ctcacgtctt 3845341 gatgacaaaa gaaatatcgc ggaatataac atgaaatata tgtattacgg aataggcata 3845401 ctcatattaa gtttgggcat ttccttaacc atacaatcag gactgggcac atcacccttc 3845461 gatgcccttt tggttggtct gtcaaaaaaa atcggtctta ccgtaggaag ctgggaggtc 3845521 cttatttctg tgatcctctt aatctgcaac gctatattaa cgagaaaaaa acctattttg 3845581 ctgggcttga ttacagcatt cattactgga ataggcattg acctatggtt gtttgttgta 3845641 aaaaacacca tctatctaaa ctcgttgtta agcaaactga tttgttttgg aattggtttg 3845701 gtgctcatcg gtcttggaac agccatctat cttcagacga aattcgcatc aacaccgatc 3845761 gatcatttaa cacttattat ccgagatctc tccaaaagaa caatattgtt ttcaaggaca 3845821 ttggtatacg ctcttttctt agtattagcc atcatcttta aaggccctat cggcatcgga 3845881 actcttttaa cggtttgttt gggaggaatg ctccttcacg tttttatgcc tattgtggaa 3845941 agacatttct tatcaaagaa tagaagaggt tattaagaaa cctcttctcg atccaaaaaa 3846001 cgaaacgcaa aacaagcccc gtttcgttgt caattcttta tctctggtac tgttgaggtt 3846061 ttataatcaa ttaaaattta tagtaccaaa aaatcgcaat ttcatttgct gttggaaagt 3846121 tggaataaag catcgtatca accgcaccta ttataaagtg atgtttggca taaaaatgac 3846181 aagctgaaat attaatatct tgggtttcaa gcataagacc acaaaaatga ttctcctttg 3846241 cccactcaat cgctttatgt aataatgctg ttccaacacc tttttttcta tagtcttttg 3846301 ccacggcaat gtcctctatt agtgcatacc cattccagtt agaacggatc ttaatccggc 3846361 caatgcagtt gttttcaaga taatataaaa aagccgcttt cccctcttct tcaacataac 3846421 taacatccat gtcatcatct tcatattgtt taaaataagg tttagaaaat cgttcctcag 3846481 tatatgtcca aacaccgttt tcaaaagcag gtatcattct cccaaaaaca acgaaaggtt 3846541 cgtttggttt attgaaatct ttcatattca aatgagtcat tttcatgatc atatcaatct 3846601 ccgccaatcg agataatatt tagtaaactc gtttcgatac tattcaacaa cagcttccaa 3846661 aagtgtactc tttaagagaa cagcattaga taaggcatcc attaccttat atatttcact 3846721 atcttaatga ggtatttcaa cagaggcttg tggtacagta aaaaggaata gaaacaagag 3846781 aaaagaagat gaacctatgc ccactaacaa taaactcaat gagaaatatc atacttcctt 3846841 caactcgccc acaaccctgt tgactagtat ccgtggagag aggaagcttt gacacagctt 3846901 ctgccattga tgacatctct attgaagtat ccaaaggaca accaaggatc gctctttgac 3846961 tttttcaaga agaaagtaga gtgaataaag gagtgattga gtatgttaac aagagaagat 3847021 atctttaaac acgtcaaaga aaaatacggt acatcgcctg attacccgtg ggagaaatac 3847081 ccaaactatg cttctttgag acatacatca aacaaaaaat ggtacggtct tatcatgaat 3847141 gttctcccag aaaaattagg cttggatggt catggcgaaa tagatattct aaatctaaaa 3847201 tgtccccctg aaataagtga tcgcttaaga aacggggaaa atatcttacc cggatatcat 3847261 atggataagg aacattggat ttcaattgtt ttagaacgga cagatccaga aggcgaaatc 3847321 tataacttaa tcgagcagag ctttcattta accaagtgaa gataaagagt gttcctgcta 3847381 atcaagctgc gaagagtagt gggcactttc attttaggat actgttcttc actctgtcca 3847441 caaacgcaac ttagttcatc tggtgcgaga gtgggagaag aatttcaacc aacttcttat 3847501 gtaaaaggat gaatagttat gacaaataac ttaaaacaga gaagaatcat tttagattta 3847561 gcagttactt tagatggttt tattgaaggg aaaaatggag aagttgattg gtgtattatg 3847621 gaccctgata tggggtttac tgatttttta aatcaaattg atactatttt atatggtaga 3847681 aaaagcttcg atttatgggg acaatacatt ccaaaaaatg aagaccctga tacagaaaag 3847741 gaactttgga aattggttca tagtaaaaag aaatatgttt tttccagaac acaaaatgag 3847801 attgataatc aagccatatt tataaatgat aatattcttg aagaagtaaa taaattgaag 3847861 aaaaatcctg gtaaagacat ctggctatat ggtggagcga gtctcattac aacttttata 3847921 aatttggggc ttgttgatga atttagatta tctattcacc ctgttgtttt gggagaagga 3847981 aaaccgttgt ttattgatgt aaaacagagg ataaatttaa aaatggtgaa tacaagaaca 3848041 ttttcctctg gcgttgtgca aatcgtttat cattggaatg gctaacattg taaagtaaca 3848101 ctcgacagta atccttctta ttgaactaaa ggggaatcca taaataatgg gttcccctta 3848161 atatactatg gaattatcaa tatcaaattt tctgtaataa aagaggattg aaaaggacga 3848221 tgtctcctca attaacatca ttaagcatta tagtatattt tcttctccct cttttaagta 3848281 atcggctaag ttttgtattt ataaaaaaac gaaagaaggt gatccaatgc ctactaacaa 3848341 taaacccaat agattaatcg ctgagaaatc tacttatttt acttcaacat gctcataacc 3848401 ctgtggactg gttcccttgg ggagaagaag catatgaaaa agcgaaacgc gaaaacaagc 3848461 ctgttctcgt atctattggg tatagctaac gatggctaat ctaaagaaca tgctattgat 3848521 gccatgttta ttcattttac aaaaaaggat caaccttgaa ttactttcac aagattgatc 3848581 ctttcactca tttagccatg tctccgcgaa cgtttatata cattcaagat tactagccaa 3848641 caaataacaa tgattcctgc aaaaagtatg agcatattgc tatacaaata ggtagagtga 3848701 tcaacgtcaa taggcagcag cctatgatct aggaagccga tagataataa accgcctaca 3848761 atcgcaatac ccgttccctc tgataaaaag ctcgtgaaat taagcaaact cattccagcg 3848821 cccgcttcct tttctttcaa actgctagac acaactgtag atataactgt ttttgtgaaa 3848881 gatagccccc caaaaacaaa aattactata attgtcatga tccatggtgc tgcatctata 3848941 aaaaaggcag cgattaaaaa gccggaagaa agcaatgcac ttccaatagt tagtacatac 3849001 aaggaacctt tccgatcaac aagcaatccc ccaatgtaac caaagatgat gacactcatt 3849061 gttccgggga aaataatgcc gcttccaatt gctgcagtac ttaaatggtg aacatctttc 3849121 atcatgtaag gaaccataga gacaaatcct gctactgtac caaatattag tcctccgcaa 3849181 agggttccaa tcacaaaaaa gacgtttttc cctaattcag ggtcaacaaa agggtcctga 3849241 gctttcctaa tgtgttgcac aaatatgaag aaagcaagga tactgatgat cagaaaagaa 3849301 aatctataag atgttgtaaa cagcataaaa aatacgatac ctgcagacat caatataatc 3849361 cctgccatat caatgtgtcc tcttattctc tcttcctttt tcaacaattt tataaggaat 3849421 ggaacggtga taattgttgc agttggaata agcagcaaat acgaccaatg gatataatga 3849481 gcaaccattc cgccaatagc tggcccaaca ccttctccca ttgctaccag ggacccgatc 3849541 aggccaaatg ctttccccct gttctctttt ggaatatagc gcgcaacgac aaccatcaca 3849601 agagctggga atgcggctgc accaattcct tgaataaatc gggctagaat gagaatagga 3849661 aagaaagagt gtccaacaaa tccaatgatc gaccctaagc catttaccat aatcccaaat 3849721 agaagcagat ttttgatgcc cagctggtct gatagctttc catatagagc tgttccaatg 3849781 gagaaggtta acataaaggc tgtattcacc cagtttgcac ttgctggcag tttattaaac 3849841 tcgttggcaa tatcaggtaa tgagacgttc agaaccattt catttaatac gctgaaaaat 3849901 gatagaacac aaagccaaat caaaacttga ttgtgccgta aagttgactg tgaataagac 3849961 gtattcacaa tttcccctcc attaatgagg gcagacgcag tttatagggt cattgatacg 3850021 cttccctctt ttaattgtac cctgttcatt ttattgcact tcataataac tccccctaca 3850081 tttgattgat atgatcttat tatatataga ctaaggatta aacttttact ttttttataa 3850141 aaatttgacc agattgcgaa acaaggaaaa acgttattcg catttatctc aagtggcaaa 3850201 atgaaacatt agtttatatt ttcacatcac aattatcgat aagcagtcag ttattgtatt 3850261 tgtttaggat aactgtggta acctgaatat aaccaactta ggaagaaggt gatcccatgc 3850321 caaataaaag taaacccaat agattaatcg ctgaaaagtc tccttattta ctccaacacg 3850381 cccacaaccc tgtggactgg ttcccgtggg gagaagaagc atttgcaaaa gcaaaacgcg 3850441 aaaacaagcc ggttctggtc agcatcggtt attcgacgac ttgtcattgg tggcctggga 3850501 taatcaaatc gtgtggaact ccattaaaag ataacagaag ccattttaaa cgataatact 3850561 atttgttcaa acaatacagt ctacctttta tttcattcat tttctaaaac ctgtaatccg 3850621 taaccacgcg gtagcaggtt tttttatttg cttgacttag agttaactct aaattgtaaa 3850681 ctaactttaa ttaaatgaga gggatgatgt tgttgtattc cattagtaaa gctgctgaga 3850741 agactagtat tagttcgtat acattaagat attacgaaaa gattgggtta cttccaccac 3850801 caaaacgaaa aaacagtgga aggcgttttt atacggagac tgatattcag ttcatgttat 3850861 tcctgaaaag tttaaaggaa acaggtatgt ctttggagga tattaatgag tttgtcaaag 3850921 acggatgcat tttggaaaaa atcaattcgg atgttaaatc ggcacaactc tccccatcta 3850981 taaataaacg tattgagatt ttaaccaagc acttagagaa aatggaaatt aaaaaaaggg 3851041 agctggaaga agtgatttct actacaaaag gaaaactgga tacatattat tcaattttga 3851101 aagaggaagt ggaaaacaaa tgaaacattt aaatatatac ataatgttac ttggcttctc 3851161 tattttcacg ggagctactt ttaatcttgc aaaatataca gttggatatt tttctccatc 3851221 gtcttctgcg gcatggcgtt tcggtttagc ggctgcagtg atgctcatca ttttgatttt 3851281 tactgaaggt ataaagaaga gtcaattacg gaaaaacgcc gtttcataca ttgttcttgg 3851341 aattatagga atctttggat ttaatgcctt gttttttgtt ggtttaaaat atacatctcc 3851401 cgttaacgga gcattaataa tggggctgaa tcctttatta acagcaattc tcgctcgaat 3851461 tatcttaaag gacaacatga caaaaaaaca agtactcggc atattctttg cattcatcgg 3851521 tgtattgtta gtcattacac aaggttctat cgaaaccatt aaaaccttat caatttcagg 3851581 aggagactta ataatcttta caggtaacgt ttgttgggca ctttatggcg tacttggacg 3851641 tcggtttgta aaggatggta caccgctatc tacaaccact tatacgatgg ttattggtgc 3851701 tgttagttta atagtagttt ccttatttac atccaaacct gtttctttat cgaacatccc 3851761 gattggagtt tggggggcaa ttgcttttat ggcttttttt acaagtgttt tgggttacct 3851821 atggtggaat caggggatta aagagattgg agctagtaaa acatctttat ttttcaacct 3851881 tgttcccgtt gtaacgatga ttatttcatt tgccgttgga acaccaataa aggtatttca 3851941 agttattggg gctgtgctag ttatattagg cgttttaacc gcttcggggg taatacgtat 3852001 tcctaagtac aatactaaag aacagtcagc tatataaaga aatagggagt atttttgaga 3852061 aaatgtgtta agttaaatat acactaatta taggaagaag gtgatcccat gccaaacaaa 3852121 agtaaaccca atagattaat caatgagaaa tcaccatatt tactccaaca cgcccacaac 3852181 cctgtggact ggttcccgtg gggagaagaa gcttttgaaa aagcaaaacg cgaaaacaag 3852241 ccggttctgg tcagcatcgg ttattcgact tgtcattggt gccacgtgat ggcccacgaa 3852301 agctttgaag acgaagaaat cgcgcgtctt ctcaatgaac ggtttgtggc gattaaagtc 3852361 gaccgggaag agcggcctga tgtggattct gtttatatga gaatctgcca gctgatgacc 3852421 gggcagggcg gctggccgct gaatgtgttt atcacgcctg atcaaaagcc gttttacgcg 3852481 ggtacatatt ttccaaagac gagcaaattc aatcgtcccg gttttgttga tgtgcttgag 3852541 catctgtctg agacgtttgc gaacgaccgc gagcatgtcg aggatattgc ggagaacgcc 3852601 gctaaacatt tgcagaccaa aacagctgca aaaactggtg agggccttag cgaatcagcg 3852661 attcaccgga cattccagca gcttgccagc gggtttgaca cgatctacgg cggtttcggg 3852721 caggcaccga aatttccaat gcctcatatg ctgatgtatt tgctacgtta tgatcacaat 3852781 acagggcagg agaacgctct atacaacgtg acgaaaacat tggacagcat ggcgaatggc 3852841 ggcatttacg atcatatcgg ctatgggttc gcccgctatt cgaccgatga cgagtggctc 3852901 gttccccact ttgaaaaaat gctgtacgac aatgcgctgc tgctgaccgc ttatacagaa 3852961 gcctatcagg tcacgcaaaa cagccgctat aaagagattt gtgagcagat cattacgttc 3853021 attcagaggg aaatgactca tgaagacgga agctttttct cggctttgga cgcggacaca 3853081 gaaggagaag aaggaaagta ctacgtgtgg tcaaaggaag agattctaaa aacgctcggg 3853141 gacgatctcg gaacgctgta ttgccaagtg tatgacatca ctgaagaagg aaactttgaa 3853201 ggcaaaaata ttcctaacct cattcacaca aagcgagaac aaatcaaaga ggatgccggg 3853261 ttaaccgaaa aagagctcag tctcaaactc gaagacgcaa gacagcagct cttgaagaca 3853321 cgcgaggaaa gaacctatcc gcatgtcgat gataaagtgc ttacctcatg gaacgcgctg 3853381 atgatcgcgg gtcttgcgaa agcggcaaag gtataccagg agccgaaata tctcagccta 3853441 gcgaaagacg ccatcacatt tattgaaaac aaattaatca tcgacggccg tgtgatggtc 3853501 cgatatcgtg atggcgaagt gaaaaacaaa ggctttatcg acgattacgc ttttctccta 3853561 tgggcttatc tggatctcta tgaagcttcg tttgatcttt cttatttaca aaaagcgaag 3853621 aaactgacag acgatatgat cagcttattt tgggatgagg agcatggcgg attctacttc 3853681 accggacacg atgcagaagc cttaatcgta cgggaaaaag aagtgtacga cggcgccgtg 3853741 ccttcaggaa acagtgtggc agctgttcag ctgctgcgtc tcgggcaagt cacaggcgac 3853801 ttatcactga tcgaaaaagc ggaaacaatg ttttccgtgt tcaagccaga catagaagcg 3853861 tatccgagcg gccatgcttt ctttatgcaa agtgtgttaa ggcatctgat gcctaaaaaa 3853921 gaaatcgtga tttttggcag cgcagacgat ccagccagaa aacaaattat agcggagctt 3853981 caaaaagcct ttaagcccaa cgactccatt ctggtggcag agcagcccga gcaatgcaaa 3854041 gacattgcgc catttgcagc agactaccgc atcatagacg gcaaaacaac cgtttatatt 3854101 tgtgaaaact tcgcctgcca gcaaccgaca acaaatattg aagaagcgat ccacacatta 3854161 ataagcagca gggattaaga cccttgctgc ttactttttg atttcttatg gtaccataaa 3854221 gcgatccccg caaacacaag gttgaccgct atcgtaaaga aagcctccca catcgggttc 3854281 ccccgcgtaa cggtaaacag agaaggaatt cctccataca cactgttttt ttctgtaata 3854341 aacatacaca aaaacatatt attcgcggca tgggcgccaa gtgatatttc gatgctccca 3854401 gttttaatcg tgtaatacgt ccacacaaac ccaaatgtta agtactcaat tcctgcccag 3854461 acagcgccat tgttcatttc tggattcgca aaatgcaata cgccaaacaa tcctccgaca 3854521 atcagtgtca aaaatagagg atttttcgtc aatctcccga aagcttgaag caaaaatccc 3854581 ctgaaaaata gttcctcagc tgatgtctga atcggaacca aaatgagggc agccgctagc 3854641 agccagataa atcgtgatgc attaaactct tgcattgaat agctatcagg atgaatcaca 3854701 aaatcaatca attgtacggc gatcattagc aagaaataag caataaaacc aaaggaaatt 3854761 ctccgccaat tcatctttga atttggtgtt atcaccgttc ggaaaggccg cttcaaaata 3854821 aagcgcacag ccagccaaac tcccggaatg gcgaataaat aaatcacatg ggacaaataa 3854881 agatctacga ggggatcact cagcacagct tcatccaaat caaacgtgat attgggattc 3854941 acaataaccg tgaacaatat agcgaaaagg taagctatat tccctaatac atataaccct 3855001 accatcacca aaaaagcgaa aaaatatctc cacaacgtat tgtttccttc tataggacgg 3855061 ataaatgaat tcattccttc tatgtctctt cctttcaatg agaatattac tatatatttg 3855121 cataaattgg tctatgaatc tactgttttg gaaatctttt aagcaaaatt aaaatataaa 3855181 gtgtgaattt agttcttcca tctagtgatt tgaactctgt tgccaatgaa ccaagatact 3855241 tataatagtc ccaagagggg aattttcagt cttttctact actcaaaagg gggtttttta 3855301 tgaatacgat cttcaaacaa aagaatacac atcctttctc aaacgcagcg aatcgtttag 3855361 accgccttcc gatttcacgc gttcatttcc aagtgttaac cgctctcggc attgtttatt 3855421 tctttgatct cgcagattta tttaccctca gcaacgtagc gccggcactg atcgagcatt 3855481 ggggcatccc gctttcaact attgctaacg taacggccgc ttcgttttta ggcatgtttt 3855541 taggcgcttc actgggcgga cggctgtccg atcgaatcgg ccgcaaaaaa gccttaaatc 3855601 tatttgtctt tgttttctca atcgcatcgc tatgcaatgc tgcggcatgg gacattccat 3855661 ctttaatgac attccgtttc ctcaccggat ttggcgttgc agccgccatg gtcattacga 3855721 atagctattt ggcggaattt ttcccttcaa gtgtacgtgg aaaatatatt tctttttgtg 3855781 ccatgattgg attgattggg gttccgatca ccaacattgt gtctgccttt gtcattcctc 3855841 ttggttcatg gggatggagg ctagtatttg tatggggtgc cgtcggcctt atttattttt 3855901 tcttcatcca ccgtctggaa gagtcacctc gctggcacga aaatcgcggg gaatatgcga 3855961 aagccgatgc gatcctcacc cgaattgaag aacaggttga aaaggagaaa ggcccgcttc 3856021 cggcagcatc ccagcctaaa gtaagcgaaa ctgttaagca gaatgcaggt tacgcaggct 3856081 tattgaaagg cagaaacctc aaaattacca tcgtattatc tgctgtatgg atttttgaaa 3856141 cgtttgggtt ttacggattt gcttcatggg ttccaagcct gctaaaaagc aatggcgtaa 3856201 ccatggaaaa tacattatgg tataacgtat tgcattccgt cggcgctcca cttggcgcac 3856261 tgctcggctc catgatttcc gaaagatttc aaagaaaatg gattttagct gcgagtgcgt 3856321 ttctgacggc catcgccggg ctcttatatg gtatgacttt tattcccatc atgatcattg 3856381 tatttggttt tatcgtgaat atcacagaac gggtctttac ctcgaactta tacgcctata 3856441 catctgaacc ttatccgact gaataccgct cgtctggcag cggtttagcc tatggtcttg 3856501 gccgtttttc aaacattttt ggctcattgc ttgtcggatt tattgccgtt cagctcggct 3856561 atatcagcgt cttcttattt attgggggct gttggctcgc atgctccttg ctgttaatct 3856621 tcttcggtcc taatacgaat gcaaaacaga tttaaaaaag tcagtgcgga tctgccgcac 3856681 tgatctcatt acaattgctt caaaatcctt gcggggtttc cgcctacaac agtattagcg 3856741 ggtacatcct tagtgacaac agatccagaa gcaatcactg cgttatcacc gattgtcact 3856801 cccgggttaa tcaccgcccg gcctccaatc caaacttgat ctccaattgt cacaggctta 3856861 ccgaactcct tcccggattt cctttcgatc ggatcaagag gatgaccggc cgtgtagata 3856921 tgtacacctg gcgcaatcaa acaatgacag ccgatacgca cctcacacac atctaaaatg 3856981 acacagtcaa aattaacaaa tgtatgatct ccgatatgaa tgtgatagcc ataatcacag 3857041 cggaatgtcg gcaaaatcgt gacttgatcc ccaaccgaac cgagcagctc cttcaaaagc 3857101 ttcgtccgca ctgcatcatc ttccggtgtt tcgttgtatt gtctaatcag ctgtctcgca 3857161 tgcttgcgtt ctagtaatag ttgttgatct tccgaattgt ataattctcc ggctgccatt 3857221 ttttcttttt ctgtcctcag catttaagtc actccagatg tcagattgta atctcgatca 3857281 aatttccttc atcatcctca atcacgcttt catagtagcc gtctcctgtt gtcctcgggc 3857341 cgtttactac tgcgaaacca tccgccttca atcgatcagt cagttcgtca actttctccc 3857401 ggctcccaac ggaaaaggca atatgtgccc agcctgtcat tgtttgtgag ggcggatcgg 3857461 tcacattccc ttttttcata atttccagcc ttgctccgga atcaaacgta ataaaataag 3857521 acttaaaatc ttttttctca ttatgataca aatcattcgc ttcgccatta aaatacgatt 3857581 cataaaaaga cttcattcgc tctaaatcat tgacccagac cgctgtatgt tcaatctgca 3857641 tttcttcctc ctccttcgcc ttcaatgaag ttataaggta tgaaatgcat ttcagttcaa 3857701 gcttttttct taaatttatg ctgaattttg atatcagcgg gttcatcctg caaaaataga 3857761 gaaaatgctg cgatgccgag ctgctcaaga ttcaaatcaa gcgacggaaa accaagaaca 3857821 cggctgatag aagtatttcc ctcgcctatg atttcaacat cccaattatt ctttttggca 3857881 aatagatgaa ttccagctgc cacttcatca ctatttgcat aaatagcagt cggaacccgc 3857941 ccgctcatat aaaaatgttc agctgccagc tcaccatcat tcatatcgtt gcatccggac 3858001 agcatatggc ggtcttccaa ccttccgcag acagctttat aggccgcagc tttatcagcc 3858061 gtgctcgggc tcctatcagc ttctctgaca cacgtaaaag caatattctc atgcccgcgg 3858121 ctctttaaat agcgaaagct ctctgcataa gcagtttttc tgtcattaaa agcacaaggg 3858181 acatcaatgt ctccggtatc ctcacaagcg atgaccggcc catattcctg ataagctaaa 3858241 atgctgtccc aatgattggc gcgggaagta atgatgagac cgtctatttt cttcgttctt 3858301 aacagctcta aatatttgat ttcaatatcg gggttataat tggtggggag aagggtcgtt 3858361 gcatactcat gctgaaaagc cgccttggtg attccgttaa cgattttatc aaagcaggga 3858421 tgatcgctat aaggcagaat cacaccgacc gtatgggttt tcccgcgaat gagatcgatt 3858481 gcggttcgat ttggtgtata atccaattcc ttcatgactt gatgaacaag ctttctcttt 3858541 tcttcagata catacggatg atgattcaat acacgcgaga cagtcgaaac agatacattt 3858601 gccagtcttg cgatctcttt tatatttgcc atctctttct ccttttcata taaaaaaagc 3858661 agtaagtgta aaatccttac tgctatctca tcatatattg atgataagtt caacaggaca 3858721 atggtcggaa cccatgacgt ccgctgatat gctggcatct tcaatctgtt ccttaaggct 3858781 ttcagaaaca acaaaataat caatccgcca tccaatattt ctgtcccggg cgccggcacg 3858841 atacgaccac caggaataag cgccttcaag atcaggataa acatgacgaa aagaatcaac 3858901 aaagccagct tctaagaaac gagtgaatgc ctctctttct tgatctgaaa atccagcgtt 3858961 attccggttc gcctttggat ttttcaagtc aatctcctga tgggctacat tcaaatcacc 3859021 gcataaaatc actggttttt tctgatccaa ttcaagaata taagacagta aagcctcttc 3859081 ccattgcatg cggtaatcaa tccgctctaa tccccttctg gaattgggcg tgtaaacagt 3859141 catcacaaac acgttttcaa attccagcgt aatcactctg ccttcttggt catgctcttc 3859201 tactccgata ccgtagatga cctgcagcgg ttcttgctta gaaaaaacag ctgtgccgga 3859261 atatcctttt ttcactgcat aattccagta cacatgatag tcttcaggct ggagatcaac 3859321 ctggccgtcc tgtatcttcg tttcctgaag acatataata tctgcatcct cttctttcaa 3859381 ataagagagg aaatccattt ttctcatcac agcccgcagg ccgtttacat tccatgaaat 3859441 caacttcatg tttcatcctc ccccctataa aaaagagcaa gaacccgaag gtccttgctc 3859501 tttacatatc agcttactca ccgcttacgt atggaagtaa agccatttga cgtgcgcgtt 3859561 tgatcgctgc agtcaattta cgttggtatt tagcgtttgt tccagttaca cgacgtggta 3859621 aaattttacc gcgctcagaa acaaactttt taagaagatc tacatctttg tagtcgatgt 3859681 gcgtgatacc gttagaagtg aaataacaca ctttacggcg tttcgcacga ccgcctctgc 3859741 gtcctcctgc cattgtcatt tccctccttt ctttttcatt ttaggcgata atcacattag 3859801 aatggaagat catcatccga gatgtcaatc ggtttgccgt cgttggcaaa tgggtcatca 3859861 ttaaagctgt tcccctgatt gcgtctctgg ttgttttgat ttcccccaaa tggattatca 3859921 ttttggcctc cgccaaagta ctggcctccg ccgctgtttc cttcgttgta tccacctgaa 3859981 ccagaaccgc cgccgttttt cggctcaaga aattgaacac tttcagcttg gacctctgtc 3860041 acgaagacac gctgtccttg ctggttttca tagtttcttg tttgtaaacg gccatctacg 3860101 cctgcaaggc ttcctttttt caagaagttt gcaacgtttt cggcttgtct tctccaagtg 3860161 acacaattaa tgaaatcggc ctcacgttct ccggactggt tcgtaaatgt acgattcaca 3860221 gcaagagtaa acgtagcaac agccgcaccg tttggcgtat aacgaagctc tgggtctttt 3860281 gtcagtcttc cgactaatac aactcggtta agcataagaa agaccacctt ttaccattat 3860341 atatttcaaa attgcttatt cttcttcttt aacaacaatg tggcgaatga tatcgtcact 3860401 gatcttagct agacggtcaa attcttgaac tgccgcagcg tcagattgaa cgtttacgat 3860461 ttggtagaaa ccgtcgcgga aatcgttgat ttcgtaagca agacgacgtt taccccaatc 3860521 ctttgttcca gtgatctccg caccgttaga agtcagaacg ttgttgaaac gctcgataac 3860581 tgctttttta gactcttcgt caatgtttgg gcggataatg tacataactt cgtactttct 3860641 catctgtttg cacctccttt tggactaagc ggcccataat gggcaaggag caataattct 3860701 attactcaca attttatatt ataccaaagc tcttgtccct ttacaactgc atcctataca 3860761 ttaaatcgga aatgaataac atctccgtct tggaccacat attctttccc ttcaaggcgg 3860821 acttttcctg cctctttagc tcctgccata ccgccgcccg caagaagatc ctcataagca 3860881 actgtctcag cacgaatgaa gccccgctca aagtcactat gaataattcc tgcacactca 3860941 ggggctttca tgcctttttt gaatgtccaa gctctgactt cctgttctcc ggctgtgaaa 3861001 tatgttgcga ggccgagaag agagtaagac gctttgatca gctgatcaag acctgattct 3861061 tgaatgccca gctcttccaa gaacatttgc ttttcttcgc cttcaagctc agcgatttca 3861121 gattcgattt ttgcacacac aacgataact tctgcgtttt cgccggcagc gtactcgcga 3861181 atcttcgcta cattttcatt gccagatgga tcagcaactt catcttcact tacgttggcc 3861241 acgtacaaaa taggcttcga agtcagtaaa tggagctgct tcacaagctt ttgctgctct 3861301 tcagtgaatt ctacagatcg agcaggcttt tcactctcaa acgcttcttt cagtttagat 3861361 aaaatctcaa actcaaatac agcgtcttta tctttttgct tcgcaagctt gctgacgcgt 3861421 gtaatccgct tttcaactgt ttccatatca gcgaggatca gctcaaggtt gatcgtttca 3861481 atgtcatcaa tcggatcaac ctttccggaa acgtgtgtaa tgttgtcatc ggaaaaagca 3861541 cggacaacgt ggcaaatcgc gtcaacttgg cgaatatgag ataggaactt gttgccgagt 3861601 ccttctcctt tagatgcgcc ctttacaatc cctgcaatat cagtgaattc aaaagcagtc 3861661 ggcacagtct tcttcgggtt gaccagctca gtcagctttt gcagacgatc atccggcacc 3861721 tctacaattc ccacgttcgg atcaattgta cagaacgggt agttggctga ttcggcaccg 3861781 gcctgtgtaa ttgcgttaaa tagtgttgat tttccgacgt tcggcaaacc aacaattcca 3861841 gctgttaaag ccattctttc atctcctcta tataaaaccg tcattgtatg aacgtatttt 3861901 gaacctagag caattataag gaggttcact ggaaaagaca agctgacaaa aaagcatttt 3861961 cagcttgcca atccctttga ttatgctttt ttcaagccta ctaaacagtc aaaaagcgta 3862021 cttcccattc cattatcaga atttgtatca tttgtcagtg cattgactga ccctccaaaa 3862081 gccgcccaca tgccttcatc tatattaatc gtcttcgcat gagcctgctt catcactttc 3862141 accttgccct tcatgcttcc gcggtcatta aagatgacaa cttcgtctcc atcctgaaga 3862201 tcctgcccag ccgctatatc tggagaaata tcgacctgaa cgtgctgaag cttttcaata 3862261 aacggcacat gctgtgaatg attggaacgc tgcggatgaa tggataagag cgtataaggg 3862321 tactttccag ctaactcctc attatggaaa acagattctt cgggcacatt taattgaagc 3862381 gagccgctaa atcctttttg ctcagctagc gacgaagtaa attcaaattt tccactcggc 3862441 gtcaaaaact gataatcatc ccacggcacc tgttttactg gaagagggag gtggcctttt 3862501 tcttttaaac gctcaagtgt cacatcctct gcttccaatg aagaaagccc catctctaaa 3862561 aattcttgag tgctgtattc aaacagctcg ccaaacccaa gacgttttgc aagctctgac 3862621 cagatccagc tgtccgattt cgcttcaccc tgcggctcca caagcttctt cccgtactga 3862681 acataatgat gatacatact ggaatagtag atatcttctt cttcaaaaac agtggcagtc 3862741 ggcaaaacat aatcacacag ctctgcggta tccgtcataa tggaatcaat cgcgaccgtc 3862801 attggaacct tttcaaatgc ttgtctcacc ttatttgtat tcggcacctg agtcagcgga 3862861 tttccgcacg tcacaataat catctcaatc gcaggatcag cagcggtcaa cacttcttca 3862921 gcctgtgtca tcattgaaaa agaacgggat gttgttttta attccggcag cgtcagcttt 3862981 gtttttgcaa agctctcacc aatctggaca tttccgaaat tcgcgccgcc gcccttaatt 3863041 ccgacatttc cgcttgccgc cacaagtgca tcaatccaac gaatcgttcc cccgccgttt 3863101 ttatatcgct gcatgccaag ccccataaaa gtagacaccg gaccatcagc atacaaacct 3863161 gccaaatact ccagctcctc catagaagtt tctgttttca caataaactc ttccagagaa 3863221 acggtcttca aaagctcttt cacatcatca aaaccgacag aatgctcaga aataaacgtt 3863281 tcatccgttc ttcccatctc aatcagaacc ttcaaaacgg ctgccgcaag ccagccgtcc 3863341 attccaggct ttacagagat atagcggtcg gcaagcttag cagtcgggtt gaagatcgga 3863401 tcaatcaccg taatcgtggc gcccttcttt ttcacctgct gcaagtgatg gtataagtgc 3863461 atatttgttc ttgatacatt tcttccccac acaacaacat gcttgctgtt gtaaatatca 3863521 agcggtccgt gaccgtacga acggccaaaa tcccagcttt gcgcctcgat accggagccc 3863581 cagcatatgc ttccgacgat ttcggtcacg ccgccatatc cattaaaaaa acgctgatca 3863641 agcgctttta acagaccgtt attcgcataa tcatggctgt gcaaaacagc agtcgtctcc 3863701 gacgtttcct tgatttcccg aagtttatcg gcaatttcat caagtgcctg ctcccaagaa 3863761 atccgcacaa actcgccatt ttgttttttc attggatagc gaagccgatc aggcgaattt 3863821 gtttttgtct caagcattct gccgcggccg cagattttac cttccgtaat cggatggttt 3863881 ggatctccgt ccacttttgt tacctttcca tcatcaacag tcaccaaaaa gccgcagctg 3863941 tcccaacaat tcagcggaca tgccgactga tgcactttgc tcatcgccgt cttctcctta 3864001 ccttctatat gaaaaagcat gagtgtcggc ctatttatga agtaggctcc tcatgcttga 3864061 ctagtacttt ttttagtttt ctttcaaatt ctcttctcgg aatcataaca ctgtgagagc 3864121 atccctcaca cttaattcga atatccattc ccatgcgtat aattttccag ctgttcgctc 3864181 cgcatggatg cggttttttc atttctacga tatcattcag gccaaagtct ttatccgcca 3864241 agacccttca cctcttttcc taaactgctg tatctattgt acaaaaaaac tgatcataag 3864301 agcaatcaag atacccgaaa agaaatacat cctcttattt ccatttactc aaaataggat 3864361 ataagagcag acaaactaac aaatacaaat tgagcatccc atatatcgga tacaagaacg 3864421 cgatcaaatc agaaaatccg aaagaagtaa aaggtaccat taacactaac aaaatcaaca 3864481 caatcatcca tctcggcata tgaataaacg ccatcagccg gctggacaaa cccagcaaac 3864541 cagctaccgt cgtcgtgtaa atcgccaggc acagcaccgc cgtcatacat aaaaaaagga 3864601 aataaggcgc accctccaga acggcaaaca gcggtatttc aaactgagaa agggagcccg 3864661 ccagctccac caacgtttca ttataaacaa atgagatcac gccaaaaata agaccgcttg 3864721 ccacacttgc gatttttgct tctccgagcc ctttcatctc tttcccaaca gaggataaaa 3864781 tcgcaacaac tgaaaggatg tttaaagagg taaacgtaat gctcgcaggc cagttatact 3864841 gctgggacaa atcaatcgtc cacgtatggt gatgtgtgct ctgaaaggag atcagcgcat 3864901 ataaaagccc cgctactaac acaggaatca aaatactatt tatagataat attcctttca 3864961 catcccacaa aaacaagcac actgtcacga tgcaaatcag cgtgattccc caccagaaag 3865021 gaagcttgta catttgcagg gtcacaccgc ctccggcaat catcaccata gtcgtcgaaa 3865081 acaaataaaa aatgatgagg acatcataaa ttttcgccag ccatggcccc attaaatgct 3865141 ccagaaccgg cagaaaatga gtggattgaa ccttaaaact gattttcatc acaatataag 3865201 acgagaaaat gaacataatt gtaaacagca caatagcaag tccgctttcc gccccaaaaa 3865261 actgccatat ctcctgaccg ctcgcatatc cggccccgat caggctccct aatatgagca 3865321 gcatccactt cattccggct ctccacaaca ctatcacctc atagacaaag ttcagcttgt 3865381 tcccgttatt gttactatat aaataaagga aagcaaacat gccatatttt catagacatt 3865441 tgaacacaag ctgaaattat catacgaaat acacataaaa aagactgcta atacggcagt 3865501 ctaaaaagag atatttattt gtttgtccgc ggaatgaaga agtgaacttc actcttcact 3865561 tttttctaac cattcctacc tattcaagtg tttcataagc agaccattgc ttgatcatga 3865621 tcgaggcaat gggggacaat acttgtaatc gcccactaac cattcatatc atgccctcta 3865681 cttttttaaa atctctggtg ccatacacaa agcataaaaa atcatactgc tggatatact 3865741 gtaaacaacc ttacataact acacacacca tagcaattct gttacctact ataacaagga 3865801 agtgaaaccc atgaatcgaa aaggcgggct tttttcttct caggaacgag taaagcaata 3865861 tgtttcacat acagatgctg cagcggcaaa acaaatccaa accatccttt cttcatcctt 3865921 acgtaaagct gctggcaaac caattgtcgt ggtttgtatc ggaacagacc gttcaaccgg 3865981 tgactcatta ggcccgctcg taggaatgaa actcaaacag atgcagctca ccagattcca 3866041 tgtctacgga accttatctg accccgtcca tgctgtgaac atgaaggata aaatcaatga 3866101 cattcataaa ttacataaaa acccatttgt tatagcagtc gatgcatgct taggccgcgt 3866161 taagagtgtg ggttcatttc aaatcgggga cgggccatta aagcccggag ccggtgtaca 3866221 aaaagacctt cctgaagtgg gagatcttca tattaacgga atcgtgaatg tgagcggttt 3866281 tatggaatat tttgtattgc aaaatactag actcaacttg gtcatgaata tggcaaatgt 3866341 tctagcggaa ggtttgagtt taacagatcg gacagagtgg aggcaagaac gccttaaccc 3866401 gttgcaaagg ctcactgggc gcatataaaa taaaaaccat cttcgtttga aagatggttt 3866461 tttcatttat gattctcgtt cagacaaaag ctctaaaatc cggtcaaggt cttcattaga 3866521 gaaaaattca atttcgattt tgcctttttt cttctgtctt ttaatattaa ctgttgttcc 3866581 aaaataattt tggagatagg attcccgttc ttttagaacc gcatctttca caggttcttt 3866641 tttctttgtt tcacgtggaa cattctgatt caactgctga atcagctgct caagttggcg 3866701 aacattgagc tgctccgcaa tcactttttg taccagcggt tcaagcttat ttttgttttt 3866761 taagccaaga agcgtgcgtc catgtcccat agaaagcgtg ccttcggcaa taagctgttg 3866821 aatattttct ggcagtgtca gcagtcttaa atgattcgca atatgcggtc tgcttttccc 3866881 aagacgtttg gcaagctgct cttgtgtgag atctaagtgt ttcaaaaggg agtcatatgc 3866941 ctgagcctct tcaagcggag ataaatcttc acgctgaagg ttttctaata aagcaatttc 3867001 cctcattaac gcctctgata attcacggac aatggccgga actgtatcta aacctgccag 3867061 ctttgccgct cgaaaacgcc gttcacccgc aacaatatca tagcctttta aagattttct 3867121 gacgataagc ggctgaagaa tgccatgctg cagcacagat tcttttagtt cagctaatgc 3867181 ctcgtcatca aagtgttttc ttggctgata aggattaggg cgtaaatcgg caattttaat 3867241 ttcttcaact gtctcttcag acaaatctac ctgattaaat aacgcattaa tcccttttcc 3867301 aaggccttta gccattcgca gccacttcct ttgctaaatc taaatatact tccgcacctc 3867361 ttgaccgcgg atcgtataaa atgatgggtt ttccgtgact cggtgcctca ctcagacgga 3867421 cattacgcgg aataactgtc ttatatactt tatccctaaa atacttttta acctcttcaa 3867481 tcacttgaat gccaaggttt gtccgggcat caagcattgt cagcaataca ccttcaatca 3867541 ttaaatcagt attcaaatgc ttttgcacaa gacgtactgt atttaataac tggctgagac 3867601 cctccaaggc ataatattcg cactgtacag gaatcacaac ggaatccgag gcagtaaggg 3867661 cattaatcgt cagcaagccc aatgacggcg gacaatcaat gataatataa tcataatttt 3867721 gctttactgc ttcaagcgct ctcttcaatc tcacttctct tgatattgta ggaaccagct 3867781 cgatctcagc ccctgcaagc tgaatcgtcg caggaatcac atccaagttc tctactgtcg 3867841 ttgctttaat aatatctatt acatctgcat catctactaa aatatcgtac acacactgct 3867901 ctacatcggc tttttcaatc cctaatccgc ttgtcgcatt tccctgcgga tcaatatcta 3867961 ccagcagaac ccttttccct atgtaagcca aacatgcccc aaggttgaca gacgtcgttg 3868021 ttttgccgac cccgcctttt tggttcgtaa ttgctatgat ttttcccacg atgtcaccta 3868081 ctttcacatg aacatgtact atcttgcttc tattctatca aaaaaagatt aaagcgtttc 3868141 atttttttca tcattttgtt ccgaatcaga agggaaataa ttgaaaattc aagcacgctt 3868201 tatgctttct cttataaatt ctgcaatttc tatgtttttt tgacttaaaa aaggaatttc 3868261 ttaaagaaaa aaagaagaag tcacagtaca gaacgtggaa acaggatggt gagaaaatgg 3868321 tttatcaaac gaagagagat gtacccgtta cgctgatgat tgtgtttctc atattactga 3868381 tacaagcaga tgccattgtt ccttttgtgc tgggaaatat gagagtttcc ggctggatca 3868441 tttttattct gctgactctt ttaaatggac tcatcatttg gagctttatt gacctaaaat 3868501 atgtattgaa ggaacaccat ctgatcatta aagccggatt gatcaaacat caaattcctt 3868561 atgaaaacat cgataaagtc gttcaaaaaa agaaactatg gtccggtttt cgtctgatcg 3868621 gctctcgcca tgccatcaca atatattatc aggggggatg gggacatgca gtaatttcac 3868681 cgcaaaaatc tgaagaattt atccacaagc tcaaagaaaa gaattctaat ataataatat 3868741 tcactaaaag taagtgatta ccttttgtta aaaatataaa aagctctcct gcttttcagg 3868801 agagcttcta ttttggtatg cgaatcgtta attgaatata ttcttcaaat tcttcttctt 3868861 ccgtattcaa ttttacaccg ctgtcttcca ccattgatag tgactggcga atcgtgttca 3868921 tcgcaattct tgtatctctg ctgaatgctt tgcgtctcgg ctttggcttt ctctggcctt 3868981 gctccagcat tttcaccacg cggtcttctg tctgctttac atttaaactt ttctcaataa 3869041 tctctgtgag cagtgtgact tggagctcag gctgtttcag cggaatcagt gctctggcat 3869101 ggcgctcggt gattttcttc tccataatcg cctcttggac cggctgaggc agctttaata 3869161 accgaagctt attcgcgatt gtagactgcc cttttcctaa gcgctgtgcg agtgcctcct 3869221 gtgttaaatc atgcagctca agcagcctag cataagcatg cgcttcctca atagaagaca 3869281 gttcttcccg ctgcaagttt tcgattaacg ccacagaagc ggtttccgtg tcggaaaaat 3869341 ccttaataat tgccggaatc ttttcccact caagcgattg caccgctctc cagcgtcttt 3869401 cacctgcaat gagttcgtat tggccttctt cttctgtatg cctaacaaca atcggctgaa 3869461 taatgccgtg tgtatgaatg gtcattgcta actctttgat tttttcatct gagaaaatgg 3869521 tgcgtggctg aaaacggttg ggaacgatag catttaccgg tatttccaga atctcttctt 3869581 tgtttgtatc atgttcagca atctccggct cctgttcctt ctcaccaagc ccgaagaaac 3869641 gagagaatga atgcttcatg tacctacacc acctttaaaa actgccattt ttataattct 3869701 attttctcat ggtttttcct gctgtacatc catcaatttt gatgaaaata tgatggtatt 3869761 gtcatatcag gctgtctaaa ttacccttca attggcgatt tattaggagt tcccggtttt 3869821 cttggatact tcttaggtgt attttttatt ttgcgtatca ccataatatt acgatcgctt 3869881 tcttcaatag gcagcttaaa agaatggata ttctcaagtt ctcctccaag cgtcgtgatt 3869941 gcttttttgc ctgcattcag ttcttcttca gctgatgcgg cttttaaagc aacaaataaa 3870001 ccgtttttct tcaccagagg caagcaaagc tcactcaaaa cagataatct cgcaactgcg 3870061 cgcgccgtca caatatcata gctttcacgc acgtctttcc gttgcccgaa cgtttcagct 3870121 ctgtcatggc agaatgttgt attctccaat tgcaaagctt cagacaactt ttctaaaaac 3870181 gtaatccgtt tgtttagtga atccacgatt gtgacatgga ggtgcggaaa gcatattttt 3870241 atcggcagac ttggaaaacc cgctcccgct ccaacatcac aaatcgtgtt cacctgattg 3870301 aagtcgacat aaaaagcagc tgtaatggaa tcataaaaat gctttaaata cacttctttt 3870361 ttctctgtta ttgaagtcag attgattttt tcgttccatt caaccagcat gtcgtaatac 3870421 agctcaaatt gctccagctg acggggagaa agggagatcc ctttttccgc caaaccagaa 3870481 gtgaattctt caatattcat gccgtcatcc tttctactcg gctatcttcg caatgcgtcc 3870541 ctgctctaaa tacaccaata gaattgaaat gtccgccggg tttacaccgg aaatgcggga 3870601 agcctgggca acagacaaag gccgtacatt tttcagtttt tgacgcgcct cggtcgcaat 3870661 ccccttaatt gcgtcataat caattcggtc tggaattttt ttattttcca tcttcttcag 3870721 tttttccact tgctgaagag atttttcaat atatccttca tatttcactt ggatttctac 3870781 ttgttctgcc acgtcttgag gaaccggcac ttctggcggc gccagttttg tgactgtttc 3870841 atagttcatt tcaggacgtt tcatcaagtc tgtgccgcga actccatctt tcaattcgct 3870901 tccgccaaga gaacggatat attcttgatt ttccggagac ggcttgataa ttacagaatg 3870961 aagacgtttt ttctccgcct cgatcgccgc ttttttcttc tcaaaagccg catagcgctc 3871021 atcagaaatc aatccaatgc gatgtccgat ttctgtcaga cgcaaatcag cattgtcatg 3871081 gcgaagcagc aatctgtatt ccgcacgtga tgtcaaaaga cgatatggct cattggtacc 3871141 ttttgtcaca aggtcatcaa tcagaacacc aatataggcg tcagaacggc ttagaattac 3871201 ttcttctttt ccaagcgctt ttcgtcctgc attgattccc gccataatcc cttgtcccgc 3871261 agcttcttca taaccggatg ttccgttaat ttggcctgca gtataaaggt ttgtgatttt 3871321 tttggtttca agtgtcggcc atagctgtgt cggtacgatt gcatcatact cgatcgcata 3871381 gccggctctc atcatttgca cgttttcaag tccaggaatc gttgcaagca ttctttgctg 3871441 tacgtcttct ggaagacttg tagataaacc ttggacatag acttcctgtg tatttctgcc 3871501 ttccggctca aggaagattt ggtgacgcgg tttatcatta aaacggacaa ctttgtcttc 3871561 aatggatggg cagtatcttg ggcccgtacc tttgatcata ccggaataca tcggtgaacg 3871621 gtgcaggttg ctgtcaataa tctcatgtgt ctcagggctt gtatatgtca gccagcaagg 3871681 gagctgatct gtgatatatt ccactgtttc atatgagaaa gcgcgaggca catcgtcacc 3871741 aggctgaatt tccgttttgc tgtaatcaat cgtgtcgctt ttaacgcgag gcggcgtacc 3871801 tgttttaaaa cgaacaaggt caaaaccgag ttcctccaaa tgctcagaaa gcttaataga 3871861 aggctgctgg ttattcgggc cgcttgagta agacagatcg ccaagaatga tacgtcctct 3871921 taaatatgtc cctgtcgtca tgacaactgc tttcgcacga taatgtgcgc ctgtttgtgt 3871981 aataacgcct cggcattcgc cgtcttcaac gatcagccgc tccacaattc cttgcagcaa 3872041 tgttaagttt ggttcttttt caagcgtatt tttcatttcg tgctgatatt ggaatttgtc 3872101 tgcttgcgca cgcaatgcac gaaccgcagg accttttcct gtattcagca ttctcatttg 3872161 aatatgtgtt ttatcgatgt ttcttcccat ttctccgccg agcgcgtcaa tttcgcggac 3872221 gacaatccct tttgcggggc cgccgacaga cggattacat ggcataaatg caaccatatc 3872281 taggttgatg gtcaagacaa gcgttttggc gccttggcgt gcagatgcga gggcagcctc 3872341 aacaccggca tgcccggcgc caatcacaat cacatcgtat tggcctgctt cataccccat 3872401 gattctagtt cctcctttaa ttattttcct aaacagaatt gagaaaagag ctgatcaatt 3872461 aagctttcgt ggacagaatc tccaatgatt tcccctaaaa gctcccagca tcttgtaagg 3872521 tcaatttgca ccatgtcgat cgggacatcc tgttcgatgc cgctaagcgc atcttcaatg 3872581 gcgcgttttg cttgctgtaa aatagtgatg tgacgtgtgt tgctgacata agtcagatca 3872641 ccgctttcaa tggcacccgt gtagaacagt gattgaatcg cttcttccag atcattgatg 3872701 ccttcctctt ttaaaagaga tgtcgtaaca actggacgtc cattggcaag ctcacggaca 3872761 cgttcagtgt caatcttcgg ctcaaggtca gtcttattca aaatcacgat aacatccatg 3872821 ccctcaacgg cttcaaaaag cttcacgtct tcttcagaaa gctcttcact ataattaagc 3872881 acaagtaaaa tcaggtccgc ttcctttagg acctggcgag aacgttcaac accgattcgc 3872941 tcaacaatat cctctgtttc acgaatacct gctgtatcaa ccagacgaag cggaacgccc 3873001 cttacattca cgtattcctc aatcacatcc cgtgtcgttc cgggaatatc ggttacaatg 3873061 gcttttgcct catgaacgag gctgttcaga agagatgatt ttcctacgtt tggccggccg 3873121 ataatgacgg tagaaagacc ttcacgcaag atttttcctt gctcagaagt cctcagcagc 3873181 gtctcaattt cctttttcac ggcggttgcc ttttcgacta aaatctgatg cgtcatttcc 3873241 tctacatcat catactccgg ataatcaata ttcacctcaa catgggccag tgtttctaaa 3873301 atctcactgc gcaaacggcg caccaaagca gaaagacgcc cttccatttg attcatagca 3873361 acgttcattg cccggtccgt tttcgctctg attaagtcca taaccgcttc cgcctgtgaa 3873421 agatcgattc ggccgtttaa aaacgcacgt ttcgtaaatt caccaggctc tgccagtctc 3873481 gctccctctc tcaatgcaag ctgaagcact tggttcacag tcacaattcc cccgtgacag 3873541 ttaatctcga tgacatcttc tcgtgtaaaa gttctcggcg cttttaacac tgataccatt 3873601 acttcctcaa cgacacgatc cgaaggtctg tctacgatat gaccataatg aatcgtatgt 3873661 gattcgaccg agctgagtgt tttccccttc ggtcccttat aaattttatc tgcgatttga 3873721 atggcttctg gtccgctcaa ccgtacaatc gcaatcgcgc cttctcccat cggtgtggaa 3873781 attgccgcaa ttgtatccat gttgttcacc tctctttact tatacttcat ctatataaaa 3873841 aaatttttat tatgccaaaa ctaaaagata acatagtttg gttcgaagtg gaagatttgt 3873901 tatccacaga aatagaaatt cgtcccttat tactttaact tatccacatg tgaataacaa 3873961 ttaattttat ttcctgaact tcctttttat caacaggata cacctaaaaa gaaaaaactt 3874021 aaacggcaaa accttgatat tactaggaaa agtagatttt tcggatacaa aaaaaccgaa 3874081 atccaatttt tatcggactt cggttttatg ctatctttta tgggaaataa cgagatgacg 3874141 attttcgcct tcacccattg aatatgtttt gatctggtgg tttgcatatc cagaaagagt 3874201 atcgtgaata atttttcttt cgctggacgg catgggctca agctggatgg attttttcgt 3874261 tttcaaaacc tggtcagcaa gcttgatggc cagctggctc agtgtttctt ttcttttcaa 3874321 acgatagttt tctgcatcca ccgtcacatt tttatattgg cctggataac ggttaagggc 3874381 aagctgtgtc aaagtttcaa gggcgtttaa agtttgtcct cttttcccaa tcaacaatgc 3874441 tgccttttca cctgttatat gatatctcac tgtctttttg ctttcttgaa cagtcacatc 3874501 agacttcccg gcaatggctt cggcaatcgt ttgaagatat aacttcgctt gctgaatcgg 3874561 atcaatcttt tcaaccagct ttacgatcgc aggcttttta ccgaaaatac cgagaaaccc 3874621 tttgtttccc tcttcaataa cagtaatttc taccttatcc ttcgttaatc ccaactcttg 3874681 caatccggac tgtactgctt catcgacatt tcgccctgca gcagtcacat tcctcacttt 3874741 ttctttcctc cggctttttg cggctcagga ttttttttaa tatcaggtcc tttaatgagg 3874801 aaagtttgcg caatcataaa caagttacca actacccaat aaagagaaag agccgccggg 3874861 aagttgatcg caaatacgat aatcataatt ggcataatcc aaagcatcat cgccatttgc 3874921 ggattttgct gcgcattgcc agccatcatc agtttttgct gaacaaatgt agcgacaccg 3874981 gcaacgatag gaagaatata gtaaggatct ttttctccta agtcaaacca taagaagcta 3875041 tgctctgaaa tcgcctgggt tctcatgatc gcatgataga atccaattaa aatcggcatc 3875101 tggatcaaaa tcgggaaaca tcccgccaat ggattgacac catgcttttg gaataaagcc 3875161 attgtttcct gttgaagctt ttgctgcgtt ttttgatcct ttgagctgta tttttcttta 3875221 agcttttgca tttccggctg taaagcctgc atcgctttcg aacttctcag ctgcttaatc 3875281 atcagcggta aaattaataa acgaattaaa atggtaacta gaataattga aagcccgtag 3875341 ttatctcccg tcaatttcgc tacatacgta atgagctcag acaatggata tactacgtac 3875401 ttgtcccaga aatgcggact atctgcagtg atcggctctt tcacactcga gcatccagcc 3875461 aaaagcatga atacgccaac catacttaat agcaacccta ttctcctttt caacaacatt 3875521 tcctcctata attaatcttt acactctttt attgcaaagc atacttgtat gtattttagc 3875581 atctttcagt tttaaatggt gtctttttct gatcaaccag aaaggaagcg cttttaaaag 3875641 ttgtaagaaa gcagtggtga tgcctacttt gacgaagatt tcttatataa tgaagacttt 3875701 ctgaatagat gctgcagact ttttttcgtt tcctcatatg tcagctggct cgccggtttt 3875761 ctggcaataa tgatgtaatc cttttccttc agtctctctt tctcttcaag aaaggcctgc 3875821 cgaatcaaac gtttgatccg atttcgcatc acagcattgc caattttttt gctgacggaa 3875881 agcccgacac gcagttcatc attttcaggc tgatcaagcg tatataagac aaactggcgg 3875941 tttgcaactg atgtcccatg tttaaacact ttttgaaaat cttcattttt ctttaaacga 3876001 tttcgcttct tcaaatgact cactccgata ctggctggca gaaactttta aaatttatta 3876061 tgaacatgag atgcatctga accaggaagc atgccccggt tcattacgca tcacatctat 3876121 cttttcccat aacgtgaaaa aagaccactg acattattca gtggcctaag ctgataatac 3876181 ttttctgcct ttgcggcgac ggcgtgctaa aactagacga ccgttttttg aactcatacg 3876241 gcttctgaag ccatgaactt tgctgcgttt acggttattc ggttggaatg ttcttttcat 3876301 ttatgacacc tccctcgagg aatagctgtt aaagacagtc ttacttatta tatttgcgtt 3876361 acctattcat tgtcaacttc actagtgctt ttatttcttg caaccataat aggataccat 3876421 accttttcaa ctttcgaaac cttatttttt agattcctta attttacgga aaaaagacaa 3876481 attcaaacaa tttgccccta aaatcacgca tgtggatatc tttttcggct ttttttagta 3876541 tccacagagg ttatcgacaa cattttcaca ttaccaaccc ctgtggacaa ggttttttca 3876601 acaggttgtc cgctttgtgg ataagattgt gacaaccatt gcaagctctc gtttattttg 3876661 gtattatatt tgtgttttaa ctcttgatta ctaatcctac ctttcctctt tatccacaaa 3876721 gtgtggataa gttgtggatt gatttcacac agcttgtgta gaaggttgtc cacaagttgt 3876781 gaaatttgtc gaaaagctat ttatctacta tattatatgt tttcaacatt taatgtgtac 3876841 gaatggtaag cgccatttgc tctttttttg tgttctataa cagagaaaga cgccattttc 3876901 taagaaaagg agggacgtgc cggaag //